Neisseria meningitidis antigens and compositions

ABSTRACT

The invention provides proteins from  Neisseria meningitidis , including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.

RELATED APPLICATIONS

This application is a Continuation of U.S. patent application Ser. No.14/450,082, filed Aug. 1, 2014; which is a Continuation of U.S. patentapplication Ser. No. 13/359,442, filed Jan. 26, 2012; which is aContinuation of U.S. patent application Ser. No. 13/070,448, filed Mar.23, 2011; which is Divisional of U.S. patent application Ser. No.12/013,047, filed Jan. 11, 2008, now U.S. Pat. No. 7,988,979; which isContinuation of U.S. patent application Ser. No. 09/674,546, whichclaims an international filing date of Apr. 30, 1999, now U.S. Pat. No.7,576,176; which is the National Stage of International Application No.PCT/US99/09346, filed Apr. 30, 1999; which claims the benefit under 35U.S.C. §119(e) of U.S. Provisional Patent Application Nos. 60/121,528,filed Feb. 25, 1999; 60/103,749, filed Oct. 9, 1998; 60/103,794, filedOct. 9, 1998; 60/103,796, filed Oct. 9, 1998; 60/098,994, filed Sep. 2,1998; 60/099,062, filed Sep. 2, 1998; 60/094,869, filed Jul. 31, 1998and 60/083,758, filed May 1, 1998, the disclosures of which are hereinincorporated by reference in their entirety.

SUBMISSION OF SEQUENCE LISTING ON ASCII TEXT FILE

The content of the following submission on ASCII text file isincorporated herein by reference in its entirety: a computer readableform (CRF) of the Sequence Listing (file name:303822000405SubSeqList.txt, date recorded: Aug. 26, 2015, size: 6317KB).

FIELD OF THE INVENTION

This invention relates to antigens from the bacterial species: Neisseriameningitidis and Neisseria gonorrhoeae.

BACKGROUND

Neisseria meningitidis is a non-motile, gram negative diplococcus humanpathogen. It colonizes the pharynx, causing meningitis and,occasionally, septicaemia in the absence of meningitis. It is closelyrelated to N. gonorrhoea, although one feature that clearlydifferentiates meningococcus from gonococcus is the presence of apolysaccharide capsule that is present in all pathogenic meningococci.

N. meningitidis causes both endemic and epidemic disease. In the UnitedStates the attack rate is 0.6-1 per 100,000 persons per year, and it canbe much greater during outbreaks. (see Lieberman et al. (1996) Safetyand Immunogenicity of a Serogroups A/C Neisseria meningitidisOligosaccharide-Protein Conjugate Vaccine in Young Children. JAMA275(19):1499-1503; Schuchat et al (1997) Bacterial Meningitis in theUnited States in 1995. N Engl J Med 337(14):970-976). In developingcountries, endemic disease rates are much higher and during epidemicsincidence rates can reach 500 cases per 100,000 persons per year.Mortality is extremely high, at 10-20% in the United States, and muchhigher in developing countries. Following the introduction of theconjugate vaccine against Haemophilus influenzae, N. meningitidis is themajor cause of bacterial meningitis at all ages in the United States(Schuchat et al (1997) supra).

Based on the organism's capsular polysaccharide, 12 serogroups of N.meningitidis have been identified. Group A is the pathogen most oftenimplicated in epidemic disease in sub-Saharan Africa. Serogroups B and Care responsible for the vast majority of cases in the United States andin most developed countries. Serogroups W135 and Y are responsible forthe rest of the cases in the United States and developed countries. Themeningococcal vaccine currently in use is a tetravalent polysaccharidevaccine composed of serogroups A, C, Y and W135. Although efficacious inadolescents and adults, it induces a poor immune response and shortduration of protection, and cannot be used in infants [eg. Morbidity andMortality weekly report, Vol. 46, No. RR-5 (1997)]. This is becausepolysaccharides are T-cell independent antigens that induce a weakimmune response that cannot be boosted by repeated immunization.Following the success of the vaccination against H.influenzae, conjugatevaccines against serogroups A and C have been developed and are at thefinal stage of clinical testing (Zollinger W D “New and ImprovedVaccines Against Meningococcal Disease”. In: New Generation Vaccines,supra, pp. 469-488; Lieberman et al (1996) supra; Costantino et al(1992) Development and phase I clinical testing of a conjugate vaccineagainst meningococcus A and C. Vaccine 10:691-698).

Meningococcus B (menB) remains a problem, however. This serotypecurrently is responsible for approximately 50% of total meningitis inthe United States, Europe, and South America. The polysaccharideapproach cannot be used because the menB capsular polysaccharide is apolymer of α(2-8)-linked N-acetyl neuraminic acid that is also presentin mammalian tissue. This results in tolerance to the antigen; indeed,if an immune response were elicited, it would be anti-self, andtherefore undesirable. In order to avoid induction of autoimmunity andto induce a protective immune response, the capsular polysaccharide has,for instance, been chemically modified substituting the N-acetyl groupswith N-propionyl groups, leaving the specific antigenicity unaltered(Romero & Outschoorn (1994) Current status of Meningococcal group Bvaccine candidates: capsular or non-capsular? Clin Microbiol Rev7(4):559-575).

Alternative approaches to menB vaccines have used complex mixtures ofouter membrane proteins (OMPs), containing either the OMPs alone, orOMPs enriched in porins, or deleted of the class 4 OMPs that arebelieved to induce antibodies that block bactericidal activity. Thisapproach produces vaccines that are not well characterized. They areable to protect against the homologous strain, but are not effective atlarge where there are many antigenic variants of the outer membraneproteins. To overcome the antigenic variability, multivalent vaccinescontaining up to nine different porins have been constructed (eg.Poolman J T (1992) Development of a meningococcal vaccine. Infect.Agents Dis. 4:13-28). Additional proteins to be used in outer membranevaccines have been the opa and opc proteins, but none of theseapproaches have been able to overcome the antigenic variability (eg.Ala′ Aldeen & Borriello (1996) The meningococcal transferrin-bindingproteins 1 and 2 are both surface exposed and generate bactericidalantibodies capable of killing homologous and heterologous strains.Vaccine 14(1):49-53).

A certain amount of sequence data is available for meningococcal andgonoccocal genes and proteins (eg. EP-A-0467714, WO96/29412), but thisis by no means complete. The provision of further sequences couldprovide an opportunity to identify secreted or surface-exposed proteinsthat are presumed targets for the immune system and which are notantigenically variable. For instance, some of the identified proteinscould be components of efficacious vaccines against meningococcus B,some could be components of vaccines against all meningococcalserotypes, and others could be components of vaccines against allpathogenic Neisseriae including Neisseria meningitidis or Neisseriagonorrhoeae. Those sequences specific to N. meningitidis or N.gonorrhoeae that are more highly conserved are further preferredsequences.

It is thus an object of the invention is to provide Neisserial DNAsequences which encode proteins that are antigenic or immunogenic.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1A through FIG. 1E illustrate the products of (FIG. 1B) proteinexpression and (FIG. 1A) purification, (FIG. 1C) FACs analysis, (FIG.1D) bactericidal assay, and (FIG. 1E) western blot. The result of theELISA assay of the predicted ORF 919 as cloned and expressed in E. coliwas positive.

FIG. 2A through FIG. 2D illustrate the products of (FIG. 2A) proteinexpression and purification, (FIG. 2B) western blot, (FIG. 2C) FACsanalysis, and (FIG. 2D) bactericidal assay. The result of the ELISAassay of the predicted ORF 279 as cloned and expressed in E. coli waspositive.

FIG. 3A through FIG. 3D illustrate the products of (FIG. 3A) proteinexpression and purification, (FIG. 3B) western blot, (FIG. 3C) FACsanalysis, and (FIG. 3D) bactericidal assay. The result of the ELISAassay of the predicted ORF 576-1 as cloned and expressed in E. coli waspositive.

FIG. 4A through FIG. 4D illustrate the products of (FIG. 4A) proteinexpression and purification, (FIG. 4B) western blot, (FIG. 4C) FACsanalysis, and (FIG. 4D) bactericidal assay. The result of the ELISAassay of the predicted ORF 519-1 as cloned and expressed in E. coli waspositive.

FIG. 5A through FIG. 5D illustrate the products of (FIG. 5A) proteinexpression and purification, (FIG. 5B) western blot, (FIG. 5C) FACsanalysis, and (FIG. 5D) bactericidal assay. The result of the ELISAassay of the predicted ORF 121-1 as cloned and expressed in E. coli waspositive.

FIG. 6A through FIG. 6D illustrate the products of (FIG. 6A) proteinexpression and purification, (FIG. 6B) western blot, (FIG. 6C) FACsanalysis, and (FIG. 6D) bactericidal assay. The result of the ELISAassay of the predicted ORF 128-1 as cloned and expressed in E. coli waspositive.

FIG. 7A through FIG. 7D illustrate the products of (FIG. 7A) proteinexpression and purification, (FIG. 7B) western blot, (FIG. 7C) FACsanalysis, and (FIG. 7D) bactericidal assay. The result of the ELISAassay of the predicted ORF 206 as cloned and expressed in E. coli waspositive.

FIG. 8A through FIG. 8C illustrate the products of (FIG. 8A) proteinexpression and purification, (FIG. 8B) FACs analysis, and (FIG. 8C)bactericidal assay. The result of the ELISA assay of the predicted ORF287 as cloned and expressed in E. coli was positive.

FIG. 9A through FIG. 9D illustrate the products of (FIG. 9A) proteinexpression and purification, (FIG. 9B) western blot, (FIG. 9C) FACsanalysis, and (FIG. 9D) bactericidal assay. The result of the ELISAassay of the predicted ORF 406 as cloned and expressed in E. coli waspositive.

FIG. 10 illustrates the hydrophilicity plot, antigenic index and AMPHIregions of the products of protein expression the predicted ORF 919 ascloned and expressed in E. coli.

FIG. 11 illustrates the hydrophilicity plot, antigenic index and AMPHIregions of the products of protein expression the predicted ORF 279 ascloned and expressed in E. coli.

FIG. 12 illustrates the hydrophilicity plot, antigenic index and AMPHIregions of the products of protein expression the predicted ORF 576-1 ascloned and expressed in E. coli.

FIG. 13 illustrates the hydrophilicity plot, antigenic index and AMPHIregions of the products of protein expression the predicted ORF 519-1 ascloned and expressed in E. coli.

FIG. 14 illustrates the hydrophilicity plot, antigenic index and AMPHIregions of the products of protein expression the predicted ORF 121-1 ascloned and expressed in E. coli.

FIG. 15 illustrates the hydrophilicity plot, antigenic index and AMPHIregions of the products of protein expression the predicted ORF 128-1 ascloned and expressed in E. coli.

FIG. 16 illustrates the hydrophilicity plot, antigenic index and AMPHIregions of the products of protein expression the predicted ORF 206 ascloned and expressed in E. coli.

FIG. 17 illustrates the hydrophilicity plot, antigenic index and AMPHIregions of the products of protein expression the predicted ORF 287 ascloned and expressed in E. coli.

FIG. 18 illustrates the hydrophilicity plot, antigenic index and AMPHIregions of the products of protein expression the predicted ORF 406 ascloned and expressed in E. coli.

FIG. 19A, FIG. 19B, and FIG. 19C show an alignment comparison of aminoacid sequences for ORF 225 for several strains of Neisseria. Darkshading indicates regions of homology, and gray shading indicates theconservation of amino acids with similar characteristics. The Figuredemonstrates a high degree of conservation among the various strains,further confirming its utility as an antigen for both vaccines anddiagnostics. The sequences in the Figure have the following SEQ ID NOs:FA1090 SEQ ID 3115; Z2491 SEQ ID 3116; ZO01_(—)225 SEQ ID 3117;ZO02_(—)225 SEQ ID 3118; ZO03_(—)225 SEQ ID 3119; ZO04_(—)225 SEQ ID3120; ZO05225 SEQ ID 3121; ZO06_(—)225 SEQ ID 3122; ZO07_(—)225 SEQ ID3123; ZO08_(—)225 SEQ ID 3124; ZO09_(—)225 SEQ ID 3125; ZO10_(—)225 SEQID 3126; ZO11_(—)225 SEQ ID 3127; ZO12_(—)225 SEQ ID 3128; ZO13_(—)225SEQ ID 3129; ZO14_(—)225 SEQ ID 3130; ZO15_(—)225<SEQ ID 3131;ZO16_(—)225 SEQ ID 3132; ZO17_(—)225 SEQ ID 3133; ZO18_(—)225 SEQ ID3134; ZO19_(—)225 SEQ ID 3135; ZO20_(—)225 SEQ ID 3136; ZO21_(—)225 SEQID 3137; ZO22_(—)225 SEQ ID 3138; ZO23_(—)225 SEQ ID 3139; ZO24_(—)225SEQ ID 3140; ZO25_(—)225 SEQ ID 3141; ZO26_(—)225 SEQ ID 3142;ZO27_(—)225 SEQ ID 3143; ZO28_(—)225 SEQ ID 3144; ZO29_(—)225 SEQ ID3145; ZO32_(—)225 SEQ ID 3146; ZO33_(—)225 SEQ ID 3147; and ZO96_(—)225SEQ ID 3148.

FIG. 20A and FIG. 20B show an alignment comparison of amino acidsequences for ORF 235 for several strains of Neisseria. Dark shadingindicates regions of homology, and gray shading indicates theconservation of amino acids with similar characteristics. The Figuredemonstrates a high degree of conservation among the various strains,further confirming its utility as an antigen for both vaccines anddiagnostics. The sequences in the Figure have the following SEQ ID NOs:FA1090 SEQ ID 3149; GNMZQ01 SEQ ID 3150; GNMZQ02 SEQ ID 3151; GNMZQ03SEQ ID 31521; GNMZQ04 SEQ ID 3153; GNMZQ05 SEQ ID 3154; GNMZQ07 SEQ ID3155; GNMZQ08 SEQ ID 3156; GNMZQ09 SEQ ID 3157; GNMZQ10 SEQ ID 3158;GNMZQ11 SEQ ID 3159; GNMZQ13 SEQ ID 3160; GNMZQ14 SEQ ID 3161; GNMZQ15SEQ ID 3162; GNMZQ16 SEQ ID 3163; GNMZQ17 SEQ ID 3164; GNMZQ18 SEQ ID3165; GNMZQ19 SEQ ID 3166; GNMZQ21 SEQ ID 3166; GNMZQ22 SEQ ID 3167;GNMZQ23 SEQ ID 3168; GNMZQ24 SEQ ID 3169; GNMZQ25 SEQ ID 3170; GNMZQ26SEQ ID 3171; GNMZQ27 SEQ ID 3172; GNMZQ28 SEQ ID 3173; GNMZQ29 SEQ ID3174; GNMZQ31 SEQ ID 3175; GNMZQ32 SEQ ID 3176; GNMZQ33 SEQ ID 3177; andZ2491 SEQ ID 3178.

FIG. 21A and FIG. 21B show an alignment comparison of amino acidsequences for ORF 287 for several strains of Neisseria. Dark shadingindicates regions of homology, and gray shading indicates theconservation of amino acids with similar characteristics. The Figuredemonstrates a high degree of conservation among the various strains,further confirming its utility as an antigen for both vaccines anddiagnostics. The sequences in the Figure have the following SEQ ID NOs:287_(—)14 SEQ ID 3179; 287_(—)2 SEQ ID 3180; 28721 SEQ ID 3181; 287_(—)9SEQ ID 3182; FA1090 SEQ ID 3183; and Z2491 SEQ ID 3184.

FIG. 22A and FIG. 22B show an alignment comparison of amino acidsequences for ORF 519 for several strains of Neisseria. Dark shadingindicates regions of homology, and gray shading indicates theconservation of amino acids with similar characteristics. The Figuredemonstrates a high degree of conservation among the various strains,further confirming its utility as an antigen for both vaccines anddiagnostics. The sequences in the Figure have the following SEQ ID NOs:FA1090_(—)519 SEQ ID 3185; Z2491_(—)519 SEQ ID 3186; ZV01_(—)519 SEQ ID3187; ZV02_(—)519 SEQ ID 3188; ZV03_(—)519 SEQ ID 3189; ZV04_(—)519 SEQID 3190; ZV05_(—)519 SEQ ID 3191; ZV06_(—)519 ASS SEQ ID 3192;ZV07_(—)519 SEQ ID 3193; ZV11_(—)519 SEQ ID 3194; ZV12_(—)519 SEQ ID3195; ZV18_(—)519 SEQ ID 3196; ZV19_(—)519 SEQ ID 3197; ZV20_(—)519 ASSSEQ ID 3198; ZV21_(—)519 ASS SEQ ID 3199; ZV22_(—)519 ASS SEQ ID 3200;ZV26_(—)519 SEQ ID 3201; ZV27_(—)519 SEQ ID 3202; ZV28_(—)519 SEQ ID3203; ZV29_(—)519 ASS SEQ ID 3204; ZV32_(—)519 SEQ ID 3205; andZV96_(—)519 SEQ ID 3206.

FIG. 23A, FIG. 23B, FIG. 23C, and FIG. 23D show an alignment comparisonof amino acid sequences for ORF 919 for several strains of Neisseria.Dark shading indicates regions of homology, and gray shading indicatesthe conservation of amino acids with similar characteristics. The Figuredemonstrates a high degree of conservation among the various strains,further confirming its utility as an antigen for both vaccines anddiagnostics. The sequences in the Figure have the following SEQ ID NOs:FA1090 SEQ ID 3207; Z2491<SEQ ID 3208; ZM01 SEQ ID 3209; ZM02 SEQ ID3210; ZM03 SEQ ID 3211; ZM04 SEQ ID 3212; ZM05 SEQ ID 3213; ZM06 SEQ ID3214; ZM07 SEQ ID 3215; ZM08N SEQ ID 3216; ZM09 SEQ ID 3217; ZM10 SEQ ID3218; ZM11ASBC SEQ ID 3219; ZM12 SEQ ID 3220; ZM13 SEQ ID 3221; ZM14 SEQID 3222; ZM15 SEQ ID 3223; ZM16 SEQ ID 3224; ZM17 SEQ ID 3225; ZM18 SEQID 3226; ZM19 SEQ ID 3227; ZM20 SEQ ID 3228; ZM21 SEQ ID 3229; ZM22 SEQID 3230; ZM23ASBC SEQ ID 3231; ZM24 SEQ ID 3232; ZM25 SEQ ID 3233; ZM26SEQ ID 3234; ZM27BC SEQ ID 3235; ZM28 SEQ ID 3236; ZM29ASBC SEQ ID 3237;ZM31ASBC SEQ ID 3238; ZM32ASBC SEQ ID 3239; ZM33ASBC SEQ ID 3240; ZM96SEQ ID 3241.

THE INVENTION

The invention provides proteins comprising the N. meningitidis aminoacid sequences and N. gonorrhoeae amino acid sequences disclosed in theexamples.

It also provides proteins comprising sequences homologous (i.e., thosehaving sequence identity) to the N. meningitidis amino acid sequencesdisclosed in the examples. Depending on the particular sequence, thedegree of homology (sequence identity) is preferably greater than 50%(eg. 60%, 70%, 80%, 90%, 95%, 99% or more). These proteins includemutants and allelic variants of the sequences disclosed in the examples.Typically, 50% identity or more between two proteins is considered to bean indication of functional equivalence. Identity between proteins ispreferably determined by the Smith-Waterman homology search algorithm asimplemented in MPSRCH program (Oxford Molecular) using an affine gapsearch with parameters:gap penalty 12, gap extension penalty 1.

The invention further provides proteins comprising fragments of the N.meningitidis amino acid sequences and N. gonorrhoeae amino acidsequences disclosed in the examples. The fragments should comprise atleast n consecutive amino acids from the sequences and, depending on theparticular sequence, n is 7 or more (eg. 8, 10, 12, 14, 16, 18, 20 ormore). Preferably the fragments comprise an epitope from the sequence.

The proteins of the invention can, of course, be prepared by variousmeans (eg. recombinant expression, purification from cell culture,chemical synthesis etc.) and in various forms (eg. native, fusionsetc.). They are preferably prepared in substantially pure or isolatedform (ie. substantially free from other N. meningitidis or N.gonorrhoeae host cell proteins)

According to a further aspect, the invention provides antibodies whichbind to these proteins. These may be polyclonal or monoclonal and may beproduced by any suitable means.

According to a further aspect, the invention provides nucleic acidcomprising the N. meningitidis nucleotide sequences and N. gonorrhoeaenucleotide sequences disclosed in the examples.

According to a further aspect, the invention comprises nucleic acidshaving sequence identity of greater than 50% (e.g., 60%, 70%, 80%, 90%,95%, 99% or more) to the nucleic acid sequences herein. Sequenceidentity is determined as above-discussed.

According to a further aspect, the invention comprises nucleic acid thathybridizes to the sequences provided herein. Conditions forhybridization are set forth herein.

Nucleic acid comprising fragments of these sequences are also provided.These should comprise at least n consecutive nucleotides from the N.meningitidis sequences or N. gonorrhoeae sequences and depending on theparticular sequence, n is 10 or more (eg 12, 14, 15, 18, 20, 25, 30, 35,40 or more).

According to a further aspect, the invention provides nucleic acidencoding the proteins and protein fragments of the invention.

It should also be appreciated that the invention provides nucleic acidcomprising sequences complementary to those described above (eg. forantisense or probing purposes).

Nucleic acid according to the invention can, of course, be prepared inmany ways (eg. by chemical synthesis, in part or in whole, from genomicor cDNA libraries, from the organism itself etc.) and can take variousforms (eg. single stranded, double stranded, vectors, probes etc.).

In addition, the term “nucleic acid” includes DNA and RNA, and alsotheir analogues, such as those containing modified backbones, and alsoprotein nucleic acids (PNA) etc.

According to a further aspect, the invention provides vectors comprisingnucleotide sequences of the invention (eg. expression vectors) and hostcells transformed with such vectors.

According to a further aspect, the invention provides compositionscomprising protein, antibody, and/or nucleic acid according to theinvention. These compositions may be suitable as vaccines, for instance,or as diagnostic reagents or as immunogenic compositions.

The invention also provides nucleic acid, protein, or antibody accordingto the invention for use as medicaments (eg. as vaccines) or asdiagnostic reagents. It also provides the use of nucleic acid, protein,or antibody according to the invention in the manufacture of (I) amedicament for treating or preventing infection due to Neisserialbacteria (ii) a diagnostic reagent for detecting the presence of Neisserial bacteria or of antibodies raised against Neis serial bacteria or(iii) for raising antibodies. Said Neisserial bacteria may be anyspecies or strain (such as N. gonorrhoeae) but are preferably N.meningitidis, especially strain B or strain C.

The invention also provides a method of treating a patient, comprisingadministering to the patient a therapeutically effective amount ofnucleic acid, protein, and/or antibody according to the invention.

According to further aspects, the invention provides various processes.

A process for producing proteins of the invention is provided,comprising the step of culturing a host cell according to the inventionunder conditions which induce protein expression.

A process for detecting polynucleotides of the invention is provided,comprising the steps of: (a) contacting a nucleic probe according to theinvention with a biological sample under hybridizing conditions to formduplexes; and (b) detecting said duplexes.

A process for detecting proteins of the invention is provided,comprising the steps of: (a) contacting an antibody according to theinvention with a biological sample under conditions suitable for theformation of an antibody-antigen complexes; and (b) detecting saidcomplexes.

A summary of standard techniques and procedures which may be employed inorder to perform the invention (eg. to utilize the disclosed sequencesfor vaccination or diagnostic purposes) is attached as an Appendix tothe application. This summary is not a limitation on the invention but,rather, gives examples that may be used, but are not required.

Having now generally described the invention, the same will be morereadily understood through reference to the following examples which areprovided by way of illustration, and are not intended to be limiting ofthe present invention, unless specified.

Methodology—Summary of Standard Procedures and Techniques.

General This invention provides Neisseria meningitidis menB nucleotidesequences, amino acid sequences encoded therein. With these disclosedsequences, nucleic acid probe assays and expression cassettes andvectors can be produced. The expression vectors can be transformed intohost cells to produce proteins. The purified or isolated polypeptides(which may also be chemically synthesized) can be used to produceantibodies to detect menB proteins. Also, the host cells or extracts canbe utilized for biological assays to isolate agonists or antagonists. Inaddition, with these sequences one can search to identify open readingframes and identify amino acid sequences. The proteins may also be usedin immunogenic compositions, antigenic compositions and as vaccinecomponents.

The practice of the present invention will employ, unless otherwiseindicated, conventional techniques of molecular biology, microbiology,recombinant DNA, and immunology, which are within the skill of the art.Such techniques are explained fully in the literature e.g., SambrookMolecular Cloning; A Laboratory Manual, Second Edition (1989); DNACloning, Volumes I and ii (D. N Glover ed. 1985); OligonucleotideSynthesis (M. J. Gait ed, 1984); Nucleic Acid Hybridization (B. D. Hames& S. J. Higgins eds. 1984); Transcription and Translation (B. D. Hames &S. J. Higgins eds. 1984); Animal Cell Culture (R. I. Freshney ed. 1986);Immobilized Cells and Enzymes (IRL Press, 1986); B. Perbal, A PracticalGuide to Molecular Cloning (1984); the Methods in Enzymology series(Academic Press, Inc.), especially volumes 154 & 155; Gene TransferVectors for Mammalian Cells (J. H. Miller and M. P. Calos eds. 1987,Cold Spring Harbor Laboratory); Mayer and Walker, eds. (1987),Immunochemical Methods in Cell and Molecular Biology (Academic Press,London); Scopes, (1987) Protein Purification: Principles and Practice,Second Edition (Springer-Verlag, N.Y.), and Handbook of ExperimentalImmunology, Volumes I-IV (D. M. Weir and C. C. Blackwell eds 1986).

Standard abbreviations for nucleotides and amino acids are used in thisspecification.

All publications, patents, and patent applications cited herein areincorporated in full by reference.

Expression Systems

The Neisseria menB nucleotide sequences can be expressed in a variety ofdifferent expression systems; for example those used with mammaliancells, plant cells, baculoviruses, bacteria, and yeast.

i. Mammalian Systems

Mammalian expression systems are known in the art. A mammalian promoteris any DNA sequence capable of binding mammalian RNA polymerase andinitiating the downstream (3′) transcription of a coding sequence (e.g.,structural gene) into mRNA. A promoter will have a transcriptioninitiating region, which is usually placed proximal to the 5′ end of thecoding sequence, and a TATA box, usually located 25-30 base pairs (bp)upstream of the transcription initiation site. The TATA box is thoughtto direct RNA polymerase II to begin RNA synthesis at the correct site.A mammalian promoter will also contain an upstream promoter element,usually located within 100 to 200 bp upstream of the TATA box. Anupstream promoter element determines the rate at which transcription isinitiated and can act in either orientation (Sambrook et al. (1989)“Expression of Cloned Genes in Mammalian Cells.” In Molecular Cloning: ALaboratory Manual, 2nd ed.).

Mammalian viral genes are often highly expressed and have a broad hostrange; therefore sequences encoding mammalian viral genes provideparticularly useful promoter sequences. Examples include the SV40 earlypromoter, mouse mammary tumor virus LTR promoter, adenovirus major latepromoter (Ad MLP), and herpes simplex virus promoter. In addition,sequences derived from non-viral genes, such as the murinemetallothionein gene, also provide useful promoter sequences. Expressionmay be either constitutive or regulated (inducible). Depending on thepromoter selected, many promotes may be inducible using knownsubstrates, such as the use of the mouse mammary tumor virus (MMTV)promoter with the glucocorticoid responsive element (GRE) that isinduced by glucocorticoid in hormone-responsive transformed cells (seefor example, U.S. Pat. No. 5,783,681).

The presence of an enhancer element (enhancer), combined with thepromoter elements described above, will usually increase expressionlevels. An enhancer is a regulatory DNA sequence that can stimulatetranscription up to 1000-fold when linked to homologous or heterologouspromoters, with synthesis beginning at the normal RNA start site.Enhancers are also active when they are placed upstream or downstreamfrom the transcription initiation site, in either normal or flippedorientation, or at a distance of more than 1000 nucleotides from thepromoter (Maniatis et al. (1987) Science 236:1237; Alberts et al. (1989)Molecular Biology of the Cell, 2nd ed.). Enhancer elements derived fromviruses may be particularly useful, because they usually have a broaderhost range. Examples include the SV40 early gene enhancer (Dijkema et al(1985) EMBO J. 4:761) and the enhancer/promoters derived from the longterminal repeat (LTR) of the Rous Sarcoma Virus (Gorman et al. (1982b)Proc. Natl. Acad. Sci. 79:6777) and from human cytomegalovirus (Boshartet al. (1985) Cell 41:521). Additionally, some enhancers are regulatableand become active only in the presence of an inducer, such as a hormoneor metal ion (Sassone-Corsi and Borelli (1986) Trends Genet. 2:215;Maniatis et al. (1987) Science 236:1237).

A DNA molecule may be expressed intracellularly in mammalian cells. Apromoter sequence may be directly linked with the DNA molecule, in whichcase the first amino acid at the N-terminus of the recombinant proteinwill always be a methionine, which is encoded by the ATG start codon. Ifdesired, the N-terminus may be cleaved from the protein by in vitroincubation with cyanogen bromide.

Alternatively, foreign proteins can also be secreted from the cell intothe growth media by creating chimeric DNA molecules that encode a fusionprotein comprised of a leader sequence fragment that provides forsecretion of the foreign protein in mammalian cells. Preferably, thereare processing sites encoded between the leader fragment and the foreigngene that can be cleaved either in vivo or in vitro. The leader sequencefragment usually encodes a signal peptide comprised of hydrophobic aminoacids which direct the secretion of the protein from the cell. Theadenovirus tripartite leader is an example of a leader sequence thatprovides for secretion of a foreign protein in mammalian cells.

Usually, transcription termination and polyadenylation sequencesrecognized by mammalian cells are regulatory regions located 3′ to thetranslation stop codon and thus, together with the promoter elements,flank the coding sequence. The 3′ terminus of the mature mRNA is formedby site-specific post-transcriptional cleavage and polyadenylation(Birnstiel et al. (1985) Cell 41:349; Proudfoot and Whitelaw (1988)“Termination and 3′ end processing of eukaryotic RNA. In Transcriptionand splicing (ed. B. D. Hames and D. M. Glover); Proudfoot (1989) TrendsBiochem. Sci. 14:105). These sequences direct the transcription of anmRNA which can be translated into the polypeptide encoded by the DNA.Examples of transcription terminator/polyadenylation signals includethose derived from SV40 (Sambrook et al (1989) “Expression of clonedgenes in cultured mammalian cells.” In Molecular Cloning: A LaboratoryManual).

Usually, the above described components, comprising a promoter,polyadenylation signal, and transcription termination sequence are puttogether into expression constructs. Enhancers, introns with functionalsplice donor and acceptor sites, and leader sequences may also beincluded in an expression construct, if desired. Expression constructsare often maintained in a replicon, such as an extrachromosomal element(e.g., plasmids) capable of stable maintenance in a host, such asmammalian cells or bacteria. Mammalian replication systems include thosederived from animal viruses, which require trans-acting factors toreplicate. For example, plasmids containing the replication systems ofpapovaviruses, such as SV40 (Gluzman (1981) Cell 23:175) orpolyomavirus, replicate to extremely high copy number in the presence ofthe appropriate viral T antigen. Additional examples of mammalianreplicons include those derived from bovine papillomavirus andEpstein-Barr virus. Additionally, the replicon may have two replicationsystems, thus allowing it to be maintained, for example, in mammaliancells for expression and in a prokaryotic host for cloning andamplification. Examples of such mammalian-bacteria shuttle vectorsinclude pMT2 (Kaufman et al. (1989) Mol. Cell. Biol. 9:946) and pHEBO(Shimizu et al. (1986) Mol. Cell. Biol. 6:1074).

The transformation procedure used depends upon the host to betransformed. Methods for introduction of heterologous polynucleotidesinto mammalian cells are known in the art and include dextran-mediatedtransfection, calcium phosphate precipitation, polybrene mediatedtransfection, protoplast fusion, electroporation, encapsulation of thepolynucleotide(s) in liposomes, and direct microinjection of the DNAinto nuclei.

Mammalian cell lines available as hosts for expression are known in theart and include many immortalized cell lines available from the AmericanType Culture Collection (ATCC), including but not limited to, Chinesehamster ovary (CHO) cells, HeLa cells, baby hamster kidney (BHK) cells,monkey kidney cells (COS), human hepatocellular carcinoma cells (e.g.,Hep G2), and a number of other cell lines.

ii. Plant Cellular Expression Systems

There are many plant cell culture and whole plant genetic expressionsystems known in the art. Exemplary plant cellular genetic expressionsystems include those described in patents, such as: U.S. Pat. No.5,693,506; U.S. Pat. No. 5,659,122; and U.S. Pat. No. 5,608,143.Additional examples of genetic expression in plant cell culture has beendescribed by Zenk, Phytochemistry 30:3861-3863 (1991). Descriptions ofplant protein signal peptides may be found in addition to the referencesdescribed above in Vaulcombe et al., Mol. Gen. Genet. 209:33-40 (1987);Chandler et al., Plant Molecular Biology 3:407-418 (1984); Rogers, J.Biol. Chem. 260:3731-3738 (1985); Rothstein et al., Gene 55:353-356(1987); Whittier et al., Nucleic Acids Research 15:2515-2535 (1987);Wirsel et al., Molecular Microbiology 3:3-14 (1989); Yu et al., Gene122:247-253 (1992). A description of the regulation of plant geneexpression by the phytohormone, gibberellic acid and secreted enzymesinduced by gibberellic acid can be found in R. L. Jones and J.MacMillin, Gibberellins: in: Advanced Plant Physiology, Malcolm B.Wilkins, ed., 1984 Pitman Publishing Limited, London, pp. 21-52.References that describe other metabolically-regulated genes: Sheen,Plant Cell, 2:1027-1038 (1990); Maas et al., EMBO J. 9:3447-3452 (1990);Benkel and Hickey, Proc. Natl. Acad. Sci. 84:1337-1339 (1987)

Typically, using techniques known in the art, a desired polynucleotidesequence is inserted into an expression cassette comprising geneticregulatory elements designed for operation in plants. The expressioncassette is inserted into a desired expression vector with companionsequences upstream and downstream from the expression cassette suitablefor expression in a plant host. The companion sequences will be ofplasmid or viral origin and provide necessary characteristics to thevector to permit the vectors to move DNA from an original cloning host,such as bacteria, to the desired plant host. The basic bacterial/plantvector construct will preferably provide a broad host range prokaryotereplication origin; a prokaryote selectable marker; and, forAgrobacterium transformations, T DNA sequences forAgrobacterium-mediated transfer to plant chromosomes. Where theheterologous gene is not readily amenable to detection, the constructwill preferably also have a selectable marker gene suitable fordetermining if a plant cell has been transformed. A general review ofsuitable markers, for example for the members of the grass family, isfound in Wilmink and Dons, 1993, Plant Mol. Biol. Reptr, 11(2):165-185.

Sequences suitable for permitting integration of the heterologoussequence into the plant genome are also recommended. These might includetransposon sequences and the like for homologous recombination as wellas Ti sequences which permit random insertion of a heterologousexpression cassette into a plant genome. Suitable prokaryote selectablemarkers include resistance toward antibiotics such as ampicillin ortetracycline. Other DNA sequences encoding additional functions may alsobe present in the vector, as is known in the art.

The nucleic acid molecules of the subject invention may be included intoan expression cassette for expression of the protein(s) of interest.Usually, there will be only one expression cassette, although two ormore are feasible. The recombinant expression cassette will contain inaddition to the heterologous protein encoding sequence the followingelements, a promoter region, plant 5′ untranslated sequences, initiationcodon depending upon whether or not the structural gene comes equippedwith one, and a transcription and translation termination sequence.Unique restriction enzyme sites at the 5′ and 3′ ends of the cassetteallow for easy insertion into a pre-existing vector.

A heterologous coding sequence may be for any protein relating to thepresent invention. The sequence encoding the protein of interest willencode a signal peptide which allows processing and translocation of theprotein, as appropriate, and will usually lack any sequence which mightresult in the binding of the desired protein of the invention to amembrane. Since, for the most part, the transcriptional initiationregion will be for a gene which is expressed and translocated duringgermination, by employing the signal peptide which provides fortranslocation, one may also provide for translocation of the protein ofinterest. In this way, the protein(s) of interest will be translocatedfrom the cells in which they are expressed and may be efficientlyharvested. Typically secretion in seeds are across the aleurone orscutellar epithelium layer into the endosperm of the seed. While it isnot required that the protein be secreted from the cells in which theprotein is produced, this facilitates the isolation and purification ofthe recombinant protein.

Since the ultimate expression of the desired gene product will be in aeucaryotic cell it is desirable to determine whether any portion of thecloned gene contains sequences which will be processed out as introns bythe host's splicosome machinery. If so, site-directed mutagenesis of the“intron” region may be conducted to prevent losing a portion of thegenetic message as a false intron code, Reed and Maniatis, Cell41:95-105, 1985.

The vector can be microinjected directly into plant cells by use ofmicropipettes to mechanically transfer the recombinant DNA. Crossway,Mol. Gen. Genet, 202:179-185, 1985. The genetic material may also betransferred into the plant cell by using polyethylene glycol, Krens, etal., Nature, 296, 72-74, 1982. Another method of introduction of nucleicacid segments is high velocity ballistic penetration by small particleswith the nucleic acid either within the matrix of small beads orparticles, or on the surface, Klein, et al., Nature, 327, 70-73, 1987and Knudsen and Muller, 1991, Planta, 185:330-336 teaching particlebombardment of barley endosperm to create transgenic barley. Yet anothermethod of introduction would be fusion of protoplasts with otherentities, either minicells, cells, lysosomes or other fusiblelipid-surfaced bodies, Fraley, et al., Proc. Natl. Acad. Sci. USA, 79,1859-1863, 1982.

The vector may also be introduced into the plant cells byelectroporation. (Fromm et al., Proc. Natl Acad. Sci. USA 82:5824,1985). In this technique, plant protoplasts are electroporated in thepresence of plasmids containing the gene construct. Electrical impulsesof high field strength reversibly permeabilize biomembranes allowing theintroduction of the plasmids. Electroporated plant protoplasts reformthe cell wall, divide, and form plant callus.

All plants from which protoplasts can be isolated and cultured to givewhole regenerated plants can be transformed by the present invention sothat whole plants are recovered which contain the transferred gene. Itis known that practically all plants can be regenerated from culturedcells or tissues, including but not limited to all major species ofsugarcane, sugar beet, cotton, fruit and other trees, legumes andvegetables. Some suitable plants include, for example, species from thegenera Fragaria, Lotus, Medicago, Onobrychis, Trifolium, Trigonella,Vigna, Citrus, Linum, Geranium, Manihot, Daucus, Arabidopsis, Brassica,Raphanus, Sinapis, Atropa, Capsicum, Datura, Hyoscyamus, Lycopersion,Nicotiana, Solanum, Petunia, Digitalis, Majorana, Cichorium, Helianthus,Lactuca, Bromus, Asparagus, Antirrhinum, Hererocallis, Nemesia,Pelargonium, Panicum, Pennisetum, Ranunculus, Senecio, Salpiglossis,Cucumis, Browaalia, Glycine, Lolium, Zea, Triticum, Sorghum, and Datura.

Means for regeneration vary from species to species of plants, butgenerally a suspension of transformed protoplasts containing copies ofthe heterologous gene is first provided. Callus tissue is formed andshoots may be induced from callus and subsequently rooted.Alternatively, embryo formation can be induced from the protoplastsuspension. These embryos germinate as natural embryos to form plants.The culture media will generally contain various amino acids andhormones, such as auxin and cytokinins. It is also advantageous to addglutamic acid and proline to the medium, especially for such species ascorn and alfalfa. Shoots and roots normally develop simultaneously.Efficient regeneration will depend on the medium, on the genotype, andon the history of the culture. If these three variables are controlled,then regeneration is fully reproducible and repeatable.

In some plant cell culture systems, the desired protein of the inventionmay be excreted or alternatively, the protein may be extracted from thewhole plant. Where the desired protein of the invention is secreted intothe medium, it may be collected. Alternatively, the embryos andembryoless-half seeds or other plant tissue may be mechanicallydisrupted to release any secreted protein between cells and tissues. Themixture may be suspended in a buffer solution to retrieve solubleproteins. Conventional protein isolation and purification methods willbe then used to purify the recombinant protein. Parameters of time,temperature pH, oxygen, and volumes will be adjusted through routinemethods to optimize expression and recovery of heterologous protein.

iii. Baculovirus Systems

The polynucleotide encoding the protein can also be inserted into asuitable insect expression vector, and is operably linked to the controlelements within that vector. Vector construction employs techniqueswhich are known in the art. Generally, the components of the expressionsystem include a transfer vector, usually a bacterial plasmid, whichcontains both a fragment of the baculovirus genome, and a convenientrestriction site for insertion of the heterologous gene or genes to beexpressed; a wild type baculovirus with a sequence homologous to thebaculovirus-specific fragment in the transfer vector (this allows forthe homologous recombination of the heterologous gene in to thebaculovirus genome); and appropriate insect host cells and growth media.

After inserting the DNA sequence encoding the protein into the transfervector, the vector and the wild type viral genome are transfected intoan insect host cell where the vector and viral genome are allowed torecombine. The packaged recombinant virus is expressed and recombinantplaques are identified and purified. Materials and methods forbaculovirus/insect cell expression systems are commercially available inkit form from, inter alia, Invitrogen, San Diego Calif. (“MAXBAC™” kit).These techniques are generally known to those skilled in the art andfully described in Summers and Smith, Texas Agricultural ExperimentStation Bulletin No. 1555 (1987) (hereinafter “Summers and Smith”).

Prior to inserting the DNA sequence encoding the protein into thebaculovirus genome, the above described components, comprising apromoter, leader (if desired), coding sequence of interest, andtranscription termination sequence, are usually assembled into anintermediate transplacement construct (transfer vector). This constructmay contain a single gene and operably linked regulatory elements;multiple genes, each with its owned set of operably linked regulatoryelements; or multiple genes, regulated by the same set of regulatoryelements. Intermediate transplacement constructs are often maintained ina replicon, such as an extrachromosomal element (e.g., plasmids) capableof stable maintenance in a host, such as a bacterium. The replicon willhave a replication system, thus allowing it to be maintained in asuitable host for cloning and amplification.

Currently, the most commonly used transfer vector for introducingforeign genes into AcNPV is pAc373. Many other vectors, known to thoseof skill in the art, have also been designed. These include, forexample, pVL985 (which alters the polyhedrin start codon from ATG toATT, and which introduces a BamHI cloning site 32 basepairs downstreamfrom the ATT; see Luckow and Summers, Virology (1989) 17:31.

The plasmid usually also contains the polyhedrin polyadenylation signal(Miller et al. (1988) Ann. Rev. Microbiol., 42:177) and a prokaryoticampicillin-resistance (amp) gene and origin of replication for selectionand propagation in E. coli.

Baculovirus transfer vectors usually contain a baculovirus promoter. Abaculovirus promoter is any DNA sequence capable of binding abaculovirus RNA polymerase and initiating the downstream (5′ to 3′)transcription of a coding sequence (e.g., structural gene) into mRNA. Apromoter will have a transcription initiation region which is usuallyplaced proximal to the 5′ end of the coding sequence. This transcriptioninitiation region usually includes an RNA polymerase binding site and atranscription initiation site. A baculovirus transfer vector may alsohave a second domain called an enhancer, which, if present, is usuallydistal to the structural gene. Expression may be either regulated orconstitutive.

Structural genes, abundantly transcribed at late times in a viralinfection cycle, provide particularly useful promoter sequences.Examples include sequences derived from the gene encoding the viralpolyhedron protein, Friesen et al., (1986) “The Regulation ofBaculovirus Gene Expression,” in: The Molecular Biology of Baculoviruses(ed. Walter Doerfler); EPO Publ. Nos. 127 839 and 155 476; and the geneencoding the p10 protein, Vlak et al., (1988), J. Gen. Virol. 69:765.

DNA encoding suitable signal sequences can be derived from genes forsecreted insect or baculovirus proteins, such as the baculoviruspolyhedrin gene (Carbonell et al. (1988) Gene, 73:409). Alternatively,since the signals for mammalian cell posttranslational modifications(such as signal peptide cleavage, proteolytic cleavage, andphosphorylation) appear to be recognized by insect cells, and thesignals required for secretion and nuclear accumulation also appear tobe conserved between the invertebrate cells and vertebrate cells,leaders of non-insect origin, such as those derived from genes encodinghuman (alpha) α-interferon, Maeda et al., (1985), Nature 315:592; humangastrin-releasing peptide, Lebacq-Verheyden et al., (1988), Molec. Cell.Biol. 8:3129; human IL-2, Smith et al., (1985) Proc. Nat'l Acad. Sci.USA, 82:8404; mouse IL-3, (Miyajima et al., (1987) Gene 58:273; andhuman glucocerebrosidase, Martin et al. (1988) DNA, 7:99, can also beused to provide for secretion in insects.

A recombinant polypeptide or polyprotein may be expressedintracellularly or, if it is expressed with the proper regulatorysequences, it can be secreted. Good intracellular expression of nonfusedforeign proteins usually requires heterologous genes that ideally have ashort leader sequence containing suitable translation initiation signalspreceding an ATG start signal. If desired, methionine at the N-terminusmay be cleaved from the mature protein by in vitro incubation withcyanogen bromide.

Alternatively, recombinant polyproteins or proteins which are notnaturally secreted can be secreted from the insect cell by creatingchimeric DNA molecules that encode a fusion protein comprised of aleader sequence fragment that provides for secretion of the foreignprotein in insects. The leader sequence fragment usually encodes asignal peptide comprised of hydrophobic amino acids which direct thetranslocation of the protein into the endoplasmic reticulum.

After insertion of the DNA sequence and/or the gene encoding theexpression product precursor of the protein, an insect cell host isco-transformed with the heterologous DNA of the transfer vector and thegenomic DNA of wild type baculovirus—usually by co-transfection. Thepromoter and transcription termination sequence of the construct willusually comprise a 2-5 kb section of the baculovirus genome. Methods forintroducing heterologous DNA into the desired site in the baculovirusvirus are known in the art. (See Summers and Smith supra; Ju et al.(1987); Smith et al., Mol. Cell. Biol. (1983) 3:2156; and Luckow andSummers (1989)). For example, the insertion can be into a gene such asthe polyhedrin gene, by homologous double crossover recombination;insertion can also be into a restriction enzyme site engineered into thedesired baculovirus gene. Miller et al., (1989), Bioessays 4:91. The DNAsequence, when cloned in place of the polyhedrin gene in the expressionvector, is flanked both 5′ and 3′ by polyhedrin-specific sequences andis positioned downstream of the polyhedrin promoter.

The newly formed baculovirus expression vector is subsequently packagedinto an infectious recombinant baculovirus. Homologous recombinationoccurs at low frequency (between about 1% and about 5%); thus, themajority of the virus produced after cotransfection is still wild-typevirus. Therefore, a method is necessary to identify recombinant viruses.An advantage of the expression system is a visual screen allowingrecombinant viruses to be distinguished. The polyhedrin protein, whichis produced by the native virus, is produced at very high levels in thenuclei of infected cells at late times after viral infection.Accumulated polyhedrin protein forms occlusion bodies that also containembedded particles. These occlusion bodies, up to 15 μm in size, arehighly refractile, giving them a bright shiny appearance that is readilyvisualized under the light microscope. Cells infected with recombinantviruses lack occlusion bodies. To distinguish recombinant virus fromwild-type virus, the transfection supernatant is plagued onto amonolayer of insect cells by techniques known to those skilled in theart. Namely, the plaques are screened under the light microscope for thepresence (indicative of wild-type virus) or absence (indicative ofrecombinant virus) of occlusion bodies. Current Protocols inMicrobiology Vol. 2 (Ausubel et al. eds) at 16.8 (Supp. 10, 1990);Summers and Smith, supra; Miller et al. (1989).

Recombinant baculovirus expression vectors have been developed forinfection into several insect cells. For example, recombinantbaculoviruses have been developed for, inter alia: Aedes aegypti,Autographa californica, Bombyx mori, Drosophila melanogaster, Spodopterafrugiperda, and Trichoplusia ni (PCT Pub. No. WO 89/046699; Carbonell etal., (1985) J. Virol. 56:153; Wright (1986) Nature 321:718; Smith etal., (1983) Mol. Cell. Biol. 3:2156; and see generally, Fraser, et al.(1989) In Vitro Cell. Dev. Biol. 25:225).

Cells and cell culture media are commercially available for both directand fusion expression of heterologous polypeptides in abaculovirus/expression system; cell culture technology is generallyknown to those skilled in the art. See, e.g., Summers and Smith supra.

The modified insect cells may then be grown in an appropriate nutrientmedium, which allows for stable maintenance of the plasmid(s) present inthe modified insect host. Where the expression product gene is underinducible control, the host may be grown to high density, and expressioninduced. Alternatively, where expression is constitutive, the productwill be continuously expressed into the medium and the nutrient mediummust be continuously circulated, while removing the product of interestand augmenting depleted nutrients. The product may be purified by suchtechniques as chromatography, e.g., HPLC, affinity chromatography, ionexchange chromatography, etc.; electrophoresis; density gradientcentrifugation; solvent extraction, or the like. As appropriate, theproduct may be further purified, as required, so as to removesubstantially any insect proteins which are also secreted in the mediumor result from lysis of insect cells, so as to provide a product whichis at least substantially free of host debris, e.g., proteins, lipidsand polysaccharides.

In order to obtain protein expression, recombinant host cells derivedfrom the transformants are incubated under conditions which allowexpression of the recombinant protein encoding sequence. Theseconditions will vary, dependent upon the host cell selected. However,the conditions are readily ascertainable to those of ordinary skill inthe art, based upon what is known in the art.

iv. Bacterial Systems

Bacterial expression techniques are known in the art. A bacterialpromoter is any DNA sequence capable of binding bacterial RNA polymeraseand initiating the downstream (3′) transcription of a coding sequence(e.g. structural gene) into mRNA. A promoter will have a transcriptioninitiation region which is usually placed proximal to the 5′ end of thecoding sequence. This transcription initiation region usually includesan RNA polymerase binding site and a transcription initiation site. Abacterial promoter may also have a second domain called an operator,that may overlap an adjacent RNA polymerase binding site at which RNAsynthesis begins. The operator permits negative regulated (inducible)transcription, as a gene repressor protein may bind the operator andthereby inhibit transcription of a specific gene. Constitutiveexpression may occur in the absence of negative regulatory elements,such as the operator. In addition, positive regulation may be achievedby a gene activator protein binding sequence, which, if present isusually proximal (5′) to the RNA polymerase binding sequence. An exampleof a gene activator protein is the catabolite activator protein (CAP),which helps initiate transcription of the lac operon in Escherichia coli(E. coli) (Raibaud et al. (1984) Annu. Rev. Genet. 18:173). Regulatedexpression may therefore be either positive or negative, thereby eitherenhancing or reducing transcription.

Sequences encoding metabolic pathway enzymes provide particularly usefulpromoter sequences. Examples include promoter sequences derived fromsugar metabolizing enzymes, such as galactose, lactose (lac) (Chang etal. (1977) Nature 198:1056), and maltose. Additional examples includepromoter sequences derived from biosynthetic enzymes such as tryptophan(trp) (Goeddel et al. (1980) Nuc. Acids Res. 8:4057; Yelverton et al.(1981) Nucl. Acids Res. 9:731; U.S. Pat. No. 4,738,921; EPO Publ. Nos.036 776 and 121 775). The beta-lactamase (bla) promoter system(Weissmann (1981) “The cloning of interferon and other mistakes.” InInterferon 3 (ed. I. Gresser)), bacteriophage lambda PL (Shimatake etal. (1981) Nature 292:128) and T5 (U.S. Pat. No. 4,689,406) promotersystems also provide useful promoter sequences.

In addition, synthetic promoters which do not occur in nature alsofunction as bacterial promoters. For example, transcription activationsequences of one bacterial or bacteriophage promoter may be joined withthe operon sequences of another bacterial or bacteriophage promoter,creating a synthetic hybrid promoter (U.S. Pat. No. 4,551,433). Forexample, the tac promoter is a hybrid trp-lac promoter comprised of bothtrp promoter and lac operon sequences that is regulated by the lacrepressor (Amann et al. (1983) Gene 25:167; de Boer et al. (1983) Proc.Natl. Acad. Sci. 80:21). Furthermore, a bacterial promoter can includenaturally occurring promoters of non-bacterial origin that have theability to bind bacterial RNA polymerase and initiate transcription. Anaturally occurring promoter of non-bacterial origin can also be coupledwith a compatible RNA polymerase to produce high levels of expression ofsome genes in prokaryotes. The bacteriophage T7 RNA polymerase/promotersystem is an example of a coupled promoter system (Studier et al. (1986)J. Mol. Biol. 189:113; Tabor et al. (1985) Proc Natl. Acad. Sci.82:1074). In addition, a hybrid promoter can also be comprised of abacteriophage promoter and an E. coli operator region (EPO Publ. No. 267851).

In addition to a functioning promoter sequence, an efficient ribosomebinding site is also useful for the expression of foreign genes inprokaryotes. In E. coli, the ribosome binding site is called theShine-Dalgarno (SD) sequence and includes an initiation codon (ATG) anda sequence 3-9 nucleotides in length located 3-11 nucleotides upstreamof the initiation codon (Shine et al. (1975) Nature 254:34). The SDsequence is thought to promote binding of mRNA to the ribosome by thepairing of bases between the SD sequence and the 3′ end of E. coli 16SrRNA (Steitz et al. (1979) “Genetic signals and nucleotide sequences inmessenger RNA.” In Biological Regulation and Development: GeneExpression (ed. R. F. Goldberger)). To express eukaryotic genes andprokaryotic genes with weak ribosome-binding site, it is often necessaryto optimize the distance between the SD sequence and the ATG of theeukaryotic gene (Sambrook et al. (1989) “Expression of cloned genes inEscherichia coli.” In Molecular Cloning: A Laboratory Manual).

A DNA molecule may be expressed intracellularly. A promoter sequence maybe directly linked with the DNA molecule, in which case the first aminoacid at the N-terminus will always be a methionine, which is encoded bythe ATG start codon. If desired, methionine at the N-terminus may becleaved from the protein by in vitro incubation with cyanogen bromide orby either in vivo or in vitro incubation with a bacterial methionineN-terminal peptidase (EPO Publ. No. 219 237).

Fusion proteins provide an alternative to direct expression. Usually, aDNA sequence encoding the N-terminal portion of an endogenous bacterialprotein, or other stable protein, is fused to the 5′ end of heterologouscoding sequences. Upon expression, this construct will provide a fusionof the two amino acid sequences. For example, the bacteriophage lambdacell gene can be linked at the 5′ terminus of a foreign gene andexpressed in bacteria. The resulting fusion protein preferably retains asite for a processing enzyme (factor Xa) to cleave the bacteriophageprotein from the foreign gene (Nagai et al. (1984) Nature 309:810).Fusion proteins can also be made with sequences from the lacZ (Jia etal. (1987) Gene 60:197), trpE (Allen et al. (1987) J. Biotechnol. 5:93;Makoff et al. (1989) J. Gen. Microbiol. 135:11), and Chey (EPO Publ. No.324 647) genes. The DNA sequence at the junction of the two amino acidsequences may or may not encode a cleavable site. Another example is aubiquitin fusion protein. Such a fusion protein is made with theubiquitin region that preferably retains a site for a processing enzyme(e.g. ubiquitin specific processing-protease) to cleave the ubiquitinfrom the foreign protein. Through this method, native foreign proteincan be isolated (Miller et al. (1989) Bio/Technology 7:698).

Alternatively, foreign proteins can also be secreted from the cell bycreating chimeric DNA molecules that encode a fusion protein comprisedof a signal peptide sequence fragment that provides for secretion of theforeign protein in bacteria (U.S. Pat. No. 4,336,336). The signalsequence fragment usually encodes a signal peptide comprised ofhydrophobic amino acids which direct the secretion of the protein fromthe cell. The protein is either secreted into the growth media(gram-positive bacteria) or into the periplasmic space, located betweenthe inner and outer membrane of the cell (gram-negative bacteria).Preferably there are processing sites, which can be cleaved either invivo or in vitro encoded between the signal peptide fragment and theforeign gene.

DNA encoding suitable signal sequences can be derived from genes forsecreted bacterial proteins, such as the E. coli outer membrane proteingene (ompA) (Masui et al. (1983), in: Experimental Manipulation of GeneExpression; Ghrayeb et al. (1984) EMBO J. 3:2437) and the E. colialkaline phosphatase signal sequence (phoA) (Oka et al. (1985) Proc.Natl. Acad. Sci. 82:7212). As an additional example, the signal sequenceof the alpha-amylase gene from various Bacillus strains can be used tosecrete heterologous proteins from B. subtilis (Palva et al. (1982)Proc. Natl. Acad. Sci. USA 79:5582; EPO Publ. No. 244 042).

Usually, transcription termination sequences recognized by bacteria areregulatory regions located 3′ to the translation stop codon, and thustogether with the promoter flank the coding sequence. These sequencesdirect the transcription of an mRNA which can be translated into thepolypeptide encoded by the DNA. Transcription termination sequencesfrequently include DNA sequences of about 50 nucleotides capable offorming stem loop structures that aid in terminating transcription.Examples include transcription termination sequences derived from geneswith strong promoters, such as the trp gene in E. coli as well as otherbiosynthetic genes.

Usually, the above described components, comprising a promoter, signalsequence (if desired), coding sequence of interest, and transcriptiontermination sequence, are put together into expression constructs.Expression constructs are often maintained in a replicon, such as anextrachromosomal element (e.g., plasmids) capable of stable maintenancein a host, such as bacteria. The replicon will have a replicationsystem, thus allowing it to be maintained in a prokaryotic host eitherfor expression or for cloning and amplification. In addition, a repliconmay be either a high or low copy number plasmid. A high copy numberplasmid will generally have a copy number ranging from about 5 to about200, and usually about 10 to about 150. A host containing a high copynumber plasmid will preferably contain at least about 10, and morepreferably at least about 20 plasmids. Either a high or low copy numbervector may be selected, depending upon the effect of the vector and theforeign protein on the host.

Alternatively, the expression constructs can be integrated into thebacterial genome with an integrating vector. Integrating vectors usuallycontain at least one sequence homologous to the bacterial chromosomethat allows the vector to integrate. Integrations appear to result fromrecombinations between homologous DNA in the vector and the bacterialchromosome. For example, integrating vectors constructed with DNA fromvarious Bacillus strains integrate into the Bacillus chromosome (EPOPubl. No. 127 328). Integrating vectors may also be comprised ofbacteriophage or transposon sequences.

Usually, extrachromosomal and integrating expression constructs maycontain selectable markers to allow for the selection of bacterialstrains that have been transformed. Selectable markers can be expressedin the bacterial host and may include genes which render bacteriaresistant to drugs such as ampicillin, chloramphenicol, erythromycin,kanamycin (neomycin), and tetracycline (Davies et al. (1978) Annu. Rev.Microbiol. 32:469). Selectable markers may also include biosyntheticgenes, such as those in the histidine, tryptophan, and leucinebiosynthetic pathways.

Alternatively, some of the above described components can be puttogether in transformation vectors. Transformation vectors are usuallycomprised of a selectable market that is either maintained in a repliconor developed into an integrating vector, as described above.

Expression and transformation vectors, either extra-chromosomalreplicons or integrating vectors, have been developed for transformationinto many bacteria. For example, expression vectors have been developedfor, inter alia, the following bacteria: Bacillus subtilis (Palva et al.(1982) Proc. Natl. Acad. Sci. USA 79:5582; EPO Publ. Nos. 036 259 and063 953; PCT Publ. No. WO 84/04541), Escherichia coli (Shimatake et al.(1981) Nature 292:128; Amann et al. (1985) Gene 40:183; Studier et al.(1986) J. Mol. Biol. 189:113; EPO Publ. Nos. 036 776, 136 829 and 136907), Streptococcus cremoris (Powell et al. (1988) Appl. Environ.Microbiol. 54:655); Streptococcus lividans (Powell et al. (1988) Appl.Environ. Microbiol. 54:655), Streptomyces lividans (U.S. Pat. No.4,745,056).

Methods of introducing exogenous DNA into bacterial hosts are well-knownin the art, and usually include either the transformation of bacteriatreated with CaCl₂ or other agents, such as divalent cations and DMSO.DNA can also be introduced into bacterial cells by electroporation.Transformation procedures usually vary with the bacterial species to betransformed. (See e.g., use of Bacillus: Masson et al. (1989) FEMSMicrobiol. Lett. 60:273; Palva et al. (1982) Proc. Natl. Acad. Sci. USA79:5582; EPO Publ. Nos. 036 259 and 063 953; PCT Publ. No. WO 84/04541;use of Campylobacter: Miller et al. (1988) Proc. Natl. Acad. Sci.85:856; and Wang et al. (1990) J. Bacteriol. 172:949; use of Escherichiacoli: Cohen et al. (1973) Proc. Natl. Acad. Sci. 69:2110; Dower et al.(1988) Nucleic Acids Res. 16:6127; Kushner (1978) “An improved methodfor transformation of Escherichia coli with ColE1-derived plasmids. InGenetic Engineering: Proceedings of the International Symposium onGenetic Engineering (eds. H. W. Boyer and S. Nicosia); Mandel et al.(1970) J. Mol. Biol. 53:159; Taketo (1988) Biochim. Biophys. Acta949:318; use of Lactobacillus: Chassy et al. (1987) FEMS Microbiol.Lett. 44:173; use of Pseudomonas: Fiedler et al. (1988) Anal. Biochem170:38; use of Staphylococcus: Augustin et al. (1990) FEMS Microbiol.Lett. 66:203; use of Streptococcus: Barany et al. (1980) J. Bacteriol.144:698; Harlander (1987) “Transformation of Streptococcus lactis byelectroporation, in: Streptococcal Genetics (ed. J. Ferretti and R.Curtiss III); Perry et al. (1981) Infect. Immun. 32:1295; Powell et al.(1988) Appl. Environ. Microbiol. 54:655; Somkuti et al. (1987) Proc. 4thEvr. Cong. Biotechnology 1:412.

v. Yeast Expression

Yeast expression systems are also known to one of ordinary skill in theart. A yeast promoter is any DNA sequence capable of binding yeast RNApolymerase and initiating the downstream (3′) transcription of a codingsequence (e.g. structural gene) into mRNA. A promoter will have atranscription initiation region which is usually placed proximal to the5′ end of the coding sequence. This transcription initiation regionusually includes an RNA polymerase binding site (the “TATA Box”) and atranscription initiation site. A yeast promoter may also have a seconddomain called an upstream activator sequence (UAS), which, if present,is usually distal to the structural gene. The UAS permits regulated(inducible) expression. Constitutive expression occurs in the absence ofa UAS. Regulated expression may be either positive or negative, therebyeither enhancing or reducing transcription.

Yeast is a fermenting organism with an active metabolic pathway,therefore sequences encoding enzymes in the metabolic pathway provideparticularly useful promoter sequences. Examples include alcoholdehydrogenase (ADH) (EPO Publ. No. 284 044), enolase, glucokinase,glucose-6-phosphate isomerase, glyceraldehyde-3-phosphate-dehydrogenase(GAP or GAPDH), hexokinase, phosphofructokinase, 3-phosphoglyceratemutase, and pyruvate kinase (PyK) (EPO Publ. No. 329 203). The yeastPHO5 gene, encoding acid phosphatase, also provides useful promotersequences (Myanohara et al. (1983) Proc. Natl. Acad. Sci. USA 80:1).

In addition, synthetic promoters which do not occur in nature alsofunction as yeast promoters. For example, UAS sequences of one yeastpromoter may be joined with the transcription activation region ofanother yeast promoter, creating a synthetic hybrid promoter. Examplesof such hybrid promoters include the ADH regulatory sequence linked tothe GAP transcription activation region (U.S. Pat. Nos. 4,876,197 and4,880,734). Other examples of hybrid promoters include promoters whichconsist of the regulatory sequences of either the ADH2, GAL4, GAL10, ORPHO5 genes, combined with the transcriptional activation region of aglycolytic enzyme gene such as GAP or PyK (EPO Publ. No. 164 556).Furthermore, a yeast promoter can include naturally occurring promotersof non-yeast origin that have the ability to bind yeast RNA polymeraseand initiate transcription. Examples of such promoters include, interalia, (Cohen et al. (1980) Proc. Natl. Acad. Sci. USA 77:1078; Henikoffet al. (1981) Nature 283:835; Hollenberg et al. (1981) Curr. TopicsMicrobiol. Immunol. 96:119; Hollenberg et al. (1979) “The Expression ofBacterial Antibiotic Resistance Genes in the Yeast Saccharomycescerevisiae,” in: Plasmids of Medical, Environmental and CommercialImportance (eds. K. N. Timmis and A. Puhler); Mercerau-Puigalon et al.(1980) Gene 11:163; Panthier et al. (1980) Curr. Genet. 2:109;).

A DNA molecule may be expressed intracellularly in yeast. A promotersequence may be directly linked with the DNA molecule, in which case thefirst amino acid at the N-terminus of the recombinant protein willalways be a methionine, which is encoded by the ATG start codon. Ifdesired, methionine at the N-terminus may be cleaved from the protein byin vitro incubation with cyanogen bromide.

Fusion proteins provide an alternative for yeast expression systems, aswell as in mammalian, plant, baculovirus, and bacterial expressionsystems. Usually, a DNA sequence encoding the N-terminal portion of anendogenous yeast protein, or other stable protein, is fused to the 5′end of heterologous coding sequences. Upon expression, this constructwill provide a fusion of the two amino acid sequences. For example, theyeast or human superoxide dismutase (SOD) gene, can be linked at the 5′terminus of a foreign gene and expressed in yeast. The DNA sequence atthe junction of the two amino acid sequences may or may not encode acleavable site. See e.g., EPO Publ. No. 196056. Another example is aubiquitin fusion protein. Such a fusion protein is made with theubiquitin region that preferably retains a site for a processing enzyme(e.g. ubiquitin-specific processing protease) to cleave the ubiquitinfrom the foreign protein. Through this method, therefore, native foreignprotein can be isolated (e.g., WO88/024066).

Alternatively, foreign proteins can also be secreted from the cell intothe growth media by creating chimeric DNA molecules that encode a fusionprotein comprised of a leader sequence fragment that provide forsecretion in yeast of the foreign protein. Preferably, there areprocessing sites encoded between the leader fragment and the foreigngene that can be cleaved either in vivo or in vitro. The leader sequencefragment usually encodes a signal peptide comprised of hydrophobic aminoacids which direct the secretion of the protein from the cell.

DNA encoding suitable signal sequences can be derived from genes forsecreted yeast proteins, such as the yeast invertase gene (EPO Publ. No.012 873; JPO Publ. No. 62:096,086) and the A-factor gene (U.S. Pat. No.4,588,684). Alternatively, leaders of non-yeast origin, such as aninterferon leader, exist that also provide for secretion in yeast (EPOPubl. No. 060 057).

A preferred class of secretion leaders are those that employ a fragmentof the yeast alpha-factor gene, which contains both a “pre” signalsequence, and a “pro” region. The types of alpha-factor fragments thatcan be employed include the full-length pre-pro alpha factor leader(about 83 amino acid residues) as well as truncated alpha-factor leaders(usually about 25 to about 50 amino acid residues) (U.S. Pat. Nos.4,546,083 and 4,870,008; EPO Publ. No. 324 274). Additional leadersemploying an alpha-factor leader fragment that provides for secretioninclude hybrid alpha-factor leaders made with a presequence of a firstyeast, but a pro-region from a second yeast alphafactor. (See e.g., PCTPubl. No. WO 89/02463.)

Usually, transcription termination sequences recognized by yeast areregulatory regions located 3′ to the translation stop codon, and thustogether with the promoter flank the coding sequence. These sequencesdirect the transcription of an mRNA which can be translated into thepolypeptide encoded by the DNA. Examples of transcription terminatorsequence and other yeast-recognized termination sequences, such as thosecoding for glycolytic enzymes.

Usually, the above described components, comprising a promoter, leader(if desired), coding sequence of interest, and transcription terminationsequence, are put together into expression constructs. Expressionconstructs are often maintained in a replicon, such as anextrachromosomal element (e.g., plasmids) capable of stable maintenancein a host, such as yeast or bacteria. The replicon may have tworeplication systems, thus allowing it to be maintained, for example, inyeast for expression and in a prokaryotic host for cloning andamplification. Examples of such yeast-bacteria shuttle vectors includeYEp24 (Botstein et al. (1979) Gene 8:17-24), pC1/1 (Brake et al. (1984)Proc. Natl. Acad. Sci USA 81:4642-4646), and YRp17 (Stinchcomb et al.(1982) J. Mol. Biol. 158:157). In addition, a replicon may be either ahigh or low copy number plasmid. A high copy number plasmid willgenerally have a copy number ranging from about 5 to about 200, andusually about 10 to about 150. A host containing a high copy numberplasmid will preferably have at least about 10, and more preferably atleast about 20. Enter a high or low copy number vector may be selected,depending upon the effect of the vector and the foreign protein on thehost. See e.g., Brake et al., supra.

Alternatively, the expression constructs can be integrated into theyeast genome with an integrating vector. Integrating vectors usuallycontain at least one sequence homologous to a yeast chromosome thatallows the vector to integrate, and preferably contain two homologoussequences flanking the expression construct. Integrations appear toresult from recombinations between homologous DNA in the vector and theyeast chromosome (Orr-Weaver et al. (1983) Methods in Enzymol.101:228-245). An integrating vector may be directed to a specific locusin yeast by selecting the appropriate homologous sequence for inclusionin the vector. See Orr-Weaver et al., supra. One or more expressionconstruct may integrate, possibly affecting levels of recombinantprotein produced (Rine et al. (1983) Proc. Natl. Acad. Sci. USA80:6750). The chromosomal sequences included in the vector can occureither as a single segment in the vector, which results in theintegration of the entire vector, or two segments homologous to adjacentsegments in the chromosome and flanking the expression construct in thevector, which can result in the stable integration of only theexpression construct.

Usually, extrachromosomal and integrating expression constructs maycontain selectable markers to allow for the selection of yeast strainsthat have been transformed. Selectable markers may include biosyntheticgenes that can be expressed in the yeast host, such as ADE2, HIS4, LEU2,TRP1, and ALG7, and the G418 resistance gene, which confer resistance inyeast cells to tunicamycin and G418, respectively. In addition, asuitable selectable marker may also provide yeast with the ability togrow in the presence of toxic compounds, such as metal. For example, thepresence of CUP1 allows yeast to grow in the presence of copper ions(Butt et al. (1987) Microbiol, Rev. 51:351).

Alternatively, some of the above described components can be puttogether into transformation vectors. Transformation vectors are usuallycomprised of a selectable marker that is either maintained in a repliconor developed into an integrating vector, as described above.

Expression and transformation vectors, either extrachromosomal repliconsor integrating vectors, have been developed for transformation into manyyeasts. For example, expression vectors and methods of introducingexogenous DNA into yeast hosts have been developed for, inter alia, thefollowing yeasts: Candida albicans (Kurtz, et al. (1986) Mol. Cell.Biol. 6:142); Candida maltosa (Kunze, et al. (1985) J. Basic Microbiol.25:141); Hansenula polymorpha (Gleeson, et al. (1986) J. Gen. Microbiol.132:3459; Roggenkamp et al. (1986) Mol. Gen. Genet. 202:302);Kluyveromyces fragilis (Das, et al. (1984) J. Bacteriol. 158:1165);Kluyveromyces lactis (De Louvencourt et al. (1983) J. Bacteriol.154:737; Van den Berg et al. (1990) Bio/Technology 8:135); Pichiaguillerimondii (Kunze et al. (1985) J. Basic Microbiol. 25:141); Pichiapastoris (Cregg, et al. (1985) Mol. Cell. Biol. 5:3376; U.S. Pat. Nos.4,837,148 and 4,929,555); Saccharomyces cerevisiae (Hinnen et al. (1978)Proc. Natl. Acad. Sci. USA 75:1929; Ito et al. (1983) J. Bacteriol.153:163); Schizosaccharomyces pombe (Beach and Nurse (1981) Nature300:706); and Yarrowia lipolytica (Davidow, et al. (1985) Curr. Genet.10:380471 Gaillardin, et al. (1985) Curr. Genet. 10:49).

Methods of introducing exogenous DNA into yeast hosts are well-known inthe art, and usually include either the transformation of spheroplastsor of intact yeast cells treated with alkali cations. Transformationprocedures usually vary with the yeast species to be transformed. Seee.g., [Kurtz et al. (1986) Mol. Cell. Biol. 6:142; Kunze et al. (1985)J. Basic Microbiol. 25:141; Candida]; [Gleeson et al. (1986) J. Gen.Microbiol. 132:3459; Roggenkamp et al. (1986) Mol. Gen. Genet. 202:302;Hansenula]; [Das et al. (1984) J. Bacteriol. 158:1165; De Louvencourt etal. (1983) J. Bacteriol. 154:1165; Van den Berg et al. (1990)Bio/Technology 8:135; Kluyveromyces]; [Cregg et al. (1985) Mol. Cell.Biol. 5:3376; Kunze et al. (1985) J. Basic Microbiol. 25:141; U.S. Pat.Nos. 4,837,148 and 4,929,555; Pichia]; [Hinnen et al. (1978) Proc. Natl.Acad. Sci. USA 75; 1929; Ito et al. (1983) J. Bacteriol. 153:163Saccharomyces]; [Beach and Nurse (1981) Nature 300:706;Schizosaccharomyces]; [Davidow et al. (1985) Curr. Genet. 10:39;Gaillardin et al. (1985) Curr. Genet. 10:49; Yarrowia].

DEFINITIONS

A composition containing X is “substantially free of” Y when at least85% by weight of the total X+Y in the composition is X. Preferably, Xcomprises at least about 90% by weight of the total of X+Y in thecomposition, more preferably at least about 95% or even 99% by weight.

A “conserved” Neisseria amino acid fragment or protein is one that ispresent in a particular Neisserial protein in at least x % of Neisseria.The value of x may be 50% or more, e.g., 66%, 75%, 80%, 90%, 95% or even100% (i.e. the amino acid is found in the protein in question in allNeisseria). In order to determine whether an amino acid is “conserved”in a particular Neisserial protein, it is necessary to compare thatamino acid residue in the sequences of the protein in question from aplurality of different Neisseria (a reference population). The referencepopulation may include a number of different Neisseria species or mayinclude a single species. The reference population may include a numberof different serogroups of a particular species or a single serogroup. Apreferred reference population consists of the 5 most common NeisseriaThe term “heterologous” refers to two biological components that are notfound together in nature. The components may be host cells, genes, orregulatory regions, such as promoters. Although the heterologouscomponents are not found together in nature, they can function together,as when a promoter heterologous to a gene is operably linked to thegene. Another example is where a Neisserial sequence is heterologous toa mouse host cell.

An “origin of replication” is a polynucleotide sequence that initiatesand regulates replication of polynucleotides, such as an expressionvector. The origin of replication behaves as an autonomous unit ofpolynucleotide replication within a cell, capable of replication underits own control. An origin of replication may be needed for a vector toreplicate in a particular host cell. With certain origins ofreplication, an expression vector can be reproduced at a high copynumber in the presence of the appropriate proteins within the cell.Examples of origins are the autonomously replicating sequences, whichare effective in yeast; and the viral T-antigen, effective in COS-7cells.

A “mutant” sequence is defined as a DNA, RNA or amino acid sequencediffering from but having homology with the native or disclosedsequence. Depending on the particular sequence, the degree of homology(sequence identity) between the native or disclosed sequence and themutant sequence is preferably greater than 50% (e.g., 60%, 70%, 80%,90%, 95%, 99% or more) which is calculated as described above. As usedherein, an “allelic variant” of a nucleic acid molecule, or region, forwhich nucleic acid sequence is provided herein is a nucleic acidmolecule, or region, that occurs at essentially the same locus in thegenome of another or second isolate, and that, due to natural variationcaused by, for example, mutation or recombination, has a similar but notidentical nucleic acid sequence. A coding region allelic varianttypically encodes a protein having similar activity to that of theprotein encoded by the gene to which it is being compared. An allelicvariant can also comprise an alteration in the 5′ or 3′ untranslatedregions of the gene, such as in regulatory control regions. (see, forexample, U.S. Pat. No. 5,753,235).

Antibodies

As used herein, the term “antibody” refers to a polypeptide or group ofpolypeptides composed of at least one antibody combining site. An“antibody combining site” is the three-dimensional binding space with aninternal surface shape and charge distribution complementary to thefeatures of an epitope of an antigen, which allows a binding of theantibody with the antigen. “Antibody” includes, for example, vertebrateantibodies, hybrid antibodies, chimeric antibodies, humanizedantibodies, altered antibodies, univalent antibodies, Fab proteins, andsingle domain antibodies.

Antibodies against the proteins of the invention are useful for affinitychromatography, immunoassays, and distinguishing/identifying NeisseriamenB proteins. Antibodies elicited against the proteins of the presentinvention bind to antigenic polypeptides or proteins or proteinfragments that are present and specifically associated with strains ofNeisseria meningitidis menB. In some instances, these antigens may beassociated with specific strains, such as those antigens specific forthe menB strains. The antibodies of the invention may be immobilized toa matrix and utilized in an immunoassay or on an affinity chromatographycolumn, to enable the detection and/or separation of polypeptides,proteins or protein fragments or cells comprising such polypeptides,proteins or protein fragments. Alternatively, such polypeptides,proteins or protein fragments may be immobilized so as to detectantibodies bindably specific thereto.

Antibodies to the proteins of the invention, both polyclonal andmonoclonal, may be prepared by conventional methods. In general, theprotein is first used to immunize a suitable animal, preferably a mouse,rat, rabbit or goat. Rabbits and goats are preferred for the preparationof polyclonal sera due to the volume of serum obtainable, and theavailability of labeled anti-rabbit and anti-goat antibodies.Immunization is generally performed by mixing or emulsifying the proteinin saline, preferably in an adjuvant such as Freund's complete adjuvant,and injecting the mixture or emulsion parenterally (generallysubcutaneously or intramuscularly). A dose of 50-200 μg/injection istypically sufficient. Immunization is generally boosted 2-6 weeks laterwith one or more injections of the protein in saline, preferably usingFreund's incomplete adjuvant. One may alternatively generate antibodiesby in vitro immunization using methods known in the art, which for thepurposes of this invention is considered equivalent to in vivoimmunization. Polyclonal antisera is obtained by bleeding the immunizedanimal into a glass or plastic container, incubating the blood at 25° C.for one hour, followed by incubating at 4° C. for 2-18 hours. The serumis recovered by centrifugation (e.g., 1,000 g for 10 minutes). About20-50 ml per bleed may be obtained from rabbits.

Monoclonal antibodies are prepared using the standard method of Kohler &Milstein (Nature (1975) 256:495-96), or a modification thereof.Typically, a mouse or rat is immunized as described above. However,rather than bleeding the animal to extract serum, the spleen (andoptionally several large lymph nodes) is removed and dissociated intosingle cells. If desired, the spleen cells may be screened (afterremoval of nonspecifically adherent cells) by applying a cell suspensionto a plate or well coated with the protein antigen. B-cells that expressmembrane-bound immunoglobulin specific for the antigen bind to theplate, and are not rinsed away with the rest of the suspension.Resulting B-cells, or all dissociated spleen cells, are then induced tofuse with myeloma cells to form hybridomas, and are cultured in aselective medium (e.g., hypoxanthine, aminopterin, thymidine medium,“HAT”). The resulting hybridomas are plated by limiting dilution, andare assayed for the production of antibodies which bind specifically tothe immunizing antigen (and which do not bind to unrelated antigens).The selected MAb-secreting hybridomas are then cultured either in vitro(e.g., in tissue culture bottles or hollow fiber reactors), or in vivo(as ascites in mice).

If desired, the antibodies (whether polyclonal or monoclonal) may belabeled using conventional techniques. Suitable labels includefluorophores, chromophores, radioactive atoms (particularly ³²P and¹²⁵I), electron-dense reagents, enzymes, and ligands having specificbinding partners. Enzymes are typically detected by their activity. Forexample, horseradish peroxidase is usually detected by its ability toconvert 3,3′,5,5′-tetramethylbenzidine (TMB) to a blue pigment,quantifiable with a spectrophotometer. “Specific binding partner” refersto a protein capable of binding a ligand molecule with high specificity,as for example in the case of an antigen and a monoclonal antibodyspecific therefor. Other specific binding partners include biotin andavidin or streptavidin, IgG and protein A, and the numerousreceptor-ligand couples known in the art. It should be understood thatthe above description is not meant to categorize the various labels intodistinct classes, as the same label may serve in several differentmodes. For example, ¹²⁵I may serve as a radioactive label or as anelectron-dense reagent. HRP may serve as enzyme or as antigen for a MAb.Further, one may combine various labels for desired effect. For example,MAbs and avidin also require labels in the practice of this invention:thus, one might label a MAb with biotin, and detect its presence withavidin labeled with ¹²⁵I, or with an anti-biotin MAb labeled with HRP.Other permutations and possibilities will be readily apparent to thoseof ordinary skill in the art, and are considered as equivalents withinthe scope of the instant invention.

Antigens, immunogens, polypeptides, proteins or protein fragments of thepresent invention elicit formation of specific binding partnerantibodies. These antigens, immunogens, polypeptides, proteins orprotein fragments of the present invention comprise immunogeniccompositions of the present invention. Such immunogenic compositions mayfurther comprise or include adjuvants, carriers, or other compositionsthat promote or enhance or stabilize the antigens, polypeptides,proteins or protein fragments of the present invention. Such adjuvantsand carriers will be readily apparent to those of ordinary skill in theart.

Pharmaceutical Compositions

Pharmaceutical compositions can comprise (include) either polypeptides,antibodies, or nucleic acid of the invention. The pharmaceuticalcompositions will comprise a therapeutically effective amount of eitherpolypeptides, antibodies, or polynucleotides of the claimed invention.

The term “therapeutically effective amount” as used herein refers to anamount of a therapeutic agent to treat, ameliorate, or prevent a desireddisease or condition, or to exhibit a detectable therapeutic orpreventative effect. The effect can be detected by, for example,chemical markers or antigen levels. Therapeutic effects also includereduction in physical symptoms, such as decreased body temperature, whengiven to a patient that is febrile. The precise effective amount for asubject will depend upon the subject's size and health, the nature andextent of the condition, and the therapeutics or combination oftherapeutics selected for administration. Thus, it is not useful tospecify an exact effective amount in advance. However, the effectiveamount for a given situation can be determined by routineexperimentation and is within the judgment of the clinician.

For purposes of the present invention, an effective dose will be fromabout 0.01 mg/kg to 50 mg/kg or 0.05 mg/kg to about 10 mg/kg of the DNAconstructs in the individual to which it is administered.

A pharmaceutical composition can also contain a pharmaceuticallyacceptable carrier. The term “pharmaceutically acceptable carrier”refers to a carrier for administration of a therapeutic agent, such asantibodies or a polypeptide, genes, and other therapeutic agents. Theterm refers to any pharmaceutical carrier that does not itself inducethe production of antibodies harmful to the individual receiving thecomposition, and which may be administered without undue toxicity.Suitable carriers may be large, slowly metabolized macromolecules suchas proteins, polysaccharides, polylactic acids, polyglycolic acids,polymeric amino acids, amino acid copolymers, and inactive virusparticles. Such carriers are well known to those of ordinary skill inthe art.

Pharmaceutically acceptable salts can be used therein, for example,mineral acid salts such as hydrochlorides, hydrobromides, phosphates,sulfates, and the like; and the salts of organic acids such as acetates,propionates, malonates, benzoates, and the like. A thorough discussionof pharmaceutically acceptable excipients is available in Remington'sPharmaceutical Sciences (Mack Pub. Co., N.J. 1991).

Pharmaceutically acceptable carriers in therapeutic compositions maycontain liquids such as water, saline, glycerol and ethanol.Additionally, auxiliary substances, such as wetting or emulsifyingagents, pH buffering substances, and the like, may be present in suchvehicles. Typically, the therapeutic compositions are prepared asinjectables, either as liquid solutions or suspensions; solid formssuitable for solution in, or suspension in, liquid vehicles prior toinjection may also be prepared. Liposomes are included within thedefinition of a pharmaceutically acceptable carrier.

Delivery Methods

Once formulated, the compositions of the invention can be administereddirectly to the subject. The subjects to be treated can be animals; inparticular, human subjects can be treated.

Direct delivery of the compositions will generally be accomplished byinjection, either subcutaneously, intraperitoneally, intravenously orintramuscularly or delivered to the interstitial space of a tissue. Thecompositions can also be administered into a lesion. Other modes ofadministration include oral and pulmonary administration, suppositories,and transdermal and transcutaneous applications, needles, and gene gunsor hyposprays. Dosage treatment may be a single dose schedule or amultiple dose schedule.

Vaccines

Vaccines according to the invention may either be prophylactic (i.e., toprevent infection) or therapeutic (i.e., to treat disease afterinfection).

Such vaccines comprise immunizing antigen(s) or immunogen(s),immunogenic polypeptide, protein(s) or protein fragments, or nucleicacids (e.g., ribonucleic acid or deoxyribonucleic acid), usually incombination with “pharmaceutically acceptable carriers,” which includeany carrier that does not itself induce the production of antibodiesharmful to the individual receiving the composition. Suitable carriersare typically large, slowly metabolized macromolecules such as proteins,polysaccharides, polylactic acids, polyglycolic acids, polymeric aminoacids, amino acid copolymers, lipid aggregates (such as oil droplets orliposomes), and inactive virus particles. Such carriers are well knownto those of ordinary skill in the art. Additionally, these carriers mayfunction as immunostimulating agents (“adjuvants”). Furthermore, theimmunogen or antigen may be conjugated to a bacterial toxoid, such as atoxoid from diphtheria, tetanus, cholera, H. pylori, etc. pathogens.

Preferred adjuvants to enhance effectiveness of the composition include,but are not limited to: (1) aluminum salts (alum), such as aluminumhydroxide, aluminum phosphate, aluminum sulfate, etc; (2) oil-in-wateremulsion formulations (with or without other specific immunostimulatingagents such as muramyl peptides (see below) or bacterial cell wallcomponents), such as for example (a) MF59 (PCT Publ. No. WO 90/14837),containing 5% Squalene, 0.5% TWEEN 80™, and 0.5% SPAN 85™ (optionallycontaining various amounts of MTP-PE (see below), although not required)formulated into submicron particles using a microfluidizer such as Model110Y microfluidizer (Microfluidics, Newton, Mass.), (b) SAF, containing10% Squalane, 0.4% Tween 80, 5% PLURONIC™-blocked polymer L121, andthr-MDP (see below) either microfluidized into a submicron emulsion orvortexed to generate a larger particle size emulsion, and (c) RIBI™adjuvant system (RAS), (Ribi Immunochem, Hamilton, Mont.) containing 2%Squalene, 0.2% TWEEN 80™, and one or more bacterial cell wall componentsfrom the group consisting of monophosphorylipid A (MPL), trehalosedimycolate (TDM), and cell wall skeleton (CWS), preferably MPL+CWS(DETOX™); (3) saponin adjuvants, such as STIMULON™ (CambridgeBioscience, Worcester, Mass.) may be used or particles generatedtherefrom such as ISCOMs (immunostimulating complexes); (4) CompleteFreund's Adjuvant (CFA) and Incomplete Freund's Adjuvant (IFA); (5)cytokines, such as interleukins (e.g., IL-1, IL-2, IL-4, IL-5, IL-6,IL-7, IL-12, etc.), interferons (e.g., gamma interferon), macrophagecolony stimulating factor (M-CSF), tumor necrosis factor (TNF), etc; and(6) other substances that act as immunostimulating agents to enhance theeffectiveness of the composition. Alum and MF59 are preferred.

As mentioned above, muramyl peptides include, but are not limited to,N-acetyl-muramyl-L-threonyl-D-isoglutamine (thr-MDP),N-acetyl-normuramyl-L-alanyl-D-isoglutamine (nor-MDP),N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine-2-(1′-2′-dipalmitoyl-sn-glycero-3-huydroxyphosphoryloxy)-ethylamine(MTP-PE), etc.

The vaccine compositions comprising immunogenic compositions (e.g.,which may include the antigen, pharmaceutically acceptable carrier, andadjuvant) typically will contain diluents, such as water, saline,glycerol, ethanol, etc. Additionally, auxiliary substances, such aswetting or emulsifying agents, pH buffering substances, and the like,may be present in such vehicles. Alternatively, vaccine compositionscomprising immunogenic compositions may comprise an antigen,polypeptide, protein, protein fragment or nucleic acid in apharmaceutically acceptable carrier.

More specifically, vaccines comprising immunogenic compositions comprisean immunologically effective amount of the immunogenic polypeptides, aswell as any other of the above-mentioned components, as needed. By“immunologically effective amount”, it is meant that the administrationof that amount to an individual, either in a single dose or as part of aseries, is effective for treatment or prevention. This amount variesdepending upon the health and physical condition of the individual to betreated, the taxonomic group of individual to be treated (e.g., nonhumanprimate, primate, etc.), the capacity of the individual's immune systemto synthesize antibodies, the degree of protection desired, theformulation of the vaccine, the treating doctor's assessment of themedical situation, and other relevant factors. It is expected that theamount will fall in a relatively broad range that can be determinedthrough routine trials.

Typically, the vaccine compositions or immunogenic compositions areprepared as injectables, either as liquid solutions or suspensions;solid forms suitable for solution in, or suspension in, liquid vehiclesprior to injection may also be prepared. The preparation also may beemulsified or encapsulated in liposomes for enhanced adjuvant effect, asdiscussed above under pharmaceutically acceptable carriers.

The immunogenic compositions are conventionally administeredparenterally, e.g., by injection, either subcutaneously orintramuscularly. Additional formulations suitable for other modes ofadministration include oral and pulmonary formulations, suppositories,and transdermal and transcutaneous applications. Dosage treatment may bea single dose schedule or a multiple dose schedule. The vaccine may beadministered in conjunction with other immunoregulatory agents.

As an alternative to protein-based vaccines, DNA vaccination may beemployed (e.g., Robinson & Torres (1997) Seminars in Immunology9:271-283; Donnelly et al. (1997) Annu Rev Immunol 15:617-648).

Gene Delivery Vehicles

Gene therapy vehicles for delivery of constructs, including a codingsequence of a therapeutic of the invention, to be delivered to themammal for expression in the mammal, can be administered either locallyor systemically. These constructs can utilize viral or non-viral vectorapproaches in in vivo or ex vivo modality. Expression of such codingsequence can be induced using endogenous mammalian or heterologouspromoters. Expression of the coding sequence in vivo can be eitherconstitutive or regulated.

The invention includes gene delivery vehicles capable of expressing thecontemplated nucleic acid sequences. The gene delivery vehicle ispreferably a viral vector and, more preferably, a retroviral,adenoviral, adeno-associated viral (AAV), herpes viral, or alphavirusvector. The viral vector can also be an astrovirus, coronavirus,orthomyxovirus, papovavirus, paramyxovirus, parvovirus, picornavirus,poxvirus, or togavirus viral vector. See generally, Jolly (1994) CancerGene Therapy 1:51-64; Kimura (1994) Human Gene Therapy 5:845-852;Connelly (1995) Human Gene Therapy 6:185-193; and Kaplitt (1994) NatureGenetics 6:148-153.

Retroviral vectors are well known in the art, including B, C and D typeretroviruses, xenotropic retroviruses (for example, NZB-X1, NZB-X2 andNZB9-1 (see O'Neill (1985) J. Virol. 53:160) polytropic retrovirusese.g., MCF and MCF-MLV (see Kelly (1983) J. Virol. 45:291), spumavirusesand lentiviruses. See RNA Tumor Viruses, Second Edition, Cold SpringHarbor Laboratory, 1985.

Portions of the retroviral gene therapy vector may be derived fromdifferent retroviruses. For example, retrovector LTRs may be derivedfrom a Murine Sarcoma Virus, a tRNA binding site from a Rous SarcomaVirus, a packaging signal from a Murine Leukemia Virus, and an origin ofsecond strand synthesis from an Avian Leukosis Virus.

These recombinant retroviral vectors may be used to generatetransduction competent retroviral vector particles by introducing theminto appropriate packaging cell lines (see U.S. Pat. No. 5,591,624).Retrovirus vectors can be constructed for site-specific integration intohost cell DNA by incorporation of a chimeric integrase enzyme into theretroviral particle (see WO96/37626). It is preferable that therecombinant viral vector is a replication defective recombinant virus.

Packaging cell lines suitable for use with the above-describedretrovirus vectors are well known in the art, are readily prepared (seeWO95/30763 and WO92/05266), and can be used to create producer celllines (also termed vector cell lines or “VCLs”) for the production ofrecombinant vector particles. Preferably, the packaging cell lines aremade from human parent cells (e.g., HT1080 cells) or mink parent celllines, which eliminates inactivation in human serum.

Preferred retroviruses for the construction of retroviral gene therapyvectors include Avian Leukosis Virus, Bovine Leukemia Virus, MurineLeukemia Virus, Mink-Cell Focus-Inducing Virus, Murine Sarcoma Virus,Reticuloendotheliosis Virus and Rous Sarcoma Virus. Particularlypreferred Murine Leukemia Viruses include 4070A and 1504A (Hartley andRowe (1976) J Virol 19:19-25), Abelson (ATCC No. VR-999), Friend (ATCCNo. VR-245), Graffi, Gross (ATCC Nol VR-590), Kirsten, Harvey SarcomaVirus and Rauscher (ATCC No. VR-998) and Moloney Murine Leukemia Virus(ATCC No. VR-190). Such retroviruses may be obtained from depositoriesor collections such as the American Type Culture Collection (“ATCC”) orisolated from known sources using commonly available techniques.

Exemplary known retroviral gene therapy vectors employable in thisinvention include those described in patent applications GB2200651,EP0415731, EP0345242, EP0334301, WO89/02468; WO89/05349, WO89/09271,WO90/02806, WO90/07936, WO94/03622, WO93/25698, WO93/25234, WO93/11230,WO93/10218, WO91/02805, WO91/02825, WO95/07994, U.S. Pat. No. 5,219,740,U.S. Pat. No. 4,405,712, U.S. Pat. No. 4,861,719, U.S. Pat. No.4,980,289, U.S. Pat. No. 4,777,127, U.S. Pat. No. 5,591,624. See alsoVile (1993) Cancer Res 53:3860-3864; Vile (1993) Cancer Res 53:962-967;Ram (1993) Cancer Res 53 (1993) 83-88; Takamiya (1992) J Neurosci Res33:493-503; Baba (1993) J Neurosurg 79:729-735; Mann (1983) Cell 33:153;Cane (1984) Proc Natl Acad Sci 81:6349; and Miller (1990) Human GeneTherapy 1.

Human adenoviral gene therapy vectors are also known in the art andemployable in this invention. See, for example, Berkner (1988)Biotechniques 6:616 and Rosenfeld (1991) Science 252:431, andWO93/07283, WO93/06223, and WO93/07282. Exemplary known adenoviral genetherapy vectors employable in this invention include those described inthe above referenced documents and in WO94/12649, WO93/03769,WO93/19191, WO94/28938, WO95/11984, WO95/00655, WO95/27071, WO95/29993,WO95/34671, WO96/05320, WO94/08026, WO94/11506, WO93/06223, WO94/24299,WO95/14102, WO95/24297, WO95/02697, WO94/28152, WO94/24299, WO95/09241,WO95/25807, WO95/05835, WO94/18922 and WO95/09654. Alternatively,administration of DNA linked to killed adenovirus as described in Curiel(1992) Hum. Gene Ther. 3:147-154 may be employed. The gene deliveryvehicles of the invention also include adenovirus associated virus (AAV)vectors. Leading and preferred examples of such vectors for use in thisinvention are the AAV-2 based vectors disclosed in Srivastava,WO93/09239. Most preferred AAV vectors comprise the two AAV invertedterminal repeats in which the native D-sequences are modified bysubstitution of nucleotides, such that at least 5 native nucleotides andup to 18 native nucleotides, preferably at least 10 native nucleotidesup to 18 native nucleotides, most preferably 10 native nucleotides areretained and the remaining nucleotides of the D-sequence are deleted orreplaced with non-native nucleotides. The native D-sequences of the AAVinverted terminal repeats are sequences of 20 consecutive nucleotides ineach AAV inverted terminal repeat (i.e., there is one sequence at eachend) which are not involved in HP formation. The non-native replacementnucleotide may be any nucleotide other than the nucleotide found in thenative D-sequence in the same position. Other employable exemplary AAVvectors are pWP-19, pWN-1, both of which are disclosed in Nahreini(1993) Gene 124:257-262. Another example of such an AAV vector ispsub201 (see Samulski (1987) J. Virol. 61:3096). Another exemplary AAVvector is the Double-D ITR vector. Construction of the Double-D ITRvector is disclosed in U.S. Pat. No. 5,478,745. Still other vectors arethose disclosed in Carter U.S. Pat. No. 4,797,368 and Muzyczka U.S. Pat.No. 5,139,941, Chartejee U.S. Pat. No. 5,474,935, and Kotin WO94/288157.Yet a further example of an AAV vector employable in this invention isSSV9AFABTKneo, which contains the AFP enhancer and albumin promoter anddirects expression predominantly in the liver. Its structure andconstruction are disclosed in Su (1996) Human Gene Therapy 7:463-470.Additional AAV gene therapy vectors are described in U.S. Pat. No.5,354,678, U.S. Pat. No. 5,173,414, U.S. Pat. No. 5,139,941, and U.S.Pat. No. 5,252,479.

The gene therapy vectors comprising sequences of the invention alsoinclude herpes vectors. Leading and preferred examples are herpessimplex virus vectors containing a sequence encoding a thymidine kinasepolypeptide such as those disclosed in U.S. Pat. No. 5,288,641 andEP0176170 (Roizman). Additional exemplary herpes simplex virus vectorsinclude HFEM/ICP6-LacZ disclosed in WO95/04139 (Wistar Institute),pHSVlac described in Geller (1988) Science 241:1667-1669 and inWO90/09441 and WO92/07945, HSV Us3:pgC-lacZ described in Fink (1992)Human Gene Therapy 3:11-19 and HSV 7134, 2 RH 105 and GAL4 described inEP 0453242 (Breakefield), and those deposited with the ATCC as accessionnumbers ATCC VR-977 and ATCC VR-260.

Also contemplated are alpha virus gene therapy vectors that can beemployed in this invention. Preferred alpha virus vectors are Sindbisviruses vectors. Togaviruses, Semliki Forest virus (ATCC VR-67; ATCCVR-1247), Middleberg virus (ATCC VR-370), Ross River virus (ATCC VR-373;ATCC VR-1246), Venezuelan equine encephalitis virus (ATCC VR923; ATCCVR-1250; ATCC VR-1249; ATCC VR-532), and those described in U.S. Pat.Nos. 5,091,309, 5,217,879, and WO92/10578. More particularly, thosealpha virus vectors described in U.S. Ser. No. 08/405,627, filed Mar.15, 1995, WO94/21792, WO92/10578, WO95/07994, U.S. Pat. No. 5,091,309and U.S. Pat. No. 5,217,879 are employable. Such alpha viruses may beobtained from depositories or collections such as the ATCC or isolatedfrom known sources using commonly available techniques. Preferably,alphavirus vectors with reduced cytotoxicity are used (see U.S. Ser. No.08/679,640).

DNA vector systems such as eukarytic layered expression systems are alsouseful for expressing the nucleic acids of the invention. See WO95/07994for a detailed description of eukaryotic layered expression systems.Preferably, the eukaryotic layered expression systems of the inventionare derived from alphavirus vectors and most preferably from Sindbisviral vectors.

Other viral vectors suitable for use in the present invention includethose derived from poliovirus, for example ATCC VR-58 and thosedescribed in Evans, Nature 339 (1989) 385 and Sabin (1973) J. Biol.Standardization 1:115; rhinovirus, for example ATCC VR-1110 and thosedescribed in Arnold (1990) J Cell Biochem L401; pox viruses such ascanary pox virus or vaccinia virus, for example ATCC VR-111 and ATCCVR-2010 and those described in Fisher-Hoch (1989) Proc Natl Acad Sci86:317; Flexner (1989) Ann NY Acad Sci 569:86, Flexner (1990) Vaccine8:17; in U.S. Pat. No. 4,603,112 and U.S. Pat. No. 4,769,330 andWO89/01973; SV40 virus, for example ATCC VR-305 and those described inMulligan (1979) Nature 277:108 and Madzak (1992) J Gen Virol 73:1533;influenza virus, for example ATCC VR-797 and recombinant influenzaviruses made employing reverse genetics techniques as described in U.S.Pat. No. 5,166,057 and in Enami (1990) Proc Natl Acad Sci 87:3802-3805;Enami & Palese (1991) J Virol 65:2711-2713 and Luytjes (1989) Cell59:110, (see also McMichael (1983) NEJ Med 309:13, and Yap (1978) Nature273:238 and Nature (1979) 277:108); human immunodeficiency virus asdescribed in EP-0386882 and in Buchschacher (1992) J. Virol. 66:2731;measles virus, for example ATCC VR-67 and VR-1247 and those described inEP-0440219; Aura virus, for example ATCC VR-368; Bebaru virus, forexample ATCC VR-600 and ATCC VR-1240; Cabassou virus, for example ATCCVR-922; Chikungunya virus, for example ATCC VR-64 and ATCC VR-1241; FortMorgan Virus, for example ATCC VR-924; Getah virus, for example ATCCVR-369 and ATCC VR-1243; Kyzylagach virus, for example ATCC VR-927;Mayaro virus, for example ATCC VR-66; Mucambo virus, for example ATCCVR-580 and ATCC VR-1244; Ndumu virus, for example ATCC VR-371; Pixunavirus, for example ATCC VR-372 and ATCC VR-1245; Tonate virus, forexample ATCC VR-925; Triniti virus, for example ATCC VR-469; Una virus,for example ATCC VR-374; Whataroa virus, for example ATCC VR-926;Y-62-33 virus, for example ATCC VR-375; O'Nyong virus, Easternencephalitis virus, for example ATCC VR-65 and ATCC VR-1242; Westernencephalitis virus, for example ATCC VR-70, ATCC VR-1251, ATCC VR-622and ATCC VR-1252; and coronavirus, for example ATCC VR-740 and thosedescribed in Hamre (1966) Proc Soc Exp Biol Med 121:190.

Delivery of the compositions of this invention into cells is not limitedto the above mentioned viral vectors. Other delivery methods and mediamay be employed such as, for example, nucleic acid expression vectors,polycationic condensed DNA linked or unlinked to killed adenovirusalone, for example see U.S. Ser. No. 08/366,787, filed Dec. 30, 1994 andCuriel (1992) Hum Gene Ther 3:147-154 ligand linked DNA, for example seeWu (1989) J Biol Chem 264:16985-16987, eucaryotic cell delivery vehiclescells, for example see U.S. Ser. No. 08/240,030, filed May 9, 1994, andU.S. Ser. No. 08/404,796, deposition of photopolymerized hydrogelmaterials, hand-held gene transfer particle gun, as described in U.S.Pat. No. 5,149,655, ionizing radiation as described in U.S. Pat. No.5,206,152 and in WO92/11033, nucleic charge neutralization or fusionwith cell membranes. Additional approaches are described in Philip(1994) Mol Cell Biol 14:2411-2418 and in Woffendin (1994) Proc Natl AcadSci 91:1581-1585.

Particle mediated gene transfer may be employed, for example see U.S.Ser. No. 60/023,867. Briefly, the sequence can be inserted intoconventional vectors that contain conventional control sequences forhigh level expression, and then incubated with synthetic gene transfermolecules such as polymeric DNA-binding cations like polylysine,protamine, and albumin, linked to cell targeting ligands such asasialoorosomucoid, as described in Wu & Wu (1987) J. Biol. Chem.262:4429-4432, insulin as described in Hucked (1990) Biochem Pharmacol40:253-263, galactose as described in Plank (1992) Bioconjugate Chem3:533-539, lactose or transferrin.

Naked DNA may also be employed to transform a host cell. Exemplary nakedDNA introduction methods are described in WO 90/11092 and U.S. Pat. No.5,580,859. Uptake efficiency may be improved using biodegradable latexbeads. DNA coated latex beads are efficiently transported into cellsafter endocytosis initiation by the beads. The method may be improvedfurther by treatment of the beads to increase hydrophobicity and therebyfacilitate disruption of the endosome and release of the DNA into thecytoplasm.

Liposomes that can act as gene delivery vehicles are described in U.S.Pat. No. 5,422,120, WO95/13796, WO94/23697, WO91/14445 and EP-524,968.As described in U.S. Ser. No. 60/023,867, on non-viral delivery, thenucleic acid sequences encoding a polypeptide can be inserted intoconventional vectors that contain conventional control sequences forhigh level expression, and then be incubated with synthetic genetransfer molecules such as polymeric DNA-binding cations likepolylysine, protamine, and albumin, linked to cell targeting ligandssuch as asialoorosomucoid, insulin, galactose, lactose, or transferrin.Other delivery systems include the use of liposomes to encapsulate DNAcomprising the gene under the control of a variety of tissue-specific orubiquitously-active promoters. Further non-viral delivery suitable foruse includes mechanical delivery systems such as the approach describedin Woffendin et al (1994) Proc. Natl. Acad. Sci. USA 91(24):11581-11585.Moreover, the coding sequence and the product of expression of such canbe delivered through deposition of photopolymerized hydrogel materials.Other conventional methods for gene delivery that can be used fordelivery of the coding sequence include, for example, use of hand-heldgene transfer particle gun, as described in U.S. Pat. No. 5,149,655; useof ionizing radiation for activating transferred gene, as described inU.S. Pat. No. 5,206,152 and WO92/11033.

Exemplary liposome and polycationic gene delivery vehicles are thosedescribed in U.S. Pat. Nos. 5,422,120 and 4,762,915; in WO 95/13796;WO94/23697; and WO91/14445; in EP-0524968; and in Stryer, Biochemistry,pages 236-240 (1975) W.H. Freeman, San Francisco; Szoka (1980) BiochemBiophys Acta 600:1; Bayer (1979) Biochem Biophys Acta 550:464; Rivnay(1987) Meth Enzymol 149:119; Wang (1987) Proc Natl Acad Sci 84:7851;Plant (1989) Anal Biochem 176:420.

A polynucleotide composition can comprises therapeutically effectiveamount of a gene therapy vehicle, as the term is defined above. Forpurposes of the present invention, an effective dose will be from about0.01 mg/kg to 50 mg/kg or 0.05 mg/kg to about 10 mg/kg of the DNAconstructs in the individual to which it is administered.

Delivery Methods

Once formulated, the polynucleotide compositions of the invention can beadministered (1) directly to the subject; (2) delivered ex vivo, tocells derived from the subject; or (3) in vitro for expression ofrecombinant proteins. The subjects to be treated can be mammals orbirds. Also, human subjects can be treated.

Direct delivery of the compositions will generally be accomplished byinjection, either subcutaneously, intraperitoneally, intravenously orintramuscularly or delivered to the interstitial space of a tissue. Thecompositions can also be administered into a tumor or lesion. Othermodes of administration include oral and pulmonary administration,suppositories, and transdermal applications, needles, and gene guns orhyposprays. Dosage treatment may be a single dose schedule or a multipledose schedule.

Methods for the ex vivo delivery and reimplantation of transformed cellsinto a subject are known in the art and described in eg. WO93/14778.Examples of cells useful in ex vivo applications include, for example,stem cells, particularly hematopoetic, lymph cells, macrophages,dendritic cells, or tumor cells.

Generally, delivery of nucleic acids for both ex vivo and in vitroapplications can be accomplished by the following procedures, forexample, dextran-mediated transfection, calcium phosphate precipitation,polybrene mediated transfection, protoplast fusion, electroporation,encapsulation of the polynucleotide(s) in liposomes, and directmicroinjection of the DNA into nuclei, all well known in the art.

Polynucleotide and Polypeptide Pharmaceutical Compositions

In addition to the pharmaceutically acceptable carriers and saltsdescribed above, the following additional agents can be used withpolynucleotide and/or polypeptide compositions.

A. Polypeptides

One example are polypeptides which include, without limitation:asioloorosomucoid (ASOR); transferrin; asialoglycoproteins; antibodies;antibody fragments; ferritin; interleukins; interferons, granulocyte,macrophage colony stimulating factor (GM-CSF), granulocyte colonystimulating factor (G-CSF), macrophage colony stimulating factor(M-CSF), stem cell factor and erythropoietin. Viral antigens, such asenvelope proteins, can also be used. Also, proteins from other invasiveorganisms, such as the 17 amino acid peptide from the circumsporozoiteprotein of plasmodium falciparum known as RII.

B. Hormones, Vitamins, Etc.

Other groups that can be included are, for example: hormones, steroids,androgens, estrogens, thyroid hormone, or vitamins, folic acid.

C. Polyalkylenes, Polysaccharides, Etc.

Also, polyalkylene glycol can be included with the desiredpolynucleotides or polypeptides. In a preferred embodiment, thepolyalkylene glycol is polyethlylene glycol. In addition, mono-, di-, orpolysaccarides can be included. In a preferred embodiment of thisaspect, the polysaccharide is dextran or DEAE-dextran. Also, chitosanand poly(lactide-co-glycolide)

D. Lipids, and Liposomes

The desired polynucleotide or polypeptide can also be encapsulated inlipids or packaged in liposomes prior to delivery to the subject or tocells derived therefrom.

Lipid encapsulation is generally accomplished using liposomes which areable to stably bind or entrap and retain nucleic acid. The ratio ofcondensed polynucleotide or polypeptide to lipid preparation can varybut will generally be around 1:1 (mg DNA:micromoles lipid), or more oflipid. For a review of the use of liposomes as carriers for delivery ofnucleic acids, see, Hug and Sleight (1991) Biochim. Biophys. Acta.1097:1-17; Straubinger (1983) Meth. Enzymol. 101:512-527.

Liposomal preparations for use in the present invention include cationic(positively charged), anionic (negatively charged) and neutralpreparations. Cationic liposomes have been shown to mediateintracellular delivery of plasmid DNA (Felgner (1987) Proc. Natl. Acad.Sci. USA 84:7413-7416); mRNA (Malone (1989) Proc. Natl. Acad. Sci. USA86:6077-6081); and purified transcription factors (Debs (1990) J. Biol.Chem. 265:10189-10192), in functional form.

Cationic liposomes are readily available. For example,N[1-2,3-dioleyloxy)propyl]-N,N,N-triethylammonium (DOTMA) liposomes areavailable under the trademark Lipofectin, from GIBCO BRL, Grand Island,N.Y. (See, also, Felgner supra). Other commercially available liposomesinclude transfectace (DDAB/DOPE) and DOTAP/DOPE (Boerhinger). Othercationic liposomes can be prepared from readily available materialsusing techniques well known in the art. See, eg. Szoka (1978) Proc.Natl. Acad. Sci. USA 75:4194-4198; WO90/11092 for a description of thesynthesis of DOTAP (1,2-bis(oleoyloxy)-3-(trimethylammonio)propane)liposomes.

Similarly, anionic and neutral liposomes are readily available, such asfrom Avanti Polar Lipids (Birmingham, Ala.), or can be easily preparedusing readily available materials. Such materials include phosphatidylcholine, cholesterol, phosphatidyl ethanolamine, dioleoylphosphatidylcholine (DOPC), dioleoylphosphatidyl glycerol (DOPG),dioleoylphoshatidyl ethanolamine (DOPE), among others. These materialscan also be mixed with the DOTMA and DOTAP starting materials inappropriate ratios. Methods for making liposomes using these materialsare well known in the art.

The liposomes can comprise multilammelar vesicles (MLVs), smallunilamellar vesicles (SUVs), or large unilamellar vesicles (LUVs). Thevarious liposome-nucleic acid complexes are prepared using methods knownin the art. See eg. Straubinger (1983) Meth. Immunol. 101:512-527; Szoka(1978) Proc. Natl. Acad. Sci. USA 75:4194-4198; Papahadjopoulos (1975)Biochim. Biophys. Acta 394:483; Wilson (1979) Cell 17:77); Deamer &Bangham (1976) Biochim. Biophys. Acta 443:629; Ostro (1977) Biochem.Biophys. Res. Commun. 76:836; Fraley (1979) Proc. Natl. Acad. Sci. USA76:3348); Enoch & Strittmatter (1979) Proc. Natl. Acad. Sci. USA 76:145;Fraley (1980) J. Biol. Chem. (1980) 255:10431; Szoka & Papahadjopoulos(1978) Proc. Natl. Acad. Sci. USA 75:145; and Schaefer-Ridder (1982)Science 215:166.

E. Lipoproteins

In addition, lipoproteins can be included with the polynucleotide orpolypeptide to be delivered. Examples of lipoproteins to be utilizedinclude: chylomicrons, HDL, IDL, LDL, and VLDL. Mutants, fragments, orfusions of these proteins can also be used. Also, modifications ofnaturally occurring lipoproteins can be used, such as acetylated LDL.These lipoproteins can target the delivery of polynucleotides to cellsexpressing lipoprotein receptors. Preferably, if lipoproteins areincluding with the polynucleotide to be delivered, no other targetingligand is included in the composition.

Naturally occurring lipoproteins comprise a lipid and a protein portion.The protein portion are known as apoproteins. At the present,apoproteins A, B, C, D, and E have been isolated and identified. Atleast two of these contain several proteins, designated by Romannumerals, AI, AII, AIV; CI, CII, CIII.

A lipoprotein can comprise more than one apoprotein. For example,naturally occurring chylomicrons comprises of A, B, C, and E, over timethese lipoproteins lose A and acquire C and E apoproteins. VLDLcomprises A, B, C, and E apoproteins, LDL comprises apoprotein B; andHDL comprises apoproteins A, C, and E.

The amino acid of these apoproteins are known and are described in, forexample, Breslow (1985) Annu Rev. Biochem 54:699; Law (1986) Adv. ExpMed. Biol. 151:162; Chen (1986) J Biol Chem 261:12918; Kane (1980) ProcNatl Acad Sci USA 77:2465; and Utermann (1984) Hum Genet 65:232.

Lipoproteins contain a variety of lipids including, triglycerides,cholesterol (free and esters), and phopholipids. The composition of thelipids varies in naturally occurring lipoproteins. For example,chylomicrons comprise mainly triglycerides. A more detailed descriptionof the lipid content of naturally occurring lipoproteins can be found,for example, in Meth. Enzymol. 128 (1986). The composition of the lipidsare chosen to aid in conformation of the apoprotein for receptor bindingactivity. The composition of lipids can also be chosen to facilitatehydrophobic interaction and association with the polynucleotide bindingmolecule.

Naturally occurring lipoproteins can be isolated from serum byultracentrifugation, for instance. Such methods are described in Meth.Enzymol. (supra); Pitas (1980) J. Biochem. 255:5454-5460 and Mahey(1979) J Clin. Invest 64:743-750.

Lipoproteins can also be produced by in vitro or recombinant methods byexpression of the apoprotein genes in a desired host cell. See, forexample, Atkinson (1986) Annu Rev Biophys Chem 15:403 and Radding (1958)Biochim Biophys Acta 30: 443.

Lipoproteins can also be purchased from commercial suppliers, such asBiomedical Techniologies, Inc., Stoughton, Mass., USA.

Further description of lipoproteins can be found in Zuckermann et al.,PCT. Appin. No. US97/14465.

F. Polycationic Agents

Polycationic agents can be included, with or without lipoprotein, in acomposition with the desired polynucleotide or polypeptide to bedelivered.

Polycationic agents, typically, exhibit a net positive charge atphysiological relevant pH and are capable of neutralizing the electricalcharge of nucleic acids to facilitate delivery to a desired location.These agents have both in vitro, ex vivo, and in vivo applications.Polycationic agents can be used to deliver nucleic acids to a livingsubject either intramuscularly, subcutaneously, etc.

The following are examples of useful polypeptides as polycationicagents: polylysine, polyarginine, polyornithine, and protamine. Otherexamples include histones, protamines, human serum albumin, DNA bindingproteins, non-histone chromosomal proteins, coat proteins from DNAviruses, such as (X174, transcriptional factors also contain domainsthat bind DNA and therefore may be useful as nucleic aid condensingagents. Briefly, transcriptional factors such as C/CEBP, c-jun, c-fos,AP-1, AP-2, AP-3, CPF, Prot-1, Sp-1, Oct-1, Oct-2, CREP, and TFIIDcontain basic domains that bind DNA sequences.

Organic polycationic agents include: spermine, spermidine, andpurtrescine.

The dimensions and of the physical properties of a polycationic agentcan be extrapolated from the list above, to construct other polypeptidepolycationic agents or to produce synthetic polycationic agents.

Synthetic Polycationic Agents

Synthetic polycationic agents which are useful include, for example,DEAE-dextran, polybrene. LIPOFECTIN™, and LIPOFECTAMINE™ are monomersthat form polycationic complexes when combined with polynucleotides orpolypeptides.

Immunodiagnostic Assays

Neis serial antigens of the invention can be used in immunoassays todetect antibody levels (or, conversely, anti-Neisserial antibodies canbe used to detect antigen levels). Immunoassays based on well defined,recombinant antigens can be developed to replace invasive diagnosticsmethods. Antibodies to Neis serial proteins within biological samples,including for example, blood or serum samples, can be detected. Designof the immunoassays is subject to a great deal of variation, and avariety of these are known in the art. Protocols for the immunoassay maybe based, for example, upon competition, or direct reaction, or sandwichtype assays. Protocols may also, for example, use solid supports, or maybe by immunoprecipitation. Most assays involve the use of labeledantibody or polypeptide; the labels may be, for example, fluorescent,chemiluminescent, radioactive, or dye molecules. Assays which amplifythe signals from the probe are also known; examples of which are assayswhich utilize biotin and avidin, and enzyme-labeled and mediatedimmunoassays, such as ELISA assays.

Kits suitable for immunodiagnosis and containing the appropriate labeledreagents are constructed by packaging the appropriate materials,including the compositions of the invention, in suitable containers,along with the remaining reagents and materials (for example, suitablebuffers, salt solutions, etc.) required for the conduct of the assay, aswell as suitable set of assay instructions.

Nucleic Acid Hybridisation

“Hybridization” refers to the association of two nucleic acid sequencesto one another by hydrogen bonding. Typically, one sequence will befixed to a solid support and the other will be free in solution. Then,the two sequences will be placed in contact with one another underconditions that favor hydrogen bonding. Factors that affect this bondinginclude: the type and volume of solvent; reaction temperature; time ofhybridization; agitation; agents to block the non-specific attachment ofthe liquid phase sequence to the solid support (Denhardt's reagent orBLOTTO); concentration of the sequences; use of compounds to increasethe rate of association of sequences (dextran sulfate or polyethyleneglycol); and the stringency of the washing conditions followinghybridization. See Sambrook et al. [supra] Volume 2, chapter 9, pages9.47 to 9.57.

“Stringency” refers to conditions in a hybridization reaction that favorassociation of very similar sequences over sequences that differ. Forexample, the combination of temperature and salt concentration should bechosen that is approximately 120 to 200° C. below the calculated Tm ofthe hybrid under study. The temperature and salt conditions can often bedetermined empirically in preliminary experiments in which samples ofgenomic DNA immobilized on filters are hybridized to the sequence ofinterest and then washed under conditions of different stringencies. SeeSambrook et al. at page 9.50.

Variables to consider when performing, for example, a Southern blot are(1) the complexity of the DNA being blotted and (2) the homology betweenthe probe and the sequences being detected. The total amount of thefragment(s) to be studied can vary a magnitude of 10, from 0.1 to 1 μgfor a plasmid or phage digest to 10⁻⁹ to 10⁻⁸ g for a single copy genein a highly complex eukaryotic genome. For lower complexitypolynucleotides, substantially shorter blotting, hybridization, andexposure times, a smaller amount of starting polynucleotides, and lowerspecific activity of probes can be used. For example, a single-copyyeast gene can be detected with an exposure time of only 1 hour startingwith 1 μg of yeast DNA, blotting for two hours, and hybridizing for 4-8hours with a probe of 10⁸ cpm/μg. For a single-copy mammalian gene aconservative approach would start with 10 μg of DNA, blot overnight, andhybridize overnight in the presence of 10% dextran sulfate using a probeof greater than 10⁸ cpm/μg, resulting in an exposure time of −24 hours.

Several factors can affect the melting temperature (Tm) of a DNA-DNAhybrid between the probe and the fragment of interest, and consequently,the appropriate conditions for hybridization and washing. In many casesthe probe is not 100% homologous to the fragment. Other commonlyencountered variables include the length and total G+C content of thehybridizing sequences and the ionic strength and formamide content ofthe hybridization buffer. The effects of all of these factors can beapproximated by a single equation:

Tm=81+16.6(log₁₀ Ci)+0.4[%(G+C)]−0.6(% formamide)−600/n−1.5(% mismatch).

where Ci is the salt concentration (monovalent ions) and n is the lengthof the hybrid in base pairs (slightly modified from Meinkoth & Wahl(1984) Anal. Biochem. 138: 267-284).

In designing a hybridization experiment, some factors affecting nucleicacid hybridization can be conveniently altered. The temperature of thehybridization and washes and the salt concentration during the washesare the simplest to adjust. As the temperature of the hybridizationincreases (ie. stringency), it becomes less likely for hybridization tooccur between strands that are nonhomologous, and as a result,background decreases. If the radiolabeled probe is not completelyhomologous with the immobilized fragment (as is frequently the case ingene family and interspecies hybridization experiments), thehybridization temperature must be reduced, and background will increase.The temperature of the washes affects the intensity of the hybridizingband and the degree of background in a similar manner. The stringency ofthe washes is also increased with decreasing salt concentrations.

In general, convenient hybridization temperatures in the presence of 50%formamide are 42° C. for a probe with is 95% to 100% homologous to thetarget fragment, 37° C. for 90% to 95% homology, and 32° C. for 85% to90% homology. For lower homologies, formamide content should be loweredand temperature adjusted accordingly, using the equation above. If thehomology between the probe and the target fragment are not known, thesimplest approach is to start with both hybridization and washconditions which are nonstringent. If non-specific bands or highbackground are observed after autoradiography, the filter can be washedat high stringency and reexposed. If the time required for exposuremakes this approach impractical, several hybridization and/or washingstringencies should be tested in parallel.

Nucleic Acid Probe Assays

Methods such as PCR, branched DNA probe assays, or blotting techniquesutilizing nucleic acid probes according to the invention can determinethe presence of cDNA or mRNA. A probe is said to “hybridize” with asequence of the invention if it can form a duplex or double strandedcomplex, which is stable enough to be detected.

The nucleic acid probes will hybridize to the Neis serial nucleotidesequences of the invention (including both sense and antisense strands).Though many different nucleotide sequences will encode the amino acidsequence, the native Neis serial sequence is preferred because it is theactual sequence present in cells. mRNA represents a coding sequence andso a probe should be complementary to the coding sequence;single-stranded cDNA is complementary to mRNA, and so a cDNA probeshould be complementary to the non-coding sequence.

The probe sequence need not be identical to the Neisserial sequence (orits complement)—some variation in the sequence and length can lead toincreased assay sensitivity if the nucleic acid probe can form a duplexwith target nucleotides, which can be detected. Also, the nucleic acidprobe can include additional nucleotides to stabilize the formed duplex.Additional Neisserial sequence may also be helpful as a label to detectthe formed duplex. For example, a non-complementary nucleotide sequencemay be attached to the 5′ end of the probe, with the remainder of theprobe sequence being complementary to a Neisserial sequence.Alternatively, non-complementary bases or longer sequences can beinterspersed into the probe, provided that the probe sequence hassufficient complementarity with the a Neis serial sequence in order tohybridize therewith and thereby form a duplex which can be detected.

The exact length and sequence of the probe will depend on thehybridization conditions, such as temperature, salt condition and thelike. For example, for diagnostic applications, depending on thecomplexity of the analyte sequence, the nucleic acid probe typicallycontains at least 10-20 nucleotides, preferably 15-25, and morepreferably at least 30 nucleotides, although it may be shorter thanthis. Short primers generally require cooler temperatures to formsufficiently stable hybrid complexes with the template.

Probes may be produced by synthetic procedures, such as the triestermethod of Matteucci et al. [J. Am. Chem. Soc. (1981) 103:3185], oraccording to Urdea et al. [Proc. Natl. Acad. Sci. USA (1983) 80: 7461],or using commercially available automated oligonucleotide synthesizers.

The chemical nature of the probe can be selected according topreference. For certain applications, DNA or RNA are appropriate. Forother applications, modifications may be incorporated eg. backbonemodifications, such as phosphorothioates or methylphosphonates, can beused to increase in vivo half-life, alter RNA affinity, increasenuclease resistance etc. [eg. see Agrawal & Iyer (1995) Curr OpinBiotechnol 6:12-19; Agrawal (1996) TIBTECH 14:376-387]; analogues suchas peptide nucleic acids may also be used [eg. see Corey (1997) TIBTECH15:224-229; Buchardt et al. (1993) TIBTECH 11:384-386].

One example of a nucleotide hybridization assay is described by Urdea etal. in international patent application WO92/02526 [see also U.S. Pat.No. 5,124,246].

Alternatively, the polymerase chain reaction (PCR) is another well-knownmeans for detecting small amounts of target nucleic acids. The assay isdescribed in: Mullis et al. [Meth. Enzymol. (1987) 155: 335-350]; U.S.Pat. No. 4,683,195; and U.S. Pat. No. 4,683,202. Two “primer”nucleotides hybridize with the target nucleic acids and are used toprime the reaction. The primers can comprise sequence that does nothybridize to the sequence of the amplification target (or itscomplement) to aid with duplex stability or, for example, to incorporatea convenient restriction site. Typically, such sequence will flank thedesired Neisserial sequence.

A thermostable polymerase creates copies of target nucleic acids fromthe primers using the original target nucleic acids as a template. Aftera threshold amount of target nucleic acids are generated by thepolymerase, they can be detected by more traditional methods, such asSouthern blots. When using the Southern blot method, the labelled probewill hybridize to the Neisserial sequence (or its complement).

Also, mRNA or cDNA can be detected by traditional blotting techniquesdescribed in Sambrook et al [supra]. mRNA, or cDNA generated from mRNAusing a polymerase enzyme, can be purified and separated using gelelectrophoresis. The nucleic acids on the gel are then blotted onto asolid support, such as nitrocellulose. The solid support is exposed to alabelled probe and then washed to remove any unhybridized probe. Next,the duplexes containing the labeled probe are detected. Typically, theprobe is labelled with a radioactive moiety.

EXAMPLES

The examples describe nucleic acid sequences which have been identifiedin N. meningitidis, and N. gonorrhoeae along with their respective andputative translation products. Not all of the nucleic acid sequences arecomplete ie. they encode less than the full-length wild-type protein.

The examples are generally in the following format:

-   -   a nucleotide sequence which has been identified in N.        meningitidis    -   the putative translation product of said N. meningitidis        sequence    -   a computer analysis of said translation product based on        database comparisons    -   a corresponding nucleotide sequence identified from N.        gonorrhoeae    -   the putative translation product of said N. gonorrhoeae sequence    -   a comparision of the percentage of identity between the        translation product of the N. meningitidis sequence and the N.        gonorrhoeae sequence    -   a description of the characteristics of the protein which        indicates that it might be suitably antigenic or immunogenic.

Sequence comparisons were performed at NCBI (ncbi.nlm.nih.gov) using thealgorithms BLAST, BLAST2, BLASTn, BLASTp, tBLASTn, BLASTx, & tBLASTx[eg. see also Altschul et al. (1997) Gapped BLAST and PSI-BLAST: a newgeneration of protein database search programs. Nucleic Acids Research25:2289-3402]. Searches were performed against the following databases:non-redundant GenBank+EMBL+DDBJ+PDB sequences and non-redundant GenBankCDS translations+PDB+SwissProt+SPupdate+PIR sequences.

Dots within nucleotide sequences represent nucleotides which have beenarbitrarily introduced in order to maintain a reading frame. In the sameway, double-underlined nucleotides were removed. Lower case lettersrepresent ambiguities which arose during alignment of independentsequencing reactions (some of the nucleotide sequences in the examplesare derived from combining the results of two or more experiments).

Nucleotide sequences were scanned in all six reading frames to predictthe presence of hydrophobic domains using an algorithm based on thestatistical studies of Esposti et al. [Critical evaluation of thehydropathy of membrane proteins (1990) Eur J Biochem 190:207-219]. Thesedomains represent potential transmembrane regions or hydrophobic leadersequences.

Open reading frames were predicted from fragmented nucleotide sequencesusing the program ORFFINDER (NCBI).

Underlined amino acid sequences indicate possible transmembrane domainsor leader sequences in the ORFs, as predicted by the PSORT algorithm(psort.nibb.ac.jp). Functional domains were also predicted using theMOTIFS program (GCG Wisconsin & PROSITE).

For each of the following examples: based on the presence of a putativeleader sequence and/or several putative transmembrane domains(single-underlined) in the gonococcal protein, it is predicted that theproteins from N. meningitidis and N. gonorrhoeae, and their respectiveepitopes, could be useful antigens or immunogenic compositions forvaccines or diagnostics.

The standard techniques and procedures which may be employed in order toperform the invention (e.g. to utilize the disclosed sequences forvaccination or diagnostic purposes) were summarized above. This summaryis not a limitation on the invention but, rather, gives examples thatmay be used, but are not required.

In particular, the following methods were used to express, purify andbiochemically characterize the proteins of the invention.

Chromosomal DNA Preparation

N. meningitidis strain 2996 was grown to exponential phase in 100 ml ofGC medium, harvested by centrifugation, and resuspended in 5 ml buffer(20% Sucrose, 50 mM Tris-HCl, 50 mM EDTA, pH 8.0). After 10 minutesincubation on ice, the bacteria were lysed by adding 10 ml lysissolution (50 mM NaCl, 1% Na-SARKOSYL™, 50 μg/ml Proteinase K), and thesuspension was incubated at 37° C. for 2 hours. Two phenol extractions(equilibrated to pH 8) and one CHCl₃/isoamylalcohol (24:1) extractionwere performed. DNA was precipitated by addition of 0.3M sodium acetateand 2 volumes ethanol, and was collected by centrifugation. The pelletwas washed once with 70% ethanol and redissolved in 4.0 ml TE buffer (10mM Tris-HCl, 1 mM EDTA, pH 8). The DNA concentration was measured byreading the OD at 260 nm.

Oligonucleotide Design

Synthetic oligonucleotide primers were designed on the basis of thecoding sequence of each ORF, using (a) the meningococcus B sequence whenavailable, or (b) the gonococcus/meningococcus A sequence, adapted tothe codon preference usage of meningococcus as necessary. Any predictedsignal peptides were omitted, by designing the 5′ primers to sequenceimmediately downstream from the predicted leader sequence.

For most ORFs, the 5′ primers included two restriction enzymerecognition sites (BamHI-NdeI, BamHI-NheI, EcoRI-NdeI or EcoRI-NheI),depending on the restriction pattern of the gene of interest. The 3′primers included a XhoI or a HindIII restriction site (table 1). Thisprocedure was established in order to direct the cloning of eachamplification product (corresponding to each ORF) into two differentexpression systems: pGEX-KG (using either BamHI-XhoI, BamHI-HindIII,EcoRI-XhoI, or EcoRI-HindIII), and pET21b+(using either NdeI-XhoI,NheI-XhoI, NdeI-HindIII, or NheI-HindIII).

5′-end primer tail: CGCGGATCCCATATG (BamHI-NdeI) CGCGGATCCGCTAGC(BamHI-NheI) CCGGAATTCTAGATATC (EcoRI-NdeI) CCGGAATTCTAGCTAGC(EcoRI-NheI) 3′-end primer tail: CCCGCTCGAG (XhoI) CCCGCTCGAG (HindIII)

For cloning ORFs into the pGEX-His Vector, the 5′ and 3′ primerscontained only one restriction enzyme site (EcoRI, KpnI or SalI for the5′ primers and PstI, XbaI, SphI or SalI for the 3′ primers). Againrestriction sites were chosen according to the particular restrictionpattern of the gene (table 1).

5′-end primer tail: (AAA)AAAGAATTC (EcoRI) (AAA)AAAGGATCC (KpnI) 3′-endprimer tail: (AAA)AAACTGCAG (PstI) (AAA)AAATCTAGA (XbaI) AAAGCATGC(SphI) 5′ or 3′-end primer tail: AAAAAAGAATCC (PstI)

As well as containing the restriction enzyme recognition sequences, theprimers included nucleotides which hybridized to the sequence to beamplified. The melting temperature depended on the number and type ofhybridizing nucleotides in the whole primer, and was determined for eachprimer using the formulae:

T _(m)=4(G+C)+2(A+T)  (tail excluded)

T _(m)=64.9+0.41(% GC)−600/N  (whole primer)

The melting temperature of the selected oligonucleotides were usually65-70° C. for the whole oligo and 50-55° C. for the hybridising regionalone.

Table 1 shows the forward and reverse primers used for eachamplification. In certain cases, the sequences of the primer does notmatch exactly the sequence of the predicted ORF. This is because wheninitial amplifications were performed, the complete 5′ and/or 3′sequences for some meningococcal B ORFs were not be known. However, thecorresponding sequences had been identified in Gonococcus or inMeningococcus A. Hence, when the Meningococcus B sequence was incompleteor uncertain, Gonococcus or in Meningococcus A sequences were used asthe basis for the primer design. These sequences were altered to takeaccount of codon preference. It can be appreciated that, once thecomplete sequence is identified, this approach will no longer benecessary.

Oligonucleotides were synthesized using a Perkin Elmer 394 DNA/RNASYNTHESIZER™, eluted from the columns in 2.0 ml NH₄OH, and deprotectedby 5 hours incubation at 56° C. The oligos were precipitated by additionof 0.3M Na-Acetate and 2 volumes ethanol. The samples were centrifugedand the pellets resuspended in either 100 μl or 1.0 ml of water. TheOD₂₆₀ was determined using a Perkin Elmer LAMBDA BIO™ spectophotometerand the concentration adjusted to 2-10 pmol/μl.

Amplification

The standard PCR protocol was as follows: 50-200 ng of genomic DNA wasused as a template in the presence of 20-40 μM of each oligonucleotideprimer, 400-800 μM dNTPs solution, 1×PCR buffer (including 1.5 mMMgCl₂), 2.5 units TaqI DNA polymerase (using Perkin-Elmer AMPLITAQ™,GIBCO Platinum, Pwo DNA polymerase, or Tahara Shuzo Taq polymerase). Insome cases, PCR was optimised by the addition of 10 μl of DMSO or 50 μlof 2M Betaine.

After a hot start (adding the polymerase during a preliminary 3 minuteincubation of the whole mix at 95° C.), each sample underwent a two-stepamplification. The first 5 cycles were performed using the hybridizationtemperature that excluded the restriction enzyme tail of the primer (seeabove). This was followed by 30 cycles using the hybridizationtemperature calculated for the whole length oligos. The cycles werefollowed by a final 10 minute extension step at 72° C. The standardcycles were as follows:

Denaturation Hybridisation Elongation First 5 cycles 30 seconds 30seconds 30-60 seconds 95° C. 50-55° C. 72° C. Last 30 cycles 30 seconds30 seconds 30-60 seconds 95° C. 65-70° C. 72° C.

The elongation time varied according to the length of the ORF to beamplified. Amplifications were performed using either a 9600 or a 2400Perkin Elmer GeneAmp PCR System. To check the results, 1/10 of theamplification volume was loaded onto a 1-1.5% (w/v) agarose gel and thesize of each amplified fragment compared with a DNA molecular weightmarker.

The amplified DNA was either loaded directly on a 1% agarose gel orfirst precipitated with ethanol and resuspended in a volume suitable tobe loaded on a 1.0% agarose gel. The DNA fragment corresponding to theband of the correct size was purified using the Qiagen Gel ExtractionKit, following the manufacturer's protocol. DNA fragments were eluted ina volume of 30 μl or 50 μl of either H2O or 10 mM Tris, pH 8.5.

Digestion of PCR Fragments

The purified DNA corresponding to the amplified fragment wasdouble-digested with the appropriate restriction enzymes for; cloninginto pET-21b+ and expressing the protein as a C-terminus His-taggedfusion, for cloning into pGEX-KG and expressing the protein as aN-terminus GST-fusion, and for cloning into pGEX-His and expressing theprotein as a N-terminus GST-his tagged fusion.

Each purified DNA fragment was incubated at 37° C. for 3 hours toovernight with 20 units of appropriate restriction enzyme (New EnglandBiolabs) in a either 30 or 40 μl in the presence of suitable digestionbuffer. Digested products were purified using the QIAquick PCRpurification kit (following the manufacturer's instructions) and elutedin a final volume of 30 or 50 μl of either H2O or 10 mM Tris, pH 8.5.The DNA concentration was determined by quantitative agarose gelelectrophoresis (1.0% gel) in the presence of a titrated molecularweight marker.

Digestion of the Cloning Vectors (pET22B, pGEX-KG, pTRC-his A, pET21b+,pGEX-KG, and pGEX-His)

The vector pGEX-His is a modified pGEX-2T vector carrying a regionencoding six histidine residues upstream of the thrombin cleavage siteand containing the multiple cloning site of the vector pTRC99(Pharmacia). 10 μg plasmid was double-digested with 50 units of eachrestriction enzyme in 200 μl reaction volume in the presence ofappropriate buffer by overnight incubation at 37° C. After loading thewhole digestion on a 1% agarose gel, the band corresponding to thedigested vector was purified from the gel using the Qiagen QIAquick GelExtraction Kit and the DNA was eluted in 50 μl of 10 mM Tris-HCl, pH8.5. The DNA concentration was evaluated by measuring OD₂₆₀ of thesample, and adjusted to 50 μg/μl 1 μl of plasmid was used for eachcloning procedure.

10 μg plasmid was double-digested with 50 units of each restrictionenzyme in 200 μl reaction volume in the presence of appropriate bufferby overnight incubation at 37° C. The digest was loaded onto a 1%agarose gel and the band corresponding to the digested vector purifiedusing the Qiagen QIAquick Gel Extraction Kit. DNA was eluted in 50 μl of10 mM Tris-HCl, pH 8.5. The DNA concentration was evaluated by measuringOD₂₆₀ and the concentration adjusted to 50 μg/μl. 1 μl of plasmid wasused for each cloning procedure.

Cloning

For some ORFs, the fragments corresponding to each ORF, previouslydigested and purified, were ligated in both pET22b and pGEX-KG. In afinal volume of 20 μl, a molar ratio of 3:1 fragment/vector was ligatedusing 0.5 μl of NEB T4 DNA ligase (400 units/μl), in the presence of thebuffer supplied by the manufacturer. The reaction was incubated at roomtemperature for 3 hours. In some experiments, ligation was performedusing the Boheringer “Rapid Ligation Kit”, following the manufacturer'sinstructions.

In order to introduce the recombinant plasmid in a suitable strain, 100μl E. coli DH5 competent cells were incubated with the ligase reactionsolution for 40 minutes on ice, then at 37° C. for 3 minutes, then,after adding 800 μl LB broth, again at 37° C. for 20 minutes. The cellswere then centrifuged at maximum speed in an Eppendorf microfuge andresuspended in approximately 200 μl of the supernatant. The suspensionwas then plated on LB ampicillin (100 mg/ml).

The screening of the recombinant clones was performed by growing 5randomly-chosen colonies overnight at 37° C. in either 2 ml (pGEX or pTCclones) or 5 ml (pET clones) LB broth+100 μg/ml ampicillin. The cellswere then pelletted and the DNA extracted using the Qiagen QIAprep SpinMiniprep Kit, following the manufacturer's instructions, to a finalvolume of 30 μl. 5 μl of each individual miniprep (approximately 1 g)were digested with either NdeI/XhoI or BamHI/XhoI and the wholedigestion loaded onto a 1-1.5% agarose gel (depending on the expectedinsert size), in parallel with the molecular weight marker (1Kb DNALadder, GIBCO). The screening of the positive clones was made on thebase of the correct insert size.

For other ORFs, the fragments corresponding to each ORF, previouslydigested and purified, were ligated in both pET21b+ and pGEX-KG. A molarratio of 3:1 fragment/vector was used in a final volume of 20 μl, thatincluded 0.5 μl of T4 DNA ligase (400 units/μl, NEB) and ligation buffersupplied by the manufacturer. The reaction was performed at roomtemperature for 3 hours. In some experiments, ligation was performedusing the Boheringer “Rapid Ligation Kit” and the manufacturer'sprotocol.

Recombinant plasmid was transformed into 100 μl of competent E. coli DH5or HB101 by incubating the ligase reaction solution and bacteria for 40minutes on ice then at 37° C. for 3 minutes. This was followed byaddition of 800 μl LB broth and incubation at 37° C. for 20 minutes. Thecells were then centrifuged at maximum speed in an Eppendorf microfuge,resuspended in approximately 200 μl of the supernatant, and plated on LBampicillin (100 mg/ml) agar.

Screening for recombinant clones was performed by growing 5 randomlyselected colonies overnight at 37° C. in either 2.0 ml (pGEX-KG clones)or 5.0 ml (pET clones) LB broth+100 μg/ml ampicillin. Cells werepelleted and plasmid DNA extracted using the Qiagen QIAprep SpinMiniprep Kit, following the manufacturer's instructions. Approximately 1μg of each individual miniprep was digested with the appropriaterestriction enzymes and the digest loaded onto a 1-1.5% agarose gel(depending on the expected insert size), in parallel with the molecularweight marker (1 kb DNA Ladder, GIBCO). Positive clones were selected onthe basis of the size of the insert.

ORFs were cloned in PGEX-His, by doubly-digesting the PC product andligating into similarly digested vector. After cloning, recombinantplasmids were transformed into the E. coli host W3110. Individual cloneswere grown overnight at 37° C. in LB broth with 50 μg/ml ampicillin.

Certain ORFs may be cloned into the pGEX-HIS vector using EcoRI-PstIcloning sites, or EcoRI-SalI, or SalI-PstI. After cloning, therecombinant plasmids may be introduced in the E. coli host W3110.

Expression

Each ORF cloned into the expression vector may then be transformed intothe strain suitable for expression of the recombinant protein product. 1μl of each construct was used to transform 30 μl of E. coli BL21 (pGEXvector), E. coli TOP 10 (pTRC vector) or E. coli BL21-DE3 (pET vector),as described above. In the case of the pGEX-His vector, the same E. colistrain (W3110) was used for initial cloning and expression. Singlerecombinant colonies were inoculated into 2 ml LB+Amp (100 μg/ml),incubated at 37° C. overnight, then diluted 1:30 in 20 ml of LB+Amp (100vs/nal) in 100 ml flasks, making sure that the OD₆₀₀ ranged between 0.1and 0.15. The flasks were incubated at 30° C. into gyratory water bathshakers until OD indicated exponential growth suitable for induction ofexpression (0.4-0.8 OD for pET and pTRC vectors; 0.8-1 OD for pGEX andpGEX-His vectors). For the pET, pTRC and pGEX-His vectors, the proteinexpression was induced by addiction of 1 mM IPTG, whereas in the case ofpGEX system the final concentration of IPTG was 0.2 mM. After 3 hoursincubation at 30° C., the final concentration of the sample was checkedby OD. In order to check expression, 1 ml of each sample was removed,centrifuged in a microfuge, the pellet resuspended in PBS, and analysedby 12% SDS-PAGE with Coomassie Blue staining. The whole sample wascentrifuged at 6000 g and the pellet resuspended in PBS for further use.

GST-Fusion Proteins Large-Scale Purification.

For some ORFs, a single colony was grown overnight at 37° C. on LB+Ampagar plate. The bacteria were inoculated into 20 ml of LB+Amp liquidculture in a water bath shaker and grown overnight. Bacteria werediluted 1:30 into 600 ml of fresh medium and allowed to grow at theoptimal temperature (20-37° C.) to OD₅₅₀ 0.8-1. Protein expression wasinduced with 0.2 mM IPTG followed by three hours incubation. The culturewas centrifuged at 8000 rpm at 4° C. The supernatant was discarded andthe bacterial pellet was resuspended in 7.5 ml cold PBS. The cells weredisrupted by sonication on ice for 30 sec at 40 W using a Bransonsonifier B-15, frozen and thawed two times and centrifuged again. Thesupernatant was collected and mixed with 150 μl GLUTATHIONE-SEPHAROSE4B™ resin (Pharmacia) (previously washed with PBS) and incubated at roomtemperature for 30 minutes. The sample was centrifuged at 700 g for 5minutes at 4C. The resin was washed twice with 10 ml cold PBS for 10minutes, resuspended in 1 ml cold PBS, and loaded on a disposablecolumn. The resin was washed twice with 2 ml cold PBS until theflow-through reached OD₂₈₀ of 0.02-0.06. The GST-fusion protein waseluted by addition of 700 μl cold Glutathione elution buffer (10 mMreduced glutathione, 50 mM Tris-HCl) and fractions collected until theOD₂₈₀ was 0.1. 21 μl of each fraction were loaded on a 12% SDS gel usingeither Biorad SDS-PAGE Molecular weight standard broad range (M1) (200,116.25, 97.4, 66.2, 45, 31, 21.5, 14.4, 6.5 kDa) or Amersham RainbowMarker (M″) (220, 66, 46, 30, 21.5, 14.3 kDa) as standards. As the MW ofGST is 26 kDa, this value must be added to the MW of each GST-fusionprotein.

For other ORFs, for each clone to be purified as a GST-fusion, a singlecolony was streaked out and grown overnight at 37° C. on LB/Amp (100μg/ml) agar plate. An isolated colony from this plate was inoculatedinto 20 ml of LB/Amp (100 μg/ml) liquid medium and grown overnight at37° C. with shaking. The overnight culture was diluted 1:30 into 600 mlof LB/Amp (100 μg/ml) liquid medium and allowed to grow at the optimaltemperature (20-37° C.) until the OD₅₅₀ reached 0.6-0.8. Recombinantprotein expression was induced by addition of IPTG (final concentration0.2 mM) and the culture incubated for a further 3 hours. The bacteriawere harvested by centrifugation at 8000×g for 15 min at 4° C.

The bacterial pellet was resuspended in 7.5 ml cold PBS. Cells weredisrupted by sonication on ice for 30 sec at 40 W using a Bransonsonifier 450 and centrifuged at 13 000×g for 30 min at 4° C. Thesupernatant was collected and mixed with 150 μl GLUTATHIONE-SEPHAROSE4B™ resin (Pharmacia), previously equilibrated with PBS, and incubatedat room temperature with gentle agitation for 30 min. The batch-wisepreparation was centrifuged at 700×g for 5 min at 4° C. and thesupernatant discarded. The resin was washed twice (batchwise) with 10 mlcold PBS for 10 min, resuspended in 1 ml cold PBS, and loaded onto adisposable column. The resin continued to be washed twice with cold PBS,until the OD_(280nm) of the flow-through reached 0.02-0.01. TheGST-fusion protein was eluted by addition of 700 μl cold glutathioneelution buffer (10 mM reduced glutathione, 50 mM Tris-HCl pH 8.0) andfractions collected, until the OD_(280nm) of the eluate indicated allthe recombinant protein was obtained. 20 μl aliquots of each elutionfraction were analyzed by SDS-PAGE using a 12% gel. The molecular massof the purified proteins was determined using either the Bio-Rad broadrange molecular weight standard (M1) (200, 116, 97.4, 66.2, 45.0, 31.0,21.5, 14.4, 6.5 kDa) or the Amersham Rainbow Marker (M2) (220, 66.2,46.0, 30.0, 21.5, 14.3 kDa). The molecular weights of GST-fusionproteins are a combination of the 26 kDa GST protein and its fusionpartner. Protein concentrations were estimated using the Bradford assay.

His-Fusion Soluble Proteins Large-Scale Purification.

For some ORFs, a single colony was grown overnight at 37° C. on a LB+Ampagar plate. The bacteria were inoculated into 20 ml of LB+Amp liquidculture and incubated overnight in a water bath shaker. Bacteria werediluted 1:30 into 600 ml fresh medium and allowed to grow at the optimaltemperature (20-37° C.) to OD₅₅₀ 0.6-0.8. Protein expression was inducedby addition of 1 mM IPTG and the culture further incubated for threehours. The culture was centrifuged at 8000 rpm at 4° C., the supernatantwas discarded and the bacterial pellet was resuspended in 7.5 ml cold 10mM imidazole buffer (300 mM NaCl, 50 mM phosphate buffer, 10 mMimidazole, pH 8). The cells were disrupted by sonication on ice for 30sec at 40 W using a Branson sonifier B-15, frozen and thawed two timesand centrifuged again. The supernatant was collected and mixed with 150μNi²⁺-resin (Pharmacia) (previously washed with 10 mM imidazole buffer)and incubated at room temperature with gentle agitation for 30 minutes.The sample was centrifuged at 700 g for 5 minutes at 4° C. The resin waswashed twice with 10 ml cold 10 mM imidazole buffer for 10 minutes,resuspended in 1 ml cold 10 mM imidazole buffer and loaded on adisposable column. The resin was washed at 4° C. with 2 ml cold 10 mMimidazole buffer until the flow-through reached the O.D₂₈₀ of 0.02-0.06.The resin was washed with 2 ml cold 20 mM imidazole buffer (300 mM NaCl,50 mM phosphate buffer, 20 mM imidazole, pH 8) until the flow-throughreached the O.D₂₈₀ of 0.02-0.06. The His-fusion protein was eluted byaddition of 700 μl cold 250 mM imidazole buffer (300 mM NaCl, 50 mMphosphate buffer, 250 mM imidazole, pH 8) and fractions collected untilthe O.D₂₈₀ was 0.1. 21 μl of each fraction were loaded on a 12% SDS gel.

His-Fusion Insoluble Proteins Large-Scale Purification.

A single colony was grown overnight at 37° C. on a LB+Amp agar plate.The bacteria were inoculated into 20 ml of LB+Amp liquid culture in awater bath shaker and grown overnight. Bacteria were diluted 1:30 into600 ml fresh medium and let to grow at the optimal temperature (37° C.)to O.D₅₅₀ 0.6-0.8. Protein expression was induced by addition of 1 mMIPTG and the culture further incubated for three hours. The culture wascentrifuged at 8000 rpm at 4° C. The supernatant was discarded and thebacterial pellet was resuspended in 7.5 ml buffer B (urea 8M, 10 mMTris-HCl, 100 mM phosphate buffer, pH 8.8). The cells were disrupted bysonication on ice for 30 sec at 40 W using a Branson sonifier B-15,frozen and thawed twice and centrifuged again. The supernatant wasstored at −20° C., while the pellets were resuspended in 2 ml guanidinebuffer (6M guanidine hydrochloride, 100 mM phosphate buffer, 10 mMTris-HCl, pH 7.5) and treated in a homogenizer for 10 cycles. Theproduct was centrifuged at 13000 rpm for 40 minutes. The supernatant wasmixed with 150 μl Ni²⁺-resin (Pharmacia) (previously washed with bufferB) and incubated at room temperature with gentle agitation for 30minutes. The sample was centrifuged at 700 g for 5 minutes at 4° C. Theresin was washed twice with 10 ml buffer B for 10 minutes, resuspendedin 1 ml buffer B, and loaded on a disposable column. The resin waswashed at room temperature with 2 ml buffer B until the flow-throughreached the OD₂₈₀ of 0.02-0.06. The resin was washed with 2 ml buffer C(urea 8M, 10 mM Tris-HCl, 100 mM phosphate buffer, pH 6.3) until theflow-through reached the O.D₂₈₀ of 0.02-0.06. The His-fusion protein waseluted by addition of 700 g elution buffer (urea 8M, 10 mM Tris-HCl, 100mM phosphate buffer, pH 4.5) and fractions collected until the OD₂₈₀ was0.1. 21 μl of each fraction were loaded on a 12% SDS gel.

Purification of His-Fusion Proteins.

For each clone to be purified as a His-fusion, a single colony wasstreaked out and grown overnight at 37° C. on LB/Amp (100 μg/ml) agarplate. An isolated colony from this plate was inoculated into 20 ml ofLB/Amp (100 μg/ml) liquid medium and grown overnight at 37° C. withshaking. The overnight culture was diluted 1:30 into 600 ml of LB/Amp(100 μg/ml) liquid medium and allowed to grow at the optimal temperature(20-37° C.) until the OD₅₅₀ reached 0.6-0.8. Expression of recombinantprotein was induced by addition of IPTG (final concentration 1.0 mM) andthe culture incubated for a further 3 hours. The bacteria were harvestedby centrifugation at 8000×g for 15 min at 4° C.

The bacterial pellet was resuspended in 7.5 ml either (i) cold buffer A(300 mM NaCl, 50 mM phosphate buffer, 10 mM imidazole, pH 8.0) forsoluble proteins or (ii) buffer B (8M urea, 10 mM TrisHCl, 100 mMphosphate buffer, pH 8.8) for insoluble proteins. Cells were disruptedby sonication on ice four times for 30 sec at 40 W using a Bransonsonifier 450 and centrifuged at 13 000×g for 30 min at 4° C. Forinsoluble proteins, pellets were resuspended in 2.0 ml buffer C (6Mguanidine hydrochloride, 100 mM phosphate buffer, 10 mM Tris-HCl, pH7.5) and treated with a Dounce homogenizer for 10 cycles. The homogenatewas centrifuged at 13 000×g for 40 min and the supernatant retained.

Supernatants for both soluble and insoluble preparations were mixed with150 μl Ni²⁺-resin (previously equilibrated with either buffer A orbuffer B, as appropriate) and incubated at room temperature with gentleagitation for 30 min. The resin was CHELATING SEPHAROSE FAST FLOW™(Pharmacia), prepared according to the manufacturers protocol. Thebatch-wise preparation was centrifuged at 700×g for 5 min at 4° C. andthe supernatant discarded. The resin was washed twice (batch-wise) with10 ml buffer A or B for 10 min, resuspended in 1.0 ml buffer A or B andloaded onto a disposable column. The resin continued to be washed witheither (i) buffer A at 4° C. or (ii) buffer B at room temperature, theOD_(280nm) of the flow-through reached 0.02-0.01. The resin was furtherwashed with either (i) cold buffer C (300 mM NaCl, 50 mM phosphatebuffer, 20 mM imidazole, pH 8.0) or (ii) buffer D (8M urea, 10 mMTris-HCl, 100 mM phosphate buffer, pH 6.3) until the OD_(280nm) of theflow-through reached 0.02-0.01. The His-fusion protein was eluted byaddition of 700 μl of either (1) cold elution buffer A (300 mM NaCl, 50mM phosphate buffer, 250 mM imidazole, pH 8.0) or (ii) elution buffer B(8 M urea, 10 mM Tris-HCl, 100 mM phosphate buffer, pH 4.5) andfractions collected until the O.D_(280nm) indicated all the recombinantprotein was obtained. 20 μl aliquots of each elution fraction wereanalyzed by SDS-PAGE using a 12% gel. Protein concentrations wereestimated using the Bradford assay.

His-Fusion Proteins Renaturation

In the cases where denaturation was required to solubilize proteins, arenaturation step was employed prior to immunization. Glycerol was addedto the denatured fractions obtained above to a final concentration of10%(v/v). The proteins were then diluted to 200 m/ml using dialysisbuffer I (10%(v/v) glycerol, 0.5M arginine, 50 mM phosphate buffer, 5 mMreduced glutathione, 0.5 mM oxidised glutathione, 2M urea, pH 8.8) anddialysed against the same buffer for 12-14 hours at 4° C. Furtherdialysis was performed with buffer II (10% (v/v) glycerol, 0.5Marginine, 50 mM phosphate buffer, 50 mM reduced glutathione, 5.0 mMoxidised glutathione, pH 8.8) for 12-14 hours at 4° C.

Alternatively, 10% glycerol was added to the denatured proteins. Theproteins were then diluted to 20 m/ml using dialysis buffer I (10%glycerol, 0.5M arginine, 50 mM phosphate buffer, 5 mM reducedglutathione, 0.5 mM oxidised glutathione, 2M urea, pH 8.8) and dialysedagainst the same buffer at 4° C. for 12-14 hours. The protein wasfurther dialysed against dialysis buffer II (10% glycerol, 0.5Marginine, 50 mM phosphate buffer, 5 mM reduced glutathione, 0.5 mMoxidised glutathione, pH 8.8) for 12-14 hours at 4° C.

Protein concentration was evaluated using the formula:

Protein (mg/ml)=(1.55×OD ₂₈₀)−(0.76×OD ₂₆₀)

Purification of Proteins

To analyse the solubility, pellets obtained from 3.0 ml cultures wereresuspended in 500 μl buffer M1 (PBS pH 7.2). 25 μl of lysozyme (10mg/ml) was added and the bacteria incubated for 15 min at 4° C. Cellswere disrupted by sonication on ice four times for 30 sec at 40 W usinga Branson sonifier 450 and centrifuged at 13 000×g for 30 min at 4° C.The supernatant was collected and the pellet resuspended in buffer M2[8M urea, 0.5M NaCl, 20 mM imidazole and 0.1 M NaH₂PO₄] and incubatedfor 3 to 4 hours at 4° C. After centrifugation, the supernatant wascollected and the pellet resuspended in buffer M3 [6M guanidinium-HCl,0.5M NaCl, 20 mM imidazole and 0.1 M NaH₂PO₄] overnight at 4° C. Thesupernatants from all steps were analysed by SDS-PAGE. Some proteinswere found to be soluble in PBS, others needed urea or guanidinium-HClfor solubilization.

For preparative scale purification, 500 ml cultures were induced andfusion proteins solubilized in either buffer M1, M2, or M3 using theprocedure described above. Crude extracts were loaded onto a Ni-NTAsuperflow column (Qiagen) equilibrated with buffer M1, M2, or M3depending on the solubilization buffer employed. Unbound material waseluted with the corresponding buffer containing 500 mM imidazole thendialysed against the same buffer in the absence of imidazole.

Mice Immunisations

20 μg of each purified protein are used to immunise miceintraperitoneally. In the case of some ORFs, Balb-C mice were immunisedwith Al(OH)₃ as adjuvant on days 1, 21 and 42, and immune response wasmonitored in samples taken on day 56. For other ORFs, CD1 mice could beimmunised using the same protocol. For ORFs 25 and 40, CD1 mice wereimmunised using Freund's adjuvant, and the same immunisation protocolwas used, except that the immune response was measured on day 42, ratherthan 56. Similarly, for still other ORFs, CD1 mice were immunised withFreund's adjuvant, but the immune response was measured on day 49.Alternatively, 20 μg of each purified protein was mixed with Freund'sadjuvant and used to immunize CD1 mice intraperitoneally. For many ofthe proteins, the immunization was performed on days 1, 21 and 35, andimmune response was monitored in samples taken on days 34 and 49. Forsome proteins, the third immunization was performed on day 28, ratherthan 35, and immune response was measured on days 20 and 42, rather than34 and 49.

ELISA Assay (Sera Analysis)

The acapsulated MenB M7 strain was plated on chocolate agar plates andincubated overnight at 37° C. Bacterial colonies were collected from theagar plates using a sterile dracon swab and inoculated into 7 ml ofMueller-Hinton Broth (Difco) containing 0.25% Glucose. Bacterial growthwas monitored every 30 minutes by following OD₆₂₀. The bacteria were letto grow until the OD reached the value of 0.3-0.4. The culture wascentrifuged for 10 minutes at 10000 rpm. The supernatant was discardedand bacteria were washed once with PBS, resuspended in PBS containing0.025% formaldehyde, and incubated for 2 hours at room temperature andthen overnight at 4° C. with stirring. 100 μl bacterial cells were addedto each well of a 96 well Greiner plate and incubated overnight at 4° C.The wells were then washed three times with PBT washing buffer (0.1%TWEEN-20™ in PBS). 200 μl of saturation buffer (2.7%Polyvinylpyrrolidone 10 in water) was added to each well and the platesincubated for 2 hours at 37° C. Wells were washed three times with PBT.200 μl of diluted sera (Dilution buffer: 1% BSA, 0.1% TWEEN-20™, 0.1%NaN₃ in PBS) were added to each well and the plates incubated for 90minutes at 37° C. Wells were washed three times with PBT. 100 μl ofHRP-conjugated rabbit anti-mouse (Dako) serum diluted 1:2000 in dilutionbuffer were added to each well and the plates were incubated for 90minutes at 37° C. Wells were washed three times with PBT buffer. 100 μlof substrate buffer for HRP (25 ml of citrate buffer pH5, 10 mg ofO-phenildiamine and 10 μl of H₂O) were added to each well and the plateswere left at room temperature for 20 minutes. 100 μl H₂SO₄ was added toeach well and OD₄₉₀ was followed. The ELISA was considered positive whenOD490 was 2.5 times the respective pre-immune sera.

Alternatively, The acapsulated MenB M7 strain was plated on chocolateagar plates and incubated overnight at 37° C. Bacterial colonies werecollected from the agar plates using a sterile dracon swab andinoculated into Mueller-Hinton Broth (Difco) containing 0.25% Glucose.Bacterial growth was monitored every 30 minutes by following OD₆₂₀. Thebacteria were let to grow until the OD reached the value of 0.3-0.4. Theculture was centrifuged for 10 minutes at 10 000 rpm. The supernatantwas discarded and bacteria were washed once with PBS, resuspended in PBScontaining 0.025% formaldehyde, and incubated for 1 hour at 37° C. andthen overnight at 4° C. with stirring. 100 μl bacterial cells were addedto each well of a 96 well Greiner plate and incubated overnight at 4° C.The wells were then washed three times with PBT washing buffer (0.1%TWEEN-20™ in PBS). 200 μl of saturation buffer (2.7%Polyvinylpyrrolidone 10 in water) was added to each well and the platesincubated for 2 hours at 37° C. Wells were washed three times with PBT.200 μl of diluted sera (Dilution buffer: 1% BSA, 0.1% TWEEN-20™, 0.1%NaN₃ in PBS) were added to each well and the plates incubated for 2hours at 37° C. Wells were washed three times with PBT. 100 μl ofHRP-conjugated rabbit anti-mouse (Dako) serum diluted 1:2000 in dilutionbuffer were added to each well and the plates were incubated for 90minutes at 37° C. Wells were washed three times with PBT buffer. 100 μlof substrate buffer for HRP (25 ml of citrate buffer pH5, 10 mg ofO-phenildiamine and 10 μl of H₂O₂) were added to each well and theplates were left at room temperature for 20 minutes. 100 μl H₂SO₄ wasadded to each well and OD₄₉₀ was followed. The ELISA titers werecalculated arbitrarily as the dilution of sera which gave an OD₄₉₀ valueof 0.4 above the level of preimmune sera. The ELISA was consideredpositive when the dilution of sera with OD₄₉₀ of 0.4 was higher than1:400.

FACScan Bacteria Binding Assay Procedure.

The acapsulated MenB M7 strain was plated on chocolate agar plates andincubated overnight at 37° C. Bacterial colonies were collected from theagar plates using a sterile dracon swab and inoculated into 4 tubescontaining 8 ml each Mueller-Hinton Broth (Difco) containing 0.25%glucose. Bacterial growth was monitored every 30 minutes by followingOD₆₂₀. The bacteria were let to grow until the OD reached the value of0.35-0.5. The culture was centrifuged for 10 minutes at 4000 rpm. Thesupernatant was discarded and the pellet was resuspended in blockingbuffer (1% BSA, 0.4% NaN₃) and centrifuged for 5 minutes at 4000 rpm.Cells were resuspended in blocking buffer to reach OD₆₂₀ of 0.07. 100 μlbacterial cells were added to each well of a Costar 96 well plate. 100μl of diluted (1:200) sera (in blocking buffer) were added to each welland plates incubated for 2 hours at 4° C. Cells were centrifuged for 5minutes at 4000 rpm, the supernatant aspirated and cells washed byaddition of 200 μl/well of blocking buffer in each well. 100 μl ofR-Phicoerytrin conjugated F(ab)₂ goat anti-mouse, diluted 1:100, wasadded to each well and plates incubated for 1 hour at 4° C. Cells werespun down by centrifugation at 4000 rpm for 5 minutes and washed byaddition of 200 μl/well of blocking buffer. The supernatant wasaspirated and cells resuspended in 200 μl/well of PBS, 0.25%formaldehyde. Samples were transferred to FACScan tubes and read. Thecondition for FACScan setting were: FL1 on, FL2 and FL3 off; FSC-HTreshold:92; FSC PMT Voltage: E 02; SSC PMT: 474; Amp. Gains 7.1; FL-2PMT: 539. Compensation values: 0.

OMV Preparations

Bacteria were grown overnight on 5 GC plates, harvested with a loop andresuspended in 10 ml 20 mM Tris-HCl. Heat inactivation was performed at56° C. for 30 minutes and the bacteria disrupted by sonication for 10′on ice (50% duty cycle, 50% output). Unbroken cells were removed bycentrifugation at 5000 g for 10 minutes and the total cell envelopefraction recovered by centrifugation at 50000 g at 4° C. for 75 minutes.To extract cytoplasmic membrane proteins from the crude outer membranes,the whole fraction was resuspended in 2% sarkosyl (Sigma) and incubatedat room temperature for 20 minutes. The suspension was centrifuged at10000 g for 10 minutes to remove aggregates, and the supernatant furtherultracentrifuged at 50000 g for 75 minutes to pellet the outermembranes. The outer membranes were resuspended in 10 mM Tris-HCl, pH8and the protein concentration measured by the Bio-Rad Protein assay,using BSA as a standard.

Whole Extracts Preparation

Bacteria were grown overnight on a GC plate, harvested with a loop andresuspended in 1 ml of 20 mM Tris-HCl. Heat inactivation was performedat 56° C. for 30′ minutes.

Western Blotting

Purified proteins (500 ng/lane), outer membrane vesicles (5 μg) andtotal cell extracts (25 μg) derived from MenB strain 2996 were loadedonto a 12% SDS-polyacrylamide gel and transferred to a nitrocellulosemembrane. The transfer was performed for 2 hours at 150 mA at 4° C.,using transfer buffer (0.3% Tris base, 1.44% glycine, 20% (v/v)methanol). The membrane was saturated by overnight incubation at 4° C.in saturation buffer (10% skimmed milk, 0.1% TRITON X100™ in PBS). Themembrane was washed twice with washing buffer (3% skimmed milk, 0.1%TRITON X100™ in PBS) and incubated for 2 hours at 37° C. with mice seradiluted 1:200 in washing buffer. The membrane was washed twice andincubated for 90 minutes with a 1:2000 dilution of horseradishperoxidase labeled anti-mouse Ig. The membrane was washed twice with0.1% TRITON X100™ in PBS and developed with the OPTI-4CN SUBSTRATE KIT™(Bio-Rad). The reaction was stopped by adding water.

Bactericidal Assay

MC58 and 2996 strains were grown overnight at 37° C. on chocolate agarplates. 5-7 colonies were collected and used to inoculate 7 mlMueller-Hinton broth. The suspension was incubated at 37° C. on anutator and let to grow until OD₆₂₀ was in between 0.5-0.8. The culturewas aliquoted into sterile 1.5 ml Eppendorf tubes and centrifuged for 20minutes at maximum speed in a microfuge. The pellet was washed once inGey's buffer (Gibco) and resuspended in the same buffer to an OD₆₂₀ of0.5, diluted 1:20000 in Gey's buffer and stored at 25° C.

50 μl of Gey's buffer/1% BSA was added to each well of a 96-well tissueculture plate. 25 μl of diluted (1:100) mice sera (dilution buffer:Gey's buffer/0.2% BSA) were added to each well and the plate incubatedat 4° C. 25 μl of the previously described bacterial suspension wereadded to each well. 25 μl of either heat-inactivated (56° C. waterbathfor 30 minutes) or normal baby rabbit complement were added to eachwell. Immediately after the addition of the baby rabbit complement, 22μl of each sample/well were plated on Mueller-Hinton agar plates (time0). The 96-well plate was incubated for 1 hour at 37° C. with rotationand then 22 μl of each sample/well were plated on Mueller-Hinton agarplates (time 1). After overnight incubation the colonies correspondingto time 0 and time 1 h were counted.

Gene Variability

The ORF4 and 919 genes were amplified by PCR on chromosomal DNAextracted from various Neisseria strains (see list of strains). Thefollowing oligonucleotides used as PCR primers were designed in theupstream and downstream regions of the genes:

orf 4.1 (forward) (SEQ ID NO: 3266) CGAATCCGGACGGCAGGACTC orf 4.3(reverse) (SEQ ID NO: 3267) GGCAGGGAATGGCGGATTAAAG 919.1 (forward) (SEQID NO: 3268) AAAATGCCTCTCCACGGCTG or (SEQ ID NO: 3269)CTGCGCCCTGTGTTAAAATCCCCT 919.6 (reverse) (SEQ ID NO: 3270)CAAATAAGAAAGGAATTTTG or (SEQ ID NO: 3271) GGTATCGCAAAACTTCGCCTTAATGCGThe PCR cycling conditions were:

 1 cycle  2 min. at 94° 30 cycles 30 sec. at 94° 30 sec. at ~54°or ~60°(in according to Tm of the primers) 40 sec. at 72°  1 cycle  7 min. at72°The PCR products were purified from 1% agarose gel and sequenced usingthe following primers:

orf 4.1 (forward) (SEQ ID NO: 3272) CGAATCCGGACGGCAGGACTC orf 4.2(forward) (SEQ ID NO: 3273) CGACCGCGCCTTTGGGACTG orf 4.3 (reverse) (SEQID NO: 3274) GGCAGGGAATGGCGGATTAAAG orf 4.4 (reverse) (SEQ ID NO: 3275)TCTTTGAGTTTGATCCAACC 919.1 (forward) (SEQ ID NO: 3276)AAAATGCCTCTCCACGGCTG or (SEQ ID NO: 3277) CTGCGCCCTGTGTTAAAATCCCCT 919.2(forward) (SEQ ID NO: 3278) ATCCTTCCGCCTCGGCTGCG 919.3 (forward) (SEQ IDNO: 3279) AAAACAGCGGCACAATCGAC 919.4 (forward) (SEQ ID NO: 3280)ATAAGGGCTACCTCAAACTC 919.5 (forward) (SEQ ID NO: 3281)GCGCGTGGATTATTTTTGGG 919.6 (reverse) (SEQ ID NO: 3282)CAAATAAGAAAGGAATTTTG or (SEQ ID NO: 3283) GGTATCGCAAAACTTCGCCTTAATGCG919.7 (reverse) (SEQ ID NO: 3284) CCCAAGGTAATGTAGTGCCG 919.8 (reverse)(SEQ ID NO: 3285) TAAAAAAAAGTTCGACAGGG 919.9 (reverse) (SEQ ID NO: 3286)CCGTCCGCCTGTCGTCGCCC 919.10 (reverse) (SEQ ID NO: 3287)TCGTTCCGGCGGGGTCGGGG

All documents cited herein are incorporated by reference in theirentireties.

The following Examples are presented to illustrate, not limit, theinvention.

Example 1

Using the above-described procedures, the following oligonucleotideprimers were employed in the polymerase chain reaction (PCR) assay inorder to clone the ORFs as indicated:

TABLE 1 Oligonucleotides used for PCR for Examples 2-10 ORF PrimerSequence Restriction sites 279 ForwardCGCGGATCCCATATG-TTGCCTGCAATCACGATT BamHI-NdeI <SEQ ID 3021> ReverseCCCGCTCGAG-TTTAGAAGCGGGCGGCAA <SEQ XhoI ID 3022> 519 ForwardCGCGGATCCCATATG-TTCAAATCCTTTGTCGTCA BamHI-NdeI <SEQ ID 3023> ReverseCCCGCTCGAG-TTTGGCGGTTTTGCTGC <SEQ ID XhoI 3024> 576 ForwardCGCGGATCCCATATG-GCCGCCCCCGCATCT BamHI-NdeI <SEQ ID 3025> ReverseCCCGCTCGAG-ATTTACTTTTTTGATGTCGAC XhoI <SEQ ID 3026> 919 ForwardCGCGGATCCCATATG-TGCCAAAGCAAGAGCATC BamHI-NdeI <SEQ ID 3027> ReverseCCCGCTCGAG-CGGGCGGTATTCGGG <SEQ ID XhoI 3028> 121 ForwardCGCGGATCCCATATG-GAAACACAGCTTTACAT BamHI-NdeI <SEQ ID 3029> ReverseCCCGCTCGAG-ATAATAATATCCCGCGCCC <SEQ XhoI ID 3030> 128 ForwardCGCGGATCCCATATG-ACTGACAACGCACT <SEQ BamHI-NdeI ID 3031> ReverseCCCGCTCGAG-GACCGCGTTGTCGAAA <SEQ ID XhoI 3032> 206 ForwardCGCGGATCCCATATG-AAACACCGCCAACCGA BamHI-NdeI <SEQ ID 3033> ReverseCCCGCTCGAG-TTCTGTAAAAAAAGTATGTGC XhoI <SEQ ID 3034> 287 ForwardCCGGAATTCTAGCTAGC-CTTTCAGCCTGCGGG EcoRI-NheI <SEQ ID 3035> ReverseCCCGCTCGAG-ATCCTGCTCTTTTTTGCC <SEQ ID XhoI 3036> 406 ForwardCGCGGATCCCATATG-TGCGGGACACTGACAG BamHI-NdeI <SEQ ID 3037> ReverseCCCGCTCGAG-AGGTTGTCCTTGTCTATG <SEQ XhoI ID 3038>

Localization of the ORFs

The following DNA and amino acid sequences are identified by titles ofthe following form: [g, m, or a] [#].[seq or pep], where “g” means asequence from N. gonorrhoeae, “m” means a sequence from N. meningitidisB, and “a” means a sequence from N. meningitidis A; “#” means the numberof the sequence; “seq” means a DNA sequence, and “pep” means an aminoacid sequence. For example, “g001.seq” refers to an N. gonorrhoeae DNAsequence, number 1. The presence of the suffix “−1” to these sequencesindicates an additional sequence found for the same ORF, thus, data foran ORF having both an unsuffixed and a suffixed sequence designationapplies to both such designated sequences. Further, open reading framesare identified as ORF #, where “#” means the number of the ORF,corresponding to the number of the sequence which encodes the ORF, andthe ORF designations may be suffixed with “.ng” or “.a”, indicating thatthe ORF corresponds to a N. gonorrhoeae sequence or a N. meningitidis Asequence, respectively. The word “partial” before a sequence indicatesthat the sequence may be partial or a complete ORF. Computer analysiswas performed for the comparisons that follow between “g”, “m”, and “a”peptide sequences; and therein the “pep” suffix is implied where notexpressly stated. Further, in the event of a conflict between the textimmediately preceding and describing which sequences are being compared,and the designated sequences being compared, the designated sequencecontrols and is the actual sequence being compared

ORF: contig: 279 gnm4.seqThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 3039>:

m279.seq 1 ATAACGCGGA TTTGCGGCTG CTTGATTTCA ACGGTTTTCA GGGCTTCGGC 51AAGTTTGTCG GCGGCGGGTT TCATCAGGCT GCAATGGGAA GGTACGGACA 101 CGGGCAGCGGCAGGGCGCGT TTGGCACCGG CTTCTTTGGC GGCAGCCATG 151 GCGCGTCCGA CGGCGGCGGCGTTGCCTGCA ATCACGATTT GTCCGGGTGA 201 GTTGAAGTTG ACGGCTTCGA CCACTTCGCTTTGGGCGGCT TCGGCACAAA 251 TGGCTTTAAC CTGCTCATCT TCCAAGCCGA GAATCGCCGCCATTGCGCCC 301 ACGCCTTGCG GTACGGCGGA CTGCATCAGT TCGGCGCGCA GGCGCACGAG351 TTTGACCGCG TCGGCAAAAT TCAATGCGCC GGCGGCAACG AGTGCGGTGT 401ATTCGCCGAG GCTGTGTCCG GCAACGGCGG CAGGCGTTTT GCCGCCCGCT 451 TCTAAATAGThis corresponds to the amino acid sequence <SEQ ID 3040; ORF 279>:

m279.pep 1 ITRICGCLIS TVFRASASLS AAGFIRLQWE GTDTGSGRAR LAPASLAAAM 51ARPTAAALPA ITICPGELKL TASTTSLWAA SAQMALTCSS SKPRIAAIAP 101 TPCGTADCISSARRRTSLTA SAKFNAPAAT SAVYSPRLCP ATAAGVLPPA 151 SK*The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 3041>:

g279.seq 1 atgacgcgga tttgcggctg cttgatttca acggttttga gtgtttcggc 51aagtttgtcg gcggcgggtt tcatcaggct gcaatgggaa ggaacggata 101 ccggcagcggcagggcgcgt ttggctccgg cttctttggc ggcagccatg 151 gtgcgtccga cggcggcggcgttgcctgca atcacgactt gtccgggcga 201 gttgaagttg acggcttcga ccacttcgccctgtgcggat tcggcacaaa 251 tctgcctgac ctgttcatct tccaaaccca aaatggccgccattgcgcct 301 acgccttgcg gtacggcgga ctgcatcagt tcggcgcgca ggcggacgag351 tttgacggca tcggcaaaat ccaatgcttc ggcggcgaca agcgcggtgt 401attcgccgag gctgtgtccg gcaacggcgg caggcgtttt gccgcccact 451 tccaaatagThis corresponds to the amino acid sequence <SEQ ID 3042; ORF 279.ng>:

g279.pep 1 MTRICGCLIS TVLSVSASLS AAGFIRLQWE GTDTGSGRAR LAPASLAAAM 51VRPTAAALPA ITTCPGELKL TASTTSPCAD SAQICLTCSS SKPKMAAIAP 101 TPCGTADCISSARRRTSLTA SAKSNASAAT SAVYSPRLCP ATAAGVLPPT 151 SK*ORF 279 shows 89.5% identity over a 152 aa overlap with a predicted ORF(ORF 279.ng) from N. gonorrhoeae:

        10        20        30        40        50        60 m279.pepITRICGCLISTVFRASASLSAAGFIRLQWEGTDTGSGRARLAPASLAAAMARPTAAALPA:|||||||||||: :|||||||||||||||||||||||||||||||||||:||||||||| g279MTRICGCLISTVLSVSASLSAAGFIRLQWEGTDTGSGRARLAPASLAAAMVRPTAAALPA        10        20        30        40        50        60        70        80        90       100       110       120 m279.pepITICPGELKLTASTTSLWAASAQMALTCSSSKPRIAAIAPTPCGTADCISSARRRTSLTA|| |||||||||||||  | |||: ||||||||::||||||||||||||||||||||||| g279ITTCPGELKLTASTTSPCADSAQICLTCSSSKPKMAAIAPTPCGTADCISSARRRTSLTA        70        80        90       100       110       120       130       140       150 m279.pepSAKFNAPAATSAVYSPRLCPATAAGVLPPASKX ||| || ||||||||||||||||||||||:||| g279SAKSNASAATSAVYSPRLCPATAAGVLPPTSKX        130       140       150The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3043>:

a279.seq 1 ATGACNCNGA TTTGCGGCTG CTTGATTTCA ACGGTTTNNA GGGCTTCGGC 51GAGTTTGTCG GCGGCGGGTT TCATGAGGCT GCAATGGGAA GGTACNGACA 101 CNGGCAGCGGCAGGGCGCGT TTGGCGCCGG CTTCTTTGGC GGCAAGCATA 151 GCGCGCTCGA CGGCGGCGGCATTGCCTGCA ATCACGACTT GTCCGGGCGA 201 GTTGAAGTTG ACGGCTTCAA CCACTTCATCCTGTGCGGAT TCGGCGCAAA 251 TTTGTTTTAC CTGTTCATCT TCCAAGCCGA GAATCGCCGCCATTGCGCCC 301 ACGCCTTGCG GTACGGCGGA CTGCATCAGT TCGGCGCGCA NGCGCACGAG351 TTTGACCGCG TCGGCAAAAT CCAATGCGCC GGCGGCAACN AGTGCGGTGT 401ATTCGCCGAN GCTGTGTCCG GCAACGGCGG CAGGCGTTTT GCCGCCCGCT 451 TCCGAATAGThis corresponds to the amino acid sequence <SEQ ID 3044; ORF 279.a>:

a279.pep 1 MTXICGCLIS TVXRASASLS AAGFMRLQWE GTDTGSGRAR LAPASLAASI 51ARSTAAALPA ITTCPGELKL TASTTSSCAD SAQICFTCSS SKPRIAAIAP 101 TPCGTADCISSARXRTSLTA SAKSNAPAAT SAVYSPXLCP ATAAGVLPPA 151 SE*m279/a279 ORFs 279 and 279.a showed a 88.2% identity in 152 aa overlap

        10        20        30        40        50        60 m279.pepITRICGCLISTVFRASASLSAAGFIRLQWEGTDTGSGRARLAPASLAAAMARPTAAALPA:| ||||||||| |||||||||||:|||||||||||||||||||||||::|| ||||||| a279MTXICGCLISTVXRASASLSAAGFMRLQWEGTDTGSGRARLAPASLAASIARSTAAALPA        10        20        30        40        50        60        70        80        90       100       110       120 m279.pepITICPGELKLTASTTSLWAASAQMALTCSSSKPRIAAIAPTPCGTADCISSARRRTSLTA|| |||||||||||||  | |||: :||||||||||||||||||||||||||| |||||| a279ITTCPGELKLTASTTSSCADSAQICFTCSSSKPRIAAIAPTPCGTADCISSARXRTSLTA        70        80        90       100       110       120       130       140       150 m279.pepSAKFNAPAATSAVYSPRLCPATAAGVLPPASKX ||| |||||||||||| ||||||||||||||:| a279SAKSNAPAATSAVYSPXLCPATAAGVLPPASEX        130       140       150519 and 519-1 gnm7.seqThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 3045>:

m519.seq (partial) 1 ..TCCGTTATCG GGCGTATGGA GTTGGACAAA ACGTTTGAAGAACGCGACGA 51   AATCAACAGT ACTGTTGTTG CGGCTTTGGA CGAGGCGGCC GGGgCTTgGG101   GTGTGAAGGT TTTGCGTTAT GAGATTAAAG ACTTGGTTCC GCCGCAAGAA 151  ATCCTTCGCT CAATGCAGGC GCAAATTACT GCCGAACGCG AAAAACGCGC 201  CCGTATCGCC GAATCCGAAG GTCGTAAAAT CGAACAAATC AACCTTGCCA 251  GTGGTCAGCG CGAAGCCGAA ATCCAACAAT CCGAAGGCGA GGCTCAGGCT 301  GCGGTCAATG CGTCAAATGC CGAGAAAATC GCCCGCATCA ACCGCGCCAA 351  AGGTGAAGCG GAATCCTTGC GCCTTGTTGC CGAAGCCAAT GCCGAAGCCA 401  TCCGTCAAAT TGCCGCCGCC CTTCAAACCC AAGGCGGTGC GGATGCGGTC 451  AATCTGAAGA TTGCGGAACA ATACGTCGCT GCGTTCAACA ATCTTGCCAA 501  AGAAAGCAAT ACGCTGATTA TGCCCGCCAA TGTTGCCGAC ATCGGCAGCC 551  TGATTTCTGC CGGTATGAAA ATTATCGACA GCAGCAAAAC CGCCAAaTAAThis corresponds to the amino acid sequence <SEQ ID 3046; ORF 519>:

m519.pep (partial) 1 ..SVIGRMELDK TFEERDEINS TVVAALDEAA GAWGVKVLRYEIKDLVPPQE 51   ILRSMQAQIT AEREKRARIA ESEGRKIEQI NLASGQREAE IQQSEGEAQA101   AVNASNAEKI ARINRAKGEA ESLRLVAEAN AEAIRQIAAA LQTQGGADAV 151  NLKIAEQYVA AFNNLAKESN TLIMPANVAD IGSLISAGMK IIDSSKTAK*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3047>:

g519.seq 1 atggaatttt tcattatctt gttggcagcc gtcgccgttt tcggcttcaa 51atcctttgtc gtcatccccc agcaggaagt ccacgttgtc gaaaggctcg 101 ggcgtttccatcgcgccctg acggccggtt tgaatatttt gattcccttt 151 atcgaccgcg tcgcctaccgccattcgctg aaagaaatcc ctttagacgt 201 acccagccag gtctgcatca cgcgcgataatacgcaattg actgttgacg 251 gcatcatcta tttccaagta accgatccca aactcgcctcatacggttcg 301 agcaactaca ttatggcaat tacccagctt gcccaaacga cgctgcgttc351 cgttatcggg cgtatggagt tggacaaaac gtttgaagaa cgcgacgaaa 401tcaacagtac cgtcgtctcc gccctcgatg aagccgccgg ggcttggggt 451 gtgaaagtcctccgttacga aatcaaggat ttggttccgc cgcaagaaat 501 ccttcgcgca atgcaggcacaaattaccgc cgaacgcgaa aaacgcgccc 551 gtattgccga atccgaaggc cgtaaaatcgaacaaatcaa ccttgccagt 601 ggtcagcgtg aagccgaaat ccaacaatcc gaaggcgaggctcaggctgc 651 ggtcaatgcg tccaatgccg agaaaatcgc ccgcatcaac cgcgccaaag701 gcgaagcgga atccctgcgc cttgttgccg aagccaatgc cgaagccaac 751cgtcaaattg ccgccgccct tcaaacccaa agcggggcgg atgcggtcaa 801 tctgaagattgcgggacaat acgttaccgc gttcaaaaat cttgccaaag 851 aagacaatac gcggattaagcccgccaagg ttgccgaaat cgggaaccct 901 aattttcggc ggcatgaaaa attttcgccagaagcaaaaa cggccaaata 951 aThis corresponds to the amino acid sequence <SEQ ID 3048; ORF 519.ng>:

g519.pep 1 MEFFIILLAA VAVFGFKSFV VIPQQEVHVV ERLGRFHRAL TAGLNILIPF 51IDRVAYRHSL KEIPLDVPSQ VCITRDNTQL TVDGIIYFQV TDPKLASYGS 101 SNYIMAITQLAQTTLRSVIG RMELDKTFEE RDEINSTVVS ALDEAAGAWG 151 VKVLRYEIKD LVPPQEILRAMQAQITAERE KRARIAESEG RKIEQINLAS 201 GQREAEIQQS EGEAQAAVNA SNAEKIARINRAKGEAESLR LVAEANAEAN 251 RQIAAALQTQ SGADAVNLKI AGQYVTAFKN LAKEDNTRIKPAKVAEIGNP 301 NFRRHEKFSP EAKTAK*ORF 519 shows 87.5% identity over a 200 aa overlap with a predicted ORF(ORF 519.ng) from N. gonorrhoeae:

m519/g519                                       10        20        30m519.pep                               SVIGRMELDKTFEERDEINSTVVAALDEAA                              |||||||||||||||||||||||:|||||| g519YFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVSALDEAA  90       100       110       120       130       140        40        50        60        70        80        90 m519.pepGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAE|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| g519GAWGVKVLRYEIKDLVPPQEILRAMQAQITAEREKRARIAESEGRKIEQINLASGQREAE 150       160       170       180       190       200       100       110       120       130       140       150 m519.pepIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAV||||||||||||||||||||||||||||||||||||||||||| ||||||||||:||||| g519IQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEANRQIAAALQTQSGADAV 210       220       230       240       250       260       160       170       180        190       200 m519.pepNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL-ISAGMKIIDSSKTAK||||| |||:||:|||||:|| | ||:||:||:  :    |:   :|||| g519NLKIAGQYVTAFKNLAKEDNTRIKPAKVAEIGNPNFRRHEKFSPEAKTAK 270       280       290       300       310The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3049>:

a519.seq 1 ATGGAATTTT TCATTATCTT GCTGGCAGCC GTCGTTGTTT TCGGCTTCAA 51ATCCTTTGTT GTCATCCCAC AGCAGGAAGT CCACGTTGTC GAAAGGCTCG 101 GGCGTTTCCATCGCGCCCTG ACGGCCGGTT TGAATATTTT GATTCCCTTT 151 ATCGACCGCG TCGCCTACCGCCATTCGCTG AAAGAAATCC CTTTAGACGT 201 ACCCAGCCAG GTCTGCATCA CGCGCGACAATACGCAGCTG ACTGTTGACG 251 GTATCATCTA TTTCCAAGTA ACCGACCCCA AACTCGCCTCATACGGTTCG 301 AGCAACTACA TTATGGCGAT TACCCAGCTT GCCCAAACGA CGCTGCGTTC351 CGTTATCGGG CGTATGGAAT TGGACAAAAC GTTTGAAGAA CGCGACGAAA 401TCAACAGCAC CGTCGTCTCC GCCCTCGATG AAGCCGCCGG AGCTTGGGGT 451 GTGAAGGTTTTGCGTTATGA GATTAAAGAC TTGGTTCCGC CGCAAGAAAT 501 CCTTCGCTCA ATGCAGGCGCAAATTACTGC TGAACGCGAA AAACGCGCCC 551 GTATCGCCGA ATCCGAAGGT CGTAAAATCGAACAAATCAA CCTTGCCAGT 601 GGTCAGCGCG AAGCCGAAAT CCAACAATCC GAAGGCGAGGCTCAGGCTGC 651 GGTCAATGCG TCAAATGCCG AGAAAATCGC CCGCATCAAC CGCGCCAAAG701 GTGAAGCGGA ATCCTTGCGC CTTGTTGCCG AAGCCAATGC CGAAGCCATC 751CGTCAAATTG CCGCCGCCCT TCAAACCCAA GGCGGTGCGG ATGCGGTCAA 801 TCTGAAGATTGCGGAACAAT ACGTCGCCGC GTTCAACAAT CTTGCCAAAG 851 AAAGCAATAC GCTGATTATGCCCGCCAATG TTGCCGACAT CGGCAGCCTG 901 ATTTCTGCCG GTATGAAAAT TATCGACAGCAGCAAAACCG CCAAATAAThis corresponds to the amino acid sequence <SEQ ID 3050; ORF 519.a>:

a519.pep 1 MEFFIILLAA VVVFGFKSFV VIPQQEVHVV ERLGRFHRAL TAGLNILIPF 51IDRVAYRHSL KEIPLDVPSQ VCITRDNTQL TVDGIIYFQV TDPKLASYGS 101 SNYIMAITQLAQTTLRSVIG RMELDKTFEE RDEINSTVVS ALDEAAGAWG 151 VKVLRYEIKD LVPPQEILRSMQAQITAERE KRARIAESEG RKIEQINLAS 201 GQREAEIQQS EGEAQAAVNA SNAEKIARINRAKGEAESLR LVAEANAEAI 251 RQIAAALQTQ GGADAVNLKI AEQYVAAFNN LAKESNTLIMPANVADIGSL 301 ISAGMKIIDS SKTAK* m519/a519 ORFs 519 and 519.a showed a99.5% identity in 199 aa overlap                                      10        20        30 m519.pep                              SVIGRMELDKTFEERDEINSTVVAALDEAA                              |||||||||||||||||||||||:|||||| a519YFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVSALDEAA  90       100       110       120       130       140        40        50        60        70        80        90 m519.pepGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a519GAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAE 150       160       170       180       190       200       100       110       120       130       140       150 m519.pepIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a519IQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAV 210       220       230       240       250       260       160       170       180       190       200 m519.pepNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSLISAGMKIIDSSKTAKX|||||||||||||||||||||||||||||||||||||||||||||||||| a519NLKIAEQYVAAFNNLAKESNTLIMPANVADIGSLISAGMKIIDSSKTAKX 270       280       290       300       310Further work revealed the DNA sequence identified in N. meningitidis<SEQ ID 3051>:

m519-1.seq 1 ATGGAATTTT TCATTATCTT GTTGGTAGCC GTCGCCGTTT TCGGTTTCAA 51ATCCTTTGTT GTCATCCCAC AACAGGAAGT CCACGTTGTC GAAAGGCTGG 101 GGCGTTTCCATCGCGCCCTG ACGGcCGGTT TGAATATTTT GATTCCCTTT 151 ATCGACCGCG TCGCCTACCGCCATTCGCTG AAAGAAATCC CTTTAGACGT 201 ACCCAGCCAG GTCTGCATCA CGCGCGACAATACGCAGCTG ACTGTTGACG 251 GCATCATCTA TTTCCAAGTA ACCGACCCCA AACTCGCCTCATACGGTTCG 301 AGCAACTACA TTATGGCGAT TACCCAGCTT GCCCAAACGA CGCTGCGTTC351 CGTTATCGGG CGTATGGAGT TGGACAAAAC GTTTGAAGAA CGCGACGAAA 401TCAACAGTAC TGTTGTTGCG GCTTTGGACG AGGCGGCCGG GGCTTGGGGT 451 GTGAAGGTTTTGCGTTATGA GATTAAAGAC TTGGTTCCGC CGCAAGAAAT 501 CCTTCGCTCA ATGCAGGCGCAAATTACTGC CGAACGCGAA AAACGCGCCC 551 GTATCGCCGA ATCCGAAGGT CGTAAAATCGAACAAATCAA CCTTGCCAGT 601 GGTCAGCGCG AAGCCGAAAT CCAACAATCC GAAGGCGAGGCTCAGGCTGC 651 GGTCAATGCG TCAAATGCCG AGAAAATCGC CCGCATCAAC CGCGCCAAAG701 GTGAAGCGGA ATCCTTGCGC CTTGTTGCCG AAGCCAATGC CGAAGCCATC 751CGTCAAATTG CCGCCGCCCT TCAAACCCAA GGCGGTGCGG ATGCGGTCAA 801 TCTGAAGATTGCGGAACAAT ACGTCGCTGC GTTCAACAAT CTTGCCAAAG 851 AAAGCAATAC GCTGATTATGCCCGCCAATG TTGCCGACAT CGGCAGCCTG 901 ATTTCTGCCG GTATGAAAAT TATCGACAGCAGCAAAACCG CCAAATAAThis corresponds to the amino acid sequence <SEQ ID 3052; ORF 519-1>:

m519-1. 1 MEFFIILLVA VAVFGFKSFV VIPQQEVHVV ERLGRFHRAL TAGLNILIPF 51IDRVAYRHSL KEIPLDVPSQ VCITRDNTQL TVDGIIYFQV TDPKLASYGS 101 SNYIMAITQLAQTTLRSVIG RMELDKTFEE RDEINSTVVA ALDEAAGAWG 151 VKVLRYEIKD LVPPQEILRSMQAQITAERE KRARIAESEG RKIEQINLAS 201 GQREAEIQQS EGEAQAAVNA SNAEKIARINRAKGEAESLR LVAEANAEAI 251 RQIAAALQTQ GGADAVNLKI AEQYVAAFNN LAKESNTLIMPANVADIGSL 301 ISAGMKIIDS SKTAK*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3053>:

g519-1.seq 1 ATGGAATTTT TCATTATCTT GTTGGCAGCC GTCGCCGTTT TCGGCTTCAA 51ATCCTTTGTC GTCATCCCCC AGCAGGAAGT CCACGTTGTC GAAAGGCTCG 101 GGCGTTTCCATCGCGCCCTG ACGGCCGGTT TGAATATTTT GATTCCCTTT 151 ATCGACCGCG TCGCCTACCGCCATTCGCTG AAAGAAATCC CTTTAGACGT 201 ACCCAGCCAG GTCTGCATCA CGCGCGATAATACGCAATTG ACTGTTGACG 251 GCATCATCTA TTTCCAAGTA ACCGATCCCA AACTCGCCTCATACGGTTCG 301 AGCAACTACA TTATGGCAAT TACCCAGCTT GCCCAAACGA CGCTGCGTTC351 CGTTATCGGG CGTATGGAGT TGGACAAAAC GTTTGAAGAA CGCGACGAAA 401TCAACAGTAC CGTCGTCTCC GCCCTCGATG AAGCCGCCGG GGCTTGGGGT 451 GTGAAAGTCCTCCGTTACGA AATCAAGGAT TTGGTTCCGC CGCAAGAAAT 501 CCTTCGCGCA ATGCAGGCACAAATTACCGC CGAACGCGAA AAACGCGCCC 551 GTATTGCCGA ATCCGAAGGC CGTAAAATCGAACAAATCAA CCTTGCCAGT 601 GGTCAGCGTG AAGCCGAAAT CCAACAATCC GAAGGCGAGGCTCAGGCTGC 651 GGTCAATGCG TCCAATGCCG AGAAAATCGC CCGCATCAAC CGCGCCAAAG701 GCGAAGCGGA ATCCCTGCGC CTTGTTGCCG AAGCCAATGC CGAAGCCATC 751CGTCAAATTG CCGCCGCCCT TCAAACCCAA GGCGGGGCGG ATGCGGTCAA 801 TCTGAAGATTGCGGAACAAT ACGTAGCCGC GTTCAACAAT CTTGCCAAAG 851 AAAGCAATAC GCTGATTATGCCCGCCAATG TTGCCGACAT CGGCAGCCTG 901 ATTTCTGCCG GCATGAAAAT TATCGACAGCAGCAAAACCG CCAAATAAThis corresponds to the amino acid sequence <SEQ ID 3054; ORF 519-1.ng>:

g519-1.pep 1 MEFFIILLAA VAVFGFKSFV VIPQQEVHVV ERLGRFHRAL TAGLNILIPF 51IDRVAYRHSL KEIPLDVPSQ VCITRDNTQL TVDGIIYFQV TDPKLASYGS 101 SNYIMAITQLAQTTLRSVIG RMELDKTFEE RDEINSTVVS ALDEAAGAWG 151 VKVLRYEIKD LVPPQEILRAMQAQITAERE KRARIAESEG RKIEQINLAS 201 GQREAEIQQS EGEAQAAVNA SNAEKIARINRAKGEAESLR LVAEANAEAI 251 RQIAAALQTQ GGADAVNLKI AEQYVAAFNN LAKESNTLIMPANVADIGSL 301 ISAGMKIIDS SKTAK* m519-1/g519-1 99.0% identity in 315 aaoverlap         10        20        30        40        50        60g519-1.pep MEFFIILLAAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSL||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSL        10        20        30        40        50        60        70        80        90       100       110       120 g519-1.pepKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1KEIPLDVPSQVCITRDNTQLTVDGIIYFQVIDPKLASYGSSNYIMAITQLAQTTLRSVIG        70        80        90       100       110       120       130       140       150       160       170       180 g519-1.pepRMELDKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRAMQAQITAERE|||||||||||||||||||:|||||||||||||||||||||||||||||:|||||||||| m519-1RMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAERE       130       140       150       160       170       180       190       200       210       220       230       240 g519-1.pepKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1KRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLR       190       200       210       220       230       240       250       260       270       280       290       300 g519-1.pepLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1LVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL       250       260       270       280       290       300        310g519-1.pep ISAGMKIIDSSKTAKX |||||||||||||||| m519-1 ISAGMKIIDSSKTAKX       310The following DNA sequence was identified in N. meningitidis <SEQ ID3055>:

a519-1.seq 1 ATGGAATTTT TCATTATCTT GCTGGCAGCC GTCGTTGTTT TCGGCTTCAA 51ATCCTTTGTT GTCATCCCAC AGCAGGAAGT CCACGTTGTC GAAAGGCTCG 101 GGCGTTTCCATCGCGCCCTG ACGGCCGGTT TGAATATTTT GATTCCCTTT 151 ATCGACCGCG TCGCCTACCGCCATTCGCTG AAAGAAATCC CTTTAGACGT 201 ACCCAGCCAG GTCTGCATCA CGCGCGACAATACGCAGCTG ACTGTTGACG 251 GTATCATCTA TTTCCAAGTA ACCGACCCCA AACTCGCCTCATACGGTTCG 301 AGCAACTACA TTATGGCGAT TACCCAGCTT GCCCAAACGA CGCTGCGTTC351 CGTTATCGGG CGTATGGAAT TGGACAAAAC GTTTGAAGAA CGCGACGAAA 401TCAACAGCAC CGTCGTCTCC GCCCTCGATG AAGCCGCCGG AGCTTGGGGT 451 GTGAAGGTTTTGCGTTATGA GATTAAAGAC TTGGTTCCGC CGCAAGAAAT 501 CCTTCGCTCA ATGCAGGCGCAAATTACTGC TGAACGCGAA AAACGCGCCC 551 GTATCGCCGA ATCCGAAGGT CGTAAAATCGAACAAATCAA CCTTGCCAGT 601 GGTCAGCGCG AAGCCGAAAT CCAACAATCC GAAGGCGAGGCTCAGGCTGC 651 GGTCAATGCG TCAAATGCCG AGAAAATCGC CCGCATCAAC CGCGCCAAAG701 GTGAAGCGGA ATCCTTGCGC CTTGTTGCCG AAGCCAATGC CGAAGCCATC 751CGTCAAATTG CCGCCGCCCT TCAAACCCAA GGCGGTGCGG ATGCGGTCAA 801 TCTGAAGATTGCGGAACAAT ACGTCGCCGC GTTCAACAAT CTTGCCAAAG 851 AAAGCAATAC GCTGATTATGCCCGCCAATG TTGCCGACAT CGGCAGCCTG 901 ATTTCTGCCG GTATGAAAAT TATCGACAGCAGCAAAACCG CCAAATAAThis corresponds to the amino acid sequence <SEQ ID 3056; ORF 519-1.a>:

a519-1.pep. 1 MEFFIILLAA VVVFGFKSFV VIPQQEVHVV ERLGRFHRAL TAGLNILIPF 51IDRVAYRHSL KEIPLDVPSQ VCITRDNTQL TVDGIIYFQV TDPKLASYGS 101 SNYIMAITQLAQTTLRSVIG RMELDKTFEE RDEINSTVVS ALDEAAGAWG 151 VKVLRYEIKD LVPPQEILRSMQAQITAERE KRARIAESEG RKIEQINLAS 201 GQREAEIQQS EGEAQAAVNA SNAEKIARINRAKGEAESLR LVAEANAEAI 251 RQIAAALQTQ GGADAVNLKI AEQYVAAFNN LAKESNTLIMPANVADIGSL 301 ISAGMKIIDS SKTAK* m519-1/a519-1 ORFs 519-1 and 519-1.ashowed a 99.0% identity in 315 aa overlap        10        20        30        40        50        60 a519-1.pepMEFFIILLAAVVVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSL||||||||:||:|||||||||||||||||||||||||||||||||||||||||||||||| m519-1MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSL        10        20        30        40        50        60        70        80        90       100       110       120 a519-1.pepKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1KEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIG        70        80        90       100       110       120       130       140       150       160       170       180 a519-1.pepRMELDKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAERE|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||| m519-1RMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAERE       130       140       150       160       170       180       190       200       210       220       230       240 a519-1.pepKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1KRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLR       190       200       210       220       230       240       250       260       270       280       290       300 a519-1.pepLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1LVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL       250       260       270       280       290       300        310a519-1.pep ISAGMKIIDSSKTAKX |||||||||||||||| m519-1 ISAGMKIIDSSKTAKX       310576 and 576-1 gnm22.seqThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 3057>:

m576.seq.. (partial) 1 ..ATGCAGCAGG CAAGCTATGC GATGGGCGTG GACATCGGACGCTCCCTGAA 51   GCAAATGAAG GAACAGGGCG CGGAAATCGA TTTGAAAGTC TTTACCGAAG101   CCATGCAGGC AGTGTATGAC GGCAAAGAAA TCAAAATGAC CGAAGAGCAG 151  GCTCAGGAAG TCATGATGAA ATTCCTTCAG GAACAACAGG CTAAAGCCGT 201  AGAAAAACAC AAGGCGGACG CGAAGGCCAA TAAAGAAAAA GGCGAAGCCT 251  TTCTGAAAGA AAATGCCGCC AAAGACGGCG TGAAGACCAC TGCTTCCGGC 301  CTGCAATACA AAATCACCAA ACAGGGCGAA GGCAAACAGC CGACCAAAGA 351  CGACATCGTT ACCGTGGAAT ACGAAGGCCG CCTGATTGAC GGTACGGTAT 401  TCGACAGCAG CAAAGCCAAC GGCGGCCCGG TCACCTTCCC TTTGAGCCAA 451  GTGATTCCGG GTTGGACCGA AGgCGTACAG CTTCTGAAAG AAGGCGGCGA 501  AGCCACGTTC TACATCCCGT CCAACCTTGC CTACCGCGAA CAGGGTGCGG 551  GCGACAAAAT CGGTCCGAAC GCCACTTTGG TATTTGATGT GAAACTGGTC 601  AAAATCGGCG CACCCGAAAA CGCGCCCGCC AAGCAGCCGG CTCAAGTCGA 651  CATCAAAAAA GTAAATTAAThis corresponds to the amino acid sequence <SEQ ID 3058; ORF 576>:

m576.pep.. (partial) 1 ..MQQASYAMGV DIGRSLKQMK EQGAEIDLKV FTEAMQAVYDGKEIKMTEEQ 51   AQEVMMKFLQ EQQAKAVEKH KADAKANKEK GEAFLKENAA KDGVKTTASG101   LQYKITKQGE GKQPTKDDIV TVEYEGRLID GTVFDSSKAN GGPVTFPLSQ 151  VIPGWTEGVQ LLKEGGEATF YIPSNLAYRE QGAGDKIGPN ATLVFDVKLV 201  KIGAPENAPA KQPAQVDIKK VN*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3059>:

g576.seq.. (partial) 1 ..atgggcgtgg acatcggacg ctccctgaaa caaatgaaggaacagggcgc 51   ggaaatcgat ttgaaagtct ttaccgatgc catgcaggca gtgtatgacg101   gcaaagaaat caaaatgacc gaagagcagg cccaggaagt gatgatgaaa 151  ttcctgcagg agcagcaggc taaagccgta gaaaaacaca aggcggatgc 201  gaaggccaac aaagaaaaag gcgaagcctt cctgaaggaa aatgccgccg 251  aagacggcgt gaagaccact gcttccggtc tgcagtacaa aatcaccaaa 301  cagggtgaag gcaaacagcc gacaaaagac gacatcgtta ccgtggaata 351  cgaaggccgc ctgattgacg gtaccgtatt cgacagcagc aaagccaacg 401  gcggcccggc caccttccct ttgagccaag tgattccggg ttggaccgaa 451  ggcgtacggc ttctgaaaga aggcggcgaa gccacgttct acatcccgtc 501  caaccttgcc taccgcgaac agggtgcggg cgaaaaaatc ggtccgaacg 551  ccactttggt atttgacgtg aaactggtca aaatcggcgc acccgaaaac 601  gcgcccgcca agcagccgga tcaagtcgac atcaaaaaag taaattaaThis corresponds to the amino acid sequence <SEQ ID 3060; ORF 576.ng>:

g576.pep.. (partial) 1 ..MGVDIGRSLK QMKEQGAEID LKVFTDAMQA VYDGKEIKMTEEQAQEVMMK 51   FLQEQQAKAV EKHKADAKAN KEKGEAFLKE NAAEDGVKTT ASGLQYKITK101   QGEGKQPTKD DIVTVEYEGR LIDGTVFDSS KANGGPATFP LSQVIPGWTE 151  GVRLLKEGGE ATFYIPSNLA YREQGAGEKI GPNATLVFDV KLVKIGAPEN 201  APAKQPDQVD IKKVN*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m576/g576 97.2% identity in 215 aa overlap        10        20        30        40        50        60 m576.pepMQQASYAMGVDIGRSLKQMKEQGAEIDLKVFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQ       |||||||||||||||||||||||||:||||||||||||||||||||||||||| g576       MGVDIGRSLKQMKEQGAEIDLKVFTDAMQAVYDGKEIKMTEEQAQEVMMKFLQ               10        20        30        40        50        70        80        90       100       110       120 m576.pepEQQAKAVEKHKADAKANKEKGEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIV||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||| g576EQQAKAVEKHKADAKANKEKGEAFLKENAAEDGVKTTASGLQYKITKQGEGKQPTKDDIV     60        70        80        90       100       110       130       140       150       160       170       180 m576.pepTVEYEGRLIDGTVFDSSKANGGPVTFPLSQVIPGWTEGVQLLKEGGEATFYIPSNLAYRE|||||||||||||||||||||||:|||||||||||||||:|||||||||||||||||||| g576TVEYEGRLIDGTVFDSSKANGGPATFPLSQVIPGWTEGVRLLKEGGEATFYIPSNLAYRE    120       130       140       150       160       170       190       200       210       220 m576.pepQGAGDKIGPNATLVFDVKLVKIGAPENAPAKQPAQVDIKKVNX||||:|||||||||||||||||||||||||||| ||||||||| g576QGAGEKIGPNATLVFDVKLVKIGAPENAPAKQPDQVDIKKVNX    180       190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3061>:

a576.seq 1 ATGAACACCA TTTTCAAAAT CAGCGCACTG ACCCTTTCCG CCGCTTTGGC 51ACTTTCCGCC TGCGGCAAAA AAGAAGCCGC CCCCGCATCT GCATCCGAAC 101 CTGCCGCCGCTTCTTCCGCG CAGGGCGACA CCTCTTCGAT CGGCAGCACG 151 ATGCAGCAGG CAAGCTATGCGATGGGCGTG GACATCGGAC GCTCCCTGAA 201 GCAAATGAAG GAACAGGGCG CGGAAATCGATTTGAAAGTC TTTACCGAAG 251 CCATGCAGGC AGTGTATGAC GGCAAAGAAA TCAAAATGACCGAAGAGCAG 301 GCTCAGGAAG TCATGATGAA ATTCCTTCAG GAACAACAGG CTAAAGCCGT351 AGAAAAACAC AAGGCGGACG CGAAGGCCAA TAAAGAAAAA GGCGAAGCCT 401TTCTGAAAGA AAATGCCGCC AAAGACGGCG TGAAGACCAC TGCTTCCGGC 451 CTGCAATACAAAATCACCAA ACAGGGCGAA GGCAAACAGC CGACCAAAGA 501 CGACATCGTT ACCGTGGAATACGAAGGCCG CCTGATTGAC GGTACGGTAT 551 TCGACAGCAG CAAAGCCAAC GGCGGCCCGGTCACCTTCCC TTTGAGCCAA 601 GTGATTCTGG GTTGGACCGA AGGCGTACAG CTTCTGAAAGAAGGCGGCGA 651 AGCCACGTTC TACATCCCGT CCAACCTTGC CTACCGCGAA CAGGGTGCGG701 GCGACAAAAT CGGCCCGAAC GCCACTTTGG TATTTGATGT GAAACTGGTC 751AAAATCGGCG CACCCGAAAA CGCGCCCGCC AAGCAGCCGG CTCAAGTCGA 801 CATCAAAAAAGTAAATTAAThis corresponds to the amino acid sequence <SEQ ID 3062; ORF 576.a>:

a576.pep 1 MNTIFKISAL TLSAALALSA CGKKEAAPAS ASEPAAASSA QGDTSSIGST 51MQQASYAMGV DIGRSLKQMK EQGAEIDLKV FTEAMQAVYD GKEIKMTEEQ 101 AQEVMMKFLQEQQAKAVEKH KADAKANKEK GEAFLKENAA KDGVKTTASG 151 LQYKITKQGE GKQPTKDDIVTVEYEGRLID GTVFDSSKAN GGPVTFPLSQ 201 VILGWTEGVQ LLKEGGEATF YIPSNLAYREQGAGDKIGPN ATLVFDVKLV 251 KIGAPENAPA KQPAQVDIKK VN* m576/a576 99.5%identity in 222 aa overlap                                      10        20        30 m576.pep                              MQQASYAMGVDIGRSLKQMKEQGAEIDLKV                              |||||||||||||||||||||||||||||| a576CGKKEAAPASASEPAAASSAQGDTSSIGSTMQQASYAMGVDIGRSLKQMKEQGAEIDLKV        30        40        50        60        70        80        40        50        60        70        80        90 m576.pepFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKHKADAKANKEKGEAFLKENAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a576FTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKHKADAKANKEKGEAFLKENAA        90       100       110       120       130       140       100       110       120       130       140       150 m576.pepKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLIDGTVFDSSKANGGPVTFPLSQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a576KDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLIDGTVFDSSKANGGPVTFPLSQ       150       160       170       180       190       200       160       170       180       190       200       210 m576.pepVIPGWTEGVQLLKEGGEATFYIPSNLAYREQGAGDKIGPNATLVFDVKLVKIGAPENAPA|| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a576VILGWTEGVQLLKEGGEATFYIPSNLAYREQGAGDKIGPNATLVFDVKLVKIGAPENAPA       210       220       230       240       250       260        220m576.pep KQPAQVDIKKVNX ||||||||||||| a576 KQPAQVDIKKVNX        270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3063>:

m576-1.seq 1 ATGAACACCA TTTTCAAAAT CAGCGCACTG ACCCTTTCCG CCGCTTTGGC 51ACTTTCCGCC TGCGGCAAAA AAGAAGCCGC CCCCGCATCT GCATCCGAAC 101 CTGCCGCCGCTTCTTCCGCG CAGGGCGACA CCTCTTCGAT CGGCAGCACG 151 ATGCAGCAGG CAAGCTATGCGATGGGCGTG GACATCGGAC GCTCCCTGAA 201 GCAAATGAAG GAACAGGGCG CGGAAATCGATTTGAAAGTC TTTACCGAAG 251 CCATGCAGGC AGTGTATGAC GGCAAAGAAA TCAAAATGACCGAAGAGCAG 301 GCTCAGGAAG TCATGATGAA ATTCCTTCAG GAACAACAGG CTAAAGCCGT351 AGAAAAACAC AAGGCGGACG CGAAGGCCAA TAAAGAAAAA GGCGAAGCCT 401TTCTGAAAGA AAATGCCGCC AAAGACGGCG TGAAGACCAC TGCTTCCGGC 451 CTGCAATACAAAATCACCAA ACAGGGCGAA GGCAAACAGC CGACCAAAGA 501 CGACATCGTT ACCGTGGAATACGAAGGCCG CCTGATTGAC GGTACGGTAT 551 TCGACAGCAG CAAAGCCAAC GGCGGCCCGGTCACCTTCCC TTTGAGCCAA 601 GTGATTCCGG GTTGGACCGA AGGCGTACAG CTTCTGAAAGAAGGCGGCGA 651 AGCCACGTTC TACATCCCGT CCAACCTTGC CTACCGCGAA CAGGGTGCGG701 GCGACAAAAT CGGTCCGAAC GCCACTTTGG TATTTGATGT GAAACTGGTC 751AAAATCGGCG CACCCGAAAA CGCGCCCGCC AAGCAGCCGG CTCAAGTCGA 801 CATCAAAAAAGTAAATTAAThis corresponds to the amino acid sequence <SEQ ID 3064; ORF 576-1>:

m576-1.pep 1 MNTIFKISAL TLSAALALSA CGKKEAAPAS ASEPAAASSA QGDTSSIGST 51MQQASYAMGV DIGRSLKQMK EQGAEIDLKV FTEAMQAVYD GKEIKMTEEQ 101 AQEVMMKFLQEQQAKAVEKH KADAKANKEK GEAFLKENAA KDGVKTTASG 151 LQYKITKQGE GKQPTKDDIVTVEYEGRLID GTVFDSSKAN GGPVTFPLSQ 201 VIPGWTEGVQ LLKEGGEATF YIPSNLAYREQGAGDKIGPN ATLVFDVKLV 251 KIGAPENAPA KQPAQVDIKK VN*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3065>:

g576-1.seq 1 ATGAACACCA TTTTCAAAAT CAGCGCACTG ACCCTTTCCG CCGCTTTGGC 51ACTTTCCGCC TGCGGCAAAA AAGAAGCCGC CCCCGCATCT GCATCCGAAC 101 CTGCCGCCGCTTCTGCCGCG CAGGGCGACA CCTCTTCAAT CGGCAGCACG 151 ATGCAGCAGG CAAGCTATGCAATGGGCGTG GACATCGGAC GCTCCCTGAA 201 ACAAATGAAG GAACAGGGCG CGGAAATCGATTTGAAAGTC TTTACCGATG 251 CCATGCAGGC AGTGTATGAC GGCAAAGAAA TCAAAATGACCGAAGAGCAG 301 GCCCAGGAAG TGATGATGAA ATTCCTGCAG GAGCAGCAGG CTAAAGCCGT351 AGAAAAACAC AAGGCGGATG CGAAGGCCAA CAAAGAAAAA GGCGAAGCCT 401TCCTGAAGGA AAATGCCGCC AAAGACGGCG TGAAGACCAC TGCTTCCGGT 451 CTGCAGTACAAAATCACCAA ACAGGGTGAA GGCAAACAGC CGACAAAAGA 501 CGACATCGTT ACCGTGGAATACGAAGGCCG CCTGATTGAC GGTACCGTAT 551 TCGACAGCAG CAAAGCCAAC GGCGGCCCGGCCACCTTCCC TTTGAGCCAA 601 GTGATTCCGG GTTGGACCGA AGGCGTACGG CTTCTGAAAGAAGGCGGCGA 651 AGCCACGTTC TACATCCCGT CCAACCTTGC CTACCGCGAA CAGGGTGCGG701 GCGAAAAAAT CGGTCCGAAC GCCACTTTGG TATTTGACGT GAAACTGGTC 751AAAATCGGCG CACCCGAAAA CGCGCCCGCC AAGCAGCCGG ATCAAGTCGA 801 CATCAAAAAAGTAAATTAAThis corresponds to the amino acid sequence <SEQ ID 3066; ORF 576-1.ng>:

g576-1.pep 1 MNTIFKISAL TLSAALALSA CGKKEAAPAS ASEPAAASAA QGDTSSIGST 51MQQASYAMGV DIGRSLKQMK EQGAEIDLKV FTDAMQAVYD GKEIKMTEEQ 101 AQEVMMKFLQEQQAKAVEKH KADAKANKEK GEAFLKENAA KDGVKTTASG 151 LQYKITKQGE GKQPTKDDIVTVEYEGRLID GTVFDSSKAN GGPATFPLSQ 201 VIPGWTEGVR LLKEGGEATF YIPSNLAYREQGAGEKIGPN ATLVFDVKLV 251 KIGAPENAPA KQPDQVDIKK VN* g576-1/m576-1 ORFa576-1 and 567-1.a showed a 97.8% identity in 272 aa overlap        10        20        30        40        50        60 g576-1.pepMNTIFKISALTLSAALALSACGKKEAAPASASEPAAASAAQGDTSSIGSTMQQASYAMGV||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||| m576-1MNTIFKISALTLSAALALSACGKKEAAPASASEPAAASSAQGDTSSIGSTMQQASYAMGV        10        20        30        40        50        60        70        80        90       100       110       120 g576-1.pepDIGRSLKQMKEQGAEIDLKVFTDAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKH||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||| m576-1DIGRSLKQMKEQGAEIDLKVFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKH        70        80        90       100       110       120       130       140       150       160       170       180 g576-1.pepKADAKANKEKGEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLID|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m576-1KADAKANKEKGEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLID       130       140       150       160       170       180       190       200       210       220       230       240 g576-1.pepGTVFDSSKANGGPATFPLSQVIPGWTEGVRLLKEGGEATFYIPSNLAYREQGAGEKIGPN|||||||||||||:|||||||||||||||:||||||||||||||||||||||||:||||| m576-1GTVFDSSKANGGPVTFPLSQVIPGWTEGVQLLKEGGEATFYIPSNLAYREQGAGDKIGPN       190       200       210       220       230       240       250       260       270 g576-1.pepATLVFDVKLVKIGAPENAPAKQPDQVDIKKVNX ||||||||||||||||||||||| |||||||||m576-1 ATLVFDVKLVKIGAPENAPAKQPAQVDIKKVNX        250       260       270The following DNA sequence was identified in N. meningitidis <SEQ ID3067>:

a576-1.seq 1 ATGAACACCA TTTTCAAAAT CAGCGCACTG ACCCTTTCCG CCGCTTTGGC 51ACTTTCCGCC TGCGGCAAAA AAGAAGCCGC CCCCGCATCT GCATCCGAAC 101 CTGCCGCCGCTTCTTCCGCG CAGGGCGACA CCTCTTCGAT CGGCAGCACG 151 ATGCAGCAGG CAAGCTATGCGATGGGCGTG GACATCGGAC GCTCCCTGAA 201 GCAAATGAAG GAACAGGGCG CGGAAATCGATTTGAAAGTC TTTACCGAAG 251 CCATGCAGGC AGTGTATGAC GGCAAAGAAA TCAAAATGACCGAAGAGCAG 301 GCTCAGGAAG TCATGATGAA ATTCCTTCAG GAACAACAGG CTAAAGCCGT351 AGAAAAACAC AAGGCGGACG CGAAGGCCAA TAAAGAAAAA GGCGAAGCCT 401TTCTGAAAGA AAATGCCGCC AAAGACGGCG TGAAGACCAC TGCTTCCGGC 451 CTGCAATACAAAATCACCAA ACAGGGCGAA GGCAAACAGC CGACCAAAGA 501 CGACATCGTT ACCGTGGAATACGAAGGCCG CCTGATTGAC GGTACGGTAT 551 TCGACAGCAG CAAAGCCAAC GGCGGCCCGGTCACCTTCCC TTTGAGCCAA 601 GTGATTCTGG GTTGGACCGA AGGCGTACAG CTTCTGAAAGAAGGCGGCGA 651 AGCCACGTTC TACATCCCGT CCAACCTTGC CTACCGCGAA CAGGGTGCGG701 GCGACAAAAT CGGCCCGAAC GCCACTTTGG TATTTGATGT GAAACTGGTC 751AAAATCGGCG CACCCGAAAA CGCGCCCGCC AAGCAGCCGG CTCAAGTCGA 801 CATCAAAAAAGTAAATTAAThis corresponds to the amino acid sequence <SEQ ID 3068; ORF 576-1.a>:

a576-1.pep 1 MNTIFKISAL TLSAALALSA CGKKEAAPAS ASEPAAASSA QGDTSSIGST 51MQQASYAMGV DIGRSLKQMK EQGAEIDLKV FTEAMQAVYD GKEIKMTEEQ 101 AQEVMMKFLQEQQAKAVEKH KADAKANKEK GEAFLKENAA KDGVKTTASG 151 LQYKITKQGE GKQPTKDDIVTVEYEGRLID GTVFDSSKAN GGPVTFPLSQ 201 VILGWTEGVQ LLKEGGEATF YIPSNLAYREQGAGDKIGPN ATLVFDVKLV 251 KIGAPENAPA KQPAQVDIKK VN* a576-1/m576-1 99.6%identity in 272 aa overlap        10        20        30        40        50        60 a576-1.pepMNTIFKISALTLSAALALSACGKKEAAPASASEPAAASSAQGDTSSIGSTMQQASYAMGV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m576-1MNTIFKISALTLSAALALSACGKKEAAPASASEPAAASSAQGDTSSIGSTMQQASYAMGV        10        20        30        40        50        60        70        80        90       100       110       120 a576-1.pepDIGRSLKQMKEQGAEIDLKVFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m576-1DIGRSLKQMKEQGAEIDLKVFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKH        70        80        90       100       110       120       130       140       150       160       170       180 a576-1.pepKADAKANKEKGEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLID|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m576-1KADAKANKEKGEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLID       130       140       150       160       170       180       190       200       210       220       230       240 a576-1.pepGTVFDSSKANGGPVTFPLSQVILGWTEGVQLLKEGGEATFYIPSNLAYREQGAGDKIGPN|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| m576-1GTVFDSSKANGGPVTFPLSQVIPGWTEGVQLLKEGGEATFYIPSNLAYREQGAGDKIGPN       190       200       210       220       230       240       250       260       270 a576-1.pepATLVFDVKLVKIGAPENAPAKQPAQVDIKKVNX |||||||||||||||||||||||||||||||||m576-1 ATLVFDVKLVKIGAPENAPAKQPAQVDIKKVNX        250       260       270919 gnm43.seqThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 3069>:

m919.seq 1 ATGAAAAAAT ACCTATTCCG CGCCGCCCTG TACGGCATCG CCGCCGCCAT 51CCTCGCCGCC TGCCAAAGCA AGAGCATCCA AACCTTTCCG CAACCCGACA 101 CATCCGTCATCAACGGCCCG GACCGGCCGG TCGGCATCCC CGACCCCGCC 151 GGAACGACGG TCGGCGGCGGCGGGGCCGTC TATACCGTTG TACCGCACCT 201 GTCCCTGCCC CACTGGGCGG CGCAGGATTTCGCCAAAAGC CTGCAATCCT 251 TCCGCCTCGG CTGCGCCAAT TTGAAAAACC GCCAAGGCTGGCAGGATGTG 301 TGCGCCCAAG CCTTTCAAAC CCCCGTCCAT TCCTTTCAGG CAAAACAGTT351 TTTTGAACGC TATTTCACGC CGTGGCAGGT TGCAGGCAAC GGAAGCCTTG 401CCGGTACGGT TACCGGCTAT TACGAACCGG TGCTGAAGGG CGACGACAGG 451 CGGACGGCACAAGCCCGCTT CCCGATTTAC GGTATTCCCG ACGATTTTAT 501 CTCCGTCCCC CTGCCTGCCGGTTTGCGGAG CGGAAAAGCC CTTGTCCGCA 551 TCAGGCAGAC GGGAAAAAAC AGCGGCACAATCGACAATAC CGGCGGCACA 601 CATACCGCCG ACCTCTCCcG ATTCCCCATC ACCGCGCGCACAACAGCAAT 651 CAAAGGCAGG TTTGAAGGAA GCCGCTTCCT CCCCTACCAC ACGCGCAACC701 AAATCAACGG CGGCGCGCTT GACGGCAAAG CCCCGATACT CGGTTACGCC 751GAAGACCCTG TCGAACTTTT TTTTATGCAC ATCCAAGGCT CGGGCCGTCT 801 GAAAACCCCGTCCGGCAAAT ACATCCGCAT CGGCTATGCC GACAAAAACG 851 AACATCCyTA CGTTTCCATCGGACGCTATA TGGCGGATAA GGGCTACCTC 901 AAACTCGGAC AAACCTCCAT GCAGGGCATTAAGTCTTATA TGCGGCAAAA 951 TCCGCAACGC CTCGCCGAAG TTTTGGGTCA AAACCCCAGCTATATCTTTT 1001 TCCGCGAGCT TGCCGGAAGC AGCAATGACG GCCCTGTCGG CGCACTGGGC1051 ACGCCGCTGA TGGGGGAATA TGCCGGCGCA GTCGACCGGC ACTACATTAC 1101CTTGGGTGCG CCCTTATTTG TCGCCACCGC CCATCCGGTT ACCCGCAAAG 1151 CCCTCAACCGCCTGATTATG GCGCAGGATA CCGGCAGCGC GATTAAAGGC 1201 GCGGTGCGCG TGGATTATTTTTGGGGATAC GGCGACGAAG CCGGCGAACT 1251 TGCCGGCAAA CAGAAAACCA CGGGATATGTCTGGCAGCTC CTACCCAACG 1301 GTATGAAGCC CGAATACCGc CCGTAAThis corresponds to the amino acid sequence <SEQ ID 3070; ORF 919>:

m919.pep 1 MKKYLFRAAL YGIAAAILAA CQSKSIQTFP QPDTSVINGP DRPVGIPDPA 51GTTVGGGGAV YTVVPHLSLP HWAAQDFAKS LQSFRLGCAN LKNRQGWQDV 101 CAQAFQTPVHSFQAKQFFER YFTPWQVAGN GSLAGTVTGY YEPVLKGDDR 151 RTAQARFPIY GIPDDFISVPLPAGLRSGKA LVRIRQTGKN SGTIDNTGGT 201 HTADLSRFPI TARTTAIKGR FEGSRFLPYHTRNQINGGAL DGKAPILGYA 251 EDPVELFFMH IQGSGRLKTP SGKYIRIGYA DKNEHPYVSIGRYMADKGYL 301 KLGQTSMQGI KSYMRQNPQR LAEVLGQNPS YIFFRELAGS SNDGPVGALG351 TPLMGEYAGA VDRHYITLGA PLFVATAHPV TRKALNRLIM AQDTGSAIKG 401AVRVDYFWGY GDEAGELAGK QKTTGYVWQL LPNGMKPEYR P*The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 3071>:

g919.seq 1 ATGAAAAAAC ACCTGCTCCG CTCCGCCCTG TACGGcatCG CCGCCgccAT 51CctcgCCGCC TGCCAAAgca gGAGCATCCA AACCTTTCCG CAACCCGACA 101 CATCCGTCATCAACGGCCCG GACCGGCCGG CCGGCATCCC CGACCCCGCC 151 GGAACGACGG TTGCCGGCGGCGGGGCCGTC TATACCGTTG TGCCGCACCT 201 GTCCATGCCC CACTGGGCGG CGCaggATTTTGCCAAAAGC CTGCAATCCT 251 TCCGCCTCGG CTGCGCCAAT TTGAAAAACC GCCAAGGCTGGCAGGATGTG 301 TGCGCCCAAG CCTTTCAAAC CCCCGTGCAT TCCTTTCAGG CAAAGcGgTT351 TTTTGAACGC TATTTCACGC cgtGGCaggt tgcaggcaAC GGAAGcCTTG 401Caggtacggt TACCGGCTAT TACGAACCGG TGCTGAAGGG CGACGGCAGG 451 CGGACGGAACGGGCCCGCTT CCCGATTTAC GGTATTCCCG ACGATTTTAT 501 CTCCGTCCCG CTGCCTGCCGGTTTGCGGGG CGGAAAAAAC CTTGTCCGCA 551 TCAGGCAGac ggGGAAAAAC AGCGGCACGATCGACAATGC CGGCGGCACG 601 CATACCGCCG ACCTCTCCCG ATTCCCCATC ACCGCGCGCACAACGGcaat 651 caaaGGCAGG TTTGAaggAA GCCGCTTCCT CCCTTACCAC ACGCGCAACC701 AAAtcaacGG CGGCgcgcTT GACGGCAAag cccCCATCCT CggttacgcC 751GAagaccCcG tcgaacttTT TTTCATGCAC AtccaaggCT CGGGCCGCCT 801 GAAAACCCcgtccggcaaat acatCCGCAt cggaTacgcc gacAAAAACG 851 AACAtccgTa tgtttccatcggACGctaTA TGGCGGACAA AGGCTACCTC 901 AAGctcgggc agACCTCGAT GCAGGgcatcaaagcCTATA TGCGGCAAAA 951 TCCGCAACGC CTCGCCGAAG TTTTGGGTCA AAACCCCAGCTATATCTTTT 1001 TCCGCGAGCT TGCCGGAAGC GGCAATGAGG GCCCCGTCGG CGCACTGGGC1051 ACGCCACTGA TGGGGGAATA CGCCGGCGCA ATCGACCGGC ACTACATTAC 1101CTTGGGCGCG CCCTTATTTG TCGCCACCGC CCATCCGGTT ACCCGCAAAG 1151 CCCTCAACCGCCTGATTATG GCGCAGGATA CAGGCAGCGC GATCAAAGGC 1201 GCGGTGCGCG TGGATTATTTTTGGGGTTAC GGCGACGAAG CCGGCGAACT 1251 TGCCGGCAAA CAGAAAACCA CGGGATACGTCTGGCAGCTC CTGCCCAACG 1301 GCATGAAGCC CGAATACCGC CCGTGAThis corresponds to the amino acid sequence <SEQ ID 3072; ORF 919.ng>:

g919.pep 1 MKKHLLRSAL YGIAAAILAA CQSRSIQTFP QPDTSVINGP DRPAGIPDPA 51GTTVAGGGAV YTVVPHLSMP HWAAQDFAKS LQSFRLGCAN LKNRQGWQDV 101 CAQAFQTPVHSFQAKRFFER YFTPWQVAGN GSLAGTVTGY YEPVLKGDGR 151 RTERARFPIY GIPDDFISVPLPAGLRGGKN LVRIRQTGKN SGTIDNAGGT 201 HTADLSRFPI TARTTAIKGR FEGSRFLPYHTRNQINGGAL DGKAPILGYA 251 EDPVELFFMH IQGSGRLKTP SGKYIRIGYA DKNEHPYVSIGRYMADKGYL 301 KLGQTSMQGI KAYMRQNPQR LAEVLGQNPS YIFFRELAGS GNEGPVGALG351 TPLMGEYAGA IDRHYITLGA PLFVATAHPV TRKALNRLIM AQDTGSAIKG 401AVRVDYFWGY GDEAGELAGK QKTTGYVWQL LPNGMKPEYR P*ORF 919 shows 95.9% identity over a 441 aa overlap with a predicted ORF(ORF 919.ng) from N. gonorrhoeae:

m919/g919         10        20        30        40        50        60m919.pep MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAV|||:|:|:|||||||||||||||:|||||||||||||||||||:||||||||||:||||| g919MKKHLLRSALYGIAAAILAACQSRSIQTFPQPDTSVINGPDRPAGIPDPAGTIVAGGGAV        10        20        30        40        50        60        70        80        90       100       110       120 m919.pepYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFER||||||||:||||||||||||||||||||||||||||||||||||||||||||||:|||| g919YTVVPHLSMPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKRFFER        70        80        90       100       110       120       130       140       150       160       170       180 m919.pepYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKA|||||||||||||||||||||||||||| ||| :||||||||||||||||||||||:|| g919YFTPWQVAGNGSLAGTVTGYYEPVLKGDGRRTERARFPIYGIPDDFISVPLPAGLRGGKN       130       140       150       160       170       180       190       200       210       220       230       240 m919.pepLVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGAL||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||| g919LVRIRQTGKNSGTIDNAGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGAL       190       200       210       220       230       240       250       260       270       280       290       300 m919.pepDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g919DGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYL       250       260       270       280       290       300       310       320       330       340       350       360 m919.pepKLGQISMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGA|||||||||||:||||||||||||||||||||||||||||:|:||||||||||||||||| g919KLGQISMQGIKAYMRQNPQRLAEVLGQNPSYIFFRELAGSGNEGPVGALGTPLMGEYAGA       310       320       330       340       350       360       370       380       390       400       410       420 m919.pepVDRHYITLGAPLFVATAHPVIRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGK:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g919IDRHYITLGAPLFVATAHPVIRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGK       370       380       390       400       410       420       430       440 m919.pep QKTTGYVWQLLPNGMKPEYRPX|||||||||||||||||||||| g919 QKTTGYVWQLLPNGMKPEYRPX        430       440The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3073>:

a919.seq 1 ATGAAAAAAT ACCTATTCCG CGCCGCCCTG TGCGGCATCG CCGCCGCCAT 51CCTCGCCGCC TGCCAAAGCA AGAGCATCCA AACCTTTCCG CAACCCGACA 101 CATCCGTCATCAACGGCCCG GACCGGCCGG TCGGCATCCC CGACCCCGCC 151 GGAACGACGG TCGGCGGCGGCGGGGCCGTT TATACCGTTG TGCCGCACCT 201 GTCCCTGCCC CACTGGGCGG CGCAGGATTTCGCCAAAAGC CTGCAATCCT 251 TCCGCCTCGG CTGCGCCAAT TTGAAAAACC GCCAAGGCTGGCAGGATGTG 301 TGCGCCCAAG CCTTTCAAAC CCCCGTCCAT TCCGTTCAGG CAAAACAGTT351 TTTTGAACGC TATTTCACGC CGTGGCAGGT TGCAGGCAAC GGAAGCCTTG 401CCGGTACGGT TACCGGCTAT TACGAGCCGG TGCTGAAGGG CGACGACAGG 451 CGGACGGCACAAGCCCGCTT CCCGATTTAC GGTATTCCCG ACGATTTTAT 501 CTCCGTCCCC CTGCCTGCCGGTTTGCGGAG CGGAAAAGCC CTTGTCCGCA 551 TCAGGCAGAC GGGAAAAAAC AGCGGCACAATCGACAATAC CGGCGGCACA 601 CATACCGCCG ACCTCTCCCA ATTCCCCATC ACTGCGCGCACAACGGCAAT 651 CAAAGGCAGG TTTGAAGGAA GCCGCTTCCT CCCCTACCAC ACGCGCAACC701 AAATCAACGG CGGCGCGCTT GACGGCAAAG CCCCGATACT CGGTTACGCC 751GAAGACCCCG TCGAACTTTT TTTTATGCAC ATCCAAGGCT CGGGCCGTCT 801 GAAAACCCCGTCCGGCAAAT ACATCCGCAT CGGCTATGCC GACAAAAACG 851 AACATCCCTA CGTTTCCATCGGACGCTATA TGGCGGACAA AGGCTACCTC 901 AAGCTCGGGC AGACCTCGAT GCAGGGCATCAAAGCCTATA TGCAGCAAAA 951 CCCGCAACGC CTCGCCGAAG TTTTGGGGCA AAACCCCAGCTATATCTTTT 1001 TCCGAGAGCT TACCGGAAGC AGCAATGACG GCCCTGTCGG CGCACTGGGC1051 ACGCCGCTGA TGGGCGAGTA CGCCGGCGCA GTCGACCGGC ACTACATTAC 1101CTTGGGCGCG CCCTTATTTG TCGCCACCGC CCATCCGGTT ACCCGCAAAG 1151 CCCTCAACCGCCTGATTATG GCGCAGGATA CCGGCAGCGC GATTAAAGGC 1201 GCGGTGCGCG TGGATTATTTTTGGGGATAC GGCGACGAAG CCGGCGAACT 1251 TGCCGGCAAA CAGAAAACCA CGGGATATGTCTGGCAGCTT CTGCCCAACG 1301 GTATGAAGCC CGAATACCGC CCGTAAThis corresponds to the amino acid sequence <SEQ ID 3074; ORF 919.a>:

a919.pep 1 MKKYLFRAAL CGIAAAILAA CQSKSIQTFP QPDTSVINGP DRPVGIPDPA 51GTTVGGGGAV YTVVPHLSLP HWAAQDFAKS LQSFRLGCAN LKNRQGWQDV 101 CAQAFQTPVHSVQAKQFFER YFTPWQVAGN GSLAGTVTGY YEPVLKGDDR 151 RTAQARFPIY GIPDDFISVPLPAGLRSGKA LVRIRQTGKN SGTIDNTGGT 201 HTADLSQFPI TARTTAIKGR FEGSRFLPYHTRNQINGGAL DGKAPILGYA 251 EDPVELFFMH IQGSGRLKTP SGKYIRIGYA DKNEHPYVSIGRYMADKGYL 301 KLGQTSMQGI KAYMQQNPQR LAEVLGQNPS YIFFRELTGS SNDGPVGALG351 TPLMGEYAGA VDRHYITLGA PLFVATAHPV TRKALNRLIM AQDTGSAIKG 401AVRVDYFWGY GDEAGELAGK QKTTGYVWQL LPNGMKPEYR P* m919/a919 98.6% identityin 441 aa overlap         10        20        30        40        50        60 m919.pep MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAV |||||||||| ||||||||||||||||||||||||||||||||||||||||||||||||| a919 MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAV         10        20        30        40        50        60         70        80        90       100       110       120 m919.pep YTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFER ||||||||||||||||||||||||||||||||||||||||||||||||||| |||||||| a919 YTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSVQAKQFFER         70        80        90       100       110       120        130       140       150       160       170       180 m919.pep YFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKA |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a919 YFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKA        130       140       150       160       170       180        190       200       210       220       230       240 m919.pep LVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGAL ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| a919 LVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGAL        190       200       210       220       230       240        250       260       270       280       290       300 m919.pep DGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYL |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a919 DGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYL        250       260       270       280       290       300        310       320       330       340       350       360 m919.pep KLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGA |||||||||||:||:||||||||||||||||||||||:|||||||||||||||||||||| a919 KLGQTSMQGIKAYMQQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGA        310       320       330       340       350       360        370       380       390       400       410       420 m919.pep VDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGK |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a919 VDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGK        370       380       390       400       410       420        430       440 m919.pep  QKTTGYVWQLLPNGMKPEYRPX |||||||||||||||||||||| a919  QKTTGYVWQLLPNGMKPEYRPX 430      440121 and 121-1The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3075>:

m121.seq 1 ATGGAAACAC AGCTTTACAT CGGCATCATG TCGGGAACCA GCATGGACGG 51GGCGGATGCC GTACTGATAC GGATGGACGG CGGCAAATGG CTGGGCGCGG 101 AAGGGCACGCCTTTACCCCC TACCCCGGCA GGTTACGCCG CCAATTGCTG 151 GATTTGCAGG ACACAGGCGCAGACGAACTG CACCGCAGCA GGATTTTGTC 201 GCAAGAACTC AGCCGCCTAT ATGCGCAAACCGCCGCCGAA CTGCTGTGCA 251 GTCAAAACCT CGCACCGTCC GACATTACCG CCCTCGGCTGCCACGGGCAA 301 ACCGTCCGAC ACGCGCCGGA ACACGGTTAC AGCATACAGC TTGCCGATTT351 GCCGCTGCTG GCGxxxxxxx xxxxxxxxxx xxxxxxxxxx xxxxxxxxxx 401xxxxxxxxxx xxxxxxxxxx xxxxxxxxxx xxxxxxxxxx xxxxxxxxxx 451 xxxxxxxxxxxxxxxxxxxx xxxxxxxxxx xxxxxxxxxx xxxxxxxxxx 501 xxxxxxxxxx xxxxxxxxxxxxxxxxxxxx xxxxxxxxxx xxxxxxxxxx 551 xxxxxxxxxx xxxxxxxxxx xxxxxxxxxxxxxxxxxxxx xxxxxxxxxx 601 xxxxxxCAGC TTCCTTACGA CAAAAACGGT GCAAAGTCGGCACAAGGCAA 651 CATATTGCCG CAACTGCTCG ACAGGCTGCT CGCCCACCCG TATTTCGCAC701 AACGCCACCC TAAAAGCACG GGGCGCGAAC TGTTTGCCAT AAATTGGCTC 751GAAACCTACC TTGACGGCGG CGAAAACCGA TACGACGTAT TGCGGACGCT 801 TTCCCGTTTTACCGCGCAAA CCGTTTGCGA CGCCGTCTCA CACGCAGCGG 851 CAGATGCCCG TCAAATGTACATTTGCGACG GCGGCATCCG CAATCCTGTT 901 TTAATGGCGG ATTTGGCAGA ATGTTTCGGCACACGCGTTT CCCTGCACAG 951 CACCGCCGAC CTGAACCTCG ATCCGCAATG GGTGGAAGCCGCCGnATTTG 1001 CGTGGTTGGC GGCGTGTTGG ATTAATCGCA TTCCCGGTAG TCCGCACAAA1051 GCAACCGGCG CATCCAAACC GTGTATTCTG AnCGCGGGAT ATTATTATTG 1101 AThis corresponds to the amino acid sequence <SEQ ID 3076; ORF 121>:

m121.pep 1 METQLYIGIM SGTSMDGADA VLIRMDGGKW LGAEGHAFTP YPGRLRRQLL 51DLQDTGADEL HRSRILSQEL SRLYAQTAAE LLCSQNLAPS DITALGCHGQ 101 TVRHAPEHGYSIQLADLPLL Axxxxxxxxx xxxxxxxxxx xxxxxxxxxx 151 xxxxxxxxxx xxxxxxxxxxxxxxxxxxxx xxxxxxxxxx xxxxxxxxxx 201 xxQLPYDKNG AKSAQGNILP QLLDRLLAHPYFAQRHPKST GRELFAINWL 251 ETYLDGGENR YDVLRTLSRF TAQTVCDAVS HAAADARQMYICDGGIRNPV 301 LMADLAECFG TRVSLHSTAD LNLDPQWVEA AXFAWLAACW INRIPGSPHK351 ATGASKPCIL XAGYYY*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3077>:

g121.seq 1 ATGGAAACAC AGCTTTACAT CGGCATTATG TCGGGAACCA GTATGGACGG 51GGCGGATGCC GTGCTGGTAC GGATGGACGG CGGCAAATGG CTGGGCGCGG 101 AAGGGCACGCCTTTACCCCC TACCCTGACC GGTTGCGCCG CAAATTGCTG 151 GATTTGCAGG ACACAGGCACAGACGAACTG CACCGCAGCA GGATGTTGTC 201 GCAAGAACTC AGCCGCCTGT ACGCGCAAACCGCCGCCGAA CTGCTGTGCA 251 GTCAAAACCT CGCTCCGTGC GACATTACCG CCCTCGGCTGCCACGGGCAA 301 ACCGTCCGAC ACGCGCCGGA ACACGGTtac AGCATACAGC TTGCCGATTT351 GCCGCTGCTG GCGGAACTGa cgcggatttT TACCGTCggc gacttcCGCA 401GCCGCGACCT TGCTGCCGGC GGacaAGGTG CGCCGCTCGT CCCCGCCTTT 451 CACGAAGCCCTGTTCCGCGA TGACAGGGAA ACACGCGTGG TACTGAACAT 501 CGGCGGGATT GCCAACATCAGCGTACTCCC CCCCGGCGCA CCCGCCTTCG 551 GCTTCGACAC AGGGCCGGGC AATATGCTGATGGAcgcgtg gacgcaggca 601 cacTGGcagc TGCCTTACGA CAAAAacggt gcAAAGgcggcacAAGGCAA 651 catatTGCcg cAACTGCTCG gcaggctGCT CGCCcaccCG TATTTCTCAC701 AACCCcaccc aaAAAGCACG GGgcGCGaac TgtttgcccT AAattggctc 751gaaacctAcc ttgacggcgg cgaaaaccga tacgacgtat tgcggacgct 801 ttcccgattcaccgcgcaaA ccgTttggga cgccgtctca CACGCAGCGG 851 CAGATGCCCG TCAAATGTACATTTGCGGCG GCGGCATCCG CAATCCTGTT 901 TTAATGGCGG ATTTGGCAGA ATGTTTCGGCACACGCGTTT CCCTGCACAG 951 CACCGCCGAA CTGAACCTCG ATCCTCAATG GGTGGAGGCGgccgCATTtg 1001 cgtggttggC GGCGTGTTGG ATTAACCGCA TTCCCGGTAG TCCGCACAAA1051 GCGACCGGCG CATCCAAACC GTGTATTCTG GGCGCGGGAT ATTATTATTG 1101 AThis corresponds to the amino acid sequence <SEQ ID 3078; ORF 121.ng>:

g121.pep 1 METQLYIGIM SGTSMDGADA VLVRMDGGKW LGAEGHAFTP YPDRLRRKLL 51DLQDTGTDEL HRSRMLSQEL SRLYAQTAAE LLCSQNLAPC DITALGCHGQ 101 TVRHAPEHGYSIQLADLPLL AELTRIFTVG DFRSRDLAAG GQGAPLVPAF 151 HEALFRDDRE TRVVLNIGGIANISVLPPGA PAFGFDTGPG NMLMDAWTQA 201 HWQLPYDKNG AKAAQGNILP QLLGRLLAHPYFSQPHPKST GRELFALNWL 251 ETYLDGGENR YDVLRTLSRF TAQTVWDAVS HAAADARQMYICGGGIRNPV 301 LMADLAECFG TRVSLHSTAE LNLDPQWVEA AAFAWLAACW INRIPGSPHK351 ATGASKPCIL GAGYYY*ORF 121 shows 73.5% identity over a 366 aa overlap with a predicted ORF(ORF121.ng) from N. gonorrhoeae:

m121/g121         10        20        30        40        50        60m121.pep METQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRQLLDLQDTGADEL||||||||||||||||||||||:||||||||||||||||||| ||||:||||||||:||| g121METQLYIGIMSGTSMDGADAVLVRMDGGKWLGAEGHAFTPYPDRLRRKLLDLQDTGTDEL        10        20        30        40        50        60        70        80        90       100       110       120 m121.pepHRSRILSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHGYSIQLADLPLL||||:|||||||||||||||||||||||| |||||||||||||||||||||||||||||| g121HRSRMLSQELSRLYAQTAAELLCSQNLAPCDITALGCHGQTVRHAPEHGYSIQLADLPLL        70        80        90       100       110       120       130       140       150       160       170       180 m121.pepAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX|  :   :                                : g121AELTRIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDDRETRVVLNIGGIANISVLPPGA       130       140       150       160       170       180       190       200       210       220       230       240 m121.pepXXXXXXXXXXXXXXXXXXXXXXQLPYDKNGAKSAQGNILPQLLDRLLAHPYFAQRHPKST      :          :    ||||||||||:|||||||||| ||||||||:| ||||| g121PAFGFDTGPGNMLMDAWTQAHWQLPYDKNGAKAAQGNILPQLLGRLLAHPYFSQPHPKST       190       200       210       220       230       240       250       260       270       280       290       300 m121.pepGRELFAINWLETYLDGGENRYDVLRTLSRFTAQTVCDAVSHAAADARQMYICDGGIRNPV||||||:|||||||||||||||||||||||||||| |||||||||||||||| ||||||| g121GRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVWDAVSHAAADARQMYICGGGIRNPV       250       260       270       280       290       300       310       320       330       340       350       360 m121.pepLMADLAECFGTRVSLHSTADLNLDPQWVEAAXFAWLAACWINRIPGSPHKATGASKPCIL|||||||||||||||||||:||||||||||| |||||||||||||||||||||||||||| g121LMADLAECFGTRVSLHSTAELNLDPQWVEAAAFAWLAACWINRIPGSPHKATGASKPCIL       310       320       330       340       350       360 m121.pepXAGYYYX  |||||| g121 GAGYYYXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 3079>:

a121.seq 1 ATGGAAACAC AGCTTTACAT CGGCATCATG TCGGGAACCA GCATGGACGG 51GGCGGATGCC GTACTGATAC GGATGGACGG CGGCAAATGG CTGGGCGCGG 101 AAGGGCACGCCTTTACCCCC TACCCCGGCA GGTTACGCCG CAAATTGCTG 151 GATTTGCAGG ACACAGGCGCGGACGAACTG CACCGCAGCA GGATGTTGTC 201 GCAAGAACTC AGCCGCCTGT ACGCGCAAACCGCCGCCGAA CTGCTGTGCA 251 GTCAAAACCT CGCGCCGTCC GACATTACCG CCCTCGGCTGCCACGGGCAA 301 ACCGTCAGAC ACGCGCCGGA ACACAGTTAC AGCGTACAGC TTGCCGATTT351 GCCGCTGCTG GCGGAACGGA CTCAGATTTT TACCGTCGGC GACTTCCGCA 401GCCGCGACCT TGCGGCCGGC GGACAAGGCG CGCCGCTCGT CCCCGCCTTT 451 CACGAAGCCCTGTTCCGCGA CGACAGGGAA ACACGCGCGG TACTGAACAT 501 CGGCGGGATT GCCAACATCAGCGTACTCCC CCCCGACGCA CCCGCCTTCG 551 GCTTCGACAC AGGACCGGGC AATATGCTGATGGACGCGTG GATGCAGGCA 601 CACTGGCAGC TTCCTTACGA CAAAAACGGT GCAAAGGCGGCACAAGGCAA 651 CATATTGCCG CAACTGCTCG ACAGGCTGCT CGCCCACCCG TATTTCGCAC701 AACCCCACCC TAAAAGCACG GGGCGCGAAC TGTTTGCCCT AAATTGGCTC 751GAAACCTACC TTGACGGCGG CGAAAACCGA TACGACGTAT TGCGGACGCT 801 TTCCCGATTCACCGCGCAAA CCGTTTTCGA CGCCGTCTCA CACGCAGCGG 851 CAGATGCCCG TCAAATGTACATTTGCGGCG GCGGCATCCG CAATCCTGTT 901 TTAATGGCGG ATTTGGCAGA ATGTTTCGGCACACGCGTTT CCCTGCACAG 951 CACCGCCGAA CTGAACCTCG ATCCGCAATG GGTAGAAGCCGCCGCGTTCG 1001 CATGGATGGC GGCGTGTTGG GTCAACCGCA TTCCCGGTAG TCCGCACAAA1051 GCAACCGGCG CATCCAAACC GTGTATTCTG GGCGCGGGAT ATTATTATTG 1101 AThis corresponds to the amino acid sequence <SEQ ID 3080; ORF 121.a>:

a121.pep 1 METQLYIGIM SGTSMDGADA VLIRMDGGKW LGAEGHAFTP YPGRLRRKLL 51DLQDTGADEL HRSRMLSQEL SRLYAQTAAE LLCSQNLAPS DITALGCHGQ 101 TVRHAPEHSYSVQLADLPLL AERTQIFTVG DFRSRDLAAG GQGAPLVPAF 151 HEALFRDDRE TRAVLNIGGIANISVLPPDA PAFGFDTGPG NMLMDAWMQA 201 HWQLPYDKNG AKAAQGNILP QLLDRLLAHPYFAQPHPKST GRELFALNWL 251 ETYLDGGENR YDVLRTLSRF TAQTVFDAVS HAAADARQMYICGGGIRNPV 301 LMADLAECFG TRVSLHSTAE LNLDPQWVEA AAFAWMAACW VNRIPGSPHK351 ATGASKPCIL GAGYYY* m121/a121 74.0% identity in 366 aa overlap        10        20        30        40        50        60 m121.pepMETQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRQLLDLQDTGADEL|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||| a121METQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRKLLDLQDTGADEL        10        20        30        40        50        60        70        80        90       100       110       120 m121.pepHRSRILSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHGYSIQLADLPLL||||:|||||||||||||||||||||||||||||||||||||||||||:||:|||||||| a121HRSRMLSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHSYSVQLADLPLL        70        80        90       100       110       120       130       140       150       160       170       180 m121.pepAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX|  :   :                                : a121AERTQIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDDRETRAVLNIGGIANISVLPPDA       130       140       150       160       170       180       190       200       210       220       230       240 m121.pepXXXXXXXXXXXXXXXXXXXXXXQLPYDKNGAKSAQGNILPQLLDRLLAHPYFAQRHPKST      :               ||||||||||:||||||||||||||||||||| ||||| a121PAFGFDTGPGNMLMDAWMQAHWQLPYDKNGAKAAQGNILPQLLDRLLAHPYFAQPHPKST       190       200       210       220       230       240       250       260       270       280       290       300 m121.pepGRELFAINWLETYLDGGENRYDVLRTLSRFTAQTVCDAVSHAAADARQMYICDGGIRNPV||||||:|||||||||||||||||||||||||||| |||||||||||||||| ||||||| a121GRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVFDAVSHAAADARQMYICGGGIRNPV       250       260       270       280       290       300       310       320       330       340       350       360 m121.pepLMADLAECFGTRVSLHSTADLNLDPQWVEAAXFAWLAACWINRIPGSPHKATGASKPCIL|||||||||||||||||||:||||||||||| |||:||||:||||||||||||||||||| a121LMADLAECFGTRVSLHSTAELNLDPQWVEAAAFAWMAACWVNRIPGSPHKATGASKPCIL       310       320       330       340       350       360 m121.pepXAGYYYX  |||||| a121 GAGYYYXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 3081>:

m121-1.seq 1 ATGGAAACAC AGCTTTACAT CGGCATCATG TCGGGAACCA GCATGGACGG 51GGCGGATGCC GTACTGATAC GGATGGACGG CGGCAAATGG CTGGGCGCGG 101 AAGGGCACGCCTTTACCCCC TACCCCGGCA GGTTACGCCG CCAATTGCTG 151 GATTTGCAGG ACACAGGCGCAGACGAACTG CACCGCAGCA GGATTTTGTC 201 GCAAGAACTC AGCCGCCTAT ATGCGCAAACCGCCGCCGAA CTGCTGTGCA 251 GTCAAAACCT CGCACCGTCC GACATTACCG CCCTCGGCTGCCACGGGCAA 301 ACCGTCCGAC ACGCGCCGGA ACACGGTTAC AGCATACAGC TTGCCGATTT351 GCCGCTGCTG GCGGAACGGA CGCGGATTTT TACCGTCGGC GACTTCCGCA 401GCCGCGACCT TGCGGCCGGC GGACAAGGCG CGCCACTCGT CCCCGCCTTT 451 CACGAAGCCCTGTTCCGCGA CAACAGGGAA ACACGCGCGG TACTGAACAT 501 CGGCGGGATT GCCAACATCAGCGTACTCCC CCCCGACGCA CCCGCCTTCG 551 GCTTCGACAC AGGGCCGGGC AATATGCTGATGGACGCGTG GACGCAGGCA 601 CACTGGCAGC TTCCTTACGA CAAAAACGGT GCAAAGGCGGCACAAGGCAA 651 CATATTGCCG CAACTGCTCG ACAGGCTGCT CGCCCACCCG TATTTCGCAC701 AACCCCACCC TAAAAGCACG GGGCGCGAAC TGTTTGCCCT AAATTGGCTC 751GAAACCTACC TTGACGGCGG CGAAAACCGA TACGACGTAT TGCGGACGCT 801 TTCCCGTTTTACCGCGCAAA CCGTTTGCGA CGCCGTCTCA CACGCAGCGG 851 CAGATGCCCG TCAAATGTACATTTGCGGCG GCGGCATCCG CAATCCTGTT 901 TTAATGGCGG ATTTGGCAGA ATGTTTCGGCACACGCGTTT CCCTGCACAG 951 CACCGCCGAC CTGAACCTCG ATCCGCAATG GGTGGAAGCCGCCGNATTTG 1001 CGTGGTTGGC GGCGTGTTGG ATTAATCGCA TTCCCGGTAG TCCGCACAAA1051 GCAACCGGCG CATCCAAACC GTGTATTCTG ANCGCGGGAT ATTATTATTG 1101 AThis corresponds to the amino acid sequence <SEQ ID 3082; ORF 121-1>:

m121-1.pep 1 METQLYIGIM SGTSMDGADA VLIRMDGGKW LGAEGHAFTP YPGRLRRQLL 51DLQDTGADEL HRSRILSQEL SRLYAQTAAE LLCSQNLAPS DITALGCHGQ 101 TVRHAPEHGYSIQLADLPLL AERTRIFTVG DFRSRDLAAG GQGAPLVPAF 151 HEALFRDNRE TRAVLNIGGIANISVLPPDA PAFGFDTGPG NMLMDAWTQA 201 HWQLPYDKNG AKAAQGNILP QLLDRLLAHPYFAQPHPKST GRELFALNWL 251 ETYLDGGENR YDVLRTLSRF TAQTVCDAVS HAAADARQMYICGGGIRNPV 301 LMADLAECFG TRVSLHSTAD LNLDPQWVEA AXFAWLAACW INRIPGSPHK351 ATGASKPCIL XAGYYY* m121-1/g121 95.6% identity in 366 aa overlap        10        20        30        40        50        60 m121-1.pepMETQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRQLLDLQDTGADEL||||||||||||||||||||||:||||||||||||||||||| ||||:||||||||:||| g121METQLYIGIMSGTSMDGADAVLVRMDGGKWLGAEGHAFTPYPDRLRRKLLDLQDTGTDEL        10        20        30        40        50        60        70        80        90       100       110       120 m121-1.pepHRSRILSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHGYSIQLADLPLL||||:|||||||||||||||||||||||| |||||||||||||||||||||||||||||| g121HRSRMLSQELSRLYAQTAAELLCSQNLAPCDITALGCHGQTVRHAPEHGYSIQLADLPLL        70        80        90       100       110       120       130       140       150       160       170       180 m121-1.pepAERTRIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDNRETRAVLNIGGIANISVLPPDA|| ||||||||||||||||||||||||||||||||||:||||:||||||||||||||| | g121AELTRIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDDRETRVVLNIGGIANISVLPPGA       130       140       150       160       170       180       190       200       210       220       230       240 m121-1.pepPAFGFDTGPGNMLMDAWTQAHWQLPYDKNGAKAAQGNILPQLLDRLLAHPYFAQPHPKST||||||||||||||||||||||||||||||||||||||||||| ||||||||:||||||| g121PAFGFDTGPGNMLMDAWTQAHWQLPYDKNGAKAAQGNILPQLLGRLLAHPYFSQPHPKST       190       200       210       220       230       240       250       260       270       280       290       300 m121-1.pepGRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVCDAVSHAAADARQMYICGGGIRNPV||||||||||||||||||||||||||||||||||| |||||||||||||||||||||||| g121GRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVWDAVSHAAADARQMYICGGGIRNPV       250       260       270       280       290       300       310       320       330       340       350       360 m121-1.pepLMADLAECFGTRVSLHSTADLNLDPQWVEAAXFAWLAACWINRIPGSPHKATGASKPCIL|||||||||||||||||||:||||||||||| |||||||||||||||||||||||||||| g121LMADLAECFGTRVSLHSTAELNLDPQWVEAAAFAWLAACWINRIPGSPHKATGASKPCIL       310       320       330       340       350       360 m121-1.pepXAGYYYX  |||||| g121 GAGYYYXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 3083>:

a121-1.seq 1 ATGGAAACAC AGCTTTACAT CGGCATCATG TCGGGAACCA GCATGGACGG 51GGCGGATGCC GTACTGATAC GGATGGACGG CGGCAAATGG CTGGGCGCGG 101 AAGGGCACGCCTTTACCCCC TACCCCGGCA GGTTACGCCG CAAATTGCTG 151 GATTTGCAGG ACACAGGCGCGGACGAACTG CACCGCAGCA GGATGTTGTC 201 GCAAGAACTC AGCCGCCTGT ACGCGCAAACCGCCGCCGAA CTGCTGTGCA 251 GTCAAAACCT CGCGCCGTCC GACATTACCG CCCTCGGCTGCCACGGGCAA 301 ACCGTCAGAC ACGCGCCGGA ACACAGTTAC AGCGTACAGC TTGCCGATTT351 GCCGCTGCTG GCGGAACGGA CTCAGATTTT TACCGTCGGC GACTTCCGCA 401GCCGCGACCT TGCGGCCGGC GGACAAGGCG CGCCGCTCGT CCCCGCCTTT 451 CACGAAGCCCTGTTCCGCGA CGACAGGGAA ACACGCGCGG TACTGAACAT 501 CGGCGGGATT GCCAACATCAGCGTACTCCC CCCCGACGCA CCCGCCTTCG 551 GCTTCGACAC AGGACCGGGC AATATGCTGATGGACGCGTG GATGCAGGCA 601 CACTGGCAGC TTCCTTACGA CAAAAACGGT GCAAAGGCGGCACAAGGCAA 651 CATATTGCCG CAACTGCTCG ACAGGCTGCT CGCCCACCCG TATTTCGCAC701 AACCCCACCC TAAAAGCACG GGGCGCGAAC TGTTTGCCCT AAATTGGCTC 751GAAACCTACC TTGACGGCGG CGAAAACCGA TACGACGTAT TGCGGACGCT 801 TTCCCGATTCACCGCGCAAA CCGTTTTCGA CGCCGTCTCA CACGCAGCGG 851 CAGATGCCCG TCAAATGTACATTTGCGGCG GCGGCATCCG CAATCCTGTT 901 TTAATGGCGG ATTTGGCAGA ATGTTTCGGCACACGCGTTT CCCTGCACAG 951 CACCGCCGAA CTGAACCTCG ATCCGCAATG GGTAGAAGCCGCCGCGTTCG 1001 CATGGATGGC GGCGTGTTGG GTCAACCGCA TTCCCGGTAG TCCGCACAAA1051 GCAACCGGCG CATCCAAACC GTGTATTCTG GGCGCGGGAT ATTATTATTG 1101 AThis corresponds to the amino acid sequence <SEQ ID 3084; ORF 121-1.a>:

a121-1.pep 1 METQLYIGIM SGTSMDGADA VLIRMDGGKW LGAEGHAFTP YPGRLRRKLL 51DLQDTGADEL HRSRMLSQEL SRLYAQTAAE LLCSQNLAPS DITALGCHGQ 101 TVRHAPEHSYSVQLADLPLL AERTQIFTVG DFRSRDLAAG GQGAPLVPAF 151 HEALFRDDRE TRAVLNIGGIANISVLPPDA PAFGFDTGPG NMLMDAWMQA 201 HWQLPYDKNG AKAAQGNILP QLLDRLLAHPYFAQPHPKST GRELFALNWL 251 ETYLDGGENR YDVLRTLSRF TAQTVFDAVS HAAADARQMYICGGGIRNPV 301 LMADLAECFG TRVSLHSTAE LNLDPQWVEA AAFAWMAACW VNRIPGSPHK351 ATGASKPCIL GAGYYY* m121-1/a121-1 96.4% identity in 366 aa overlap        10        20        30        40        50        60 m121-1.pepMETQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRQLLDLQDTGADEL|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||| a121-1METQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRKLLDLQDTGADEL        10        20        30        40        50        60        70        80        90       100       110       120 m121-1.pepHRSRILSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHGYSIQLADLPLL||||:|||||||||||||||||||||||||||||||||||||||||||:||:|||||||| a121-1HRSRMLSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHSYSVQLADLPLL        70        80        90       100       110       120       130       140       150       160       170       180 m121-1.pepAERTRIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDNRETRAVLNIGGIANISVLPPDA||||:||||||||||||||||||||||||||||||||:|||||||||||||||||||||| a121-1AERTQIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDDRETRAVLNIGGIANISVLPPDA       130       140       150       160       170       180       190       200       210       220       230       240 m121-1.pepPAFGFDTGPGNMLMDAWTQAHWQLPYDKNGAKAAQGNILPQLLDRLLAHPYFAQPHPKST||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||| a121-1PAFGFDTGPGNMLMDAWMQAHWQLPYDKNGAKAAQGNILPQLLDRLLAHPYFAQPHPKST       190       200       210       220       230       240       250       260       270       280       290       300 m121-1.pepGRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVCDAVSHAAADARQMYICGGGIRNPV||||||||||||||||||||||||||||||||||| |||||||||||||||||||||||| a121-1GRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVFDAVSHAAADARQMYICGGGIRNPV       250       260       270       280       290       300       310       320       330       340       350       360 m121-1.pepLMADLAECFGTRVSLHSTADLNLDPQWVEAAXFAWLAACWINRIPGSPHKATGASKPCIL|||||||||||||||||||:||||||||||| |||:||||:||||||||||||||||||| a121LMADLAECFGTRVSLHSTAELNLDPQWVEAAAFAWMAACWVNRIPGSPHKATGASKPCIL       310       320       330       340       350       360 m121-1.pepXAGYYYX  |||||| a121 GAGYYYX128 and 128-1The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3085>:

m128.seq (partial) 1ATGACTGACA ACGCACTGCT CCATTTGGGC GAAGAACCCC GTTTTGATCA 51AATCAAAACC GAAGACATCA AACCCGCCCT GCAAACCGCC ATCGCCGAAG 101CGCGCGAACA AATCGCCGCC ATCAAAGCCC AAACGCACAC CGGCTGGGCA 151AACACTGTCG AACCCCTGAC CGGCATCACC GAACGCGTCG GCAGGATTTG 201GGGCGTGGTG TCGCACCTCA ACTGCGTCGC CGACACGCCC GAACTGCGCG 251CCGTCTATAA CGAACTGATG CCCGAAATCA CCGTCTTCTT CACCGAAATC 301GGACAAGACA TCGAGCTGTA CAACCGCTTC AAAACCATCA AAAATTCCCC 351CGAATTCGAC ACCCTCTCCC CCGCACAAAA AACCAAACTC AACCAC 1TACGCCAGCG AAAAACTGCG CGAAGCCAAA TACGCGTTCA GCGAAACCGA 51wGTCAAAAAA TAyTTCCCyG TCGGCAAwGT ATTAAACGGA CTGTTCGCCC 101AAmTCAAAAA ACTmTACGGC ATCGGATTTA CCGAAAAAAC yGTCCCCGTC 151TGGCACAAAG ACGTGCGCTA TTkTGAATTG CAACAAAACG GCGAAmCCAT 201AGGCGGCGTT TATATGGATT TGTACGCACG CGAAGGCAAA CGCGGCGGCG 251CGTGGATGAA CGACTACAAA GGCCGCCGCC GTTTTTCAGA CGGCACGCTG 301CAAyTGCCCA CCGCCTACCT CGTCTGCAAC TTCGCCCCAC CCGTCGGCGG 351CAGGGAAGCC CGCyTGAGCC ACGACGAAAT CCTCATCCTC TTCCACGAAA 401CCGGACACGG GCTGCACCAC CTGCTTACCC AAGTGGACGA ACTGGGCGTA 451TCCGGCATCA ACGGCGTAkA ATGGGACGCG GTCGAACTGC CCAGCCAGTT 501TATGGAAAAT TTCGTTTGGG AATACAATGT CTTGGCACAA mTGTCAGCCC 551ACGAAGAAAC CGGcgTTCCC yTGCCGAAAG AACTCTTsGA CAAAwTGCTC 601GCCGCCAAAA ACTTCCAAsG CGGCATGTTC yTsGTCCGGC AAwTGGAGTT 651CGCCCTCTTT GATATGATGA TTTACAGCGA AGACGACGAA GGCCGTCTGA 701AAAACTGGCA ACAGGTTTTA GACAGCGTGC GCAAAAAAGT CGCCGTCATC 751CAGCCGCCCG AATACAACCG CTTCGCCTTG AGCTTCGGCC ACATCTTCGC 801AGGCGGCTAT TCCGCAGCTn ATTACAGCTA CGCGTGGGCG GAAGTATTGA 851GCGCGGACGC ATACGCCGCC TTTGAAGAAA GCGACGATGT CGCCGCCACA 901GGCAAACGCT TTTGGCAGGA AATCCTCGCC GTCGGGGnAT CGCGCAGCGG 951nGCAGAATCC TTCAAAGCCT TCCGCGGCCG CGAACCGAGC ATAGACGCAC 1001TCTTGCGCCA CAGCGGTTTC GACAACGCGG TCTGAThis corresponds to the amino acid sequence <SEQ ID 3086; ORF 128>:

m128.pep (partial) 1MTDNALLHLG EEPRFDQIKT EDIKPALQTA IAEAREQIAA IKAQTHTGWA  51NTVEPLTGIT ERVGRIWGVV SHLNCVADTP ELRAVYNELM PEITVFFTEI 101GQDIELYNRF KTIKNSPEFD TLSPAQKTKL NH // 1YASEKLREAK YAFSETXVKK YFPVGXVLNG LFAQXKKLYG IGFTEKTVPV 51WHKDVRYXEL QQNGEXIGGV YMDLYAREGK RGGAWMNDYK GRRRFSDGTL 101QLPTAYLVCN FAPPVGGREA RLSHDEILIL FHETGHGLHH LLTQVDELGV 151SGINGVXWDA VELPSQFMEN FVWEYNVLAQ XSAHEETGVP LPKELXDKXL 201AAKNFQXGMF XVRQXEFALF DMMIYSEDDE GRLKNWQQVL DSVRKKVAVI 251QPPEYNRFAL SFGHIFAGGY SAAXYSYAWA EVLSADAYAA FEESDDVAAT 301GKRFWQEILA VGXSRSGAES FKAFRGREPS IDALLRHSGF DNAV*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3087>:

g128.seq 1 atgattgaca acgCActgct ccacttgggc gaagaaccCC GTTTTaatca 51aatccaaacc gaagACAtca AACCCGCCGT CCAAACCGCC ATCGCCGAAG 101CGCGCGGACA AATCGCCGCC GTCAAAGCGC AAACGCACAC CGGCTGGGCG 151AACACCGTCG AGCGTCTGAC CGGCATCACC GAACGCGTCG GCAGGATTTG 201GGGCGTCGTG TCCCATCTCA ACTCCGTCGT CGACACGCCC GAACTGCGCG 251CCGTCTATAA CGAACTGATG CCTGAAATCA CCGTCTTCTT CACCGAAATC 301GGACAAGACA TCGAACTGTA CAACCGCTTC AAAACCATCA AAAATTCCCC 351CGAATTTGCA ACGCTTTCCC CCGCACAAAA AACCAAGCTC GATCACGACC 401TGCGCGATTT CGTATTGAGC GGCGCGGAAC TGCCGCCCGA ACGGCAGGCA 451GAACTGGCAA AACTGCAAAC CGAAGGCGCG CAACTTTCCG CCAAATTCTC 501CCAAAACGTC CTAGACGCGA CCGACGCGTT CGGCATTTAC TTTGACGATG 551CCGCACCGCT TGCCGGCATT CCCGAAGACG CGCTCGCCAT GTTTGCCGCC 601GCCGCGCAAA GCGAAGGCAA AACAGGTTAC AAAATCGGCT TGCAGATTCC 651GCACTACCTT GCCGTTATCC AATACGCCGG CAACCGCGAA CTGCGCGAAC 701AAATCTACCG CGCCTACGTT ACCCGTGCCA GCGAACTTTC AAACGACGGC 751AAATTCGACA ACACCGCCAA CATCGACCGC ACGCTCGAAA ACGCATTGAA 801AACCGccaaa cTGCTCGGCT TTAAAAATTA CGCCGAATTG TCGCTGGCAA 851CCAAAATGGC GGACACGCCC GAACAGGTTT TAAACTTCCT GCACGACCTC 901GCCCGCCGCG CCAAACCCTA CGCCGAAAAA GACCTCGCCG AAGTCAAAGC 951CTTCGCCCGC GAACACCTCG GTCTCGCCGA CCCGCAGCCG TGGGACTTGA 1001GCTACGCCGG CGAAAAACTG CGCGAAGCCA AATACGCATT CAGCGAAACC 1051GAAGTCAAAA AATACTTCCC CGTCGGCAAA GTTCTGGCAG GCCTGTTCGC 1101CCAAATCAAA AAACTCTACG GCATCGGATT CGCCGAAAAA ACCGTTCCCG 1151TCTGGCACAA AGACGTGCGC TATTTTGAAT TGCAACAAAA CGGCAAAACC 1201ATCGGCGGCG TTTATATGGA TTTGTACGCA CGCGAAGGCA AACGCGGCGG 1251CGCGTGGATG AACGACtaca AAGGCCGCCG CCGCTTTGCC GACGgcacGC 1301TGCAACTGCC CACCGCCTAC CTCGTCTGCA ACTTCGCCCC GCCCGTCGGC 1351GGCAAAGAAG CGCGTTTAAG CCACGACGAA ATCCTCACCC TCTTCCACGA 1401AacCGGCCAC GGACTGCACC ACCTGCTTAC CCAAGTGGAC GAACTGGGCG 1451TGTCCGGCAT CAAcggcgtA GAATGGGACG CGGTCGAACT GCCCAGCCAG 1501TTTATGGAAA ACTTCGTTTG GGAATACAAT GTATTGGCAC AAATGTCCGC 1551CCACGAAGAA AccgGCGAGC CCCTGCCGAA AGAACTCTTC GACAAAATGC 1601TcgcCGCCAA AAACTTCCAG CGCGGTATGT TCCTCGTCCG GCAAATGGAG 1651TTCGCCCTCT TCGATATGAT GATTTACAGT GAAAGCGACG AATGCCGTCT 1701GAAAAACTGG CAGCAGGTTT TAGACAGCGT GCGCAAAGAA GTcGCCGTCA 1751TCCAACCGCC CGAATACAAC CGCTTCGCCA ACAGCTTCGG CCacatctTC 1801GCcggcGGCT ATTCCGCAGG CTATTACAGC TACGCATGGG CCGAAGTCCt 1851cAGCACCGAT GCCTACGCCG CCTTTGAAGA AAGcGACGac gtcGCCGCCA 1901CAGGCAAACG CTTCTGGCAA GAAAtccttg ccgtcggcgg ctCCCGCAGC 1951gcgGCGGAAT CCTTCAAAGC CTTCCGCGGA CGCGAACCGA GCATAGACGC 2001ACTGCTGCGC CAaagcggtT TCGACAACGC gGCttgAThis corresponds to the amino acid sequence <SEQ ID 3088; ORF 128.ng>:

g128.pep 1 MIDNALLHLG EEPRFNQIQT EDIKPAVQTA IAEARGQIAA VKAQTHTGWA 51NTVERLTGIT ERVGRIWGVV SHLNSVVDTP ELRAVYNELM PEITVFFTEI 101GQDIELYNRF KTIKNSPEFA TLSPAQKTKL DHDLRDFVLS GAELPPERQA 151ELAKLQTEGA QLSAKFSQNV LDATDAFGIY FDDAAPLAGI PEDALAMFAA 201AAQSEGKTGY KIGLQIPHYL AVIQYAGNRE LREQIYRAYV TRASELSNDG 251KFDNTANIDR TLENALKTAK LLGFKNYAEL SLATKMADTP EQVLNFLHDL 301ARRAKPYAEK DLAEVKAFAR EHLGLADPQP WDLSYAGEKL REAKYAFSET 351EVKKYFPVGK VLAGLFAQIK KLYGIGFAEK TVPVWHKDVR YFELQQNGKT 401IGGVYMDLYA REGKRGGAWM NDYKGRRRFA DGTLQLPTAY LVCNFAPPVG 451GKEARLSHDE ILTLFHETGH GLHHLLTQVD ELGVSGINGV EWDAVELPSQ 501FMENFVWEYN VLAQMSAHEE TGEPLPKELF DKMLAAKNFQ RGMFLVRQME 551FALFDMMIYS ESDECRLKNW QQVLDSVRKE VAVIQPPEYN RFANSFGHIF 601AGGYSAGYYS YAWAEVLSTD AYAAFEESDD VAATGKRFWQ EILAVGGSRS 651AAESFKAFRG REPSIDALLR QSGFDNAA*ORF 128 shows 91.7% identity over a 475 aa overlap with a predicted ORF(ORF 128.ng) from N. gonorrhoeae:

m128/g128         10        20        30        40        50        60g128.pep MIDNALLHLGEEPRFNQIQTEDIKPAVQTAIAEARGQIAAVKAQTHTGWANTVERLTGIT ||||||||||||||:||:|||||||:|||||||| ||||:||||||||||||| ||||| m128MTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT        10        20        30        40        50        60        70        80        90       100       110       120 g128.pepERVGRIWGVVSHLNSVVDTPELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFA|||||||||||||| |:|||||||||||||||||||||||||||||||||||||||||| m128ERVGRIWGVVSHLNCVADTPELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFD        70        80        90       100       110       120       130       140       150       160       170       180 g128.pepTLSPAQKTKLDHDLRDFVLSGAELPPERQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY||||||||||:| m128 TLSPAQKTKLNH        130   //                                 340       350       360 g128.pep                              YAGEKLREAKYAFSETEVKKYFPVGKVLAG                              ||:||||||||||||| |||||||| || | m128                              YASEKLREAKYAFSETXVKKYFPVGXVLNG                                      10        20        30   370       380       390       400       410       420 g128.pepLFAQIKKLYGIGFAEKTVPVWHKDVRYFELQQNGKTIGGVYMDLYAREGKRGGAWMNDYK ||||||||||||:||||||||||||| ||||||::|||||||||||||||||||||||| m128LFAQXKKLYGIGFTEKTVPVWHKDVRYXELQQNGEXIGGVYMDLYAREGKRGGAWMNDYK        40        50        60        70        80        90   430       440       450       460       470       480 g128.pepGRRRFADGTLQLPTAYLVCNFAPPVGGKEARLSHDEILTLFHETGHGLHHLLTQVDELGV|||||:|||||||||||||||||||||:|||||||||| ||||||||||||||||||||| m128GRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILILFHETGHGLHHLLTQVDELGV       100       110       120       130       140       150   490       500       510       520       530       540 g128.pepSGINGVEWDAVELPSQFMENFVWEYNVLAQMSAHEETGEPLPKELFDKMLAAKNFQRGMF ||||||||||||||||||||||||||||| ||||||| |||||| || ||||||| ||| m128SGINGVXWDAVELPSQFMENFVWEYNVLAQXSAHEETGVPLPKELXDKXLAAKNFQXGMF       160       170       180       190       200       210   550       560       570       580       590       600 g128.pepLVRQMEFALFDMMIYSESDECRLKNWQQVLDSVRKEVAVIQPPEYNRFANSFGHIFAGGY  |||||||||||||||:|| ||||||||||||||:||||||||||||| |||||||||| m128XVRQXEFALFDMMIYSEDDEGRLKNWQQVLDSVRKKVAVIQPPEYNRFALSFGHIFAGGY       220       230       240       250       260       270   610       620       630       640       650       660 g128.pepSAGYYSYAWAEVLSTDAYAAFEESDDVAATGKRFWQEILAVGGSRSAAESFKAFRGREPS||: ||||||||||:||||||||||||||||||||||||||| |||:||||||||||||| m128SAAXYSYAWAEVLSADAYAAFEESDDVAATGKRFWQEILAVGXSRSGAESFKAFRGREPS       280       290       300       310       320       330   670      679 g128.pep IDALLRQSGFDNAAX ||||||:||||||: m128IDALLRHSGFDNAVX        340The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3089>:

a128.seq 1 ATGACTGACA ACGCACTGCT CCATTTGGGC GAAGAACCCC GTTTTGATCA 51AATCAAAACC GAAGACATCA AACCCGCCCT GCAAACCGCC ATTGCCGAAG 101CGCGCGAACA AATCGCCGCC ATCAAAGCCC AAACGCACAC CGGCTGGGCA 151AACACTGTCG AACCCCTGAC CGGCATCACC GAACGCGTCG GCAGGATTTG 201GGGCGTGGTG TCGCACCTCA ACTCCGTCAC CGACACGCCC GAACTGCGCG 251CCGCCTACAA TGAATTAATG CCCGAAATTA CCGTCTTCTT CACCGAAATC 301GGACAAGACA TCGAGCTGTA CAACCGCTTC AAAACCATCA AAAACTCCCC 351CGAGTTCGAC ACCCTCTCCC ACGCGCAAAA AACCAAACTC AACCACGATC 401TGCGCGATTT CGTCCTCAGC GGCGCGGAAC TGCCGCCCGA ACAGCAGGCA 451GAATTGGCAA AACTGCAAAC CGAAGGCGCG CAACTTTCCG CCAAATTCTC 501CCAAAACGTC CTAGACGCGA CCGACGCGTT CGGCATTTAC TTTGACGATG 551CCGCACCGCT TGCCGGCATT CCCGAAGACG CGCTCGCCAT GTTTGCCGCT 601GCCGCGCAAA GCGAAGGCAA AACAGGCTAC AAAATCGGTT TGCAGATTCC 651GCACTACCTC GCCGTCATCC AATACGCCGA CAACCGCAAA CTGCGCGAAC 701AAATCTACCG CGCCTACGTT ACCCGCGCCA GCGAGCTTTC AGACGACGGC 751AAATTCGACA ACACCGCCAA CATCGACCGC ACGCTCGAAA ACGCCCTGCA 801AACCGCCAAA CTGCTCGGCT TCAAAAACTA CGCCGAATTG TCGCTGGCAA 851CCAAAATGGC GGACACCCCC GAACAAGTTT TAAACTTCCT GCACGACCTC 901GCCCGCCGCG CCAAACCCTA CGCCGAAAAA GACCTCGCCG AAGTCAAAGC 951CTTCGCCCGC GAAAGCCTCG GCCTCGCCGA TTTGCAACCG TGGGACTTGG 1001GCTACGCCGG CGAAAAACTG CGCGAAGCCA AATACGCATT CAGCGAAACC 1051GAAGTCAAAA AATACTTCCC CGTCGGCAAA GTATTAAACG GACTGTTCGC 1101CCAAATCAAA AAACTCTACG GCATCGGATT TACCGAAAAA ACCGTCCCCG 1151TCTGGCACAA AGACGTGCGC TATTTTGAAT TGCAACAAAA CGGCGAAACC 1201ATAGGCGGCG TTTATATGGA TTTGTACGCA CGCGAAGGCA AACGCGGCGG 1251CGCGTGGATG AACGACTACA AAGGCCGCCG CCGTTTTTCA GACGGCACGC 1301TGCAACTGCC CACCGCCTAC CTCGTCTGCA ACTTCACCCC GCCCGTCGGC 1351GGCAAAGAAG CCCGCTTGAG CCATGACGAA ATCCTCACCC TCTTCCACGA 1401AACCGGACAC GGCCTGCACC ACCTGCTTAC CCAAGTCGAC GAACTGGGCG 1451TATCCGGCAT CAACGGCGTA GAATGGGACG CAGTCGAACT GCCCAGTCAG 1501TTTATGGAAA ATTTCGTTTG GGAATACAAT GTCTTGGCGC AAATGTCCGC 1551CCACGAAGAA ACCGGCGTTC CCCTGCCGAA AGAACTCTTC GACAAAATGC 1601TCGCCGCCAA AAACTTCCAA CGCGGAATGT TCCTCGTCCG CCAAATGGAG 1651TTCGCCCTCT TTGATATGAT GATTTACAGC GAAGACGACG AAGGCCGTCT 1701GAAAAACTGG CAACAGGTTT TAGACAGCGT GCGCAAAGAA GTCGCCGTCG 1751TCCGACCGCC CGAATACAAC CGCTTCGCCA ACAGCTTCGG CCACATCTTC 1801GCAGGCGGCT ATTCCGCAGG CTATTACAGC TACGCGTGGG CGGAAGTATT 1851GAGCGCGGAC GCATACGCCG CCTTTGAAGA AAGCGACGAT GTCGCCGCCA 1901CAGGCAAACG CTTTTGGCAG GAAATCCTCG CCGTCGGCGG ATCGCGCAGC 1951GCGGCAGAAT CCTTCAAAGC CTTCCGCGGA CGCGAACCGA GCATAGACGC 2001ACTCTTGCGC CACAGCGGCT TCGACAACGC GGCTTGAThis corresponds to the amino acid sequence <SEQ ID 3090; ORF 128.a>:

a128.pep 1 MTDNALLHLG EEPRFDQIKT EDIKPALQTA IAEAREQIAA IKAQTHTGWA 51NTVEPLTGIT ERVGRIWGVV SHLNSVTDTP ELRAAYNELM PEITVFFTEI 101GQDIELYNRF KTIKNSPEFD TLSHAQKTKL NHDLRDFVLS GAELPPEQQA 151ELAKLQTEGA QLSAKFSQNV LDATDAFGIY FDDAAPLAGI PEDALAMFAA 201AAQSEGKTGY KIGLQIPHYL AVIQYADNRK LREQIYRAYV TRASELSDDG 251KFDNTANIDR TLENALQTAK LLGFKNYAEL SLATKMADTP EQVLNFLHDL 301ARRAKPYAEK DLAEVKAFAR ESLGLADLQP WDLGYAGEKL REAKYAFSET 351EVKKYFPVGK VLNGLFAQIK KLYGIGFTEK TVPVWHKDVR YFELQQNGET 401IGGVYMDLYA REGKRGGAWM NDYKGRRRFS DGTLQLPTAY LVCNFTPPVG 451GKEARLSHDE ILTLFHETGH GLHHLLTQVD ELGVSGINGV EWDAVELPSQ 501FMENFVWEYN VLAQMSAHEE TGVPLPKELF DKMLAAKNFQ RGMFLVRQME 551FALFDMMIYS EDDEGRLKNW QQVLDSVRKE VAVVRPPEYN RFANSFGHIF 601AGGYSAGYYS YAWAEVLSAD AYAAFEESDD VAATGKRFWQ EILAVGGSRS 651AAESFKAFRG REPSIDALLR HSGFDNAA* m128/a12866.0% identity in 677 aa overlap         10        20        30        40        50        60 m128.pep MTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a128 MTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT         10        20        30        40        50        60         70        80        90       100       110       120 m128.pep ERVGRIWGVVSHLNCVADTPELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFD |||||||||||||| |:|||||||:||||||||||||||||||||||||||||||||||| a128 ERVGRIWGVVSHLNSVTDTPELRAAYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFD         70        80        90       100       110       120        130 m128.pep TLSPAQKTKLNH------------------------------------------------  ||||||||||| a128 TLSHAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY        130       140       150       160       170       180 m128.pep ------------------------------------------------------------ a128 FDDAAPLAGIPEDALAMFAAAAQSEGKTGYKIGLQIPHYLAVIQYADNRKLREQIYRAYV        190       200       210       220       230       240 m128.pep ------------------------------------------------------------ a128 TRASELSDDGKFDNTANIDRTLENALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDL        250       260       270       280       290       300                                        140       150 m128.pep ----------------------------------YASEKLREAKYAFSETXVKKYFPVGX                                   ||:||||||||||||| |||||||| a128 ARRAKPYAEKDLAEVKAFARESLGLADLQPWDLGYAGEKLREAKYAFSETEVKKYFPVGK        310       320       330       340       350       360160       170       180       190       200       210 m128.pep VLNGLFAQXKKLYGIGFTEKTVPVWHKDVRYXELQQNGEXIGGVYMDLYAREGKRGGAWM  |||||||||||||||||||||||||||||| |||||||:|||||||||||||||||||| a128 VLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGETIGGVYMDLYAREGKRGGAWM        370       380       390       400       410       420220       230       240       250       260       270 m128.pep NDYKGRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILILFHETGHGLHHLLTQVD |||||||||||||||||||||||||:|||||:|||||||||| ||||||||||||||||| a128 NDYKGRRRFSDGTLQLPTAYLVCNFTPPVGGKEARLSHDEILTLFHETGHGLHHLLTQVD        430       440       450       460       470       480280       290       300       310       320       330 m128.pep ELGVSGINGVXWDAVELPSQFMENFVWEYNVLAQXSAHEETGVPLPKELXDKXLAAKNFQ |||||||||| |||||||||||||||||||| ||||||||||||||||| || ||||||| a128 ELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSAHEETGVPLPKELFDKMLAAKNFQ        490       500       510       520       530       540340       350       360       370       380       390 m128.pep XGMFXVRQXEFALFDMMIYSEDDEGRLKNWQQVLDSVRKKVAVIQPPEYNRFALSFGHIF   ||| |||||||||||||||||||||||||||||||||:|||::|||||||| |||||| a128 RGMFLVRQMEFALFDMMIYSEDDEGRLKNWQQVLDSVRKEVAVVRPPEYNRFANSFGHIF        550       560       570       580       590       600400       410       420       430       440       450 m128.pep AGGYSAAXYSYAWAEVLSADAYAAFEESDDVAATGKRFWQEILAVGXSRSGAESFKAFRG ||||||: |||||||||||||||||||||||||||||||||||||| |||:||||||||| a128 AGGYSAGYYSYAWAEVLSADAYAAFEESDDVAATGKRFWQEILAVGGSRSAAESFKAFRG        610       620       630       640       650       660460       470 m128.pep  REPSIDALLRHSGFDNAVX  |||||||||||||||||: a128 REPSIDALLRHSGFDNAAX         670The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3091>:

m128-1.seq 1 ATGACTGACA ACGCACTGCT CCATTTGGGC GAAGAACCCC GTTTTGATCA 51AATCAAAACC GAAGACATCA AACCCGCCCT GCAAACCGCC ATCGCCGAAG 101CGCGCGAACA AATCGCCGCC ATCAAAGCCC AAACGCACAC CGGCTGGGCA 151AACACTGTCG AACCCCTGAC CGGCATCACC GAACGCGTCG GCAGGATTTG 201GGGCGTGGTG TCGCACCTCA ACTCCGTCGC CGACACGCCC GAACTGCGCG 251CCGTCTATAA CGAACTGATG CCCGAAATCA CCGTCTTCTT CACCGAAATC 301GGACAAGACA TCGAGCTGTA CAACCGCTTC AAAACCATCA AAAATTCCCC 351CGAATTCGAC ACCCTCTCCC CCGCACAAAA AACCAAACTC AACCACGATC 401TGCGCGATTT CGTCCTCAGC GGCGCGGAAC TGCCGCCCGA ACAGCAGGCA 451GAACTGGCAA AACTGCAAAC CGAAGGCGCG CAACTTTCCG CCAAATTCTC 501CCAAAACGTC CTAGACGCGA CCGACGCGTT CGGCATTTAC TTTGACGATG 551CCGCACCGCT TGCCGGCATT CCCGAAGACG CGCTCGCCAT GTTTGCCGCC 601GCCGCGCAAA GCGAAAGCAA AACAGGCTAC AAAATCGGCT TGCAGATTCC 651ACACTACCTC GCCGTCATCC AATACGCCGA CAACCGCGAA CTGCGCGAAC 701AAATCTACCG CGCCTACGTT ACCCGCGCCA GCGAACTTTC AGACGACGGC 751AAATTCGACA ACACCGCCAA CATCGACCGC ACGCTCGCAA ACGCCCTGCA 801AACCGCCAAA CTGCTCGGCT TCAAAAACTA CGCCGAATTG TCGCTGGCAA 851CCAAAATGGC GGACACGCCC GAACAAGTTT TAAACTTCCT GCACGACCTC 901GCCCGCCGCG CCAAACCCTA CGCCGAAAAA GACCTCGCCG AAGTCAAAGC 951CTTCGCCCGC GAAAGCCTGA ACCTCGCCGA TTTGCAACCG TGGGACTTGG 1001GCTACGCCAG CGAAAAACTG CGCGAAGCCA AATACGCGTT CAGCGAAACC 1051GAAGTCAAAA AATACTTCCC CGTCGGCAAA GTATTAAACG GACTGTTCGC 1101CCAAATCAAA AAACTCTACG GCATCGGATT TACCGAAAAA ACCGTCCCCG 1151TCTGGCACAA AGACGTGCGC TATTTTGAAT TGCAACAAAA CGGCGAAACC 1201ATAGGCGGCG TTTATATGGA TTTGTACGCA CGCGAAGGCA AACGCGGCGG 1251CGCGTGGATG AACGACTACA AAGGCCGCCG CCGTTTTTCA GACGGCACGC 1301TGCAACTGCC CACCGCCTAC CTCGTCTGCA ACTTCGCCCC ACCCGTCGGC 1351GGCAGGGAAG CCCGCCTGAG CCACGACGAA ATCCTCATCC TCTTCCACGA 1401AACCGGACAC GGGCTGCACC ACCTGCTTAC CCAAGTGGAC GAACTGGGCG 1451TATCCGGCAT CAACGGCGTA GAATGGGACG CGGTCGAACT GCCCAGCCAG 1501TTTATGGAAA ATTTCGTTTG GGAATACAAT GTCTTGGCAC AAATGTCAGC 1551CCACGAAGAA ACCGGCGTTC CCCTGCCGAA AGAACTCTTC GACAAAATGC 1601TCGCCGCCAA AAACTTCCAA CGCGGCATGT TCCTCGTCCG GCAAATGGAG 1651TTCGCCCTCT TTGATATGAT GATTTACAGC GAAGACGACG AAGGCCGTCT 1701GAAAAACTGG CAACAGGTTT TAGACAGCGT GCGCAAAAAA GTCGCCGTCA 1751TCCAGCCGCC CGAATACAAC CGCTTCGCCT TGAGCTTCGG CCACATCTTC 1801GCAGGCGGCT ATTCCGCAGG CTATTACAGC TACGCGTGGG CGGAAGTATT 1851GAGCGCGGAC GCATACGCCG CCTTTGAAGA AAGCGACGAT GTCGCCGCCA 1901CAGGCAAACG CTTTTGGCAG GAAATCCTCG CCGTCGGCGG ATCGCGCAGC 1951GCGGCAGAAT CCTTCAAAGC CTTCCGCGGC CGCGAACCGA GCATAGACGC 2001ACTCTTGCGC CACAGCGGTT TCGACAACGC GGTCTGAThis corresponds to the amino acid sequence <SEQ ID 3092; ORF 128-1>:

m128-1.pep. 1 MTDNALLHLG EEPRFDQIKT EDIKPALQTA IAEAREQIAA IKAQTHTGWA 51NTVEPLTGIT ERVGRIWGVV SHLNSVADTP ELRAVYNELM PEITVFFTEI 101GQDIELYNRF KTIKNSPEFD TLSPAQKTKL NHDLRDFVLS GAELPPEQQA 151ELAKLQTEGA QLSAKFSQNV LDATDAFGIY FDDAAPLAGI PEDALAMFAA 201AAQSESKTGY KIGLQIPHYL AVIQYADNRE LREQIYRAYV TRASELSDDG 251KFDNTANIDR TLANALQTAK LLGFKNYAEL SLATKMADTP EQVLNFLHDL 301ARRAKPYAEK DLAEVKAFAR ESLNLADLQP WDLGYASEKL REAKYAFSET 351EVKKYFPVGK VLNGLFAQIK KLYGIGFTEK TVPVWHKDVR YFELQQNGET 401IGGVYMDLYA REGKRGGAWM NDYKGRRRFS DGTLQLPTAY LVCNFAPPVG 451GREARLSHDE ILILFHETGH GLHHLLTQVD ELGVSGINGV EWDAVELPSQ 501FMENFVWEYN VLAQMSAHEE TGVPLPKELF DKMLAAKNFQ RGMFLVRQME 551FALFDMMIYS EDDEGRLKNW QQVLDSVRKK VAVIQPPEYN RFALSFGHIF 601AGGYSAGYYS YAWAEVLSAD AYAAFEESDD VAATGKRFWQ EILAVGGSRS 651AAESFKAFRG REPSIDALLR HSGFDNAV*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3093>:

g128-1.seq (partial) 1ATGATTGACA ACGCACTGCT CCACTTGGGC GAAGAACCCC GTTTTAATCA 51AATCAAAACC GAAGACATCA AACCCGCCGT CCAAACCGCC ATCGCCGAAG 101CGCGCGGACA AATCGCCGCC GTCAAAGCGC AAACGCACAC CGGCTGGGCG 151AACACCGTCG AGCGTCTGAC CGGCATCACC GAACGCGTCG GCAGGATTTG 201GGGCGTCGTG TCCCATCTCA ACTCCGTCGT CGACACGCCC GAACTGCGCG 251CCGTCTATAA CGAACTGATG CCTGAAATCA CCGTCTTCTT CACCGAAATC 301GGACAAGACA TCGAACTGTA CAACCGCTTC AAAACCATCA AAAATTCCCC 351CGAATTTGCA ACGCTTTCCC CCGCACAAAA AACCAAGCTC GATCACGACC 401TGCGCGATTT CGTATTGAGC GGCGCGGAAC TGCCGCCCGA ACGGCAGGCA 451GAACTGGCAA AACTGCAAAC CGAAGGCGCG CAACTTTCCG CCAAATTCTC 501CCAAAACGTC CTAGACGCGA CCGACGCGTT CGGCATTTAC TTTGACGATG 551CCGCACCGCT TGCCGGCATT CCCGAAGACG CGCTCGCCAT GTTTGCCGCC 601GCCGCGCAAA GCGAAGGCAA AACAGGTTAC AAAATCGGCT TGCAGATTCC 651GCACTACCTT GCCGTTATCC AATACGCCGG CAACCGCGAA CTGCGCGAAC 701AAATCTACCG CGCCTACGTT ACCCGTGCCA GCGAACTTTC AAACGACGGC 751AAATTCGACA ACACCGCCAA CATCGACCGC ACGCTCGAAA ACGCATTGAA 801AACCGCCAAA CTGCTCGGCT TTAAAAATTA CGCCGAATTG TCGCTGGCAA 851CCAAAATGGC GGACACGCCC GAACAGGTTT TAAACTTCCT GCACGACCTC 901GCCCGCCGCG CCAAACCCTA CGCCGAAAAA GACCTCGCCG AAGTCAAAGC 951CTTCGCCCGC GAACACCTCG GTCTCGCCGA CCCGCAGCCG TGGGACTTGA 1001GCTACGCCGG CGAAAAACTG CGCGAAGCCA AATACGCATT CAGCGAAACC 1051GAAGTCAAAA AATACTTCCC CGTCGGCAAA GTTCTGGCAG GCCTGTTCGC 1101CCAAATCAAA AAACTCTACG GCATCGGATT CGCCGAAAAA ACCGTTCCCG 1151TCTGGCACAA AGACGTGCGC TATTTTGAAT TGCAACAAAA CGGCAAAACC 1201ATCGGCGGCG TTTATATGGA TTTGTACGCA CGCGAAGGCA AACGCGGCGG 1251CGCGTGGATG AACGACTACA AAGGCCGCCG CCGCTTTGCC GACGGCACGC 1301TGCAACTGCC CACCGCCTAC CTCGTCTGCA ACTTCGCCCC GCCCGTCGGC 1351GGCAAAGAAG CGCGTTTAAG CCACGACGAA ATCCTCACCC TCTTCCACGA 1401AACCGGCCAC GGACTGCACC ACCTGCTTAC CCAAGTGGAC GAACTGGGCG 1451TGTCCGGCAT CAACGGCGTA AAAThis corresponds to the amino acid sequence <SEQ ID 3094; ORF 128-1.ng>:

g128-1.pep (partial) 1MIDNALLHLG EEPRFNQIKT EDIKPAVQTA IAEARGQIAA VKAQTHTGWA 51NTVERLTGIT ERVGRIWGVV SHLNSVVDTP ELRAVYNELM PEITVFFTEI 101GQDIELYNRF KTIKNSPEFA TLSPAQKTKL DHDLRDFVLS GAELPPERQA 151ELAKLQTEGA QLSAKFSQNV LDATDAFGIY FDDAAPLAGI PEDALAMFAA 201AAQSEGKTGY KIGLQIPHYL AVIQYAGNRE LREQIYRAYV TRASELSNDG 251KFDNTANIDR TLENALKTAK LLGFKNYAEL SLATKMADTP EQVLNFLHDL 301ARRAKPYAEK DLAEVKAFAR EHLGLADPQP WDLSYAGEKL REAKYAFSET 351EVKKYFPVGK VLAGLFAQIK KLYGIGFAEK TVPVWHKDVR YFELQQNGKT 401IGGVYMDLYA REGKRGGAWM NDYKGRRRFA DGTLQLPTAY LVCNFAPPVG 451GKEARLSHDE ILTLFHETGH GLHHLLTQVD ELGVSGINGV K m128-1/g128-194.5% identity in 491 aa overlap        10        20        30        40        50        60 g128-1.pepMIDNALLHLGEEPRFNQIKTEDIKPAVQTAIAEARGQIAAVKAQTHTGWANTVERLTGIT ||||||||||||||:||||||||||:|||||||| ||||:||||||||||||| ||||| m128-1MTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT        10        20        30        40        50        60        70        80        90       100       110       120 g128-1.pepERVGRIWGVVSHLNSVVDTPELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFA||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||| m128-1ERVGRIWGVVSHLNSVADTPELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFD        70        80        90       100       110       120       130       140       150       160       170       180 g128-1.pepTLSPAQKTKLDHDLRDFVLSGAELPPERQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY||||||||||:||||||||||||||||:|||||||||||||||||||||||||||||||| m128-1TLSPAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY       130       140       150       160       170       180       190       200       210       220       230       240 g128-1.pepFDDAAPLAGIPEDALAMFAAAAQSEGKTGYKIGLQIPHYLAVIQYAGNRELREQIYRAYV|||||||||||||||||||||||||:|||||||||||||||||||| ||||||||||||| m128-1FDDAAPLAGIPEDALAMFAAAAQSESKTGYKIGLQIPHYLAVIQYADNRELREQIYRAYV       190       200       210       220       230       240       250       260       270       280       290       300 g128-1.pepTRASELSNDGKFDNTANIDRTLENALKTAKLLGFKNYAELSLATKMADTPEQVLNFLHDL|||||||:|||||||||||||| |||:||||||||||||||||||||||||||||||||| m128-1TRASELSDDGKFDNTANIDRTLANALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDL       250       260       270       280       290       300       310       320       330       340       350       360 g128-1.pepARRAKPYAEKDLAEVKAFAREHLGLADPQPWDLSYAGEKLREAKYAFSETEVKKYFPVGK||||||||||||||||||||| |:||| |||||:||:||||||||||||||||||||||| m128-1ARRAKPYAEKDLAEVKAFARESLNLADLQPWDLGYASEKLREAKYAFSETEVKKYFPVGK       310       320       330       340       350       360       370       380       390       400       410       420 g128-1.pepVLAGLFAQIKKLYGIGFAEKTVPVWHKDVRYFELQQNGKTIGGVYMDLYAREGKRGGAWM ||||||||||||||||:||||||||||||||||||||:||||||||||||||||||||| m128-1VLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGETIGGVYMDLYAREGKRGGAWM       370       380       390       400       410       420       430       440       450       460       470       480 g128-1.pepNDYKGRRRFADGTLQLPTAYLVCNFAPPVGGKEARLSHDEILTLFHETGHGLHHLLTQVD|||||||||:|||||||||||||||||||||:|||||||||| ||||||||||||||||| m128-1NDYKGRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILILFHETGHGLHHLLTQVD       430       440       450       460       470       480        490g128-1.pep ELGVSGINGVK ||||||||||: m128-1ELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSAHEETGVPLPKELFDKMLAAKNFQ       490       500       510       520       530       540The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3095>:

a128-1.seq 1 ATGACTGACA ACGCACTGCT CCATTTGGGC GAAGAACCCC GTTTTGATCA 51AATCAAAACC GAAGACATCA AACCCGCCCT GCAAACCGCC ATTGCCGAAG 101CGCGCGAACA AATCGCCGCC ATCAAAGCCC AAACGCACAC CGGCTGGGCA 151AACACTGTCG AACCCCTGAC CGGCATCACC GAACGCGTCG GCAGGATTTG 201GGGCGTGGTG TCGCACCTCA ACTCCGTCAC CGACACGCCC GAACTGCGCG 251CCGCCTACAA TGAATTAATG CCCGAAATTA CCGTCTTCTT CACCGAAATC 301GGACAAGACA TCGAGCTGTA CAACCGCTTC AAAACCATCA AAAACTCCCC 351CGAGTTCGAC ACCCTCTCCC ACGCGCAAAA AACCAAACTC AACCACGATC 401TGCGCGATTT CGTCCTCAGC GGCGCGGAAC TGCCGCCCGA ACAGCAGGCA 451GAATTGGCAA AACTGCAAAC CGAAGGCGCG CAACTTTCCG CCAAATTCTC 501CCAAAACGTC CTAGACGCGA CCGACGCGTT CGGCATTTAC TTTGACGATG 551CCGCACCGCT TGCCGGCATT CCCGAAGACG CGCTCGCCAT GTTTGCCGCT 601GCCGCGCAAA GCGAAGGCAA AACAGGCTAC AAAATCGGTT TGCAGATTCC 651GCACTACCTC GCCGTCATCC AATACGCCGA CAACCGCAAA CTGCGCGAAC 701AAATCTACCG CGCCTACGTT ACCCGCGCCA GCGAGCTTTC AGACGACGGC 751AAATTCGACA ACACCGCCAA CATCGACCGC ACGCTCGAAA ACGCCCTGCA 801AACCGCCAAA CTGCTCGGCT TCAAAAACTA CGCCGAATTG TCGCTGGCAA 851CCAAAATGGC GGACACCCCC GAACAAGTTT TAAACTTCCT GCACGACCTC 901GCCCGCCGCG CCAAACCCTA CGCCGAAAAA GACCTCGCCG AAGTCAAAGC 951CTTCGCCCGC GAAAGCCTCG GCCTCGCCGA TTTGCAACCG TGGGACTTGG 1001GCTACGCCGG CGAAAAACTG CGCGAAGCCA AATACGCATT CAGCGAAACC 1051GAAGTCAAAA AATACTTCCC CGTCGGCAAA GTATTAAACG GACTGTTCGC 1101CCAAATCAAA AAACTCTACG GCATCGGATT TACCGAAAAA ACCGTCCCCG 1151TCTGGCACAA AGACGTGCGC TATTTTGAAT TGCAACAAAA CGGCGAAACC 1201ATAGGCGGCG TTTATATGGA TTTGTACGCA CGCGAAGGCA AACGCGGCGG 1251CGCGTGGATG AACGACTACA AAGGCCGCCG CCGTTTTTCA GACGGCACGC 1301TGCAACTGCC CACCGCCTAC CTCGTCTGCA ACTTCACCCC GCCCGTCGGC 1351GGCAAAGAAG CCCGCTTGAG CCATGACGAA ATCCTCACCC TCTTCCACGA 1401AACCGGACAC GGCCTGCACC ACCTGCTTAC CCAAGTCGAC GAACTGGGCG 1451TATCCGGCAT CAACGGCGTA GAATGGGACG CAGTCGAACT GCCCAGTCAG 1501TTTATGGAAA ATTTCGTTTG GGAATACAAT GTCTTGGCGC AAATGTCCGC 1551CCACGAAGAA ACCGGCGTTC CCCTGCCGAA AGAACTCTTC GACAAAATGC 1601TCGCCGCCAA AAACTTCCAA CGCGGAATGT TCCTCGTCCG CCAAATGGAG 1651TTCGCCCTCT TTGATATGAT GATTTACAGC GAAGACGACG AAGGCCGTCT 1701GAAAAACTGG CAACAGGTTT TAGACAGCGT GCGCAAAGAA GTCGCCGTCG 1751TCCGACCGCC CGAATACAAC CGCTTCGCCA ACAGCTTCGG CCACATCTTC 1801GCAGGCGGCT ATTCCGCAGG CTATTACAGC TACGCGTGGG CGGAAGTATT 1851GAGCGCGGAC GCATACGCCG CCTTTGAAGA AAGCGACGAT GTCGCCGCCA 1901CAGGCAAACG CTTTTGGCAG GAAATCCTCG CCGTCGGCGG ATCGCGCAGC 1951GCGGCAGAAT CCTTCAAAGC CTTCCGCGGA CGCGAACCGA GCATAGACGC 2001ACTCTTGCGC CACAGCGGCT TCGACAACGC GGCTTGAThis corresponds to the amino acid sequence <SEQ ID 3096; ORF 128-1.a>:

a128-1.pep 1 MTDNALLHLG EEPRFDQIKT EDIKPALQTA IAEAREQIAA IKAQTHTGWA 51NTVEPLTGIT ERVGRIWGVV SHLNSVTDTP ELRAAYNELM PEITVFFTEI 101GQDIELYNRF KTIKNSPEFD TLSHAQKTKL NHDLRDFVLS GAELPPEQQA 151ELAKLQTEGA QLSAKFSQNV LDATDAFGIY FDDAAPLAGI PEDALAMFAA 201AAQSEGKTGY KIGLQIPHYL AVIQYADNRK LREQIYRAYV TRASELSDDG 251KFDNTANIDR TLENALQTAK LLGFKNYAEL SLATKMADTP EQVLNFLHDL 301ARRAKPYAEK DLAEVKAFAR ESLGLADLQP WDLGYAGEKL REAKYAFSET 351EVKKYFPVGK VLNGLFAQIK KLYGIGFTEK TVPVWHKDVR YFELQQNGET 401IGGVYMDLYA REGKRGGAWM NDYKGRRRFS DGTLQLPTAY LVCNFTPPVG 451GKEARLSHDE ILTLFHETGH GLHHLLTQVD ELGVSGINGV EWDAVELPSQ 501FMENFVWEYN VLAQMSAHEE TGVPLPKELF DKMLAAKNFQ RGMFLVRQME 551FALFDMMIYS EDDEGRLKNW QQVLDSVRKE VAVVRPPEYN RFANSFGHIF 601AGGYSAGYYS YAWAEVLSAD AYAAFEESDD VAATGKRFWQ EILAVGGSRS 651AAESFKAFRG REPSIDALLR HSGFDNAA* m128-1/a128-197.8% identity in 677 aa overlap        10        20        30        40        50        60 a128-1.pepMTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m128-1MIDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHIGWANTVEPLIGIT        10        20        30        40        50        60        70        80        90       100       110       120 a128-1.pepERVGRIWGVVSHLNSVTDTPELRAAYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFD||||||||||||||||:|||||||:||||||||||||||||||||||||||||||||||| m128-1ERVGRIWGVVSHLNSVADTPELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFD        70        80        90       100       110       120       130       140       150       160       170       180 a128-1.pepTLSHAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m128-1TLSPAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY       130       140       150       160       170       180       190       200       210       220       230       240 a128-1.pepFDDAAPLAGIPEDALAMFAAAAQSEGKTGYKIGLQIPHYLAVIQYADNRKLREQIYRAYV|||||||||||||||||||||||||:|||||||||||||||||||||||:|||||||||| m128-1FDDAAPLAGIPEDALAMFAAAAQSESKTGYKIGLQIPHYLAVIQYADNRELREQIYRAYV       190       200       210       220       230       240       250       260       270       280       290       300 a128-1.pepTRASELSDDGKFDNTANIDRTLENALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDL|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| m128-1TRASELSDDGKFDNTANIDRTLANALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDL       250       260       270       280       290       300       310       320       330       340       350       360 a128-1.pepARRAKPYAEKDLAEVKAFARESLGLADLQPWDLGYAGEKLREAKYAFSETEVKKYFPVGK|||||||||||||||||||||||:||||||||||||:||||||||||||||||||||||| m128-1ARRAKPYAEKDLAEVKAFARESLNLADLQPWDLGYASEKLREAKYAFSETEVKKYFPVGK       310       320       330       340       350       360       370       380       390       400       410       420 a128-1.pepVLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGETIGGVYMDLYAREGKRGGAWM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m128-1VLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGETIGGVYMDLYAREGKRGGAWM       370       380       390       400       410       420       430       440       450       460       470       480 a128-1.pepNDYKGRRRFSDGTLQLPTAYLVCNFTPPVGGKEARLSHDEILTLFHETGHGLHHLLTQVD|||||||||||||||||||||||||:|||||:|||||||||| ||||||||||||||||| m128-1NDYKGRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILILFHETGHGLHHLLTQVD       430       440       450       460       470       480       490       500       510       520       530       540 a128-1.pepELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSAHEETGVPLPKELFDKMLAAKNFQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m128-1ELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSAHEETGVPLPKELFDKMLAAKNFQ       490       500       510       520       530       540       550       560       570       580       590       600 a128-1.pepRGMFLVRQMEFALFDMMIYSEDDEGRLKNWQQVLDSVRKEVAVVRPPEYNRFANSFGHIF|||||||||||||||||||||||||||||||||||||||:|||::|||||||| |||||| m128-1RGMFLVRQMEFALFDMMIYSEDDEGRLKNWQQVLDSVRKKVAVIQPPEYNRFALSFGHIF       550       560       570       580       590       600       610       620       630       640       650       660 a128-1.pepAGGYSAGYYSYAWAEVLSADAYAAFEESDDVAATGKRFWQEILAVGGSRSAAESFKAFRG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m128-1AGGYSAGYYSYAWAEVLSADAYAAFEESDDVAATGKRFWQEILAVGGSRSAAESFKAFRG       610       620       630       640       650       660       670      679 a128-1.pep REPSIDALLRHSGFDNAAX |||||||||||||||||:m128-1 REPSIDALLRHSGFDNAVX        670206The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3097>:

m206.seq 1 ATGTTTCCCC CCGACAAAAC CCTTTTCCTC TGTCTCAGCG CACTGCTCCT 51CGCCTCATGC GGCACGACCT CCGGCAAACA CCGCCAACCG AAACCCAAAC 101AGACAGTCCG GCAAATCCAA GCCGTCCGCA TCAGCCACAT CGACCGCACA 151CAAGGCTCGC AGGAACTCAT GCTCCACAGC CTCGGACTCA TCGGCACGCC 201CTACAAATGG GGCGGCAGCA GCACCGCAAC CGGCTTCGAT TGCAGCGGCA 251TGATTCAATT CGTTTACAAr AACGCCCTCA ACGTCAAGCT GCCGCGCACC 301GCCCGCGACA TGGCGGCGGC AAGCCGsAAA ATCCCCGAcA GCCGCyTCAA 351GGCCGGCGAC CTCGTATTCT TCAACACCGG CGGCGCACAC CGCTACTCAC 401ACGTCGGACT CTACATCGGC AACGGCGAAT TCATCCATGC CCCCAGCAGC 451GGCAAAACCA TCAAAACCGA AAAACTCTCC ACACCGTTTT ACGCCAAAAA 501CTACCTCGGC GCACATACTT TTTTTACAGA ATGAThis corresponds to the amino acid sequence <SEQ ID 3098; ORF 206>:

m206.pep.. 1 MFPPDKTLFL CLSALLLASC GTTSGKHRQP KPKQTVRQIQ AVRISHIDRT 51QGSQELMLHS LGLIGTPYKW GGSSTATGFD CSGMIQFVYK NALNVKLPRT 101 ARDMAAASRKIPDSRXKAGD LVFFNTGGAH RYSHVGLYIG NGEFIHAPSS 151 GKTIKTEKLS TPFYAKNYLGAHTFFTE*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3099>:

g206.seq 1 atgttttccc ccgacaaaac ccttttcctc tgtctcggcg cactgctcct 51cgcctcatgc ggcacgacct ccggcaaaca ccgccaaccg aaacccaaac 101 agacagtccggcaaatccaa gccgtccgca tcagccacat cggccgcaca 151 caaggctcgc aggaactcatgctccacagc ctcggactca tcggcacgcc 201 ctacaaatgg ggcggcagca gcaccgcaaccggcttcgac tgcagcggca 251 tgattcaatt ggtttacaaa aacgccctca acgtcaagctgccgcgcacc 301 gcccgcgaca tggcggcggc aagccgcaaa atccccgaca gccgcctcaa351 ggccggcgac atcgtattct tcaacaccgg cggcgcacac cgctactcac 401acgtcggact ctacatcggc aacggcgaat tcatccatgc ccccggcagc 451 ggcaaaaccatcaaaaccga aaaactctcc acaccgtttt acgccaaaaa 501 ctaccttgga gcgcatacgttttttacaga atgaThis corresponds to the amino acid sequence <SEQ ID 3100; ORF 206.ng>:

g206.pep 1 MFSPDKTLFL CLGALLLASC GTTSGKHRQP KPKQTVRQIQ AVRISHIGRT 51QGSQELMLHS LGLIGTPYKW GGSSTATGFD CSGMIQLVYK NALNVKLPRT 101 ARDMAAASRKIPDSRLKAGD IVFFNTGGAH RYSHVGLYIG NGEFIHAPGS 151 GKTIKTEKLS TPFYAKNYLGAHTFFTE*ORF 206 shows 96.0% identity over a 177 aa overlap with a predicted ORF(ORF 206.ng) from N. gonorrhoeae:

m206/g206         10        20        30        40        50        60m206.pep MFPPDKTLFLCLSALLLASCGTTSGKHRQPKPKQTVRQIQAVRISHIDRTQGSQELMLHS|| |||||||||:|||||||||||||||||||||||||||||||||| |||||||||||| g206MFSPDKTLFLCLGALLLASCGTTSGKHRQPKPKQTVRQIQAVRISHIGRTQGSQELMLHS        10        20        30        40        50        60        70        80        90       100       110       120 m206.pepLGLIGTPYKWGGSSTATGFDCSGMIQFVYKNALNVKLPRTARDMAAASRKIPDSRXKAGD||||||||||||||||||||||||||:|||||||||||||||||||||||||||| |||| g206LGLIGTPYKWGGSSTATGFDCSGMIQLVYKNALNVKLPRTARDMAAASRKIPDSRLKAGD        70        80        90       100       110       120       130       140       150       160       170 m206.pepLVFFNTGGAHRYSHVGLYIGNGEFIHAPSSGKTIKTEKLSTPFYAKNYLGAHTFFTEX:|||||||||||||||||||||||||||:|||||||||||||||||||||||||||| g206IVFFNTGGAHRYSHVGLYIGNGEFIHAPGSGKTIKTEKLSTPFYAKNYLGAHTFFTE       130       140       150       160       170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3101>:

a206.seq 1 ATGTTTCCCC CCGACAAAAC CCTTTTCCTC TGTCTCAGCG CACTGCTCCT 51CGCCTCATGC GGCACGACCT CCGGCAAACA CCGCCAACCG AAACCCAAAC 101 AGACAGTCCGGCAAATCCAA GCCGTCCGCA TCAGCCACAT CGACCGCACA 151 CAAGGCTCGC AGGAACTCATGCTCCACAGC CTCGGACTCA TCGGCACGCC 201 CTACAAATGG GGCGGCAGCA GCACCGCAACCGGCTTCGAT TGCAGCGGCA 251 TGATTCAATT CGTTTACAAA AACGCCCTCA ACGTCAAGCTGCCGCGCACC 301 GCCCGCGACA TGGCGGCGGC AAGCCGCAAA ATCCCCGACA GCCGCCTTAA351 GGCCGGCGAC CTCGTATTCT TCAACACCGG CGGCGCACAC CGCTACTCAC 401ACGTCGGACT CTATATCGGC AACGGCGAAT TCATCCATGC CCCCAGCAGC 451 GGCAAAACCATCAAAACCGA AAAACTCTCC ACACCGTTTT ACGCCAAAAA 501 CTACCTCGGC GCACATACTTTCTTTACAGA ATGAThis corresponds to the amino acid sequence <SEQ ID 3102; ORF 206.a>:

a206.pep 1 MFPPDKTLFL CLSALLLASC GTTSGKHRQP KPKQTVRQIQ AVRISHIDRT 51QGSQELMLHS LGLIGTPYKW GGSSTATGFD CSGMIQFVYK NALNVKLPRT 101 ARDMAAASRKIPDSRLKAGD LVFFNTGGAH RYSHVGLYIG NGEFIHAPSS 151 GKTIKTEKLS TPFYAKNYLGAHTFFTE* m206/a206 99.4% identity in 177 aa overlap        10        20        30        40        50        60 m206.pepMFPPDKTLFLCLSALLLASCGTTSGKHRQPKPKQTVRQIQAVRISHIDRTQGSQELMLHS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a206MFPPDKTLFLCLSALLLASCGTTSGKHRQPKPKQTVRQIQAVRISHIDRTQGSQELMLHS        10        20        30        40        50        60        70        80        90       100       110       120 m206.pepLGLIGTPYKWGGSSTATGFDCSGMIQFVYKNALNVKLPRTARDMAAASRKIPDSRXKAGD||||||||||||||||||||||||||||||||||||||||||||||||||||||| |||| a206LGLIGTPYKWGGSSTATGFDCSGMIQFVYKNALNVKLPRTARDMAAASRKIPDSRLKAGD        70        80        90       100       110       120       130       140       150       160       170 m206.pepLVFFNTGGAHRYSHVGLYIGNGEFIHAPSSGKTIKTEKLSTPFYAKNYLGAHTFFTEX|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a206LVFFNTGGAHRYSHVGLYIGNGEFIHAPSSGKTIKTEKLSTPFYAKNYLGAHTFFTEX       130       140       150       160       170287The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3103>:

m287.seq 1 ATGTTTAAAC GCAGCGTAAT CGCAATGGCT TGTATTTTTG CCCTTTCAGC 51CTGCGGGGGC GGCGGTGGCG GATCGCCCGA TGTCAAGTCG GCGGACACGC 101 TGTCAAAACCTGCCGCCCCT GTTGTTTCTG AAAAAGAGAC AGAGGCAAAG 151 GAAGATGCGC CACAGGCAGGTTCTCAAGGA CAGGGCGCGC CATCCGCACA 201 AGGCAGTCAA GATATGGCGG CGGTTTCGGAAGAAAATACA GGCAATGGCG 251 GTGCGGTAAC AGCGGATAAT CCCAAAAATG AAGACGAGGTGGCACAAAAT 301 GATATGCCGC AAAATGCCGC CGGTACAGAT AGTTCGACAC CGAATCACAC351 CCCGGATCCG AATATGCTTG CCGGAAATAT GGAAAATCAA GCAACGGATG 401CCGGGGAATC GTCTCAGCCG GCAAACCAAC CGGATATGGC AAATGCGGCG 451 GACGGAATGCAGGGGGACGA TCCGTCGGCA GGCGGGCAAA ATGCCGGCAA 501 TACGGCTGCC CAAGGTGCAAATCAAGCCGG AAACAATCAA GCCGCCGGTT 551 CTTCAGATCC CATCCCCGCG TCAAACCCTGCACCTGCGAA TGGCGGTAGC 601 AATTTTGGAA GGGTTGATTT GGCTAATGGC GTTTTGATTGACGGGCCGTC 651 GCAAAATATA ACGTTGACCC ACTGTAAAGG CGATTCTTGT AGTGGCAATA701 ATTTCTTGGA TGAAGAAGTA CAGCTAAAAT CAGAATTTGA AAAATTAAGT 751GATGCAGACA AAATAAGTAA TTACAAGAAA GATGGGAAGA ATGATAAATT 801 TGTCGGTTTGGTTGCCGATA GTGTGCAGAT GAAGGGAATC AATCAATATA 851 TTATCTTTTA TAAACCTAAACCCACTTCAT TTGCGCGATT TAGGCGTTCT 901 GCACGGTCGA GGCGGTCGCT TCCGGCCGAGATGCCGCTGA TTCCCGTCAA 951 TCAGGCGGAT ACGCTGATTG TCGATGGGGA AGCGGTCAGCCTGACGGGGC 1001 ATTCCGGCAA TATCTTCGCG CCCGAAGGGA ATTACCGGTA TCTGACTTAC1051 GGGGCGGAAA AATTGCCCGG CGGATCGTAT GCCCTTCGTG TTCAAGGCGA 1101ACCGGCAAAA GGCGAAATGC TTGCGGGCGC GGCCGTGTAC AACGGCGAAG 1151 TACTGCATTTCCATACGGAA AACGGCCGTC CGTACCCGAC CAGGGGCAGG 1201 TTTGCCGCAA AAGTCGATTTCGGCAGCAAA TCTGTGGACG GCATTATCGA 1251 CAGCGGCGAT GATTTGCATA TGGGTACGCAAAAATTCAAA GCCGCCATCG 1301 ATGGAAACGG CTTTAAGGGG ACTTGGACGG AAAATGGCAGCGGGGATGTT 1351 TCCGGAAAGT TTTACGGCCC GGCCGGCGAG GAAGTGGCGG GAAAATACAG1401 CTATCGCCCG ACAGATGCGG AAAAGGGCGG ATTCGGCGTG TTTGCCGGCA 1451AAAAAGAGCA GGATTGAThis corresponds to the amino acid sequence <SEQ ID 3104; ORF 287>:

m287.pep 1 MFKRSVIAMA CIFALSACGG GGGGSPDVKS ADTLSKPAAP VVSEKETEAK 51EDAPQAGSQG QGAPSAQGSQ DMAAVSEENT GNGGAVTADN PKNEDEVAQN 101 DMPQNAAGTDSSTPNHTPDP NMLAGNMENQ ATDAGESSQP ANQPDMANAA 151 DGMQGDDPSA GGQNAGNTAAQGANQAGNNQ AAGSSDPIPA SNPAPANGGS 201 NFGRVDLANG VLIDGPSQNI TLTHCKGDSCSGNNFLDEEV QLKSEFEKLS 251 DADKISNYKK DGKNDKFVGL VADSVQMKGI NQYIIFYKPKPTSFARFRRS 301 ARSRRSLPAE MPLIPVNQAD TLIVDGEAVS LTGHSGNIFA PEGNYRYLTY351 GAEKLPGGSY ALRVQGEPAK GEMLAGAAVY NGEVLHFHTE NGRPYPTRGR 401FAAKVDFGSK SVDGIIDSGD DLHMGTQKFK AAIDGNGFKG TWTENGSGDV 451 SGKFYGPAGEEVAGKYSYRP TDAEKGGFGV FAGKKEQD*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3105>:

g287.seq 1 atgtttaaac gcagtgtgat tgcaatggct tgtatttttc ccctttcagc 51ctgtgggggc ggcggtggcg gatcgcccga tgtcaagtcg gcggacacgc 101 cgtcaaaaccggccgccccc gttgttgctg aaaatgccgg ggaaggggtg 151 ctgccgaaag aaaagaaagatgaggaggca gcgggcggtg cgccgcaagc 201 cgatacgcag gacgcaaccg ccggagaaggcagccaagat atggcggcag 251 tttcggcaga aaatacaggc aatggcggtg cggcaacaacggacaacccc 301 aaaaatgaag acgcgggggc gcaaaatgat atgccgcaaa atgccgccga351 atccgcaaat caaacaggga acaaccaacc cgccggttct tcagattccg 401cccccgcgtc aaaccctgcc cctgcgaatg gcggtagcga ttttggaagg 451 acgaacgtgggcaattctgt tgtgattgac ggaccgtcgc aaaatataac 501 gttgacccac tgtaaaggcgattcttgtaa tggtgataat ttattggatg 551 aagaagcacc gtcaaaatca gaatttgaaaaattaagtga tgaagaaaaa 601 attaagcgat ataaaaaaga cgagcaacgg gagaattttgtcggtttggt 651 tgctgacagg gtaaaaaagg atggaactaa caaatatatc atcttctata701 cggacaaacc acctactcgt tctgcacggt cgaggaggtc gcttccggcc 751gagattccgc tgattcccgt caatcaggcc gatacgctga ttgtggatgg 801 ggaagcggtcagcctgacgg ggcattccgg caatatcttc gcgcccgaag 851 ggaattaccg gtatctgacttacggggcgg aaaaattgcc cggcggatcg 901 tatgccctcc gtgtgcaagg cgaaccggcaaaaggcgaaa tgcttgttgg 951 cacggccgtg tacaacggcg aagtgctgca tttccatatggaaaacggcc 1001 gtccgtaccc gtccggaggc aggtttgccg caaaagtcga tttcggcagc1051 aaatctgtgg acggcattat cgacagcggc gatgatttgc atatgggtac 1101gcaaaaattc aaagccgcca tcgatggaaa cggctttaag gggacttgga 1151 cggaaaatggcggcggggat gtttccggaa ggttttacgg cccggccggc 1201 gaggaagtgg cgggaaaatacagctatcgc ccgacagatg ctgaaaaggg 1251 cggattcggc gtgtttgccg gcaaaaaagatcgggattgaThis corresponds to the amino acid sequence <SEQ ID 3106; ORF 287.ng>:

g287.pep 1 MFKRSVIAMA CIFPLSACGG GGGGSPDVKS ADTPSKPAAP VVAENAGEGV 51LPKEKKDEEA AGGAPQADTQ DATAGEGSQD MAAVSAENTG NGGAATTDNP 101 KNEDAGAQNDMPQNAAESAN QTGNNQPAGS SDSAPASNPA PANGGSDFGR 151 TNVGNSVVID GPSQNITLTHCKGDSCNGDN LLDEEAPSKS EFEKLSDEEK 201 IKRYKKDEQR ENFVGLVADR VKKDGTNKYIIFYTDKPPTR SARSRRSLPA 251 EIPLIPVNQA DTLIVDGEAV SLTGHSGNIF APEGNYRYLTYGAEKLPGGS 301 YALRVQGEPA KGEMLVGTAV YNGEVLHFHM ENGRPYPSGG RFAAKVDFGS351 KSVDGIIDSG DDLHMGTQKF KAAIDGNGFK GTWTENGGGD VSGRFYGPAG 401EEVAGKYSYR PTDAEKGGFG VFAGKKDRD* m287/g287 70.1% identity in 499 aaoverlap           10        20        30        40                  49m287.pep   MFKRSVIAMACIFALSACGGGGGGSPDVKSADTLSKPAAPVVSE-----------KETEA  ||||||||||||| ||||||||||||||||||| ||||||||:|           |: || g287  MFKRSVIAMACIFPLSACGGGGGGSPDVKSADTPSKPAAPVVAENAGEGVLPKEKKDEEA          10        20        30        40        50        60 50        60        70        80        90       100      109 m287.pep  KEDAPQAGSQGQGAPSAQGSQDMAAVSEENTGNGGAVTADNPKNEDEVAQNDMPQNAAGT     |||| :|   | :::||||||||| ||||||||:|:|||||||  |||||||||| g287  AGGAPQADTQD--ATAGEGSQDMAAVSAENTGNGGAATTDNPKNEDAGAQNDMPQNAA--          70          80        90       100       110110       120       130       140       150       160      169 m287.pep  DSSTPNHTPDPNMLAGNMENQATDAGESSQPANQPDMANAADGMQGDDPSAGGQNAGNTA g287  ------------------------------------------------------------170       180       190       200       210       220      229 m287.pep  AQGANQAGNNQAAGSSDPIPASNPAPANGGSNFGRVDLANGVLIDGPSQNITLTHCKGDS   ::|||:|||| |||||  ||||||||||||:|||::::|:|:||||||||||||||||| g287  -ESANQTGNNQPAGSSDSAPASNPAPANGGSDFGRTNVGNSVVIDGPSQNITLTHCKGDS    120       130       140       150       160       170230       240       250       260       270       280      289 m287.pep  CSGNNFLDEEVQLKSEFEKLSDADKISNYKKDGKNDKFVGLVADSVQMKGINQYIIFYKP  |:|:|:||||:  ||||||||| :||: |||| : ::||||||| |:  | |:||||| g287  CNGDNLLDEEAPSKSEFEKLSDEEKIKRYKKDEQRENFVGLVADRVKKDGTNKYIIFYTD    180       190       200       210       220       230290       300       310       320       330       340      349 m287.pep  KPTSFARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRYLT  || :     ||||||||||||:|||||||||||||||||||||||||||||||||||||| g287  KPPT-----RSARSRRSLPAEIPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRYLT         240       250       260       270       280       290350       360       370       380       390       400      409 m287.pep  YGAEKLPGGSYALRVQGEPAKGEMLAGAAVYNGEVLHFHTENGRPYPTRGRFAAKVDFGS  |||||||||||||||||||||||||:|:||||||||||| |||||||: ||||||||||| g287  YGAEKLPGGSYALRVQGEPAKGEMLVGTAVYNGEVLHFHMENGRPYPSGGRFAAKVDFGS         300       310       320       330       340       350410       420       430       440       450       460      469 m287.pep  KSVDGIIDSGDDLHMGTQKFKAAIDGNGFKGTWTENGSGDVSGKFYGPAGEEVAGKYSYR  |||||||||||||||||||||||||||||||||||||:|||||:|||||||||||||||| g287  KSVDGIIDSGDDLHMGTQKFKAAIDGNGFKGTWTENGGGDVSGRFYGPAGEEVAGKYSYR         360       370       380       390       400       410470       480      489 m287.pep   PTDAEKGGFGVFAGKKEQDX  ||||||||||||||||::|| g287   PTDAEKGGFGVFAGKKDRDX         420       430The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3107>:

a287.seq 1 ATGTTTAAAC GCAGTGTGAT TGCAATGGCT TGTATTGTTG CCCTTTCAGC 51CTGTGGGGGC GGCGGTGGCG GATCGCCCGA TGTTAAGTCG GCGGACACGC 101 TGTCAAAACCTGCCGCCCCT GTTGTTACTG AAGATGTCGG GGAAGAGGTG 151 CTGCCGAAAG AAAAGAAAGATGAGGAGGCG GTGAGTGGTG CGCCGCAAGC 201 CGATACGCAG GACGCAACCG CCGGAAAAGGCGGTCAAGAT ATGGCGGCAG 251 TTTCGGCAGA AAATACAGGC AATGGCGGTG CGGCAACAACGGATAATCCC 301 GAAAATAAAG ACGAGGGACC GCAAAATGAT ATGCCGCAAA ATGCCGCCGA351 TACAGATAGT TCGACACCGA ATCACACCCC TGCACCGAAT ATGCCAACCA 401GAGATATGGG AAACCAAGCA CCGGATGCCG GGGAATCGGC ACAACCGGCA 451 AACCAACCGGATATGGCAAA TGCGGCGGAC GGAATGCAGG GGGACGATCC 501 GTCGGCAGGG GAAAATGCCGGCAATACGGC AGATCAAGCT GCAAATCAAG 551 CTGAAAACAA TCAAGTCGGC GGCTCTCAAAATCCTGCCTC TTCAACCAAT 601 CCTAACGCCA CGAATGGCGG CAGCGATTTT GGAAGGATAAATGTAGCTAA 651 TGGCATCAAG CTTGACAGCG GTTCGGAAAA TGTAACGTTG ACACATTGTA701 AAGACAAAGT ATGCGATAGA GATTTCTTAG ATGAAGAAGC ACCACCAAAA 751TCAGAATTTG AAAAATTAAG TGATGAAGAA AAAATTAATA AATATAAAAA 801 AGACGAGCAACGAGAGAATT TTGTCGGTTT GGTTGCTGAC AGGGTAGAAA 851 AGAATGGAAC TAACAAATATGTCATCATTT ATAAAGACAA GTCCGCTTCA 901 TCTTCATCTG CGCGATTCAG GCGTTCTGCACGGTCGAGGC GGTCGCTTCC 951 GGCCGAGATG CCGCTGATTC CCGTCAATCA GGCGGATACGCTGATTGTCG 1001 ATGGGGAAGC GGTCAGCCTG ACGGGGCATT CCGGCAATAT CTTCGCGCCC1051 GAAGGGAATT ACCGGTATCT GACTTACGGG GCGGAAAAAT TGTCCGGCGG 1101ATCGTATGCC CTCAGTGTGC AAGGCGAACC GGCAAAAGGC GAAATGCTTG 1151 CGGGCACGGCCGTGTACAAC GGCGAAGTGC TGCATTTCCA TATGGAAAAC 1201 GGCCGTCCGT CCCCGTCCGGAGGCAGGTTT GCCGCAAAAG TCGATTTCGG 1251 CAGCAAATCT GTGGACGGCA TTATCGACAGCGGCGATGAT TTGCATATGG 1301 GTACGCAAAA ATTCAAAGCC GTTATCGATG GAAACGGCTTTAAGGGGACT 1351 TGGACGGAAA ATGGCGGCGG GGATGTTTCC GGAAGGTTTT ACGGCCCGGC1401 CGGCGAAGAA GTGGCGGGAA AATACAGCTA TCGCCCGACA GATGCGGAAA 1451AGGGCGGATT CGGCGTGTTT GCCGGCAAAA AAGAGCAGGA TTGAThis corresponds to the amino acid sequence <SEQ ID 3108; ORF 287.a>:

a287.pep 1 MFKRSVIAMA CIVALSACGG GGGGSPDVKS ADTLSKPAAP VVTEDVGEEV 51LPKEKKDEEA VSGAPQADTQ DATAGKGGQD MAAVSAENTG NGGAATTDNP 101 ENKDEGPQNDMPQNAADTDS STPNHTPAPN MPTRDMGNQA PDAGESAQPA 151 NQPDMANAAD GMQGDDPSAGENAGNTADQA ANQAENNQVG GSQNPASSTN 201 PNATNGGSDF GRINVANGIK LDSGSENVTLTHCKDKVCDR DFLDEEAPPK 251 SEFEKLSDEE KINKYKKDEQ RENFVGLVAD RVEKNGTNKYVIIYKDKSAS 301 SSSARFRRSA RSRRSLPAEM PLIPVNQADT LIVDGEAVSL TGHSGNIFAP351 EGNYRYLTYG AEKLSGGSYA LSVQGEPAKG EMLAGTAVYN GEVLHFHMEN 401GRPSPSGGRF AAKVDFGSKS VDGIIDSGDD LHMGTQKFKA VIDGNGFKGT 451 WTENGGGDVSGRFYGPAGEE VAGKYSYRPT DAEKGGFGVF AGKKEQD* m287/a287 77.2% identity in501 aa overlap          10        20        30        40                  49 m287.pep  MFKRSVIAMACIFALSACGGGGGGSPDVKSADTLSKPAAPVVSE-----------KETEA  |||||||||||| |||||||||||||||||||||||||||||:|           |: || a287  MFKRSVIAMACIVALSACGGGGGGSPDVKSADTLSKPAAPVVTEDVGEEVLPKEKKDEEA          10        20        30        40        50        60 50        60        70        80        90       100      109 m287.pep  KEDAPQAGSQGQGAPSAQGSQDMAAVSEENTGNGGAVTADNPKNEDEVAQNDMPQNAAGT     |||| :|   | :::|:||||||| ||||||||:|:|||:|:||  ||||||||| | a287  VSGAPQADTQ--DATAGKGGQDMAAVSAENTGNGGAATTDNPENKDEGPQNDMPQNAADT          70          80        90       100       110110       120       130       140       150       160      169 m287.pep  DSSTPNHTPDPNMLAGNMENQATDAGESSQPANQPDMANAADGMQGDDPSAGGQNAGNTA  ||||||||| ||| : :| ||| |||||:||||||||||||||||||||||| :|||||| a287  DSSTPNHTPAPNMPTRDMGNQAPDAGESAQPANQPDMANAADGMQGDDPSAG-ENAGNTA 120       130       140       150       160       170170       180       190       200       210       220      229 m287.pep  AQGANQAGNNQAAGSSDPIPASNPAPANGGSNFGRVDLANGVLIDGPSQNITLTHCKGDS   |:|||| |||::||::|  ::||  :||||:|||:::|||: :|: |:|:|||||| a287  DQAANQAENNQVGGSQNPASSTNPNATNGGSDFGRINVANGIKLDSGSENVTLTHCKDKV  180       190       200       210       220       230230       240       250       260       270       280      289 m287.pep  CSGNNFLDEEVQLKSEFEKLSDADKISNYKKDGKNDKFVGLVADSVQMKGINQYIIFYKP  |:  :|||||:  ||||||||| :||::|||| : ::||||||| |: :| |:|:|:|| a287  CD-RDFLDEEAPPKSEFEKLSDEEKINKYKKDEQRENFVGLVADRVEKNGTNKYVIIYKD   240       250       260       270       280       290290         300       310       320       330       340 m287.pep  KP--TSFARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRY  |   :| ||||||||||||||||||||||||||||||||||||||||||||||||||||| a287  KSASSSSARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRY   300       310       320       330       340       350  350       360       370       380       390       400 m287.pep  LTYGAEKLPGGSYALRVQGEPAKGEMLAGAAVYNGEVLHFHTENGRPYPTRGRFAAKVDF  |||||||| |||||| |||||||||||||:||||||||||| ||||| |: ||||||||| a287  LTYGAEKLSGGSYALSVQGEPAKGEMLAGTAVYNGEVLHFHMENGRPSPSGGRFAAKVDF   360       370       380       390       400       410  410       420       430       440       450       460 m287.pep  GSKSVDGIIDSGDDLHMGTQKFKAAIDGNGFKGTWTENGSGDVSGKFYGPAGEEVAGKYS  ||||||||||||||||||||||||:||||||||||||||:|||||:|||||||||||||| a287  GSKSVDGIIDSGDDLHMGTQKFKAVIDGNGFKGTWTENGGGDVSGRFYGPAGEEVAGKYS   420       430       440       450       460       470  470       480      489 m287.pep   YRPTDAEKGGFGVFAGKKEQDX  |||||||||||||||||||||| a287   YRPTDAEKGGFGVFAGKKEQDX    480       490406The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3109>:

m406.seq 1 ATGCAAGCAC GGCTGCTGAT ACCTATTCTT TTTTCAGTTT TTATTTTATC 51CGCCTGCGGG ACACTGACAG GTATTCCATC GCATGGCGGA GGTAAACGCT 101 TTGCGGTCGAACAAGAACTT GTGGCCGCTT CTGCCAGAGC TGCCGTTAAA 151 GACATGGATT TACAGGCATTACACGGACGA AAAGTTGCAT TGTACATTGC 201 CACTATGGGC GACCAAGGTT CAGGCAGTTTGACAGGGGGT CGCTACTCCA 251 TTGATGCACT GATTCGTGGC GAATACATAA ACAGCCCTGCCGTCCGTACC 301 GATTACACCT ATCCACGTTA CGAAACCACC GCTGAAACAA CATCAGGCGG351 TTTGACAGGT TTAACCACTT CTTTATCTAC ACTTAATGCC CCTGCACTCT 401CTCGCACCCA ATCAGACGGT AGCGGAAGTA AAAGCAGTCT GGGCTTAAAT 451 ATTGGCGGGATGGGGGATTA TCGAAATGAA ACCTTGACGA CTAACCCGCG 501 CGACACTGCC TTTCTTTCCCACTTGGTACA GACCGTATTT TTCCTGCGCG 551 GCATAGACGT TGTTTCTCCT GCCAATGCCGATACAGATGT GTTTATTAAC 601 ATCGACGTAT TCGGAACGAT ACGCAACAGA ACCGAAATGCACCTATACAA 651 TGCCGAAACA CTGAAAGCCC AAACAAAACT GGAATATTTC GCAGTAGACA701 GAACCAATAA AAAATTGCTC ATCAAACCAA AAACCAATGC GTTTGAAGCT 751GCCTATAAAG AAAATTACGC ATTGTGGATG GGGCCGTATA AAGTAAGCAA 801 AGGAATTAAACCGACGGAAG GATTAATGGT CGATTTCTCC GATATCCGAC 851 CATACGGCAA TCATACGGGTAACTCCGCCC CATCCGTAGA GGCTGATAAC 901 AGTCATGAGG GGTATGGATA CAGCGATGAAGTAGTGCGAC AACATAGACA 951 AGGACAACCT TGAThis corresponds to the amino acid sequence <SEQ ID 3110; ORF 406>:

m406.pep 1 MQARLLIPIL FSVFILSACG TLTGIPSHGG GKRFAVEQEL VAASARAAVK 51DMDLQALHGR KVALYIATMG DQGSGSLTGG RYSIDALIRG EYINSPAVRT 101 DYTYPRYETTAETTSGGLTG LTTSLSTLNA PALSRTQSDG SGSKSSLGLN 151 IGGMGDYRNE TLTTNPRDTAFLSHLVQTVF FLRGIDVVSP ANADTDVFIN 201 IDVFGTIRNR TEMHLYNAET LKAQTKLEYFAVDRTNKKLL IKPKTNAFEA 251 AYKENYALWM GPYKVSKGIK PTEGLMVDFS DIRPYGNHTGNSAPSVEADN 301 SHEGYGYSDE VVRQHRQGQP *The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3111>:

g406.seq 1 ATGCGGGCAC GGCTGCTGAT ACCTATTCTT TTTTCAGTTT TTATTTTATC 51CGCCTGCGGG ACACTGACAG GTATTCCATC GCATGGCGGA GGCAAACGCT 101 TCGCGGTCGAACAAGAACTT GTGGCCGCTT CTGCCAGAGC TGCCGTTAAA 151 GACATGGATT TACAGGCATTACACGGACGA AAAGTTGCAT TGTACATTGC 201 AACTATGGGC GACCAAGGTT CAGGCAGTTTGACAGGGGGT CGCTACTCCA 251 TTGATGCACT GATTCGCGGC GAATACATAA ACAGCCCTGCCGTCCGCACC 301 GATTACACCT ATCCGCGTTA CGAAACCACC GCTGAAACAA CATCAGGCGG351 TTTGACGGGT TTAACCACTT CTTTATCTAC ACTTAATGCC CCTGCACTCT 401CGCGCACCCA ATCAGACGGT AGCGGAAGTA GGAGCAGTCT GGGCTTAAAT 451 ATTGGCGGGATGGGGGATTA TCGAAATGAA ACCTTGACGA CCAACCCGCG 501 CGACACTGCC TTTCTTTCCCACTTGGTGCA GACCGTATTT TTCCTGCGCG 551 GCATAGACGT TGTTTCTCCT GCCAATGCCGATACAGATGT GTTTATTAAC 601 ATCGACGTAT TCGGAACGAT ACGCAACAGA ACCGAAATGCACCTATACAA 651 TGCCGAAACA CTGAAAGCCC AAACAAAACT GGAATATTTC GCAGTAGACA701 GAACCAATAA AAAATTGCTC ATCAAACCCA AAACCAATGC GTTTGAAGCT 751GCCTATAAAG AAAATTACGC ATTGTGGATG GGGCCGTATA AAGTAAGCAA 801 AGGAATCAAACCGACGGAAG GATTGATGGT CGATTTCTCC GATATCCAAC 851 CATACGGCAA TCATACGGGTAACTCCGCCC CATCCGTAGA GGCTGATAAC 901 AGTCATGAGG GGTATGGATA CAGCGATGAAGCAGTGCGAC AACATAGACA 951 AGGGCAACCT TGAThis corresponds to the amino acid sequence <SEQ ID 3112; ORF 406>:

g406.pep 1 MRARLLIPIL FSVFILSACG TLTGIPSHGG GKRFAVEQEL VAASARAAVK 51DMDLQALHGR KVALYIATMG DQGSGSLTGG RYSIDALIRG EYINSPAVRT 101 DYTYPRYETTAETTSGGLTG LTTSLSTLNA PALSRTQSDG SGSRSSLGLN 151 IGGMGDYRNE TLTTNPRDTAFLSHLVQTVF FLRGIDVVSP ANADTDVFIN 201 IDVFGTIRNR TEMHLYNAET LKAQTKLEYFAVDRTNKKLL IKPKTNAFEA 251 AYKENYALWM GPYKVSKGIK PTEGLMVDFS DIQPYGNHTGNSAPSVEADN 301 SHEGYGYSDE AVRQHRQGQP *ORF 406 shows 98.8% identity over a 320 aa overlap with a predicted ORF(ORF406.a) from N. gonorrhoeae:

g406/m406         10        20        30        40        50        60g406.pep MRARLLIPILFSVFILSACGTLTGIPSHGGGKRFAVEQELVAASARAAVKDMDLQALHGR|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m406MQARLLIPILFSVFILSACGTLTGIPSHGGGKRFAVEQELVAASARAAVKDMDLQALHGR        10        20        30        40        50        60        70        80        90       100       110       120 g406.pepKVALYIATMGDQGSGSLTGGRYSIDALIRGEYINSPAVRTDYTYPRYETTAETTSGGLTG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m406KVALYIATMGDQGSGSLTGGRYSIDALIRGEYINSPAVRTDYTYPRYETTAETTSGGLTG        70        80        90       100       110       120       130       140       150       160       170       180 g406.pepLTTSLSTLNAPALSRTQSDGSGSRSSLGLNIGGMGDYRNETLTTNPRDTAFLSHLVQTVF|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| m406LTTSLSTLNAPALSRTQSDGSGSKSSLGLNIGGMGDYRNETLTTNPRDTAFLSHLVQTVF       130       140       150       160       170       180       190       200       210       220       230       240 g406.pepFLRGIDVVSPANADTDVFINIDVFGTIRNRTEMHLYNAETLKAQTKLEYFAVDRTNKKLL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m406FLRGIDVVSPANADTDVFINIDVFGTIRNRTEMHLYNAETLKAQTKLEYFAVDRTNKKLL       190       200       210       220       230       240       250       260       270       280       290       300 g406.pepIKPKTNAFEAAYKENYALWMGPYKVSKGIKPTEGLMVDFSDIQPYGNHTGNSAPSVEADN||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||| m406IKPKTNAFEAAYKENYALWMGPYKVSKGIKPTEGLMVDFSDIRPYGNHTGNSAPSVEADN       250       260       270       280       290       300       310       320 g406.pep SHEGYGYSDEAVRQHRQGQPX||||||||||:|||||||||| m406 SHEGYGYSDEVVRQHRQGQPX        310       320The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3113>:

a406.seq 1 ATGCAAGCAC GGCTGCTGAT ACCTATTCTT TTTTCAGTTT TTATTTTATC 51CGCCTGCGGG ACACTGACAG GTATTCCATC GCATGGCGGA GGTAAACGCT 101 TCGCGGTCGAACAAGAACTT GTGGCCGCTT CTGCCAGAGC TGCCGTTAAA 151 GACATGGATT TACAGGCATTACACGGACGA AAAGTTGCAT TGTACATTGC 201 AACTATGGGC GACCAAGGTT CAGGCAGTTTGACAGGGGGT CGCTACTCCA 251 TTGATGCACT GATTCGTGGC GAATACATAA ACAGCCCTGCCGTCCGTACC 301 GATTACACCT ATCCACGTTA CGAAACCACC GCTGAAACAA CATCAGGCGG351 TTTGACAGGT TTAACCACTT CTTTATCTAC ACTTAATGCC CCTGCACTCT 401CGCGCACCCA ATCAGACGGT AGCGGAAGTA AAAGCAGTCT GGGCTTAAAT 451 ATTGGCGGGATGGGGGATTA TCGAAATGAA ACCTTGACGA CTAACCCGCG 501 CGACACTGCC TTTCTTTCCCACTTGGTACA GACCGTATTT TTCCTGCGCG 551 GCATAGACGT TGTTTCTCCT GCCAATGCCGATACGGATGT GTTTATTAAC 601 ATCGACGTAT TCGGAACGAT ACGCAACAGA ACCGAAATGCACCTATACAA 651 TGCCGAAACA CTGAAAGCCC AAACAAAACT GGAATATTTC GCAGTAGACA701 GAACCAATAA AAAATTGCTC ATCAAACCAA AAACCAATGC GTTTGAAGCT 751GCCTATAAAG AAAATTACGC ATTGTGGATG GGACCGTATA AAGTAAGCAA 801 AGGAATTAAACCGACAGAAG GATTAATGGT CGATTTCTCC GATATCCAAC 851 CATACGGCAA TCATATGGGTAACTCTGCCC CATCCGTAGA GGCTGATAAC 901 AGTCATGAGG GGTATGGATA CAGCGATGAAGCAGTGCGAC GACATAGACA 951 AGGGCAACCT TGAThis corresponds to the amino acid sequence <SEQ ID 3114; ORF 406.a>:

a406.pep 1 MQARLLIPIL FSVFILSACG TLTGIPSHGG GKRFAVEQEL VAASARAAVK 51DMDLQALHGR KVALYIATMG DQGSGSLTGG RYSIDALIRG EYINSPAVRT 101 DYTYPRYETTAETTSGGLTG LTTSLSTLNA PALSRTQSDG SGSKSSLGLN 151 IGGMGDYRNE TLTTNPRDTAFLSHLVQTVF FLRGIDVVSP ANADTDVFIN 201 IDVFGTIRNR TEMHLYNAET LKAQTKLEYFAVDRTNKKLL IKPKTNAFEA 251 AYKENYALWM GPYKVSKGIK PTEGLMVDFS DIQPYGNHMGNSAPSVEADN 301 SHEGYGYSDE AVRRHRQGQP * m406/a406 98.8% identity in 320aa overlap         10        20        30        40        50        60m406.pep MQARLLIPILFSVFILSACGTLTGIPSHGGGKRFAVEQELVAASARAAVKDMDLQALHGR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a406MQARLLIPILFSVFILSACGTLTGIPSHGGGKRFAVEQELVAASARAAVKDMDLQALHGR        10        20        30        40        50        60        70        80        90       100       110       120 m406.pepKVALYIATMGDQGSGSLTGGRYSIDALIRGEYINSPAVRTDYTYPRYETTAETTSGGLTG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a406KVALYIATMGDQGSGSLTGGRYSIDALIRGEYINSPAVRTDYTYPRYETTAETTSGGLTG        70        80        90       100       110       120       130       140       150       160       170       180 m406.pepLTTSLSTLNAPALSRTQSDGSGSKSSLGLNIGGMGDYRNETLTTNPRDTAFLSHLVQTVF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a406LTTSLSTLNAPALSRTQSDGSGSKSSLGLNIGGMGDYRNETLTTNPRDTAFLSHLVQTVF       130       140       150       160       170       180       190       200       210       220       230       240 m406.pepFLRGIDVVSPANADTDVFINIDVFGTIRNRTEMHLYNAETLKAQTKLEYFAVDRTNKKLL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a406FLRGIDVVSPANADTDVFINIDVFGTIRNRTEMHLYNAETLKAQTKLEYFAVDRTNKKLL       190       200       210       220       230       240       250       260       270       280       290       300 m406.pepIKPKTNAFEAAYKENYALWMGPYKVSKGIKPTEGLMVDFSDIRPYGNHTGNSAPSVEADN||||||||||||||||||||||||||||||||||||||||||:||||| ||||||||||| a406IKPKTNAFEAAYKENYALWMGPYKVSKGIKPTEGLMVDFSDIQPYGNHMGNSAPSVEADN       250       260       270       280       290       300       310       320 m406.pep SHEGYGYSDEVVRQHRQGQPX||||||||||:||:||||||| a406 SHEGYGYSDEAVRRHRQGQPX        310       320

Example 2 Expression of ORF 919

The primer described in Table 1 for ORF 919 was used to locate and cloneORF 919. The predicted gene 919 was cloned in pET vector and expressedin E. coli. The product of protein expression and purification wasanalyzed by SDS-PAGE. In panel A) is shown the analysis of 919-Hisfusion protein purification. Mice were immunized with the purified919-His and sera were used for Western blot (panel B), FACS analysis(panel C), bactericidal assay (panel D), and ELISA assay (panel E).Symbols: M1, molecular weight marker; PP, purified protein, TP, N.meningitidis total protein extract; OMV, N. meningitidis outer membranevesicle preparation. Arrows indicate the position of the mainrecombinant protein product (A) and the N. meningitidis immunoreactiveband (B). These experiments confirm that 919 is a surface-exposedprotein and that it is a useful immunogen. The hydrophilicity plots,antigenic index, and amphipatic regions of ORF 919 are provided in FIG.10. The AMPHI program is used to predict putative T-cell epitopes (Gaoet al 1989, J. Immunol 143:3007; Roberts et al. 1996, AIDS Res HumanRetroviruses 12:593; Quakyi et al. 1992, Scand J Immunol Suppl 11:9).The nucleic acid sequence of ORF 919 and the amino acid sequence encodedthereby is provided in Example 1.

Example 3 Expression of ORF 279

The primer described in Table 1 for ORF 279 was used to locate and cloneORF 279. The predicted gene 279 was cloned in pGex vector and expressedin E. coli. The product of protein expression and purification wasanalyzed by SDS-PAGE. In panel A) is shown the analysis of 279-GSTpurification. Mice were immunized with the purified 279-GST and serawere used for Western blot analysis (panel B), FACS analysis (panel C),bactericidal assay (panel D), and ELISA assay (panel E). Symbols: M1,molecular weight marker; TP, N. meningitidis total protein extract; OMV,N. meningitidis outer membrane vescicle preparation. Arrows indicate theposition of the main recombinant protein product (A) and the N.meningitidis immunoreactive band (B). These experiments confirm that 279is a surface-exposed protein and that it is a useful immunogen. Thehydrophilicity plots, antigenic index, and amphipatic regions of ORF 279are provided in FIG. 11. The AMPHI program is used to predict putativeT-cell epitopes (Gao et al 1989, J. Immunol 143:3007; Roberts et al.1996, AIDS Res Human Retroviruses 12:593; Quakyi et al. 1992, Scand JImmunol Suppl 11:9). The nucleic acid sequence of ORF 279 and the aminoacid sequence encoded thereby is provided in Example 1.

Example 4 Expression of ORF 576 and 576-1

The primer described in Table 1 for ORF 576 was used to locate and cloneORF 576. The predicted gene 576 was cloned in pGex vector and expressedin E. coli. The product of protein purification was analyzed bySDS-PAGE. In panel A) is shown the analysis of 576-GST fusion proteinpurification. Mice were immunized with the purified 576-GST and serawere used for Western blot (panel B), FACS analysis (panel C),bactericidal assay (panel D), and ELISA assay (panel E). Symbols: M1,molecular weight marker; TP, N. meningitidis total protein extract; OMV,N. meningitidis outer membrane vescicle preparation. Arrows indicate theposition of the main recombinant protein product (A) and the N.meningitidis immunoreactive band (B). These experiments confirm that ORF576 is a surface-exposed protein and that it is a useful immunogen. Thehydrophilicity plots, antigenic index, and amphipatic regions of ORF 576are provided in FIG. 12. The AMPHI program is used to predict putativeT-cell epitopes (Gao et al 1989, J. Immunol 143:3007; Roberts et al.1996, AIDS Res Human Retroviruses 12:593; Quakyi et al. 1992, Scand JImmunol Suppl 11:9). The nucleic acid sequence of ORF 576 and the aminoacid sequence encoded thereby is provided in Example 1.

Example 5 Expression of ORF 519 and 519-1

The primer described in Table 1 for ORF 519 was used to locate and cloneORF 519. The predicted gene 519 was cloned in pET vector and expressedin E. coli. The product of protein purification was analyzed bySDS-PAGE. In panel A) is shown the analysis of 519-His fusion proteinpurification. Mice were immunized with the purified 519-His and serawere used for Western blot (panel B), FACS analysis (panel C),bactericidal assay (panel D), and ELISA assay (panel E). Symbols: M1,molecular weight marker; TP, N. meningitidis total protein extract; OMV,N. meningitidis outer membrane vesicle preparation. Arrows indicate theposition of the main recombinant protein product (A) and the N.meningitidis immunoreactive band (B). These experiments confirm that 519is a surface-exposed protein and that it is a useful immunogen. Thehydrophilicity plots, antigenic index, and amphipatic regions of ORF 519are provided in FIG. 13. The AMPHI program is used to predict putativeT-cell epitopes (Gao et al 1989, J. Immunol 143:3007; Roberts et al.1996, AIDS Res Human Retroviruses 12:593; Quakyi et al. 1992, Scand JImmunol Suppl 11:9). The nucleic acid sequence of ORF 519 and the aminoacid sequence encoded thereby is provided in Example 1.

Example 6 Expression of ORF 121 and 121-1

The primer described in Table 1 for ORF 121 was used to locate and cloneORF 121. The predicted gene 121 was cloned in pET vector and expressedin E. coli. The product of protein purification was analyzed bySDS-PAGE. In panel A) is shown the analysis of 121-His fusion proteinpurification. Mice were immunized with the purified 121-His and serawere used for Western blot analysis (panel B), FACS analysis (panel C),bactericidal assay (panel D), and ELISA assay (panel E). Results showthat 121 is a surface-exposed protein. Symbols: M1, molecular weightmarker; TP, N. meningitidis total protein extract; OMV, N. meningitidisouter membrane vescicle preparation. Arrows indicate the position of themain recombinant protein product (A) and the N. meningitidisimmunoreactive band (B). These experiments confirm that 121 is asurface-exposed protein and that it is a useful immunogen. Thehydrophilicity plots, antigenic index, and amphipatic regions of ORF 121are provided in FIG. 14. The AMPHI program is used to predict putativeT-cell epitopes (Gao et al 1989, J. Immunol 143:3007; Roberts et al.1996, AIDS Res Human Retroviruses 12:593; Quakyi et al. 1992, Scand JImmunol Suppl 11:9). The nucleic acid sequence of ORF 121 and the aminoacid sequence encoded thereby is provided in Example 1.

Example 7 Expression of ORF 128 and 128-1

The primer described in Table 1 for ORF 128 was used to locate and cloneORF 128. The predicted gene 128 was cloned in pET vector and expressedin E. coli. The product of protein purification was analyzed bySDS-PAGE. In panel A) is shown the analysis of 128-His purification.Mice were immunized with the purified 128-His and sera were used forWestern blot analysis (panel B), FACS analysis (panel C), bactericidalassay (panel D) and ELISA assay (panel E). Results show that 128 is asurface-exposed protein. Symbols: M1, molecular weight marker; TP, N.meningitidis total protein extract; OMV, N. meningitidis outer membranevesicle preparation. Arrows indicate the position of the mainrecombinant protein product (A) and the N. meningitidis immunoreactiveband (B). These experiments confirm that 128 is a surface-exposedprotein and that it is a useful immunogen. The hydrophilicity plots,antigenic index, and amphipatic regions of ORF 128 are provided in FIG.15. The AMPHI program is used to predict putative T-cell epitopes (Gaoet al 1989, J. Immunol 143:3007; Roberts et al. 1996, AIDS Res HumanRetroviruses 12:593; Quakyi et al. 1992, Scand J Immunol Suppl 11:9).The nucleic acid sequence of ORF 128 and the amino acid sequence encodedthereby is provided in Example 1.

Example 8 Expression of ORF 206

The primer described in Table 1 for ORF 206 was used to locate and cloneORF 206. The predicted gene 206 was cloned in pET vector and expressedin E. coli. The product of protein purification was analyzed bySDS-PAGE. In panel A) is shown the analysis of 206-His purification.Mice were immunized with the purified 206-His and sera were used forWestern blot analysis (panel B). It is worthnoting that theimmunoreactive band in protein extracts from meningococcus is 38 kDainstead of 17 kDa (panel A). To gain information on the nature of thisantibody staining we expressed ORF 206 in E. coli without the His-tagand including the predicted leader peptide. Western blot analysis ontotal protein extracts from E. coli expressing this native form of the206 protein showed a recative band at a position of 38 kDa, as observedin meningococcus. We conclude that the 38 kDa band in panel B) isspecific and that anti-206 antibodies, likely recognize a multimericprotein complex. In panel C is shown the FACS analysis, in panel D thebactericidal assay, and in panel E) the ELISA assay. Results show that206 is a surface-exposed protein. Symbols: M1, molecular weight marker;TP, N. meningitidis total protein extract; OMV, N. meningitidis outermembrane vesicle preparation. Arrows indicate the position of the mainrecombinant protein product (A) and the N. meningitidis immunoreactiveband (B). These experiments confirm that 206 is a surface-exposedprotein and that it is a useful immunogen. The hydrophilicity plots,antigenic index, and amphipatic regions of ORF 519 are provided in FIG.16. The AMPHI program is used to predict putative T-cell epitopes (Gaoet al 1989, J. Immunol 143:3007; Roberts et al. 1996, AIDS Res HumanRetroviruses 12:593; Quakyi et al. 1992, Scand J Immunol Suppl 11:9).The nucleic acid sequence of ORF 206 and the amino acid sequence encodedthereby is provided in Example 1.

Example 9 Expression of ORF 287

The primer described in Table 1 for ORF 287 was used to locate and cloneORF 287. The predicted gene 287 was cloned in pGex vector and expressedin E. coli. The product of protein purification was analyzed bySDS-PAGE. In panel A) is shown the analysis of 287-GST fusion proteinpurification. Mice were immunized with the purified 287-GST and serawere used for FACS analysis (panel B), bactericidal assay (panel C), andELISA assay (panel D). Results show that 287 is a surface-exposedprotein. Symbols: M1, molecular weight marker. Arrow indicates theposition of the main recombinant protein product (A). These experimentsconfirm that 287 is a surface-exposed protein and that it is a usefulimmunogen. The hydrophilicity plots, antigenic index, and amphipaticregions of ORF 287 are provided in FIG. 17. The AMPHI program is used topredict putative T-cell epitopes (Gao et al 1989, J. Immunol 143:3007;Roberts et al. 1996, AIDS Res Human Retroviruses 12:593; Quakyi et al.1992, Scand J Immunol Suppl 11:9). The nucleic acid sequence of ORF 287and the amino acid sequence encoded thereby is provided in Example 1.

Example 10 Expression of ORF 406

The primer described in Table 1 for ORF 406 was used to locate and cloneORF 406. The predicted gene 406 was cloned in pET vector and expressedin E. coli. The product of protein purification was analyzed bySDS-PAGE. In panel A) is shown the analysis of 406-His fusion proteinpurification. Mice were immunized with the purified 406-His and serawere used for Western blot analysis (panel B), FACS analysis (panel C),bactericidal assay (panel D), and ELISA assay (panel E). Results showthat 406 is a surface-exposed protein. Symbols: M1, molecular weightmarker; TP, N. meningitidis total protein extract; OMV, N. meningitidisouter membrane vescicle preparation. Arrows indicate the position of themain recombinant protein product (A) and the N. meningitidisimmunoreactive band (B). These experiments confirm that 406 is asurface-exposed protein and that it is a useful immunogen. Thehydrophilicity plots, antigenic index, and amphipatic regions of ORF 406are provided in FIG. 18. The AMPHI program is used to predict putativeT-cell epitopes (Gao et al 1989, J. Immunol 143:3007; Roberts et al.1996, AIDS Res Human Retroviruses 12:593; Quakyi et al. 1992, Scand JImmunol Suppl 11:9). The nucleic acid sequence of ORF 406 and the aminoacid sequence encoded thereby is provided in Example 1.

Example 11

Table 2 lists several Neisseria strains which were used to assess theconservation of the sequence of ORF 225 among different strains.

TABLE 2 225 gene variability: List of used Neisseria strainsIdentification number Strains Source/reference Group B zo01_225 NG6/88R. Moxon/Seiler et al., 1996 zo02_225 BZ198 R. Moxon/Seiler et al., 1996zo03_225 NG3/88 R. Moxon/Seiler et al., 1996 zo04_225 297-0 R.Moxon/Seiler et al., 1996 zo05_225  1000 R. Moxon/Seiler et al., 1996zo06_225 BZ147 R. Moxon/Seiler et al., 1996 zo07_225 BZ169 R.Moxon/Seiler et al., 1996 zo08_225   528 R. Moxon/Seiler et al., 1996zo09_225 NGP165 R. Moxon/Seiler et al., 1996 zo10_225 BZ133 R.Moxon/Seiler et al., 1996 zo11_225 NGE31 R. Moxon/Seiler et al., 1996zo12_225 NGF26 R. Moxon/Seiler et al., 1996 zo13_225 NGE28 R.Moxon/Seiler et al., 1996 zo14_225 NGH38 R. Moxon/Seiler et al., 1996zo15_225 SWZ107 R. Moxon/Seiler et al., 1996 zo16_225 NGH15 R.Moxon/Seiler et al., 1996 zo17_225 NGH36 R. Moxon/Seiler et al., 1996zo18_225 BZ232 R. Moxon/Seiler et al., 1996 zo19_225 BZ83 R.Moxon/Seiler et al., 1996 zo20_225 44/76 R. Moxon/Seiler et al., 1996zo21_225 MC58 R. Moxon zo96_225  2996 Our collection Group A zo22_225205900 R. Moxon zo23_225 F6124 R. Moxon z2491 Z2491 R. Moxon/Maiden etal., 1998 Group C zo24_225 90/18311 R. Moxon zo25_225 93/4286 R. MoxonOthers zo26_225 A22 (group W) R. Moxon/Maiden et al., 1998 zo27_225 E26(group X) R. Moxon/Maiden et al., 1998 zo28_225 860800 (group Y) R.Moxon/Maiden et al., 1998 zo29_225 E32 (group Z) R. Moxon/Maiden et al.,1998 Gonococcus zo32_225 Ng F62 R. Moxon/Maiden et al., 1998 zo33_225 NgSN4 R. Moxon fa1090 FA1090 R. Moxon References: Seiler A. et al., Mol.Microbiol., 1996, 19(4): 841-856. Maiden et al., Proc. Natl. Acad. Sci.USA, 1998, 95: 3140-3145.

The amino acid sequences for each listed strain are as follows:

>FA1090 <SEQ ID 3115> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPVNRAPARRAGNADELIGSAMGLNEQPVLPVNRAPARRAGNADELIGSAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGAPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFLN* Z2491 <SEQ ID 3116>MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFLN* ZO01_225 <SEQ ID 3117>MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO02_225 <SEQ ID3118> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO03_225 <SEQ ID3119> MDSFFKPAVWAVLWLMFAVRLALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO04_225 <SEQ ID3120> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO05_225 <SEQ ID3121> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGSAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO06_225 <SEQ ID3122> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO07_225 <SEQ ID3123> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO08_225 <SEQ ID3124> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGSAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO09_225 <SEQ ID3125> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO10_225 <SEQ ID3126> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO11_225 <SEQ ID3127> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFLN* ZO12_225 <SEQ ID 3128>MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO13_225 <SEQ ID3129> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPVNRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFIQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO14_225 <SEQ ID3130> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO15_225 <SEQ ID3131> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFLN* ZO16_225 <SEQ ID 3132>MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO17_225 <SEQ ID3133> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO18_225 <SEQ ID3134> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO19_225 <SEQ ID3135> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO20_225 <SEQ ID3136> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFLN* ZO21_225 <SEQ ID 3137>MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO22_225 <SEQ ID3138> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO23_225 <SEQ ID3139> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO24_225 <SEQ ID3140> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO25_225 <SEQ ID3141> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO26_225 <SEQ ID3142> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO27_225 <SEQ ID3143> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO28_225 <SEQ ID3144> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO29_225 <SEQ ID3145> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N* ZO32_225 <SEQ ID3146> MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPVNRAPARRAGNADELIGSAMGLNEQPVLPVNRAPARRAGNADELIGSAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGAPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFLN* ZO33_225 <SEQ ID 3147>MDSFFKPAVWAVLWLMFAVRSALADELTNLLSSREQILRQFAEDEQPVLPVNRAPARRAGNADELIGSAMGLNEQPVLPVNRAPARRAGNADELIGSAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGAPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRIKKNDPSRFLN* ZO96_225 <SEQ ID 3148>MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAGNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFL N*

FIG. 19 shows the results of aligning the sequences of each of thesestrains. Dark shading indicates regions of homology, and gray shadingindicates the conservation of amino acids with similar characteristics.As is readily discernible, there is significant conservation among thevarious strains of ORF 225, further confirming its utility as an antigenfor both vaccines and diagnostics.

Example 12

Table 3 lists several Neisseria strains which were used to assess theconservation of the sequence of ORF 235 among different strains.

TABLE 3 235 gene variability: List of used Neisseria strainsIdentification number Strains Reference Group B gnmzq01 NG6/88 Seiler etal., 1996 gnmzq02 BZ198 Seiler et al., 1996 gnmzq03 NG3/88 Seiler etal., 1996 gnmzq04  1000 Seiler et al., 1996 gnmzq05  1000 Seiler et al.,1996 gnmzq07 BZ169 Seiler et al., 1996 gnmzq08   528 Seiler et al., 1996gnmzq09 NGP165 Seiler et al., 1996 gnmzq10 BZ133 Seiler et al., 1996gnmzq11 NGE31 Seiler et al., 1996 gnmzq13 NGE28 Seiler et al., 1996gnmzq14 NGH38 Seiler et al., 1996 gnmzq15 SWZ107 Seiler et al., 1996gnmzq16 NGH15 Seiler et al., 1996 gnmzq17 NGH36 Seiler et al., 1996gnmzq18 BZ232 Seiler et al., 1996 gnmzq19 BZ83 Seiler et al., 1996gnmzq21 MC58 Virji et al., 1992 Group A gnmzq22 205900 Our collectiongnmzq23 F6124 Our collection z2491 Z2491 Maiden et al., 1998 Group Cgnmzq24 90/18311 Our collection gnmzq25 93/4286 Our collection Othersgnmzq26 A22 (group W) Maiden et al., 1998 gnmzq27 E26 (group X) Maidenet al., 1998 gnmzq28 860800 (group Y) Maiden et al., 1998 gnmzq29 E32(group Z) Maiden et al., 1998 gnmzq31 N. lactamica Our collectionGonococcus gnmzq32 Ng F62 Maiden et al., 1998 gnmzq33 Ng SN4 Ourcollection fa1090 FA1090 Dempsey et al. 1991 References: Seiler A. etal., Mol. Microbiol., 1996, 19(4): 841-856. Maiden R. et al., Proc.Natl. Acad. Sci. USA, 1998, 95: 3140-3145. Virji M. et al., Mol.Microbiol., 1992, 6: 1271-1279 Dempsey J. F. et al., J. Bacteriol.,1991, 173: 5476-5486

The amino acid sequences for each listed strain are as follows:

FA1090 <SEQ ID 3149> MKPLILGLAAVLALSACQVRKAPDLDYTSFKESKPASILVVPPLNESPDVNGTWGMLASTAAPISEAGYYVFPAAVVEETFKENGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVGAVVNQIANSLTDRGYQVSKTAAYNLLSPYSR NGILKGPRFVEEQPK*GNMZQ01 <SEQ ID 3150> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKENGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANNLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ02 <SEQ ID 3151> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ03 <SEQ ID 3152> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ04 <SEQ ID 3153> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ05 <SEQ ID 3154> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKENGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANNLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ07 <SEQ ID 3155> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ08 <SEQ ID 3156> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKENGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANNLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ09 <SEQ ID 3157> MKPLILGLAAALVLSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGMLASTAEPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVQPEKLHQIFGNDAVLYITITEYGTSYQILDSVTTVSARARLVDSRNGKVLWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ10 <SEQ ID 3158> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ11 <SEQ ID 3159> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ13 <SEQ ID 3160> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ14 <SEQ ID 3161> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVGAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ15 <SEQ ID 3162> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ16 <SEQ ID 3163> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ17 <SEQ ID 3164> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ18 <SEQ ID 3165> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVGAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ19 <SEQ ID 3166> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ21 <SEQ ID 3166> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ22 <SEQ ID 3167> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ23 <SEQ ID 3168> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ24 <SEQ ID 3169> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ25 <SEQ ID 3170> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ26 <SEQ ID 3171> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGMLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVGAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ27 <SEQ ID 3172> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ28 <SEQ ID 3173> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ29 <SEQ ID 3174> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*GNMZQ31 <SEQ ID 3175> MKPLILGLAAVLALSACQVQKAPDFDYTAFKESKPASILVVPPLNESPDVNGTWGMLASTAEPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITITEYGTSYQILDSVTTVSARARLVDSRNGKVLWSGSASIREGSNNSNSGLLGALVGAVVNQIANSLTDRGYQVSKAAAYDLLSPYSH NGILKGPRFVEEQPK*GNMZQ32 <SEQ ID 3176> MKPLILGLAAVLALSACQVRKAPDLDYTSFKESKPASILVVPPLNESPDVNGTWGMLASTAAPISEAGYYVFPAAVVEETFKENGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVGAVVNQIANSLTDRGYQVSKTAAYNLLSPYSR NGILKGPRFVEEQPK*GNMZQ33 <SEQ ID 3177> MKPLILGLAAVLALSACQVRKAPDLDYTSFKESKPASILVVPPLNESPDVNGTWGMLASTAAPISEAGYYVFPAAVVEETFKENGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVGAVVNQIANSLTDRGYQVSKTAAYNLLSPYSR NGILKGPRFVEEQPK*Z2491 <SEQ ID 3178> MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLTDRGYQVSKTAAYNLLSPYSH NGILKGPRFVEEQPK*

FIG. 20 shows the results of aligning the sequences of each of thesestrains. Dark shading indicates regions of homology, and gray shadingindicates the conservation of amino acids with similar characteristics.As is readily discernible, there is significant conservation among thevarious strains of ORF 235, further confirming its utility as an antigenfor both vaccines and diagnostics.

Example 13

Table 4 lists several Neisseria strains which were used to assess theconservation of the sequence of ORF 287 among different strains.

TABLE 4 287 gene variability: List of used Neisseria strainsIdentification number Strains Reference Group B 287_2 BZ198 Seiler etal., 1996 287_9 NGP165 Seiler et al., 1996 287_14 NGH38 Seiler et al.,1996 287_21 MC58 Virji et al., 1992 Group A z2491 Z2491 Maiden et al.,1998 Gonococcus fa1090 FA1090 Dempsey et al. 1991 References: Seiler A.et al., Mol. Microbiol., 1996, 19(4): 841-856. Maiden R. et al., Proc.Natl. Acad. Sci. USA, 1998, 95: 3140-3145. Virji M. et al., Mol.Microbiol., 1992, 6: 1271-1279 Dempsey J. F. et al., J. Bacteriol.,1991, 173: 5476-5486

The amino acid sequences for each listed strain are as follows:

287_14 <SEQ ID 3179> MFKRSVIAMACIFALSACGGGGGGSPDVKSADTLSKPAAPVVSEKETEAKEDAPQAGSQGQGAPSAQGGQDMAAVSEENTGNGGAAATDKPKNEDEGAQNDMPQNAADTDSLTPNHTPASNMPAGNMENQAPDAGESEQPANQPDMANTADGMQGDDPSAGGENAGNTAAQGTNQAENNQTAGSQNPASSTNPSATNSGGDFGRTNVGNSVVIDGPSQNITLTHCKGDSCSGNNFLDEEVQLKSEFEKLSDADKISNYKKDGKNDGKNDKFVGLVADSVQMKGINQYIIFYKPKPTSFARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRYLTYGAEKLPGGSYALRVQGEPSKGEMLAGTAVYNGEVLHFHTENGRPSPSRGRFAAKVDFGSKSVDGIIDSGDGLHMGTQKFKAAIDGNGFKGTWTENGGGDVSGKFYGPAGEEVAGKYSYRPTDAEKGGFGVFAGKKEQD* 287_2 <SEQ ID 3180>MFKRSVIAMACIFALSACGGGGGGSPDVKSADTLSKPAAPVVSEKETEAKEDAPQAGSQGQGAPSAQGGQDMAAVSEENTGNGGAAATDKPKNEDEGAQNDMPQNAADTDSLTPNHTPASNMPAGNMENQAPDAGESEQPANQPDMANTADGMQGDDPSAGGENAGNTAAQGTNQAENNQTAGSQNPASSTNPSATNSGGDFGRTNVGNSVVIDGPSQNITLTHCKGDSCSGNNFLDEEVQLKSEFEKLSDADKISNYKKDGKNDGKNDKFVGLVADSVQMKGINQYIIFYKPKPTSFARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRYLTYGAEKLPGGSYALRVQGEPSKGEMLAGTAVYNGEVLHFHTENGRPSPSRGRFAAKVDFGSKSVDGIIDSGDGLHMGTQKFKAAIDGNGFKGTWTENGGGDVSGKFYGPAGEEVAGKYSYRPTDAEKGGFGVFAGKKEQD* 287_21. <SEQ ID 3181>MFKRSVIAMACIFALSACGGGGGGSPDVKSADTLSKPAAPVVSEKETEAKEDAPQAGSQGQGAPSAQGSQDMAAVSEENTGNGGAVTADNPKNEDEVAQNDMPQNAAGTDSSTPNHTPDPNMLAGNMENQATDAGESSQPANQPDMANAADGMQGDDPSAGGQNAGNTAAQGANQAGNNQAAGSSDPIPASNPAPANGGSNFGRVDLANGVLIDGPSQNITLTHCKGDSCSGNNFLDEEVQLKSEFEKLSDADKISNYKKDGKNDKFVGLVADSVQMKGINQYIIFYKPKPTSFARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRYLTYGAEKLPGGSYALRVQGEPAKGEMLAGAAVYNGEVLHFHTENGRPYPTRGRFAAKVDFGSKSVDGIIDSGDDLHMGTQKFKAAIDGNGFKGTWTENGSGDVSGKFYGPAGEEVAGKYSYRPTDAEKGGFGVFAGKKEQD* 287_9 <SEQ ID 3182>MFKRSVIAMACIVALSACGGGGGGSPDVKSADTLSKPAAPVVTEDVGEEVLPKEKKDEEAVSGAPQADTQDATAGKGGQDMAAVSAENTGNGGAATTDNPENKDEGPQNDMPQNAADTDSSTPNHTPAPNMPTRDMGNQAPDAGESAQPANQPDMANAADGMQGDDPSAGENAGNTADQAANQAENNQVGGSQNPASSTNPNATNGGSDFGRINVANGIKLDSGSENVTLTHCKDKVCDRDFLDEEAPPKSEFEKLSDEEKINKYKKDEQRENFVGLVADRVEKNGTNKYVIIYKDKSASSSSARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRYLTYGAEKLSGGSYALSVQGEPAKGEMLAGTAVYNGEVLHFHMENGRPSPSGGRFAAKVDFGSKSVDGIIDSGDDLHMGTQKFKAVIDGNGFKGTWTENGGGDVSGRFYGPAGEEVAGKYSYRPTDAEKGGFGVFAGKKEQD* FA1090 <SEQ ID 3183>MFKRSVIAMACIFPLSACGGGGGGSPDVKSADTPSKPAAPVVAENAGEGVLPKEKKDEEAAGGAPQADTQDATAGEGSQDMAAVSAENTGNGGAATTDNPKNEDAGAQNDMPQNAAESANQTGNNQPAGSSDSAPASNPAPANGGSDFGRTNVGNSVVIDGPSQNITLTHCKGDSCNGDNLLDEEAPSKSEFEKLSDEEKIKRYKKDEQRENFVGLVADRVKKDGTNKYIIFYTDKPPTRSARSRRSLPAEIPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRYLTYGAEKLPGGSYALRVQGEPAKGEMLVGTAVYNGEVLHFHMENGRPYPSGGRFAAKVDFGSKSVDGIIDSGDDLHMGTQKFKAAIDGNGFKGTWTENGGGDVSGRFYGPAGEEVAGKYSYRPTDAEKGGFGVFAGKKDRD* Z2491 <SEQ ID 3184>MFKRSVIAMACIFALSACGGGGGGSPDVKSADTLSKPAAPVVSEKETEAKEDAPQAGSQGQGAPSAQGSQDMAAVSEENTGNGGAVTADNPKNEDEVAQNDMPQNAAGTDSSTPNHTPDPNMLAGNMENQATDAGESSQPANQPDMANAADGMQGDDPSAGGQNAGNTAAQGANQAGNNQAAGSSDPIPASNPAPANGGSNFGRVDLANGVLIDGPSQNITLTHCKGDSCSGNNFLDEEVQLKSEFEKLSDADKISNYKKDGKNDKFVGLVADSVQMKGINQYIIFYKPKPTSFARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRYLTYGAEKLPGGSYALRVQGEPAKGEMLAGAAVYNGEVLHFHTENGRPYPTRGRFAAKVDFGSKSVDGIIDSGDDLHMGTQKFKAAIDGNGFKGTWTENGSGDVSGKFYGPAGEEVAGKYSYRPTDAEKGGFGVFAGKKEQD*

FIG. 21 shows the results of aligning the sequences of each of thesestrains. Dark shading indicates regions of homology, and gray shadingindicates the conservation of amino acids with similar characteristics.As is readily discernible, there is significant conservation among thevarious strains of ORF 225, further confirming its utility as an antigenfor both vaccines and diagnostics.

Example 14

Table 5 lists several Neisseria strains which were used to assess theconservation of the sequence of ORF 519 among different strains.

TABLE 5 519 gene variability: List of used Neisseria strainsIdentification number Strains Source/reference Group B zv01_519 NG6/88R. Moxon/Seiler et al., 1996 zv02_519 BZ198 R. Moxon/Seiler et al., 1996zv03_519ass NG3/88 R. Moxon/Seiler et al., 1996 zv04_519 297-0 R.Moxon/Seiler et al., 1996 zv05_519  1000 R. Moxon/Seiler et al., 1996zv06_519ass BZ147 R. Moxon/Seiler et al., 1996 zv07_519 BZ169 R.Moxon/Seiler et al., 1996 zv11_519 NGE31 R. Moxon/Seiler et al., 1996zv12_519 NGF26 R. Moxon/Seiler et al., 1996 zv18_519 BZ232 R.Moxon/Seiler et al., 1996 zv19_519 BZ83 R. Moxon/Seiler et al., 1996zv20_519ass 44/76 R. Moxon/Seiler et al., 1996 zv21_519ass MC58 R. Moxonzv96_519  2996 Our collection Group A zv22_519ass 205900 R. Moxonz2491_519 Z2491 R. Moxon/Maiden et al., 1998 Others zv26_519 A22 (groupW) R. Moxon/Maiden et al., 1998 zv27_519 E26 (group X) R. Moxon/Maidenet al., 1998 zv28_519 860800 (group Y) R. Moxon/Maiden et al., 1998zv29_519ass E32 (group Z) R. Moxon/Maiden et al., 1998 Gonococcuszv32_519 Ng F62 R. Moxon/Maiden et al., 1998 fa1090_519 FA1090 R. MoxonReferences: Seiler A. et al., Mol. Microbiol., 1996, 19(4): 841-856.Maiden et al., Proc. Natl. Acad. Sci. USA, 1998, 95: 3140-3145.

The amino acid sequences for each listed strain are as follows:

FA1090_519 <SEQ ID 3185>MEFFIILLAAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRAMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*Z2491_519 <SEQ ID 3186>MEFFIILLAAVVVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV01_519 <SEQ ID 3187>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV02_519 <SEQ ID 3188>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV03_519 <SEQ ID 3189>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV04_519 <SEQ ID 3190>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV05_519 <SEQ ID 3191>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV06_519ASS <SEQ ID 3192>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVFSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAERKKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV07_519 <SEQ ID 3193>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV11_519 <SEQ ID 3194>MEFFIILLAAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV12_519 <SEQ ID 3195>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV18_519 <SEQ ID 3196>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV19_519 <SEQ ID 3197>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV20_519ASS <SEQ ID 3198>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSM ISAGMKIIDSSKTAK*ZV21_519ASS <SEQ ID 3199>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV22_519ASS <SEQ ID 3200>MEFFIILLAAVVVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAKIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV26_519 <SEQ ID 3201>MEFFIILLAAVVVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV27_519 <SEQ ID 3202>MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV28_519 <SEQ ID 3203>MEFFIILLAAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV29_519ASS <SEQ ID 3204>MEFFIILLAAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSIVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREPEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSNKTAK*ZV32_519 <SEQ ID 3205>MEFFIILLAAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRAMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*ZV96_519 <SEQ ID 3206>MEFFIILLAAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSLKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL ISAGMKIIDSSKTAK*

FIG. 22 shows the results of aligning the sequences of each of thesestrains. Dark shading indicates regions of homology, and gray shadingindicates the conservation of amino acids with similar characteristics.As is readily discernible, there is significant conservation among thevarious strains of ORF 225, further confirming its utility as an antigenfor both vaccines and diagnostics.

Example 15

Table 6 lists several Neisseria strains which were used to assess theconservation of the sequence of ORF 919 among different strains.

TABLE 6 919 gene variability: List of used Neisseria strainsIdentification number Strains Source/reference Group B zm01 NG6/88 R.Moxon/Seiler et al., 1996 zm02 BZ198 R. Moxon/Seiler et al., 1996 zm03NG3/88 R. Moxon/Seiler et al., 1996 zm04 297-0 R. Moxon/Seiler et al.,1996 zm05  1000 R. Moxon/Seiler et al., 1996 zm06 BZ147 R. Moxon/Seileret al., 1996 zm07 BZ169 R. Moxon/Seiler et al., 1996 zm08n   528 R.Moxon/Seiler et al., 1996 zm09 NGP165 R. Moxon/Seiler et al., 1996 zm10BZ133 R. Moxon/Seiler et al., 1996 zm11asbc NGE31 R. Moxon/Seiler etal., 1996 zm12 NGF26 R. Moxon/Seiler et al., 1996 zm13 NGE28 R.Moxon/Seiler et al., 1996 zm14 NGH38 R. Moxon/Seiler et al., 1996 zm15SWZ107 R. Moxon/Seiler et al., 1996 zm16 NGH15 R. Moxon/Seiler et al.,1996 zm17 NGH36 R. Moxon/Seiler et al., 1996 zm18 BZ232 R. Moxon/Seileret al., 1996 zm19 BZ83 R. Moxon/Seiler et al., 1996 zm20 44/76 R.Moxon/Seiler et al., 1996 zm21 MC58 R. Moxon zm96  2996 Our collectionGroup A zm22 205900 R. Moxon zm23asbc F6124 R. Moxon z2491 Z2491 R.Moxon/Maiden et al., 1998 Group C zm24 90/18311 R. Moxon zm25 93/4286 R.Moxon Others zm26 A22 (group W) R. Moxon/Maiden et al., 1998 zm27bc E26(group X) R. Moxon/Maiden et al., 1998 zm28 860800 (group Y) R.Moxon/Maiden et al., 1998 zm29asbc E32 (group Z) R. Moxon/Maiden et al.,1998 zm31asbc N. lactamica R. Moxon Gonococcus zm32asbc Ng F62 R.Moxon/Maiden et al., 1998 zm33asbc Ng SN4 R. Moxon fa1090 FA1090 R.Moxon References: Seiler A. et al., Mol. Microbiol., 1996, 19(4):841-856. Maiden et al., Proc. Natl. Acad. Sci. USA, 1998, 95: 3140-3145.

The amino acid sequences for each listed strain are as follows:

FA1090 <SEQ ID 3207> MKKHLLRSALYGIAAAILAACQSRSIQTFPQPDTSVINGPDRPAGIPDPAGTTVAGGGAVYTVVPHLSMPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKRFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDGRRTERARFPIYGIPDDFISVPLPAGLRGGKNLVRIRQTGKNSGTIDNAGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKAYMRQNPQRLAEVLGQNPSYIFFRELAGSGNEGPVGALGTPLMGEYAGAIDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* Z2491 <SEQ ID 3208>MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSVQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKAYMQQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM01 <SEQ ID 3209>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM02 <SEQ ID 3210>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM03 <SEQ ID 3211>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM04 <SEQ ID 3212>MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPAPAGTTVAGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNAGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKAYMQQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM05 <SEQ ID 3213>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLSCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKAYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM06 <SEQ ID 3214>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM07 <SEQ ID 3215>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM08N <SEQ ID 3216>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKAYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM09 <SEQ ID 3217>MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPAPAGTTVAGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSGNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM10 <SEQ ID 3218>MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPAPAGTTVAGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSGNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM11ASBC <SEQ ID 3219>MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPAPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSVQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNAGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM12 <SEQ ID 3220>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM13 <SEQ ID 3221>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAEQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKAYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM14 <SEQ ID 3222>MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPAPAGTTVAGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNAGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSRNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM15 <SEQ ID 3223>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDLAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNHQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSGNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM16 <SEQ ID 3224>MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPGRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM17 <SEQ ID 3225>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM18 <SEQ ID 3226>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM19 <SEQ ID 3227>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM20 <SEQ ID 3228>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM21 <SEQ ID 3229>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM22 <SEQ ID 3230>MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSVQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKAYMQQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM23ASBC <SEQ ID 3231>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNAGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTSKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGETAGKMKEPGYVWQLLPNGMKPEYRP* ZM24 <SEQ ID 3232>MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPAPAGTTVAGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSGNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM25 <SEQ ID 3233>MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPAPAGTTVAGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGKYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSGNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM26 <SEQ ID 3234>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSVQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKAYMQQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM27BC <SEQ ID 3235>MKKYLFRAALYGISAAILAACQSKSIQTFPQPDTSVINGPDRPAGIPDPAGTTVAGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNAGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGETAGKMKEPGYVWQLLPNGMKPEYRP* ZM28 <SEQ ID 3236>MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKAYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM29ASBC <SEQ ID 3237>MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELTGSGNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATTHPITRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM31ASBC <SEQ ID 3238>MKKHLFRAALYGIAAAILAACQSKSIQTFPQPDTSIIKGPDRPAGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNAGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKAYMRQNPQRLAEVLGQNPSYVFFRELAGSGNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM32ASBC <SEQ ID 3239>MKKHLLRSALYGIAAAILAACQSRSIQTFPQPDTSVINGPDRPAGIPDPAGTTVAGGGAVYTVVPHLSMPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKRFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDGRRTERARFPIYGIPDDFISVPLPAGLRGGKALVRIRQTGKNSGTIDNAGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKAYMRQNPQRLAEVLGQNPSYIFFRELAGSGGDGPVGALGTPLMGGYAGAIDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM33ASBC <SEQ ID 3240>MKKHLLRSALYGIAAAILAACQSRSIQTFPQPDTSVINGPDRPAGIPDPAGTTVAGGGAVYTVVPHLSMPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPIHSFQAKRFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDGRRTERARFPIYGIPDDFISVPLPAGLRGGKNLVRIRQTGKNSGTIDNAGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPHKLAEVLGQNPSYIFFRELAGSGNEGPVGALGTPLMGEYAGAIDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP* ZM96 <SEQ ID 3241>MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKAYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP*

FIG. 23 shows the results of aligning the sequences of each of thesestrains. Dark shading indicates regions of homology, and gray shadingindicates the conservation of amino acids with similar characteristics.As is readily discernible, there is significant conservation among thevarious strains of ORF 225, further confirming its utility as an antigenfor both vaccines and diagnostics.

Example 16

Using the above-described procedures, the following oligonucleotideprimers were employed in the polymerase chain reaction (PCR) assay inorder to clone the ORFs as indicated:

TABLE 7 Oligonucleotides used for PCR to amplify complete or partialORFs Restriction ORF primer Sequence sites 001 ForwardCGCGGATCCCATATG-TGGATGGTGCTGGTCAT BamHI- NdeI ReverseCCCGCTCGAG-TGCCGTCTTGTCCCAC XhoI 003 ForwardCGCGGATCCCATATG-GTCGTATTCGTGGC BamHI- NdeI ReverseCCCGCTCGAG-AAAATCATGAACACGCGC XhoI 005 ForwardCGCGGATCCCATATG-GACAATATTGACATGT BamHI- NdeI ReverseCCCGCTCGAG-CATCACATCCGCCCG XhoI 006 ForwardCGCGGATCCCATATG-CTGCTGGTGCTGG BamHI- NdeI ReverseCCCGCTCGAG-AGTTCCGGCTTTGATGT XhoI 007 ForwardCGCGGATCCCATATG-GCCGACAACAGCATCAT BamHI- NdeI ReverseCCCGCTCGAG-AAGGCGTTCATGATATAAG XhoI 008 ForwardCGCGGATCCCATATG-AACAACAGACATTTTG BamHI- NdeI ReverseCCCGCTCGAG-CCTGTCCGGTAAAAGAC XhoI 009 ForwardCGCGGATCCCATATG-CCCCGCGCTGCT BamHI- NdeI ReverseCCCGCTCGAG-TGGCTTTTGCCACGTTTT XhoI 011 ForwardCGCGGATCCCATATG-AAGACACACCGCAAG BamHI- NdeI ReverseCCCGCTCGAG-GGCGGTCAGTACGGT XhoI 012 ForwardCGCGGATCCCATATG-CTCGCCCGTTGCC BamHI- NdeI ReverseCCCGCTCGAG-AGCGGGGAAGAGGCAC XhoI 013 ForwardCGCGGATCCCATATG-CCTTTGACCATGCT BamHI- NdeI ReverseCCCGCTCGAG-CTGATTCGGCAAAAAAATCT XhoI 018 ForwardCGCGGATCCCATATG-CAGCAGAGGCAGTT BamHI- NdeI ReverseCCCGCTCGAG-GACGAGGCGAACGCC XhoI 019 ForwardAAAGAATTC-CTGCCAGCCGGCAAGACCCCGGC Eco RI ReverseAAACTGCAG-TCAGCGGGCGGGGACAATGCCCAT Pst I 023 ForwardAAAGAATTC-AAAGAATATTCGGCATGGCAGGC Eco RI ReverseAAACTGCAG-TTACCCCCAAATCACTTTAACTGA Pst I 025 ForwardAAAGAATTC-TGCGCCACCCAACAGCCTGCTCC Eco RI ReverseAAACTGCAG-TCAGAACGCGATATAGCTGTTCGG Pst I 031 ForwardCGCGGATCCCATATG-GTCTCCCTTCGCTT BamHI- NdeI ReverseCCCGCTCGAG-ATGTAAGACGGGGACAAC XhoI 032 ForwardCGCGGATCCCATATG-CGGCGAAACGTGC BamHI- NdeI ReverseCCCGCTCGAG-CTGGTTTTTTGATATTTGTG XhoI 033 ForwardCGCGGATCCCATATG-GCGGCGGCAGACA BamHI- NdeI ReverseCCCGCTCGAG-ATTTGCCGCATCCCGAT XhoI 034 ForwardCGCGGATCCCATATG-GCCGAAAACAGCTACGG BamHI- NdeI ReverseCCCGCTCGAG-TTTGACGATTTGGTTCAATT XhoI 036 ForwardCGCGGATCCCATATG-CTGAAGCCGTGCG BamHI- NdeI ReverseCCCGCTCGAG-CCGGACTGCGTATCGG XhoI 038 ForwardCGCGGATCCCATATG-ACCGATTTCCGCCA BamHI- NdeI ReverseCCCGCTCGAG-TTCTACGCCGTACTGCC XhoI 039 ForwardCGCGGATCCCATATG-CCGTCCGAACCGC BamHI- NdeI ReverseCCCGCTCGAG-TAGGATGACGAGGTAGG XhoI 041 ForwardCGCGGATCCCATATG-TTCGTGCGCGAACCGC BamHI- NdeI ReverseCCCGCTCGAG-GCCCAAAAACTCTTTCAAA XhoI 042 ForwardCGCGGATCCCATATG-ACGATGATTTGCTTGC BamHI- NdeI ReverseCCCGCTCGAG-TTTGCAGCCTGCATTTGAC XhoI 043 ForwardAAAAAAGGTACC-ATGGTTGTTTCAAATCAAAATATC Kpn I ReverseAAACTGCAG-TTATTGCGCTTCACCTTCCGCCGC Pst I 043a ForwardAAAAAAGGTACC-GCAAAAGTGCATGGCGGCTTGGACGGTGC Kpn I Reverse AAAAAACTGCAG-Pst I TTAATCCTGCAACACGAATTCGCCCGTCCG 044 ForwardCGCGGATCCCATATG-CCGTCCGACTAGAG BamHI- NdeI ReverseCCCGCTCGAG-ATGCGCTACGGTAGCCA XhoI 046 ForwardAAAGAATTC-ATGTCGGCAATGCTCCCGACAAG Eco RI ReverseAAACTGCAG-TCACTCGGCGACCCACACCGTGAA Pst I 047 ForwardCGCGGATCCCATATG-GTCATCATACAGGCG BamHI- NdeI ReverseCCCGCTCGAG-TCCGAAAAAGCCCATTTTG XhoI 048 ForwardAAAGAATTC-ATGCTCAACAAAGGCGAAGAATTGCC Eco RI ReverseAAACTGCAG-TCAAGATTCGACGGGGATGATGCC Pst I 049 ForwardAAAGAATTC-ATGCGGGCGCAGGCGTTTGATCAGCC Eco RI ReverseAAACTGCAG-AAGGCGTATCTGAAAAAATGGCAG Pst I 050 ForwardCGCGGATCCCATATG-GGCGCGGGCTGG BamHI- NdeI ReverseCCCGCTCGAG-AATCGGGCCATCTTCGA XhoI 052 ForwardAAAAAAGAATTC-ATGGCTTTGGTGGCGGAGGAAAC Eco RI ReverseAAAAAAGTCGAC-TCAGGCGGCGTTTTTCACCTTCCT Sal I 052a ForwardAAAAAAGAATTC-GTGGCGGAGGAAACGGAAATATCCGC Eco RI ReverseAAAAAACTGCAG-TTAGCTGTTTTTGGAAACGCCGTCCAACCC Pst I 073 ForwardCGCGGATCCCATATG-TGTATGCCATATAAGAT BamHI- NdeI ReverseCCCGCTCGAG-CACCGGATTGTCCGAC XhoI 075 ForwardCGCGGATCCCATATG-CCGTCTTACTTCATC BamHI- NdeI ReverseCCCGCTCGAG-ATCACCAATGCCGATTATTT XhoI 077a ForwardAAAAAAGAATTC-GGCGGCATTTTCATCGACACCTTCCT Eco RI ReverseAAAAAACTGCAG-TCAGACGAACATCTGCACAAACGCAAT Pst I 080 ForwardAAAGAATTC-GCGTCCGGGCTGGTTTGGTTTTACAATTC Eco RI ReverseAAACTGCAG-CTATTCTTCGGATTCTTTTTCGGG Pst I 081 ForwardAAAGAATTC-ATGAAACCACTGGACCTAAATTTCATCTG Eco RI ReverseAAACTGCAG-TCACTTATCCTCCAATGCCTC Pst I 082 ForwardAAAGAATTC-ATGTGGTTGTTGAAGTTGCCTGC Eco RI ReverseAAACTGCAG-TTACGCGGATTCGGCAGTTGG Pst I 084 ForwardAAAGAATTC-TATCACCCAGAATATGAATACGGCTACCG Eco RI ReverseAAACTGCAG-TTATACTTGGGCGCAACATGA Pst I 085 ForwardCGCGGATCCCATATG-GGTAAAGGGCAGGACT BamHI- NdeI ReverseCCCGCTCGAG-CAAAGCCTTAAACGCTTCG XhoI 086 ForwardAAAAAAGGTACC-TATTTGGCATCAAAAGAAGGCGG Kpn I ReverseAAACTGCAG-TTACTCCACCCGATAACCGCG Pst I 087 ForwardAAAGAATTC-ATGGGCGGTAAAACCTTTATGC Eco RI ReverseAAACTGCAG-TTACGCCGCACACGCAATCGC Pst I 087a ForwardAAAAAAGAATTC-AAGCTATTAGGCGTGCCGATTGTGATTCA Eco RI ReverseAAAAAACTGCAG-TTACGCCTGCAAGATGCCCAGCTTGCC Pst I 088 ForwardAAAAAAGAATTC-ATGTTTTTATGGCTCGCACATTTCAG Eco RI ReverseAAAAAACTGCAG-TCAGCGGATTTTGAGGGTACTCAAACC Pst I 089 ForwardCGCGGATCCCATATG-CCGCCCAAAATCAC BamHI- NdeI ReverseCCCGCTCGAG-TGCGCATACCAAAGCCA XhoI 090 ForwardCGCGGATCCCATATG-CGCATAGTCGAGCA BamHI- NdeI ReverseCCCGCTCGAG-AGCAAAACGGCGGTACG XhoI 091 ForwardAAAGAATTC-ATGGAAATACCCGTACCGCCGAGTCC Eco RI ReverseAAACTGCAG-TCAGCGCAGGGGGTAGCCCAAGCC Pst I 092 ForwardAAAGAATTC-ATGTTTTTTATTTCAATCCG Eco RI ReverseAAACTGCAG-TCAAATCTGTTTCGACAATGC Pst I 093 ForwardAAAGAATTC-ATGCAGAATTTTGGCAAAGTGGC Eco RI ReverseAAACTGCAG-CTATGGCTCGTCATACCGGGC Pst I 094 ForwardAAAGAATTC-ATGCCGTCACGGAAGCGCATCAACTC Eco RI ReverseAAACTGCAG-TTATCCCGGCCATACCGCCGAACA Pst I 095 ForwardAAAGAATTC-ATGTCCTTTCATTTGAACATGGACGG Eco RI ReverseAAACTGCAG-TCAACGCCGCAGGCACTAACGCCC Pst I 096 ForwardAAAGAATTC-ATGGCTCGTCATACCGGGCAGGG Eco RI ReverseAAACTGCAG-TCAAAGGAAAAGGCCGTCTGAAAAGCG Pst I 097 ForwardAAAGAATTC-ATGGACACTTCAAAACAAACACTGTTG Eco RI ReverseAAACTGCAG-TCAGCCCAAATACCAGAATTTCAG Pst I 098 ForwardAAAGAATTC-GATGAACGCAGCCCAGCATGGATACG Eco RI ReverseAAACTGCAG-TTACGACATTCTGATTTGGCA Pst I 102 ForwardAAAAAAGAATTC-GGCCTGATGATTTTGGAAGTCAACAC Eco RI ReverseAAAAAACTGCAG-TTATCCTTTAAATACGGGGACGAGTTC Pst I 105 ForwardCGCGGATCCCATATG-TCCGCAAACGAATACG BamHI- NdeI ReverseCCCGCTCGAG-GTGTTCTGCCAGTTTCAG XhoI 107 Forward AAAAAAGAATTC- Eco RICTGATGATTTTGGAAGTCAACACCCATTATCC ReverseAAAAAACTGCAG-TTATCCTTTAAATACGGGGACGAGTTC Pst I 107b ForwardAAAAAAGAATTC- Eco RI GATACCCAAGCCCCCGCCGGCACAAACTACTG ReverseAAAAAACTGCAG- Pst I TTACGCGTCGCCTTTAAAGTATTTGAGCAGGCTGGAGAC 108 ForwardAAAGAATTC-ATGTTGCCGGGCTTCAACCG Eco RI ReverseAAACTGCAG-TTAGCGGTACAGGTGTTTGAAGCA Pst I 108a ForwardAAAAAAGAATTC-GGTAACACATTCGGCAGCTTAGACGGTGG Eco RI ReverseAAACTGCAG-TTAGCGGTACAGGTGTTTGAAGCA Pst I 109 ForwardAAAGAATTC-ATGTATTATCGCCGGGTTATGGG Eco RI ReverseAAACTGCAG-CTAGCCCAAAGATTTGAAGTGTTC Pst I 111 ForwardCGCGGATCCCATATG-TGTTCGGAACAAACCGC BamHI- NdeI ReverseCCCGCTCGAG-GCGGAGCAGTTTTTCAAA XhoI 114 ForwardCGCGGATCCCATATG-GCTTCCATCACTTCGC BamHI- NdeI ReverseCCCGCTCGAG-CATCCGCGAAATCGTC XhoI 117 ForwardAAAAAAGGTACC-ATGGTCGAAGAACTGGAACTGCTG Kpn I ReverseAAACTGCAG-TTAAAGCCGGGTAACGCTCAATAC Pst I 118 ForwardAAAGTCGACATGTGTGAGTTCAAGGATATTATAAG Sal I ReverseAAAGCATGC-CTATTTTTTGTTGTAATAATCAAATC Sph I 121 ForwardCGCGGATCCCATATG-GAAACACAGCTTTACAT BamHI- NdeI ReverseCCCGCTCGAG-ATAATAATATCCCGCGCCC XhoI 122 ForwardCGCGGATCCCATATG-GTCATGATTAAAATCCGCA BamHI- NdeI ReverseCCCGCTCGAG-AATCTTGGTAGATTGGATTT XhoI 125 ForwardAAAGAATTC-ATGTCGGGCAATGCCTCCTCTCC Eco RI ReverseAAACTGCAG-TCACGCCGTTTCAAGACG Pst I 125a ForwardAAAAAAGAATTC-ACGGCAGGCAGCACCGCCGCACAGGTTTC Eco RI Reverse AAAAAACTGCAG-Pst I TTATTTTGCCACGTCGGTTTCTCCGGTGAACAACGC 126 ForwardCGCGGATCCCATATG-CCGTCTGAAACCC BamHI- NdeI ReverseCCCGCTCGAG-ATATTCCGCCGAATGCC XhoI 127 ForwardAAAGAATTC-ATGGAAATATGGAATATGTTGGACACTTG Eco RI ReverseAAACTGCAG-TTAAAGTGTTTCGGAGCCGGC Pst I 127a ForwardAAAAAAGAATTC-AAGGAACTGATTATGTGTCTGTCGGG Eco RI ReverseAAACTGCAG-TTAAAGTGTTTCGGAGCCGGC Pst I 128 ForwardCGCGGATCCCATATG-ACTGACAACGCACT BamHI- NdeI ReverseCCCGCTCGAG-GACCGCGTTGTCGAAA XhoI 130 ForwardCGCGGATCCCATATG-AAACAACTCCGCGA BamHI- NdeI ReverseCCCGCTCGAG-GAATTTTGCACCGGATTG XhoI 132 ForwardAAAGAATTC-ATGGAACCCTTCAAAACCTTAATTTG Eco RI ReverseAAAAAACTGCAG-TCACCATGTCGGCATTTGAAAAAC Pst I 134 ForwardCGCGGATCCCATATG-TCCCAAGAAATCCTC BamHI- NdeI ReverseCCCGCTCGAG-CAGTTTGACCGAATGTTC XhoI 135 ForwardCGCGGATCCCATATG-AAATACAAAAGAATCGTATT BamHI- NdeI ReverseCCCGCTCGAG-AAATTCGGTCAGAAGCAGG XhoI 137 ForwardAAAAAAGGTACC-ATGATTACCCATCCCCAATTCGATCC Kpn I ReverseAAAAAACTGCAG-TCAGTGCTGTTTTTTCATGCCGAA Pst I 137a ForwardAAAAAAGAATTC-GGCCGCAAACACGGCATCGGCTTCCT Eco RI ReverseAAAAAACTGCAG-TTAAGCGGGATGACGCGGCAGCATACC Pst I 138 ForwardAAAAAAGAATTC-AACTCAGGCGAAGGAGTGCTTGTGGC Eco RI ReverseAAAAAATCTAGA-TCAGTTTAGGGATAGCAGGCGTAC Xba I 141 ForwardAAAGAATTC-ATGAGCTTCAAAACCGATGCCGAAATCGC Eco RI ReverseAAACTGCAG-TCAGAACAAGCCGTGAATCACGCC Pst I 142 ForwardCGCGGATCCCATATG-CGTGCCGATTTCATG BamHI- NdeI ReverseCCCGCTCGAG-AAACTGCTGCACATGGG XhoI 143 Forward AAAAAAGAATTC- Eco RIATGCTCAGTTTCGGCTTTCTCGGCGTTCAGAC ReverseAAAAAACTGCAG-TCAAACCCCGCCGTGTGTTTCTTTAAT Pst I 144 ForwardAAAAAAGAATTC-GGTCTGATCGACGGGCGTGCCGTAAC Eco RI ReverseAAAAAATCTAGA-TCGGCATCGGCCGGCATATGTCCG Xba I 146 Forward AAAAAAGAATTC-Eco RI CGCCAAGTCGTCATTGACCACGACAAAGTC ReverseAAAAAACTGCAG-TTAGGCATCGGCAAATAGGAAACTGGG Pst I 147 ForwardAAAAAAGAATTC-ACTGAGCAATCGGTGGATTTGGAAAC Eco RI ReverseAAAAAATCTAGA-TTAGGTAAAGCTGCGGCCCATTTGCGG Xba I 148 Forward AAAAAAGAATTC-Eco RI ATGGCGTTAAAAACATCAAACTTGGAACACGC ReverseAAAAAATCTAGA-TCAGCCCTTCATACAGCCTTCGTTTTG Xba I 149 ForwardCGCGGATCCCATATG-CTGCTTGACAACAAAGT BamHI- NdeI ReverseCCCGCTCGAG-AAACTTCACGTTCACGCC XhoI 150 ForwardCGCGGATCCCATATG-CAGAACACAAATCCG BamHI- NdeI ReverseCCCGCTCGAG-ATAAACATCACGCTGATAGC XhoI 151 Forward AAAAAAGAATTC- Eco RIATGAAACAAATCCGCAACATCGCCATCATCGC ReverseAAAAAACTGCAG-TCAATCCAGCTTTTTAAAGTGGCGGCG Pst I 152 Forward AAAAAAGAATTC-Eco RI ATGAAAAACAAAACCAAAGTCTGGGACCTCCC ReverseAAAAAACTGCAG-TCAGGACAGGAGCAGGATGGCGGC Pst I 153 ForwardAAAAAAGAATTC-ATGGCGTTTGCTTACGGTATGAC Eco RI ReverseAAAAAACTGCAG-TCAGTCATGTTTTTCCGTTTCATT Pst I 153a ForwardAAAAAAGAATTC-CGGACTTCGGTATCGGTTCCCCAGCATTG Eco RI Reverse AAAAAACTGCAG-Pst I TTACGCCGACGAAATACTCAGACTTTTCGG 154 ForwardCGCGGATCCCATATG-ACTGACAACAGCCC BamHI- NdeI ReverseCCCGCTCGAG-TCGGCTTCCTTTCGGG XhoI 155 ForwardAAAAAAGAATTC-ATGAAAATCGGTATCCCACGCGAGTC Eco RI ReverseAAAAAACTGCAG-TTACCCTTTCTTAAACATATTCAGCAT Pst I 156 ForwardAAAAAAGAATTC-GCACAGCAAAACGGTTTTGAAGC Eco RI ReverseAAAAAACTGCAG-TCAAGCAGCCGCGACAAACAGCCC Pst I 157 ForwardCGCGGATCCCATATG-AGGAACGAGGAAAAAC BamHI- NdeI ReverseCCCGCTCGAG-AAAACACAATATCCCCGC XhoI 158 ForwardAAAAAAGAATTC-GCGGAGCAGTTGGCGATGGCAAATTCTGC Eco RI ReverseAAAAAATCTAGA-TTATCCACAGAGATTGTTTCCCAGTTC Xba I 160 ForwardCGCGGATCCCATATG-GACATTCTGGACAAAC BamHI- NdeI ReverseCCCGCTCGAG-TTTTTGCCCGCCTTCTTT XhoI 163 ForwardAAAAAAGGTACC-ACCGTGCCGGATCAGGTGCAGATGTG Kpn I ReverseAAAAAATCTAGA-TTACTCTGCCAATTCCACCTGCTCGTG Xba I 163a ForwardAAAAAAGAATTC-CGGCTGGTGCAGATAATGAGCCAGAC Eco RI ReverseAAAAAATCTAGA-TTACTCTGCCAATTCCACCTGCTCGTG Xba I 164 ForwardCGCGGATCCCATATG-AACCGGACTTATGCC BamHI- NdeI ReverseCCCGCTCGAG-TTTGTTTCCGTCAAACTGC XhoI 165 ForwardCGCGGATCCGCTAGC-GCTGAAGCGACAGACG BamHI- NheI ReverseCCCGCTCGAG-AATATCCAATACTTTCGCG XhoI 206 ForwardCGCGGATCCCATATG-AAACACCGCCAACCGA BamHI- NdeI ReverseCCCGCTCGAG-TTCTGTAAAAAAAGTATGTGC XhoI 209 ForwardCGCGGATCCCATATG-CTGCGGCATTTAGGA BamHI- NdeI ReverseCCCGCTCGAG-TACCCCTGAAGGCAAC XhoI 211 ForwardAAAAAAGAATTC-ATGTTGCGGGTTGCTGCTGC Eco RI ReverseAAAAAACTGCAG-CTATCCTGCGGATTGGCATTGAAA Pst I 212 ForwardCGCGGATCCCATATG-GACAATCTCGTATGG BamHI- NdeI ReverseCCCGCTCGAG-AGGGGTTAGATCCTTCC XhoI 215 ForwardCGCGGATCCCATATG-GCATGGTTGGGTCGT BamHI- NdeI ReverseCCCGCTCGAG-CATATCTTTTGTATCATAAATC XhoI 216 ForwardCGCGGATCCCATATG-GCAATGGCAGAAAACG BamHI- NdeI ReverseCCCGCTCGAG-TACAATCCGTGCCGCC XhoI 217 ForwardCGCGGATCCCATATG-GCGGATGACGGTGTG BamHI- NdeI ReverseCCCGCTCGAG-ACCCCGAATATCGAATCC XhoI 218 ForwardCGCGGATCCCATATG-GTCGCGGTCGATC BamHI- NdeI ReverseCCCGCTCGAG-TAACTCATAGAATCCTGC XhoI 219 ForwardCGCGGATCCGCTAGC-ACGGCAAGGTTAAG BamHI- NheI ReverseCCCGCTCGAG-TTTAAACCATCTCCTCAAAAC XhoI 223 ForwardCGCGGATCCCATATG-GAATTCAGGCACCAAGTA BamHI- NdeI ReverseCCCGCTCGAG-GGCTTCCCGCGTGTC XhoI 225 ForwardCGCGGATCCCATATG-GACGAGTTGACCAACC BamHI- NdeI ReverseCCCGCTCGAG-GTTCAGAAAGCGGGAC XhoI 226 ForwardAAAGAATTC-CTTGCGATTATCGTGCGCACGCG Eco RI ReverseAAACTGCAG-TCAAAATCCCAAAACGGGGAT Pst I 228 ForwardCGCGGATCCCATATG-TCGCAAGAAGCCAAACAG BamHI- NdeI ReverseCCCGCTCGAG-TTTGGCGGCATCTTTCAT XhoI 229 ForwardCGCGGATCCCATATG-CAAGAGGTTTTGCCC BamHI- NdeI ReverseCCCGCTCGAG-ACACAATATAGCGGATGAAC XhoI 230 ForwardCGCGGATCCCATATG-CATCCGGGTGCCGAC BamHI- NdeI ReverseCCCGCTCGAG-AAGTTTGGCGGCTTCGG XhoI 232 ForwardAAAAAAGAATTC-ATGTACGCTAAAAAAGGCGGTTTGGG Eco RI ReverseAAAAAACTGCAG-TCAAGGTTTTTTCCTGATTGCCGCCGC Pst I 232a ForwardAAAAAAGAATTC-GCCAAGGCTGCCGATACACAAATTGA Eco RI ReverseAAAAAACTGCAG-TTAAACATTGTCGTTGCCGCCCAGATG Pst I 233 ForwardCGCGGATCCCATATG-GCGGACAAACCCAAG BamHI- NdeI ReverseCCCGCTCGAG-GACGGCATTGAGCAG XhoI 234 ForwardCGCGGATCCCATATG-GCCGTTTCACTGACCG BamHI- NdeI ReverseGCCCAAGCTT-ACGGTTGGATTGCCATG Hind III 235 ForwardCGCGGATCCCATATG-GCCTGCCAAGTTCAAA BamHI- NdeI ReverseCCCGCTCGAG-TTTGGGCTGCTCTTC XhoI 236 ForwardCGCGGATCCCATATG-GCGCGTTTCGCCTT BamHI- NdeI ReverseCCCGCTCGAG-ATGGGTCGCGCGCCGT XhoI 238 ForwardCGCGGATCCGCTAGC-AACGGTTTGGATGCCCG BamHI- NheI ReverseCCCGCTCGAG-TTTGTCTAAGTTCCTGATATG XhoI 239 ForwardCCGGAATTCTACATATG-CTCCACCATAAAGGTATTG EcoRI- NdeI ReverseCCCGCTCGAG-TGGTGAAGAGCGGTTTAG XhoI 240 ForwardCGCGGATCCCATATG-GACGTTGGACGATTTC BamHI- NdeI ReverseCCCGCTCGAG-AAACGCCATTACCCGATG XhoI 241 ForwardCCGGAATTCTACATATG-CCAACACGTCCAACT EcoRI- NdeI ReverseCCCGCTCGAG-GAATGCGCCTGTAATTAATC XhoI 242 ForwardCGCGGATCCCATATG-ATCGGCAAACTTGTTG BamHI- NdeI ReverseGCCCAAGCTT-ACCGATACGGTCGCAG HindIII 243 ForwardCGCGGATCCCATATG-ACGATTTTTTCGATGCTGC BamHI- NdeI ReverseCCCGCTCGAG-CGACTTGGTTACCGCG XhoI 244 ForwardCGCGGATCCCATATG-CCGTCTGAAGCCC BamHI- NdeI ReverseCCCGCTCGAG-TTTTTTCGGTAGGGGATTT XhoI 246 ForwardCGCGGATCCCATATG-GACATCGGCAGTGC BamHI- NdeI ReverseCCCGCTCGAG-CCCGCGCTGCTGGAG XhoI 247 ForwardCGCGGATCCCATATG-GTCGGATCGAGTTAC BamHI- NdeI ReverseCCCGCTCGAG-AAGTGTTCTGTTTGCGCA XhoI 248 ForwardCGCGGATCCCATATG-CGCAAACAGAACACT BamHI- NdeI ReverseCCCGCTCGAG-CTCATCATTATTGCTAACA XhoI 249 ForwardCGCGGATCCCATATG-AAGAATAATGATTGCTTC BamHI- NdeI ReverseCCCGCTCGAG-TTCCCGACCTCCGAC XhoI 251 ForwardCGCGGATCCCATATG-CGTGCTGCGGTAGT BamHI- NdeI ReverseCCCGCTCGAG-TACGAAAGCCGGTCGTG XhoI 253 ForwardAAAAAAGAATTC-ATGATTGACAGGAACCGTATGCTGCG Eco RI ReverseAAAAAACTGCAG-TTATTGGTCTTTCAAACGCCCTTCCTG Pst I 253a ForwardAAAAAAGAATTC-AAAATCCTTTTGAAAACAAGCGAAAACGG Eco RI ReverseAAAAAACTGCAG-TTATTGGTCTTTCAAACGCCCTTCCTG Pst I 254 ForwardAAAAAAGAATTC-ATGTATACAGGCGAACGCTTCAATAC Eco RI ReverseAAAAAATCTAGA-TCAGATTACGTAACCGTACACGCTGAC Xba I 255 ForwardCGCGGATCCCATATG-GCCGCGTTGCGTTAC BamHI- NdeI ReverseCCCGCTCGAG-ATCCGCAATACCGACCAG XhoI 256 ForwardCGCGGATCCGCTAGC-TTTTAACACCGCCGGAC BamHI- NheI ReverseCCCGCTCGAG-ACGCCTGTTTGTGCGG XhoI 257 ForwardCGCGGATCCCATATG-GCGGTTTCTTTCCTG BamHI- NdeI ReverseCCCGCTCGAG-GCGCGTGAATATCGCG XhoI 258 ForwardAAAAAAGAATTC-GATTATTTCTGGTGGATTGTTGCGTTCAG Eco RI ReverseAAAAAACTGCAG-CTACGCATAAGTTTTTACCGTTTTTGG Pst I 258a ForwardAAAAAAGAATTC-GCGAAGGCGGTGGCGCAAGGCGA Eco RI ReverseAAAAAACTGCAG-CTACGCATAAGTTTTTACCGTTTTTGG Pst I 259 ForwardCGCGGATCCCATATG-GAAGAGCTGCCTCCG BamHI- NdeI ReverseCCCGCTCGAG-GGCTTTTCCGGCGTTT XhoI 260 ForwardCGCGGATCCCATATG-GGTGCGGGTATGGT BamHI- NdeI ReverseCCCGCTCGAG-AACAGGGCGACACCCT XhoI 261 ForwardAAAAAAGAATTC-CAAGATACAGCTCGGGCATTCGC Eco RI ReverseAAAAAACTGCAG-TCAAACCAACAAGCCTTGGTCACT Pst I 263 ForwardCGCGGATCCCATATG-GCACGTTTAACCGTA BamHI- NdeI ReverseCCCGCTCGAG-GGCGTAAGCCTGCAATT XhoI 264 ForwardAAAAAAGGTACC-GCCGACGCAGTGGTCAAGGCAGAA Kpn I ReverseAAACTGCAG-TCAGCCGGCGGTCAATACCGCCCG Pst I 265 ForwardAAAAAAGAATTC-GCGGAGGTCAAGAGAAGGTGTTTG Eco RI ReverseAAAAAACTGCAG-TTACGAATACGTCGTCAAAATGGG Pst I 266 ForwardAAAGAATTC-CTCATCTTTGCCAACGCCCCCTTC Eco RI ReverseAAACTGCAG-CTATTCCCTGTTGCGCGTGTGCCA Pst I 267 ForwardAAAGAATTC-TTCTTCCGATTCGATGTTAATCG Eco RI ReverseAAACTGCAG-TTAGTAAAAACCTTTCTGCTTGGC Pst I 269 ForwardAAAGAATTC-TGCAAACCTTGCGCCACGTGCCC Eco RI ReverseAAACTGCAG-TTACGAAGACCGCAACGAAAGGCAGAG Pst I 269a ForwardAAAAAAGAATTC-GACTTTATCCAAAACACGGCTTCGCC Eco RI ReverseAAACTGCAG-TTACGAAGACCGCAACGAAAGGCAGAG Pst I 270 ForwardAAAGAATTC-GCCGTCAAGCTCGTTTTGTTGCAATG Eco RI ReverseAAACTGCAG-TTATTCGGCGGTAAATGCCGTCTG Pst I 271 ForwardCGCGGATCCCATATG-CCTGTGTGCAGCTCGAC BamHI- NdeI ReverseCCCGCTCGAG-TCCCAGCCCCGTGGAG XhoI 272 ForwardAAAGAATTC-ATGACCGCAAAGGAAGAACTGTTCGC Eco RI ReverseAAACTGCAG-TCAGAGCAGTTCCAAATCGGGGCT Pst I 273 ForwardAAAGAATTC-ATGAGTCTTCAGGCGGTATTTATATACCC Eco RI ReverseAAACTGCAG-TTACGCGTAAGAAAAAACTGC Pst I 274 ForwardCGCGGATCCCATATG-ACAGATTTGGTTACGGAC BamHI- NdeI ReverseCCCGCTCGAG-TTTGCTTTCAGTATTATTGAA XhoI 276 Forward AAAAAAGAATTC- Eco RIATGATTTTGCCGTCGTCCATCACGATGATGCG ReverseAAAAAACTGCAG-CTACACCACCATCGGCGAATTTATGGC Pst I 277 ForwardAAAAAAGAATTC-ATGCCCCGCTTTGAGGACAAGCTCGTAGG Eco RI ReverseAAAAAACTGCAG-TCATAAGCCATGCTTACCTTCCAACAA Pst I 277a ForwardAAAAAAGAATTC-GGGGCGGCGGCTGGGTTGGACGTAGG Eco RI ReverseAAAAAACTGCAG-TCATAAGCCATGCTTACCTTCCAACAA Pst I 278 ForwardAAAAAAGGTACC-GTCAAAGTTGTATTAATCGGGCCTTTGCC Kpn I ReverseAAAAAACTGCAG-TCATTCAACCATATCAAATCTGCC Pst I 278a ForwardAAAAAAGAATTC-AAAACTCTCCTAATTCGTCATAGTCG Eco RI ReverseAAAAAACTGCAG-TCATTCAACCATATCAAATCTGCC Pst I 279 ForwardCGCGGATCCCATATG-TTGCCTGCAATCACGATT BamHI- NdeI ReverseCCCGCTCGAG-TTTAGAAGCGGGCGGCAA XhoI 280 ForwardAAAAAAGGTACC-GCCCCCCTGCCGGTTGTAACCAG Kpn I ReverseAAAAAACTGCAG-TTATTGCTTCATCGCGTTGGTCAAGGC Pst I 281 ForwardAAAAAAGAATTC-GCACCCGTCGGCGTATTCCTCGTCATGCG Eco RI ReverseAAAAAATCTAGA-GGTCAGAATGCCGCCTTCTTTGCCGAG Xba I 281a ForwardAAAAAAGAATTC-TCCTACCACATCGAAATTCCTTCCGG Eco RI ReverseAAAAAATCTAGA-GGTCAGAATGCCGCCTTCTTTGCCGAG Xba I 282 ForwardAAAAAAGAATTC-CTTTACCTTGACCTGACCAACGGGCACAG Eco RI ReverseAAAAAACTGCAG-TCAACCTGCCAGTTGCGGGAATATCGT Pst I 283 ForwardCGCGGATCCCATATG-GCCGTCTTTACTTGGAAG BamHI- NdeI ReverseCCCGCTCGAG-ACGGCAGTATTTGTTTACG XhoI 284 ForwardCGCGGATCCCATATG-TTTGCCTGCAAAAGAATCG BamHI- NdeI ReverseCCCGCTCGAG-CCGACTTTGCAAAAACTG XhoI 286 ForwardCGCGGATCCCATATG-GCCGACCTTTCCGAAAA BamHI- NdeI ReverseCCCGCTCGAG-GAAGCGCGTTCCCAAG XhoI 287 ForwardCCGGAATTCTAGCTAGC-CTTTCAGCCTGCGGG EcoRI- NheI ReverseCCCGCTCGAG-ATCCTGCTCTTTTTTGCC XhoI 288 ForwardCGCGGATCCCATATG-CACACCGGACAGG BamHI- NdeI ReverseCCCGCTCGAG-CGTATCAAAGACTTGCGT XhoI 290 ForwardCGCGGATCCCATATG-GCGGTTTGGGGCGGA BamHI- NdeI ReverseCCCGCTCGAG-TCGGCGCGGCGGGC XhoI 292 ForwardCGCGGATCCCATATG-TGCGGGCAAACGCCC BamHI- NdeI ReverseCCCGCTCGAG-TTGATTTTTGCGGATGATTT XhoI 294 ForwardAAAAAAGAATTC-GTCTGGTCGATTCGGGTTGTCAGAAC Eco RI ReverseAAAAAACTGCAG-TTACCAGCTGATATAAAACATCGCTTT Pst I 295 ForwardCGCGGATCCCATATG-AACCGGCCGGCCTCC BamHI- NdeI ReverseCCCGCTCGAG-CGATATTTGATTCCGTTGC XhoI 297 ForwardAAAAAAGAATTC-GCATACATTGCTTCGACAGAGAG Eco RI ReverseAAAAAACTGCAG-TCAATCCGATTGCGACACGGT Pst I 298 ForwardAAAAAAGAATTC-CTGATTGCCGTGTGGTTCAGCCAAAACCC Eco RI ReverseAAAAAACTGCAG-TCATGGCTGTGTACTTGATGGTTGCGT Pst I 299 ForwardCGCGGATCCGCTAGC-CTACCTGTCGCCTCCG BamHI- NheI ReverseCCCGCTCGAG-TTGCCTGATTGCAGCGG XhoI 302 ForwardAAAAAAGAATTC-ATGAGTCAAACCGATACGCAACG Eco RI ReverseAAAAAACTGCAG-TTAAGGTGCGGGATAGAATGTGGGCGC Pst I 305 ForwardAAAAAAGGTACC-GAATTTTTACCGATTTCCAGCACCGGA Kpn I ReverseAAAAAACTGCAG-TCATTCCCAACTTATCCAGCCTGACAG Pst I 305a ForwardAAAAAAGGTACC-TCCCGTTCGGGCAGTACGATTATGGG Kpn I ReverseAAAAAACTGCAG-TTACAAACCGACATCATGCAGGGTGAA Pst I 306 ForwardCGCGGATCCCATATG-TTTATGAACAAATTTTCCC BamHI- NdeI ReverseCCCGCTCGAG-CCGCATCGGCAGAC XhoI 308 ForwardCGCGGATCCCATATG-TTAAATCGGGTATTTTATC BamHI- NdeI ReverseCCCGCTCGAG-ATCCGCCATTCCCTGC XhoI 311 ForwardAAAAAAGGTACC-ATGTTCAGTTTTGGCTGGGTGTTT Kpn I ReverseAAACTGCAG-ATGTTCATATTCCCTGCCTTCGGC Pst I 312 ForwardAAAAAAGGTACC-ATGAGTATCCCATCCGGCGAAATT Kpn I ReverseAAACTGCAG-TCAGTTTTTCATCGATTGAACCGG Pst I 313 ForwardAAAAAAGAATTC-ATGGACGACCCGCGCACCTACGGATC Eco RI ReverseAAAAAACTGCAG-TCAGCGGCTGCCGCCGATTTTGCT Pst I 401 ForwardCGCGGATCCCATATG-AAGGCGGCAACACAGC BamHI- NdeI ReverseCCCGCTCGAG-CCTTACGTTTTTCAAAGCC XhoI 402 ForwardAAAAAAGAATTC-GTGCCTCAGGCATTTTCATTTACCCTTGC Eco RI ReverseAAAAAATCTAGA-TTAAATCCCTCTGCCGTATTTGTATTC Xba I 402a ForwardAAAAAAGAATTC-AGGCTGATTGAAAACAAACACGG Eco RI ReverseAAAAAATCTAGA-TTAAATCCCTCTGCCGTATTTGTATTC Xba I 406 ForwardCGCGGATCCCATATG-TGCGGGACACTGACAG BamHI- NdeI ReverseCCCGCTCGAG-AGGTTGTCCTTGTCTATG XhoI 501 ForwardCGCGGATCCCATATG-GCAGGCGGAGATGGC BamHI- NdeI ReverseCCCGCTCGAG-GGTGTGATGTTCACCC XhoI 502 ForwardCGCGGATCCCATATG-GTAGACGCGCTTAAGCA BamHI- NdeI ReverseCCCGCTCGAG-AGCTGCATGGCGGCG XhoI 503 ForwardCGCGGATCCCATATG-TGTTCGGGGAAAGGCG BamHI- NdeI ReverseCCCGCTCGAG-CCGCGCATTCCTCGCA XhoI 504 ForwardCGCGGATCCCATATG-AGCGATATTGAAGTGACG BamHI- NdeI ReverseGCCCAAGCTT-TGATTCAAGTCCTTGCCG HindIII 505 ForwardCGCGGATCCCATATG-TTTCGTTTACAATTCAGG BamHI- NdeI ReverseCCCGCTCGAG-CGGCGTTTTATAGCGG XhoI 510 ForwardCGCGGATCCCATATG-CCTTCGCGGACAC BamHI- NdeI ReverseCCCGCTCGAG-GCGCACTGGCAGCG XhoI 512 ForwardCGCGGATCCCATATG-GGACATGAAGTAACGGT BamHI- NdeI ReverseCCCGCTCGAG-AGGAATAGCCTTTGACG XhoI 515 ForwardCGCGGATCCCATATG-GAGGAAATAGCCTTCGA BamHI- NdeI ReverseCCCGCTCGAG-AAATGCCGCAAAGCATC XhoI 516 ForwardCGCGGATCCCATATG-TGTACGTTGATGTTGTGG BamHI- NdeI ReverseCCCGCTCGAG-TTTGCGGGCGGCATC XhoI 517 ForwardCGCGGATCCCATATG-GGTAAAGGTGTGGAAATA BamHI- NdeI ReverseCCCGCTCGAG-GTGCGCCCAGCCGT XhoI 518 ForwardAAAGAATTC-GCTTTTTTACTGCTCCGACCGGAAGG Eco RI ReverseAAACTGCAG-TCAAATTTCAGACTCTGCCAC Pst I 519 ForwardCGCGGATCCCATATG-TTCAAATCCTTTGTCGTCA BamHI- NdeI ReverseCCCGCTCGAG-TTTGGCGGTTTTGCTGC XhoI 520 ForwardCGCGGATCCCATATG-CCTGCGCTTCTTTCA BamHI- NdeI ReverseCCCGCTCGAG-ATATTTACATTTCAGTCGGC XhoI 521 ForwardCGCGGATCCCATATG-GCCAAAATCTATACCTGC BamHI- NdeI ReverseCCCGCTCGAG-CATACGCCCCAGTTCC XhoI 522 ForwardCGCGGATCCCATATG-ACTGAGCCGAAACAC BamHI- NdeI ReverseGCCCAAGCTT-TTCTGATTTCAAATCGGCA HindIII 523 ForwardCGCGGATCCCATATG-GCTCTGCTTTCCGCG BamHI- NdeI ReverseCCCGCTCGAG-AGGGTGTGTGATAATAAGAAG XhoI 525 ForwardCGCGGATCCCATATG-GCCGAAATGGTTCAAATC BamHI- NdeI ReverseCCCGCTCGAG-GCCCGTGCATATCATAAA XhoI 527 ForwardAAAGAATTC-TTCCCTCAATGTTGCCGTTTTCG Eco RI ReverseAAACTGCAG-TTATGCTAAACTCGAAACAAATTC Pst I 529 ForwardCGCGGATCCGCTAGC-TGCTCCGGCAGCAAAAC BamHI- NheI ReverseGCCCAAGCTT-ACGCAGTTCGGAATGGAG HindIII 530 ForwardCGCGGATCCCATATG-AGTGCGAGCGCGG BamHI- NdeI ReverseCCCGCTCGAG-ACGACCGACTGATTCCG XhoI 531 ForwardAAAAAAGAATTC-TATGCCGCCGCCTACCAAATCTACGG Eco RI ReverseAAAAAACTGCAG-TTAAAACAGCGCCGTGCCGACGACAAG Pst I 532 ForwardAAAAAAGAATTC-ATGAGCGGTCAGTTGGGCAAAGGTGC Eco RI ReverseAAAAAACTGCAG-TCAGTGTTCCAAGTGGTCGGTATCAAA Pst I 532a ForwardAAAAAAGAATTC-TTGGGTGTCGCGTTTGAGCCGGAAGT Eco RI ReverseAAAAAACTGCAG-TCAGTGTTCCAAGTGGTCGGTATCAAA Pst I 535 ForwardAAAGAATTC-ATGCCCTTTCCCGTTTTCAGAC Eco RI ReverseAAACTGCAG-TCAGACGACCCCGCCTTCCCC Pst I 537 ForwardCGCGGATCCCATATG-CATACCCAAAACCAATCC BamHI- NdeI ReverseCCCGCTCGAG-ATCCTGCAAATAAAGGGTT XhoI 538 ForwardCGCGGATCCCATATG-GTCGAGCTGGTCAAAGC BamHI- NdeI ReverseCCCGCTCGAG-TGGCATTTCGGTTTCGTC XhoI 539 ForwardCGCGGATCCGCTAGC-GAGGATTTGCAGGAAA BamHI- NheI ReverseCCCGCTCGAG-TACCAATGTCGGCAAATC XhoI 542 ForwardAAAGAATTC-ATGCCGTCTGAAACCGTGTC Eco RI ReverseAAACTGCAG-TTACCGCGAACCGGTCAGGAT Pst I 543 ForwardAAAAAAGAATTC-GCCTTCGATGGCGACGTTGTAGGTAC Eco RI Reverse AAAAAATCTAGA- XbaI TTAATGAAGAAGAACATATTGGAATTTTGG 543a ForwardAAAAAAGAATTC-GGCAAAACTCGTCATGAATTTGC Eco RI Reverse AAAAAATCTAGA- Xba ITTAATGAAGAAGAACATATTGGAATTTTGG 544 ForwardAAAGAATTC-GCGCCCGCCTTCTCCCTGCCCGACCTGCACGG Eco RI ReverseAAACTGCAG-CTATTGCGCCACGCGCGTATCGAT Pst I 544a Forward AAAAAAGAATTC- EcoRI GCAAATGACTATAAAAACAAAAACTTCCAAGTACTTGC ReverseAAACTGCAG-CTATTGCGCCACGCGCGTATCGAT Pst I 547 ForwardAAAGAATTC-ATGTTCGTAGATAACGGATTTAATAAAAC Eco RI ReverseAAACTGCAG-TTAACAACAAAAAACAAACCGCTT Pst I 548 ForwardAAAGAATTC-GCCTGCAAACCTCAAGACAACAGTGCGGC Eco RI ReverseAAACTGCAG-TCAGAGCAGGGTCCTTACATCGGC Pst I 550 Forward AAAAAAGTCGAC- Sal IATGATAACGGACAGGTTTCATCTCTTTCATTTTCC ReverseAAACTGCAG-TTACGCAAACGCTGCAAAATCCCC Pst I 550a ForwardAAAAAAGAATTC-GTAAATCACGCCTTTGGAGTCGCAAACGG Eco RI ReverseAAACTGCAG-TTACGCAAACGCTGCAAAATCCCC Pst I 552 ForwardAAAAAAGAATTC-TTGGCGCGTTGGCTGGATAC Eco RI ReverseAAACTGCAG-TTATTTCTGATGCCTTTTCCCAAC Pst I 554 ForwardCGCGGATCCCATATG-TCGCCCGCGCCCAAC BamHI- NdeI ReverseCCCGCTCGAG-CTGCCCTGTCAGACAC XhoI 556 ForwardAAAGAATTC-GCGGGCGGTTTTGTTTGGACATCCCG Eco RI ReverseAAACTGCAG-TTAACGGTGCGGACGTTTCTGACC Pst I 557 ForwardCGCGGATCCCATATG-TGCGGTTTCCACCTGAA BamHI- NdeI ReverseCCCGCTCGAG-TTCCGCCTTCAGAAAGG XhoI 558 ForwardAAAGAATTC-GAGCTTTATATGTTTCAACAGGGGACGGC Eco RI ReverseAAACTGCAG-CTAAACAATGCCGTCTGAAAGTGGAGA Pst I 558a ForwardAAAAAAGAATTC-ATTAGATTCTATCGCCATAAACAGACGGG Eco RI ReverseAAAAAACTGCAG-CTAAACAATGCCGTCTGAAAGTGGAGA Pst I 560 Forward AAAAAAGAATTC-Eco RI TCGCCTTTCCGGGACGGGGCGCACAAGATGGC ReverseAAAAAACTGCAG-TCATGCGGTTTCAGACGGCATTTTGGC Pst I 561 ForwardCCGGAATTCTACATATG-ATACTGCCAGCCCGT EcoRI- NdeI ReverseCCCGCTCGAG-TTTCAAGCTTTCTTCAGATG XhoI 562 ForwardCGCGGATCCCATATG-GCAAGCCCGTCGAG BamHI- NdeI ReverseCCCGCTCGAG-AGACCAACTCCAACTCGT XhoI 565 ForwardCGCGGATCCCATATG-AAGTCGAGCGCGAAATAC BamHI- NdeI ReverseCCCGCTCGAG-GGCATTGATCGGCGGC XhoI 566 ForwardCGCGGATCCCATATG-GTCGGTGGCGAAGAGG BamHI- NdeI ReverseCCCGCTCGAG-CGCATGGGCGAAGTCA XhoI 567 ForwardCCGGAATTCTACATATG-AGTGCGAACATCCTTG EcoRI- NdeI ReverseCCCGCTCGAG-TTTCCCCGACACCCTCG XhoI 568 ForwardCGCGGATCCCATATG-CTCAGGGTCAGACC BamHI- NdeI ReverseCCCGCTCGAG-CGGCGCGGCGTTCAG XhoI 569 ForwardAAAAAAGAATTC-CTGATTGCCTTGTGGGAATATGCCCG Eco RI ReverseAAAAAACTGCAG-TTATGCATAGACGCTGATAACGGCAAT Pst I 570 ForwardCGCGGATCCCATATG-GACACCTTCCAAAAAATCG BamHI- NdeI ReverseCCCGCTCGAG-GCGGGCGTTCATTTCTTT XhoI 571 Forward AAAAAAGAATTC- Eco RIATGGGTATTGCCGGCGCCGTAAATGTTTTGAACCC ReverseAAAAAACTGCAG-TTATGGCCGACGCGCGGCTACCTGACG Pst I 572 ForwardCGCGGATCCCATATG-GCGCAAAAAGGCAAAACC BamHI- NdeI ReverseCCCGCTCGAG-GCGCAGTGTGCCGATA XhoI 573 ForwardCGCGGATCCCATATG-CCCTGTTTGTGCCG BamHI- NdeI ReverseCCCGCTCGAG-GACGGTGTCATTTCGCC XhoI 574 ForwardCGCGGATCCCATATG-TGGTTTGCCGCCCGC BamHI- NdeI ReverseCCCGCTCGAG-AACTTCGATTTTATTCGGG XhoI 575 ForwardCGCGGATCCCATATG-GTTTCGGGCGAGG BamHI- NdeI ReverseCCCGCTCGAG-CATTCCGAATCTGAACAG XhoI 576 ForwardCGCGGATCCCATATG-GCCGCCCCCGCATCT BamHI- NdeI ReverseCCCGCTCGAG-ATTTACTTTTTTGATGTCGAC XhoI 577 ForwardCGCGGATCCCATATG-GAAAGGAACGGTGTATTT BamHI- NdeI ReverseCCCGCTCGAG-AGGCTGTTTGGTAGATTCG XhoI 578 ForwardCGCGGATCCCATATG-AGAAGGTTCGTACAG BamHI- NdeI ReverseCCCGCTCGAG-GCCAACGCCTCCACG XhoI 579 ForwardCGCGGATCCCATATG-AGATTGGGCGTTTCCAC BamHI- NdeI ReverseCCCGCTCGAG-AGAATTGATGATGTGTATGT XhoI 580 ForwardCGCGGATCCCATATG-AGGCAGACTTCGCCGA BamHI- NdeI ReverseCCCGCTCGAG-CACTTCCCCCGAAGTG XhoI 581 ForwardCGCGGATCCCATATG-CACTTCGCCCAGC BamHI- NdeI ReverseCCCGCTCGAG-CGCCGTTTGGCTTTGG XhoI 582 ForwardAAAAAAGAATTC-TTTGGAGAGACCGCGCTGCAATGCGC Eco RI ReverseAAAAAATCTAGA-TCAGATGCCGTCCCAGTCGTTGAA Xba I 583 ForwardAAAAAAGAATTC-ACTGCCGGCAATCGACTGCATAATCG Eco RI ReverseAAAAAACTGCAG-TTAACGGAGGTCAATATGATGAAATTG Pst I 584 Forward AAAAAAGAATTC-Eco RI GCGGCTGAAGCATTGAATTACAATATTGTC ReverseAAAAAACTGCAG-TCAGAACTGAACCGTCCCATTGACGCT Pst I 585 ForwardAAAAAAGGTACC-TCTTTCTGGCTGGTGCAGAACACCCTTGC Eco RI ReverseAAAAAACTGCAG-TCAGTTCGCACTTTTTTCTGTTTTGGA Pst I 586 ForwardCGCGGATCCCATATG-GCAGCCCATCTCG BamHI- NdeI ReverseCCCGCTCGAG-TTTCAGCGAATCAAGTTTC XhoI 587 ForwardCGCGGATCCCATATG-GACCTGCCCTTGACGA BamHI- NdeI ReverseCCCGCTCGAG-AAATGTATGCTGTACGCC XhoI 588 ForwardAAAAAAGAATTC-GCCGTCCTGACTTCCTATCAAGAACCAGG Eco RI ReverseAAAAAACTGCAG-TTATTTGTTTTTGGGCAGTTTCACTTC Pst I 589 Forward AAAAAAGAATTC-Eco RI ATGCAACAAAAAATCCGTTTCCAAATCGAAGG ReverseAAAAAACTGCAG-CTAATCGATTTTTACCCGTTTCAGGCG Pst I 590 ForwardAAAAAAGAATTC-ATGAAAAAACCTTTGATTTCAGTTGCGGC Eco RI ReverseAAAAAACTGCAG-TTACTGCTGCGGCTCTGAAACCAT Pst I 591 ForwardAAAAAAGAATTC-CACTACATCGTTGCCAGATTGTGCGG Eco RI ReverseAAAAAACTGCAG-CTAACCGAGCAGCCGGGTAACGTCGTT Pst I 592a ForwardAAAAAAGAATTC-CGCGATTACACCGCCAAGCTGAAAATGGG Eco RI ReverseAAAAAACTGCAG-TTACCAAACGTCGGATTTGATACG Pst I 593 ForwardCGCGGATCCGCTAGC-CTTGAACTGAACGGACTC BamHI- NheI ReverseCCCGCTCGAG-GCGGAAGCGGACGATT XhoI 594a ForwardAAAAAAGAATTC-GGTAAGTTCGCCGTTCAGGCCTTTCA Eco RI ReverseAAAAAACTGCAG-TTACGCCGCCGTTTCCTGACACTCGCG Pst I 595 ForwardAAAAAAGAATTC-TGCCAGCCGCCGGAGGCGGAGAAAGC Eco RI ReverseAAAAAACTGCAG-TTATTTCAAGCCGAGTATGCCGCG Pst I 596 ForwardCGCGGATCCCATATG-TCCCAACAATACGTC BamHI- NdeI ReverseCCCGCTCGAG-ACGCGTTACCGGTTTGT XhoI 597 ForwardCGCGGATCCCATATG-CTGCTTCATGTCAGC BamHI- NdeI ReverseGCCCAAGCTT-ACGTATCCAGCTCGAAG HindIII 601 ForwardCGCGGATCCCATATG-ATATGTTCCCAACCGGCAAT BamHI- NdeI ReverseCCCGCTCGAG-AAAACAATCCTCAGGCAC XhoI 602 ForwardCGCGGATCCGCTAGC-TTGCTCCATCAATGC BamHI- NheI ReverseCCCGCTCGAG-ATGCAGCTGCTAAAAGCG XhoI 603 ForwardAAAAAAGAATTC-CTGTCCTCGCGTAGGCGGGGACGGGG Eco RI ReverseAAAAAACTGCAG-CTACAAGATGCCGGCAAGTTCGGC Pst I 604 ForwardCGCGGATCCGCTAGC-CCCGAAGCGCACTT BamHI- NheI ReverseCCCGCTCGAG-GACGGCATCTGCACGG XhoI 606a ForwardAAAAAAGAATTC-CGCGAATACCGCGCCGATGCGGGCGC Eco RI ReverseAAAAAACTGCAG-TTAAAGCGATTTGAGGCGGGCGATACG Pst I 607 ForwardAAAAAAGAATTC-ATGCTGCTCGACCTCAACCGCTTTTC Eco RI ReverseAAAAAACTGCAG-TCAGACGGCCTTATGCGATCTGAC Pst I 608 ForwardAAAAAAGAATTC-ATGTCCGCCCTCCTCCCCATCATCAACCG Eco RI ReverseAAAAAACTGCAG-TTAGTCTATCCAAATGTCGCGTTC Pst I 609 ForwardCGCGGATCCCATATG-GTTGTGGATAGACTCG BamHI- NdeI ReverseCCCGCTCGAG-CTGGATTATGATGTCTGTC XhoI 610 ForwardCGCGGATCCCATATG-ATTGGAGGGCTTATGCA BamHI- NdeI ReverseCCCGCTCGAG-ACGCTTCAACATCTTTGCC XhoI 611 ForwardCGCGGATCCCATATG-CCGTCTCAAAACGGG BamHI- NdeI ReverseCCCGCTCGAG-AACGACTTTGAACGCGCAA XhoI 613 ForwardCGCGGATCCCATATG-TCGCGTTCGAGCCG3 BamHI- NdeI ReverseCCCGCTCGAG-AGCCTGTAAAATAAGCGGC XhoI 614 ForwardCGCGGATCCCATATG-TCCGTCGTGAGCGGC BamHI- NdeI ReverseCCCGCTCGAG-CCATACTGCGGCGTTC XhoI 616 ForwardAAAAAAGAATTC-ATGTCAAACACAATCAAAATGGTTGTCGG Eco RI ReverseAAAAAATCTAGA-TTAGTCCGGGCGGCAGGCAGCTCG Xba I 619a ForwardAAAAAAGAATTC-GGGCTTCTCGCCGCCTCGCTTGC Eco RI ReverseAAAAAACTGCAG-TCATTTTTTGTGTTTTAAAACGAGATA Pst I 622 ForwardCGCGGATCCCATATG-GCCGCCCTGCCTAAAG BamHI- NdeI ReverseCCCGCTCGAG-TTTGTCCAAATGATAAATCTG XhoI 624 ForwardCGCGGATCCCATATG-TCCCCGCGCTTTTACCG BamHI- NdeI ReverseCCCGCTCGAG-AGATTCGGGCCTGCGC XhoI 625 ForwardCGCGGATCCCATATG-TTTGCAACCAGGAAAATG BamHI- NdeI ReverseCCCGCTCGAG-CGGCAAAATTACCGCCTT XhoI 627a ForwardAAAAAAGAATTC-AAAGCAGGCGAGGCAGGCGCGCTGGG Eco RI Reverse AAAAAACTGCAG- PstI TTACGAATGAAACAGGGTACCCGTCATCAAGGC 628 ForwardAAAAAAGGTACC-GCCTTACAAACATGGATTTTGCGTTC Kpn I ReverseAAAAAACTGCAG-CTACGCACCTGAAGCGCTGGCAAA Pst I 629a ForwardAAAAAAGAATTC-GCCACCTTTATCGCGTATGAAAACGA Eco RI ReverseAAAAAACTGCAG-TTACAACACCGCCGTCCGGTTCAAACC Pst I 630a ForwardAAAAAAGAATTC-GCGGCTTTGGGTATTTCTTTCGG Eco RI ReverseAAAAAACTGCAG-TTAGGAGACTTCGCCAATGGAGCCGGG Pst I 635 Forward AAAAAAGAATTC-Eco RI ATGACCCAGCGACGGGTCGGCAAGCAAAACCG ReverseAAAAAACTGCAG-TTAATCCACTATAATCCTGTTGCT Pst I 638 ForwardAAAAAAGAATTC-ATGATTGGCGAAAAGTTTATCGTAGTTGG Eco RI ReverseAAAAAACTGCAG-TCACGAACCGATTATGCTGATCGG Pst I 639 ForwardCGCGGATCCCATATG-ATGCTTTATTTTGTTCG BamHI- NdeI ReverseCCCGCTCGAG-ATCGCGGCTGCCGAC XhoI 642 ForwardCGCGGATCCCATATG-CGGTATCCGCCGCAAT BamHI- NdeI ReverseCCCGCTCGAG-AGGATTGCGGGGCATTA XhoI 643 ForwardCGCGGATCCCATATG-GCTTCGCCGTCGGCAG BamHI- NdeI ReverseCCCGCTCGAG-AACCGAAAAACAGACCGC XhoI 644 Forward AAAAAAGAATTC- Eco RIATGCCGTCTGAAAGGTCGGCGGATTGTTGCCC ReverseAAAAAATCTAGA-CTACCCGCAATATCGGCAGTCCAATAT Pst I 645 ForwardAAAAAAGAATTC-GTGGAACAGAGCAACACGTTAAATCG Eco RI ReverseAAAAAACTGCAG-CTACGAGGAAACCGAAGACCAGGCCGC Pst I 647 ForwardAAAAAAGAATTC-ATGCAAAGGCTCGCCGCAGACGG Eco RI ReverseAAAAAACTGCAG-TTAGATTATCAGGGATATCCGGTAGAA Pst I 648 Forward AAAAAAGAATTC-Eco RI ATGAACAGGCGCGACGCGCGGATCGAACG ReverseAAAAAACTGCAG-TCAAGCTGTGTGCTGATTGAATGCGAC Pst I 649 ForwardAAAAAAGAATTC-GGTACGTCAGAACCCGCCCACCG Eco RI ReverseAAAAAACTGCAG-TTAACGGCGGAAACTGCCGCCGTC Pst I 650 ForwardAAAAAAGAATTC-ATGTCCAAACTCAAAACCATCGC Eco RI ReverseAAAAAACTGCAG-TCAGACGGCATGGCGGTCTGTTTT Pst I 652 Forward AAAAAAGGTACC-Kpn I GCTGCCGAAGACTCAGGCCTGCCGCTTTACCG ReverseAAAAAACTGCAG-TTATTTGCCCAGTTGGTAGAATGCGGC Pst I 653 ForwardAAAAAAGAATTC-GCGGCTTTGCCGGTAATTTTCATCGG Eco RI ReverseAAAAAACTGCAG-CTATGCCGGTCTGGTTGCCGGCGGCGA Pst I 656a ForwardAAAAAAGAATTC-CGGCCGACGTCGTTGCGTCCTAAGTC Eco RI ReverseAAAAAACTGCAG-CTACGATTTCGGCGATTTCCACATCGT Pst I 657 ForwardAAAAAAGAATTC-GCAGAATTTGCCGACCGCCATTTGTGCGC Eco RI ReverseAAAAAACTGCAG-TTATAGGGACTGATGCAGTTTTTTTGC Pst I 658 ForwardCGCGGATCCCATATG-GTGTCCGGAATTGTG BamHI- NdeI ReverseCCCGCTCGAG-GGCAGAATGTTTACCGTT XhoI 661 Forward AAAAAAGAATTC- Eco RIATGCACATCGGCGGCTATTTTATCGACAACCC ReverseAAAAAACTGCAG-TCACGACGTGTCTGTTCGCCGTCGGGC Pst I 663 ForwardCGCGGATCCCATATG-TGTATCGAGATGAAATT BamHI- NdeI ReverseCCCGCTCGAG-GTAAAAATCGGGGCTGC XhoI 664 ForwardCGCGGATCCCATATG-GCGGCTGGCGCGGT BamHI- NdeI ReverseCCCGCTCGAG-AAATCGAGTTTTACACCAC XhoI 665 ForwardAAAAAAGAATTC-ATGAAATGGGACGAAACGCGCTTCGG Eco RI ReverseAAAAAACTGCAG-TCAATCCAAAATTTTGCCGACGATTTC Pst I 666 ForwardAAAAAAGAATTC-AACTCAGGCGAAGGAGTGCTTGTGGC Eco RI ReverseAAAAAATCTAGA-TCAGTTTAGGGATAGCAGGCGTAC Xba I 667 Forward AAAAAAGAATTC-Eco RI CCGCATCCGTTTGATTTCCATTTCGTATTCGTCCG ReverseAAAAAACTGCAG-TTAATGACACAATAGGCGCAAGTC Pst I 669 ForwardAAAAAAGAATTC-ATGCGCCGCATCATTAAAAAACACCAGCC Eco RI ReverseAAAAAACTGCAG-TTACAGTATCCGTTTGATGTCGGC Pst I 670a ForwardAAAAAAGAATTC-AAAAACGCTTCGGGCGTTTCGTCTTC Eco RI Reverse AAAAAACTGCAG- PstI TTAGGAGCTTTTGGAACGCGTCGGACTGGC 671 ForwardCGCGGATCCCATATG-ACCAGCAGGGTAAC BamHI- NdeI ReverseCCCGCTCGAG-AGCAACTATAAAAACGCAAG XhoI 672 ForwardCGCGGATCCCATATG-AGGAAAATCCGCACC BamHI- NdeI ReverseCCCGCTCGAG-ACGGGATAGGCGGTTG XhoI 673 ForwardAAAAAAGAATTC-ATGGATATTGAAACCTTCCTTGCAGG Eco RI ReverseAAAAAACTGCAG-CTACAAACCCAGCTCGCGCAGGAA Pst I 674 ForwardAAAAAAGAATTC-ATGAAAACAGCCCGCCGCCGTTCCCG Eco RI ReverseAAAAAACTGCAG-TCAACGGCGTTTGGGCTCGTCGGG Pst I 675 ForwardCGCGGATCCCATATG-AACACCATCGCCCC BamHI- NdeI ReverseCCCGCTCGAG-TTCTTCGTCTTCAAACTGT XhoI 677a ForwardAAAAAAGAATTC-AGACGGCATTCCCGATCAGTCGATTTTGA Eco RI ReverseAAAAAACTGCAG-TTACGTATGCGCGAAATCGACCGCCGC Pst I 680 ForwardCGCGGATCCGCTAGC-ACGAAGGGCAGTTCGG BamHI- NheI ReverseCCCGCTCGAG-CATCAAAAACCTGCCGC XhoI 681 ForwardAAAAAAGAATTC-ATGACGACGCCGATGGCAATCAGTGC Eco RI ReverseAAAAAACTGCAG-TTACCGTCTTCCGCAAAAAACAGC Pst I 683 ForwardCGCGGATCCCATATG-TGCAGCACACCGGACAA BamHI- NdeI ReverseCCCGCTCGAG-GAGTTTTTTTCCGCATACG XhoI 684 ForwardCGCGGATCCCATATG-TGCGGTACTGTGCAAAG BamHI- NdeI ReverseCCCGCTCGAG-CTCGACCATCTGTTGCG XhoI 685 ForwardCGCGGATCCCATATG-TGTTTGCTTAATAATAAACATT BamHI- NdeI ReverseCCCGCTCGAG-CTTTTTCCCCGCCGCA XhoI 686 ForwardCGCGGATCCCATATG-TGCGGCGGTTCGGAAG BamHI- NdeI ReverseCCCGCTCGAG-CATTCCGATTCTGATGAAG XhoI 687 ForwardCGCGGATCCCATATG-TGCGACAGCAAAGTCCA BamHI- NdeI ReverseCCCGCTCGAG-CTGCGCGGCTTTTTGTT XhoI 690 ForwardCGCGGATCCCATATG-TGTTCTCCGAGCAAAGAC BamHI- NdeI ReverseCCCGCTCGAG-TATTCGCCCCGTGTTTGG XhoI 691 ForwardCGCGGATCCCATATG-GCCACGGCTTATATCCC BamHI- NdeI ReverseCCCGCTCGAG-TTTGAGGCAGGAAGAAAG XhoI 694 ForwardCGCGGATCCCATATG-TTGGTTTCCGCATCCGG BamHI- NdeI ReverseCCCGCTCGAG-TCTGCGTCGGTGCGGT XhoI 695 ForwardCGCGGATCCCATATG-TTGCCTCAAACTCGTCCG BamHI- NdeI ReverseCCCGCTCGAG-TCGTTTGCGCACGGCT XhoI 696 ForwardCGCGGATCCCATATG-TTGGGTTGCCGGCAGG BamHI- NdeI ReverseCCCGCTCGAG-TTGATTGCCGCAATGATG XhoI 700a ForwardAAAAAAGAATTC-GCATCGACAGACGGTGTGTCGTGGAC Eco RI ReverseAAAAAACTGCAG-TTACGCTACCGGCACGACTTCCAAACC Pst I 701 ForwardCGCGGATCCCATATG-AAGACTTGTTTGGATACTTC BamHI- NdeI ReverseCCCGCTCGAG-TGCCGACAACAGCCTC XhoI 702 ForwardAAAAAAGAATTC-ATGCCGTGTTCCAAAGCCAGTTGGATTTC Eco RI ReverseAAAAAACTGCAG-TTAACCCCATTCCACCCGGAGAACCGA Pst I 703 ForwardCGCGGATCCGCTAGC-CAAACGCTGGCAACCG BamHI- NheI ReverseCCCGCTCGAG-TTTTGCAGGTTTGATGTTTG XhoI 704a ForwardAAAAAAGAATTC-GCTTCTACCGGTACGCTGGCGCG Eco RI Reverse AAAAAACTGCAG- Pst ITTAGTTTTGCCGGATAATATGGCGGGTGCG 707 ForwardCGCGGATCCGCTAGC-GAAATTATTAACGATGCAGA BamHI- NheI ReverseCCCGCTCGAG-GAAACTGTAATTCAAGTTGA XhoI 708 ForwardCGCGGATCCGCTAGC-CCTTTTAAGCCATCCAAAA BamHI- NheI ReverseCCCGCTCGAG-TTGACCGGTGAGGACG XhoI 710 ForwardCGCGGATCCCATATG-GAAACCCACGAAAAAATC BamHI- NdeI ReverseCCCGCTCGAG-AACGGTTTCGGTCAG XhoI 714 ForwardCGCGGATCCCATATG-AGCTATCAAGACATCTT BamHI- NdeI ReverseCCCGCTCGAG-GCGGTAGGTAAATCGGAT XhoI 716 ForwardCGCGGATCCCATATG-GCCAACAAACCGGCAAG BamHI- NdeI ReverseCCCGCTCGAG-TTTAGAACCGCATTTGCC XhoI 718 ForwardCGCGGATCCCATATG-GAGCCGATAATGGCAAA BamHI- NdeI ReverseCCCGCTCGAG-GGCGCGGGCATGGTCTTGTCC XhoI 720 ForwardCGCGGATCCCATATG-AGCGGATGGCATACC BamHI- NdeI ReverseCCCGCTCGAG-TTTTGCATAGCTGTTGACCA XhoI 723 ForwardCGCGGATCCCATATG-CGACCCAAGCCCC BamHI- NdeI ReverseCCCGCTCGAG-AATGCGAATCCGCCGCC XhoI 725 ForwardCGCGGATCCCATATG-GTGCGCACGGTTAAA BamHI- NdeI ReverseCCCGCTCGAG-TTGCTTATCCTTAAGGGTTA XhoI 726 ForwardCGCGGATCCCATATG-ACCATCTATTTCAAAAAC BamHI- NdeI ReverseCCCGCTCGAG-GCCGATGTTTAGCGTCC XhoI 728 ForwardCGCGGATCCCATATG-TTTTGGCTGGGAACGGG BamHI- NdeI ReverseCCCGCTCGAG-GTGAGAAAGGTCGCGC XhoI 729 ForwardCGCGGATCCCATATG-TGCACCATGATTCCCCA BamHI- NdeI ReverseGCCCAAGCTT-TTTGTCGGTTTGGGTATC HindIII 731 ForwardCGCGGATCCGCTAGC-GCCGTGCCGGAGG BamHI- NheI ReverseCCCGCTCGAG-ACGGGCGCGGCAG XhoI 732 ForwardCCGGAATTCTACATATG-TCGAAACCTGTTTTTAAGAA EcoRI- NdeI ReverseCCCGCTCGAG-CTTCTTATCTTTTTTATCTTTC XhoI 733 ForwardCGCGGATCCCATATG-GCCTGCGGCGGCAA BamHI- NdeI ReverseCCCGCTCGAG-TCGCTTGCCTCCTTTAC XhoI 734 ForwardCGCGGATCCCATATG-GCCGATACTTACGGCTAT BamHI- NdeI ReverseCCCGCTCGAG-TTTGAGATTTTGAATCAAAGAG XhoI 735 ForwardCGCGGATCCCATATG-AAGCAGCAGGCGGTCA BamHI- NdeI ReverseCCCGCTCGAG-ATTTCCGTAGCCGAGGG XhoI 737 ForwardCGCGGATCCCATATG-CACCACGACGGACACG BamHI- NdeI ReverseCCCGCTCGAG-GTCGTCGCGGCGGGA XhoI 739 ForwardCGCGGATCCCATATG-GCAAAAAAACCGAACA BamHI- NdeI ReverseCCCGCTCGAG-GAAGAGTTTGTCGAGAATT XhoI 740 ForwardCGCGGATCCCATATG-GCCAATCCGCCCGAAG BamHI- NdeI ReverseCCCGCTCGAG-AAACGCGCCAAAATAGTG XhoI 741 ForwardCGCGGATCCCATATG-TGCAGCAGCGGAGGG BamHI- NdeI ReverseCCCGCTCGAG-TTGCTTGGCGGCAAGGC XhoI 743 ForwardCGCGGATCCCATATG-GACGGTGTTGTGCCTGTT BamHI- NdeI ReverseCCCGCTCGAG-CTTACGGATCAAATTGACG XhoI 745 ForwardCGCGGATCCCATATG-TTTTGGCAACTGACCG BamHI- NdeI ReverseCCCGCTCGAG-CAAATCAGATGCCTTTAGG XhoI 746 ForwardCGCGGATCCCATATG-TCCGAAAACAAACAAAAC BamHI- NdeI ReverseCCCGCTCGAG-TTCATTCGTTACCTGACC XhoI 747 ForwardCCGGAATTCTAGCTAGC-CTGACCCCTTGGG EcoRI- NheI ReverseGCCCAAGCTT-TTTTGATTTTAATTGACTATAGAAC HindIII 749 ForwardCGCGGATCCCATATG-TGCCAGCCGCCG BamHI- NdeI ReverseCCCGCTCGAG-TTTCAAGCCGAGTATGC XhoI 750 ForwardCGCGGATCCCATATG-TGTTCGCCCGAACCTG BamHI- NdeI ReverseCCCGCTCGAG-CTTTTTCCCCGCCGCAA XhoI 758 ForwardCGCGGATCCCATATG-AACAATCTGACCGTGTT BamHI- NdeI ReverseCCCGCTCGAG-TGGCTCAATCCTTTCTGC XhoI 759 ForwardCGCGGATCCGCTAGC-CGCTTCACACACACCAC BamHI- NheI ReverseCCCGCTCGAG-CCAGTTGTAGCCTATTTTG XhoI 763 ForwardCGCGGATCCCATATG-CTGCCTGAAGCATGGCG BamHI- NdeI ReverseCCCGCTCGAG-TTCCGCAAATACCGTTTCC XhoI 764 ForwardCGCGGATCCCATATG-TTTTTCTCCGCCCTGA BamHI- NdeI ReverseCCCGCTCGAG-TCGCTCCCTAAAGCTTTC XhoI 765 ForwardCGCGGATCCCATATG-TTAAGATGCCGTCCG BamHI- NdeI ReverseCCCGCTCGAG-ACGCCGACGTTTTTTATTAA XhoI 767 ForwardCGCGGATCCCATATG-CTGACGGAAGGGGAAG BamHI- NdeI ReverseCCCGCTCGAG-TTTCTGTACAGCAGGGG XhoI 768 ForwardCGCGGATCCCATATG-GCCCCGCAAAAACCCG BamHI- NdeI ReverseCCCGCTCGAG-TTTCATCCCTTTTTTGAGC XhoI 770 ForwardCGCGGATCCCATATG-TGCGGCAGCGGCGAA BamHI- NdeI ReverseCCCGCTCGAG-GCGTTTGTCGAGATTTTC XhoI 771 ForwardCGCGGATCCCATATG-TCCGTATATCGCACCTTC BamHI- NdeI ReverseCCCGCTCGAG-CGGTTCTTTAGGTTTGAG XhoI 772 ForwardCGCGGATCCCATATG-TTTGCGGCGTTGGTGG BamHI- NdeI ReverseCCCGCTCGAG-CAATGCCGACATCAAACG XhoI 774 ForwardCGCGGATCCCATATG-TCCGTTTCACCCGTTCC BamHI- NdeI ReverseCCCGCTCGAG-TCGTTTGCGCACGGCT XhoI 790 ForwardCGCGGATCCCATATG-GCAAGAAGGTCAAAAAC BamHI- NdeI ReverseCCCGCTCGAG-GGCGTTGTTCGGATTTCG XhoI 900 ForwardCGCGGATCCCATATG-CCGTCTGAAATGCCG BamHI- NdeI ReverseCCCGCTCGAG-ATATGGAAAAGTCTGTTGTC XhoI 901 ForwardCGCGGATCCCATATG-CCCGATTTTTCGATG BamHI- NdeI ReverseCCCGCTCGAG-AAAATGGAACAATACCAGG XhoI 902 Forward.2CCGGAATTCTACATATG-TTGCACTTTCAAAGGATAATC EcoRI- NdeI ReverseCCCGCTCGAG-AAAAATGTACAATGGCGTAC XhoI 903 ForwardCCGGAATTCTAGCTAGC-CAGCGTCAGCAGCACAT EcoRI- NheI ReverseCCCGCTCGAG-GAAACTGTAATTCAAGTTGAA XhoI 904 ForwardAAAAAAGGTACC-ATGATGCAGCACAATCGTTTC Kpn I ReverseAAACTGCAG-TTAATATCGATAGGTTATATG Pst I 904a ForwardAAAAAAGAATTC-CGGCTCGGCATTGTGCAGATGTTGCA Eco RI ReverseAAACTGCAG-TTAATATCGATAGGTTATATG Pst I 905 ForwardCGCGGATCCCATATG-AACAAAATATACCGCATC BamHI- NdeI ReverseCCCGCTCGAG-CCACTGATAACCGACAGAT XhoI 907 ForwardCGCGGATCCCATATG-GGCGCGCAACGTGAG BamHI- NdeI ReverseCCCGCTCGAG-ACGCCACTGCCAGCG XhoI 908 ForwardAAAGAATTC-GCAGAGTTAGTAGGCGTTAATAAAAATAC Eco RI ReverseAAACTGCAG-TTAATATGGTTTTGTCGTTCG Pst I 909 ForwardCGCGGATCCCATATG-TGCGCGTGGGAAACTTAT BamHI- NdeI ReverseCCCGCTCGAG-TCGGTTTTGAAACTTTGGTTTT XhoI 910 ForwardAAAGAATTC-GCATTTGCCGGCGACTCTGCCGAGCG Eco RI ReverseAAACTGCAG-TCAGCGATCGAGCTGCTCTTT Pst I 911 ForwardAAAGAATTC-GCTTTCCGCGTGGCCGGCGGTGC Eco RI ReverseAAAAAACTGCAG-GTCGACTTATTCGGCGGCTTTTTCCGC Pst I 912 Forward AAAAAAGAATTC-Eco RI CAAATCCGTCAAAACGCCACTCAAGTATTGAG ReverseAAAAAACTGCAG-TTACAGTCCGTCCACGCCTTTCGC Pst I 913 ForwardCGCGGATCCCATATG-GAAACCCGCCCCGC BamHI- NdeI ReverseCCCGCTCGAG-AGGTTGTGTTCCAGGTTG XhoI 915 ForwardCGCGGATCCCATATG-TGCCGGCAGGCGGAA BamHI- NdeI ReverseCCCGCTCGAG-TTTGAAAATATAGGTATCAGG XhoI 914 ForwardAAAGAATTC-GACAGAATCGGCGATTTGGAAGCACG Eco RI ReverseAAACTGCAG-CTATATGCGCGGCAGGACGCTCAACGG Pst I 916 ForwardCGCGGATCCCATATG-GCAATGATGGCGGCTG BamHI- NdeI ReverseCCCGCTCGAG-TTTGGCGGCATCTTTCAT XhoI 917 ForwardAAAAAAGAATTC-CCTGCCGAAAAACCGGCACCGGC Eco RI ReverseAAAAAACTGCAG-TTATTTCCCCGCCTTCACATCCTG Pst I 919 ForwardCGCGGATCCCATATG-TGCCAAAGCAAGAGCATC BamHI- NdeI ReverseCCCGCTCGAG-CGGGCGGTATTCGGG XhoI 920 ForwardCGCGGATCCCATATG-CACCGCGTCTGGGTC BamHI- NdeI ReverseCCCGCTCGAG-ATGGTGCGAATGACCGA XhoI 921 ForwardAAAAAAGAATTC-TTGACGGAAATCCCCGTGAATCC Eco RI ReverseAAAAAACTGCAG-TCATTTCAAGGGCTGCATCTTCAT Pst I 922 Forward.2CGCGGATCCGCTAGC-TGTACGGCGATGGAGGC BamHI- NheI ReverseCCCGCTCGAG-CAATCCCGGGCCGCC XhoI 923 ForwardCGCGGATCCCATATG-TGTTACGCAATATTGTCCC BamHI- NheI ReverseCCCGCTCGAG-GGACAAGGCGACGAAG XhoI 925 ForwardCGCGGATCCCATATG-AAACAAATGCTTTTAGCCG BamHI- NdeI ReverseCCCGCTCGAG-GCCGTTGCATTTGATTTC XhoI 926 ForwardCGCGGATCCCATATG-TGCGCGCAATTACCTC BamHI- NdeI ReverseCCCGCTCGAG-TCTCGTGCGCGCCG XhoI 927 ForwardCGCGGATCCCATATG-TGCAGCCCCGCAGC BamHI- NdeI ReverseCCCGCTCGAG-GTTTTTTGCTGACGTAGT XhoI 929a ForwardAAAAAAGAATTC-CGCGGTTTGCTCAAAACAGGGCTGGG Eco RI ReverseAAAAAATCTAGA-TTAAGAAAGACGGAAACTACTGCC Xba I 931 ForwardAAAAAAGAATTC-GCAACCCATGTTTTGATGGAAAC Eco RI ReverseAAAAAACTGCAG-TTACTGCCCGACAACAACGCGACG Pst I 935 Forward AAAAAAGAATTC-Eco RI GCGGATGCGCCCGCGATTTTGGATGACAAGGC ReverseAAAAAACTGCAG-TCAAAACCGCCAATCCGCCGACAC Pst I 936 ForwardCGCGGATCCCATATG-GCCGCCGTCGGCGC BamHI- NdeI ReverseCCCGCTCGAG-GCGTTGGACGTAGTTTTG XhoI 937 ForwardAAAAAAGAATTC-CCGGTTTACATTCAAACCGGCGCAAC Eco RI ReverseAAAAAACTGCAG-TTAAAATGTATGCTGTACGCCAAA Pst I 939a ForwardAAAAAAGAATTC-GGTTCGGCAGCTGTGATGAAACC Eco RI ReverseAAAAAACTGCAG-TTAACGCAAACCTTGGATAAAGTTGGC Pst I 950 ForwardCGCGGATCCCATATG-GCCAACAAACCGGCAAG BamHI- NdeI ReverseCCCGCTCGAG-TTTAGAACCGCATTTGCC XhoI 953 ForwardCGCGGATCCCATATG-GCCACCTACAAAGTGGAC BamHI- NdeI ReverseCCCGCTCGAG-TTGTTTGGCTGCCTCGAT XhoI 957 ForwardCGCGGATCCCATATG-TTTTGGCTGGGAACGGG BamHI- NdeI ReverseCCCGCTCGAG-GTGAGAAAGGTCGCGC XhoI 958 ForwardCGCGGATCCCATATG-GCCGATGCCGTTGCG BamHI- NdeI ReverseGCCCAAGCTT-GGGTCGTTTGTTGCGTC HindIII 959 ForwardCGCGGATCCCATATG-CACCACGACGGACACG BamHI- NdeI ReverseCCCGCTCGAG-GTCGTCGCGGCGGGA XhoI 961 ForwardCGCGGATCCCATATG-GCCACAAGCGACGACG BamHI- NdeI ReverseCCCGCTCGAG-CCACTCGTAATTGACGC XhoI 972 Forward AAAAAAGAATTC- Eco RITTGACTAACAGGGGGGGAGCGAAATTAAAAAC ReverseAAAAAATCTAGA-TTAAAAATAATCATAATCTACATTTTG Xba I 973 ForwardAAAAAAGAATTC-ATGGACGGCGCACAACCGAAAAC Eco RI ReverseAAAAAACTGCAG-TTACTTCACGCGGGTCGCCATCAGCGT Pst I 982 ForwardCGCGGATCCCATATG-GCAGCAAAAGACGTAC BamHI- NdeI ReverseCCCGCTCGAG-CATCATGCCGCCCATCC XhoI 983 ForwardCGCGGATCCCATATG-TTAGCTGTTGCAACAACAC BamHI- NdeI ReverseCCCGCTCGAG-GAACCGGTAGCCTACG XhoI 987 ForwardCGCGGATCCCATATG-CCCCCACTGGAAGAAC BamHI- NdeI ReverseCCCGCTCGAG-TAATAAACCTTCTATGGGC XhoI 988 ForwardCGCGGATCCCATATG-TCTTTAAATTTACGGGAAAAAG BamHI- NdeI ReverseGCCCAAGCTT-TGATTTGCCTTTCCGTTTT HindIII 989 ForwardCCGGAATTCTACATATG-GTCCACGCATCCGGCTA EcoRI- NdeI ReverseCCCGCTCGAG-TTTGAATTTGTAGGTGTATTGC XhoI 990 Forward.2CGCGGATCCGCTAGC-TTCAGAGCTCAGCTT BamHI- NheI ReverseCCCGCTCGAG-AAACAGCCATTTGAGCGA XhoI 992 ForwardCGCGGATCCCATATG-GACGCGCCCGCCCG BamHI- NdeI ReverseCCCGCTCGAG-CCAAATGCCCAACCATTC XhoI 993 ForwardCGCGGATCCCATATG-GCAATGCTGATTGAAATCA BamHI- NdeI ReverseCCCGCTCGAG-GAACACATCGCGCCCG XhoI 996 ForwardCGCGGATCCCATATG-TGCGGCAGAAAATCCGC BamHI- NdeI ReverseCCCGCTCGAG-TCTAAACCCCTGTTTTCTC XhoI 997 ForwardCCGGAATTCTAGCTAGC-CGGCACGCCGACGTT EcoRI- NheI ReverseCCCGCTCGAG-GACGGCATCGCTCAGG XhoIUnderlined sequences indicate restriction recognition sites.

The following DNA and amino acid sequences are identified by titles ofthe following form: [g, m, or a] [#].[seq or pep], where “g” means asequence from N. gonorrhoeae, “m” means a sequence from N. meningitidisB, and “a” means a sequence from N. meningitidis A; “#” means the numberof the sequence; “seq” means a DNA sequence, and “pep” means an aminoacid sequence. For example, “g001.seq” refers to an N. gonorrohoeae DNAsequence, number 1. The presence of the suffix “−1” to these sequencesindicates an additional sequence found for the same ORF. Further, openreading frames are identified as ORF #, where “#” means the number ofthe ORF, corresponding to the number of the sequence which encodes theORF, and the ORF designations may be suffixed with “.ng” or “.a”,indicating that the ORF corresponds to a N. gonorrhoeae sequence or a N.meningitidis A sequence, respectively. Computer analysis was performedfor the comparisons that follow between “g”, “m”, and “a” peptidesequences; and therein the “pep” suffix is implied where not expresslystated.

The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1>:

g001.seq 1 ATGCTGCCGC AGGGGAAGGC GGCGCGGAGG GTGTCGGCGA ACGAGGTGTC 51CGGCAGGGCT TGCGCCCGGA TGGTGCTGGT CATCTGCCAG ACGCTGCCGA 101 AACGCGATACTTTAAACGGC TCGGGTACGC ATACTTTACC GGTTTGGGCG 151 ATTTTGCCGA GGTCGTTGCGCAGCAAATCG ACAATCATCA CGTTTTCGGC 201 GCGGTTTTTC GGGTCGGTTT GTAACTCGGCGGCGCGGCGT TCGTCTTGTC 251 CGTCGCCCAA AATCGGCGCG GTGCCTTTCA TCGGTTCGGTGCTGATGGTG 301 CCGTCTGAAG CGATGTTGAG GAAGAGTTCG GGCGAGAAAC ACAGCGTCCA351 CGCGGATTGC CCGGCTTCAT CGGGCAGGTG GGACAATACG GCATAGThis corresponds to the amino acid sequence <SEQ ID 2; ORF 001.ng>:

g001.pep 1 MLPQGKAARR VSANEVSGRA CARMVLVICQ TLPKRDTLNG SGTHTLPVWA 51ILPRSLRSKS TIITFSARFF GSVCNSAARR SSCPSPKIGA VPFIGSVLMV 101 PSEAMLRKSSGEKHSVHADC PASSGRWDNT A*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3>:

m001.seq 1 ATGCTGCCGC AGGGGAAGGC GGCGCGGAGG ATGTCGGCGA ACGAGGTGTG 51CGGcAssCTT ss.GCTTGGA yGGTGCTGGT CATCTGCCAA ACGCTGCCGA 101 AACGCGATACTTTAAACGGT TCGGGTACGC ATACTGTGCC GGTTTGGGCG 151 ATTTTGCCGA GATCGTTACGCAGCAAATCG ACAATCATCA CGTTTTCGGC 201 GCGGTTTTTC GGGTCTGCTT GCAACTCGGCGGCGCGGCGT TCGTCTTGTC 251 CGTCGCCCAA AATCGGCGCG GTGCCTTTCA TCGGTTCGGTGCTGATGGTG 301 CCGTCCGAAC CGATTTTGAG GAAGAGTTCG GGCGAGAAAC ACAGCGTCCA351 CGCGGATTGC CCCTCCGCAT CGGGCAGGTG GGACAAGACG GCATAGThis corresponds to the amino acid sequence <SEQ ID 4; ORF 001>:

m001.pep 1 MLPQGKAARR MSANEVCGXL XAWXVLVICQ TLPKRDTLNG SGTHTVPVWA 51ILPRSLRSKS TIITFSARFF GSACNSAARR SSCPSPKIGA VPFIGSVLMV 101 PSEPILRKSSGEKHSVHADC PSASGRWDKT A*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 5>:

a001.seq 1 ATGCTGCCGC AGGGGAAGGC GGCGCGGAGG ATGTCGGCGA ACGAGGTGTG 51CGGCAAGGCT TGGGCTTGGA TGGTGCTGGT CATCTGCCAA ACGCTGCCGA 101 AACGCGATACTTTAAACGGT TCGGGTACGC ATACTGTGCC GGTTTGGGCG 151 ATTTTGCCGA GGTCGTTACGCAGCAAATCG ACAATCATCA CGTTTTCGGC 201 GCGGTTTTTC GGGTCTGCTT GCAACTCGGCGGCGCGGCGT TCGTCTTGTC 251 CGTCGCCCAA AATCGGCGCG GTGCCTTTCA TCGGTTCGGTGCTGATGGTG 301 CCGTCCGAAC CGATTTTGAG GAAGAGTTCG GGCGAGAAAC ACAGCGTCCA351 CGCGGATTGC CCTTGTGCAT CGGGCAGGTG GGACAAAACG GCATAGThis corresponds to the amino acid sequence <SEQ ID 6; ORF 001.a>:

a001.pep 1 MLPQGKAARR MSANEVCGKA WAWMVLVICQ TLPKRDTLNG SGTHTVPVWA 51ILPRSLRSKS TIITFSARFF GSACNSAARR SSCPSPKIGA VPFIGSVLMV 101 PSEPILRKSSGEKHSVHADC PCASGRWDKT A* m001/a001 96.2% identity over a 131 aa overlap        10        20        30        40        50        60 m001.pepMLPQGKAARRMSANEVCGXLXAWXVLVICQTLPKRDTLNGSGTHTVPVWAILPRSLRSKS||||||||||||||||||   || |||||||||||||||||||||||||||||||||||| a001.pepMLPQGKAARRMSANEVCGKAWAWMVLVICQTLPKRDTLNGSGTHTVPVWAILPRSLRSKS        10        20        30        40        50        60        70        80        90       100       110       120 m001.pepTIITFSARFFGSACNSAARRSSCPSPKIGAVPFIGSVLMVPSEPILRKSSGEKHSVHADC|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a001.pepTIITFSARFFGSACNSAARRSSCPSPKIGAVPFIGSVLMVPSEPILRKSSGEKHSVHADC        70        80        90       100       110       120        130m001.pep PSASGRWDKTAX | |||||||||| a001.pep PCASGRWDKTAX        130Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 001 shows 89.3% identity over a 131 aa overlap with a predicted ORF(ORF 001.ng) from N. gonorrhoeae:

m001/g001         10        20        30        40        50        60m001.pep MLPQGKAARRMSANEVCGXLXAWXVLVICQTLPKRDTLNGSGTHTVPVWAILPRSLRSKS||||||||||:||||| |   |  |||||||||||||||||||||:|||||||||||||| g001MLPQGKAARRVSANEVSGRACARMVLVICQTLPKRDTLNGSGTHTLPVWAILPRSLRSKS        10        20        30        40        50        60        70        80        90       100       110       120 m001.pepTIITFSARFFGSACNSAARRSSCPSPKIGAVPFIGSVLMVPSEPILRKSSGEKHSVHADC||||||||||||:|||||||||||||||||||||||||||||| :||||||||||||||| g001TIITFSARFFGSVCNSAARRSSCPSPKIGAVPFIGSVLMVPSEAMLRKSSGEKHSVHADC        70        80        90       100       110       120        130m001.pep PSASGRWDKTAX |::|||||:||| g001 PASSGRWDNTAX        130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 7>:

g003.seq 1 ATGGTCGTAT TCGTGGCTGA AGGCGTATTC GGTCGCGCTG TTTTGGGTCA 51CTTGGTATTG CTCTTCGGTC AGGGTGCGTT TGAGTTCGGC GTCACTCGGT 101 TTTTTATACGTTGCCGCGTC GAAGCCTTTG CCTTGCGGTG CGGCTTTGGT 151 TTTGCCCGGC AGCGGTTCGTCGGCTTTGCG GATGTCGATG TGGCAGTAGC 201 CGTTGGGGTT TTTAATCAGG TAGTCCTGATGGTATTCCTC GGCGTCGTAG 251 AAGTTTTTCA GCGGTTCGTT TTCAACAACG AGGGGCAGTTGGTATTTTTG 301 CTGCTCGCGT TTGAGGGCGG CGGCGATGAC GGCTTTTTCG GCGGGGTCGG351 TGTAGTACAC GCCGCTGCGG TATTGCGTGC CGGTGTCGTT ACCCTGTTTG 401TTGAGGCTGG TCGGATCAAC GACGCGGAAA TAATATTGCA GGATGTCGTC 451 CAGgCTGagtTTGTCGGCAT CGTaggtcac tTTGACGGTC TCGGCATGAC 501 CCGTATGGCG GTaggacacttctTCgtanc TcGGGtTTTC CGTGttGCCG 551 TTGGCgttac cGGATACCGC gtcaACCACGCCGTcgatgc gttggaAATa 601 ggCTTCCAAg ccccaaaagc agccgccggc gaagtaaatggtgcccgtgt 651 tcatgattGC TGaThis corresponds to the amino acid sequence <SEQ ID 8; ORF 003.ng>:

g003.pep 1 MVVFVAEGVF GRAVLGHLVL LFGQGAFEFG VTRFFIRCRV EAFALRCGFG 51FARQRFVGFA DVDVAVAVGV FNQVVLMVFL GVVEVFQRFV FNNEGQLVFL 101 LLAFEGGGDDGFFGGVGVVH AAAVLRAGVV TLFVEAGRIN DAEIILQDVV 151 QAEFVGIVGH FDGLGMTRMAVGHFFVRVFR VAVGVTGYRV NHAVDALEIG 201 FQAPKAAAGE VNGARVHDCThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 9>:

m003.seq 1 ATGGTCGTAT TCGTGGCTGA AGGCATATTC GGTCGCGCTG TTTTGGGTAA 51CTTGsTATTG CTCTTCGGTC AGGGTGCGTT TGAGTTCGGC GTCACTCGGT 101 TTTTTATACGTTGCCGCGTC GAAGCCTTTG CCTTGCGGGG CGGTCTTGGT 151 TTTGCCCGGC AGCGGTTCGTCAGCkTTGCG GATGTCGATG TGGCAGTAGC 201 CGTTGGGGTT TTTAATCAAG TAGTCCTGATGGTATTCCTC GGCATCGTAG 251 AAGTTTTtCA GCGGCTCGTT TTCAACAACG AGGGGCAGTTGGTATTTTTG 301 CTGCTCGCGT TTGAGGGCGk CGGCGATGAC GGCTTTTTCG kCGGGGTCGG351 TGTAGTACAC GCCGCTGCGG TATTGCGTAC CGGTGTCGTT GCCCTGTTTG 401TTGAGGCTGG TCGGATCAAC GACGCGGAAG AAATATTGCA GGATGTCGTC 451 TAGGCTGAGTTTGTCGGCAT CGTAGGTCAC TTTGACGGTT TCGGCGTGGC 501 CCGTATGGCG GTAGGACACGTCTTCATAGC TCGGATTTTT CGTGTTGCCG 551 TTGGCGTAGC CGGATACCGC GTCAACCACGCCGTCGATGC GTTGGAAATA 601 GGCTTCCAAG CCCCAGAAGC AGCg.CCGGC GAGGTAAATGGTGCGCGTGT 651 TCATGATTTT TGAThis corresponds to the amino acid sequence <SEQ ID 10; ORF 003>:

m003.pep Length: 221 1 MVVFVAEGIF GRAVLGNLXL LFGQGAFEFG VTRFFIRCRVEAFALRGGLG 51 FARQRFVSXA DVDVAVAVGV FNQVVLMVFL GIVEVFQRLV FNNEGQLVFL 101LLAFEGXGDD GFFXGVGVVH AAAVLRTGVV ALFVEAGRIN DAEEILQDVV 151 *AEFVGIVGHFDGFGVARMA VGHVFIARIF RVAVGVAGYR VNHAVDALEI 201 GFQAPEAAXG EVNGARVHDF *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 11>:

a003.seq 1 ATGGTCGTAT TCGTGGCTGA AGGCATATTC GGTCGCGCTG TTTTGGGTAA 51CTTGGTATTG CTCTTCGGTC AGGGTGCGTT TGAGTTCGGC GTCACTCGGT 101 TTTTTATACGTTGCCGCGTC GAAGCCTTTG CCTTGCGGTG CGGTCTTGGT 151 TTTGCCCGGC AGCGGTTCGTCGGCTTTGCG GATATCGATG TGGCAGTAGC 201 CGTTGGGGTT TTTAATCAAG TAGTCCTGATGGTATTCCTC GGCATCGTAG 251 AAGTTTTTCA GCGGCTCGTT TTCAACAACG AGGGGCAGTTGGTATTTTTG 301 CTGCTCGCGT TTGAGGGCGG CGGCGATGAC GGCTTTTTCG GCGGGGTCGG351 TGTAGTACAC GCCGCTGCGG TATTGCGTAC CGGTGTCGTT GCCCTGTTTG 401TTGAGGCTGG TCGGATCAAC GACGCGGAAG AAATATTGCA GGATGTCGTC 451 TAGGCTGAGTTTGTCGGCAT CGTAGGTCAC TTTGACGGTT TCGGCGTGGC 501 CCGTATGGCG GTAGGACACGTCTTCATAGC TCGGATTTTT CGTGTTGCCG 551 TTGGCGTAGC CGGATACCGC GTCAACCACGCCGTCGATGC GTTGGAAATA 601 GGCTTCCAAG CCCCAGAAGC AGCCGCCGGC GAGGTAGATGGTGCGCGTGT 651 TCATGATTTT TGAThis corresponds to the amino acid sequence <SEQ ID 12; ORF 003.a>:

a003.pep 1 MVVFVAEGIF GRAVLGNLVL LFGQGAFEFG VTRFFIRCRV EAFALRCGLG 51FARQRFVGFA DIDVAVAVGV FNQVVLMVFL GIVEVFQRLV FNNEGQLVFL 101 LLAFEGGGDDGFFGGVGVVH AAAVLRTGVV ALFVEAGRIN DAEEILQDVV 151 *AEFVGIVGH FDGFGVARMAVGHVFIARIF RVAVGVAGYR VNHAVDALEI 201 GFQAPEAAAG EVDGARVHDF * m003/a00395.9% identity over a 220 aa overlap        10        20        30        40        50        60 m003.pepMVVFVAEGIFGRAVLGNLXLLFGQGAFEFGVTRFFIRCRVEAFALRGGLGFARQRFVSXA|||||||||||||||||| ||||||||||||||||||||||||||| ||||||||||: | a003MVVFVAEGIFGRAVLGNLVLLFGQGAFEFGVTRFFIRCRVEAFALRCGLGFARQRFVGFA        10        20        30        40        50        60        70        80        90       100       110       120 m003.pepDVDVAVAVGVFNQVVLMVFLGIVEVFQRLVFNNEGQLVFLLLAFEGXGDDGFFXGVGVVH|:|||||||||||||||||||||||||||||||||||||||||||| |||||| |||||| a003DIDVAVAVGVFNQVVLMVFLGIVEVFQRLVFNNEGQLVFLLLAFEGGGDDGFFGGVGVVH        70        80        90       100       110       120       130       140       150       160       170       180 m003.pepAAAVLRTGVVALFVEAGRINDAEEILQDVVXAEFVGIVGHFDGFGVARMAVGHVFIARIF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a003AAAVLRTGVVALFVEAGRINDAEEILQDVVXAEFVGIVGHFDGFGVARMAVGHVFIARIF       130       140       150       160       170       180       190       200       210       220 m003.pepRVAVGVAGYRVNHAVDALEIGFQAPEAAXGEVNGARVHDFX|||||||||||||||||||||||||||| |||:|||||||| a003RVAVGVAGYRVNHAVDALEIGFQAPEAAAGEVDGARVHDFX       190       200       210       220Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 003 shows 88.6% identity over a 219 aa overlap with a predicted ORF(ORF 003.ng) from N. gonorrhoeae:

m003/g003          10        20        30        40        50        60m003.pep MVVFVAEGIFGRAVLGNLXLLFGQGAFEFGVTRFFIRCRVEAFALRGGLGFARQRFVSXA||||||||:|||||||:| ||||||||||||||||||||||||||| |:||||||||: | g003MVVFVAEGVFGRAVLGHLVLLFGQGAFEFGVTRFFIRCRVEAFALRCGFGFARQRFVGFA         10        20        30        40        50        60         70        80        90       100       110       120 m003.pepDVDVAVAVGVFNQVVLMVFLGIVEVFQRLVFNNEGQLVFLLLAFEGXGDDGFFXGVGVVH|||||||||||||||||||||:||||||:||||||||||||||||| |||||| |||||| g003DVDVAVAVGVFNQVVLMVFLGVVEVFQRFVFNNEGQLVFLLLAFEGGGDDGFFGGVGVVH         70        80        90       100       110       120        130       140       150       160       170       180 m003.pepAAAVLRTGVVALFVEAGRINDAEEILQDVVXAEFVGIVGHFDGFGVARMAVGHVFIARIF||||||:|||:|||||||||||| |||||| ||||||||||||:|::|||||| |: |:| g003AAAVLRAGVVILFVEAGRINDAEIILQDVVQAEFVGIVGHFDGLGMTRMAVGHFFV-RVF        130       140       150       160       170       180        190       200       210       220 m003.pepRVAVGVAGYRVNHAVDALEIGFQAPEAAXGEVNGARVHDFX||||||:||||||||||||||||||:|| |||||||||| g003RVAVGVTGYRVNHAVDALEIGFQAPKAAAGEVNGARVHDC         190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 13>:

g004.seq 1 ATGgtagAAC GGCATATCCA GCATTTGCGG AACGGTCATC TTCATTTGAT 51GCGCCCATGC CAACAagtga gccaAAtgtT CGGCGGCAGG GCCTacgatT 101 TCCGCGCCGATAAagcggcc gGTGgctTTT tcgGCataca ggcgcaTatg 151 gCCTTTGTTT ACCAgcatcacgcggctgcg accttgaTTT TTGAACGATA 201 CTTCGCCgaT GACAAATTCG TCGGCTTGGTATTGCGCGGC AACCTGCGCG 251 TATTTCAAAC CGACAAAGCC GATTTGCgga ctggtaaACACCACGCCAAT 301 GGTgctgcgg cGCAAACCGC TGCCGATATt cgGgtagcgg ccccgcgtta351 ttgcccggca atcttacctt ggtcggcggc ttcatGCAGC AGGGGCagtt 401ggttggacgc gtcgcccgca ataAAGATAT GCGGAATgct ggtCTGCATg 451 gtCAGCGGATCGGCAACGGG tacgccgcgc gcgtctttgT CGATATTGAT 501 GTTTTCCAAA CCGATATtgTCAACGTTCGG ACGGCgACCT ACGGCTGCCA 551 ACATATATTC GGCAACAAAT ACGCCTTTTTCGCCATCCTG CTCCCAATGG 601 ACTtctACAT TGCCGTCTGC GTCGAGTTTG ACCTCGGTTTTAGCATCCAG 651 ATGCAGTTTC AATtctTCTC CGAACACGGC TTTCGCCTCG TCTGAAACAA701 CGGGGTCGGA AATGCCGCCG ATGATTCCGC CCAAACCGAA AATTTCAACT 751TTCACACCCA AACGGTGCAA TGCCTGAThis corresponds to the amino acid sequence <SEQ ID 14; ORF 004.ng>:

g004.pep 1 MVERHIQHLR NGHLHLMRPC QQVSQMFGGR AYDFRADKAA GGFFGIQAHM 51AFVYQHHAAA TLIFERYFAD DKFVGLVLRG NLRVFQTDKA DLRTGKHHAN 101 GAAAQTAADIRVAAPRYCPA ILPWSAASCS RGSWLDASPA IKICGMLVCM 151 VSGSATGTPR ASLSILMFSKPILSTFGRRP TAANIYSATN TPFSPSCSQW 201 TSTLPSASSL TSVLASRCSF NSSPNTAFASSETTGSEMPP MIPPKPKIST 251 FTPKRCNA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 15>:

m004.seq 1 ATGGTAGAAC GGCATATCCA GCATTTGCGG AACGGTCATC TTCATTTGAT 51GTGCCCAAGC CAACAGGTGC GCCAAATGTT CGGCGGCAGG GCCTACGATT 101 TCCGCGCCGATAAAGCGGCC GGTGGCTTTT TCGGCATACA GGCGCATATG 151 GCCTTTGTTC ACCAGCATCACGCGGCTGCG GCCTTGGTTT TTGAACGATA 201 CTTCGCCGAT GACAAATTCG TCGGCTTGGTATTGCGCGGC AACCTGCGCG 251 TATTTCAGAC CGACAAAGCC GATTTGCGGA CTGGTAAACACCACGCCGAT 301 GGTGCTGCGC CGCAAACCGC CGCCGATATT CGGGTAGCGG CCGCGTTATC351 GCCGGCAATC TTGCCTTGGT CGGCAGCTTC ATGCAGCAGA GGCAGTTGGT 401TGGACGCATC GCCTGCGATG AAGATATGCG GAATACTGGT CTGCATGGTC 451 AGCGGGTCGGCAACAGGTAC GCCGCGCGCA TCTTTTTCGA TATTGATATT 501 TTCCAAACCG ATATTGTCAACGTTCGGACG GCGGCCCACG GCTGCCAGCA 551 TATATTCGGC AACAAATACG CCTTTTTCGCCATCCTGCTC CCAATGGACT 601 TCTACATTGC CGTCTGCATC GAGTTTGACC TCGGTTTTAGCATCCAGATG 651 CAGTTTCAAT TCTTCGCCGA ACACGGCGTT CGCCTCGTCT GAAACGACGG701 GGTCGGAAAT GCCGCCGATG ATTCCGCCCA AACCGAAAAT TTCAACTTTC 751ACGCCCAAAC GGTGCAATGC CTGAThis corresponds to the amino acid sequence <SEQ ID 16; ORF 004>:

m004.pep 1 MVERHIQHLR NGHLHLMCPS QQVRQMFGGR AYDFRADKAA GGFFGIQAHM 51AFVHQHHAAA ALVFERYFAD DKFVGLVLRG NLRVFQTDKA DLRTGKHHAD 101 GAAPQTAADIRVAAALSPAI LPWSAASCSR GSWLDASPAM KICGILVCMV 151 SGSATGTPRA SFSILIFSKPILSTFGRRPT AASIYSATNT PFSPSCSQWT 201 STLPSASSLT SVLASRCSFN SSPNTAFASSETTGSEMPPM IPPKPKISTF 251 TPKRCNA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 17>:

a004.seq 1 ATGGTAGAAC GGCATATCCA GCATTTGCGG AACGGTCATC TTCATTTGAT 51GTGCCCAAGC CAACAGGTGC GCCAAATGTT CGGCGGCCGG ACCTACGATT 101 TCTGCGCCGATGAAGCGGCC GGTGGCTTTT TCGGCATACA GGCGCATATG 151 GCCTTTGTTT ACCAGCATCACGCGGCTGCG GCCTTGGTTT TTGAACGATA 201 CTTCGCCGAT GACAAATTCG TCGGCTTGGTATTGCGCGGC AACCTGCGCG 251 TATTTCAAAC CGACAAAGCC GATTTGCGGA CTGGTGAACACTACGCCGAT 301 GGTGCTGCGG CGCAAACCGC CGCCGATATT CGGGTAGCGG CCGCGTTATC351 GCCGGCAATC TTGCCTTGGT CGGCGGCTTC ATGCAGCAGG GGCAGTTGGT 401TGGACGCGTC GCCCGCAATA AAGATATGCG GAATACTGGT CTGCATAGTC 451 AGCGGATCGGCAACGGGTAC GCCGCGCGCA TCTTTTTCGA TATTGATGTT 501 TTCCAAACCG ATATTGTCAACGTTCGGACG GCGGCCTACG GCTGCCAGCA 551 TATATTCGGC AACAAATACG CCTTTTTCGCCATCCTGCTC CCAATGGACT 601 TCTACATTGC CGTCTGCGTC GAGTTTGGCC TCGGTTTTAGCATCCAAATG 651 CAGTTTCAAT TCTTCACCGA ACACGGCTTT CGCCTCGTCT GAAACGACGG701 GGTCGGAAAT GCCGCCGATG ATGCCACCCA AACCGAAAAT TTCAACTTTC 751ACGCCCAAAC GGTGCAATGC CTGAThis corresponds to the amino acid sequence <SEQ ID 18; ORF 004.a>:

a004.pep 1 MVERHIQHLR NGHLHLMCPS QQVRQMFGGR TYDFCADEAA GGFFGIQAHM 51AFVYQHHAAA ALVFERYFAD DKFVGLVLRG NLRVFQTDKA DLRTGEHYAD 101 GAAAQTAADIRVAAALSPAI LPWSAASCSR GSWLDASPAI KICGILVCIV 151 SGSATGTPRA SFSILMFSKPILSTFGRRPT AASIYSATNT PFSPSCSQWT 201 STLPSASSLA SVLASKCSFN SSPNTAFASSETTGSEMPPM MPPKPKISTF 251 TPKRCNA* m004/a004 94.9% identity over a 257aa overlap         10        20        30        40        50        60m004.pep MVERHIQHLRNGHLHLMCPSQQVRQMFGGRAYDFRADKAAGGFFGIQAHMAFVHQHHAAA||||||||||||||||||||||||||||||:||| ||:|||||||||||||||:|||||| a004MVERHIQHLRNGHLHLMCPSQQVRQMFGGRTYDFCADEAAGGFFGIQAHMAFVYQHHAAA        10        20        30        40        50        60        70        80        90       100       110       120 m004.pepALVFERYFADDKFVGLVLRGNLRVFQTDKADLRTGKHHADGAAPQTAADIRVAAALSPAI|||||||||||||||||||||||||||||||||||:|:||||| |||||||||||||||| a004ALVFERYFADDKFVGLVLRGNLRVFQTDKADLRTGEHYADGAAAQTAADIRVAAALSPAI        70        80        90       100       110       120       130       140       150       160       170       180 m004.pepLPWSAASCSRGSWLDASPAMKICGILVCMVSGSATGTPRASFSILIFSKPILSTFGRRPT|||||||||||||||||||:||||||||:||||||||||||||||:|||||||||||||| a004LPWSAASCSRGSWLDASPAIKICGILVCIVSGSATGTPRASFSILMFSKPILSTFGRRPT       130       140       150       160       170       180       190       200       210       220       230       240 m004.pepAASIYSATNTPFSPSCSQWTSTLPSASSLTSVLASRCSFNSSPNTAFASSETTGSEMPPM|||||||||||||||||||||||||||||:|||||:|||||||||||||||||||||||| a004AASIYSATNTPFSPSCSQWTSTLPSASSLASVLASKCSFNSSPNTAFASSETTGSEMPPM       190       200       210       220       230       240        250m004.pep IPPKPKISTFTPKRCNAX :||||||||||||||||| a004 MPPKPKISTFTPKRCNAX       250Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 004 shows 93.4% identity over a 258 aa overlap with a predicted ORF(ORF 004.ng) from N. gonorrhoeae:

m004/g004           10        20        30        40        50        60m004.pep   MVERHIQHLRNGHLHLMCPSQQVRQMFGGRAYDFRADKAAGGFFGIQAHMAFVHQHHAAA  ||||||||||||||||| | ||| |||||||||||||||||||||||||||||:|||||| g004  MVERHIQHLRNGHLHLMRPCQQVSQMFGGRAYDFRADKAAGGFFGIQAHMAFVYQHHAAA          10        20        30        40        50        60          70        80        90       100       110       119 m004.pep  ALVFERYFADDKFVGLVLRGNLRVFQTDKADLRTGKHHADGAAPQTAADIRVAAA-LSPA  :|:||||||||||||||||||||||||||||||||||||:||| ||||||||||    || g004  TLIFERYFADDKFVGLVLRGNLRVFQTDKADLRTGKHHANGAAAQTAADIRVAAPRYCPA          70        80        90       100       110       120120       130       140       150       160       170      179 m004.pep  ILPWSAASCSRGSWLDASPAMKICGILVCMVSGSATGTPRASFSILIFSKPILSTFGRRP  ||||||||||||||||||||:||||:||||||||||||||||:|||:||||||||||||| g004  ILPWSAASCSRGSWLDASPAIKICGMLVCMVSGSATGTPRASLSILMFSKPILSTFGRRP         130       140       150       160       170       180180       190       200       210       220       230      239 m004.pep  TAASIYSATNTPFSPSCSQWTSTLPSASSLTSVLASRCSFNSSPNTAFASSETTGSEMPP  |||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||| g004  TAANIYSATNTPFSPSCSQWTSTLPSASSLTSVLASRCSFNSSPNTAFASSETTGSEMPP         190       200       210       220       230       240240       250 m004.pep   MIPPKPKISTFTPKRCNAX   |||||||||||||||||| g004  MIPPKPKISTFTPKRCNA          250The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 19>:

g005.seq 1 ATGGGGATGG ACAATATTGA TATGTTCATG CCTGAACAAG AGGAAATCCA 51ATCAATGTGG AAAGAAATTT TACTGAATTA CGGTATTTTC CTGCTCGAAC 101 TGCTTACCGTGTTCGGCGCA ATTGCGCTGA TTGTGTTGGC TATCGTACAG 151 AGTAAGAAAC AGTCGGAAAGCGGCAGTGTC GTACTGACAG ATTTTTCGGA 201 AAATTATAAA AAACAGCGGC AATCGTTTGAAACATTCTTT TTAAGCGAGG 251 AAGAGACAAA ACATCAGGAA AAAAAAGAAA AGAAAAAGGAAAAGGCGGAA 301 GCCAAAGCAG AGAAAAAGCG TTTGAAGGAG GGCGGGGAGA AATCTGCCGA351 AACGCAAAAA TCCCGCCTTT TTGTGTTGGA TTTTGACGGC GATTTGTATG 401CACACGCCGT AGAATCCTTG CGTCATGAGA TTACGGCGGT GCTTTTGATT 451 GCCAAGCCTGAAGATGAGGT TCTGCTCAGA TTGGAAAGTC CGGGCGGCGT 501 GGTTCACGGT TACGGTTTGGCGGCTTCGCA GCTTAGGCGT TTGCGCGAAC 551 GCAATATTCC GCTGAccgtc gccgTCGATAAGGTCGCGGC AAGCGgcggc 601 tatatgatgg cgtgtgtgGC GGATAAAATT GTTTCCGCtccgtttgcggt 651 catcggttcg gtgggtgtgg tgGcggaagt gcCGAATATC CAccgCctGT701 TGAAAAAACA TGATATTGAT GTGGATGTGA TGACGGCGGG CGAATTTAAG 751CGCACGGTTA CTTTTATGGG TGAAAATACG GAAAAGGGCA AACAGAAATT 801 CCGGCAGGAACTGGAGGAAA CGCATCAGTT GTTCAAGCAG TTTGTCAGTG 851 AAAACCGCCC CGGGTTGGATATTGAAAAAA TAGCGACGGG CGAGCATTGG 901 TTCGGCCGGC AGGCGTTGGC GTTGAACTTGATTGACGAGA TTTCGACCAG 951 TGATGATTTG TTGTTGAAAG CGTTTGAAAA CAAACAGGttaTCGAAGTGA 1001 AATATCAGGA GAAGCGAAGC CTGATCCAGC GCATTGGTTT GCAGGCGGAA1051 GCTTCCGTTG AAAAGTTGTT TGCCAAACTT GTCAACCGGC GAGCGGATGT 1101 GATGTAGThis corresponds to the amino acid sequence <SEQ ID 20; ORF 005.ng>:

g005.pep 1 MGMDNIDMFM PEQEEIQSMW KEILLNYGIF LLELLTVFGA IALIVLAIVQ 51SKKQSESGSV VLTDFSENYK KQRQSFETFF LSEEETKHQE KKEKKKEKAE 101 AKAEKKRLKEGGEKSAETQK SRLFVLDFDG DLYAHAVESL RHEITAVLLI 151 AKPEDEVLLR LESPGGVVHGYGLAASQLRR LRERNIPLTV AVDKVAASGG 201 YMMACVADKI VSAPFAVIGS VGVVAEVPNIHRLLKKHDID VDVMTAGEFK 251 RTVTFMGENT EKGKQKFRQE LEETHQLFKQ FVSENRPGLDIEKIATGEHW 301 FGRQALALNL IDEISTSDDL LLKAFENKQV IEVKYQEKRS LIQRIGLQAE351 ASVEKLFAKL VNRRADVM*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 21>:

m005.seq 1 ATGGACAATA TTGACATGTT CATGCCTGAA CAAGAGGAAA TCCAATCAAT 51GTGGAAAGAA ATTTTACTGA ATTACGGTAT TTTCCTGCTC GAACTGCTTA 101 CCGTGTTCGGCGCAATTGCG CTGATTGTGT TGGCTATCGT ACAGAGTAAG 151 AAACAGTCGG AwAGCGGCAGTGTCGTACTG ACGGATTTTT CGGAAAATTA 201 TAAAAAACAG CGGCAATCGT TTGAAGCATTCTTTTTAAGC GGGGAAGAGG 251 CACAACATCA GGAAAAAGAG GAAAAGAAAA AGGAAAAGGCGGAAGCCAAA 301 GCAGAGAAAA A.CGTTTGAA GGAGGGTGGG GAGAAATCTG CCGAAACGCA351 nAAATCACGC CTTTTTGTGT TGGANNNNNN NNNNNNNNNN NNNNNNNNNN 401NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 451 NNNNNNNNNNNNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 501 NNNNNNNNNN NNNNNNNNNNNNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 551 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNNNNGCGAGCGG CGGTTATATG 601 ATGGCGTGTG TGGCGGATAA AATTGCTTCC GCTCCGTTTGCGATTGTCGG 651 TTCGGTGGGT GTGGTGGCGG AAGTACCGAA TATCCACCGC CTGTTGAAAA701 AACATGATAT TGATGTGGAT GTGATGACGG CGGGCGAATT TAAGCGCACG 751GTTACTTTTA TGGGTGAAAA TACGGAAAAG GGCAAACAGA AATTCCGACA 801 GGAACTGGAGGAAACGCATC AGTTGTTCAA GCAGTTTGTC AGCGAGAACC 851 GCCCTCAATT GGATATTGAGGAAGTGGCAA CGGGCGAGCA TTGGTTCGGT 901 CGGCAGGCGT TGGCGTTGAA CTTGATTGACGAGATTTCGA CCAGTGATGA 951 TTTGTTGTTG AAAGCGTTTG AAAACAAACA GGTTATCGAAGTGAAATATC 1001 AGGAGAAGCA AAGCCTGATC CAGCGCATTG GTTTGCAGGC GGAAGCTTCT1051 GTTGAAAAGT TGTTTGCCAA ACTTGTCAAC CGGCGGGCGG ATGTGATGTA 1101 GThis corresponds to the amino acid sequence <SEQ ID 22; ORF 005>:

m005.pep 1 MDNIDMFMPE QEEIQSMWKE ILLNYGIFLL ELLTVFGAIA LIVLAIVQSK 51KQSXSGSVVL TDFSENYKKQ RQSFEAFFLS GEEAQHQEKE EKKKEKAEAK 101 AEKXRLKEGGEKSAETXKSR LFVLXXXXXX XXXXXXXXXX XXXXXXXXXX 151 XXXXXXXXXX XXXXXXXXXXXXXXXXXXXX XXXXXXXXXX XXXXASGGYM 201 MACVADKIAS APFAIVGSVG VVAEVPNIHRLLKKHDIDVD VMTAGEFKRT 251 VTFMGENTEK GKQKFRQELE ETHQLFKQFV SENRPQLDIEEVATGEHWFG 301 RQALALNLID EISTSDDLLL KAFENKQVIE VKYQEKQSLI QRIGLQAEAS351 VEKLFAKLVN RRADVM*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 23>:

a005.seq 1 ATGGACAATA TTGACATGTT CATGCCTGAA CAAGAGGAAA TCCAATCAAT 51GTGGAAAGAA ATTTTACTGA ATTACGGTAT TTTCCTGCTC GAACTGCTTA 101 CCGTGTTCGGCGCAATTGCG CTGATTGTGT TGGCTATCGT ACAGAGTAAG 151 AAACAGTCGG AAAGCGGCAGTGTCGTACTG ACGGATTTTT CGGAAAATTA 201 TAAAAAACAG CGGCAATCGT TTGAAGCATTCTTTTTAAGC GGGGAAGAGG 251 CAAAACATCA GGAAAAAGAG GAAAAGAAAA AGGAAAAGGCGGAAGCCAAA 301 GCAGAGAAAA AGCGTTTGAA GGAGGGTGGG GAGAAATCTT CCGAAACGCA351 AAAATCCCGC CTTTTTGTGT TGGATTTTGA CGGCGATTTG TATGCACACG 401CCGTAGAATC CTTGCGTCAT GAGATTACGG CGGTGCTTTT GATTGCCAAG 451 CCTGAAGATGAGGTTCTGCT TAGATTGGAA AGTCCGGGCG GCGTGGTTCA 501 CGGTTACGGT TTGGCGGCTTCGCAGCTTAG GCGTTTGCGC GAACGCAATA 551 TTCCGCTGAC CGTCGCCGTC GATAAGGTGGCGGCGAGCGG TGGTTATATG 601 ATGGCGTGTG TGGCGGATAA AATTGTTTCC GCTCCGTTTGCGATTGTCGG 651 TTCGGTGGGT GTTGTAGCGG AAGTACCGAA TATCCACCGC CTGTTGAAAA701 AACATGATAT TGATGTGGAT GTGATGACGG CGGGCGAATT TAAGCGCACG 751GTTACTTTTA TGGGTGAAAA TACGGAAAAG GGCAAACAGA AATTCCGACA 801 GGAACTGGAGGAAACGCATC AGTTGTTCAA GCAGTTTGTC AGCGAGAACC 851 GCCCTCAATT GGATATTGAGGAAGTGGCAA CGGGCGAGCA TTGGTTCGGT 901 CGGCAGGCGT TGGCGTTGAA CTTGATTGACGAGATTTCGA CCAGTGATGA 951 TTTGTTGTTG AAAGCGTTTG AAAACAAACA GGTTATCGAAGTGAAATATC 1001 AGGAGAAGCA AAGCCTGATC CAGCGCATTG GTTTGCAGGC GGAAGCTTCT1051 GTTGAAAAGT TGTTTGCCAA ACTTGTCAAC CGGCGGGCGG ATGTGATGTA 1101 GThis corresponds to the amino acid sequence <SEQ ID 24; ORF 005.a>:

a005.pep 1 MDNIDMFMPE QEEIQSMWKE ILLNYGIFLL ELLTVFGAIA LIVLAIVQSK 51KQSESGSVVL TDFSENYKKQ RQSFEAFFLS GEEAKHQEKE EKKKEKAEAK 101 AEKKRLKEGGEKSSETQKSR LFVLDFDGDL YAHAVESLRH EITAVLLIAK 151 PEDEVLLRLE SPGGVVHGYGLAASQLRRLR ERNIPLTVAV DKVAASGGYM 201 MACVADKIVS APFAIVGSVG VVAEVPNIHRLLKKHDIDVD VMTAGEFKRT 251 VTFMGENTEK GKQKFRQELE ETHQLFKQFV SENRPQLDIEEVATGEHWFG 301 RQALALNLID EISTSDDLLL KAFENKQVIE VKYQEKQSLI QRIGLQAEAS351 VEKLFAKLVN RRADVM* m005/a005 79.2% identity over a 366 aa overlap        10        20        30        40        50        60 m005.pepMDNIDMFMPEQEEIQSMWKEILLNYGIFLLELLTVFGAIALIVLAIVQSKKQSXSGSVVL||||||||||||||||||||||||||||||||||||||||||||||||||||| |||||| a005MDNIDMFMPEQEEIQSMWKEILLNYGIFLLELLTVFGAIALIVLAIVQSKKQSESGSVVL        10        20        30        40        50        60        70        80        90       100       110       120 m005.pepTDFSENYKKQRQSFEAFFLSGEEAQHQEKEEKKKEKAEAKAEKXRLKEGGEKSAETXKSR||||||||||||||||||||||||:|||||||||||||||||| |||||||||:|| ||| a005TDFSENYKKQRQSFEAFFLSGEEAKHQEKEEKKKEKAEAKAEKKRLKEGGEKSSETQKSR        70        80        90       100       110       120       130       140       150       160       170       180 m005.pepLFVLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX||||                  : a005LFVLDFDGDLYAHAVESLRHEITAVLLIAKPEDEVLLRLESPGGVVHGYGLAASQLRRLR       130       140       150       160       170       180       190       200       210       220       230       240 m005.pepXXXXXXXXXXXXXXASGGYMMACVADKIASAPFAIVGSVGVVAEVPNIHRLLKKHDIDVD      :       ||||||||||||||:||||||||||||||||||||||||||||||| a005ERNIPLTVAVDKVAASGGYMMACVADKIVSAPFAIVGSVGVVAEVPNIHRLLKKHDIDVD       190       200       210       220       230       240       250       260       270       280       290       300 m005.pepVMTAGEFKRTVTFMGENTEKGKQKFRQELEETHQLFKQFVSENRPQLDIEEVATGEHWFG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a005VMTAGEFKRTVTFMGENTEKGKQKFRQELEETHQLFKQFVSENRPQLDIEEVATGEHWFG       250       260       270       280       290       300       310       320       330       340       350       360 m005.pepRQALALNLIDEISTSDDLLLKAFENKQVIEVKYQEKQSLIQRIGLQAEASVEKLFAKLVN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a005RQALALNLIDEISTSDDLLLKAFENKQVIEVKYQEKQSLIQRIGLQAEASVEKLFAKLVN       310       320       330       340       350       360 m005.pepRRADVMX ||||||| a005 RRADVMXComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 005 shows 77.0% identity over a 366 aa overlap with a predicted ORF(ORF 005.ng) from N. gonorrhoeae:

m005/g005            10        20        30        40        50 m005.pep   MDNIDMFMPEQEEIQSMWKEILLNYGIFLLELLTVFGAIALIVLAIVQSKKQSXSGSV   ||||||||||||||||||||||||||||||||||||||||||||||||||||| |||| g005 MGMDNIDMFMPEQEEIQSMWKEILLNYGIFLLELLTVFGAIALIVLAIVQSKKQSESGSV         10        20        30        40        50        60 60        70        80        90       100       110 m005.pep VLTDFSENYKKQRQSFEAFFLSGEEAQHQEKEEKKKEKAEAKAEKKRLKEGGEKSAETXK |||||||||||||||||:|||| ||::||||:|||||||||||||||||||||||||| | g005 VLTDFSENYKKQRQSFETFFLSEEETKHQEKKEKKKEKAEAKAEKKRLKEGGEKSAETQK         70        80        90       100       110       120120       130       140       150       160       170 m005.pep SRLFVLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX ||||||                  : g005 SRLFVLDFDGDLYAHAVESLRHEITAVLLIAKPEDEVLLRLESPGGVVHGYGLAASQLRR        130       140       150       160       170       180180       190       200       210       220       230 m005.pep XXXXXXXXXXXXXXXXASGGYMMACVADKIASAPFAIVGSVGVVAEVPNIHRLLKKHDID         :       ||||||||||||||:|||||::|||||||||||||||||||||| g005 LRERNIPLTVAVDKVAASGGYMMACVADKIVSAPFAVIGSVGVVAEVPNIHRLLKKHDID        190       200       210       220       230       240240       250       260       270       280       290 m005.pep VDVMTAGEFKRTVTFMGENTEKGKQKFRQELEETHQLFKQFVSENRPQLDIEEVATGEHW ||||||||||||||||||||||||||||||||||||||||||||||| ||||::|||||| g005 VDVMTAGEFKRTVTFMGENTEKGKQKFRQELEETHQLFKQFVSENRPGLDIEKIATGEHW        250       260       270       280       290       300300       310       320       330       340       350 m005.pep FGRQALALNLIDEISTSDDLLLKAFENKQVIEVKYQEKQSLIQRIGLQAEASVEKLFAKL ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||| g005 FGRQALALNLIDEISTSDDLLLKAFENKQVIEVKYQEKRSLIQRIGLQAEASVEKLFAKL        310       320       330       340       350       360 360m005.pep  VNRRADVMX  ||||||||| g005  VNRRADVMXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 25>:

g006.seq 1 ATGCTGCTGG TGCTggaatt ttggttCGGc gtGtCGGCGG TGGGCatact 51tgCGTTGTTT TTATGGCttt TGCCACGTTT TGCCGCCATC AGCGAAAACC 101 TGTATTTCCGCCTGAACAAC AGCTTGGAAC gcgACAACCA CTTTATCCGA 151 AAAGGCGACG AGCGGCAGCTGTACCGCCAT TACGGACTGG TTTCGCGCCT 201 GCGTGTGCTG ATTTCCAACC GCGAAGCCTTCGGCTATCTC TGCGTCGGCG 251 CGGCGATGGG TATTTTGTTC GGCTTTGCTT TTGTGATGATGACGCTCAAA 301 GGCTACGGCA GCGCGGGGCA TATTTATTCG GTCGGCACTT ATCTGTGGAT351 GTTTGCCATG AGTTTGGACG ATGTGCCGCG ATTGGTCGAA CAATATTCCA 401ATTTGAAAGA CATCGGACAA CGGATAGAGT GGTCGGAACG GAACATCAAA 451 GCCGGAACTT GAThis corresponds to the amino acid sequence <SEQ ID 26. ORF 006.ng>.

g006.pep 1 MLLVLEFWFG VSAVGILALF LWLLPRFAAI SENLYFRLNN SLERDNHFIR 51KGDERQLYRH YGLVSRLRVL ISNREAFGYL CVGAAMGILF GFAFVMMTLK 101 GYGSAGHIYSVGTYLWMFAM SLDDVPRLVE QYSNLKDIGQ RIEWSERNIK 151 AGT*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 27>:

m006.seq 1 ATGCTGCTGG TGCTGGAATT TTGGGTCGGC GTGTCGGCGG TGGGCATACT 51TGCGTTGTTT TTATGGCTTT TGCCACGTTT TGCCGCCATC AGCGAAAACC 101 TGTATTTCCGCCTGAACAAC AGCTTGGAAC GCGACAACCA CTTTATCCGA 151 AAAGGCGACC GGCGGCAGCTGTACCGCCAT TACGGACTGC TTGCGCGCCT 201 GCGTGTGCTG ATTTCCAACC GCGAAGCCTTCGGCTATCTC TGCGTCGGCA 251 CGGCGATGGG TATTTTGTTC GGCTTTGCTT TTGTGATGATGACGCTCAAA 301 GGCTACAGCA GCGCGGGGCA TGTCTATTCG GTCGGCACTT ATCTGTGGAT351 GTTTGCCATG AGTTTGGACG ACGTGCCGCG ATTGGTCGAA CAATATTCCA 401ATTTGAAAGA CATCGGACAA CGGATAGAGT GGTCGGAACG GAACATCAAA 451 GCCGGAACTTGAThis corresponds to the amino acid sequence <SEQ ID 28; ORF 006>:

m006.pep 1 MLLVLEFWVG VSAVGILALF LWLLPRFAAI SENLYFRLNN SLERDNHFIR 51KGDRRQLYRH YGLLARLRVL ISNREAFGYL CVGTAMGILF GFAFVMMTLK 101 GYSSAGHVYSVGTYLWMFAM SLDDVPRLVE QYSNLKDIGQ RIEWSERNIK 151 AGT*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 29>:

a006.seq 1 ATGCTGCTGG TGCTGGAATT TTGGGTCGGC GTGTCGGCGG TGGGCATACT 51TGCGTTGTTT TTATGGCTTT TGCCACGTTT TGCCGCCATC AGCGAAAACC 101 TGTATTTCCGCCTGAAGAAC AGCTTGGAAC GCGACAACCA CTTTATCCGA 151 AAAGGCGACG AGCGGCAGCTGGACCGCCAT TACGGACTGC TTGCGCGCCT 201 GCGTGTGCTG ATTTCCAACC GCGAAGCCTTCGGCTATCTC TGCGTCGGCA 251 CGGCGATGGG TATTTTGTTC GGCTTTGCTT TTGTGATGATGACGCTCAAA 301 GGCTACAGCA GCGCGGGGCA TGTCTATTCG GTCGGCACTT ATCTGTGGAT351 GTTTGCCATA AGTTTGGACG ACGTGCCGCG ATTGGTCGAA CAATATTCCA 401ATTTGAAAGA CATCGGACAA CGGATAGAGT GGTCGAAACG GAACATCAAA 451 GCCGGAACTT GAThis corresponds to the amino acid sequence <SEQ ID 30; ORF 006.a>:

a006.pep 1 MLLVLEFWVG VSAVGILALF LWLLPRFAAI SENLYFRLKN SLERDNHFIR 51KGDERQLDRH YGLLARLRVL ISNREAFGYL CVGTAMGILF GFAFVMMTLK 101 GYSSAGHVYSVGTYLWMFAI SLDDVPRLVE QYSNLKDIGQ RIEWSKRNIK 151 AGT* m006/a006 96.7%identity over a 153 aa overlap        10        20        30        40        50        60 m006.pepMLLVLEFWVGVSAVGILALFLWLLPRFAAISENLYFRLNNSLERDNHFIRKGDRRQLYRH||||||||||||||||||||||||||||||||||||||:||||||||||||||:||| || a006MLLVLEFWVGVSAVGILALFLWLLPRFAAISENLYFRLKNSLERDNHFIRKGDERQLDRH        10        20        30        40        50        60        70        80        90       100       110       120 m006.pepYGLLARLRVLISNREAFGYLCVGTAMGILFGFAFVMMTLKGYSSAGHVYSVGTYLWMFAM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: a006YGLLARLRVLISNREAFGYLCVGTAMGILFGFAFVMMTLKGYSSAGHVYSVGTYLWMFAI        70        80        90       100       110       120       130       140       150 m006.pepSLDDVPRLVEQYSNLKDIGQRIEWSERNIKAGTX |||||||||||||||||||||||||:||||||||a006 SLDDVPRLVEQYSNLKDIGQRIEWSKRNIKAGTX        130       140       150Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 006 shows 95.4% identity over a 153 aa overlap with a predicted ORF(ORF 006.ng) from N. gonorrhoeae:

m006/g006         10        20        30        40        50        60m006.pep MLLVLEFWVGVSAVGILALFLWLLPRFAAISENLYFRLNNSLERDNHFIRKGDRRQLYRH|||||||| ||||||||||||||||||||||||||||||||||||||||||||:|||||| g006MLLVLEFWFGVSAVGILALFLWLLPRFAAISENLYFRLNNSLERDNHFIRKGDERQLYRH        10        20        30        40        50        60        70        80        90       100       110       120 m006.pepYGLLARLRVLISNREAFGYLCVGTAMGILFGFAFVMMTLKGYSSAGHVYSVGTYLWMFAM|||::||||||||||||||||||:||||||||||||||||||:||||:|||||||||||| g006YGLVSRLRVLISNREAFGYLCVGAAMGILFGFAFVMMTLKGYGSAGHIYSVGTYLWMFAM        70        80        90       100       110       120       130       140       150 m006.pepSLDDVPRLVEQYSNLKDIGQRIEWSERNIKAGTX |||||||||||||||||||||||||||||||||g118 SLDDVPRLVEQYSNLKDIGQRIEWSERNIKAGT        130       140       150The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 31>:

g006-1.seq 1 ATGTGGAAAA TGTTGAAACA CATAGCCAAA ACCCACCGCA AGCGATTGAT 51TGGCACATTT TCCCCGGTCG GACTGGAAAA CCTTTTGATG CTGGGGTATC 101 CGGTGTTTGGCGGCTGGGCG ATTAATGCCG TGATTGCGGG GAGGGTGTGG 151 CAGGCGTTGC TGTACGCTTTGGTTGTATTT TTGATGTGGC TGGTCGGTGC 201 GGCACGGCGG ATTGCCGATA CGCGCACGTTTACGCGGATT TATACCGAAA 251 TCGCCGTGCC GGTTGTGTTG GAACAACGGC AGCGGCAAGTCCCGCATTCA 301 GCGGTAACTG CACGGGTTGC CCTGTCGCGT GAATTTGTCA GCTTTTTTGA351 AGAACACCTG CCGATTGCCG CGACATCCGT CGTATCCATA TTCGGCGCGT 401GCATCATGCT GCTGGTGCTG GAATTTTGGG TCGGCGTGTC GGCGGTGGGC 451 ATACTTGCGTTGTTTTTATG GCTTTTGCCA CGTTTTGCCG CCATCAGCGA 501 AAACCTGTAT TTCCGCCTGAACAACAGCTT GGAACGCGAC AACCACTTTA 551 TCCGAAAAGG CGACGAGCGG CAGCTGTACCGCCATTACGG ACTGGTTTCG 601 CGCCTGCGTG TGCTGATTTC CAACCGCGAA GCCTTCGGCTATCTCTGCGT 651 CGGCGCGGCG ATGGGTATTT TGTTCGGCTT TGCTTTTGTG ATGATGACGC701 TCAAAGGCTA CGGCAGCGCG GGGCATATTT ATTCGGTCGG CACTTATCTG 751TGGATGTTTG CCATGAGTTT GGACGATGTG CCGCGATTGG TCGAACAATA 801 TTCCAATTTGAAAGACATCG GACAACGGAT AGAGTGGTCG GAACGGAACA 851 TCAAAGCCGG AACTTGAThis corresponds to the amino acid sequence <SEQ ID 32; ORF 006-1.ng>:

g006-1.pep 1 MWKMLKHIAK THRKRLIGTF SPVGLENLLM LGYPVFGGWA INAVIAGRVW 51QALLYALVVF LMWLVGAARR IADTRTFTRI YTEIAVPVVL EQRQRQVPHS 101 AVTARVALSREFVSFFEEHL PIAATSVVSI FGACIMLLVL EFWVGVSAVG 151 ILALFLWLLP RFAAISENLYFRLNNSLERD NHFIRKGDER QLYRHYGLVS 201 RLRVLISNREAFGYLCVGAA MGILFGFAFV MMTLKGYGSA GHIYSVGTYL 251 WMFAMSLDDV PRLVEQYSNLKDIGQRIEWS ERNIKAGT*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 33>:

m006-1.seq 1 ATGTGGAAAA TGTTGAAACA CATAGCCCAA ACCCACCGCA AGCGATTGAT 51TGGCACATTT TCCCTGGTCG GACTGGAAAA CCTTTTGATG CTGGTGTATC 101 CGGTGTTTGGCGGCCGGGCG ATCAATGCCG TGATTGCGGG GGAGGTGTGG 151 CAGGCGTTGC TGTACGCTTTGGTTGTGCTT TTGATGTGGC TGGTCGGTGC 201 GGTGCGGCGG ATTGCCGATA CGCGCACGTTTACGCGGATT TATACCGAAA 251 TCGCCGTGCC GGTCGTGTTG GAACAGCGGC AGCGACAAGTCCCGCATTCG 301 GCGGTAACTG CGCGGGTTGC CCTGTCGCGT GAGTTTGTCA GCTTTTTTGA351 AGAACACCTG CCGATTGCCG CGACATCCGT CGTATCCATA TTCGGCGCGT 401GCATCATGCT GCTGGTGCTG GAATTTTGGG TCGGCGTGTC GGCGGTGGGC 451 ATACTTGCGTTGTTTTTATG GCTTTTGCCA CGTTTTGCCG CCATCAGCGA 501 AAACCTGTAT TTCCGCCTGAACAACAGCTT GGAACGCGAC AACCACTTTA 551 TCCGAAAAGG CGACCGGCGG CAGCTGTACCGCCATTACGG ACTGCTTGCG 601 CGCCTGCGTG TGCTGATTTC CAACCGCGAA GCCTTCGGCTATCTCTGCGT 651 CGGCACGGCG ATGGGTATTT TGTTCGGCTT TGCTTTTGTG ATGATGACGC701 TCAAAGGCTA CAGCAGCGCG GGGCATGTCT ATTCGGTCGG CACTTATCTG 751TGGATGTTTG CCATGAGTTT GGACGACGTG CCGCGATTGG TCGAACAATA 801 TTCCAATTTGAAAGACATCG GACAACGGAT AGAGTGGTCG GAACGGAACA 851 TCAAAGCCGG AACTTGAThis corresponds to the amino acid sequence <SEQ ID 34; ORF 006-1>:

m006-1.pep 1 MWKMLKHIAQ THRKRLIGTF SLVGLENLLM LVYPVFGGRA INAVIAGEVW 51QALLYALVVL LMWLVGAVRR IADTRTFTRI YTEIAVPVVL EQRQRQVPHS 101 AVTARVALSREFVSFFEEHL PIAATSVVSI FGACIMLLVL EFWVGVSAVG 151 ILALFLWLLP RFAAISENLYFRLNNSLERD NHFIRKGDRR QLYRHYGLLA 201 RLRVLISNREAFGYLCVGTA MGILFGFAFV MMTLKGYSSA GHVYSVGTYL 251 WMFAMSLDDV PRLVEQYSNLKDIGQRIEWS ERNIKAGT* m006-1/g006-1 95.5% identity in 288 aa overlap        10        20        30        40        50        60 m006-1.pepMWKMLKHIAQTHRKRLIGTFSLVGLENLLMLVYPVFGGRAINAVIAGEVWQALLYALVVL|||||||||:||||||||||| ||||||||| |||||| ||||||||:|||||||||||: g006-1MWKMLKHIAKTHRKRLIGTFSPVGLENLLMLGYPVFGGWAINAVIAGRVWQALLYALVVF        10        20        30        40        50        60        70        80        90       100       110       120 m006-1.pepLMWLVGAVRRIADTRTFTRIYTEIAVPVVLEQRQRQVPHSAVTARVALSREFVSFFEEHL|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||| g006-1LMWLVGAARRIADTRTFTRIYTEIAVPVVLEQRQRQVPHSAVTARVALSREFVSFFEEHL        70        80        90       100       110       120       130       140       150       160       170       180 m006-1.pepPIAATSVVSIFGACIMLLVLEFWVGVSAVGILALFLWLLPRFAAISENLYFRLNNSLERD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g006-1PIAATSVVSIFGACIMLLVLEFWVGVSAVGILALFLWLLPRFAAISENLYFRLNNSLERD       130       140       150       160       170       180       190       200       210       220       230       240 m006-1.pepNHFIRKGDRRQLYRHYGLLARLRVLISNREAFGYLCVGTAMGILFGFAFVMMTLKGYSSA||||||||:|||||||||::||||||||||||||||||:||||||||||||||||||:|| g006-1NHFIRKGDERQLYRHYGLVSRLRVLISNREAFGYLCVGAAMGILFGFAFVMMTLKGYGSA       190       200       210       220       230       240       250       260       270       280      289 m006-1.pepGHVYSVGTYLWMFAMSLDDVPRLVEQYSNLKDIGQRIEWSERNIKAGTX||:|||||||||||||||||||||||||||||||||||||||||||||| g006-1GHIYSVGTYLWMFAMSLDDVPRLVEQYSNLKDIGQRIEWSERNIKAGTX       250       260       270       280The following partial DNA sequence was identified in N. meningitidis<SEQ ID 35>:

a006-1.seq (partial) 1 ..AGCCAAAACC ACCGCAAGCG ATTGATTGGC ACATTTTTTCTGGTCGGACT 51   GGAAAACCTT TTGATGCTGG TGTATCCGGT GTTTGGCGGC TGGGCGATTA101   ATGCCGTGAT TGCGGGGCAG GCGTGGCAGG CGTTGCTGTA CGCTTTGGTT 151  GTGCTTTTGA TGTGGCTGGT CGGTGCGGCG CGGCGGATTG CCGATACGCG 201  CACGTTTACG CGGATTTATA CCGAAATCGC CGTGCCGGTT GTGTTGGAAC 251  AGCGGCAGCG GCAAGTCCCG CATTCGGCGG TAACTGCGCG GGTTGCCCTG 301  TCGCGTGAGT TTGTCAGCTT TTTTGAAGAA CACCTGCCGA TTGCCGCGAC 351  ATCCGTCGTA TCCATATTCG GCGCGTGCAT CATGCTGCTG GTGCTGGAAT 401  TTTGGGTCGG CGTGTCGGCG GTGGGCATAC TTGCGTTGTT TTTATGGCTT 451  TTGCCACGTT TTGCCGCCAT CAGCGAAAAC CTGTATTTCC GCCTGAAGAA 501  CAGCTTGGAA CGCGACAACC ACTTTATCCG AAAAGGCGAC GAGCGGCAGC 551  TGGACCGCCA TTACGGACTG CTTGCGCGCC TGCGTGTGCT GATTTCCAAC 601  CGCGAAGCCT TCGGCTATCT CTGCGTCGGC ACGGCGATGG GTATTTTGTT 651  CGGCTTTGCT TTTGTGATGA TGACGCTCAA AGGCTACAGC AGCGCGGGGC 701  ATGTCTATTC GGTCGGCACT TATCTGTGGA TGTTTGCCAT AAGTTTGGAC 751  GACGTGCCGC GATTGGTCGA ACAATATTCC AATTTGAAAG ACATCGGACA 801  ACGGATAGAG TGGTCGAAAC GGAACATCAA AGCCGGAACT TGAThis corresponds to the amino acid sequence <SEQ ID 36; ORF 006-1.a>:

a006-1.pep (partial) 1 ..SQNHRKRLIG TFFLVGLENL LMLVYPVFGG WAINAVIAGQAWQALLYALV 51   VLLMWLVGAA RRIADTRTFT RIYTEIAVPV VLEQRQRQVP HSAVTARVAL101   SREFVSFFEE HLPIAATSVV SIFGACIMLL VLEFWVGVSA VGILALFLWL 151  LPRFAAISEN LYFRLKNSLE RDNHFIRKGD ERQLDRHYGL LARLRVLISN 201  REAFGYLCVG TAMGILFGFA FVMMTLKGYS SAGHVYSVGT YLWMFAISLD 251  DVPRLVEQYS NLKDIGQRIE WSKRNIKAGT * a006-1/m006-1 95.7% identity in 280aa overlap                 10        20        30        40        50a006-1.pep         SQNHRKRLIGTFFLVGLENLLMLVYPVFGGWAINAVIAGQAWQALLYALVVL        :|:||||||||| ||||||||||||||||| ||||||||::||||||||||| m006-1MWKMLKHIAQTHRKRLIGTFSLVGLENLLMLVYPVFGGRAINAVIAGEVWQALLYALVVL        10        20        30        40        50        60      60        70        80        90       100       110 a006-1.pepLMWLVGAARRIADTRTFTRIYTEIAVPVVLEQRQRQVPHSAVTARVALSREFVSFFEEHL|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||| m006-1LMWLVGAVRRIADTRTFTRIYTEIAVPVVLEQRQRQVPHSAVTARVALSREFVSFFEEHL        70        80        90       100       110       120     120       130       140       150       160       170 a006-1.pepPIAATSVVSIFGACIMLLVLEFWVGVSAVGILALFLWLLPRFAAISENLYFRLKNSLERD|||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||| m006-1PIAATSVVSIFGACIMLLVLEFWVGVSAVGILALFLWLLPRFAAISENLYFRLNNSLERD       130       140       150       160       170       180     180       190       200       210       220       230 a006-1.pepNHFIRKGDERQLDRHYGLLARLRVLISNREAFGYLCVGTAMGILFGFAFVMMTLKGYSSA||||||||:||| ||||||||||||||||||||||||||||||||||||||||||||||| m006-1NHFIRKGDRRQLYRHYGLLARLRVLISNREAFGYLCVGTAMGILFGFAFVMMTLKGYSSA       190       200       210       220       230       240     240       250       260       270       280 a006-1.pepGHVYSVGTYLWMFAISLDDVPRLVEQYSNLKDIGQRIEWSKRNIKAGTX||||||||||||||:|||||||||||||||||||||||||:|||||||| m006-1GHVYSVGTYLWMFAMSLDDVPRLVEQYSNLKDIGQRIEWSERNIKAGTX       250       260       270       280The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 37>:

g007.seq 1 atgaACACAA CCCGACTGCC GACCGCCTTC ATCTTGTGCT GCCTCTGcgC 51CGCcGCTTCT GCCGccgaca acAGCatcat gaCaAAAGGG CAAAAAGTGT 101 ACGAATCcAactGCATCGCC TGCCACGGCA AGAAAGGGGA AGGGCGCGGC 151 ACTGCGtTTC CTccgctTTTCCggtcgGac tgtattatga acaAACCGCa 201 cgTCCtgctg cacagcatgg tcaaaggcAtcgacgggaca ttcaaagtgg 251 agcggcaaaa cctacgacgg atttatgCcc gcaaccgccatcagcgATGC 301 GGACATTGCC GCCGTCGCCA CTTATATCAT GAACGCCTTT GAThis corresponds to the amino acid sequence <SEQ ID 38; ORF 007.ng>:

g007.pep 1 MNTTRLPTAF ILCCLCAAAS AADNSIMTKG QKVYESNCIA CHGKKGEGRG 51TAFPPLFRSD CIMNKPHVLL HSMVKGIDGT FKVERQNLRR IYARNRHQRC 101 GHCRRRHLYHERL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 39>:

m007.seq 1 ATGAACACAA CCCGACTGCC GACCGCCCTC GTCTTGGGCT GCTTCTGCGC 51CGCCGCTTCT GCCGCCGACA ACAGCATCAT GACAAAAGGG CAAAAAGTGT 101 ACGAATCCAACTGCGTCGCC TGCCACGGCA AAAAGGGCGA AGGCCGCGGA 151 ACCATGTTTC CGCCGCTCTACCGCTCCGAC TTCATCATGA AAAAACCGCA 201 GGTGCTGCTG CACAGCATGG TCAAAGGCATCAACGGTACA ATCAAAGTC. 251 AACGGCAAAA CCTACAACGG ATTCATGCCC GCAACCGCCATCAGCGATGC 301 GGACATTGCC GCCGTCGCCA CTTATATCAT GAACGCCTTT GAThis corresponds to the amino acid sequence <SEQ ID 40; ORF 007>:

m007.pep 1 MNTTRLPTAL VLGCFCAAAS AADNSIMTKG QKVYESNCVA CHGKKGEGRG 51TMFPPLYRSD FIMKKPQVLL HSMVKGINGT IKVXRQNLQR IHARNRHQRC 101 GHCRRRHLYHERL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 41>:

a007.seq 1 ATGAACACAA CCCGACTGCC GACCGCCCTC GTCTTGGGCT GCCTCTGCGC 51CGCCGCTTCT GCCGCCGACA ACAGCATCAT GACAAAAGGG CAAAAAGTGT 101 ACGAATCCAACTGCGTCGCC TGCCACGGCA AAAAGGGCGA AGGCCGCGGA 151 ACCATGTTTC CGCCGCTCTACCGCTCCGAC TTCATCATGA AAAAACCGCA 201 GGTGCTGCTG CACAGCATGG TCAAAGGCATCAACGGTACA ATCAAAGTC. 251 AACGGCAAAA CCTACAACGG ATTCATGCCC GCCACTGCCATCAGCGATGC 301 GGACATTGCC GCCGTCGCCA CTTATATCAT GAACGCCTTT GAThis corresponds to the amino acid sequence <SEQ ID 42; ORF 007.a>:

a007.pep 1 MNTTRLPTAL VLGCLCAAAS AADNSIMTKG QKVYESNCVA CHGKKGEGRG 51TMFPPLYRSD FIMKKPQVLL HSMVKGINGT IKVXRQNLQR IHARHCHQRC 101 GHCRRRHLYHERL* m007/a007 97.3% identity over a 113 aa overlap        10        20        30        40        50        60 m007.pepMNTTRLPTALVLGCFCAAASAADNSIMTKGQKVYESNCVACHGKKGEGRGTMFPPLYRSD||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||| a007MNTTRLPTALVLGCLCAAASAADNSIMTKGQKVYESNCVACHGKKGEGRGTMFPPLYRSD        10        20        30        40        50        60        70        80        90       100       110 m007.pepFIMKKPQVLLHSMVKGINGTIKVXRQNLQRIHARNRHQRCGHCRRRHLYHERLX||||||||||||||||||||||||||||||||||: |||||||||||||||||| a007FIMKKPQVLLHSMVKGINGTIKVXRQNLQRIHARHCHQRCGHCRRRHLYHERLX        70        80        90       100       110Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 007 shows 86.7% identity over a 113 aa overlap with a predicted ORF(ORF 007.ng) from N. gonorrhoeae:

m007/g007         10        20        30        40        50        60m007.pep MNTTRLPTALVLGCFCAAASAADNSIMTKGQKVYESNCVACHGKKGEGRGTMFPPLYRSD|||||||||::| |:|||||||||||||||||||||||:|||||||||||| ||||:||| g007MNTTRLPTAFILCCLCAAASAADNSIMTKGQKVYESNCIACHGKKGEGRGTAFPPLFRSD        10        20        30        40        50        60        70        80        90       100       110 m007.pepFIMKKPQVLLHSMVKGINGTIKVXRQNLQRIHARNRHQRCGHCRRRHLYHERLX ||:||:||||||||||:||:|| ||||:||:||||||||||||||||||||| g007CIMNKPHVLLHSMVKGIDGTFKVERQNLRRIYARNRHQRCGHCRRRHLYHERL        70        80        90       100       110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 43>:

g007-1.seq (partial) 1 ATGAACACAA CCCGACTGCC GACCGCCTTC ATCTTGTGCTGCCTCTGCGC 51 CGCCGCTTCT GCCGCCGACA ACAGCATCAT GACAAAAGGG CAAAAAGTGT 101ACGAATCCAA CTGCATCGCC TGCCACGGCA AGAAAGGGGA AGGGCGCGGC 151 ACTGCGTTTCCTCCGCTTTT CCGGTCGGAC TATATTATGA ACAAACCGCA 201 CGTCCTGCTG CACAGCATGGTCAAAGGCAT CAACGGTACA ATCAAAGTCA 251 ACGGCAAAAC CTACAACGGA TTCATGCCCGCAACCGCCAT CAGCGATGCG 301 GACATTGCCG CCGTCGCCAC TTATATCATG AACGCCTTTGACAACGGCGG 351 CGGAAGCGTT ACCGAAAAAG ACGTAAAACA GGCAAAAGGC AAAAAAAAC.This corresponds to the amino acid sequence <SEQ ID 44; ORF 007-1.ng>:

g007-1.pep (partial) 1 MNTTRLPTAF ILCCLCAAAS AADNSIMTKG QKVYESNCIACHGKKGEGRG 51 TAFPPLFRSD YIMNKPHVLL HSMVKGINGT IKVNGKTYNG FMPATAISDA 101DIAAVATYIM NAFDNGGGSV TEKDVKQAKG KKN...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 45>:

m007-1.seq 1 ATGAACACAA CCCGACTGCC GACCGCCCTC GTCTTGGGCT GCTTCTGCGC 51CGCCGCTTCT GCCGCCGACA ACAGCATCAT GACAAAAGGG CAAAAAGTGT 101 ACGAATCCAACTGCGTCGCC TGCCACGGCA AAAAGGGCGA AGGCCGCGGA 151 ACCATGTTTC CGCCGCTCTACCGCTCCGAC TTCATCATGA AAAAACCGCA 201 GGTGCTGCTG CACAGCATGG TCAAAGGCATCAACGGTACA ATCAAAGTCA 251 ACGGCAAAAC CTACAACGGA TTCATGCCCG CAACCGCCATCAGCGATGCG 301 GACATTGCCG CCGTCGCCAC TTATATCATG AACGCCTTTG ACAACGGCGG351 CGGAAGCGTT ACCGAAAAAG ACGTAAAACA GGCAAAAAGC AAAAAAAACT 401 AAThis corresponds to the amino acid sequence <SEQ ID 46; ORF 007-1>

m007-1.pep 1 MNTTRLPTAL VLGCFCAAAS AADNSIMTKG QKVYESNCVA CHGKKGEGRG 51TMFPPLYRSD FIMKKPQVLL HSMVKGINGT IKVNGKTYNG FMPATAISDA 101 DIAAVATYIMNAFDNGGGSV TEKDVKQAKS KKN* m007-1/g007-1 91.7% identity in 133 aaoverlap         10        20        30        40        50        60m007-1.pep MNTTRLPTALVLGCFCAAASAADNSIMTKGQKVYESNCVACHGKKGEGRGTMFPPLYRSD|||||||||::| |:|||||||||||||||||||||||:|||||||||||| ||||:||| g007-1MNTTRLPTAFILCCLCAAASAADNSIMTKGQKVYESNCIACHGKKGEGRGTAFPPLFRSD        10        20        30        40        50        60        70        80        90       100       110       120 m007-1.pepFIMKKPQVLLHSMVKGINGTIKVNGKTYNGFMPATAISDADIAAVATYIMNAFDNGGGSV:||:||:||||||||||||||||||||||||||||||||||||||||||||||||||||| g007-1YIMNKPHVLLHSMVKGINGTIKVNGKTYNGFMPATAISDADIAAVATYIMNAFDNGGGSV        70        80        90       100       110       120        130m007-1.pep TEKDVKQAKSKKNX |||||||||:||| g007-1 TEKDVKQAKGKKN        130The following partial DNA sequence was identified in N. meningitidis<SEQ ID 47>:

a007-1.seq (partial) 1 ATGAACACAA CCCGACTGCC GACCGCCCTC GTCTTGGGCTGCCTCTGCGC 51 CGCCGCTTCT GCCGCCGACA ACAGCATCAT GACAAAAGGG CAAAAAGTGT 101ACGAATCCAA CTGCGTCGCC TGCCACGGCA AAAAGGGCGA AGGCCGCGGA 151 ACCATGTTTCCGCCGCTCTA CCGCTCCGAC TTCATCATGA AAAAACCGCA 201 GGTGCTGCTG CACAGCATGGTCAAAGGCAT CAACGGTACA ATCAAAGTCA 251 ACGGCAAAAC CTACAACGGA TTCATGCCCGCCACTGCCAT CAGCGATGCG 301 GACATTGCCG CCGTCGCCAC TTATATCATG AACGCCTTTGACAACGGCGG 351 CGGAAGCGTT ACCGAAAAAG ACGTAAAACA GGCAAAAAAC AAAAAA..This corresponds to the amino acid sequence <SEQ ID 48; ORF 007-1.a>:

a007-1.pep (partial) 1 MNTTRLPTAL VLGCLCAAAS AADNSIMTKG QKVYESNCVACHGKKGEGRG 51 TMFPPLYRSD FIMKKPQVLL HSMVKGINGT IKVNGKTYNG FMPATAISDA 101DIAAVATYIM NAFDNGGGSV TEKDVKQAKN KK.. m007-1/a007-1 98.5% identity in132 aa overlap        10        20        30        40        50        60 m007-1.pepMNTTRLPTALVLGCFCAAASAADNSIMTKGQKVYESNCVACHGKKGEGRGTMFPPLYRSD||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||| a007-1MNTTRLPTALVLGCLCAAASAADNSIMTKGQKVYESNCVACHGKKGEGRGTMFPPLYRSD        10        20        30        40        50        60        70        80        90       100       110       120 m007-1.pepFIMKKPQVLLHSMVKGINGTIKVNGKTYNGFMPATAISDADIAAVATYIMNAFDNGGGSV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a007-1FIMKKPQVLLHSMVKGINGTIKVNGKTYNGFMPATAISDADIAAVATYIMNAFDNGGGSV        70        80        90       100       110       120        130m007-1.pep TEKDVKQAKSKKNX |||||||||:|| a007-1 TEKDVKQAKNKK        130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 49>:

g008.seq 1 ATGAACAACA GACATTTTGC CGTCAtcgCC TTGGGCAGCA ACCTTGACAA 51CCCCGCACAA CAAATacgcg gcgcattaga cgcgctctcg tcccatcctg 101 acatccggcttgaaCaggtt tcctcactgt aTatgaccgc acctgtcggt 151 tacgAcaaTC agcccgATTTCATCaatgcc gTCTgcaccg TTTCCACCAC 201 CtTGGACGGC ATTGcccTGC TTGCCgaACTCAAccgTATC GAAGCCGATT 251 TCGGACGCGA aCGCAGTTTC CGCAATGCAC CGCGCACATTGGATTTGGAC 301 ATTATCGACT TTGACGGCAT CTCCAGCGAC GACCCCCGCC TTACCCTGCC351 GCATCCGCGC GCGCACGAAC GCAGTTTCGT CATACGCCCT TTGGCAGAAA 401TCCTCCCTGA TTTTATTTTG GGAAAATACG GAAAGGTTGT CGAATTGTCA 451 AAACGGCTGGGCAATCAAGG CATCCGTCTT TTACCGGACA GGTAAThis corresponds to the amino acid sequence <SEQ ID 50; ORF 008.ng>:

g008.pep 1 MNNRHFAVIA LGSNLDNPAQ QIRGALDALS SHPDIRLEQV SSLYMTAPVG 51YDNQPDFINA VCTVSTTLDG IALLAELNRI EADFGRERSF RNAPRTLDLD 101 IIDFDGISSDDPRLTLPHPR AHERSFVIRP LAEILPDFIL GKYGKVVELS 151 KRLGNQGIRL LPDR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 51>:

m008.seq 1 ATGAACAACA GACATTTTGC CGTCATCGCC CTGGGCAGTA ATCTTGAAAA 51CCCTGCTCAA CAGGTACGCG CCGCATTGGA CACGCTGTCG TCCCATCCTG 101 ACATCCGTCTTAAACAGGCT TCCTCACTGT ATATGACCGC GCCCGTCGGT 151 TACGACAATC AGCCCGATTTTGTCAATGCC GTCTGCACCG TTTCCACCAC 201 TCTGGACGGC ATTGCCyTGC TTGCCGAACTCAACCGTATC GAGGCTGATT 251 TCGGACGCGA ACGCAGCTTC CGCAACGCGC CGCGCACATTGkATTTGGAC 301 ATTATCGACT TTGACGGCAT CTCCAGCGAC GACACsCGAC TcACCtTGCC351 GCATCCGCGC GCGCACGAAC GCAGTTTCGT CATCCGCCCT TTGGCAGAAA 401TCCTCCCTGA TTTTGTTTTA GGAAAACACG GAAAGGTTGC CGAATTGTCA 451 AAACGGyTGGGCAATCAAGG TATCCGTCTT TTACCGGACA GGTAATTThis corresponds to the amino acid sequence <SEQ ID 52; ORF 008>:

m008.pep 1 MNNRHFAVIA LGSNLENPAQ QVRAALDTLS SHPDIRLKQA SSLYMTAPVG 51YDNQPDFVNA VCTVSTTLDG IALLAELNRI EADFGRERSF RNAPRTLXLD 101 IIDFDGISSDDTRLTLPHPR AHERSFVIRP LAEILPDFVL GKHGKVAELS 151 KRLGNQGIRL LPDR*The following partial DNA sequence was identified in N. meningitidis<SEQID 53>:

a008.seq 1 ATGAACAACA GACATTTTGC CGTCATCGCC CTGGGCAGTA ATCTTGAAAA 51CCCTGCCCAA CAGGTACGCG CCGCATTGGA CACGCTGTCG TCCCATCCTG 101 ACATCCGTCTTAAACAGGCT TCCTCACTGT ATATGACCGC GCCCGTCGGT 151 TACGACAATC AGCCCGATTTCGTCAATGCC GTCTGCACCG TTTCCACCAC 201 CTTGGACGGC ATTGCCCTGC TTGCCGAACTCAACCGTATC GAAGCCGATT 251 TCGGACGCGA ACGCAGCTTC CGCAACGCGC CGCGCACATTGGATTTGGAC 301 ATTATCGACT TTGACGGCAT CTCCAGCGAC GACCCCCGAC TCACCCTGCC351 GCATCCGCGC GCGCACGAAC GCAGTTTCGT CATACGCCCT TTGGCAGAAA 401TCCTCCCTGA TTTTATTTTG GGAAAACACG GAAAGGTTGC CGAATTGTCA 451 AAACGGCTGGGCAATCAAGG CATCCGTCTT TTACCGGATA AGTAAThis corresponds to the amino acid sequence <SEQ ID 54; ORF 008.a>:

a008.pep 1 MNNRHFAVIA LGSNLENPAQ QVRAALDTLS SHPDIRLKQA SSLYMTAPVG 51YDNQPDFVNA VCTVSTTLDG IALLAELNRI EADFGRERSF RNAPRTLDLD 101 IIDFDGISSDDPRLTLPHPR AHERSFVIRP LAEILPDFIL GKHGKVAELS 151 KRLGNQGIRL LPDK*m008/a008 97.6% identity over a 164 aa overlap        10        20        30        40        50        60 m008.pepMNNRHFAVIALGSNLENPAQQVRAALDTLSSHPDIRLKQASSLYMTAPVGYDNQPDFVNA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a008MNNRHFAVIALGSNLENPAQQVRAALDTLSSHPDIRLKQASSLYMTAPVGYDNQPDFVNA        10        20        30        40        50        60        70        80        90       100       110       120 m008.pepVCTVSTTLDGIALLAELNRIEADFGRERSFRNAPRTLXLDIIDFDGISSDDTRLTLPHPR||||||||||||||||||||||||||||||||||||| ||||||||||||| |||||||| a008VCTVSTTLDGIALLAELNRIEADFGRERSFRNAPRTLDLDIIDFDGISSDDPRLTLPHPR        70        80        90       100       110       120       130       140       150       160 m008.pepAHERSFVIRPLAEILPDFVLGKHGKVAELSKRLGNQGIRLLPDRX||||||||||||||||||:||||||||||||||||||||||||:| a008AHERSFVIRPLAEILPDFILGKHGKVAELSKRLGNQGIRLLPDKX       130       140       150       160Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 008 shows 92.7% identity over a 164 aa overlap with a predicted ORF(ORF008.ng) from N. gonorrhoeae:

m008/g008         10        20        30        40        50        60m008.pep MNNRHFAVIALGSNLENPAQQVRAALDTLSSHPDIRLKQASSLYMTAPVGYDNQPDFVNA|||||||||||||||:|||||:|:|||:|||||||||:|:|||||||||||||||||:|| g008MNNRHFAVIALGSNLDNPAQQIRGALDALSSHPDIRLEQVSSLYMTAPVGYDNQPDFINA        10        20        30        40        50        60        70        80        90       100       110       120 m008.pepVCTVSTTLDGIALLAELNRIEADFGRERSFRNAPRTLXLDIIDFDGISSDDTRLTLPHPR||||||||||||||||||||||||||||||||||||| ||||||||||||| |||||||| g008VCIVSTILDGIALLAELNRIEADFGRERSFRNAPRILDLDIIDFDGISSDDPRLTLPHPR        70        80        90       100       110       120       130       140       150       160 m008.pepAHERSFVIRPLAEILPDFVLGKHGKVAELSKRLGNQGIRLLPDRX||||||||||||||||||:|||:|||:|||||||||||||||||| g008AHERSFVIRPLAEILPDFILGKYGKVVELSKRLGNQGIRLLPDRX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 55>:

g009.seq 1 ATGCCCCGCG CTGCCGTAGC CTTTGAGCGT CATCATCACA AAAGCAAAGC 51CGAACAAAAT ACCCATCGCC GCGCCGACGC AGAGATAGCC GAAGGCTTCG 101 CGGTTGGAAATCAGCACACG CAGGCGCGAA ACCAGTCCGT AATGGCGGTA 151 CAGCTGCCGC TCGTCGCCTTTTCGGATAAA GTGGTTGTcg cGTTCCAAGC 201 TGTTGTTCAG GCGGAAATAC AGGTTTTCGCTGATGGCGGC AAAACGTGGC 251 AaaaGCCATA AThis corresponds to the amino acid sequence <SEQ ID 56; ORF 009.ng>:

g009.pep 1 MPRAAVAFER HHHKSKAEQN THRRADAEIA EGFAVGNQHT QARNQSVMAV 51QLPLVAFSDK VVVAFQAVVQ AEIQVFADGG KTWQKP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 57>:

m009.seq 1 ATGCCCCGCG CTGCTGTAGC CTTTGAGCGT CATCATCACA AAAGCAAAGC 51CGAACAAAAT ACCCATCGCC GTGCCGACGC AGAGATAGCC GAAGGCTTCG 101 CGGTTGGAAATCAGCACACG CAGGCGCGCA AGCAGTCCGT AATGGCGGTA 151 CAGCTGCCGC CGGTCGCCTTTTCGGATAAA GTGGTTGTCG CGTTCCAAGC 201 TGTTGTTCAG GCGGAAATAC AGGTTTTCGCTGATGGCGGC AAAACGTGGC 251 AAAAGCCATA AThis corresponds to the amino acid sequence <SEQ ID 58; ORF 009>:

m009.pep 1 MPRAAVAFER HHHKSKAEQN THRRADAEIA EGFAVGNQHT QARKQSVMAV 51QLPPVAFSDK VVVAFQAVVQ AEIQVFADGG KTWQKP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 009 shows 97.7% identity over a 86 aa overlap with a predicted ORF(ORF 009.ng) from N. gonorrhoeae:

m009/g009         10        20        30        40        50        60m009.pep MPRAAVAFERHHHKSKAEQNTHRRADAEIAEGFAVGNQHTQARKQSVMAVQLPPVAFSDK|||||||||||||||||||||||||||||||||||||||||||:||||||||| |||||| g009MPRAAVAFERHHHKSKAEQNTHRRADAEIAEGFAVGNQHTQARNQSVMAVQLPLVAFSDK        10        20        30        40        50        60        70        80 m009.pep VVVAFQAVVQAEIQVFADGGKTWQKPX||||||||||||||||||||||||||| g009 VVVAFQAVVQAEIQVFADGGKTWQKPX        70        80The following partial DNA sequence was identified in N. meningitidis<SEQ ID 59>:

a009.seq 1 ATGCCCCGCG CTGCTGTAGC CTTTGAGCGT CATCATCACA AAAGCAAAGC 51CGAACAAAAT ACCCATCGCC GTGCCGACGC AGAGATAGCC GAAGGCTTCG 101 CGGTTGGAAATCAGCACACG CAGGCGCGCA AGCAGTCCGT AATGGCGGTC 151 CAGCTGCCGC TCGTCGCCTTTTCGGATAAA GTGGTTGTCG CGTTCCAAGC 201 TGTTCTTCAG GCGGAAATAC AGGTTTTCGCTGATGGCGGC AAAACGTGGC 251 AAAAGCCATA AThis corresponds to the amino acid sequence <SEQ ID 60; ORF 009.a>:

a009.pep 1 MPRAAVAFER HHHKSKAEQN THRRADAEIA EGFAVGNQHT QARKQSVMAV 51QLPLVAFSDK VVVAFQAVLQ AEIQVFADGG KTWQKP* m009/a009 97.7% identity over a86 aa overlap        10        20        30        40        50        60 m009.pepMPRAAVAFERHHHKSKAEQNTHRRADAEIAEGFAVGNQHTQARKQSVMAVQLPPVAFSDK||||||||||||||||||||||||||||||||||||||||||||||||||||| |||||| a009MPRAAVAFERHHHKSKAEQNTHRRADAEIAEGFAVGNQHTQARKQSVMAVQLPLVAFSDK        10        20        30        40        50        60        70        80 m009.pep VVVAFQAVVQAEIQVFADGGKTWQKPX||||||||:|||||||||||||||||| a009 VVVAFQAVLQAEIQVFADGGKTWQKPX        70        80The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 61>:

g010.seq 1 ATGGGTTTTC CTGTTCGCAA GTTTGATGCC GTGATTGTCG GCGGTGGCGG 51TGCAGGTTTA CGTGCAGCCC TCCAATTATC CAAATCCGGT TTGAATTGTG 101 CCGTTTTGTCTAAAGTGTTC CCGACCCGCT CGCATACCGT AGCGGCGCAG 151 GGCGGTATTT CCGCCTCTCTGGGTAATGTG CAGGAGGACC GTTGGGACTG 201 GCACATGTAC GATACCGTGA AAGGTTCCGACTGGCTGGGC GACCAAGATG 251 CGATTGAGTT TATGTGTCGC GCTGCGCCTG AAGCGGTGATTGAGTTGGAA 301 CACATGGGTA TGCCTTTTGA CCGCGTTGAA AGCGGCAAAA TTTATCAGCG351 TCCTTTCGGC GGACATACTG CCGAACATGG TAAACGTGCG GTAGAACGTG 401CATGTGCGGT TGCCGACCGT ACCGGTCATG CGATGTTGCA TACTTTGTAC 451 CAACAAAACGTCCGTGCCAA TACACAATTC TTTGTGGAAT GGACGGCGCA 501 AGATTTGATT CGTGATGAAAACGGCGATGT CGTCGGCGTA ACCGCCATGG 551 AAATGGAAAC GGGCGAAGTT TATATTTTCCACGCCAAGGC CGTGATGTTT 601 GCTACCGGTG GCGGCGGTCG TATTTATGCT TCTTCTACCAATGCTTATAT 651 GAATACCGGT GACGGTTTGG GCATTTGCGC CCGTGCGGGC ATTCCGTTGG701 AAGATATGGA ATTCTGGCAA TTCCACCCGA CCGGCGTGGC GGGTGCGGGC 751GTGTTGATTA CCGAAGGCGT ACGCGGCGAG GGCGGTATTC TGTTGAacgc 801 cgacggcgaAcgcTTTATGG AAcgctatgc GCcgACCGta aAagaCTTGG 851 CTTCTCGCga cgtGGTTTCACgcgcGatgG CGatggaAAt ctatgaaggt 901 cgcggctgTG GtaaAAAcaA agaCCacgtCTTACTGAAAA TCGACcAtAt 951 cggtGCAGAA AAAATTATGG AAAAACTGCC GGGCATCCGCGAGATTTCCA 1001 TTCagtttgc cGGTATCGAT CCGATTAAAG ACCCGATTcc ggttgTGCCG1051 ACTACCCACT ATATGATGGG CGGCATTCcg aCCAATTATC ACGGTGAAGT 1101TGTTGTTCCG CAAGGCGACG AGTACGAAGT ACCTGTAAAA GGCCTGTATG 1151 CCGCAGGTGAGTGCGCCTGT GCTTCCGTAC ACGGTGCGAA CCGTTTGGGT 1201 ACGAACTCCC TGCTGGACTTGGTGGTGTTC cgcccaaccc cccggtgaThis corresponds to the amino acid sequence <SEQ ID 62; ORF 010.ng>:

g010.pep 1 MGFPVRKFDA VIVGGGGAGL RAALQLSKSG LNCAVLSKVF PTRSHTVAAQ 51GGISASLGNV QEDRWDWHMY DTVKGSDWLG DQDAIEFMCR AAPEAVIELE 101 HMGMPFDRVESGKIYQRPFG GHTAEHGKRA VERACAVADR TGHAMLHTLY 151 QQNVRANTQF FVEWTAQDLIRDENGDVVGV TAMEMETGEV YIFHAKAVMF 201 ATGGGGRIYA SSTNAYMNTG DGLGICARAGIPLEDMEFWQ FHPTGVAGAG 251 VLITEGVRGE GGILLNADGE RFMERYAPTV KDLASRDVVSRAMAMEIYEG 301 RGCGKNKDHV LLKIDHIGAE KIMEKLPGIR EISIQFAGID PIKDPIPVVP351 TTHYMMGGIP TNYHGEVVVP QGDEYEVPVK GLYAAGECAC ASVHGANRLG 401TNSLLDLVVF RPTPR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 63>:

m010.seq (PARTIAL) 1 ..nTCCAATTAT CCAAATCCGG TCTGAATTGT GCCGTTTTGTCTAAAGTGTT 51   CCCGACCCGT TCGCATACCG TAGCGGCGCA GGGCGGTATT TCCGCCTCTn101   TGGGTAATGT GCAGGAAGAC CGTTGGGACT GGCACATGTA CGATACCGTG 151  AAAGGTTCCG ACTGGTTGGG CGACCAAGAT GCGATTGAGT TTATGTGCCG 201  CGCCGCGCCT GAAGCCGTAA TTGAGTTGGA ACACATGGGT ATGCCTTTTG 251  ACCGTGTGGA AAGCGGTAAA ATTTATCAGC GTCCTTTCGG CGGCCATACT 301  GCCGAACACG GTAAACGCGC GGTAGAACGC GyCTGTGCGG TTGCCGACCG 351  TACAGGTCAT GCGATGCTGC ATACTTTGTA CCAACAAAAC GTCCGTGCCA 401  ATACGCAATT CTTTGTGGAA TGGACGGCAC AAGATTTGAT TCGTGATGAA 451  AACGGCGATG TCGTCGGCGT AACCGCCATG GAAATGGAAA CCGGCGAAgT 501  TTATATTTTC CACGCTAAAG CTGTGATGTT TGCTACCGGC GGCGGCGGTC 551  GTATTTATGC GTCTTCTACC AATGCCTATA TGAATACCGG CGATGGTTTG 601  GGTATTTGTG CGCGTGCAGG TATCCCGTTG GAAGACATGG AATTCTGGCA 651  ATTCCAGCCG ACCGGCGTGG CGGGTGCGGG CGTGTTGATT ACCGAA....This corresponds to the amino acid sequence <SEQ ID 64; ORF 010>:

m010.pep (PARTIAL) 1 ..XQLSKSGLNC AVLSKVFPTR SHTVAAQGGI SASXGNVQEDRWDWHMYDTV 51   KGSDWLGDQD AIEFMCRAAP EAVIELEHMG MPFDRVESGK IYQRPFGGHT101   AEHGKRAVER XCAVADRTGH AMLHTLYQQN VRANTQFFVE WTAQDLIRDE 151  NGDVVGVTAM EMETGEVYIF HAKAVMFATG GGGRIYASST NAYMNTGDGL 201  GICARAGIPL EDMEFWQFQP TGVAGAGVLI TE...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 65>:

a010.seq 1 ATGGGCTTTC CTGTTCGCAA GTTTGATGCC GTGATTGTCG GCGGTGGTGG 51TGCAGGTTTA CGCGCANCCC TCCAATTATC CAAATCCGGT CTGAATTGTG 101 CCGTTTTGTCTAAAGTGTTC CCGACCCGTT CGCATACCGT AGCGGCGCAG 151 GGCGGTATTT CCGCCTCTCTGGGTAATGTG CAGGAAGACC GTTGGGACTG 201 GCACATGTAC GATACCGTGA AAGGTTCCGACTGGTTGGGC GACCAAGATG 251 CGATTGAGTT TATGTGCCGC GCCGCGCCTG AAGCCGTAATTGAGTTGGAA 301 CACATGGGTA TGCCTTTTGA CCGTGTGGAA AGCGGTAAAA TTTATCAGCG351 TCCTTTCGGC GGCCATACTG CCGAACACGG TAAACGCGCG GTAGAACGCG 401CCTGTGCNGT TGCCGACCGT ACAGGTCATG CGATGCTGCA TACTTTGTAC 451 CAACAAAATGTCCGTGCCAA TACGCAATTC TTTGTGGAAT GGACGGCACA 501 AGATTTGATT CGTGATGAAAACGGCGATGT CGTCGGCGTA ACCGCCATGG 551 AAATGGAAAC CGGCGAAGTT TATATTTTCCACGCTAAAGC TGTGATGTTT 601 GCTACCGGCG GCGGCGGCCG TATTTATGCG TCTTCTACCAATGCCTATAT 651 GAATACCGGC GATGGTTTGG GTATTTGTGC GCGTGCAGGT ATCCCGTTGG701 AAGACATGGA ATTCTGGCAA TTCCACCCGA CCGGCGTGGC AGGTGCGGGC 751GTGTTGATTA CCGAAGGCGT ACGCGGCGAG GGCGGTATTC TGTTGAATGC 801 CGACGGCGAACGCTTTATGG AACGCTATGC GCCGACCGTA AAAGACTTGG 851 CTTCTCGCGA CGTTGTTTCCCGCGCGATGG CGATGGAAAT CTACGAAGGT 901 CGCGGCTGCG GTAAAAACAA AGACCATGTCTTACTGAAAA TCGACCATAT 951 CGGCGCAGAA AAAATTATGG AAAAACTGCC GGGCATCCGCGAGATTTCCA 1001 TTCAGTTCGC CGGTATCGAT CCGATTAAAG ACCCGATTCC CGTTGTGCCG1051 ACTACCCACT ATATGATGGG CGGTATTCCG ACCAACTACC ATGGCGAAGT 1101TGTCGTTCCT CAAGGCGACG AATACGAAGT GCCTGTAAAA GGTCTGTATG 1151 CGGCAGGTGAGTGCGCCTGT GCTTCCGTAC ACGGTGCGAA CCGCTTGGGT 1201 ACGAACTCCC TGCTGGACTTAGTGGTATTC GGTAAAGCTG CCGGCGACAG 1251 CATGATTAAA TTCATCAAAG AGCAAAGCGACTGGAAACCT TTGCCTGCTA 1301 ATGCCGGCGA ACTGACCCGC CAACGTATCG AGCGTTTGGACAATCAAACT 1351 GATGGTGAAA ACGTTGATGC ATTGCGCCGC GAACTGCAAC GCTCCGTACA1401 ATTGCACGCC GGCGTGTTCC GTACTGATGA GATTCTGAGC AAAGGCGTTC 1451GAGAAGTCAT GGCGATTGCC GAGCGTGTGA AACGTACCGA AATCAAAGAC 1501 AAGAGCAAAGTGTGGAATAC CGCGCGTATC GAGGCTTTGG AATTGGATAA 1551 CCTAATTGAA GTGGCGAAAGCGACTTTGGT GTCTGCCGAA GCACGTAAAG 1601 AATCACGCGG TGCGCACGCT TCAGACGACCATCCTGAGCG CGATGATGAA 1651 AACTGGATGA AACATACGCT GTACCATTCA GATGCCAATACCTTGTCCTA 1701 CAAACCGGTG CACACCAAGC CTTTGAGCGT GGAATACATC AAACCGGCCA1751 AGCGCGTTTA TTGAThis corresponds to the amino acid sequence <SEQ ID 66; ORF 010.a>:

a010.pep 1 MGFPVRKFDA VIVGGGGAGL RAXLQLSKSG LNCAVLSKVF PTRSHTVAAQ 51GGISASLGNV QEDRWDWHMY DTVKGSDWLG DQDAIEFMCR AAPEAVIELE 101 HMGMPFDRVESGKIYQRPFG GHTAEHGKRA VERACAVADR TGHAMLHTLY 151 QQNVRANTQF FVEWTAQDLIRDENGDVVGV TAMEMETGEV YIFHAKAVMF 201 ATGGGGRIYA SSTNAYMNTG DGLGICARAGIPLEDMEFWQ FHPTGVAGAG 251 VLITEGVRGE GGILLNADGE RFMERYAPTV KDLASRDVVSRAMAMEIYEG 301 RGCGKNKDHV LLKIDHIGAE KIMEKLPGIR EISIQFAGID PIKDPIPVVP351 TTHYMMGGIP TNYHGEVVVP QGDEYEVPVK GLYAAGECAC ASVHGANRLG 401TNSLLDLVVF GKAAGDSMIK FIKEQSDWKP LPANAGELTR QRIERLDNQT 451 DGENVDALRRELQRSVQLHA GVFRTDEILS KGVREVMAIA ERVKRTEIKD 501 KSKVWNTARI EALELDNLIEVAKATLVSAE ARKESRGAHA SDDHPERDDE 551 NWMKHTLYHS DANTLSYKPV HTKPLSVEYIKPAKRVY* m010/a010 98.7% identity over a 231 aa overlap                          10        20        30 m010.pep                       XQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASXGNV                        |||||||||||||||||||||||||||||||| ||| a010MGFPVRKFDAVIVGGGGAGLRAXLQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASLGNV        10        20        30        40        50        60 40        50        60        70        80        90 m010.pepQEDRWDWHMYDTVKGSDWLGDQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a010QEDRWDWHMYDTVKGSDWLGDQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFG        70        80        90       100       110       120100       110       120       130       140       150 m010.pepGHTAEHGKRAVERXCAVADRTGHAMLHTLYQQNVRANTQFFVEWTAQDLIRDENGDVVGV||||||||||||| |||||||||||||||||||||||||||||||||||||||||||||| a010GHTAEHGKRAVERACAVADRTGHAMLHTLYQQNVRANTQFFVEWTAQDLIRDENGDVVGV       130       140       150       160       170       180160       170       180       190       200       210 m010.pepTAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a010TAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ       190       200       210       220       230       240220       230 m010.pep FQPTGVAGAGVLITE |:||||||||||||| a010FHPTGVAGAGVLITEGVRGEGGILLNADGERFMERYAPTVKDLASRDVVSRAMAMEIYEG       250       260       270       280       290       300Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 010 shows 98.7% identity over a 231 aa overlap with a predicted ORF(ORF 010.ng) from N. gonorrhoeae:

m010.pep/g010.pep                                10        20        30m010.pep                        XQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASXGNV                        |||||||||||||||||||||||||||||||| ||| g010MGFPVRKFDAVIVGGGGAGLRAALQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASLGNV        10        20        30        40        50        60 40        50        60        70        80        90 m010.pepQEDRWDWHMYDTVKGSDWLGDQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g010QEDRWDWHMYDTVKGSDWLGDQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFG        70        80        90       100       110       120100       110       120       130       140       150 m010.pepGHTAEHGKRAVERXCAVADRTGHAMLHTLYQQNVRANTQFFVEWTAQDLIRDENGDVVGV||||||||||||| |||||||||||||||||||||||||||||||||||||||||||||| g010GHTAEHGKRAVERACAVADRTGHAMLHTLYQQNVRANTQFFVEWTAQDLIRDENGDVVGV       130       140       150       160       170       180160       170       180       190       200       210 m010.pepTAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g010TAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ       190       200       210       220       230       240220       230 m010.pep FQPTGVAGAGVLITE |:||||||||||||| g010FHPTGVAGAGVLITEGVRGEGGILLNADGERFMERYAPTVKDLASRDVVSRAMAMEIYEG       250       260       270       280       290       300The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 67>:

g010-1.seq.. 1 ATGGGTTTTC CTGTTCGCAA GTTTGATGCC GTGATTGTCG GCGGTGGCGG 51TGCAGGTTTA CGTGCAGCCC TCCAATTATC CAAATCCGGT TTGAATTGTG 101CCGTTTTGTC TAAAGTGTTC CCGACCCGCT CGCATACCGT AGCGGCGCAG 151GGCGGTATTT CCGCCTCTCT GGGTAATGTG CAGGAGGACC GTTGGGACTG 201GCACATGTAC GATACCGTGA AAGGTTCCGA CTGGCTGGGC GACCAAGATG 251CGATTGAGTT TATGTGTCGC GCTGCGCCTG AAGCGGTGAT TGAGTTGGAA 301CACATGGGTA TGCCTTTTGA CCGCGTTGAA AGCGGCAAAA TTTATCAGCG 351TCCTTTCGGC GGACATACTG CCGAACATGG TAAACGTGCG GTAGAACGTG 401CATGTGCGGT TGCCGACCGT ACCGGTCATG CGATGTTGCA TACTTTGTAC 451CAACAAAACG TCCGTGCCAA TACACAATTC TTTGTGGAAT GGACGGCGCA 501AGATTTGATT CGTGATGAAA ACGGCGATGT CGTCGGCGTA ACCGCCATGG 551AAATGGAAAC GGGCGAAGTT TATATTTTCC ACGCCAAGGC CGTGATGTTT 601GCTACCGGTG GCGGCGGTCG TATTTATGCT TCTTCTACCA ATGCTTATAT 651GAATACCGGT GACGGTTTGG GCATTTGCGC CCGTGCGGGC ATTCCGTTGG 701AAGATATGGA ATTCTGGCAA TTCCACCCGA CCGGCGTGGC GGGTGCGGGC 751GTGTTGATTA CCGAAGGCGT ACGCGGCGAG GGCGGTATTC TGTTGAACGC 801CGACGGCGAA CGCTTTATGG AACGCTATGC GCCGACCGTA AAAGACTTGG 851CTTCTCGCGA CGTGGTTTCA CGCGCGATGG CGATGGAAAT CTATGAAGGT 901CGCGGCTGTG GTAAAAACAA AGACCACGTC TTACTGAAAA TCGACCATAT 951CGGTGCAGAA AAAATTATGG AAAAACTGCC GGGCATCCGC GAGATTTCCA 1001TTCAGTTTGC CGGTATCGAT CCGATTAAAG ACCCGATTCC GGTTGTGCCG 1051ACTACCCACT ATATGATGGG CGGCATTCCG ACCAATTATC ACGGTGAAGT 1101TGTTGTTCCG CAAGGCGACG AGTACGAAGT ACCTGTAAAA GGCCTGTATG 1151CCGCAGGTGA GTGCGCCTGT GCTTCCGTAC ACGGTGCGAA CCGTTTGGGT 1201ACGAACTCCC TGCTGGACTT GGTGGTGTTC cgcccaaccc cccggtgaThis corresponds to the amino acid sequence <SEQ ID 68; ORF 010-1.ng>:

g010-1.pep 1 MGFPVRKFDA VIVGGGGAGL RAALQLSKSG LNCAVLSKVF PTRSHTVAAQ 51GGISASLGNV QEDRWDWHMY DTVKGSDWLG DQDAIEFMCR AAPEAVIELE 101HMGMPFDRVE SGKIYQRPFG GHTAEHGKRA VERACAVADR TGHAMLHTLY 151QQNVRANTQF FVEWTAQDLI RDENGDVVGV TAMEMETGEV YIFHAKAVMF 201ATGGGGRIYA SSTNAYMNTG DGLGICARAG IPLEDMEFWQ FHPTGVAGAG 251VLITEGVRGE GGILLNADGE RFMERYAPTV KDLASRDVVS RAMAMEIYEG 301RGCGKNKDHV LLKIDHIGAE KIMEKLPGIR EISIQFAGID PIKDPIPVVP 351TTHYMMGGIP TNYHGEVVVP QGDEYEVPVK GLYAAGECAC ASVHGANRLG 401TNSLLDLVVF RPTPR* g010-1/P10444sp|P10444|DHSA_ECOLI SUCCINATE DEHYDROGENASE FLAVOPROTEINSUBUNIT gnl|PID|d1015210 (D90711) Succinate dehydrogenase, flavoprotein[Escherichia coli] gi|1786942 (AE000175) succinate dehydrogenaseflavoprotein subunit [Escherichia coli] Length = 588 Score =1073 (495.6 bits), Expect = 6.7e−169, Sum P(2) = 6.7e−169 Identities =191/303 (63%), Positives = 238/303 (78%) Query: 1MGFPVRKFDAVIVXXXXXXXXXXXXXSKSGLNCAVLSKVFPTRSHTVAAQGGISASLGNV 60M  PVR+FDAV++             S+SG  CA+LSKVFPTRSHTV+AQGGI+ +LGN Sbjct: 1MKLPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVFPTRSHTVSAQGGITVALGNT 60 Query:61 QEDRWDWHMYDTVKGSDWLGDQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFG 120 ED W+WHMYDTVKGSD++GDQDAIE+MC+  PEA++ELEHMG+PF R++ G+IYQRPFG Sbjct: 61HEDNWEWHMYDTVKGSDYIGDQDAIEYMCKTGPEAILELEHMGLPFSRLDDGRIYQRPFG 120 Query:121 GHTAEHGKRAVERACAVADRTGHAMLHTLYQQNVRANTQFFVEWTAQDLIRDENGDVVGV 180 G +  G     R  A ADRTGHA+LHTLYQQN++ +T  F EW A DL+++++G VVG Sbjct: 121GQSKNFGGEQAARTAAAADRTGHALLHTLYQQNLKNHTTIFSEWYALDLVKNQDGAVVGC 180 Query:181 TAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ 240 TA++ETGEV  F A+A + ATGG GRIY S+TNA++NTGDG+G+  RAG+P++DME WQ Sbjct: 181TALCIETGEVVYFKARATVLATGGAGRIYQSTTNAHINTGDGVGMAIRAGVPVQDMEMWQ 240 Query:241 FHPTGVAGAGVLITEGVRGEGGILLNADGERFMERYAPTVKDLASRDVVSRAMAMEIYEG 300FHPTG+AGAGVL+TEG RGEGG LLN  GERFMERYAP  KDLA RDVV+R++ +EI EG Sbjct: 241FHPTGIAGAGVLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGRDVVARSIMIEIREG 300 Query:301 RGC 303 RGC Sbjct: 301 RGC 303 Score = 249 (115.0 bits), Expect =6.7e−169, Sum P(2) = 6.7e−169 Identities = 53/102 (51%), Positives =62/102 (60%) Query: 309HVLLKIDHIGAEKIMEKLPGIREISIQFAGXXXXXXXXXXXXTTHYMMGGIPTNYHGEVV 368H  LK+DH+G E +  +LPGI E+S  FA             T HYMMGGIPT   G+ + Sbjct: 310HAKLKLDHLGKEVLESRLPGILELSRTFAHVDPVKEPIPVIPTCHYMMGGIPTKVTGQAL 369 Query:369 VPQGDEYEVPVKGLYAAGECACASVHGANRLGTNSLLDLVVF 410       +V V GL+A GE AC SVHGANRLG NSLLDLVVF Sbjct: 370TVNEKGEDVVVPGLFAVGEIACVSVHGANRLGGNSLLDLVVF 411The following partial DNA sequence was identified in N. meningitidis<SEQ ID 69>:

m010-1.seq.. 1 ATGGGTTTTC CTGTTCGCAA GTTTGATGCC GTGATTGTCG GCGGTGGTGG 51TGCAGGTTTA CGCGCAGCCC TCCAATTATC CAAATCCGGT CTGAATTGTG 101CCGTTTTGTC TAAAGTGTTC CCGACCCGTT CGCATACCGT AGCGGCGCAg 151GGCGGTATTT CCGCCTCTCT GGGTAATGTG CAGGAAGACC GTTGGGACTG 201GCACATGTAC GATACCGTGA AAGGTTCCGA CTGGTTGGGC GACCAAGATG 251CGATTGAGTT TATGTGCCGC GCCGCGCCTG AAGCCGTAAT TGAGTTGGAA 301CACATGGGTA TGCCTTTTGA CCGTGTGGAA AGCGGTAAAA TTTATCAGCG 351TCCTTTCGGC GGCCATACTG CCGAACACGG TAAACGCGCG GTAGAACGCG 401CCTGTGCGGT TGCCGACCGT ACAGGTCATG CGATGCTGCA TACTTTGTAC 451CAACAAAACG TCCGTGCCAA TACGCAATTC TTTGTGGAAT GGACGGCACA 501AGATTTGATT CGTGATGAAA ACGGCGATGT CGTCGGCGTA ACCGCCATGG 551AAATGGAAAC CGGCGAAGTT TATATTTTCC ACGCTAAAGC TGTGATGTTT 601GCTACCGGCG GCGGCGGTCG TATTTATGCG TCTTCTACCA ATGCCTATAT 651GAATACCGGC GATGGTTTGG GTATTTGTGC GCGTGCAGGT ATCCCGTTGG 701AAGACATGGA ATTCTGGCAA TTCCACCCGA CCGGCGTGGC GGGTGCGGGC 751GTGTTGATTA CCGAAGGCGT ACGCGGCGAG GGCGGTATTC TGTTGAATGC 801CGACGGCGAA CGCTTTATGG AACGCTATGC GCCGACCGTA AAAGACTTGG 851CTTCTCGCGA CGTTGTTTCC CGCGCGATGG CGATGGAAAT CTACGAAGGT 901CGCGGCTGCG GTAAAAACAA AGACCATGTC TTACTGAAAA TCGACCATAT 951CGGCGCAGAA AAAATTATGG AAAAACTGCC GGGCATCCGC GAGATTTCCA 1001TTCAGTTCGC CGGTATCGAT CCGATTAAAG ACCCGATTCC CGTTGTGCCG 1051ACTACCCACT ATATGATGGG CGGCATTCCG ACCAATTACC ACGGCGAAGT 1101TGTCGTTCCG CAAGGTGAAG ATTACGAAGT GCCTGTAAAA GGTCTGTATG 1151CGGCAGGTGA GTGCGCTTGT GCTTCCGTAC ACGGTGCGAA CCGCTTGGGT 1201ACCAACTCCC TGTTGGACTT GGTGGTATTC GGTAAAGCTG CCGGCGACAG 1251CATGATTAAA TTCATCAAAG AGCAAAGCGA CTGGAAACCT TTGCCTGCTA 1301ATGCAGGTGA GTTGACCCGC CAACGTATCG AGCGTTTGGA CAACCAAACC 1351GATGGTGAAA ACGTTGATGC ATTGCGTCGC GAACTGCAAC GCTCTGTACA 1401ACTGCACGCC GGCGTGTTCC GTACTGATGA GATTCTGAGC AAAGGCGTTC 1451GAGAAGTCAT GGCGATTGCC GAGCGTGTGA AACGTACCGA AATCAAAGAC 1501AAGAGCAAAG TGTGGAATAC CGCGCGTATC GAGGCTTTGG AATTGGATAA 1551CCTGATTGAA GTGGCGAAAG CGACTTTGGT GTCTGCCGAA GCACGTAAAG 1601AATCACGCGG TGCGCACGCT TCAGACGACC ATCCTGAGCG CGATGATGAA 1651AACTGGATGA AACATACGCT GTACCATTCA GATATCAATA CCTTGTCCTA 1701CAAACCGGTG CACACCAAGC CTTTGAGCGT GGAATACATC AAACCGGCCA 1751AGCGCGTTTA TTGATGAThis corresponds to the amino acid sequence <SEQ ID 70; ORF 010-1>:

m010-1.pep.. 1 MGFPVRKFDA VIVGGGGAGL RAALQLSKSG LNCAVLSKVF PTRSHTVAAQ 51GGISASLGNV QEDRWDWHMY DTVKGSDWLG DQDAIEFMCR AAPEAVIELE 101HMGMPFDRVE SGKIYQRPFG GHTAEHGKRA VERACAVADR TGHAMLHTLY 151QQNVRANTQF FVEWTAQDLI RDENGDVVGV TAMEMETGEV YIFHAKAVMF 201ATGGGGRIYA SSTNAYMNTG DGLGICARAG IPLEDMEFWQ FHPTGVAGAG 251VLITEGVRGE GGILLNADGE RFMERYAPTV KDLASRDVVS RAMAMEIYEG 301RGCGKNKDHV LLKIDHIGAE KIMEKLPGIR EISIQFAGID PIKDPIPVVP 351TTHYMMGGIP TNYHGEVVVP QGEDYEVPVK GLYAAGECAC ASVHGANRLG 401TNSLLDLVVF GKAAGDSMIK FIKEQSDWKP LPANAGELTR QRIERLDNQT 451DGENVDALRR ELQRSVQLHA GVFRTDEILS KGVREVMAIA ERVKRTEIKD 501KSKVWNTARI EALELDNLIE VAKATLVSAE ARKESRGAHA SDDHPERDDE 551NWMKHTLYHS DINTLSYKPV HTKPLSVEYI KPAKRVY* m010-1/g010-199.5% identity in 410 aa overlap        10        20        30        40        50        60 m010-1.pepMGFPVRKFDAVIVGGGGAGLRAALQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASLGNV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g010-1MGFPVRKFDAVIVGGGGAGLRAALQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASLGNV        10        20        30        40        50        60        70        80        90       100       110       120 m010-1.pepQEDRWDWHMYDTVKGSDWLGDQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g010-1QEDRWDWHMYDTVKGSDWLGDQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFG        70        80        90       100       110       120       130       140       150       160       170       180 m010-1.pepGHTAEHGKRAVERACAVADRTGHAMLHTLYQQNVRANTQFFVEWTAQDLIRDENGDVVGV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g010-1GHTAEHGKRAVERACAVADRTGHAMLHTLYQQNVRANTQFFVEWTAQDLIRDENGDVVGV       130       140       150       160       170       180       190       200       210       220       230       240 m010-1.pepTAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g010-1TAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ       190       200       210       220       230       240       250       260       270       280       290       300 m010-1.pepFHPTGVAGAGVLITEGVRGEGGILLNADGERFMERYAPTVKDLASRDVVSRAMAMEIYEG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g010-1FHPTGVAGAGVLITEGVRGEGGILLNADGERFMERYAPTVKDLASRDVVSRAMAMEIYEG       250       260       270       280       290       300       310       320       330       340       350       360 m010-1.pepRGCGKNKDHVILKIDHIGAEKIMEKLPGIREISIQFAGIDPIKDPIPVVPTTHYMMGGIP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g010-1RGCGKNKDHVLLKIDHIGAEKIMEKLPGIREISIQFAGIDPIKDPIPVVPTTHYMMGGIP       310       320       330       340       350       360       370       380       390       400       410       420 m010-1.pepTNYHGEVVVPQGEDYEVPVKGLYAAGECACASVHGANRLGTNSLLDLVVFGKAAGDSMIK||||||||||||::|||||||||||||||||||||||||||||||||||| g010-1TNYHGEVVVPQGDEYEVPVKGLYAAGECACASVHGANRLGTNSLLDLVVFRPTPRX       370       380       390       400       410       430       440       450       460       470       480 m010-1.pepFIKEQSDWKPLPANAGELTRQRIERLDNQTDGENVDALRRELQRSVQLHAGVFRTDEILSThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 71>:

a010-1.seq.. 1 ATGGGCTTTC CTGTTCGCAA GTTTGATGCC GTGATTGTCG GCGGTGGTGG 51TGCAGGTTTA CGCGCANCCC TCCAATTATC CAAATCCGGT CTGAATTGTG 101CCGTTTTGTC TAAAGTGTTC CCGACCCGTT CGCATACCGT AGCGGCGCAG 151GGCGGTATTT CCGCCTCTCT GGGTAATGTG CAGGAAGACC GTTGGGACTG 201GCACATGTAC GATACCGTGA AAGGTTCCGA CTGGTTGGGC GACCAAGATG 251CGATTGAGTT TATGTGCCGC GCCGCGCCTG AAGCCGTAAT TGAGTTGGAA 301CACATGGGTA TGCCTTTTGA CCGTGTGGAA AGCGGTAAAA TTTATCAGCG 351TCCTTTCGGC GGCCATACTG CCGAACACGG TAAACGCGCG GTAGAACGCG 401CCTGTGCNGT TGCCGACCGT ACAGGTCATG CGATGCTGCA TACTTTGTAC 451CAACAAAATG TCCGTGCCAA TACGCAATTC TTTGTGGAAT GGACGGCACA 501AGATTTGATT CGTGATGAAA ACGGCGATGT CGTCGGCGTA ACCGCCATGG 551AAATGGAAAC CGGCGAAGTT TATATTTTCC ACGCTAAAGC TGTGATGTTT 601GCTACCGGCG GCGGCGGCCG TATTTATGCG TCTTCTACCA ATGCCTATAT 651GAATACCGGC GATGGTTTGG GTATTTGTGC GCGTGCAGGT ATCCCGTTGG 701AAGACATGGA ATTCTGGCAA TTCCACCCGA CCGGCGTGGC AGGTGCGGGC 751GTGTTGATTA CCGAAGGCGT ACGCGGCGAG GGCGGTATTC TGTTGAATGC 801CGACGGCGAA CGCTTTATGG AACGCTATGC GCCGACCGTA AAAGACTTGG 851CTTCTCGCGA CGTTGTTTCC CGCGCGATGG CGATGGAAAT CTACGAAGGT 901CGCGGCTGCG GTAAAAACAA AGACCATGTC TTACTGAAAA TCGACCATAT 951CGGCGCAGAA AAAATTATGG AAAAACTGCC GGGCATCCGC GAGATTTCCA 1001TTCAGTTCGC CGGTATCGAT CCGATTAAAG ACCCGATTCC CGTTGTGCCG 1051ACTACCCACT ATATGATGGG CGGTATTCCG ACCAACTACC ATGGCGAAGT 1101TGTCGTTCCT CAAGGCGACG AATACGAAGT GCCTGTAAAA GGTCTGTATG 1151CGGCAGGTGA GTGCGCCTGT GCTTCCGTAC ACGGTGCGAA CCGCTTGGGT 1201ACGAACTCCC TGCTGGACTT AGTGGTATTC GGTAAAGCTG CCGGCGACAG 1251CATGATTAAA TTCATCAAAG AGCAAAGCGA CTGGAAACCT TTGCCTGCTA 1301ATGCCGGCGA ACTGACCCGC CAACGTATCG AGCGTTTGGA CAATCAAACT 1351GATGGTGAAA ACGTTGATGC ATTGCGCCGC GAACTGCAAC GCTCCGTACA 1401ATTGCACGCC GGCGTGTTCC GTACTGATGA GATTCTGAGC AAAGGCGTTC 1451GAGAAGTCAT GGCGATTGCC GAGCGTGTGA AACGTACCGA AATCAAAGAC 1501AAGAGCAAAG TGTGGAATAC CGCGCGTATC GAGGCTTTGG AATTGGATAA 1551CCTAATTGAA GTGGCGAAAG CGACTTTGGT GTCTGCCGAA GCACGTAAAG 1601AATCACGCGG TGCGCACGCT TCAGACGACC ATCCTGAGCG CGATGATGAA 1651AACTGGATGA AACATACGCT GTACCATTCA GATGCCAATA CCTTGTCCTA 1701CAAACCGGTG CACACCAAGC CTTTGAGCGT GGAATACATC AAACCGGCCA 1751AGCGCGTTTA TTGAThis corresponds to the amino acid sequence <SEQ ID 72; ORF 010-1.a>:

a010-1.pep.. 1 MGFPVRKFDA VIVGGGGAGL RAXLQLSKSG LNCAVLSKVF PTRSHTVAAQ 51GGISASLGNV QEDRWDWHMY DTVKGSDWLG DQDAIEFMCR AAPEAVIELE 101HMGMPFDRVE SGKIYQRPFG GHTAEHGKRA VERACAVADR TGHAMLHTLY 151QQNVRANTQF FVEWTAQDLI RDENGDVVGV TAMEMETGEV YIFHAKAVMF 201ATGGGGRIYA SSTNAYMNTG DGLGICARAG IPLEDMEFWQ FHPTGVAGAG 251VLITEGVRGE GGILLNADGE RFMERYAPTV KDLASRDVVS RAMAMEIYEG 301RGCGKNKDHV LLKIDHIGAE KIMEKLPGIR EISIQFAGID PIKDPIPVVP 351TTHYMMGGIP TNYHGEVVVP QGDEYEVPVK GLYAAGECAC ASVHGANRLG 401TNSLLDLVVF GKAAGDSMIK FIKEQSDWKP LPANAGELTR QRIERLDNQT 451DGENVDALRR ELQRSVQLHA GVFRTDEILS KGVREVMAIA ERVKRTEIKD 501KSKVWNTARI EALELDNLIE VAKATLVSAE ARKESRGAHA SDDHPERDDE 551NWMKHTLYHS DANTLSYKPV HTKPLSVEYI KPAKRVY* m010-1/a010-199.3% identity in 587 aa overlap        10        20        30        40        50        60 a010-1.pepMGFPVRKFDAVIVGGGGAGLRAXLQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASLGNV|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| a010-1MGFPVRKFDAVIVGGGGAGLRAALQLSKSGLNCAVLSKVFPTRSHTVAAQGGISASLGNV        10        20        30        40        50        60        70        80        90       100       110       120 a010-1.pepQEDRWDWHMYDTVKGSDWLGDQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m010-1QEDRWDWHMYDTVKGSDWLGDQDAIEFMCRAAPEAVIELEHMGMPFDRVESGKIYQRPFG        70        80        90       100       110       120       130       140       150       160       170       180 a010-1.pepGHTAEHGKRAVERACAVADRTGHAMLHTLYQQNVRANTQFFVEWTAQDLIRDENGDVVGV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m010-1GHTAEHGKRAVERACAVADRTGHAMLHTLYQQNVRANTQFFVEWTAQDLIRDENGDVVGV       130       140       150       160       170       180       190       200       210       220       230       240 a010-1.pepTAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m010-1TAMEMETGEVYIFHAKAVMFATGGGGRIYASSTNAYMNTGDGLGICARAGIPLEDMEFWQ       190       200       210       220       230       240       250       260       270       280       290       300 a010-1.pepFHPTGVAGAGVLITEGVRGEGGILLNADGERFMERYAPTVKDLASRDVVSRAMAMEIYEG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m010-1FHPTGVAGAGVLITEGVRGEGGILLNADGERFMERYAPTVKDLASRDVVSRAMAMEIYEG       250       260       270       280       290       300       310       320       330       340       350       360 a010-1.pepRGCGKNKDHVLLKIDHIGAEKIMEKLPGIREISIQFAGIDPIKDPIPVVPTTHYMMGGIP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m010-1RGCGKNKDHVLLKIDHIGAEKIMEKLPGIREISIQFAGIDPIKDPIPVVPTTHYMMGGIP       310       320       330       340       350       360       370       380       390       400       410       420 a010-1.pepTNYHGEVVVPQGDEYEVPVKGLYAAGECACASVHGANRLGTNSLLDLVVFGKAAGDSMIK||||||||||||::|||||||||||||||||||||||||||||||||||||||||||||| m010-1TNYHGEVVVPQGEDYEVPVKGLYAAGECACASVHGANRLGTNSLLDLVVFGKAAGDSMIK       370       380       390       400       410       420       430       440       450       460       470       480 a010-1.pepFIKEQSDWKPLPANAGELTRQRIERLDNQTDGENVDALRRELQRSVQLHAGVFRTDEILS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m010-1FIKEQSDWKPLPANAGELTRQRIERLDNQTDGENVDALRRELQRSVQLHAGVFRTDEILS       430       440       450       460       470       480       490       500       510       520       530       540 a010-1.pepKGVREVMAIAERVKRTEIKDKSKVWNTARIEALELDNLIEVAKATLVSAEARKESRGAHA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m010-1KGVREVMAIAERVKRTEIKDKSKVWNTARIEALELDNLIEVAKATLVSAEARKESRGAHA       490       500       510       520       530       540       550       560       570       580 a010-1.pepSDDHPERDDENWMKHTLYHSDANTLSYKPVHTKPLSVEYIKPAKRVYX ||||||||||||||||||||||||||||||||||||||||||||||| m010-1SDDHPERDDENWMKHTLYHSDINTLSYKPVHTKPLSVEYIKPAKRVYX       550       560       570       580The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 73>:

g011.seq 1 ATGAAGACAC ACCGCAAGAC CTGCTCTGCG GTGTGTTTTG CTTTTCAGAC 51GGCATCGAAA CCCGCCGTTT CCATCCGACA TCCCAGCGAG GACATCATGA 101GCCTGAAAAC CCGCCTTACC GAAGATATGA AAACCGCGAT GCGCGCCAAA 151GATCAAGTTT CCCTCGGCAC CATCCGCCTC ATCAATGCCG CCGTCAAACA 201GTTTGAAGTA GACGAACGCA CCGAAGCCGA CGATGCCAAA ATCACCGCCA 251TCCTGACCAA AATGGTCAAA CAGCGCAAAG ACGGCGCGAA AATCTACACT 301GAAGCCGGCC GTCAGGATTT GGCAGACAAA GAAAACGCCG AAATCGACGT 351GCTGCACCGC TACCTGCCGC AAATGCTCTC CGCCGGCGAA ATCCGCACCG 401CCGTCGAAGC AGCCGTTGCC GAAACCGGCG CGGCAGGTAT GGCGGATATG 451GGCAAAGTGA TGGTCGTATT GAAAAcccGC CTCGCCGGCA AAGccgATAT 501GGGCGAAGTC AACAAAATCT TGAAAAccGt aCTGACCGCC tgaThis corresponds to the amino acid sequence <SEQ ID 74; ORF 011.ng>:

g011.pep 1 MKTHRKTCSA VCFAFQTASK PAVSIRHPSE DIMSLKTRLT EDMKTAMRAK 51DQVSLGTIRL INAAVKQFEV DERTEADDAK ITAILTKMVK QRKDGAKIYT 101EAGRQDLADK ENAEIDVLHR YLPQMLSAGE IRTAVEAAVA ETGAAGMADM 151GKVMVVLKTR LAGKADMGEV NKILKTVLTA *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 75>:

m011.seq (partial) 1ATGAGGACAC ACCGCAAGAC CTGCTCTGCG GTGTGTTTTG CTTTTCAGAC 51GGCATCGAAA CCCGCCGTTT CCATCCGACA TCCCAGCGAG GACATCATGA 101GCCTGAAAAT CCGCCTTACC GAAGACATGA AAACCGCGAT GCGCGCCAAA 151GACCAAGTTT CCCTCGGCAC CATCCGCCTC ATCAACGCCG CCGTCAAACA 201GTTTGAAGTG GACGAACGCA CCGAAGCCGA CGATGCCAAA ATCACCGCCA 251TCCTGACCAA AATGGTCAAA CAGCGAAAAG ACAGCGCGAA AATCTACACT 301GAAGCCGGCC GTCAGGATTT GGCAGACAAA GAAAACGCCG AAATCGAGGT 351ACTGCACCGC TACCTTCCCC AAATGCTTTC CGCCGGCGAA ATCCGTACCG 401AGGTCGAAGC TGCCGTTGCC GAAACCGGCG CGGCAGGTAT GGCGGATATG 451GGTAAAGTCA TGGGGCTGCT GAAAACCCGC CTCGCAGGTA AAGCCGA...This corresponds to the amino acid sequence <SEQ ID 76; ORF 011>:

m011.pep (partial) 1MRTHRKTCSA VCFAFQTASK PAVSIRHPSE DIMSLKIRLT EDMKTAMRAK 51DQVSLGTIRL INAAVKQFEV DERTEADDAK ITAILTKMVK QRKDSAKIYT 101EAGRQDLADK ENAEIEVLHR YLPQMLSAGE IRTEVEAAVA ETGAAGMADM 151GKVMGLLKTR LAGKA.....Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 011 shows 95.8% identity over a 165 aa overlap with a predicted ORF(ORF 011.ng) from N. gonorrhoeae:

m011/g011         10        20        30        40        50        60m011.pep MRTHRKTCSAVCFAFQTASKPAVSIRHPSEDIMSLKIRLTEDMKTAMRAKDQVSLGTIRL|:|||||||||||||||||||||||||||||||||| ||||||||||||||||||||||| g011MKTHRKTCSAVCFAFQTASKPAVSIRHPSEDIMSLKTRLTEDMKTAMRAKDQVSLGTIRL        10        20        30        40        50        60        70        80        90       100       110       120 m011.pepINAAVKQFEVDERTEADDAKITAILTKMVKQRKDSAKIYTEAGRQDLADKENAEIEVLHR||||||||||||||||||||||||||||||||||:||||||||||||||||||||:|||| g011INAAVKQFEVDERTEADDAKITAILTKMVKQRKDGAKIYTEAGRQDLADKENAEIDVLHR        70        80        90       100       110       120       130       140       150       160 m011.pepYLPQMLSAGEIRTEVEAAVAETGAAGMADMGKVMGLLKTRLAGKA ||||||||||||||||||||||||||||||||| :||||||||| g011YLPQMLSAGEIRTAVEAAVAETGAAGMADMGKVMVVLKTRLAGKADMGEVNKILKTVLTA       130       140       150       160       170       180 g011 XThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 77>:

g012.seq 1 ATGCTCGCCC GTCGCTATTT TTTCAATATC CAACCCGGGG CGGTTTTCAC 51TGACAAACTG CTTGAACAAC TGATGCGTTT CCTCCAGTTC CTGCCGGAAT 101TTCTGTTTGC CCTTTTCCGT ATTTTCACCC ATAAAAGTAA CCGTGCGCTT 151AAATTCGCCC GCCGTCATCA CATCCACATC AATATCATGT TTTTTCAACa 201gGcggTGGAT ATTCGgcact tccgCcacca cacccaccga accgatgacc 251gcaaacggaG CGGAAACAAT TTTATCCGCc acacacgcca tcatatagcc 301gcCGCTTGCC GCGACCTTAT CGAcggcgac ggTCAGCGGA ATATTGCGTT 351CGCGCAAACG CCTAAGCTGC GAAGCCGCCA AACCGTAACC GTGAACCACG 401CCGCCCGGAC TTTCCAATCT GAGCAGAACC TCATCTTCAG GCTTGGCAAT 451CAAAAGCACC GCCGTAATCT CATGACGCAA GGATTCTACG GCGTGTGCAT 501ACAAATCGCC GTCAAAATCC AACACAAAAA GGCGGGATTT TTGCGTTTCG 551GCAGATTTCT CCCCGCCCTC CTTCAAACGC TTTTTCTCTG CTTTGGCTTC 601CGCCTTTTCC TTTTTCTTTT CTTTTTTTTC CTGATGTTTT GTCTCTTCCT 651 CGCTTAAThis corresponds to the amino acid sequence <SEQ ID 78; ORF 012.ng>:

g012.pep 1 MLARRYFFNI QPGAVFTDKL LEQLMRFLQF LPEFLFALFR IFTHKSNRAL 51KFARRHHIHI NIMFFQQAVD IRHFRHHTHR TDDRKRSGNN FIRHTRHHIA 101AACRDLIDGD GQRNIAFAQT PKLRSRQTVT VNHAARTFQS EQNLIFRLGN 151QKHRRNLMTQ GFYGVCIQIA VKIQHKKAGF LRFGRFLPAL LQTLFLCFGF 201RLFLFLFFFF LMFCLFLA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 79>:

m012.seq 1 ATGCTCGCCC GTTGCCACTT CCTCAATATC CAATTGAGGG CGGTTCTCGC 51TGACAAACTG CTTGAACAAC TGATGCGTTT CCTCCAGTTC CTGTCGGAAT 101TTCTGTTTGC CCTTTTCCGT ATTTTCACCC ATAAAAGTAA CCGTGCGCTT 151AAATTCGCCC GCCGTCATCA CATCCACATC AATATCATGT TTTTTCAACA 201GGCGGTGGAT ATTCGGTACT TCCGCCACCA CACCCACCGA ACCGACAATC 251GCAAACGGAG CGGAAGCAAT TTTATCCGCC ACACACGCCA TCATATAACC 301GCCGCTCGCn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 351nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 401nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 451nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 501nnnnnnnnnn nnnnnnnnnC AACACAAAAA GGCGTGATTT nTGCGTTTCG 551GCAGATTTCT CCCCACCCTC CTTCAAACGT TTTTCcTCTG CTTTGGCTTC 601CGCCTTTTCC TTTTTCTTTT CCTCTTTTTC CTGATGTTGT GCCTCTTCCC 651 CGCTTAAThis corresponds to the amino acid sequence <SEQ ID 80; ORF 012>:

m012.pep 1 MLARCHFLNI QLRAVLADKL LEQLMRFLQF LSEFLFALFR IFTHKSNRAL 51KFARRHHIHI NIMFFQQAVD IRYFRHHTHR TDNRKRSGSN FIRHTRHHIT 101 AARXXXXXXXXXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 151 XXXXXXXXXX XXXXXXXXXXXXXQHKKA*F XRFGRFLPTL LQTFFLCFGF 201 RLFLFLFLFF LMLCLFPA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 81>:

a012.seq 1 ATGCTCGCCC GTTGCCACTT CCTCAATATC CAATTGAGGG CGGTTCTCGC 51TGACAAACTG CTTGAACAAC TGATGCGTTT CCTCCAGTTC CTGTCGGAAT 101 TTCTGTTTGCCCTTTTCCGT ATTTTCACCC ATAAAAGTAA CCGTGCGCTT 151 AAATTCGCCC GCCGTCATCACATCCACATC AATATCATGT TTTTTCAACA 201 GGCGGTGGAT ATTCGGTACT TCCGCTACAACACCCACCGA ACCGACAATC 251 GCAAACGGAG CGGAAACAAT TTTATCCGCC ACACACGCCATCATATAACC 301 ACCGCTCGCC GCCACCTTAT CGACGGCGAC GGTCAGCGGA ATATTGCGTT351 CGCGCAAACG CCTAAGCTGC GAAGCCGCCA AACCGTAACC GTGAACCACG 401CCGCCCGGAC TTTCCAATCT AAGCAGAACC TCATCTTCAG GCTTGGCAAT 451 CAAAAGCACCGCCGTAATCT CATGACGCAA GGATTCTACG GCGTGTGCAT 501 ACAAATCGCC GTCAAAATCCAACACAAAAA GGCGGGATTT TTGCGTTTCG 551 GAAGATTTCT CCCCACCCTC CTTCAAACGCTTTTTCTCTG CTTTGGCTTC 601 CGCCTTTTCC TTTTTCTTTT CCTCTTTTTC CTGATGTTTTGCCTCTTCCC 651 CGCTTAAThis corresponds to the amino acid sequence <SEQ ID 82; ORF 012.a>:

a012.pep 1 MLARCHFLNI QLRAVLADKL LEQLMRFLQF LSEFLFALFR IFTHKSNRAL 51KFARRHHIHI NIMFFQQAVD IRYFRYNTHR TDNRKRSGNN FIRHTRHHIT 101 TARRHLIDGDGQRNIAFAQT PKLRSRQTVT VNHAARTFQS KQNLIFRLGN 151 QKHRRNLMTQ GFYGVCIQIAVKIQHKKAGF LRFGRFLPTL LQTLFLCFGF 201 RLFLFLFLFF LMFCLFPA* m012/a01264.2% identity over a 218 aa overlap        10        20        30        40        50        60 m012.pepMLARCHFLNIQLRAVLADKLLEQLMRFLQFLSEFLFALFRIFTHKSNRALKFARRHHIHI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a012MLARCHFLNIQLRAVLADKLLEQLMRFLQFLSEFLFALFRIFTHKSNRALKFARRHHIHI        10        20        30        40        50        60        70        80        90       100       110       120 m012.pepNIMFFQQAVDIRYFRHHTHRTDNRKRSGSNFIRHTRHHITAARXXXXXXXXXXXXXXXXX|||||||||||||||::|||||||||||:|||||||||||:|| a012NIMFFQQAVDIRYFRYNTHRTDNRKRSGNNFIRHTRHHITTARRHLIDGDGQRNIAFAQT        70        80        90       100       110       120       130       140       150       160       170       180 m012.pepXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQHKKAXF        ::      :                     :              ||||| | a012PKLRSRQTVTVNHAARTFQSKQNLIFRLGNQKHRRNLMTQGFYGVCIQIAVKIQHKKAGF       130       140       150       160       170       180       190       200       210      219 m012.pepXRFGRFLPTLLQTFFLCFGFRLFLFLFLFFLMLCLFPAX ||||||||||||:||||||||||||||||||:|||||| a012LRFGRFLPTLLQTLFLCFGFRLFLFLFLFFLMFCLFPAX        190       200       210Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 012 shows 58.7% identity over a 218 aa overlap with a predicted ORF(ORF 012.ng) from N. gonorrhoeae:

m012/g012         10        20        30        40        50        60m012.pep MLARCHFLNIQLRAVLADKLLEQLMRFLQFLSEFLFALFRIFTHKSNRALKFARRHHIHI|||| :|:|||  ||::|||||||||||||| |||||||||||||||||||||||||||| g012MLARRYFFNIQPGAVFTDKLLEQLMRFLQFLPEFLFALFRIFTHKSNRALKFARRHHIHI        10        20        30        40        50        60        70        80        90       100       110       120 m012.pepNIMFFQQAVDIRYFRHHTHRTDNRKRSGSNFIRHTRHHITAARXXXXXXXXXXXXXXXXX||||||||||||:|||||||||:|||||:||||||||||:|| g012NIMFFQQAVDIRHFRHHTHRTDDRKRSGNNFIRHTRHHIAAACRDLIDGDGQRNIAFAQT        70        80        90       100       110       120       130       140       150       160       170       180 m012.pepXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQHKKAXF        ::      :                     :              ||||| | g012PKLRSRQTVTVNHAARTFQSEQNLIFRLGNQKHRRNLMTQGFYGVCIQIAVKIQHKKAGF       130       140       150       160       170       180       190       200       210      219 m012.pepXRFGRFLPTLLQTFFLCFGFRLFLFLFLFFLMLCLFPAX |||||||:||||:|||||||||||||:||||:||| || g012LRFGRFLPALLQTLFLCFGFRLFLFLFFFFLMFCLFLAX        190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 83>:

m012-1.seq 1 ATGCTCGCCC GTTGCCACTT CCTCAATATC CAATTGAGGG CGGTTCTCGC 51TGACAAACTG CTTGAACAAC TGATGCGTTT CCTCCAGTTC CTGTCGGAAT 101 TTCTGTTTGCCCTTTTCCGT ATTTTCACCC ATAAAAGTAA CCGTGCGCTT 151 AAATTCGCCC GCCGTCATCACATCCACATC AATATCATGT TTTTTCAACA 201 GGCGGTGGAT ATTCGGTACT TCCGCCACCACACCCACCGA ACCGACAATC 251 GCAAACGGAG CGGAAGCAAT TTTATCCGCC ACACACGCCATCATATAACC 301 GCCGCTCGCC GCCACCTTAT CGACGGCGAC GGTCAGCGGA ATATTGCGTT351 CGCGCAAACG CyTAAGCTGC GAAGCCGCCA AACCGTAACC GTGAACCACG 401CCGCCCGGAC TTTCCAATCT GAGCAGAACC TCATCTTCAG GCTTGGCAAT 451 CAAAAGCACCGCCGTAATCT CATGACGCAA GGATTCTACG GCGTGTGCAT 501 ACAAATCGCC GTCAAAATCCAACACAAAAA GGCGGGATTT TTGCGTTTCG 551 GCAGATTTCT CCCCACCCTC CTTCAAACGCTTTTTCTCTG CTTTGGCTTC 601 CGCCTTTTCC TTTTTCTTTT CCTCTTTTTC CTGATGTTTTGCCTCTTCCC 651 CGCTTAAThis corresponds to the amino acid sequence <SEQ ID 84; ORF 012-1>:

m012-1.pep 1 MLARCHFLNI QLRAVLADKL LEQLMRFLQF LSEFLFALFR IFTHKSNRAL 51KFARRHHIHI NIMFFQQAVD IRYFRHHTHR TDNRKRSGSN FIRHTRHHIT 101 AARRHLIDGDGQRNIAFAQT XKLRSRQTVT VNHAARTFQS EQNLIFRLGN 151 QKHRRNLMTQ GFYGVCIQIAVKIQHKKAGF LRFGRFLPTL LQTLFLCFGF 201 RLFLFLFLFF LMFCLFPA* m012-1/g01291.7% identity in 218 aa overlap        10        20        30        40        50        60 m012-1.pepMLARCHFLNIQLRAVLADKLLEQLMRFLQFLSEFLFALFRIFTHKSNRALKFARRHHIHI|||| :|:|||  ||::|||||||||||||| |||||||||||||||||||||||||||| g012MLARRYFFNIQPGAVFTDKLLEQLMRFLQFLPEFLFALFRIFTHKSNRALKFARRHHIHI        10        20        30        40        50        60        70        80        90       100       110       120 m012-1.pepNIMFFQQAVDIRYFRHHTHRTDNRKRSGSNFIRHTRHHITAARRHLIDGDGQRNIAFAQT||||||||||||:|||||||||:|||||:||||||||||:|| | ||||||||||||||| g012NIMFFQQAVDIRHFRHHTHRTDDRKRSGNNFIRHTRHHIAAACRDLIDGDGQRNIAFAQT        70        80        90       100       110       120       130       140       150       160       170       180 m012-1.pepXKLRSRQTVTVNHAARTFQSEQNLIFRLGNQKHRRNLMTQGFYGVCIQIAVKIQHKKAGF ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g012PKLRSRQTVTVNHAARTFQSEQNLIFRLGNQKHRRNLMTQGFYGVCIQIAVKIQHKKAGF       130       140       150       160       170       180       190       200       210      219 m012-1.pepLRFGRFLPTLLQTLFLCFGFRLFLFLFLFFLMFCLFPAX||||||||:||||||||||||||||||:|||||||| || g012LRFGRFLPALLQTLFLCFGFRLFLFLFFFFLMFCLFLAX        190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 85>:

a012-1.seq 1 ATGCTCGCCC GTTGCCACTT CCTCAATATC CAATTGAGGG CGGTTCTCGC 51TGACAAACTG CTTGAACAAC TGATGCGTTT CCTCCAGTTC CTGTCGGAAT 101 TTCTGTTTGCCCTTTTCCGT ATTTTCACCC ATAAAAGTAA CCGTGCGCTT 151 AAATTCGCCC GCCGTCATCACATCCACATC AATATCATGT TTTTTCAACA 201 GGCGGTGGAT ATTCGGTACT TCCGCTACAACACCCACCGA ACCGACAATC 251 GCAAACGGAG CGGAAACAAT TTTATCCGCC ACACACGCCATCATATAACC 301 ACCGCTCGCC GCCACCTTAT CGACGGCGAC GGTCAGCGGA ATATTGCGTT351 CGCGCAAACG CCTAAGCTGC GAAGCCGCCA AACCGTAACC GTGAACCACG 401CCGCCCGGAC TTTCCAATCT AAGCAGAACC TCATCTTCAG GCTTGGCAAT 451 CAAAAGCACCGCCGTAATCT CATGACGCAA GGATTCTACG GCGTGTGCAT 501 ACAAATCGCC GTCAAAATCCAACACAAAAA GGCGGGATTT TTGCGTTTCG 551 GAAGATTTCT CCCCACCCTC CTTCAAACGCTTTTTCTCTG CTTTGGCTTC 601 CGCCTTTTCC TTTTTCTTTT CCTCTTTTTC CTGATGTTTTGCCTCTTCCC 651 CGCTTAAThis corresponds to the amino acid sequence <SEQ ID 86; ORF 012-1.a>:

a012-1.pep 1 MLARCHFLNI QLRAVLADKL LEQLMRFLQF LSEFLFALFR IFTHKSNRAL 51KFARRHHIHI NIMFFQQAVD IRYFRYNTHR TDNRKRSGNN FIRHTRHHIT 101 TARRHLIDGDGQRNIAFAQT PKLRSRQTVT VNHAARTFQS KQNLIFRLGN 151 QKHRRNLMTQ GFYGVCIQIAVKIQHKKAGF LRFGRFLPTL LQTLFLCFGF 201 RLFLFLFLFF LMFCLFPA* a012-1/m012-197.2% identity in 218 aa overlap        10        20        30        40        50        60 a012-1.pepMLARCHFLNIQLRAVLADKLLEQLMRFLQFLSEFLFALFRIFTHKSNRALKFARRHHIHI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m012-1MLARCHFLNIQLRAVLADKLLEQLMRFLQFLSEFLFALFRIFTHKSNRALKFARRHHIHI        10        20        30        40        50        60        70        80        90       100       110       120 a012-1.pepNIMFFQQAVDIRYFRYNTHRTDNRKRSGNNFIRHTRHHITTARRHLIDGDGQRNIAFAQT|||||||||||||||::|||||||||||:|||||||||||:||||||||||||||||||| m012-1NIMFFQQAVDIRYFRHHTHRTDNRKRSGSNFIRHTRHHITAARRHLIDGDGQRNIAFAQT        70        80        90       100       110       120       130       140       150       160       170       180 a012-1.pepPKLRSRQTVTVNHAARTFQSKQNLIFRLGNQKHRRNLMTQGFYGVCIQIAVKIQHKKAGF |||||||||||||||||||:||||||||||||||||||||||||||||||||||||||| m012-1XKLRSRQTVTVNHAARTFQSEQNLIFRLGNQKHRRNLMTQGFYGVCIQIAVKIQHKKAGF       130       140       150       160       170       180       190       200       210      219 a012-1.pepLRFGRFLPTLLQTLFLCFGFRLFLFLFLFFLMFCLFPAX||||||||||||||||||||||||||||||||||||||| m012-1LRFGRFLPTLLQTLFLCFGFRLFLFLFLFFLMFCLFPAX        190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 87>:

g013.seq 1 aTgcctttga ccatgctgtg cagcaGGAcg tGCGGTTtgt tcataataca 51gtCcgaccGG AAAagcggAG GAAaCGCAGT GCCGCGCCCT TCCCCTTTCT 101 TGCCGTGGCAGGCGATGCag tTgGATTCGT ACACTTTTTG CCCTTTtGtc 151 atgatGCTgt tgtcggCGGCAGAAGCgGCG GcgCAGAGGC AGCACAAGAT 201 GAAGGCGGTC GGCAGTCGGG TTGTGTtcattGgcgTTTCC cctaatgttt 251 tgaaaccttg ttttttgatt Ttgcctttac ggggtgaaaagtttttTtgg 301 cccaaatccg gaatttagThis corresponds to the amino acid sequence <SEQ ID 88; ORF 013.ng:

g013.pep 1 MPLTMLCSRT CGLFIIQSDR KSGGNAVPRP SPFLPWQAMQ LDSYTFCPFV 51MMLLSAAEAA AQRQHKMKAV GSRVVFIGVS PNVLKPCFLI LPLRGEKFFW 101 PKSGI*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 89>:

m013.seq 1 ATGCCTTTGA CCATGCTGTG CAGCAGCACC TGCGGTTTTT TCATGATGAA 51GTCGGAGCGG TAGAGCGGCG GAAACATGGT TCCGCGGCCT TCGCCCTTTT 101 TGCCGTGGCAGGCGACGCAG TTGGATTCGT ACACTTTTTG CCCTTTTGTC 151 ATGATGCTGT TGTCGGCGGCAGAAGCGGCG GCGCAGAAGC AGCCCAAGAC 201 GAGGGCGGTC GGCAGTCGGG TTGTGTTCATTGGTGTTTCC TTCATGTTTG 251 AAACCTTGTT GTTGATTTTG CGTAGCGGGT GAAAGATTTTTTTGCCGAAT 301 CAGTAGThis corresponds to the amino acid sequence <SEQ ID 90; ORF 013>:

m013.pep 1 MPLTMLCSST CGFFMMKSER XSGGNMVPRP SPFLPWQATQ LDSYTFCPFV 51MMLLSAAEAA AQKQPKTRAV GSRVVFIGVS FMFETLLLIL RSGXKIFLPN 101 Q*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 91>:

a013.seq 1 ATGCCTTTGA CCATGCTGTG CAGCAGCACC TGCGGTTTTT TCATGATGAA 51GTCGGAGCGG TAGAGCGGCG GAAACATGGT TCCGCGGCCT TCGCCCTTTT 101 TGCCGTGGCAGGCGACGCAG TTGGATTCGT ACACTTTTTG CCCTTTTGTC 151 ATGATGCTGT TGTCGGCGGCAGAAGCGGCG GCGCAGAGGC AGCCCAAGAC 201 GAGGGCGGTC GGCAGTCGGG TTGTGTTCATTGGTGTTTCC TTAATGTTTG 251 AAACCTTGTT GTTGATTTTG CGTAGCGGGT GAAAGATTTTCTTGCCGAAT 301 CGGTAGThis corresponds to the amino acid sequence <SEQ ID 92; ORF 013.a>:

a013.pep 1 MPLTMLCSST CGFFMMKSER *SGGNMVPRP SPFLPWQATQ LDSYTFCPFV 51MMLLSAAEAA AQRQPKTRAV GSRVVFIGVS LMFETLLLIL RSG*KIFLPN 101 R* m013/a01397.0% identity over a 101 aa overlap        10        20        30        40        50        60 m013.pepMPLTMLCSSTCGFFMMKSERXSGGNMVPRPSPFLPWQATQLDSYTFCPFVMMLLSAAEAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a013MPLTMLCSSTCGFFMMKSERXSGGNMVPRPSPFLPWQATQLDSYTFCPFVMMLLSAAEAA        10        20        30        40        50        60        70        80        90       100 m013.pepAQKQPKTRAVGSRVVFIGVSFMFETLLLILRSGXKIFLPNQX||:|||||||||||||||||:|||||||||||||||||||:| a013AQRQPKTRAVGSRVVFIGVSLMFETLLLILRSGXKIFLPNRX        70        80        90       100Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 013 shows 73.3% identity over a 101 aa overlap with a predicted ORF(ORF 013.ng) from N. gonorrhoeae:

m013/g013         10        20        30        40        50        60m013.pep MPLTMLCSSTCGFFMMKSERXSGGNMVPRPSPFLPWQATQLDSYTFCPFVMMLLSAAEAA|||||||| |||:|:::|:| |||| |||||||||||| ||||||||||||||||||||| g013MPLTMLCSRTCGLFIIQSDRKSGGNAVPRPSPFLPWQAMQLDSYTFCPFVMMLLSAAEAA        10        20        30        40        50        60        70        80         90        100 m013.pepAQKQPKTRAVGSRVVFIGVSF-MFETLLLILR-SGXKIFLPNQX||:| | :||||||||||||  :::  :|||   | |:| |: g013AQRQHKMKAVGSRVVFIGVSPNVLKPCFLILPLRGEKFFWPKSGIX        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 93>:

g015.seq 1 ATGCAGTATC TGATTGTCAA ATACAGCCAT CAAATCTTCG TTACCATCAC 51CATTTTGGTA TTCAACATCC GTTTTTTCCT ACTTTGGAAA AATCCAGAAA 101 AGCCCTTGGTCGGCTTTTGG AAAGCACTGC CCCACCTCAA CGACACGATG 151 CTGCTGTTTA CGGGATTGTGGCTGATGAAG ATTACCCATT TCTCCCCGTT 201 CAACGCGCCT TGGCTCGGCA CAAAAATCCTGCTCCTGTTC GCCTACATCG 251 CACTGGGCAT GGTAATGATG CGCGCCCGTC CGCGTTCGACCAAGTTCTAC 301 ACCGTTTACC TGCTCGCTAT GTGTTGCATC GCCTGCATCG TTTACCTTGC351 CAAAACCAAA GTCCTGCCAT TCTGAThis corresponds to the amino acid sequence <SEQ ID 94; ORF 015.ng>:

g015.pep 1 MQYLIVKYSH QIFVTITILV FNIRFFLLWK NPEKPLVGFW KALPHLNDTM 51LLFTGLWLMK ITHFSPFNAP WLGTKILLLF AYIALGMVMM RARPRSTKFY 101TVYLLAMCCI ACIVYLAKTK VLPF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 95>:

m015.seq (partial) 1 ..AAAATCAGAA AAGCCTTGGC GGGCTTTTGG AAGGCACTGCCCCACCTTAA 51   CGACACCATG CTGCTGTTTA CGGGATTGTG GCTGATGAAA ATTACCCATT101   TCTCCCCGTT CAACGCGCCT TGGCTCGGTA CAAAAATCCT GCTTCTGCTC 151  GCCTATATCG CATTGGGTAT GATGATGATG CGCGCCCGTC CGCGTTCGAC 201  CAAGTTCTAC ACCGTTTACC TGCTCGCCAT GTGTTGCGTC GCCTGCATCG 251  TTTACCTTGC CAAAACCAAA GTCCTGCCTT TCTGAThis corresponds to the amino acid sequence <SEQ ID 96; ORF 015:

m015.pep (partial) 1 ..KIRKALAGFW KALPHLNDTM LLFTGLWLMK ITHFSPFNAPWLGTKILLLL 51   AYIALGMMMM RARPRSTKFY TVYLLAMCCV ACIVYLAKTK VLPF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 97>:

a015.seq 1 ATGCAGTATC TGATTGTCAA ATACAGCCAT CAAATCTTCG TTACCATCAC 51CATTTTGGTA TTCAACATCC GTGTTTTCNT ACTTTGGAAA AATCCAGAAA 101 AGCCCTTGGCGGGCTTTTGG AAGGCACTGC CCCACCTTAA CGACACCATG 151 CTGCTGTTTA CGGGATTGTGGCTGATGAAA ATTACCCATT TCTCCCCGTT 201 CAACGCGCCT TGGCTCGGTA CAAAAATCCTGCTTCTGCTC GCCTATATCG 251 CATTGGGTAT GATGATGATG CGCGCCCGTC CGCGTTCGACCAAGTTCTAC 301 ACCGTTTACC TGCTCGCCAT GTGTTGCCTC ACCTGCATCG TTTACCTTGC351 CAAAACCAAA GTCCTGCCTT TCTGAThis corresponds to the amino acid sequence <SEQ ID 98; ORF 015.a>:

a015.pep 1 MQYLIVKYSH QIFVTITILV FNIRVFXLWK NPEKPLAGFW KALPHLNDTM 51LLFTGLWLMK ITHFSPFNAP WLGTKILLLL AYIALGMMMM RARPRSTKFY 101TVYLLAMCCL TCIVYLAKTK VLPF* m015/a015 96.7% identity over a 91 aaoverlap                                    10        20        30m015.pep                            KIRKALAGFWKALPHLNDTMLLFTGLWLMKITH                              | |||||||||||||||||||||||||||| a015LIVKYSHQIFVTITILVFNIRVFXLWKNPEKPLAGFWKALPHLNDTMLLFTGLWLMKITH     10        20        30        40        50        60     40        50        60        70        80        90 m015.pepFSPFNAPWLGTKILLLLAYIALGMMMMRARPRSTKFYTVYLLAMCCVACIVYLAKTKVLP||||||||||||||||||||||||||||||||||||||||||||||::|||||||||||| a015FSPFNAPWLGTKILLLLAYIALGMMMMRARPRSTKFYTVYLLAMCCLTCIVYLAKTKVLP     70        80        90       100       110       120 m015.pep FX ||a015 FXComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 015 shows 94.5% identity over a 91 aa overlap with a predicted ORF(ORF 015.ng) from N. gonorrhoeae:

m015/g015                                    10        20        30m015.pep                            KIRKALAGFWKALPHLNDTMLLFTGLWLMKITH                              | |:|||||||||||||||||||||||||| g015LIVKYSHQIFVTITILVFNIRFFLLWKNPEKPLVGFWKALPHLNDTMLLFTGLWLMKITH     10        20        30        40        50        60     40        50        60        70        80        90 m015.pepFSPFNAPWLGTKILLLLAYIALGMMMMRARPRSTKFYTVYLLAMCCVACIVYLAKTKVLP||||||||||||||||:|||||||:|||||||||||||||||||||:||||||||||||| g015FSPFNAPWLGTKILLLFAYIALGMVMMRARPRSTKFYTVYLLAMCCIACIVYLAKTKVLP     70        80        90       100       110       120 m015.pep FX ||g015 FXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 99>:

g018.seq 1 atGCAGCAGG GGCagttggt tggacgcgtc gcccgcaata AAGATATGCG 51GAATgctggt CTGCATggtC AGCGGATCGG CAACGGGtac gccgcgcgcg 101 tctttgTCGATATTGATGTT TTCCAAACCG ATATtgTCAA CGTTCGGACG 151 GCgACCTACG GCTGCCAACATATATTCGGC AACAAATACG CCTTTTTCGC 201 CATCCTGCTC CCAATGGACT tctACATTGCCGTCTGCGTC GAGTTTGACC 251 TCGGTTTTAG CATCCAGATG CAGTTTCAAT tctTCTCCGAACACGGCTTT 301 CGCCTCGTCT GAThis corresponds to the amino acid sequence <SEQ ID 100; ORF 018.ng>:

g018.pep 1 MQQGQLVGRV ARNKDMRNAG LHGQRIGNGY AARVFVDIDV FQTDIVNVRT 51ATYGCQHIFG NKYAFFAILL PMDFYIAVCV EFDLGFSIQM QFQFFSEHGF 101 RLV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 101>:

m018.seq 1 ATGCAGCAGA GGCAGTTGGT TGGACGCATC GCCTGCGATG AAGATATGCG 51GAATACTGGT CTGCATGGTC AGCGGGTCGG CAACAGGTAC GCCGCGCGCA 101 TCTTTTTCGATATTGATATT TTCCAAACCG ATATTGTCAA CGTTCGGACG 151 GCGGCCCACG GCTGCCAGCATATATTCGGC AACAAATACG CCTTTTTCGC 201 CATCCTGCTC CCAATGGACT TCTACATTGCCGTCTGCATC GAGTTTGACC 251 TCGGTTTTAG CATCCAGATG CAGTTTCAAT TCTTCGCCGAACACGGCGTT 301 CGCCTCGTCT GAThis corresponds to the amino acid sequence <SEQ ID 102; ORF 018>:

m018.pep 1 MQQRQLVGRI ACDEDMRNTG LHGQRVGNRY AARIFFDIDI FQTDIVNVRT 51AAHGCQHIFG NKYAFFAILL PMDFYIAVCI EFDLGFSIQM QFQFFAEHGV 101 RLV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 103>:

a018.seq 1 ATGCAGCAGG GGCAGTTGGT TGGACGCGTC GCCCGCAATA AAGATATGCG 51GAATACTGGT CTGCATAGTC AGCGGATCGG CAACGGGTAC GCCGCGCGCA 101 TCTTTTTCGATATTGATGTT TTCCAAACCG ATATTGTCAA CGTTCGGACG 151 GCGGCCTACG GCTGCCAGCATATATTCGGC AACAAATACG CCTTTTTCGC 201 CATCCTGCTC CCAATGGACT TCTACATTGCCGTCTGCGTC GAGTTTGGCC 251 TCGGTTTTAG CATCCAAATG CAGTTTCAAT TCTTCACCGAACACGGCTTT 301 CGCCTCGTCT GAThis corresponds to the amino acid sequence <SEQ ID 104; ORF 018.a>:

a018.pep 1 MQQGQLVGRV ARNKDMRNTG LHSQRIGNGY AARIFFDIDV FQTDIVNVRT 51AAYGCQHIFG NKYAFFAILL PMDFYIAVCV EFGLGFSIQM QFQFFTEHGF 101 RLV*m018/a018 86.4% identity over a 103 aa overlap        10        20        30        40        50        60 m018.pepMQQRQLVGRIACDEDMRNTGLHGQRVGNRYAARIFFDIDIFQTDIVNVRTAAHGCQHIFG||| |||||:| ::||||||||:||:|| ||||||||||:||||||||||||:||||||| a018MQQGQLVGRVARNKDMRNTGLHSQRIGNGYAARIFFDIDVFQTDIVNVRTAAYGCQHIFG        10        20        30        40        50        60        70        80        90       100 m018.pepNKYAFFAILLPMDFYIAVCIEFDLGFSIQMQFQFFAEHGVRLVX|||||||||||||||||||:|| ||||||||||||:||| |||| a018NKYAFFAILLPMDFYIAVCVEFGLGFSIQMQFQFFTEHGFRLVX        70        80        90       100Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 018 shows 84.5% identity over a 103 aa overlap with a predicted ORF(ORF 018.ng) from N. gonorrhoeae:

m018/g018         10        20        30        40        50        60m018.pep MQQRQLVGRIACDEDMRNTGLHGQRVGNRYAARIFFDIDIFQTDIVNVRTAAHGCQHIFG||| |||||:| ::||||:||||||:|| ||||:| |||:|||||||||||::||||||| g018MQQGQLVGRVARNKDMRNAGLHGQRIGNGYAARVFVDIDVFQTDIVNVRTATYGCQHIFG        10        20        30        40        50        60        70        80        90       100 m018.pepNKYAFFAILLPMDFYIAVCIEFDLGFSIQMQFQFFAEHGVRLVX|||||||||||||||||||:|||||||||||||||:||| |||| g018NKYAFFAILLPMDFYIAVCVEFDLGFSIQMQFQFFSEHGFRLVX        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 105>:

g019.seq (partial) 1 ..ctgctggcgg ccctggtgct tgccgcgtgt tcttcgACAAACAcacTGCC 51   AGCCGGCAAG ACCCCGGCAG ACAATATAGA AActgcCgAC CTTTCGGCAA101   GCGTTCCCAC ccgcCCTGCC GAACCGGAAG GAAAAACGCT GGCAGATTAC 151  GGCGGCTACC CGTCCGCACT GGATGCAGTG AAACAGAACA ACGATGCGGC 201  AGCCGCCGCC TATTTGGAAA Acgcaggaga cagCGcgatg gcGGAAAatg 251  tccgcaagga gtgGCTGaThis corresponds to the amino acid sequence <SEQ ID 106; ORF 019.ng>:

g019.pep (partial) 1 ..LLAALVLAAC SSTNTLPAGK TPADNIETAD LSASVPTRPAEPEGKTLADY 51   GGYPSALDAV KQNNDAAAAA YLENAGDSAM AENVRKEWL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 107>:

m019.seq (partial) 1 ATGTACCTAC CCTCTATGAA GCATTCCCTG CCGCTGCTGGCGGCCCTGGT 51 GCTTGCCGCG TGTTCTTCGA CAAACACACT GCCAGCCGGC AAGACCCCGG 101CAGACAATAT AGAAACTGCC GACCTTTCGG CAAGCGTTCC CACCCGCCCT 151 GCCGAACCCGAAAGAAAAAC GCTGGCAGAT TACGGCGGCT ACCCGTCCGC 201 ACTGGATGCA GTGAAACAGAAAAACGATGC CGCCGTCGCC GCCTATTTGG 251 AAAACGCCGG CGACAGCGCG ATGGCGGAAAATGTCCGCAA CGAGTGGCTG 301 AAGTCTTTGG GCGCACGCAG ACAGTGGACG CTGTTTGCACAGGAATACGC 351 CAAACTCGAA CCGGCAGGGC GCGCCCAAGA AGTCGAATGC TACGCCGATT401 CGAGCCGCAA CGACTATACG CGTGCCGCTG AACTGGTCAA AAATACGGGC 451AAACTGCCTT CGGGCTGCAC CAAACTGTTG GAACAGGCAG CCGCATCCGG 501 CTTGTTGGACGGCAACGACG CCTGGAGGCG CGTGCGCGGA CTGCTGGCCG 551 GCCGCCAAAC CACAGACGCACGCAACCTTG CCGCCGCATT GGGCAGCCCG 601 TTTGACGGCG GTACACAAGG TTCGCGCGAATATGCCCTGT TGAACGTCAT 651 CGGCAAAGAA GCACGCAAAT CGCCGAATGC CGCCGCCCTGCTGTCCGAAA 701 TGGAAAGCGG TTTAAGCCTC GAACAACGCA GTTTCGCGTG GGGCGTATTG751 GGGCATTATC AGTCGCAAAA CCTCAATGTG CCTGCCGCCT TGGACTATTA 801CGGCAAGGTT GCCGACCGCC GCCAACTGAC CGACGACCAA ATCGAGTGGT 851 ACGCCCGCGCCGCCTTGCGC GCCCGACGTT GGGACGAGCT GGCCTCCGTT 901 ATCTCGCATA TGCCCGAAAAACTGCAAAAA AGCCCGACCT GGCTCTACTG 951 GCTGGCACGC AGCCGCGCCG CAACGGGCAACACGCAAGAG GCGGAAAAAC 1001 TTTACAAACA GGCGGCAGCG ACGGGCAGGA ATTTTTATGCGGTGCTGGCA 1051 GGGGAAGAAT TGGGTCGGAA AATCGATACG CGCAACAATG TGCCCGATGC1101 CGGCAAAAAC AGCGTCCGCC GCATGGCGGA AGACGGTGCA GTCAAACGCG 1151CACTGGTACT GTTCCAAAAC AGCCAATCTG CCGGTGATGC AAAAATGCGC 1201 CGTCAGGCTCAGGCGGAATG GCGTTTTGCC ACACGCGGCT TTGACGAAGA 1251 CAAGCTGCTG ACCGCCGCGCAAACCGCGTT CGACCACGGT TTTTACGATA 1301 TGGCGGTCAA CAGCGCGGAA CGCACCGACCGCAAACTCAA CTACACCTTG 1351 CGCTATATTT CGCCGTTTAA AGACACGGTA ATCCGCCACGCGCAAAATGT 1401 TAATGTCGAT CCGGCTTGGG TTTATGGGCT GATTCGTCAG GAAAGCCGCT1451 TCGTTATAGG CGCGCAATCC CGCGTAGGCG CGCAGGGGCT GATGCAGGTT 1501ATGCCTGCCA CCGCGCGCGA AATCGCCGGC AAAATCGGTA TGGATGCCGC 1551 ACAACTTTACACCGCCGACG GG...This corresponds to the amino acid sequence <SEQ ID 108; ORF 019>:

m019.pep (partial) 1 MYLPSMKHSL PLLAALVLAA CSSTNTLPAG KTPADNIETADLSASVPTRP 51 AEPERKTLAD YGGYPSALDA VKQKNDAAVA AYLENAGDSA MAENVRNEWL 101KSLGARRQWT LFAQEYAKLE PAGRAQEVEC YADSSRNDYT RAAELVKNTG 151 KLPSGCTKLLEQAAASGLLD GNDAWRRVRG LLAGRQTTDA RNLAAALGSP 201 FDGGTQGSRE YALLNVIGKEARKSPNAAAL LSEMESGLSL EQRSFAWGVL 251 GHYQSQNLNV PAALDYYGKV ADRRQLTDDQIEWYARAALR ARRWDELASV 301 ISHMPEKLQK SPTWLYWLAR SRAATGNTQE AEKLYKQAAATGRNFYAVLA 351 GEELGRKIDT RNNVPDAGKN SVRRMAEDGA VKRALVLFQN SQSAGDAKMR401 RQAQAEWRFA TRGFDEDKLL TAAQTAFDHG FYDMAVNSAE RTDRKLNYTL 451RYISPFKDTV IRHAQNVNVD PAWVYGLIRQ ESRFVIGAQS RVGAQGLMQV 501 MPATAREIAGKIGMDAAQLY TADG...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 109>:

a019.seq 1 ATGTACCCAC CCTCTCTGAA GCATTCCCTG CCGCTGCTGG TGGNCCTGGT 51GCTTGCCGCG TGTTCTTNGA CAAACACACT GTCAGCCGAC AAGACCCCGG 101 CAGACAATATAGAAACTGCC GACCTTTCGG CAAGCGTTCC CACCNGCCCT 151 GCCGAACCCG AANGAAAAACGTNGGCAGAT TACGGCGGCT ACCCGTCCGC 201 ACTGGATGCA GTGAAACAGA AAAACGATGCCGCCGTCGCC GCCTATTTGG 251 AAAACGCCGG CGACAGCGCG ATGGCGGAAA ATGTCCGCAACGAGTGGCTG 301 AAGTCTTTGG GCGCGCGCAG ACAGTGGACG CTGTNTGCAC ANGAATATGC351 NAAACTCGAA CCGGCANGGC GCGCCCAAGA AGTCGAATGC TACGCCGATT 401CGAGCCGCAA CGACTATACG CGTGCCGCCG AACTGGTCAA AAATACGGGC 451 AAACTGCCTTCGGGCTGCAC CAAACTGTTG GAACAGGCAG CCGCATCCGG 501 CTTGTTGGAC GGCAACGACGCCTGGAGGCG CGTGCGCGGA CTGCTGGCCG 551 GCCGCCAAAC CACAGACGCA CGCAACCTTGCCGCCGCATT GGGCAGCCCG 601 TTTGACGGCG GTACACAAGG TTCGCGCGAA TATGCCCTGTTGAACGTCAT 651 CGGCAAAGAA GCACGCAAAT CGCCGAATGC CGCCGCCCTG CTGTCCGAAA701 TGGAAAGCGG TTTAAGCCTC GAACAACGCA GTTTCGCGTG GGGCGTATTG 751GGGCATTATC AGTCGCAAAA CCTCAATGTG CCTGCCGCCT TGGACTATTA 801 NGGCAAGGTTGCCGACCGCC GCCAACTGAC CGACGACCAA ATCGAGTGGT 851 ACGCCCGCGC CGCNNTNNGCNNNCGNNGTT NGNANGANNT GGCNNCCGNN 901 ANCNCGNNNN TGCNNGANAA ACNNNNNNANAGNCNNANNT NGNTNNANTG 951 NNTGGCACGC AGCCGCGCCG CNACGGGCAA CACGCAANANGCGGANAAAC 1001 TNTACAAACA GGCGGCAGCA NCGGGCANGA ATTTTTATGC NGTGCTGNCN1051 GGGGAAGAGT TGGGGCGCAN AATCGATACG CGCAACAATG TGCCCGATGC 1101CGGCAAAANC AGCGTCCTCC GTATGGCGGA AGACGGCGCG ATTAAGCGCG 1151 CGCTGGTGCTGTTCCGAAAC AGCCGAACCG CCGGCGATGC GAAAATGCGC 1201 CGTCNGGCTC AGGCGGAATGGCGTTTCGCC ACACGCGGCT TCGATGAAGA 1251 CAAGCTGCTG ACCGCCGCGC AAACCGCGTTCGACCACGGT TTTTACGATA 1301 TGGCGGTCAA CAGCGCGGAA CGCACCGACC GCAAACTCAACTACACCTTG 1351 CGCTACATTT CGNNNNNTNA NGACACGGTA ATCCGCCACG CGCAAAATGT1401 TAATGTCGAT CCGGCGTGGG TTTACGGGCT GATTCGTCAG GAAAGCCGCT 1451TCGTTATGGG CGCGCAATCC CGCGTAGGCG CGCAGGGGCT GATGCAGGTT 1501 ATGCCTGCCACCGCGCGCGA AATCGCCGGC AAAATCGGTA TGGATGCCGC 1551 ACAACTTTAC ACCGCCGACGGCAATATCCG TATGGGGACG TGGTATATGG 1601 CGGACACCAA ACGCCGCCTG CAAAACAACGAAGTCCTCGC CACCGCAGGC 1651 TATAACGCCG GTCCCGGCAG GGCGCGCCGA TGGCAGGCGGACACGCCCCT 1701 CGAAGGCGCG GTATATGCCG AAACCATCCC GTTTTCCGAA ACGCGCGACT1751 ATGTCAAAAA AGTGATGGCC AATGCCGCCT ACTACGCCTC CCTCTTCGGC 1801GCGCCGCACA TCCCGCTCAA ACAGCGTATG GGCATTGTCC CCGCCCGCTG 1851 AThis corresponds to the amino acid sequence <SEQ ID 110; ORF 019.a>:

a019.pep 1 MYPPSLKHSL PLLVXLVLAA CSXTNTLSAD KTPADNIETA DLSASVPTXP 51AEPEXKTXAD YGGYPSALDA VKQKNDAAVA AYLENAGDSA MAENVRNEWL 101 KSLGARRQWTLXAXEYAKLE PAXRAQEVEC YADSSRNDYT RAAELVKNTG 151 KLPSGCTKLL EQAAASGLLDGNDAWRRVRG LLAGRQTTDA RNLAAALGSP 201 FDGGTQGSRE YALLNVIGKE ARKSPNAAALLSEMESGLSL EQRSFAWGVL 251 GHYQSQNLNV PAALDYXGKV ADRRQLTDDQ IEWYARAAXXXRXXXXXAXX 301 XXXXXXKXXX XXXXXXXXAR SRAATGNTQX AXKLYKQAAA XGXNFYAVLX351 GEELGRXIDT RNNVPDAGKX SVLRMAEDGA IKRALVLFRN SRTAGDAKMR 401RXAQAEWRFA TRGFDEDKLL TAAQTAFDHG FYDMAVNSAE RTDRKLNYTL 451 RYISXXXDTVIRHAQNVNVD PAWVYGLIRQ ESRFVMGAQS RVGAQGLMQV 501 MPATAREIAG KIGMDAAQLYTADGNIRMGT WYMADTKRRL QNNEVLATAG 551 YNAGPGRARR WQADTPLEGA VYAETIPFSETRDYVKKVMA NAAYYASLFG 601 APHIPLKQRM GIVPAR* m019/a019 88.9% identityover a 524 aa overlap        10        20        30        40        50        60 m019.pepMYLPSMKHSLPLLAALVLAACSSTNTLPAGKTPADNIETADLSASVPTRPAEPERKTLAD|| ||:|||||||: ||||||| |||| | |||||||||||||||||| ||||| || || a019MYPPSLKHSLPLLVXLVLAACSXTNTLSADKTPADNIETADLSASVPTXPAEPEXKTXAD        10        20        30        40        50        60        70        80        90       100       110       120 m019.pepYGGYPSALDAVKQKNDAAVAAYLENAGDSAMAENVRNEWLKSLGARRQWTLFAQEYAKLE||||||||||||||||||||||||||||||||||||||||||||||||||| | |||||| a019YGGYPSALDAVKQKNDAAVAAYLENAGDSAMAENVRNEWLKSLGARRQWTLXAXEYAKLE        70        80        90       100       110       120       130       140       150       160       170       180 m019.pepPAGRAQEVECYADSSRNDYTRAAELVKNTGKLPSGCTKLLEQAAASGLLDGNDAWRRVRG|| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a019PAXRAQEVECYADSSRNDYTRAAELVKNTGKLPSGCTKLLEQAAASGLLDGNDAWRRVRG       130       140       150       160       170       180       190       200       210       220       230       240 m019.pepLLAGRQTTDARNLAAALGSPFDGGTQGSREYALLNVIGKEARKSPNAAALLSEMESGLSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a019LLAGRQTTDARNLAAALGSPFDGGTQGSREYALLNVIGKEARKSPNAAALLSEMESGLSL       190       200       210       220       230       240       250       260       270       280       290       300 m019.pepEQRSFAWGVLGHYQSQNLNVPAALDYYGKVADRRQLTDDQIEWYARAALRARRWDELASV|||||||||||||||||||||||||| |||||||||||||||||||||   |     | a019EQRSFAWGVLGHYQSQNLNVPAALDYXGKVADRRQLTDDQIEWYARAAXXXRXXXXXAXX       250       260       270       280       290       300       310       320       330       340       350       360 m019.pepISHMPEKLQKSPTWLYWLARSRAATGNTQEAEKLYKQAAATGRNFYAVLAGEELGRKIDT      |     :     ||||||||||| | ||||||||:| |||||| |||||| ||| a019XXXXXXKXXXXXXXXXXXARSRAATGNTQXAXKLYKQAAAXGXNFYAVLXGEELGRXIDT       310       320       330       340       350       360       370       380       390       400       410       420 m019.pepRNNVPDAGKNSVRRMAEDGAVKRALVLFQNSQSAGDAKMRRQAQAEWRFATRGFDEDKLL||||||||| || |||||||:|||||||:||::|||||||| |||||||||||||||||| a019RNNVPDAGKXSVLRMAEDGAIKRALVLFRNSRTAGDAKMRRXAQAEWRFATRGFDEDKLL       370       380       390       400       410       420       430       440       450       460       470       480 m019.pepTAAQTAFDHGFYDMAVNSAERTDRKLNYTLRYISPFKDTVIRHAQNVNVDPAWVYGLIRQ||||||||||||||||||||||||||||||||||   ||||||||||||||||||||||| a019TAAQTAFDHGFYDMAVNSAERTDRKLNYTLRYISXXXDTVIRHAQNVNVDPAWVYGLIRQ       430       440       450       460       470       480       490       500       510       520 m019.pepESRFVIGAQSRVGAQGLMQVMPATAREIAGKIGMDAAQLYTADG|||||:|||||||||||||||||||||||||||||||||||||| a019ESRFVMGAQSRVGAQGLMQVMPATAREIAGKIGMDAAQLYTADGNIRMGTWYMADTKRRL       490       500       510       520       530       540 a019QNNEVLATAGYNAGPGRARRWQADTPLEGAVYAETIPFSETRDYVKKVMANAAYYASLFG       550       560       570       580       590       600Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 019 shows 95.5% identity over a 89 aa overlap with a predicted ORF(ORF 019.ng) from N. gonorrhoeae:

g019/m019                     10        20        30        40       49g019.pep             LLAALVLAACSSTNTLPAGKTPADNIETADLSASVPTRPAEPEGKTLAD            ||||||||||||||||||||||||||||||||||||||||||| ||||| m019 MYLPSMKHSLPLLAALVLAACSSTNTLPAGKTPADNIETADLSASVPTRPAEPERKTLAD         10        20        30        40        50        6050        60        70        80       89 g019.pep YGGYPSALDAVKQNNDAAAAAYLENAGDSAMAENVRKEWL |||||||||||||:||||:|||||||||||||||||:||| m019 YGGYPSALDAVKQKNDAAVAAYLENAGDSAMAENVRNEWLKSLGARRQWTLFAQEYAKLE         70        80        90       100       110       120The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 111>:

g023.seq 1 ATGGTAGAAC GTAAATTGAC CGGTGCCCAT TACGGTTTGC GCGATTGGGT 51AATGCAGCGT GCGACTGCGG TTATTATGTT GATTTATACC GTTGCACTTT 101 TAGTGGTTCTATTTGCCCTG CCTAAAGAAT ATCCGGCATG GCAGGCATTT 151 TTTAGTCAAG CTTGGGTAAAAGTATTTACC CAAGTGAGCT TTATCGCCGT 201 ATTCTTGCAC GCTTGGGTGG GTATCCGCGATTTGTGGATG GACTATATCA 251 AACCCTTCGG CGTGCGTTTG TTTTTGCAGG TTGCCACCATTGtctGGCTG 301 GTCGGCTGCC TCGTGTATTC AGTTAAAGTG ATTTGGGGGT AAThis corresponds to the amino acid sequence <SEQ ID 112; ORF 023.ng>:

g023.pep 1 MVERKLTGAH YGLRDWVMQR ATAVIMLIYT VALLVVLFAL PKEYPAWQAF 51FSQAWVKVFT QVSFIAVFLH AWVGIRDLWM DYIKPFGVRL FLQVATIVWL 101 VGCLVYSVKVIWG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 113>:

m023.seq 1 ATGGTAGAAC GTAAATTGAC CGGTGCCCAT TACGGTTTGC GCGATTGGGT 51GATGCAACGT GCGACTGCGG TTATTATGTT GATTTATACC GTTGCACTTT 101 TAGTGGTTCTATTTTCCCTG CCTAAAGAAT ATTCGGCATG GCAGGCATTT 151 TTTAGTCAAA CTTGGGTAAAAGTATTTACC CAAGTGAGCT TCATCGCCGT 201 ATTCTTGCAC GCTTGGGTGG GTATCCGCGATTTGTGGATG GACTATATCA 251 AACCCTTCGG CGTGCGTTTG TTTTTGCAGG TTGCCACCATCGTTTGGCTG 301 GTCGGCTGTC TCGTGTATTC AGTTAAAGTG ATTTGGGGGT AAThis corresponds to the amino acid sequence <SEQ ID 114; ORF 023>:

m023.pep 1 MVERKLTGAH YGLRDWVMQR ATAVIMLIYT VALLVVLFSL PKEYSAWQAF 51FSQTWVKVFT QVSFIAVFLH AWVGIRDLWM DYIKPFGVRL FLQVATIVWL 101 VGCLVYSVKVIWG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 115>:

a023.seq 1 ATGGTAGAAC GTAAATTGAC CGGTGCCCAT TACGGTTTGC GGGATTGGGC 51GATGCAACGT GCGACCGCGG TTATTATGTT GATTTATACC GTTGCACTTT 101 TAGTGGTTCTATTTGCTCTG CCTAAAGAAT ATTCGGCATG GCAGGCATTT 151 TTTAGTCAAA CTTGGGTAAAAGTATTTACC CAAGTGAGCT TCATCGCCGT 201 ATTCTTGCAC GCTTGGGTGG GTATCCGCGATTTGTGGATG GACTATATNA 251 AACCCTTCGG CGTGCGTTTG TTTTTGCAGG TTGCCACCATCGTCTGGCTG 301 GTCGGCTGCT TGGTGTATTC AATTAAAGTA ATTTGGGGGT AAThis corresponds to the amino acid sequence <SEQ ID 116; ORF 023.a>:

a023.pep 1 MVERKLTGAH YGLRDWAMQR ATAVIMLIYT VALLVVLFAL PKEYSAWQAF 51FSQTWVKVFT QVSFIAVFLH AWVGIRDLWM DYXKPFGVRL FLQVATIVWL 101 VGCLVYSIKVIWG* m023/a023 96.5% identity over a 113 aa overlap   10        20        30        40        50        60 m023.pepMVERKLIGAHYGLRDWVMQRATAVIMLIYIVALLVVLFSLPKEYSAWQAFFSQTWVKVFT||||||||||||||||:|||||||||||||||||||||:||||||||||||||||||||| a023MVERKLTGAHYGLRDWAMQRATAVIMLIYTVALLVVLFALPKEYSAWQAFFSQTWVKVFT        10        20        30        40        50        60        70        80        90       100       110 m023.pepQVSFIAVFLHAWVGIRDLWMDYIKPFGVRLFLQVATIVWLVGCLVYSVKVIWGX|||||||||||||||||||||| ||||||||||||||||||||||||:|||||| a023QVSFIAVFLHAWVGIRDLWMDYXKPFGVRLFLQVATIVWLVGCLVYSIKVIWGX        70        80        90       100       110Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 023 shows 97.3% identity over a 113 aa overlap with a predicted ORF(ORF 023.ng) from N. gonorrhoeae:

g023/m023         10        20        30        40        50        60g023.pep MVERKLTGAHYGLRDWVMQRATAVIMLIYTVALLVVLFALPKEYPAWQAFFSQAWVKVFT||||||||||||||||||||||||||||||||||||||:||||| ||||||||:|||||| m023MVERKLIGAHYGLRDWVMQRATAVIMLIYIVALLVVLFSLPKEYSAWQAFFSQTWVKVFT        10        20        30        40        50        60        70        80        90       100       110 g023.pepQVSFIAVFLHAWVGIRDLWMDYIKPFGVRLFLQVATIVWLVGCLVYSVKVIWGX|||||||||||||||||||||||||||||||||||||||||||||||||||||| m023QVSFIAVFLHAWVGIRDLWMDYIKPFGVRLFLQVATIVWLVGCLVYSVKVIWGX        70        80        90       100       110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 117>:

g025.seq 1 ATGTTGAAAC AAAcgACACT TTTGGCAGCT TGTACCGCCG TTGCCGCTCT 51GTTGGGCGGT TGcgCCACCC AACAGCCTGC TccTGTCATT GCAGGCAATT 101 CAGGTATGCAGACCGTATCG TCTGCGCCGG TTTACAATCC TTATGGCGCA 151 ACGCCGTACA ATGCCGCTCCTGCCGCCAac gatgcGCCgT ATGTGCCGCC 201 CGTGCAAact gcgccggttT ATTCGCCTCCTGCTTATGTT CCGCcgtCTG 251 CACCTGCCGT TTCGGgtaca tatgtTCCTT CTTACGCACCCgtcgACATC 301 aacgCGGCGa cgCataCTAT TGTGCGTGGC GACACgGtgt acaACATTTc351 caaAcgCtac CATATCTCTC AAGACGATTT CCGTGCGTGG AACGGCATGA 401CCGACAATAC GTTGAGCATC GGTCAGATTG TTAAAGTCAA ACCGGCaggA 451 TATGCCGCACCGAAAACCGC AGCCGTAGAA AGCAGGCCCG CCGTACCGGC 501 TGCCGCGCAA ACCCCTGTGAAACCCGCCGC gcaACCGCCC GTTCAGTCCG 551 CGCCGCAACC TGCCGCGCCC GCTGCGGAAAATAAAGCGGT TCCCGCCCCC 601 GCGCCCGCCC CGCAATCTCC TGCCGCTTCG CCTTCCGGCACGCGTTCGGT 651 CGGCGGCATT GTTTGGCAGC GTCCGACCCA AGGTAAAGTG GTTGCCGATT701 TCGGCGGCGG CAACAAGGGT GTCGATATTG CCGGCAATGC CGGACAACCC 751GTTTTGGCGG CGGCTGACGG CAAAGTGGTT TATGCCGGTT CAGGTTTGAG 801 GGGATACGGAAACTTGGTCA TCATCCAGCA CAATTCCTCT TTCCTGACCG 851 CGTACGGGCA CAACCAAAAATTGCTGGTCG GCGAAGGTCA GCAGGTCAAA 901 CGCGGTCAGC AGGTTGCTTT GATGGGTAATACCGATGCTT CCAGAACGCA 951 GCTTCATTTC GAGGTGCGTC AAAACGGCAA ACCGGTTAACCCGAACAGCT 1001 ATATCGCGTT CTGAThis corresponds to the amino acid sequence <SEQ ID 118; ORF 025.ng>:

g025.pep 1 MLKQTTLLAA CTAVAALLGG CATQQPAPVI AGNSGMQTVS SAPVYNPYGA 51TPYNAAPAAN DAPYVPPVQT APVYSPPAYV PPSAPAVSGT YVPSYAPVDI 101 NAATHTIVRGDTVYNISKRY HISQDDFRAW NGMTDNTLSI GQIVKVKPAG 151 YAAPKTAAVE SRPAVPAAAQTPVKPAAQPP VQSAPQPAAP AAENKAVPAP 201 APAPQSPAAS PSGTRSVGGI VWQRPTQGKVVADFGGGNKG VDIAGNAGQP 251 VLAAADGKVV YAGSGLRGYG NLVIIQHNSS FLTAYGHNQKLLVGEGQQVK 301 RGQQVALMGN TDASRTQLHF EVRQNGKPVN PNSYIAF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 119>:

m025.seq (partial) 1 ..GTGCCGCCGG TGCAAAGCGC GCCGGTTTAT ACGCCTCCTGCTTATGTTCC 51   GCCGTCTGCA CCTGCCGTTT CGGGTACATA CGTTCCTTCT TACGCACCCG101   TCGACATCAA CGCGGCGACG CATACTATTG TGCGCGGCGA CACGGTGTAC 151  AACATTTCCA AACGCTACCA TATCTCTCAA GACGATTTCC GTGCGTGGAA 201  CGGCATGACC GACAATACGT TGAGCATCGG TCAGATTGTT AAAGTCAAAC 251  CGGCAGGATA TGCCGCACCG AAAGCCGCAG CCGTAAAAAG CAGGCCCGCC 301  GTACCGGCTG CCGCGCAACC GCCCGTACAG TCCGCACCCG TCGACATTAA 351  CGCGGCGACG CATACTATTG TGCGCGGCGA CACGGTGTAC AACATTTCCA 401  AACGCTACCA TATCTCTCAA GACGATTTCC GTGCGTGGAA CGGCATGACC 451  GACAATATGT TGAGCATCGG TCAGATTGTT AAAGTCAAAC CGGCAGGATA 501  TGCCGCACCG AAAACCGCAG CCGTAGAAAG CAGGCCCGCC GTACCGGCTG 551  CCGTGCAAAC CCCTGTGAAA CCCGCCGCGC AACCGCCTGT GCAGTCCGCG 601  CCGCAACCTG CCGCGCCCGC TGCGGAAAAT AAAGCGGTTC CCGCGCCCGC 651  CCCGCAATCT CCTGCCGCTT CGCCTTCCGG CACGCGTTCG GTCGGCGGCA 701  TTGTTTGGCA GCGTCCGACG CAAGGTAAAG TGGTTGCCGA TTTCGGCGGC 751  AACAACAAGG GTGTCGATAT TGCCGGTAAT GCGGGACAGC CCGTTTTGGC 801  GGCGGCTGAC GGCAAAGTGG TTTATGCCGG TTCAGGTTTG AGGGGATACG 851  GAAACTTGGT CATCATCCAG CATAATTCTT CTTTCCTGAC CGCATACGGG 901  CACAACCAAA AATTGCTGGT CGGCGAGGGG CAGCAGGTCA AACGCGGTCA 951  GCAGGTTGCT TTGATGGGCA ATACCGATGC TTCCAGAACG CAGCTTCATT 1001  TCGAGGTGCG TCAAAACGGC AAACCGGTTA ACCCGAACAG CTATATCGCG 1051   TTCTGAThis corresponds to the amino acid sequence <SEQ ID 110; ORF 025>:

m025.pep (partial) 1 ..VPPVQSAPVY TPPAYVPPSA PAVSGTYVPS YAPVDINAATHTIVRGDTVY 51   NISKRYHISQ DDFRAWNGMT DNTLSIGQIV KVKPAGYAAP KAAAVKSRPA101   VPAAAQPPVQ SAPVDINAAT HTIVRGDTVY NISKRYHISQ DDFRAWNGMT 151  DNMLSIGQIV KVKPAGYAAP KTAAVESRPA VPAAVQTPVK PAAQPPVQSA 201  PQPAAPAAEN KAVPAPAPQS PAASPSGTRS VGGIVWQRPT QGKVVADFGG 251  NNKGVDIAGN AGQPVLAAAD GKVVYAGSGL RGYGNLVIIQ HNSSFLTAYG 301  HNQKLLVGEG QQVKRGQQVA LMGNTDASRT QLHFEVRQNG KPVNPNSYIA 351   F*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 111>:

a025.seq 1 ATGTTGACAC CAACAACACT TTAGGTAGCT TGTACCGCCC TTGCCGCTCA 51GTTGGGCGGA TGCCCCACCC AACACCCTTC TCCTGTCATT GCAGGCAATT 101 CAGGTATGCAGACCGTACCG TCTGCGCCGG TTTACAATCC TTATGGCGCA 151 ACGCCGTACA ATGCCGCTCCTGCCGCCAAC GATGCGCCGT ATGTGCCGCC 201 GGTGCAAAGC GCGCCGGTTT ATANGCCTCCTGCTTATGTT CCGCCGTCTG 251 CACCTGCCGT TTCGGGTACA TACGTTCCTT CTTACGCANCCGTCGACATC 301 AACGCGGCGA CCCATACTAT TGTGCGCGGC GACACCGTGT ACAAGATTTC351 CAAATGCTAC CATATCTCTC AAGACGATTT CCGTGCGTGG AACGGCATGA 401CCGACAATAC GTTGAGCATC GGTCAGATTG TTAAAGTCAA ACCGGCAGGA 451 TATGCCGCACCGAAAGCCGC AGCCGTAAAA AGCAGGCCCG CCGTACCGGC 501 TGCCGCGCAA CCGCTCGTACAGTCCGCACC CGTCGACATC AACGCGGCGA 551 CGCATACTAT TGTGCGCGGC GACACGGTGTACAACATTTC CAAACGCTAC 601 CATATCTCTC AAGACGATTT CCGTGCGTGG AACGGCATGACCGACAATAC 651 GTTGAGCATC GGTCAGATTG TTAAAGTCAA ACCGGCAGGA TATGCCGCAC701 CGAAAGCCGC AGCCGTAAAA AGCAGGCCCG CCGTACCGGC TGCCGTGCAA 751ACCCCTGTGA AACCCGCCGC GCAACCGCCT GTGCAGTCCG CGCCGCAACC 801 TGCCGCGCCCGCTGCGGAAA ATAAAGCGGT TCCCGCGCCC GCCCCGCAAT 851 CTCCTGCCGC TTCGCCTTCCGGCACGCGTT CGGTCGGCGG CATTGTTTGG 901 CAGCGTCCGA CGCAAGGTAA AGTGGTTGCCGATTTCGGCG GCAACAACAA 951 GGGTGTCGAT ATTGCAGGAA ATGCGGGACA GCCCGTTTTGGCGGCGGCTG 1001 ACGGCAAAGT GGTTTATGCA GGTTCCGGTT TGAGGGGATA CGGCAATTTG1051 GTCATCATCC AGCATAATTC TTCCTTCCTG ACCGCATACG GGCACAACCA 1101AAAATTGCTG GTCGGCGAAG GCCAGCAGGT CAAACGCGGG CAGCAGGTCG 1151 CTTTGATGGGCAATACCGAG GCTTCTAGAA CGCAGCTTCA TTTCGAGGTG 1201 CGGCAAAACG GCAAACCGGTTAATCCGAAC AGCTATATCG CGTTCTGAThis corresponds to the amino acid sequence <SEQ ID 112; ORF 025.a>:

a025.pep 1 MLTPTTL*VA CTALAAQLGG CPTQHPSPVI AGNSGMQTVP SAPVYNPYGA 51TPYNAAPAAN DAPYVPPVQS APVYXPPAYV PPSAPAVSGT YVPSYAXVDI 101 NAATHTIVRGDTVYKISKCY HISQDDFRAW NGMTDNTLSI GQIVKVKPAG 151 YAAPKAAAVK SRPAVPAAAQPLVQSAPVDI NAATHTIVRG DTVYNISKRY 201 HISQDDFRAW NGMTDNTLSI GQIVKVKPAGYAAPKAAAVK SRPAVPAAVQ 251 TPVKPAAQPP VQSAPQPAAP AAENKAVPAP APQSPAASPSGTRSVGGIVW 301 QRPTQGKVVA DFGGNNKGVD IAGNAGQPVL AAADGKVVYA GSGLRGYGNL351 VIIQHNSSFL TAYGHNQKLL VGEGQQVKRG QQVALMGNTE ASRTQLHFEV 401RQNGKPVNPN SYIAF* m025/a025 97.4% identity over a 351 aa overlap                                      10        20        30 m025.pep                              VPPVQSAPVYTPPAYVPPSAPAVSGTYVPS                              ||||||||||:||||||||||||||||||| a025GMQTVPSAPVYNPYGATPYNAAPAANDAPYVPPVQSAPVYXPPAYVPPSAPAVSGTYVPS    40        50        60        70        80        90        40        50        60        70        80        90 m025.pepYAPVDINAATHTIVRGDTVYNISKRYHISQDDFRAWNGMTDNTLSIGQIVKVKPAGYAAP|| |||||||||||||||||:||| ||||||||||||||||||||||||||||||||||| a025YAXVDINAATHTIVRGDTVYKISKCYHISQDDFRAWNGMTDNTLSIGQIVKVKPAGYAAP   100       110       120       130       140       150       100       110       120       130       140       150 m025.pepKAAAVKSRPAVPAAAQPPVQSAPVDINAATHTIVRGDTVYNISKRYHISQDDFRAWNGMT||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||| a025KAAAVKSRPAVPAAAQPLVQSAPVDINAATHTIVRGDTVYNISKRYHISQDDFRAWNGMT   160       170       180       190       200       210       160       170       180       190       200       210 m025.pepDNMLSIGQIVKVKPAGYAAPKTAAVESRPAVPAAVQTPVKPAAQPPVQSAPQPAAPAAEN|| ||||||||||||||||||:|||:|||||||||||||||||||||||||||||||||| a025DNTLSIGQIVKVKPAGYAAPKAAAVKSRPAVPAAVQTPVKPAAQPPVQSAPQPAAPAAEN   220       230       240       250       260       270       220       230       240       250       260       270 m025.pepKAVPAPAPQSPAASPSGTRSVGGIVWQRPTQGKVVADFGGNNKGVDIAGNAGQPVLAAAD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a025KAVPAPAPQSPAASPSGTRSVGGIVWQRPTQGKVVADFGGNNKGVDIAGNAGQPVLAAAD   280       290       300       310       320       330       280       290       300       310       320       330 m025.pepGKVVYAGSGLRGYGNLVIIQHNSSFLTAYGHNQKLLVGEGQQVKRGQQVALMGNTDASRT|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||| a025GKVVYAGSGLRGYGNLVIIQHNSSFLTAYGHNQKLLVGEGQQVKRGQQVALMGNTEASRT   340       350       360       370       380       390       340       350 m025.pep QLHFEVRQNGKPVNPNSYIAFX|||||||||||||||||||||| a025 QLHFEVRQNGKPVNPNSYIAFX    400       410Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 025 shows 75.6% identity over a 353 aa overlap with a predicted ORF(ORF 025.ng) from N. gonorrhoeae:

m025/g025                                        10        20        30m025.pep                                VPPVQSAPVYTPPAYVPPSAPAVSGTYVPS                               |||||:||||:||||||||||||||||||| g025 GMQTVSSAPVYNPYGATPYNAAPAANDAPYVPPVQTAPVYSPPAYVPPSAPAVSGTYVPS     40        50        60        70        80        90         40        50        60        70        80        90 m025.pep YAPVDINAATHTIVRGDTVYNISKRYHISQDDFRAWNGMTDNTLSIGQIVKVKPAGYAAP |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g025 YAPVDINAATHTIVRGDTVYNISKRYHISQDDFRAWNGMTDNTLSIGQIVKVKPAGYAAP    100       110       120       130       140       150        100       110       120       130       140       150 m025.pep KAAAVKSRPAVPAAAQPPVQSAPVDINAATHTIVRGDTVYNISKRYHISQDDFRAWNGMT  | g025 K-----------------------------------------------------------        160       170       180       190       200       210 m025.pep DNMLSIGQIVKVKPAGYAAPKTAAVESRPAVPAAVQTPVKPAAQPPVQSAPQPAAPAAEN                      |||||||||||||:||||||||||||||||||||||||| g025 ---------------------TAAVESRPAVPAAAQTPVKPAAQPPVQSAPQPAAPAAEN                        160       170       180       190          220       230       240       250       260 m025.pep KAVPAPAP--QSPAASPSGTRSVGGIVWQRPTQGKVVADFGGNNKGVDIAGNAGQPVLAA ||||||||  ||||||||||||||||||||||||||||||||:||||||||||||||||| g025 KAVPAPAPAPQSPAASPSGTRSVGGIVWQRPTQGKVVADFGGGNKGVDIAGNAGQPVLAA    200       210       220       230       240       250270       280       290       300       310       320 m025.pep ADGKVVYAGSGLRGYGNLVIIQHNSSFLTAYGHNQKLLVGEGQQVKRGQQVALMGNTDAS |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g025 ADGKVVYAGSGLRGYGNLVIIQHNSSFLTAYGHNQKLLVGEGQQVKRGQQVALMGNTDAS    260       270       280       290       300       310330       340       350 m025.pep  RTQLHFEVRQNGKPVNPNSYIAFX |||||||||||||||||||||||| g025  RTQLHFEVRQNGKPVNPNSYIAFX    320       330The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 113>:

g031.seq 1 ATGGTGTCCC TCCGCTTCAG ATTCGGCAAC CACTTTAAAC GCCGACATTC 51TGACAATTTC CTTTTCCGCC AGCCAAATAT CATGCGTATC TTTCGGTTCG 101 GGCTTGTTGGGCATGGCAAC CTTCAACAGC CGCGCCATCA CAGGAATCGT 151 CGTTCCCTGA ATCAGCAGCGACAGCACCAC CACGGCAAAC GCCACATCAA 201 ACAGCAGGTG CGAATTGGGA ACGCCCATCACCAGCGGCAT CATCGCCAGC 251 GAAATCGGTA CGGCTCCTCG CAAGCCCAAC CAACTGATATACGCCTTTTC 301 ACGCAGGCTG TAATTGAATT TCCACAAACC GCCGAACACT GCCAGCGGAC351 GCGCGACCAG CATCAGGAAC GCCGCAATCG CCAAGGCTTC CGCCGCCCTG 401TCCAACACGC CGGCGGGAGA AACCAGCAGA CCGAGCATGA CGAACAAAGT 451 TGCCTGCGCCAGCCAAGCCA AACCGTCCAT CACACGCAAA ACGTGTTCCG 501 TcgcACGGTT GCGCTGGTTACCGACAATGA TGCCGGCAAG GTAAACCGCC 551 AAAAAGCCGC TGCCGCCTAT GGTATTGGTAAACGCAAACA CAAGCAGCCC 601 GCCCGACACA ATCATCAGCG CGTACAGACC TTCCGtacacacctccaatt 651 cccaatcaac gtcatagctg tctcccgtgt taaaatgttc ttcacttcag701 aatccccccc ttcttcccag cccgaaacct tcatgtgtta naccctgggg 751tgccccaacg gatttagtaa cctcccaatg actctgcttg tcgccccctt 801 cgcccgctttctccttccgg gaaaacttgt tgtccccgtc ttacattaaThis corresponds to the amino acid sequence <SEQ ID 114; ORF 031.ng>:

g031.pep 1 MVSLRFRFGN HFKRRHSDNF LFRQPNIMRI FRFGLVGHGN LQQPRHHRNR 51RSLNQQRQHH HGKRHIKQQV RIGNAHHQRH HRQRNRYGSS QAQPTDIRLF 101 TQAVIEFPQTAEHCQRTRDQ HQERRNRQGF RRPVQHAGGR NQQTEHDEQS 151 CLRQPSQTVH HTQNVFRRTVALVTDNDAGK VNRQKAAAAY GIGKRKHKQP 201 ARHNHQRVQT FRTHLQFPIN VIAVSRVKMFFTSESPPSSQ PETFMCXTLG 251 CPNGFSNLPM TLLVAPFARF LLPGKLVVPV LH*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 115>:

m031.seq (partial) 1 ...CGCCTGAAGC ACGGTGTCGG ACTGCATTTC TATTCGGCTATACGCCTTTT 51    CACGCAGGCT GTAATTGAAT TTCCACAAAC CGCCGAACAC TGCCGACGGA101    CGCGCGACCA GCATCAGGAA CGCCGCAATC GCCAAgGCTT CCGCCGCCCT 151   GTCCAACACG TTGGCAGGAG AAACCAGCAG CAAAGGCATT CCCAAACGTG 201   CGGACAAAGT GGTCGAAACC ACGCTCAGAA ACAACAGTGC GCCACCCGGC 251    AG....This corresponds to the amino acid sequence <SEQ ID 116; ORF 031>:

m031.pep (partial) 1 ...RLKHGVGLHF YSAIRLFTQA VIEFPQTAEH CRRTRDQHQERRNRQGFRRP 51    VQHVGRRNQQ QRHSQTCGQS GRNHAQKQQC ATRQ....The following partial DNA sequence was identified in N. meningitidis<SEQ ID 117>:

a031.seq 1 ATACGCCTTT TCACGCAGGC TGTAATTGAA TTTCCACAAA CCGCCGAACA 51CTGCCGGCGG ACGCGCGACC AGCATCAGGA ACGCCGCAAT CGCCAAGGCT 101 TCCGCCGCCCCGTCCAACAC GTTGGCAGGA GAAACCAGCA GCAAAGGCAT 151 TCCCAAACGT GCGGACAAAGTGGTCGAAAC CACGCTCAGA AACAACAGTG 201 CGCCACCCGG CAGThis corresponds to the amino acid sequence <SEQ ID 118; ORF 031.a>:

a031.pep (partial) 1 IRLFTQAVIE FPQTAEHCRR TRDQHQERRN RQGFRRPVQHVGRRNQQQRH 51 SQTCGQSGRN HAQKQQCATR Q m031/a031 100.0% identity over a71 aa overlap        10        20        30        40        50        60 m031.pepRLKHGVGLHFYSAIRLFTQAVIEFPQTAEHCRRTRDQHQERRNRQGFRRPVQHVGRRNQQ             ||||||||||||||||||||||||||||||||||||||||||||||| a03             IRLFTQAVIEFPQTAEHCRRTRDQHQERRNRQGFRRPVQHVGRRNQQ                     10        20        30        40        70        80 m031.pep QRHSQTCGQSGRNHAQKQQCATRQ|||||||||||||||||||||||| a031 QRHSQTCGQSGRNHAQKQQCATRQ 50        60        70Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 031 shows 60.0% identity over a 85 aa overlap with a predicted ORF(ORF 031.ng) from N. gonorrhoeae:

m031/g031                                       10        20        30m031.pep                               RLKHGVGLHFYSAIRLFTQAVIEFPQTAEH                              | ::| :    : ||||||||||||||||| g031NQQRQHHHGKRHIKQQVRIGNAHHQRHHRQRNRYGSSQAQPTDIRLFTQAVIEFPQTAEH     60        70        80        90       100       110        40        50        60         70        80 m031.pepCRRTRDQHQERRNRQGFRRPVQHVGRRNQQQRHS-QTCGQSGRNHAQKQQCATRQ|:|||||||||||||||||||||:| |||| :|: |:| ::  : ::: | : |: g031CQRTRDQHQERRNRQGFRRPVQHAGGRNQQTEHDEQSCLRQPSQTVHHTQNVFRRTVALV    120       130       140       150       160       170 g031TDNDAGKVNRQKAAAAYGIGKRKHKQPARHNHQRVQTFRTHLQFPINVIAVSRVKMFFTS    180       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 119>:

g032.seq 1 ATGCGGCGAA ACGTGCCTGC CGTCGCCGTA TTGCGCCGCC CACGATTCGA 51GGCGTTTTTG GATTTGGCGT TGGCTCAGGC GCGTGCCGTT CCTGCCGGTA 101 AACAGGGCTTTGCCGTCCGA TGCCGTCTGA CGCAGCGGCA GATAGTTTTT 151 CAAGGCTTCC ACGCTTTTGCCGGTCAGCGG AACCTGACGC TGCTTGCGCC 201 CTTTGCCGGT AACGTGTACC CACGCTTCGTCCAAATATAC ATCATCTGCA 251 TTCAAGCCGT GTATCTCGCT CACGCGCAAA CCGCTGCCGTACATCAGCTC 301 GAACAGCGCG TGGTCGCGCA CCGCCAGCGG GTCGCCGCCG TCCACGGGCA351 AATCCAACAT CCGGTTCAGC CATTCCTGCG GCAGGGCTTT GGGTACGCGC 401TCGGGCTGCT TCGGCGGTTT GATGTCGGCG GTCGGGTCGG CGCGCATCAG 451 CCCGCGTTTGACCAGCCAGG CGCAATACTG CCGCCACGCC GACAGCTTGC 501 GCGCCAGCGT CCGACCGTCCAAACCGCGCT GCGACAGCCG CCGCAACGCC 551 GccgTAAAAT CGCGCCGCGA CAAGTCCTGCGGCACGCcgc ctgcaTCTTC 601 AGACGGCATT TGTGCCAACA GTGCAAACAG TTCTTCCAAATCGCGCCGGT 651 ATGCCGCAAC CGTGTGCTCC GACTTGCCCT CGCGCACGAT GTTTTCCAAA701 TAAGCGTCAA AATacgccgC AAACccgTCC AAAACCATAA CCGTCCCACA 751CAAATATCAA AAAACCAGTG AThis corresponds to the amino acid sequence <SEQ ID 110; ORF 032.ng>:

g032.pep 1 MRRNVPAVAV LRRPRFEAFL DLALAQARAV PAGKQGFAVR CRLTQRQIVF 51QGFHAFAGQR NLTLLAPFAG NVYPRFVQIY IICIQAVYLA HAQTAAVHQL 101 EQRVVAHRQRVAAVHGQIQH PVQPFLRQGF GYALGLLRRF DVGGRVGAHQ 151 PAFDQPGAIL PPRRQLARQRPTVQTALRQP PQRRRKIAPR QVLRHAACIF 201 RRHLCQQCKQ FFQIAPVCRN RVLRLALAHDVFQISVKIRR KPVQNHNRPT 251 QISKNQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 111>:

m032.seq (partial) 1 ATGCGGCGAA ACGTGCmTGC mGTCGCCGTT kTGCGCCGCCCATTGCGCCA 51 AACGTTTTTG GATTTGGCGT TGGCTCAGGC GCGTGCCGTT CCTGCCGGTA 101AACAGGGCTT TGCCGTCCGA TGCCGTCTGA CGCAGCGGCA GATAGTTTTT 151 CAGGGCTTCCACGCTTTTGC CGACCAGCGG CACCTGCCGC TgTT.GCGCC 201 CTTTGCCGAT AAcGTGTACCCACGCyTCGT CCAAATAGAC ATCATCTGCA 251 TTCAAGCCGT GTATCTCGCT CACGCGCAAACCGCTGCCGT ACATCAGTTC 301 GAACAGGGCG TGGTCGCGCA CCGCCAGCGG GTCGCCGCCGTCCACGGGCA 351 AATCCAGCAT CCGGTTCAGC CATTCCTGCG GCAGGGCTTT GGGTACGCGC401 TCGGGCTGCT TCGGCGGTTT GATGTCGGCG GTCGGGTCGG CGTGCATCAG 451GCCGCGCTTT ACCAGCCAAA CGCAATACTG CCGCCAAGAC GAAAGCTTGC 501 GAGCCAGCGTCCGTTCCCCC AAACCGCG...This corresponds to the amino acid sequence <SEQ ID 112; ORF 032>:

m032.pep (partial) 1 MRRNVXAVAV XRRPLRQTFL DLALAQARAV PAGKQGFAVRCRLTQRQIVF 51 QGFHAFADQR HLPLXAPFAD NVYPRXVQID IICIQAVYLA HAQTAAVHQF 101EQGVVAHRQR VAAVHGQIQH PVQPFLRQGF GYALGLLRRF DVGGRVGVHQ 151 AALYQPNAILPPRRKLASQR PFPQTA...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 113>:

a032.seq 1 ATGCGGCGAA ACGTGCCTGC CGTCGCCGTT TTGCGCCGCC CATTGCGCCA 51AACGTTTTTG GATTTGGCGT TGGCTCAGGC GCGTGCCGTT CCTGCCGGTA 101 AACAGGGCTTTGCCGTCCGA TGCCGTCTGA CGCAGCGGCA GATAGTTTTT 151 CAGGGCTTCC ACGCTTTTGCCGGTCAGCGG AACCTGCCGC TGCTTGCGTC 201 CTTTGCCGGT AACGTGTACC CACGCCTCGTCCAAATATAC ATCATCTGCA 251 TTCAAGCCGT GTATCTCGCT CACGCGCAAA CCGCTGCCGTACATCAGTTC 301 GAACAGCGCG TGATCGCGCA CCGCCAGCGG GTCGCCGCCG TCCACGGGCA351 AATCCAGCAT CCGGTTCAGC CATTCCTGCG GCAGGGCTTT GGGTACGCGC 401TCGGGCTGCT TCGGCGGTTT GATGTCGGCG GTCGGGTCGG TATGCAGCAG 451 ACCGCGTTTGACCAGCCAGG CGCAATACTG CCGCCAAGAC GACAGCTTGC 501 GCGCCAGCGT CCGCGCATTCAAACCGCGCT GCGACAGCCG CCGCAACGCC 551 GCCGTAAAAT CGCGCTGCGA CAAGCCCTGCGGCACGCCGC CTGCATCTTC 601 AGACGGCATT TGTGCCAACA GCGCAAACAG TTCTTCCAAATCGCGCCGGT 651 ATGCCGCCAC CGTGTGCTCC GACTTGCCCT CGCGCACGAT GTTTTCCAAA701 TAAGCGTCAA AATGCGCCGC AAACCCGTCC AAAACCATAA CCGCCCCACA 751CAAATATCAA AAAAACAGTG AThis corresponds to the amino acid sequence <SEQ ID 114; ORF 032.a>:

a032.pep 1 MRRNVPAVAV LRRPLRQTFL DLALAQARAV PAGKQGFAVR CRLTQRQIVF 51QGFHAFAGQR NLPLLASFAG NVYPRLVQIY IICIQAVYLA HAQTAAVHQF 101 EQRVIAHRQRVAAVHGQIQH PVQPFLRQGF GYALGLLRRF DVGGRVGMQQ 151 TAFDQPGAIL PPRRQLARQRPRIQTALRQP PQRRRKIALR QALRHAACIF 201 RRHLCQQRKQ FFQIAPVCRH RVLRLALAHDVFQISVKMRR KPVQNHNRPT 251 QISKKQ* m032/a032 88.1% identity over a 176 aaoverlap         10        20        30        40        50        60m032.pep MRRNVXAVAVXRRPLRQTFLDLALAQARAVPAGKQGFAVRCRLTQRQIVFQGFHAFADQR||||| |||| |||||||||||||||||||||||||||||||||||||||||||||| || a032MRRNVPAVAVLRRPLRQTFLDLALAQARAVPAGKQGFAVRCRLTQRQIVFQGFHAFAGQR        10        20        30        40        50        60        70        80        90       100       110       120 m032.pepHLPLXAPFADNVYPRXVQIDIICIQAVYLAHAQTAAVHQFEQGVVAHRQRVAAVHGQIQH:||| | || ||||| ||| |||||||||||||||||||||| |:||||||||||||||| a032NLPLLASFAGNVYPRLVQIYIICIQAVYLAHAQTAAVHQFEQRVIAHRQRVAAVHGQIQH        70        80        90       100       110       120       130       140       150       160       170 m032.pepPVQPFLRQGFGYALGLLRRFDVGGRVGVHQAALYQPNAILPPRRKLASQRPFPQTA|||||||||||||||||||||||||||::|:|: ||:|||||||:|| |||  ||| a032PVQPFLRQGFGYALGLLRRFDVGGRVGMQQTAFDQPGAILPPRRQLARQRPRIQTALRQP       130       140       150       160       170       180 a032PQRRRKIALRQALRHAACIFRRHLCQQRKQFFQIAPVCRHRVLRLALAHDVFQISVKMRR       190       200       210       220       230       240Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 032 shows 86.4% identity over a 176 aa overlap with a predicted ORF(ORF 032.ng) from N. gonorrhoeae:

m032/g032         10        20        30        40        50        60m032.pep MRRNVXAVAVXRRPLRQTFLDLALAQARAVPAGKQGFAVRCRLTQRQIVFQGFHAFADQR||||| |||| |||  ::||||||||||||||||||||||||||||||||||||||| || g032MRRNVPAVAVLRRPRFEAFLDLALAQARAVPAGKQGFAVRCRLTQRQIVFQGFHAFAGQR        10        20        30        40        50        60        70        80        90       100       110       120 m032.pepHLPLXAPFADNVYPRXVQIDIICIQAVYLAHAQTAAVHQFEQGVVAHRQRVAAVHGQIQH:| | |||| ||||| ||| |||||||||||||||||||:|| ||||||||||||||||| g032NLTLLAPFAGNVYPRFVQIYIICIQAVYLAHAQTAAVHQLEQRVVAHRQRVAAVHGQIQH        70        80        90       100       110       120       130       140       150       160       170 m032.pepPVQPFLRQGFGYALGLLRRFDVGGRVGVHQAALYQPNAILPPRRKLASQRPFPQTA|||||||||||||||||||||||||||:|| |: ||:|||||||:|| |||  ||| g032PVQPFLRQGFGYALGLLRRFDVGGRVGAHQPAFDQPGAILPPRRQLARQRPTVQTALRQP       130       140       150       160       170       180 g032PQRRRKIAPRQVLRHAACIFRRHLCQQCKQFFQIAPVCRNRVLRLALAHDVFQISVKIRR       190       200       210       220       230       240The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 115>:

g033.seq 1 ATGGCGGCGG CGGACAAACT CTTGGGCGGC GACCGCCGCA GCGTCGCCAT 51CATCGGAGAC GGCGCGATGA CGGCGGGGCA GGCGTTTGAA GCCTTGAATT 101 GCGCGGGCGATATGGATGTG GATTTGCTGG TCGTCCTCAA CGACAACGAA 151 ATGTCGATTT CCCCCAACGTCGGCGCGTTG CCCAAATATC TTGCCAGCAA 201 CGTCGTGCGC GATATGCACG GACTGTTGAGTACCGTCAAA GCGCAAAcgg 251 GCAAGGTATT AGACAAAATA CCCGGCGCGA TGGagtTTGCCCAAAAAGTC 301 GAACAcaaaA TCAAAACCCT TGCCGAAGAA GCCGAACACG CCAAACAGTC351 GCTGTCGCTG TTTGAAAATT TCGGCTTCCG CTACACCGGC CCCGTGGACG 401GACACAACGT CGAGAATCTG GTGGACGTAT TGAAAGACTT GCGCAGCCGC 451 AAAGGCCCTCAGTTGCTGCA CGTCATCACC AAAAAGGGCA ACGGCTACAA 501 ACTCGCCGAA AACGACCCcgtcaAATACCA CGCCGTCGCc aACCTGCcta 551 AAGAAGGCGG GGCGCAAATg ccGTCTGAAAAAGAACCCAA GCCCGCCgCc 601 aaaccgACCT ATACCCAAGT ATTCGGCAAA TGGCTGTGCGACCGGGCGGC 651 GGCAGATTCC CGACTGGTTG CGATTACCCC CGCCATGCGC GAGGGCAGCG701 GACTGGTGGA GTTTGAACAA CGATTCCCCG ACCGCTATTT CGATGTCGGC 751ATCGCCGAGC AGCACGCCGT tacCTTTGCC GGCGGTTTGG CGTGCGAAGG 801 CATGAAGCCCGTCGTGGCGA TTTATTCCAC CTTTTTACAA CGCGCCTACG 851 ACCAACTGGT GCACGACATCGCCCTGCAAA ACCTGCCCGT TTTGTTTGCC 901 GTCGACCGTG CGGGCATCGT CGGCGCGGACGGTCCGACCC ATGCCGGCTT 951 GTACGATTTG AGCTTCTTGC GCTGTGTGCC GAACATGATTGTTGCCGCGC 1001 CGAGCGATGA AAACGAATGC CGCCTGCTGC TTTCGACCTG CTATCAGGCG1051 GATGCGCCCG CCGCCGTCCG CTATCCGCGC GGCACGGGTA CGGGCGCGCC 1101GGTTTCAGAC GGCATGGAAA CCGTGGAAAT CGGCAAGGGC ATTATCCGCC 1151 GCGAAGGTGAGAAAACCGCC TTcatTGCCT TCGGCAGTAT GGTCGCCACC 1201 GCATTGGCGG TTGCCGAAAAACTGAACGCC ACCGTCGCCG ATATGCGCTt 1251 cgtcaaacCG ATAGACGAAG AGTTGATTGTCCGCCTTGCC CGAAGCCAcg 1301 accGCATCGT TACCCTTGAA GAAAACGCCG AACAGGGCGGCGCAGGCGGC 1351 GCGGTCTTGG AAGTGTTGGC GAAACACGGC ATCTGCAAAC CCGTTTTGCT1401 TTTGGGCGTT GCCGATACCG TAACCGAACA CGGCGATCCG AAAAAACTTT 1451TGGACGATTT GGGTTTGAGT GCCGAAGCGG TGGAACGCCG GGTGCGCGAG 1501 TGGCTGCCGGACCGTGATGC GGCAAATTAAThis corresponds to the amino acid sequence <SEQ ID 116; ORF 033.ng>:

g033.pep 1 MAAADKLLGG DRRSVAIIGD GAMTAGQAFE ALNCAGDMDV DLLVVLNDNE 51MSISPNVGAL PKYLASNVVR DMHGLLSTVK AQTGKVLDKI PGAMEFAQKV 101 EHKIKTLAEEAEHAKQSLSL FENFGFRYTG PVDGHNVENL VDVLKDLRSR 151 KGPQLLHVIT KKGNGYKLAENDPVKYHAVA NLPKEGGAQM PSEKEPKPAA 201 KPTYTQVFGK WLCDRAAADS RLVAITPAMREGSGLVEFEQ RFPDRYFDVG 251 IAEQHAVTFA GGLACEGMKP VVAIYSTFLQ RAYDQLVHDIALQNLPVLFA 301 VDRAGIVGAD GPTHAGLYDL SFLRCVPNMI VAAPSDENEC RLLLSTCYQA351 DAPAAVRYPR GTGTGAPVSD GMETVEIGKG IIRREGEKTA FIAFGSMVAT 401ALAVAEKLNA TVADMRFVKP IDEELIVRLA RSHDRIVTLE ENAEQGGAGG 451 AVLEVLAKHGICKPVLLLGV ADTVTEHGDP KKLLDDLGLS AEAVERRVRE 501 WLPDRDAAN*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 117>:

m033.seq 1 ATGGCGGCGG CAGACAAACT CTTGGGCAGC GACCGCCGCA GCGTCGCCAT 51CATCGGCGAC GGCGCGATGA CGGCGGGGCA GGCGTTTGAA GCCTTGAATT 101 GCGCaG.CGATATGGATGTr GATTTGCTrG TCGTCCTCAA CGACAACGAA 151 ATGTCGATTT CCCCCAACGTCGGCGCGCTG CCGAAATACC TTGCCAGCAA 201 CGTCGTGCGC GATATGCACG GCCTGTTGAGTACCGTCAAA GCGCAAACGG 251 GCAAGGTATT AGACAAAATA CCCGGCGCGA TGGAGTTTGCCCAAAAAGTC 301 GAACACAAAA TCAAAACCCT TGCCGAAGAA GCCGAACACG CCAAACAGTC351 GCTGTCTTTG TTTGAAAACT TCGGCTTCCG CTACACCGGC CCCGTGGACG 401GACACAACGT CGAAAATCTG GTGGACGTAT TGAAAGACTT GCGCAGCCGC 451 AAAGGCCCTCAGTTGCTGCA CGTCATCACC AAAAAGGGCA ACGGCTACAA 501 ACTCGCCGAA AACGACCCCGTCAAATACCA CGCCGTCGCC AACCTGCCTA 551 AAGAAAGCGC GGCGCAAATG CCGTCTGAAAAAGAACCCAA GCCCGCCGCC 601 AAACCGACCT ATACCCAAGT GTTCGGCAAA TGGCTGTGCGACCGGGCGGC 651 GGCAGATTCC CGACTGGTTG CGATTACCCC CGCCATGCGC GAGGGCAGCG701 GCTTGGTTGA GTTTGAACAA CGATTCCCCG ACCGCTATTT CGATGTCGGC 751ATCGCCGAGC AGCACGCCGT TACCTTTGCC GGCGGTTTGG CTTGCGAAGG 801 GATGAAGCCCGTCGTGGCGA TTTATTCCAC CTTTTTACAA CGCGCCTACG 851 ACCAACTGGT GCACGACATCGCCCTGCAAA ACCTACCCGT TTTGTTTGCC 901 GTCGACCGCG CGGGCATCGT CGGCGCGGACGGCCCGACCC ATGCCGGTCT 951 GTACGATTTG AGCTTTTTGC GCTGCGTGCC GAACATGATTGTCGCCGCGC 1001 CGAGCGATGA AAACGAATGC CGCCTGTTGC TTTCGACCTG CTATCAGGCA1051 GACGCGCCCG CCGCCGTCCG CTATCCGCGC GGCACGGGTA CGGGCGCGCC 1101GGTTTCAGAC GGCATGGAAA CCGTGGAAAT CGGCAAGGGC ATTATCCGCC 1151 GCGAAGGTGAGAAAACCGCA TTCATTGCCT TCGGCAGTAT GGTCGCCCCC 1201 GCATTGGCGG TTGCCGAAAAACTGAACGCC ACCGTCGCCG ATATGCGCTT 1251 CGTCAAACCG ATAGACGAAG AGTTGATTGTCCGCCTTGCC CGAAGCCACG 1301 ACCGCATCGT TACCCTTGAA GAAAACGCCG AACAGGGCGGCGCAGGCGGC 1351 GCGGTGCTGG AAGTATTGGC GAAACACGGC ATCTGCAAAC CCGTTTTGCT1401 TTTGGGCGTT GCCGATACCG TAACCGGACA CGGCGATCCG AAAAAACTTT 1451TAGACGATTT GGGCTTGAGT GCCGAAGCGG TGGAACGGCG TGTGCGCGCG 1501 TGGCTGTCGGATCGGGATGC GGCAAATTAAThis corresponds to the amino acid sequence <SEQ ID 118; ORF 033>:

m033.pep 1 MAAADKLLGS DRRSVAIIGD GAMTAGQAFE ALNCAXDMDV DLLVVLNDNE 51MSISPNVGAL PKYLASNVVR DMHGLLSTVK AQTGKVLDKI PGAMEFAQKV 101 EHKIKTLAEEAEHAKQSLSL FENFGFRYTG PVDGHNVENL VDVLKDLRSR 151 KGPQLLHVIT KKGNGYKLAENDPVKYHAVA NLPKESAAQM PSEKEPKPAA 201 KPTYTQVFGK WLCDRAAADS RLVAITPAMREGSGLVEFEQ RFPDRYFDVG 251 IAEQHAVTFA GGLACEGMKP VVAIYSTFLQ RAYDQLVHDIALQNLPVLFA 301 VDRAGIVGAD GPTHAGLYDL SFLRCVPNMI VAAPSDENEC RLLLSTCYQA351 DAPAAVRYPR GTGTGAPVSD GMETVEIGKG IIRREGEKTA FIAFGSMVAP 401ALAVAEKLNA TVADMRFVKP IDEELIVRLA RSHDRIVTLE ENAEQGGAGG 451 AVLEVLAKHGICKPVLLLGV ADTVTGHGDP KKLLDDLGLS AEAVERRVRA 501 WLSDRDAAN*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 119>:

a033.seq 1 ATGGCGGCGG CGGACAAACA GTTGGGCAGC GACCGCCGCA GCGTCGCCAT 51CATCGGCGAC GGCGCGATGA CGGCGGGTCA GGCGTTTGAA GCCTTGAACT 101 GCGCGGGCGATATGGATGTG GATTTGCTGG TCGTCCTCAA CGACAACGAA 151 ATGTCGATTT CCCCCAACGTCGGTGCGTTG CCCAAATACC TTGCCAGCAA 201 CGTCGTGCGC GATATGCACG GACTGTTGAGTACCGTCAAA GCGCAAACGG 251 GCAAGGTATT AGACAAAATA CCCGGCGCGA TGGAGTTTGCCCAAAAAGTC 301 GAACATAAAA TCAAAACCCT TGCCGAAGAA GCCGAACACG CCAAACAGTC351 ACTGTCTTTG TTTGAAAACT TCGGCTTCCG CTATACCGGC CCCGTGGACG 401GACACAACGT CGAAAATCTG GTCGATGTAT TGGAAGACCT GCGCGGACGC 451 AAAGGCCCGCAGCTTCTGCA CGTCATCACC AAAAAGGGCA ACGGCTACAA 501 ACTCGCCGAA AACGATCCCGTCAAATACCA CGCCGTCGCC AACCTGCCTA 551 AAGAAAGCGC GGCGCAAATG CCGTCTGAAAAAGAACCCAA GCCCGCCGCC 601 AAACCGACCT ATACCCAAGT GTTCGGCAAA TGGCTGTGCGACCGGGCGGC 651 GGCAGATTCC CGACTGGTTG CGATTACCCC CGCCATGCGC GAGGGCAGCG701 GCTTGGTTGA GTTTGAACAA CGATTCCCCG ACCGCTATTT CGATGTCGGC 751ATCGCCGAGC AGCACGCCGT TACCTTTGCC GGCGGTTTGG CTTGCGAAGG 801 GATGAAGCCCGTCGTGGCGA TTTATTCCAC CTTTTTACAA CGCGCCTACG 851 ACCAACTGGT GCACGACATCGCCCTGCAAA ACCTGCCCGT TTTGTTTGCC 901 GTCGACCGCG CGGGCATCGT CGGCGCGGACGGCCCGACCC ATGCCGGTTT 951 GTACGATTTA AGCTTTTTGC GCTGCATTCC GAATATGATTGTCGCCGCGC 1001 CGAGCGATGA AAATGAATGC CGCCTGCTGC TTTCGACCTG CTATCAGGCA1051 GACGCGCCCG CCGCCGTCCG CTATCCGCGC GGCACGGGTA CGGGCGTGCC 1101GGTTTCAGAC GGCATGGAAA CCGTGGAAAT CGGCAAGGGC ATTATCCGCC 1151 GCGAAGGTGAGAAAACCGCA TTCATTGCCT TCGGCAGTAT GGTCGCCCCT 1201 GCATTGGCGG TCGCCGGAAAACTGAACGCC ACCGTCGCCG ATATGCGCTT 1251 CGTCAAACCG ATAGACGAAG AGTTGATTGTCCGCCTTGCC CGAAGCCACG 1301 ACCGCATCGT TACCCTTGAA GAAAACGCCG AACAGGGCGGCGCAGGCAGC 1351 GCGGTGCTGG AAGTGTTGGC GAAACACGGC ATCTGCAAAC CCGTCTTGCT1401 TTTGGGCGTT GCCGATACCG TAACCGGACA CGGCGATCCG AAAAAACTTT 1451TAGACGATTT GGGCTTGAGT GCCGAAGCGG TGGAACGGCG TGTGCGCGCG 1501 TGGCTGTCGGATCGGGATGC GGCAAATTAAThis corresponds to the amino acid sequence <SEQ ID 120; ORF 033.a>:

a033.pep 1 MAAADKQLGS DRRSVAIIGD GAMTAGQAFE ALNCAGDMDV DLLVVLNDNE 51MSISPNVGAL PKYLASNVVR DMHGLLSTVK AQTGKVLDKI PGAMEFAQKV 101 EHKIKTLAEEAEHAKQSLSL FENFGFRYTG PVDGHNVENL VDVLEDLRGR 151 KGPQLLHVIT KKGNGYKLAENDPVKYHAVA NLPKESAAQM PSEKEPKPAA 201 KPTYTQVFGK WLCDRAAADS RLVAITPAMREGSGLVEFEQ RFPDRYFDVG 251 IAEQHAVTFA GGLACEGMKP VVAIYSTFLQ RAYDQLVHDIALQNLPVLFA 301 VDRAGIVGAD GPTHAGLYDL SFLRCIPNMI VAAPSDENEC RLLLSTCYQA351 DAPAAVRYPR GTGTGVPVSD GMETVEIGKG IIRREGEKTA FIAFGSMVAP 401ALAVAGKLNA TVADMRFVKP IDEELIVRLA RSHDRIVTLE ENAEQGGAGS 451 AVLEVLAKHGICKPVLLLGV ADTVTGHGDP KKLLDDLGLS AEAVERRVRA 501 WLSDRDAAN* m033/a03398.4% identity over a 509 aa overlap        10        20        30        40        50        60 m033.pepMAAADKLLGSDRRSVAIIGDGAMTAGQAFEALNCAXDMDVDLLVVLNDNEMSISPNVGAL|||||| |||||||||||||||||||||||||||| |||||||||||||||||||||||| a033MAAADKQLGSDRRSVAIIGDGAMTAGQAFEALNCAGDMDVDLLVVLNDNEMSISPNVGAL        10        20        30        40        50        60        70        80        90       100       110       120 m033.pepPKYLASNVVRDMHGLLSTVKAQTGKVLDKIPGAMEFAQKVEHKIKTLAEEAEHAKQSLSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a033PKYLASNVVRDMHGLLSTVKAQTGKVLDKIPGAMEFAQKVEHKIKTLAEEAEHAKQSLSL        70        80        90       100       110       120       130       140       150       160       170       180 m033.pepFENFGFRYTGPVDGHNVENLVDVLKDLRSRKGPQLLHVITKKGNGYKLAENDPVKYHAVA||||||||||||||||||||||||:|||:||||||||||||||||||||||||||||||| a033FENFGFRYTGPVDGHNVENLVDVLEDLRGRKGPQLLHVITKKGNGYKLAENDPVKYHAVA       130       140       150       160       170       180       190       200       210       220       230       240 m033.pepNLPKESAAQMPSEKEPKPAAKPTYTQVFGKWLCDRAAADSRLVAITPAMREGSGLVEFEQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a033NLPKESAAQMPSEKEPKPAAKPTYTQVFGKWLCDRAAADSRLVAITPAMREGSGLVEFEQ       190       200       210       220       230       240       250       260       270       280       290       300 m033.pepRFPDRYFDVGIAEQHAVTFAGGLACEGMKPVVAIYSTFLQRAYDQLVHDIALQNLPVLFA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a033RFPDRYFDVGIAEQHAVTFAGGLACEGMKPVVAIYSTFLQRAYDQLVHDIALQNLPVLFA       250       260       270       280       290       300       310       320       330       340       350       360 m033.pepVDRAGIVGADGPTHAGLYDLSFLRCVPNMIVAAPSDENECRLLLSTCYQADAPAAVRYPR|||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||| a033VDRAGIVGADGPTHAGLYDLSFLRCIPNMIVAAPSDENECRLLLSTCYQADAPAAVRYPR       310       320       330       340       350       360       370       380       390       400       410       420 m033.pepGTGTGAPVSDGMETVEIGKGIIRREGEKTAFIAFGSMVAPALAVAEKLNATVADMRFVKP|||||:||||||||||||||||||||||||||||||||||||||| |||||||||||||| a033GTGTGVPVSDGMETVEIGKGIIRREGEKTAFIAFGSMVAPALAVAGKLNATVADMRFVKP       370       380       390       400       410       420       430       440       450       460       470       480 m033.pepIDEELIVRLARSHDRIVTLEENAEQGGAGGAVLEVLAKHGICKPVLLLGVADTVTGHGDP|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| a033IDEELIVRLARSHDRIVTLEENAEQGGAGSAVLEVLAKHGICKPVLLLGVADTVTGHGDP       430       440       450       460       470       480       490       500       510 m033.pep KKLLDDLGLSAEAVERRVRAWLSDRDAANX|||||||||||||||||||||||||||||| a033 KKLLDDLGLSAEAVERRVRAWLSDRDAANX       490       500       510Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 033 shows 98.4% identity over a 509 aa overlap with a predicted ORF(ORF 033.ng) from N. gonorrhoeae:

m033/g033 m033.pepMAAADKLLGSDRRSVAIIGDGAMTAGQAFEALNCAXDMDVDLLVVLNDNEMSISPNVGAL 60|||||||||:||||||||||||||||||||||||| |||||||||||||||||||||||| g033MAAADKLLGGDRRSVAIIGDGAMTAGQAFEALNCAGDMDVDLLVVLNDNEMSISPNVGAL 60 m033.pepPKYLASNVVRDMHGLLSTVKAQTGKVLDKIPGAMEFAQKVEHKIKTLAEEAEHAKQSLSL 120|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g033PKYLASNVVRDMHGLLSTVKAQTGKVLDKIPGAMEFAQKVEHKIKTLAEEAEHAKQSLSL 120m033.pep FENFGFRYTGPVDGHNVENLVDVLKDLRSRKGPQLLHVITKKGNGYKLAENDPVKYHAVA180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g033FENFGFRYTGPVDGHNVENLVDVLKDLRSRKGPQLLHVITKKGNGYKLAENDPVKYHAVA 180m033.pep NLPKESAAQMPSEKEPKPAAKPTYTQVFGKWLCDRAAADSRLVAITPAMREGSGLVEFEQ240 |||||::||||||||||||||||||||||||||||||||||||||||||||||||||||| g033NLPKEGGAQMPSEKEPKPAAKPTYTQVFGKWLCDRAAADSRLVAITPAMREGSGLVEFEQ 240m033.pep RFPDRYFDVGIAEQHAVTFAGGLACEGMKPVVAIYSTFLQRAYDQLVHDIALQNLPVLFA300 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g033RFPDRYFDVGIAEQHAVTFAGGLACEGMKPVVAIYSTFLQRAYDQLVHDIALQNLPVLFA 300m033.pep VDRAGIVGADGPTHAGLYDLSFLRCVPNMIVAAPSDENECRLLLSTCYQADAPAAVRYPR360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g033VDRAGIVGADGPTHAGLYDLSFLRCVPNMIVAAPSDENECRLLLSTCYQADAPAAVRYPR 360m033.pep GTGTGAPVSDGMETVEIGKGIIRREGEKTAFIAFGSMVAPALAVAEKLNATVADMRFVKP420 ||||||||||||||||||||||||||||||||||||||| |||||||||||||||||||| g033GTGTGAPVSDGMETVEIGKGIIRREGEKTAFIAFGSMVATALAVAEKLNATVADMRFVKP 420m033.pep IDEELIVRLARSHDRIVTLEENAEQGGAGGAVLEVLAKHGICKPVLLLGVADTVTGHGDP480 ||||||||||||||||||||||||||||||||||||||||||||||||||||||| |||| g033IDEELIVRLARSHDRIVTLEENAEQGGAGGAVLEVLAKHGICKPVLLLGVADTVTEHGDP 480m033.pep KKLLDDLGLSAEAVERRVRAWLSDRDAANX 510||||||||||||||||||| || ||||||| g033 KKLLDDLGLSAEAVERRVREWLPDRDAANX 510The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 121>:

g034.seq 1 ATGAGCCGTT TATGGTTTTT TGCCGTAAAA AACATTATAA TCCGCCTTAT 51TTACCTATTG CCCAAGGAGA CACAAATGGC ACTCGTATCC ATGCGCCAAC 101 TGCTTGACCACGCCGCCGAA AACAGCTACG GCCTGCCCGC GTTCAACGTC 151 AACAACCTCG AACAAATGCGCGCCATTATG GAAGCCGCCG ACCAAGTCAA 201 CGCGCCCGTC ATCGTACAGG CGAGCGCAGGTGCGCGCAAA TACGcggGCG 251 CGCCGTTTTT GCGCCACCTG ATTCTGGCGG CAGTCGAAGAATTTCCGCAC 301 ATCCCCGTCG TGATGCACCA AGACCACGGC GCATCGCCCG ACGTgtgCCA351 ACGCTCCATC CAACTGGGCT TCTCCTCCGT GATGATGGAC GGCTCTTTGC 401TCGAAGACGG CAAAACCCCT TCTTCTTACG AATACAACGT CAACGCCACC 451 CGTACCGTCGTCAACTTCTC CCACGCCTGC GGCGTGTCCG TCGAAGGCGA 501 AATCGGCGTA TTGGGCAACCTCGAAACCGG CGAAGCAGGC GAAGAAGACG 551 GAGTGGGCGC GGCAGGCAAA CTCTCACACGACCAAATGCT CACCAGCGTT 601 GAAGATGCCG TGCGTTTCGT TAAAGATACC GGCGTTGACGCATTGGCGAT 651 TGCCGTCGGC ACCAGCCACG GCGCATACAA ATTCACCCGT CCGCCCACAG701 GCGACGTATT GCGTATCGAC CGCATCAAGG AAATCCACCA AGCCCTGCCC 751AATACACACA TCGTGATGCA CGgctCCAGC TCCGTTCCGC AAGAatgGCT 801 GAAAGTCATCAACGAATACG GCGGCAATAT CGGCGAAACC TACGGCGTGC 851 CGGTTGAAGA AATCGTCGAAGGCATCAAAC ACGGCGTGCG CAAAGTCAAC 901 ATCGATACCG ACCTGCGCCT CGCTTCCACCGGCGCGGTAC GCCGCTACCT 951 TGCCGAAAAC CCGTCCGACT TTGATCCGCG CAAATACTTGGGCAAAACCA 1001 TTGAAGCGAT GAAGCAAATC TGCCTCGACC GTTATCTTGC GTTCGGTTGC1051 GAAGGTCAGG CAGGCAAAAT CAAACCTGTT TCGTTGGAAA AAATGGCAAG 1101CCGTTATGCC AAGGGCGAAT TGAACCAAAT CGTCAAATAAThis corresponds to the amino acid sequence <SEQ ID 122; ORF 034.ng>:

g034.pep 1 MSRLWFFAVK NIIIRLIYLL PKETQMALVS MRQLLDHAAE NSYGLPAFNV 51NNLEQMRAIM EAADQVNAPV IVQASAGARK YAGAPFLRHL ILAAVEEFPH 101 IPVVMHQDHGASPDVCQRSI QLGFSSVMMD GSLLEDGKTP SSYEYNVNAT 151 RTVVNFSHAC GVSVEGEIGVLGNLETGEAG EEDGVGAAGK LSHDQMLTSV 201 EDAVRFVKDT GVDALAIAVG TSHGAYKFTRPPTGDVLRID RIKEIHQALP 251 NTHIVMHGSS SVPQEWLKVI NEYGGNIGET YGVPVEEIVEGIKHGVRKVN 301 IDTDLRLAST GAVRRYLAEN PSDFDPRKYL GKTIEAMKQI CLDRYLAFGC351 EGQAGKIKPV SLEKMASRYA KGELNQIVK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 123>:

m034.seq (partial) 1 ATGAGCTGTT TATGGTTTTT TGCTGTAAAA AACATTATAATCCGCCTTAT 51 TTACCTATTG CCCAAGGAGA CACAAATGGC ACTCGTATCC ATGCGCCAAC 101TGCTTGATCA TGCTGCCGAA wACAGCTACG GCyTGCCGGC GTTCAACGTC 151 AACAACCTCGwACAGATGCG CGCCATCATG GAGGCTGCAG ACCAAGTCGA 201 CGCCCCCGTC ATCGTACAGGCGAGTGCCGG TGCGCGCAAA TATGCGGGTG 251 CGCCGTTTTT ACGCCACCTG ATTTTGGCGGCTGTCGAAGT ATTTCCACAC 301 ATCCCCGTCG TCATGCACCA AGACCACGGC GCATCACCCGACGTGTGCCA 351 ACGCTCCATC CAACTGGGCT TCTCCTCTGT AATGATGGAC GGCTCGCTGA401 TGGAAGACGG CAAAACCCCT TCTTCTTACG AATACAACGT CAACGCCACA 451CGTACCGTGG TTAACTTCTC CCACGCTTGC GGCGTATCCG TTGAAGGCGA 501 AATCGGCGTATTGGGCAACC TCGAAACCGG CGATGCAGGC GAAGAAGACG 551 GTGTAGGCGC AGTGGGCAAACTTTCCCACG ACCAAATGCT GACCAGCGTC 601 GAAGATGCCG TATGTTTCGT TAAAGATACCGGCGTTGACG CATTGGCTAT 651 TGCCGTCGGC ACCAGCCACG GCGCATACAA ATTCACCCGTCCGCCCACAG 701 GCGATGTATT ACGTATCGAC CGCATCAAAG AAATCCACCA AGCCCTGCCC751 AATACACACA TCGTGATGCA C...This corresponds to the amino acid sequence <SEQ ID 124; ORF 034>:

m034.pep (partial) 1 MSCLWFFAVK NIIIRLIYLL PKETQMALVS MRQLLDHAAEXSYGLPAFNV 51 NNLXQMRAIM EAADQVDAPV IVQASAGARK YAGAPFLRHL ILAAVEVFPH 101IPVVMHQDHG ASPDVCQRSI QLGFSSVMMD GSLMEDGKTP SSYEYNVNAT 151 RTVVNFSHACGVSVEGEIGV LGNLETGDAG EEDGVGAVGK LSHDQMLTSV 201 EDAVCFVKDT GVDALAIAVGTSHGAYKFTR PPTGDVLRID RIKEIHQALP 251 NTHIVMH...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 125>:

a034.seq 1 ATGAGCCGTT TATGGTTTTT TGCCGCAAAA AACATTATAA TCCGCCTTAT 51TTACCTATTG CCCAAGGAGA CACAAATGGC ACTCGTATCC ATGCGCCAAC 101 TGCTTGATCATGCTGCCGAA AACAGCTACG GCCTGCCCGC GTTCAACGTC 151 AACAACCTCG AACAAATGCGCGCCATTATG GAAGCCGCCG ACCAAGTCAA 201 CGCGCCCGTC ATCGTACAGG CGAGCGCAGGTGCGCGCAAA TACGCGGGCG 251 CGCCGTTTTT GCGCCACCTG ATTTTGGCGG CTGTCGAAGAATTTCCGCAC 301 ATCCCCGTCG TGATGCACCA AGACCACGGC GCATCGCCCG ACGTGTGCCA351 ACGCTCCATC CAACTGGGCT TTTCCTCCGT GATGATGGAC GGCTCGCTGA 401TGGAAGACGG CAAAACCCCT TCTTCTTATG AATACAACGT CAACGCCACC 451 CGTACCGTGGTTAATTTCTC CCACGCCTGC GGCGTATCCG TTGAAGGCGA 501 AATCGGCGTA TTGGGCAACCTCGAAACTGG CGAAGCCGGC GAAGAAGACG 551 GTGTAGGCGC AGTGGGCAAA CTTTCCCACGACCAAATGCT CACCAGCGTC 601 GAAGATGCCG TGCGTTTCGT TAAAGATACC GGCGTTGACGCATTGGCGAT 651 TGCCGTCGGC ACCAGCCACG GCGCGTACAA ATTCACCCGT CCGCCCACAG701 GCGACGTGTT GCGTATCGAC CGCATCAAAG AAATCCACCA AGCCCTGCCC 751AATACACACA TCGTGATGCA CGGCTCCAGC TCCGTTCCGC AAGAATGGCT 801 GAAAGTCATCAACGAATACG GCGGCAATAT CGGCGAAACC TACGGCGTGC 851 CGGTTGAAGA AATCGTCGAAGGCATCAAAC ACGGCGTGCG TAAAGTCAAC 901 ATCGATACCG ACTTGCGCCT TGCTTCCACCGGCGCGGTAC GCCGCTACCT 951 TGCCGAAAAC CCGTCCGACT TCGATCCGCG CAAATATTTGAGCAAAACCA 1001 TTGAAGCGAT GAAGCAAATC TGCCTCGACC GCTACCTCGC GTTCGGTTGC1051 GAAGGTCAGG CAGGCAAAAT CAAACCGGTT TCCTTGGAAA AAATGGCAAA 1101CCGTTATGCC AAGGGCGAAT TGAACCAAAT CGTCAAATAAThis corresponds to the amino acid sequence <SEQ ID 126; ORF 034.a>:

a034.pep 1 MSRLWFFAAK NIIIRLIYLL PKETQMALVS MRQLLDHAAE NSYGLPAFNV 51NNLEQMRAIM EAADQVNAPV IVQASAGARK YAGAPFLRHL ILAAVEEFPH 101 IPVVMHQDHGASPDVCQRSI QLGFSSVMMD GSLMEDGKTP SSYEYNVNAT 151 RTVVNFSHAC GVSVEGEIGVLGNLETGEAG EEDGVGAVGK LSHDQMLTSV 201 EDAVRFVKDT GVDALAIAVG TSHGAYKFTRPPTGDVLRID RIKEIHQALP 251 NTHIVMHGSS SVPQEWLKVI NEYGGNIGET YGVPVEEIVEGIKHGVRKVN 301 IDTDLRLAST GAVRRYLAEN PSDFDPRKYL SKTIEAMKQI CLDRYLAFGC351 EGQAGKIKPV SLEKMANRYA KGELNQIVK* m034/a034 96.9% identity over a 257aa overlap         10        20        30        40        50        60m034.pep MSCLWFFAVKNIIIRLIYLLPKETQMALVSMRQLLDHAAEXSYGLPAFNVNNLXQMRAIM|| |||||:||||||||||||||||||||||||||||||| |||||||||||| |||||| a034MSRLWFFAAKNIIIRLIYLLPKETQMALVSMRQLLDHAAENSYGLPAFNVNNLEQMRAIM        10        20        30        40        50        60        70        80        90       100       110       120 m034.pepEAADQVDAPVIVQASAGARKYAGAPFLRHLILAAVEVFPHIPVVMHQDHGASPDVCQRSI||||||:||||||||||||||||||||||||||||| ||||||||||||||||||||||| a034EAADQVNAPVIVQASAGARKYAGAPFLRHLILAAVEEFPHIPVVMHQDHGASPDVCQRSI        70        80        90       100       110       120       130       140       150       160       170       180 m034.pepQLGFSSVMMDGSLMEDGKTPSSYEYNVNATRTVVNFSHACGVSVEGEIGVLGNLETGDAG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| a034QLGFSSVMMDGSLMEDGKTPSSYEYNVNATRTVVNFSHACGVSVEGEIGVLGNLETGEAG       130       140       150       160       170       180       190       200       210       220       230       240 m034.pepEEDGVGAVGKLSHDQMLTSVEDAVCFVKDTGVDALAIAVGTSHGAYKFTRPPTGDVLRID|||||||||||||||||||||||| ||||||||||||||||||||||||||||||||||| a034EEDGVGAVGKLSHDQMLTSVEDAVRFVKDTGVDALAIAVGTSHGAYKFTRPPTGDVLRID       190       200       210       220       230       240        250m034.pep RIKEIHQALPNTHIVMH ||||||||||||||||| a034RIKEIHQALPNTHIVMHGSSSVPQEWLKVINEYGGNIGETYGVPVEEIVEGIKHGVRKVN       250       260       270       280       290       300Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 034 shows 96.5% identity over a 257 aa overlap with a predicted ORF(ORF 034.ng) from N. gonorrhoeae:

m034/g034 m034.pepMSCLWFFAVKNIIIRLIYLLPKETQMALVSMRQLLDHAAEXSYGLPAFNVNNLXQMRAIM 60|| ||||||||||||||||||||||||||||||||||||| |||||||||||| |||||| g034MSRLWFFAVKNIIIRLIYLLPKETQMALVSMRQLLDHAAENSYGLPAFNVNNLEQMRAIM 60 m034.pepEAADQVDAPVIVQASAGARKYAGAPFLRHLILAAVEVFPHIPVVMHQDHGASPDVCQRSI 120||||||:||||||||||||||||||||||||||||| ||||||||||||||||||||||| g034EAADQVNAPVIVQASAGARKYAGAPFLRHLILAAVEEFPHIPVVMHQDHGASPDVCQRSI 120m034.pep QLGFSSVMMDGSLMEDGKTPSSYEYNVNATRTVVNFSHACGVSVEGEIGVLGNLETGDAG180 |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||:|| g034QLGFSSVMMDGSLLEDGKTPSSYEYNVNATRTVVNFSHACGVSVEGEIGVLGNLETGEAG 180m034.pep EEDGVGAVGKLSHDQMLTSVEDAVCFVKDTGVDALAIAVGTSHGAYKFTRPPTGDVLRID240 |||||||:|||||||||||||||| ||||||||||||||||||||||||||||||||||| g034EEDGVGAAGKLSHDQMLTSVEDAVRFVKDTGVDALAIAVGTSHGAYKFTRPPTGDVLRID 240m034.pep RIKEIHQALPNTHIVMH 257 ||||||||||||||||| g034RIKEIHQALPNTHIVMHGSSSVPQEWLKVINEYGGNIGETYGVPVEEIVEGIKHGVRKVN 300The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 127>:

g036.seq 1 ATGCTGAAGC CGTGTTTGGT ATACAGTGCC TGTGCGGCGG cgttgcCTGC 51GCGGACTTCG AGCAGCAGGC GTTGCGTGCC TTCGGGCAGA TGTGCGTACC 101 AATATTCGAGCAGGGCGGAC GCAACGCCCC GTCGGCGGCA TTCGGGCGCG 151 GTGGCAATCA GGTGCAGTTCGGATTCGTCG GGCAGGTTCT GCCAAACGAT 201 AAAGGCGGCA ATCCTGCCGT CTTTTTCCGCAAGGAAAACC TGTTCGGACG 251 GCGAAACAAG CGCGGACTCA AATTGGCGTT GCGTCCACGCGGACGGGTTG 301 CAGACGGTAT CGAGCGCGGC CAGTGCGGCG CAGTCGGACG GTGAGGCTGG351 GCGGATGTTC ATGTTCGTGC CTTCCGTTCC GCCTGTTCTT TGGCAGTCAG 401GGCGATTTTG TTGCGGACGT AGAGCAGTTC GGCGTGTGCC GCGCCAGTTG 451 CGGGATAGCCGCCGCCGAGG GCGAGCGCGA GAAAATCGGC GGCGGTCGGC 501 ATATCGGGTT TGCCTGAGAAGGGCGGACGG TTTTCCAGTG CGAACGCACT 551 GCCGATGCCG TCTGAAAAGA CGTACCCCTCGGGGAGGGCA ATGTCTGCCG 601 CCCTACCGAC TTGATAATCG CTCAAACGGC GGCGGTTCAGCGTGTCGAAC 651 CACGCATAAA ACACTTCGCC CATACGCGCG TCCGCAGCGG CGAGTATGCA701 GCTTTGCGGC GGCGGCAGCG AGGCGGCGGC ATCGAGCGTG GGGATGCCGA 751TTAAAGGCGT GTCGAACGGC GTTGCCAAAC CTTGCGCCAC GCCGATGCCG 801 ATACGCAGTCCGGTAAThis corresponds to the amino acid sequence <SEQ ID 128; ORF 036.ng>:

g036.pep 1 MLKPCLVYSA CAAALPARTS SSRRCVPSGR CAYQYSSRAD ATPRRRHSGA 51VAIRCSSDSS GRFCQTIKAA ILPSFSARKT CSDGETSADS NWRCVHADGL 101 QTVSSAASAAQSDGEAGRMF MFVPSVPPVL WQSGRFCCGR RAVRRVPRQL 151 RDSRRRGRAR ENRRRSAYRVCLRRADGFPV RTHCRCRLKR RTPRGGQCLP 201 PYRLDNRSNG GGSACRTTHK TLRPYARPQRRVCSFAAAAA RRRHRAWGCR 251 LKACRTALPN LAPRRCRYAV R*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 129>:

m036.seq 1 ATGCTGAAGC CGTGCGCCGT GTACAGTGCC TGTGCGGCGG TGTTGCCTGC 51ACGGACTTCG AGCAGCAGGC GTTGCGTGTC TTCGGGCAGA TGTGTGAACC 101 AATATTCGAGCAGGGCGGAC GCAATTCCTT GGCGGCGGCA TTCGGGCGCG 151 GTGGCAATCA GGTGCAGTTCGGATTCGTCG GGCAGGTTCT GCCAAACGAT 201 AAAGGCGGCA ATCCCg.CGT CTTTTTCCGCAAGGAAAACC TGTTCGGACG 251 GCGAAACCAG TGCGGACTCA AATTGGCGTT GCGTCCATGCGGACGGGTTG 301 CAGACGGCAT CGAGTGCGGC CAGCTCCTCA CAATCGGCAC AAACGGCACG351 GCGGATGTTC ACGGGCGCGC TCTCCGTTCG GCCTGTTCTT TGGCAGTCAG 401GGCGATTTTG TTGCGGACGT AGAGCAAACC GGCGTGTGCG GCATGGACGG 451 CAGGATAACCGCCCTTGGCT GCCAATGCGA GAAAGTCGGC GGCAGTCGGC 501 ATATCCGGTC TGCCTGAGAACGGCGGAGCT TCTTCCAGCG CGAACGCGCT 551 GCCTATGCCG TCTGAAAAGG CGCATCCCTCCGGCAGCCGG ATGTCTGCCG 601 CCCGCCCGAC CTGATAATCG CTCAAACGGT GGCAGTTCAGCGTATCGAAC 651 CATGCATAAA ACACTTCGCC CATACGAGCG TCCGTAGCGG CAAGGATGCA701 GCTTTGCGGC GGCGGCAGCG AGGCGGCGGC ATCGAGCGAG GGTACGCCGA 751TTAAGGGGGT ATCAAACGGC GTTGCCAAAC CCTGAGCTAC ACCGATGCCG 801 ATACGCAGTCCGGTAAThis corresponds to the amino acid sequence <SEQ ID 130; ORF 036>:

m036.pep 1 MLKPCAVYSA CAAVLPARTS SSRRCVSSGR CVNQYSSRAD AIPWRRHSGA 51VAIRCSSDSS GRFCQTIKAA IPXSFSARKT CSDGETSADS NWRCVHADGL 101 QTASSAASSSQSAQTARRMF TGALSVRPVL WQSGRFCCGR RANRRVRHGR 151 QDNRPWLPMR ESRRQSAYPVCLRTAELLPA RTRCLCRLKR RIPPAAGCLP 201 PARPDNRSNG GSSAYRTMHK TLRPYERP*RQGCSFAAAAA RRRHRARVRR 251 LRGYQTALPN PELHRCRYAV R*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 131>:

a036.seq 1 ATGCTGAAGC CGTGCGCCGT GTACAGTGCC TGTGCGGCGG TGTTGCCTGC 51ACGGACTTCG AGCAGCAGGC GTTGCGTGTC TTCGGGCAGA TGTGTGAACC 101 AATATTCGAGCAGGGCGGAC GCAATTCCTT GGCGGCGGCA TTCGGGCGCG 151 GTGGCAATCA GGTGCAGTTCGGATTCGTCG GGCAGGTTCT GCCAAACGAT 201 AAAGGCGGCA ATCCCGCCGT CTTTTTCCGCAAGGAAAACC TGTTCGGACG 251 GCGAAACCAG TGCGGACTCA AATTGGCGTT GCGTCCACGCGGACGGGTTG 301 CAGACGGCAT CGAGCGCGGC GAGTGCGGCG CAATCGGCAT AAACGGCGCG351 GCGGATGTTC ACAGGCGCGC CCTCCGTTCC GCCTGTTCTT TGGCAGTCAA 401GGCGATTTTG TTGCGGACGT AGAGCAGCTC GGCGTGTGCC GCAGCGACGG 451 CGGGAAAACCGCCTTCAGCC GCCAGATTGA GGAAGTCGGC GGCGGTCGGC 501 ATATCGGGTT TGCCTGAGAAGGGCGGACGG TTTTCCAGCG CGAACGCATT 551 GCCGATGCCG TCTGAAAAGG CGCATCCTTCCGGCAGCCGG ATGTCTGCCG 601 CCCGACCGAC CTGATAATCG CTCAAACGGC GGCGGTTCAGCGTGTCGAAC 651 CATGCATAAA ACACTTCGCC CATACGTGCG TCCGCAGCGG CAAGGATGCA701 GCTTTGCGGC GGCGGCAGCG AGGCGGCGGC ATCGAGCGAG GGTACGCCGA 751TTAAAGGAGT ATCAAACGGC GTTGCCAAAC CTTGCGCCAC GCCGATGCCG 801 ATACGCAGTCCCGTAAThis corresponds to the amino acid sequence <SEQ ID 132; ORF 036.a>:

a036.pep 1 MLKPCAVYSA CAAVLPARTS SSRRCVSSGR CVNQYSSRAD AIPWRRHSGA 51VAIRCSSDSS GRFCQTIKAA IPPSFSARKT CSDGETSADS NWRCVHADGL 101 QTASSAASAAQSA*TARRMF TGAPSVPPVL WQSRRFCCGR RAARRVPQRR 151 RENRLQPPD* GSRRRSAYRVCLRRADGFPA RTHCRCRLKR RILPAAGCLP 201 PDRPDNRSNG GGSACRTMHK TLRPYVRPQRQGCSFAAAAA RRRHRARVRR 251 LKEYQTALPN LAPRRCRYAV P* m036/a036 85.6%identity over a 270 aa overlap        10        20        30        40        50        60 m036.pepMLKPCAVYSACAAVLPARTSSSRRCVSSGRCVNQYSSRADAIPWRRHSGAVAIRCSSDSS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a036MLKPCAVYSACAAVLPARTSSSRRCVSSGRCVNQYSSRADAIPWRRHSGAVAIRCSSDSS        10        20        30        40        50        60        70        80        90       100       110       120 m036.pepGRFCQTIKAAIPXSFSARKTCSDGETSADSNWRCVHADGLQTASSAASSSQSAQTARRMF|||||||||||| |||||||||||||||||||||||||||||||||||::||| |||||| a036GRFCQTIKAAIPPSFSARKTCSDGETSADSNWRCVHADGLQTASSAASAAQSAXTARRMF        70        80        90       100       110       120       130       140       150       160       170       180 m036.pepTGALSVRPVLWQSGRFCCGRRANRRVRHGRQDNRPWLPMRESRRQSAYPVCLRTAELLPA||| || |||||| |||||||| ||| : |::||   |   |||:||| |||| |: :|| a036TGAPSVPPVLWQSRRFCCGRRAARRVPQRRRENRLQPPDXGSRRRSAYRVCLRRADGFPA       130       140       150       160       170       180       190       200       210       220       230       240 m036.pepRTRCLCRLKRRIPPAAGCLPPARPDNRSNGGSSAYRTMHKTLRPYERPXRQGCSFAAAAA||:| ||||||| |||||||| |||||||||:|| |||||||||| || ||||||||||| a036RTHCRCRLKRRILPAAGCLPPDRPDNRSNGGGSACRTMHKTLRPYVRPQRQGCSFAAAAA       190       200       210       220       230       240       250       260       270 m036.pep RRRHRARVRRLRGYQTALPNPELHRCRYAVRX|||||||||||: |||||||   :|||||| a036 RRRHRARVRRLKEYQTALPNLAPRRCRYAVPX       250       260       270Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 036 shows 74.9% identity over a 271 aa overlap with a predicted ORF(ORF 036.ng) from N. gonorrhoeae:

m036/g036         10        20        30        40        50        60m036.pep MLKPCAVYSACAAVLPARTSSSRRCVSSGRCVNQYSSRADAIPWRRHSGAVAIRCSSDSS||||| |||||||:|||||||||||| ||||: |||||||| | |||||||||||||||| g036MLKPCLVYSACAAALPARTSSSRRCVPSGRCAYQYSSRADATPRRRHSGAVAIRCSSDSS        10        20        30        40        50        60        70        80        90       100       110       120 m036.pepGRFCQTIKAAIPXSFSARKTCSDGETSADSNWRCVHADGLQTASSAASSSQSAQTARRMF|||||||||||  |||||||||||||||||||||||||||||:|||||::||   | ||| g036GRFCQTIKAAILPSFSARKTCSDGETSADSNWRCVHADGLQTVSSAASAAQSDGEAGRMF        70        80        90       100       110       120       130       140       150       160       170       180 m036.pepTGALSVRPVLWQSGRFCCGRRANRRVRHGRQDNRPWLPMRESRRQSAYPVCLRTAELLPA   :|| ||||||||||||||| ||| :  :|:|     ||:||:||| |||| |: :|: g036MFVPSVPPVLWQSGRFCCGRRAVRRVPRQLRDSRRRGRARENRRRSAYRVCLRRADGFPV       130       140       150       160       170       180       190       200       210       220       230       240 m036.pepRTRCLCRLKRRIPPAAGCLPPARPDNRSNGGSSAYRTMHKTLRPYERPXRQGCSFAAAAA||:| |||||| | :: |||| | |||||||:|| || ||||||| || |: |||||||| g036RTHCRCRLKRRTPRGGQCLPPYRLDNRSNGGGSACRTTHKTLRPYARPQRRVCSFAAAAA       190       200       210       220       230       240       250       260       270 m036.pep RRRHRARVRRLRGYQTALPNPELHRCRYAVRX||||||   ||:: :|||||   :|||||||| g036 RRRHRAWGCRLKACRTALPNLAPRRCRYAVRX       250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 133>:

m036-1.seq 1 ATGCTGAAGC CGTGCGCCGT GTACAGTGCC TGTGCGGCGG TGTTGCCTGC 51ACGGACTTCG AGCAGCAGGC GTTGCGTGTC TTCGGGCAGA TGTGTGAACC 101 AATATTCGAGCAGGGCGGAC GCAATTCCTT GGCGGCGGCA TTCGGGCGCG 151 GTGGCAATCA GGTGCAGTTCGGATTCGTCG GGCAGGTTCT GCCAAACGAT 201 AAAGGCGGCA ATCCCGCCGT CTTTTTCCGCAAGGAAAACC TGTTCGGACG 251 GCGAAACCAG TGCGGACTCA AATTGGCGTT GCGTCCATGCGGACGGGTTG 301 CAGACGGCAT CGAGTGCGGC CAGCTCCTCA CAATCGGCAC AAACGGCACG351 GCGGATGTTC ACGGGCGCGC TCTCCGTTCG GCCTGTTCTT TGGCAGTCAG 401GGCGATTTTG TTGCGGACGT AGAGCAAACC GGCGTGTGCG GCATGGACGG 451 CAGGATAACCGCCCTTGGCT GCCAATGCGA GAAAGTCGGC GGCAGTCGGC 501 ATATCCGGTC TGCCTGAGAACGGCGGAGCT TCTTCCAGCG CGAACGCGCT 551 GCCTATGCCG TCTGAAAAGG CGCATCCCTCCGGCAGCCGG ATGTCTGCCG 601 CCCGCCCGAC CTGATAATCG CTCAAACGGT GGCAGTTCAGCGTATCGAAC 651 CATGCATAAA ACACTTCGCC CATACGAGCG TCCGTAGThis corresponds to the amino acid sequence <SEQ ID 134; ORF 0036-1>:

m036-1.pep 1 MLKPCAVYSA CAAVLPARTS SSRRCVSSGR CVNQYSSRAD AIPWRRHSGA 51VAIRCSSDSS GRFCQTIKAA IPPSFSARKT CSDGETSADS NWRCVHADGL 101 QTASSAASSSQSAQTARRMF TGALSVRPVL WQSGRFCCGR RANRRVRHGR 151 QDNRPWLPMR ESRRQSAYPVCLRTAELLPA RTRCLCRLKR RIPPAAGCLP 201 PARPDNRSNG GSSAYRTMHK TLRPYERP*m036-1/g036 76.8% identity in 228 aa overlap        10        20        30        40        50        60 m036-1.pepMLKPCAVYSACAAVLPARTSSSRRCVSSGRCVNQYSSRADAIPWRRHSGAVAIRCSSDSS||||| |||||||:|||||||||||| ||||: |||||||| | |||||||||||||||| g036MLKPCLVYSACAAALPARTSSSRRCVPSGRCAYQYSSRADATPRRRHSGAVAIRCSSDSS        10        20        30        40        50        60        70        80        90       100       110       120 m036-1.pepGRFCQTIKAAIPPSFSARKTCSDGETSADSNWRCVHADGLQTASSAASSSQSAQTARRMF||||||||||| ||||||||||||||||||||||||||||||:|||||::||   | ||| g036GRFCQTIKAAILPSFSARKTCSDGETSADSNWRCVHADGLQTVSSAASAAQSDGEAGRMF        70        80        90       100       110       120       130       140       150       160       170       180 m036-1.pepTGALSVRPVLWQSGRFCCGRRANRRVRHGRQDNRPWLPMRESRRQSAYPVCLRTAELLPA   :|| ||||||||||||||| ||| :  :|:|     ||:||:||| |||| |: :|: g036MFVPSVPPVLWQSGRFCCGRRAVRRVPRQLRDSRRRGRARENRRRSAYRVCLRRADGFPV       130       140       150       160       170       180       190       200       210       220      229 m036-1.pepRTRCLCRLKRRIPPAAGCLPPARPDNRSNGGSSAYRTMHKTLRPYERPX ||:| |||||| | ::|||| | |||||||:|| || ||||||| || g036RTHCRCRLKRRTPRGGQCLPPYRLDNRSNGGGSACRTTHKTLRPYARPQRRVCSFAAAAA       190       200       210       220       230       240 g036RRRHRAWGCRLKACRTALPNLAPRRCRYAVRX        250       260       270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 135>:

g038.seq 1 ATGACTGATT TCCGCCAAGA TTTCCTCAAA TTCTCCCTCG CCCAAAATGT 51TTTGAAATTC GGCGAATTTA CCACCAAAGC CGGACGGCGG TCGCCCTATT 101 TCTTCAATGCCGGCCTCTTC AACGACGGCG CGTCCACGCT GCAACTGGCA 151 AAATTCTATG CACAATCCATCATTGAAAGC GGCATCCGAT TCGATATGCT 201 GTTCGGCCCC GCCTACAAAG GCATTATTTTGGCGGCGGCA ACCGCGATGA 251 TGCTGGCGGA AAAAGGCGTG AACGTCCCGT TTGCCTACAACCGCAAAGAA 301 GCCAAAGACC GCGGCGAAGG CGGCGTGTTG GTCGGCGCGC CGCTTAAAGG351 GCGCGTGCTG ATTATCGACG ACGTGATTTC CGCCGGCACA TCCGTACGCG 401AATCAATCAA ACTGATTGAA GCGGAGGGTG CAACCCCCGC CGGTGTCGCC 451 ATCGCGCTCGACCGCATGGA AAAAGGCACG GGTAAATTGT CCGCCGTTCA 501 GGAAGTGGAA AAACAATACGGCCTGCCCGT CGCCCCCATC GCCAGCCTGA 551 ACGATTTGTT TATCCTGTTG CAAAACAACCCCGAATTCGG ACAGTTCCTC 601 GAACCCGTCC GCACCTACCG CCGGCAGTAC GGCGTAGAAT AAThis corresponds to the amino acid sequence <SEQ ID 136; ORF 038.ng>:

g038.pep 1 MTDFRQDFLK FSLAQNVLKF GEFTTKAGRR SPYFFNAGLF NDGASTLQLA 51KFYAQSIIES GIRFDMLFGP AYKGIILAAA TAMMLAEKGV NVPFAYNRKE 101 AKDRGEGGVLVGAPLKGRVL IIDDVISAGT SVRESIKLIE AEGATPAGVA 151 IALDRMEKGT GKLSAVQEVEKQYGLPVAPI ASLNDLFILL QNNPEFGQFL 201 EPVRTYRRQY GVE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 137>:

m038.seq 1 ATGACCGATT TCCGCCAAGA TTTCCTCAAA TTCTCCCTCG CCCAAAATGT 51TTTGAAATTC GGCGAATTTA CCACCAAGGC AGGACGGCGG TCGCCCTATT 101 TCTTCAATGCCGGCCTCTTT AACGACGGCT TGTCCACGCT GCAACTGGCA 151 AAATTTTACG CACAATCCATCATTGAAAGC GGCATCCGAT TCGATATGCT 201 GTTCGGTCCC GCCTACAAAG GCATTATTTTGGCGGCGGCA ACCGCGATGA 251 TGCTGGCGGA AAAAGGCGTG AACGTCCCGT TTGCCTACAACCGCAAAGAA 301 GCCAAAGACC ACGGCGAAGG CGGCGTGTTG GTCGGCGCGC CGCTTAAAGG351 GCGCGTGCTG ATTATCGACG ACGTGATTTC CGCCGGCACA TCCGTACGCG 401AATCGATCAA ACTGATTGAA GCGGAGGGTG CAACCCCcGC CGGTGTCGCC 451 ATCGCGCTCGATCGCATGGA AAAAGGCACG GGTGAATTGA GCGCGGTTCA 501 GGAAGTGGAr AAACAATACGGkCTGCCCGT CGCCCCCATC GCCAGCCTGA 551 ACGATTTGTT TATTCTGTTG CAAAACAACCCCGAATTCGG ACAGTTCCTC 601 GAACCCGTCC GAGCCTACCG TCGGCAGTAC GGCGTAGAAT AAThis corresponds to the amino acid sequence <SEQ ID 138; ORF 038>:

m038.pep 1 MTDFRQDFLK FSLAQNVLKF GEFTTKAGRR SPYFFNAGLF NDGLSTLQLA 51KFYAQSIIES GIRFDMLFGP AYKGIILAAA TAMMLAEKGV NVPFAYNRKE 101AKDHGEGGVL VGAPLKGRVL IIDDVISAGT SVRESIKLIE AEGATPAGVA 151IALDRMEKGT GELSAVQEVE KQYGLPVAPI ASLNDLFILL QNNPEFGQFL 201EPVRAYRRQY GVE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 139>:

a038.seq 1 ATGACCGATT TCCGCCAAGA TTTCCTCAAA TTCTCCCTCG CCCAAAATGT 51TTTGAAATTC GGCGAATTCA CCACCAAAGC CGGACGGCGG TCGCCCTATT 101TCTTCAATGC CGGCCTCTTT AACGACGGCT TGTCCACGCT GCAACTGGCA 151AAATTTTACG CACAATCCAT CATTGAAAGC GGCATCCGAT TCGATATGCT 201GTTCGGCCCC GCCTACAAAG GCATTATTTT GGCGGCGGCA ACCGCGATGA 251TGCTGGCGGA AAAAGGCGTG AACGTCCCGT TTGCCTACAA CCGCAAAGAA 301GCCAAAGACC ACGGCGAAGG CGGCGTGTTG GTCGGCGCGC CGCTTAAAGG 351GCGCGTGCTG ATTATCGACG ACGTGATTTC CGCCGGCACA TCCGTACGCG 401AATCGATCAA ACTGATTGAA GCGGAGGGTG CAACCCCCGC CGGTGTCGCC 451ATCGCGCTCG ACCGCATGGA AAAAGGCACG GGTGAATTGA GCGCGGTTCA 501GGAAGTGGAA AAACAATACG GCCTGCCCGT CGCCCCCATC GCCAGCCTGA 551ACGATTTGTT TATTCTGTTG CAAAACAACC CCGAATTCGG ACAGTTCCTC 601GAACCCGTCC GAGCCTACCG TCGGCAGTAC GGCGTAGAAT AAThis corresponds to the amino acid sequence <SEQ ID 140; ORF 038.a>:

a038.pep 1 MTDFRQDFLK FSLAQNVLKF GEFTTKAGRR SPYFFNAGLF NDGLSTLQLA 51KFYAQSIIES GIRFDMLFGP AYKGIILAAA TAMMLAEKGV NVPFAYNRKE 101AKDHGEGGVL VGAPLKGRVL IIDDVISAGT SVRESIKLIE AEGATPAGVA 151IALDRMEKGT GELSAVQEVE KQYGLPVAPI ASLNDLFILL QNNPEFGQFL 201EPVRAYRRQY GVE* m038/a038 100.0% identity over a 213 aa overlap        10        20        30        40        50        60 m038.pepMTDFRQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNAGLFNDGLSTLQLAKFYAQSIIES|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a038MIDFRQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNAGLFNDGLSTLQLAKFYAQSIIES        10        20        30        40        50        60        70        80        90       100       110       120 m038.pepGIRFDMLFGPAYKGIILAAATAMMLAEKGVNVPFAYNRKEAKDHGEGGVLVGAPLKGRVL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a038GIRFDMLFGPAYKGIILAAATAMMLAEKGVNVPFAYNRKEAKDHGEGGVLVGAPLKGRVL        70        80        90       100       110       120       130       140       150       160       170       180 m038.pepIIDDVISAGTSVRESIKLIEAEGATPAGVAIALDRMEKGTGELSAVQEVEKQYGLPVAPI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a038IIDDVISAGTSVRESIKLIEAEGATPAGVAIALDRMEKGTGELSAVQEVEKQYGLPVAPI       130       140       150       160       170       180       190       200       210 m038.pepASLNDLFILLQNNPEFGQFLEPVRAYRRQYGVEX ||||||||||||||||||||||||||||||||||a038 ASLNDLFILLQNNPEFGQFLEPVRAYRRQYGVEX        190       200       210Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 038 shows 98.1% identity over a 213 aa overlap with a predicted ORF(ORF 038.ng) from N. gonorrhoeae:

m038/g038         10        20        30        40        50        60m038.pep MTDFRQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNAGLFNDGLSTLQLAKFYAQSIIES||||||||||||||||||||||||||||||||||||||||||| |||||||||||||||| g038MIDFRQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNAGLFNDGASTLQLAKFYAQSIIES        10        20        30        40        50        60        70        80        90       100       110       120 m038.pepGIRFDMLFGPAYKGIILAAATAMMLAEKGVNVPFAYNRKEAKDHGEGGVLVGAPLKGRVL|||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||| g038GIRFDMLFGPAYKGIILAAATAMMLAEKGVNVPFAYNRKEAKDRGEGGVLVGAPLKGRVL        70        80        90       100       110       120       130       140       150       160       170       180 m038.pepIIDDVISAGTSVRESIKLIEAEGATPAGVAIALDRMEKGTGELSAVQEVEKQYGLPVAPI|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| g038IIDDVISAGTSVRESIKLIEAEGATPAGVAIALDRMEKGIGKLSAVQEVEKQYGLPVAPI       130       140       150       160       170       180       190       200       210 m038.pepASLNDLFILLQNNPEFGQFLEPVRAYRRQYGVEX ||||||||||||||||||||||||:|||||||||g038 ASLNDLFILLQNNPEFGQFLEPVRTYRRQYGVEX        190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 141>:

g039.seq 1 ATGCCGTCCG AACCACCTGC CGCTTCAGAC GGCATCAAAC CGACACACAC 51CGAGAAAACA TCATGCCCGC CTGTTTCTGT CCGCACTGCA AAACCCGCCT 101CTGGGTCAAA GAAAcccagC TCAAcgtCgC ccaagGCTTC GTCGTCTgcc 151aaAAAtgcga agGGCTgttt aaAgccaaaG accAtctggc aaGcacGAAA 201gaacctatat tcaacgattg gcccgaagct gtttcgggat gTcaaaCTCG 251TCcaccgcaT cggcacgcac gccattagca aGAaacagat gtcccgcgac 301gaaatCgccg atatcctcaa cggcggtaca acCCTGCACG ATACGCCGCC 351CGCAACCGCC GCTGCCGCac ctGCCGCCGC ACCGCaggTT TCCGTACCGC 401CCGCCCGTCA GGAAGGGCTC AACTGGACTA TTGCAACCCT GTTCGCACTT 451ATCGTCCTCA TTATGCAGCT TTCCTACCTC TTCATCCTAT GAThis corresponds to the amino acid sequence <SEQ ID 142; ORF 039.ng>:

g039.pep 1 MPSEPPAASD GIKPTHTEKT SCPPVSVRTA KPASGSKKPS STSPKASSSA 51KNAKGCLKPK TIWQARKNLY STIGPKLFRD VKLVHRIGTH AISKKQMSRD 101EIADILNGGT TLHDTPPATA AAAPAAAPQV SVPPARQEGL NWTIATLFAL 151IVLIMQLSYL FIL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 143>:

m039.seq 1 ATGCCGTCCG AACCGCCTTA CGCCTCAGAC GGCATCAAAC CTGACACACA 51CGAGGAAATA CCATGCCCGC CTGTTTCTGC CCCCACTGCA AAACCCGTCT 101CTGGGTCAAA GAAACCCAAC TCAATGTCGC CGnnnnnnnn nnnnnnnnnn 151nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 201nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnCCC GAGGCTGTTT 251CGGATGTCAA ACTCGTTCAC CGTATCGGCA CGCGCGCCAT CGGCAAGAAA 301CAGATTTCCC GTGACGAAAT CGCCGGCATC CTCAACGGCG GTACAACCCA 351GCCCGATATT CCGCCCGCAA CCGCCGCCAC CCCTGCTGCC GCACCGCAGG 401TTACCGTACC GCCCGCCGCG CCCGCCCGTC AGGATGGGTT CAACTGGACG 451ATTGCAACCC TGTTTGCCCT TATCGTCCTC ATTATGCAGC TTTCCTACCT 501CGTCATCCTA TGAThis corresponds to the amino acid sequence <SEQ ID 144; ORF 039>:

m039.pep 1 MPSEPPYASD GIKPDTHEEI PCPPVSAPTA KPVSGSKKPN SMSPXXXXXX 51XXXXXXXXXX XXXXXXXXXX XXXXXXXXXP EAVSDVKLVH RIGTRAIGKK 101QISRDEIAGI LNGGTTQPDI PPATAATPAA APQVTVPPAA PARQDGFNWT 151IATLFALIVL IMQLSYLVIL *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 145>:

a039.seq 1 ATGCCGTCTG AACCGCCTTA CGCCTCAGAC GGCATCAAAC CTGACACACA 51CGAGGAAATA CCATGCCCGC CTGTTTCTGC CCCCACTGCA AAACCCGTCT 101CTGGGTCAAA GAAACCCAAC TCAATGTCGC CCAAGGCTTC GTCGTCTGCC 151AAAAATGCGA AGGAATGTTT AAAGCCAAAG ACCATCTGGC AAGCACGAAA 201GAACCCATAT TCAACGATT. TGCCCGAAGC TGTTTCGGAT GTCAAACTCG 251TTCACCGCAT CGGCACGAGC GCCATCGGCA AGAAACAGAT TTCCCGTGAC 301GAAATCGCCG GCATCCTCAA CGGCGGCACA ACCCAGCCCG ATATTCCGCC 351CGCAACCGCC GCCACCCCTG CTGCCGCACC GCAGGTTACC GTACCGCCCG 401CCGCGCCCGC CCGTCAGGAT GGGTTCAACT GGACGATTGC AACCCTGTTT 451GCCCTTATCG TCCTCATTAT GCAGCTTTCC TACCTCGTCA TCCTATGAThis corresponds to the amino acid sequence <SEQ ID 146; ORF 039.a>:

a039.pep 1 MPSEPPYASD GIKPDTHEEI PCPPVSAPTA KPVSGSKKPN SMSPKASSSA 51KNAKECLKPK TIWQARKNPY STIXPEAVSD VKLVHRIGTS AIGKKQISRD 101EIAGILNGGT TQPDIPPATA ATPAAAPQVT VPPAAPARQD GFNWTIATLF 151ALIVLIMQLS YLVIL* m039/a039 79.4% identity over a 170 aa overlap        10        20        30        40        50        60 m039.pepMPSEPPYASDGIKPDTHEEIPCPPVSAPTAKPVSGSKKPNSMSPXXXXXXXXXXXXXXXX|||||||||||||||||||||||||||||||||||||||||||| a039MPSEPPYASDGIKPDTHEEIPCPPVSAPTAKPVSGSKKPNSMSPKASSSAKNAKECLKPK        10        20        30        40        50        60        70        80        90       100       110       120 m039.pepXXXXXXXXXXXXXXXXXXXPEAVSDVKLVHRIGTRAIGKKQISRDEIAGILNGGTTQPDI:          : |     ||||||||||||||| ||||||||||||||||||||||||| a039TIWQARKNPYSTIX-----PEAVSDVKLVHRIGTSAIGKKQISRDEIAGILNGGTTQPDI        70             80        90       100       110       130       140       150       160       170 m039.pepPPATAATPAAAPQVTVPPAAPARQDGFNWTIATLFALIVLIMQLSYLVILX||||||||||||||||||||||||||||||||||||||||||||||||||| a039PPATAATPAAAPQVTVPPAAPARQDGFNWTIATLFALIVLIMQLSYLVILX  120       130       140       150       160Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 039 shows 60.8% identity over a 171 aa overlap with a predicted ORF(ORF 039.ng) from N. gonorrhoeae:

m039/g039         10        20        30        40        50        60m039.pep MPSEPPYASDGIKPDTHEEIPCPPVSAPTAKPVSGSKKPNSMSPXXXXXXXXXXXXXXXX|||||| |||||||   |:  |||||: ||||:||||||:| || g039MPSEPPAASDGIKPTHTEKTSCPPVSVRTAKPASGSKKPSSTSPKASSSAKNAKGCLKPK        10        20        30        40        50        60        70        80        90       100       110       120 m039.pepXXXXXXXXXXXXXXXXXXXPEAVSDVKLVHRIGTRAIGKKQISRDEIAGILNGGTTQPDI:          :       |:   ||||||||||:||:|||:|||||| |||||||  | g039TIWQARKNLYSTIG-----PKLFRDVKLVHRIGTHAISKKQMSRDEIADILNGGTTLHDT        70             80        90       100       110        130       140       150       160       170 m039.pepPPATAAT-PAAAPQVTVPPAAPARQDGFNWTIATLFALIVLIMQLSYLVILX||||||: |||||||:||||   ||:|:|||||||||||||||||||| ||| g039PPATAAAAPAAAPQVSVPPA---RQEGLNWTIATLFALIVLIMQLSYLFILX  120       130          140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 147>:

g040.seq 1 ATGAACGCGC CCGACAGCTT TGTCGCCCAC TTCCGCGAAG CCGCCCCCTA 51CATCCGCCAA ATGCGCGGCA CGACACTGGT CGCCGGCATA GAcggCCGCC 101TGCTCGAAGG CGGCACCTTA AATAAGCTCG CCGCCGACAT CGGGCTGTTG 151TCGCAACTGG GCATCCGACT CGTCCTCATC CACGGCGCGT ACCACTTCCT 201CGAccgCCTC GCCGCCGCGC AAGgccGCAC GCCGCATTAT TGCCGgggtt 251tGCGCGTTAC CGACGaAACc tcGctcgGAC AGGCGCAGCA GtttGCCGGC 301AccgTCCGCA GCCGTTTTGA agcCGCATTG tgcggcagCG tttcaggatt 351cgcgCGCGCG CCTTCCGTCC CGCTCGTAtc gggcaacttc ctgacCGCCC 401GTCcgatggg cgtgattgac ggaACCGata tggaatacgc gggggttatc 451cgcaaaaccg ACACCGCCGC CCTCCGTTTC CAACTCGACG CGGGCAATAT 501CGTCTGGATG CCGCCGCTCG GGCATTCCTA CGGCGGCAAA ACCTTCAATC 551TCGATATGGT GCAGGCCGCC GCTTCCGTCG CCGTCTCGCT TCAGGCCGAA 601AAACTCGTTT ACCTGACCCT TTCAGACGGC ATTTCCCGCC CCGACGGCAC 651GCTCGCCGAA ACCCTCTCGG CACAGGAAGC GCAATCGCTG GCGGAACACG 701CCGCCAGCGA AACCCGACGA CTGATTTCGT CCGCCGTTGC CGCGCTCGAA 751GGCGGCGTGC ATCGCGTCCA AATCCTCAAC GGGGCCGCCG ACGGCAGCCT 801GCTGCAAGAA CTCTTCACCC GCAACGGCAT CGGCACGTCC ATTGCCAAAG 851AAGCCTTCGT CTCCATCCGG CAGGCGCACA GCGGCGACAT CCCGCACATC 901GCCGCCCTCA TCCGCCCGCT GGAAGAACAG GGCGTCCTAT TGCACCGCAG 951CCGCGAATAC CTCGAAAACC ACATTTCCGA ATTTTCCATC CTCGAACACG 1001ACGGCGACCT GTACGGCTGT GCCGCACTCA AAACCTTTGC CGAAGCCGAT 1051TGCGGCGAAA TCGCCTGCCT TGCCGTCTCG CCGCAGGCAC AGGACGGCGg 1101ctACGGCGAA CGCCTGCTTG CCCACATTAT CGATAAGGCG CGCGGCATAG 1151GCATAAGCAG GCTGTTCGCA CTGTCCACAA ATACCGGCGA ATGGTTTGCC 1201GAACGCGGCT TTCAGACGGC ATCGGAAGAC GAGCTGCCCG AAACGCGGCG 1251CAAAGACTAC CGCAGCAACG GACGAAACCC GCATATTCTG GTGCGTCGCC 1301 TGCACCGCTG AThis corresponds to the amino acid sequence <SEQ ID 148; ORF 040.ng>:

g040.pep 1 MNAPDSFVAH FREAAPYIRQ MRGTTLVAGI DGRLLEGGTL NKLAADIGLL 51SQLGIRLVLI HGAYHFLDRL AAAQGRTPHY CRGLRVTDET SLGQAQQFAG 101TVRSRFEAAL CGSVSGFARA PSVPLVSGNF LTARPMGVID GTDMEYAGVI 151RKTDTAALRF QLDAGNIVWM PPLGHSYGGK TFNLDMVQAA ASVAVSLQAE 201KLVYLTLSDG ISRPDGTLAE TLSAQEAQSL AEHAASETRR LISSAVAALE 251GGVHRVQILN GAADGSLLQE LFTRNGIGTS IAKEAFVSIR QAHSGDIPHI 301AALIRPLEEQ GVLLHRSREY LENHISEFSI LEHDGDLYGC AALKTFAEAD 351CGEIACLAVS PQAQDGGYGE RLLAHIIDKA RGIGISRLFA LSTNTGEWFA 401ERGFQTASED ELPETRRKDY RSNGRNPHIL VRRLHR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 149>:

m040.seq 1 ATGAGCGCGC CCGACCTCTT TGTCGCCCAC TTCCGCGAAG CCGTCCCCTA 51CATCCGCCAA ATGCGCGGCA AAACGCTGGT CGCCGGCATA GACGACCGCC 101TGCTCGAAGG TGATACCTTA AACAAGCTCG CCGCCGACAT CGGGCTGTTG 151TCGCAACTGG GCATCAGGCT CGTCCTCATC CACGGCGCGC GCCACTTCCT 201CGACCGCCAC GCCGCCGCTC AAGGCCGCAC GCCGCATTAT TGCCGGGGCT 251TGCGCGTTAC CGACGAAACC TCGCTCGAAC AGGCGCAgCA GTTTGCCGGC 301ACCGTCCGCA GCCGTTTTGA AGCCGCATTG TGCGGCAGCG TTTCCGGGTT 351CGCGCGCGCG CCTTCCGTCC CGCTCGTATC GGGCAACTTC CTGACCGCCC 401GTCCGATAGG TGTGATTGAC GGAACCGATA TGGAATACGC GGGCGTTATC 451CGCAAAACCG ACACCGCCGC CCTCCGTTTC CAACTCGACG CGGGCAATAT 501CGTCTGGCTG CCGCCGCTCG GACATTCCTA CAGCGGCAAG ACCTTCTATC 551TCGATATGCT TCAAACCGCC GCCTCCGCCG CCGTCTCGCT TCAGGCCGAA 601AAACTCGTTT ACCTGACCCT TTCAGACGGC ATTTCCCGCC CCGACGGCAC 651GCTCGCCGAA ACCCTCTCGG CACAGGAAGC GCAATCGCTG GCGGAACACG 701CCGGCGGGCA AACGCGACGG CTGATTTCGT CCGCCGAACT CTTCACCCGC 751AACGGCATCG GCACGTCCAT TGCCAAAGAA GCCTTCGTCT CCATCCGGCA 801rGCGCAywgG G.CGACATCC CGCACATCGC CGCCCTCATC CGCCCGCTGG 851AAGAACAGGG CATCCTGCTG CACCGCAs.c GCGAATACCT CGAAAACCAC 901ATTTCCGAAT TTTCCATCCT CGAACACGAC GGCAACCTGT ACGGTTGCGC 951CGCCCTGAAA ACCTTTGCCG AAGCCGATTG CGGCGAAATC GCCTGCCTTG 1001CCGTCTCGCC GCag.cACAG GACGGCGGCT ACGGCGAACG CnTGCTTGCC 1051CACATTATCG ATAAGGCGCG CGGCATAGGC ATAAGCAGGC TGTTCGCACT 1101GTCCACAAAT ACCGGCGAAT GGTTTGCCGA ACGCGGCTTT CAGACGGCAT 1151CGGAAGACGA GTTGCCCGAA ACGCGGCGCA AAGACTACCG CAGCAACGGA 1201CGGAACTCGC ATATTCTGGT ACGTCGCCTG CACCGCTGAThis corresponds to the amino acid sequence <SEQ ID 150; ORF 040>:

m040.pep 1 MSAPDLFVAH FREAVPYIRQ MRGKTLVAGI DDRLLEGDTL NKLAADIGLL 51SQLGIRLVLI HGARHFLDRH AAAQGRTPHY CRGLRVTDET SLEQAQQFAG 101TVRSRFEAAL CGSVSGFARA PSVPLVSGNF LTARPIGVID GTDMEYAGVI 151RKTDTAALRF QLDAGNIVWL PPLGHSYSGK TFYLDMLQTA ASAAVSLQAE 201KLVYLTLSDG ISRPDGTLAE TLSAQEAQSL AEHAGGQTRR LISSAELFTR 251NGIGTSIAKE AFVSIRQAHX XDIPHIAALI RPLEEQGILL HRXREYLENH 301ISEFSILEHD GNLYGCAALK TFAEADCGEI ACLAVSPQXQ DGGYGERXLA 351HIIDKARGIG ISRLFALSTN TGEWFAERGF QTASEDELPE TRRKDYRSNG 401RNSHILVRRL HR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 151>:

a040.seq 1 ATGATCGTGC CCGACCTCTT TGTCGCCCAC TTCCGCGAAG CCGCCCCCTA 51CATCCGCCAA ATGCGCGGCA AAACGCTGGT CGCCGGCATA GACGACCGCC 101 TGCTCGAAGGTGATACCTTA AACAAGTTCG CCGCCGACAT CGGGCTTTTG 151 TCGCAACTGG GCATCAGGCTCGTCCTCATC CACGGCGCGC GCCACTTCCT 201 CGACCGCCAC GCCGCCGCGC AAGGCCGCACGCCGCATTAT TGCCGGGGCT 251 TGCGCGTTAC CGACGAAACC TCGCTCGAAC AGGCGCAGCAGTTTGCCGGC 301 ACCGTCCGCA GCCGTTTTGA AGCCGCATTG TGCGGCAGCG TTTCCGGGTT351 CGCGCGCGCG CCTTCCGTCC CGCTCGTATC GGGCAACTTC CTGACCGCCC 401GTCCGATAGG TGTGATTGAC GGAACCGATA TGGAATACGC GGGCGTTATC 451 CGCAAAACCGACACCGCCGC CCTCCGTTTC CAACTCGACG CGGGCAATAT 501 CGTCTGGCTG CCGCCGCTCGGACATTCCTA CAGCGGCAAG ACCTTCCATC 551 TCGATATGCT TCAAACCGCC GCCTCCGTCGCCGTCTCGCT TCAGGCCGAA 601 AAACTCGTTT ACCTGACCCT TTCAGACGGC ATTTCCCGCCCCGACGGCAC 651 GCTCGCCGTA ACCCTCTCGG CACAGGAAGC GCAATCGCTG GCGGAACACG701 CCGGCGGCGA AACGCGACGG CTGATTTCGT CCGCCGTTGC CGCGCTCGAA 751GGCGGCGTGC ATCGCGTCCA AATCCTCAAC GGAGCCGCCG ACGGCAGCCT 801 GCTGCAAGAACTCTTCACCC GCAACGGCAT CGGCACGTCC ATTGCCAAAG 851 AAGCCTTCGT CTCCATCCGGCAGGCGCACA GCGGCGACAT CCCGCACATT 901 GCCGCCCTCA TCCGCCCGCT GGAAGAACAGGGCATCCTGC TGCACCGCAG 951 CCGCGAATAC CTCGAAAACC ACATTTCCGA ATTTTCCATCCTCGAACACG 1001 ACGGCAACCT GTACGGTTGC GCCGCCCTGA AAACCTTTGC CGAAGCCGAT1051 TGCGGCGAAA TCGCCTGCCT TGCCGTCTCG CCGCAGGCAC AGGACGGCGG 1101CTACGGCGAA CGCCTGCTTG CCCACATTAT CGATAAGGCG CGCGGCATAG 1151 GCATAAGCAGGCTGTTCGCA CTGTCCACAA ATACCGGCGA ATGGTTTGCC 1201 GAACGCGGCT TTCAGACGGCATCGGAAGAC GAGTTGCCCG AAACGCGGCG 1251 CAAAGACTAC CGCAGCAACG GACGGAACTCGCATATTCTG GTGCGTCGCC 1301 TGCACCGCTG AThis corresponds to the amino acid sequence <SEQ ID 152; ORF 040.a>:

a040.pep 1 MIVPDLFVAH FREAAPYIRQ MRGKTLVAGI DDRLLEGDTL NKFAADIGLL 51SQLGIRLVLI HGARHFLDRH AAAQGRTPHY CRGLRVTDET SLEQAQQFAG 101 TVRSRFEAALCGSVSGFARA PSVPLVSGNF LTARPIGVID GTDMEYAGVI 151 RKTDTAALRF QLDAGNIVWLPPLGHSYSGK TFHLDMLQTA ASVAVSLQAE 201 KLVYLTLSDG ISRPDGTLAV TLSAQEAQSLAEHAGGETRR LISSAVAALE 251 GGVHRVQILN GAADGSLLQE LFTRNGIGTS IAKEAFVSIRQAHSGDIPHI 301 AALIRPLEEQ GILLHRSREY LENHISEFSI LEHDGNLYGC AALKTFAEAD351 CGEIACLAVS PQAQDGGYGE RLLAHIIDKA RGIGISRLFA LSTNTGEWFA 401ERGFQTASED ELPETRRKDY RSNGRNSHIL VRRLHR* m040/a040 91.5% identity in 436aa overlap         10        20        30        40        50        60m040.pep MSAPDLFVAHFREAVPYIRQMRGKTLVAGIDDRLLEGDTLNKLAADIGLLSQLGIRLVLI| :|||||||||||:|||||||||||||||||||||||||||:||||||||||||||||| a040MIVPDLFVAHFREAAPYIRQMRGKTLVAGIDDRLLEGDTLNKFAADIGLLSQLGIRLVLI        10        20        30        40        50        60        70        80        90       100       110       120 m040.pepHGARHFLDRHAAAQGRTPHYCRGLRVTDETSLEQAQQFAGTVRSRFEAALCGSVSGFARA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a040HGARHFLDRHAAAQGRTPHYCRGLRVTDETSLEQAQQFAGTVRSRFEAALCGSVSGFARA        70        80        90       100       110       120       130       140       150       160       170       180 m040.pepPSVPLVSGNFLTARPIGVIDGTDMEYAGVIRKTDTAALRFQLDAGNIVWLPPLGHSYSGK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a040PSVPLVSGNFLTARPIGVIDGTDMEYAGVIRKTDTAALRFQLDAGNIVWLPPLGHSYSGK       130       140       150       160       170       180       190       200       210       220       230       240 m040.pepTFYLDMLQTAASAAVSLQAEKLVYLTLSDGISRPDGTLAETLSAQEAQSLAEHAGGQTRR||:|||||||||:|||||||||||||||||||||||||| ||||||||||||||||:||| a040TFHLDMLQTAASVAVSLQAEKLVYLTLSDGISRPDGTLAVTLSAQEAQSLAEHAGGETRR       190       200       210       220       230       240                               250       260       270 m040.pepLISSA------------------------ELFTRNGIGTSIAKEAFVSIRQAHXXDIPHI|||||                        ||||||||||||||||||||||||  ||||| a040LISSAVAALEGGVHRVQILNGAADGSLLQELFTRNGIGTSIAKEAFVSIRQAHSGDIPHI       250       260       270       280       290       300 280       290       300       310       320       330 m040.pepAALIRPLEEQGILLHRXREYLENHISEFSILEHDGNLYGCAALKTFAEADCGEIACLAVS|||||||||||||||| ||||||||||||||||||||||||||||||||||||||||||| a040AALIRPLEEQGILLHRSREYLENHISEFSILEHDGNLYGCAALKTFAEADCGEIACLAVS       310       320       330       340       350       360 340       350       360       370       380       390 m040.pepPQXQDGGYGERXLAHIIDKARGIGISRLFALSTNTGEWFAERGFQTASEDELPETRRKDY|| |||||||| |||||||||||||||||||||||||||||||||||||||||||||||| a040PQAQDGGYGERLLAHIIDKARGIGISRLFALSTNTGEWFAERGFQTASEDELPETRRKDY       370       380       390       400       410       420 400       410 m040.pep RSNGRNSHILVRRLHRX ||||||||||||||||| a040RSNGRNSHILVRRLHRX        430Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 040 shows 88.3% identity over a 436 aa overlap with a predicted ORF(ORF 040.ng) from N. gonorrhoeae:

m040/g040 m040.pepMSAPDLFVAHFREAVPYIRQMRGKTLVAGIDDRLLEGDTLNKLAADIGLLSQLGIRLVLI 60|:||| ||||||||:|||||||| ||||||| ||||| |||||||||||||||||||||| g040MNAPDSFVAHFREAAPYIRQMRGTTLVAGIDGRLLEGGTLNKLAADIGLLSQLGIRLVLI 60 m040.pepHGARHFLDRHAAAQGRTPHYCRGLRVTDETSLEQAQQFAGTVRSRFEAALCGSVSGFARA 120||| ||||| |||||||||||||||||||||| ||||||||||||||||||||||||||| g040HGAYHFLDRLAAAQGRTPHYCRGLRVTDETSLGQAQQFAGTVRSRFEAALCGSVSGFARA 120m040.pep PSVPLVSGNFLTARPIGVIDGTDMEYAGVIRKTDTAALRFQLDAGNIVWLPPLGHSYSGK180 |||||||||||||||:|||||||||||||||||||||||||||||||||:|||||||:|| g040PSVPLVSGNFLTARPMGVIDGTDMEYAGVIRKTDTAALRFQLDAGNIVWMPPLGHSYGGK 180m040.pep TFYLDMLQTAASAAVSLQAEKLVYLTLSDGISRPDGTLAETLSAQEAQSLAEHAGGQTRR240 || |||:|:|||:|||||||||||||||||||||||||||||||||||||||||:::||| g040TFNLDMVQAAASVAVSLQAEKLVYLTLSDGISRPDGTLAETLSAQEAQSLAEHAASETRR 240m040.pep LISSA------------------------ELFTRNGIGTSIAKEAFVSIRQAHXXDIPHI276 |||||                        ||||||||||||||||||||||||  ||||| g040LISSAVAALEGGVHRVQILNGAADGSLLQELFTRNGIGTSIAKEAFVSIRQAHSGDIPHI 300m040.pep AALIRPLEEQGILLHRXREYLENHISEFSILEHDGNLYGCAALKTFAEADCGEIACLAVS336 |||||||||||:|||| ||||||||||||||||||:|||||||||||||||||||||||| g040AALIRPLEEQGVLLHRSREYLENHISEFSILEHDGDLYGCAALKTFAEADCGEIACLAVS 360m040.pep PQXQDGGYGERXLAHIIDKARGIGISRLFALSTNTGEWFAERGFQTASEDELPETRRKDY396 || |||||||| |||||||||||||||||||||||||||||||||||||||||||||||| g040PQAQDGGYGERLLAHIIDKARGIGISRLFALSTNTGEWFAERGFQTASEDELPETRRKDY 420m040.pep RSNGRNSHILVRRLHRX 413 |||||| |||||||||| g040 RSNGRNPHILVRRLHRX437The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 153>:

g041.seq 1 ATGAGTTCGC CCAAACACAT CGGCTTGCAG GGCGGCAGCA ACGGCGGCCT 51GATTACCGCC GCCGCCTTCG TGCGCGAACC GCAAAGCATC GGTGCGCTGG 101 TGTGCGAAGTACCGCTGACC GATATGATCC GTTATCCGCT GCTGTCCGCC 151 GGTTCAAGTT GGACGGACGAATACGGCAAT CCGCAGAAAT ACGAAGCCTG 201 CAAACGCCGG CTGGGCGAAT TGTCGCCGTATCACAATCTT TCAGACGGCA 251 TCGATTATCC GCCCGCACTC ATTACCACCA GCCTCAGCGACGACCGCGTC 301 CATCCCGCCC ACGCGCTCAA ATTCTACGCC AAACTGCGCG AAACCTCGCC351 GCAATCTTGG CTCTACTCGC CTGACGGCGG CGGCCATACC GGCAACGGCA 401CCCAACGCGA ATCCGCCGAC AAACTCGCCT GCGTGTTGCT GTTTTTGAAA 451 GAATTTTTGGGATAAThis corresponds to the amino acid sequence <SEQ ID 154; ORF 041.ng>:

g041.pep 1 MSSPKHIGLQ GGSNGGLITA AAFVREPQSI GALVCEVPLT DMIRYPLLSA 51GSSWTDEYGN PQKYEACKRR LGELSPYHNL SDGIDYPPAL ITTSLSDDRV 101 HPAHALKFYAKLRETSPQSW LYSPDGGGHT GNGTQRESAD KLACVLLFLK 151 EFLG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 155>:

m041.seq 1 ATCAGTTCGC CCGAACACAT CGGCTTGCAG GGCGGCAGCA ACGGCGGACT 51GATTACTGCC GCCGCCTTCG TGCGCGAACC GCAAAGCATC GGCGCGCTGG 101 TGTGCGAAGTGCCGCTGACC GACATGATCC GTTATCCGCT GCTCTCCGCC 151 GGTTCAAGCT GGACAGACGAATACGGCAAT CCGCAAAAAT ACGAAGTCTG 201 CAAACGCCGG TTGGGCGAAT TGTCGCCGTATCACAATCTT TCAGACGGCA 251 TCGATTATCC GCCCGCGCTC ATTACCACCA GCCTGTCCGACGATCGCGTC 301 CATCCCGCCC ACGCGCTCAA GTTCTACGCC AAACTGCGCG AAACCTCCGC351 GCAATCTTGG CTCTACTCGC CTGACGGCGG CGGCCATACC GGCAACGGCA 401CCCAACGCGA ATCCGCCGAC GAACTCGCCT GCGTCTTGCT GTTTTTGAAA 451 GAGTTTTTGGGCTAAThis corresponds to the amino acid sequence <SEQ ID 156; ORF 041>:

m041.pep 1 ISSPEHIGLQ GGSNGGLITA AAFVREPQSI GALVCEVPLT DMIRYPLLSA 51GSSWTDEYGN PQKYEVCKRR LGELSPYHNL SDGIDYPPAL ITTSLSDDRV 101 HPAHALKFYAKLRETSAQSW LYSPDGGGHT GNGTQRESAD ELACVLLFLK 151 EFLG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 157>:

a041.seq 1 ATCAGTTCGC CCGAACACAT CGGCTTGCAG GGCGGCAGCA ACGGCGGACT 51GATTACTGCC GCCGCCTTCG TGCGCGAACC GCAAAGCATA GGCGCGCTGG 101 TGTGCGAAGTGCCGCTGACC GACATGATCC GTTATCCGCT GCTCTCCGCC 151 GGTTCAAGCT GGACAGACGAATACGGCAAT CCGCAAAAAT ACGAAGTCTG 201 CAAACGCCGG TTGGGCGAAT TGTCGCCGTATCACAATCTT TCAGACGGCA 251 TCGATTATCC GCCCGCGCTC ATTACCACCA GCCTGTCCGACGATCGCGTC 301 CATCCCGCCC ACGCGCTCAA GTTCTACGCC AAACTGCGCG AAACCTCGCC351 GCAATCTTGG CTCTACTCGC CTGACGGCGG CGGCCATACC GGCAACGGCA 401CGCAGCGCGA AGCCGCCGAC GAACTCGCCT GCGTGTTGCT GTTTTTGAAA 451 GAGTTTTTGGGCTAAThis corresponds to the amino acid sequence <SEQ ID 158; ORF 041.a>:

a041.pep 1 ISSPEHIGLQ GGSNGGLITA AAFVREPQSI GALVCEVPLT DMIRYPLLSA 51GSSWTDEYGN PQKYEVCKRR LGELSPYHNL SDGIDYPPAL ITTSLSDDRV 101 HPAHALKFYAKLRETSPQSW LYSPDGGGHT GNGTQREAAD ELACVLLFLK 151 EFLG* m041/a041 98.7%identity over a 154 aa overlap        10        20        30        40        50        60 m041.pepISSPEHIGLQGGSNGGLITAAAFVREPQSIGALVCEVPLTDMIRYPLLSAGSSWTDEYGN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a041ISSPEHIGLQGGSNGGLITAAAFVREPQSIGALVCEVPLTDMIRYPLLSAGSSWTDEYGN        10        20        30        40        50        60        70        80        90       100       110       120 m041.pepPQKYEVCKRRLGELSPYHNLSDGIDYPPALITTSLSDDRVHPAHALKFYAKLRETSAQSW|||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||| a041PQKYEVCKRRLGELSPYHNLSDGIDYPPALITTSLSDDRVHPAHALKFYAKLRETSPQSW        70        80        90       100       110       120       130       140       150 m041.pepLYSPDGGGHTGNGTQRESADELACVLLFLKEFLGX |||||||||||||||||:|||||||||||||||||a041 LYSPDGGGHTGNGTQREAADELACVLLFLKEFLGX        130       140       150Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 041 shows 96.8% identity over a 154 aa overlap with a predicted ORF(ORF 041.ng) from N. gonorrhoeae:

m041/g041         10        20        30        40        50        60m041.pep ISSPEHIGLQGGSNGGLITAAAFVREPQSIGALVCEVPLTDMIRYPLLSAGSSWTDEYGN:|||:||||||||||||||||||||||||||||||||||||||||||||||||||||||| g041MSSPKHIGLQGGSNGGLITAAAFVREPQSIGALVCEVPLTDMIRYPLLSAGSSWTDEYGN        10        20        30        40        50        60        70        80        90       100       110       120 m041.pepPQKYEVCKRRLGELSPYHNLSDGIDYPPALITTSLSDDRVHPAHALKFYAKLRETSAQSW|||||:|||||||||||||||||||||||||||||||||||||||||||||||||| ||| g041PQKYEACKRRLGELSPYHNLSDGIDYPPALITTSLSDDRVHPAHALKFYAKLRETSPQSW        70        80        90       100       110       120       130       140       150 m041.pepLYSPDGGGHTGNGTQRESADELACVLLFLKEFLGX ||||||||||||||||||||:||||||||||||||g041 LYSPDGGGHTGNGTQRESADKLACVLLFLKEFLGX        130       140       150The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 159>:

g041-1.seq 1 ATGAAATCCT ACCCCGACCC CTACCGCCAT TTTGAAAACC TCGATTCCGC 51CGAAACGCAA AACTTCGCTG CTGAAGCGAA TGCCGAAACG CGCGCGCGTT 101 TTTTAAACAACGACAAGGCG CGCGCACTTT CAGACGGCAT TTTGAATCAA 151 ATGCAGGACA CGCGGCAGATTCCGTTTTGT CAGGAACACC GCGCGCGGAT 201 GTACCATTTC CATCAGAATG CGGAATATCCGAAGGGCGTG TACCGCATGT 251 GTACGGCGGC GACCTACCGT TCCGGCTATC CCGAGTGGAAAATCCTGTTT 301 TCGGTGGCGG ATTTCGATGA GTTGCTCGGC GACGATGTGT ATTTGGGCGG351 CGTGTCGCAC TTGGTGGAGC AGCCCAACCG CGCGCTGCTG ACTTTGAACA 401AATCGGGCGG CGATACGGCG TATACGCTGG AAGTGGATTT GGAAGCAGGG 451 GAATTGGTAGAGGGCGGTTT TCACTTTCCG GCAGGCAAAA ACCATGTGTC 501 GTGGCGCGAT GAAAACAGCGTGTGGGTGTG TCCGGCTTGG GACGAACGCC 551 AGTTGACCGA ATCGGGCTAT CCGCGCGAAGTGTGGCTGGT GGAACGCGGC 601 AAGAGTTTCG AGGAAAGCCT GCCGGCGTAC CAAATCGATAAAGGCGCGAT 651 GATGGTAAAC GCGTGGCGTT ACCTCGATCC GCAGGGTTCG CCGATTGATT701 TGATTGAAGC GTCGGACGGT TTTTACACCA AGACGTATTT GCAGGTGTCG 751TCCGAAGGCG GGGCGAAACC GTTGAACCTG CCTAATGATT GCGATGTGGT 801 CGGCTATCTGGCGGGACATC TTTTGCTGAC GCTGCGCAAG GACTGGCACC 851 GCGCGAACCA AAGCTATCCGAGTGGCGCGT TGGTGGCGGT GAAACTGAAT 901 CGGGGCGAAC TCGGGGCGGC GCAGCTTTTGTTTGCGCCCG ATGAAACGCA 951 GGCATTGGAA AGCGTGGAAA CGACCAAGCG TTTTGTGGTGGCAAGCCTGC 1001 TGGAGAATGT ACAAGGCCGT CTGAAAGCGT GGCGGTTTGC CGACAGCAAA1051 TGGCAGGAAG CCGAGTTGCC GCACCTGCCC TCGGGCGCGT TGGAAATGAC 1101CGACCAACCG TGGGGCGGCG ACGTGGTTTA TCTTGCCGCC AGCGATTTCA 1151 CCACGCCGCTGACGCTGTTT GCGCTGGATT TGAACGTGAT GGAACTGACC 1201 GTCATGCGCC TCCAGCCGCAGCAGTTTGTT TCAGACGGCA TCGAAGTGCG 1251 GCAGTTTTGG GCGGTGTCGT CCGACGGCGAACGCATTCCT TATTTCCACG 1301 TCGGCAAAAA CGCCGCGCCC GACACGCCGA CCTTAGTCTATGCTTACGGA 1351 GGTTTCGGCA TTCCTGAATT GCCGCATTAT CTGGGCAGCG TCGGCAAATA1401 TTGGCTGGAA GAGGGCAATG CCTTTGTATT GGCAAACATC CGCGGCGGCG 1451GAGAATTCGG CCCGCGCTGG CATCAGGCGG CGCAGGGAAT CAGCAAACAC 1501 AAAAGCGTTGATGATTTGTT GGCAGTCGTG CGTGATTTGT CCGAACGCGG 1551 CATGAGTTCG CCCAAACACATCGGCTTGCA GGGCGGCAGC AACGGCGGCC 1601 TGATTACCGC CGCCGCCTTC GTGCGCGAACCGCAAAGCAT CGGTGCGCTG 1651 GTGTGCGAAG TACCGCTGAC CGATATGATC CGTTATCCGCTGCTGTCCGC 1701 CGGTTCAAGT TGGACGGACG AATACGGCAA TCCGCAGAAA TACGAAGCCT1751 GCAAACGCCG GCTGGGCGAA TTGTCGCCGT ATCACAATCT TTCAGACGGC 1801ATCGATTATC CGCCCGCACT CATTACCACC AGCCTCAGCG ACGACCGCGT 1851 CCATCCCGCCCACGCGCTCA AATTCTACGC CAAACTGCGC GAAACCTCGC 1901 CGCAATCTTG GCTCTACTCGCCTGACGGCG GCGGCCATAC CGGCAACGGC 1951 ACCCAACGCG AATCCGCCGA CAAACTCGCCTGCGTGTTGC TGTTTTTGAA 2001 AGAATTTTTG GGATAAThis corresponds to the amino acid sequence <SEQ ID 160; ORF 041-1.ng>:

g041-1.pep 1 MKSYPDPYRH FENLDSAETQ NFAAEANAET RARFLNNDKA RALSDGILNQ 51MQDTRQIPFC QEHRARMYHF HQNAEYPKGV YRMCTAATYR SGYPEWKILF 101 SVADFDELLGDDVYLGGVSH LVEQPNRALL TLNKSGGDTA YTLEVDLEAG 151 ELVEGGFHFP AGKNHVSWRDENSVWVCPAW DERQLTESGY PREVWLVERG 201 KSFEESLPAY QIDKGAMMVN AWRYLDPQGSPIDLIEASDG FYTKTYLQVS 251 SEGGAKPLNL PNDCDVVGYL AGHLLLTLRK DWHRANQSYPSGALVAVKLN 301 RGELGAAQLL FAPDETQALE SVETTKRFVV ASLLENVQGR LKAWRFADSK351 WQEAELPHLP SGALEMTDQP WGGDVVYLAA SDFTTPLTLF ALDLNVMELT 401VMRLQPQQFV SDGIEVRQFW AVSSDGERIP YFHVGKNAAP DTPTLVYAYG 451 GFGIPELPHYLGSVGKYWLE EGNAFVLANI RGGGEFGPRW HQAAQGISKH 501 KSVDDLLAVV RDLSERGMSSPKHIGLQGGS NGGLITAAAF VREPQSIGAL 551 VCEVPLTDMI RYPLLSAGSS WTDEYGNPQKYEACKRRLGE LSPYHNLSDG 601 IDYPPALITT SLSDDRVHPA HALKFYAKLR ETSPQSWLYSPDGGGHTGNG 651 TQRESADKLA CVLLFLKEFL G*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 161>:

m041-1.seq 1 ATGAAATCCT ACCCCGACCC CTACCGCCAT TTTGAAAACC TCGATTCCGC 51CGAAACGCAA AACTTCGCTG CTGAAGCGAA TGCCGAAACG CGCGCGCGTT 101 TTTTAGAAAACGACAAGGCG CGCGCGCTTT CAGACGGCAT TTTGGCGCAG 151 TTGCAGGACA CGCGGCAGATTCCGTTTTGT CAGGAACACC GCGCGCGGAT 201 GTACCATTTC CATCAGGACG CGGAGTATCCGAAGGGCGTG TACCGCGTGT 251 GTACCGCGGC GACGTATCGT TCCGGCTATC CCGAGTGGAAAATCCTGTTT 301 TCGGTGGCGG ATTTCGACGA ATTGCTTGGC GACGATGTGT ATTTGGGCGG351 CGTGTCGCAC TTGGTGGAAC AGCCCAACCG CGCGTTGTTA ACACTGAGCA 401AATTGGGCAG CGATACGGCG TACACGCTGG AAGTGGATTT GGAAGCAGGG 451 GAGTTGGTCGAAGGCGGTTT TCACTTTCCG GCAGGCAAAA ACCATGTGTC 501 GTGGCGCGAT GAAAACAGCGTGTGGGTGTG TCCGGCTTGG AACGAACGCC 551 AGTTGACCCA ATCGGGCTAT CCGCGCGAAGTATGGCTGGT GGAACGCGGC 601 AAGAGTTTCG AGGAAAGCCT GCCTGTGTAT CAAATCGGCGAAGACGGCAT 651 GATGGTGAAC GCGTGGCGTT ATCTCGATCC GCAGGGTTCG CCGATTGATT701 TGATTGAAGC GTCGGACGGT TTTTACACCA AAACCTATTT GCGGGTCTCA 751GCCGAAGGCG AGGCGAAACC GTTAAACCTG CCCAACGATT GCGACGTGGT 801 CGGCTATCTGGCGGGGCATC TTTTGCTGAC GCTGCGCAAG GACTGGAACC 851 GCGCGAACCA AAGCTATCCGAGCGGCGCGC TGGTGGCGGT GAAGCTGAAT 901 CGGGGCGAAC TCGGGGCGGC GCAGCTTTTGTTTGCGCCCG ATGAAACGCA 951 GGCATTGGAA AGCGTGGAAA CGACCAAGCG TTTTGTGGTGGCGAGCCTGT 1001 TGGAGAACGT ACAAGGCCGT CTGAAAGCAT GGCGGTTTGC CGACGGCAAA1051 TGGCAGGAAG TCGAATTGCC GCGCCTGCCT TCGGGCGCGT TGGAAATGAC 1101CGACCAACCT TGGGGCGGCG ACGTGGTTTA CCTTGCCGCC AGCGATTTCA 1151 CCACGCCGCTGACGCTGTTT GCGCTGGATT TGAACGTGAT GGAACTGACC 1201 GTCATGCGCC GCCAGCCGCAGCAGTTTGAT TCAGACGGCA TTAACGTGCA 1251 GCAGTTTTGG ACGACTTCGG CTGACGGCGAGCGCATTCCT TATTTCCACG 1301 TCGGCAAAAA CGCCGCGCCC GACATGCCGA CGCTGGTCTATGCCTACGGC 1351 GGTTTCGGCA TTCCCGAATT GCCGCATTAT CTGGGCAGCA TTGGCAAATA1401 TTGGCTGGAA GAGGGCAATG CCTTTGTATT GGCGAACATC CGCGGCGGCG 1451GCGAGTTCGG CCCGCGCTGG CATCAGGCGG CGCAGGGAAT CAGCAAACAT 1501 AAAAGCGTTGATGATTTATT GGCAGTCGTG CGCGATTTGT CCGAACGCGG 1551 TATCAGTTCG CCCGAACACATCGGCTTGCA GGGCGGCAGC AACGGCGGAC 1601 TGATTACTGC CGCCGCCTTC GTGCGCGAACCGCAAAGCAT CGGCGCGCTG 1651 GTGTGCGAAG TGCCGCTGAC CGACATGATC CGTTATCCGCTGCTCTCCGC 1701 CGGTTCAAGC TGGACAGACG AATACGGCAA TCCGCAAAAA TACGAAGTCT1751 GCAAACGCCG GTTGGGCGAA TTGTCGCCGT ATCACAATCT TTCAGACGGC 1801ATCGATTATC CGCCCGCGCT CATTACCACC AGCCTGTCCG ACGATCGCGT 1851 CCATCCCGCCCACGCGCTCA AGTTCTACGC CAAACTGCGC GAAACCTCCG 1901 CGCAATCTTG GCTCTACTCGCCTGACGGCG GCGGCCATAC CGGCAACGGC 1951 ACCCAACGCG AATCCGCCGA CGAACTCGCCTGCGTCTTGC TGTTTTTGAA 2001 AGAGTTTTTG GGCTAAThis corresponds to the amino acid sequence <SEQ ID 162; ORF 041-1>:

m041-1.pep 1 MKSYPDPYRH FENLDSAETQ NFAAEANAET RARFLENDKA RALSDGILAQ 51LQDTRQIPFC QEHRARMYHF HQDAEYPKGV YRVCTAATYR SGYPEWKILF 101 SVADFDELLGDDVYLGGVSH LVEQPNRALL TLSKLGSDTA YTLEVDLEAG 151 ELVEGGFHFP AGKNHVSWRDENSVWVCPAW NERQLTQSGY PREVWLVERG 201 KSFEESLPVY QIGEDGMMVN AWRYLDPQGSPIDLIEASDG FYTKTYLRVS 251 AEGEAKPLNL PNDCDVVGYL AGHLLLTLRK DWNRANQSYPSGALVAVKLN 301 RGELGAAQLL FAPDETQALE SVETTKRFVV ASLLENVQGR LKAWRFADGK351 WQEVELPRLP SGALEMTDQP WGGDVVYLAA SDFTTPLTLF ALDLNVMELT 401VMRRQPQQFD SDGINVQQFW TTSADGERIP YFHVGKNAAP DMPTLVYAYG 451 GFGIPELPHYLGSIGKYWLE EGNAFVLANI RGGGEFGPRW HQAAQGISKH 501 KSVDDLLAVV RDLSERGISSPEHIGLQGGS NGGLITAAAF VREPQSIGAL 551 VCEVPLTDMI RYPLLSAGSS WTDEYGNPQKYEVCKRRLGE LSPYHNLSDG 601 IDYPPALITT SLSDDRVHPA HALKFYAKLR ETSAQSWLYSPDGGGHTGNG 651 TQRESADELA CVLLFLKEFL G* m041-1/g041-1 94.6% identity in671 aa overlap        10        20        30        40        50        60 m041-1.pepMKSYPDPYRHFENLDSAETQNFAAEANAETRARFLENDKARALSDGILAQLQDTRQIPFC|||||||||||||||||||||||||||||||||||:|||||||||||| |:||||||||| g041-1MKSYPDPYRHFENLDSAETQNFAAEANAETRARFLNNDKARALSDGILNQMQDTRQIPFC        10        20        30        40        50        60        70        80        90       100       110       120 m041-1.pepQEHRARMYHFHQDAEYPKGVYRVCTAATYRSGYPEWKILFSVADFDELLGDDVYLGGVSH||||||||||||:|||||||||:||||||||||||||||||||||||||||||||||||| g041-1QEHRARMYHFHQNAEYPKGVYRMCTAATYRSGYPEWKILFSVADFDELLGDDVYLGGVSH        70        80        90       100       110       120       130       140       150       160       170       180 m041-1.pepLVEQPNRALLTLSKLGSDTAYTLEVDLEAGELVEGGFHFPAGKNHVSWRDENSVWVCPAW||||||||||||:| |:||||||||||||||||||||||||||||||||||||||||||| g041-1LVEQPNRALLTLNKSGGDTAYTLEVDLEAGELVEGGFHFPAGKNHVSWRDENSVWVCPAW       130       140       150       160       170       180       190       200       210       220       230       240 m041-1.pepNERQLTQSGYPREVWLVERGKSFEESLPVYQIGEDGMMVNAWRYLDPQGSPIDLIEASDG:|||||:|||||||||||||||||||||:||| : :|||||||||||||||||||||||| g041-1DERQLTESGYPREVWLVERGKSFEESLPAYQIDKGAMMVNAWRYLDPQGSPIDLIEASDG       190       200       210       220       230       240       250       260       270       280       290       300 m041-1.pepFYTKTYLRVSAEGEAKPLNLPNDCDVVGYLAGHLLLTLRKDWNRANQSYPSGALVAVKLN|||||||:||:|| ||||||||||||||||||||||||||||:||||||||||||||||| g041-1FYTKTYLQVSSEGGAKPLNLPNDCDVVGYLAGHLLLTLRKDWHRANQSYPSGALVAVKLN       250       260       270       280       290       300       310       320       330       340       350       360 m041-1.pepRGELGAAQLLFAPDETQALESVETTKRFVVASLLENVQGRLKAWRFADGKWQEVELPRLP||||||||||||||||||||||||||||||||||||||||||||||||:||||:|||:|| g041-1RGELGAAQLLFAPDETQALESVETTKRFVVASLLENVQGRLKAWRFADSKWQEAELPHLP       310       320       330       340       350       360       370       380       390       400       410       420 m041-1.pepSGALEMTDQPWGGDVVYLAASDFTTPLTLFALDLNVMELTVMRRQPQQFDSDGINVQQFW||||||||||||||||||||||||||||||||||||||||||| ||||| ||||:|:||| g041-1SGALEMTDQPWGGDVVYLAASDFTTPLTLFALDLNVMELTVMRLQPQQFVSDGIEVRQFW       370       380       390       400       410       420       430       440       450       460       470       480 m041-1.pepTTSADGERIPYFHVGKNAAPDMPTLVYAYGGFGIPELPHYLGSIGKYWLEEGNAFVLANI::|:||||||||||||||||| |||||||||||||||||||||:|||||||||||||||| g041-1AVSSDGERIPYFHVGKNAAPDTPTLVYAYGGFGIPELPHYLGSVGKYWLEEGNAFVLANI       430       440       450       460       470       480       490       500       510       520       530       540 m041-1.pepRGGGEFGPRWHQAAQGISKHKSVDDLLAVVRDLSERGISSPEHIGLQGGSNGGLITAAAF|||||||||||||||||||||||||||||||||||||:|||:|||||||||||||||||| g041-1RGGGEFGPRWHQAAQGISKHKSVDDLLAVVRDLSERGMSSPKHIGLQGGSNGGLITAAAF       490       500       510       520       530       540       550       560       570       580       590       600 m041-1.pepVREPQSIGALVCEVPLTDMIRYPLLSAGSSWTDEYGNPQKYEVCKRRLGELSPYHNLSDG||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||| g041-1VREPQSIGALVCEVPLTDMIRYPLLSAGSSWTDEYGNPQKYEACKRRLGELSPYHNLSDG       550       560       570       580       590       600       610       620       630       640       650       660 m041-1.pepIDYPPALITTSLSDDRVHPAHALKFYAKLRETSAQSWLYSPDGGGHTGNGTQRESADELA||||||||||||||||||||||||||||||||| |||||||||||||||||||||||:|| g041-1IDYPPALITTSLSDDRVHPAHALKFYAKLRETSPQSWLYSPDGGGHTGNGTQRESADKLA       610       620       630       640       650       660        670m041-1.pep CVLLFLKEFLGX |||||||||||| g041-1 CVLLFLKEFLGX        670m041-1/P55577 sp|P55577|Y4NA_RHISN PROBABLE PEPTIDASE Y4NA >gi|2182536(AE000086) Y4nA [Rhizobium sp. NGR234] Length = 726 Score = 370 bits(940), Expect = e−101 Identities = 217/682 (31%), Positives = 331/682(47%), Gaps = 22/682 (3%) Query: 2KSYPDPYRHFENLDSAETQNFAAEANAETRARFLENDKARALSDGILAQLQDTRQIPFCQ 61K   DP  +   +D  +   +    N  T  +  ++ +        L  LQ T +I Sbjct: 42KDASDPRAYLNEIDGDKAMTWVEAHNLSTVDKLSKDPRYSEYQADALTILQATDRIASPS 101 Query:62 EHRARMY-HFHQDAEYPKGVYRVCTAATYRSGYPEWKILFSVADFDELLGDDVYLGGVSH 120  R  M  +F QD  + +G++R  T  +YRSG P+W+ +  V    +  G      G Sbjct: 102FARDGMIDNFWQDGTHVQGLWRRTTWESYRSGNPQWRTILDVDALSKAEGKTWVFEGGDC 161 Query:121 LVEQPNRALLTLSKLGSDTAYTLEVDLEAGELVEGGFHFPAGKNHVSWRDENSVWVCPAW 180L    N  L+ LS  G D     E D+  GE V+ GF  P GK  V+W DEN+++V   W Sbjct: 162LPPTSNLCLIRLSDGGKDADVVREFDIAKGEFVKEGFVLPEGKQSVTWVDENTIYVTREW 221 Query:181 NERQLTQSGYPREVWLVERGKSFEESLPVYQ------IGEDGMM--VNAWRYLDPQGSPI 232   ++T SGY     +V+RG+S ++++ +++        E G++  ++    +D     + Sbjct: 222TPGEVTSSGYAYVTKVVKRGQSLDQAVEIFRGQKKDVSAERGVLRDIDGKYVMDTSYRGL 281 Query:233 DLIEASDGFYTKTYLRVSAEGEAKPLNLPNDCDVVGYLAGHLLLTLRKDWNRANQS-YPS 291D       FY   +     +     L LP      GY  G  +  L+ DW  A  + + + Sbjct: 282DFFNTELAFYPNGH----PDTRKVVLPLPTTAVFSGYYKGQAIYWLKSDWTSAKGTVFHN 337 Query:292 GALVAVKLNRGELGAAQL----LFAPDETQALESVETTKRFVVASLLENVQGRLKAWRFA 347GA++A  L       A++    LF P+E Q++     TK  +V S+L NV   ++++ F Sbjct: 338GAIIAFDLKAALADPARVEPLVLFMPNEHQSVAGTTQTKNRLVLSILSNVTSEVRSFDFG 397 Query:348 DGKWQEVELPRLPSGALEMTDQPWGGDVVYLAASDFTTPLTLFALDLNVMELTVMRRQPQ 407  GW   +L    +  L +T      D +++ +  F  P TLF  D    ++  +   P Sbjct: 398KGGWSSFKLALPENSTLSLTSSDDESDQLFVFSEGFLEPSTLFCADAATGQVEKITSTPA 457 Query:408 QFDSDGINVQQFWTTSADGERIPYFHVGKNAAP---DMPTLVYAYGGFGIPELPHYLGSI 464+FD+ G+  QQFW TS DG ++PYF V +         PT++YAYGGF IP  P Y   + Sbjct: 458RFDAGGLQAQQFWATSKDGTKVPYFLVARKDVKLDGTNPTILYAYGGFQIPMQPSYSAVL 517 Query:465 GKYWLEEGNAFVLANIRGGGEFGPRWHQAAQGISKHKSVDDLLAVVRDLSERGISSPEHI 524 GKWLE+G A+ LANIRGGGEFGP+WH A    ++ +  DD  AV +DL  + ++S  H+ Sbjct: 518GKLWLEKGGAYALANIRGGGEFGPKWHDAGLKTNRQRVYDDFQAVAQDLIAKKVTSTPHL 577 Query:525 GLQGGSNGGLITAAAFVREPQSIGALVCEVPLTDMIRYPLLSAGSSWTDEYGNPQKYEVC 584G+ GGSNGGL+     ++ P    A+V +VPL DM+ +  +SAG+SW  EYG+P    V Sbjct: 578GIMGGSNGGLLMGVQMIQRPDLWNAVVIQVPLLDMVNFTRMSAGASWQAEYGSPDD-PVE 636 Query:585 KRRLGELSPYHNLSDGIDYPPALITTSLSDDRVHPAHALKFYAKLRETSAQSWLYSPDGG 644   L  +SPYHN+  G+ YP     TS  DDRV P HA K  A   +     + Y    G Sbjct: 637GAFLRSISPYHNVKAGVAYPEPFFETSTKDDRVGPVHARKMAALFEDMGLPFYYYENIEG 696 Query:645 GHTGNGTQRESADELACVLLFL 666 GH      +E A   A   +++ Sbjct: 697GHAAAANLQEHARRYALEYIYM 718The following partial DNA sequence was identified in N. meningitidis<SEQ ID 163>:

a041-1.seq 1 ATGAAATCCT ACCCCGACCC CTACCGCCAT TTTGAAAACC TCGATTCCGC 51CGAAACGCAA AACTTCGCTG CTGAAGCGAA TGCCGAAACG CGCGCGCGTT 101 TTTTAAACAACGACAAGGCA CGCGCATTGT CTGACGGCAT TTTGGCGCAG 151 TTGCAGGACA CGCGGCAAATTCCGTTTTGT CAGGAACACC GCGCGCGGAT 201 GTACCATTTC CATCAAGATG CGGAATATCCGAAAGGCGTG TACCGCGTGT 251 GTACCGCGGC GACTTACCGT TCGGGCTATC CTGAGTGGAAAATCCTGTTT 301 TCGGTGGCGG ATTTCGACGA ATTGCTCGGT GACGATGTAT ATCTAGGCGG351 CGTGTCGCAC CTGGTGGAAC AGCCCAACCG CGCGTTGTTA ACACTGAGCA 401AATCGGGCGG CGATACCGCG TACACGCTGG AAGTGGATTT GGAAGCAGGG 451 GAGTTGGTAGAAGGCGGTTT TCACTTTCCG GCAGGCAAAA ACCATGTGTC 501 GTGGCGCGAT GAAAACAGCGTGTGGGTGTG TCCGGCTTGG GACGAACGCC 551 AGTTGACCGA ATCGGGCTAT CCGCGCGAGGTGTGGCTGGT GGAACGCGGC 601 AAGAGTTTCG AGGAAAGCCT GCCGGTGTAC CAAATTGCTGAAGACGGCAT 651 GATGGTGAAC GCGTGGCGTT ACCTCGATCC GCAGGGTTCG CCGATTGATT701 TGATTGAAGC GTCTGACGGT TTTTACACCA AAACCTATTT GCAGGTCTCA 751GCCGAAGGCG AAGCGAAACC GTTAAACCTG CCCAACGATT GCGACGTAGT 801 CGGCTATCTGGCCGGACATC TTTTGCTGAC CTTGCGTAAA GACTGGCACC 851 GCGCGAACCA AAGCTATCCGAGTGGCGCAT TGGTAGCAGT AAAATTAAAC 901 CGCGGCGAAT TGGGCGCGGC GCAGCTTTTGTTTGCGCCCA ATGAAACGCA 951 GGCATTGGAA AGCGTGGAAA CGACCAAGCG TTTTGTCGTGGCGAGCCTGC 1001 TGGAAAACGT ACAGGGTCGT CTGAAAGCGT GGCGTTTTAC TGATGGCAAA1051 TGGCAGGAAA CCGAGTTGCC GCGCCTGCCT TCGGGCGCGT TGGAAATGAC 1101CGACCAACCG TGGGGGGGCG ACGTAGTTTA CCTTGCCGCC AGCGATTTCA 1151 CCACGCCGCTGACGCTGTTT GCATTGGATT TGAACGTGAT GGAACTGACC 1201 GTCATGCGCC GCCAGCCGCAGCAGTTTGAT TCAGACGGCA TTAACGTGCA 1251 GCAGTTTTGG ACGACTTCGG CTGACGGCGAGCGCATTCCT TATTTCCACG 1301 TCGGCAAAAA CGCCGCGCCC GACATGCCGA CGCTGGTCTATGCCTACGGC 1351 GGTTTCGGCA TTCCCGAATT GCCGCATTAT CTGGGCAGCA TTGGCAAATA1401 TTGGCTGGAA GAGGGCAATG CCTTTGTATT GGCGAACATC CGCGGCGGCG 1451GCGAGTTCGG CCCGCGCTGG CATCAGGCGG CGCAGGGAAT CAGCAAACAT 1501 AAAAGCGTTGATGATTTATT GGCAGTCGTG AGCGATTTGT CCGAACGCGG 1551 TATCAGTTCG CCCGAACACATCGGCTTGCA GGGCGGCAGC AACGGCGGAC 1601 TGATTACTGC CGCCGCCTTC GTGCGCGAACCGCAAAGCAT AGGCGCGCTG 1651 GTGTGCGAAG TGCCGCTGAC CGACATGATC CGTTATCCGCTGCTCTCCGC 1701 CGGTTCAAGC TGGACAGACG AATACGGCAA TCCGCAAAAA TACGAAGTCT1751 GCAAACGCCG GTTGGGCGAA TTGTCGCCGT ATCACAATCT TTCAGACGGC 1801ATCGATTATC CGCGCGCGCT CATTACCACC AGCCTGTCCG ACGATCGCGT 1851 CCATCCCGCCCACGCGCTCA AGTTCTACGC CAAACTGCGC GAAACCTCGC 1901 CGCAATCTTG GCTCTACTCGCCTGACGGCG GCGGCCATAC CGGCAACGGC 1951 ACGCAGCGCG AAGCCGCCGA CGAACTCGCCTGCGTGTTGC TGTTTTTGAA 2001 AGAGTTTTTG GGCTAAThis corresponds to the amino acid sequence <SEQ ID 164; ORF 041-1.a>:

a041-1.pep 1 MKSYPDPYRH FENLDSAETQ NFAAEANAET RARFLNNDKA RALSDGILAQ 51LQDTRQIPFC QEHRARMYHF HQDAEYPKGV YRVCTAATYR SGYPEWKILF 101SVADFDELLG DDVYLGGVSH LVEQPNRALL TLSKSGGDTA YTLEVDLEAG 151ELVEGGFHFP AGKNHVSWRD ENSVWVCPAW DERQLTESGY PREVWLVERG 201KSFEESLPVY QIAEDGMMVN AWRYLDPQGS PIDLIEASDG FYTKTYLQVS 251AEGEAKPLNL PNDCDVVGYL AGHLLLTLRK DWHRANQSYP SGALVAVKLN 301RGELGAAQLL FAPNETQALE SVETTKRFVV ASLLENVQGR LKAWRFTDGK 351WQETELPRLP SGALEMTDQP WGGDVVYLAA SDFTTPLTLF ALDLNVMELT 401VMRRQPQQFD SDGINVQQFW TTSADGERIP YFHVGKNAAP DMPTLVYAYG 451GFGIPELPHY LGSIGKYWLE EGNAFVLANI RGGGEFGPRW HQAAQGISKH 501KSVDDLLAVV SDLSERGISS PEHIGLQGGS NGGLITAAAF VREPQSIGAL 551VCEVPLTDMI RYPLLSAGSS WTDEYGNPQK YEVCKRRLGE LSPYHNLSDG 601IDYPPALITT SLSDDRVHPA HALKFYAKLR ETSPQSWLYS PDGGGHTGNG 651TQREAADELA CVLLFLKEFL G* a041-1/m041-1 97.9% identity in 671 aa overlap        10        20        30        40        50        60 a041-1.pepMKSYPDPYRHFENLDSAETQNFAAEANAETRARFLNNDKARALSDGILAQLQDTRQIPFC|||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| m041-1MKSYPDPYRHFENLDSAETQNFAAEANAETRARFLENDKARALSDGILAQLQDTRQIPFC        10        20        30        40        50        60        70        80        90       100       110       120 a041-1.pepQEHRARMYHFHQDAEYPKGVYRVCTAATYRSGYPEWKILFSVADFDELLGDDVYLGGVSH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m041-1QEHRARMYHFHQDAEYPKGVYRVCTAATYRSGYPEWKILFSVADFDELLGDDVYLGGVSH        70        80        90       100       110       120       130       140       150       160       170       180 a041-1.pepLVEQPNRALLTLSKSGGDTAYTLEVDLEAGELVEGGFHFPAGKNHVSWRDENSVWVCPAW|||||||||||||| |:||||||||||||||||||||||||||||||||||||||||||| m041-1LVEQPNRALLTLSKLGSDTAYTLEVDLEAGELVEGGFHFPAGKNHVSWRDENSVWVCPAW       130       140       150       160       170       180       190       200       210       220       230       240 a041-1.pepDERQLTESGYPREVWLVERGKSFEESLPVYQIAEDGMMVNAWRYLDPQGSPIDLIEASDG:|||||:|||||||||||||||||||||||||:||||||||||||||||||||||||||| m041-1NERQLTQSGYPREVWLVERGKSFEESLPVYQIGEDGMMVNAWRYLDPQGSPIDLIEASDG       190       200       210       220       230       240       250       260       270       280       290       300 a041-1.pepFYTKTYLQVSAEGEAKPLNLPNDCDVVGYLAGHLLLTLRKDWHRANQSYPSGALVAVKLN|||||||:||||||||||||||||||||||||||||||||||:||||||||||||||||| m041-1FYTKTYLRVSAEGEAKPLNLPNDCDVVGYLAGHLLLTLRKDWNRANQSYPSGALVAVKLN       250       260       270       280       290       300       310       320       330       340       350       360 a041-1.pepRGELGAAQLLFAPNETQALESVETTKRFVVASLLENVQGRLKAWRFTDGKWQETELPRLP|||||||||||||:||||||||||||||||||||||||||||||||:||||||:|||||| m041-1RGELGAAQLLFAPDETQALESVETTKRFVVASLLENVQGRLKAWRFADGKWQEVELPRLP       310       320       330       340       350       360       370       380       390       400       410       420 a041-1.pepSGALEMTDQPWGGDVVYLAASDFTTPLTLFALDLNVMELTVMRRQPQQFDSDGINVQQFW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m041-1SGALEMTDQPWGGDVVYLAASDFTTPLTLFALDLNVMELTVMRRQPQQFDSDGINVQQFW       370       380       390       400       410       420       430       440       450       460       470       480 a041-1.pepTTSADGERIPYFHVGKNAAPDMPTLVYAYGGFGIPELPHYLGSIGKYWLEEGNAFVLANI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m041-1TTSADGERIPYFHVGKNAAPDMPTLVYAYGGFGIPELPHYLGSIGKYWLEEGNAFVLANI       430       440       450       460       470       480       490       500       510       520       530       540 a041-1.pepRGGGEFGPRWHQAAQGISKHKSVDDLLAVVSDLSERGISSPEHIGLQGGSNGGLITAAAF|||||||||||||||||||||||||||||| ||||||||||||||||||||||||||||| m041-1RGGGEFGPRWHQAAQGISKHKSVDDLLAVVRDLSERGISSPEHIGLQGGSNGGLITAAAF       490       500       510       520       530       540       550       560       570       580       590       600 a041-1.pepVREPQSIGALVCEVPLTDMIRYPLLSAGSSWTDEYGNPQKYEVCKRRLGELSPYHNLSDG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m041-1VREPQSIGALVCEVPLTDMIRYPLLSAGSSWTDEYGNPQKYEVCKRRLGELSPYHNLSDG       550       560       570       580       590       600       610       620       630       640       650       660 a041-1.pepIDYPPALITTSLSDDRVHPAHALKFYAKLRETSPQSWLYSPDGGGHTGNGTQREAADELA||||||||||||||||||||||||||||||||| ||||||||||||||||||||:||||| m041-1IDYPPALITTSLSDDRVHPAHALKFYAKLRETSAQSWLYSPDGGGHTGNGTQRESADELA       610       620       630       640       650       660        670a041-1.pep CVLLFLKEFLGX |||||||||||| m041-1 CVLLFLKEFLGX        670The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 165>:

g042.seq 1 ATGACGATGA TTTGCTTGCG CTTCCAagcG TTCGTGCCGC ATACCAGCGC 51GTTATCCAAC ACTTCCACGG CAGCCGGCCC TTCCTGCCCG ATGGCGGCGG 101TGCGGTCGAT GATGAAAATC CAGCCGGGGT TTTTCTCTTT GATGTATTCG 151AAGGAAACGG GCTGCCCGTG CCCTTCGTTG CGTAAAGATT CGTCCACGGG 201CGGCAGGCCG ATGTCGCCGT GTATCCAACT TGCCAACCGC GATTGCGTGC 251CGAAGGCGGA CACCTTGTTG CCTGTAACCG ACAGCACCAG CCCGCGTCCT 301TTGCCTTTGG cggCTTCGCG CTTTTGGGCG AACAGCGCGT CAATCTGCGC 351ATTCAATTCC GCCACGCGCG CTTCCTTACC GAAAATCCGC GACAGGGTCT 401CCATCTGCTT CTCGCCGCTG GTGCGGATAT TGCCGTTGTC CACCGTCAAA 451TCTATGgtgG TCGCGTTTTT CGCCAACTGT TCATACGCTT CCGCACCCGG 501CCCGCCGGTA ATGACAAACT GCGGATTGTG GCGGTGCAGG GATTCGCAAT 551CGGGCTCAAA CAGCGTCCCC ACCGTTGCCG CCTTGTCAAA TGCAGGCTGC 601 AAATAGThis corresponds to the amino acid sequence <SEQ ID 166; ORF 042.ng>:

g042.pep 1 MTMICLRFQA FVPHTSALSN TSTAAGPSCP MAAVRSMMKI QPGFFSLMYS 51KETGCPCPSL RKDSSTGGRP MSPCIQLANR DCVPKADTLL PVTDSTSPRP 101LPLAASRFWA NSASICAFNS ATRASLPKIR DRVSICFSPL VRILPLSTVK 151SMVVAFFANC SYASAPGPPV MTNCGLWRCR DSQSGSNSVP TVAALSNAGC 201 K*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 167>:

m042.seq 1 ATGACGATGA TTTGCTTGCG CTTCCAAGCG TTCGTGCCGC GTACCAGCGC 51GTTATCCAmT ACTTCGACAG CCGcCGGCCy TTCyTGCCCG ATGGCGGCGG 101TACGGTCGAT GATGAAAATC CAATCGGGGT TTTTCTCTTT GATGTATTCG 151AAGGAAACAG GCTGCCCGTG CCCCTCGTTG CGTAAAGATT CGTCTACAGG 201CGGTAGGCCG ATGTCGCCGT GTATCCAACT TGCCAACCGC GACTGCGTGC 251CGAAGGCGGA CACCTTGTTG CCCGTAACCG ACAGCACCAG CCCGCGTCCT 301TTGCCTTTGG CGGCTTCGCG CGTTTGGGCG AACAGCGCGT CAATCTGCGC 351CTTCAATTCC GCCGCGCGCG CTTCCTTGCC GAAAATCCGC GCCAAGGTCT 401CCATCTGCTT TTCGCCGCTG GTGCGGATAT TGCCGTTGTC CACCGTCAGA 451TCTATGGTGG TCGCGTTTTT CGCTAACTGT TCATACGCTT CCGCGCCCGG 501CCCGCCGGTA ATGACAAGCT GAGGATTGTA GCGGTGCAGG GCTTCGTAAT 551CGGGCTCGAA CAGCGTCCCC ACCGTTGCCG CCTTGTCAAA TGCAGGCTGC 601 AAATAAThis corresponds to the amino acid sequence <SEQ ID 168; ORF 042>:

m042.pep 1 MTMICLRFQA FVPRTSALSX TSTAAGXSCP MAAVRSMMKI QSGFFSLMYS 51KETGCPCPSL RKDSSTGGRP MSPCIQLANR DCVPKADTLL PVTDSTSPRP 101LPLAASRVWA NSASICAFNS AARASLPKIR AKVSICFSPL VRILPLSTVR 151SMVVAFFANC SYASAPGPPV MTSXGLXRCR ASXSGSNSVP TVAALSNAGC 201 K*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 169>:

a042.seq 1 ATGACGATGA TTTGCTTGCG CTTCCAAGCG TTCGTGCCGC GTACCAGCGC 51GTTATCCAAT ACTTCGACAG CCGCCGGCCC TTCCTGCCCG ATGGCGGCGG 101TACGGTCGAT GATGAAAATC CAATCGGGGT TTTTCTCTTT GATGTATTCG 151AAGGAAACAG GCTGCCCGTG CCCCTCGTTG CGTAAAGATT CGTCTACAGG 201CGGTAGGCCG ATGTCGCCGT GTATCCAACT TGCCAACCGC GACTGCGTGC 251CGAAGGCGGA CACCTTGTTG CCCGTAACCG ACAGCACCAG CCCGCGTCCT 301TTGCCTTTGG CGGCTTCGCG CGTTTGGGCG AACAGCGCGT CAATCTGCGC 351CTTCAATTCC GCCGCGCGCG CTTCCTTGCC GAAAATCCGC GCCAAGGTCT 401CCATCTGCTT TTCGCCGCTG GTGCGGATAT TGCCGTTGTC CACCGTCAGA 451TCTATGGTGG TCGCGTTTTT CGCCAACTGT TCATACGCTT CCGCGCCCGG 501CCCGCCGGTA ATGACAAGCT GAGGATTGTA GCGGTGCAGG GCTTCGTAAT 551CGGGCTCGAA CAGCGTCCCC ACCGTTGCCG CCTTGTCAAA TGCAGGCTGC 601 AAATAAThis corresponds to the amino acid sequence <SEQ ID 170; ORF 042.a>:

a042.pep 1 MTMICLRFQA FVPRTSALSN TSTAAGPSCP MAAVRSMMKI QSGFFSLMYS 51KETGCPCPSL RKDSSTGGRP MSPCIQLANR DCVPKADTLL PVTDSTSPRP 101LPLAASRVWA NSASICAFNS AARASLPKIR AKVSICFSPL VRILPLSTVR 151SMVVAFFANC SYASAPGPPV MTS*GL*RCR AS*SGSNSVP TVAALSNAGC 201 K* m042/a04299.0% identity over a 201 aa overlap        10        20        30        40        50        60 m042.pepMTMICLRFQAFVPRTSALSXTSTAAGXSCPMAAVRSMMKIQSGFFSLMYSKETGCPCPSL||||||||||||||||||| |||||| ||||||||||||||||||||||||||||||||| a042MTMICLRFQAFVPRTSALSNTSTAAGPSCPMAAVRSMMKIQSGFFSLMYSKETGCPCPSL        10        20        30        40        50        60        70        80        90       100       110       120 m042.pepRKDSSTGGRPMSPCIQLANRDCVPKADTLLPVTDSTSPRPLPLAASRVWANSASICAFNS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a042RKDSSTGGRPMSPCIQLANRDCVPKADTLLPVTDSTSPRPLPLAASRVWANSASICAFNS        70        80        90       100       110       120       130       140       150       160       170       180 m042.pepAARASLPKIRAKVSICFSPLVRILPLSTVRSMVVAFFANCSYASAPGPPVMTSXGLXRCR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a042AARASLPKIRAKVSICFSPLVRILPLSTVRSMVVAFFANCSYASAPGPPVMTSXGLXRCR       130       140       150       160       170       180       190       200 m042.pep ASXSGSNSVPTVAALSNAGCKX|||||||||||||||||||||| a042 ASXSGSNSVPTVAALSNAGCKX        190       200Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 042 shows 93.0% identity over a 201 aa overlap with a predicted ORF(ORF 042.ng) from N. gonorrhoeae:

m042/g042         10        20        30        40        50        60m042.pep MTMICLRFQAFVPRTSALSXTSTAAGXSCPMAAVRSMMKIQSGFFSLMYSKETGCPCPSL|||||||||||||:||||| |||||| |||||||||||||| |||||||||||||||||| g042MTMICLRFQAFVPHTSALSNTSTAAGPSCPMAAVRSMMKIQPGFFSLMYSKETGCPCPSL        10        20        30        40        50        60        70        80        90       100       110       120 m042.pepRKDSSTGGRPMSPCIQLANRDCVPKADTLLPVTDSTSPRPLPLAASRVWANSASICAFNS||||||||||||||||||||||||||||||||||||||||||||||| |||||||||||| g042RKDSSTGGRPMSPCIQLANRDCVPKADTLLPVTDSTSPRPLPLAASRFWANSASICAFNS        70        80        90       100       110       120       130       140       150       160       170       180 m042.pepAARASLPKIRAKVSICFSPLVRILPLSTVRSMVVAFFANCSYASAPGPPVMTSXGLXRCR |:||||||||:|||||||||||||||||:||||||||||||||||||||||: || ||| g042ATRASLPKIRDRVSICFSPLVRILPLSTVKSMVVAFFANCSYASAPGPPVMTNCGLWRCR       130       140       150       160       170       180       190       200 m042.pep ASXSGSNSVPTVAALSNAGCKX  |||||||||||||||||||| g042 DSQSGSNSVPTVAALSNAGCKX        190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 171>:

m042-1.seq 1 ATGACGATGA TTTGCTTGCG CTTCCAAGCG TTCGTGCCGC GTACCAGCGC 51GTTATCCAAT ACTTCGACAG CCGCCGGCCC TTCCTGCCCG ATGGCGGCGG 101TACGGTCGAT GATGAAAATC CAATCGGGGT TTTTCTCTTT GATGTATTCG 151AAGGAAACAG GCTGCCCGTG CCCCTCGTTG CGTAAAGATT CGTCTACAGG 201CGGTAGGCCG ATGTCGCCGT GTATCCAACT TGCCAACCGC GACTGCGTGC 251CGAAGGCGGA CACCTTGTTG CCCGTAACCG ACAGCACCAG CCCGCGTCCT 301TTGCCTTTGG CGGCTTCGCG CGTTTGGGCG AACAGCGCGT CAATCTGCGC 351CTTCAATTCC GCCGCGCGCG CTTCCTTGCC GAAAATCCGC GCCAAGGTCT 401CCATCTGCTT TTCGCCGCTG GTGCGGATAT TGCCGTTGTC CACCGTCAGA 451TCTATGGTGG TCGCGTTTTT CGCTAACTGT TCATACGCTT CCGCGCCCGG 501 CCCGCCGGTA AThis corresponds to the amino acid sequence <SEQ ID 172; ORF 42-1>:

m042-1.pep 1 MTMICLRFQA FVPRTSALSN TSTAAGPSCP MAAVRSMMKI QSGFFSLMYS 51KETGCPCPSL RKDSSTGGRP MSPCIQLANR DCVPKADTLL PVTDSTSPRP 101LPLAASRVWA NSASICAFNS AARASLPKIR AKVSICFSPL VRILPLSTVR 151SMVVAFFANC SYASAPGPPV MTS* m042-1/g042 95.4% identity in 173 aa overlap        10        20        30        40        50        60 m042-1.pepMTMICLRFQAFVPRTSALSNTSTAAGPSCPMAAVRSMMKIQSGFFSLMYSKETGCPCPSL|||||||||||||:||||||||||||||||||||||||||| |||||||||||||||||| g042MTMICLRFQAFVPHTSALSNTSTAAGPSCPMAAVRSMMKIQPGFFSLMYSKETGCPCPSL        10        20        30        40        50        60        70        80        90       100       110       120 m042-1.pepRKDSSTGGRPMSPCIQLANRDCVPKADTLLPVTDSTSPRPLPLAASRVWANSASICAFNS||||||||||||||||||||||||||||||||||||||||||||||| |||||||||||| g042RKDSSTGGRPMSPCIQLANRDCVPKADTLLPVTDSTSPRPLPLAASRFWANSASICAFNS        70        80        90       100       110       120       130       140       150       160       170 m042-1.pepAARASLPKIRAKVSICFSPLVRILPLSTVRSMVVAFFANCSYASAPGPPVMTSX |:||||||||:|||||||||||||||||:||||||||||||||||||||||: g042ATRASLPKIRDRVSICFSPLVRILPLSTVKSMVVAFFANCSYASAPGPPVMTNCGLWRCR       130       140       150       160       170       180 g042DSQSGSNSVPTVAALSNAGCKX        190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 173>:

a042-1.seq 1 ATGACGATGA TTTGCTTGCG CTTCCAAGCG TTCGTGCCGC GTACCAGCGC 51GTTATCCAAT ACTTCGACAG CCGCCGGCCC TTCCTGCCCG ATGGCGGCGG 101TACGGTCGAT GATGAAAATC CAATCGGGGT TTTTCTCTTT GATGTATTCG 151AAGGAAACAG GCTGCCCGTG CCCCTCGTTG CGTAAAGATT CGTCTACAGG 201CGGTAGGCCG ATGTCGCCGT GTATCCAACT TGCCAACCGC GACTGCGTGC 251CGAAGGCGGA CACCTTGTTG CCCGTAACCG ACAGCACCAG CCCGCGTCCT 301TTGCCTTTGG CGGCTTCGCG CGTTTGGGCG AACAGCGCGT CAATCTGCGC 351CTTCAATTCC GCCGCGCGCG CTTCCTTGCC GAAAATCCGC GCCAAGGTCT 401CCATCTGCTT TTCGCCGCTG GTGCGGATAT TGCCGTTGTC CACCGTCAGA 451TCTATGGTGG TCGCGTTTTT CGCCAACTGT TCATACGCTT CCGCGCCCGG 501 CCCGCCGGTA AThis corresponds to the amino acid sequence <SEQ ID 174; ORF 042-1.a>:

a042-1.pep 1 MTMICLRFQA FVPRTSALSN TSTAAGPSCP MAAVRSMMKI QSGFFSLMYS 51KETGCPCPSL RKDSSTGGRP MSPCIQLANR DCVPKADTLL PVTDSTSPRP 101LPLAASRVWA NSASICAFNS AARASLPKIR AKVSICFSPL VRILPLSTVR 151SMVVAFFANC SYASAPGPPV MTS* m042-1/a042-1100.0% identity in 173 aa overlap        10        20        30        40        50        60 m042-1.pepMTMICLRFQAFVPRTSALSNTSTAAGPSCPMAAVRSMMKIQSGFFSLMYSKETGCPCPSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a042-1MTMICLRFQAFVPRTSALSNTSTAAGPSCPMAAVRSMMKIQSGFFSLMYSKETGCPCPSL        10        20        30        40        50        60        70        80        90       100       110       120 m042-1.pepRKDSSTGGRPMSPCIQLANRDCVPKADTLLPVTDSTSPRPLPLAASRVWANSASICAFNS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a042-1RKDSSTGGRPMSPCIQLANRDCVPKADTLLPVTDSTSPRPLPLAASRVWANSASICAFNS        70        80        90       100       110       120       130       140       150       160       170 m042-1.pepAARASLPKIRAKVSICFSPLVRILPLSTVRSMVVAFFANCSYASAPGPPVMTSX|||||||||||||||||||||||||||||||||||||||||||||||||||||| a042-1AARASLPKIRAKVSICFSPLVRILPLSTVRSMVVAFFANCSYASAPGPPVMTSX       130       140       150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 175>:

g043.seq 1 ATGGTTGTTT CAAATCAAAA TATCTATGCC GTCGGCCCAT CAGCACTTTT 51TCACATCCGA AGGCAAAAAT CCGTAATGCC GCCTGAACGC TTCgttgaAC 101CGTCCCGCGT ggcggtagcc gcAAAAGTGC ATcGCGGCTT GGATGGTGCT 151GCCCGATTCG ATGAGGGcga gcGCGTGTTC CAGCCGCAGG CGGCGCAGGC 201GTCCGGCGAC GGTTTCGCCG GTTTGCGCTT TGAAATAGCG TTTCAGGTAG 251CATTCGTTCA GCCCGACGCG GCGGGCGATT TCGGCGATGG TCAGCGGGCG 301GGCGAATTCG CTGTTCAAAA TATCGGCGGC TTCGTCTATG CGCCGGCGGC 351GGTAGCCGTT GTCGTGGCGG CGGAAGGTGA AGCGTAAThis corresponds to the amino acid sequence <SEQ ID 176; ORF 043.ng>:

g043.pep 1 MVVSNQNIYA VGPSALFHIR RQKSVMPPER FVEPSRVAVA AKVHRGLDGA 51ARFDEGERVF QPQAAQASGD GFAGLRFEIA FQVAFVQPDA AGDFGDGQRA 101GEFAVQNIGG FVYAPAAVAV VVAAEGEA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 177>:

m043.seq 1 ATGGTTGTTT CAAATCAAAA TATCTATGCC GCCGGCCCCT CAGCACTTCT 51TCACATCCGA AGGCAAAAAT CCGTAATGCC GTCTGAACGC TTCGTTGAAC 101CGTCCCGCGT GGCGGTAGCC GCAAAAGTGC ATGGCGGCTT GGACGGTGCT 151GCCGGATTCG ATGAGGGCGA GCGCGTGTTC CAGCCGCAGG CGGCGCAgGC 201ATCCGGCGAC GGTTTCGCCG GTTTGCGCTT TGAAATAGCG TTTCAGGTAG 251CATTCGTTCA GTCCGACGCG GCGGGCGATT TCGGCGATGG TCAGCGGACG 301GGCGAATTCG TGTTGCAGGA TGTCGGCGGC TTCGTCTATG CGCCGACGGC 351GGTAACCGTT GTCGTGGCGG CGGAAGGTGA AGCGCAATAAThis corresponds to the amino acid sequence <SEQ ID 178; ORF 043>:

m043.pep 1 MVVSNQNIYA AGPSALLHIR RQKSVMPSER FVEPSRVAVA AKVHGGLDGA 51AGFDEGERVF QPQAAQASGD GFAGLRFEIA FQVAFVQSDA AGDFGDGQRT 101 GEFVLQDVGGFVYAPTAVTV VVAAEGEAQ*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 043 shows 89.8% identity over a 128 aa overlap with a predicted ORF(ORF043.a) from N. gonorrhoeae:

m043/g043         10        20        30        40        50        60m043.pep MVVSNQNIYAAGPSALLHIRRQKSVMPSERFVEPSRVAVAAKVHGGLDGAAGFDEGERVF||||||||||:|||||:|||||||||| |||||||||||||||| |||||| |||||||| g043MVVSNQNIYAVGPSALFHIRRQKSVMPPERFVEPSRVAVAAKVHRGLDGAARFDEGERVF        10        20        30        40        50        60        70        80        90       100       110       120 m043.pepQPQAAQASGDGFAGLRFEIAFQVAFVQSDAAGDFGDGQRTGEFVLQDVGGFVYAPTAVTV||||||||||||||||||||||||||| |||||||||||:|||::|::|||||||:||:| g043QPQAAQASGDGFAGLRFEIAFQVAFVQPDAAGDFGDGQRAGEFAVQNIGGFVYAPAAVAV        70        80        90       100       110       120        130m043.pep VVAAEGEAQX |||||||| g043 VVAAEGEAXX        130The following partial DNA sequence was identified in N. meningitidis<SEQ ID 179>:

a043.seq 1 ATGGTTGTTT CAAATCAAAA TATCTATGCC GCCGGCCCCT CAGCACTTCT 51TCACATCCGA AGGCAAAAAT CCGTAATGCC GTCTGAACGC TTCGTTGAAC 101 CGTCCCGCGTGGCGGTAGCC GCAAAAGTGC ATGGCGGCTT GGACGGTGCT 151 GCCGGATTCG ATGAGGGCGAGCGCGTGTTC CAGCCGCAGG CGGCGCAGGC 201 ATCCGGCGAC GGTTTCGCCG GTTTGCGCTTTGAAATAGCG TTTCAGGTAG 251 CATTCGTTCA GTCCGACGCG GCGGGCGATT TCGGCGATGGTCAGCGGACG 301 GGCGAATTCG TGTTGCAGGA TGTCGGCGGC TTCGTCTATG CGCCGACGGC351 GGTAACCGTT GTCGTGGCGG CGGAAGGTGA AGCGCAATAAThis corresponds to the amino acid sequence <SEQ ID 180; ORF 043.a>:

a043.pep 1 MVVSNQNIYA AGPSALLHIR RQKSVMPSER FVEPSRVAVA AKVHGGLDGA 51AGFDEGERVF QPQAAQASGD GFAGLRFEIA FQVAFVQSDA AGDFGDGQRT 101GEFVLQDVGG FVYAPTAVTV VVAAEGEAQ* m043/a043 100.0% identity in 129 aaoverlap         10        20        30        40        50        60m043.pep MVVSNQNIYAAGPSALLHIRRQKSVMPSERFVEPSRVAVAAKVHGGLDGAAGFDEGERVF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a043MVVSNQNIYAAGPSALLHIRRQKSVMPSERFVEPSRVAVAAKVHGGLDGAAGFDEGERVF        10        20        30        40        50        60        70        80        90       100       110       120 m043.pepQPQAAQASGDGFAGLRFEIAFQVAFVQSDAAGDFGDGQRTGEFVLQDVGGFVYAPTAVTV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a043QPQAAQASGDGFAGLRFEIAFQVAFVQSDAAGDFGDGQRTGEFVLQDVGGFVYAPTAVTV        70        80        90       100       110       120        130m043.pep VVAAEGEAQX |||||||||| a043 VVAAEGEAQX        130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 181>:

g044.seq 1 ATGCTGCCCG ACCAGAGCGT CGAGTTCTTG CCACAAGTCG TCGTTTTTGA 51CGGGCTGTTT GGCGGCGGTT TTCCAGCCGT TGCGCTTCCA ACCGTGTATC 101 CAGTTTTCCATGCCGTTTTT GACGTATTGC GAGTCGGTGC AGATGATGAC 151 GGTGCAGCGG CGTTTGAGCGATTTCAGCCC TTCGATAACG GCGGTCAGCT 201 CCATGCGGTT GTTGGTGGTT TGCGCTTCGCCGCCGAAAAG TTCTTTTTCG 251 CGGCTGCCGT AGCGCATTAAThis corresponds to the amino acid sequence <SEQ ID 182; ORF 044.ng>:

g044.pep 1 MLPDQSVEFL PQVVVFDGLF GGGFPAVALP TVYPVFHAVF DVLRVGADDD 51GAAAFERFQP FDNGGQLHAV VGGLRFAAEK FFFAAAVAH*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 183>:

m044.seq 1 ATGCCGTCCG ACTAGAGCGT CGAGTTCTTT CCAGAAGTCG TCGTTTTTGA 51CGGGCTGTTT GGAGGCGGTT TTCCAGCCGT TGCGCTTCCA ACCGTGTATC 101 CAGTTTTCCATGCCATTTTT GACGTATTGC GAGTCGGTGC AGATGATGAC 151 GGTGCAGCGG CGTTTGAGCGATTTCAGTCC TTCGATGACG GCAGTCAGTT 201 CCATGCGGTT GTTGGTGGTT TGCGCTTCGCCGCCGAAAAG TTCTTTTTCG 251 TGGCTACCGT AGCGCAyTAaThis corresponds to the amino acid sequence <SEQ ID 184; ORF 044>:

m044.pep 1 MPSDXSVEFF PEVVVFDGLF GGGFPAVALP TVYPVFHAIF DVLRVGADDD 51GAAAFERFQS FDDGSQFHAV VGGLRFAAEK FFFVATVAH*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 185>:

a044.seq 1 GTGCCGTCCG ACCAGCGCGT CGAGTTCTTT CCACAAGTCG TCGTTTTTGA 51CGGGCTGTTT GGCGGCGGTT TTCCAGCCGT TGCGCTTCCA ACCGTGTATC 101 CAGTTTTCCATGCCGTTTTT GACGTATTGC GAGTCGGTGC AGATGATGAC 151 GGTGCAGCGG CGTTTGAGCGATTTCAGTCC TTCGATGACG GCGGTCAGTT 201 CCATACGGTT GTTGGTGGTT TGCGCTTCGCCGCCGAAAAG TTCTTTTTCG 251 TGGCTGCCGT AGCGCATTAAThis corresponds to the amino acid sequence <SEQ ID 186; ORF 044.a>:

a044.pep 1 VPSDQRVEFF PQVVVFDGLF GGGFPAVALP TVYPVFHAVF DVLRVGADDD 51GAAAFERFQS FDDGGQFHTV VGGLRFAAEK FFFVAAVAH* m044/a044 91.0% identityover a 89 aa overlap        10        20        30        40        50        60 m044.pepMPSDXSVEFFPEVVVFDGLFGGGFPAVALPTVYPVFHAIFDVLRVGADDDGAAAFERFQS:|||  |||||:||||||||||||||||||||||||||:||||||||||||||||||||| a044VPSDQRVEFFPQVVVFDGLFGGGFPAVALPTVYPVFHAVFDVLRVGADDDGAAAFERFQS        10        20        30        40        50        60        70        80        90 m044.pep FDDGSQFHAVVGGLRFAAEKFFFVATVAHX||||:|||:||||||||||||||||:|||| a044 FDDGGQFHTVVGGLRFAAEKFFFVAAVAHX        70        80        90Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 044 shows 86.5% identity over a 89 aa overlap with a predicted ORF(ORF 044.ng) from N. gonorrhoeae:

m044/g044         10        20        30        40        50        60m044.pep MPSDXSVEFFPEVVVFDGLFGGGFPAVALPTVYPVFHAIFDVLRVGADDDGAAAFERFQS|  | ||||:|:||||||||||||||||||||||||||:|||||||||||||||||||| g044MLPDQSVEFLPQVVVFDGLFGGGFPAVALPTVYPVFHAVFDVLRVGADDDGAAAFERFQP        10        20        30        40        50        60        70        80        90 m044.pep FDDGSQFHAVVGGLRFAAEKFFFVATVAHX||:|:|:||||||||||||||||:|:|||| g044 FDNGGQLHAVVGGLRFAAEKFFFAAAVAHX        70        80        90The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 187>:

g046.seq 1 ATGTCGGCAA TGCTGCGTCC GACAAGCAGC CCGCCGCgcc gCGCCTGTAT 51GATGACCATC CGCACGCGGT CGTCTGCAAA ACGTAAAACC TGCAATGCGC 101 CCGGGCAGTCTATCAGGCCG GCAAGCTGTT CGGTAACGAG CTGTTCGGGG 151 CTGATGGTTT CGGTTATGCCgaATATGGAA AGGCTGCCGt TTTcGTTGTT 201 TTCGAGCTTG GGGCTGAGGT ATTCGAGGTATtcgctGGAA CGGACGCGCG 251 CGATGCGGCC GGGGATGTTG AACAGGTCGG CGGCAACTTTGCAGGCGACG 301 ATGTTGGTTT CGTCGCTGCG GGagaGCGCG AGcagcaagt cggcatcttC351 CgcgccggcG Cgttataatg tgAAGGGGGA TGCGccgttg ccgaAAACGG 401TTTGGacatc gaggcggctg CCTGTTTCCT GCAATGCTTT TTCGTCGATG 451 TCGATAAcggTTACGTCGTT GTTGGTGATG GCGGCAAGGT TTTGCGCGAC 501 GGTAGAACCT ACCTGCCCGTTGCCTAAAAT GAGGATTTTC ACGGTATGGG 551 TCGCCGGGTG AThis corresponds to the amino acid sequence <SEQ ID 188; ORF 046.ng>:

g046.pep 1 MSAMLRPTSS PPRRACMMTI RTRSSAKRKT CNAPGQSIRP ASCSVTSCSG 51LMVSVMPNME RLPFSLFSSL GLRYSRYSLE RTRAMRPGML NRSAATLQAT 101 MLVSSLRESASSKSASSAPA RYNVKGDAPL PKTVWTSRRL PVSCNAFSSM 151 SITVTSLLVM AARFCATVEPTCPLPKMRIF TVWVAG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 189>:

m046.seq 1 ATGTCGGCAA TGCTGCGTCC GACAAGCAsT CCGC.r.sGC gCGcCTGTAT 51GATGACCATC CGCACGCGGT CGTCTGCAAA ACGTAAAACC TGCAATGCGC 101 CCGGGCAGTCTATCAGGCCG GCAAGCTGTT CGGTAACGAG CTGTTCGGGG 151 CTGATGGTTT CGGTTATGCCGAATATGGAA AGGCTGCCGT TTTCGTTGTT 201 TTCGAGCTTG GGGCTGAGGT ATTCGAGGTATTCGCTGGAA CGGACGCGCG 251 CGATGCGGCC GGGGATGTTG AACAGGTCGG CGGCAACTTTGCAGGCGACG 301 ATGTTGGTTT CGTCGCTGCG GGAGAGCGCG AGCAGCAAGT CGGCATCTTC351 CGCGCCGGCG CGTTCTAATG TGAAGGGGGA TGCGCCGTTG CCGAAAACGG 401TTTGGACATC GAGGCGGCTG CCTGTTTCCT GCAATGCTTT TTCGTCGATG 451 TCGATAACGGTTACGTCGTT GTTGGGTATG GCGGCAAGGT TTTGTGCGAC 501 GGTAGAACCT ACCTGTCCGTTGCCTAAAAT GAGGATTTTC ACGGTGTGGG 551 TCGCCGAGTG AThis corresponds to the amino acid sequence <SEQ ID 190; ORF 046>:

m046.pep 1 MSAMLRPTSX PXXRACMMTI RTRSSAKRKT CNAPGQSIRP ASCSVTSCSG 51LMVSVMPNME RLPFSLFSSL GLRYSRYSLE RTRAMRPGML NRSAATLQAT 101 MLVSSLRESASSKSASSAPA RSNVKGDAPL PKTVWTSRRL PVSCNAFSSM 151 SITVTSLLGM AARFCATVEPTCPLPKMRIF TVWVAE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 191>:

a046.seq 1 ATGTCGGCAA TGCTGCGTCC GACAAGCAGT CCGCCGCGCC GCGCCTGTAT 51GATGACCATC CGCACGCGGT CGTCTGCAAA ACGTAAAACC TGCAATGCGC 101 CCGGGCAGTCTATCAGGCCG GCAAGCTGTT CGGTAACGAG CTGTTCGGGG 151 CTGATGGTTT CGGTTATGCCGAATATGGAA AGGCTGCCGT TTTCGTTGTT 201 TTCGAGCTTG GGGCTGAGGT ATTCGAGGTATTCGCTGGAA CGGACGCGCG 251 CGATGCGGCC GGGGATGTTG AACAGGTCGG CGGCAACTTTGCAGGCGACG 301 ATGTTGGTTT CGTCGCTGCG GGAGAGCGCG AGCAGCAAGT CGGCATCTTC351 CGCGCCGGCG CGTTCTAATG TGAAGGGGGA TGCGCCGTTG CCGAAAACGG 401TTTGGACATC GAGGCGGCTG CCTGTTTCCT GCAATGCTTT TTCGTCGATG 451 TCGATAACGGTTACGTCGTT GTTGGGTATG GCGGCAAGGT TTTGTGCGAC 501 GGTAGAACCT ACCTGTCCGTTGCCTAAAAT GAGGATTTTC ACGGTGTGGG 551 TCGCCGAGTG AThis corresponds to the amino acid sequence <SEQ ID 192; ORF 046.a>:

a046.pep 1 MSAMLRPTSS PPRRACMMTI RTRSSAKRKT CNAPGQSIRP ASCSVTSCSG 51LMVSVMPNME RLPFSLFSSL GLRYSRYSLE RTRAMRPGML NRSAATLQAT 101 MLVSSLRESASSKSASSAPA RSNVKGDAPL PKTVWTSRRL PVSCNAFSSM 151 SITVTSLLGM AARFCATVEPTCPLPKMRIF TVWVAE* m046/a046 98.4% identity over a 186 aa overlap        10        20        30        40        50        60 m046.pepMSAMLRPTSXPXXRACMMTIRTRSSAKRKTCNAPGQSIRPASCSVTSCSGLMVSVMPNME||||||||| |  ||||||||||||||||||||||||||||||||||||||||||||||| a046MSAMLRPTSSPPRRACMMTIRTRSSAKRKTCNAPGQSIRPASCSVTSCSGLMVSVMPNME        10        20        30        40        50        60        70        80        90       100       110       120 m046.pepRLPFSLFSSLGLRYSRYSLERTRAMRPGMLNRSAATLQATMLVSSLRESASSKSASSAPA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a046RLPFSLFSSLGLRYSRYSLERTRAMRPGMLNRSAATLQATMLVSSLRESASSKSASSAPA        70        80        90       100       110       120       130       140       150       160       170       180 m046.pepRSNVKGDAPLPKTVWTSRRLPVSCNAFSSMSITVTSLLGMAARFCATVEPTCPLPKMRIF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a046RSNVKGDAPLPKTVWTSRRLPVSCNAFSSMSITVTSLLGMAARFCATVEPTCPLPKMRIF       130       140       150       160       170       180 m046.pepTVWVAEX ||||||| a046 TVWVAEXComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 046 shows 97.3% identity over a 185 aa overlap with a predicted ORF(ORF 046.ng) from N. gonorrhoeae:

m046/g046         10        20        30        40        50        60m046.pep MSAMLRPTSXPXXRACMMTIRTRSSAKRKTCNAPGQSIRPASCSVTSCSGLMVSVMPNME||||||||| |  ||||||||||||||||||||||||||||||||||||||||||||||| g046MSAMLRPTSSPPRRACMMTIRTRSSAKRKTCNAPGQSIRPASCSVTSCSGLMVSVMPNME        10        20        30        40        50        60        70        80        90       100       110       120 m046.pepRLPFSLFSSLGLRYSRYSLERTRAMRPGMLNRSAATLQATMLVSSLRESASSKSASSAPA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g046RLPFSLFSSLGLRYSRYSLERTRAMRPGMLNRSAATLQATMLVSSLRESASSKSASSAPA        70        80        90       100       110       120       130       140       150       160       170       180 m046.pepRSNVKGDAPLPKTVWTSRRLPVSCNAFSSMSITVTSLLGMAARFCATVEPTCPLPKMRIF| |||||||||||||||||||||||||||||||||||| ||||||||||||||||||||| g046RYNVKGDAPLPKTVWTSRRLPVSCNAFSSMSITVTSLLVMAARFCATVEPTCPLPKMRIF       130       140       150       160       170       180 m046.pepTVWVAEX ||||| g046 TVWVAGXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 193>:

g047.seq 1 ATGGTCATCA TACAGGCGcg gcGCGGCGGG CTGCTTGTCG GACGCAGCAT 51TGCCGACATC GCCCAAGATT TGCCCGACGG GGCCGACTGC CAAATCTGCG 101 CCGTTTACCGCAACAACCGC CTCATCGTCC CCGCGCCGCA AACCGTCATC 151 ATCGAAGGCG ACGAAATCCTGTTTGCCGCC GCCGCCGAAA ACATCGGGGC 201 GGTCATACCc gaATTGCGCC CCAAAGAAACCAGCACCCGC CGCATCATGA 251 TTGCCGGCGG CGGCAACATc tgctACCGCC TCGCCAAGCAGCTCGAACAC 301 GCATAcaacG TCAAAATCAT CGAATGCCGG CCGCGCcgtg ccgaATGGAT351 AGCCGAAAAC ctcgAcaaCA CCCTCGTCCT GCAAGGTTCG Gcaaccgacg 401aAaccctgct cgAcaacgaa tacatcgacg aaatcgaCGT ATTCTGCGCC 451 CTGACCAACGACGACGAAAG CAACATTAtg tCCGCCCTTT TGGCGAAAAA 501 CCTcggcgCG AAGCgcgtcatcggCATCGT CAACCGCTCA AGCTACGTCG 551 ATTTGCTCGA AGGCAACAAA ATCGACATCGTCGTCTCCCC CCACCTCATC 601 ACCATCGGCT CGATACTCGC CCACATCCGG CGCGGCGACATCGTTGCCGT 651 CCACCCCATC CGGCGCGGCA CGGCGGAAGC CATCGAAGTC GTCGCGCACG701 GCGACAAAAA AACTTCCGCC ATCATCGGCA GGCGCATCAG CGGCATCAAA 751TGGCCCGAAG GCTGCCACAT TGCCGCCGTC GTCCGCGCCG GAACCGGCGA 801 AACCATTATGGGACACCATA CCGAAACCGT CATCCAAGAC GGTGACCACA 851 TCATCTTTTT CGTCTCGCGCCGGCGCATCC TGAACGAACT GGAGAAACTC 901 ATCCAAGTCA AAATGGGCTT TTTCGGATAAThis corresponds to the amino acid sequence <SEQ ID 194; ORF 047.ng>:

g047.pep 1 MVIIQARRGG LLVGRSIADI AQDLPDGADC QICAVYRNNR LIVPAPQTVI 51IEGDEILFAA AAENIGAVIP ELRPKETSTR RIMIAGGGNI CYRLAKQLEH 101 AYNVKIIECRPRRAEWIAEN LDNTLVLQGS ATDETLLDNE YIDEIDVFCA 151 LTNDDESNIM SALLAKNLGAKRVIGIVNRS SYVDLLEGNK IDIVVSPHLI 201 TIGSILAHIR RGDIVAVHPI RRGTAEAIEVVAHGDKKTSA IIGRRISGIK 251 WPEGCHIAAV VRAGTGETIM GHHTETVIQD GDHIIFFVSRRRILNELEKL 301 IQVKMGFFG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 195>:

m047.seq 1 ATGGTCATCA TACAGgCGcG C..syGCGGA sTGCTTGTCG GACGCAGCAT 51TGCCGACATC GCCCAAGATT TGCCCGACGG GGCCGACTGC CAAATCTGCG 101 CCGTTTACCGCAACAACCGC CTCATCGTCC CCGCGCCGCA AACCGTCATC 151 ATCGAAGGCG ACGAAATCCTATTTGCCGCC GCCGCCGAAA ACATCGGCGC 201 GGTCATACCC GAATTGCGCC CCAAAGAAACCCAAAGAAAC CAGCcCmgmm 251 GcATCATGAT TkCCGGCGGC GGCAACATCG GCTACCGTCTCGCCAAGCAG 301 CTCGAACACG CATACAACGT yAAAATCATC GAATGCCGGC CGCGCCGTGC351 CGAATGGATA GCCGAAAACC TCGACAACAC CCTCGTCyTG CAAGGTTCGG 401CAACCGACGA AACCCTGCTC GACAACGAAT ACATCGACGA AATCGACGTA 451 TTCTGCGCCCTGACCAACGA CGACGAAAGC AACATTATGT CCGCCCTTTT 501 GGCGAaAAAC CTCGGCGCGAAGCGCGTCAT CGGCATCGTC AACCGCTCAA 551 GCTACGTCGA TTTGCTCGAA GGCAACAAAATCGACATCGT CGTCTCCCCC 601 CACCTCATCA CCATCGGCTC GATACTCGCC CACATCCGGCGCGGCGACAT 651 CGTTGCCGTC CACCCCATCC GGCGCGGCAC GGCGGAAGCC ATCGAAGTCG701 TCGCACACGG CGACAAAAAA ACTTCCGCCA TCATCGGCAG GCGCATCAGC 751GGCATCAAAT GGCCCGAAGG CTGCCACATT GCCGCCGTCG TCCGCGCCGG 801 AACCGGCGAAACCATTATGG GACACCATAC CGAAACCGTC ATCCAAGACG 851 GCGACCACAT CATCTTTTTCGTCTCGCGCC GGCGCATCCT GAACGAACTG 901 GAAAAACTCA TCCAGGTCAA AATGGGCTTTTTCGGATAAThis corresponds to the amino acid sequence <SEQ ID 196; ORF 047>:

m047.pep 1 MVIIQARXXG XLVGRSIADI AQDLPDGADC QICAVYRNNR LIVPAPQTVI 51IEGDEILFAA AAENIGAVIP ELRPKETQRN QPXXIMIXGG GNIGYRLAKQ 101 LEHAYNVKIIECRPRRAEWI AENLDNTLVL QGSATDETLL DNEYIDEIDV 151 FCALTNDDES NIMSALLAKNLGAKRVIGIV NRSSYVDLLE GNKIDIVVSP 201 HLITIGSILA HIRRGDIVAV HPIRRGTAEAIEVVAHGDKK TSAIIGRRIS 251 GIKWPEGCHI AAVVRAGTGE TIMGHHTETV IQDGDHIIFFVSRRRILNEL 301 EKLIQVKMGF FG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 197>:

a047.seq 1 ATGGTCATCA TACAGGCGCG GCGCGGCGGA CTGCTTGTCG GACGCAGCAT 51TGCCGACATC GCCCAAGATT TGCCCGACGG GGCCGACTGC CAAATCTGCG 101 CCGTTTACCGCAACAACCGC CTCATCGTCC CCGCGCCGCA AACCGTCATC 151 ATCGAAGGCG ACGAAATCCTATTTGCCGCC GCCGCCGAAA ACATCGGCGC 201 GGTCATACCC GAATTGCGCC CCAAAGAAACCAGCACCCGC CGCATCATGA 251 TTGCCGGCGG CGGCAACATC GGCTACCGTC TCGCCAAGCAGCTCGAACAC 301 GCATACAACG TCAAAATCAT CGAATGCCGG CCGCGCCGTG CCGAATGGAT351 AGCCGAAAAC CTCGACAACA CCCTCGTCCT GCAAGGTTCG GCAACCGACG 401AAACCCTGCT CGACAACGAA TACATCGACG AAATCGACGT ATTCTGCGCC 451 CTGACCAACGACGACGAAAG CAACATTATG TCCGCCCTTT TGGCGAAAAA 501 CCTCGGCGCG AAGCGCGTCATCGGCATCGT CAACCGCTCA AGCTACGTCG 551 ATTTGCTCGA AGGCAACAAA ATCGACATCGTCGTCTCCCC CCACCTCATC 601 ACCATCGGCT CGATACTCGC CCACATCCGG CGCGGCGACATCGTTGCCGT 651 CCACCCCATC CGGCGCGGCA CGGCGGAAGC CATCGAAGTC GTCGCACACG701 GCGACAAAAA AACTTCCGCC ATCATCGGCA GGCGCATCAG CGGCATCAAA 751TGGCCCGAAG GCTGCCACAT TGCCGCCGTC GTCCGCGCCG GAACCGGCGA 801 AACCATTATGGGACACCATA CCGAAACCGT CATCCAAGAC GGCGACCACA 851 TCATCTTTTT CGTCTCGCGCCGGCGCATCC TGAACGAACT GGAAAAACTC 901 ATCCAAGTCA AAATGGGCTT TTTCGGATAAThis corresponds to the amino acid sequence <SEQ ID 198; ORF 047.a>:

a047.pep 1 MVIIQARRGG LLVGRSIADI AQDLPDGADC QICAVYRNNR LIVPAPQTVI 51IEGDEILFAA AAENIGAVIP ELRPKETSTR RIMIAGGGNI GYRLAKQLEH 101 AYNVKIIECRPRRAEWIAEN LDNTLVLQGS ATDETLLDNE YIDEIDVFCA 151 LTNDDESNIM SALLAKNLGAKRVIGIVNRS SYVDLLEGNK IDIVVSPHLI 201 TIGSILAHIR RGDIVAVHPI RRGTAEAIEVVAHGDKKTSA IIGRRISGIK 251 WPEGCHIAAV VRAGTGETIM GHHTETVIQD GDHIIFFVSRRRILNELEKL 301 IQVKMGFFG* m047/a047 96.5% identity over a 312 aa overlap        10        20        30        40        50        60 m047.pepMVIIQARXXGXLVGRSIADIAQDLPDGADCQICAVYRNNRLIVPAPQTVIIEGDEILFAA|||||||  | ||||||||||||||||||||||||||||||||||||||||||||||||| a047MVIIQARRGGLLVGRSIADIAQDLPDGADCQICAVYRNNRLIVPAPQTVIIEGDEILFAA        10        20        30        40        50        60        70        80        90       100       110       120 m047.pepAAENIGAVIPELRPKETQRNQPXXIMIXGGGNIGYRLAKQLEHAYNVKIIECRPRRAEWI|||||||||||||||||:  :   ||| |||||||||||||||||||||||||||||||| a047AAENIGAVIPELRPKETSTRR---IMIAGGGNIGYRLAKQLEHAYNVKIIECRPRRAEWI        70        80           90       100       110       130       140       150       160       170       180 m047.pepAENLDNTLVLQGSATDETLLDNEYIDEIDVFCALTNDDESNIMSALLAKNLGAKRVIGIV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a047AENLDNTLVLQGSATDETLLDNEYIDEIDVFCALTNDDESNIMSALLAKNLGAKRVIGIV120       130       140       150       160       170       190       200       210       220       230       240 m047.pepNRSSYVDLLEGNKIDIVVSPHLITIGSILAHIRRGDIVAVHPIRRGTAEAIEVVAHGDKK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a047NRSSYVDLLEGNKIDIVVSPHLITIGSILAHIRRGDIVAVHPIRRGTAEAIEVVAHGDKK180       190       200       210       220       230       250       260       270       280       290       300 m047.pepTSAIIGRRISGIKWPEGCHIAAVVRAGTGETIMGHHTETVIQDGDHIIFFVSRRRILNEL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a047TSAIIGRRISGIKWPEGCHIAAVVRAGTGETIMGHHTETVIQDGDHIIFFVSRRRILNEL240       250       260       270       280       290        310m047.pep EKLIQVKMGFFGX ||||||||||||| a047 EKLIQVKMGFFGX 300       310Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 047 shows 96.2% identity over a 312 aa overlap with a predicted ORF(ORF 047.ng) from N. gonorrhoeae:

m047/g045 m047.pepMVIIQARXXGXLVGRSIADIAQDLPDGADCQICAVYRNNRLIVPAPQTVIIEGDEILFAA 60|||||||  | ||||||||||||||||||||||||||||||||||||||||||||||||| g047MVIIQARRGGLLVGRSIADIAQDLPDGADCQICAVYRNNRLIVPAPQTVIIEGDEILFAA 60 m047.pepAAENIGAVIPELRPKETQRNQPXXIMIXGGGNIGYRLAKQLEHAYNVKIIECRPRRAEWI 120|||||||||||||||||:  :   ||| ||||| |||||||||||||||||||||||||| g047AAENIGAVIPELRPKETSTRR---IMIAGGGNICYRLAKQLEHAYNVKIIECRPRRAEWI 117m047.pep AENLDNTLVLQGSATDETLLDNEYIDEIDVFCALTNDDESNIMSALLAKNLGAKRVIGIV180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g047AENLDNTLVLQGSATDETLLDNEYIDEIDVFCALTNDDESNIMSALLAKNLGAKRVIGIV 177m047.pep NRSSYVDLLEGNKIDIVVSPHLITIGSILAHIRRGDIVAVHPIRRGTAEAIEVVAHGDKK240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g047NRSSYVDLLEGNKIDIVVSPHLITIGSILAHIRRGDIVAVHPIRRGTAEAIEVVAHGDKK 237m047.pep TSAIIGRRISGIKWPEGCHIAAVVRAGTGETIMGHHTETVIQDGDHIIFFVSRRRILNEL300 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g047TSAIIGRRISGIKWPEGCHIAAVVRAGTGETIMGHHTETVIQDGDHIIFFVSRRRILNEL 297m047.pep EKLIQVKMGFFGX 313 ||||||||||||| g047 EKLIQVKMGFFGX 310The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 199>:

g048.seq 1 ATGCTCGACA AAGGCGAGGA GTTGCCCGTC GATTTCACCA ACCGCCTGAT 51TTACTACGTc ggcCCcgTCG ATCCGGTCGG CGATGAAGTC GTCGGTCCCG 101 CAGGTCCGACCACAGCCACC CGCATGGACA AATTTACCCG CCAAATGCTC 151 AAACAAACCG GCCTCTTGGGCATGATCGGC AAATCCGagc gcgGcgcggc 201 cacctGCGAA GCcatCGCCG ACAACAAGGCCGTGTACCTC ATGGCAGTCG 251 GCGGCGCGGC ATACCTCGTG GCAAAAGCCA TCAAATCTTCCAAAGTCTTG 301 GCGTTCCCCG AATTGGGTAT GGAAGCCGTT TACGAATTTG AAGTCAAAGA351 TATGCCCGTA ACCGTCGCCG TGGACAGCAA AGGCGAATCC ATCCACGCCA 401CCGCCCCGCG CAAATGGCAG GCGAAAATCG GCATCATCCC CGTCGAGTCT 451 TGAThis corresponds to the amino acid sequence <SEQ ID 200; ORF 048.ng>:

g048.pep 1 MLDKGEELPV DFTNRLIYYV GPVDPVGDEV VGPAGPTTAT RMDKFTRQML 51KQTGLLGMIG KSERGAATCE AIADNKAVYL MAVGGAAYLV AKAIKSSKVL 101 AFPELGMEAVYEFEVKDMPV TVAVDSKGES IHATAPRKWQ AKIGIIPVES 151 *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 201>:

m048.seq 1 ATGCTCAACA AAGGCGAAGA ATTGCCCGTC GATTTCACCA ACCGCCTGAT 51TTACTACGTC GGCCCCGTCG ATCCGGTCGG CGATGAAGTC GTCGGTCCGG 101 CAGGTCCGACCACAGCCACC CGCATGGACA AATTCACCCG CCAAATGCTC 151 GAACAAACCG ACCTCTTGGGCATGATCGGC AAATCCGAGC GCGGCGTGGC 201 CACCTGCGAA GCCATCGCCG ACAACAAAGCCGTGTACCTC ATGGCAGTCG 251 GCGGCGCGGC GTATCTCGTG GCAAAAGCCA TCAAATCTTCCAAAGTCTTG 301 GCGTTCCCCG AATTGGGCAT GGAAGCCATT TACGAATTTG AAGTCAAAGA351 CATGCCCGTA ACCGTCGCCG TAGATAGCAA AGGCGAATCC ATCCACGCCA 401CCGCCCCGCG CAAATGGCAG GCGAAAATCG GCATCATCCC CGTCGAATCT 451 TGAThis corresponds to the amino acid sequence <SEQ ID 202; ORF 048>:

m048.pep 1 MLNKGEELPV DFTNRLIYYV GPVDPVGDEV VGPAGPTTAT RMDKFTRQML 51EQTDLLGMIG KSERGVATCE AIADNKAVYL MAVGGAAYLV AKAIKSSKVL 101 AFPELGMEAIYEFEVKDMPV TVAVDSKGES IHATAPRKWQ AKIGIIPVES 151 *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 203>:

a048.seq 1 ATGCTCGACA AAGGCGAAGA ATTGCCCGTC GATTTCACCA ACCGCCTGAT 51TTACTACGTC GGCCCCGTCG ATCCGGTCGG CGACGAAATC GTCGGCCCAG 101 CAGGTCCGACCACCGCCACC CGCATGGACA AATTCACCCG CCAAATGCTC 151 GAACAAACCG ACCTCTTGGGCATGATCGGC AAATCCGAGC GCGGCGCGGC 201 CACCTGCGAA GCCATCGCCG ACAACAAAGCCGTGTACCTC ATGGCAGTCG 251 GCGGCGCGGC GTATCTCGTG GCAAAAGCCA TCAAATCTTCCAAAGTCTTG 301 GCGTTCCCCG AATTGGGCAT GGAAGCCATT TACGAATTTG AAGTCAAAGA351 CATGCCCGTA ACCGTCGCCG TAGACAGCAA AGGCGAATCC ATCCACGCCA 401CCGCCCCGCC CCAATGGCAG GCGAAAATCG GCATCATCCC CGTCAAATCT 451 TGAThis corresponds to the amino acid sequence <SEQ ID 204; ORF 048.a>:

a048.pep 1 MLDKGEELPV DFTNRLIYYV GPVDPVGDEI VGPAGPTTAT RMDKFTRQML 51EQTDLLGMIG KSERGAATCE AIADNKAVYL MAVGGAAYLV AKAIKSSKVL 101 AFPELGMEAIYEFEVKDMPV TVAVDSKGES IHATAPPQWQ AKIGIIPVKS 151 * m048/a048 96.0%identity over a 150 aa overlap        10        20        30        40        50        60 m048.pepMLNKGEELPVDFTNRLIYYVGPVDPVGDEVVGPAGPTTATRMDKFTRQMLEQTDLLGMIG||:||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| a048MLDKGEELPVDFTNRLIYYVGPVDPVGDEIVGPAGPTTATRMDKFTRQMLEQTDLLGMIG        10        20        30        40        50        60        70        80        90       100       110       120 m048.pepKSERGVATCEAIADNKAVYLMAVGGAAYLVAKAIKSSKVLAFPELGMEAIYEFEVKDMPV|||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||| a048KSERGAATCEAIADNKAVYLMAVGGAAYLVAKAIKSSKVLAFPELGMEAIYEFEVKDMPV        70        80        90       100       110       120       130       140       150 m048.pep TVAVDSKGESIHATAPRKWQAKIGIIPVESX|||||||||||||||| :||||||||||:|| a048 TVAVDSKGESIHATAPPQWQAKIGIIPVKSX       130       140       150Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 048 shows 96.4% identity over a 150 aa overlap with a predicted ORF(ORF 048.ng) from N. gonorrhoeae:

m048/g048         10        20        30        40        50        60m048.pep MLNKGEELPVDFTNRLIYYVGPVDPVGDEVVGPAGPTTATRMDKFTRQMLEQTDLLGMIG||:|||||||||||||||||||||||||||||||||||||||||||||||:|| |||||| g048MLDKGEELPVDFTNRLIYYVGPVDPVGDEVVGPAGPTTATRMDKFTRQMLKQTGLLGMIG        10        20        30        40        50        60        70        80        90       100       110       120 m048.pepKSERGVATCEAIADNKAVYLMAVGGAAYLVAKAIKSSKVLAFPELGMEAIYEFEVKDMPV|||||:|||||||||||||||||||||||||||||||||||||||||||:|||||||||| g048KSERGAATCEAIADNKAVYLMAVGGAAYLVAKAIKSSKVLAFPELGMEAVYEFEVKDMPV        70        80        90       100       110       120       130       140       150 m048.pep TVAVDSKGESIHATAPRKWQAKIGIIPVESX||||||||||||||||||||||||||||||| g048 TVAVDSKGESIHATAPRKWQAKIGIIPVESX       130       140       150The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 205>:

g049.seq 1 ATGCGGGCGC AGGCGTTTGA TCAACCGTTC GGTCAGCTCC TGTTCGGACA 51GGCAGAACAC TTCGCGCCGG TTGACGGCTT TCGGGTTCAG GATATTGATT 101 TGGACGGGCATCAACGCCTC TTCCGCACCG CCTTCGCCGT TTTCCGCAAC 151 CCCGTCTGCC GCCGTACCGGATTCTGCCGC ATCGGCGTTT TCCCCGCCCT 201 CAATCTGTGC GGTTTCAAAT TCGGCACTGTCTTTTTTGGC ATCGAACCGG 251 ATTCTCCGCC GCGATTCGAT GTGTTTTTCC GAAAccggcatTTGCAGGGA 301 AGCCTgcgcg TTGAGCCAGT TTTCCTGAAG GACGATCATC GGGTCGGTTT351 CGACTTCCTC GCCGCAATCG GCAACGGCgc tGTTGTGTTC TTCCTGCCAT 401TTCTTCAGAT ACGCCTTTAAThis corresponds to the amino acid sequence <SEQ ID 206; ORF 049.ng>:

g049.pep 1 MRAQAFDQPF GQLLFGQAEH FAPVDGFRVQ DIDLDGHQRL FRTAFAVFRN 51PVCRRTGFCR IGVFPALNLC GFKFGTVFFG IEPDSPPRFD VFFRNRHLQG 101 SLRVEPVFLKDDHRVGFDFL AAIGNGAVVF FLPFLQIRL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 207>:

m049.seq (partial) 1 ATGCGGGCGC AGGCGTTTGA TCAGCCGTTC GGTCAGCTCCTGTTCGGACA 51 GGCAGAACAC TTCGCGCCGG TTGACGGCTT TCGGGTTCAG GATATTGATT 101TGGACGGGCA TCAACGTTTC TTCCGCATCG TTTTCCCCGT TTTCCGAAAC 151 CGCCGGCTCATTCGTGCCGG ATTCTGCCTC GTCGGCGTTT TCCCCGCTTT 201 CAATCTGTCC GGTTTCAAATTCGACACTGT CTTTTTTGGT ATCAAACCGG 251 ATTCTCCGCC GCGATTCGAT GTGTTTTTCCGAAACCGACA TTTGCAGGGA 301 AGCCTGCGCG TTGAGCCAGT TTTCCTGAAG GACGATCATCGGGTCGGTTT 351 CGACTTCCTC GCCGCAATCG GCAACGGCGG CATTGTGTTC CTCCTGCCAT401 TTTTTCAGAT ACGCCTT...This corresponds to the amino acid sequence <SEQ ID 208; ORF 049>:

m049.pep (partial) 1 MRAQAFDQPF GQLLFGQAEH FAPVDGFRVQ DIDLDGHQRFFRIVFPVFRN 51 RRLIRAGFCL VGVFPAFNLS GFKFDTVFFG IKPDSPPRFD VFFRNRHLQG 101SLRVEPVFLK DDHRVGFDFL AAIGNGGIVF LLPFFQIRL...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 209>:

a049.seq 1 ATGCGGGCGC AGGCGTTTGA TCAGCCGTTC GGTCAGCTCC TGTTCGGACA 51GGCAGAACAC TTCGCGCCGG TTGACGGCTT TCGGGTTCAG AATATTGATT 101 TGGACGGGCATCAACGCTTC TTCCGCACCG CCTTCGCCGT TTTCCGCAAC 151 CCCGTCTGCC GCCGTACCCGATTCTGCCGC ATCGGCGTTT TCCCCGCCTT 201 CAATCTGTCC GGTTTCAAAT TCGGCACTGTCTTTTTTGGC ATCAAACCGG 251 ATTCTCCGCC GCGATTCGAT GTGTTTTTCC GAAACCGACATTTGCAGGGA 301 AGCCTGCGCG TTGAGCCAGT TTTCCTGAAG GACGATCATC GGGTCGGTTT351 CGACTTCCTC GCCGCAATCG GCAACGGCGG CATTGTGTTC CTCCTGCCAT 401TTTTTCAGAT ACGCCTTThis corresponds to the amino acid sequence <SEQ ID 210; ORF 049.a>:

a049.pep 1 MRAQAFDQPF GQLLFGQAEH FAPVDGFRVQ NIDLDGHQRF FRTAFAVFRN 51PVCRRTRFCR IGVFPAFNLS GFKFGTVFFG IKPDSPPRFD VFFRNRHLQG 101 SLRVEPVFLKDDHRVGFDFL AAIGNGGIVF LLPFFQIRL m049/a049 90.6% identity over a 139 aaoverlap         10        20        30        40        50        60m049.pep MRAQAFDQPFGQLLFGQAEHFAPVDGFRVQDIDLDGHQRFFRIVFPVFRNRRLIRAGFCL||||||||||||||||||||||||||||||:||||||||||| :| ||||    |: || a049MRAQAFDQPFGQLLFGQAEHFAPVDGFRVQNIDLDGHQRFFRTAFAVFRNPVCRRTRFCR        10        20        30        40        50        60        70        80        90       100       110       120 m049.pepVGVFPAFNLSGFKFDTVFFGIKPDSPPRFDVFFRNRHLQGSLRVEPVFLKDDHRVGFDFL:||||||||||||| ||||||||||||||||||||||||||||||||||||||||||||| a049IGVFPAFNLSGFKFGTVFFGIKPDSPPRFDVFFRNRHLQGSLRVEPVFLKDDHRVGFDFL        70        80        90       100       110       120       130      139 m049.pep AAIGNGGIVFLLPFFQIRL |||||||||||||||||||a049 AAIGNGGIVFLLPFFQIRL        130Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 049 shows 86.3% identity over a 139 aa overlap with a predicted ORF(ORF 049.ng) from N. gonorrhoeae:

m049/g049         10        20        30        40        50        60m049.pep MRAQAFDQPFGQLLFGQAEHFAPVDGFRVQDIDLDGHQRFFRIVFPVFRNRRLIRAGFCL|||||||||||||||||||||||||||||||||||||||:|| :| ||||    |:||| g049MRAQAFDQPFGQLLFGQAEHFAPVDGFRVQDIDLDGHQRLFRTAFAVFRNPVCRRIGFCR        10        20        30        40        50        60        70        80        90       100       110       120 m049.pepVGVFPAFNLSGFKFDTVFFGIKPDSPPRFDVFFRNRHLQGSLRVEPVFLKDDHRVGFDFL:|||||:|| |||| ||||||:|||||||||||||||||||||||||||||||||||||| g049IGVFPALNLCGFKFGTVFFGIEPDSPPRFDVFFRNRHLQGSLRVEPVFLKDDHRVGFDFL        70        80        90       100       110       120       130      139 m049.pep AAIGNGGIVFLLPFFQIRL ||||||::||:|||:||||g049 AAIGNGAVVFFLPFLQIRLX        130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 211>:

g050.seq 1 atgggcgCGG GCTGGTGTCC TCCCGGCATC TTGGGCATCG GCATCGGCGg 51cacgcccGAA AAAGccgtgt TGATGGcaaA AGAATCCCTG ATGAGCCACA 101 TCGAcatCcaaGaATTGCAG GAAAAAGCCG CGTccggggc ggaattgtcc 151 accaccgaAG ccCTGCGCCTcGAACTCTTT GAAAAGGTCA ACGCGCTGGG 201 CATCGGCGCG CAAGGCTTGG GCGGTCTGACCACCGTGTTG GACGTGAAAA 251 TCCTCGATTA CCCGACCCAT GCCGCCTCCA AACCGATTGCCATGATTCCC 301 AACTGTGCcg ccacCCGcca cgtcgAATTT GAATTGgACG GCTCAGGtcc351 TGTCGAactc acgccGCcgc gtgtCGAAGA CTGAThis corresponds to the amino acid sequence <SEQ ID 212; ORF 050.ng>:

g050.pep 1 MGAGWCPPGI LGIGIGGTPE KAVLMAKESL MSHIDIQELQ EKAASGAELS 51TTEALRLELF EKVNALGIGA QGLGGLTTVL DVKILDYPTH AASKPIAMIP 101 NCAATRHVEFELDGSGPVEL TPPRVED*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 213>:

m050.seq 1 ATGGGCGCGG GCTGGTGTCC TCCCGGCATC TTGGGTATCG GCATCGGCGG 51C..agCCgAA AAAGCCGTGC TGATGGCAAA AGAGTCCCTG ATGAGCCACA 101 TCGACATTCAAGAATTGCAG GAAAAGGCCG CGTCCGGCGC GgAATTGTCC 151 ACCACCGAAG CCCTGCGCCTCGAACTCTTT GAAAAAGTCA ACGCGCTGGG 201 CATCGGCGCA CAAGGCTTGG GCGGACTGACCACCGTGTTG GACGTGAAAA 251 TCCTCGATTA TCCGACCCAC GCCGCCTCCA AACCGATTGCCATGATTCCG 301 AACTGCGCCG CCACCCGCCA CGTCGAATTT GAATTGGACG GCTCAGGCCC351 TGTCGAACTC ACGCCGCCGC GCGTCGAAGA TGGCCCGATT TGAThis corresponds to the amino acid sequence <SEQ ID 214; ORF 050>:

m050.pep 1 MGAGWCPPGI LGIGIGGXAE KAVLMAKESL MSHIDIQELQ EKAASGAELS 51TTEALRLELF EKVNALGIGA QGLGGLTTVL DVKILDYPTH AASKPIAMIP 101 NCAATRHVEFELDGSGPVEL TPPRVEDGPI *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 215>:

a050.seq 1 ATGGGCGCGG GCTGGTGTCC TCCCGGCATC TTGGGCATCG GCATCGGCGG 51TACGCCCGAA AAAGCCGTGT TGATGGCGAA AGAATCCCTG ATGAGCCACA 101 TCGACATCCAAGAATTGCAG GAAAAAGCCG CGTCCGGCGC GGAATTGTCC 151 ACCACCGAAG CCCTGCGCCTCGAACTCTTT GAAAAAGTCA ACGCGCTAGG 201 CATCGGCGCG CAAGGCTTGG GCGGTCTGACCACCGTGTTG GACGTGAAAA 251 TCCTCGATTA CCCGACCCAC GCCGCCTCCA AACCGATTGCCATGATTCCG 301 AACTGCGCCG CCACCCGCCA CGTCGAATTT GAATTGGACG GCTCAGGCCC351 TGTCGAACTC ACGCCGCCGC GCGTCGAAGA CTGGCCCThis corresponds to the amino acid sequence <SEQ ID 216; ORF 050.a>:

a050.pep 1 MGAGWCPPGI LGIGIGGTPE KAVLMAKESL MSHIDIQELQ EKAASGAELS 51TTEALRLELF EKVNALGIGA QGLGGLTTVL DVKILDYPTH AASKPIAMIP 101 NCAATRHVEFELDGSGPVEL TPPRVEDWP m050/a050 97.7% identity over a 129 aa overlap        10        20        30        40        50        60 m050.pepMGAGWCPPGILGIGIGGXAEKAVLMAKESLMSHIDIQELQEKAASGAELSTTEALRLELF|||||||||||||||||: ||||||||||||||||||||||||||||||||||||||||| a050MGAGWCPPGILGIGIGGTPEKAVLMAKESLMSHIDIQELQEKAASGAELSTTEALRLELF        10        20        30        40        50        60        70        80        90       100       110       120 m050.pepEKVNALGIGAQGLGGLTTVLDVKILDYPTHAASKPIAMIPNCAATRHVEFELDGSGPVEL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a050EKVNALGIGAQGLGGLTTVLDVKILDYPTHAASKPIAMIPNCAATRHVEFELDGSGPVEL        70        80        90       100       110       120        130m050.pep TPPRVEDGPIX ||||||| | a050 TPPRVEDWPComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 050 shows 98.4% identity over a 127 aa overlap with a predicted ORF(ORF 050.ng) from N. gonorrhoeae:

m050/g050         10        20        30        40        50        60m050.pep MGAGWCPPGILGIGIGGXAEKAVLMAKESLMSHIDIQELQEKAASGAELSTTEALRLELF|||||||||||||||||: ||||||||||||||||||||||||||||||||||||||||| g050MGAGWCPPGILGIGIGGTPEKAVLMAKESLMSHIDIQELQEKAASGAELSTTEALRLELF        10        20        30        40        50        60        70        80        90       100       110       120 m050.pepEKVNALGIGAQGLGGLTTVLDVKILDYPTHAASKPIAMIPNCAATRHVEFELDGSGPVEL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g050EKVNALGIGAQGLGGLTTVLDVKILDYPTHAASKPIAMIPNCAATRHVEFELDGSGPVEL        70        80        90       100       110       120        130m050.pep TPPRVEDGPIX ||||||| g050 TPPRVEDXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 217>:

g050-1.seq 1 ATGACCGTTA TCAAGCAAGA AGACTTTATT CAAAGTATCT GCGATGCCTT 51CCAATTCATC AGCTACTACC ATCCAAAAGA CTACATCGAC GCGCTTTATA 101 AGGCGTGGCAGAAGGAAGAA AATCCCGCCG CCAAAGACGC GATGACGCAG 151 ATTTTGGTCA ACAGCCGTATGTGTGCCGAA AACAACCGCC CCATCTGCCA 201 AGACACAGGT ATCGCAACCG TCTTCCTCAAAGTCGGTATG GATGTGCAAT 251 GGGATGCGGA CATGAGCGTG GAAAAGATGG TTAACGAAGGCGTACGCCGC 301 GCCTACACTT GGGAAGGCAA CACCCTGCGC GCTTCCGTCC TCGCCGATCC351 GGCCGGCAAA CGCCAAAACA CCAAAGACAA CACCCCCGCC GTCATCCACA 401TGAGCATCGT GCCGGGCGGT AAAGTCGAAG TAACCTGCGC GGCAAAAGGC 451 GGCGGCTCTGAAAACAAATC CAAACTCGCT ATGCTCAACC CTTCCGACAA 501 CATCGTCGAT TGGGTATTGAAAACCATCCC GACGATGGGC GCGGGCTGGT 551 GTCCTCCCGG CATCTTGGGC ATCGGCATCGGCGGCAcgcC CGAAAAAGCC 601 GTGTTGATGG cgaAAGAATC CCTGATGAGC CACATCGACATCCAAGAATT 651 GCAGGAAAAA GCCGCGTCCG GCGCGGAATT GTCCACCACC GAAGCCCTGC701 GCCTCGAACT CTTTGAAAAG GTCAACGCGC TGGGCATCGG CGCGCAAGGC 751TTGGGCGGTC TGACCACCGT GTTGGACGTG AAAATCCTCG ATTACCCGAC 801 CCATGCCGCCTCCAAACCGA TTGCCATGAT TCCCAACTGT GCCGCCACCC 851 GCCACGTCGA ATTTGAATTGGACGGCTCAG GTCCTGTCGA ACTCACGCCG 901 CCGCGCGTCG AAGACTGACC CGATCTGACTTACAGCCCCG ACAACGGCAA 951 ACGCGTCGAT GTCGATAAGC TGACCAAAGA AGAAGTGGCAAGCTGGAAAA 1001 CCGGCGACGT ATTGCTGTTG AACGGCAAAA TCCTCACCGG CCGCGATGCC1051 GCGCACAAAC GCCTCGTCAA TATGCTCGAC AAAGGCGAGG AGTTGCCCGT 1101CGATTTCACC AACCGCCTGA TTTACTACGT CGGCCCCGTC GATCCGGTCG 1151 GCGATGAAGTCGTCGGTCCC GCAGGTCCGA CCACAGCCAC CCGCATGGAC 1201 AAATTTACCC GCCAAATGCTCAAACAAACC GGCCTCTTGG GCATGATCGG 1251 CAAATCCGAG CGCGGCGCGG CCACCTGCGAAGCCATCGCC GACAACAAGG 1301 CCGTGTACCT CATGGCAGTC GGCGGCGCGG CATACCTCGTGGCAAAAGCC 1351 ATCAAATCTT CCAAAGTCTT GGCGTTCCCC GAATTGGGTA TGGAAGCCGT1401 TTACGAATTT GAAGTCAAAG ATATGCCCGT AACCGTCGCC GTGGACAGCA 1451AAGGCGAATC CATCCACGCC ACCGCCCCGC GCAAATGGCA GGCGAAAATC 1501 GGCATCATCCCCGTCGAGTC TTGAThis corresponds to the amino acid sequence <SEQ ID 218; ORF 050-1.ng>:

g050-1.pep 1 MTVIKQEDFI QSICDAFQFI SYYHPKDYID ALYKAWQKEE NPAAKDAMTQ 51ILVNSRMCAE NNRPICQDTG IATVFLKVGM DVQWDADMSV EKMVNEGVRR 101 AYTWEGNTLRASVLADPAGK RQNTKDNTPA VIHMSIVPGG KVEVTCAAKG 151 GGSENKSKLA MLNPSDNIVDWVLKTIPTMG AGWCPPGILG IGIGGTPEKA 201 VLMAKESLMS HIDIQELQEK AASGAELSTTEALRLELFEK VNALGIGAQG 251 LGGLTTVLDV KILDYPTHAA SKPIAMIPNC AATRHVEFELDGSGPVELTP 301 PRVED*PDLT YSPDNGKRVD VDKLTKEEVA SWKTGDVLLL NGKILTGRDA351 AHKRLVNMLD KGEELPVDFT NRLIYYVGPV DPVGDEVVGP AGPTTATRMD 401KFTRQMLKQT GLLGMIGKSE RGAATCEAIA DNKAVYLMAV GGAAYLVAKA 451 IKSSKVLAFPELGMEAVYEF EVKDMPVTVA VDSKGESIHA TAPRKWQAKI 501 GIIPVES* g050-1/p14407sp|P14407|FUMB_ECOLI FUMARATE HYDRATASE CLASS I, ANAEROBIC(FUMARASE) >gi|280063|pir||B44511 fumarate hydratase (EC 4.2.1.2) fumB,iron-dependent - Escherichia coli >gi|146048 (M27058) anaerobic class Ifumarase (EC 4.2.1.2) [Escherichia coli] Length = 548 Score = 172 bits(432), Expect = 4e−42 Identities = 138/488 (28%), Positives = 216/488(43%), Gaps = 22/488 (4%) Query: 11QSICDAFQFISYYHPKDYIDALYKAWQKEENPAAKDAMTQILVNSRMCAENNRPICQDTG 70Q+  DA   +   H K     L+     E +   K    Q L NS + A+   P CQDTG Sbjct: 53QAFHDASFMLRPAHQKQVAAILHDPEASEND---KYVALQFLRNSEIAAKGVLPTCQDTG 109 Query:71 IATVFLKVGMDVQWDADMSVEKMVNEGVRRAYTWEGNTLRASVLADPAGKRQNTKDNTPA 130  A+  K G  V W      E+ +++GV   Y  E N   +   A    K  NT  N PA Sbjct: 110TAIIVGKKGQRV-WTGGGD-EETLSKGVYNTYI-EDNLRYSQNAALDMYKEVNTGTNLPA 166 Query:131 VIHMSIVPGGKVEVTCAAKGGGSENKSKL-----AMLNPSDNIVDWVLKTIPTMGAGWCP 185  I+  V G + +  C AKGGGS NK+ L     A+L P   + +++++ + T+G   CP Sbjct: 167QIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPG-KLKNFLVEKMRTLGTAACP 225 Query:186 PXXXXXXXXXTPEKAVLMAKESLMSHIDIQELQEKAASGAELSTTEALRLELFEKVNXXX 245P         T  +  L   +   +H    EL  +     +      L  EL E+ Sbjct: 226PYHIAFVIGGTSAETNLKTVKLASAHY-YDELPTEGNEHGQAFRDVQLEQELLEEAQKLG 284 Query:246 XXXXXXXXXTTVLDVKILDYPTHAASKPIAMIPNCAATRHVEFELDGSG----PVELTPP 301             D++++  P H AS P+ M  +C+A R+++ +++  G     +E  P Sbjct: 285LGAQFGGKYFAH-DIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLEHNPG 343 uery:302 RVEDXPDLTYSPDNGKRVDVDKLTKE---EVASWKTGDVLLLNGKILTGRDAAHKRLVNM 358+               +VD+++  KE   +++ +     L L G I+ GRD AH +L  + Sbjct: 344QYIPQELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKEL 403 Query:359 LDKGEELPVDFTNRLIYYXXXXXXXXXXXXXXXXXTTATRMDKFTRQMLKQTGLLGMIGK 418 +DG+ELP    +  IYY                 TTA RMD +   +    G + M+ K Sbjct: 404IDAGKELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAK 463 Query:419 SERGAATCEAIADNKAVYLMAVGG-AAYLVAKAIKSSKVLAFPELGMEAVYEFEVKDMPV 477  R     +A   +   YL ++GG AA L  ++IK  + +A+PELGMEA+++ EV+D P Sbjct: 464GNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPA 523 Query:478 TVAVDSKG 485  + VD KG Sbjct: 524 FILVDDKG 531The following partial DNA sequence was identified in N. meningitidis<SEQ ID 219>:

m050-1.seq 1 ATGACCGTCA TCAAACAGGA AGACTTTATC CAAAGCATTT GCGATGCCTT 51CCAATTCATC AGCTACTATC ATCCCAAAGA CTACATCGAC GCGCTTTATA 101 AGGCGTGGCAGAAGGAAGAA AATCCTGCCG CCAAAGACGC GATGACGCAG 151 ATTTTGGTCA ACAGCCGTATGTGTGCGGAA AACAACCGCC CCATCTGCCA 201 AGACACAGGT ATCGCAACCG TCTTCCTCAAAGTCGGTATG AACGTCCAAT 251 GGGATGCGGA CATGAGCGTG GAAGAGATGG TTAACGAAGGCGTACGCCGC 301 GCCTACACTT GGGAAGGCAA TACGCTGCGC GCTTCCGTCC TCGCCGATCC351 GGCCGGCAAA CGCCAAAACA CCAAAGACAA CACCCCCGCC GTCATCCATA 401TGAGCATCGT GCCGGGCGGT AAAGTCGAAG TAACCTGCGC GGCAAAAGGC 451 GGCGGCTCTGAAAACAAATC CAAACTCGCC ATGCTCAATC CTTCCGACAA 501 CATCGTCGAT TGGGTATTGAAAACCATCCC GACCATGGGC GCGGGCTGGT 551 GTCCTCCCGG CATCTTGGGT ATCGGCATCGGCGGCACGCC CGAAAAAGCC 601 GTGCTGATGG CAAAAGAGTC CCTGATGAGC CACATCGACATTCAAGAATT 651 GCAGGAAAAG GCCGCGTCCG GCGCGGAATT GTCCACCACC GAAGCCCTGC701 GCCTCGAACT CTTTGAAAAA GTCAACGCGC TGGGCATCGG CGCACAAGGC 751TTGGGCGGAC TGACCACCGT GTTGGACGTG AAAATCCTCG ATTATCCGAC 801 CCACGCCGCCTCCAAACCGA TTGCCATGAT TCCGAACTGC GCCGCCACCC 851 GCCACGTCGA ATTTGAATTGGACGGCTCAG GCCCTGTCGA ACTCACGCCG 901 CCGCGCGTCG AAGACTGGCC CGATTTGACTTACAGCCCCG ACAACGGCAA 951 ACGCGTCGAT GTCGACAAGC TGACCAAAGA AGAAGTGGCAAGCTGGAAAA 1001 CCGGCGACGT ATTGCTGTTG AACGGCAAAA TCCTCACCGG CCGCGATGCC1051 GCACACAAAC GCCTCGTCGA TATGCTCAAC AAAGGCGAAG AATTGCCCGT 1101CGATTTCACC AACCGCCTGA TTTACTACGT CGGCCCCGTC GATCCGGTCG 1151 GCGATGAAGTCGTCGGTCCG GCAGGTCCGA CCACAGCCAC CCGCATGGAC 1201 AAATTCACCC GCCAAATGCTCGAACAAACC GACCTCTTGG GCATGATCGG 1251 CAAATCCGAG CGCGGCGTGG CCACCTGCGAAGCCATCGCC GACAACAAAG 1301 CCGTGTACCT CATGGCAGTC GGCGGCGCGG CGTATCTCGTGGCAAAAGCC 1351 ATCAAATCTT CCAAAGTCTT GGCGTTCCCC GAATTGGGCA TGGAAGCCAT1401 TTACGAATTT GAAGTCAAAG ACATGCCCGT AACCGTCGCC GTAGATAGCA 1451AAGGCGAATC CATCCACGCC ACCGCCCCGC GCAAATGGCA GGCGAAAATC 1501 GGCATCATCCCCGTCGAATC TTGAThis corresponds to the amino acid sequence <SEQ ID 220; ORF 050-1>:

m050-1.pep 1 MTVIKQEDFI QSICDAFQFI SYYHPKDYID ALYKAWQKEE NPAAKDAMTQ 51ILVNSRMCAE NNRPICQDTG IATVFLKVGM NVQWDADMSV EEMVNEGVRR 101 AYTWEGNTLRASVLADPAGK RQNTKDNTPA VIHMSIVPGG KVEVTCAAKG 151 GGSENKSKLA MLNPSDNIVDWVLKTIPTMG AGWCPPGILG IGIGGTPEKA 201 VLMAKESLMS HIDIQELQEK AASGAELSTTEALRLELFEK VNALGIGAQG 251 LGGLTTVLDV KILDYPTHAA SKPIAMIPNC AATRHVEFELDGSGPVELTP 301 PRVEDWPDLT YSPDNGKRVD VDKLTKEEVA SWKTGDVLLL NGKILTGRDA351 AHKRLVDMLN KGEELPVDFT NRLIYYVGPV DPVGDEVVGP AGPTTATRMD 401KFTRQMLEQT DLLGMIGKSE RGVATCEAIA DNKAVYLMAV GGAAYLVAKA 451 IKSSKVLAFPELGMEAIYEF EVKDMPVTVA VDSKGESIHA TAPRKWQAKI 501 GIIPVES* m050-1/g050-198.2% identity in 507 aa overlap        10        20        30        40        50        60 m050-1.pepMTVIKQEDFIQSICDAFQFISYYHPKDYIDALYKAWQKEENPAAKDAMTQILVNSRMCAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g050-1MTVIKQEDFIQSICDAFQFISYYHPKDYIDALYKAWQKEENPAAKDAMTQILVNSRMCAE        10        20        30        40        50        60        70        80        90       100       110       120 m050-1.pepNNRPICQDTGIATVFLKVGMNVQWDADMSVEEMVNEGVRRAYTWEGNTLRASVLADPAGK||||||||||||||||||||:||||||||||:|||||||||||||||||||||||||||| g050-1NNRPICQDTGIATVFLKVGMDVQWDADMSVEKMVNEGVRRAYTWEGNTLRASVLADPAGK        70        80        90       100       110       120       130       140       150       160       170       180 m050-1.pepRQNTKDNTPAVIHMSIVPGGKVEVTCAAKGGGSENKSKLAMLNPSDNIVDWVLKTIPTMG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g050-1RQNTKDNTPAVIHMSIVPGGKVEVTCAAKGGGSENKSKLAMLNPSDNIVDWVLKTIPTMG       130       140       150       160       170       180       190       200       210       220       230       240 m050-1.pepAGWCPPGILGIGIGGTPEKAVLMAKESLMSHIDIQELQEKAASGAELSTTEALRLELFEK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g050-1AGWCPPGILGIGIGGTPEKAVLMAKESLMSHIDIQELQEKAASGAELSTTEALRLELFEK       190       200       210       220       230       240       250       260       270       280       290       300 m050-1.pepVNALGIGAQGLGGLTTVLDVKILDYPTHAASKPIAMIPNCAATRHVEFELDGSGPVELTP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g050-1VNALGIGAQGLGGLTTVLDVKILDYPTHAASKPIAMIPNCAATRHVEFELDGSGPVELTP       250       260       270       280       290       300       310       320       330       340       350       360 m050-1.pepPRVEDWPDLTYSPDNGKRVDVDKLTKEEVASWKTGDVLLLNGKILTGRDAAHKRLVDMLN||||| ||||||||||||||||||||||||||||||||||||||||||||||||||:||: g050-1PRVEDXPDLTYSPDNGKRVDVDKLTKEEVASWKTGDVLLLNGKILTGRDAAHKRLVNMLD       310       320       330       340       350       360       370       380       390       400       410       420 m050-1.pepKGEELPVDFTNRLIYYVGPVDPVGDEVVGPAGPTTATRMDKFTRQMLEQTDLLGMIGKSE|||||||||||||||||||||||||||||||||||||||||||||||:|| ||||||||| g050-1KGEELPVDFTNRLIYYVGPVDPVGDEVVGPAGPTTATRMDKFTRQMLKQTGLLGMIGKSE       370       380       390       400       410       420       430       440       450       460       470       480 m050-1.pepRGVATCEAIADNKAVYLMAVGGAAYLVAKAIKSSKVLAFPELGMEAIYEFEVKDMPVTVA||:|||||||||||||||||||||||||||||||||||||||||||:||||||||||||| g050-1RGAATCEAIADNKAVYLMAVGGAAYLVAKAIKSSKVLAFPELGMEAVYEFEVKDMPVTVA       430       440       450       460       470       480       490       500 m050-1.pep VDSKGESIHATAPRKWQAKIGIIPVESX|||||||||||||||||||||||||||| g050-1 VDSKGESIHATAPRKWQAKIGIIPVESX       490       500The following partial DNA sequence was identified in N. meningitidis<SEQ ID 221>:

a050-1.seq 1 ATGACCGTCA TCAAACAGGA AGACTTTATC CAAAGCATTT GCGATGCCTT 51CCAATTCATC AGCTACTACC ATCCCAAAGA CTACATCGAC GCGCTTTATA 101 AGGCGTGGCAGAAGGAAGAA AACCCCGCCG CCAAAGACGC GATGACGCAG 151 ATTTTGGTCA ACAGCCGCATGTGTGCCGAA AACAACCGCC CCATCTGCCA 201 AGATACCGGT ATCGCGACCG TGTTTTTGAAAGTCGGTATG GATGTGCAAT 251 GGGATGCAGA CATGAGCGTC GAAGAGATGG TTAACGAAGGCGTGCGCCGC 301 GCCTACACTT GGGAAGGCAA TACGCTGCGC GCTTCCGTTC TCGCCGACCC351 CGCCGGCAAA CGCCAAAATA CCAAAGACAA CACGCCCGCC GTCATCCATA 401TGAGCATCGT GCCGGGCGAC AAAGTCGAAG TAACCTGCGC GGCAAAAGGC 451 GGCGGTTCTGAAAACAAATC CAAACTCGCC ATGCTCAACC CTTCCGACAA 501 CATCGTCGAT TGGGTATTGAAAACCATTCC GACCATGGGC GCGGGCTGGT 551 GTCCTCCCGG CATCTTGGGC ATCGGCATCGGCGGTACGCC CGAAAAAGCC 601 GTGTTGATGG CGAAAGAATC CCTGATGAGC CACATCGACATCCAAGAATT 651 GCAGGAAAAA GCCGCGTCCG GCGCGGAATT GTCCACCACC GAAGCCCTGC701 GCCTCGAACT CTTTGAAAAA GTCAACGCGC TAGGCATCGG CGCGCAAGGC 751TTGGGCGGTC TGACCACCGT GTTGGACGTG AAAATCCTCG ATTACCCGAC 801 CCACGCCGCCTCCAAACCGA TTGCCATGAT TCCGAACTGC GCCGCCACCC 851 GCCACGTCGA ATTTGAATTGGACGGCTCAG GCCCTGTCGA ACTCACGCCG 901 CCGCGCGTCG AAGACTGGCC CGATTTGACTTACAGCCCCG ACAACGGCAA 951 ACGCGTCGAT GTCGACAAGC TGACCAAAGA AGAAGTGGCAAGCTGGAAAA 1001 CCGGCGACGT ATTGCTGTTG AACGGCAAAA TCCTCACCGG CCGCGATGCC1051 GCACACAAAC GCCTCGTCGA TATGCTCGAC AAAGGCGAAG AATTGCCCGT 1101CGATTTCACC AACCGCCTGA TTTACTACGT CGGCCCCGTC GATCCGGTCG 1151 GCGACGAAATCGTCGGCCCA GCAGGTCCGA CCACCGCCAC CCGCATGGAC 1201 AAATTCACCC GCCAAATGCTCGAACAAACC GACCTCTTGG GCATGATCGG 1251 CAAATCCGAG CGCGGCGCGG CCACCTGCGAAGCCATCGCC GACAACAAAG 1301 CCGTGTACCT CATGGCAGTC GGCGGCGCGG CGTATCTCGTGGCAAAAGCC 1351 ATCAAATCTT CCAAAGTCTT GGCGTTCCCC GAATTGGGCA TGGAAGCCAT1401 TTACGAATTT GAAGTCAAAG ACATGCCCGT AACCGTCGCC GTAGACAGCA 1451AAGGCGAATC CATCCACGCC ACCGCCCCGC CCCAATGGCA GGCGAAAATC 1501 GGCATCATCCCCGTCAAATC TTGAThis corresponds to the amino acid sequence <SEQ ID 222; ORF 050-1.a>:

a050-1.pep 1 MTVIKQEDFI QSICDAFQFI SYYHPKDYID ALYKAWQKEE NPAAKDAMTQ 51ILVNSRMCAE NNRPICQDTG IATVFLKVGM DVQWDADMSV EEMVNEGVRR 101 AYTWEGNTLRASVLADPAGK RQNTKDNTPA VIHMSIVPGD KVEVTCAAKG 151 GGSENKSKLA MLNPSDNIVDWVLKTIPTMG AGWCPPGILG IGIGGTPEKA 201 VLMAKESLMS HIDIQELQEK AASGAELSTTEALRLELFEK VNALGIGAQG 251 LGGLTTVLDV KILDYPTHAA SKPIAMIPNC AATRHVEFELDGSGPVELTP 301 PRVEDWPDLT YSPDNGKRVD VDKLTKEEVA SWKTGDVLLL NGKILTGRDA351 AHKRLVDMLD KGEELPVDFT NRLIYYVGPV DPVGDEIVGP AGPTTATRMD 401KFTRQMLEQT DLLGMIGKSE RGAATCEAIA DNKAVYLMAV GGAAYLVAKA 451 IKSSKVLAFPELGMEAIYEF EVKDMPVTVA VDSKGESIHA TAPPQWQAKI 501 GIIPVKS* a050-1/m050-198.4% identity in 507 aa overlap        10        20        30        40        50        60 a050-1.pepMTVIKQEDFIQSICDAFQFISYYHPKDYIDALYKAWQKEENPAAKDAMTQILVNSRMCAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m050-1MTVIKQEDFIQSICDAFQFISYYHPKDYIDALYKAWQKEENPAAKDAMTQILVNSRMCAE        10        20        30        40        50        60        70        80        90       100       110       120 a050-1.pepNNRPICQDTGIATVFLKVGMDVQWDADMSVEEMVNEGVRRAYTWEGNTLRASVLADPAGK||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||| m050-1NNRPICQDTGIATVFLKVGMNVQWDADMSVEEMVNEGVRRAYTWEGNTLRASVLADPAGK        70        80        90       100       110       120       130       140       150       160       170       180 a050-1.pepRQNTKDNTPAVIHMSIVPGDKVEVTCAAKGGGSENKSKLAMLNPSDNIVDWVLKTIPTMG||||||||||||||||||| |||||||||||||||||||||||||||||||||||||||| m050-1RQNTKDNTPAVIHMSIVPGGKVEVTCAAKGGGSENKSKLAMLNPSDNIVDWVLKTIPTMG       130       140       150       160       170       180       190       200       210       220       230       240 a050-1.pepAGWCPPGILGIGIGGTPEKAVLMAKESLMSHIDIQELQEKAASGAELSTTEALRLELFEK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m050-1AGWCPPGILGIGIGGTPEKAVLMAKESLMSHIDIQELQEKAASGAELSTTEALRLELFEK       190       200       210       220       230       240       250       260       270       280       290       300 a050-1.pepVNALGIGAQGLGGLTTVLDVKILDYPTHAASKPIAMIPNCAATRHVEFELDGSGPVELTP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m050-1VNALGIGAQGLGGLTTVLDVKILDYPTHAASKPIAMIPNCAATRHVEFELDGSGPVELTP       250       260       270       280       290       300       310       320       330       340       350       360 a050-1.pepPRVEDWPDLTYSPDNGKRVDVDKLTKEEVASWKTGDVLLLNGKILTGRDAAHKRLVDMLD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: m050-1PRVEDWPDLTYSPDNGKRVDVDKLTKEEVASWKTGDVLLLNGKILTGRDAAHKRLVDMLN       310       320       330       340       350       360       370       380       390       400       410       420 a050-1.pepKGEELPVDFTNRLIYYVGPVDPVGDEIVGPAGPTTATRMDKFTRQMLEQTDLLGMIGKSE||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| m050-1KGEELPVDFTNRLIYYVGPVDPVGDEVVGPAGPTTATRMDKFTRQMLEQTDLLGMIGKSE       370       380       390       400       410       420       430       440       450       460       470       480 a050-1.pepRGAATCEAIADNKAVYLMAVGGAAYLVAKAIKSSKVLAFPELGMEAIYEFEVKDMPVTVA||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m050-1RGVATCEAIADNKAVYLMAVGGAAYLVAKAIKSSKVLAFPELGMEAIYEFEVKDMPVTVA       430       440       450       460       470       480       490       500 a050-1.pep VDSKGESIHATAPPQWQAKIGIIPVKSX||||||||||||| :||||||||||:|| m050-1 VDSKGESIHATAPRKWQAKIGIIPVESX       490       500The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 223>:

g052.seq 1 ATGGCTTTGG TGGCGGAGGA AACGGAAATA TCCGCGCCGT GTTTCAAAGG 51CTGCGAGCCG ACGGGCGACA GCAGGCTGTT GTCCACCACC AAGAGCGCGC 101 CGATGCCGTGCGCCAATTCC GCCAAGGCTT CCAAGTCGGC CACTTCGCCC 151 AAGGGGTTGG ACGGCGTTTCCAAAAACAGC AGTTTGGTGT TGGCTTTGAC 201 GGCGGCTTTC CATTCATTTA TATCAGTCGGCGACACGCGG CTCACTCCGA 251 TGCCGAATTT GGTAACGATG TTATTGATAA AGCCGACGGTCGTGCCGAAC 301 AGGCTGCGGC TGGAAACCAC ATGGTCGCCC GCCTGCAGGA AGGTGAAAAA351 CGCCGCCTGAThis corresponds to the amino acid sequence <SEQ ID 224; ORF 052.ng>:

g052.pep 1 MALVAEETEI SAPCFKGCEP TGDSRLLSTT KSAPMPCANS AKASKSATSP 51KGLDGVSKNS SLVLALTAAF HSFISVGDTR LTPMPNLVTM LLIKPTVVPN 101 RLRLETTWSPACRKVKNAA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 225>:

m052.seq 1 ATGGCTTTGG TGGCGGAGGA AACGGAAATA TCCGCGCCGT GTTTCAAAGG 51CTGCGAGCCG ACGGGCGACA GCAGGCTGTT GTCCACCACC AAGAGCGCGC 101 CGATGCCGTGCGCCAATTCC GCCAAGGCTT CCAAGTCGGC CACTTCGCCC 151 AAGGGGTTGG ACGGCGTTTCCAAAAACAGC AGTTTGGTGT TGGCTTTGAC 201 GGCGGCTTTC CATTCATTTA TATCAGTCGGCGACACGCGG CTCACTCCGA 251 TGCCGAATTT GGTAACGATG TTATTGATAA AGCCGACGGTCGTGCCGAAC 301 AGGCTGCGGC TGGAAACCAC ATGGTCGCCC GCCTGCAGGA AGGTGAAAAA351 CGCCGCCTGAThis corresponds to the amino acid sequence <SEQ ID 226; ORF 052>:

m052.pep 1 MALVAEETEI SAPCFKGCEP TGDSRLLSTT KSAPMPCANS AKASKSATSP 51KGLDGVSKNS SLVLALTAAF HSFISVGDTR LTPMPNLVTM LLIKPTVVPN 101 RLRLETTWSPACRKVKNAA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 227>:

a052.seq 1 ATGGCTTTGG TCGCGGAGGA AACGGAAATA TCCGCGCCGT GTTTCAAAGG 51CTGAGAGCCG ACAGGCGACA GCAGGCTGTT GTCCACCACC AAGAGCGCGC 101 CGATGCCGTGCGCCAATTCC GCCAAGGCTT CCAAGTCGGC CACTTCTCCC 151 AAGGGATTGG ACGGCGTTTCCAAAAACAGC AGTTTGGTGT TGGCTTTGAC 201 GGCGGCTTTC CATTCGTTTA TATCAGTCGGCGACACGTGA CTCACTTCGA 251 TGCCGAATTT GGTAACGATG TTATTGATAA AGCCGACGGTCGTGCCGAAC 301 AGGCTGCGGC TGGAAATCAC ATGGTCGCCC GCCTGCAAAA AGGTGAAAAA351 CGCCGCCTGAThis corresponds to the amino acid sequence <SEQ ID 228; ORF 052.a>:

a052.pep 1 MALVAEETEI SAPCFKG*EP TGDSRLLSTT KSAPMPCANS AKASKSATSP 51KGLDGVSKNS SLVLALTAAF HSFISVGDT* LTSMPNLVTM LLIKPTVVPN 101 RLRLEITWSPACKKVKNAA* m052/a052 95.8% identity over a 119 aa overlap        10        20        30        40        50        60 m052.pepMALVAEETEISAPCFKGCEPTGDSRLLSTTKSAPMPCANSAKASKSATSPKGLDGVSKNS||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||| a052MALVAEETEISAPCFKGXEPTGDSRLLSTTKSAPMPCANSAKASKSATSPKGLDGVSKNS        10        20        30        40        50        60        70        80        90       100       110       120 m052.pepSLVLALTAAFHSFISVGDTRLTPMPNLVTMLLIKPTVVPNRLRLETTWSPACRKVKNAAX||||||||||||||||||| || |||||||||||||||||||||| ||||||:||||||| a052SLVLALTAAFHSFISVGDTXLTSMPNLVTMLLIKPTVVPNRLRLEITWSPACKKVKNAAX        70        80        90       100       110       120Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 052 shows 95.8% identity over a 119 aa overlap with a predicted ORF(ORF 052.ng) from N. gonorrhoeae:

m052/g052         10        20        30        40        50        60m052.pep MALVAEETEISAPCFKGCEPTGDSRLLSTTKSAPMPCANSAKASKSATSPKGLDGVSKNS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g052MALVAEETEISAPCFKGCEPTGDSRLLSTTKSAPMPCANSAKASKSATSPKGLDGVSKNS        10        20        30        40        50        60        70        80        90       100       110       120 m052.pepSLVLALTAAFHSFISVGDTWLTSMPNLATMLLIKPTVVPNRLRLEITWSPACKKVKNAAX||||||||||||||||||| || ||||:||||||||||||||||| ||||||:||||||| g052SLVLALTAAFHSFISVGDTRLTPMPNLVTMLLIKPTVVPNRLRLETTWSPACRKVKNAAX        70        80        90       100       110       120The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 229>:

g073.seq 1 ATGTGTATGC CATACGCAAT AAGGGTTTCA GACGGCATCT GCCGCATTTT 51TCCGCCGATG CCGTCTGAAA CACGCAATCA GCGCGCGAGT GCCTGTTTCA 101 AATCGTCAATCAAATCGCCA ACATATTCCA AACCGACCGA CAGGCGCACC 151 AGTCCGGGGC GGatacCGGCGGCGAGTTTT TCTTCGGGCT GCATCCTGCC 201 GTGCGTGGTT GTCCACGGAT TGGTGATGGTCGAGCGCACG TCGCCGAGGT 251 TGGCGGTACG GGAAAAGAGT TCCACGACTT TCCACGCGGCTGCTTGGTCG 301 GCGACTTCAA AACCGATGAC GATGCCGCCG CCGTTTTGCT GTTTGCGGAT351 AAGCTCCGCC TGCGGATGGT CGGGCAATCC GGTGTAGThis corresponds to the amino acid sequence <SEQ ID 230; ORF 073.ng>:

g073.pep 1 MCMPYAIRVS DGICRIFPPM PSETRNQRAS ACFKSSIKSP TYSKPTDRRT 51SPGRIPAASF SSGCILPCVV VHGLVMVERT SPRLAVREKS STTFHAAAWS 101 ATSKPMTMPPPFCCLRISSA CGWSGNPV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 231>:

m073.seq 1 ATGTGTATGC CATATAAGAT AAGGGTTTCA GACGGCATCT GCTGTCCAAT 51GCCGTCTGAA ACACGCAATC AGCGTGCGAG TGCCTGTTTC AAATCGTCAA 101 TCAAATCGCCAACATATTCC AAACCGACCG ACAGGCGCAC CAATCCGGGG 151 CGGATGTTGG CGGCGAGTTTTTCTTCGGGC TGCATCCTGC CGTGCGTGGT 201 TGTCCACGGG TGGGTAATGG TCGAGCGCACGTCACCGAGG TTGGCGGTGC 251 GGGAAAAGAG TTCCACGCCG TCCACAACTT TCCACGCCGCTTCTTGATCG 301 GCAACTTCAA AGCCGATGAC GATGCCGCCG CCGTTTTGCT GTTTGCGGAT351 AAGCGCCGCC TGAGGATGGT CGGACAATCC GGTGTAGThis corresponds to the amino acid sequence <SEQ ID 232; ORF 073>:

m073.pep 1 MCMPYKIRVS DGICCPMPSE TRNQRASACF KSSIKSPTYS KPTDRRTNPG 51RMLAASFSSG CILPCVVVHG WVMVERTSPR LAVREKSSTP STTFHAASXS 101 ATSKPMTMPPPFCCLRISAA XGWSDNPV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 233>:

a073.seq 1 ACGTGTATGT CATATAAGAT AAGGGTTTCA GACGGCATTT GCGGTGTTTT 51TCCGCCGATG CCGTCTGAA. CACGCAATCA GCGCGCGAGT GCCTGTTTCA 101 AATCGTCAATCAAATCGCCA ACATATTCCA AACCGACCGA CAGGCGCACC 151 AATCCGGGGC GGATGTTGGCGGCGAGTTTT TCTTCGGGCT GCATCCTGCC 201 GTGCGTGGTT GTCCACGGAT GGGTAATGGTCGAGCGCACG TCGCCGAGGT 251 TGGCGGTACG GGAGAAAAGT TCGACGCCGT CCACGACTTTCCACGCGGCT 301 GCTTGGTCGG CGACTTCAAA GCCGATGACG ATGCCGCCGC CGTTTTGCTG351 TTTGCGGATA AGCTCCGCCT GAGGATGGTC GGGTAATCCG GTGTAAThis corresponds to the amino acid sequence <SEQ ID 234; ORF 073.a>:

a073.pep 1 TCMSYKIRVS DGICGVFPPM PSEXRNQRAS ACFKSSIKSP TYSKPTDRRT 51NPGRMLAASF SSGCILPCVV VHGWVMVERT SPRLAVREKS STPSTTFHAA 101 AWSATSKPMTMPPPFCCLRI SSA*GWSGNP V* m073/a073 92.3% identity over a 130 aa overlap        10           20        30        40        50 m073.pepMCMPYKIRVSDGICC---PMPSETRNQRASACFKSSIKSPTYSKPTDRRTNPGRMLAASF || ||||||||||    |||||:|||||||||||||||||||||||||||||||||||| a073TCMSYKIRVSDGICGVFPPMPSEXRNQRASACFKSSIKSPTYSKPTDRRTNPGRMLAASF        10        20        30        40        50        60 60        70        80        90       100       110 m073.pepSSGCILPCVVVHGWVMVERTSPRLAVREKSSTPSTTFHAASXSATSKPMTMPPPFCCLRI||||||||||||||||||||||||||||||||||||||||: |||||||||||||||||| a073SSGCILPCVVVHGWVMVERTSPRLAVREKSSTPSTTFHAAAWSATSKPMTMPPPFCCLRI        70        80        90       100       110       120120       129 m073.pep SAAXGWSDNPVX |:||||| |||| a073 SSAXGWSGNPVX       130Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 073 shows 87.0% identity over a 131 aa overlap with a predicted ORF(ORF 073.ng) from N. gonorrhoeae:

m073/g073         10           20        30        40        50 m073.pepMCMPYKIRVSDGICC---PMPSETRNQRASACFKSSIKSPTYSKPTDRRTNPGRMLAASF||||| ||||||||   ||||||||||||||||||||||||||||||||:|||: |||| g073MCMPYAIRVSDGICRIFPPMPSETRNQRASACFKSSIKSPTYSKPTDRRTSPGRIPAASF        10        20        30        40        50        60 60        70        80        90       100       110 m073.pepSSGCILPCVVVHGWVMVERTSPRLAVREKSSTPSTTFHAASXSATSKPMTMPPPFCCLRI||||||||||||| ||||||||||||||||||   |||||: |||||||||||||||||| g073SSGCILPCVVVHGLVMVERTSPRLAVREKSST---TFHAAAWSATSKPMTMPPPFCCLRI        70        80        90          100       110 120      129m073.pep SAAXGWSDNPVX |:| ||| |||| g073 SSACGWSGNPVX 120The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 235>:

g075.seq 1 ATGCCGCCTT ACTTCATCAC CCTCTTAACG ATGGAAAATA CAAAAAGCGC 51GGCGAAAACG CCCACTACAA TCCAACCGGC TTCCATACCG TCCGCTTTTG 101 CGGCTTCCAAAGCGTTTTTT GCCGTTTCGG GCAACGCTGC GTTTGCCTGT 151 GCCGCCAAAG CCAGCGGGGCGGCTGTTACA ACAGCCAGTT TTGCGCCGTA 201 TTTACGGCAG GTGTTAATAA ATTTCATGATATTTTCCTTT ACGAAATTTT 251 TAAAAAAATG TGTTTGCGGG CTTTGTGAAG GTTTTAGAGACCGCCTGCCG 301 GGCCTCTTAA ACTTAATCTT CTTTTTCGTA GAATCCGAAA ATTACAAATT351 CCCCGCCTAT CTCTTCCAAT GCCGAGCTAA AAGCGTCTTC ATAGCTGTCA 401TATTTACCGG CTGAThis corresponds to the amino acid sequence <SEQ ID 236; ORF 075.ng>:

g075.pep 1 MPPYFITLLT MENTKSAAKT PTTIQPASIP SAFAASKAFF AVSGNAAFAC 51AAKASGAAVT TASFAPYLRQ VLINFMIFSF TKFLKKCVCG LCEGFRDRLP 101 GLLNLIFFFVESENYKFPAY LFQCRAKSVF IAVIFTG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 237>:

m075.seq 1 ATGCCGTCTT ACTTCATCAC TCTCTTAACG ATGGAAAATA CAAAAAGCGC 51GGCGAAAATG CCCACTACAA TCCAACCGGC TTCCATACCG TCCGCTTTTG 101 CGGCTTCCAAAGCGTTTTTT GCCGTATCGG GCAACGTTGC ATTTGCATGT 151 GCGGCCAAAG CCAGGGGAGCAGCTGTTACA ACAGCCAGTT TTGCGCCGTA 201 TTTACGGCAG GTGTTAATAA ATTTCATGATATTTTCCTTC AAAAAGTGTT 251 TGGCGGTAAT GGATGGAGCG TTTTTCAGAC GACCGCCGAACATCCGAAAA 301 TCAGTCTTTC AAAAATCCGA ATACGACAAA TTCGTATTGG TTGCCGATTT351 CTTCCAAACC TGCGTTAATC GCTTCTTCGA AGTCGTAGAA ATAATCGGCA 401TTGGTGATTA AThis corresponds to the amino acid sequence <SEQ ID 238; ORF 075>:

m075.pep 1 MPSYFITLLT MENTKSAAKM PTTIQPASIP SAFAASKAFF AVSGNVAFAC 51AAKARGAAVT TASFAPYLRQ VLINFMIFSF KKCLAVMDGA FFRRPPNIRK 101 SVFQKSEYDKFVLVADFFQT CVNRFFEVVE IIGIGD*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 075 shows 65.7% identity over a 137 aa overlap with a predicted ORF(ORF 075.ng) from N. gonorrhoeae:

m075/g075         10        20        30        40        50        60m075.pep MPSYFITLLTMENTKSAAKMPTTIQPASIPSAFAASKAFFAVSGNVAFACAAKARGAAVT|| |||||||||||||||| |||||||||||||||||||||||||:|||||||| ||||| g075MPPYFITLLTMENTKSAAKTPTTIQPASIPSAFAASKAFFAVSGNAAFACAAKASGAAVT        10        20        30        40        50        60        70        80            90       100        110 m075.pepTASFAPYLRQVLINFMIFSF----KKCLAVMDGAFFRRPPNIRKSVFQKSEYDKFVLVAD||||||||||||||||||||    |||:  :  :|  | |:: : :|   | ::: : | g075TASFAPYLRQVLINFMIFSFTKFLKKCVCGLCEGFRDRLPGLLNLIFFFVESENYKFPAY        70        80        90       100       110       120 120       130 m075.pep FFQTCVNRFFEVVEIIGIGDX :||  ::  | :| : | g075LFQCRAKSVFIAVIFTGX        130The following partial DNA sequence was identified in N. meningitidis<SEQ ID 239>:

a075.seq 1 ATGCCGTCTT ACTTCATCAC TCTCTTAACG ATGGAAAAGA CAAAAAGCGC 51GGCGAAAACG CCCACTACAA TCCAACCGGC TTCCATACCG TCCGCTTTTG 101 CGGCTTCCAAAGCGTTTTTT GCTGTATCGG GCAACGTTGC ATTTGCATGT 151 GCGGCCAAAG CCAGGGGAGCAGCTGTTACA ACAGCCAGTT TTGCGCCGTA 201 TTTACGGCAG GTGTTAATAA ATTTCATGATATTTTCCTTC AAAAAGTGTT 251 TGGCGGTAAT GGATGGAGCG TTTTTCAGAC GACCGCCGAACATCCGAAAA 301 TCAGTCTTTC AAAAATCCGA ATACGACAAA TTCGTATTGG TTGCCGATTT351 CTTCCAAACC TGCGTTAATC GCTTCTTCGA AGTCGTAGAA ATAATCGGCA 401TTGGTGATTA AThis corresponds to the amino acid sequence <SEQ ID 240; ORF 075.a>:

a075.pep 1 MPSYFITLLT MEKTKSAAKT PTTIQPASIP SAFAASKAFF AVSGNVAFAC 51AAKARGAAVT TASFAPYLRQ VLINFMIFSF KKCLAVMDGA FFRRPPNIRK 101 SVFQKSEYDKFVLVADFFQT CVNRFFEVVE IIGIGD* m075/a075 98.5% identity over a 136 aaoverlap         10        20        30        40        50        60m075.pep MPSYFITLLTMENTKSAAKMPTTIQPASIPSAFAASKAFFAVSGNVAFACAAKARGAAVT||||||||||||:|||||| |||||||||||||||||||||||||||||||||||||||| a075MPSYFITLLTMEKTKSAAKTPTTIQPASIPSAFAASKAFFAVSGNVAFACAAKARGAAVT        10        20        30        40        50        60        70        80        90       100       110       120 m075.pepTASFAPYLRQVLINFMIFSFKKCLAVMDGAFFRRPPNIRKSVFQKSEYDKFVLVADFFQT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a075TASFAPYLRQVLINFMIFSFKKCLAVMDGAFFRRPPNIRKSVFQKSEYDKFVLVADFFQT        70        80        90       100       110       120        130m075.pep CVNRFFEVVEIIGIGDX ||||||||||||||||| a075 CVNRFFEVVEIIGIGDX       130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 241>:

g080.seq 1 ATGTGGGATA ATGCCGAAGC GATGGAACGG CTGACGCGCT GGCTGCTTGT 51CATGATGGCG ATGCTGCTTG CTGCGTCCGG GCTGGTTTGG TTTTACAATT 101 CGAATCATCTGCCCGTCAAG CAGGTGTCGC TGAAGGGCAA CCTGGTTTAT 151 TCCGATAAGA AGGCATTGGGCAGTTTGGCG AAAGAATACA TCCATGGGAA 201 TATTTTGAGG ACGGACATCA ATGGCGCACAGGAAGCCTAC CGCCGGTATC 251 CGTGGATTGC GTCGGTCATG GTGCGCCGCC GTTTTCCCGATACGGTTGAG 301 GTCGTCCTGA CCGAGCGCAA GCCGGTTGCA CGTTGGGGCG ACCATGCCTT351 GGTGGACGGC GAAGGCAATG TTTTTGAAGC CCGCTTGGAC AGACCCGGAA 401TGCCGGTATT CAGAGGCGCG GAAGGAACGT CTGCCGAAAT GCTCCGCCGT 451 TATGACGAATTTTCGACTGT TTTGGCAAAA CAGGGTTTGG GCATCAAAGA 501 GATGACCTAT ACGGCACGTTCGGCGTGGAA TGTCGTTTTG GACAACGGCA 551 TCACCGTCAG GCTCGGACGG GAAAAcgaGATGAAACGCCT CCgGCTTTTT 601 ACcgAAGCGT GGCAGCATCT gttgcGTAAG AATAAAAATCGGTTATCCTA 651 TGTGGATATG Aggtataagg acggatttTC agtcccccat gctCCCGACG701 GTTTACCCGA AAAAGAATcc gAAGAATatt gggaacaggt ttgggacata 751ttacggcctg gcgtcggaaa cggttcgacg caaatttcaa tcagttatAA 801 GGGCAGacgaacaatggaac AGcagtaaThis corresponds to the amino acid sequence <SEQ ID 242; ORF 080.ng>:

g080.pep 1 MWDNAEAMER LTRWLLVMMA MLLAASGLVW FYNSNHLPVK QVSLKGNLVY 51SDKKALGSLA KEYIHGNILR TDINGAQEAY RRYPWIASVM VRRRFPDTVE 101 VVLTERKPVARWGDHALVDG EGNVFEARLD RPGMPVFRGA EGTSAEMLRR 151 YDEFSTVLAK QGLGIKEMTYTARSAWNVVL DNGITVRLGR ENEMKRLRLF 201 TEAWQHLLRK NKNRLSYVDM RYKDGFSVPHAPDGLPEKES EEYWEQVWDI 251 LRPGVGNGST QISISYKGRR TMEQQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 243>:

m080.seq 1 ATGTGGGATA ATGCCGAAGC GATGGAACGG CTGACGCGCT GGCTGCTTGT 51CATGATGGCG ATGCTGCTTG CTGCGTCCGG GCTGGTTTGG TTTTACAATT 101 CGAATCATCTGCCCGTCAAG CAGGTGTCGC TGAAGGGCAA CCTGGTTTAT 151 TCCGATAAGA AGACATTGGGCAGTTTGGCG AAAGAATACA TCCATGGGAA 201 TATTTTGAGG ACGGACATCA ATGGCGCACAGGAGGCCTAC CGCCGGTATC 251 CGTGGATTGC GTCGGTCATG GTGCGCCGCC GTTTTCCCGACACGGTTGAG 301 GTCGTCCTGA CCGAGCGCAA GCCGGTCGCG CGTTGGGGCG ACCATGCCTT351 GGTGGACGGC GAAGGCAATG TTTTTGAAGC CCGCTTGGAC AGACCCGGAA 401TGCCGGTATT CAGAGGCGCG GAAGGAACGT CTGCCGAAAT GCTCCGCCGT 451 TATGACGAATTTTCGACTGT TTTGGCAAAA CAGGGTTTGG GCATCAAAGA 501 GATGACCTAT ACGGCACGTTCGGCGTGGAT TGTCGTTTTG GACAACGGCA 551 TCACCGTCAG GCTCGGACGG GAAAACGAGATGAAACGCCT CCGGCTTTTT 601 ACCGAAGCGT GGCAGCATCT GTTGCGTAAA AATAAAAATCGGTTATCCTA 651 TGTGGATATG AGGTATAAGG ACGGATTTTC AGTCCGCTAT GCTTCCGACG701 GTTTACCCGA AAAAGAATCC GAAGAATAGThis corresponds to the amino acid sequence <SEQ ID 2441; ORF 080>:

m080.pep 1 MWDNAEAMER LTRWLLVMMA MLLAASGLVW FYNSNHLPVK QVSLKGNLVY 51SDKKTLGSLA KEYIHGNILR TDINGAQEAY RRYPWIASVM VRRRFPDTVE 101 VVLTERKPVARWGDHALVDG EGNVFEARLD RPGMPVFRGA EGTSAEMLRR 151 YDEFSTVLAK QGLGIKEMTYTARSAWIVVL DNGITVRLGR ENEMKRLRLF 201 TEAWQHLLRK NKNRLSYVDM RYKDGFSVRYASDGLPEKES EE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 080 shows 97.9% identity over a 242 aa overlap with a predicted ORF(ORF 080.ng) from N. gonorrhoeae:

m080/g080         10        20        30        40        50        60m080.pep MWDNAEAMERLTRWLLVMMAMLLAASGLVWFYNSNHLPVKQVSLKGNLVYSDKKTLGSLA||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| 080MWDNAEAMERLTRWLLVMMAMLLAASGLVWFYNSNHLPVKQVSLKGNLVYSDKKALGSLA        10        20        30        40        50        60        70        80        90       100       110       120 m080.pepKEYIHGNILRTDINGAQEAYRRYPWIASVMVRRRFPDTVEVVLTERKPVARWGDHALVDG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 080KEYIHGNILRTDINGAQEAYRRYPWIASVMVRRRFPDTVEVVLTERKPVARWGDHALVDG        70        80        90       100       110       120       130       140       150       160       170       180 m080.pepEGNVFEARLDRPGMPVFRGAEGTSAEMLRRYDEFSTVLAKQGLGIKEMTYTARSAWIVVL|||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||| 080EGNVFEARLDRPGMPVFRGAEGTSAEMLRRYDEFSTVLAKQGLGIKEMTYTARSAWNVVL       130       140       150       160       170       180       190       200       210       220       230       240 m080.pepDNGITVRLGRENEMKRLRLFTEAWQHLLRKNKNRLSYVDMRYKDGFSVRYASDGLPEKES|||||||||||||||||||||||||||||||||||||||||||||||| :| |||||||| 080DNGITVRLGRENEMKRLRLFTEAWQHLLRKNKNRLSYVDMRYKDGFSVPHAPDGLPEKES       190       200       210       220       230       240 m080.pepEEX || 080 EEYWEQVWDILRPGVGNGSTQISISYKGRRTMEQQX       250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 245>:

a080.seq 1 ATGTGGGATA ATGCCGAAGC GATGGAACGG CTGACGCGCT GGCTGCTTGT 51CATGATGGCG ATGCTGCTTG CTGCGTCCGG GCTGGTTTGG TTTTACAATT 101 CGAATCATCTGCCCGTCAAG CAGGTGTCGC TGAAGGGCAA CCTAGTTTAT 151 TCCGATAAGA AAGCATTGGGCAGTTTGGCG AAAGAATACA TCCATGGGAA 201 TATTTTGAGG ACGGACATCA ATGGCGCACAGGAGGCCTAC CGCCGGTATC 251 CGTGGATTGC GTCGGTCATG GTGCGCCGCC GTTTTCCCGACACGGTTGAG 301 GTCGTCCTGA CCGAGCGCAA GCCGGTCGCG CGTTGGGGCG ACCATGCCTT351 GGTGGACGGC GAAGGCAATG TTTTTGAAGC CCGTTTGGAC AGACCCGGAA 401TGCCGGTATT CAGAGGCGCG GAAGGAACGT CTGCCGAAAT GCTCCGCCGT 451 TATGACGAATTTTCGACTGT TTTGGCAAAA CAGGGTTTGG GCATCAAAGA 501 GATGACCTAT ACGGCACGTTCGGCGTGGAT TGTCGTTTTG GACAACGGCA 551 TCACCGTCAG GCTCGGACGG GAAAACGAGATGAAACGCCT CCGGCTTTTT 601 ACCGAAGCGT GGCAACATCT GTTGCGTAAA AATAAAAATCGGTTATCCTA 651 TGTGGATATG AGGTATAAGG ACGGATTTTC AGTCCGCTAT GCTCCCGACG701 GTTTACCCGA AAAAGAATCC GAAGAATAGThis corresponds to the amino acid sequence <SEQ ID 246; ORF 080.a>:

a080.pep 1 MWDNAEAMER LTRWLLVMMA MLLAASGLVW FYNSNHLPVK QVSLKGNLVY 51SDKKALGSLA KEYIHGNILR TDINGAQEAY RRYPWIASVM VRRRFPDTVE 101 VVLTERKPVARWGDHALVDG EGNVFEARLD RPGMPVFRGA EGTSAEMLRR 151 YDEFSTVLAK QGLGIKEMTYTARSAWIVVL DNGITVRLGR ENEMKRLRLF 201 TEAWQHLLRK NKNRLSYVDM RYKDGFSVRYAPDGLPEKES EE* m080/a080 99.2% identity over a 242 aa overlap        10        20        30        40        50        60 m080.pepMWDNAEAMERLTRWLLVMMAMLLAASGLVWFYNSNHLPVKQVSLKGNLVYSDKKTLGSLA||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| a080MWDNAEAMERLTRWLLVMMAMLLAASGLVWFYNSNHLPVKQVSLKGNLVYSDKKALGSLA        10        20        30        40        50        60        70        80        90       100       110       120 m080.pepKEYIHGNILRTDINGAQEAYRRYPWIASVMVRRRFPDTVEVVLTERKPVARWGDHALVDG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a080KEYIHGNILRTDINGAQEAYRRYPWIASVMVRRRFPDTVEVVLTERKPVARWGDHALVDG        70        80        90       100       110       120       130       140       150       160       170       180 m080.pepEGNVFEARLDRPGMPVFRGAEGTSAEMLRRYDEFSTVLAKQGLGIKEMTYTARSAWIVVL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a080EGNVFEARLDRPGMPVFRGAEGTSAEMLRRYDEFSTVLAKQGLGIKEMTYTARSAWIVVL       130       140       150       160       170       180       190       200       210       220       230       240 m080.pepDNGITVRLGRENEMKRLRLFTEAWQHLLRKNKNRLSYVDMRYKDGFSVRYASDGLPEKES||||||||||||||||||||||||||||||||||||||||||||||||||| |||||||| a080DNGITVRLGRENEMKRLRLFTEAWQHLLRKNKNRLSYVDMRYKDGFSVRYAPDGLPEKES       190       200       210       220       230       240 m080.pepEEX ||| a080 EEXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 247>:

g081.seq 1 ATGAAACCAC TGGACCTAAA TTTCATCTGC CAAGCCCTCA AGCTTCCGAT 51GCCGTCTGAA AACAAACCCG TGTCGCGCAT CGTAACCGAC AGCCGCGATA 101 TTCGGGAAGGCGATGTGTTT TTCGCATTGG CGGGCGGGCG GTTTGACGCG 151 CATGATTTTG TTGGAGGCGTATTGTCTGCG GGCGCGGCGG CGGTTGTGGT 201 TTCGCGCGAA GATTGCGCGG CTTTGGGCGGCGCGTTGAAA GTCGATGACA 251 CGCTTGCCGC GTTGCAAACG TTGGCGAAGG CGTGGCGCGATAATGTGAAC 301 CCGTTTGTGT TCGGCATTAC CGGTTCGGGC GGCAAGACGA CGGTGAAGGA351 GATGCTGGCT GCGGTATTGC GCCGCCGTTT CGGCGATGAT GCCGTTTCGG 401CGACGGCAGG CAACTTCAAC AACCACAtcg gaTTGCCGCT GACTTTATTG 451 AAATtaaAcgaAAAACACCG CTATGCCGTG ATTGAAATGG GCATGAACCA 501 TTTTGGcgaa ctggcggtTttaacgcaaaT CGCCAAACCC GATGCCGCTT 551 TGGtcaACAA CGCCCTGCGC GCCCATGTCGGATGCGGTTt cgacggagtg 601 GGCGATATTG CCAAAGcgaa aagcGAGATT TatgcagGcttATGTTCAGA 651 CGGCATGGCA CTGATTCCTC AAGAAGATGC CAATATGGCT GTCTTCAAAA701 CGGCAACGTT TAATTTGAAT ACGTGCACTT TCGGCGTCGA TAGCGGCGAT 751GTCCGCGCGG AAAATATCGT GCTGAAACCT TTGTCGTGCG AATTTGATTT 801 GGTGTGCGGCGACGAGCGCA CTGCCGTGGT GCTGCCTGTT CCCGGCCGCC 851 ACAATGTCCA CAACGCCGCCGCTGCCGCCG CGCTGGCTTT GGCTGCCGGT 901 TTGAGTTTGA ACGATGTGGC GGAAGGTTTGCAAGGCTTCA GCAACATCAA 951 AGGCCGTCTG AACGTCAAAG CCGGCATCAA GGGCGCAACCCTGATTGACG 1001 ATACTTATAA TGCGAATCCC GACAGTATGA AAGCCGCGGT TGACGTGTTG1051 GCGCGTATGC CTGCGCCGCG CATTTTCGTG ATGGGCGATA TGGGCGAACT 1101GGGCGAGGAc gaAGCCGCCG CCATGCACGC CGAagtcgGC GCGTACGCCC 1151 GCGACCAAGGCATCGAAGCG GCTTATTTTG TCGGCGACAA CAGCGTCGAA 1201 GCGGcggaAA AATTTGGCGCGGACGGTTTG TGGTTCGCCG CCAAAGACCC 1251 GTTGATTCAA GTGTTGAGCC ACGATTTGCCCGAACGCGCC ACCGTGTTGG 1301 TGAAAGGTTC GCGCTTTATG CAGAtggAAG AAGTGGTCGAGGCATTGGAG 1351 GATAAGTgaThis corresponds to the amino acid sequence <SEQ ID 248; ORF 081.ng>:

g081.pep 1 MKPLDLNFIC QALKLPMPSE NKPVSRIVTD SRDIREGDVF FALAGGRFDA 51HDFVGGVLSA GAAAVVVSRE DCAALGGALK VDDTLAALQT LAKAWRDNVN 101 PFVFGITGSGGKTTVKEMLA AVLRRRFGDD AVSATAGNFN NHIGLPLTLL 151 KLNEKHRYAV IEMGMNHFGELAVLTQIAKP DAALVNNALR AHVGCGFDGV 201 GDIAKAKSEI YAGLCSDGMA LIPQEDANMAVFKTATFNLN TCTFGVDSGD 251 VRAENIVLKP LSCEFDLVCG DERTAVVLPV PGRHNVHNAAAAAALALAAG 301 LSLNDVAEGL QGFSNIKGRL NVKAGIKGAT LIDDTYNANP DSMKAAVDVL351 ARMPAPRIFV MGDMGELGED EAAAMHAEVG AYARDQGIEA AYFVGDNSVE 401AAEKFGADGL WFAAKDPLIQ VLSHDLPERA TVLVKGSRFM QMEEVVEALE 451 DK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 249>:

m081.seq 1 ATGAAACCAC TGGACCTAAA TTTCATCTGC CAAGCCCTCA AGCTTCCGAT 51GCCGTCTGAA AGCAAACCCG TGTCGCGCAT CGTAACCGAC AGCCGCGACA 101 TCCGCGCGGGCGATGTGTTT TTCGCATTGG CGGGCGAGCG GTTTGACGCG 151 CATGATTTTG TTGAAGACGTATTGGCTGCT GGTGCGGCGG CGGTTGTGGT 201 TTCGCGCGAA GATTGTGCTG CAATGGATGGCGCGTTGAAA GTCGATGACA 251 CGCTTGCCGC ATTGCAAACG CTGGCAAAGG CGTGGCGTGAAAATGTGAAT 301 CCGTTTGTGT TCGGCATTAC CGGTTCGGGC GGCAAGACGA CGGTGAAGGA351 AATGCTGGCT GCGGTATTGC GCCgCCGTTT CGGCGATGAT GCCGTGTTGG 401CGACGGCAGG CAACTTCAAC AACCATATCG GATTGCCGCT GACTTTGTTG 451 AAGTTAAACGAAAAACACCG CTATGCCGTG ATTGAAATGG GCATGAACCA 501 TTTCGGCGAA CTGGCGGTTTTAACGCAmAT CGCCAAACCA AATGCCGCAT 551 TGGTCAACAA CGCCATGCGC GCCCATGTCGGCTGCGGTTT CGACGGAGTG 601 GGCGATATTG CCAAAGCGAA AAGCGAGATT TACCAAGGTTTATGTTCAGA 651 CGGCATTGCA CTGATTCCTC AAGAAGATGC CAATATGGCT GTCTTCAAAA701 CGGCAACGCT TAATTTGAAT ACGCGCACTT TCGGCATCGA TAGCGGCGAT 751GTTCACGCGG AAAATATTGT GCTGAAACCG TTGTCGTGCG AATTTGATTT 801 GGTGTGCGGCGATGAGCGCG CCGCCGTGGT GCTGCCTGTT CCCGGCCGCC 851 ACAATGTCCA CAACGCCGCCGCTGCCGCCG CGCTGGCTTT GGCTGCGGGT 901 TTGAGTTTGA ACGATGTGGC GGAAGGTTTGAAAGGCTTCA GCAATATCAA 951 AGGCCGTCTG AACGTCAAAT CCGGAATCAA GGGCGCAACCCTGATTGACG 1001 ATACTTATAA TGCGAACCCT GACAGCATGA AAGCTGCGAT TGACGTGTTG1051 GCGCGTATGC CTGCGCCGCG TATTTTCGTG ATGGGCGATA TGGGCGAACT 1101GGGCGAACTG GGCGAGGACG AAGCCGCCGC TATGCACGCC GAAGTCGGCG 1151 CGTATGCCCGCGACCAAGGC ATCGAAGCGG CTTATTTTGT CGGCGACAAC 1201 AGCGTCGAAG CGGCGGAAAAATTTGGCGCG GACGGTTTGT GGTTCGCCGC 1251 CAAAGACCCG TTGATTCAAG TGTTGCGCCACGATTTGCCC GAACGCGCCA 1301 CCGTGTTGGT GAAAGGTTCG CGCTTTATGC AGATGGAAGAAGTGGTCGAG 1351 GCATTGGAGG ATAAGTGAThis corresponds to the amino acid sequence <SEQ ID 250; ORF 081>:

m081.pep 1 MKPLDLNFIC QALKLPMPSE SKPVSRIVTD SRDIRAGDVF FALAGERFDA 51HDFVEDVLAA GAAAVVVSRE DCAAMDGALK VDDTLAALQT LAKAWRENVN 101 PFVFGITGSGGKTTVKEMLA AVLRRRFGDD AVLATAGNFN NHIGLPLTLL 151 KLNEKHRYAV IEMGMNHFGELAVLTXIAKP NAALVNNAMR AHVGCGFDGV 201 GDIAKAKSEI YQGLCSDGIA LIPQEDANMAVFKTATLNLN TRTFGIDSGD 251 VHAENIVLKP LSCEFDLVCG DERAAVVLPV PGRHNVHNAAAAAALALAAG 301 LSLNDVAEGL KGFSNIKGRL NVKSGIKGAT LIDDTYNANP DSMKAAIDVL351 ARMPAPRIFV MGDMGELGEL GEDEAAAMHA EVGAYARDQG IEAAYFVGDN 401SVEAAEKFGA DGLWFAAKDP LIQVLRHDLP ERATVLVKGS RFMQMEEVVE 451 ALEDK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 081 shows 94.1% identity over a 455 aa overlap with a predicted ORF(ORF 081.ng) from N. gonorrhoeae:

m081/g081         10        20        30        40        50        60m081.pep MKPLDLNFICQALKLPMPSESKPVSRIVTDSRDIRAGDVFFALAGERFDAHDFVEDVLAA||||||||||||||||||||:|||||||||||||| ||||||||| ||||||||  ||:| g081MKPLDLNFICQALKLPMPSENKPVSRIVTDSRDIREGDVFFALAGGRFDAHDFVGGVLSA        10        20        30        40        50        60        70        80        90       100       110       120 m081.pepGAAAVVVSREDCAAMDGALKVDDTLAALQTLAKAWRENVNPFVFGITGSGGKTTVKEMLA||||||||||||||: ||||||||||||||||||||:||||||||||||||||||||||| g081GAAAVVVSREDCAALGGALKVDDTLAALQTLAKAWRDNVNPFVFGITGSGGKTTVKEMLA        70        80        90       100       110       120       130       140       150       160       170       180 m081.pepAVLRRRFGDDAVLATAGNFNNHIGLPLTLLKLNEKHRYAVIEMGMNHFGELAVLTXIAKP|||||||||||| |||||||||||||||||||||||||||||||||||||||||| |||| g081AVLRRRFGDDAVSATAGNFNNHIGLPLTLLKLNEKHRYAVIEMGMNHFGELAVLTQIAKP       130       140       150       160       170       180       190       200       210       220       230       240 m081.pepNAALVNNAMRAHVGCGFDGVGDIAKAKSEIYQGLCSDGIALIPQEDANMAVFKTATLNLN:|||||||:|||||||||||||||||||||| ||||||:|||||||||||||||||:||| g081DAALVNNALRAHVGCGFDGVGDIAKAKSEIYAGLCSDGMALIPQEDANMAVFKTATFNLN       190       200       210       220       230       240       250       260       270       280       290       300 m081.pepTRTFGIDSGDVHAENIVLKPLSCEFDLVCGDERAAVVLPVPGRHNVHNAAAAAALALAAG| |||:|||||:|||||||||||||||||||||:|||||||||||||||||||||||||| g081TCTFGVDSGDVRAENIVLKPLSCEFDLVCGDERTAVVLPVPGRHNVHNAAAAAALALAAG       250       260       270       280       290       300       310       320       330       340       350       360 m081.pepLSLNDVAEGLKGFSNIKGRLNVKSGIKGATLIDDTYNANPDSMKAAIDVLARMPAPRIFV||||||||||:||||||||||||:||||||||||||||||||||||:||||||||||||| g081LSLNDVAEGLQGFSNIKGRLNVKAGIKGATLIDDTYNANPDSMKAAVDVLARMPAPRIFV       310       320       330       340       350       360       370       380       390       400       410       420 m081.pepMGDMGELGELGEDEAAAMHAEVGAYARDQGIEAAYFVGDNSVEAAEKFGADGLWFAAKDP|||||||||   |||||||||||||||||||||||||||||||||||||||||||||||| g081MGDMGELGE---DEAAAMHAEVGAYARDQGIEAAYFVGDNSVEAAEKFGADGLWFAAKDP          370       380       390       400       410       430       440       450 m081.pepLIQVLRHDLPERATVLVKGSRFMQMEEVVEALEDKX||||| |||||||||||||||||||||||||||||| g081LIQVLSHDLPERATVLVKGSRFMQMEEVVEALEDKX 420       430       440       450The following partial DNA sequence was identified in N. meningitidis<SEQ ID 251>:

a081.seq 1 ATGAAACCAC TGGACCTAAA TTTCATCTGC CAAGCCCTCA AGCTTCCGAT 51GCCGTCTGAA AGCAAACCCG TGTCGCGCAT CGTAACCGAC AGCCGCGACA 101 TCCGCGCGGGCGATGTGTTT TTCGCATTGG CGGGCGGGCG GTTTGATGCG 151 CATGATTTTG TTGAAGACGTATTGGCTGCG GGTGCGGCGG CGGTTGTGGT 201 TTCGCGCGAA GATTGCGTTG CAATGGATGGCGCGTTGAAA GTCGATGACA 251 CGCTTACCGC GTTGCAAATG TTGGCGAAGG CGTGGCGCGAGAATGTGAAC 301 CCGTTTGTGT TCGGTATTAC CGGCTCGGGC GGCAAGACGA CGGTGAAGGA351 AATGTTGGCT GCGGTATTGC GCCGCCGTTT CGGCGATAAT GCCGTTTTGG 401CGACGGCAGG CAACTTCAAC AACCACATCG GATTGCCGTT GACTTTGTTG 451 AAATTAAACGAAAAACACCG CTATGCCGTG ATTGAAATGG GTATGAACCA 501 TTTTGGCGAA CTGGCGGTTTTGACACAAAT CGCCAAACCC GATGCCGCAT 551 TGGTCAACAA CGCCATGCGC GCCCATGTCGGCTGCGGTTT CGACGGAGTG 601 GGCGATATTG CCAAAGCGAA AAGCGAGATT TATCAAGGCTTATGTTCAGA 651 CGGCATGGCG CTGATTCCTC AAGAAGATGC CAATATGGCT GTCTTCAAAA701 CGGCAACGCT TAATTTGAAT ACGCGCACTT TCGGCATCGA TAGCGGCGAT 751GTCCACGCGG AAAATATCGT GCTGAAACCG TTGTCGTGCG AATTTGATTT 801 GGTGTGCGGCAACGAGTGCG CAGCCGTGGT TCTGCCCGTT CCCGGCCGCC 851 ACAATGTCCA CAACGCCGCCGCCGCCGCCG CGCTGTCTTT GGCTGCAGGT 901 TTGAGTTTGA ACGATGTGGC GGAAGGTTTGAAAGGCTTCA GCAATATCAA 951 AGGCCGTCTG AACGTCAAAT CCGGAATCAA GGGCGCAACCCTGATTGACG 1001 ATACTTATAA TGCGAACCCT GACAGCATGA AAGCTGCGGT TGACGTGTTG1051 GCGCGTATGC CTGCGCCGCG TATTTTCGTG ATGGGCGATA TGGGCGAACT 1101GGGTGAGGAC GAAGCCGCCG CCATGCACGC CGAAGTCGGC GCGTACGCCC 1151 GCGACCAAGGCATCGAAGCG GCTTATTTTG TCGGCGACAA CAGCGTCGAA 1201 GCGGCGGAAA AATTTGGCGCGGACGGTTTG TGGTTCGCCG CCAAAGACCC 1251 GTTGATTCAA GTGTTGCGCC ACGATTTGCCCGAACGCGCC ACCGTGTTGG 1301 TGAAAGGTTC GCGCTTTATG CAGATGGAAG AAGTGGTCGAGGCATTGGAG 1351 GATAAGTGAThis corresponds to the amino acid sequence <SEQ ID 252; ORF 081.a>:

a081.pep 1 MKPLDLNFIC QALKLPMPSE SKPVSRIVTD SRDIRAGDVF FALAGGRFDA 51HDFVEDVLAA GAAAVVVSRE DCVAMDGALK VDDTLTALQM LAKAWRENVN 101 PFVFGITGSGGKTTVKEMLA AVLRRRFGDN AVLATAGNFN NHIGLPLTLL 151 KLNEKHRYAV IEMGMNHFGELAVLTQIAKP DAALVNNAMR AHVGCGFDGV 201 GDIAKAKSEI YQGLCSDGMA LIPQEDANMAVFKTATLNLN TRTFGIDSGD 251 VHAENIVLKP LSCEFDLVCG NECAAVVLPV PGRHNVHNAAAAAALSLAAG 301 LSLNDVAEGL KGFSNIKGRL NVKSGIKGAT LIDDTYNANP DSMKAAVDVL351 ARMPAPRIFV MGDMGELGED EAAAMHAEVG AYARDQGIEA AYFVGDNSVE 401AAEKFGADGL WFAAKDPLIQ VLRHDLPERA TVLVKGSRFM QMEEVVEALE 451 DK* m081/a08196.7% identity over a 455 aa overlap        10        20        30        40        50        60 m081.pepMKPLDLNFICQALKLPMPSESKPVSRIVTDSRDIRAGDVFFALAGERFDAHDFVEDVLAA||||||||||||||||||||||||||||||||||||||||||||| |||||||||||||| a081MKPLDLNFICQALKLPMPSESKPVSRIVTDSRDIRAGDVFFALAGGRFDAHDFVEDVLAA        10        20        30        40        50        60        70        80        90       100       110       120 m081.pepGAAAVVVSREDCAAMDGALKVDDTLAALQTLAKAWRENVNPFVFGITGSGGKTTVKEMLA||||||||||||:||||||||||||:||| |||||||||||||||||||||||||||||| a081GAAAVVVSREDCVAMDGALKVDDTLTALQMLAKAWRENVNPFVFGITGSGGKTTVKEMLA        70        80        90       100       110       120       130       140       150       160       170       180 m081.pepAVLRRRFGDDAVLATAGNFNNHIGLPLTLLKLNEKHRYAVIEMGMNHFGELAVLTXIAKP|||||||||:||||||||||||||||||||||||||||||||||||||||||||| |||| a081AVLRRRFGDNAVLATAGNFNNHIGLPLTLLKLNEKHRYAVIEMGMNHFGELAVLTQIAKP       130       140       150       160       170       180       190       200       210       220       230       240 m081.pepNAALVNNAMRAHVGCGFDGVGDIAKAKSEIYQGLCSDGIALIPQEDANMAVFKTATLNLN:|||||||||||||||||||||||||||||||||||||:||||||||||||||||||||| a081DAALVNNAMRAHVGCGFDGVGDIAKAKSEIYQGLCSDGMALIPQEDANMAVFKTATLNLN       190       200       210       220       230       240       250       260       270       280       290       300 m081.pepTRTFGIDSGDVHAENIVLKPLSCEFDLVCGDERAAVVLPVPGRHNVHNAAAAAALALAAG||||||||||||||||||||||||||||||:| ||||||||||||||||||||||:|||| a081TRTFGIDSGDVHAENIVLKPLSCEFDLVCGNECAAVVLPVPGRHNVHNAAAAAALSLAAG       250       260       270       280       290       300       310       320       330       340       350       360 m081.pepLSLNDVAEGLKGFSNIKGRLNVKSGIKGATLIDDTYNANPDSMKAAIDVLARMPAPRIFV||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||| a081LSLNDVAEGLKGFSNIKGRLNVKSGIKGATLIDDTYNANPDSMKAAVDVLARMPAPRIFV       310       320       330       340       350       360       370       380       390       400       410       420 m081.pepMGDMGELGELGEDEAAAMHAEVGAYARDQGIEAAYFVGDNSVEAAEKFGADGLWFAAKDP|||||||||   |||||||||||||||||||||||||||||||||||||||||||||||| a081MGDMGELGE---DEAAAMHAEVGAYARDQGIEAAYFVGDNSVEAAEKFGADGLWFAAKDP          370       380       390       400       410       430       440       450 m081.pepLIQVLRHDLPERATVLVKGSRFMQMEEVVEALEDKX|||||||||||||||||||||||||||||||||||| a081LIQVLRHDLPERATVLVKGSRFMQMEEVVEALEDKX 420       430       440       450The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 253>:

g082.seq 1 aTGTGGTTGT TGAAGTTGCC TGCCGTCGCC GAAACGGCAT CATCGCCGAA 51ACGGCGGCGC AATACCGCAG CCAGCATCTC CTTCACCGTC GTCTTGCCGC 101 CCGAACCGGTAATGCCGAAC ACAAACGGGT TCACATTATC GCGCCACGCC 151 TTCGCCAACG TTTGCAACGCGGCAAGCGTG TCATCGACTT TCAACGCGCC 201 GCCCAAAGCC GCGCAATCTT CGCGCGAAACCACAACCGCC GCCGCGCCCG 251 CAGACAATAC GCCTCCAACA AAATCATGCG CGTCAAACCGCCCGCCCGCC 301 AATGCGAAAA ACACATCGCC TTCCCGAATA TCGCGGCTGT CGGTTACGAT351 GCGCGACACG GGTTTGTTTT CAGACGGCAT CGGAAGCTTG AGGGCTTGGC 401AGATGAAATT TAGGTCCAGT GGTTTCATAT TTGCTTTCGT TAATATTCGG 451 GCGGCGGACACATCGGTAGC GGCTGATTTT TTTATCGCCT GTTTTGCTGT 501 GGTAAAACAC AGATTATTTTCCCATTCTCA TTCGGCATTT TTTCTGTACG 551 TATCATTTTT TAGACGTATT TTTAGCCGATTTGCCTTTTC CCGCATACCA 601 CGGCGCGGGG TCGTCGGACT GTCTGTCGAT AAAGGCAAGGTTATTGCCTT 651 CGCCCGGCAC ATCGGGGACA TTCCCCCAAA AATCATAGCC GTCATCGGGC701 AACTCGTCGG TTTCGATACC CGTCCAACTG CCGAATCCGC GTAAThis corresponds to the amino acid sequence <SEQ ID 254; ORF 082.ng>:

g082.pep 1 MWLLKLPAVA ETASSPKRRR NTAASISFTV VLPPEPVMPN TNGFTLSRHA 51FANVCNAASV SSTFNAPPKA AQSSRETTTA AAPADNTPPT KSCASNRPPA 101 NAKNTSPSRISRLSVTMRDT GLFSDGIGSL RAWQMKFRSS GFIFAFVNIR 151 AADTSVAADF FIACFAVVKHRLFSHSHSAF FLYVSFFRRI FSRFAFSRIP 201 RRGVVGLSVD KGKVIAFARH IGDIPPKIIAVIGQLVGFDT RPTAESA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 255>:

m082.seq 1 ATGnnGTTGT TGAAGTTGCC TGCCGTCGCC AACACGGCAT CATCGCCGAA 51ACGGcGGCGC AATACCGCAG CCAGCATTTC CTTCACCGTC GTCTTGCCGC 101 CCGAACCGGTAATGCCGAAC ACAAACGGAT TCACATTTTC ACGCCACGCC 151 TTTGCCAGCG TTTGCAATGCGGCAAGCGTG TCATCGACTT TCAACGCGCC 201 ATCCATTGCA GCACAATCTT CGCGCGAAACCACAACCGCC GCCGCACCAG 251 CAGCCAATAC GTCTTCAACA AAATCATGCG CGTCAAACCGCTCGCCCGCC 301 AATGCGAAAA ACACATCGCC CGCGCGGATG TCGCGGCTGT CGGTTACGAT351 GCGCGACACG GGTTTGCTTT CAGACGGCAT CGGAAGCTTG AGGGCTTGGC 401AGATGAAATT TAGGTCCAGT GGTTTCATAT TTACTTTCGT TAATATTCGG 451 GCGGCGGACACATCGGTAGC GGCTGATTTT TTTATCGCCT GTTTTGCTGT 501 GGTAAAACAC AGATTATTTTCCCATTCTCA TTCGGsATTT TTTCTGTACG 551 TATCATTTTT TAGACGTATT TTTAGTCGATTTGCCTTTTC CCGCATACCA 601 CGGCGCGGGG TCGTCGGGCA GTCCGTCGAT AAAGGCAAGGTTATTGCCTT 651 CGCCCTGCAC ATCGGGAACA TTCCCCCAAA AATCATAGCC GTCATCGGGC701 AACTCGTCGG TTTCGATACC CGTCCAACTG CCGAATCCGC GTAAThis corresponds to the amino acid sequence <SEQ ID 256; ORF 082>:

m082.pep 1 MXLLKLPAVA NTASSPKRRR NTAASISFTV VLPPEPVMPN TNGFTFSRHA 51FASVCNAASV SSTFNAPSIA AQSSRETTTA AAPAANTSST KSCASNRSPA 101 NAKNTSPARMSRLSVTMRDT GLLSDGIGSL RAWQMKFRSS GFIFTFVNIR 151 AADTSVAADF FIACFAVVKHRLFSHSHSXF FLYVSFFRRI FSRFAFSRIP 201 RRGVVGQSVD KGKVIAFALH IGNIPPKIIAVIGQLVGFDT RPTAESA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 082 shows 92.7% identity over a 247 aa overlap with a predicted ORF(ORF 082.ng) from N. gonorrhoeae:

m082/g082         10        20        30        40        50        60m082.pep MXLLKLPAVANTASSPKRRRNTAASISFTVVLPPEPVMPNTNGFTFSRHAFASVCNAASV| ||||||||:||||||||||||||||||||||||||||||||||:||||||:||||||| g082MWLLKLPAVAETASSPKRRRNTAASISFTVVLPPEPVMPNTNGFTLSRHAFANVCNAASV        10        20        30        40        50        60        70        80        90       100       110       120 m082.pepSSTFNAPSIAAQSSRETTTAAAPAANTSSTKSCASNRSPANAKNTSPARMSRLSVTMRDT|||||||  ||||||||||||||| ||  |||||||| |||||||||:|:|||||||||| g082SSTFNAPPKAAQSSRETTTAAAPADNTPPTKSCASNRPPANAKNTSPSRISRLSVTMRDT        70        80        90       100       110       120       130       140       150       160       170       180 m082.pepGLLSDGIGSLRAWQMKFRSSGFIFTFVNIRAADTSVAADFFIACFAVVKHRLFSHSHSXF||:|||||||||||||||||||||:||||||||||||||||||||||||||||||||| | g082GLFSDGIGSLRAWQMKFRSSGFIFAFVNIRAADTSVAADFFIACFAVVKHRLFSHSHSAF       130       140       150       160       170       180       190       200       210       220       230       240 m082.pepFLYVSFFRRIFSRFAFSRIPRRGVVGQSVDKGKVIAFALHIGNIPPKIIAVIGQLVGFDT|||||||||||||||||||||||||| ||||||||||| |||:||||||||||||||||| g082FLYVSFFRRIFSRFAFSRIPRRGVVGLSVDKGKVIAFARHIGDIPPKIIAVIGQLVGFDT       190       200       210       220       230       240 m082.pepRPTAESAX |||||||| g082 RPTAESAXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 257>:

a082.seq 1 ATGTGGTTGT TGAAGTTGCC TGCCGTCGCC AAAACGGCAT TATCGCCGAA 51ACGGCGGCGC AATACCGCAG CCAACATTTC CTTCACCGTC GTCTTGCCGC 101 CCGAGCCGGTAATACCGAAC ACAAACGGGT TCACATTCTC GCGCCACGCC 151 TTCGCCAACA TTTGCAACGCGGTAAGCGTG TCATCGACTT TCAACGCGCC 201 ATCCATTGCA ACGCAATCTT CGCGCGAAACCACAACCGCC GCCGCACCCG 251 CAGCCAATAC GTCTTCAACA AAATCATGCG CATCAAACCGCCCGCCCGCC 301 AATGCGAAAA ACACATCGCC CGCGCGGATG TCGCGGCTGT CGGTTACGAT351 GCGCGACACG GGTTTGCTTT CAGACGGCAT CGGAAGCTTG AGGGCTTGGC 401AGATGAAATT TAGGTCCAGT GGTTTCATAT TTACTTTCGT TAATATTCGG 451 GCGGCGGACACATCGGTAGC GGCTGATTTT TTTATCGCCT GTTTTGCTGT 501 GGTAAAACAC AGATTATTTTCCCATTCTCA TTCGGCATTT TTTCTGTACG 551 TATCATTTTT TAGACGTATT TTTAGTCGATTTGCCTTTTC CCGCATACCA 601 CGGCGCGGGG TCGTCGGGCA GTCCGTCGAT AAAGGCAAGGTTATTGCCTT 651 CGCCCTGCAC ATCGGGAACA TTCCCCCAAA AATCATAGCC GTCATCGGGC701 AACTCGTCGG TTTCGATACC CGTCCAACTG CCGAATCCGC GTAAThis corresponds to the amino acid sequence <SEQ ID 258; ORF 082.a>:

a082.pep 1 MWLLKLPAVA KTALSPKRRR NTAANISFTV VLPPEPVIPN TNGFTFSRHA 51FANICNAVSV SSTFNAPSIA TQSSRETTTA AAPAANTSST KSCASNRPPA 101 NAKNTSPARMSRLSVTMRDT GLLSDGIGSL RAWQMKFRSS GFIFTFVNIR 151 AADTSVAADF FIACFAVVKHRLFSHSHSAF FLYVSFFRRI FSRFAFSRIP 201 RRGVVGQSVD KGKVIAFALH IGNIPPKIIAVIGQLVGFDT RPTAESA* m082/a082 95.5% identity over a 247 aa overlap        10        20        30        40        50        60 m082.pepMXLLKLPAVANTASSPKRRRNTAASISFTVVLPPEPVMPNTNGFTFSRHAFASVCNAASV| ||||||||:|| ||||||||||:||||||||||||:||||||||||||||::|||:|| a082MWLLKLPAVAKTALSPKRRRNTAANISFTVVLPPEPVIPNTNGFTFSRHAFANICNAVSV        10        20        30        40        50        60        70        80        90       100       110       120 m082.pepSSTFNAPSIAAQSSRETTTAAAPAANTSSTKSCASNRSPANAKNTSPARMSRLSVTMRDT||||||||||:|||||||||||||||||||||||||| |||||||||||||||||||||| a082SSTFNAPSIATQSSRETTTAAAPAANTSSTKSCASNRPPANAKNTSPARMSRLSVTMRDT        70        80        90       100       110       120       130       140       150       160       170       180 m082.pepGLLSDGIGSLRAWQMKFRSSGFIFTFVNIRAADTSVAADFFIACFAVVKHRLFSHSHSXF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| | a082GLLSDGIGSLRAWQMKFRSSGFIFTFVNIRAADTSVAADFFIACFAVVKHRLFSHSHSAF       130       140       150       160       170       180       190       200       210       220       230       240 m082.pepFLYVSFFRRIFSRFAFSRIPRRGVVGQSVDKGKVIAFALHIGNIPPKIIAVIGQLVGFDT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a082FLYVSFFRRIFSRFAFSRIPRRGVVGQSVDKGKVIAFALHIGNIPPKIIAVIGQLVGFDT       190       200       210       220       230       240 m082.pepRPTAESAX |||||||| a082 RPTAESAXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 259>:

g084.seq 1 ATGAAacaAT CCGcccgaat aAAAAATATG GATCAGACAT TAAAAAATAc 51attgggcatt tGCGCGcttt tagcctTTTG TTTTggcgcG gccaTCGCAT 101 CAGGTTATCACTTGGAATAT GAATACGGCT ACCGTTATTC TGCCGTGGGC 151 GCTTTGGCTT CGGTTGTATTTTTATTATTA TTGGCACGCG GCTTCCCGCG 201 CGTTTCTTCA GTTGTTTTAC TGATTTACGTCGGCACAACC GCCCTATATT 251 TGCCGGTCGG CTGGCTGTAT GGTGCGCCTT CTTATCAGATAGTCGGTTCG 301 ATATTGGAAA GCAATCCTGC CGAGGCGCGT GAATTTGTCG GCAATCTTCC351 CGGGTCGCTT TATTTTGTGC AGGCATTATT TTTCATTTTT GGCTTGACAG 401TTTGGAAATA TTGTGTATCT GTGGGGGTAT TTGCTGACGT AAAAAACTAT 451 AAACGTCGCAGCAAAATATG GCTGACCATA TTATTGACTT TGATTTTGTC 501 CTGCGCGGTG ATGGAGAAAATCGccggcga taaAGATTGG CGAGaacctg 551 atgccggcct gttgttgaat ATTTTcgacctgtattaCga cttggctttc 601 cgcgccggca cAATATGCCG CCAAGCGCGC CCAcattttggaagCagcaa 651 aaaaagcgtC AACATGGCAt atccgccaac ttgcgcccaa gTAtaaThis corresponds to the amino acid sequence <SEQ ID 260; ORF 084.ng>:

g084.pep 1 MKQSARIKNM DQTLKNTLGI CALLAFCFGA AIASGYHLEY EYGYRYSAVG 51ALASVVFLLL LARGFPRVSS VVLLIYVGTT ALYLPVGWLY GAPSYQIVGS 101 ILESNPAEAREFVGNLPGSL YFVQALFFIF GLTVWKYCVS VGVFADVKNY 151KRRSKIWLTI LLTLILSCAV MEKIAGDKDW REPDAGLLLN IFDLYYDLAF 201 RAGTICRQARPHFGSSKKSV NMAYPPTCAQ V*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 261>:

m084.seq 1 ATGAAACAAT CCGCCcGAAT AAAa.ATATG AATCAGACAT TACTTTATAC 51ATTGGGCATT TGCGCGCTTT TAACCTTTnn nnnnnnnnnn nnnnnnnnnn 101 nnnnnTATCACCCnGAATAT GAATACGGCT ACCGTTATTC TGCCGTGGGT 151 GCTTTGGCTT CGGTTGTATTTTTATTATTA TTGGCACGCG GTTTCCCGCG 201 CGTTTCTTCA GTTGTTTTAC TGATTTACGTCGGCACAACC GCCCTATATT 251 TGCCGGTCGG CTGGCTGTAT GGTGCGCCGT CTTATCAGATAGTCGGTTCG 301 ATATTGGAAA GCAATCCTGC CGAGGCGCGT GAATTTGTCG GCAATCTTCC351 CGGGTCGCTT TATTTTGTGC AGGCATTATT TTTCATTTTT GGCTTGACAG 401TTTGGAAATA TTGTGTATCG GGGGGGGTAT TTGCTGACGT AAAAAACTAT 451 AAACGCCGCAGCAAAATATG GCTGACTATA TTATTGACTT TGATTTTGTC 501 CTGCGCGGTG ATGGATAAAATCGCCAGCGA TAAAGATTTG CGAGAACCTG 551 ATGCCGGCCT GTTGTTGAAT ATTTTCGACCTGTATTACGA TTTGGCT.TC 601 CGCGCCGGCA CAATATGCCG CCAAGCGCGC CCACATTTTGGAAGCAGCAA 651 AAAAAGCGTC AACATGGCAT ATCCGTCATG TTGCGCCCAA GTATAAThis corresponds to the amino acid sequence <SEQ ID 262; ORF 084>:

m084.pep 1 MKQSARIKXM NQTLLYTLGI CALLTFXXXX XXXXXYHPEY EYGYRYSAVG 51ALASVVFLLL LARGFPRVSS VVLLIYVGTT ALYLPVGWLY GAPSYQIVGS 101 ILESNPAEAREFVGNLPGSL YFVQALFFIF GLTVWKYCVS GGVFADVKNY 151KRRSKIWLTI LLTLILSCAV MDKIASDKDL REPDAGLLLN IFDLYYDLAX 201 RAGTICRQARPHFGSSKKSV NMAYPSCCAQ V*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 084 shows 90.5% identity over a 231 aa overlap with a predicted ORF(ORF 084.ng) from N. gonorrhoeae:

m084/g084         10        20                 30        40        50m084.pep MKQSARIKXMNQTLLYTLGICALLTF---------YHPEYEYGYRYSAVGALASVVFLLL|||||||| |:|||  ||||||||:|         || |||||||||||||||||||||| g084MKQSARIKNMDQTLKNTLGICALLAFCFGAAIASGYHLEYEYGYRYSAVGALASVVFLLL        10        20        30        40        50        60       60        70        80        90       100       110 m084.pepLARGFPRVSSVVLLIYVGTTALYLPVGWLYGAPSYQIVGSILESNPAEAREFVGNLPGSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g084LARGFPRVSSVVLLIYVGTTALYLPVGWLYGAPSYQIVGSILESNPAEAREFVGNLPGSL        70        80        90       100       110       120      120       130       140       150       160       170 m084.pepYFVQALFFIFGLTVWKYCVSGGVFADVKNYKRRSKIWLTILLTLILSCAVMDKIASDKDL|||||||||||||||||||| ||||||||||||||||||||||||||||||:|||:||| g084YFVQALFFIFGLTVWKYCVSVGVFADVKNYKRRSKIWLTILLTLILSCAVMEKIAGDKDW       130       140       150       160       170       180      180       190       200       210       220 m084.pepREPDAGLLLNIFDLYYDLAXRAGTICRQARPHFGSSKKSVNMAYPSCCAQVX||||||||||||||||||| |||||||||||||||||||||||||  ||||| g084REPDAGLLLNIFDLYYDLAFRAGTICRQARPHFGSSKKSVNMAYPPTCAQVX       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 263>:

a084.seq 1 ATGAAACAAT CCGCCCGAAT AAAAAATATG GATCAGACAT TAAAAAATAC 51ATTGGGCATT TGCGCGCTTT TAGCCTTTTG TTTTGGCGCG GCCATCGCAT 101 CAGGTTATCACTTGGAATAT GAATACGGCT ACCGTTATTC TGCCGTGGGT 151 GCTTTGGCTT CGGTTGTATTTTTATTATTA TTGGCACGCG GTTTCCCGCG 201 CGTTTCTTCA GTTGTTTTAC TGATTTACGTCGGCACAACC GCCCTATATT 251 TGCCGGTCGG CTGGCTGTAT GGTGCGCCGT CTTATCAGATAGTCGGTTCG 301 ATATTGGAAA GCAATCCTGC CGAGGCGCGT GAATTTGTCG GCAATCTTCC351 CGGGTCGCTT TATTTTGTGC AGGCATTATT TTTCATTTTT GGCTTGACAG 401TTTGGAGATA TTGTGTATCG GGGGGGGTAT TTGCTGACGT AAAAAACTAT 451 AAACGCCGCAGCAAAATATG GCTGACTATA TTATTGACTT TGATTTTGTC 501 CTGCGCGGTG ATGGATAAAATCGCCAGCGA TAAAGATTTG CGAGAACCTG 551 ATGCCGGCCT GTTGTTGAAT ATTTTCGACCTGTATTACGA TTTGGCTTCC 601 .GCGCCGGCA CAATATGCCG CCAAGCGCGC CCACATTTTGGAAGCAGCAA 651 AAAAAGCGTC AACATGGCAT ATCCGTCATG TTGCGCCCAA GTATAAThis corresponds to the amino acid sequence <SEQ ID 264; ORF 084.a>:

a084.pep 1 MKQSARIKNM DQTLKNTLGI CALLAFCFGA AIASGYHLEY EYGYRYSAVG 51ALASVVFLLL LARGFPRVSS VVLLIYVGTT ALYLPVGWLY GAPSYQIVGS 101 ILESNPAEAREFVGNLPGSL YFVQALFFIF GLTVWRYCVS GGVFADVKNY 151KRRSKIWLTI LLTLILSCAV MDKIASDKDL REPDAGLLLN IFDLYYDLAS 201 XAGTICRQARPHFGSSKKSV NMAYPSCCAQ V* m084/a084 92.2% identity over a 231 aa overlap        10        20        30        40        50        60 m084.pepMKQSARIKXMNQTLLYTLGICALLTFXXXXXXXXXYHPEYEYGYRYSAVGALASVVFLLL|||||||| |:|||  ||||||||:|         || |||||||||||||||||||||| a084MKQSARIKNMDQTLKNTLGICALLAFCFGAAIASGYHLEYEYGYRYSAVGALASVVFLLL        10        20        30        40        50        60        70        80        90       100       110       120 m084.pepLARGFPRVSSVVLLIYVGTTALYLPVGWLYGAPSYQIVGSILESNPAEAREFVGNLPGSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a084LARGFPRVSSVVLLIYVGTTALYLPVGWLYGAPSYQIVGSILESNPAEAREFVGNLPGSL        70        80        90       100       110       120       130       140       150       160       170       180 m084.pepYFVQALFFIFGLTVWKYCVSGGVFADVKNYKRRSKIWLTILLTLILSCAVMDKIASDKDL|||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||| a084YFVQALFFIFGLTVWRYCVSGGVFADVKNYKRRSKIWLTILLTLILSCAVMDKIASDKDL       130       140       150       160       170       180       190       200       210       220       230 m084.pepREPDAGLLLNIFDLYYDLAXRAGTICRQARPHFGSSKKSVNMAYPSCCAQVX|||||||||||||||||||  ||||||||||||||||||||||||||||||| a084REPDAGLLLNIFDLYYDLASXAGTICRQARPHFGSSKKSVNMAYPSCCAQVX       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 265>:

g085.seq 1 ATGGGCAAAG GGCAGGACTT CACGCCCCTG CGCGACGCGT TGAAAGATAA 51GGCAAAAGGC GTGTTCCTGA TCGGCGTCGA TGCGCCGCAA ATCCGCCGCG 101 ATTTGGACGGCTGCGGCTTG AACCTGACCG ACTGCGTCAC TTTGGAAGAG 151 GCGGTTCAGA CGGCATACGCCCAAGCCGAA GCGGGCGATA TTGTCTTGCT 201 CAGCCCCGCC TGCGCGAGTT TCGATATGTTTAAAGGCTAC GCGCACCGTT 251 CGGAAGTGTT tatCGAAGCG TTTAAGGCTT TGTGAThis corresponds to the amino acid sequence <SEQ ID 266; ORF 085.ng>:

g085.pep 1 MGKGQDFTPL RDALKDKAKG VFLIGVDAPQ IRRDLDGCGL NLTDCVTLEE 51AVQTAYAQAE AGDIVLLSPA CASFDMFKGY AHRSEVFIEA FKAL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 267>:

m085.seq 1 ATGGGTAAAG GGCAGGACTT CACGCCCCTG CGCGATGCAC TGGTAGGCAA 51GGCAAAAGGC GTGTTCTTGA TTGGTGTCGA TGCGCCGCAA ATCCGCCGCG 101 ATTTGGACGGCTGCGGCTTG AATATGACCG ACTGCGCCAC TTTGGGAGAA 151 GCCGTTCAGA CGGCATATGCCCAAGCCGAA GCAGGCGATA TTGTGTTGCT 201 CAGCCCCGCC TGCGCGAGCT TTGATATGTTCAAAGGCTAC GCGCACCGTT 251 CGGAAGTGTT TATCGAAGCG TTTAAGGCTT TGTGAThis corresponds to the amino acid sequence <SEQ ID 268; ORF 085>:

m085.pep 1 MGKGQDFTPL RDALVGKAKG VFLIGVDAPQ IRRDLDGCGL NMTDCATLGE 51AVQTAYAQAE AGDIVLLSPA CASFDMFKGY AHRSEVFIEA FKAL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 085 shows 94.7% identity over a 94 aa overlap with a predicted ORF(ORF 085.ng) from N. gonorrhoeae:

m085/g085         10        20        30        40        50        60m085.pep MGKGQDFTPLRDALVGKAKGVFLIGVDAPQIRRDLDGCGLNMTDCATLGEAVQTAYAQAE||||||||||||||  |||||||||||||||||||||||||:|||:|| ||||||||||| g085MGKGQDFTPLRDALKDKAKGVFLIGVDAPQIRRDLDGCGLNLTDCVTLEEAVQTAYAQAE        10        20        30        40        50        60        70        80        90 m085.pepAGDIVLLSPACASFDMFKGYAHRSEVFIEAFKALX |||||||||||||||||||||||||||||||||||g085 AGDIVLLSPACASFDMFKGYAHRSEVFIEAFKALX         70        80        90The following partial DNA sequence was identified in N. meningitidis<SEQ ID 269>:

a085.seq 1 ATGGGCAAAG GGCAGGACTT CACGCCCCTG CGCGACGCGC TTGCCGGCAA 51GGCAAAAGGC GTGTTCCTGA TCGGTGTCGA TGCGCCGCAA ATCCGCCGCG 101 ATTTGGACGGCTGCGATCTG AATATGACCG ACTGCGCCAC TTTGGAAGAA 151 GCGGTTCAGA AGGCATATGCCCAAGCCGAA GCGGGCGATA TCGTGCTGCT 201 CAGCCCCGCC TGCGCGAGTT TCGATATGTTTAAAGGCTAC GCGCACCGTT 251 CGGAAGTGTT TATCGGGGCG TTTAAGGCTT TGTGAThis corresponds to the amino acid sequence <SEQ ID 270; ORF 085.a>:

a085.pep 1 MGKGQDFTPL RDALAGKAKG VFLIGVDAPQ IRRDLDGCDL NMTDCATLEE 51AVQKAYAQAE AGDIVLLSPA CASFDMFKGY AHRSEVFIGA FKAL* m085/a085 94.7%identity over a 94 aa overlap        10        20        30        40        50        60 m085.pepMGKGQDFTPLRDALVGKAKGVFLIGVDAPQIRRDLDGCGLNMTDCATLGEAVQTAYAQAE||||||||||||||:||||||||||||||||||||||| ||||||||| |||| |||||| a085MGKGQDFTPLRDALAGKAKGVFLIGVDAPQIRRDLDGCDLNMTDCATLEEAVQKAYAQAE        10        20        30        40        50        60        70        80        90 m085.pepAGDIVLLSPACASFDMFKGYAHRSEVFIEAFKALX |||||||||||||||||||||||||||| ||||||a085 AGDIVLLSPACASFDMFKGYAHRSEVFIGAFKALX         70        80        90The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 271>:

g086.seq 1 ATGGTGGTGC TGATGACGGC GTTCGGCCTG CTGATGATTT ATTCGGCTTC 51TGTGTATTTG GCATCGAAGG AAGGCGGCGA TCAGTTTTTC TATTTGACCA 101 GGCAGGCGGGGTTCGTCGTT GCCGGCCTTA TAGCGAGCGG TTTTTTATGG 151 TTTCTTTGCA GGATGAGGACATGGCGGCGG CTTGTGCCGT GGATTTTTGC 201 CTTATCCGGC CTGTTGCTGG TAGCCGTATTGATTGCCGGG CGCGAAATCA 251 ATGGCGCGAC CCGTTGGATA CCTTTGGGTC CGTTGAATTTCCAGCCGACC 301 GAGCTGTTCA AGCTGGCAGT CATCCTTTAT TTGGCAAGCC TGTTCACGCG351 CCGTGAAGAA GTGTTGCGCA GCATGGAAAG TTTGGGTTGG CAGTCGATTT 401GGCGGGGGAC GGCCAACCTG ATTATGTCCG CCACCAATCC GCAGGCACGT 451 CGTGAAACATTAGAAATGTA CGgcCGTTTC CGGGCGATCA TCCTGCCGAT 501 TATGCTGGTG GCGTTCGGTTTGGTGCTGAT AATGGTACAG CCGGATTTCG 551 GTTCGTTTGT CGTCATTACC GTCATTACCGTTGGAATGCT GTTTCTGGCA 601 GGATTGCCGT GGAAATATTT TTTTGTCCTG GTAGGCAGCGTCTTGGGTGG 651 GATGGTGCTG ATGATTACCG CCGCTCCCTA CCGTGTGCAG CGGGTAGTGG701 CATTTTTGGA CCCGTGGAAA GACCCGCAGG GTGCCGGCTA CCAGCTTACC 751CACTCTCTGA TGGCAATCGG GCGCGGAGAG TGGTTCGGTA TGGGTTTGGG 801 TGCGAGTTTGAGCAAACGCG GCTTTCTGCC GGAAGCGCAT ACCGATTTTA 851 TTTTTGCCAT CATCGCTGAAGAATTCGGCT TCTTCGGGAT GTGCGTGCTG 901 ATATTCTGTT ACGGCTGGCT GGTGGTGCGGGCGTTTTCCA TCGGCAAGCA 951 GTCGCGCGAT TTGGGtttgA CTTTCAACGC CTATATCGCTTCGGGTATCG 1001 GCATTTGGAT CGGTATCCAA AGTTTCTTCA ATATCGGTGT GAACATCGGT1051 GCTTTGCCGA CCAAAGGTCT GACGctgCcg tTGATGTCCT ATGGcggTTC 1101GTCAGTCTTT TTCATGCTGA TCAGCATGAT GCTGCTGTTG CGTATCGATT 1151 ATGAAAACCGCCAGAAAATG CGCGGTTACC GGGTGGAGTA AAThis corresponds to the amino acid sequence <SEQ ID 272; ORF 086.ng>:

g086.pep 1 MVVLMTAFGL LMIYSASVYL ASKEGGDQFF YLTRQAGFVV AGLIASGFLW 51FLCRMRTWRR LVPWIFALSG LLLVAVLIAG REINGATRWI PLGPLNFQPT 101 ELFKLAVILYLASLFTRREE VLRSMESLGW QSIWRGTANL IMSATNPQAR 151 RETLEMYGRFRAIILPIMLV AFGLVLIMVQ PDFGSFVVIT VITVGMLFLA 201GLPWKYFFVL VGSVLGGMVL MITAAPYRVQ RVVAFLDPWK DPQGAGYQLT 251 HSLMAIGRGEWFGMGLGASL SKRGFLPEAH TDFIFAIIAE EFGFFGMCVL 301 IFCYGWLVVR AFSIGKQSRDLGLTFNAYIA SGIGIWIGIQ SFFNIGVNIG 351 ALPTKGLTLPLMSYGGSSVF FMLISMMLLL RIDYENRQKM RGYRVE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 273>:

m086.seq 1 ATGGTGGTGC TGATGACGGC GTTCAGCCTG CTGATGATTT ATTCGGCTTC 51TGTGTATTTG GCATCAAAAG AAGGCGGCGA TCAGTTTTTC TATTTGACCA 101 GACAGGCGGGGTTCGTCGTT GCCGGCTTGA TAGCGAGCGG TTTGTTATGG 151 TTTCTTTGCA GGATGAGGACATGGCGGCGG CTTGTGCCGT GGATTTTTGC 201 CCTATCCGGC CTGTTGCTGG TAGTCGTATTGATTGCCGGG CGCGAAATCA 251 ATGGCGCGAC CCGTTGGATA CCTTTGGGTC CGTTGAATTTCCAGCCGACc 301 GAGCTGTTCA AGCtGGCGGT CATCCTTTAT TTGGCAAGCC TGTTCACGCG351 CCGTGAAGAA GTGTTGcGCA GCATGGAAAG TTTGGGTTGG CAGTCGATTT 401GGCGGGGGAC GGCCAATCTG ATCATGTCCG CCACCAATCC GCAGrCACGT 451 CGTGAaACATTAGAAATGTA CGGCCGTwTC CGGGCGATCA TCCTGCCGAT 501 TATGCTGGTG GCGTTCGGTTTGGTGCTGAT AATGGTACAG CCGGATTTCG 551 GTTCGTTTGT CGTCATTACC GTCATTGCCGTTGGAATGCT GTTTTTGGCA 601 GGATTGCCGT GGAAATATTT TTTCGTCCTG GTAGGCAGCGTCTTGGGCGG 651 GATGGTGCTG ATGATTACCG CCGCTCCCTA CCGTGTGCAG CGGGTAGTGG701 CATTTTTGGA CCCGTGGAAA GACCCGCAGG GTGCCGGCTA CCAGCTTACC 751CACTCTCTGA TGGCAATCGG GCGCGGAGAG TGGTTCGGTA TGGGTTTGGG 801 TGCGAGTTTGAGCAAACGCG GCTTTCTGCC GGAAGCGCAT ACCGATTTTA 851 TTTTTGCCAT CATCGCCGAAGAATTCGGTT TCTTCGGTAT GTGCGTGCTG 901 ATATTCTGTT ACGGCTGGCT GGTGGTGCGGGCGTTTTCCA TCGGCAAGCA 951 GTCGCGCGAT TTGGGTTTGA CTTTCAACGC CTATATCGCTTCGGGTATCG 1001 GCATTTGGAT CGGkrTCCAA AGTTTCTTCA ATATCGGTGT GAACATCGGT1051 GCTTTGCCGA mCAAAgGyCT GACGCyGCCG Tg.AtGTCCw ATGGCGGTTC 1101GTCAGTCTTT TTCATGCTGA TCAGCATGAT GCTGCTGTkG CGTATAGATT 1151 ATGAAAACCGCCGGAAAATG CGCGGTTATC GGGTGGAGTA AThis corresponds to the amino acid sequence <SEQ ID 274; ORF 086>:

m086.pep 1 MVVLMTAFSL LMIYSASVYL ASKEGGDQFF YLTRQAGFVV AGLIASGLLW 51FLCRMRTWRR LVPWIFALSG LLLVVVLIAG REINGATRWI PLGPLNFQPT 101 ELFKLAVILYLASLFTRREE VLRSMESLGW QSIWRGTANL IMSATNPQXR 151 RETLEMYGRXRAIILPIMLV AFGLVLIMVQ PDFGSFVVIT VIAVGMLFLA 201GLPWKYFFVL VGSVLGGMVL MITAAPYRVQ RVVAFLDPWK DPQGAGYQLT 251 HSLMAIGRGEWFGMGLGASL SKRGFLPEAH TDFIFAIIAE EFGFFGMCVL 301 IFCYGWLVVR AFSIGKQSRDLGLTFNAYIA SGIGIWIGXQ SFFNIGVNIG 351 ALPXKGLTXPXMSXGGSSVF FMLISMMLLX RIDYENRRKM RGYRVE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 086 shows 96.7% identity over a 396 aa overlap with a predicted ORF(ORF 086.ng) from N. gonorrhoeae:

m086/g086         10        20        30        40        50        60m086.pep MVVLMTAFSLLMIYSASVYLASKEGGDQFFYLTRQAGFVVAGLIASGLLWFLCRMRTWRR||||||||:||||||||||||||||||||||||||||||||||||||:|||||||||||| g086MVVLMTAFGLLMIYSASVYLASKEGGDQFFYLTRQAGFVVAGLIASGFLWFLCRMRTWRR        10        20        30        40        50        60        70        80        90       100       110       120 m086.pepLVPWIFALSGLLLVVVLIAGREINGATRWIPLGPLNFQPTELFKLAVILYLASLFTRREE||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||| g086LVPWIFALSGLLLVAVLIAGREINGATRWIPLGPLNFQPTELFKLAVILYLASLFTRREE        70        80        90       100       110       120       130       140       150       160       170       180 m086.pepVLRSMESLGWQSIWRGTANLIMSATNPQXRRETLEMYGRXRAIILPIMLVAFGLVLIMVQ|||||||||||||||||||||||||||| |||||||||| |||||||||||||||||||| g086VLRSMESLGWQSIWRGTANLIMSATNPQARRETLEMYGRFRAIILPIMLVAFGLVLIMVQ       130       140       150       160       170       180       190       200       210       220       230       240 m086.pepPDFGSFVVITVIAVGMLFLAGLPWKYFFVLVGSVLGGMVLMITAAPYRVQRVVAFLDPWK||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| g086PDFGSFVVITVITVGMLFLAGLPWKYFFVLVGSVLGGMVLMITAAPYRVQRVVAFLDPWK       190       200       210       220       230       240       250       260       270       280       290       300 m086.pepDPQGAGYQLTHSLMAIGRGEWFGMGLGASLSKRGFLPEAHTDFIFAIIAEEFGFFGMCVL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g086DPQGAGYQLTHSLMAIGRGEWFGMGLGASLSKRGFLPEAHTDFIFAIIAEEFGFFGMCVL       250       260       270       280       290       300       310       320       330       340       350       360 m086.pepIFCYGWLVVRAFSIGKQSRDLGLTFNAYIASGIGIWIGXQSFFNIGVNIGALPXKGLTXP|||||||||||||||||||||||||||||||||||||| ||||||||||||||:|||| | g086IFCYGWLVVRAFSIGKQSRDLGLTFNAYIASGIGIWIGIQSFFNIGVNIGALPTKGLTLP       310       320       330       340       350       360       370       380       390 m086.pepXMSXGGSSVFFMLISMMLLXRIDYENRRKMRGYRVEX || ||||||||||||||| |||||||:||||||||| g086LMSYGGSSVFFMLISMMLLLRIDYENRQKMRGYRVEX        370       380       390The following partial DNA sequence was identified in N. meningitidis<SEQ ID 275>:

a086.seq 1 ATGGTGGTGC TGATGACGGC GTTCAGCCTG CTGATGATTT ATTCGGCTTC 51TGTGTATTTG GCATCAAAAG AAGGCGGCGA TCAGTTTTTC TATTTGACCA 101 GACAGGCGGGGTTCGTCGTT GCCGGCTTGA TAGCGAGCGG TTTGTTATGG 151 TTTCTTTGCA GGATGAGGACATGGCGGCGG CTTGTGCCGT GGATTTTTGC 201 CCTATCCGGC CTGTTGCTGG TAGTCGTATTGATTGCCGGG CGCGAAATCA 251 ATGGCGCGAC CCGTTGGATA CCTTTGGGTC CGTTGAATTTCCAGCCGACC 301 GAGCTGTTCA AGCTGGCGGT CATCCTTTAT TTGGCAAGCC TGTTCACGCG351 CCGTGAAGAA GTGTTGCGCA GCATGGAAAG TTTGGGTTGG CAGTCGATTT 401GGCGGGGGAC GGCCAATCTG ATCATGTCCG CCACCAATCC GCAGGCACGT 451 CGTGAAACATTAGAAATGTA CGGCCGTTTC CGGGCGATCA TCCTGCCGAT 501 TATGCTGGTG GCGTTCGGTTTGGTGCTGAT AATGGTACAG CCGGATTTCG 551 GTTCGTTTGT CGTCATTACC GTCATTGCCGTTGGAATGCT GTTTTTGGCA 601 GGATTGCCGT GGAAATATTT TTTCGTCCTG GTAGGCAGCGTCTTGGGCGG 651 GATGGTGCTG ATGATTACCG CCGCTCCCTA CCGTGTGCAG CGGGTAGTGG701 CATTTTTGGA CCCGTGGAAA GACCCGCAGG GTGCCGGCTA CCAGCTTACC 751CACTCTCTGA TGGCAATCGG GCGCGGAGAG TGGTTCGGTA TGGGTTTGGG 801 TGCGAGTTTGAGCAAACGCG GCTTTCTGCC GGAAGCGCAT ACCGATTTTA 851 TTTTTGCCAT CATCGCCGAAGAATTCGGTT TCTTCGGTAT GTGCGTGCTG 901 ATATTCTGTT ACGGCTGGCT GGTGGTGCGGGCGTTTTCCA TCGGCAAGCA 951 GTCGCGCGAT TTGGGTTTGA CTTTCAACGC CTATATCGCTTCGGGTATCG 1001 GCATTTGGAT CGGTATCCAA AGTTTCTTCA ATATCGGTGT GAACATCGGT1051 GCTTTGCCGA CCAAAGGTCT GACGCTGCCG TTGATGTCCT ATGGCGGTTC 1101GTCAGTCTTT TTCATGCTGA TCAGCATGAT GCTGCTGTTG CGTATAGATT 1151 ATGAAAACCGCCGGAAAATG CGCGGTTACC GGGTGGAGTA AThis corresponds to the amino acid sequence <SEQ ID 276; ORF 086.a>:

a086.pep 1 MVVLMTAFSL LMIYSASVYL ASKEGGDQFF YLTRQAGFVV AGLIASGLLW 51FLCRMRTWRR LVPWIFALSG LLLVVVLIAG REINGATRWI PLGPLNFQPT 101 ELFKLAVILYLASLFTRREE VLRSMESLGW QSIWRGTANL IMSATNPQAR 151 RETLEMYGRFRAIILPIMLV AFGLVLIMVQ PDFGSFVVIT VIAVGMLFLA 201GLPWKYFFVL VGSVLGGMVL MITAAPYRVQ RVVAFLDPWK DPQGAGYQLT 251 HSLMAIGRGEWFGMGLGASL SKRGFLPEAH TDFIFAIIAE EFGFFGMCVL 301 IFCYGWLVVR AFSIGKQSRDLGLTFNAYIA SGIGIWIGIQ SFFNIGVNIG 351 ALPTKGLTLPLMSYGGSSVF FMLISMMLLL RIDYENRRKM RGYRVE* m086/a086 98.0% identity over a396 aa overlap        10        20        30        40        50        60 m086.pepMVVLMTAFSLLMIYSASVYLASKEGGDQFFYLTRQAGFVVAGLIASGLLWFLCRMRTWRR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a086MVVLMTAFSLLMIYSASVYLASKEGGDQFFYLTRQAGFVVAGLIASGLLWFLCRMRTWRR        10        20        30        40        50        60        70        80        90       100       110       120 m086.pepLVPWIFALSGLLLVVVLIAGREINGATRWIPLGPLNFQPTELFKLAVILYLASLFTRREE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a086LVPWIFALSGLLLVVVLIAGREINGATRWIPLGPLNFQPTELFKLAVILYLASLFTRREE        70        80        90       100       110       120       130       140       150       160       170       180 m086.pepVLRSMESLGWQSIWRGTANLIMSATNPQXRRETLEMYGRXRAIILPIMLVAFGLVLIMVQ|||||||||||||||||||||||||||| |||||||||| |||||||||||||||||||| a086VLRSMESLGWQSIWRGTANLIMSATNPQARRETLEMYGRFRAIILPIMLVAFGLVLIMVQ       130       140       150       160       170       180       190       200       210       220       230       240 m086.pepPDFGSFVVITVIAVGMLFLAGLPWKYFFVLVGSVLGGMVLMITAAPYRVQRVVAFLDPWK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a086PDFGSFVVITVIAVGMLFLAGLPWKYFFVLVGSVLGGMVLMITAAPYRVQRVVAFLDPWK       190       200       210       220       230       240       250       260       270       280       290       300 m086.pepDPQGAGYQLTHSLMAIGRGEWFGMGLGASLSKRGFLPEAHTDFIFAIIAEEFGFFGMCVL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a086DPQGAGYQLTHSLMAIGRGEWFGMGLGASLSKRGFLPEAHTDFIFAIIAEEFGFFGMCVL       250       260       270       280       290       300       310       320       330       340       350       360 m086.pepIFCYGWLVVRAFSIGKQSRDLGLTFNAYIASGIGIWIGXQSFFNIGVNIGALPXKGLTXP|||||||||||||||||||||||||||||||||||||| ||||||||||||||:|||| | a086IFCYGWLVVRAFSIGKQSRDLGLTFNAYIASGIGIWIGIQSFFNIGVNIGALPTKGLTLP       310       320       330       340       350       360       370       380       390 m086.pepXMSXGGSSVFFMLISMMLLXRIDYENRRKMRGYRVEX || ||||||||||||||| ||||||||||||||||| a086LMSYGGSSVFFMLISMMLLLRIDYENRRKMRGYRVEX        370       380       390The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 277>:

g087.seq 1 ATGGGCGGTA AAACCTTTAT GCTGATGGCG GGCGGAACGG GCGGACACAT 51TTTCCCAGCT CTGGCTGTGG CGGATTCATT GCGCGTGCGC GGTCATCATG 101 TAATTTGGCTGGGCAGCAAG GATTCGATGG AAGAGCGCAT CGTGCCGCAA 151 TACGGCATAC GCTTGGAAACGCTGGCGATT AAAGGAATAC GCGGCAACGG 201 CATCAAACGC AAGCTGATGC TTCCGTTTACTCTGTACAAA ACCGTCCGCG 251 AAGCGCAGCG GATTATCCGC AAACACCGTG TCGAGTGCGTCATCGGCTTC 301 GGCGGTTTTG TTACCTTTCC CGGCGGTCTG GCGGCGAAAC TCTTGGGCGT351 GCCGATTGTG ATTCACGAGC AAAACGCCGT GGCAGGCTTG TCCAACCGCC 401AccTGTCGCg ctGGGCGAAA CGGGTGTTGT ACGCTTTTCC GAAAGCGTTC 451 AGCCACGAAGGCGGTTTGGT CGGCAACCCC GTCCGCGCCG ATATTAGCAA 501 CCTGCCCGTG CCTGCCGAACGCTTCCAAGG GCGCGAAGGC CGTCTGAAAA 551 TTTTGGTGGT CGGCGGCAGT TTGGGTGCGGACGTTTTGAA CAAAACCGTA 601 CCGCAGGCGT TGGCACTGCT GCCTGAAGAG GTGCGCCCGCAGATGTACCA 651 CCAGTCGGGG CGTAACAAGC TGGGCAATCT TCAGGCGGAT TATGACGCGT701 TGGGCGTGAA AGCGGAATGC GTGGAATTTA TTACCGACAT GGTGTCCGCC 751TACCGTGATG CCGATTTGGT GATTTGCCGT GCCGGCGCGC TGACGATTGC 801 CGAGTTGACGGCGGCGGGGC TGGGCGCGTT GTTAGTGCCG TATCCTCACG 851 CCGTTGATGA CCATCAAACCGCCAACGCGC GTTTCATGGT GCAGGCAGAA 901 GCGGGGCTGC TGTTGCCGCA AACCCAGTTGACGGCGGAAA AACTCGCCGA 951 AATCCTCGGC AGCCTCAACC GCGAAAAATG CCTCAAATGGGCGGAAAACG 1001 CCCGTACGTT GGCATTGCCG CACAGCGCGG ATGACGTTGC CGAAGCCGCG1051 ATTGCGTGTG CGGCGTAAAThis corresponds to the amino acid sequence <SEQ ID 278; ORF 087.ng>:

g087.pep 1 MGGKTFMLMA GGTGGHIFPA LAVADSLRVR GHHVIWLGSK DSMEERIVPQ 51YGIRLETLAI KGIRGNGIKR KLMLPFTLYK TVREAQRIIR KHRVECVIGF 101GGFVTFPGGL AAKLLGVPIV IHEQNAVAGL SNRHLSRWAK RVLYAFPKAF 151 SHEGGLVGNPVRADISNLPV PAERFQGREG RLKILVVGGS LGADVLNKTV 201 PQALALLPEE VRPQMYHQSGRNKLGNLQAD YDALGVKAEC VEFITDMVSA 251 YRDADLVICR AGALTIAELT AAGLGALLVPYPHAVDDHQT ANARFMVQAE 301 AGLLLPQTQL TAEKLAEILG SLNREKCLKW AENARTLALPHSADDVAEAA 351 IACAA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 279>:

m087.seq 1 ATGGGCGGTA AAACCTTTAT GCTGAwkkCG GGCGGAACGG GCGGACATAT 51TTTCCCCGCG CTGGCGGTGG CGGATTCATT GCGCGCGCGC GGCCATCATG 101 TGATTTGGCTGGGCAGCAAG GATTCGATGG AAGAGCGTAT CGTGCCGCAA 151 TACGGCATAC GCTTGGAAACGCTGGCGATT AAAGGCGTGC GCGGCAACGG 201 CATCAAACGC AAACTGATGC TGCCGGTTACTTTGTATCAA ACCGTCCGCG 251 AAGCGCAGCG GATTATCCGC AAACACCGTG TCGAGTGCGTCATCGGCTTC 301 GGCGGCTTCG TTACCTTCCC CGGCGGTTTG GCGGCGAAGC TATTArGCGT351 GCCGATTGTG ATTCACGAGC AAAACGCCGT GGCAGGTTTG TCCAACCGCC 401ACCTGTCGCG CTGGGCGAAG CGGGTGTTGT ACGCTTTTCC GAAAGCGTTC 451 AGCCACGAAGGCGGCTTGGT CGGCAACCCC GTCCGCGCCG ATATTAGCAA 501 CCTGCCCGTG CCTGCCGAACGCTTCCAAGG GCGTGAAGGC CGTCTGAAAA 551 TTTTGGTGGT CGGCGGCAGT TTGGGCGCGGACGTTTTGAA CAAAACCGTA 601 CCGCATGCAT TGGCTTTGCT GCCCGACAAT GCGCGTCCGCATATGTACCA 651 CCAATCGGGA CGGGGCAAGC TGGGCATCTT GCAGGCGnnn nnnnnnnnnn701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 751nnnGCGGGAT TGGGTGCGTT GTTAGTGCCG TATCCTCACG CGGTTGACGA 801 TCACCAAACCGCCAACGCGC GTTTTATGGT GCAGGCGGAG GCGGGATTGC 851 TGTTGCCGCA AACCCAGTTGACGGCGGAAA AACTCGCCGA GATTCTCGGC 901 GGCTTAAACC GCGAAAAATG CCTCAAATGGGCAGAAAACG CCCGTACGTT 951 GGCACTGCCG CACAGTGCGG ACGACGTGGC GGAAGCCGCGATTGCGTGTG 1001 CGGCGTAAThis corresponds to the amino acid sequence <SEQ ID 280; ORF 087>:

m087.pep 1 MGGKTFMLXX GGTGGHIFPA LAVADSLRAR GHHVIWLGSK DSMEERIVPQ 51YGIRLETLAI KGVRGNGIKR KLMLPVTLYQ TVREAQRIIR KHRVECVIGF 101GGFVTFPGGL AAKLLXVPIV IHEQNAVAGL SNRHLSRWAK RVLYAFPKAF 151 SHEGGLVGNPVRADISNLPV PAERFQGREG RLKILVVGGS LGADVLNKTV 201 PHALALLPDN ARPHMYHQSGRGKLGILQAX XXXXXXXXXX XXXXXXXXXX 251 XAGLGALLVP YPHAVDDHQT ANARFMVQAEAGLLLPQTQL TAEKLAEILG 301 GLNREKCLKW AENARTLALP HSADDVAEAA IACAA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 087 shows 83.9% identity over a 355 aa overlap with a predicted ORF(ORF 087.ng) from N. gonorrhoeae:

m087/g087          10        20        30        40        50        60m087.pep  MGGKTFMLXXGGTGGHIFPALAVADSLRARGHHVIWLGSKDSMEERIVPQYGIRLETLAI ||||||||  ||||||||||||||||||:||||||||||||||||||||||||||||||| g087 MGGKTFMLMAGGTGGHIFPALAVADSLRVRGHHVIWLGSKDSMEERIVPQYGIRLETLAI         10        20        30        40        50        60         70        80        90       100       110       120 m087.pep KGVRGNGIKRKLMLPVTLYQTVREAQRIIRKHRVECVIGFGGFVTFPGGLAAKLLXVPIV ||:|||||||||||| |||:||||||||||||||||||||||||||||||||||| |||| g087 KGIRGNGIKRKLMLPFTLYKTVREAQRIIRKHRVECVIGFGGFVTFPGGLAAKLLGVPIV         70        80        90       100       110       120        130       140       150       160       170       180 m087.pep IHEQNAVAGLSNRHLSRWAKRVLYAFPKAFSHEGGLVGNPVRADISNLPVPAERFQGREG |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g087 IHEQNAVAGLSNRHLSRWAKRVLYAFPKAFSHEGGLVGNPVRADISNLPVPAERFQGREG        130       140       150       160       170       180        190       200       210       220      229 m087.pep RLKILVVGGSLGADVLNKTVPHALALLPDNARPHMYHQSGRGKLGILQA----------- |||||||||||||||||||||:||||||:::||:|||||||:||| ||| g087 RLKILVVGGSLGADVLNKTVPQALALLPEEVRPQMYHQSGRNKLGNLQADYDALGVKAEC        190       200       210       220       230       240                              230       240       250 m087.pep -------------------------------AGLGALLVPYPHAVDDHQTANARFMVQAE                                ||||||||||||||||||||||||||||| g087 VEFITDMVSAYRDADLVICRAGALTIAELTAAGLGALLVPYPHAVDDHQTANARFMVQAE        250       260       270       280       290       300260       270       280       290       300       310 m087.pep AGLLLPQTQLTAEKLAEILGGLNREKCLKWAENARTLALPHSADDVAEAAIACAAX ||||||||||||||||||||:||||||||||||||||||||||||||||||||||| g087 AGLLLPQTQLTAEKLAEILGSLNREKCLKWAENARTLALPHSADDVAEAAIACAAX        310       320       330       340       350The following partial DNA sequence was identified in N. meningitidis<SEQ ID 281>:

a087.seq 1 ATGGGCGGTA AAACCTTTAT GCTGATGGCG GGCGGAACGG GCGGACATAT 51TTTCCCCGCG CTGGCGGTGG CGGATTCATT GCGCGCGCGC GGCCATCATG 101 TAATTTGGCTGGGCAGCAAG GATTCGATGG AAGAGCGCAT CGTGCCGCAA 151 TACGACATCC TGCTCGAAACGCTGGCGATT AAAGGCGTGC GCGGCAACGG 201 CATCAAACGC AAGCTGATGC TGCCGTTTACTTTGTATCAA ACTGTCCGCG 251 AAGCGCAGCA GATTATCCGC AAACACCGTG TCGAGTGCGTCATCGGCTTC 301 GGCGGCTTCG TTACCTTTCC CGGCGGTTTG GCGGCGAAGT TATTAGGCGT351 GCCGATTGTG ATTCACGAGC AAAACGCCGT GGCAGGTTTG TCCAACCGCC 401ACCTGTCGCG CTGGGCGAAG CGGGTGTTGT ACGCTTTTCC GAAAGCGTTC 451 AGCCACGAAGGCGGCTTGGT CGGCAACCCC GTCCGCGCCG ATATTAGCAA 501 CCTGCCCGTG CCTGCCGAACGCTTCCAAGG GCGTGAAGGC CGTCTGAAAA 551 TTTTGGTGGT CGGCGGCAGT TTGGGCGCGGACGTTTTGAA CAAAACCGTA 601 CCGCAGGCAT TGGCTTTGCT GCCCGACAAT GCGCGTCCGCAGATGTACCA 651 CCAATCGGGA CGGGGCAAGC TGGGCAGCTT GCAGGCGGAT TACGACGCGC701 TGGGCGTGCA AGCGGAATGC GTGGAATTTA TTACCGATAT GGTGTCCGCC 751TACCGCGATG CCGATTTGGT GATTTGCCGT GCCGGCGCGC TGACGATTGC 801 CGAGTTGACGGCGGCGGGAT TGGGTGCGTT GTTAGTGCCG TATCCTCACG 851 CCGTTGATGA CCATCAAACCGCCAACGCGC GTTTTATGGT GCAGGCGGAG 901 GCGGGATTGC TGTTGCCGCA AACCCAGTTGACGGCGGAAA AACTCGCCGA 951 GATTCTCGGC GGCTTAAACC GCGAAAAATG CCTCAAATGGGCAGAAAACG 1001 CCCGTACGTT GGCACTGCCG CACAGTGCGG ACGACGTTGC CGAAGCCGCG1051 ATTGCGTGTG CGGCGTAAThis corresponds to the amino acid sequence <SEQ ID 282; ORF 087.a>:

a087.pep 1 MGGKTFMLMA GGTGGHIFPA LAVADSLRAR GHHVIWLGSK DSMEERIVPQ 51YDILLETLAI KGVRGNGIKR KLMLPFTLYQ TVREAQQIIR KHRVECVIGF 101GGFVTFPGGL AAKLLGVPIV IHEQNAVAGL SNRHLSRWAK RVLYAFPKAF 151 SHEGGLVGNPVRADISNLPV PAERFQGREG RLKILVVGGS LGADVLNKTV 201 PQALALLPDN ARPQMYHQSGRGKLGSLQAD YDALGVQAEC VEFITDMVSA 251 YRDADLVICR AGALTIAELT AAGLGALLVPYPHAVDDHQT ANARFMVQAE 301 AGLLLPQTQL TAEKLAEILG GLNREKCLKW AENARTLALPHSADDVAEAA 351 IACAA* m087/a087 85.4% identity over a 355 aa overlap        10        20        30        40        50        60 m087.pepMGGKTFMLXXGGTGGHIFPALAVADSLRARGHHVIWLGSKDSMEERIVPQYGIRLETLAI||||||||  ||||||||||||||||||||||||||||||||||||||||| | |||||| a087MGGKTFMLMAGGTGGHIFPALAVADSLRARGHHVIWLGSKDSMEERIVPQYDILLETLAI        10        20        30        40        50        60        70        80        90       100       110       120 m087.pepKGVRGNGIKRKLMLPVTLYQTVREAQRIIRKHRVECVIGFGGFVTFPGGLAAKLLXVPIV||||||||||||||| ||||||||||:|||||||||||||||||||||||||||| |||| a087KGVRGNGIKRKLMLPFTLYQTVREAQQIIRKHRVECVIGFGGFVTFPGGLAAKLLGVPIV        70        80        90       100       110       120       130       140       150       160       170       180 m087.pepIHEQNAVAGLSNRHLSRWAKRVLYAFPKAFSHEGGLVGNPVRADISNLPVPAERFQGREG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a087IHEQNAVAGLSNRHLSRWAKRVLYAFPKAFSHEGGLVGNPVRADISNLPVPAERFQGREG       130       140       150       160       170       180       190       200       210       220       230       240 m087.pepRLKILVVGGSLGADVLNKTVPHALALLPDNARPHMYHQSGRGKLGILQAXXXXXXXXXXX|||||||||||||||||||||:|||||||||||:||||||||||| ||| a087RLKILVVGGSLGADVLNKTVPQALALLPDNARPQMYHQSGRGKLGSLQADYDALGVQAEC       190       200       210       220       230       240                           250       260       270       280 m087.pepXX--------------------XXXXXXXXXAGLGALLVPYPHAVDDHQTANARFMVQAE                        :    : ||||||||||||||||||||||||||||| a087VEFITDMVSAYRDADLVICRAGALTIAELTAAGLGALLVPYPHAVDDHQTANARFMVQAE       250       260       270       280       290       300       290       300       310       320       330 m087.pepAGLLLPQTQLTAEKLAEILGGLNREKCLKWAENARTLALPHSADDVAEAAIACAAX|||||||||||||||||||||||||||||||||||||||||||||||||||||||| a087AGLLLPQTQLTAEKLAEILGGLNREKCLKWAENARTLALPHSADDVAEAAIACAAX       310       320       330       340       350The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 283>:

g088.seq 1 ATGTTTTTAT GGCTCGCACA TTTCAGCAAC TGGTTAACCG GTCTGAATAT 51TTTTCAATAC ACCACATTCC GCGCCGTTAT GGCGGCGTTG ACCGCCTTGG 101 CGTTTTCCCTGATGTTCGGC CCGTGGACGA TACGCAGGCT GACCGCGCTC 151 AAATGCGGGC AGGCAGTGCGTACCGACGGC CCGCAAACCC ACCTCGTCAA 201 AAACGGCACG CCGACGATGG GCGGTTCGCTGATTCTGACC GCCATTACCG 251 TGTCCACCCT GTTGTGGGGC AACTGGGCGA ACCCGTATATCTGGATTCTC 301 TTGGGCGTAC TGCTTGCCAC CGGTGCGCTC GGTTTTTACG ACGACTGGCG351 CAAAGTCGTT TATAAAGACC CCAACGGCGT GTCCGCCAAA TTCAAAATGG 401TGTGGCAGTC AAGCGTTGCC GTTatcgcCG GTttggcaTT GTTTTACctt 451 gCcgcCAATTCCGCCAACAA TATTTTGATT GTCCCGtttT TCAAACAAAT 501 CGCCCTGCCG CTGGGCGTGGTCGGCTTttt gGtgttgTCT TACCTGACCA 551 TCGTCGGCAC ATCCAACGCC GTCAACCTCACcgaCGGCTT GGACGGCCTT 601 GCCGCcttcc cgttcgtcct cgttgccgcC GGGCTCGCCAttttcgccTA 651 CGTCAGCGGA CACTACCAAT TTTCCCAATA CCTCCAGCTT CCCTATGTCG701 CCGGCGCGAA CGAAGTCGCT ATATTCTGCA CCGCCATGTG CGGCGCGTGC 751CTCGGATTTT TGTGGTTCAA CGCCTATCCC GCGCAAGTCT TTATGGGCGA 801 TGTCGGCGCGCTGGCATTGG GTGCCGCGCT CGGTaccGtt gCCGTcaTcg 851 tCCGCCAAGA ATTTGTcctcgtcattaTGG GCGGTCTGTT cgtcgtagaa 901 gccgtgTCCG TTATGCTTCa tgtcggCTGGTACAAGAAAA Ccaaaaaacg 951 CATCTTcCTg acgGcaccga ttcatcacca ttaCCaacttcgatgCTGGa 1001 aagaaacgca agtcgtcgtc CGTTtCTGGA TTAtTAccat cgtcgtggtt1051 tTgataggtt tGagtacccT caAAattcgc ggaaactatg ccgTCCGAAC 1101ACCTTTCAGA CGGCATTTGA ACGCGCAATA AThis corresponds to the amino acid sequence <SEQ ID 284; ORF 088.ng>:

g088.pep 1 MFLWLAHFSN WLTGLNIFQY TTFRAVMAAL TALAFSLMFG PWTIRRLTAL 51KCGQAVRTDG PQTHLVKNGT PTMGGSLILT AITVSTLLWG NWANPYIWIL 101LGVLLATGAL GFYDDWRKVV YKDPNGVSAK FKMVWQSSVA VIAGLALFYL 151 AANSANNILIVPFFKQIALP LGVVGFLVLS YLTIVGTSNA VNLTDGLDGL 201 AAFPFVLVAA GLAIFAYVSGHYQFSQYLQL PYVAGANEVA IFCTAMCGAC 251 LGFLWFNAYPAQVFMGDVGA LALGAALGTV AVIVRQEFVL VIMGGLFVVE 301 AVSVMLHVGW YKKTKKRIFLTAPIHHHYQL RCWKETQVVV RFWIITIVVV 351 LIGLSTLKIR GNYAVRTPFR RHLNAQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 285>:

m088.seq 1 ATGTTTTTAT GGCTCGCACA TTTCAGCAnC TGGTTAACCG GTCTGAATnn 51nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 101 nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 151 nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn 251 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnnnnnnnnnn 301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn351 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 401nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 451 nnnnnnnnnnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 501 nnnnnnnnnn nnnGGCGTGGTCGGCTTTTT GGTGTTGTCT TACCTGACCA 551 TCGTCGGCAC ATCCAATGCC GTCAACCTCACCGACGGCTT GGACGGCCTT 601 GCGACCTTCC CCGTCGTCCT CGTTGCCGCC GGCCTCGCCATCTTCGCCTA 651 TGCCAGCGGC CACTCACAAT TTGCCCAATA CCTGCAATTA CCTTACGTTG701 CCGGCGCAAA CGAAGTGGTG ATTTTCTGTA CCGCCATGTG CGGCGCGTGC 751CTCGGTTTCT TGTGGTTTAA CGCCTATCCC GCGCAAGTCT TTATGGGCGA 801 TGTCGGTGCATTGGCATTGG GTGCCGCGCT CGGTACCGTC GCCGTTATCG 851 TCCGCCAAGA GTTTGTCCTCGTCATTATGG GCGGATTATT TGTCGTAGAA 901 GCCGTATCCG TTATGCTTCA GGTTGGCTGGTATAAGAAAA CCAAAAAACG 951 CATCTTCCTG ATGGCGCCCA TCCATCACCA CTACGAACAAAAAGGCTGGA 1001 AAGAAACCCA AGTCGTCGTC CGCTTTTGGA TTATTACCAT CGTCTTGGTG1051 TTGATCGGTT TGAGTACCCT CAAAATCCGC TGAACCTATG CCGTCTGAAC 1101ATCTTTCAGA CGGCATTTGA ACGCGCAATA A 1 MFLWLAHFSN WLTGLNIFQYTTFRAVMAAL TALAFSLMFG PWTIRRLTAL 51 KCGQAVRTDG PQTHLVKNGTPTMGGSLILT AITVSTLLWG NWANPYIWIL 101 LGVLLATGAL GFYDDWRKVV YKDPNGVSAKFKMVWQSSVA VIAGLALFYL 151 AANSANNILI VPFFKQIALP LGVVGFLVLS YLTIVGTSNAVNLTDGLDGL 201 AAFPFVLVAA GLAIFAYVSG HYQFSQYLQL PYVAGANEVA IFCTAMCGAC251 LGFLWFNAYP AQVFMGDVGA LALGAALGTV AVIVRQEFVL VIMGGLFVVE 301AVSVMLHVGW YKKTKKRIFL TAPIHHHYQL RCWKETQVVV RFWIITIVVV 351 LIGLSTLKIRGNYAVRTPFR RHLNAQ*This corresponds to the amino acid sequence <SEQ ID 286; ORF 088>:

m088.pep 1 MFLWLAHFSX WLTGLNXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 51XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 101 XXXXXXXXXXXXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 151 XXXXXXXXXX XXXXXXXXXXXGVVGFLVLS YLTIVGTSNA VNLTDGLDGL 201 ATFPVVLVAA GLAIFAYASG HSQFAQYLQLPYVAGANEVV IFCTAMCGAC 251 LGFLWFNAYPAQVFMGDVGA LALGAALGTV AVIVRQEFVL VIMGGLFVVE 301 AVSVMLQVGW YKKTKKRIFLMAPIHHHYEQ KGWKETQVVV RFWIITIVLV 351 LIGLSTLKIR XTYAVXTSFR RHLNAQ*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.GonorrhoeaeORF 088 shows 91.7% identity over a 205 aa overlap with a predicted ORF(ORF 088.ng) from N. gonorrhoeae:

m088/g088                                       10        20        30m088.pep                               GVVGFLVLSYLTIVGTSNAVNLTDGLDGLA                              |||||||||||||||||||||||||||||| g088IAGLALFYLAANSANNILIVPFFKQIALPLGVVGFLVLSYLTIVGTSNAVNLTDGLDGLA      150       160       170       180       190       200        40        50        60        70        80        90 m088.pepTFPVVLVAAGLAIFAYASGHSQFAQYLQLPYVAGANEVVIFCTAMCGACLGFLWFNAYPA:|| ||||||||||||:||| ||:||||||||||||||:||||||||||||||||||||| g088AFPFVLVAAGLAIFAYVSGHYQFSQYLQLPYVAGANEVAIFCTAMCGACLGFLWFNAYPA      210       220       230       240       250       260       100       110       120       130       140       150 m088.pepQVFMGDVGALALGAALGTVAVIVRQEFVLVIMGGLFVVEAVSVMLQVGWYKKTKKRIFLM|||||||||||||||||||||||||||||||||||||||||||||:||||||||||||| g088QVFMGDVGALALGAALGTVAVIVRQEFVLVIMGGLFVVEAVSVMLHVGWYKKTKKRIFLT      270       280       290       300       310       320       160       170       180       190       200 m088.pepAPIHHHYEQKGWKETQVVVRFWIITIVLVLIGLSTLKIRXTYAVXTSFRRHLNAQX |||||||: :||||||||||||||||:||||||||||| :||| | ||||||||| g088APIHHHYQLRCWKETQVVVRFWIITIVVVLIGLSTLKIRGNYAVRTPFRRHLNAQX      330       340       350       360       370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 287>:

a088.seq 1 ATGTTTTTAT GGCTCGCACA TTTCAGCAAC TGGTTAACCG GTCTGAATAT 51TTTTCAATAC ACCACATTCC GCGCCGTCAT GGCGGCGTTG ACCGCCTTGG 101 CGTTTTCCCTGATGTTCGGC CCGTGGACGA TACGCAGGCT GACCGCGCTC 151 AAATGCGGGC AGGCAGTGCGTACCGACGGT CCGCAAACCC ACCTCGTCAA 201 AAACGGCACG CCGACGATGG GCGGTTCGCTGATTCTGACC GCCATTACCG 251 TGTCCACCCT GTTGTGGGGC AACTGGGCAA ACCCGTATATCTGGATTCTC 301 TTGGGCGTAT TGCTCGCCAC GGGCGCACTC GGTTTTTACG ACGACTGGCG351 CAAAGTCGTC TATAAAGACC CCAACGGCGT GTCCGCCAAA TTCAAAATGG 401TGTGGCAGTC AAGCGTTGCC ATTATCGCCG GTTTGGCATT GTTTTACCTT 451 GCCGCCAATTCCGCCAACAA TATTTTGATT GTCCCGTTCT TCAAACAAAT 501 CGCCCTGCCG CTGGGCGTGGTCGGCTTTTT GGTGTTGTCT TACCTGACCA 551 TCGTCGGCAC ATCCAATGCC GTCAACCTCACCGACGGCTT GGACGGCCTT 601 GCGACCTTCC CCGTCGTCCT CGTTGCCGCC GGCCTCGCCATCTTCGCCTA 651 TGCCAGCGGC CACTCACAAT TTGCCCAATA CCTGCAATTA CCTTACGTTG701 CCGGCGCAAA CGAAGTGGTG ATTTTCTGTA CCGCCATGTG CGGCGCGTGC 751CTCGGTTTCT TGTGGTTTAA CGCCTATCCC GCGCAAGTCT TTATGGGCGA 801 TGTCGGTGCATTGGCATTGG GTGCCGCGCT CGGTACCGTC GCCGTCATCG 851 TCCGCCAAGA GTTTGTCCTCGTCATTATGG GCGGATTATT TGTCGTAGAA 901 GCCGTATCCG TTATGCTTCA GGTCGGCTGGTATAAGAAAA CCAAAAAACG 951 CATCTTCCTG ATGGCGCCCA TCCATCACCA CTACGAACAAAAAGGCTGGA 1001 AAGAAACCCA AGTCGTCGTC CGCTTTTGGA TTATTACCAT CGTCTTGGTG1051 TTGATCGGTT TGAGTACCCT CAAAATCCGC TGAACCTATG CCGTCTGAAC 1101ACCTTTCAGA CGGCATTTGA ACGCGCAATA AThis corresponds to the amino acid sequence <SEQ ID 288; ORF 088.a>:

a088.pep 1 MFLWLAHFSN WLTGLNIFQY TTFRAVMAAL TALAFSLMFG PWTIRRLTAL 51KCGQAVRTDG PQTHLVKNGT PTMGGSLILT AITVSTLLWG NWANPYIWIL 101LGVLLATGAL GFYDDWRKVV YKDPNGVSAK FKMVWQSSVA IIAGLALFYL 151 AANSANNILIVPFFKQIALP LGVVGFLVLS YLTIVGTSNA VNLTDGLDGL 201 ATFPVVLVAA GLAIFAYASGHSQFAQYLQL PYVAGANEVV IFCTAMCGAC 251 LGFLWFNAYPAQVFMGDVGA LALGAALGTV AVIVRQEFVL VIMGGLFVVE 301 AVSVMLQVGW YKKTKKRIFLMAPIHHHYEQ KGWKETQVVV RFWIITIVLV 351 LIGLSTLKIR *TYAV*TPFR RHLNAQ*m088/a088 99.5% identity over a 205 aa overlap      150       160       170       180       190       200 m088.pepXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGVVGFLVLSYLTIVGTSNAVNLTDGLDGLA                              |||||||||||||||||||||||||||||| a088IAGLALFYLAANSANNILIVPFFKQIALPLGVVGFLVLSYLTIVGTSNAVNLTDGLDGLA      150       160       170       180       190       200      210       220       230       240       250       260 m088.pepTFPVVLVAAGLAIFAYASGHSQFAQYLQLPYVAGANEVVIFCTAMCGACLGFLWFNAYPA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a088TFPVVLVAAGLAIFAYASGHSQFAQYLQLPYVAGANEVVIFCTAMCGACLGFLWFNAYPA      210       220       230       240       250       260      270       280       290       300       310       320 m088.pepQVFMGDVGALALGAALGTVAVIVRQEFVLVIMGGLFVVEAVSVMLQVGWYKKTKKRIFLM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a088QVFMGDVGALALGAALGTVAVIVRQEFVLVIMGGLFVVEAVSVMLQVGWYKKTKKRIFLM      270       280       290       300       310       320      330       340       350       360       370 m088.pepAPIHHHYEQKGWKETQVVVRFWIITIVLVLIGLSTLKIRXTYAVXTSFRRHLNAQX|||||||||||||||||||||||||||||||||||||||||||||| ||||||||| a088APIHHHYEQKGWKETQVVVRFWIITIVLVLIGLSTLKIRXTYAVXTPFRRHLNAQX      330       340       350       360       370The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 289>:

g089.seq 1 ATGCCGCCCA AAATCACGAA GAGCGGGTTT TGCAAACCGG CAATCGCGGC 51GGCGGTCGCG CCGACATTCG TGCCTTTGCT GTCGTCGATG AATACCACGC 101 CGTTTTTCTCGCCGATTTTT TCCACACGGT GCGGCAAGCC TTGGAAGGTT 151 TTGACGTGTT CCAGCAATGCTTCGCGCGGC AAACCGACGG CCTCGCACAA 201 AGCCACGGCA GCCATAACGT TGGCGGCGTTGTGCAAACCT TGCAGCGGGA 251 TGTCTTGCGT AGAAATCAAA TCTTCATTGC CTTGTTTTAAACAGCCCGTC 301 CCGCGTTCCA ACCAAAAATC GGCTTCGTGT TCCAAGGAAA ACCGTTTCAC351 TTCACGCCCT GCCCGTTTCA TGGCGCGGCA GAACACGTCG TCCGCATTCA 401AAACCTGCAC TCCATCGCCA CGGAAAATCT CGGCTTTGGT ATGCGCGTAGThis corresponds to the amino acid sequence <SEQ ID 290; ORF 089.ng>:

g089.pep 1 MPPKITKSGF CKPAIAAAVA PTFVPLLSSM NTTPFFSPIF STRCGKPWKV 51LTCSSNASRG KPTASHKATA AITLAALCKP CSGMSCVEIK SSLPCFKQPV 101 PRSNQKSASCSKENRFTSRP ARFMARQNTS SAFKTCTPSP RKISALVCA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 291>:

m089.seq 1 ATGCCGCCCA AAATCACkAw GAGCGGATTT TGCAAACCGG CAATCGCGGC 51GGCAGTCGCG CCGACATTCG TGCCTTTGCT GTCGTCGATA AACACCACGC 101 CGTTTTTCTCGCCGATTTTT TCCACGCGGT GCGGCAGGCC TTGGAAGGTT 151 TTGACGTGTT CGAGCAATGCTTCGCGCGAC AAACCGATGG CCTCACACAA 201 AGCCACkGCA GCCATGACGT TAGCGGCGTTGTGCAkACCT TGCAACGGwA 251 TGTCTTGCGT GACAATCAAA TCTTCATTGC CTTGTTTCAGGCGGCCTGTC 301 TCGCGTTCCA ACCAGAAATC AGCTTCGTGT TCCAACGAAA ACCATTTTAC351 CTCGCGCCCG GCACGCTTCA TCGCGCGGCA GAACGCATCG TCCGCATTCA 401AAACCTGCAC GCCGTCGCCA CGGAAAATCT TGGCTTTGGT ATGCGCATAGThis corresponds to the amino acid sequence <SEQ ID 292; ORF 089>:

m089.pep 1 MPPKITXSGF CKPAIAAAVA PTFVPLLSSI NTTPFFSPIF STRCGRPWKV 51LTCSSNASRD KPMASHKATA AMTLAALCXP CNGMSCVTIK SSLPCFRRPV 101 SRSNQKSASCSNENHFTSRP ARFIARQNAS SAFKTCTPSP RKILALVCA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 089 shows 88.6% identity over a 149 aa overlap with a predicted ORF(ORF 089.ng) from N. gonorrhoeae:

m089/g089         10        20        30        40        50        60m089.pep MPPKITXSGFCKPAIAAAVAPTFVPLLSSINTTPFFSPIFSTRCGRPWKVLTCSSNASRD|||||| ||||||||||||||||||||||:|||||||||||||||:||||||||||||| g089MPPKITKSGFCKPAIAAAVAPTFVPLLSSMNTTPFFSPIFSTRCGKPWKVLTCSSNASRG        10        20        30        40        50        60        70        80        90       100       110       120 m089.pepKPMASHKATAAMTLAALCXPCNGMSCVTIKSSLPCFRRPVSRSNQKSASCSNENHFTSRP|| ||||||||:|||||| ||:||||| ||||||||::|| ||||||||||:||:||||| g089KPTASHKATAAITLAALCKPCSGMSCVEIKSSLPCFKQPVPRSNQKSASCSKENRFTSRP        70        80        90       100       110       120       130       140       150 m089.pep ARFIARQNASSAFKTCTPSPRKILALVCAX|||:||||:|||||||||||||| |||||| g089 ARFMARQNTSSAFKTCTPSPRKISALVCAX       130       140       150The following partial DNA sequence was identified in N. meningitidis<SEQ ID 293>:

a089.seq 1 ATGCCGCCTA AAATCACGAA GAGCGGATTT TGCAAACCGG CAATCGCGGC 51GGCGGTCGCA CCGACGTTCG TGCCTTTGCT GTCGTCGATG AACACCACGC 101 CATTTTTCTCGCCGATTTTT TCCACGCGGT GCGGCAGGCC TTGAAAGGTT 151 TTGACGTGTT CGAGCAATGCTTCGCGCGGC AAACCGACGG CTTCGCACAA 201 GGCAACGGCA GCCATCACGT TAGTGGCGTTGTGCAAGCCT TGCAGCGGAA 251 TATCTTGCGT GGCAATCAAA TCTTCATTGC CTTGTTTCAGGCGACCTGTC 301 TCACGTTCCA ACCAAAAATC GGCTTCGTAT TCCAACGAAA ACCATTTCAC351 CTCGCGCCCG GCGCGCTTCA TCGCACGACA GAACGCATCG TCCGCATTCA 401AAACCTGCAC ACCGTCGCCA CGGAAAATCT TGGCTTTGGT ATGCGCGTAGThis corresponds to the amino acid sequence <SEQ ID 294; ORF 089.a>:

a089.pep 1 MPPKITKSGF CKPAIAAAVA PTFVPLLSSM NTTPFFSPIF STRCGRP*KV 51LTCSSNASRG KPTASHKATA AITLVALCKP CSGISCVAIK SSLPCFRRPV 101 SRSNQKSASYSNENHFTSRP ARFIARQNAS SAFKTCTPSP RKILALVCA* m089/a089 91.9% identityover a 149 aa overlap        10        20        30        40        50        60 m089.pepMPPKITXSGFCKPAIAAAVAPTFVPLLSSINTTPFFSPIFSTRCGRPWKVLTCSSNASRD|||||| ||||||||||||||||||||||:||||||||||||||||| ||||||||||| a089MPPKITKSGFCKPAIAAAVAPTFVPLLSSMNTTPFFSPIFSTRCGRPXKVLTCSSNASRG        10        20        30        40        50        60        70        80        90       100       110       120 m089.pepKPMASHKATAAMTLAALCXPCNGMSCVTIKSSLPCFRRPVSRSNQKSASCSNENHFTSRP|| ||||||||:||:||| ||:|:|||:||||||||||||||||||||| |||||||||| a089KPTASHKATAAITLVALCKPCSGISCVAIKSSLPCFRRPVSRSNQKSASYSNENHFTSRP        70        80        90       100       110       120       130       140       150 m089.pep ARFIARQNASSAFKTCTPSPRKILALVCAX|||||||||||||||||||||||||||||| a089 ARFIARQNASSAFKTCTPSPRKILALVCAX       130       140       150The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 295>:

g090.seq 1 ATGCGCGTAG TCGAGCAAAT CGTCGTAGCG GTCGAGATGG TCTTCGGAAA 51TGTTCATCAC CGTCGCCGCA GTCGGGCGCA GGCTTTCGGT GTTTTCCAGT 101 TGGAAGCTGGAAAGCTCcca CACCCACACG TCCGCCTTTT TGCCTTCgcg 151 ctgCAATtct gcctccaagacgggcgtacc gatATTGCCC GCAATGAcgg 201 tatccagccc gcacttgatg CAGAGatagcggaccaggct ggttaccgTG 251 GTTttgccgt tgctgCcggt aatcgCaatc accttgtcgCCGCGGCGGtt 301 cAcaaTGTCc gccaGCAATt ggATGTCGCC TAgCACGCGC .ccgccgTTT351 TGCttgaThis corresponds to the amino acid sequence <SEQ ID 296; ORF 090.ng>:

g090.pep 1 MRVVEQIVVA VEMVFGNVHH RRRSRAQAFG VFQLEAGKLP HPHVRLFAFA 51LQFCLQDGRT DIARNDGIQP ALDAEIADQA GYRGFAVAAG NRNHLVAAAV 101 HNVRQQLDVAXHAXRRFA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 297>:

m090.seq 1 ATGCGCATAG TCGAGCAAGT CGTCGTAGCG GTCGAGATGG TCTTCGGAAA 51TGTTCAGCAC CGTCGCCGCA GTCGGACGCA GGCTTTCGGT GTTTTCCAGT 101 TGGAAGCTGGAAAGCTCCAA CACCCACACG TCCGCCTTTT TGCCTTCGCG 151 CTGCCATTCC GCCTCCAAAACCGGCGTGCC GATATTGCCC GCGATAACGG 201 TATCCAGCCC GCACTTGATA CAGAGATAGCCGACCAGGCT CGTTACCGTG 251 GTTTTGCCGT TGCTGCCGGT AATCGCAATT ACCTTGTCGTCCCGGCGGTT 301 CACAATGTCC GCCAGCAATT CGATGTCGCC CAACACGCGT .CCGCCGTTT351 TGCTTGAThis corresponds to the amino acid sequence <SEQ ID 298; ORF 090>:

m090.pep 1 MRIVEQVVVA VEMVFGNVQH RRRSRTQAFG VFQLEAGKLQ HPHVRLFAFA 51LPFRLQNRRA DIARDNGIQP ALDTEIADQA RYRGFAVAAG NRNYLVVPAV 101 HNVRQQFDVAQHAXRRFA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 090 shows 83.9% identity over a 118 aa overlap with a predicted ORF(ORF 090.ng) from N. gonorrhoeae:

m090/g090         10        20        30        40        50        60m090.pep MRIVEQVVVAVEMVFGNVQHRRRSRTQAFGVFQLEAGKLQHPHVRLFAFALPFRLQNRRA||:|||:|||||||||||:||||||:||||||||||||| ||||||||||| | ||: |: g090MRVVEQIVVAVEMVFGNVHHRRRSRAQAFGVFQLEAGKLPHPHVRLFAFALQFCLQDGRT        10        20        30        40        50        60        70        80        90       100       110      119 m090.pepDIARDNGIQPALDTEIADQARYRGFAVAAGNRNYLVVPAVHNVRQQFDVAQHAXRRFAX||||::|||||||:|||||| |||||||||||||:||: ||||||||:||| |||||||| g090DIARNDGIQPALDAEIADQAGYRGFAVAAGNRNHLVAAAVHNVRQQLDVAXHAXRRFAX        70        80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 299>:

a090.seq 1 ATGCGCGTAG TCGAGCAAGT CGTCGTAGCG GTCGAGATGG TCTTCGGAAA 51TGTTCAGCAC TGTCGCCGCA GTCGGGCGCA GGCTTTCGGT GTTTTCCAGT 101 TGGAAACTGGAAAGCTCCAA CACCCACACG TCCGCCTTTT TGCCTTCGCG 151 CTGCAATTCC GCCTCCAAAACCGGCGCGCC GATATTGCCC GCGATAACGG 201 TATCCAGCCC ACACTTGATG CAGAGATAGCCGACCAGGCT CGTTACCGTG 251 GTTTTGCCGT TGCTGCCGGT AATCGCAATC ACCTTGTCGCCGCGGCGGTT 301 CACAATGTCC GCCAGCAATT CGATGTCGCC CAACACGCGT C.CGCCGTTT351 CGCTTAAThis corresponds to the amino acid sequence <SEQ ID 300; ORF 090.a>:

a090.pep 1 MRVVEQVVVA VEMVFGNVQH CRRSRAQAFG VFQLETGKLQ HPHVRLFAFA 51LQFRLQNRRA DIARDNGIQP TLDAEIADQA RYRGFAVAAG NRNHLVAAAV 101 HNVRQQFDVAQHAXRRFA* m09/a090 91.5% identity over a 117 aa overlap        10        20        30        40        50        60 m090.pepMRIVEQVVVAVEMVFGNVQHRRRSRTQAFGVFQLEAGKLQHPHVRLFAFALPFRLQNRRA||:||||||||||||||||| ||||:|||||||||:||||||||||||||| |||||||| a090MRVVEQVVVAVEMVFGNVQHCRRSRAQAFGVFQLETGKLQHPHVRLFAFALQFRLQNRRA        10        20        30        40        50        60        70        80        90       100       110      119 m090.pepDIARDNGIQPALDTEIADQARYRGFAVAAGNRNYLVVPAVHNVRQQFDVAQHAXRRFAX||||||||||:||:|||||||||||||||||||:||: ||||||||||||||||||||| a090DIARDNGIQPTLDAEIADQARYRGFAVAAGNRNHLVAAAVHNVRQQFDVAQHAXRRFAX        70        80        90       100       110The following partial DNA sequence was identified in N. gonorrhoeaeg090-1.seq This sequence contains multiple stop codons (not shown)This corresponds to the amino acid sequence <ORF 090-1.ng>:g090-1.pep (not shown)The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2>:

m090-1.seq 1 ATGACGGCGT TTGCATTTCA GACGGCATCA CAAAGCCTTA AACGCTTCGA 51TAAACACTTC CGAACGGTGC GCGTAGCCTT TGAACATATC AAAGCTCGCG 101 CAGGCGGGGCTGAGCAACAC AATATCGCCT GCTTCGGCTT GGGCATATGC 151 CGTCTGAACG GCTTCTCCCAAAGTGGCGCA GTCGGTCATA TTCAAGCCGC 201 AGCCGTCCAA ATCGCGGCGG ATTTGCGGCGCATCGACACC AATCAAGAAC 251 ACGCCTTTTG CCTTGCCTAC CAGTGCATCG CGCAGGGGCGTGAAGTCCTG 301 CCCTTTACCC ATGCCGCCCA AAATCACGAA GAGCGGATTT TGCAAACCGG351 CAATCGCGGC GGCAGTCGCG CCGACATTCG TGCCTTTGCT GTCGTCGATA 401AACACCACGC CGTTTTTCTC GCCGATTTTT TCCACGCGGT GCGGCAGGCC 451 TTGGAAGGTTTTGACGTGTT CGAGCAATGC TTCGCGCGAC AAACCGATGG 501 CCTCACACAA AGCCACGGCAGCCATGACGT TAGCGGCGTT GTGCAGACCT 551 TGCAACGGAA TGTCTTGCGT GACAATCAAATCTTCATTGC CTTGTTTCAG 601 GCGGCCTGTC TCGCGTTCCA ACCAGAAATC AGCTTCGTGTTCCAACGAAA 651 ACCATTTTAC CTCGCGCCCG GCACGCTTCA TCGCGCGGCA GAACGCATCG701 TCCGCATTCA AAACCTGCAC GCCGTCGCCA CGGAAAATCT TGGCTTTGGT 751ATGCGCATAG TCGAGCAAGT CGTCGTAGCG GTCGAGATGG TCTTCGGAAA 801 TGTTCAGCACCGTCGCCGCA GTCGGACGCA GGCTTTCGGT GTTTTCCAGT 851 TGGAAGCTGG AAAGCTCCAACACCCACACG TCCGCCTTTT TGCCTTCGCG 901 CTGCCATTCC GCCTCCAAAA CCGGCGTGCCGATATTGCCC GCGATAACGG 951 TATCCAGCCC GCACTTGATA CAGAGATAGC CGACCAGGCTCGTTACCGTG 1001 GTTTTGCCGT TGCTGCCGGT AATCGCAATT ACCTTGTCGT CCCGGCGGTT1051 CACAATGTCC GCCAGCAATT CGATGTCGCC CAACACGCGT CCGCCGTTTT 1101GCTTGAACGC CTCAATATCC GGCTGCCGCT CGCTGATGCC GGGACTGAGA 1151 GCCAGAATATCGAAACCGTT GTCCAGCGCA TCTTTCAGAC GGCCCGTGTA 1201 AAACACCAAC CCGTCAAACATCTTACCGAT TTGCGACACG CGTTCCGGCT 1251 TCAGCTCCGC ATCATACGCA GCAACCTCCGCGCCGTTTTT GCGCAGGTAG 1301 GCAATCATGG AAATACCCGT ACCGCCGAGT CCGGCGACGAGGATTTTTTT 1351 GTTTTGAAAA GTCATTTTGG TTTGTCCTAAThis corresponds to the amino acid sequence <SEQ ID 3; ORF 090-1>:

m090-1.pep 1 MTAFAFQTAS QSLKRFDKHF RTVRVAFEHI KARAGGAEQH NIACFGLGIC 51RLNGFSQSGA VGHIQAAAVQ IAADLRRIDT NQEHAFCLAY QCIAQGREVL 101 PFTHAAQNHEERILQTGNRG GSRADIRAFA VVDKHHAVFL ADFFHAVRQA 151 LEGFDVFEQC FARQTDGLTQSHGSHDVSGV VQTLQRNVLR DNQIFIALFQ 201 AACLAFQPEI SFVFQRKPFY LAPGTLHRAAERIVRIQNLH AVATENLGFG 251 MRIVEQVVVA VEMVFGNVQH RRRSRTQAFG VFQLEAGKLQHPHVRLFAFA 301 LPFRLQNRRA DIARDNGIQP ALDTEIADQA RYRGFAVAAG NRNYLVVPAV351 HNVRQQFDVA QHASAVLLER LNIRLPLADA GTESQNIETV VQRIFQTARV 401KHQPVKHLTD LRHAFRLQLR IIRSNLRAVF AQVGNHGNTR TAESGDEDFF 451 VLKSHFGLS*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 303>:

g091.seq 1 ATGGAAATAC CCGTGCCGCC AAGTCCGGCG ACGAGGATTT TTTTGTTTGA 51AAGTCATTTT GGTTTTGTCC TAAAACAAAT CATATTGGGC AGGAGACGTC 101 CGCCCTTGCCCAAGCCGCTT TCAGACGGCA TCGCGAGCCG ATTAATAACC 151 CGCCTTCAGG CGTTGGTCATTGTCGCAGCT GTTTTGGTCT CCGTTTTGAC 201 AAGCCTTGCC AAGCCATTGT TGAGCGAGCGCAAGGTCTTG GCGCACGCCG 251 CGTCCATCGT AATACATCAA GCCCAAATTG TATTGGGCTTGGGCATCCCC 301 TTGTTCTGAThis corresponds to the amino acid sequence <SEQ ID 304; ORF 091.ng>:

g091.pep 1 MEIPVPPSPA TRIFLFESHF GFVLKQIILG RRRPPLPKPL SDGIASRLIT 51RLQALVIVAA VLVSVLTSLA KPLLSERKVL AHAASIVIHQ AQIVLGLGIP 101 LF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 305>:

m091.seq 1 ATGGAAATAC CCGTACCGCC GAGTCCGGCG ACGAGGATTT TTTTGTTTGA 51AAAGTCATTT TGGTTTGTCC TAAAACAAAT CATATTGAGC AGGAGATGTC 101 CGCCCCTGCCCAAGCCGCTT TCAGACGGCA TCGCGAGCTG TTCAATAACC 151 CGCCTTCAGG CGTTGGTCATTGTCGCAGCC GTCTTGGTCT CCGTTTTGAC 201 AAGCCTTGCC AAACCATTCT TGTGCAAGGGCGCGGTCTTG GCGCACGCCG 251 CGTCTTTCGG CATACATCAC GCCCAAATTG TTTTGGGCTTGGGCTACCCC 301 CTGCGC...This corresponds to the amino acid sequence <SEQ ID 306; ORF 091>:

m091.pep 1 MEIPVPPSPA TRIFLFEKSF WFVLKQIILS RRCPPLPKPL SDGIASCSIT 51RLQALVIVAA VLVSVLTSLA KPFLCKGAVL AHAASFGIHH AQIVLGLGYP 101 LR.Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 091 shows 84.2% identity over a 101 aa overlap with a predicted ORF(ORF 091.ng) from N. gonorrhoeae:

m091/g091         10        20        30        40        50        60m091.pep MEIPVPPSPATRIFLFEKSFWFVLKQIILSRRCPPLPKPLSDGIASCSITRLQALVIVAA|||||||||||||||||: | ||||||||:|| |||||||||||||  |||||||||||| g091MEIPVPPSPATRIFLFESHFGFVLKQIILGRRRPPLPKPLSDGIASRLITRLQALVIVAA        10        20        30        40        50        60        70        80        90       100 m091.pepVLVSVLTSLAKPFLCKGAVLAHAASFGIHHAQIVLGLGYPLR ||||||||||||:| :  |||||||:||:|||||||| || g091 VLVSVLTSLAKPLLSERKVLAHAASIVIHQAQIVLGLGIPLFX        70        80        90       100The following partial DNA sequence was identified in N. meningiditis<SEQ ID 307>:

a091.seq 1 ATGGAAATAC CCGTGCCGCC AAGTCCGGCG ACGAGGATTT TTTTGTTTTG 51GAAATCATTT TGGTTTGTCC TAAAACAAAT CATATTGAGC AGGGGATGTC 101 TGATCCTGCTCAAGCCGCTT TCAGACGGCA TCGCGAGCTG TTCAATAACC 151 CGCTTTCAGG CGTTGGTCATTGTCGCAGCT GTCTTGGTAT CCGTTTTGAC 201 AAGCCTTGCC AAGCCATTCT TGTGCAAGGGCGCGGTCTTG GCGCACGCCG 251 CGTCTTTCGG CATACATCAC GCCCAAATTG TTTTGGGCThis corresponds to the amino acid sequence <SEQ ID 308; ORF 091.a>:

a091.pep 1 MEIPVPPSPA TRIFLFWKSF WFVLKQIILS RGCLILLKPL SDGIASCSIT 51RFQALVIVAA VLVSVLTSLA KPFLCKGAVL AHAASFGIHH AQIVLG m091/a091 93.8%identity over a 96 aa overlap        10        20        30        40        50        60 m091.pepMEIPVPPSPATRIFLFEKSFWFVLKQIILSRRCPPLPKPLSDGIASCSITRLQALVIVAA|||||||||||||||| |||||||||||||| |  | ||||||||||||||:|||||||| a091MEIPVPPSPATRIFLFWKSFWFVLKQIILSRGCLILLKPLSDGIASCSITRFQALVIVAA        10        20        30        40        50        60        70        80        90       100 m091.pepVLVSVLTSLAKPFLCKGAVLAHAASFGIHHAQIVLGLGYPLR|||||||||||||||||||||||||||||||||||| a091VLVSVLTSLAKPFLCKGAVLAHAASFGIHHAQIVLG         70        80        90The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 309>:

g092.seq 1 ATGTTTTTTA TTTCAATCCG CTATATATTT GTCAGAAAAC TATGGTGCGC 51AAACGGTCAG ACCTTTAAAA TAACGCCTTT ACGCACTAAA AACCAACCGG 101 AACGCAACATTATGATGAAA AATCGAGTAA GCAACATCCA TTTTGTCGGT 151 ATCGGCGGCG TCGGCATGAGCGGTATCGCC GAAGTCTTGC ACAATTTGGG 201 CTTTAAAGTT TCCGGTTCGG ATCAGGCGCGAAATGCCGCT ACCGAGCATT 251 TGAGCAGCCT GGGCATTCAA GTTTATCCCG GCCATACCGCAGAACACGTT 301 AACGGTgcgg ATGTCGTCGT TGCCTCTACC GCCGTCAAGA AAGAAaatcC351 CGAAGTtgtc gcTGCGTTGG AGCGGCAAAT TCCCGTTATT CCGCGCGCCT 401TGATGCTGGC AGAGCTGATG CGCTTCCGTG ACGgcatcgc cattgccggT 451 ACGCACGGCAAAACCACGAC CACCAGCCTG ACCGCCTCCA TCCTCGGCGC 501 GGCAGGACTC GACCCCACTTTCGTTATCGG CGGCAAACTC AACGCCGCAG 551 GCACCAACGC CCGCTTGGGC AAAGGCGAATACATCGTTGC CGAAGCCGAC 601 GAATCCGATG CCTCTTTCCT ACATCTGACC CCGATTATGTCCGTCGTTAC 651 CAATATCGAC GAAGACCATA TGGATACCTA CGGGCACAGC GTCGAAAAAC701 TGCATCAGGC GTTTATCGAT TTCATCCACC GTATGCCCTT CTACGGCAAA 751GCCTTTTTGT GTGTTGACAG CGAACACGTC CGCGCGATTT TGCCCAAAGT 801 GAGCAAACCTTATGCTACTT ACGGTTTGGA CGATACCGCC GACATCTACG 851 CCACCGACAT CGAAAACGTCGGCGCGCAAA TGAAATTCAC CGTCCATGTT 901 CAAATGAAAG GACATGAGCA GGGGTCGTTTGAAGTCGTGC TGAATATGCC 951 CGGCAGACAC AACGTGCTGA ACGCATTGGC AGCCATCGGcgtggcGCTgg 1001 aagtcGgCGC ATcggttgAA GCGAtcCAAA AaggCTTGCT CGGCTTTGAA1051 GGCGTCGGCC GCCGCTTCCA AAAATAcggc gacatCAagt tgccaaacgg 1101cggGaccgCT TTgctGGTGG ACGATTAcgg ACACCACCCC GTCGAAATGG 1151 CGGcaacccttgccgcTGCA CGCGGCGCGT ATCCGGAAAA acgtTTGGTG 1201 CtcgCCTTCC AGCCGCACCGCTATACCCGC ACGCGCGATT TGTTTGAAGA 1251 CTTTACCAAA GTACTCAATA CCGTTGatgCGCTGGTACTG ACCGAAGTTT 1301 AtgccgccgG CGAAGAGCCG GTTGCCGCCG CCGactcCCGCGCCTTGGCG 1351 CGTGCTATCC GCGTATTGGG CAAACTTGAG CCGATTTACT GCGAAAatgt1401 cgccgACCTG CCGCAAATGC TGATGAATGT TTTACAGGAT Ggcgatgttg 1451tgttgAATAT GggTgcggga agcatcaacc gcgttccttc cgcgctgttg 1501 gaattgtcgaAACAGAtttg AThis corresponds to the amino acid sequence <SEQ ID 310; ORF 092.ng>:

g092.pep 1 MFFISIRYIF VRKLWCANGQ TFKITPLRTK NQPERNIMMK NRVSNIHFVG 51IGGVGMSGIA EVLHNLGFKV SGSDQARNAA TEHLSSLGIQ VYPGHTAEHV 101 NGADVVVASTAVKKENPEVV AALERQIPVI PRALMLAELM RFRDGIAIAG 151 THGKTTTTSL TASILGAAGLDPTFVIGGKL NAAGTNARLG KGEYIVAEAD 201 ESDASFLHLT PIMSVVTNID EDHMDTYGHSVEKLHQAFID FIHRMPFYGK 251 AFLCVDSEHV RAILPKVSKP YATYGLDDTA DIYATDIENVGAQMKFTVHV 301 QMKGHEQGSF EVVLNMPGRH NVLNALAAIG VALEVGASVE AIQKGLLGFE351 GVGRRFQKYG DIKLPNGGTA LLVDDYGHHP VEMAATLAAA RGAYPEKRLV 401LAFQPHRYTR TRDLFEDFTK VLNTVDALVL TEVYAAGEEP VAAADSRALA 451 RAIRVLGKLEPIYCENVADL PQMLMNVLQD GDVVLNMGAG SINRVPSALL 501 ELSKQI*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 311>:

m092.seq 1 ATGTTTTTTA TTTCAATCCG CTATATATTT GTCAGAAAAC TATGGCGCGC 51AAACGGTCAG CCCTTTAAAA TAACGCCTTT ACGCATCGAA AATCCACCGG 101 AACGCAACATTATGATGAAA AATCGAGTTA CCAACATCCA TTTTGTCGGT 151 ATCGGCGGCG TCGGCATGAGCGGCATCGCC GAAGTCTTGC ACAATTTGGG 201 CTTTAAAGTT TCCGGTTCGG ATCAgGCGCGAAATGCCGCT ACCGAGCATT 251 TGGGCAGCCT GGGCATTCAA GTTTATCCCG GCCATACCGCCGAACACGTT 301 AACGGTGCGG ATGTCGTCGT TACCTCTACC GCCGTCAAAA AAGAAAATCC351 CGAAGTTGTC GCTGCGTTGG AGCAGCAAAT TCCCGTTATT CCGCGCGCCC 401TGATGTTGGC GGAGTTGATG CGCTTCCGTG ACGGCATCGC CATTGCCGGC 451 ACGCACGGCAAAACCACGAC CACCAGCCTG ACCGCCTCCA TCCTCGGCGC 501 GGCAGGACTT GACCCGACTTTCGTTATCGG CGGCAAACTC AACGCCGCAG 551 GCACTAACGC CCGCTTGGGC AAAGGCGAATACATCGTTGC CGAAGCCGAC 601 GAGTCGGATG CATCCTTTCT GCACCTGACA CCGATTATGTCCGTCGTTAC 651 CAATATCGAC GAAGACCATA TGGATACCTA CGGGCACAGC GTCGAAAAAC701 TGCATCAGGC GTTTATCGAT TTCATCCACC GTATGCCCTT CTACGGCAAA 751GCCTTTTTGT GTATTGACAG CGAACACGTC CGCGCGATTT TGCCCAAAGT 801 GAGCAAACCTTATGCTACTT ACGGTTTGGA CGATACCGCC GACATCTACG 851 CCACCGACAT CGAAAACGTCGGCGCGCAAA TGAAATTCAC CGTCCATGTT 901 CAAATGAAAG GACATGAGCA GGGGTCGTTTGAAGTCGTGC TGAATATGCC 951 CGGCAGACAC AACGTGCTGA ACGCATTGGC AGCCATCGGCGTGGCGCTGG 1001 AAGTCGGCGC ATCGGTTGAA GCGATCCAAA AAGGCTTGCT CGGCTTTGAA1051 GGCGTCGGCC GCCGCTTCCA AAAATACGGC GACATCAAGT TGCCAAACGG 1101CGGGACCGCG CTCTTGGTGG ACGACTACGG ACACCACCCC GTCGAAATGG 1151 CGGCGACCCTTGCCGCCGCA CGCGGCGCGT ATCTGGAAAA ACGTTTGGTA 1201 CTCGCCTTCC AGCCGCACCGCTATACCCGC ACGCGCGATT TGTTTGAAGA 1251 CTTTACCAAA GTCCTCAATA CCGTTGACGCGCTGGTGCTG ACCGAAGTTT 1301 ATGCCGCCGG TGAAGAGCCG ATTGCCGCCG CCGATTCCCGCGCTCTTGCC 1351 CGCGCCATCC GCGTGTTGGG CAAACTCGAG CCGATTTACT GCGAAAACGT1401 TGCCGATCTG CCCGAAATGC TGTTGAACGT TTTGCAGGAC GGCGACATCG 1451TGTTGAATAT GGGCGCGGGA AGCATCAACC GCGTCCCCGC CGCGCTGCTG 1501 GCATTGTCGAAACAGATTTG AThis corresponds to the amino acid sequence <SEQ ID 312; ORF 092>:

m092.pep 1 MFFISIRYIF VRKLWRANGQ PFKITPLRIE NPPERNIMMK NRVTNIHFVG 51IGGVGMSGIA EVLHNLGFKV SGSDQARNAA TEHLGSLGIQ VYPGHTAEHV 101 NGADVVVTSTAVKKENPEVV AALEQQIPVI PRALMLAELM RFRDGIAIAG 151 THGKTTTTSL TASILGAAGLDPTFVIGGKL NAAGTNARLG KGEYIVAEAD 201 ESDASFLHLT PIMSVVTNID EDHMDTYGHSVEKLHQAFID FIHRMPFYGK 251 AFLCIDSEHV RAILPKVSKP YATYGLDDTA DIYATDIENVGAQMKFTVHV 301 QMKGHEQGSF EVVLNMPGRH NVLNALAAIG VALEVGASVE AIQKGLLGFE351 GVGRRFQKYG DIKLPNGGTA LLVDDYGHHP VEMAATLAAA RGAYLEKRLV 401LAFQPHRYTR TRDLFEDFTK VLNTVDALVL TEVYAAGEEP IAAADSRALA 451 RAIRVLGKLEPIYCENVADL PEMLLNVLQD GDIVLNMGAG SINRVPAALL 501 ALSKQI*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 092 shows 96.6% identity over a 506 aa overlap with a predicted ORF(ORF 092.ng) from N. gonorrhoeae:

m092/g092         10        20        30        40        50        60m092.pep MFFISIRYIFVRKLWRANGQPFKITPLRIENPPERNIMMKNRVTNIHFVGIGGVGMSGIA||||||||||||||| |||| ||||||| :| |||||||||||:|||||||||||||||| g092MFFISIRYIFVRKLWCANGQTFKITPLRTKNQPERNIMMKNRVSNIHFVGIGGVGMSGIA        10        20        30        40        50        60        70        80        90       100       110       120 m092.pepEVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAEHVNGADVVVTSTVKKENPEVV||||||||||||||||||||||||:||||||||||||||||||||||:|||||||||||| g092EVLHNLGFKVSGSDQARNAATEHLSSLGIQVYPGHTAEHVNGADVVVASTAVKKENPEVV        70        80        90       100       110       120       130       140       150       160       170       180 m092.pepAALEQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTTSLTASILGAAGLDPTFVIGGKL||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||| g092AALERQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTTSLTASILGAAGLDPTFVIGGKL       130       140       150       160       170       180       190       200       210       220       230       240 m092.pepNAAGTNARLGKGEYIVAEADESDASFLHLTPIMSVVTNIDEDHMDTYGHSVEKLHQAFID|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g092NAAGTNARLGKGEYIVAEADESDASFLHLTPIMSVVTNIDEDHMDTYGHSVEKLHQAFID       190       200       210       220       230       240       250       260       270       280       290       300 m092.pepFIHRMPFYGKAFLCIDSEHVRAILPKVSKPYATYGLDDTADIYATDIENVGAQMKFTVHV||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||| g092FIHRMPFYGKAFLCVDSEHVRAILPKVSKPYATYGLDDTADIYATDIENVGAQMKFTVHV       250       260       270       280       290       300       310       320       330       340       350       360 m092.pepQMKGHEQGSFEVVLNMPGRHNVLNALAAIGVALEVGASVEAIQKGLLGFEGVGRRFQKYG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g092QMKGHEQGSFEVVLNMPGRHNVLNALAAIGVALEVGASVEAIQKGLLGFEGVGRRFQKYG       310       320       330       340       350       360       370       380       390       400       410       420 m092.pepDIKLPNGGTALLVDDYGHHPVEMAATLAAARGAYLEKRLVLAFQPHRYTRTRDLFEDFTK|||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||| g092DIKLPNGGTALLVDDYGHHPVEMAATLAAARGAYPEKRLVLAFQPHRYTRTRDLFEDFTK       370       380       390       400       410       420       430       440       450       460       470       480 m092.pepVLNTVDALVLTEVYAAGEEPIAAADSRALARAIRVLGKLEPIYCENVADLPEMLLNVLQD||||||||||||||||||||:||||||||||||||||||||||||||||||:||:||||| g092VLNTVDALVLTEVYAAGEEPVAAADSRALARAIRVLGKLEPIYCENVADLPQMLMNVLQD       430       440       450       460       470       480       490       500 m092.pep GDIVLNMGAGSINRVPAALLALSKQIX||:|||||||||||||:||| |||||| g092 GDVVLNMGAGSINRVPSALLELSKQIX       490       500The following partial DNA sequence was identified in N. meningitidis<SEQ ID 313>:

a092.seq 1 ATGTTTTTTA TTTCAATCCG CTATATATTT GTCAGAAAAC TATGGCGCGC 51AAACGGTCAG CCCTTTAAAA TAACGCCTTT ACGCATCGAA AATCCACCGG 101 AACGCAACATTATGATGAAA AATCGAGTGA CCAACATCCA TTTTGTCGGT 151 ATCGGCGGCG TCGGCATGAGCGGTATCGCC GAAGTCTTGC ACAATTTGGG 201 TTTTAAAGTT TCCGGTTCGG ATCAGGCGCGAAATGCCGCT ACCGAGCATT 251 TGGGCAGCCT GGGCATTCAA GTTTATCCCG GCCATACCGCAGAACACGTT 301 AACGGTGCGG ATGTCGTCGT TACCTCTACC GCCGTCAAAA AAGAAAATCC351 CGAAGTTGTC GCTGCGTTGG AGCAGCAAAT TCCCGTTATT CCGCGCGCCC 401TGATGTTGGC GGAGTTGATG CGCTTCCGTG ACGGCATCGC CATTGCCGGC 451 ACGCACGGCAAAACCACGAC CACCAGCCTG ACCGCCTCCA TCCTCGGCGC 501 GGCAGGACTT GACCCGACTTTCGTTATCGG CGGCAAACTC AACGCCGCAG 551 GCACCAACGC CCGCTTGGGC AAAGGCGAATACATCGTTGC CGAAGCCGAC 601 GAGTCGGATG CATCCTTTCT GCACCTGACA CCGATTATGTCCGTCGTTAC 651 CAATATCGAC GAAGACCATA TGGATACCTA CGGGCACAGT GTTGAGAAGC701 TGCATCAGGC GTTTATCGAT TTCATCCACC GTATGCCCTT CTACGGCAAA 751GCCTTTTTGT GTATTGACAG CGAACACGTC CGCGCGATTT TGCCCAAAGT 801 GAGCAAACCTTATGCTACTT ACGGTTTGGA CGATACCGCC GACATCTACG 851 CCACCGACAT CGAAAACGTCGGCGCGCAAA TGAAATTCAC CGTCCATGTT 901 CAAATGAAAG GACATGAGCA GGGGTCGTTTGAAGTCGTGC TGAATATGCC 951 CGGCAGACAC AACGTGCTGA ACGCATTGGC AGCCATCGGCGTGGCGCTGG 1001 AAGTCGGCGC ATCGGTTGAA GCGATCCAAA AAGGCTTGCT CGGCTTTGAA1051 GGTGTCGGCC GCCGCTTCCA AAAATACGGC GACATCAAGT TGCCAAACGG 1101TGGAACCGCG CTCTTGGTGG ACGACTACGG ACACCACCCC GTCGAAATGG 1151 CGGCGACCCTTTCCGCCGCA CGCGGCGCGT ATCCGGAAAA ACGTTTGGTA 1201 CTCGCCTTCC AGCCGCACCGCTATACCCGC ACGCGCGATT TGTTTGAAGA 1251 CTTTACCAAA GTCCTCAATA CCGTTGACGCGCTGGTGCTG ACCGAAGTTT 1301 ATGCCGCCGG TGAAGAGCCG ATTGCCGCCG CTGATTCCCGCGCTCTTGCC 1351 CGCGCCATCC GCGTGTTGGG CAAACTCGAG CCGATTTACT GCGAAAACGT1401 TGCCGATCTG CCCGAAATGC TGTTGAACGT TTTGCAGGAC GGCGACATCG 1451TGTTGAATAT GGGTGCGGGA AGCATCAACC GCGTCCCCGC CGCGCTGCTG 1501 GAATTGTCGAAACAGATTTG AThis corresponds to the amino acid sequence <SEQ ID 314; ORF 092.a>:

a092.pep 1 MFFISIRYIF VRKLWRANGQ PFKITPLRIE NPPERNIMMK NRVTNIHFVG 51IGGVGMSGIA EVLHNLGFKV SGSDQARNAA TEHLGSLGIQ VYPGHTAEHV 101 NGADVVVTSTAVKKENPEVV AALEQQIPVI PRALMLAELM RFRDGIAIAG 151 THGKTTTTSL TASILGAAGLDPTFVIGGKL NAAGTNARLG KGEYIVAEAD 201 ESDASFLHLT PIMSVVTNID EDHMDTYGHSVEKLHQAFID FIHRMPFYGK 251 AFLCIDSEHV RAILPKVSKP YATYGLDDTA DIYATDIENVGAQMKFTVHV 301 QMKGHEQGSF EVVLNMPGRH NVLNALAAIG VALEVGASVE AIQKGLLGFE351 GVGRRFQKYG DIKLPNGGTA LLVDDYGHHP VEMAATLSAA RGAYPEKRLV 401LAFQPHRYTR TRDLFEDFTK VLNTVDALVL TEVYAAGEEP IAAADSRALA 451 RAIRVLGKLEPIYCENVADL PEMLLNVLQD GDIVLNMGAG SINRVPAALL 501 ELSKQI* m092/a092 99.4%identity over a 506 aa overlap        10        20        30        40        50        60 m092.pepMFFISIRYIFVRKLWRANGQPFKITPLRIENPPERNIMMKNRVTNIHFVGIGGVGMSGIA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a092MFFISIRYIFVRKLWRANGQPFKITPLRIENPPERNIMMKNRVTNIHFVGIGGVGMSGIA        10        20        30        40        50        60        70        80        90       100       110       120 m092.pepEVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAEHVNGADVVVTSTAVKKENPEVV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a092EVLHNLGFKVSGSDQARNAATEHLGSLGIQVYPGHTAEHVNGADVVVTSTAVKKENPEVV        70        80        90       100       110       120       130       140       150       160       170       180 m092.pepAALEQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTTSLTASILGAAGLDPTFVIGGKL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a092AALEQQIPVIPRALMLAELMRFRDGIAIAGTHGKTTTTSLTASILGAAGLDPTFVIGGKL       130       140       150       160       170       180       190       200       210       220       230       240 m092.pepNAAGTNARLGKGEYIVAEADESDASFLHLTPIMSVVTNIDEDHMDTYGHSVEKLHQAFID|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a092NAAGTNARLGKGEYIVAEADESDASFLHLTPIMSVVTNIDEDHMDTYGHSVEKLHQAFID       190       200       210       220       230       240       250       260       270       280       290       300 m092.pepFIHRMPFYGKAFLCIDSEHVRAILPKVSKPYATYGLDDTADIYATDIENVGAQMKFTVHV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a092FIHRMPFYGKAFLCIDSEHVRAILPKVSKPYATYGLDDTADIYATDIENVGAQMKFTVHV       250       260       270       280       290       300       310       320       330       340       350       360 m092.pepQMKGHEQGSFEVVLNMPGRHNVLNALAAIGVALEVGASVEAIQKGLLGFEGVGRRFQKYG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a092QMKGHEQGSFEVVLNMPGRHNVLNALAAIGVALEVGASVEAIQKGLLGFEGVGRRFQKYG       310       320       330       340       350       360       370       380       390       400       410       420 m092.pepDIKLPNGGTALLVDDYGHHPVEMAATLAAARGAYLEKRLVLAFQPHRYTRTRDLFEDFTK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a092DIKLPNGGTALLVDDYGHHPVEMAATLSAARGAYPEKRLVLAFQPHRYTRTRDLFEDFTK       370       380       390       400       410       420       430       440       450       460       470       480 m092.pepVLNTVDALVLTEVYAAGEEPIAAADSRALARAIRVLGKLEPIYCENVADLPEMLLNVLQD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a092VLNTVDALVLTEVYAAGEEPIAAADSRALARAIRVLGKLEPIYCENVADLPEMLLNVLQD       430       440       450       460       470       480       490       500 m092.pep GDIVLNMGAGSINRVPAALLALSKQIX|||||||||||||||||||| |||||| a092 GDIVLNMGAGSINRVPAALLELSKQIX       490       500The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 315>:

g093.seq 1 aTGCAGAATt ttgGCAAAGT ggccgtATTG ATGGGtggtT TTTCCAGCGA 51ACGAGAaatc tcgcTGGACA GCgGTACCGC CATTTTGAAC GCCTTAAAAA 101 GCAAAGGCATAGACGCATAC GCCTTCGACC CTAAGGAAAC GCCGTTATCC 151 GAACTGAAGG AGCGGGGCTTTCAGACGGCA TTCAACATCC TTCACGGTAC 201 TTACGGCGAA GACGGGGCTG TTCAGGGTGCATTGGAACTG TTGGGCATTC 251 CCTATACCGG CAGCGGTGTC GCCGCCTCCG CCATCGGCATGGACAAATAC 301 CGCTGCAAAC TGATTTGGCA GGCATTGGGA TTACCCGTTC CCGAGTTCGC351 CGTACTGTAC GATGATACCG ATTTCGATGC CGTCGAAGAA AAATTGGGTC 401TGCCGATGTT TGTGAAGCCG GCGGCCGAAG GCAGCAGCgt cggcgtggta 451 aAAGTCAAAGAAAaaggccg TCTGAAAAGC GTTtacgaag aatTGAaaCA 501 CCTTcagggg cgaAAtcattgccgAacgTT TTATCGGCGG CGGCGAATAT 551 TCCTGCCCCG TCCTGAACGG CAAAGGGCTGCCCGGCATAC ACATCATCCC 601 CGCAACCGAG TTTTACGAct acgaagccaa GtacaaCCGAGACGAcacca 651 tttaTCAATG TCCTTCGGAA GATTTGACCG AAGCCGAAGA AAGCCTGATG701 CGCGAACTGG CGGTTCGCGG CGCACAGGCA ATCGGTGCGG AAGGCTGCGT 751GCGCGTCGAT TTCCTCAAAG ATACCGACGG CAAACTCTAT CTGTTGGAAA 801 TCAACACCCTGCCCGGTATG ACCGGCCATA GThis corresponds to the amino acid sequence <SEQ ID 316; ORF 093.ng>:

g093.pep 1 MQNFGKVAVL MGGFSSEREI SLDSGTAILN ALKSKGIDAY AFDPKETPLS 51ELKERGFQTA FNILHGTYGE DGAVQGALEL LGIPYTGSGV AASAIGMDKY 101 RCKLIWQALGLPVPEFAVLY DDTDFDAVEE KLGLPMFVKP AAEGSSVGVV 151 KVKEKGRLKS VYEELKHLQGRNHCRTFYRR RRIFLPRPER QRAARHTHHP 201 RNRVLRLRSQ VQPRRHHLSM SFGRFDRSRRKPDARTGGSR RTGNRCGRLR 251 ARRFPQRYRR QTLSVGNQHP ARYDRP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 317>:

m093.seq 1 ATGCAGAATT TTGGCAAAGT GGCCGTATTG ATGGGCGGTT TTTCCAGCGA 51ACGAGAAATC TCGCTGGACA GCGGCACCGC CATTTTGAAT GCTTTAAAAA 101 GCAAAGGCATAGACGCATAC GCCTTCGATC CTAAAGAAAC CCCATTGTCT 151 GAATTGAAGG CACAAGGTTTTCAGACGGCA TTCAACATCC TTCACGGTAC 201 TTACGGCrAA GACGGGGCGG TTCAGGGTGCATTGGAACTG TTGGGCATTC 251 CCTATACCGG CAGCGGTGTC GCCGCATCCG CCATCGGCATGGACAAATAC 301 CGCTGCAAAC TGATTTGGCA GGCATTGGGA TTGCCCGTTC CCGAGTTCGC351 CGTCCTGCAC GACGACACTG ATTTCGATGC CGTCGAAGAA AAATTGGGCC 401TGCCGATGTT TGTGAAACCG GCGGCCGAAG GCAGCAGCGT AGGCGTGGTA 451 AAAGTCAAAGGAAAAGGCCG TCTGAAAAGC GTTTACGAAG AATTGAAACA 501 CCTTCAGGG. CGAAATCATTGCCGAACGTT TTATCGGCGG CGGCGAATAT 551 TCCTGCCCCG TCCTGAACGG CAAAGGGCTGCCCGGCATAC ACATCATTCC 601 CGCAACCGAG TTTTACGACT ACGAAGCCAA GTACAACCGCGACGACACCA 651 TTTATCAATG TCCTTCGGAA GATTTGACCG AAGCCGAAGA AAGCCTGATG701 CGCGAACTGG CGGTTCGCGG CGCGCAGGCA ATCGGTGCGG AAGGCTGCGT 751GCGCGTCGAT TTCCTCAAAG ATACCGACGG CAAACTCTAT CTGTTGGAAA 801 TCAACACCCTGCCCGGTATG ACGAGCCATA GThis corresponds to the amino acid sequence <SEQ ID 318; ORF 093>:

m093.pep 1 MQNFGKVAVL MGGFSSEREI SLDSGTAILN ALKSKGIDAY AFDPKETPLS 51ELKAQGFQTA FNILHGTYGX DGAVQGALEL LGIPYTGSGV AASAIGMDKY 101 RCKLIWQALGLPVPEFAVLH DDTDFDAVEE KLGLPMFVKP AAEGSSVGVV 151 KVKGKGRLKS VYEELKHLQXRNHCRTFYRR RRIFLPRPER QRAARHTHHS 201 RNRVLRLRSQ VQPRRHHLSM SFGRFDRSRRKPDARTGGSR RAGNRCGRLR 251 ARRFPQRYRR QTLSVGNQHP ARYDEP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 093 shows 96.7% identity over a 276 aa overlap with a predicted ORF(ORF 093.ng) from N. gonorrhoeae:

m093/g093         10        20        30        40        50        60m093.pep MQNFGKVAVLMGGFSSEREISLDSGTAILNALKSKGIDAYAFDPKETPLSELKAQGFQTA||||||||||||||||||||||||||||||||||||||||||||||||||||| :||||| g093MQNFGKVAVLMGGFSSEREISLDSGTAILNALKSKGIDAYAFDPKETPLSELKERGFQTA        10        20        30        40        50        60        70        80        90       100       110       120 m093.pepFNILHGTYGXDGAVQGALELLGIPYTGSGVAASAIGMDKYRCKLIWQALGLPVPEFAVLH||||||||| |||||||||||||||||||||||||||||||||||||||||||||||||: g093FNILHGTYGEDGAVQGALELLGIPYTGSGVAASAIGMDKYRCKLIWQALGLPVPEFAVLY        70        80        90       100       110       120       130       140       150       160       170       180 m093.pepDDTDFDAVEEKLGLPMFVKPAAEGSSVGVVKVKGKGRLKSVYEELKHLQXRNHCRTFYRR||||||||||||||||||||||||||||||||| ||||||||||||||| |||||||||| g093DDTDFDAVEEKLGLPMFVKPAAEGSSVGVVKVKEKGRLKSVYEELKHLQGRNHCRTFYRR       130       140       150       160       170       180       190       200       210       220       230       240 m093.pepRRIFLPRPERQRAARHTHHSRNRVLRLRSQVQPRRHHLSMSFGRFDRSRRKPDARTGGSR||||||||||||||||||| |||||||||||||||||||||||||||||||||||||||| g093RRIFLPRPERQRAARHTHHPRNRVLRLRSQVQPRRHHLSMSFGRFDRSRRKPDARTGGSR       190       200       210       220       230       240       250       260       270 m093.pepRAGNRCGRLRARRFPQRYRRQTLSVGNQHPARYDEPX|:||||||||||||||||||||||||||||||||:|| g093RTGNRCGRLRARRFPQRYRRQTLSVGNQHPARYDRPX        250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 319>:

a093.seq 1 ATGCAGAATT TTGGCAAAGT GGCCGTATTG ATGGGCGGTT TTTCCAGCGA 51ACGAGAAATC TCGCTGGACA GCGGCACCGC CATTTTGAAT GCTTTAAAAA 101 GCAAAGGCATAGACGCATAC GCCTTCGATC CCAAGGAAAC CCCATTGTCT 151 GAATTGAAGG CACAAGGTTTTCAGACGGCA TTCAACATCC TTCACGGTAC 201 TTACGGCGAA GACGGGGCTG TTCAGGGTGCATTGGAACTG TTGGGCATTC 251 CCTATACCGG CAGCGGTGTC GCCGCATCCG CCATCGGCATGGACAAATAC 301 CGCTGCAAAC TGATTTGGCA GGCATTGGGA TTGCCCGTTC CCGAGTTCGC351 CGTCCTGCAC GACGACACTG ATTTCGATGC CGTCGAAGAA AAATTGGGCC 401TGCCGATGTT TGTGAAACCG GCGGCCGAAG GCAGCAGCGT AGGCGTGGTA 451 AAAGTCAAAGGAAAAGGCCG TCTGAAAAGC GTTTACGAAG AATTGAAACA 501 CTTTCAGGG. CGAAATCATTGCCGAACGGT TTATCGGCGG CGGCGAATAT 551 TCCTGCCCTG TGTTGAACGG CAAAGGCCTGCCCGGCATAC ACATCATCCC 601 CGCGACCGAG TTTTATGACT ACGAAGCCAA GTACAACCGCAACGACACCA 651 TTTATCAATG TCCTTCGGAA GATCTGACCG AAGCCGAAGA AAGCCTGATG701 CGCGAACTGG CGGTTCGCGG CGCGCAGGCA ATCGGTGCGG AAGGCTGCGT 751GCGCGTCGAT TTCCTCAAAG ATACCGACGG CAAACTCTAT CTGTTGGAAA 801 TCAACACCCTGCCCGGTATG ACCGGCCATA GThis corresponds to the amino acid sequence <SEQ ID 320; ORF 093.a>:

a093.pep 1 MQNFGKVAVL MGGFSSEREI SLDSGTAILN ALKSKGIDAY AFDPKETPLS 51ELKAQGFQTA FNILHGTYGE DGAVQGALEL LGIPYTGSGV AASAIGMDKY 101RCKLIWQALG LPVPEFAVLH DDTDFDAVEE KLGLPMFVKP AAEGSSVGVV 151KVKGKGRLKS VYEELKHFQX RNHCRTVYRR RRIFLPCVER QRPARHTHHP 201RDRVL*LRSQ VQPQRHHLSM SFGRSDRSRR KPDARTGGSR RAGNRCGRLR 251ARRFPQRYRR QTLSVGNQHP ARYDRP* m093/a09395.7% identity over a 276 aa overlap        10        20        30        40        50        60 m093.pepMQNFGKVAVLMGGFSSEREISLDSGTAILNALKSKGIDAYAFDPKETPLSELKAQGFQTA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a093MQNFGKVAVLMGGFSSEREISLDSGTAILNALKSKGIDAYAFDPKETPLSELKAQGFQTA        10        20        30        40        50        60        70        80        90       100       110       120 m093.pepFNILHGTYGXDGAVQGALELLGIPYTGSGVAASAIGMDKYRCKLIWQALGLPVPEFAVLH ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a093FNILHGTYGEDGAVQGALELLGIPYTGSGVAASAIGMDKYRCKLIWQALGLPVPEFAVLH        70        80        90       100       110       120       130       140       150       160       170       180 m093.pepDDTDFDAVEEKLGLPMFVKPAAEGSSVGVVKVKGKGRLKSVYEELKHLQXRNHCRTFYRR|||||||||||||||||||||||||||||||||||||||||||||||:|||||||| ||| a093DDTDFDAVEEKLGLPMFVKPAAEGSSVGVVKVKGKGRLKSVYEELKHFQXRNHCRTVYRR       130       140       150       160       170       180       190       200       210       220       230       240 m093.pepRRIFLPRPERQRAARHTHHSRNRVLRLRSQVQPRRHHLSMSFGRFDRSRRKPDARTGGSR |||||| |||| |||||| |:||| |||||||:|||||||||| ||||||||||||||| a093RRIFLPCVERQRPARHTHHPRDRVLXLRSQVQPQRHHLSMSFGRSDRSRRKPDARTGGSR       190       200       210       220       230       240       250       260       270 m093.pepRAGNRCGRLRARRFPQRYRRQTLSVGNQHPARYDEPX||||||||||||||||||||||||||||||||||:|| a093RAGNRCGRLRARRFPQRYRRQTLSVGNQHPARYDRPX        250       260       270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 321>:

g094.seq 1 ATGTATTCGC CTTTGCCCAA GCGGGCGTTG GTGCCTGCGG CGTTGAGTTT 51GCCGCCGATA ACGAAAGTGG GGTCGAGTCC TGCCGCGCCG AGGATGGAGG 101CGGTCAGGCT GGTGGTCGTG GTTTTGCCGT GCGTAccggc aatggcgatg 151cCGTCACGGA AGCGCATCAG CTCTGCCAGC ATCAAGGCGC GCGGAATAAC 201GGGAATTTGC CGCTCCAACG CAgcgacaAC TTCGGgattT TCTTTCTTGA 251CGGCGGTAGA GGCAACGACG ACATccgcAC CGTTAACGTG TTCTGCGGTA 301 TGGCCGGGAT AAThis corresponds to the amino acid sequence <SEQ ID 322; ORF 094.ng>:

g094.pep 1 MYSPLPKRAL VPAALSLPPI TKVGSSPAAP RMEAVRLVVV VLPCVPAMAM 51PSRKRISSAS IKARGITGIC RSNAATTSGF SFLTAVEATT TSAPLTCSAV 101 WPG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 323>:

m094.seq 1 ATGTATTCGC CTTTGCCCAA GCGGGCGTTA GTGCCTGCGG CGTTGAGTTT 51GCCGCCGATA ACGAAAGTCG GGTCAAGTCC TGCCGCGCCG AGGATGGAGG 101CGGTCAGGCT GGTGGTCGTG GTTTTGCCGT GCGTGCCGGC AATGGCGATG 151CCGTCACGGA AGCGCATCAA CTCCGCCAAC ATCAGGGCGC GCGGAATAAC 201GGGAATTTGC TGCTCCAACG CAGCGACAAC TTCGGGATTT TCTTTTTTGA 251CGGCGGTAGA GGTAACGACG ACATCCGCAC CGTTAACGTG TTCGGCGGTA 301 TGGCCGGGAT AAThis corresponds to the amino acid sequence <SEQ ID 324; ORF 094>:

m094.pep 1 MYSPLPKRAL VPAALSLPPI TKVGSSPAAP RMEAVRLVVV VLPCVPAMAM 51PSRKRINSAN IRARGITGIC CSNAATTSGF SFLTAVEVTT TSAPLTCSAV 101 WPG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 094 shows 95.1% identity over a 103 aa overlap with a predicted ORF(ORF 094.ng) from N. gonorrhoeae:

m094/g094         10        20        30        40        50        60m094.pep MYSPLPKRALVPAALSLPPITKVGSSPAAPRMEAVRLVVVVLPCVPAMAMPSRKRINSAN||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||: g094MYSPLPKRALVPAALSLPPITKVGSSPAAPRMEAVRLVVVVLPCVPAMAMPSRKRISSAS        10        20        30        40        50        60        70        80        90       100 m094.pepIRARGITGICCSNAATTSGFSFLTAVEVTTTSAPLTCSAVWPGX |:||||||||||||||||||||||||:|||||||||||||||| g094IKARGITGICRSNAATTSGFSFLTAVEATTTSAPLTCSAVWPGX        70        80        90       100The following partial DNA sequence was identified in N. meningitidis<SEQ ID 325>:

a094.seq 1 ATGTATTCGC CTTTGCCCAA GCGGGCGTTG GTGCCTGCGG CGTTGAGTTT 51GCCGCCGATA ACGAAAGTCG GGTCAAGTCC TGCCGCGCCG AGGATGGAGG 101CGGTCAGGCT GGTGGTCGTG GTTTTGCCGT GCGTGCCGGC AATGGCGATG 151CCGTCACGGA AGCGCATCAA CTCCGCCAAC ATCAGGGCGC GCGGAATAAC 201GGGAATTTGC TGCTCCAACG CAGCGACAAC TTCGGGATTT TCTTTTTTGA 251CGGCGGTAGA GGTAACGACG ACATCCGCAC CGTTAACGTG TTCTGCGGTA 301 TGGCCGGGAT AAThis corresponds to the amino acid sequence <SEQ ID 326; ORF 094.a>:

a094.pep 1 MYSPLPKRAL VPAALSLPPI TKVGSSPAAP RMEAVRLVVV VLPCVPAMAM 51PSRKRINSAN IRARGITGIC CSNAATTSGF SFLTAVEVTT TSAPLTCSAV 101 WPG*m094/a094 100.0% identity over a 103 aa overlap        10        20        30        40        50        60 m094.pepMYSPLPKRALVPAALSLPPITKVGSSPAAPRMEAVRLVVVVLPCVPAMAMPSRKRINSAN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a094MYSPLPKRALVPAALSLPPITKVGSSPAAPRMEAVRLVVVVLPCVPAMAMPSRKRINSAN        10        20        30        40        50        60        70        80        90       100 m094.pepIRARGITGICCSNAATTSGFSFLTAVEVTTTSAPLTCSAVWPGX|||||||||||||||||||||||||||||||||||||||||||| a094IRARGITGICCSNAATTSGFSFLTAVEVTTTSAPLTCSAVWPGX        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 327>:

g095.seq 1 ATGTCCTTTC ATTTGAACAT GGACGGTGAA TTTCATTTGC GCGCCGACGT 51TTTCGATGTC GGTGGCGTAG ATGTCGGCGG TATCGTCCAA ACCGTAAGTA 101GCATAAGGTT TGCTCACTTT GGGCAAAATC GCGCGGACGT GTTCGCTGTC 151AACACACAAA AAGGCTTTGC CGTAGAAGGG CATACGGTGG ATGAAATCGA 201TAAACGCCTG ATGCAGTTTT TCGACGCTGT GCCCGTAGGT ATCCATATGG 251TCTTCGTCGA TATTGGTAAC GACGGACATA ATCGGGGTCA GTGTAGGAAA 301GAGGCATCGG ATCGTCGGCT TCGGCAACGA TGTATTCGCC TTTGCCCAAG 351CGGGCGTTGG TGCCTGCGGC GTTGAThis corresponds to the amino acid sequence <SEQ ID 328; ORF 095.ng>:

g095.pep 1 MSFHLNMDGE FHLRADVFDV GGVDVGGIVQ TVSSIRFAHF GQNRADVFAV 51NTQKGFAVEG HTVDEIDKRL MQFFDAVPVG IHMVFVDIGN DGHNRGQCRK 101EASDRRLRQR CIRLCPSGRW CLRR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 329>:

m095.seq 1 ATGTCCTTTC ATTTGAACAT GGACGGTGAA TTTCATTTGC GCGCCGACGT 51TTTCGATGTC GGTGGCGTAG ATGTCGGCGG TATCGTCCAA ACCGTAAGTA 101GCATAAGGTT TGCTCACTTT GGGCAAAATC GCGCGGACGT GTTCGCTGTC 151AATACACAAA AAGGCTTTGC CGTAGAAGGG CATACGGTGG ATGAAATCGA 201TAAACGCCTG ATGCAGTTTT TCGACGCTGT GCCCGTAGGT ATCCATATGG 251TCTTCGTCGA TATTGGTAAC GACGGACATA ATCGGTGTCA GTGCAGAAAG 301GATGCATCCG ACCGTCGGCT TCGGCAACGA TGTATTCGCC TTTGCCCAAG 351CGGGCGTTAG TGCCTGCGGC GTTGAThis corresponds to the amino acid sequence <SEQ ID 330; ORF 095>:

m095.pep 1 MSFHLNMDGE FHLRADVFDV GGVDVGGIVQ TVSSIRFAHF GQNRADVFAV 51NTQKGFAVEG HTVDEIDKRL MQFFDAVPVG IHMVFVDIGN DGHNRCQCRK 101DASDRRLRQR CIRLCPSGRX CLRR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 095 shows 97.6% identity over a 124 aa overlap with a predicted ORF(ORF 095.ng) from N. gonorrhoeae:

m095/g095         10        20        30        40        50        60m095.pep MSFHLNMDGEFHLRADVFDVGGVDVGGIVQTVSSIRFAHFGQNRADVFAVNTQKGFAVEG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g095MSFHLNMDGEFHLRADVFDVGGVDVGGIVQTVSSIRFAHFGQNRADVFAVNTQKGFAVEG        10        20        30        40        50        60        70        80        90       100       110       120 m095.pepHTVDEIDKRLMQFFDAVPVGIHMVFVDIGNDGHNRCQCRKDASDRRLRQRCIRLCPSGRX||||||||||||||||||||||||||||||||||| ||||:|||||||||||||||||| g095HTVDEIDKRLMQFFDAVPVGIHMVFVDIGNDGHNRGQCRKEASDRRLRQRCIRLCPSGRW        70        80        90       100       110       120 m095.pepCLRRX ||||| g095 CLRRXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 331>:

a095.seq 1 ATGTCCTTTC ATTTGAACAT GGACGGTGAA TTTCATTTGC GCGCCGACGT 51TTTCGATGTC GGTGGCGTAG ATGTCGGCGG TATCGTCCAA ACCGTAAGTA 101GCATAAGGTT TGCTCACTTT GGGCAAAATC GCGCGGACGT GTTCGCTGTC 151AATACACAAA AAGGCTTTGC CGTAGAAGGG CATACGGTGG ATGAAATCGA 201TAAACGCCTG ATGCAGCTTC TCAACACTGT GCCCGTAGGT ATCCATATGG 251TCTTCGTCGA TATTGGTAAC GACGGACATA ATCGGTGTCA GTGCAGAAAG 301GATGCATCCG ACCGTCGGCT TCGGCAACGA TGTATTCGCC TTTGCCCAAG 351CGGGCGTTGG TGCCTGCGGC GTTGAThis corresponds to the amino acid sequence <SEQ ID 332; ORF 095.a>:

a095.pep 1 MSFHLNMDGE FHLRADVFDV GGVDVGGIVQ TVSSIRFAHF GQNRADVFAV 51NTQKGFAVEG HTVDEIDKRL MQLLNTVPVG IHMVFVDIGN DGHNRCQCRK 101DASDRRLRQR CIRLCPSGRW CLRR* m095/a095 96.0% identity in 124 aa overlap        10        20        30        40        50        60 m095.pepMSFHLNMDGEFHLRADVFDVGGVDVGGIVQTVSSIRFAHFGQNRADVFAVNTQKGFAVEG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a095MSFHLNMDGEFHLRADVFDVGGVDVGGIVQTVSSIRFAHFGQNRADVFAVNTQKGFAVEG        10        20        30        40        50        60        70        80        90       100       110       120 m095.pepHTVDEIDKRLMQFFDAVPVGIHMVFVDIGNDGHNRCQCRKDASDRRLRQRCIRLCPSGRX||||||||||||::::||||||||||||||||||||||||||||||||||||||||||| a095HTVDEIDKRLMQLLNTVPVGIHMVFVDIGNDGHNRCQCRKDASDRRLRQRCIRLCPSGRW        70        80        90       100       110       120 m095.pepCLRRX ||||| a095 CLRRXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 333>:

g096.seq 1 ATGGCCGGTC ATACCGGGCA GGGTGTTGAT TTCCAACAGA TAGAGTTTGC 51CGTCGGTATC TTTGAGGAAA TCGACGCGCA CGCAGCCTTC CGCACCGATT 101 GCCTGTGCGCCGCGAACCGC CAGTTCGCGC ATCAGGCTTT CTTCGGCTTC 151 GGTCAAATCT TCCGAAGGACATTGAtaaat ggtgTCGTCT CGGttgtaCt 201 tggcttcgta gTCGTAAAAC TCGGTTGCGGGGATGATGTG TATGCCGGGC 251 AGCCCTTTGC CGTTCAGGAC GGGGCAGGAA TATTCGCCGCCGCCGATAAA 301 AcgtTcggca atgaTTtcgc ccctgAAGGT GttTCAattc ttcgtaAACG351 CTTTTCAGAc ggccttTTTC TTTGAThis corresponds to the amino acid sequence <SEQ ID 334; ORF 096.ng>:

g096.pep 1 MAGHTGQGVD FQQIEFAVGI FEEIDAHAAF RTDCLCAANR QFAHQAFFGF 51GQIFRRTLIN GVVSVVLGFV VVKLGCGDDV YAGQPFAVQD GAGIFAAADK 101 TFGNDFAPEGVSILRKRFSD GLFL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 335>:

m096.seq 1 ATGGCTCGTC ATACCGGGCA GGGTGTTGAT TTCCAACAGA TAGAGTTTGC 51CGTCGGTATC TTTGAGGAAA TCGACGCGCA CGCAGCCTTC CGCACCGATT 101 GCCTGCGCGCCGCGAACCGC CAGTTCGCGC ATCAGGCTTT CTTCGGCTTC 151 GGTCAAATCT TCCGAAGGACATTGATAAAT GGTGTCGTCG CGGTTGTACT 201 TGGCTTCGTA GTCGTAAAAC TCGGTTGCGGGAATGATGTG TATGCCGGGC 251 AGCCCTTTGC CGTTCAGGAC GGGGCAGGAA TATTCGCCGCCGCCGATAAA 301 ACGTTCGGCA ATGATTTCGC CC.TGAAGGT GTTTCAATTC TTCGTAAACG351 CTTTTCAGAC GGCCTTTTCC TTTGAThis corresponds to the amino acid sequence <SEQ ID 336; ORF 096>:

m096.pep 1 MARHTGQGVD FQQIEFAVGI FEEIDAHAAF RTDCLRAANR QFAHQAFFGF 51GQIFRRTLIN GVVAVVLGFV VVKLGCGNDV YAGQPFAVQD GAGIFAAADK 101 TFGNDFAXEGVSILRKRFSD GLFL* m096/g096 96.0% identity in 124 aa overlap        10        20        30        40        50        60 m096.pepMARHTGQGVDFQQIEFAVGIFEEIDAHAAFRTDCLRAANRQFAHQAFFGFGQIFRRTLIN|| |||||||||||||||||||||||||||||||| |||||||||||||||||||||||| g096MAGHTGQGVDFQQIEFAVGIFEEIDAHAAFRTDCLCAANRQFAHQAFFGFGQIFRRTLIN        10        20        30        40        50        60        70        80        90       100       110       120 m096.pepGVVAVVLGFVVVKLGCGNDVYAGQPFAVQDGAGIFAAADKTFGNDFAXEGVSILRKRFSD|||:|||||||||||||:||||||||||||||||||||||||||||| |||||||||||| g096GVVSVVLGFVVVKLGCGDDVYAGQPFAVQDGAGIFAAADKTFGNDFAPEGVSILRKRFSD        70        80        90       100       110       120 m096.pepGLFLX ||||| g096 GLFLXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 337>:

a096.seq 1 ATGGCCGGTC ATACCGGGCA GGGTGTTGAT TTCCAACAGA TAGAGTTTGC 51CGTCGGTATC TTTGAGGAAA TCGACGCGCA CGCAGCCTTC CGCACCGATT 101 GCCTGCGCGCCGCGAACCGC CAGTTCGCGC ATCAGGCTTT CTTCGGCTTC 151 GGTCAGATCT TCCGAAGGACATTGATAAAT GGTGTCGTTG CGGTTGTACT 201 TGGCTTCGTA GTCATAAAAC TCGGTCGCGGGGATGATGTG TATGCCGGGC 251 AGGCCTTTGC CGTTCAACAC AGGGCAGGAA TATTCGCCGCCGCCGATAAA 301 CCGTTCGGCA ATGATTTCGC CCT.GAAAGT GTTTCAATTC TTCGTAAACG351 CTTTTCAGAC GGCCTTTTCC TTTGAThis corresponds to the amino acid sequence <SEQ ID 338; ORF 096.ng>:

a096.pep 1 MAGHTGQGVD FQQIEFAVGI FEEIDAHAAF RTDCLRAANR QFAHQAFFGF 51GQIFRRTLIN GVVAVVLGFV VIKLGRGDDV YAGQAFAVQH RAGIFAAADK 101 PFGNDFAXESVSILRKRFSD GLFL* m096/a096 92.7% identity in 124 aa overlap        10        20        30        40        50        60 m096.pepMARHTGQGVDFQQIEFAVGIFEEIDAHAAFRTDCLRAANRQFAHQAFFGFGQIFRRTLIN|| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a096MAGHTGQGVDFQQIEFAVGIFEEIDAHAAFRTDCLRAANRQFAHQAFFGFGQIFRRTLIN        10        20        30        40        50        60        70        80        90       100       110       120 m096.pepGVVAVVLGFVVVKLGCGNDVYAGQPFAVQDGAGIFAAADKTFGNDFAXEGVSILRKRFSD|||||||||||:||| |:|||||| ||||  ||||||||| ||||||||:|||||||||| a096GVVAVVLGFVVIKLGRGDDVYAGQAFAVQHRAGIFAAADKPFGNDFAXESVSILRKRFSD        70        80        90       100       110       120 m096.pepGLFLX ||||| a096 GLFLXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 339>:

g097.seq 1 ATGGATATTT CAAAACAAAC ATTGCTGGAT AGGGTTTTTA ACCTGAAGGC 51AAACGGTACG ACGGTACGTA CCGAGTTGAT GGCGGGTTTG ACGACCTTTT 101 TGACGATGTGCTACATCGTT ATCGTCAATC CCCTGATTTT GGGCGAGACC 151 GGAATGGATA TGGGGGCGGTATTCGTCGCT ACCTGTATCG CATCCGCCAT 201 CGGCTGTTTT GTCATGGGTT TTATCGGCAACTATCCGATT GCGCTTGCCC 251 CGGGGATGGG GCTGAATGCC TATTTCACCT TTGCCGTCGTTAAGGGTATG 301 GGCGTGCCTT GGCAGGTGGC GTTGGGTGCG GTGTTCATTT CCGGTCTGAT351 TTTCATCCTG TTCAGCTTTT TTAAAGTCAG GGAAATGCTG GTCAACGCAC 401TGCCTATGGG TTTGAAAATG TCGATTGCCG CCGGTATCGG TTTGTTTTTG 451 GCACTGATTTCCCTGAAAGG CGCAGGCATT ATCGTTGCCA ATCCGGCAAC 501 CTTGGTCGGC TTGGGCGATATTCATCAGCC CAGCGCACTG TTGGCATTGT 551 TCGGTTTTGT CATGGTGGTC GTATTGGGGTATTTCCGCGT TCAAGGCGCA 601 ATCATCATCA CCATTCTGAC GATTACCGTC ATTGCCAGCCTGATGGGTTT 651 GAACGAGTTT CACGGCGTGG TCGGCGAAGT ACCGGGCATT GCGCCGACCT701 TTATGCAGAT GGATTTTAAA GGTCTGTTTA CCGTCAGCAT GGTCAGCGTG 751ATTTTCGTCT TCTTCTTGGT CGATTTGTTC GACAGTACCG GAACGCTGGT 801 CGGCGTATCCCACCGTGCCG GACTGCTGGT GGACGGTAAG CTGCCCCGCC 851 TGAAACGCGC ACTGCTTGCAGACTCTACCG CCATTGTGGC AGGTGCGGCT 901 TTGGGTACTT CTTCAACCAC GCCTTATGTGGAAAGCGCGG CGGGCGTATC 951 GGCAGGCGGA CGGACCGGCC TGACGGCGGT TACCGTCGGCGTATTGATGC 1001 TGGCGTGTCT GATGTTCTCC CCATTGGCGA AAAGTGTTCC GGTATTTGCC1051 ACCGCGCCCG CACTGCTTTA TGTCGGCACG CAGATGCTCC GCAGTGCGAG 1101GGACATTGAT TGGGACGATA TGACTGAAGC CGCGCCCGCG TTCCTGACCA 1151 TTGTCTTCATGCCGTTTACC TATTCGATTG CAGACGGCAT CGCCTTCGGC 1201 TTCATCAGCT ATGCCGTGGTCAAACTTTTG TGTCGCCGGA CTGGGGACGT 1251 GCCGCCTATG GTATGGGTTG TTGCCGTATTGTGGGCATTG AAATTCTGGT 1301 ATTTGGGCTG AThis corresponds to the amino acid sequence <SEQ ID 340; ORF 097.ng>:

g097.pep 1 MDISKQTLLD RVFNLKANGT TVRTELMAGL TTFLTMCYIV IVNPLILGET 51GMDMGAVFVA TCIASAIGCF VMGFIGNYPI ALAPGMGLNA YFTFAVVKGM 101GVPWQVALGA VFISGLIFIL FSFFKVREML VNALPMGLKM SIAAGIGLFL 151ALISLKGAGI IVANPATLVG LGDIHQPSAL LALFGFVMVV VLGYFRVQGA 201IIITILTITV IASLMGLNEF HGVVGEVPGI APTFMQMDFK GLFTVSMVSV 251 IFVFFLVDLFDSTGTLVGVS HRAGLLVDGK LPRLKRALLA DSTAIVAGAA 301 LGTSSTTPYV ESAAGVSAGGRTGLTAVTVG VLMLACLMFS PLAKSVPVFA 351 TAPALLYVGT QMLRSARDID WDDMTEAAPAFLTIVFMPFT YSIADGIAFG 401 FISYAVVKLL CRRTGDVPPM VWVVAVLWAL KFWYLG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 341>:

m097.seq 1 ATGGACACTT CAAAACAAAC ACTGTTGGAC GGGATTTTTA AGCTGAAGGC 51AAACGGTACk ACGGTGCGTA CCGAGTTGAT GGCGGGTTTG ACAACTTTTT 101 TGACGATGTGCTACATCGTT ATCGTCAACC CTCyGATTTT GGGCGAGACC 151 GGCATGGATA TGGGGGCGGTATTCGTCGCT ACCTGTATCG CGTCTGCCAT 201 CGGCTGTTTT GTTATGGGTT TTGTCGGCAACTATCCGATT GCACTCGCAC 251 CGGGGATGGG GCTGAATGCC TATTTCACCT TTGCCGTCGTTAAGGGTATG 301 GGCGTGCCTT GGCAGGTTGC GTTGGGTGCG GTGTTCATCT CCGGTCTGAT351 TTTTATCCTG TTCAGCTTTT TTAAAGTCAG GGAAATGCTG GTCAACGCAC 401TGCCTATGGG TTTGAAAATG TCGATTGCTG CCGGTATCGG TTTGTTTTTG 451 GCACTGATTTCCCTGAAAGG CGCAGGCATT ATCGTTGCCA ATCCGGCAAC 501 CTTGGTCGGT TTGGGCGATATTCATCAGCC GTCCGCGTTG TTGGCATTGT 551 TCGGTTTTGC TATGGTGGTC GTATTGGGACATTTCCGCGT TCAAGGCGCA 601 ATCATCATCA CCATCTTGAC CATTACCGTC ATTGCCAGCCTGATGGGTTT 651 GAATGAATTT CACGGCATCA TCGGCGAAGT ACCGAGCATT GCGCCGACTT701 TTATGCAGAT GGATTTTGAA GGCCTGTTTA CCGTCAGCAT GGTCAGTGTG 751ATTTTCGTCT TCTTCTTGGT CGATCTATTT GACAGTACCG GAACGCTGGT 801 CGGCATATCCCACCGTGCCG GGCTGCTGGT GGACGGTAAG CTGCCCCGCC 851 TGAAACGCGC ACTGCTTGCAGACTCTACCG CCATTGTGGC AGGTGCGGCT 901 TTGGGTACTT CTTCCACCAC GCCTTATGTGGAAAGCGCGG CGGGCGTATC 951 GGCAGGCGGA CGGACCGGCC TGACGGCGGT TACCGTCGGCGTATTGATGC 1001 TCGCCTGCCT GATGTTTTCA CCTTTGGCGA AAAGTGTTCC CGCTTTTGCC1051 ACCGCGCCCG CCCTGCTTTA TGTCGGCACG CAGATGCTCC GCAGTGCGAG 1101GGATATTGAT TGGGACGATA TGACGGAAGC CGCACCTGCG TTCCTGACCA 1151 TTGTTTTCATGCCGTTTACT TATTCGATTG CAGACGGCAT CGCTTTCGGC 1201 TTCATCAGTT ATGCCGTGGTTAAACTTTTA TGCCGCCGCA CCAAAGACGT 1251 TCCGCCTATG GTATGGATTG TTGCCGTATTGTGGGCACTG AAATTCTGGT 1301 ATTTGGGCTG AThis corresponds to the amino acid sequence <SEQ ID 342; ORF 097>:

m097.pep 1 MDTSKQTLLD GIFKLKANGT TVRTELMAGL TTFLTMCYIV IVNPXILGET 51GMDMGAVFVA TCIASAIGCF VMGFVGNYPI ALAPGMGLNA YFTFAVVKGM 101GVPWQVALGA VFISGLIFIL FSFFKVREML VNALPMGLKM SIAAGIGLFL 151ALISLKGAGI IVANPATLVG LGDIHQPSAL LALFGFAMVV VLGHFRVQGA 201IIITILTITV IASLMGLNEF HGIIGEVPSI APTFMQMDFE GLFTVSMVSV 251 IFVFFLVDLFDSTGTLVGIS HRAGLLVDGK LPRLKRALLA DSTAIVAGAA 301 LGTSSTTPYV ESAAGVSAGGRTGLTAVTVG VLMLACLMFS PLAKSVPAFA 351 TAPALLYVGT QMLRSARDID WDDMTEAAPAFLTIVFMPFT YSIADGIAFG 401 FISYAVVKLL CRRTKDVPPM VWIVAVLWAL KFWYLG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 097 shows 96.3% identity over a 436 aa overlap with a predicted ORF(ORF 097.ng) from N. gonorrhoeae:

m097/g097         10        20        30        40        50        60m097.pep MDTSKQTLLDGIFKLKANGTTVRTELMAGLTTFLTMCYIVIVNPXILGETGMDMGAVFVA|| ||||||| :|:|||||||||||||||||||||||||||||| ||||||||||||||| g097MDISKQTLLDRVFNLKANGTTVRTELMAGLTTFLTMCYIVIVNPLILGETGMDMGAVFVA        10        20        30        40        50        60        70        80        90       100       110       120 m097.pepTCIASAIGCFVMGFVGNYPIALAPGMGLNAYFTFAVVKGMGVPWQVALGAVFISGLIFIL||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||| g097TCIASAIGCFVMGFIGNYPIALAPGMGLNAYFTFAVVKGMGVPWQVALGAVFISGLIFIL        70        80        90       100       110       120       130       140       150       160       170       180 m097.pepFSFFKVREMLVNALPMGLKMSIAAGIGLFLALISLKGAGIIVANPATLVGLGDIHQPSAL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g097FSFFKVREMLVNALPMGLKMSIAAGIGLFLALISLKGAGIIVANPATLVGLGDIHQPSAL       130       140       150       160       170       180       190       200       210       220       230       240 m097.pepLALFGFAMVVVLGHFRVQGAIIITILTITVIASLMGLNEFHGIIGEVPSIAPTFMQMDFE||||||:||||||:||||||||||||||||||||||||||||::||||:||||||||||: g097LALFGFVMVVVLGYFRVQGAIIITILTITVIASLMGLNEFHGVVGEVPGIAPTFMQMDFK       190       200       210       220       230       240       250       260       270       280       290       300 m097.pepGLFTVSMVSVIFVFFLVDLFDSTGTLVGISHRAGLLVDGKLPRLKRALLADSTAIVAGAA||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||| g097GLFTVSMVSVIFVFFLVDLFDSTGTLVGVSHRAGLLVDGKLPRLKRALLADSTAIVAGAA       250       260       270       280       290       300       310       320       330       340       350       360 m097.pepLGTSSTTPYVESAAGVSAGGRTGLTAVTVGVLMLACLMFSPLAKSVPAFATAPALLYVGT|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||| g097LGTSSTTPYVESAAGVSAGGRTGLTAVTVGVLMLACLMFSPLAKSVPVFATAPALLYVGT       310       320       330       340       350       360       370       380       390       400       410       420 m097.pepQMLRSARDIDWDDMTEAAPAFLTIVFMPFTYSIADGIAFGFISYAVVKLLCRRTKDVPPM|||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||| g097QMLRSARDIDWDDMTEAAPAFLTIVFMPFTYSIADGIAFGFISYAVVKLLCRRTGDVPPM       370       380       390       400       410       420        430m097.pep VWIVAVLWALKFWYLGX ||:|||||||||||||| g097 VWVVAVLWALKFWYLGX       430The following partial DNA sequence was identified in N. meningitidis<SEQ ID 343>

a097.seq 1 ATGGACACTT CAAAACAAAC ACTGTTGGAC GGGATTTTTA AGCTGAAGGC 51AAACGGTACG ACGGTGCGTA CCGAGTTGAT GGCGGGTTTG ACAACTTTTT 101 TGACGATGTGCTACATCGTT ATCGTCAACC CTCTGATTTT GGGCGAGACC 151 GGCATGGATA TGGGGGCGGTATTCGTCGCT ACCTGTATCG CGTCTGCCAT 201 CGGCTGTTTT GTTATGGGTT TTGTCGGCAACTATCCGATT GCACTCGCAC 251 CGGGGATGGG GCTGAATGCC TATTTCACCT TTGCCGTCGTTAAGGGTATG 301 GGCGTGCCTT GGCAGGTTGC GTTGGGTGCG GTGTTCATCT CCGGTCTGAT351 TTTCATCCTG TTCAGCTTTT TTAAAGTCAG GGAAATGCTG GTCAACGCAC 401TGCCTATGGG TTTGAAAATG TCGATTGCTG CCGGTATCGG TTTGTTTTTG 451 GCACTGATTTCCCTGAAAGG CGCAGGCATT ATCGTTGCCA ATCCGGCAAC 501 CTTGGTCGGC TTGGGCGATATTCATCAGCC GTCCGCGTTG TTGGCACTGT 551 TCGGTTTTGC CATGGTGGTC GTATTGGGACATTTCCGCGT TCAAGGCGCA 601 ATCATCATCA CCATTTTGAC GATTACCGTC ATTGCCAGCCTGATGGGTTT 651 GAACGAATTT CACGGCATCA TCGGCGAAGT GCCGAGCATT GCGCCGACTT701 TTATGCAGAT GGATTTTAAA GGGTTGTTTA CCGTCAGCAT GGTCAGCGTG 751ATTTTCGTCT TTTTCCTAGT CGATCTGTTC GACAGTACCG GAACACTGGT 801 CGGTGTATCGCATCGTGCCG GACTGCTGGT GGACGGTAAG CTGCCCCGCC 851 TGAAACGCGC ACTGCTTGCAGACTCTACCG CTATTGTGGC AGGTGCGGCT 901 TTGGGTACTT CTTCAACCAC GCCTTATGTGGAAAGTGCGG CGGGCGTATC 951 GGCAGGCGGG CGGACAGGTC TGACGGCGGT TACCGTCGGCGTATTGATGC 1001 TCGCCTGCCT GATGTTTTCA CCTTTGGCGA AAAGTGTTCC CGCTTTTGCC1051 ACCGCGCCCG CCCTGCTTTA TGTCGGCACG CAGATGCTCC GCAGTGCGAG 1101GGACATCGAT TGGGACGATA TGACGGAAGC CGCACCCGCA TTCCTGACCA 1151 TTGTCTTCATGCCGTTTACC TATTCGATTG CAGACGGCAT CGCTTTCGGC 1201 TTCATCAGTT ATGCCGTGGTTAAACTTTTA TGCCGCCGCA CCAAAGACGT 1251 TCCGCCTATG GTATGGATTG TTGCCGTATTGTGGGCACTG AAATTCTGGT 1301 ATTTGGGCTG AThis corresponds to the amino acid sequence <SEQ ID 344; ORF 097.a>:

a097.pep 1 MDTSKQTLLD GIFKLKANGT TVRTELMAGL TTFLTMCYIV IVNPLILGET 51GMDMGAVFVA TCIASAIGCF VMGFVGNYPI ALAPGMGLNA YFTFAVVKGM 101GVPWQVALGA VFISGLIFIL FSFFKVREML VNALPMGLKM SIAAGIGLFL 151ALISLKGAGI IVANPATLVG LGDIHQPSAL LALFGFAMVV VLGHFRVQGA 201IIITILTITV IASLMGLNEF HGIIGEVPSI APTFMQMDFK GLFTVSMVSV 251 IFVFFLVDLFDSTGTLVGVS HRAGLLVDGK LPRLKRALLA DSTAIVAGAA 301 LGTSSTTPYV ESAAGVSAGGRTGLTAVTVG VLMLACLMFS PLAKSVPAFA 351 TAPALLYVGT QMLRSARDID WDDMTEAAPAFLTIVFMPFT YSIADGIAFG 401 FISYAVVKLL CRRTKDVPPM VWIVAVLWAL KFWYLG*m097/a097 99.3% identity in 436 aa overlap        10        20        30        40        50        60 m097.pepMDTSKQTLLDGIFKLKANGTTVRTELMAGLTTFLTMCYIVIVNPXILGETGMDMGAVFVA|||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||| a097MDTSKQTLLDGIFKLKANGTTVRTELMAGLTTFLTMCYIVIVNPLILGETGMDMGAVFVA        10        20        30        40        50        60        70        80        90       100       110       120 m097.pepTCIASAIGCFVMGFVGNYPIALAPGMGLNAYFTFAVVKGMGVPWQVALGAVFISGLIFIL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a097TCIASAIGCFVMGFVGNYPIALAPGMGLNAYFTFAVVKGMGVPWQVALGAVFISGLIFIL        70        80        90       100       110       120       130       140       150       160       170       180 m097.pepFSFFKVREMLVNALPMGLKMSIAAGIGLFLALISLKGAGIIVANPATLVGLGDIHQPSAL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a097FSFFKVREMLVNALPMGLKMSIAAGIGLFLALISLKGAGIIVANPATLVGLGDIHQPSAL       130       140       150       160       170       180       190       200       210       220       230       240 m097.pepLALFGFAMVVVLGHFRVQGAIIITILTITVIASLMGLNEFHGIIGEVPSIAPTFMQMDFE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: a097LALFGFAMVVVLGHFRVQGAIIITILTITVIASLMGLNEFHGIIGEVPSIAPTFMQMDFK       190       200       210       220       230       240       250       260       270       280       290       300 m097.pepGLFTVSMVSVIFVFFLVDLFDSTGTLVGISHRAGLLVDGKLPRLKRALLADSTAIVAGAA||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||| a097GLFTVSMVSVIFVFFLVDLFDSTGTLVGVSHRAGLLVDGKLPRLKRALLADSTAIVAGAA       250       260       270       280       290       300       310       320       330       340       350       360 m097.pepLGTSSTTPYVESAAGVSAGGRTGLTAVTVGVLMLACLMFSPLAKSVPAFATAPALLYVGT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a097LGTSSTTPYVESAAGVSAGGRTGLTAVTVGVLMLACLMFSPLAKSVPAFATAPALLYVGT       310       320       330       340       350       360       370       380       390       400       410       420 m097.pepQMLRSARDIDWDDMTEAAPAFLTIVFMPFTYSIADGIAFGFISYAVVKLLCRRTKDVPPM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a097QMLRSARDIDWDDMTEAAPAFLTIVFMPFTYSIADGIAFGFISYAVVKLLCRRTKDVPPM       370       380       390       400       410       420        430m097.pep VWIVAVLWALKFWYLGX ||||||||||||||||| a097 VWIVAVLWALKFWYLGX       430The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 345>:

g098.seq 1 ATGACCGCCG ACGGTCTCTT CGTCGCTTTC AACTTCAATA CGTTTGCCGT 51TGTGCGAATA TTGATACCAG TACAGCAGGA TGCTGCCCAG GCTGGCGATC 101 AGTTTGTCGGCGATGTCGCG CGCTTCGCTG TCGGGATGGC TTTCGCGTTC 151 GGGATGAACG CAGCCGAGCATGGACACGCC GGTACGCATC ACGTCCATCG 201 GATGGGTATG TGCAGGCAGG CTTTCCAAAACTTTAATCAC ACGGATAGGC 251 AGGCCGCGCA TGGATTTGAG CTTGGTTTTA TAAGCGGCCAGCTCGAATTT 301 GTTGGGCAGA TGGCCGTGAA TCAGCAAGTG TGCGACTTCT TCAAACTCGC351 ATTTTTGTGC CAAATTAGAA TGTCGTAAThis corresponds to the amino acid sequence <SEQ ID 346; ORF 098.ng>:

g098.pep 1 MTADGLFVAF NFNTFAVVRI LIPVQQDAAQ AGDQFVGDVA RFAVGMAFAF 51GMNAAEHGHA GTHHVHRMGM CRQAFQNFNH TDRQAAHGFE LGFISGQLEF 101 VGQMAVNQQVCDFFKLAFLC QIRMS*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 347>:

m098.seq 1 ATGACCGCCG ATGGTCTCTT CGTCGCTTTC AACCTCAATG CGTTTGCCGT 51TGTGCGAATA TTGATACCAG TACAAGAGGA TGCTGCCGAG GCTGGCGATC 101 AGTTTGTCGGCGATGTCGCG CGCTTCACTT TCCGGATGGC TTTCACGTTC 151 AGGATGAACG CAGCCCAGCATGGATACGCC GGTACGCATT ACGTCCATCG 201 GATGGGTATG TGCAGGCAGG CTTTCCAAAACTTTAATCAC ACGGATAGGC 251 AGGCCGCGCA TGGATTTGAG CTTGGTTTTA TAAGCGGCCAGCTCGAATTT 301 GTTGGGCAGA TGGCCGTGAA TCAGCAGGTG GGCGACTTCT TCAAACTCGC351 ATTTTTGTGC CAAATCAGAA TGTCGTAAThis corresponds to the amino acid sequence <SEQ ID 348; ORF 098>:

m098.pep 1 MTADGLFVAF NLNAFAVVRI LIPVQEDAAE AGDQFVGDVA RFTFRMAFTF 51RMNAAQHGYA GTHYVHRMGM CRQAFQNFNH TDRQAAHGFE LGFISGQLEF 101 VGQMAVNQQVGDFFKLAFLC QIRMS*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 098 shows 89.6% identity over a 125 aa overlap with a predicted ORF(ORF 098.ng) from N. gonorrhoeae:

m098/g098         10        20        30        40        50        60m098.pep MTADGLFVAFNLNAFAVVRILIPVQEDAAEAGDQFVGDVARFTFRMAFTFRMNAAQHGYA|||||||||||:|:|||||||||||:|||:||||||||||||:  |||:| ||||:||:| g098MTADGLFVAFNFNTFAVVRILIPVQQDAAQAGDQFVGDVARFAVGMAFAFGMNAAEHGHA        10        20        30        40        50        60        70        80        90       100       110       120 m098.pepGTHYVHRMGMCRQAFQNFNHTDRQAAHGFELGFISGQLEFVGQMAVNQQVGDFFKLAFLC|||:|||||||||||||||||||||||||||||||||||||||||||||| ||||||||| g098GTHHVHRMGMCRQAFQNFNHTDRQAAHGFELGFISGQLEFVGQMAVNQQVCDFFKLAFLC        70        80        90       100       110       120 m098.pepQIRMSX |||||| g098 QIRMSXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 349>:

a098.seq 1 ATGACCGCCG ATGGTCTCTT CGTCGCTTTC AACCTCAATG CGTTTGCCGT 51TGTGCGAATA TTGATACCAG TACAAGAGGA TGCTGCCGAG GCTGGCGATC 101 AGTTTGTCGGCGATGTCGCG CGCTTCACTT TCCGGATGGC TTTCACGTTC 151 AGGATGAACG CAGCCCAGCATGGATACGCC GGTACGCATT ACGTCCATCG 201 GATGGGTATG TGCAGGCAGG CTTTCCAAAACTTTAATCAC ACGGATAGGC 251 AGGCCGCGCA TGGATTTGAG CTTGGTTTTA TAAGCGGCCAGCTCGAATTT 301 GTTGGGCAGA TGGCCGTGAA TCAGCAGGTG GGCGACTTCT TCAAACTCGC351 ATTTTTGTGC CAAATCAGAA TGTCGTAAThis corresponds to the amino acid sequence <SEQ ID 350; ORF 098.a>:

a098.pep 1 MTADGLFVAF NLNAFAVVRI LIPVQEDAAE AGDQFVGDVA RFTFRMAFTF 51RMNAAQHGYA GTHYVHRMGM CRQAFQNFNH TDRQAAHGFE LGFISGQLEF 101 VGQMAVNQQVGDFFKLAFLC QIRMS* m098/a098 100.0% identity in 125 aa overlap        10        20        30        40        50        60 m098.pepMTADGLFVAFNLNAFAVVRILIPVQEDAAEAGDQFVGDVARFTFRMAFTFRMNAAQHGYA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a098MTADGLFVAFNLNAFAVVRILIPVQEDAAEAGDQFVGDVARFTFRMAFTFRMNAAQHGYA        10        20        30        40        50        60        70        80        90       100       110       120 m098.pepGTHYVHRMGMCRQAFQNFNHTDRQAAHGFELGFISGQLEFVGQMAVNQQVGDFFKLAFLC|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a098GTHYVHRMGMCRQAFQNFNHTDRQAAHGFELGFISGQLEFVGQMAVNQQVGDFFKLAFLC        70        80        90       100       110       120 m098.pepQIRMSX |||||| a098 QIRMSXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 351>:

g099.seq 1 ATGCTGGGAC GCGCGTCCAT GATGCGCCTG CCCGATATTG TCGGCGTGGA 51GCTGACGGGC AAACGGCAGG CGGGCATTAC TGCCACAGAC ATCGTGTTGG 101 CACTGACCGAATTCTTGCGT AAAGAGCGCG TGGTCGGGGC GTTTGTCGAA 151 TTTTTCGGCG AGGGCGCGAGAAGCCTGTCT ATCGGCGACC GCGCGACCAT 201 TTCCAACATG ACGCCGGAGT TCGGCGCGACTGCCGCCATG TTCGCCATCG 251 ACGCGCAAAC TATTGATTAT TTGAAACTGA CCGGACGTGACGACGCGCAG 301 GTGAAATTGG TGGAAACCTA CGCCAAAACC GCAGGCTTAT GGGCAGGTGG351 CTTGAAAACC GCCGTTTATC CGCGCGTTTT GAAATTTGAT TTGAGCAGCG 401TAACGCGCAA TATGGCAGGC CCGAGCAACC CGCACGCGCG TTTTGCCACC 451 GCCGATTTGGCGGCGAAAGG GCTGGCGAAG CCTTACGAAG AGCCTTCAGA 501 CGGCCAAATG CCTGACGGTGCAGTGATTAT TGCCGCGATT ACTTCGTGTA 551 CCAATACTTC CAACCCGCGC AACGTTGTCGCCGCCGCACT GTTGGCACGC 601 AATGCCAACC GCCTCGGCTT GAAACGCAAA CCTTGGGTGAAATCTTCGTT 651 TGCCCCGGGT TCAAAAGTAG CCGGAATCTA TTTGAAAGAA GCAGGCTTGT701 TGCCCGAAAT GGAAAAACTC GGCTTCGGTA TCGTCGCCTT CGCATGTACC 751ACCTGTAACG GCATGAgcgG CGCGCTcgaC CCGAAAATCC AACAAGAAAT 801 CATCGACCGCGAtttgtacg cCACCGCCGT ATTGTCAGGC AACCGCAACT 851 TCGACGGCCG TATCCATCCGTATGCGAAAC AGGCTTTCCT CGCTTCGCCT 901 CCTTTGGTCG TTGCCTACGC ATTGGCAGGTAGCATCCGTT TCGATATTGA 951 AAACGACGTA CTCGGCGTTG CAGACGGCCG CGAAATCCGCCTGAAAGATA 1001 TCTGGCCGAC AGACGAAGAA ATCGATGCCA TCGTTGCCGA ATATGTGAAA1051 CCGCAACAAT TCCGCGACAT TTATATCCCG ATGTCCGACA CCGGCACAGC 1101GCAAAAAGCA CCAAGCCCGC TGTACGACTG GCGACCGATG TCCACCTACA 1151 TCCGCCGTCCGCCCTATTGG GAAGGCGCAC TGGCAGGGGA ACGTACATTA 1201 AGAGGTATGC GTCCGCCGGCGATTTTGCCC GACAACATCA CCACCGACCA 1251 CATCTCgcca tCCAATGCGA TTTTGGCCGGcagTGCcgca ggtgaATATT 1301 TGGCGAAAAT GGGTTTGCCT GAAGAagaCT TCAACTCTTACGCAACCCAC 1351 CGCGGCGACC ACTTGACCGC CCAACGCGCA ACCTTCGCCA ATCCGAAACT1401 GTTTAACGAA ATGGTGAGAA ACGAAGACGG CAGCGTACGC CAAGGTtcgt 1451tggcacgcgT tgaacCAGAA GGCCAAACCA TGCGCATGTG GGAAGCCATC 1501 GAAACCTATATGAACCGCAA ACAGCCGCTT ATCATCATTG CCGGTGCGGA 1551 CTATGGTCAA GGCTCAAGCCGCGACTGGGC GGCGAAGGGC GTGCGGCTGG 1601 CGGGTGTGGA AGCCATCGCC GCCGAAGGTTTCGAGCGCAT CCACCGCACC 1651 AACCTCATCG GCATGGGCGT CTTGCCGCTG CAATTCAAACCCGGCACCAA 1701 CCGCCATACC CTGCAACTGG ACGGTACGGA AACCTACGAC GTTGTCGGCG1751 AACGCACACC GCGCTGCGGC CTGACCCTCG TGATTCACCG TAAAAACGGA 1801GAAACCGTCG AAGTTCCGGT TACCTGCCGC CCCGATACCG CAGAAGAAGC 1851 ATTGGTATATGAAGCCGGCG GCGTATTGCA ACGGTTTGCA CAGGACTTTT 1901 TGGAAGGGAA CGCGGCTTAGThis corresponds to the amino acid sequence <SEQ ID 352; ORF 099.ng>:

g099.pep 1 MLGRASMMRL PDIVGVELTG KRQAGITATD IVLALTEFLR KERVVGAFVE 51FFGEGARSLS IGDRATISNM TPEFGATAAM FAIDAQTIDY LKLTGRDDAQ 101 VKLVETYAKTAGLWAGGLKT AVYPRVLKFD LSSVTRNMAG PSNPHARFAT 151 ADLAAKGLAK PYEEPSDGQMPDGAVIIAAI TSCTNTSNPR NVVAAALLAR 201 NANRLGLKRK PWVKSSFAPG SKVAGIYLKEAGLLPEMEKL GFGIVAFACT 251 TCNGMSGALD PKIQQEIIDR DLYATAVLSG NRNFDGRIHPYAKQAFLASP 301 PLVVAYALAG SIRFDIENDV LGVADGREIR LKDIWPTDEE IDAIVAEYVK351 PQQFRDIYIP MSDTGTAQKA PSPLYDWRPM STYIRRPPYW EGALAGERTL 401RGMRPPAILP DNITTDHISP SNAILAGSAA GEYLAKMGLP EEDFNSYATH 451 RGDHLTAQRATFANPKLFNE MVRNEDGSVR QGSLARVEPE GQTMRMWEAI 501 ETYMNRKQPL IIIAGADYGQGSSRDWAAKG VRLAGVEAIA AEGFERIHRT 551 NLIGMGVLPL QFKPGTNRHT LQLDGTETYDVVGERTPRCG LTLVIHRKNG 601 ETVEVPVTCR PDTAEEALVY EAGGVLQRFA QDFLEGNAA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 353>:

m099.seq 1 ATGCTGGGAC GCGCGTCCAT GATGCGCCTG CCCGATATTG TCGGCGTTGA 51GCTGAACGGC AAACGGCAGG CGGGCATTAC GGCGACGGAT ATTGTGTTGG 101 CACTGACCGAGTTTCTGCGC AAAGAACGCG TGGTCGGGGC GTTTGTCGAA 151 TTCTTCGGCG AGGGCGCGAGAAGCCTGTCT ATCGGCGACC GCGCGACCAT 201 TTCCAACATG ACGCCGGAGT TCGGCGCGACTGCCGCGATG TTCGCTATTG 251 ATGAGCAAAC CATTGATTAT TTGAAACTGA CCGGACGCGACGACGCGCAG 301 GTGAAATTGG TGGAAACCTA CGCCAAAACC GCAGGCTTGT GGGCAGATGC351 CTTGAAAACC GCCGTTTATC CTCGCGTTTT GAAATTTGAT TTGAGCAGCG 401TAACGCGCAA TATGGCAGGC CCAAGTAACC CGCATGCCCG TTTTGCGACC 451 GCCGATTTGGCGGCGAAAGG GCTGGCGAAG CCTTACGAAG AGCCTTCGGA 501 CGGCCAAATG CCCGACGGCTCGGTCATCAT CGCCGCGATT ACCAGTTGCA 551 CCAACACTTC CAACCCGCGC AACGTTGTTGCCGCCGCGCT CTTGGCACGC 601 AATGCCAACC GTCTCGGCTT GAAACGCAAA CCTTGGGTGAAATCTTCGTT 651 TGCCCCGGGT TCAAAAGTAG CCGAAATCTA TTTGAAAGAA GCGGGCCTGT701 TGCCCGAAAT GGAAAAACTC GGCTTCGGTA TCGTCGCCTT CGCCTGCACC 751ACCTGCAACG GCATGAGTGG CGCGCTGGAT CCGAAAATCC AGAAAGAAAT 801 CATCGACCGCGATTTGTACG CCACCGCCGT ATTATCAGGC AACCGCAACT 851 TCGACGGCCG TATCCACCCGTATGCGAAAC AGGCTTTCCT CGCTTCGCCT 901 CCGTTGGTCG TTGCCTACGC GCTGGCAGGCAGTATCCGTT TCGATATTGA 951 AAACGACGTA CTCGGCGTTG CAGACGGCAA GGAAATCCGCCTGAAAGACA 1001 TTTGGCCTGC CGATGAAGAA ATCGATGCCG TCGTTGCCGA ATATGTGAAA1051 CCGCAGCAGT TCCGCGATGT GTATGTACCG ATGTTCGACA CCGGCACAGC 1101GCAAAAAGCA CCCAGTCCGC TGTACGATTG GCGTCCGATG TCCACCTACA 1151 TCCGCCGTCCGCCTTACTGG GAAGGCGCGC TGGCAGGGGA ACGCACATTA 1201 AGAGGTATGC GTCCGCTGGCGATTTTGCCC GACAACATCA CCACCGACCA 1251 CCTCTCGCCG TCCAATGCGA TTTTGGCCGTCAGTGCCGCA GGCGAGTATT 1301 TGGCGAAAAT GGGTTTGCCT GAAGAAGACT TCAACTCTTACGCAACCCAC 1351 CGCGGCGACC ACTTGACCGC CCAACGCGCT ACCTTCGCCA ATCCGAAACT1401 GTTTAACGAA ATGGTGAAAA ACGAAGACGG CAGCGTGCGC CAAGGCTCGT 1451TCGCCCGCGT CGAACCCGAA GGCGAAACCA TGCGCATGTG GGAAGCCATC 1501 GAAACCTATATGAACCGCAA ACAGCCGCTC ATCATCATTG CCGGTGCGGA 1551 CTATGGTCAA GGCTCAAGCCGCGACTGGGC TGCAAAAGGC GTACGCCTCG 1601 CCGGCGTAGA AGCGATTGTT GCCGAAGGCTTCGAGCGTAT CCACCGCACC 1651 AACCTTATCG GCATGGGCGT GTTGCCGCTG CAGTTCAAACCCGACACCAA 1701 CCGCCATACC CTGCAACTGG ACGGTACGGA AACCTACGAC GTGGTCGGCG1751 AACGCACACC GCGCTGCGAC CTGACCCTCG TGATTCACCG TAAAAACGGC 1801GAAACCGTTG AAGTTCCCGT TACCTGCTGC CTCGATACTG CAGAAGAAGT 1851 ATTGGTATATGAAGCCGGCG GCGTGTTGCA ACGGTTTGCA CAGGATTTTT 1901 TGGAAGGGAA CGCGGCTTAGThis corresponds to the amino acid sequence <SEQ ID 354; ORF 099>:

m099.pep 1 MLGRASMMRL PDIVGVELNG KRQAGITATD IVLALTEFLR KERVVGAFVE 51FFGEGARSLS IGDRATISNM TPEFGATAAM FAIDEQTIDY LKLTGRDDAQ 101 VKLVETYAKTAGLWADALKT AVYPRVLKFD LSSVTRNMAG PSNPHARFAT 151 ADLAAKGLAK PYEEPSDGQMPDGSVIIAAI TSCTNTSNPR NVVAAALLAR 201 NANRLGLKRK PWVKSSFAPG SKVAEIYLKEAGLLPEMEKL GFGIVAFACT 251 TCNGMSGALD PKIQKEIIDR DLYATAVLSG NRNFDGRIHPYAKQAFLASP 301 PLVVAYALAG SIRFDIENDV LGVADGKEIR LKDIWPADEE IDAVVAEYVK351 PQQFRDVYVP MFDTGTAQKA PSPLYDWRPM STYIRRPPYW EGALAGERTL 401RGMRPLAILP DNITTDHLSP SNAILAVSAA GEYLAKMGLP EEDFNSYATH 451 RGDHLTAQRATFANPKLFNE MVKNEDGSVR QGSFARVEPE GETMRMWEAI 501 ETYMNRKQPL IIIAGADYGQGSSRDWAAKG VRLAGVEAIV AEGFERIHRT 551 NLIGMGVLPL QFKPDTNRHT LQLDGTETYDVVGERTPRCD LTLVIHRKNG 601 ETVEVPVTCC LDTAEEVLVY EAGGVLQRFA QDFLEGNAA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 099 shows 96.2% identity over a 639 aa overlap with a predicted ORF(ORF 099.ng) from N. gonorrhoeae:

m099/g099         10        20        30        40        50        60m099.pep MLGRASMMRLPDIVGVELNGKRQAGITATDIVLALTEFLRKERVVGAFVEFFGEGARSLS||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||| g099MLGRASMMRLPDIVGVELTGKRQAGITATDIVLALTEFLRKERVVGAFVEFFGEGARSLS        10        20        30        40        50        60        70        80        90       100       110       120 m099.pepIGDRATISNMTPEFGATAAMFAIDEQTIDYLKLTGRDDAQVKLVETYAKTAGLWADALKT||||||||||||||||||||||||| ||||||||||||||||||||||||||| :||| g099IGDRATISNMTPEFGATAAMFAIDAQTIDYLKLTGRDDAQVKLVETYAKTAGLWAGGLKT        70        80        90       100       110       120       130       140       150       160       170       180 m099.pepAVYPRVLKFDLSSVTRNMAGPSNPHARFATADLAAKGLAKPYEEPSDGQMPDGSVIIAAI|||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||| g099AVYPRVLKFDLSSVTRNMAGPSNPHARFATADLAAKGLAKPYEEPSDGQMPDGAVIIAAI       130       140       150       160       170       180       190       200       210       220       230       240 m099.pepTSCINTSNPRNVVAAALLARNANRLGLKRKPWVKSSFAPGSKVAEIYLKEAGLLPEMEKL|||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||| g099TSCINTSNPRNVVAAALLARNANRLGLKRKPWVKSSFAPGSKVAGIYLKEAGLLPEMEKL       190       200       210       220       230       240       250       260       270       280       290       300 m099.pepGFGIVAFACTTCNGMSGALDPKIQKEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASP||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||| g099GFGIVAFACTTCNGMSGALDPKIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASP       250       260       270       280       290       300       310       320       330       340       350       360 m099.pepPLVVAYALAGSIRFDIENDVLGVADGKEIRLKDIWPADEEIDAVVAEYVKPQQFRDVYVP||||||||||||||||||||||||||:|||||||||:||||||:||||||||||||:|:| g099PLVVAYALAGSIRFDIENDVLGVADGREIRLKDIWPTDEEIDAIVAEYVKPQQFRDIYIP       310       320       330       340       350       360       370       380       390       400       410       420 m099.pepMFDTGTAQKAPSPLYDWRPMSTYIRRPPYWEGALAGERTLRGMRPLAILPDNITTDHLSP| ||||||||||||||||||||||||||||||||||||||||||| |||||||||||:|| g099MSDTGTAQKAPSPLYDWRPMSTYIRRPPYWEGALAGERTLRGMRPPAILPDNITTDHISP       370       380       390       400       410       420       430       440       450       460       470       480 m099.pepSNAILAVSAAGEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVKNEDGSVR|||||| |||||||||||||||||||||||||||||||||||||||||||||:||||||| g099SNAILAGSAAGEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVRNEDGSVR       430       440       450       460       470       480       490       500       510       520       530       540 m099.pepQGSFARVEPEGETMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIV|||:|||||||:|||||||||||||||||||||||||||||||||||||||||||||||: g099QGSLARVEPEGQTMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIA       490       500       510       520       530       540       550       560       570       580       590       600 m099.pepAEGFERIHRTNLIGMGVLPLQFKPDTNRHTLQLDGTETYDVVGERTPRCDLTLVIHRKNG|||||||||||||||||||||||| |||||||||||||||||||||||| |||||||||| g099AEGFERIHRTNLIGMGVLPLQFKPGTNRHTLQLDGTETYDVVGERTPRCGLTLVIHRKNG       550       560       570       580       590       600       610       620       630       640 m099.pepETVEVPVTCCLDTAEEVLVYEAGGVLQRFAQDFLEGNAAX|||||||||  |||||:||||||||||||||||||||||| g099ETVEVPVTCRPDTAEEALVYEAGGVLQRFAQDFLEGNAAX       610       620       630       640The following partial DNA sequence was identified in N. meningitidis<SEQ ID 355>:

a099.seq 1 ATGCTGGGAC GCGCGTCCAT GATGCGCCTG CCCGATATTG TCGGCGTTGA 51GCTGAACGGC AAACGGAAGG CGGGCATTAC GGCGACGGAT ATTGTGTTGG 101 CACTGACCGAGTTTCTGCGC AAAGAACGCG TGGTCGGGGC GTTTGTCGAA 151 TTCTTCGGCG AGGGCGCGAGAAGCCTGTCT ATCGGCGACC GCGCGACCAT 201 TTCCAACATG ACGCCGGAGT TCGGCGCGACTGCCGCGATG TTCGCTATTG 251 ATGAGCAAAC CATTGATTAT TTGAAACTGA CCGGACGCGACGACGCGCAG 301 GTGAAATTGG TGGAAACCTA CGCCAAAACC GCAGGCTTGT GGGCAGATGC351 CTTGAAAACC GCCGTTTATC CGCGCGTTTT GAAATTTGAT TTGAGCAGCG 401TAACGCGCAA TATGGCAGGC CCGAGCAACC CGCACGCGCG TTTTGCGACC 451 GCCGATTTGGCCGGCAAAGG CTTGGCTAAA CCTTACGAAG AGCCTTCAGA 501 CGGCCAAATG CCTGACGGTGCAGTGATTAT TGCCGCGATT ACTTCCTGTA 551 CCAATACTTC CAATCCGCGC AACGTTGTCGCCGCCGCGCT GTTGGCACGC 601 AATGCCAACC GCCTCGGCTT GCAACGCAAA CCTTGGGTGAAATCTTCGTT 651 TGCCCCGGGT TCAAAAGTAG CCGAAATCTA TTTGAAAGAA GCAGATCTGC701 TGCCCGAAAT GGAAAAACTC GGCTTCGGTA TCGTTGCCTT CGCATGTACC 751ACCTGTAACG GCATGAGCGG CGCGCTGGAT CCGAAAATCC AGAAAGAAAT 801 CATCGACCGCGATTTGTACG CCACCGCCGT ATTGTCAGGC AACCGCAACT 851 TTGACGGCCG TATCCATCCGTATGCGAAAC AGGCTTTCCT CGCTTCGCCT 901 CCGTTGGTCG TTGCCTACGC GCTGGCAGGCAGCATCCGTT TCGATATTGA 951 AAACGACGTA CTCGGCGTTG CAGACGGCAA AGAAATCCGCCTGAAAGACA 1001 TTTGGCCTAC CGATGAAGAA ATCGATGCCA TCGTTGCCGA ATATGTGAAA1051 CCGCAGCAAT TTCGCGACGT TTATATCCCG ATGTTCGACA CCGGCACAGC 1101GCAAAAAGCA CCAAGCCCGC TGTACGACTG GCGTCCAATG TCTACCTATA 1151 TCCGCCGCCCACCTTACTGG GAAGGCGCAC TGGCAGGGGA ACGCACATTA 1201 AGCGGTATGC GTCCGCTGGCGATTTTGCCC GACAACATCA CCACCGACCA 1251 TCTCTCGCCA TCCAATGCGA TTTTGGCAAGCAGTGCCGCA GGCGAATATT 1301 TGGCAAAAAT GGGTTTGCCT GAAGAAGACT TCAACTCTTACGCAACCCAC 1351 CGTGGCGACC ACTTGACCGC CCAACGCGCA ACCTTCGCCA ATCCGAAACT1401 GTTTAACGAA ATGGTGAGAA ACGAAGACGG CAGCGTACGC CAAGGTTCGC 1451TGGCACGCGT TGAACCCGAA GGCCAAACCA TGCGCATGTG GGAAGCCATC 1501 GAAACCTATATGAACCGCAA ACAGCCGCTC ATCATCATTG CCGGCGCGGA 1551 CTACGGTCAA GGCTCAAGCCGCGACTGGGC TGCAAAAGGC GTACGCCTCG 1601 CCGGCGTGGA AGCGATTGTT GCCGAAGGCTTCGAGCGTAT CCACCGCACC 1651 AACTTGATCG GTATGGGCGT GTTGCCGCTG CAGTTCAAACCGGGTACCAA 1701 CCGCCACACC CTGCAACTGG ACGGTACGGA AACCTACGAC GTTGTCGGCG1751 AACGCACACC GCGCTGCGAC CTGACCCTTG TGATTCACCG TAAAAACGGC 1801GAGACCGTCG AAGTCCCCAT TACCTGCCGC CTCGATACCG CAGAAGAAGT 1851 GTTGGTATATGAAGCCGGTG GCGTATTGCA ACGGTTTGCA CAGGATTTTT 1901 TGGAAGGGAA CGCGGCTTAGThis corresponds to the amino acid sequence <SEQ ID 356; ORF 099.a>:

a099.pep 1 MLGRASMMRL PDIVGVELNG KRKAGITATD IVLALTEFLR KERVVGAFVE 51FFGEGARSLS IGDRATISNM TPEFGATAAM FAIDEQTIDY LKLTGRDDAQ 101 VKLVETYAKTAGLWADALKT AVYPRVLKFD LSSVTRNMAG PSNPHARFAT 151 ADLAGKGLAK PYEEPSDGQMPDGAVIIAAI TSCTNTSNPR NVVAAALLAR 201 NANRLGLQRK PWVKSSFAPG SKVAEIYLKEADLLPEMEKL GFGIVAFACT 251 TCNGMSGALD PKIQKEIIDR DLYATAVLSG NRNFDGRIHPYAKQAFLASP 301 PLVVAYALAG SIRFDIENDV LGVADGKEIR LKDIWPTDEE IDAIVAEYVK351 PQQFRDVYIP MFDTGTAQKA PSPLYDWRPM STYIRRPPYW EGALAGERTL 401SGMRPLAILP DNITTDHLSP SNAILASSAA GEYLAKMGLP EEDFNSYATH 451 RGDHLTAQRATFANPKLFNE MVRNEDGSVR QGSLARVEPE GQTMRMWEAI 501 ETYMNRKQPL IIIAGADYGQGSSRDWAAKG VRLAGVEAIV AEGFERIHRT 551 NLIGMGVLPL QFKPGTNRHT LQLDGTETYDVVGERTPRCD LTLVIHRKNG 601 ETVEVPITCR LDTAEEVLVY EAGGVLQRFA QDFLEGNAA*m099/a099 97.5% identity in 639 aa overlap        10        20        30        40        50        60 m099.pepMLGRASMMRLPDIVGVELNGKRQAGITATDIVLALTEFLRKERVVGAFVEFFGEGARSLS||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||| a099MLGRASMMRLPDIVGVELNGKRKAGITATDIVLALTEFLRKERVVGAFVEFFGEGARSLS        10        20        30        40        50        60        70        80        90       100       110       120 m099.pepIGDRATISNMTPEFGATAAMFAIDEQTIDYLKLTGRDDAQVKLVETYAKTAGLWADALKT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a099IGDRATISNMTPEFGATAAMFAIDEQTIDYLKLTGRDDAQVKLVETYAKTAGLWADALKT        70        80        90       100       110       120       130       140       150       160       170       180 m099.pepAVYPRVLKFDLSSVTRNMAGPSNPHARFATADLAAKGLAKPYEEPSDGQMPDGSVIIAAI||||||||||||||||||||||||||||||||||:||||||||||||||||||:|||||| a099AVYPRVLKFDLSSVTRNMAGPSNPHARFATADLAGKGLAKPYEEPSDGQMPDGAVIIAAI       130       140       150       160       170       180       190       200       210       220       230       240 m099.pepTSCTNTSNPRNVVAAALLARNANRLGLKRKPWVKSSFAPGSKVAETYLKEAGLLPEMEKL|||||||||||||||||||||||||||:||||||||||||||||||||||| |||||||| a099TSCTNTSNPRNVVAAALLARNANRLGLQRKPWVKSSFAPGSKVAEIYLKEADLLPEMEKL       190       200       210       220       230       240       250       260       270       280       290       300 m099.pepGFGIVAFACTTCNGMSGALDPKIQKEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a099GFGIVAFACTTCNGMSGALDPKIQKEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASP       250       260       270       280       290       300       310       320       330       340       350       360 m099.pepPLVVAYALAGSIRFDIENDVLGVADGKEIRLKDIWPADEEIDAVVAEYVKPQQFRDVYVP||||||||||||||||||||||||||||||||||||:||||||:||||||||||||||:| a099PLVVAYALAGSIRFDIENDVLGVADGKEIRLKDIWPTDEEIDAIVAEYVKPQQFRDVYIP       310       320       330       340       350       360       370       380       390       400       410       420 m099.pepMFDTGTAQKAPSPLYDWRPMSTYIRRPPYWEGALAGERTLRGMRPLAILPDNITTDHLSP|||||||||||||||||||||||||||||||||||||||| ||||||||||||||||||| a099MFDTGTAQKAPSPLYDWRPMSTYIRRPPYWEGALAGERTLSGMRPLAILPDNITTDHLSP       370       380       390       400       410       420       430       440       450       460       470       480 m099.pepSNAILAVSAAGEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVKNEDGSVR|||||| |||||||||||||||||||||||||||||||||||||||||||||:||||||| a099SNAILASSAAGEYLAKMGLPEEDFNSYATHRGDHLTAQRATFANPKLFNEMVRNEDGSVR       430       440       450       460       470       480       490       500       510       520       530       540 m099.pepQGSFARVEPEGETMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIV|||:|||||||:|||||||||||||||||||||||||||||||||||||||||||||||| a099QGSLARVEPEGQTMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIV       490       500       510       520       530       540       550       560       570       580       590       600 m099.pepAEGFERIHRTNLIGMGVLPLQFKPDTNRHTLQLDGTETYDVVGERTPRCDLTLVIHRKNG|||||||||||||||||||||||| ||||||||||||||||||||||||||||||||||| a099AEGFERIHRTNLIGMGVLPLQFKPGTNRHTLQLDGTETYDVVGERTPRCDLTLVIHRKNG       550       560       570       580       590       600       610       620       630       640 m099.pepETVEVPVTCCLDTAEEVLVYEAGGVLQRFAQDFLEGNAAX||||||:|| |||||||||||||||||||||||||||||| a099ETVEVPITCRLDTAEEVLVYEAGGVLQRFAQDFLEGNAAX       610       620       630       640The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 357>:

g102.seq 1 AtgtCCGCCA AAactccgtc gctcttcggc ggcgcgatga Ttatcgccgg 51gaaggttatc ggcgcAGgta tgttccccaa ccccaccgcc aacttggggg 101 acgggttaataggctcgctg attgtgctgc tgtacacctg gtttccattc 151 tcctccggcg ccctcatgattttggaagtc aacacccata acCCccgagg 201 ggcaAGtttt gacaccATGg tcAAagacctgctcgGaCGc ggctggaaca 251 tcatcaacgg catcgccgtc gctttggTCc tatacggctcgacctacgcg 301 tacattttag tcggcggtga cctGACCGCC AAAGGCAtcg GCAgCGCAGT351 AGGCGGCAAA ATTTCgctca CCGTCGGACA actcgtcttc tTCGGCATCC 401TCGCCTTTTG CGTATGGGCA TCCGCACGCT TGGTCGACCG CTTTACCGGC 451 GTCCTCATCGGCGGCATGGT ATTAACCTTT ATTTGGGCAA CCGGCGGCCT 501 GGTTGCCGAT GCCAAACCGTCCGTCCTCTT CGACACCCAA GCCCCCGTCG 551 GCACCGGCTA CTGGATTTAC GCCGCCACCGCCCTGCCCGT CTGCCTCGCT 601 TCCTTCGGCT TCCACGGCAA CGTTTCCAGC CTGCTCAAATACTTTAAAGG 651 CGACGcgcCc aaagtGgCGA aATCcatctg gGcaggtaca ttggTTGCCt701 tggtaattta cgtccTCTgg caaaccgcca tCcaaagcaa ccTGCcgcgc 751aacgagttcg cCCCcgtgat tgccgccgag aggcaactCT CCGTCCTgaa 801 tgaaacccTGtccaaattcg cccaaaccgg cgatatggat aAaatattgt 851 ccctatttcc ctacatggcaatcgccacct cctttttagg cgTAACctta 901 ggcctgtttg acaacatcgc cgacatcttcaaatggaacg acagtatgtc 951 cgggcggggc accaaaaccg tcgcgctgaa cttcctgccgCCCCtgattt 1001 cctggctgct cctccccacc ggcttcttta ccgccattgg tgcgtccggc1051 ctggcggcaa ccgtctggga ccaagGcatc atccccgcca tgctgctcta 1101cgtttccccc caaaaaattG gcGcaggcaa gacttataAa gtttaCGGCG 1151 gcttgtggctgatgttagtc ttccttttcg gcatcgccaa catcgccgca 1201 CAGGTATTGA GccaAatgGaACtcgtCccc GTATTTAAAG GATAAThis corresponds to the amino acid sequence <SEQ ID 358; ORF 102.ng>:

g102.pep 1 MSAKTPSLFG GAMIIAGKVI GAGMFPNPTA NLGDGLIGSL IVLLYTWFPF 51SSGALMILEV NTHNPRGASF DTMVKDLLGR GWNIINGIAV ALVLYGSTYA 101 YILVGGDLTAKGIGSAVGGK ISLTVGQLVF FGILAFCVWA SARLVDRFTG 151 VLIGGMVLTF IWATGGLVADAKPSVLFDTQ APVGTGYWIY AATALPVCLA 201 SFGFHGNVSS LLKYFKGDAPKVAKSIWAGT LVALVIYVLW QTAIQSNLPR 251 NEFAPVIAAE RQLSVLNETL SKFAQTGDMDKILSLFPYMA IATSFLGVTL 301 GLFDNIADIF KWNDSMSGRG TKTVALNFLPPLISWLLLPT GFFTAIGASG 351 LAATVWDQGI IPAMLLYVSP QKIGAGKTYKVYGGLWLMLV FLFGIANIAA 401 QVLSQMELVP VFKG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 359>:

m102.seq 1 ATGCCCAACA AAACCCCTTC ACTGTTCGGC GGCGCGATGA TTATCGCCGG 51CACGGTCATC GGCGCAGGCA TGCTCGCCAA CCCGACCGCC ACATCCGGCG 101TATGGTTTAC CGGCTCGCTG GCCGTGTTGC TGTACACCTG GTTTTCTATG 151CTTTCCAGCG GCCTGATGAT TTTGGAAGTC AACACCCATT ATCCGCACGG 201CGCAAGTTTC GACACGATGG TCAAAGACCT GCTCGGACGC GGCTGGAACA 251TCATCAACGG CATCGCCGTC GCCTTCGTTT TATACCTGCT TACTTACGCT 301TATATCTTCG TCGGCGGCGA CCTGACCGCC AAAGGCTTAG GCAGCGCGGC 351AGGCGGCGAC GTTTCACTCA CCGTCGGACA ACTCGTCTTC TTCGGCATCC 401TCGCCTTTTG CGTATGGGCA TCCGCACGCT TGGTCGACCG CTTCACCGGC 451GTCCTTATCG GCGGCATGGT ATTGACCTTT ATTTGGGCGG CCGGCGGGCT 501GATTGCCGAT GCCAAGCCGT CCGTCCTCTT CGATACCCAA GCCCCCGCCG 551GCACAAACTA CTGGATTTAC GCCGCCACCG CCCTGCCCGT CTGCCTCGCT 601TCCTTCGGCT TCCACGGCAA CGTCTCCAGC CTGCTCAAAT ACTTTAAAGG 651CGACGCGCCC AAAGTGGCTA AATCCATCTG GACGGGCACA CTGATTGCGC 701TGGTAATTTA CGTCCTCTGG CAAACCGCCA TCCAAGGCAA CCTGCCGCGC 751AACGAGTTCG CCCCCGTCAT CGCCGCCGAA GGGCAAGTCT CCGTCCTCAT 801CGAAACCCTG TCCAAATTCG CCCAAACCGG CAATATGGAC AAAATATTGT 851CCCTGTTTTC CTATATGGCG ATCGCCACCT CGTTTTTAGG CGTAACGCTC 901GGACTCTTCG ACTACATCGC CGACATCTTC AAATGGAACG ACAGCATCTC 951CGGCCGCACC AAAACCGCCG CGCTGACCTT CCTGCCGCCC CTGATTTCCT 1001GCCTGCTCTT CCCCACCGGC TTCGTTACCG CCATCGGCTA CGTCGGCCTG 1051GCGGCAACCG TCTGGACAGG CATCATCCCC GCCATGCTGC TCTACCGTTC 1101GCGCAAAAAA TTCGGCGCAG GCAAAACCTA TAAAGTTTAC GGCGGCTTGT 1151GGCTGATGGT TTGGGTCTTC CTTTTCGGCA TCGTCAACAT CGCCGCACAG 1201GTATTGAGCC AAATGGAACT CGTCCCCGTA TTTAAAGGAT AAThis corresponds to the amino acid sequence <SEQ ID 360; ORF 102>:

m102.pep.. 1 MPNKTPSLFG GAMIIAGTVI GAGMLANPTA TSGVWFTGSL AVLLYTWFSM 51LSSGLMILEV NTHYPHGASF DTMVKDLLGR GWNIINGIAV AFVLYLLTYA 101YIFVGGDLTA KGLGSAAGGD VSLTVGQLVF FGILAFCVWA SARLVDRFTG 151VLIGGMVLTF IWAAGGLIAD AKPSVLFDTQ APAGTNYWIY AATALPVCLA 201SFGFHGNVSS LLKYFKGDAP KVAKSIWTGT LIALVIYVLW QTAIQGNLPR 251NEFAPVIAAE GQVSVLIETL SKFAQTGNMD KILSLFSYMA IATSFLGVTL 301GLFDYIADIF KWNDSISGRT KTAALTFLPP LISCLLFPTG FVTAIGYVGL 351AATVWTGIIP AMLLYRSRKK FGAGKTYKVY GGLWLMVWVF LFGIVNIAAQ 401VLSQMELVPV FKG* m102/g102 86.0% identity in 415 aa overlap         10        20        30        40        50        60 m102.pep MPNKTPSLFGGAMIIAGTVIGAGMLANPTATSGVWFTGSLAVLLYTWFSMLSSGLMILEV  | |||||||||||||| ||||||: ||||: |  : |||||||||| : |::|||||| g102 MSAKTPSLFGGAMIIAGKVIGAGMFPNPTANLGDGLIGSLIVLLYTWFPFSSGALMILEV         10        20        30        40        50        60         70        80        90       100       110       120 m102.pep NTHYPHGASFDTMVKDLLGRGWNIINGIAVAFVLYLLTYAYIFVGGDLTAKGLGSAAGGD  ||||:|||||||||||||||||||||||||:|||  |||||:|||||||||:|||:|| g102 NTHNPRGASFDTMVKDLLGRGWNIINGIAVALVLYGSTYAYILVGGDLTAKGIGSAVGGK         70        80        90       100       110       120        130       140       150       160       170       180 m102.pep VSLTVGQLVFFGILAFCVWASARLVDRFTGVLIGGMVLTFIWAAGGLIADAKPSVLFDTQ :||||||||||||||||||||||||||||||||||||||||||:|||:|||||||||||| g102 ISLTVGQLVFFGILAFCVWASARLVDRFTGVLIGGMVLTFIWATGGLVADAKPSVLFDTQ        130       140       150       160       170       180        190       200       210       220       230       240 m102.pep APAGTNYWIYAATALPVCLASFGFHGNVSSLLKYFKGDAPKVAKSIWTGTLIALVIYVLW ||:||:|||||||||||||||||||||||||||||||||||||||||:|||:|||||||| g102 APVGLGYWIYAATALPVCLASFGFHGNVSSLLKYFKGDAPKVAKSIWAGTLVALVIYVLW        190       200       210       220       230       240        250       260       270       280       290       300 m102.pep QTAIQGNLPRNEFAPVIAAEGQVSVLIETLSKFAQTGNMDKILSLFSYMAIATSFLGVTL |||||:|||||||||||||| |:||| ||||||||||:|||||||| ||||||||||||| g102 QTAIQSNLPRNEFAPVIAAERQLSVLNETLSKFAQTGDMDKILSLFPYMAIATSFLGVTL        250       260       270       280       290       300        310        320       330       340       350 m102.pep GLFDYIADIFKWNDSISGR-TKTAALTFLPPLISCLLFPTGFVTAIGYVGLAATVWT-GI  ||||||||||||||:||| |||:||:||||||| ||:|||| ||||  ||||||| || g102 GLFDNIADIFKWNDSMSGRGTKTVALNFLPPLISWLLLPTGFFTAIGASGLAATVWDQGI        310       320       330       340       350       360360       370       380       390       400       410 m102.pep IPAMLLYRSRKKFGAGKTYKVYGGLWLMVWVFLFGIVNIAAQVLSQMELVPVFKGX  ||||||| |:|:|||||||||||||||: ||||||:||||||||||||||||||| g102 IPAMLLYVSPQKIGAGKTYKVYGGLWLML-VFLFGIANIAAQVLSQMELVPVFKGX        370       380        390       400       410The following partial DNA sequence was identified in N. meningitidis<SEQ ID 361>:

a102.seq 1 ATGCCCACCA AAACCCCTTC ACTGTTCGGC GGCGCGATGA TTATCGCCGG 51CACGNTCATC GGCGCAGGTA TGCTCGCCAA CCCGACCGCC ACATCCGGCG 101TATGGTTTAC CGGCTCGCTG GCCGTGTTGC TGTACACCTG GTTTTCCATG 151CTCTCCAGCG GCCTGATGAT TTTGGAAGTC AACACCCACT ACCCCCACGG 201CGCGANCTTC GACACCATGG TTAAAGACCT GCTCGGACGG AGCTGGAACA 251TCATCAACGG CATCGCCGTC GCCTTCGTTT TATACCTGCT TACTTACGCT 301TATATCTTCG TCGGCGGCGA CCTGACCGCC AAAGGCTTAG GCAGCGCGGC 351AGGCGGCAAT GTTTCACTCA CCGTCGGACA ACTCGTCTTC TTCGGCATTC 401TCGCCTTTTG CGTATGGGCA TCCGCACGCT TGGTCGACCG ATTCACCAGC 451GTCCTCATCG GCGGCATGGT ATTAACCTTT ATTTGGGCAA CCGGCGGCCT 501GATTGCCGAT GCCAAACTGC CCGTCCTCTT CGACACCCAA GCCCCTACCG 551GCACCAACTA CTGGATTTAT GTCGCCACCG CCCTGCCCGT CTGCCTTGCG 601TCATTCGGTT TCCACGGCAA CGTCTCCAGC CTGCTCAAAT ACTTTAAAGG 651CGACGCGCCC AAAGTGGCTA AATCCATCTG GACGGGCACA CTGATTGCGC 701TGGTAATTTA CGTCCTCTGG CAAACCGCCA TCCAANGCAA CCTGCCGCGC 751AACGAGTTCG CCCCCGTGAT TGCCGCCGAA GGGCAAGTCT CCGTCNTGAT 801TGAAACCCTG TCCAAATTCG CCCAAACCGG CAATATGGAC AAAATATTGT 851CCCTGTTTTC CTATATGGCG ATCGCCACCT CGTTTTTAGG CGTAACGCTC 901GGACTCTTCG ACTACATCGC CGACATCTTC AAATGGAACG ACAGCGTGTC 951CGGCCGCACC AAAACCGCCG CGCTGACCTT CCTGCCGCCT NTAATTTCCT 1001GCCTGCTCTT CCCCACCGGC TTTGTTACCG CCATCGGNTA CGTCGGCCTG 1051GCGGCAACCG TCTGGACAGG CATCATCCCC GCCATGCTGC TNTACCGTTC 1101GCGCAAAAAA TTCGGCGCAG GCAAAACCTA TAAAGTTTAC GGCGGCTTGT 1151GGCTGATGGT TTGGGTCTTC CTTTTCGGCA TCNTCAACAT CGCCGCACAN 1201GTATTGAGCC AAATGGAACT CGTCCCCGTA TTTAAAGGAT AA 1202This corresponds to the amino acid sequence <SEQ ID 362; ORF 102.a>:

a102.pep 1 MPTKTPSLFG GAMIIAGTXI GAGMLANPTA TSGVWFTGSL AVLLYTWFSM 51LSSGLMILEV NTHYPHGAXF DTMVKDLLGR SWNIINGIAV AFVLYLLTYA 101YIFVGGDLTA KGLGSAAGGN VSLTVGQLVF FGILAFCVWA SARLVDRFTS 151VLIGGMVLTF IWATGGLIAD AKLPVLFDTQ APTGTNYWIY VATALPVCLA 201SFGFHGNVSS LLKYFKGDAP KVAKSIWTGT LIALVIYVLW QTAIQXNLPR 251NEFAPVIAAE GQVSVXIETL SKFAQTGNMD KILSLFSYMA IATSFLGVTL 301GLFDYIADIF KWNDSVSGRT KTAALTFLPP XISCLLFPTG FVTAIGYVGL 351AATVWTGIIP AMLLYRSRKK FGAGKTYKVY GGLWLMVWVF LFGIXNIAAX 401VLSQMELVPV FKG* m102/a102 95.9% identity in 413 aa overlap        10        20        30        40        50        60 m102.pepMPNKTPSLFGGAMIIAGTVIGAGMLANPTATSGVWFTGSLAVLLYTWFSMLSSGLMILEV||:||||||||||||||| ||||||||||||||||||||||||||||||||||||||||| a102MPTKTPSLFGGAMIIAGTXIGAGMLANPTATSGVWFTGSLAVLLYTWFSMLSSGLMILEV        10        20        30        40        50        60        70        80        90       100       110       120 m102.pepNTHYPHGASFDTMVKDLLGRGWNIINGIAVAFVLYLLTYAYIFVGGDLTAKGLGSAAGGD |||||||||||||||||||:||||||||||||||||||||||||||||||||||||||: a102NTHYPHGAXFDTMVKDLLGRSWNIINGIAVAFVLYLLTYAYIFVGGDLTAKGLGSAAGGN        70        80        90       100       110       120       130       140       150       160       170       180 m102.pepVSLTVGQLVFFGILAFCVWASARLVDRFTGVLIGGMVLTFIWAAGGLIADAKPSVLFDTQ|||||||||||||||||||||||||||||:|||||||||||||:||||||||  |||||| a102VSLTVGQLVFFGILAFCVWASARLVDRFTSVLIGGMVLTFIWATGGLIADAKLPVLFDTQ       130       140       150       160       170       180       190       200       210       220       230       240 m102.pepAPAGTNYWIYAATALPVCLASFGFHGNVSSLLKYFKGDAPKVAKSIWTGTLIALVIYVLW||:|||||||:||||||||||||||||||||||||||||||||||||||||||||||||| a102APTGTNYWIYVATALPVCLASFGFHGNVSSLLKYFKGDAPKVAKSIWTGTLIALVIYVLW       190       200       210       220       230       240       250       260       270       280       290       300 m102.pepQTAIQGNLPRNEFAPVIAAEGQVSVLIETLSKFAQTGNMDKILSLFSYMAIATSFLGVTL |||||||||||||||||||||||| |||||||||||||||||||||||||||||||||| a102QTAIQXNLPRNEFAPVIAAEGQVSVXIETLSKFAQTGNMDKILSLFSYMAIATSFLGVTL       250       260       270       280       290       300       310       320       330       340       350       360 m102.pepGLFDYIADIFKWNDSISGRTKTAALTFLPPLISCLLFPTGFVTAIGYVGLAATVWTGIIP|||||||||||||||:|||||||||||||| ||||||||||||||||||||||||||||| a102GLFDYIADIFKWNDSVSGRTKTAALTFLPPXISCLLFPTGFVTAIGYVGLAATVWTGIIP       310       320       330       340       350       360       370       380       390       400       410 102.pepAMLLYRSRKKFGAGKTYKVYGGLWLMVWVFLFGIVNIAAQVLSQMELVPVFKGX|||||||||||||||||||||||||||||||||| |||| |||||||||||||| a102AMLLYRSRKKFGAGKTYKVYGGLWLMVWVFLFGIXNIAAXVLSQMELVPVFKGX       370       380       390       400       410The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 363>:

g105.seq 1 Atgtccgcag aaaCATACAc acAAAtcggc tGGgtaggct taggGcaaat 51gGgtctgcct atgGTAACGC GGCTCTTGGA CGGCGGCATC GAAGTCGGCG 101TATACAACCG CTCGCCCGAC AAAACTGCCC CCATCTCcgc CAAAGGAGCA 151AAAGTTTACG GCagcACCGC CGAACTCGTC CGCGCCTGCC CCGTCATTTT 201CCTGATGGTT TCCGACTATG CCGCCGTGTG CGACATCCTG AACGGAGTCC 251GCGACGGATT GGCCGGCAAA ATCATCGTCA ACATGAGCAC CATCTCCCCG 301ACCGAAAACC TCGCCGTCAA AGCACTTGTC GAAGCCGCAG GCGGACAGTT 351TGCCGAAGCA CCCGTTTCCG GATCGGTCGG ACCCGCCACC AACGGCACAC 401TGCTGATTCT GTTCGGCGGC AGCGAAGCCG TTTTAAACCC GCTGCAAAAA 451ATATTTTCCC TTGTCGGCAA AAAAACCTTC CATTTCGGCG ATGTCGGCAA 501AGGCTCGGGC GCGAAACTCG TCTTGAACTC GCTCTTAGGC ATTTTCGGCG 551AAGCGTACAG CGAAGCGATG CTGATGGCGC GGCAGTTCGG CATCGATACC 601GACACCATCG TCGAAGCCAT CGGCGGCTCG GCAATGGACT CGCCTATGTT 651TCAAACAAAA AAATCACTAT GGGCAAACCG TGAGTTCCCC CCTGCCTTTG 701CACTCAAACA CGCTTCCAAA GAcctTAACC TCGccgtcAA AGAGCTTGAA 751CAGGCAGGCA ACACCCTGCC CGCCGTCGAA ACCGTTGCTG CCAGCTACCG 801CAAAGCAGTT GAAGCCGGCT ACGGCGAACA GGACGTTTCC GGCGTTTACC 851TGAAATTGGC AGAACACTGAThis corresponds to the amino acid sequence <SEQ ID 364; ORF 105.ng>:

g105.pep 1 MSAETYTQIG WVGLGQMGLP MVTRLLDGGI EVGVYNRSPD KTAPISAKGA 51KVYGSTAELV RACPVIFLMV SDYAAVCDIL NGVRDGLAGK IIVNMSTISP 101TENLAVKALV EAAGGQFAEA PVSGSVGPAT NGTLLILFGG SEAVLNPLQK 151IFSLVGKKTF HFGDVGKGSG AKLVLNSLLG IFGEAYSEAM LMARQFGIDT 201DTIVEAIGGS AMDSPMFQTK KSLWANREFP PAFALKHASK DLNLAVKELE 251QAGNTLPAVE TVAASYRKAV EAGYGEQDVS GVYLKLAEHThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 365>:

m105.seq 1 ATGTCCGCAA ACGAATACGC ACAAATCGGC TGGaTAGGCT TAGGGCAAAT 51GGGTCTGCCT ATGGTAACGC GGCTCTTGGA CGGCGGCATC GAAGTCGGCG 101TATACAACCG CTCGCCCGAC AAAACTGCCC CCATCTCCGC CAAAGGCGCA 151AAAGTTTACG GCAACACCGC CGAACTCGTC CGCGACTATC CCGTCATTTT 201CCTGATGGTT TCCGACTATG CCGCCGTGTG CGACATCCTG AACGGAGTCC 251GCGACGGATT GGCCGGCAAm ATCATCGTCA ACATGAGCAC CATCTCCCCG 301ACCGAAAaGC TCGCCGTCAA AGCACTTGTC GAAGCGCAGm GaCAGTTTGC 351CGAAGCACCC GTTTCCGGAT CGGTCGGGCC CGCCACCAAC GGCACGCTGC 401TGATTCTGTT CGGCGGCAGC GAAcCGtTTT AAACCCGCTG CAAAAAATAT 451TTTCCCTCGT CGGCAAAAAA ACCTTCCATT TCGGCGATGT CGGCAAAGGT 501TCGGGCGCGA AACTCGTCTT GAACTCGCTC TTGGGCATTT TCGGCGAaCG 551TAcAGCGAAs GmTgCTGATG GCGCGGCAGT TCGGCATCGA TACCGACACC 601ATCGTCGAAG CCATCGGsGA CTCGGCAATG GACTCGCCCA TGTTCCAAAC 651CAAAAAATCC CTGTGGGCAA ACCGCGAATT CCCGmCCGmC TTCGCCCTCA 701AACACGCCTC CAAAGACCTC AACCTCGCCG TCAAAGAGCT TGAACAGGCA 751GGCAACACCC TGCCCGCCGT CGAAACCGTT GCTGCCAGCT ACCGCAAAGC 801AGTCGAAGCC GGCTACGGGA CACAGGACGT TTCCGGCGTT TACCTGAAAC 851TGGCAGAACA CTGAThis corresponds to the amino acid sequence <SEQ ID 366; ORF 105>:

m105.pep 1 MSANEYAQIG WIGLGQMGLP MVTRLLDGGI EVGVYNRSPD KTAPISAKGA 51KVYGNTAELV RDYPVIFLMV SDYAAVCDIL NGVRDGLAGX IIVNMSTISP 101TEKLAVKALV EAQRQFAEAP VSGSVGPATN GTLLILFGGS EPFXTRCKKY 151FPSSAKKPSI SAMSAKVRAR NSSXTRSWAF SANVQRXXLM ARQFGIDTDT 201IVEAIGDSAM DSPMFQTKKS LWANREFPXX FALKHASKDL NLAVKELEQA 251GNTLPAVETV AASYRKAVEA GYGTQDVSGV YLKLAEHComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 105 shows 79.9% identity over a 289 aa overlap with a predicted ORF(ORF 105.ng) from N. gonorrhoeae:

m105/g105           10        20        30        40        50        60g105.pep   MSAETYTQIGWVGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGSTAELV  |||: |:||||:||||||||||||||||||||||||||||||||||||||||||:||||| m105  MSANEYAQIGWIGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGNTAELV          10        20        30        40        50        60          70        80        90       100       110       120 g105.pep  RACPVIFLMVSDYAAVCDILNGVRDGLAGKIIVNMSTISPTENLAVKALVEAAGGQFAEA   | |||||||||||||||||||||||||| ||||||||||||:|||||||||   ||||| m105  RDYPVIFLMVSDYAAVCDILNGVRDGLAGXIIVNMSTISPTEKLAVKALVEAQR-QFAEA          70        80        90       100       110         130       140       150       160       170       180 g105.pep  PVSGSVGPATNGTLLILFGGSEAVLNPLQKIFSLVGKKTFHFGDVGKGSGAKLVLNSLLG  ||||||||||||||||||||||   :  :| |   :||   :: ::    |:    : m105  PVSGSVGPATNGTLLILFGGSEPFXTRCKKYFPSSAKKP-SISAMSAKVRARNSSXTRSW120       130       140       150        160       170        190       200       210       220       230       240 g105.pep IFGEAYSEAMLMARQFGIDTDTIVEAIGGSAMDSPMFQTKKSLWANREFPPAFALKHASK  |:   ::  |||||||||||||||||| |||||||||||||||||||||  |||||||| m105 AFSANVQRXXLMARQFGIDTDTIVEAIGDSAMDSPMFQTKKSLWANREFPXXFALKHASK180       190       200       210       220       230        250       260       270       280      289 g105.pep DLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGVYLKLAEH ||||||||||||||||||||||||||||||||||| ||||||||||||| m105 DLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGTQDVSGVYLKLAEH240       250       260       270       280The following partial DNA sequence was identified in N. meningitidis<SEQ ID 367>:

a105.seq 1 ATGTCCGCAA ACGAATACAC ACAAATCGGC TGGATAGGCT TAGGGCAAAT 51GGGTCTGCCT ATGGTAACGC GGCTCTTGGA CGGCGGCATC GAAGTCGGCG 101TATACAACCG CTCGCCCGAC AAAACTGCCC CCATCTCCGC CAAAGGCGCA 151AAAGTTTACG GCAACACCGC CGAACTCGTC CGCGACTATC CCGTCATTTT 201CCTGATGGTT TCCGACTATG CCGCCGTGTG CGACATCCTG AACGGAGTCC 251GCGACGGATT GGCCGGCAAA ATCATCGTCA ACATGAGCAC CATCTCCCCG 301ACCGAAAACC TCGCCGTCAA AGCACTTGTC GAAGCCGCAG GCGGACAGTT 351TGCCGAAGCA CCCGTTTCCG GATCGGTCGG GCCCGCCACC AACGGCACGC 401TGCTGATTCT GTTCGGCGGC AGCGAAGCCG TTTTAAACCC GCTGCAAAAA 451ATATTTTCCC TCGTCGGCAA AAAAACCTTC CATTTCGGCG ATGTCGGCAA 501AGGTTCGGGC GCGAAACTCG TCTTGAACTC GCTCTTGGGC ATTTTCGGCG 551AAGCGTACAG CGAAGCGATG CTGATGGCGC GGCAGTTCGG CATCGATACC 601GACACCATCG TCGAAGCCAT CGGCGGCTCG GCAATGGACT CGCCCATGTT 651CCAAACCAAA AAATCCCTGT GGGCAAACCG CGAATTCCCA CCCGCCTTCG 701CCCTCAAACA CGCCTCCAAA GACCTCAACC TCGCCGTCAA AGAGCTTGAA 751CAGGCAGGCA ACACCCTGCC CGCCGTCGAA ACCGTTGCTG CCAGCTACCG 801CAAAGCAGTC GAAGCCGGCT ACGGCGAACA GGACGTTTCC GGCGTTTACC 851TGAAATTGGC AGAACACTGAThis corresponds to the amino acid sequence <SEQ ID 368; ORF 105.a>:

a105.pep 1 MSANEYTQIG WIGLGQMGLP MVTRLLDGGI EVGVYNRSPD KTAPISAKGA 51KVYGNTAELV RDYPVIFLMV SDYAAVCDIL NGVRDGLAGK IIVNMSTISP 101TENLAVKALV EAAGGQFAEA PVSGSVGPAT NGTLLILFGG SEAVLNPLQK 151IFSLVGKKTF HFGDVGKGSG AKLVLNSLLG IFGEAYSEAM LMARQFGIDT 201DTIVEAIGGS AMDSPMFQTK KSLWANREFP PAFALKHASK DLNLAVKELE 251QAGNTLPAVE TVAASYRKAV EAGYGEQDVS GVYLKLAEH* m105/a10596.5% identity in 289 aa overlap          10        20        30        40        50        60 m105.pep  MSANEYAQIGWIGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGNTAELV  ||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||| a105  MSANEYTQIGWIGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGNTAELV          10        20        30        40        50        60          70        80        90       100       110       119 m105.pep  RDYPVIFLMVSDYAAVCDILNGVRDGLAGKIIVNMSTISPTENLAVKALVEAAG-QFAEA  |||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||| a105  RDYPVIFLMVSDYAAVCDILNGVRDGLAGKIIVNMSTISPTENLAVKALVEAAGGQFAEA          70        80        90       100       110       120120       130       140       150       160       170      179 m105.pep  PVSGSVGPATNGTLLILFGGSEAVLNPLQKIFSLVGKKTFHFGDVGKGSGAKLVLNSLLG  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a105  PVSGSVGPATNGTLLILFGGSEAVLNPLQKIFSLVGKKTFHFGDVGKGSGAKLVLNSLLG         130       140       150       160       170       180180        190       200       210       220       230 m105.pep  IFGDV-QRXMLMARQFGIDTDTIVEAIGDSAMDSPMFQTKKSLWANREFPXAFALKHASK  |||:: :: ||||||||||||||||||| ||||||||||||||||||||| ||||||||| a105  IFGEAYSEAMLMARQFGIDTDTIVEAIGGSAMDSPMFQTKKSLWANREFPPAFALKHASK         190       200       210       220       230       240240       250       260       270       280 m105.pep DLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGVYLKLAEHX |||||||||||||||||||||||||||||||||||||||||||||||||| a105 DLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGVYLKLAEHX        250       260       270       280       290The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 369>:

g105-1.seq 1 ATGTCCGCAG AAACATACAC ACAAATCGGC TGGGTAGGCT TAGGGCAAAT 51GGGTCTGCCT ATGGTAACGC GGCTCTTGGA CGGCGGCATC GAAGTCGGCG 101TATACAACCG CTCGCCCGAC AAAACTGCCC CCATCTCCGC CAAAGGAGCA 151AAAGTTTACG GCAGCACCGC CGAACTCGTC CGCGCCTGCC CCGTCATTTT 201CCTGATGGTT TCCGACTATG CCGCCGTGTG CGACATCCTG AACGGAGTCC 251GCGACGGATT GGCCGGCAAA ATCATCGTCA ACATGAGCAC CATCTCCCCG 301ACCGAAAACC TCGCCGTCAA AGCACTTGTC GAAGCCGCAG GCGGACAGTT 351TGCCGAAGCA CCCGTTTCCG GATCGGTCGG ACCCGCCACC AACGGCACAC 401TGCTGATTCT GTTCGGCGGC AGCGAAGCCG TTTTAAACCC GCTGCAAAAA 451ATATTTTCCC TTGTCGGCAA AAAAACCTTC CATTTCGGCG ATGTCGGCAA 501AGGCTCGGGC GCGAAACTCG TCTTGAACTC GCTCTTAGGC ATTTTCGGCG 551AAGCGTACAG CGAAGCGATG CTGATGGCGC GGCAGTTCGG CATCGATACC 601GACACCATCG TCGAAGCCAT CGGCGGCTCG GCAATGGACT CGCCTATGTT 651TCAAACAAAA AAATCACTAT GGGCAAACCG TGAGTTCCCC CCTGCCTTTG 701CACTCAAACA CGCTTCCAAA GACCTTAACC TCGCCGTCAA AGAGCTTGAA 751CAGGCAGGCA ACACCCTGCC CGCCGTCGAA ACCGTTGCTG CCAGCTACCG 801CAAAGCAGTT GAAGCCGGCT ACGGCGAACA GGACGTTTCC GGCGTTTACC 851TGAAATTGGC AGAACACTGAThis corresponds to the amino acid sequence <SEQ ID 370; ORF 105-1.ng>:

g105-1.pep 1 MSAETYTQIG WVGLGQMGLP MVTRLLDGGI EVGVYNRSPD KTAPISAKGA 51KVYGSTAELV RACPVIFLMV SDYAAVCDIL NGVRDGLAGK IIVNMSTISP 101TENLAVKALV EAAGGQFAEA PVSGSVGPAT NGTLLILFGG SEAVLNPLQK 151IFSLVGKKTF HFGDVGKGSG AKLVLNSLLG IFGEAYSEAM LMARQFGIDT 201DTIVEAIGGS AMDSPMFQTK KSLWANREFP PAFALKHASK DLNLAVKELE 251QAGNTLPAVE TVAASYRKAV EAGYGEQDVS GVYLKLAEH*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 371>:

m105-1.seq 1 ATGTCCGCAA ACGAATACGC ACAAATCGGC TGGATAGGCT TAGGGCAAAT 51GGGTCTGCCT ATGGTAACGC GGCTCTTGGA CGGCGGCATC GAAGTCGGCG 101TATACAACCG CTCGCCCGAC AAAACTGCCC CCATCTCCGC CAAAGGCGCA 151AAAGTTTACG GCAACACCGC CGAACTCGTC CGCGACTATC CCGTCATTTT 201CCTGATGGTT TCCGACTATG CCGCCGTGTG CGACATCCTG AACGGAGTCC 251GCGACGGATT GGCCGGCAAA ATCATCGTCA ACATGAGCAC CATCTCCCCG 301ACCGAAAACC TCGCCGTCAA AGCACTTGTC GAAGCCGCAG GCGGACAGTT 351TGCCGAAGCA CCCGTTTCCG GATCGGTCGG GCCCGCCACC AACGGCACGC 401TGCTGATTCT GTTCGGCGGC AGCGAAGCcG TTTTAAACCC GCTGCAAAAA 451ATATTTTCCC TCGTCGGCAA AAAAACCTTC CATTTCGGCG ATGTCGGCAA 501AGGTTCGGGC GCGAAACTCG TCTTGAACTC GCTCTTGGGC ATTTTCGGCG 551AAGCGTACAG CGAAnCGATG CTGATGGCGC GGCAGTTCGG CATCGATACC 601GACACCATCG TCGAAGCCAT CGGsGACTCG GCAATGGACT CGCCCATGTT 651CCAAACCAAA AAATCCCTGT GGGCAAACCG CGAATTCCCG CCCGCCTTCG 701CCCTCAAACA CGCCTCCAAA GACCTCAACC TCGCCGTCAA AGAGCTTGAA 751CAGGCAGGCA ACACCCTGCC CGCCGTCGAA ACCGTTGCTG CCAGCTACCG 801CAAAGCAGTC GAAGCCGGCT ACGGCGAACA GGACGTTTCC GGCGTTTACC 851TGAAACTGGC AGAACACTGAThis corresponds to the amino acid sequence <SEQ ID 372; ORF 105-1>:

m105-1.pep 1 MSANEYAQIG WIGLGQMGLP MVTRLLDGGI EVGVYNRSPD KTAPISAKGA 51KVYGNTAELV RDYPVIFLMV SDYAAVCDIL NGVRDGLAGK IIVNMSTISP 101TENLAVKALV EAAGGQFAEA PVSGSVGPAT NGTLLILFGG SEAVLNPLQK 151IFSLVGKKTF HFGDVGKGSG AKLVLNSLLG IFGEAYSEXM LMARQFGIDT 201DTIVEAIGDS AMDSPMFQTK KSLWANREFP PAFALKHASK DLNLAVKELE 251QAGNTLPAVE TVAASYRKAV EAGYGEQDVS GVYLKLAEH* m105-1/g105-196.9% identity in 289 aa overlap        10        20        30        40        50        60 m105-1.pepMSANEYAQIGWIGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGNTAELV|||: |:||||:||||||||||||||||||||||||||||||||||||||||||:||||| g105-1MSAETYTQIGWVGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGSTAELV        10        20        30        40        50        60        70        80        90       100       110       120 m105-1.pepRDYPVIFLMVSDYAAVCDILNGVRDGLAGKIIVNMSTISPTENLAVKALVEAAGGQFAEA | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g105-1RACPVIFLMVSDYAAVCDILNGVRDGLAGKIIVNMSTISPTENLAVKALVEAAGGQFAEA        70        80        90       100       110       120       130       140       150       160       170       180 m105-1.pepPVSGSVGPATNGTLLILFGGSEAVLNPLQKIFSLVGKKTFHFGDVGKGSGAKLVLNSLLG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g105-1PVSGSVGPATNGTLLILFGGSEAVLNPLQKIFSLVGKKTFHFGDVGKGSGAKLVLNSLLG       130       140       150       160       170       180       190       200       210       220       230       240 m105-1.pepIFGEAYSEXMLMARQFGIDTDTIVEAIGDSAMDSPMFQTKKSLWANREFPPAFALKHASK ||||||||||||||||||||||||||| ||||||||||||||||||||||||||||||| g105-1IFGEAYSEAMLMARQFGIDTDTIVEAIGGSAMDSPMFQTKKSLWANREFPPAFALKHASK       190       200       210       220       230       240       250       260       270       280       290 m105-1.pepDLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGVYLKLAEHX|||||||||||||||||||||||||||||||||||||||||||||||||| g105-1DLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGVYLKLAEHX       250       260       270       280       290The following partial DNA sequence was identified in N. meningitidis<SEQ ID 373>:

a105-1.seq 1 ATGTCCGCAA ACGAATACAC ACAAATCGGC TGGATAGGCT TAGGGCAAAT 51GGGTCTGCCT ATGGTAACGC GGCTCTTGGA CGGCGGCATC GAAGTCGGCG 101TATACAACCG CTCGCCCGAC AAAACTGCCC CCATCTCCGC CAAAGGCGCA 151AAAGTTTACG GCAACACCGC CGAACTCGTC CGCGACTATC CCGTCATTTT 201CCTGATGGTT TCCGACTATG CCGCCGTGTG CGACATCCTG AACGGAGTCC 251GCGACGGATT GGCCGGCAAA ATCATCGTCA ACATGAGCAC CATCTCCCCG 301ACCGAAAACC TCGCCGTCAA AGCACTTGTC GAAGCCGCAG GCGGACAGTT 351TGCCGAAGCA CCCGTTTCCG GATCGGTCGG GCCCGCCACC AACGGCACGC 401TGCTGATTCT GTTCGGCGGC AGCGAAGCCG TTTTAAACCC GCTGCAAAAA 451ATATTTTCCC TCGTCGGCAA AAAAACCTTC CATTTCGGCG ATGTCGGCAA 501AGGTTCGGGC GCGAAACTCG TCTTGAACTC GCTCTTGGGC ATTTTCGGCG 551AAGCGTACAG CGAAGCGATG CTGATGGCGC GGCAGTTCGG CATCGATACC 601GACACCATCG TCGAAGCCAT CGGCGGCTCG GCAATGGACT CGCCCATGTT 651CCAAACCAAA AAATCCCTGT GGGCAAACCG CGAATTCCCA CCCGCCTTCG 701CCCTCAAACA CGCCTCCAAA GACCTCAACC TCGCCGTCAA AGAGCTTGAA 751CAGGCAGGCA ACACCCTGCC CGCCGTCGAA ACCGTTGCTG CCAGCTACCG 801CAAAGCAGTC GAAGCCGGCT ACGGCGAACA GGACGTTTCC GGCGTTTACC 851TGAAATTGGC AGAACACTGAThis corresponds to the amino acid sequence <SEQ ID 374; ORF 105-1.a>:

a105-1.pep 1 MSANEYTQIG WIGLGQMGLP MVTRLLDGGI EVGVYNRSPD KTAPISAKGA 51KVYGNTAELV RDYPVIFLMV SDYAAVCDIL NGVRDGLAGK IIVNMSTISP 101TENLAVKALV EAAGGQFAEA PVSGSVGPAT NGTLLILFGG SEAVLNPLQK 151IFSLVGKKTF HFGDVGKGSG AKLVLNSLLG IFGEAYSEAM LMARQFGIDT 201DTIVEAIGGS AMDSPMFQTK KSLWANREFP PAFALKHASK DLNLAVKELE 251QAGNTLPAVE TVAASYRKAV EAGYGEQDVS GVYLKLAEH* a105-1/m105-199.0% identity in 289 aa overlap        10        20        30        40        50        60 a105-1.pepMSANEYTQIGWIGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGNTAELV||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||| m105-1MSANEYAQIGWIGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGNTAELV        10        20        30        40        50        60        70        80        90       100       110       120 a105-1.pepRDYPVIFLMVSDYAAVCDILNGVRDGLAGKIIVNMSTISPTENLAVKALVEAAGGQFAEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m105-1RDYPVIFLMVSDYAAVCDILNGVRDGLAGKIIVNMSTISPTENLAVKALVEAAGGQFAEA        70        80        90       100       110       120       130       140       150       160       170       180 a105-1.pepPVSGSVGPATNGTLLILFGGSEAVLNPLQKIFSLVGKKTFHFGDVGKGSGAKLVLNSLLG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m105-1PVSGSVGPATNGTLLILFGGSEAVLNPLQKIFSLVGKKTFHFGDVGKGSGAKLVLNSLLG       130       140       150       160       170       180       190       200       210       220       230       240 a105-1.pepIFGEAYSEAMLMARQFGIDTDTIVEAIGGSAMDSPMFQTKKSLWANREFPPAFALKHASK ||||||||||||||||||||||||||| ||||||||||||||||||||||||||||||| m105-1IFGEAYSEXMLMARQFGIDTDTIVEAIGDSAMDSPMFQTKKSLWANREFPPAFALKHASK       190       200       210       220       230       240       250       260       270       280       290 a105-1.pepDLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGVYLKLAEHX|||||||||||||||||||||||||||||||||||||||||||||||||| m105-1DLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGVYLKLAEHX       250       260       270       280       290The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 375>:

g107.seq 1 ATGGTATTAA CCTTTATTTG GGCAACCGGC GGCCTGGTTG CCGATGCCAA 51ACCGTCCGTC CTCTTCGACA CCCAAGCCCC CGTCGGCACC GGCTACTGGA 101TTTACGCCGC CACCGCCCTG CCCGTCTGCC TCGCTTCCTT CGGCTTCCAC 151GGCAACGTTT CCAGCCTGCT CAAATACTTT AAAGGCGACG cgcCcaaagt 201GgCGAaATCc atctggGcag gtacattggT TGCCttggta atttacgtcc 251TCTggcaaac cgccatCcaa agcaaccTGC cgcgcaacga gttcgcCCCc 301gtgattgccg ccgagaggca actCTCCGTC CTgaatgaaa cccTGtccaa 351attcgcccaa accggcgata tggataAaat attgtcccta tttccctaca 401tggcaatcgc cacctccttt ttaggcgTAA Ccttaggcct gtttgacaac 451atcgccggac atcttcaaat ggaacgacag tatgtccggg cggcaccaaa 501accgtcgcgc tgaThis corresponds to the amino acid sequence <SEQ ID 376; ORF 107.ng>:

g107.pep 1 MVLTFIWATG GLVADAKPSV LFDTQAPVGT GYWIYAATAL PVCLASFGFH 51GNVSSLLKYF KGDAPKVAKS IWAGTLVALV IYVLWQTAIQ SNLPRNEFAP 101VIAAERQLSV LNETLSKFAQ TGDMDKILSL FPYMAIATSF LGVTLGLFDN 151IAGHLQMERQ YVRAAPKPSR *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 377>:

m107.seq 1 ATGGTATTGA CCTTTATTTG GGCGGCCGGC GGGCTGATTG CCGATGCCAA 51GCCGTCCGTC CTCTTCGATA CCCAAGCCCC CGCCGGCACA AACTACTGGA 101TTTACGCCGs CACCGCCCTG CCCGTCTGCC TCGCTTCCTT CGGCTTCCAC 151GGCAACGTCT CCAGCCTGCT CAAATACTTT AAAGGCGACG CGCCCAAAGT 201GGCTAAATCC ATCTGGACGG GCACACTGAT TGCGCTGGTA ATTTACGTCC 251TCTGGCAAAC CGCCATCCAA GGCAACCTGC CGCGCAACGA GTTCGCCCCC 301GTCATCGCCG CCGAAGGGCA AGTCTCCGTC CTCATCGAAA CCCTGTCCAA 351ATTCGCCCAA ACCGGCAATA TGGACAAAAT ATTGTCCCTG TTTTCCTATA 401TGGCGATCGC CACCTCGTTT TTAGGCGTAA CGCTCGGACT CTTCGACTAC 451ATCGCCCATC TTCAAATGGA ACGACAGCAT CTCCGGgCCG CACCAAAACC 501 GCCGCGCTGAThis corresponds to the amino acid sequence <SEQ ID 378; ORF 107>:

m107.pep.. 1 MVLTFIWAAG GLIADAKPSV LFDTQAPAGT NYWIYAXTAL PVCLASFGFH 51GNVSSLLKYF KGDAPKVAKS IWTGTLIALV IYVLWQTAIQ GNLPRNEFAP 101VIAAEGQVSV LIETLSKFAQ TGNMDKILSL FSYMAIATSF LGVTLGLFDY 151IAHLQMERQH LRAAPKPPR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 107 shows 89.4% identity over a 170 aa overlap with a predicted ORF(ORF 107.ng) from N. gonorrhoeae:

m107/g107         10        20        30        40        50        60m107.pep MVLTFIWAAGGLIADAKPSVLFDTQAPAGTNYWIYAXTALPVCLASFGFHGNVSSLLKYF||||||||:|||:||||||||||||||:||:||||| ||||||||||||||||||||||| g107MVLTFIWATGGLVADAKPSVLFDTQAPVGTGYWIYAATALPVCLASFGFHGNVSSLLKYF        10        20        30        40        50        60        70        80        90       100       110       120 m107.pepKGDAPKVAKSIWTGTLIALVIYVLWQTAIQGNLPRNEFAPVIAAEGQVSVLIETLSKFAQ||||||||||||:|||:|||||||||||||:|||||||||||||| |:||| |||||||| g107KGDAPKVAKSIWAGTLVALVIYVLWQTAIQSNLPRNEFAPVIAAERQLSVLNETLSKFAQ        70        80        90       100       110       120       130       140       150        160       170 m107.pepTGNMDKILSLFSYMAIATSFLGVTLGLFDYIA-HLQMERQHLRAAPKPPR ||:||||||||||||||||||||||||| || |||||||::|||||| | g107TGDMDKILSLFPYMAIATSFLGVTLGLFDNIAGHLQMERQYVRAAPKPSR       130       140       150       160       170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 379>:

a107.seq 1 ATGGTATTAA CCTTTATTTG GGCAACCGGC GGCCTGATTG CCGATGCCAA 51ACTGCCCGTC CTCTTCGACA CCCAAGCCCC TACCGGCACC AACTACTGGA 101TTTATGTCGC CACCGCCCTG CCCGTCTGCC TTGCGTCATT CGGTTTCCAC 151GGCAACGTCT CCAGCCTGCT CAAATACTTT AAAGGCGACG CGCCCAAAGT 201GGCTAAATCC ATCTGGACGG GCACACTGAT TGCGCTGGTA ATTTACGTCC 251TCTGGCAAAC CGCCATCCAA GGCAACCTGC CGCGCAACGA GTTCGCCCCC 301GTGATTGCCG CCGAAGGGCA AGTCTCCGTC CTGATTGAAA CCCTGTCCAA 351ATTCGCCCAA ACCGGCAATA TGGACAAAAT ATTGTCCCTG TTTTCCTATA 401TGGCGATCGC CACCTCGTTT TTAGGCGTAA CGCTCGGACT CTTCGACTAC 451ATCGCCGACA TCTTCAAATG GAACGACAGC GTGTCCGGCC GCACCAAAAC 501CGCCGCGCTG ACCTTCCTGC CGCCTCTAAT TTCCTGCCTG CTCTTCCCCA 551CCGGCTTTGT TACCGCCATC GGCTACGTCG GCCTGGCGGC AACCGTCTGG 601ACAGGCATCA TCCCCGCCAT GCTGCTCTAC CGTTCGCGCA AAAAATTCGG 651CGCAGGCAAA ACCTATAAAG TTTACGGCGG CTTGTGGCTG ATGGTTTGGG 701TCTTCCTTTT CGGCATCGTC AACATCGCCG CACAGGTATT GAGCCAAATG 751GAACTCGTCC CCGTATTTAA AGGATAAThis corresponds to the amino acid sequence <SEQ ID 380; ORF 107.a>:

a107.pep 1 MVLTFIWATG GLIADAKLPV LFDTQAPTGT NYWIYVATAL PVCLASFGFH 51GNVSSLLKYF KGDAPKVAKS IWTGTLIALV IYVLWQTAIQ GNLPRNEFAP 101VIAAEGQVSV LIETLSKFAQ TGNMDKILSL FSYMAIATSF LGVTLGLFDY 151IADIFKWNDS VSGRTKTAAL TFLPPLISCL LFPTGFVTAI GYVGLAATVW 201TGIIPAMLLY RSRKKFGAGK TYKVYGGLWL MVWVFLFGIV NIAAQVLSQM 251 ELVPVFKG*m107/a107 94.8% identity in 154 aa overlap        10        20        30        40        50        60 m107.pepMVLTFIWAAGGLIADAKPSVLFDTQAPAGTNYWIYAXTALPVCLASFGFHGNVSSLLKYF||||||||:||||||||  ||||||||:|||||||: ||||||||||||||||||||||| a107MVLTFIWATGGLIADAKLPVLFDTQAPTGTNYWIYVATALPVCLASFGFHGNVSSLLKYF        10        20        30        40        50        60        70        80        90       100       110       120 m107.pepKGDAPKVAKSIWTGTLIALVIYVLWQTAIQGNLPRNEFAPVIAAEGQVSVLIETLSKFAQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a107KGDAPKVAKSIWTGTLIALVIYVLWQTAIQGNLPRNEFAPVIAAEGQVSVLIETLSKFAQ        70        80        90       100       110       120       130       140       150       160       170 m107.pepTGNMDKILSLFSYMAIATSFLGVTLGLFDYIAHLQMERQHLRAAPKPPRX|||||||||||||||||||||||||||||||| : al07TGNMDKILSLFSYMAIATSFLGVTLGLFDYIADIFKWNDSVSGRTKTAALTFLPPLISCL       130       140       150       160       170       180 a107LFPIGFVTAIGYVGLAATVWTGIIPAMLLYRSRKKFGAGKTYKVYGGLWLMVWVFLFGIV       190       200       210       220       230       240The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 381>:

g108.seq 1 ATGttgccgg gCTTCAACCG GATATTCAaa cggTTTGCTC CAACACTCGG 51AAcggCGCAT AAAACGCCgc ccTTCGCGTT ATCCCGAACG GGGCGGCTAA 101TCAGATCCTA TCGCCATAAA AGGCGGGGTT TCAACCGAAA AGGAATTGAG 151ATGAATAAAA CCTTGTCTAT TTTGCCGGCG GCAATCTTAC TCGGCGGGTG 201CGCCGCCGGC GGCAACACAT TCGGCAGCTT AGACGGCGGC ACGGGTATGG 251GTGGCAGCAT CGTCAAAATG ACGGTAGAAA gccAATGCCG TGCGGAATTG 301GACAGGCGCA GCGAATGGCG TTTGACCGCG CTGGCGATGA GTGCCGAAAA 351ACAGGCGGAA TGGGAAAACA AGATTTGCGG CTGCGCTACC GAAGAAGCAC 401CTAACCAGCT GACCGGCAAC GATGTGATGC AGATGCTGAa ccagtccacG 451CGCaatcagg cacTtgccgc CCtgaccgTC AAAacggtTT CcgcctgcTT 501CAaacgcctg tACCGCTAaThis corresponds to the amino acid sequence <SEQ ID 382; ORF 108.ng>:

g108.pep 1 MLPGFNRIFK RFAPTLGTAH KTPPFALSRT GRLIRSYRHK RRGFNRKGIE 51MNKTLSILPA AILLGGCAAG GNTFGSLDGG TGMGGSIVKM TVESQCRAEL 101DRRSEWRLTA LAMSAEKQAE WENKICGCAT EEAPNQLTGN DVMQMLNQST 151RNQALAALTV KTVSACFKRL YR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 383>:

m108.seq 1 ATGTTGCCGG GCTTCAACCG GATATTCAAA CGGTTTGTTC CAACACTCGG 51AACGGCGCAT AAAACGCCGC CCTTCGCGTT ATCCCGAACG GGGCGGCTAA 101TCAGATTCTA TCGCCATAAA AGGCGGGGTT TCAACCGAAA AGGAATTGAG 151ATGAATAAAA CCTTGTCTAT TTTGCCGGTG GCAATCTTAC TCGGCGGCTG 201CGCCGCCGGA GGCGGTAACA CATTCGGCAG CTTAGACGGT GGCACAGGCA 251TGGGCGGCAG CATCGTCAAA ATGGCGGTTG GGAGCCAATG CCGTGCGGAA 301TTGGACAAAC GCAGCGAATG GCGTTTGACC GCGCTGGCGA TGAGTGCCGA 351AAAACAGGCG GAGTGGGAAA ACAAGATTTG CGCTTGCGTC GCCCAAGAAG 401CACCCGAACG GATGACCGGC AACGATGTGA TGCAGATGCT GGCTCCGTCC 451ACGCGCAATC AGGCACTTGC CGCCCTGACC GCCAAAACGG TTTCCGCCTG 501CTTCAAACAC CTGTACCGCT AAThis corresponds to the amino acid sequence <SEQ ID 384; ORF 108>:

m108.pep 1 MLPGFNRIFK RFVPTLGTAH KTPPFALSRT GRLIRFYRHK RRGFNRKGIE 51MNKTLSILPV AILLGGCAAG GGNTFGSLDG GTGMGGSIVK MAVGSQCRAE 101LDKRSEWRLT ALAMSAEKQA EWENKICACV AQEAPERMTG NDVMQMLAPS 151TRNQALAALT AKTVSACFKH LYR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 108 shows 89.6% identity over a 173 aa overlap with a predicted ORF(ORF 108.ng) from N. gonorrhoeae:

m108/g108           10        20        30        40        50        60m108.pep   MLPGFNRIFKRFVPTLGTAHKTPPFALSRTGRLIRFYRHKRRGFNRKGIEMNKTLSILPV  ||||||||||||:|||||||||||||||||||||| |||||||||||||||||||||||: g108  MLPGFNRIFKRFAPTLGTAHKTPPFALSRTGRLIRSYRHKRRGFNRKGIEMNKTLSILPA          10        20        30        40        50        60          70        80        90       100       110       120 m108.pep  AILLGGCAAGGGNTFGSLDGGTGMGGSIVKMAVGSQCRAELDKRSEWRLTALAMSAEKQA  ||||||||||| |||||||||||||||||||:| ||||||||:||||||||||||||||| g108  AILLGGCAAGG-NTFGSLDGGTGMGGSIVKMTVESQCRAELDRRSEWRLTALAMSAEKQA          70        80        90       100       110         130       140       150       160       170 m108.pep  EWENKICACVAQEAPERMTGNDVMQMLAPSTRNQALAALTAKTVSACFKHLYRX  |||||||:|:::|||:::|||||||||  |||||||||||:||||||||:||| g108  EWENKICGCATEEAPNQLTGNDVMQMLNQSTRNQALAALTVKTVSACFKRLYRX         130       140       150       160       170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 385>:

a108.seq 1 ATGTTGCCGG GCTTCAACCG GATATTCAAA CGGTTTGTTC CAACACTCGG 51AACGGCGCAT AAAACGCCGC CCTTCGCGTT ATCCCGAACG GGGCGGCTAA 101TCAGATTCTA TCGCCATAAA AGGCGGGGTT TCAACCGAAA AGGAATTGAG 151ATGAATAAAA CCTTGTCTAT TTTGCCGGTG GCAATCTTAC TCGGCGGCTG 201CGCCGCCGGG GGCGGTAACA CATTCGGCAG CTTAGACGGC GGCACAGGTA 251TGGGCGGCAG CATCGTCAAA ATGGCGGTAG AAAGCCAATG CCGTGCGGAA 301TTGAACAAAC GCAGCGAATG GCGTTTGACC GCGCTGGCGA TGAGTGCCGA 351AAAACAGGCG GAATGGGAAA ACAAGATTTG CGCTTGCGTC GCCCAAGAAG 401CACCCAACCA GCTGACCGGC AACGATGTGA TGCAGATGCT GGATCCGTCC 451ACGCGCAATC AGGCACTTGC CGCCCTGACC GCCAAAACGG TTTCCGCCTG 501CTTCAAACAC CTGTACCGCT AAThis corresponds to the amino acid sequence <SEQ ID 386; ORF 108.a>:

a108.pep 1 MLPGFNRIFK RFVPTLGTAH KTPPFALSRT GRLIRFYRHK RRGFNRKGIE 51MNKTLSILPV AILLGGCAAG GGNTFGSLDG GTGMGGSIVK MAVESQCRAE 101 LNKRSEWRLTALAMSAEKQA EWENKICACV AQEAPNQLTG NDVMQMLDPS 151 TRNQALAALT AKTVSACFKHLYR* m108/a108 96.5% identity in 173 aa overlap        10        20        30        40        50        60 m108.pepMLPGFNRIFKRFVPTLGTAHKTPPFALSRTGRLIRFYRHKRRGFNRKGIEMNKTLSILPV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a108MLPGFNRIFKRFVPTLGTAHKTPPFALSRTGRLIRFYRHKRRGFNRKGIEMNKTLSILPV        10        20        30        40        50        60        70        80        90       100       110       120 m108.pepAILLGGCAAGGGNTFGSLDGGTGMGGSIVKMAVGSQCRAELDKRSEWRLTALAMSAEKQA||||||||||||||||||||||||||||||||| |||||||:|||||||||||||||||| a108AILLGGCAAGGGNTFGSLDGGTGMGGSIVKMAVESQCRAELNKRSEWRLTALAMSAEKQA        70        80        90       100       110       120       130       140       150       160       170 m108.pepEWENKICACVAQEAPERMTGNDVMQMLAPSTRNQALAALTAKTVSACFKHLYRX|||||||||||||||:::||||||||| |||||||||||||||||||||||||| a108EWENKICACVAQEAPNQLTGNDVMQMLDPSTRNQALAALTAKTVSACFKHLYRX       130       140       150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 387>:

g109.seq 1 ATGTATTATC GCCGGGTTGT GGGGCTATCC GATGGACTTG GCGATTTGGC 51AGCCGGTATT GATCGTAGGC GTATGCTTAC CGCTTTTGGA AGCGGGCATG 101 GAAATGACGCGCAAAGGCAA AACCACCCAA TCCGCCGCCA TCGTGGTGTT 151 CTCTTCCGTC TGGTCAATCCGGTTTTCGGC TGGGCGTTGA CGATGCTGTT 201 GGATAATTTG GGCTTAATCG GCTGCAAAGAACGCAGCGCG CAATTAGGTT 251 TTGTCGGACG AGTATTGATA CCCGCAGTAG GTTTCTTAATCTTGTGTGTG 301 GCGATGGGTG CGGTCGGGAT GCTGCCCGGT ATCCCTCCGT TTTTGGAGCA351 GTTCAAATCT TTGGGCTAGThis corresponds to the amino acid sequence <SEQ ID 388; ORF 109.ng>:

g109.pep 1 MYYRRVVGLS DGLGDLAAGI DRRRMLTAFG SGHGNDAQRQ NHPIRRHRGV 51LFRLVNPVFG WALTMLLDNL GLIGCKERSA QLGFVGRVLI PAVGFLILCV 101 AMGAVGMLPGIPPFLEQFKS LGThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 389>:

m109.seq 1 ATGTATTATC GCCGGGTTAT GGGGCTATCC GATGGACTTG GCGATTTGGC 51AGCCGGTATT GAGCGTAGCC TTGGTCGTAG GCGTATACTT ACCGCTTTTG 101 GAAGCGGGCATGGAAATGAC GCGCAAAGGC AAAACCACCC AATCCGCCGC 151 CATCGTGGTG TTCTCTTCCGCCTTGTCAAT CCGGTTTTCG GCTGGGCGTT 201 GACGATGCTG TTGGATAATT TGGGCTTAATCGGCTGCAAA GAGCGCAGTG 251 CGCAATTAGG TTTCGCCGGA CGCGTGTTGA TACCCGCAGTAGGTTTCTTG 301 ATCTTGTGTG TGGCGATGGG TGCGGTCGGG ATGCTGCCCG GTATCCCGCC351 GTTTTTGGAA CACTTCAAAT CTTTGGGCTA GThis corresponds to the amino acid sequence <SEQ ID 4; ORF 109>:

m109.pep 1 MYYRRVMGLS DGLGDLAAGI ERSLGRRRIL TAFGSGHGND AQRQNHPIRR 51HRGVLFRLVN PVFGWALTML LDNLGLIGCK ERSAQLGFAG RVLIPAVGFL 101 ILCVAMGAVGMLPGIPPFLE HFKSLG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 109 shows 92.9% identity over a 126 aa overlap with a predicted ORF(ORF 109.ng) from N. gonorrhoeae:

m109/g109         10        20        30        40        50        60m109.pep MYYRRVMGLSDGLGDLAAGIERSLGRRRILTAFGSGHGNDAQRQNHPIRRHRGVLFRLVN||||||:|||||||||||||:|    ||:||||||||||||||||||||||||||||||| g109MYYRRVVGLSDGLGDLAAGIDR----RRMLTAFGSGHGNDAQRQNHPIRRHRGVLFRLVN        10        20            30        40        50        70        80        90       100       110       120 m109.pepPVFGWALTMLLDNLGLIGCKERSAQLGFAGRVLIPAVGFLILCVAMGAVGMLPGIPPFLE||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||| g109PVFGWALTMLLDNLGLIGCKERSAQLGFVGRVLIPAVGFLILCVAMGAVGMLPGIPPFLE  60        70        80        90       100       110 m109.pep HFKSLGX:||||| g109 QFKSLGX  120The following partial DNA sequence was identified in N. meningitidis<SEQ ID 391>:

a109.seq 1 ATGTATTATC GCCGGGTTGT GGGGCTATCC GATGGACTTG GCGATTTGGC 51AGCCGGTATT GAGCGTAGCC TTGGTCGTAG GCGTATACTT ACCGCTTTTG 101 GAAGCGGGCATGGAAATGAC GCGCAAAGGC AAAACCACCC AATCCGCCGC 151 CACCGTGGTG TTCTCTTCCGCTTGGTCAAT CCGGTTTTCG GCTGGGCGTT 201 GACGATGCTG TTGGATAATT TGGGCTTAATCGGCTGCAAA GAGCGCAGCG 251 CGCAATTAGG TTTCACCGGA CGCGTATTGA TACCCGTAGTAGGTTTCTTG 301 ATCTTGTGTG TGGCGATGGG TGCGGTCGGG ATGCTGCCCG GTATCCCGCC351 GTTTTTGGAG CACTTCAAAT CTTTGGGCTA GThis corresponds to the amino acid sequence <SEQ ID 392; ORF 109>:

a109.pep 1 MYYRRVVGLS DGLGDLAAGI ERSLGRRRIL TAFGSGHGND AQRQNHPIRR 51HRGVLFRLVN PVFGWALTML LDNLGLIGCK ERSAQLGFTG RVLIPVVGFL 101 ILCVAMGAVGMLPGIPPFLE HFKSLG* m109/a109 97.6% identity in 126 aa overlap        10        20        30        40        50        60 m109.pepMYYRRVMGLSDGLGDLAAGIERSLGRRRILTAFGSGHGNDAQRQNHPIRRHRGVLFRLVN||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||| a109MYYRRVVGLSDGLGDLAAGIERSLGRRRILTAFGSGHGNDAQRQNHPIRRHRGVLFRLVN        10        20        30        40        50        60        70        80        90       100       110       120 m109.pepPVFGWALTMLLDNLGLIGCKERSAQLGFAGRVLIPAVGFLILCVAMGAVGMLPGIPPFLE||||||||||||||||||||||||||||:||||||:|||||||||||||||||||||||| a109PVFGWALTMLLDNLGLIGCKERSAQLGFTGRVLIPVVGFLILCVAMGAVGMLPGIPPFLE        70        80        90       100       110       120 m109.pepHFKSLGX ||||||| a109 HFKSLGXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 393>:

g111.seq 1 ATGCCGTCTG AAACACGCCT GCCGAACCTT ATCCGCGCCT TGATATTTGC 51CCTGGGTTTC ATCTTCCTGA ACGCCTGTTC GGaacaaacC GCGCAaaccg 101 TTACCCTGCAAGGCGAAACG ATGGGTACGA CCtATACCGT CAAATACCTT 151 TCAAATAATC GGGACAAACTCCCCTCCCCT GCCAAAATAC AAAAGCGCAT 201 TGATGATGCG CTTAAAGAAG TCAACCGGCAGATGtccaCC TACCAGACCG 251 ATTCCGAAAT CAGCCGGTTt atacagacan atgctggagagctcttcgcg 301 tntcatgcag nttctataac tgattccgcc gaagactgtc tgcctaatac351 gcctatctca tcggcgctct gaThis corresponds to the amino acid sequence <SEQ ID 394; ORF 111.ng>:

g111.pep 1 MPSETRLPNL IRALIFALGF IFLNACSEQT AQTVTLQGET MGTTYTVKYL 51SNNRDKLPSP AKIQKRIDDA LKEVNRQMST YQTDSEISRF IQTAGELFAH 101 ASITDSAEDCLPNTPISSAL *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 395>:

m111.seq 1 ATGCCGTCTG AAACACGCCT GCCGAACTTT ATCCGCGTCT TGATATTTGC 51CCTGGGTTTC ATCTTCCTGA ACGCCTGTTC GGAACAAACC GCGCAAACCG 101 TTACCCTGCAAGGCGAAACG ATGGGCACGA CCTATAyCGT CAAATACCTT 151 TCAAATAATC GGGACAAACTCCCCTCACCT GCCGAAATAC AwAAACGCAT 201 CGATGACGCG CTTAAAGAAk TCAACCGGyAGATGTCCACC TATCAGCCCG 251 ACTCCGAAAT CAGCCGGTTC AACCAACACA CAGCCGGCAAGCCCCTCCGC 301 ATTTCAAGCG ACTTCGCACA CGTTACTGCC GAAGCCGTCC GCCTGAACCG351 CCTGACACAC GGCGCGCTGG ACGTAACCGT CGGCCCCTTG GTCAACCTTT 401GGGGATTCGG CCCCGACAAA TCCGTTACCC GTGAACCGTC GCCGGAACAA 451 ATCAAACAGGCGGCATCTTA TACGGGCATA GACAAAATCA TTTTGAAACA 501 AGGCAAAGAT TACGCTTCCTTGAGCAAAAC CCACCCCAAG GCCTATTTGG 551 ATTTATCTTC GATTGCCAAA GGCTTCGGCGTTGATAAAGT TGCGGGCGAA 601 CTGGAAAAAT ACGGCATTCA AAATTATCTG GTCGAAATCGGCGGCGAGTT 651 GCACGGCAAA GGCAAAAACG CGCGCGGCGA ACCGTGGCGC ATCGGTATCG701 AGCAGCCCAA TATCGTCCAA GGCGGCAATA CGCAGATTAT CGTCCCGCTG 751AACAACCGTT CGCTTGCCAC TTCCGGCGAT TACCGTATTT TCCACGTCGA 801 TAAAAACGGCAAACGCCTCT CCCATATCAT CAACCCGAAC AACAAACGAC 851 CCATCAGCCA CAACCTCGCCTCCATCAGCG TGGTCGCAGA CAGTGCGATG 901 ACGGCGGACG GCTTGTCCAC AGGATTATTCGTATTGGGCG AAACCGAAGC 951 CTTAAAGCTG GCAGAGCGCG AAAAACTCGC TGTTTTCCTGATTGTCAGGG 1001 ATAAAGGCGG cTACCGCACC GCCATGTCTT CCGAATTTGA AAAACTGcTC1051 CGCTAAThis corresponds to the amino acid sequence <SEQ ID 396; ORF 111>:

m111.pep 1 MPSETRLPNF IRVLIFALGF IFLNACSEQT AQTVTLQGET MGTTYXVKYL 51SNNRDKLPSP AEIXKRIDDA LKEXNRXMST YQPDSEISRF NQHTAGKPLR 101 ISSDFAHVTAEAVRLNRLTH GALDVTVGPL VNLWGFGPDK SVTREPSPEQ 151 IKQAASYTGI DKIILKQGKDYASLSKTHPK AYLDLSSIAK GFGVDKVAGE 201 LEKYGIQNYL VEIGGELHGK GKNARGEPWRIGIEQPNIVQ GGNTQIIVPL 251 NNRSLATSGD YRIFHVDKNG KRLSHIINPN NKRPISHNLASISVVADSAM 301 TADGLSTGLF VLGETEALKL AEREKLAVFL IVRDKGGYRT AMSSEFEKLL351 R*ORF 111 shows 88.7% identity over a 97 aa overlap with a predicted ORF(ORF 111.ng) from N. gonorrhoeae:

m111.pep/g111.pep        10        20        30        40        50        60 m111.pepMPSETRLPNFIRVLIFALGFIFLNACSEQTAQTVTLQGETMGTTYXVKYLSNNRDKLPSP|||||||||:||:||||||||||||||||||||||||||||||||:|||||||||||||| g111MPSETRLPNLIRALIFALGFIFLNACSEQTAQTVTLQGETMGTTYTVKYLSNNRDKLPSP        10        20        30        40        50        60        70        80        90       100       110       120 m111.pepAEIXKRIDDALKEXNRXMSTYQPDSEISRFNQHTAGKPLRISSDFAHVTAEAVRLNRLTH|:| ||||||||| || ||||| ||||||| | :||: g111AKIQKRIDDALKEVNRQMSTYQTDSEISRFIQTXAGELFAXHAXSITDSAEDCLPNTPIS        70        80        90       100       110       120       130       140       150       160       170       180 m111.pepGALDVTVGPLVNLWGFGPDKSVTREPSPEQIKQAASYTGIDKIILKQGKDYASLSKTHPK g111 SALXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 397>:

a111.seq 1 ATGCCGTCTG AAACACGCCT GCCGAACTTT ATCCGCACCT TGATATTTGC 51CCTGAGTTTT ATCTTCCTGA ACGCCTGTTC GGAACAAACC GCGCAAACCG 101 TTACCCTGCAAGGTGAAACG ATGGGCACGA CCTATACCGT CAAATACCTT 151 TCAAATAATC GGGACAAACTCCCCTCACCT GCCGAAATAC AAAAGCGCAT 201 CGATGACGCG CTTAAAGAAG TCAACCGGCAGATGTCCACC TATCAGCCCG 251 ACTCCGAAAT CAGCCGGTTC AACCAACACA CAGCCGGCAAGCCCCTCCGC 301 ATTTCAAGCG ACTTCGCACA CGTTACTGCC GAAGCCGTCC ACCTGAACCG351 CCTGACACAC GGCGCGCTGG ACGTAACCGT CGGCCCCTTG GTCAACCTTT 401GGGGATTCGG CCCCGACAAA TCCGTTACCC GTGAACCGTC GCCGGAACAA 451 ATCAAACAAGCAGCATCTTA TACGGGCATA GACAAAATCA TTTTGAAACA 501 AGGCAAAGAT TACGCTTCCTTGAGCAAAAC CCACCCCAAG GCCTATTTGG 551 ATTTATCTTC GATTGCCAAA GGCTTCGGCGTTGATAAAGT TGCGGGCGAA 601 CTGGAAAAAT ACGGCATTCA AAATTATCTG GTCGAAATCGGCGGCGAGTT 651 GCACGGCAAA GGCAAAAACG CGCGCGGCGA ACCTTGGCGC ATCGGCATCG701 AACAGCCCAA CATCGTCCAA GGCGGCAATA CGCAGATTAT CGTCCCGCTG 751AACAACCGTT CGCTTGCCAC TTCCGGCGAT TACCGTATTT TCCACGTCGA 801 TAAAAGCGGCAAACGCCTCT CCCATATCAT TAATCCGAAC AACAAACGAC 851 CCATCAGCCA CAACCTCGCCTCCATCAGCG TGGTCGCAGA CAGTGCGATG 901 ACGGCGGACG GCTTGTCCAC AGGATTATTCGTATTGGGCG AAACCGAAGC 951 CTTAAAGCTG GCAGAGCGCG AAAAACTCGC TGTTTTCCTGATTGTCAGGG 1001 ATAAAGGCGG CTACCGCACC GCCATGTCTT CCGAATTTGA AAAACTGCTC1051 CGCTAAThis corresponds to the amino acid sequence <SEQ ID 398; ORF 111.a>:

a111.pep 1 MPSETRLPNF IRTLIFALSF IFLNACSEQT AQTVTLQGET MGTTYTVKYL 51SNNRDKLPSP AEIQKRIDDA LKEVNRQMST YQPDSEISRF NQHTAGKPLR 101 ISSDFAHVTAEAVHLNRLTH GALDVTVGPL VNLWGFGPDK SVTREPSPEQ 151 IKQAASYTGI DKIILKQGKDYASLSKTHPK AYLDLSSIAK GFGVDKVAGE 201 LEKYGIQNYL VEIGGELHGK GKNARGEPWRIGIEQPNIVQ GGNTQIIVPL 251 NNRSLATSGD YRIFHVDKSG KRLSHIINPN NKRPISHNLASISVVADSAM 301 TADGLSTGLF VLGETEALKL AEREKLAVFL IVRDKGGYRT AMSSEFEKLL351 R* m111/a111 97.7% identity in 351 aa overlap        10        20        30        40        50        60 m111.pepMPSETRLPNFIRVLIFALGFIFLNACSEQTAQTVTLQGETMGTTYXVKYLSNNRDKLPSP||||||||||||:|||||:||||||||||||||||||||||||||:|||||||||||||| a111MPSETRLPNFIRTLIFALSFIFLNACSEQTAQTVTLQGETMGTTYTVKYLSNNRDKLPSP        10        20        30        40        50        60        70        80        90       100       110       120 m111.pepAEIXKRIDDALKEXNRXMSTYQPDSEISRFNQHTAGKPLRISSDFAHVTAEAVRLNRLTH||| ||||||||| || ||||||||||||||||||||||||||||||||||||:|||||| a111AEIQKRIDDALKEVNRQMSTYQPDSEISRFNQHTAGKPLRISSDFAHVTAEAVHLNRLTH        70        80        90       100       110       120       130       140       150       160       170       180 m111.pepGALDVTVGPLVNLWGFGPDKSVTREPSPEQIKQAASYTGIDKIILKQGKDYASLSKTHPK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a111GALDVTVGPLVNLWGFGPDKSVIREPSPEQIKQAASYTGIDKIILKQGKDYASLSKTHPK       130       140       150       160       170       180       190       200       210       220       230       240 m111.pepAYLDLSSIAKGFGVDKVAGELEKYGIQNYLVEIGGELHGKGKNARGEPWRIGIEQPNIVQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a111AYLDLSSIAKGFGVDKVAGELEKYGIQNYLVEIGGELHGKGKNARGEPWRIGIEQPNIVQ       190       200       210       220       230       240       250       260       270       280       290       300 m111.pepGGNTQIIVPLNNRSLATSGDYRIFHVDKNGKRLSHIINPNNKRPISHNLASISVVADSAM||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||| a111GGNTQIIVPLNNRSLATSGDYRIFHVDKSGKRLSHIINPNNKRPISHNLASISVVADSAM       250       260       270       280       290       300       310       320       330       340       350 m111.pepTADGLSTGLFVLGETEALKLAEREKLAVFLIVRDKGGYRTAMSSEFEKLLRX|||||||||||||||||||||||||||||||||||||||||||||||||||| a111TADGLSTGLFVLGETEALKLAEREKLAVFLIVRDKGGYRTAMSSEFEKLLRX       310       320       330       340       350The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 399>:

g111-1.seq 1 ATGCCGTCTG AAACACGCCT GCCGAACCTT ATCCGCGCCT TGATATTTGC 51CCTGGGTTTC ATCTTCCTGA ACGCCTGTTC GGAACAAACC GCGCAAacCG 101 TTACCCTGCAAGGCGAAACG ATGGGTACGA CCTATACCGT CAAATACCTT 151 TCAAATAATC GGGACAAACTCCCCTCCCCT GCCAAAATAC AAAAGCGCAT 201 TGATGATGCG CTTAAAGAAG TCAACCGGCAGATGTCCACC TACCAGACCG 251 ATTCCGAAAT CAGCCGGTTC AACCAACACA CAGCCGGCAAGCCCCTCCGC 301 ATTTCAAGCG ATTTCGCACA CGTTACCGCC GAAGCCGTCC GCCTGAACCG351 CCTGACTCAC GGCGCACTGG ACGTAACCGT CGGCCCTTTG GTCAACCTTT 401GGGGGTTCGG CCCCGACAAA TCCGTTACCC GTGAACCGTC GCCGGAACAA 451 ATCAAACAGGCGGCATCTTA TACGGGCATA GACAAAATCA TTTTGCAACA 501 AGGCAAAGAT TACGCTTCCTTGAGCAAAAC CCACCCCAAA GCCTATTTGG 551 ATTTATCTTC GATTGCCAAA GGCTTCGGCGTTGATAAAGT TGCGGGCGAA 601 CTGGAAAAAT ACGGCATTCA AAATTATCTG GTCGAAATCGGCggcGAGTT 651 GCACGGCAAA GGCAAAAATG CGCACGGCGA ACCGTGGCGC ATCGGTATAG701 AGCAACCCAA TATcatccaa ggcggcaata cgcAGattat cgtcccgctg 751aaCaaccgtt cgcttgccac ttccggcgAT taccgtaTTT tccacgtcgA 801 TAAAAACGGCAaacgccttt cccacATCAT CAATCCCAAC AACAAACGAC 851 CCATCAGcCA CAAcctcgcctcCATCAgCg TGGTCTCAGA CAGTGCAATG 901 ACGGCGGACG GTTTATCCAC AGGATTATTTGTTTTAGGCG AAACCGAAGC 951 CTTAAGGCTG GCAGAACAAG AAAAACTCGC TGTTTTCCTAATTGTCCGGG 1001 ATAAGGACGG CTACCGCACC GCCATGTCTT CCGAATTTGC CAAGCTGCTC1051 CGCTAAThis corresponds to the amino acid sequence <SEQ ID 400; ORF 111-1.ng>:

g111-1.pep 1 MPSETRLPNL IRALIFALGF IFLNAC SEQT AQTVTLQGET MGTTYTVKYL 51SNNRDKLPSP AKIQKRIDDA LKEVNRQMST YQTDSEISRF NQHTAGKPLR 101 ISSDFAHVTAEAVRLNRLTH GALDVTVGPL VNLWGFGPDK SVTREPSPEQ 151 IKQAASYTGI DKIILQQGKDYASLSKTHPK AYLDLSSIAK GFGVDKVAGE 201 LEKYGIQNYL VEIGGELHGK GKNAHGEPWRIGIEQPNIIQ GGNTQIIVPL 251 NNRSLATSGD YRIFHVDKNG KRLSHIINPN NKRPISHNLASISVVSDSAM 301 TADGLSTGLF VLGETEALRL AEQEKLAVFL IVRDKDGYRT AMSSEFAKLL351 R*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 401>:

m111-1.seq 1 ATGCCGTCTG AAACACGCCT GCCGAACTTT ATCCGCGTCT TGATATTTGC 51CCTGGGTTTC ATCTTCCTGA ACGCCTGTTC GGAACAAACC GCGCAAACCG 101 TTACCCTGCAAGGCGAAACG ATGGGCACGA CCTATACCGT CAAATACCTT 151 TCAAATAATC GGGACAAACTCCCCTCACCT GCCGAAATAC AAAAACGCAT 201 CGATGACGCG CTTAAAGAAG TCAACCGGCAGATGTCCACC TATCAGCCCG 251 ACTCCGAAAT CAGCCGGTTC AACCAACACA CAGCCGGCAAGCCCCTCCGC 301 ATTTCAAGCG ACTTCGCACA CGTTACTGCC GAAGCCGTCC GCCTGAACCG351 CCTGACACAC GGCGCGCTGG ACGTAACCGT CGGCCCCTTG GTCAACCTTT 401GGGGATTCGG CCCCGACAAA TCCGTTACCC GTGAACCGTC GCCGGAACAA 451 ATCAAACAGGCGGCATCTTA TACGGGCATA GACAAAATCA TTTTGAAACA 501 AGGCAAAGAT TACGCTTCCTTGAGCAAAAC CCACCCCAAG GCCTATTTGG 551 ATTTATCTTC GATTGCCAAA GGCTTCGGCGTTGATAAAGT TGCGGGCGAA 601 CTGGAAAAAT ACGGCATTCA AAATTATCTG GTCGAAATCGGCGGCGAGTT 651 GCACGGCAAA GGCAAAAACG CGCGCGGCGA ACCGTGGCGC ATCGGTATCG701 AGCAGCCCAA TATCGTCCAA GGCGGCAATA CGCAGATTAT CGTCCCGCTG 751AACAACCGTT CGCTTGCCAC TTCCGGCGAT TACCGTATTT TCCACGTCGA 801 TAAAAACGGCAAACGCCTCT CCCATATCAT CAACCCGAAC AACAAACGAC 851 CCATCAGCCA CAACCTCGCCTCCATCAGCG TGGTCGCAGA CAGTGCGATG 901 ACGGCGGACG GCTTGTCCAC AGGATTATTCGTATTGGGCG AAACCGAAGC 951 CTTAAAGCTG GCAGAGCGCG AAAAACTCGC TGTTTTCCTGATTGTCAGGG 1001 ATAAAGGCGG CTACCGCACC GCCATGTCTT CCGAATTTGA AAAACTGCTC1051 CGCTAAThis corresponds to the amino acid sequence <SEQ ID 402; ORF 111-1>:

m111-1.pep 1 MPSETRLPNF IRVLIFALGF IFLNAC SEQT AQTVTLQGET MGTTYTVKYL 51SNNRDKLPSP AEIQKRIDDA LKEVNRQMST YQPDSEISRF NQHTAGKPLR 101 ISSDFAHVTAEAVRLNRLTH GALDVTVGPL VNLWGFGPDK SVTREPSPEQ 151 IKQAASYTGI DKIILKQGKDYASLSKTHPK AYLDLSSIAK GFGVDKVAGE 201 LEKYGIQNYL VEIGGELHGK GKNARGEPWRIGIEQPNIVQ GGNTQIIVPL 251 NNRSLATSGD YRIFHVDKNG KRLSHIINPN NKRPISHNLASISVVADSAM 301 TADGLSTGLF VLGETEALKL AEREKLAVFL IVRDKGGYRT AMSSEFEKLL351 R* m111-1/g111-1 96.6% identity in 351 aa overlap        10        20        30        40        50        60 m111-1.pepMPSETRLPNFIRVLIFALGFIFLNACSEQTAQTVTLQGETMGTTYTVKYLSNNRDKLPSP|||||||||:||:||||||||||||||||||||||||||||||||||||||||||||||| g111-1MPSETRLPNLIRALIFALGFIFLNACSEQTAQTVTLQGETMGTTYLVKYLSNNRDKLPSP        10        20        30        40        50        60        70        80        90       100       110       120 m111-1.pepAEIQKRIDDALKEVNRQMSTYQPDSEISRFNQHTAGKPLRISSDFAHVTAEAVRLNRLTH|:|||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| g111-1AKIQKRIDDALKEVNRQMSTYQTDSEISRFNQHTAGKPLRISSDFAHVTAEAVRLNRLTH        70        80        90       100       110       120       130       140       150       160       170       180 m111-1.pepGALDVTVGPLVNLWGFGPDKSVTREPSPEQIKQAASYTGIDKIILKQGKDYASLSKTHPK|||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||| g111-1GALDVTVGPLVNLWGFGPDKSVTREPSPEQIKQAASYTGIDKIILQQGKDYASLSKTHPK       130       140       150       160       170       180       190       200       210       220       230       240 m111-1.pepAYLDLSSIAKGFGVDKVAGELEKYGIQNYLVEIGGELHGKGKNARGEPWRIGIEQPNIVQ||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||:| g111-1AYLDLSSIAKGFGVDKVAGELEKYGIQNYLVEIGGELHGKGKNAHGEPWRIGIEQPNIIQ       190       200       210       220       230       240       250       260       270       280       290       300 m111-1.pepGGNTQIIVPLNNRSLATSGDYRIFHVDKNGKRLSHIINPNNKRPISHNLASISVVADSAM|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||| g111-1GGNTQIIVPLNNRSLATSGDYRIFHVDKNGKRLSHIINPNNKRPISHNLASISVVSDSAM       250       260       270       280       290       300       310       320       330       340       350 m111-1.pepTADGLSTGLFVLGETEALKLAEREKLAVFLIVRDKGGYRTAMSSEFEKLLRX||||||||||||||||||:|||:|||||||||||| |||||||||| ||||| g111-1TADGLSTGLFVLGETEALRLAEQEKLAVFLIVRDKDGYRTAMSSEFAKLLRX       310       320       330       340       350 g111-1/p44550sp|P44550|YOJL_HAEIN HYPOTHETICAL LIPOPROTEIN HI0172PRECURSOR >gi|1074292|pir||C64144 hypothetical protein HI0172 -Haemophilus influenzae (strain Rd KW20) >gi|1573128 (U32702)lipoprotein, putative [Haemophilus influenzae Rd] Length = 346 Score= 349 bits (885), Expect = 2e−95 Identities = 177/328 (53%), Positives= 240/328 (72%), Gaps = 4/328 (1%) Query: 23LNACSEQTAQTVTLQGETMGTTYXVKYLSNNRDKLPSPAEIXKRIDDALKEXNRXMSTYQ 82 L AC ++T+ ++L G+TMGTTY VKYL +      S  +  + I+  LK+ N  MSTY+ Sbjct: 17LAACQKET-KVISLSGKTMGTTYHVKYLDDGSITATS-EKTHEEIEAILKDVNAKMSTYK 74 Query:83 PDSEISRFNQHT-AGKPLRISSDFAHVTAEAVRLNRLTHGALDVTVGPLVNLWGFGPDKS 141 DSE+SRFNQ+T    P+ IS+DFA V AEA+RLN++T GALDVTVGP+VNLWGFGP+K Sbjct: 75KDSELSRFNQNTQVNTPIEISADFAKVLAEAIRLNKVTEGALDVTVGPVVNLWGFGPEKR 134 Query:142 VTREPSPEQIKQAASYTGIDKIILKQGKDYASLSKTHPKAYLDLSSIAKGFGVDKVAGEL 201  ++P+PEQ+ +  ++ GIDKI L   K+ A+LSK  P+ Y+DLSSIAKGFGVD+VA +L Sbjct: 135PEKQPTPEQLAERQAWVGIDKITLDTNKEKATLSKALPQVYVDLSSIAKGFGVDQVAEKL 194 Query:202 EKYGIQNYLVEIGGELHGKGKNARGEPWRIGIEQPNIVQGGNTQIIVPLNNRSLATSGDY 261E+   QNY+VEIGGE+  KGKN  G+PW+I IE+P        + ++ LNN  +A+SGDY Sbjct: 195EQLNAQNYMVEIGGEIRAKGKNIEGKPWQIAIEKPTTTGERAVEAVIGLNNMGMASSGDY 254 Query:262 RIFHVDKNGKRLSHIINPNNKRPISHNLASISVVADSAMTADGLSTGLFVLGETEALKLA 321RI+  ++NGKR +H I+P    PI H+LASI+V+A ++MTADGLSTGLFVLGE +AL++A Sbjct: 255RIY-FEENGKRFAHEIDPKTGYPIQHHLASITVLAPTSMTADGLSTGLFVLGEDKALEVA 313 Query:322 EREKLAVFLIVRDKGGYRTAMSSEFEKL 349 E+  LAV+LI+R   G+ T  SS F+KL Sbjct:314 EKNNLAVYLIIRTDNGFVTKSSSAFKKL 341The following partial DNA sequence was identified in N. meningitidis<SEQ ID 403>:

a111-1.seq 1 ATGCCGTCTG AAACACGCCT GCCGAACTTT ATCCGCACCT TGATATTTGC 51CCTGAGTTTT ATCTTCCTGA ACGCCTGTTC GGAACAAACC GCGCAAACCG 101 TTACCCTGCAAGGTGAAACG ATGGGCACGA CCTATACCGT CAAATACCTT 151 TCAAATAATC GGGACAAACTCCCCTCACCT GCCGAAATAC AAAAGCGCAT 201 CGATGACGCG CTTAAAGAAG TCAACCGGCAGATGTCCACC TATCAGCCCG 251 ACTCCGAAAT CAGCCGGTTC AACCAACACA CAGCCGGCAAGCCCCTCCGC 301 ATTTCAAGCG ACTTCGCACA CGTTACTGCC GAAGCCGTCC ACCTGAACCG351 CCTGACACAC GGCGCGCTGG ACGTAACCGT CGGCCCCTTG GTCAACCTTT 401GGGGATTCGG CCCCGACAAA TCCGTTACCC GTGAACCGTC GCCGGAACAA 451 ATCAAACAAGCAGCATCTTA TACGGGCATA GACAAAATCA TTTTGAAACA 501 AGGCAAAGAT TACGCTTCCTTGAGCAAAAC CCACCCCAAG GCCTATTTGG 551 ATTTATCTTC GATTGCCAAA GGCTTCGGCGTTGATAAAGT TGCGGGCGAA 601 CTGGAAAAAT ACGGCATTCA AAATTATCTG GTCGAAATCGGCGGCGAGTT 651 GCACGGCAAA GGCAAAAACG CGCGCGGCGA ACCTTGGCGC ATCGGCATCG701 AACAGCCCAA CATCGTCCAA GGCGGCAATA CGCAGATTAT CGTCCCGCTG 751AACAACCGTT CGCTTGCCAC TTCCGGCGAT TACCGTATTT TCCACGTCGA 801 TAAAAGCGGCAAACGCCTCT CCCATATCAT TAATCCGAAC AACAAACGAC 851 CCATCAGCCA CAACCTCGCCTCCATCAGCG TGGTCGCAGA CAGTGCGATG 901 ACGGCGGACG GCTTGTCCAC AGGATTATTCGTATTGGGCG AAACCGAAGC 951 CTTAAAGCTG GCAGAGCGCG AAAAACTCGC TGTTTTCCTGATTGTCAGGG 1001 ATAAAGGCGG CTACCGCACC GCCATGTCTT CCGAATTTGA AAAACTGCTC1051 CGCTAAThis corresponds to the amino acid sequence <SEQ ID 404; ORF 111-1.a>:

a111-1.pep 1 MPSETRLPNF IRTLIFALSF IFLNAC SEQT AQTVTLQGET MGTTYTVKYL 51SNNRDKLPSP AEIQKRIDDA LKEVNRQMST YQPDSEISRF NQHTAGKPLR 101 ISSDFAHVTAEAVHLNRLTH GALDVTVGPL VNLWGFGPDK SVTREPSPEQ 151 IKQAASYTGI DKIILKQGKDYASLSKTHPK AYLDLSSIAK GFGVDKVAGE 201 LEKYGIQNYL VEIGGELHGK GKNARGEPWRIGIEQPNIVQ GGNTQIIVPL 251 NNRSLATSGD YRIFHVDKSG KRLSHIINPN NKRPISHNLASISVVADSAM 301 TADGLSTGLF VLGETEALKL AEREKLAVFL IVRDKGGYRT AMSSEFEKLL351 R* a111-1/m111-1 98.9% identity in 351 aa overlap        10        20        30        40        50        60 a111-1.pepMPSETRLPNFIRTLIFALSFIFLNACSEQTAQTVTLQGETMGTTYTVKYLSNNRDKLPSP||||||||||||:|||||:||||||||||||||||||||||||||||||||||||||||| m111-1MPSETRLPNFIRVLIFALGFIFLNACSEQTAQTVTLQGETMGTTYTVKYLSNNRDKLPSP        10        20        30        40        50        60        70        80        90       100       110       120 a111-1.pepAEIQKRIDDALKEVNRQMSTYQPDSEISRFNQHTAGKPLRISSDFAHVTAEAVHLNRLTH|||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||| m111-1AEIQKRIDDALKEVNRQMSTYQPDSEISRFNQHTAGKPLRISSDFAHVTAEAVRLNRLTH        70        80        90       100       110       120       130       140       150       160       170       180 a111-1.pepGALDVTVGPLVNLWGFGPDKSVTREPSPEQIKQAASYTGIDKIILKQGKDYASLSKTHPK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m111-1GALDVTVGPLVNLWGFGPDKSVTREPSPEQIKQAASYTGIDKIILKQGKDYASLSKTHPK       130       140       150       160       170       180       190       200       210       220       230       240 a111-1.pepAYLDLSSIAKGFGVDKVAGELEKYGIQNYLVEIGGELHGKGKNARGEPWRIGIEQPNIVQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m111-1AYLDLSSIAKGFGVDKVAGELEKYGIQNYLVEIGGELHGKGKNARGEPWRIGIEQPNIVQ       190       200       210       220       230       240       250       260       270       280       290       300 a111-1.pepGGNTQIIVPLNNRSLATSGDYRIFHVDKSGKRLSHIINPNNKRPISHNLASISVVADSAM||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||| m111-1GGNTQIIVPLNNRSLATSGDYRIFHVDKNGKRLSHIINPNNKRPISHNLASISVVADSAM       250       260       270       280       290       300       310       320       330       340       350 a111-1.pepTADGLSTGLFVLGETEALKLAEREKLAVFLIVRDKGGYRTAMSSEFEKLLRX|||||||||||||||||||||||||||||||||||||||||||||||||||| m111-1TADGLSTGLFVLGETEALKLAEREKLAVFLIVRDKGGYRTAMSSEFEKLLRX       310       320       330       340       350The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 405>:

g114.seq 1 ATGGCTTCCA TCACTTCGCC GCTGCACGGG GCGCAGCAGG AATGCAGCAA 51GACTTTTTTA TGTCCGCCGG GCGGGACGAG TATGGGGCGG TCAATGTCGG 101 TAACGGTAGGTTTGTTTTGT GTTTCCATTA ACTTAACAAT ATCTGTCGAA 151 TACGGTCAAA GCGGCTATTTTACCAGAGCC GCCGAATGTA AAACAGGGTG 201 TCAGGGCATC AGCCCGAGCT GCCTGAACGAACGGACGGTT TGCGAGGTAA 251 CGATAAAATG GTCGAGCAGC GAAACATCAA CCAGCGACATGGCCTGTGCC 301 AGCCGCCTTG TGAACATGAT GTCTTCCTGC GAAGGTTCAG GCGAGCCGCC351 CGGATGGTTG TGCGCGATAA TCAGGCTGTC GGCATATTCG TCCAATGCCA 401GTTTGACGAT TTCGCGGATG TAAThis corresponds to the amino acid sequence <SEQ ID 406; ORF 114.ng>:

g114.pep 1 MASITSPLHG AQQECSKTFL CPPGGTSMGR SMSVTVGLFC VSINLTISVE 51YGQSGYFTRA AECKTGCQGI SPSCLNERTV CEVTIKWSSS ETSTSDMACA 101 SRLVNMMSSCEGSGEPPGWL CAIIRLSAYS SNASLTISRM *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 407>:

m114.seq 1 ATGGCTTCCA TCACTTCGCC GCTGCACGGG GCGCACAGAG AATGCAGCAA 51GACTTTTTTA TGTCCACCGG GCGGGACGAG TATAGGGCGG TCAATGTCGG 101 TAACGGTAGGTTTGTTTTGT GTTTCCATTA ACTTAACAAT ATCTGTTGAA 151 TACGGTTGAA GCGGCTATTTTATCAGAGCC GCCGCATGTA AAACAGAGTG 201 TCAGGGCATC AACCCGAGCT GTCTGAACGAACAGACGCTT TGCGAkGTAA 251 CGATAAAATG GTCGAGCAGC GACACATCGA CCAGCGACATTGCCTGTGCC 301 AGCCGCCTTG TGAACATGAT GTCTTCCTGC GAArGTTCsG GCGAGCCGcC351 CGgATGGTTG TGCGCAATAA TCAGGCTGTC GGCATATTCG TCCAATGCCA 401GTTTGACGAT TTCGCGGATG TAAThis corresponds to the amino acid sequence <SEQ ID 408; ORF 114>:

m114.pep 1 MASITSPLHG AHRECSKTFL CPPGGTSIGR SMSVTVGLFC VSINLTISVE 51YGXSGYFIRA AACKTECQGI NPSCLNEQTL CXVTIKWSSS DTSTSDIACA 101 SRLVNMMSSCEXSGEPPGWL CAIIRLSAYS SNASLTISRM * m114/g114 90.0% identity over a 140aa overlap         10        20        30        40        50        60m114.pep MASITSPLHGAHRECSKTFLCPPGGTSIGRSMSVTVGLFCVSINLTISVEYGXSGYFIRA|||||||||||::||||||||||||||:||||||||||||||||||||||| |||| || g114MASITSPLHGAQQECSKTFLCPPGGTSMGRSMSVTVGLFCVSINLTISVEYGQSGYFTRA        10        20        30        40        50        60        70        80        90       100       110       120 m114.pepAACKTECQGINPSCLNEQTLCXVTIKWSSSDTSTSDIACASRLVNMMSSCEXSGEPPGWL| ||| ||||:||||||:|:| ||||||||:|||||:|||||||||||||| |||||||| g114AECKTGCQGISPSCLNERTVCEVTIKWSSSETSTSDMACASRLVNMMSSCEGSGEPPGWL        70        80        90       100       110       120       130       140 m114.pep CAIIRLSAYSSNASLTISRMX||||||||||||||||||||| g114 CAIIRLSAYSSNASLTISRMX        130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 409>:

a114.seq 1 ATGCCGGAGG CAAGCATCGC CTCCATCACT TCGCCGCTGC ACGGGGCGCA 51ACAGGAATGC AGCAAGACTT TTTTATGTCC GCCGGGCGGG ACGAGTATGG 101 GGCGGTCAATGTCGGTAACG GTAGGTTTGT TTTGTGTTTC CATTAACTTA 151 ACGATATCTG TCGAATACGGTTGAAGCGGC TATTTTATCA GAGCCGCCGC 201 ATGTAAAACA GGGTGTCAGG GCATCAGCCCGAGCTGCCTG AACGAACGGA 251 CGGTTTGCGC CGTTACGATA AAATGGTCGA GCAGCGACACATCGACCAGC 301 GACATTGCCT GTGCCAGCCG CCTTGTGAAC ATGATGTCTT CCTGCGAAGG351 TTCGGGCGAG CCGCCCGGAT GGTTGTGCGC GATAATCAGG CTGTCGGCAT 401ATTCGTCCAA TGCCAGTTTG ACAATTTCAC GGATGTAAThis corresponds to the amino acid sequence <SEQ ID 410; ORF 114.a>:

a114.pep 1 MPEASIASIT SPLHGAQQEC SKTFLCPPGG TSMGRSMSVT VGLFCVSINL 51TISVEYG*SG YFIRAAACKT GCQGISPSCL NERTVCAVTI KWSSSDTSTS 101 DIACASRLVNMMSSCEGSGE PPGWLCAIIR LSAYSSNASL TISRM* m114/a114 92.9% identity in 140aa overlap              10        20        30        40        50m114.pep      MASITSPLHGAHRECSKTFLCPPGGTSIGRSMSVTVGLFCVSINLTISVEYGXSG     :||||||||||::||||||||||||||:||||||||||||||||||||||||||| a114MPEASIASITSPLHGAQQECSKTFLCPPGGTSMGRSMSVTVGLFCVSINLTISVEYGXSG        10        20        30        40        50        60   60        70        80        90       100       110 m114.pepYFIRAAACKTECQGINPSCLNEQTLCXVTIKWSSSDTSTSDIACASRLVNMMSSCEXSGE|||||||||| ||||:||||||:|:| ||||||||||||||||||||||||||||| ||| a114YFIRAAACKTGCQGISPSCLNERTVCAVTIKWSSSDTSTSDIACASRLVNMMSSCEGSGE        70        80        90       100       110       120  120       130       140 m114.pep PPGWLCAIIRLSAYSSNASLTISRMX|||||||||||||||||||||||||| a114 PPGWLCAIIRLSAYSSNASLTISRMX       130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 411>:

g117.seq 1 atggtcgacg aactcgacCT GCTGCCCGAT GCCGTCGCCG CCACCCTGCT 51TGCCGACATC GGACGCTACG TCCCCGATTG GAACCTATTG GTTTCCGAGC 101 GCTGCAACAGCACCGTCGCC GAGCTGGTCA AAGGTGtgga CGAAGTGCAG 151 AAACTTACCC ACTTCGCCCGGGTGGACAGC CTCGCCACGC CGGAAGAACG 201 CGCACAGCAA GCGGAAACCA TGCGGAAAATGCTGCTGGCg atggttaccg 251 Acatccgcgt cgtaTTAATC AAACTGGCGA TGCGTacgcgcaccCTGcta 301 ttTTtaaGCA ACGCCCCCGA CAGCCCTGAA AAACgcgccG TCgccaaAga351 aacccTCGAC ATCTTCGCCC CGCTCGCCAA CCGCTTGGGC GTGTGGCAGC 401TCAAATGGCA GCTCGAAGAT TTGGGCTTCC GCCATCAAGA ACCCGAAAAA 451 TACCGCGAAATCGCCCTGCT TTTGGACGAA AAACGCACCG AACGCCTCGA 501 ATACATCGAA AACTTCCTCGATATCCTGCG TACGGAACTC AAAAAATACA 551 ATATCCACTT TGAAGTCGCC GGCCGTCCGAAACACATCTA CTCCATTTAC 601 AAAAAAATGG TGAAGAAAAA ACTCAGCTTC GACGgccTGTTCGACATCCG 651 CGCCGTGCGG ATTCTGGTCG ATACCGTCCC CGaGTGTTAC ACCACGCTGG701 gcaTCGTCCA CAGCCTCTGG CAGCCCATTC CCGGCGagtt CGAcgactAC 751ATCGCCAACC CCAAAGgcaA CGgttATAAA AGtTTGCACA CCGTCATCGT 801 cggcccGGAagacaaaggtg tggaaGtgCA AATCCGCACC TTCGAtatGC 851 accAATTCaa CgaatTcggTgtcgccgCCC ACTGGCGtta caaagaaggc 901 ggcaaaggcg attccGCCtA cgaacaaAAAATcgccTggt TGCgccaACT 951 CTTGGACTGG CGCGAAAATA TGGCGGAAAG CGGCAAGGAAGACCTCGCCG 1001 CCGCCTTCAA AACCGAGCTT TTCAACGACA CGATTTATGT TTTGACCCCG1051 CACGGCAAAG TCCTCTCTCT GCCAACGGGC GCAACCCCCA TCGACTTCGC 1101CTACGCCCTG CACAGCAGCA TcggCGACCG CTGCCGGGGC GCGAAAGTCG 1151 AaggGCAGATTGTGCCGCTG TCCACCCCGC TCGAAAACGG ACAGCGCGTC 1201 GAAATcatta cCGCcaaAGAAGGGCATCCT TCCGTCAACT GGCTTTACGA 1251 AGGctgGGtc aAATCCGGCA AGGCCATCGGcaaAATCCGC GCCTAcatCC 1301 GCCAGcaaAa cgCcgaCACC GTGCGCGAAG AAGGCCGTGTCCAACTCGAC 1351 AAGCAGCTTG CCAAACTCAC GCCCAAACCC AACCTGCAAG AGCTTgccga1401 aaATCTCGGC tacaaAAAGC cagaagacct ctacacCGCc gtcggacaag 1451gcgaaatttc caaccgcgcc atCcaaaaag cctgcggcac GCTgaacgaa 1501 ccgccccCCGTGCCCGTCAG CGCAACCACC ATCGTCAAAC AGTCCAAAAT 1551 CAAAAAAGGT GGCAAAACCGGCGTGCTCAT CGACGGCGAA GACGGCTTGA 1601 TGACCACGCT TGCCAAATGC TGCAAACCCGCGCCGCCCGA CGATATTGCC 1651 GGCTTCGTTA CCCGCGAGCG CGGCATTTCC GTCCACCGCAAAACCTGCCC 1701 CTCTTTCCGA CACCTTGCCG AACACGCGCC CGAAAAAGTA CTGGACGCAA1751 GTTGGGCGGC GTTGCAGGAA GGGCAAGTGT TCGCCGTCGA TATCGAAATC 1801CGCGCCCAAG ACCGCTCCGG GCTTTTGCGC GACGTATCCG ACGCGCTCGC 1851 CCGCCACAAACTCAACGTTA CCGCCGTGCA AACCCAGTCC CGCGACTTGG 1901 AAGCCAGCAT GAGGTTCACGCTCGAAGTCA AACAAGtCAA CGacCTCCCG 1951 CGCGTCCTCG CCGGCCTCGG CGATGTCAAAGGCGTATTGA GCGTTACCCG 2001 GCTTTAAThis corresponds to the amino acid sequence <SEQ ID 412; ORF 117.ng>:

g117.pep 1 MVDELDLLPD AVAATLLADI GRYVPDWNLL VSERCNSTVA ELVKGVDEVQ 51KLTHFARVDS LATPEERAQQ AETMRKMLLA MVTDIRVVLI KLAMRTRTLL 101 FLSNAPDSPEKRAVAKETLD IFAPLANRLG VWQLKWQLED LGFRHQEPEK 151 YREIALLLDE KRTERLEYIENFLDILRTEL KKYNIHFEVA GRPKHIYSIY 201 KKMVKKKLSF DGLFDIRAVR ILVDTVPECYTTLGIVHSLW QPIPGEFDDY 251 IANPKGNGYK SLHTVIVGPE DKGVEVQIRT FDMHQFNEFGVAAHWRYKEG 301 GKGDSAYEQK IAWLRQLLDW RENMAESGKE DLAAAFKTEL FNDTIYVLTP351 HGKVLSLPTG ATPIDFAYAL HSSIGDRCRG AKVEGQIVPL STPLENGQRV 401EIITAKEGHP SVNWLYEGWV KSGKAIGKIR AYIRQQNADT VREEGRVQLD 451 KQLAKLTPKPNLQELAENLG YKKPEDLYTA VGQGEISNRA IQKACGTLNE 501 PPPVPVSATT IVKQSKIKKGGKTGVLIDGE DGLMTTLAKC CKPAPPDDIA 551 GFVTRERGIS VHRKTCPSFR HLAEHAPEKVLDASWAALQE GQVFAVDIEI 601 RAQDRSGLLR DVSDALARHK LNVTAVQTQS RDLEASMRFTLEVKQVNDLP 651 RVLAGLGDVK GVLSVTRL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 413>:

m117.seq (partial) 1 ..GTGAAACTCA AGAAATACAA TGTCCATTTC GAAGTCGCCGGCCGCCCGAA 51   ACACATCTAC TCCATTTACA AAAAAATGGT GAAGAAAAAA CTCAGCTTCG101   ACGGCCTCTT TGACATCCGC GCCGTGCGAA TTCTGGTTGA TACCGTCCCC 151  GAGTGTTACA CCACGCTGGG TATCGTCCAC AGCCTCTGGC AGCCCATTCC 201  CGGCGAGTTC GACGACTACA TCGCCAATCC CAAAGGCAAC GGCTATAAAA 251  GTTTGCACAC CGTCATCGTC GGCCCGGAAG ACAAAGGCGT GGAAGTACAA 301  ATCCGCACCT TCGATATGCA CCAATTCAAC GAATTCGGTG TCGCCGCCCA 351  CTGgCGTTAC AAAGAGGGCG GCAAGGGCGA TTCCGCCTAC GAACAGAAAA 401  TCGCCTGGTT GCGCCAACTC TTGGACTGGC GCGAAAACAT GGCGGAAAGC 451  GGCAAGGAAG ACCTCGCCGC CGCCTTCAAA ACCGAGCTTT TCAACGACAC 501  GATTTATGTT TTGACCCCGC ACGGCAAAGT CCTCTCCCTG CCCACGGGCG 551  CGACCCCCAT CGACTTCGCC TACGCCCTGC ACAGCAGCAT CGGCGACCGT 601  TGCCGCGGTG CGAAAGTCGA AGGGCAGATT GTGCCGCTGT CCACCCCGCT 651  CGAAAACGGA CAGCGCGTCG AAATCATTAC CGCCAAAGAA GGGCATCCTT 701  CCGTCAACTG GCTTTACGAA GGCTGGGTCA AATCCAACAA GGCAATCGGC 751  AAAATCCGCG CCTACATCCG CCAGCAAAAC GCCGACACCG TGCGCGAAGA 801  AGGCCGCGTC CAACTCGACA AACAGCTTGC CAAACTCACG CCCAAACCCA 851  ACCTGCAAGA GCTTGCCGAA AATCTCGGCT ACAAAAAGCC AGAAGACCTC 901  TACACCGCCG TCGGACAAGG CGAAATTTCC AACCGCGCCA TCCAAAAAGC 951  CTGCGGCACg CTGAACGAAC CGCCGCCCGT ACCCGTCAGC GAAACCACCA 1001  TCGTCAAACA GTCCAAAATC AAAAAAGGCG GCAAAAACGG CGTGCTCATC 1051  GACGGCGAAG ACGGTCTGAT GACCACGCTT GCCAAATGCT GCAAACCCGC 1101  GCCGCCCGAC GATATTATCG GCTTCGTTAC CCGCGAGCGC GgCATTTCAG 1151  TGCACCGCAA AwyyTkCyCG TCTTTCCAAC ACCTCGCCGA ACACGCGCCC 1201  GAwAAAGTGC TGGACGCAAG CTGGGCGGCA TTGCAGGAAG GACAAGTATT 1251  CGCCGTCGAT ATCGAAATCC GCGCCCAAGA CCGCTCCGGG CTTTTGCGCG 1301  ACGTATCCGA CGCGCTCGCC CGCCACAAAC TCAACGTTAC CGCCGTGCAA 1351  ACCCAGTCCC GCGACTTGGA AGCCAGCATG AGGTTCACGC TCGAAGTCAA 1401  ACAAGTCAAC GACCTCCCGC GCGTCCTCGC CAGCCTCGGC GACGTCAAAG 1451  GCGTATTGAG CGTTACCCGG CTTTAAThis corresponds to the amino acid sequence <SEQ ID 414; ORF 117>:

m117.pep (partial) 1 ....VKLKKYNVHF EVAGRPKHIY SIYKKMVKKK LSFDGLFDIRAVRILVDTVP 51     ECYTTLGIVH SLWQPIPGEF DDYIANPKGN GYKSLHTVIV GPEDKGVEVQ101     IRTFDMHQFN EFGVAAHWRY KEGGKGDSAY EQKIAWLRQL LDWRENMAES 151    GKEDLAAAFK TELFNDTIYV LTPHGKVLSL PTGATPIDFA YALHSSIGDR 201    CRGAKVEGQI VPLSTPLENG QRVEIITAKE GHPSVNWLYE GWVKSNKAIG 251    KIRAYIRQQN ADTVREEGRV QLDKQLAKLT PKPNLQELAE NLGYKKPEDL 301    YTAVGQGEIS NRAIQKACGT LNEPPPVPVS ETTIVKQSKI KKGGKNGVLI 351    DGEDGLMTTL AKCCKPAPPD DIIGFVTRER GISVHRKXXX SFQHLAEHAP 401    XKVLDASWAA LQEGQVFAVD IEIRAQDRSG LLRDVSDALA RHKLNVTAVQ 451    TQSRDLEASM RFTLEVKQVN DLPRVLASLG DVKGVLSVTR L*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 117 shows 97.6% identity over a 490 aa overlap with a predicted ORF(ORF 117.ng) from N. gonorrhoeae:

m117/g117                                       10        20        30m117.pep                               VKLKKYNVHFEVAGRPKHIYSIYKKMVKKKL                               :|||||:||||||||||||||||||||||| g117 EKYREIALLLDEKRTERLEYIENFLDILRTELKKYNIHFEVAGRPKHIYSIYKKMVKKKL150       160       170       180       190       200        40        50        60        70        80        90 m117.pep SFDGLFDIRAVRILVDTVPECYTTLGIVHSLWQPIPGEFDDYIANPKGNGYKSLHTVIVG |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g117 SFDGLFDIRAVRILVDTVPECYTTLGIVHSLWQPIPGEFDDYIANPKGNGYKSLHTVIVG210       220       230       240       250       260       100       110       120       130       140       150 m117.pep PEDKGVEVQIRTFDMHQFNEFGVAAHWRYKEGGKGDSAYEQKIAWLRQLLDWRENMAESG |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g117 PEDKGVEVQIRTFDMHQFNEFGVAAHWRYKEGGKGDSAYEQKIAWLRQLLDWRENMAESG270       280       290       300       310       320       160       170       180       190       200       210 m117.pep KEDLAAAFKTELFNDTIYVLTPHGKVLSLPTGATPIDFAYALHSSIGDRCRGAKVEGQIV |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g117 KEDLAAAFKTELFNDTIYVLTPHGKVLSLPTGATPIDFAYALHSSIGDRCRGAKVEGQIV330       340       350       360       370       380       220       230       240       250       260       270 m117.pep PLSTPLENGQRVEIITAKEGHPSVNWLYEGWVKSNKAIGKIRAYIRQQNADTVREEGRVQ ||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||| g117 PLSTPLENGQRVEIITAKEGHPSVNWLYEGWVKSGKAIGKIRAYIRQQNADTVREEGRVQ390       400       410       420       430       440       280       290       300       310       320       330 m117.pep LDKQLAKLTPKPNLQELAENLGYKKPEDLYTAVGQGEISNRAIQKACGTLNEPPPVPVSE ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g117 LDKQLAKLTPKPNLQELAENLGYKKPEDLYTAVGQGEISNRAIQKACGTLNEPPPVPVSA450       460       470       480       490       500       340       350       360       370       380       390 m117.pep TTIVKQSKIKKGGKNGVLIDGEDGLMTTLAKCCKPAPPDDIIGFVTRERGISVHRKXXXS ||||||||||||||:|||||||||||||||||||||||||| ||||||||||||||: | g117 TTIVKQSKIKKGGKTGVLIDGEDGLMTTLAKCCKPAPPDDIAGFVTRERGISVHRKTCPS510       520       530       540       550       560       400       410       420       430       440       450 m117.pep FQHLAEHAPXKVLDASWAALQEGQVFAVDIEIRAQDRSGLLRDVSDALARHKLNVTAVQT |:||||||| |||||||||||||||||||||||||||||||||||||||||||||||||| g117 FRHLAEHAPEKVLDASWAALQEGQVFAVDIEIRAQDRSGLLRDVSDALARHKLNVTAVQT570       580       590       600       610       620       460       470       480       490 m117.pep QSRDLEASMRFTLEVKQVNDLPRVLASLGDVKGVLSVTRLX ||||||||||||||||||||||||||:|||||||||||||| g117 QSRDLEASMRFTLEVKQVNDLPRVLAGLGDVKGVLSVTRLX630       640       650       660The following partial DNA sequence was identified in N. meningitidis<SEQ ID 415>:

a117.seq 1 ATGGTTCATG AACTCGACCT GCTCCCCGAT GCCGTCGCCG CCACCCTGCT 51TGCCGACATC GGACGCTACG TCCCCGACTG GAACCTATTG GTTTCCGAAC 101 GCTGCAACAGTACCGTCGCC GAGCTGGTCA AAGGTGTGGA CGAAGTGCAG 151 AAACTCACCC ACTTCGCCCGGGTGGACAGC CTCGCCACGC CGGAAGAACG 201 CGCCCAGCAG GCAGAAACTA TGCGGAAAATGCTGCTGGCG ATGGTTACCG 251 ACATCCGCGT CGTGTTAATC AAACTGGCGA TGCGTACGCGCACCCTGCAA 301 TTTTTAAGCA ACGCCCCCGA CAGCCCCGAA AAACGCGCCG TCGCCAAAGA351 AACCCTCGAC ATCTTCGCCC CGCTCGCCAA CCGTTTGGGC GTGTGGCAGC 401TCAAATGGCA GCTCGAAGAT TTGGGCTTCC GCCATCAAGA ACCCGAAAAA 451 TACCGCGAAATCGCCCTGCT TTTGGACGAA AAACGCACCG AACGCCTCGA 501 ATACATCGAA AACTTCCTTAATATCCTGCG TACGGAACTC AAAAAATACA 551 ATATCCACTT TGAAGTCGCC GGCCGTCCGAAACACATCTA CTCCATTTAC 601 AAAAAAATGG TGAAGAAAAA ACTCAGCTTC GACGGGTTGTTCGACATCCG 651 CGCCGTGCGG ATTCTGGTTG ATACCGTCCC CGAGTGTTAC ACCACACTGG701 GCATTGTCCA CAGCCTCTGG CAGCCCATTC CCGGCGAGTT CGACGACTAC 751ATCGCCAACC CGAAAGGCAA CGGCTATAAA AGTTTGCACA CCGTCATCGT 801 CGGCCCGGAAGACAAAGGCG TGGAAGTGCA AATCCGCACC TTCGATATGC 851 ACCAATTCAA CGAATTCGGTGTCGCCGCGC ACTGGCGTTA CAAAGAGGGC 901 GGCAAAGGCG ATTCCGCCTA CGAACAAAAAATCGCCTGGT TACGCCAACT 951 TTTGGACTGG CGCGAAAACA TGGCGGAAAG CGGCAAGGAAGACCTCGCCG 1001 CCGCCTTCAA AACCGAGCTT TTCAACGACA CGATTTATGT TTTGACCCCG1051 CACGGCAAAG TCCTCTCCCT GCCCACAGGC GCGACCCCCA TCGACTTCGC 1101CTACGCCCTG CACAGCAGCA TCGGCGACCG TTGCCGCGGT GCGAAAGTCG 1151 AAGGGCAGATTGTGCCGCTG TCCACCCCGC TCGAAAACGG ACAGCGTGTC 1201 GAAATCATTA CCGCCAAAGAAGGGCATCCT TCCGTCAACT GGCTTTACGA 1251 AGGCTGGGTC AAATCCAACA AGGCAATCGGCAAAATCCGC GCCTACATCC 1301 GCCAGCAAAA CGCCGACACC GTGCGCGAAG AAGGCCGCGTCCAACTCGAC 1351 AAACAGCTTG CCAAACTCAC GCCCAAACCC AACCTGCAAG AGCTTGCCGA1401 AAATCTCGGC TACAAAAAGC CAGAAGACCT CTACACCGCC GTCGGACAAG 1451GCGAAATTTC CAACCGCGCC ATCCAAAAAG CCTGCGGCAC GCTGAACGAA 1501 CCGCCGCCCGTACCCGTCAG CGAAACCACC ATCGTCAAAC AGTCCAAAAT 1551 CAAAAAAGGC GGCAAAAACGGCGTGCTCAT CGACGGCGAA GACGGTCTGA 1601 TGACCACGCT TGCCAAATGC TGCAAACCCGCGCCGCCCGA CGACATTGTC 1651 GGCTTCGTTA CCCGCGATCG CGGCATTTCG GTACACCGCAAAACCTGCCC 1701 CTCTTTCCGA CACCTCGCCG AACACGCGCC CGAAAAAGTA CTGGACGCAA1751 GTTGGGCGGC GTTGCAGGAA GGACAAGTGT TCGCCGTCGA TATCGAAATC 1801CGCGCCCAAG ACCGCTCCGG GCTTTTGCGC GACGTATCCG ACGCGCTCGC 1851 CCGCCACAAACTCAACGTTA CCGCCGTGCA AACCCAGTCC CGCGACTTGG 1901 AAGCCAGCAT GAGGTTCACGCTCGAAGTCA AACAAGTTAC CGACCTCCCA 1951 CGCGTCCTCG CCAGCCTCGG CGACGTCAAAGGCGTATTGA GCGTTACCCG 2001 GCTTTAAThis corresponds to the amino acid sequence <SEQ ID 416; ORF 117.a>:

a117.pep 1 MVHELDLLPD AVAATLLADI GRYVPDWNLL VSERCNSTVA ELVKGVDEVQ 51KLTHFARVDS LATPEERAQQ AETMRKMLLA MVTDIRVVLI KLAMRTRTLQ 101 FLSNAPDSPEKRAVAKETLD IFAPLANRLG VWQLKWQLED LGFRHQEPEK 151 YREIALLLDE KRTERLEYIENFLNILRTEL KKYNIHFEVA GRPKHIYSIY 201 KKMVKKKLSF DGLFDIRAVR ILVDTVPECYTTLGIVHSLW QPIPGEFDDY 251 IANPKGNGYK SLHTVIVGPE DKGVEVQIRT FDMHQFNEFGVAAHWRYKEG 301 GKGDSAYEQK IAWLRQLLDW RENMAESGKE DLAAAFKTEL FNDTIYVLTP351 HGKVLSLPTG ATPIDFAYAL HSSIGDRCRG AKVEGQIVPL STPLENGQRV 401EIITAKEGHP SVNWLYEGWV KSNKAIGKIR AYIRQQNADT VREEGRVQLD 451 KQLAKLTPKPNLQELAENLG YKKPEDLYTA VGQGEISNRA IQKACGTLNE 501 PPPVPVSETT IVKQSKIKKGGKNGVLIDGE DGLMTTLAKC CKPAPPDDIV 551 GFVTRDRGIS VHRKTCPSFR HLAEHAPEKVLDASWAALQE GQVFAVDIEI 601 RAQDRSGLLR DVSDALARHK LNVTAVQTQS RDLEASMRFTLEVKQVTDLP 651 RVLASLGDVK GVLSVTRL* m117/a117 98.0% identity in 490 aaoverlap                                       10        20        30m117.pep                               VKLKKYNVHFEVAGRPKHIYSIYKKMVKKKL                               :|||||:||||||||||||||||||||||| a117 EKYREIALLLDEKRTERLEYIENFLNILRTELKKYNIHFEVAGRPKHIYSIYKKMVKKKL150       160       170       180       190       200        40        50        60        70        80        90 m117.pep SFDGLFDIRAVRILVDTVPECYTTLGIVHSLWQPIPGEFDDYIANPKGNGYKSLHTVIVG |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a117 SFDGLFDIRAVRILVDTVPECYTTLGIVHSLWQPIPGEFDDYIANPKGNGYKSLHTVIVG210       220       230       240       250       260       100       110       120       130       140       150 m117.pep PEDKGVEVQIRTFDMHQFNEFGVAAHWRYKEGGKGDSAYEQKIAWLRQLLDWRENMAESG |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a117 PEDKGVEVQIRTFDMHQFNEFGVAAHWRYKEGGKGDSAYEQKIAWLRQLLDWRENMAESG270       280       290       300       310       320       160       170       180       190       200       210 m117.pep KEDLAAAFKTELFNDTIYVLTPHGKVLSLPTGATPIDFAYALHSSIGDRCRGAKVEGQIV |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a117 KEDLAAAFKTELFNDTIYVLTPHGKVLSLPTGATPIDFAYALHSSIGDRCRGAKVEGQIV330       340       350       360       370       380       220       230       240       250       260       270 m117.pep PLSTPLENGQRVEIITAKEGHPSVNWLYEGWVKSNKAIGKIRAYIRQQNADTVREEGRVQ |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a117 PLSTPLENGQRVEIITAKEGHPSVNWLYEGWVKSNKAIGKIRAYIRQQNADTVREEGRVQ390       400       410       420       430       440       280       290       300       310       320       330 m117.pep LDKQLAKLTPKPNLQELAENLGYKKPEDLYTAVGQGEISNRAIQKACGTLNEPPPVPVSE |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a117 LDKQLAKLTPKPNLQELAENLGYKKPEDLYTAVGQGEISNRAIQKACGTLNEPPPVPVSE450       460       470       480       490       500       340       350       360       370       380       390 m117.pep TTIVKQSKIKKGGKNGVLIDGEDGLMTTLAKCCKPAPPDDIIGFVTRERGISVHRKXXXS |||||||||||||||||||||||||||||||||||||||||:|||||:||||||||:  | a117 TTIVKQSKIKKGGKNGVLIDGEDGLMTTLAKCCKPAPPDDIVGFVTRDRGISVHRKTCPS510       520       530       540       550       560       400       410       420       430       440       450 m117.pep FQHLAEHAPXKVLDASWAALQEGQVFAVDIEIRAQDRSGLLRDVSDALARHKLNVTAVQT |:||||||| |||||||||||||||||||||||||||||||||||||||||||||||||| a117 FRHLAEHAPEKVLDASWAALQEGQVFAVDIEIRAQDRSGLLRDVSDALARHKLNVTAVQT570       580       590       600       610       620       460       470       480       490 m117.pep QSRDLEASMRFTLEVKQVNDLPRVLASLGDVKGVLSVTRLX ||||||||||||||||||:|||||||||||||||||||||| a117 QSRDLEASMRFTLEVKQVTDLPRVLASLGDVKGVLSVTRLX630       640       650       660The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 417>:

g117-1.seq 1 ATGACCGCCA TCAGCCCGAT TCAAGACACG CAAAGCGCGA CCCTGCAAGA 51ATTGCGCGAA TGGTTCGACA GCTACTGCGC CGCTCTGCCG GACAACGATA 101 AAAACCTCATCGGTACCGCA TGGTCGCTGG CGCAGGAACA TTATCCTGCC 151 GATGCCGCCA CGCCGTATGGCGAGCCGCTG CCCGACCACT TCCTCGGCGC 201 GGCGCAAATG GTCGACGAAC TCGACCTGCTGCCCGATGCC GTCGCCGCCA 251 CCCTGCTTGC CGACATCGGA CGCTACGTCC CCGATTGGAACCTATTGGTT 301 TCCGAGCGCT GCAACAGCAC CGTCGCCGAG CTGGTCAAAG GTGTGGACGA351 AGTGCAGAAA CTTACCCACT TCGCCCGGGT GGACAGCCTC GCCACGCCGG 401AAGAACGCGC ACAGCAAGCG GAAACCATGC GGAAAATGCT GCTGGCGATG 451 GTTACCGACATCCGCGTCGT ATTAATCAAA CTGGCGATGC GTACGCGCAC 501 CCTGCAATTT TTAAGCAACGCCCCCGACAG CCCTGAAAAA CGCGCCGTCG 551 CCAAAGAAAC CCTCGACATC TTCGCCCCGCTCGCCAACCG CTTGGGCGTG 601 TGGCAGCTCA AATGGCAGCT CGAAGATTTG GGCTTCCGCCATCAAGAACC 651 CGAAAAATAC CGCGAAATCG CCCTGCTTTT GGACGAAAAA CGCACCGAAC701 GCCTCGAATA CATCGAAAAC TTCCTCGATA TCCTGCGTAC GGAACTCAAA 751AAATACAATA TCCACTTTGA AGTCGCCGGC CGTCCGAAAC ACATCTACTC 801 CATTTACAAAAAAATGGTGA AGAAAAAACT CAGCTTCGAC GGCCTGTTCG 851 ACATCCGCGC CGTGCGGATTCTGGTCGATA CCGTCCCCGA GTGTTACACC 901 ACGCTGGGCA TCGTCCACAG CCTCTGGCAGCCCATTCCCG GCGagttCGA 951 cgactACATC GCCAACCCCA AAGgcaACGg ttATAAAAGtTTGCACACCG 1001 TCATCGTcgg cccGGAagaa aaaggtgtgg aagtgcAAAT CCGCACCTTC1051 GATATGCacc AATTCaaCga ATTCGGTGTC GCCGCCCACT GGCGTTACAA 1101AGAAGGCGGC AAAGGCGATT CCGCCTACGA ACAAAAAATC GCCTGGTTGC 1151 GCCAACTCTTGGACTGGCGC GAAAATATGG CGGAAAGCGG CAAGGAAGAC 1201 CTCGCCGCCG CCTTCAAAACCGAGCTTTTC AACGACACGA TTTATGTTTT 1251 GACCCCGCAC GGCAAAGTCC TCTCTCTGCCAACGGGCGCA ACCCCCATCG 1301 ACTTCGCCTA CGCCCTGCAC AGCAGCATCG GCGACCGCTGCCGGGGCGCG 1351 AAAGTCGAAG GGCAGATTGT GCCGCTGTCC ACCCCGCTCG AAAACGGACA1401 GCGCGTCGAA ATCATTACCG CCAAAGAAGG GCATCCTTCC GTCAACTGGC 1451TTTACGAAGG CTGGGTCAAA TCCGGCAAGG CCATCGGCAA AATCCGCGCC 1501 TACATCCGCCAGCAAAACGC CGACACCGTG CGCGAAGAAG GCCGTGTCCA 1551 ACTCGACAAG CAGCTTGCCAAACTCACGCC CAAACCCAAC CTGCAAGAGC 1601 TTGCCGAAAA TCTCGGCTAC AAAAAGCCAGAAGACCTCTA CACCGCCGTC 1651 GGACAAGGCG AAATTTCCAA CCGCGCCATC CAAAAAGCCTGCGGCACGCT 1701 GAACGAACCG CCGCCCGTGC CCGTCAGCGC AACCACCATC GTCAAACAGT1751 CCAAAATCAA AAAAGGTGGC AAAACCGGCG TGCTCATCGA CGGCGAAGAC 1801GGCTTGATGA CCACGCTTGC CAAATGCTGC AAACCCGCGC CGCCCGACGA 1851 TATTGCCGGCTTCGTTACCC GCGAGCGCGG CATTTCCGTC CACCGCAAAA 1901 CCTGCCCCTC TTTCCGACACCTTGCCGAAC ACGCGCCCGA AAAAGTACTG 1951 GACGCAAGTT GGGCGGCGTT GCAGGAAGGGCAAGTGTTCG CCGTCGATAT 2001 CGAAATCCGC GCCCAAGACC GCTCCGGGCT TTTGCGCGACGTATCCGACG 2051 CGCTCGCCCG CCACAAACTC AACGTTACCG CCGTGCAAAC CCAGTCCCGC2101 GACTTGGAAG CCAGCATGAG GTTCACGCTC GAAGTCAAAC AAGTCAACGA 2151CCTCCCGCGC GTCCTCGCCG GCCTCGGCGA TGTCAAAGGC GTATTGAGCG 2201 TTACCCGGCTTTAAThis corresponds to the amino acid sequence <SEQ ID 418; ORF 117-1.ng>:

g117-1.pep 1 MTAISPIQDT QSATLQELRE WFDSYCAALP DNDKNLIGTA WSLAQEHYPA 51DAATPYGEPL PDHFLGAAQM VDELDLLPDA VAATLLADIG RYVPDWNLLV 101 SERCNSTVAELVKGVDEVQK LTHFARVDSL ATPEERAQQA ETMRKMLLAM 151 VTDIRVVLIK LAMRTRTLQFLSNAPDSPEK RAVAKETLDI FAPLANRLGV 201 WQLKWQLEDL GFRHQEPEKY REIALLLDEKRTERLEYIEN FLDILRTELK 251 KYNIHFEVAG RPKHIYSIYK KMVKKKLSFD GLFDIRAVRILVDTVPECYT 301 TLGIVHSLWQ PIPGEFDDYI ANPKGNGYKS LHTVIVGPEE KGVEVQIRTF351 DMHQFNEFGV AAHWRYKEGG KGDSAYEQKI AWLRQLLDWR ENMAESGKED 401LAAAFKTELF NDTIYVLTPH GKVLSLPTGA TPIDFAYALH SSIGDRCRGA 451 KVEGQIVPLSTPLENGQRVE IITAKEGHPS VNWLYEGWVK SGKAIGKIRA 501 YIRQQNADTV REEGRVQLDKQLAKLTPKPN LQELAENLGY KKPEDLYTAV 551 GQGEISNRAI QKACGTLNEP PPVPVSATTIVKQSKIKKGG KTGVLIDGED 601 GLMTTLAKCC KPAPPDDIAG FVTRERGISV HRKTCPSFRHLAEHAPEKVL 651 DASWAALQEG QVFAVDIEIR AQDRSGLLRD VSDALARHKL NVTAVQTQSR701 DLEASMRFTL EVKQVNDLPR VLAGLGDVKG VLSVTRL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 419>:

m117-1.seq 1 ATGACCGCCA TCAGCCCGAT TCAAGACACG CAAAGCGCGA CTCTGCAAGA 51ATTGCGCGAA TGGTTCGACA GCTACTGCGC CGCTCTGCCG GACAACGATA 101 AAAACCTCATCGGTACCGCA TGGTTGCTGG CGCAGGAACA TTACCCCGCC 151 GATGCCGCCA CGCCGTATGGCGAGCCGCTG CCCGACCACT TCCTCGGCGC 201 GGCGCAAATG GTTCATGAAC TCGACCTGCTCCCCGATGCC GTCGCCGCCA 251 CCCTGCTTGC CGACATCGGA CGCTACGTCC CCGACTGGAACCTATTGGTT 301 TCCGAACGCT GCAACAGTAC CGTCGCCGAG CTGGTCAAAG GTGTGGACGA351 AGTGCAGAAA CTCACCCACT TCGCCCGGGT GGACAGCCTC GCCACGCCGG 401AAGAACGCGC CCAGCAGGCA GAAACTATGC GGAAAATGCT GCTGGCGATG 451 GTTACCGACATCCGCGTCGT GTTAATCAAA CTGGCGATGC GTACGCGCAC 501 CCTGCAATTT TTAAGCAACGCCCCCGACAG CCCCGAAAAA CGCGCCGTCG 551 CCAAAGAAAC CCTCGACATC TTCGCCCCGCTCGCCAACCG TTTGGGCGTG 601 TGGCAGCTCA AATGGCAGCT CGAAGATTTG GGCTTCCGCCATCAAAAGCC 651 CGAAAAATAC CGCGAAATCG CGCTGCTTTT GGACGAAAAA CGCACCGAAC701 GCCTCGAATA CATCGAAAAC TTCCTCAACA TCCTGCGCGG TGAACTCAAG 751AAATACAATG TCCATTTCGA AGTCGCCGGC CGCCCGAAAC ACATCTACTC 801 CATTTACAAAAAAATGGTGA AGAAAAAACT CAGCTTCGAC GGCCTCTTTG 851 ACATCCGCGC CGTGCGAATTCTGGTTGATA CCGTCCCCGA GTGTTACACC 901 ACGCTGGGTA TCGTCCACAG CCTCTGGCAGCCCATTCCCG GCGAGTTCGA 951 CGACTACATC GCCAATCCCA AAGGCAACGG CTATAAAAGTTTGCACACCG 1001 TCATCGTCGG CCCGGAAGAC AAAGGCGTGG AAGTACAAAT CCGCACCTTC1051 GATATGCACC AATTCAACGA ATTCGGTGTC GCCGCCCACT GGCGTTACAA 1101AGAGGGCGGC AAGGGCGATT CCGCCTACGA ACAGAAAATC GCCTGGTTGC 1151 GCCAACTCTTGGACTGGCGC GAAAACATGG CGGAAAGCGG CAAGGAAGAC 1201 CTCGCCGCCG CCTTCAAAACCGAGCTTTTC AACGACACGA TTTATGTTTT 1251 GACCCCGCAC GGCAAAGTCC TCTCCCTGCCCACGGGCGCG ACCCCCATCG 1301 ACTTCGCCTA CGCCCTGCAC AGCAGCATCG GCGACCGTTGCCGCGGTGCG 1351 AAAGTCGAAG GGCAGATTGT GCCGCTGTCC ACCCCGCTCG AAAACGGACA1401 GCGCGTCGAA ATCATTACCG CCAAAGAAGG GCATCCTTCC GTCAACTGGC 1451TTTACGAAGG CTGGGTCAAA TCCAACAAGG CAATCGGCAA AATCCGCGCC 1501 TACATCCGCCAGCAAAACGC CGACACCGTG CGCGAAGAAG GCCGCGTCCA 1551 ACTCGACAAA CAGCTTGCCAAACTCACGCC CAAACCCAAC CTGCAAGAGC 1601 TTGCCGAAAA TCTCGGCTAC AAAAAGCCAGAAGACCTCTA CACCGCCGTC 1651 GGACAAGGCG AAATTTCCAA CCGCGCCATC CAAAAAGCCTGCGGCACGCT 1701 GAACGAACCG CCGCCCGTAC CCGTCAGCGA AACCACCATC GTCAAACAGT1751 CCAAAATCAA AAAAGGCGGC AAAAACGGCG TGCTCATCGA CGGCGAAGAC 1801GGTCTGATGA CCACGCTTGC CAAATGCTGC AAACCCGCGC CGCCCGACGA 1851 TATTATCGGCTTCGTTACCC GCGAGCGCGG CATTTCAGTG CACCGCAAAA 1901 CCTGCCCGTC TTTCCAACACCTCGCCGAAC ACGCGCCCGA AAAAGTGCTG 1951 GACGCAAGCT GGGCGGCATT GCAGGAAGGACAAGTATTCG CCGTCGATAT 2001 CGAAATCCGC GCCCAAGACC GCTCCGGGCT TTTGCGCGACGTATCCGACG 2051 CGCTCGCCCG CCACAAACTC AACGTTACCG CCGTGCAAAC CCAGTCCCGC2101 GACTTGGAAG CCAGCATGAG GTTCACGCTC GAAGTCAAAC AAGTCAACGA 2151CCTCCCGCGC GTCCTCGCCA GCCTCGGCGA CGTCAAAGGC GTATTGAGCG 2201 TTACCCGGCTTTAAThis corresponds to the amino acid sequence <SEQ ID 420; ORF 117-1>:

m117-1.pep 1 MTAISPIQDT QSATLQELRE WFDSYCAALP DNDKNLIGTA WLLAQEHYPA 51DAATPYGEPL PDHFLGAAQM VHELDLLPDA VAATLLADIG RYVPDWNLLV 101 SERCNSTVAELVKGVDEVQK LTHFARVDSL ATPEERAQQA ETMRKMLLAM 151 VTDIRVVLIK LAMRTRTLQFLSNAPDSPEK RAVAKETLDI FAPLANRLGV 201 WQLKWQLEDL GFRHQKPEKY REIALLLDEKRTERLEYIEN FLNILRGELK 251 KYNVHFEVAG RPKHIYSIYK KMVKKKLSFD GLFDIRAVRILVDTVPECYT 301 TLGIVHSLWQ PIPGEFDDYI ANPKGNGYKS LHTVIVGPED KGVEVQIRTF351 DMHQFNEFGV AAHWRYKEGG KGDSAYEQKI AWLRQLLDWR ENMAESGKED 401LAAAFKTELF NDTIYVLTPH GKVLSLPTGA TPIDFAYALH SSIGDRCRGA 451 KVEGQIVPLSTPLENGQRVE IITAKEGHPS VNWLYEGWVK SNKAIGKIRA 501 YIRQQNADTV REEGRVQLDKQLAKLTPKPN LQELAENLGY KKPEDLYTAV 551 GQGEISNRAI QKACGTLNEP PPVPVSETTIVKQSKIKKGG KNGVLIDGED 601 GLMTTLAKCC KPAPPDDIIG FVTRERGISV HRKTCPSFQHLAEHAPEKVL 651 DASWAALQEG QVFAVDIEIR AQDRSGLLRD VSDALARHKL NVTAVQTQSR701 DLEASMRFTL EVKQVNDLPR VLASLGDVKG VLSVTRL* m117-1/g117-1 98.2%identity in 737 aa overlap        10        20        30        40        50        60 m117-1.pepMTAISPIQDTQSATLQELREWFDSYCAALPDNDKNLIGTAWLLAQEHYPADAATPYGEPL||||||||||||||||||||||||||||||||||||||||| |||||||||||||||||| g117-1MTAISPIQDTQSATLQELREWFDSYCAALPDNDKNLIGTAWSLAQEHYPADAATPYGEPL        10        20        30        40        50        60        70        80        90       100       110       120 m117-1.pepPDHFLGAAQMVHELDLLPDAVAATLLADIGRYVPDWNLLVSERCNSTVAELVKGVDEVQK||||||||||| |||||||||||||||||||||||||||||||||||||||||||||||| g117-1PDHFLGAAQMVDELDLLPDAVAATLLADIGRYVPDWNLLVSERCNSTVAELVKGVDEVQK        70        80        90       100       110       120       130       140       150       160       170       180 m117-1.pepLTHFARVDSLATPEERAQQAELMRKMLLAMVTDIRVVLIKLAMRTRTLQFLSNAPDSPEK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g117-1LTHFARVDSLATPEERAQQAELMRKMLLAMVTDIRVVLIKLAMRTRTLQFLSNAPDSPEK       130       140       150       160       170       180       190       200       210       220       230       240 m117-1.pepRAVAKETLDIFAPLANRLGVWQLKWQLEDLGFRHQKPEKYREIALLLDEKRTERLEYIEN|||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| g117-1RAVAKETLDIFAPLANRLGVWQLKWQLEDLGFRHQEPEKYREIALLLDEKRTERLEYIEN       190       200       210       220       230       240       250       260       270       280       290       300 m117-1.pepFLNILRGELKKYNVHFEVAGRPKHIYSIYKKMVKKKLSFDGLFDIRAVRILVDTVPECYT||:||| ||||||:|||||||||||||||||||||||||||||||||||||||||||||| g117-1FLDILRTELKKYNIHFEVAGRPKHIYSIYKKMVKKKLSFDGLFDIRAVRILVDTVPECYT       250       260       270       280       290       300       310       320       330       340       350       360 m117-1.pepTLGIVHSLWQPIPGEFDDYIANPKGNGYKSLHTVIVGPEDKGVEVQIRTFDMHQFNEFGV|||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||| g117-1TLGIVHSLWQPIPGEFDDYIANPKGNGYKSLHTVIVGPEEKGVEVQIRTFDMHQFNEFGV       310       320       330       340       350       360       370       380       390       400       410       420 m117-1.pepAAHWRYKEGGKGDSAYEQKIAWLRQLLDWRENMAESGKEDLAAAFKTELFNDTIYVLTPH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g117-1AAHWRYKEGGKGDSAYEQKIAWLRQLLDWRENMAESGKEDLAAAFKTELFNDTIYVLTPH       370       380       390       400       410       420       430       440       450       460       470       480 m117-1.pepGKVLSLPTGATPIDFAYALHSSIGDRCRGAKVEGQIVPLSTPLENGQRVEIITAKEGHPS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g117-1GKVLSLPTGATPIDFAYALHSSIGDRCRGAKVEGQIVPLSTPLENGQRVEIITAKEGHPS       430       440       450       460       470       480       490       500       510       520       530       540 m117-1.pepVNWLYEGWVKSNKAIGKIRAYIRQQNADTVREEGRVQLDKQLAKLTPKPNLQELAENLGY|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||| g117-1VNWLYEGWVKSGKAIGKIRAYIRQQNADTVREEGRVQLDKQLAKLTPKPNLQELAENLGY       490       500       510       520       530       540       550       560       570       580       590       600 m117-1.pepKKPEDLYTAVGQGEISNRAIQKACGTLNEPPPVPVSETTIVKQSKIKKGGKNGVLIDGED|||||||||||||||||||||||||||||||||||| ||||||||||||||:|||||||| g117-1KKPEDLYTAVGQGEISNRAIQKACGTLNEPPPVPVSATTIVKQSKIKKGGKTGVLIDGED       550       560       570       580       590       600       610       620       630       640       650       660 m117-1.pepGLMTTLAKCCKPAPPDDIIGFVTRERGISVHRKTCPSFQHLAEHAPEKVLDASWAALQEG|||||||||||||||||| |||||||||||||||||||:||||||||||||||||||||| g117-1GLMTTLAKCCKPAPPDDIAGFVTRERGISVHRKTCPSFRHLAEHAPEKVLDASWAALQEG       610       620       630       640       650       660       670       680       690       700       710       720 m117-1.pepQVFAVDIEIRAQDRSGLLRDVSDALARHKLNVTAVQTQSRDLEASMRFTLEVKQVNDLPR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g117-1QVFAVDIEIRAQDRSGLLRDVSDALARHKLNVTAVQTQSRDLEASMRFTLEVKQVNDLPR       670       680       690       700       710       720        730m117-1.pep VLASLGDVKGVLSVTRLX |||:|||||||||||||| g117-1VLAGLGDVKGVLSVTRLX        730 m117-1/ReLA sp|P55133|RELA_VIBSS GTPPYROPHOSPHOKINASE (ATP:GTP 3′-PYROPHOSPHOTRANSFERASE) (PPGPP SYNTHETASEI) >gi|537617 (U13769) ppGpp synthetase I [Vibrio sp.] Length = 744Score = 536 bits (1366), Expect = e−151 Identities = 288/685 (42%),Positives = 432/685 (63%), Gaps = 31/685 (4%) Query: 74LDLLPDAVAATLLADI---GRYVPDWNLLVSERCNSTVAELVKGVDEVQKLTHFARVDSL 130 L +  D+ A LL  +   G Y  D    + E  + T+  LV+GV+++  ++   ++ S Sbjct: 68LSMDADTLIAALLYPLVEGGCYSTD---ALKEEYSGTILHLVQGVEQMCAIS---QLKST 121 Query:131 ATPEERAQQAETMRKMLLAMVTDIRVVLIKLAMRTRTLQFLSNAPDSPEKRAVAKETLDI 190A    +A Q + +R+MLL+MV D R V+IKLA R   L+ + + PD   +RA A+E  +I Sbjct: 122AEETAQAAQVDNIRRMLLSMVDDFRCVVIKLAERICNLREVKDQPDEV-RRAAAQECANI 180 Query:191 FAPLANRLGVWQLKWQLEDLGFRHQKPEKYREIALLLDEKRTERLEYIENFLNILRGELK 250+APLANRLG+ QLKW++ED  FR+Q P+ Y++IA  L E+R +R +YI +F++ L   +K Sbjct: 181YAPLANRLGIGQLKWEIEDYAFRYQHPDTYKQIAKQLSERRIDREDYITHFVDDLSDAMK 240 Query:251 KYNVHFEVAGRPKHIYSIYKKMVKKKLSFDGLFDIRAVRILVDTVPECYTTLGIVHSLWQ 310  N+  EV GRPKHIYSI++KM KK L FD LFD+RAVRI+ + + +CY  LG+VH+ ++ Sbjct: 241ASNIRAEVQGRPKHIYSIWRKMQKKSLEFDELFDVRAVRIVAEELQDCYAALGVVHTKYR 300 Query:311 PIPGEFDDYIANPKGNGYKSLHTVIVGPEDKGVEVQIRTFDMHQFNEFGVAAHWRYKEG- 369  +PEFDDY+ANPK NGY+S+HTV++GPE K +E+QIRT  MH+ +E GVAAHW+YKEG Sbjct: 301HLPKEFDDYVANPKPNGYQSIHTVVLGPEGKTIEIQIRTKQMHEESELGVAAHWKYKEGT 360 Query:370 --GKGDSAYEQKIAWLRQLLDWRENMAESGKEDLAAAFKTELFNDTIYVLTPHGKVLSLP 427  G   SAY++KI WLR+LL W+E M++SG  ++    ++++F+D +Y  TP G V+ LP Sbjct: 361ASGGAQSAYDEKINWLRKLLAWQEEMSDSG--EMLDELRSQVFDDRVYAFTPKGDVVDLP 418 Query:428 TGATPIDFAYALHSSIGDRCRGAKVEGQIVPLSTPLENGQRVEIITAKEGHPSVNWLYE- 486+ ATP+DFAY +HS +G RC GAKVEG+IVP +  L+ G +VEIIT KE +PS +WL Sbjct: 419SNATPLDFAYHIHSEVGHRCIGAKVEGRIVPFTYHLQMGDQVEIITQKEPNPSRDWLNPN 478 Query:487 -GWVKSNKAIGKIRAYIRQQNADTVREEGRVQLDKQLAKL--TPKPNLQELAENLGYKKP 543 G+V S++A  K+ A+ R+Q+ D     G+  L+ +L K+  T K      A+    K P Sbjct: 479LGFVTSSRARAKVHAWFRKQDRDKNIIAGKEILEAELVKIHATLKDAQYYAAKRFNVKSP 538 Query:544 EDLYTAVGQGEIS-NRAIQKACGTLNEPPPVPVSETTIVKQSKI--------KKGGKNGV 594E+LY  +G G++  N+ I      +N+P      +  + K S+         KK  ++ V Sbjct: 539EELYAGIGSGDLRINQVINHINALVNKPTAEEEDQQLLEKLSEASNKQATSHKKPQRDAV 598 Query:595 LIDGEDGLMTTLAKCCKPAPPDDIIGFVTRERGISVHRKTCPSFQHLAEHAPEKVLDASW 654+++G D LMT LA+CC+P P DDI GFVT+ RGISVHR  C   + L  HAPE+++D  W Sbjct: 599VVEGVDNLMTHLARCCQPIPGDDIQGFVTQGRGISVHRMDCEQLEELRHHAPERIIDTVW 658 Query:655 AALQEGQVFAVDIEIRAQDRSGLLRDVSDALARHKLNVTAVQTQ--SRDLEASMRFTLEV 712     G  + + + + A +R+GLL+++++ L   K+ V  ++++   +   + M F LE+ Sbjct: 659GGGFVGN-YTITVRVTASERNGLLKELTNTLMNEKVKVAGMKSRVDYKKQMSIMDFELEL 717 Query:713 KQVNDLPRVLASLGDVKGVLSVTRL 737   +  L RVL  +  VK V    RL Sbjct: 718TDLEVLGRVLKRIEQVKDVAEAKRL 742The following partial DNA sequence was identified in N. meningitidis<SEQ ID 421>:

a117-1.seq 1 ATGACCGCCA TCAGCCCGAT TCAAGACACG CAAAGCGCGA CTCTGCAAGA 51ATTGCGCGAA TGGTTCGACA GCTACTGCAC CGCGCTGCCG AACAACGATA 101 AAAAACTTGTCTTAGCCGCC CGTTCGCTGG CGGAAGCACA TTACCCCGCC 151 GATGCCGCCA CGCCGTATGGCGAACCGCTG CCCGACCACT TCCTCGGCGC 201 GGCGCAAATG GTTCATGAAC TCGACCTGCTCCCCGATGCC GTCGCCGCCA 251 CCCTGCTTGC CGACATCGGA CGCTACGTCC CCGACTGGAACCTATTGGTT 301 TCCGAACGCT GCAACAGTAC CGTCGCCGAG CTGGTCAAAG GTGTGGACGA351 AGTGCAGAAA CTCACCCACT TCGCCCGGGT GGACAGCCTC GCCACGCCGG 401AAGAACGCGC CCAGCAGGCA GAAACTATGC GGAAAATGCT GCTGGCGATG 451 GTTACCGACATCCGCGTCGT GTTAATCAAA CTGGCGATGC GTACGCGCAC 501 CCTGCAATTT TTAAGCAACGCCCCCGACAG CCCCGAAAAA CGCGCCGTCG 551 CCAAAGAAAC CCTCGACATC TTCGCCCCGCTCGCCAACCG TTTGGGCGTG 601 TGGCAGCTCA AATGGCAGCT CGAAGATTTG GGCTTCCGCCATCAAGAACC 651 CGAAAAATAC CGCGAAATCG CCCTGCTTTT GGACGAAAAA CGCACCGAAC701 GCCTCGAATA CATCGAAAAC TTCCTTAATA TCCTGCGTAC GGAACTCAAA 751AAATACAATA TCCACTTTGA AGTCGCCGGC CGTCCGAAAC ACATCTACTC 801 CATTTACAAAAAAATGGTGA AGAAAAAACT CAGCTTCGAC GGGTTGTTCG 851 ACATCCGCGC CGTGCGGATTCTGGTTGATA CCGTCCCCGA GTGTTACACC 901 ACACTGGGCA TTGTCCACAG CCTCTGGCAGCCCATTCCCG GCGAGTTCGA 951 CGACTACATC GCCAACCCGA AAGGCAACGG CTATAAAAGTTTGCACACCG 1001 TCATCGTCGG CCCGGAAGAC AAAGGCGTGG AAGTGCAAAT CCGCACCTTC1051 GATATGCACC AATTCAACGA ATTCGGTGTC GCCGCGCACT GGCGTTACAA 1101AGAGGGCGGC AAAGGCGATT CCGCCTACGA ACAAAAAATC GCCTGGTTAC 1151 GCCAACTTTTGGACTGGCGC GAAAACATGG CGGAAAGCGG CAAGGAAGAC 1201 CTCGCCGCCG CCTTCAAAACCGAGCTTTTC AACGACACGA TTTATGTTTT 1251 GACCCCGCAC GGCAAAGTCC TCTCCCTGCCCACAGGCGCG ACCCCCATCG 1301 ACTTCGCCTA CGCCCTGCAC AGCAGCATCG GCGACCGTTGCCGCGGTGCG 1351 AAAGTCGAAG GGCAGATTGT GCCGCTGTCC ACCCCGCTCG AAAACGGACA1401 GCGTGTCGAA ATCATTACCG CCAAAGAAGG GCATCCTTCC GTCAACTGGC 1451TTTACGAAGG CTGGGTCAAA TCCAACAAGG CAATCGGCAA AATCCGCGCC 1501 TACATCCGCCAGCAAAACGC CGACACCGTG CGCGAAGAAG GCCGCGTCCA 1551 ACTCGACAAA CAGCTTGCCAAACTCACGCC CAAACCCAAC CTGCAAGAGC 1601 TTGCCGAAAA TCTCGGCTAC AAAAAGCCAGAAGACCTCTA CACCGCCGTC 1651 GGACAAGGCG AAATTTCCAA CCGCGCCATC CAAAAAGCCTGCGGCACGCT 1701 GAACGAACCG CCGCCCGTAC CCGTCAGCGA AACCACCATC GTCAAACAGT1751 CCAAAATCAA AAAAGGCGGC AAAAACGGCG TGCTCATCGA CGGCGAAGAC 1801GGTCTGATGA CCACGCTTGC CAAATGCTGC AAACCCGCGC CGCCCGACGA 1851 CATTGTCGGCTTCGTTACCC GCGATCGCGG CATTTCGGTA CACCGCAAAA 1901 CCTGCCCCTC TTTCCGACACCTCGCCGAAC ACGCGCCCGA AAAAGTACTG 1951 GACGCAAGTT GGGCGGCGTT GCAGGAAGGACAAGTGTTCG CCGTCGATAT 2001 CGAAATCCGC GCCCAAGACC GCTCCGGGCT TTTGCGCGACGTATCCGACG 2051 CGCTCGCCCG CCACAAACTC AACGTTACCG CCGTGCAAAC CCAGTCCCGC2101 GACTTGGAAG CCAGCATGAG GTTCACGCTC GAAGTCAAAC AAGTTACCGA 2151CCTCCCACGC GTCCTCGCCA GCCTCGGCGA CGTCAAAGGC GTATTGAGCG 2201 TTACCCGGCTTTAAThis corresponds to the amino acid sequence <SEQ ID 422; ORF 117-1.a>:

a117-1.pep 1 MTAISPIQDT QSATLQELRE WFDSYCTALP NNDKKLVLAA RSLAEAHYPA 51DAATPYGEPL PDHFLGAAQM VHELDLLPDA VAATLLADIG RYVPDWNLLV 101 SERCNSTVAELVKGVDEVQK LTHFARVDSL ATPEERAQQA ETMRKMLLAM 151 VTDIRVVLIK LAMRTRTLQFLSNAPDSPEK RAVAKETLDI FAPLANRLGV 201 WQLKWQLEDL GFRHQEPEKY REIALLLDEKRTERLEYIEN FLNILRTELK 251 KYNIHFEVAG RPKHIYSIYK KMVKKKLSFD GLFDIRAVRILVDTVPECYT 301 TLGIVHSLWQ PIPGEFDDYI ANPKGNGYKS LHTVIVGPED KGVEVQIRTF351 DMHQFNEFGV AAHWRYKEGG KGDSAYEQKI AWLRQLLDWR ENMAESGKED 401LAAAFKTELF NDTIYVLTPH GKVLSLPTGA TPIDFAYALH SSIGDRCRGA 451 KVEGQIVPLSTPLENGQRVE IITAKEGHPS VNWLYEGWVK SNKAIGKIRA 501 YIRQQNADTV REEGRVQLDKQLAKLTPKPN LQELAENLGY KKPEDLYTAV 551 GQGEISNRAI QKACGTLNEP PPVPVSETTIVKQSKIKKGG KNGVLIDGED 601 GLMTTLAKCC KPAPPDDIVG FVTRDRGISV HRKTCPSFRHLAEHAPEKVL 651 DASWAALQEG QVFAVDIEIR AQDRSGLLRD VSDALARHKL NVTAVQTQSR701 DLEASMRFTL EVKQVTDLPR VLASLGDVKG VLSVTRL* a117-1/m117-1 97.7%identity in 737 aa overlap        10        20        30        40        50        60 m117-1.pepMTAISPIQDTQSATLQELREWFDSYCAALPDNDKNLIGTAWLLAQEHYPADAATPYGEPL||||||||||||||||||||||||||:|||:|||:|: :|  ||: |||||||||||||| a117-1MTAISPIQDTQSATLQELREWFDSYCLALPNNDKKLVLAARSLAEAHYPADAATPYGEPL        10        20        30        40        50        60        70        80        90       100       110       120 m117-1.pepPDHFLGAAQMVHELDLLPDAVAATLLADIGRYVPDWNLLVSERCNSTVAELVKGVDEVQK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a117-1PDHFLGAAQMVHELDLLPDAVAATLLADIGRYVPDWNLLVSERCNSTVAELVKGVDEVQK        70        80        90       100       110       120       130       140       150       160       170       180 m117-1.pepLTHFARVDSLATPEERAQQAELMRKMLLAMVTDIRVVLIKLAMRTRTLQFLSNAPDSPEK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a117-1LTHFARVDSLATPEERAQQAELMRKMLLAMVTDIRVVLIKLAMRTRTLQFLSNAPDSPEK       130       140       150       160       170       180       190       200       210       220       230       240 m117-1.pepRAVAKETLDIFAPLANRLGVWQLKWQLEDLGFRHQKPEKYREIALLLDEKRTERLEYIEN|||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| a117-1RAVAKETLDIFAPLANRLGVWQLKWQLEDLGFRHQEPEKYREIALLLDEKRTERLEYIEN       190       200       210       220       230       240       250       260       270       280       290       300 m117-1.pepFLNILRGELKKYNVHFEVAGRPKHIYSIYKKMVKKKLSFDGLFDIRAVRILVDTVPECYT|||||| ||||||:|||||||||||||||||||||||||||||||||||||||||||||| a117-1FLNILRTELKKYNIHFEVAGRPKHIYSIYKKMVKKKLSFDGLFDIRAVRILVDTVPECYT       250       260       270       280       290       300       310       320       330       340       350       360 m117-1.pepTLGIVHSLWQPIPGEFDDYIANPKGNGYKSLHTVIVGPEDKGVEVQIRTFDMHQFNEFGV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a117-1TLGIVHSLWQPIPGEFDDYIANPKGNGYKSLHTVIVGPEDKGVEVQIRTFDMHQFNEFGV       310       320       330       340       350       360       370       380       390       400       410       420 m117-1.pepAAHWRYKEGGKGDSAYEQKIAWLRQLLDWRENMAESGKEDLAAAFKTELFNDTIYVLTPH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a117-1AAHWRYKEGGKGDSAYEQKIAWLRQLLDWRENMAESGKEDLAAAFKTELFNDTIYVLTPH       370       380       390       400       410       420       430       440       450       460       470       480 m117-1.pepGKVLSLPTGATPIDFAYALHSSIGDRCRGAKVEGQIVPLSTPLENGQRVEIITAKEGHPS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a117-1GKVLSLPTGATPIDFAYALHSSIGDRCRGAKVEGQIVPLSTPLENGQRVEIITAKEGHPS       430       440       450       460       470       480       490       500       510       520       530       540 m117-1.pepVNWLYEGWVKSNKAIGKIRAYIRQQNADTVREEGRVQLDKQLAKLTPKPNLQELAENLGY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a117-1VNWLYEGWVKSNKAIGKIRAYIRQQNADTVREEGRVQLDKQLAKLTPKPNLQELAENLGY       490       500       510       520       530       540       550       560       570       580       590       600 m117-1.pepKKPEDLYTAVGQGEISNRAIQKACGTLNEPPPVPVSETTIVKQSKIKKGGKNGVLIDGED|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a117-1KKPEDLYTAVGQGEISNRAIQKACGTLNEPPPVPVSETTIVKQSKIKKGGKNGVLIDGED       550       560       570       580       590       600       610       620       630       640       650       660 m117-1.pepGLMTTLAKCCKPAPPDDIIGFVTRERGISVHRKTCPSFQHLAEHAPEKVLDASWAALQEG||||||||||||||||||:|||||:|||||||||||||:||||||||||||||||||||| a117-1GLMTTLAKCCKPAPPDDIVGFVTRDRGISVHRKTCPSFRHLAEHAPEKVLDASWAALQEG       610       620       630       640       650       660       670       680       690       700       710       720 m117-1.pepQVFAVDIEIRAQDRSGLLRDVSDALARHKLNVTAVQTQSRDLEASMRFTLEVKQVNDLPR|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||| a117-1QVFAVDIEIRAQDRSGLLRDVSDALARHKLNVTAVQTQSRDLEASMRFTLEVKQVTDLPR       670       680       690       700       710       720        730m117-1.pep VLASLGDVKGVLSVTRLX |||||||||||||||||| a117-1VLASLGDVKGVLSVTRLX        730The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 423>:

g118.seq 1 ATGTGCGAGT TCAAGGATTT TAGAAGAAAC ATCCCTTGTT TTGAAGAGTA 51TGACGAAAAT TCATTTATTG GCAAATGGTA TGATGACGGG GTGTGGGATG 101 ATGAAGAATATTGGAAGCTG GAGAATGATT TAATcgaGGT TAGGAGAAAA 151 TATCCTTATC CGATGGATATACCAAGGGAT ATTGTGATTG GAATCGGTAC 201 CATTATTGAT TTTTTAATGG TTCCAAATTGGGAGCTTTTT GAAATTAAAG 251 CTTCCCCTTG GTTGCCTGAT AGCGTGGGAA TTCATGAACGTTATGAAAGA 301 TTCACAACGA TGCTCCGTTA TATTTTTACC GAGAAAGACA TAGTCAACGT351 GCGATTTGAT TATTACAaCA AAAAATAGThis corresponds to the amino acid sequence <SEQ ID 424; ORF 118.ng>:

g118.pep 1 MCEFKDFRRN IPCFEEYDEN SFIGKWYDDG VWDDEEYWKL ENDLIEVRRK 51YPYPMDIPRD IVIGIGTIID FLMVPNWELF EIKASPWLPD SVGIHERYER 101 FTTMLRYIFTEKDIVNVRFD YYNKK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 425>:

m118.seq 1 ATGTGTGAGT TCAAGGATAT TATAAGAAAC GTTCCTTATT TTGAGGGGTA 51TGACGAAAAT TCATTTATTG GCAAATGGTA TGATGACGGG GTGTGGGATG 101 ATGAAGAATATTGGAAGTTG GAGAATGATT TAATCGAGGT TAGAAAAAAA 151 TATCCTTATC CGATGGACATACCAAGATAT GTTGTCATTG GAATCGGTAC 201 CATTATTGAT TTCTTAATGG TTCCAAATTGGAAACTTTTT GAAATTAAAG 251 CTTCCCCTTG GTTGCCTGAT AGTGTGGGAA TTCATGAACGTTATGAAAGA 301 TTCACAACGA TGCTCCGTTA TATTTTTACC GAGAAAGACA TAGTCAACGT351 GCGATTTGAT TATTACAACA AAAAATAGThis corresponds to the amino acid sequence <SEQ ID 426; ORF 118>:

m118.pep 1 MCEFKDIIRN VPYFEGYDEN SFIGKWYDDG VWDDEEYWKL ENDLIEVRKK 51YPYPMDIPRY VVIGIGTIID FLMVPNWKLF EIKASPWLPD SVGIHERYER 101 FTTMLRYIFTEKDIVNVRFD YYNKK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 118 shows 92.8% identity over a 125 aa overlap with a predicted ORF(ORF 118.ng) from N. gonorrhoeae:

m118/g118         10        20        30        40        50        60m118.pep MCEFKDIIRNVPYFEGYDENSFIGKWYDDGVWDDEEYWKLENDLIEVRKKYPYPMDIPRY||||||: ||:| || ||||||||||||||||||||||||||||||||:|||||||||| g118MCEFKDFRRNIPCFEEYDENSFIGKWYDDGVWDDEEYWKLENDLIEVRRKYPYPMDIPRD        10        20        30        40        50        60        70        80        90       100       110       120 m118.pepVVIGIGTIIDFLMVPNWKLFEIKASPWLPDSVGIHERYERFTTMLRYIFTEKDIVNVRFD:||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||| g118IVIGIGTIIDFLMVPNWELFEIKASPWLPDSVGIHERYERFTTMLRYIFTEKDIVNVRFD        70        80        90       100       110       120 m118.pepYYNKKX |||||| g118 YYNKKXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 427>:

a118.seq 1 ATGTGTGAGT TCAAGGATTT TAGAAGAAAC ATCCCTTGTT TTGAAGAGTA 51TGACGAAAAT TCATTTATTG GCAAATGGTA TGATGACGGG GTGTGGGATG 101 ATGAAGAATATTGGAAATTG GAGAATGATT TAATCGAGGT TAGAAAAAAA 151 TATCCTTATC CGATGGATATACCAAGGGAT ATTGTGATTG GAATCGGTAC 201 CATTATTGAT TTTTTAATGG TTCCAAATTGGGAGCTTTTT GAAATTAAAG 251 CTTCCCCTTG GTTGCCTGAT AGTGTGGGAA TTCATGAACGTTATGAAAGA 301 TTCACAACGA TGCTCCGTTA TATTTTTACC GAGAAAGACA TAGTCAACGT351 GCGATTTGAT TATTACAACA AAAAATAGThis corresponds to the amino acid sequence <SEQ ID 428; ORF 118.a>:

a118.pep 1 MCEFKDFRRN IPCFEEYDEN SFIGKWYDDG VWDDEEYWKL ENDLIEVRKK 51YPYPMDIPRD IVIGIGTIID FLMVPNWELF EIKASPWLPD SVGIHERYER 101 FTTMLRYIFTEKDIVNVRFD YYNKK* m118/a118 93.6% identity in 125 aa overlap        10        20        30        40        50        60 m118.pepMCEFKDIIRNVPYFEGYDENSFIGKWYDDGVWDDEEYWKLENDLIEVRKKYPYPMDIPRY ||||||:||:| || ||||||||||||||||||||||||||||||||||||||||||| a118MCEFKDFRRNIPCFEEYDENSFIGKWYDDGVWDDEEYWKLENDLIEVRKKYPYPMDIPRD        10        20        30        40        50        60        70        80        90       100       110       120 m118.pepVVIGIGTIIDFLMVPNWKLFEIKASPWLPDSVGIHERYERFTTMLRYIFTEKDIVNVRFD:||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||| a118IVIGIGTIIDFLMVPNWELFEIKASPWLPDSVGIHERYERFTTMLRYIFTEKDIVNVRFD        70        80        90       100       110       120 m118.pepYYNKKX |||||| a118 YYNKKXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 429>:

g120.seq 1 ATGATGAAGA CTTTTAAAAA TATATTTTCC GCCGCCATTT TGTCCGCCGC 51CCTGCCGTGC GCGTATGCGG CAAGGCTACC CCAATCCGCC GTGCTGCACT 101 ATTCCGGCAGCTACGGCATT CCCGCCACGA TGACATTTGA ACGCAGCGGC 151 AATGCTTACA AAATCGTTTCGACGATTAAA GTGCCGCTAT ACAATATCCG 201 TTTCGAATCC GGCGGTACGG TTGTCGGCAATACCCTGCAC CCTGCCTACT 251 ATAAAGACAT ACGCAGGGGC AAACTGTATG CGGAAGCCAAATTCGCCGAC 301 GGCAGCGTAA CCTACGGCAA AGCGGGCGAG AGCAAAACCG AGCAAAGCCC351 CAAGGCTATG GATTTGTTCA CGCTTGCCTG GCAGTTGGCG GCAAATGACG 401CGAAACTCCC CCCGGGTCTG AAAATCACCA ACGGCAAAAA ACTTTATTCC 451 GTCGGCGGCCTGAATAAGGC GGGTACGGGA AAATACAGCA Taggcggcgt 501 gGAAACCGAA GTCGTCAAATATCGGGTGCG GCGCGGCGAC GATACGGTAA 551 CGTATTTCTT CGCACCGTCC CTGAACAATATTCCGGCACA AATCGGCTAT 601 ACCGAcgaCG GCAAAACCTA TACGCTGAAG CTCAAATCGGTGCAGATCAA 651 CGGACAGGCC GCCAAACCGT AAThis corresponds to the amino acid sequence <SEQ ID 430; ORF 120.ng>:

g120.pep 1 MMKTFKNIFS AAILSAALPC AYAARLPQSA VLHYSGSYGI PATMTFERSG 51NAYKIVSTIK VPLYNIRFES GGTVVGNTLH PAYYKDIRRG KLYAEAKFAD 101 GSVTYGKAGESKTEQSPKAM DLFTLAWQLA ANDAKLPPGL KITNGKKLYS 151 VGGLNKAGTG KYSIGGVETEVVKYRVRRGD DTVTYFFAPS LNNIPAQIGY 201 TDDGKTYTLK LKSVQINGQA AKP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 431>:

m120.seq 1 ATGATGAAGA CTTTTAAAAA TATATTTTCC GCCGCCATTT TGTCCGCCGC 51CCTGCCGTGC GCGTATGCGG CAGGGCTGCC CCAATCCGCC GTGCTGmACT 101 ATTCCGGCAGCTACGGCATT CCCGCCACGA TGACATTTGA ACGCAGCGGC 151 AATGCTTACA AAATCGTTTCGACGATTAAA GTGCCGCTAT ACAATATCCG 201 TTTCGAGTCC GGCGGTACGG TTGTCGGCAATACCCTGCAC CCTACCTACT 251 ATAGAGACAT ACGCAGGGGC AAACTGTATG CGGAAGCcAAATTCGCCGAC 301 GGCAGCGTAA CTTACGGCAA AGCGGGCGAG AGCAAAACCG AGCAAAGCCC351 CAAGGCTATG GATTTGTTCA CGCTTGCCTG GCAGTTGGCG GCAAATGACG 401CGAAACTCCC CCCGGGGCTG AAAATCACCA ACGGCAAAAA ACTTTATTCC 451 GTCGGCGGTTTGAATAAGGC GGGTACAGGA AAATACAGCA TAGGCGGCGT 501 GGAAACCGAA GTCGTCAAATATCGGGTGCG GCGCGGCGAC GATGCGGTAA 551 TGTATTTCTT CGCACCGTCC CTGAACAATATTCCGGCACA AATCGGCTAT 601 ACCGACGACG GCAAAACCTA TACGCTGAAA CTCAAATCGGTGCAGATCAA 651 CGGCCAGGCA GCCAAACCGThis corresponds to the amino acid sequence <SEQ ID 432; ORF 120>:

m120.pep 1 MMKTFKNIFS AAILSAALPC AYAAGLPQSA VLXYSGSYGI PATMTFERSG 51NAYKIVSTIK VPLYNIRFES GGTVVGNTLH PTYYRDIRRG KLYAEAKFAD 101 GSVTYGKAGESKTEQSPKAM DLFTLAWQLA ANDAKLPPGL KITNGKKLYS 151 VGGLNKAGTG KYSIGGVETEVVKYRVRRGD DAVMYFFAPS LNNIPAQIGY 201 TDDGKTYTLK LKSVQINGQA AKPComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 120 shows 97.3% identity over a 223 aa overlap with a predicted ORF(ORF 120.ng) from N. gonorrhoeae:

m120/g120         10        20        30        40        50        60m120.pep MMKTFKNIFSAAILSAALPCAYAAGLPQSAVLXYSGSYGIPATMTFERSGNAYKIVSTIK|||||||||||||||||||||||| ||||||| ||||||||||||||||||||||||||| g120MMKTFKNIFSAAILSAALPCAYAARLPQSAVLHYSGSYGIPATMTFERSGNAYKIVSTIK        10        20        30        40        50        60        70        80        90       100       110       120 m120.pepVPLYNIRFESGGTVVGNTLHPTYYRDIRRGKLYAEAKFADGSVTYGKAGESKTEQSPKAM|||||||||||||||||||||:||:||||||||||||||||||||||||||||||||||| g120VPLYNIRFESGGTVVGNTLHPAYYKDIRRGKLYAEAKFADGSVTYGKAGESKTEQSPKAM        70        80        90       100       110       120       130       140       150       160       170       180 m120.pepDLFTLAWQLAANDAKLPPGLKITNGKKLYSVGGLNKAGTGKYSIGGVETEVVKYRVRRGD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g120DLFTLAWQLAANDAKLPPGLKITNGKKLYSVGGLNKAGTGKYSIGGVETEVVKYRVRRGD       130       140       150       160       170       180       190       200       210       220 m120.pepDAVMYFFAPSLNNIPAQIGYTDDGKTYTLKLKSVQINGQAAKP|:| ||||||||||||||||||||||||||||||||||||||| g120DTVTYFFAPSLNNIPAQIGYTDDGKTYTLKLKSVQINGQAAKPX       190       200       210       220The following partial DNA sequence was identified in N. meningitidis<SEQ ID 433>:

a120.seq 1 ATGATGAAGA CTTTTAAAAA TATATTTTCC GCCGCCATTT TGTCCGCCGC 51CCTGCCGTGC GCGTATGCGG CAGGGCTGCC CCAATCCGCC GTGCTGCACT 101 ATTCCGGCAGCTACGGCATT CCCGCCACGA TGACATTTGA ACGCAGCGGC 151 AATGCTTACA AAATCGTTTCGACGATTAAA GTGCCGCTAT ACAATATCCG 201 TTTCGAGTCC GGCGGTACGG TTGTCGGCAATACCCTGCAC CCTACCTACT 251 ATAGAGACAT ACGCAGGGGC AAACTGTATG CGGAAGCCAAATTCGCCGAC 301 GGCAGCGTAA CCTACGGCAA AGCGGGCGAG AGCAAAACCG AGCAAAGCCC351 CAAGGCTATG GATTTGTTCA CGCTTGCCTG GCAGTTGGCG GCAAATGACG 401CGAAACTCCC CCCGGGGCTG AAAATCACCA ACGGCAAAAA ACTTTATTCC 451 GTCGGCGGTTTGAATAAGGC GGGTACAGGA AAATACAGCA TAGGCGGCGT 501 GGAAACCGAA GTCGTCAAATATCGGGTGCG GCGCGGCGAC GATGCGGTAA 551 TGTATTTCTT CGCACCGTCC CTGAACAATATTCCGGCACA AATCGGCTAT 601 ACCGACGACG GCAAAACCTA TACGCTGAAA CTCAAATCGGTGCAGATCAA 651 CGGCCAGGCA GCCAAACCGT AAThis corresponds to the amino acid sequence <SEQ ID 434; ORF 120.a>:

a120.pep 1 MMKTFKNIFS AAILSAALPC AYAAGLPQSA VLHYSGSYGI PATMTFERSG 51NAYKIVSTIK VPLYNIRFES GGTVVGNTLH PTYYRDIRRG KLYAEAKFAD 101 GSVTYGKAGESKTEQSPKAM DLFTLAWQLA ANDAKLPPGL KITNGKKLYS 151 VGGLNKAGTG KYSIGGVETEVVKYRVRRGD DAVMYFFAPS LNNIPAQIGY 201 TDDGKTYTLK LKSVQINGQA AKP*m120/a120 99.6% identity in 223 aa overlap        10        20        30        40        50        60 m120.pepMMKTFKNIFSAAILSAALPCAYAAGLPQSAVLXYSGSYGIPATMTFERSGNAYKIVSTIK|||||||||||||||||||||||||||||||| ||||||||||||||||||||||||||| a120MMKTFKNIFSAAILSAALPCAYAAGLPQSAVLHYSGSYGIPATMTFERSGNAYKIVSTIK        10        20        30        40        50        60        70        80        90       100       110       120 m120.pepVPLYNIRFESGGTVVGNTLHPTYYRDIRRGKLYAEAKFADGSVTYGKAGESKTEQSPKAM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a120VPLYNIRFESGGTVVGNTLHPTYYRDIRRGKLYAEAKFADGSVTYGKAGESKTEQSPKAM        70        80        90       100       110       120       130       140       150       160       170       180 m120.pepDLFTLAWQLAANDAKLPPGLKITNGKKLYSVGGLNKAGTGKYSIGGVETEVVKYRVRRGD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a120DLFTLAWQLAANDAKLPPGLKITNGKKLYSVGGLNKAGTGKYSIGGVETEVVKYRVRRGD       130       140       150       160       170       180       190       200       210       220 m120.pepDAVMYFFAPSLNNIPAQIGYTDDGKTYTLKLKSVQINGQAAKPX|||||||||||||||||||||||||||||||||||||||||||| a120DAVMYFFAPSLNNIPAQIGYTDDGKTYTLKLKSVQINGQAAKPX       190       200       210       220The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 435>:

g121.seq 1 ATGGAAACAC AGCTTTACAT CGGCATTATG TCGGGAACCA GTATGGACGG 51GGCGGATGCC GTGCTGGTAC GGATGGACGG CGGCAAATGG CTGGGCGCGG 101 AAGGGCACGCCTTTACCCCC TACCCTGACC GGTTGCGCCG CAAATTGCTG 151 GATTTGCAGG ACACAGGCACAGACGAACTG CACCGCAGCA GGATGTTGTC 201 GCAAGAACTC AGCCGCCTGT ACGCGCAAACCGCCGCCGAA CTGCTGTGCA 251 GTCAAAACCT CGCTCCGTGC GACATTACCG CCCTCGGCTGCCACGGGCAA 301 ACCGTCCGAC ACGCGCCGGA ACACGGTtac AGCATACAGC TTGCCGATTT351 GCCGCTGCTG GCGGAACTGa cgcggatttT TACCGTCggc gacttcCGCA 401GCCGCGACCT TGCTGCCGGC GGacaAGGTG CGCCGCTCGT CCCCGCCTTT 451 CACGAAGCCCTGTTCCGCGA TGACAGGGAA ACACGCGTGG TACTGAACAT 501 CGGCGGGATT GCCAACATCAGCGTACTCCC CCCCGGCGCA CCCGCCTTCG 551 GCTTCGACAC AGGGCCGGGC AATATGCTGATGGAcgcgtg gacgcaggca 601 cacTGGcagc TGCCTTACGA CAAAAacggt gcAAAGgcggcacAAGGCAA 651 catatTGCcg cAACTGCTCG gcaggctGCT CGCCcaccCG TATTTCTCAC701 AACCCcaccc aaAAAGCACG GGgcGCGaac TgtttgcccT AAattggctc 751gaaacctAcc ttgacggcgg cgaaaaccga tacgacgtat tgcggacgct 801 ttcccgattcaccgcgcaaA ccgTttggga cgccgtctca CACGCAGCGG 851 CAGATGCCCG TCAAATGTACATTTGCGGCG GCGGCATCCG CAATCCTGTT 901 TTAATGGCGG ATTTGGCAGA ATGTTTCGGCACACGCGTTT CCCTGCACAG 951 CACCGCCGAA CTGAACCTCG ATCCTCAATG GGTGGAGGCGgccgCATTtg 1001 cgtggttggC GGCGTGTTGG ATTAACCGCA TTCCCGGTAG TCCGCACAAA1051 GCGACCGGCG CATCCAAACC GTGTATTCTG GGCGCGGGAT ATTATTATTG 1101 AThis corresponds to the amino acid sequence <SEQ ID 436; ORF 121.ng>:

g121.pep 1 METQLYIGIM SGTSMDGADA VLVRMDGGKW LGAEGHAFTP YPDRLRRKLL 51DLQDTGTDEL HRSRMLSQEL SRLYAQTAAE LLCSQNLAPC DITALGCHGQ 101 TVRHAPEHGYSIQLADLPLL AELTRIFTVG DFRSRDLAAG GQGAPLVPAF 151 HEALFRDDRE TRVVLNIGGIANISVLPPGA PAFGFDTGPG NMLMDAWTQA 201 HWQLPYDKNG AKAAQGNILP QLLGRLLAHPYFSQPHPKST GRELFALNWL 251 ETYLDGGENR YDVLRTLSRF TAQTVWDAVS HAAADARQMYICGGGIRNPV 301 LMADLAECFG TRVSLHSTAE LNLDPQWVEA AAFAWLAACW INRIPGSPHK351 ATGASKPCIL GAGYYY*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 437>:

m121.seq 1 ATGGAAACAC AGCTTTACAT CGGCATCATG TCGGGAACCA GCATGGACGG 51GGCGGATGCC GTACTGATAC GGATGGACGG CGGCAAATGG CTGGGCGCGG 101 AAGGGCACGCCTTTACCCCC TACCCCGGCA GGTTACGCCG CCAATTGCTG 151 GATTTGCAGG ACACAGGCGCAGACGAACTG CACCGCAGCA GGATTTTGTC 201 GCAAGAACTC AGCCGCCTAT ATGCGCAAACCGCCGCCGAA CTGCTGTGCA 251 GTCAAAACCT CGCACCGTCC GACATTACCG CCCTCGGCTGCCACGGGCAA 301 ACCGTCCGAC ACGCGCCGGA ACACGGTTAC AGCATACAGC TTGCCGATTT351 GCCGCTGCTG GCGxxxxxxx xxxxxxxxxx xxxxxxxxxx xxxxxxxxxx 401xxxxxxxxxx xxxxxxxxxx xxxxxxxxxx xxxxxxxxxx xxxxxxxxxx 451 xxxxxxxxxxxxxxxxxxxx xxxxxxxxxx xxxxxxxxxx xxxxxxxxxx 501 xxxxxxxxxx xxxxxxxxxxxxxxxxxxxx xxxxxxxxxx xxxxxxxxxx 551 xxxxxxxxxx xxxxxxxxxx xxxxxxxxxxxxxxxxxxxx xxxxxxxxxx 601 xxxxxxCAGC TTCCTTACGA CAAAAACGGT GCAAAGTCGGCACAAGGCAA 651 CATATTGCCG CAACTGCTCG ACAGGCTGCT CGCCCACCCG TATTTCGCAC701 AACGCCACCC TAAAAGCACG GGGCGCGAAC TGTTTGCCAT AAATTGGCTC 751GAAACCTACC TTGACGGCGG CGAAAACCGA TACGACGTAT TGCGGACGCT 801 TTCCCGTTTTACCGCGCAAA CCGTTTGCGA CGCCGTCTCA CACGCAGCGG 851 CAGATGCCCG TCAAATGTACATTTGCGACG GCGGCATCCG CAATCCTGTT 901 TTAATGGCGG ATTTGGCAGA ATGTTTCGGCACACGCGTTT CCCTGCACAG 951 CACCGCCGAC CTGAACCTCG ATCCGCAATG GGTGGAAGCCGCCGnATTTG 1001 CGTGGTTGGC GGCGTGTTGG ATTAATCGCA TTCCCGGTAG TCCGCACAAA1051 GCAACCGGCG CATCCAAACC GTGTATTCTG AnCGCGGGAT ATTATTATTG 1101 AThis corresponds to the amino acid sequence <SEQ ID 438; ORF 121>:

m121.pep 1 METQLYIGIM SGTSMDGADA VLIRMDGGKW LGAEGHAFTP YPGRLRRQLL 51DLQDTGADEL HRSRILSQEL SRLYAQTAAE LLCSQNLAPS DITALGCHGQ 101 TVRHAPEHGYSIQLADLPLL Axxxxxxxxx xxxxxxxxxx xxxxxxxxxx 151 xxxxxxxxxx xxxxxxxxxxxxxxxxxxxx xxxxxxxxxx xxxxxxxxxx 201 xxQLPYDKNG AKSAQGNILP QLLDRLLAHPYFAQRHPKST GRELFAINWL 251 ETYLDGGENR YDVLRTLSRF TAQTVCDAVS HAAADARQMYICDGGIRNPV 301 LMADLAECFG TRVSLHSTAD LNLDPQWVEA AXFAWLAACW INRIPGSPHK351 ATGASKPCIL XAGYYY*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 121 shows 73.5% identity over a 366 aa overlap with a predicted ORF(ORF121.ng) from N. gonorrhoeae:

m121/g121         10        20        30        40        50        60m121.pep METQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRQLLDLQDTGADEL||||||||||||||||||||||:||||||||||||||||||| ||||:||||||||:||| g121METQLYIGIMSGTSMDGADAVLVRMDGGKWLGAEGHAFTPYPDRLRRKLLDLQDTGTDEL        10        20        30        40        50        60        70        80        90       100       110       120 m121.pepHRSRILSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHGYSIQLADLPLL||||:|||||||||||||||||||||||| |||||||||||||||||||||||||||||| g121HRSRMLSQELSRLYAQTAAELLCSQNLAPCDITALGCHGQTVRHAPEHGYSIQLADLPLL        70        80        90       100       110       120       130       140       150       160       170       180 m121.pepAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX|  :   :                                : g121AELTRIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDDRETRVVLNIGGIANISVLPPGA       130       140       150       160       170       180       190       200       210       220       230       240 m121.pepXXXXXXXXXXXXXXXXXXXXXXQLPYDKNGAKSAQGNILPQLLDRLLAHPYFAQRHPKST      :          :    ||||||||||:|||||||||| ||||||||:| ||||| g121PAFGFDTGPGNMLMDAWTQAHWQLPYDKNGAKAAQGNILPQLLGRLLAHPYFSQPHPKST       190       200       210       220       230       240       250       260       270       280       290       300 m121.pepGRELFAINWLETYLDGGENRYDVLRTLSRFTAQTVCDAVSHAAADARQMYICDGGIRNPV||||||:|||||||||||||||||||||||||||| |||||||||||||||| ||||||| g121GRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVWDAVSHAAADARQMYICGGGIRNPV       250       260       270       280       290       300       310       320       330       340       350       360 m121.pepLMADLAECFGTRVSLHSTADLNLDPQWVEAAXFAWLAACWINRIPGSPHKATGASKPCIL|||||||||||||||||||:||||||||||| |||||||||||||||||||||||||||| g121LMADLAECFGTRVSLHSTAELNLDPQWVEAAAFAWLAACWINRIPGSPHKATGASKPCIL       310       320       330       340       350       360 m121.pepXAGYYYX  |||||| g121 GAGYYYXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 439>:

a121.seq 1 ATGGAAACAC AGCTTTACAT CGGCATCATG TCGGGAACCA GCATGGACGG 51GGCGGATGCC GTACTGATAC GGATGGACGG CGGCAAATGG CTGGGCGCGG 101 AAGGGCACGCCTTTACCCCC TACCCCGGCA GGTTACGCCG CAAATTGCTG 151 GATTTGCAGG ACACAGGCGCGGACGAACTG CACCGCAGCA GGATGTTGTC 201 GCAAGAACTC AGCCGCCTGT ACGCGCAAACCGCCGCCGAA CTGCTGTGCA 251 GTCAAAACCT CGCGCCGTCC GACATTACCG CCCTCGGCTGCCACGGGCAA 301 ACCGTCAGAC ACGCGCCGGA ACACAGTTAC AGCGTACAGC TTGCCGATTT351 GCCGCTGCTG GCGGAACGGA CTCAGATTTT TACCGTCGGC GACTTCCGCA 401GCCGCGACCT TGCGGCCGGC GGACAAGGCG CGCCGCTCGT CCCCGCCTTT 451 CACGAAGCCCTGTTCCGCGA CGACAGGGAA ACACGCGCGG TACTGAACAT 501 CGGCGGGATT GCCAACATCAGCGTACTCCC CCCCGACGCA CCCGCCTTCG 551 GCTTCGACAC AGGACCGGGC AATATGCTGATGGACGCGTG GATGCAGGCA 601 CACTGGCAGC TTCCTTACGA CAAAAACGGT GCAAAGGCGGCACAAGGCAA 651 CATATTGCCG CAACTGCTCG ACAGGCTGCT CGCCCACCCG TATTTCGCAC701 AACCCCACCC TAAAAGCACG GGGCGCGAAC TGTTTGCCCT AAATTGGCTC 751GAAACCTACC TTGACGGCGG CGAAAACCGA TACGACGTAT TGCGGACGCT 801 TTCCCGATTCACCGCGCAAA CCGTTTTCGA CGCCGTCTCA CACGCAGCGG 851 CAGATGCCCG TCAAATGTACATTTGCGGCG GCGGCATCCG CAATCCTGTT 901 TTAATGGCGG ATTTGGCAGA ATGTTTCGGCACACGCGTTT CCCTGCACAG 951 CACCGCCGAA CTGAACCTCG ATCCGCAATG GGTAGAAGCCGCCGCGTTCG 1001 CATGGATGGC GGCGTGTTGG GTCAACCGCA TTCCCGGTAG TCCGCACAAA1051 GCAACCGGCG CATCCAAACC GTGTATTCTG GGCGCGGGAT ATTATTATTG 1101 AThis corresponds to the amino acid sequence <SEQ ID 440; ORF 121.a>:

a121.pep 1 METQLYIGIM SGTSMDGADA VLIRMDGGKW LGAEGHAFTP YPGRLRRKLL 51DLQDTGADEL HRSRMLSQEL SRLYAQTAAE LLCSQNLAPS DITALGCHGQ 101 TVRHAPEHSYSVQLADLPLL AERTQIFTVG DFRSRDLAAG GQGAPLVPAF 151 HEALFRDDRE TRAVLNIGGIANISVLPPDA PAFGFDTGPG NMLMDAWMQA 201 HWQLPYDKNG AKAAQGNILP QLLDRLLAHPYFAQPHPKST GRELFALNWL 251 ETYLDGGENR YDVLRTLSRF TAQTVFDAVS HAAADARQMYICGGGIRNPV 301 LMADLAECFG TRVSLHSTAE LNLDPQWVEA AAFAWMAACW VNRIPGSPHK351 ATGASKPCIL GAGYYY* m121/a121 74.0% identity in 366 aa overlap        10        20        30        40        50        60 m121.pepMETQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRQLLDLQDTGADEL|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||| a121METQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRKLLDLQDTGADEL        10        20        30        40        50        60        70        80        90       100       110       120 m121.pepHRSRILSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHGYSIQLADLPLL||||:|||||||||||||||||||||||||||||||||||||||||||:||:|||||||| a121HRSRMLSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHSYSVQLADLPLL        70        80        90       100       110       120       130       140       150       160       170       180 m121.pepAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX|  :|||:                                : a121AERTQIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDDRETRAVLNIGGIANISVLPPDA       130       140       150       160       170       180       190       200       210       220       230       240 m121.pepXXXXXXXXXXXXXXXXXXXXXXQLPYDKNGAKSAQGNILPQLLDRLLAHPYFAQRHPKST      :               ||||||||||:||||||||||||||||||||| |||| a121PAFGFDTGPGNMLMDAWMQAHWQLPYDKNGAKAAQGNILPQLLDRLLAHPYFAQPHPKST       190       200       210       220       230       240       250       260       270       280       290       300 m121.pepGRELFAINWLETYLDGGENRYDVLRTLSRFTAQTVCDAVSHAAADARQMYICDGGIRNPV||||||:|||||||||||||||||||||||||||| ||||||||||||||| |||||| a121GRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVFDAVSHAAADARQMYICGGGIRNPV       250       260       270       280       290       300       310       320       330       340       350       360 m121.pepLMADLAECFGTRVSLHSTADLNLDPQWVEAAXFAWLAACWINRIPGSPHKATGASKPCIL|||||||||||||||||||:||||||||||| ||:||||:||||||||||||||||||| a121LMADLAECFGTRVSLHSTAELNLDPQWVEAAAFAWMAACWVNRIPGSPHKATGASKPCIL       310       320       330       340       350       360 m121.pepXAGYYYX  |||||| a121 GAGYYYXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 441>:

m121-1.seq 1 ATGGAAACAC AGCTTTACAT CGGCATCATG TCGGGAACCA GCATGGACGG 51GGCGGATGCC GTACTGATAC GGATGGACGG CGGCAAATGG CTGGGCGCGG 101 AAGGGCACGCCTTTACCCCC TACCCCGGCA GGTTACGCCG CCAATTGCTG 151 GATTTGCAGG ACACAGGCGCAGACGAACTG CACCGCAGCA GGATTTTGTC 201 GCAAGAACTC AGCCGCCTAT ATGCGCAAACCGCCGCCGAA CTGCTGTGCA 251 GTCAAAACCT CGCACCGTCC GACATTACCG CCCTCGGCTGCCACGGGCAA 301 ACCGTCCGAC ACGCGCCGGA ACACGGTTAC AGCATACAGC TTGCCGATTT351 GCCGCTGCTG GCGGAACGGA CGCGGATTTT TACCGTCGGC GACTTCCGCA 401GCCGCGACCT TGCGGCCGGC GGACAAGGCG CGCCACTCGT CCCCGCCTTT 451 CACGAAGCCCTGTTCCGCGA CAACAGGGAA ACACGCGCGG TACTGAACAT 501 CGGCGGGATT GCCAACATCAGCGTACTCCC CCCCGACGCA CCCGCCTTCG 551 GCTTCGACAC AGGGCCGGGC AATATGCTGATGGACGCGTG GACGCAGGCA 601 CACTGGCAGC TTCCTTACGA CAAAAACGGT GCAAAGGCGGCACAAGGCAA 651 CATATTGCCG CAACTGCTCG ACAGGCTGCT CGCCCACCCG TATTTCGCAC701 AACCCCACCC TAAAAGCACG GGGCGCGAAC TGTTTGCCCT AAATTGGCTC 751GAAACCTACC TTGACGGCGG CGAAAACCGA TACGACGTAT TGCGGACGCT 801 TTCCCGTTTTACCGCGCAAA CCGTTTGCGA CGCCGTCTCA CACGCAGCGG 851 CAGATGCCCG TCAAATGTACATTTGCGGCG GCGGCATCCG CAATCCTGTT 901 TTAATGGCGG ATTTGGCAGA ATGTTTCGGCACACGCGTTT CCCTGCACAG 951 CACCGCCGAC CTGAACCTCG ATCCGCAATG GGTGGAAGCCGCCGNATTTG 1001 CGTGGTTGGC GGCGTGTTGG ATTAATCGCA TTCCCGGTAG TCCGCACAAA1051 GCAACCGGCG CATCCAAACC GTGTATTCTG ANCGCGGGAT ATTATTATTG 1101 AThis corresponds to the amino acid sequence <SEQ ID 442; ORF 121-1>:

m121-1.pep 1 METQLYIGIM SGTSMDGADA VLIRMDGGKW LGAEGHAFTP YPGRLRRQLL 51DLQDTGADEL HRSRILSQEL SRLYAQTAAE LLCSQNLAPS DITALGCHGQ 101 TVRHAPEHGYSIQLADLPLL AERTRIFTVG DFRSRDLAAG GQGAPLVPAF 151 HEALFRDNRE TRAVLNIGGIANISVLPPDA PAFGFDTGPG NMLMDAWTQA 201 HWQLPYDKNG AKAAQGNILP QLLDRLLAHPYFAQPHPKST GRELFALNWL 251 ETYLDGGENR YDVLRTLSRF TAQTVCDAVS HAAADARQMYICGGGIRNPV 301 LMADLAECFG TRVSLHSTAD LNLDPQWVEA AXFAWLAACW INRIPGSPHK351 ATGASKPCIL XAGYYY* m121-1/g121 95.6% identity in 366 aa overlap        10        20        30        40        50        60 m121-1.pepMETQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRQLLDLQDTGADEL||||||||||||||||||||||:||||||||||||||||||| |||:||||||||:||| g121METQLYIGIMSGTSMDGADAVLVRMDGGKWLGAEGHAFTPYPDRLRRKLLDLQDTGTDEL        10        20        30        40        50        60        70        80        90       100       110       120 m121-1.pepHRSRILSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHGYSIQLADLPLL||||:|||||||||||||||||||||||| ||||||||||||||||||||||||||||| g121HRSRMLSQELSRLYAQTAAELLCSQNLAPCDITALGCHGQTVRHAPEHGYSIQLADLPLL        70        80        90       100       110       120       130       140       150       160       170       180 m121-1.pepAERTRIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDNRETRAVLNIGGIANISVLPPDA|| ||||||||||||||||||||||||||||||||||:||||:||||||||||||||| | g121AELTRIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDDRETRVVLNIGGIANISVLPPGA       130       140       150       160       170       180       190       200       210       220       230       240 m121-1.pepPAFGFDTGPGNMLMDAWTQAHWQLPYDKNGAKAAQGNILPQLLDRLLAHPYFAQPHPKST||||||||||||||||||||||||||||||||||||||||||| ||||||||:||||||| g121PAFGFDTGPGNMLMDAWTQAHWQLPYDKNGAKAAQGNILPQLLGRLLAHPYFSQPHPKST       190       200       210       220       230       240       250       260       270       280       290       300 m121-1.pepGRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVCDAVSHAAADARQMYICGGGIRNPV||||||||||||||||||||||||||||||||||| |||||||||||||||||||||||| g121GRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVWDAVSHAAADARQMYICGGGIRNPV       250       260       270       280       290       300       310       320       330       340       350       360 m121-1.pepLMADLAECFGTRVSLHSTADLNLDPQWVEAAXFAWLAACWINRIPGSPHKATGASKPCIL|||||||||||||||||||:||||||||||| |||||||||||||||||||||||||||| g121LMADLAECFGTRVSLHSTAELNLDPQWVEAAAFAWLAACWINRIPGSPHKATGASKPCIL       310       320       330       340       350       360 m121-1.pepXAGYYYX  |||||| g121 GAGYYYXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 443>:

a121-1.seq 1 ATGGAAACAC AGCTTTACAT CGGCATCATG TCGGGAACCA GCATGGACGG 51GGCGGATGCC GTACTGATAC GGATGGACGG CGGCAAATGG CTGGGCGCGG 101 AAGGGCACGCCTTTACCCCC TACCCCGGCA GGTTACGCCG CAAATTGCTG 151 GATTTGCAGG ACACAGGCGCGGACGAACTG CACCGCAGCA GGATGTTGTC 201 GCAAGAACTC AGCCGCCTGT ACGCGCAAACCGCCGCCGAA CTGCTGTGCA 251 GTCAAAACCT CGCGCCGTCC GACATTACCG CCCTCGGCTGCCACGGGCAA 301 ACCGTCAGAC ACGCGCCGGA ACACAGTTAC AGCGTACAGC TTGCCGATTT351 GCCGCTGCTG GCGGAACGGA CTCAGATTTT TACCGTCGGC GACTTCCGCA 401GCCGCGACCT TGCGGCCGGC GGACAAGGCG CGCCGCTCGT CCCCGCCTTT 451 CACGAAGCCCTGTTCCGCGA CGACAGGGAA ACACGCGCGG TACTGAACAT 501 CGGCGGGATT GCCAACATCAGCGTACTCCC CCCCGACGCA CCCGCCTTCG 551 GCTTCGACAC AGGACCGGGC AATATGCTGATGGACGCGTG GATGCAGGCA 601 CACTGGCAGC TTCCTTACGA CAAAAACGGT GCAAAGGCGGCACAAGGCAA 651 CATATTGCCG CAACTGCTCG ACAGGCTGCT CGCCCACCCG TATTTCGCAC701 AACCCCACCC TAAAAGCACG GGGCGCGAAC TGTTTGCCCT AAATTGGCTC 751GAAACCTACC TTGACGGCGG CGAAAACCGA TACGACGTAT TGCGGACGCT 801 TTCCCGATTCACCGCGCAAA CCGTTTTCGA CGCCGTCTCA CACGCAGCGG 851 CAGATGCCCG TCAAATGTACATTTGCGGCG GCGGCATCCG CAATCCTGTT 901 TTAATGGCGG ATTTGGCAGA ATGTTTCGGCACACGCGTTT CCCTGCACAG 951 CACCGCCGAA CTGAACCTCG ATCCGCAATG GGTAGAAGCCGCCGCGTTCG 1001 CATGGATGGC GGCGTGTTGG GTCAACCGCA TTCCCGGTAG TCCGCACAAA1051 GCAACCGGCG CATCCAAACC GTGTATTCTG GGCGCGGGAT ATTATTATTG 1101 AThis corresponds to the amino acid sequence <SEQ ID 444; ORF 121-1.a>:

a121-1.pep 1 METQLYIGIM SGTSMDGADA VLIRMDGGKW LGAEGHAFTP YPGRLRRKLL 51DLQDTGADEL HRSRMLSQEL SRLYAQTAAE LLCSQNLAPS DITALGCHGQ 101 TVRHAPEHSYSVQLADLPLL AERTQIFTVG DFRSRDLAAG GQGAPLVPAF 151 HEALFRDDRE TRAVLNIGGIANISVLPPDA PAFGFDTGPG NMLMDAWMQA 201 HWQLPYDKNG AKAAQGNILP QLLDRLLAHPYFAQPHPKST GRELFALNWL 251 ETYLDGGENR YDVLRTLSRF TAQTVFDAVS HAAADARQMYICGGGIRNPV 301 LMADLAECFG TRVSLHSTAE LNLDPQWVEA AAFAWMAACW VNRIPGSPHK351 ATGASKPCIL GAGYYY* m121-1/a121-1 96.4% identity in 366 aa overlap        10        20        30        40        50        60 m121-1.pepMETQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRQLLDLQDTGADEL|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||| a121-1METQLYIGIMSGTSMDGADAVLIRMDGGKWLGAEGHAFTPYPGRLRRKLLDLQDTGADEL        10        20        30        40        50        60        70        80        90       100       110       120 m121-1.pepHRSRILSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHGYSIQLADLPLL||||:|||||||||||||||||||||||||||||||||||||||||||:||:|||||||| a121-1HRSRMLSQELSRLYAQTAAELLCSQNLAPSDITALGCHGQTVRHAPEHSYSVQLADLPLL        70        80        90       100       110       120       130       140       150       160       170       180 m121-1.pepAERTRIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDNRETRAVLNIGGIANISVLPPDA||||:||||||||||||||||||||||||||||||||:|||||||||||||||||||||| a121-1AERTQIFTVGDFRSRDLAAGGQGAPLVPAFHEALFRDDRETRAVLNIGGIANISVLPPDA       130       140       150       160       170       180       190       200       210       220       230       240 m121-1.pepPAFGFDTGPGNMLMDAWTQAHWQLPYDKNGAKAAQGNILPQLLDRLLAHPYFAQPHPKST||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||| a121-1PAFGFDTGPGNMLMDAWMQAHWQLPYDKNGAKAAQGNILPQLLDRLLAHPYFAQPHPKST       190       200       210       220       230       240       250       260       270       280       290       300 m121-1.pepGRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVCDAVSHAAADARQMYICGGGIRNPV||||||||||||||||||||||||||||||||||| |||||||||||||||||||||||| a121-1GRELFALNWLETYLDGGENRYDVLRTLSRFTAQTVFDAVSHAAADARQMYICGGGIRNPV       250       260       270       280       290       300       310       320       330       340       350       360 m121-1.pepLMADLAECFGTRVSLHSTADLNLDPQWVEAAXFAWLAACWINRIPGSPHKATGASKPCIL|||||||||||||||||||:||||||||||| |||:||||:||||||||||||||||||| a121LMADLAECFGTRVSLHSTAELNLDPQWVEAAAFAWMAACWVNRIPGSPHKATGASKPCIL       310       320       330       340       350       360 m121-1.pepXAGYYYX  |||||| a121 GAGYYYXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 445>:

g122.seq 1 ATGGCTTTAC TGAGCATCCG CAAGCTGCAC AAACAATACG GCAGCGTAAC 51CGCCATCCAA TCCTTAGACT TGGACTTGGA AAAAGGCGAA GtcatCGTAC 101 TGCTGGGCCCgTccggctgc ggCAAATCCA CCCTcctgcg ctgcgtcaaC 151 GGTTTGGAGC CGCACCAaggcgGCAGCATC GTGATGGACG GTgtcgGCGA 201 ATTCggcAAA GACGTTTCCT GGCAAACCGCCCGGCAAAAa gtcggtatgg 251 tctttcaaag taacgAactg Tttgcccaca tgaccgtcatcgAaaacatc 301 ttcttAggcC CGGTAAagga aCAAAAcCgc gaccgtgccg aagcaGAGGC351 gCAAGCCGGC AAactGttgg aacgcgTCGG actgctAGAC CGCAAAAACG 401CCTATCCGCG CGAACTTTCC GGCGGTCAGA AACAGCGCAT CGCCATTGTC 451 CGCGCCCTGTGCCTGAATCC GGAAGTCATC CTGCTGGACG AAATCACCGC 501 CGCACTTGAC CCCGAAATGGTGCGCGAAGT CTTGGAAGTG GTTTTGGAAC 551 TCGCCCGCGA AGGGATGAGT ATGCTCATCGTAACCCACGA AATGGGGTTC 601 GCACGCAAAG TTGCCGACCG CATCGTCTTT ATGGACAAAGGCGGCATCGT 651 CGAATCGTCC GACCCCGAAA CCTTTTTTTC CGCACCAAAA AGCGAACGCG701 CCCGCCAATT TCTGGCAGGT ATGGACTACT GAThis corresponds to the amino acid sequence <SEQ ID 446; ORF 122.ng>:

g122.pep 1 MALLSIRKLH KQYGSVTAIQ SLDLDLEKGE VIVLLGPSGC GKSTLLRCVN 51GLEPHQGGSI VMDGVGEFGK DVSWQTARQK VGMVFQSNEL FAHMTVIENI 101 FLGPVKEQNRDRAEAEAQAG KLLERVGLLD RKNAYPRELS GGQKQRIAIV 151 RALCLNPEVI LLDEITAALDPEMVREVLEV VLELAREGMS MLIVTHEMGF 201 ARKVADRIVF MDKGGIVESS DPETFFSAPKSERARQFLAG MDY*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 447>:

m122.seq 1 GTTGTCATGA TTAAAATCCG CAATATCCAT AAGACCTTTG GCGAAAACAC 51TATTTTGCGC GGCATCGATT TGGATGTGTG CAAAGGGCAG GTGGTCGTCA 101 TCCTCGGGcCTTCCGGCTCA GGCAAAACGA CGTTTCTGCG ATGCCTAAAC 151 GCGTTGGAAA TGCCCGAAGACGGACAAATC GAGTTCGACA ACGAGCGACC 201 GCTGAAAATC GATTTTTCTA AAAAACCAAGCAAACACGAT ATTTTGGCAC 251 TGCGCCGCAA ATCAkGCATG GTGTTTCAAC AATACAAyCTCTTTCCGCAC 301 AAAACCGCCT TGGAAAACGT AATGGAAGGA CCGGTTGCCG TACAgGGCAA351 GCCTGCCGCC CAAGCGCGCG AAGAGGCTCT GAAACTGCTG GAAAAAGTCG 401GCTTGGGCGA CAAAGTGGAT TTGTATCCCT ACCAGCTTTC CGGCGGTCAG 451 CAGCAGCGCGTCGGCATTGC CCGCGCATTG GCGATTCAGC CTGAACTGAT 501 GCTGTTTGAC GAACCGACTTCCGCGCTCGA TCCTGAATTG GTGCAAGATG 551 TTTTGGATmC CATGAAGGAA TTGGCGCAAGAAGGCTGGAC CATGGTTGTC 601 GTTACGCATG AAATCAAGTT CGCCTTAGAA GTGGCAACCACCGwCGTCGT 651 GATGGACrGC GGCGTTATTG TCGAACAAGG CAGCCCGCAA GATTTGTTCG701 ACCACCCCAA ACACGAACGG ACGCGGAGAT TTTTAAGCCA AATCCAATCT 751ACCAAGATTT GAThis corresponds to the amino acid sequence <SEQ ID 448; ORF 122>:

m122.pep 1 VVMIKIRNIH KTFGENTILR GIDLDVCKGQ VVVILGPSGS GKTTFLRCLN 51ALEMPEDGQI EFDNERPLKI DFSKKPSKHD ILALRRKSXM VFQQYNLFPH 101 KTALENVMEGPVAVQGKPAA QAREEALKLL EKVGLGDKVD LYPYQLSGGQ 151 QQRVGIARAL AIQPELMLFDEPTSALDPEL VQDVLDXMKE LAQEGWTMVV 201 VTHEIKFALE VATTXVVMDX GVIVEQGSPQDLFDHPKHER TRRFLSQIQS 251 TKI*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 122 shows 47.2% identity over a 246 aa overlap with a predicted ORF(ORF 122.ng) from N. gonorrhoeae:

m122/g122         10        20        30        40        50        60m122.pep VVMIKIRNIHKTFGENTILRGIDLDVCKGQVVVILGPSGSGKTTFLRCLNALEMPEDGQI:::::||::|| :|  | ::::|||: ||:|:|:||||| ||:|:|||:|:||  : |:| g122MALLSIRKLHKQYGSVTAIQSLDLDLEKGEVIVLLGPSGCGKSTLLRCVNGLEPHQGGSI        10        20        30        40        50        60        70        80        90       100       110       120 m122.pepEFDNERPLKIDFSKKPSKHDILALRRKSXMVFQQYNLFPHKTALENVMEGPVAVQGKPAA :|:   :  | | : :       |:|  ||||: :|| | |::||:: |||  |::  | g122VMDGVGEFGKDVSWQTA-------RQKVGMVFQSNELFAHMTVIENIFLGPVKEQNRDRA        70               80        90       100       110       130       140       150       160       170       180 m122.pepQAREEALKLLEKVGLGDKVDLYPYQLSGGQQQRVGIARALAIQPELMLFDEPTSALDPEL :|::| ||||:||| |: : || :|||||:||::|:||| ::||::|:|| |:|||||: g122EAEAQAGKLLERVGLLDRKNAYPRELSGGQKQRIAIVRALCLNPEVILLDEITAALDPEM    120       130       140       150       160       170       190       200       210       220       230       240 m122.pepVQDVLDXMKELAQEGWTMVVVTHEIKFALEVATTXVVMDXGVIVEQGSPQDLFDHPKHER |::||: :|||:|| :|::||||: || :||   | || | |||:::|: :|: || || g122VREVLEVVLELAREGMSMLIVTHEMGFARKVADRIVFMDKGGIVESSDPETFFSAPKSER    180       190       200       210       220       230        250m122.pep TRRFLSQIQSTKIX :|:||: g122 ARQFLAGMDYX     240The following partial DNA sequence was identified in N. meningitidis<SEQ ID 449>:

a122.seq 1 GTTGTCATGA TTAAAATCCG CAATATCCAT AAGACCTTCG GCAAAAATAC 51CATTTTGCGC GGCATCAATT TGGATGTGTG CAAAGGGCAG GTGGTCGTCA 101 TCCTCGGGCCTTCCGGCTCA GGCAAAACGA CGTTTCTGCG ATGCCTAAAC 151 GCGTTGGAAA TGCCCGAAGACGGACAAATC GAGTTCGACA ACGAGCGACC 201 GCTGAAAATC GATTTTTCTA AAAAACCAAGCAAACACGAT ATTTTGGCAC 251 TGCGCCGCAA ATCAGGCATG GTGTTTCAAC AATACAACCTCTTTCCGCAC 301 AAAACCGCCT TGGAAAACGT GATGGAAGGA CCGGTTGCCG TACAGGGCAA351 GCCTGCCGCC CAAGCGCGCG AAGAGGCTCT GAAACTGCTG GAAAAAGTCG 401GCTTGGGCGA CAAAGTGGAT TTGTATCCCT ACCAGCTTTC CGGCGGTCAG 451 CAGCAGCGCGTCGGCATTGC CCGAGCATTG GCGATTCAGC CCGAGCTGAT 501 GTTGTTTGAC GAACCCACTTCCGCGCTTGA CCCCGAGTTG GTGCAAGACG 551 TGTTGAACGC CATGAAGGAA TTGGCGCGGGAAGGTTGGAC GATGGTCGTC 601 GTTACCCACG AAATCAAGTT CGCGCTGGAA GTTGCCACGACCGTTGTCGT 651 GATGGACGGC GGCGTTATCG TAGAGCAGGG CAGCCCGAAA GAGTTGTTCG701 ACCACCCCAA ACACGAACGG ACGCGGAGAT TTTTAAGCCA AATCCAATCT 751ACCAAGATTT GAThis corresponds to the amino acid sequence <SEQ ID 450; ORF 122.a>:

a122.pep 1 VVMIKIRNIH KTFGKNTILR GINLDVCKGQ VVVILGPSGS GKTTFLRCLN 51ALEMPEDGQI EFDNERPLKI DFSKKPSKHD ILALRRKSGM VFQQYNLFPH 101 KTALENVMEGPVAVQGKPAA QAREEALKLL EKVGLGDKVD LYPYQLSGGQ 151 QQRVGIARAL AIQPELMLFDEPTSALDPEL VQDVLNAMKE LAREGWTMVV 201 VTHEIKFALE VATTVVVMDG GVIVEQGSPKELFDHPKHER TRRFLSQIQS 251 TKI* m122/a122 96.0% identity in 253 aaoverlap         10        20        30        40        50        60m122.pep VVMIKIRNIHKTFGENTILRGIDLDVCKGQVVVILGPSGSGKTTFLRCLNALEMPEDGQI||||||||||||||:|||||||:||||||||||||||||||||||||||||||||||||| a122VVMIKIRNIHKTFGKNTILRGINLDVCKGQVVVILGPSGSGKTTFLRCLNALEMPEDGQI        10        20        30        40        50        60        70        80        90       100       110       120 m122.pepEFDNERPLKIDFSKKPSKHDILALRRKSXMVFQQYNLFPHKTALENVMEGPVAVQGKPAA|||||||||||||||||||||||||||| ||||||||||||||||||||||||||||||| a122EFDNERPLKIDFSKKPSKHDILALRRKSGMVFQQYNLFPHKTALENVMEGPVAVQGKPAA        70        80        90       100       110       120       130       140       150       160       170       180 m122.pepQAREEALKLLEKVGLGDKVDLYPYQLSGGQQQRVGIARALAIQPELMLFDEPTSALDPEL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a122QAREEALKLLEKVGLGDKVDLYPYQLSGGQQQRVGIARALAIQPELMLFDEPTSALDPEL       130       140       150       160       170       180       190       200       210       220       230       240 m122.pepVQDVLDXMKELAQEGWTMVVVTHEIKFALEVATTXVVMDXGVIVEQGSPQDLFDHPKHER |||||:|||||:||||||||||||||||||||| |||| |||||||||::||||||||| a122VQDVLNAMKELAREGWTMVVVTHEIKFALEVATTVVVMDGGVIVEQGSPKELFDHPKHER       190       200       210       220       230       240        250m122.pep TRRFLSQIQSTKIX |||||||||||||| a122 TRRFLSQIQSTKIX        250The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 451>:

g122-1.seq 1 ATGATTAAAA TCCGCAATAT CCATAAGACC TTTGGCGAAA ACACCATTTT 51GCGCGGCATC GATTTGGATG TGGGCAAAGG GCAGGTGGTC GTCATCCTCG 101 GGCCTTCCGGCTCGGGTAAA ACAACATTTC TGCGCTGCCT AAACGCGTTG 151 GAAATGCCCG AAGACGGACAAATCGAGTTC GACAACGCGC GGCCGTTACG 201 CATTGATTTT TCCAAAAAAA CAAGCAAACACGATATTTTG GCACTGCGCC 251 GCAAGTCCGG AATGGTATTC CAACAATACA ACCTCTTCCCGCATAAAACC 301 GTGTTGGAAA ACGTGATGGA AGGGCCGGTT GCCGTACAGG GCAAGCCTGC351 CGCCCAAGCG CGCGAAGAGG CTTTGAAACT GCTGGAAAAA GTCGGCTTGG 401GCGATAAAGT GGATTTGTAT CCCTACCAGC TTTCCGGCGG TCAGCAGCAG 451 CGTGTCGGTATCGCCCGCGC ACTGGCGATT CAGCCTGAAT TGATGCTGTT 501 TGACGAACCC ACTTCCGCGCTGGACCCCGA GTTGGTGCAA GACGTGTTGG 551 ACGCCATGAA GGAATTGGCG CGGGAAGGTTGGACGATGGT CGTCGTTACC 601 CACGAAATCA AGTTCACGCT GGAAGTTGCC ACGAACGTCGTCGTGATGGA 651 CGGCGGCGTT ATCGTAGAGC AGGGCAGCCC GAAAGAGTTG TTCGACCACC701 TCAAACACGA ACGGACGCGG AGATTTTTAA GCCAAATCCA ATCTGCCAAG 751 ATTTGAThis corresponds to the amino acid sequence <SEQ ID 452; ORF 122-1.ng>:

g122-1.pep 1 MIKIRNIHKT FGENTILRGI DLDVGKGQVV VILGPSGSGK TTFLRCLNAL 51EMPEDGQIEF DNARPLRIDF SKKTSKHDIL ALRRKSGMVF QQYNLFPHKT 101 VLENVMEGPVAVQGKPAAQA REEALKLLEK VGLGDKVDLY PYQLSGGQQQ 151 RVGIARALAI QPELMLFDEPTSALDPELVQ DVLDAMKELA REGWTMVVVT 201 HEIKFTLEVA TNVVVMDGGV IVEQGSPKELFDHLKHERTR RFLSQIQSAK 251 I*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 453>:

m122-1.seq 1 ATGATTAAAA TCCGCAATAT CCATAAGACC TTTGGCGAAA ACACTATTTT 51GCGCGGCATC GATTTGGATG TGTGCAAAGG GCAGGTGGTC GTCATCCTCG 101 GGCCTTCCGGCTCAGGCAAA ACGACGTTTC TGCGATGCCT AAACGCGTTG 151 GAAATGCCCG AAGACGGACAAATCGAGTTC GACAACGAGC GACCGCTGAA 201 AATCGATTTT TCTAAAAAAC CAAGCAAACACGATATTTTG GCACTGCGCC 251 GCAAATCAGG CATGGTGTTT CAACAATACA ACCTCTTTCCGCACAAAACC 301 GCCTTGGAAA ACGTAATGGA AGGACCGGTT GCCGTACAGG GCAAGCCTGC351 CGCCCAAGCG CGCGAAGAGG CTCTGAAACT GCTGGAAAAA GTCGGCTTGG 401GCGACAAAGT GGATTTGTAT CCCTACCAGC TTTCCGGCGG TCAGCAGCAG 451 CGCGTCGGCATTGCCCGCGC ATTGGCGATT CAGCCTGAAC TGATGCTGTT 501 TGACGAACCG ACTTCCGCGCTCGATCCTGA ATTGGTGCAA GATGTTTTGG 551 ATACCATGAA GGAATTGGCG CAAGAAGGCTGGACCATGGT TGTCGTTACG 601 CATGAAATCA AGTTCGCCTT AGAAGTGGCA ACCACCGTCGTCGTGATGGA 651 CGGCGGCGTT ATTGTCGAAC AAGGCAGCCC GCAAGATTTG TTCGACCACC701 CCAAACACGA ACGGACGCGG AGATTTTTAA GCCAAATCCA ATCTACCAAG 751 ATTTGAThis corresponds to the amino acid sequence <SEQ ID 454; ORF 122-1>:

m122-1.pep 1 MIKIRNIHKT FGENTILRGI DLDVCKGQVV VILGPSGSGK TTFLRCLNAL 51EMPEDGQIEF DNERPLKIDF SKKPSKHDIL ALRRKSGMVF QQYNLFPHKT 101 ALENVMEGPVAVQGKPAAQA REEALKLLEK VGLGDKVDLY PYQLSGGQQQ 151 RVGIARALAI QPELMLFDEPTSALDPELVQ DVLDTMKELA QEGWTMVVVT 201 HEIKFALEVA TTVVVMDGGV IVEQGSPQDLFDHPKHERTR RFLSQIQSTK 251 I* m122-1/g122-1 94.8% identity in 251 aaoverlap         10        20        30        40        50        60m122-1.pep MIKIRNIHKTFGENTILRGIDLDVCKGQVVVILGPSGSGKTTFLRCLNALEMPEDGQIEF|||||||||||||||||||||||| ||||||||||||||||||||||||||||||||||| g122-1MIKIRNIHKTFGENTILRGIDLDVGKGQVVVILGPSGSGKTTFLRCLNALEMPEDGQIEF        10        20        30        40        50        60        70        80        90       100       110       120 m122-1.pepDNERPLKIDFSKKPSKHDILALRRKSGMVFQQYNLFPHKTALENVMEGPVAVQGKPAAQA|| |||:|||||| ||||||||||||||||||||||||||:||||||||||||||||||| g122-1DNARPLRIDFSKKTSKHDILALRRKSGMVFQQYNLFPHKTVLENVMEGPVAVQGKPAAQA        70        80        90       100       110       120       130       140       150       160       170       180 m122-1.pepREEALKLLEKVGLGDKVDLYPYQLSGGQQQRVGIARALAIQPELMLFDEPTSALDPELVQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g122-1REEALKLLEKVGLGDKVDLYPYQLSGGQQQRVGIARALAIQPELMLFDEPTSALDPELVQ       130       140       150       160       170       180       190       200       210       220       230       240 m122-1.pepDVLDTMKELAQEGWTMVVVTHEIKFALEVATTVVVMDGGVIVEQGSPQDLFDHPKHERTR||||:|||||:||||||||||||||:|||||:|||||||||||||||::|||| |||||| g122-1DVLDAMKELAREGWTMVVVTHEIKFTLEVATNVVVMDGGVIVEQGSPKELFDHLKHERTR       190       200       210       220       230       240        250m122-1.pep RFLSQIQSTKIX ||||||||:||| g122-1 RFLSQIQSAKIX        250The following partial DNA sequence was identified in N. meningitidis<SEQ ID 455>:

a122-1.seq 1 ATGATTAAAA TCCGCAATAT CCATAAGACC TTCGGCAAAA ATACCATTTT 51GCGCGGCATC AATTTGGATG TGTGCAAAGG GCAGGTGGTC GTCATCCTCG 101 GGCCTTCCGGCTCAGGCAAA ACGACGTTTC TGCGATGCCT AAACGCGTTG 151 GAAATGCCCG AAGACGGACAAATCGAGTTC GACAACGAGC GACCGCTGAA 201 AATCGATTTT TCTAAAAAAC CAAGCAAACACGATATTTTG GCACTGCGCC 251 GCAAATCAGG CATGGTGTTT CAACAATACA ACCTCTTTCCGCACAAAACC 301 GCCTTGGAAA ACGTGATGGA AGGACCGGTT GCCGTACAGG GCAAGCCTGC351 CGCCCAAGCG CGCGAAGAGG CTCTGAAACT GCTGGAAAAA GTCGGCTTGG 401GCGACAAAGT GGATTTGTAT CCCTACCAGC TTTCCGGCGG TCAGCAGCAG 451 CGCGTCGGCATTGCCCGAGC ATTGGCGATT CAGCCCGAGC TGATGTTGTT 501 TGACGAACCC ACTTCCGCGCTTGACCCCGA GTTGGTGCAA GACGTGTTGA 551 ACGCCATGAA GGAATTGGCG CGGGAAGGTTGGACGATGGT CGTCGTTACC 601 CACGAAATCA AGTTCGCGCT GGAAGTTGCC ACGACCGTTGTCGTGATGGA 651 CGGCGGCGTT ATCGTAGAGC AGGGCAGCCC GAAAGAGTTG TTCGACCACC701 CCAAACACGA ACGGACGCGG AGATTTTTAA GCCAAATCCA ATCTACCAAG 751 ATTTGAThis corresponds to the amino acid sequence <SEQ ID 456; ORF 122-1.a>:

a122-1.pep 1 MIKIRNIHKT FGKNTILRGI NLDVCKGQVV VILGPSGSGK TTFLRCLNAL 51EMPEDGQIEF DNERPLKIDF SKKPSKHDIL ALRRKSGMVF QQYNLFPHKT 101 ALENVMEGPVAVQGKPAAQA REEALKLLEK VGLGDKVDLY PYQLSGGQQQ 151 RVGIARALAI QPELMLFDEPTSALDPELVQ DVLNAMKELA REGWTMVVVT 201 HEIKFALEVA TTVVVMDGGV IVEQGSPKELFDHPKHERTR RFLSQIQSTK 251 I* a122-1/m122-1 97.2% identity in 251 aaoverlap         10        20        30        40        50        60a122-1.pep MIKIRNIHKTFGKNTILRGINLDVCKGQVVVILGPSGSGKTTFLRCLNALEMPEDGQIEF||||||||||||:|||||||:||||||||||||||||||||||||||||||||||||||| m122-1MIKIRNIHKTFGENTILRGIDLDVCKGQVVVILGPSGSGKTTFLRCLNALEMPEDGQIEF        10        20        30        40        50        60        70        80        90       100       110       120 a122-1.pepDNERPLKIDFSKKPSKHDILALRRKSGMVFQQYNLFPHKTALENVMEGPVAVQGKPAAQA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m122-1DNERPLKIDFSKKPSKHDILALRRKSGMVFQQYNLFPHKTALENVMEGPVAVQGKPAAQA        70        80        90       100       110       120       130       140       150       160       170       180 a122-1.pepREEALKLLEKVGLGDKVDLYPYQLSGGQQQRVGIARALAIQPELMLFDEPTSALDPELVQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m122-1REEALKLLEKVGLGDKVDLYPYQLSGGQQQRVGIARALAIQPELMLFDEPTSALDPELVQ       130       140       150       160       170       180       190       200       210       220       230       240 a122-1.pepDVLNAMKELAREGWTMVVVTHEIKFALEVATTVVVMDGGVIVEQGSPKELFDHPKHERTR|||::|||||:||||||||||||||||||||||||||||||||||||::||||||||||| m122-1DVLDTMKELAQEGWTMVVVTHEIKFALEVATTVVVMDGGVIVEQGSPQDLFDHPKHERTR       190       200       210       220       230       240        250a122-1.pep RFLSQIQSTKIX |||||||||||| m122-1 RFLSQIQSTKIX        250The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 457>:

g125.seq 1 ATGTCGGGCA ATGCCTCCTC TCCTTCATCT TCCGCCGCCA TCGGGCTGGT 51TTGGTTCGGC GCGGCGGTAT CGATTGCCGA AATCAGCACG GGTACGCTGC 101 TCGCCCCCTTGGGCTGGCAG CGCGGTCTGG CGGCCCTGCT TTTGGGTCAT 151 GCCGTCGGCG GCGCGCTGTTTTTTGCGGCG GCGTATATCG GCGCACTGAC 201 CGGACGCAGC TCGATGGAAA GTGTGCGCCTGTCGTTCGGC AAATGCGGTT 251 CAGTGCTGTT TTCCGTGGCG AATATGCTGC AACTGGCCGGCTGGACGGCG 301 GTGATGATTT ACGTCGGCGC AacggTCAGC TCCGCTTTGG GCAAAGTGTT351 GTGGGACggc gaATCCTTTG TCTGGTGGGC ATTGGCAAAC GGCGCACTGA 401TCGTGCTGTG GCTGGTTTTC GGCGCACGCA GAACGGGCGG GCTGAAAACC 451 GTTTCGATGCTGCTGATGCT GCTTGCCGTG TTGTGGTTGA GCGTCGAAGT 501 GTTCGCTTCG TCCGGCACAAACGCCGCGCC CGCCGTTTCA GACGGCATGA 551 CCTTCGGAAC GGCAGTCGAA CTGTCCGCCGTCATGCCGCT TTCCTGGCTG 601 CCGCTGGCCG CCGACTACAC GCGCCAAGCA CGCCGCCCGTTTGCGGCAAC 651 CCTGACGGCA ACGCTCGCCT ATACGCTGAC GGGCTGCTGG ATGTATGCCT701 TGGGTTTGGC GGCGGCTCTG TTTACCGGAG AAACCGACGT GGCGAAAATC 751CTGTTGGGCG CGGGCTTGGG CATAACGGGC ATTCTGGCAG TCGTCCTCTC 801 CACCGTTACCACAACGTTTC TCGATACCTA TTCCGCCGGC GCGAGTGCGA 851 ACAACATTTC CGCGCGTTTTGCGGAAATAC CCGTCGCTGT CGGCGTTACC 901 CTGatccgca ccgtgcttgc cgtcatgctgcccgttaccg aatataaaaa 951 cttcctgctg cttatccgct cggtatttgg gccgatggcgggtggttttg 1001 attgccgaCT TTTttgtctt AAAACGGCGT GAThis corresponds to the amino acid sequence <SEQ ID 458; ORF 125.ng>:The following partial DNA sequence was identified in N. meningitidis<SEQ ID 459>:

m125.seq 1 ATGTCGGGCA ATGCCTCCTC TCCTTCATCT TCCTCCGCCA TCGGGCTGAT 51TTGGTTCGGC GCGGCGGTAT CGATTGCCGA AATCAGCACG GGTACGCTGC 101 TTGCGCCTTTGGGCTGGCAG CGCGGTCTGG CGGCTCTACT TTTGGGTCAT 151 GCCGTCGGCG GCGCGCTGTTTTTTGCGGCG GCGTATATCG GCGCACTGAC 201 CGGACGCAGC TCGATGGAAA GCGTGCGCCTGTCGTTCGGC AAACGCGGTT 251 CAGTGCTGTT TTCCGTGGCG AATATGCTGC AACTGGCCGGCTGGACGGCG 301 GTGATGATTT ACGCCGGCGC AACGGTCAGC TCCGCTTTGG GCAAAGTGTT351 GTGGGACGGC GAATCTTTTG TCTGGTGGGC ATTGGCAAAC GGCGCGCTGA 401TTGTGCTGTG GCTGGTTTTC GGCGCACGCA AAACAGGCGG GCTGAAAACC 451 GTTTCGATGCTGCTGATGCT GTTGGCGGTT CTGTGGCTGA GTGCCGAAGT 501 CTTTTCCACG GCAGGCAGCACCGCCGCACA GGTTTCAGAC GGCATGAGTT 551 TCGGAACGGC AGTCGAGCTG TCCGCCGTGATGCCGCTTTC CTGGCTGCCG 601 CTTGCCGCCG ACTACACGCG CCACGCGCGC CGCCCGTTTGCGGCAACCCT 651 GACGGCAACG CTCGCCTACA CGCTGACCGG CTGCTGGATG TATGCCTTGG701 GTTTGGCAGC GGCGTTGTTC ACCGGAGAAA CCGACGTGGC AAAAATCCTG 751CTGGGCGCAr GTTTGgGTGC GGCAGGCATT TTGGCGGTCG TCCTCTCCAC 801 CGTTACCACAACGTTTCTCG ATGCCTATTC CGCCGGCGCG AGTGCGAACA 851 ACATTTCCGC GCGTTTTGCGGAAACACCCG TCGCTGTCrG CGTTACCCTG 901 ATCGGCACGG TACTTGCCGT CATGCTGCCCGTTACCGAAT ATGAAAACTT 951 CCTGCTGCTT ATCGGCTCGG TATTTGCGCC GATGGCGGgCGGTTTTGATT 1001 GCCGACTTTT TCGTCTTGAA ACGGCGTGAThis corresponds to the amino acid sequence <SEQ ID 460; ORF 125>:

m125.pep 1 MSGNASSPSS SSAIGLIWFG AAVSIAEIST GTLLAPLGWQ RGLAALLLGH 51AVGGALFFAA AYIGALTGRS SMESVRLSFG KRGSVLFSVA NMLQLAGWTA 101 VMIYAGATVSSALGKVLWDG ESFVWWALAN GALIVLWLVF GARKTGGLKT 151 VSMLLMLLAV LWLSAEVFSTAGSTAAQVSD GMSFGTAVEL SAVMPLSWLP 201 LAADYTRHAR RPFAATLTAT LAYTLTGCWMYALGLAAALF TGETDVAKIL 251 LGAXLGAAGI LAVVLSTVTT TFLDAYSAGASANNISARFA ETPVAVXVTL 301 IGTVLAVMLP VTEYENFLLL IGSVFAPMAG GFDCRLFRLETA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 125 shows 92.1% identity over a 343 aa overlap with a predicted ORF(ORF 125.ng) from N. gonorrhoeae:

m125/g125           10        20        30        40        50        60m125.pep   MSGNASSPSSSSAIGLIWFGAAVSIAEISTGTLLAPLGWQRGLAALLLGHAVGGALFFAA  |||||||||||:||||:||||||||||||||||||||||||||||||||||||||||||| g125  MSGNASSPSSSAAIGLVWFGAAVSIAEISTGTLLAPLGWQRGLAALLLGHAVGGALFFAA          10        20        30        40        50        60          70        80        90       100       110       120 m125.pep  AYIGALTGRSSMESVRLSFGKRGSVLFSVANMLQLAGWTAVMIYAGATVSSALGKVLWDG  ||||||||||||||||||||| ||||||||||||||||||||||:||||||||||||||| g125  AYIGALTGRSSMESVRLSFGKCGSVLFSVANMLQLAGWTAVMIYVGATVSSALGKVLWDG          70        80        90       100       110       120         130       140       150       160       170       179 m125.pep  ESFVWWALANGALIVLWLVFGARKTGGLKTVSMLLMLLAVLWLSAEVFSTAGSTAAQ-VS  |||||||||||||||||||||||:||||||||||||||||||||:|||:::|::||  || g125  ESFVWWALANGALIVLWLVFGARRTGGLKTVSMLLMLLAVLWLSVEVFASSGTNAAPAVS         130       140       150       160       170       180180       190       200       210       220       230      239 m125.pep  DGMSFGTAVELSAVMPLSWLPLAADYTRHARRPFAATLTATLAYTLTGCWMYALGLAAAL  |||:||||||||||||||||||||||||:||||||||||||||||||||||||||||||| g125  DGMTFGTAVELSAVMPLSWLPLAADYTRQARRPFAATLTATLAYTLTGCWMYALGLAAAL         190       200       210       220       230       240240       250       260       270       280       290      299 m125.pep  FTGETDVAKILLGAXLGAAGILAVVLSTVTTTFLDAYSAGASANNISARFAETPVAVXVT  |||||||||||||| || :||||||||||||||||:|||||||||||||||| |||| || g125  FTGETDVAKILLGAGLGITGILAVVLSTVTTTFLDTYSAGASANNISARFAEIPVAVGVT         250       260       270       280       290       300300       310       320       330       340 m125.pep  LIGTVLAVMLPVTEYENFLLLIGSVFAPMAGGFDCRLFRLETAX  || ||||||||||||:|||||| |||:||||||||||| |:||| g125  LIRTVLAVMLPVTEYKNFLLLIRSVFGPMAGGFDCRLFCLKTAX         310       320       330       340The following partial DNA sequence was identified in N. meningitidis<SEQ ID 461>:

a125.seq 1 ATGTCGGGCA ATGCCTCCTC TCCTTCATCT TCCGCCGCCA TCGGGCTGAT 51TTGGTTCGGC GCGGCGGTAT CGATTGCCGA AATCAGCACG GGTACACTGC 101 TTGCGCCTTTGGGCTGGCAG CGCGGTCTGG CGGCTCTGCT TTTGGGTCAT 151 GCCGTCGGCG GCGCGCTGTTTTTTGCGGCG GCGTATATCG GCGCACTGAC 201 CGGACGCAGC TCGATGGAAA GCGTGCGCCTGTCGTTCGGC AAACGCGGTT 251 CAGTGCTGTT TTCCGTGGCG AATATGCTGC AACTGGCCGGCTGGACGGCG 301 GTGATGATTT ACGCCGGCGC AACGGTCAGC TCCGCTTTGG GCAAAGTGTT351 GTGGGACGGC GAATCTTTTG TCTGGTGGGC ATTGGCAAAC GGCGCGCTGA 401TTGTGCTGTG GCTGGTTTTC GGCGCACGCA AAACAGGCGG GCTGAAAACC 451 GTTTCGATGCTGCTGATGCT GTTGGCGGTT CTGTGGCTGA GTGCCGAAGT 501 CTTTTCCACG GCAGGCAGCACCGCCGCACA GGTTTCAGAC GGCATGAGTT 551 TCGGAACGGC AGTCGAGCTG TCCGCCGTGATGCCGCTTTC TTGGCTGCCG 601 CTGGCCGCCG ACTACACGCG CCACGCGCGC CGCCCGTTTGCGGCAACCCT 651 GACGGCAACG CTCGCCTACA CGCTGACCGG CTGCTGGATG TATGCCTTGG701 GTTTGGCAGC GGCGTTGTTC ACCGGAGAAA CCGACGTGGC AAAAATCCTG 751CTGGGCGCAG GTTTGGGTGC GGCAGGCATT TTGGCGGTCG TCCTGTCGAC 801 CGTTACCACCACTTTTCTCG ATGCCTACTC CGCCGGCGTA AGTGCCAACA 851 ATATTTCCGC CAAACTTTCGGAAATACCCA TCGCCGTTGC CGTCGCCGTT 901 GTCGGCACAC TGCTTGCCGT CCTCCTGCCCGTTACCGAAT ATGAAAACTT 951 CCTGCTGCTT ATCGGCTCGG TATTTGCGCC GATGGCG.GCGGTTTTGATT 1001 GCCGACTTTT TCGTCTTGAA ACGGCGTGAThis corresponds to the amino acid sequence <SEQ ID 462; ORF 125.a>:

a125.pep 1 MSGNASSPSS SAAIGLIWFG AAVSIAEIST GTLLAPLGWQ RGLAALLLGH 51AVGGALFFAA AYIGALTGRS SMESVRLSFG KRGSVLFSVA NMLQLAGWTA 101 VMIYAGATVSSALGKVLWDG ESFVWWALAN GALIVLWLVF GARKTGGLKT 151 VSMLLMLLAV LWLSAEVFSTAGSTAAQVSD GMSFGTAVEL SAVMPLSWLP 201 LAADYTRHAR RPFAATLTAT LAYTLTGCWMYALGLAAALF TGETDVAKIL 251 LGAGLGAAGI LAVVLSTVTT TFLDAYSAGV SANNISAKLSEIPIAVAVAV 301 VGTLLAVLLP VTEYENFLLL IGSVFAPMAX GFDCRLFRLE TA* m125/a12595.6% identity in 342 aa overlap        10        20        30        40        50        60 m125.pepMSGNASSPSSSSAIGLIWFGAAVSIAEISTGTLLAPLGWQRGLAALLLGHAVGGALFFAA|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||| a125MSGNASSPSSSAAIGLIWFGAAVSIAEISTGTLLAPLGWQRGLAALLLGHAVGGALFFAA        10        20        30        40        50        60        70        80        90       100       110       120 m125.pepAYIGALTGRSSMESVRLSFGKRGSVLFSVANMLQLAGWTAVMIYAGATVSSALGKVLWDG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a125AYIGALTGRSSMESVRLSFGKRGSVLFSVANMLQLAGWTAVMIYAGATVSSALGKVLWDG        70        80        90       100       110       120       130       140       150       160       170       180 m125.pepESFVWWALANGALIVLWLVFGARKTGGLKTVSMLLMLLAVLWLSAEVFSTAGSTAAQVSD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a125ESFVWWALANGALIVLWLVFGARKTGGLKTVSMLLMLLAVLWLSAEVFSTAGSTAAQVSD       130       140       150       160       170       180       190       200       210       220       230       240 m125.pepGMSFGTAVELSAVMPLSWLPLAADYTRHARRPFAATLTATLAYTLTGCWMYALGLAAALF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a125GMSFGTAVELSAVMPLSWLPLAADYTRHARRPFAATLTATLAYTLTGCWMYALGLAAALF       190       200       210       220       230       240       250       260       270       280       290       300 m125.pepTGETDVAKILLGAXLGAAGILAVVLSTVTTTFLDAYSAGASANNISARFAETPVAVXVTL||||||||||||| |||||||||||||||||||||||||:|||||||:::| |:|| |:: a125TGETDVAKILLGAGLGAAGILAVVLSTVTTTFLDAYSAGVSANNISAKLSEIPIAVAVAV       250       260       270       280       290       300       310       320       330       340 m125.pepIGTVLAVMLPVTEYENFLLLIGSVFAPMAGGFDCRLFRLETAX:||:|||:||||||||||||||||||||| ||||||||||||| a125VGTLLAVLLPVTEYENFLLLIGSVFAPMAXGFDCRLFRLETAX       310       320       330       340The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 463>:

g126.seq 1 AtgccgtcTG AAaccCcaaa ggcACGCCGC CGGCTTTCAG ACGGCATCGC 51GTCCGACAAC CATACCAAAG AATCCATCAT GCTCACCctg tacggcGAAA 101 CTTTCCCTTCGCGGCTGCTg ctcggcacgG cggcctacCC GACCCCTGAA 151 ATCCTCAAAC AATCCGTCCGAACCGCCCGG CCCGCGATGA ttaccGTCTC 201 GCTGCGCCGC ACGGGATGCG GCGGCGAGGCGCACGGTCAG GGGTTTTGGT 251 CGCTGCTTCA AGAAACCGGC GTTCCCGTCC TGCCGAACACGGCAGGCTGC 301 CAAAGCGTGC AGGAAGCGGT AACGACGGCG CAAATGGCGC GCGAAGTGTT351 TGAAACCGAT TGGATAAAAT TGGAACTCAT CGGCGACGAC GACACCTTGC 401AGCCGGACGT GTTCCAACTC GTCGAAGCGG CGGAAATCCT GATTAAAGAC 451 GGCTTCAAAGTGCTGCCTTA TTGCACCGAA GACCTGATTG CCTGCCGCCG 501 CCTGCTCGAT GCGGGCTGTCAGGCGTTGAT GCCGTGGGCG GCTCCCATCG 551 GCACGGGTTT GGGGGCGGTT CACGCCTATGCGCTCAAAAT CCTGCGCGAA 601 CGCCTGCCCG ACACGCCGCT GATTATCGAC GCGGGCTTGGGTTTGCCTTC 651 CCAAGCGGCA CAAGTGATGG AATGGGGTTT TGACGGCGTA TTGTTAAACA701 CCGCCGTTTC CCGCAGCGGC GACCCCGTCA ACATGGCGCG CGCCTTCGCA 751CTCGCCGTCG AATCCGGACG GCTGGCATTT GAAGCCGGGC CGGTCGAAGC 801 GCGAACCAAAGCCCAAGCCA GCACGCCGAC AGTCGGACAA CCGTTTTGGC 851 ATTCGGCGGA ATATTGAThis corresponds to the amino acid sequence <SEQ ID 464; ORF 126.ng>:

g126.pep 1 MPSETPKARR RLSDGIASDN HTKESIMLTL YGETFPSRLL LGTAAYPTPE 51ILKQSVRTAR PAMITVSLRR TGCGGEAHGQ GFWSLLQETG VPVLPNTAGC 101 QSVQEAVTTAQMAREVFETD WIKLELIGDD DTLQPDVFQL VEAAEILIKD 151 GFKVLPYCTE DLIACRRLLDAGCQALMPWA APIGTGLGAV HAYALKILRE 201 RLPDTPLIID AGLGLPSQAA QVMEWGFDGVLLNTAVSRSG DPVNMARAFA 251 LAVESGRLAF EAGPVEARTK AQASTPTVGQ PFWHSAEY*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 465>:

m126.seq (partial) 1 ..CACTATACAA AGGAACCCAT TATGCTCACC CTATACGGCGAAACTTTCCC 51   CTCGCGGCTG CTGCTCGGCA CGGCTGCCTA CCCGACCCCC GAAATCCTCA101   AACAATCCAT CCAAACCGCC CAGCCTGCGA TGATTACCGT CTCGCTGCGC 151  CGCGCGGGAA GCGGCGGCGA GGCGCACGGT CAGGGGTTTT GGTCGCTGCT 201  TCAAGAAACC GGCGTTCCCG TCCTGCCGAA CACGGCAGGC TGCCAAAGCG 251  TGCAGGAAGC GGTAACGACG GCGCAAATGG CGCGCGAAGT GTTTGAAACC 301  GATTGGATAA AATTGGAACT CATCGGAGAT GACGACACCT TGCAGCCGGA 351  TGTGTTCCAG CTTGTCGAAG CGGCGGAAAT CCTGATTAAA GACGGCTTCA 401  AAGTGCTGCC TTATTGCACC GAAGACCTGA TTGCCTGCCG CCGCCTGCTC 451  GACGCGGGCT GTCAGGCGTT GATGCCGTGG GCGGCCCCGA TCGGCACGGG 501  TTTGGGCGCG GTTCACGCCT ACGCGTTGAA CGTCCTGCGC GAACGCCTGC 551  CCGACACGCC GCTGATTATC GACGCGGGCT TGGGTTTGCC CTCACAGGCG 601  GCACAAGTGA TGGAATGGGG CTTTGACGGC GTGCTTTTGA ATACTGCCGT 651  TTCCCGCAGC GGCGATCCGG TCAATATGGC ACGCGCCTTC GCACTCGCCG 701  TCGAATCCGG ACGGCTGGCA TTTGAAGCCG GACCGGTCGA AGCACGCGAC 751  AAAGCGCAAG CCAGCACGCC GACAGTCGGA CAACCGTTTT GGCATTCGGC 801  GGAATATTGAThis corresponds to the amino acid sequence <SEQ ID 466; ORF 126>:

m126.pep (partial) 1 ..HYTKEPIMLT LYGETFPSRL LLGTAAYPTP EILKQSIQTAQPAMITVSLR 51   RAGSGGEAHG QGFWSLLQET GVPVLPNTAG CQSVQEAVTT AQMAREVFET101   DWIKLELIGD DDTLQPDVFQ LVEAAEILIK DGFKVLPYCT EDLIACRRLL 151  DAGCQALMPW AAPIGTGLGA VHAYALNVLR ERLPDTPLII DAGLGLPSQA 201  AQVMEWGFDG VLLNTAVSRS GDPVNMARAF ALAVESGRLA FEAGPVEARD 251  KAQASTPTVG QPFWHSAEY*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 126 shows 95.9% identity over a 269 aa overlap with a predicted ORF(ORF 126.ng) from N. gonorrhoeae:

m126/g126                            10        20        30        40m126.pep                    HYTKEPIMLTLYGETFPSRLLLGTAAYPTPEILKQSIQTAQ                   ::||| ||||||||||||||||||||||||||||||::||: g126MPSETPKARRRLSDGIASDNHTKESIMLTLYGETFPSRLLLGTAAYPTPEILKQSVRTAR        10        20        30        40        50        60       50        60        70        80        90       100 m126.pepPAMITVSLRRAGSGGEAHGQGFWSLLQETGVPVLPNTAGCQSVQEAVTTAQMAREVFETD||||||||||:| ||||||||||||||||||||||||||||||||||||||||||||||| g126PAMITVSLRRTGCGGEAHGQGFWSLLQETGVPVLPNTAGCQSVQEAVTTAQMAREVFETD        70        80        90       100       110       120      110       120       130       140       150       160 m126.pepWIKLELIGDDDTLQPDVFQLVEAAEILIKDGFKVLPYCTEDLIACRRLLDAGCQALMPWA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g126WIKLELIGDDDTLQPDVFQLVEAAEILIKDGFKVLPYCTEDLIACRRLLDAGCQALMPWA       130       140       150       160       170       180      170       180       190       200       210       220 m126.pepAPIGTGLGAVHAYALNVLRERLPDTPLIIDAGLGLPSQAAQVMEWGFDGVLLNTAVSRSG|||||||||||||||::||||||||||||||||||||||||||||||||||||||||||| g126APIGTGLGAVHAYALKILRERLPDTPLIIDAGLGLPSQAAQVMEWGFDGVLLNTAVSRSG       190       200       210       220       230       240      230       240       250       260       270 m126.pepDPVNMARAFALAVESGRLAFEAGPVEARDKAQASTPTVGQPFWHSAEYX|||||||||||||||||||||||||||| |||||||||||||||||||| g126DPVNMARAFALAVESGRLAFEAGPVEARTKAQASTPTVGQPFWHSAEYX       250       260       270       280The following partial DNA sequence was identified in N. meningitidis<SEQ ID 467>:

a126.seq 1 TTGTTAATCC ACTATACAAA GGAACCCATT ATGCTCACCC TGTACAGCGA 51AACTTTCCCT TCGCGGCTGC TGCTCGGCAC AGCCGCCTAC CCGACCCCTG 101 AAATCCTCAAACAATCCGTC CGAACCGCCC GGCCCGCGAT GATTACCGTC 151 TCGCTGCGCC GCGCGGGATGCGGCGGCGAG GCGCACGGTC AGGGGTTTTG 201 GTCGCTGCTT CAAGAAACCG GCGTTCCCGTCCTGCCGAAC ACGGCAGGCT 251 GCCAAAGCGT GCAGGAAGCG GTAACGACGG CGCAAATGGCGCGCGAAGTG 301 TTTGAAACCG ATTGGATTAA ACTCGAACTC ATCGGCGACG ACGACACCTT351 GCAGCCGGAT GTGTTCCAAC TTGTCGAAGC GGCGGAAATC CTGATTAAAG 401ACGGCTTCAA AGTGCTGCCT TATTGCACCG AAGACCTGAT TGCCTGCCGC 451 CGCCTGCTCGACGCGGGCTG TCAGGCGTTG ATGCCGTGGG CGGCCCCGAT 501 CGGCACGGGT TTGGGCGCGGTTCACGCCTA CGCGTTGAAC GTCCTGCGCG 551 AACGCCTGCC CGACACGCCG CTGATTATCGACGCGGGCTT GGGTTTGCCC 601 TCACAGGCGG CACAAGTGAT GGAATGGGGC TTTGACGGCGTGCTTTTGAA 651 TACTGCCGTT TCCCGCAGCG GCGATCCGGT CAATATGGCA CGCGCCTTCG701 CACTCGCCGT CGAATCCGGA CGGCTGGCAT TTGAAGCCGG ACCGGTCGAA 751GCACGCGACA AAGCGCAAGC CAGCACGCCG ACAGTCGGAC AACCGTTTTG 801 GCATTCGGCGGAATATTGAThis corresponds to the amino acid sequence <SEQ ID 468; ORF 126.a>:

a126.pep 1 LLIHYTKEPI MLTLYSETFP SRLLLGTAAY PTPEILKQSV RTARPAMITV 51SLRRAGCGGE AHGQGFWSLL QETGVPVLPN TAGCQSVQEA VTTAQMAREV 101 FETDWIKLELIGDDDTLQPD VFQLVEAAEI LIKDGFKVLP YCTEDLIACR 151 RLLDAGCQAL MPWAAPIGTGLGAVHAYALN VLRERLPDTP LIIDAGLGLP 201 SQAAQVMEWG FDGVLLNTAV SRSGDPVNMARAFALAVESG RLAFEAGPVE 251 ARDKAQASTP TVGQPFWHSA EY* m126/a126 98.1%identity in 269 aa overlap           10        20        30        40        50 m126.pep   HYTKEPIMLTLYGETFPSRLLLGTAAYPTPEILKQSIQTAQPAMITVSLRRAGSGGE   ||||||||||||:|||||||||||||||||||||||::||:|||||||||||| ||| a126LLIHYTKEPIMLTLYSETFPSRLLLGTAAYPTPEILKQSVRTARPAMITVSLRRAGCGGE        10        20        30        40        50        60 60        70        80        90       100       110 m126.pepAHGQGFWSLLQETGVPVLPNTAGCQSVQEAVTTAQMAREVFETDWIKLELIGDDDTLQPD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a126AHGQGFWSLLQETGVPVLPNTAGCQSVQEAVTTAQMAREVFETDWIKLELIGDDDTLQPD        70        80        90       100       110       120120       130       140       150       160       170 m126.pepVFQLVEAAEILIKDGFKVLPYCTEDLIACRRLLDAGCQALMPWAAPIGTGLGAVHAYALN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a126VFQLVEAAEILIKDGFKVLPYCTEDLIACRRLLDAGCQALMPWAAPIGTGLGAVHAYALN       130       140       150       160       170       180180       190       200       210       220       230 m126.pepVLRERLPDTPLIIDAGLGLPSQAAQVMEWGFDGVLLNTAVSRSGDPVNMARAFALAVESG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a126VLRERLPDTPLIIDAGLGLPSQAAQVMEWGFDGVLLNTAVSRSGDPVNMARAFALAVESG       190       200       210       220       230       240240       250       260       270 m126.pepRLAFEAGPVEARDKAQASTPTVGQPFWHSAEYX ||||||||||||||||||||||||||||||||| al26RLAFEAGPVEARDKAQASTPTVGQPFWHSAEYX        250       260       270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 469>:

g126-1.seq 1 ATGCTCACCC TGTACGGCGA AACTTTCCCT TCGCGGCTGC TGCTCGGCAC 51GGCCGCCTAC CCGACCCCTG AAATCCTCAA ACAATCCGTC CGAACCGCCC 101 GGCCCGCGATGATTACCGTC TCGCTGCGCC GCACGGGATG CGGCGGCGAG 151 GCGCACGGTC AGGGGTTTTGGTCGCTGCTT CAAGAAACCG GCGTTCCCGT 201 CCTGCCGAAC ACGGCAGGCT GCCAAAGCGTGCAGGAAGCG GTAACGACGG 251 CGCAAATGGC GCGCGAAGTG TTTGAAACCG ATTGGATAAAATTGGAACTC 301 ATCGGCGACG ACGACACCTT GCAGCCGGAC GTGTTCCAAC TCGTCGAAGC351 GGCGGAAATC CTGATTAAAG ACGGCTTCAA AGTGCTGCCT TATTGCACCG 401AAGACCTGAT TGCCTGCCGC CGCCTGCTCG ATGCGGGCTG TCAGGCGTTG 451 ATGCCGTGGGCGGCTCCCAT CGGCACGGGT TTGGGGGCGG TTCACGCCTA 501 TGCGCTCAAA ATCCTGCGCGAACGCCTGCC CGACACGCCG CTGATTATCG 551 ACGCGGGCTT GGGTTTGCCT TCCCAAGCGGCACAAGTGAT GGAATGGGGT 601 TTTGACGGCG TATTGTTAAA CACCGCCGTT TCCCGCAGCGGCGACCCCGT 651 CAACATGGCG CGCGCCTTCG CACTCGCCGT CGAATCCGGA CGGCTGGCAT701 TTGAAGCCGG GCCGGTCGAA GCGCGAACCA AAGCCCAAGC CAGCACGCCG 751ACAGTCGGAC AACCGTTTTG GCATTCGGCG GAATATTGAThis corresponds to the amino acid sequence <SEQ ID 470; ORF 126-1.ng>:

g126-1.pep 1 MLTLYGETFP SRLLLGTAAY PTPEILKQSV RTARPAMITV SLRRTGCGGE 51AHGQGFWSLL QETGVPVLPN TAGCQSVQEA VTTAQMAREV FETDWIKLEL 101 IGDDDTLQPDVFQLVEAAEI LIKDGFKVLP YCTEDLIACR RLLDAGCQAL 151 MPWAAPIGTG LGAVHAYALKILRERLPDTP LIIDAGLGLP SQAAQVMEWG 201 FDGVLLNTAV SRSGDPVNMA RAFALAVESGRLAFEAGPVE ARTKAQASTP 251 TVGQPFWHSA EY*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 471>:

m126-1.seq 1 ATGCTCACCC TATACGGCGA AACTTTCCCC TCGCGGCTGC TGCTCGGCAC 51GGCTGCCTAC CCGACCCCCG AAATCCTCAA ACAATCCATC CAAACCGCCC 101 AGCCTGCGATGATTACCGTC TCGCTGCGCC GCGCGGGAAG CGGCGGCGAG 151 GCGCACGGTC AGGGGTTTTGGTCGCTGCTT CAAGAAACCG GCGTTCCCGT 201 CCTGCCGAAC ACGGCAGGCT GCCAAAGCGTGCAGGAAGCG GTAACGACGG 251 CGCAAATGGC GCGCGAAGTG TTTGAAACCG ATTGGATAAAATTGGAACTC 301 ATCGGAGATG ACGACACCTT GCAGCCGGAT GTGTTCCAGC TTGTCGAAGC351 GGCGGAAATC CTGATTAAAG ACGGCTTCAA AGTGCTGCCT TATTGCACCG 401AAGACCTGAT TGCCTGCCGC CGCCTGCTCG ACGCGGGCTG TCAGGCGTTG 451 ATGCCGTGGGCGGCCCCGAT CGGCACGGGT TTGGGCGCGG TTCACGCCTA 501 CGCGTTGAAC GTCCTGCGCGAACGCCTGCC CGACACGCCG CTGATTATCG 551 ACGCGGGCTT GGGTTTGCCC TCACAGGCGGCACAAGTGAT GGAATGGGGC 601 TTTGACGGCG TGCTTTTGAA TACTGCCGTT TCCCGCAGCGGCGATCCGGT 651 CAATATGGCA CGCGCCTTCG CACTCGCCGT CGAATCCGGA CGGCTGGCAT701 TTGAAGCCGG ACCGGTCGAA GCACGCGACA AAGCGCAAGC CAGCACGCCG 751ACAGTCGGAC AACCGTTTTG GCATTCGGCG GAATATTGAThis corresponds to the amino acid sequence <SEQ ID 5; ORF 126-1>:

m126-1.pep 1 MLTLYGETFP SRLLLGTAAY PTPEILKQSI QTAQPAMITV SLRRAGSGGE 51AHGQGFWSLL QETGVPVLPN TAGCQSVQEA VTTAQMAREV FETDWIKLEL 101 IGDDDTLQPDVFQLVEAAEI LIKDGFKVLP YCTEDLIACR RLLDAGCQAL 151 MPWAAPIGTG LGAVHAYALNVLRERLPDTP LIIDAGLGLP SQAAQVMEWG 201 FDGVLLNTAV SRSGDPVNMA RAFALAVESGRLAFEAGPVE ARDKAQASTP 251 TVGQPFWHSA EY* m126-1/g126-1 96.9% identity in262 aa overlap        10        20        30        40        50        60 m126-1.pepMLTLYGETFPSRLLLGTAAYPTPEILKQSIQTAQPAMITVSLRRAGSGGEAHGQGFWSLL|||||||||||||||||||||||||||||::||:||||||||||:| ||||||||||||| g126-1MLTLYGETFPSRLLLGTAAYPTPEILKQSVRTARPAMITVSLRRTGCGGEAHGQGFWSLL        10        20        30        40        50        60        70        80        90       100       110       120 m126-1.pepQETGVPVLPNTAGCQSVQEAVTTAQMAREVFELDWIKLELIGDDDTLQPDVFQLVEAAEI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g126-1QETGVPVLPNTAGCQSVQEAVTTAQMAREVFELDWIKLELIGDDDTLQPDVFQLVEAAEI        70        80        90       100       110       120       130       140       150       160       170       180 m126-1.pepLIKDGFKVLPYCLEDLIACRRLLDAGCQALMPWAAPIGTGLGAVHAYALNVLRERLPDTP|||||||||||||||||||||||||||||||||||||||||||||||||::||||||||| g126-1LIKDGFKVLPYCLEDLIACRRLLDAGCQALMPWAAPIGTGLGAVHAYALKILRERLPDTP       130       140       150       160       170       180       190       200       210       220       230       240 m126-1.pepLIIDAGLGLPSQAAQVMEWGFDGVLLNTAVSRSGDPVNMARAFALAVESGRLAFEAGPVE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g126-1LIIDAGLGLPSQAAQVMEWGFDGVLLNTAVSRSGDPVNMARAFALAVESGRLAFEAGPVE       190       200       210       220       230       240       250       260 m126-1.pep ARDKAQASTPTVGQPFWHSAEYX|| |||||||||||||||||||| g126-1 ARTKAQASTPTVGQPFWHSAEYX       250       260The following partial DNA sequence was identified in N. meningitidis<SEQ ID 473>:

a126-1.seq 1 ATGCTCACCC TGTACAGCGA AACTTTCCCT TCGCGGCTGC TGCTCGGCAC 51AGCCGCCTAC CCGACCCCTG AAATCCTCAA ACAATCCGTC CGAACCGCCC 101 GGCCCGCGATGATTACCGTC TCGCTGCGCC GCGCGGGATG CGGCGGCGAG 151 GCGCACGGTC AGGGGTTTTGGTCGCTGCTT CAAGAAACCG GCGTTCCCGT 201 CCTGCCGAAC ACGGCAGGCT GCCAAAGCGTGCAGGAAGCG GTAACGACGG 251 CGCAAATGGC GCGCGAAGTG TTTGAAACCG ATTGGATTAAACTCGAACTC 301 ATCGGCGACG ACGACACCTT GCAGCCGGAT GTGTTCCAAC TTGTCGAAGC351 GGCGGAAATC CTGATTAAAG ACGGCTTCAA AGTGCTGCCT TATTGCACCG 401AAGACCTGAT TGCCTGCCGC CGCCTGCTCG ACGCGGGCTG TCAGGCGTTG 451 ATGCCGTGGGCGGCCCCGAT CGGCACGGGT TTGGGCGCGG TTCACGCCTA 501 CGCGTTGAAC GTCCTGCGCGAACGCCTGCC CGACACGCCG CTGATTATCG 551 ACGCGGGCTT GGGTTTGCCC TCACAGGCGGCACAAGTGAT GGAATGGGGC 601 TTTGACGGCG TGCTTTTGAA TACTGCCGTT TCCCGCAGCGGCGATCCGGT 651 CAATATGGCA CGCGCCTTCG CACTCGCCGT CGAATCCGGA CGGCTGGCAT701 TTGAAGCCGG ACCGGTCGAA GCACGCGACA AAGCGCAAGC CAGCACGCCG 751ACAGTCGGAC AACCGTTTTG GCATTCGGCG GAATATTGAThis corresponds to the amino acid sequence <SEQ ID 474; ORF 126-1.a>:

a126-1.pep 1 MLTLYSETFP SRLLLGTAAY PTPEILKQSV RTARPAMITV SLRRAGCGGE 51AHGQGFWSLL QETGVPVLPN TAGCQSVQEA VTTAQMAREV FETDWIKLEL 101 IGDDDTLQPDVFQLVEAAEI LIKDGFKVLP YCTEDLIACR RLLDAGCQAL 151 MPWAAPIGTG LGAVHAYALNVLRERLPDTP LIIDAGLGLP SQAAQVMEWG 201 FDGVLLNTAV SRSGDPVNMA RAFALAVESGRLAFEAGPVE ARDKAQASTP 251 TVGQPFWHSA EY* a126-1/m126-1 98.1% identity in262 aa overlap        10        20        30        40        50        60 a126-1.pepMLTLYSETFPSRLLLGTAAYPTPEILKQSVRTARPAMITVSLRRAGCGGEAHGQGFWSLL|||||:|||||||||||||||||||||||::||:|||||||||||| ||||||||||||| m126-1MLTLYGETFPSRLLLGTAAYPTPEILKQSIQTAQPAMITVSLRRAGSGGEAHGQGFWSLL        10        20        30        40        50        60        70        80        90       100       110       120 a126-1.pepQETGVPVLPNTAGCQSVQEAVTTAQMAREVFELDWIKLELIGDDDTLQPDVFQLVEAAEI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m126-1QETGVPVLPNTAGCQSVQEAVTTAQMAREVFELDWIKLELIGDDDTLQPDVFQLVEAAEI        70        80        90       100       110       120       130       140       150       160       170       180 a126-1.pepLIKDGFKVLPYCLEDLIACRRLLDAGCQALMPWAAPIGTGLGAVHAYALNVLRERLPDTP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m126-1LIKDGFKVLPYCLEDLIACRRLLDAGCQALMPWAAPIGTGLGAVHAYALNVLRERLPDTP       130       140       150       160       170       180       190       200       210       220       230       240 a126-1.pepLIIDAGLGLPSQAAQVMEWGFDGVLLNTAVSRSGDPVNMARAFALAVESGRLAFEAGPVE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m126-1LIIDAGLGLPSQAAQVMEWGFDGVLLNTAVSRSGDPVNMARAFALAVESGRLAFEAGPVE       190       200       210       220       230       240       250       260 a126-1.pep ARDKAQASTPTVGQPFWHSAEYX||||||||||||||||||||||| m126-1 ARDKAQASTPTVGQPFWHSAEYX       250       260The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 475>:

g127.seq 1 ATGGAAATAT GGAATATGTT GAACACTTGG CCCGATGCCG TCCCGATACG 51CGCGGAGGCG GCCGAATCCG TGGCGGCGGT CGCGGCTTTG CTGCTGGCGC 101 GCGCCCTTCTGTTGAATATC CACTTCAGAC GGCATCCGGA TTTCGGCATC 151 GAAAGCAAGC GGCGGTTTTTGGTTGCCAGC CGCAATATAA CGCTGCTTTT 201 GGTGCTGTTT TCGCTGGCAT TTATCTGGTCGGCGCAAATT CAAACGCTGG 251 CTTTGTCGAT GTTTGCGGTG GCGGCGGCGG TCGTCGTGGCGACAAAAGAA 301 CTGATTATGT GTCTGTCGGG CAGTATTTTA aggtctGCCA CCCAGCAATA351 CTCGGTCGGC GACTATATCG AAATCAACGG CCTGCGCGGG CGCGTGGTCG 401ACATCAATCT GTTGAACACG CTGATGATGC AGGTCGGTCC GAACCCCTTG 451 GTCGGACAGCTTGCGGGAAC CACCGTTTCT TTCCCCAACA GCCTGTTGTT 501 GAGCCACCCC GTGCGCCGCGACAATATTTT GGGCGACTAT GTCATCCATA 551 CGGTCGAAAT CCCCGTTCCC ATCCATTTGGATTCGGATGA AGCCGTATGC 601 CGTCTGAAAG CCGTACTCGA GCCCTTGTGC GCGCCCTACATCCCCGCCAT 651 TCAGCGGTAT TTGGAAAACG TGCAGGCGGA AAAACTGTTT ATCACGCCCG701 CCGCCAGGCC GCGCGTTACC CGCGTACCGT ACGACGACAA GGCATACCGC 751ATCATCGTCC GCTTCGCCTC CCCCGTTTCA AAGCGGCTGG AAATCCAACA 801 GGCGGTTATGGACGAATTTT TGCGCGTACA ATACCGCCTG TTAAATCATC 851 CCGCCGgctc cgAAACACTTTAAThis corresponds to the amino acid sequence <SEQ ID 476; ORF 127.ng>:

g127.pep 1 MEIWNMLNTW PDAVPIRAEA AESVAAVAAL LLARALLLNI HFRRHPDFGI 51ESKRRFLVAS RNITLLLVLF SLAFIWSAQI QTLALSMFAV AAAVVVATKE 101 LIMCLSGSILRSATQQYSVG DYIEINGLRG RVVDINLLNT LMMQVGPNPL 151 VGQLAGTTVS FPNSLLLSHPVRRDNILGDY VIHTVEIPVP IHLDSDEAVC 201 RLKAVLEPLC APYIPAIQRY LENVQAEKLFITPAARPRVT RVPYDDKAYR 251 IIVRFASPVS KRLEIQQAVM DEFLRVQYRL LNHPAGSETL *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 477>:

m127.seq 1 ATGGAAATAT GGAATATGTT GGACACTTGG CTCGGTGCCG TCCCGATACG 51TGCGGAGGCG GTCGAATCCG TGGCGGCGGT TGCGGCTTTG CTGCTGGCGC 101 GCGCCCTTCTGTTGAATATC CACTTCAAAC GGCATCCGGA TTTCGGCATC 151 GAAAGCAAGC GGCGGTTTTTGGTTGCCAGC CGCAATATAA CGCTGCTTTT 201 GGTGCTGTTT TCGCTGGCAT TTATCTGGTCGGCGCAAATC CAAACGCTGG 251 CTTTGTCGAT GTTTGCGGTG GCGGCGGCGG TCGTCGTGGCGACGAAGGAA 301 CTGATTATGT GTCTGTCGGG CAGTATTTTA AGGTCTGCCA CCCAGCAATA351 CTCGGTCGGC GACTATATCG AAATCAACGG CCTGCGCGGG CGCGTGGTCG 401ACATCAACCT GTTGAACACG CTGATGATGC AGGTCGGTCC GAACCCCTTG 451 GTCGGACAGCTTGCGGGAAC CACCGTTTCT TTCCCCAACA GCCTGTTGTT 501 GAGCCACCCC GTGCGCCGCGACAATATTTT GGGCGACTAT GTCATCCATA 551 CGGTCGAAAT CCCCGTTCCC ATCCATTTGGATTCGGATGA AGCCGTATGC 601 CGTCTGAAAG CCGTACTCGA GCCCTTGTGC GCGCCCTACATCCCCGCCAT 651 CCAACGGsAT TTGGAAAACG TGCAGGCGGA AAAACTGTTT ATCACGCCCG701 CCGCCAGACC GCGCGTTACC CGCGTGCCGT ACGATGACAA GGCATACCGC 751ATCATCGTCC GCTTCGCTTC CCCCGTTTCA AAGCGGCTGG AAATCCAACA 801 GGCGGTTATGGACGAATTTT TGCGCGTACA ATACCGCCTG TTAAATCACC 851 CCGCCGGCTC CGAAACACTTTAAThis corresponds to the amino acid sequence <SEQ ID 478; ORF 127>:

m127.pep 1 MEIWNMLDTW LGAVPIRAEA VESVAAVAAL LLARALLLNI HFKRHPDFGI 51ESKRRFLVAS RNITLLLVLF SLAFIWSAQI QTLALSMFAV AAAVVVATKE 101 LIMCLSGSILRSATQQYSVG DYIEINGLRG RVVDINLLNT LMMQVGPNPL 151 VGQLAGTTVS FPNSLLLSHPVRRDNILGDY VIHTVEIPVP IHLDSDEAVC 201 RLKAVLEPLC APYIPAIQRX LENVQAEKLFITPAARPRVT RVPYDDKAYR 251 IIVRFASPVS KRLEIQQAVM DEFLRVQYRL LNHPAGSETL *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 127 shows 97.9% identity over a 290 aa overlap with a predicted ORF(ORF 127.ng) from N. gonorrhoeae:

m127/g127         10        20        30        40        50        60m127.pep MEIWNMLDTWLGAVPIRAEAVESVAAVAALLLARALLLNIHFKRHPDFGIESKRRFLVAS|||||||:||  ||||||||:|||||||||||||||||||||:||||||||||||||||| g127MEIWNMLNTWPDAVPIRAEAAESVAAVAALLLARALLLNIHFRRHPDFGIESKRRFLVAS        10        20        30        40        50        60        70        80        90       100       110       120 m127.pepRNITLLLVLFSLAFIWSAQIQTLALSMFAVAAAVVVATKELIMCLSGSILRSATQQYSVG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g127RNITLLLVLFSLAFIWSAQIQTLALSMFAVAAAVVVATKELIMCLSGSILRSATQQYSVG        70        80        90       100       110       120       130       140       150       160       170       180 m127.pepDYIEINGLRGRVVDINLLNTLMMQVGPNPLVGQLAGTTVSFPNSLLLSHPVRRDNILGDY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g127DYIEINGLRGRVVDINLLNTLMMQVGPNPLVGQLAGTTVSFPNSLLLSHPVRRDNILGDY       130       140       150       160       170       180       190       200       210       220       230       240 m127.pepVIHTVEIPVPIHLDSDEAVCRLKAVLEPLCAPYIPAIQRXLENVQAEKLFITPAARPRVT||||||||||||||||||||||||||||||||||||||| |||||||||||||||||||| g127VIHTVEIPVPIHLDSDEAVCRLKAVLEPLCAPYIPAIQRYLENVQAEKLFITPAARPRVT       190       200       210       220       230       240       250       260       270       280       290 m127.pepRVPYDDKAYRIIVRFASPVSKRLEIQQAVMDEFLRVQYRLLNHPAGSETLX||||||||||||||||||||||||||||||||||||||||||||||||||| g127RVPYDDKAYRIIVRFASPVSKRLEIQQAVMDEFLRVQYRLLNHPAGSETLX       250       260       270       280       290The following partial DNA sequence was identified in N. meningitidis<SEQ ID 479>:

a127.seq 1 ATGGAAATAT GGAATATGTT GGACACTTGG CTCGGTGCCG TCCCGATACG 51TGCGGAGGCG GTCGAATCCG TGGCGGTGGT CGCGGCTTTG CTGCTGGCGC 101 GCGCCCTTCTGTTGAATATC CACTTCAAAC GGCATCCGGA TTTCGGCATC 151 GAAAGCAAGC GGCGGTTTTTGGTTGCCAGC CGCAATATAA CGCTGCTTTT 201 GGTGCTGTTT TCGCTGGCAT TTATCTGGTCGGCGCAAATC CAAACGCTGG 251 CTTTGTCGAT GTTTGCGGTG GCGGCGGCGG TCGTCGTGGCGACGAAGGAA 301 CTGATTATGT GTCTGTCGGG CAGCATTTTA AGGTCTGCCA CCCAGCAATA351 CTCGGTCGGC GACTATATCG AAATCAACGG CCTGCGCGGG CGCGTGGTCG 401ACATCAACCT GTTGAACACG CTGATGATGC AGGTCGGTCC GAACCCCTTG 451 GTCGGACAGCTTGCGGGAAC CACCGTTTCT TTCCCCAACA GCCTGTTGTT 501 GAGCCACCCC GTGCGCCGCGACAATATTTT GGGCGACTAC GTCATCCATA 551 CGGTCGAAAT CCCGGTTCCC ATCCATTTGGATTCGGATGA AGCCGTATGC 601 CGTCTGAAAG CCGTACTCGA GCCCTTGTGC GCGCCCTACATCCCCGCCAT 651 CCAACGGCAT TTGGAAAACG TGCAGGCGGA AAAACTGTTT ATCACGCCCG701 CCGCCAAACC GCGCGTTACC CGCGTGCCGT ACGATGACAA GGCATACCGC 751ATCATCGTCC GCTTCGCCTC CCCCGTTTCA AAGCGGCTGG AAATCCAACA 801 GGCGGTTATGGACGAATTTT TGCGCGTACA ATACCGCCTG TTAAATTACC 851 CCGCCGGCTC CGAAACACTTTAAThis corresponds to the amino acid sequence <SEQ ID 480; ORF 127.a>:

a127.pep 1 MEIWNMLDTW LGAVPIRAEA VESVAVVAAL LLARALLLNI HFKRHPDFGI 51ESKRRFLVAS RNITLLLVLF SLAFIWSAQI QTLALSMFAV AAAVVVATKE 101 LIMCLSGSILRSATQQYSVG DYIEINGLRG RVVDINLLNT LMMQVGPNPL 151 VGQLAGTTVS FPNSLLLSHPVRRDNILGDY VIHTVEIPVP IHLDSDEAVC 201 RLKAVLEPLC APYIPAIQRH LENVQAEKLFITPAAKPRVT RVPYDDKAYR 251 IIVRFASPVS KRLEIQQAVM DEFLRVQYRL LNYPAGSETL *m127/a127 98.6% identity in 290 aa overlap        10        20        30        40        50        60 m127.pepMEIWNMLDTWLGAVPIRAEAVESVAAVAALLLARALLLNIHFKRHPDFGIESKRRFLVAS|||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||| a127MEIWNMLDTWLGAVPIRAEAVESVAVVAALLLARALLLNIHFKRHPDFGIESKRRFLVAS        10        20        30        40        50        60        70        80        90       100       110       120 m127.pepRNITLLLVLFSLAFIWSAQIQTLALSMFAVAAAVVVATKELIMCLSGSILRSATQQYSVG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a127RNITLLLVLFSLAFIWSAQIQTLALSMFAVAAAVVVATKELIMCLSGSILRSATQQYSVG        70        80        90       100       110       120       130       140       150       160       170       180 m127.pepDYIEINGLRGRVVDINLLNTLMMQVGPNPLVGQLAGTTVSFPNSLLLSHPVRRDNILGDY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a127DYIEINGLRGRVVDINLLNTLMMQVGPNPLVGQLAGTTVSFPNSLLLSHPVRRDNILGDY       130       140       150       160       170       180       190       200       210       220       230       240 m127.pepVIHTVEIPVPIHLDSDEAVCRLKAVLEPLCAPYIPAIQRXLENVQAEKLFITPAARPRVT||||||||||||||||||||||||||||||||||||||| |||||||||||||||:|||| al27VIHTVEIPVPIHLDSDEAVCRLKAVLEPLCAPYIPAIQRHLENVQAEKLFITPAAKPRVT       190       200       210       220       230       240       250       260       270       280       290 m127.pepRVPYDDKAYRIIVRFASPVSKRLEIQQAVMDEFLRVQYRLLNHPAGSETLX||||||||||||||||||||||||||||||||||||||||||:|||||||| a127RVPYDDKAYRIIVRFASPVSKRLEIQQAVMDEFLRVQYRLLNYPAGSETLX       250       260       270       280       290The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 481>:

g128.seq 1 atgattgaca acgCActgct ccacttgggc gaagaaccCC GTTTTaatca 51aatccaaacc gaagACAtca AACCCGCCGT CCAAACCGCC ATCGCCGAAG 101 CGCGCGGACAAATCGCCGCC GTCAAAGCGC AAACGCACAC CGGCTGGGCG 151 AACACCGTCG AGCGTCTGACCGGCATCACC GAACGCGTCG GCAGGATTTG 201 GGGCGTCGTG TCCCATCTCA ACTCCGTCGTCGACACGCCC GAACTGCGCG 251 CCGTCTATAA CGAACTGATG CCTGAAATCA CCGTCTTCTTCACCGAAATC 301 GGACAAGACA TCGAACTGTA CAACCGCTTC AAAACCATCA AAAATTCCCC351 CGAATTTGCA ACGCTTTCCC CCGCACAAAA AACCAAGCTC GATCACGACC 401TGCGCGATTT CGTATTGAGC GGCGCGGAAC TGCCGCCCGA ACGGCAGGCA 451 GAACTGGCAAAACTGCAAAC CGAAGGCGCG CAACTTTCCG CCAAATTCTC 501 CCAAAACGTC CTAGACGCGACCGACGCGTT CGGCATTTAC TTTGACGATG 551 CCGCACCGCT TGCCGGCATT CCCGAAGACGCGCTCGCCAT GTTTGCCGCC 601 GCCGCGCAAA GCGAAGGCAA AACAGGTTAC AAAATCGGCTTGCAGATTCC 651 GCACTACCTT GCCGTTATCC AATACGCCGG CAACCGCGAA CTGCGCGAAC701 AAATCTACCG CGCCTACGTT ACCCGTGCCA GCGAACTTTC AAACGACGGC 751AAATTCGACA ACACCGCCAA CATCGACCGC ACGCTCGAAA ACGCATTGAA 801 AACCGccaaacTGCTCGGCT TTAAAAATTA CGCCGAATTG TCGCTGGCAA 851 CCAAAATGGC GGACACGCCCGAACAGGTTT TAAACTTCCT GCACGACCTC 901 GCCCGCCGCG CCAAACCCTA CGCCGAAAAAGACCTCGCCG AAGTCAAAGC 951 CTTCGCCCGC GAACACCTCG GTCTCGCCGA CCCGCAGCCGTGGGACTTGA 1001 GCTACGCCGG CGAAAAACTG CGCGAAGCCA AATACGCATT CAGCGAAACC1051 GAAGTCAAAA AATACTTCCC CGTCGGCAAA GTTCTGGCAG GCCTGTTCGC 1101CCAAATCAAA AAACTCTACG GCATCGGATT CGCCGAAAAA ACCGTTCCCG 1151 TCTGGCACAAAGACGTGCGC TATTTTGAAT TGCAACAAAA CGGCAAAACC 1201 ATCGGCGGCG TTTATATGGATTTGTACGCA CGCGAAGGCA AACGCGGCGG 1251 CGCGTGGATG AACGACtaca AAGGCCGCCGCCGCTTTGCC GACGgcacGC 1301 TGCAACTGCC CACCGCCTAC CTCGTCTGCA ACTTCGCCCCGCCCGTCGGC 1351 GGCAAAGAAG CGCGTTTAAG CCACGACGAA ATCCTCACCC TCTTCCACGA1401 AacCGGCCAC GGACTGCACC ACCTGCTTAC CCAAGTGGAC GAACTGGGCG 1451TGTCCGGCAT CAAcggcgtA GAATGGGACG CGGTCGAACT GCCCAGCCAG 1501 TTTATGGAAAACTTCGTTTG GGAATACAAT GTATTGGCAC AAATGTCCGC 1551 CCACGAAGAA AccgGCGAGCCCCTGCCGAA AGAACTCTTC GACAAAATGC 1601 TcgcCGCCAA AAACTTCCAG CGCGGTATGTTCCTCGTCCG GCAAATGGAG 1651 TTCGCCCTCT TCGATATGAT GATTTACAGT GAAAGCGACGAATGCCGTCT 1701 GAAAAACTGG CAGCAGGTTT TAGACAGCGT GCGCAAAGAA GTcGCCGTCA1751 TCCAACCGCC CGAATACAAC CGCTTCGCCA ACAGCTTCGG CCacatctTC 1801GCcggcGGCT ATTCCGCAGG CTATTACAGC TACGCATGGG CCGAAGTCCt 1851 cAGCACCGATGCCTACGCCG CCTTTGAAGA AAGcGACGac gtcGCCGCCA 1901 CAGGCAAACG CTTCTGGCAAGAAAtccttg ccgtcggcgg ctCCCGCAGC 1951 gcgGCGGAAT CCTTCAAAGC CTTCCGCGGACGCGAACCGA GCATAGACGC 2001 ACTGCTGCGC CAaagcggtT TCGACAACGC gGCttgAThis corresponds to the amino acid sequence <SEQ ID 482; ORF 128.ng>:

g128.pep 1 MIDNALLHLG EEPRFNQIQT EDIKPAVQTA IAEARGQIAA VKAQTHTGWA 51NTVERLTGIT ERVGRIWGVV SHLNSVVDTP ELRAVYNELM PEITVFFTEI 101GQDIELYNRF KTIKNSPEFA TLSPAQKTKL DHDLRDFVLS GAELPPERQA 151ELAKLQTEGA QLSAKFSQNV LDATDAFGIY FDDAAPLAGI PEDALAMFAA 201AAQSEGKTGY KIGLQIPHYL AVIQYAGNRE LREQIYRAYV TRASELSNDG 251KFDNTANIDR TLENALKTAK LLGFKNYAEL SLATKMADTP EQVLNFLHDL 301ARRAKPYAEK DLAEVKAFAR EHLGLADPQP WDLSYAGEKL REAKYAFSET 351EVKKYFPVGK VLAGLFAQIK KLYGIGFAEK TVPVWHKDVR YFELQQNGKT 401IGGVYMDLYA REGKRGGAWM NDYKGRRRFA DGTLQLPTAY LVCNFAPPVG 451GKEARLSHDE ILTLFHETGH GLHHLLTQVD ELGVSGINGV EWDAVELPSQ 501FMENFVWEYN VLAQMSAHEE TGEPLPKELF DKMLAAKNFQ RGMFLVRQME 551FALFDMMIYS ESDECRLKNW QQVLDSVRKE VAVIQPPEYN RFANSFGHIF 601AGGYSAGYYS YAWAEVLSTD AYAAFEESDD VAATGKRFWQ EILAVGGSRS 651AAESFKAFRG REPSIDALLR QSGFDNAA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 483>:

m128.seq (partial) 1ATGACTGACA ACGCACTGCT CCATTTGGGC GAAGAACCCC GTTTTGATCA 51AATCAAAACC GAAGACATCA AACCCGCCCT GCAAACCGCC ATCGCCGAAG 101CGCGCGAACA AATCGCCGCC ATCAAAGCCC AAACGCACAC CGGCTGGGCA 151AACACTGTCG AACCCCTGAC CGGCATCACC GAACGCGTCG GCAGGATTTG 201GGGCGTGGTG TCGCACCTCA ACTGCGTCGC CGACACGCCC GAACTGCGCG 251CCGTCTATAA CGAACTGATG CCCGAAATCA CCGTCTTCTT CACCGAAATC 301GGACAAGACA TCGAGCTGTA CAACCGCTTC AAAACCATCA AAAATTCCCC 351CGAATTCGAC ACCCTCTCCC CCGCACAAAA AACCAAACTC AACCAC 1TACGCCAGCG AAAAACTGCG CGAAGCCAAA TACGCGTTCA GCGAAACCGA 51wGTCAAAAAA TAyTTCCCyG TCGGCAAwGT ATTAAACGGA CTGTTCGCCC 101AAmTCAAAAA ACTmTACGGC ATCGGATTTA CCGAAAAAAC yGTCCCCGTC 151TGGCACAAAG ACGTGCGCTA TTkTGAATTG CAACAAAACG GCGAAmCCAT 201AGGCGGCGTT TATATGGATT TGTACGCACG CGAAGGCAAA CGCGGCGGCG 251CGTGGATGAA CGACTACAAA GGCCGCCGCC GTTTTTCAGA CGGCACGCTG 301CAAyTGCCCA CCGCCTACCT CGTCTGCAAC TTCGCCCCAC CCGTCGGCGG 351CAGGGAAGCC CGCyTGAGCC ACGACGAAAT CCTCATCCTC TTCCACGAAA 401CCGGACACGG GCTGCACCAC CTGCTTACCC AAGTGGACGA ACTGGGCGTA 451TCCGGCATCA ACGGCGTAkA ATGGGACGCG GTCGAACTGC CCAGCCAGTT 501TATGGAAAAT TTCGTTTGGG AATACAATGT CTTGGCACAA mTGTCAGCCC 551ACGAAGAAAC CGGcgTTCCC yTGCCGAAAG AACTCTTsGA CAAAwTGCTC 601GCCGCCAAAA ACTTCCAAsG CGGCATGTTC yTsGTCCGGC AAwTGGAGTT 651CGCCCTCTTT GATATGATGA TTTACAGCGA AGACGACGAA GGCCGTCTGA 701AAAACTGGCA ACAGGTTTTA GACAGCGTGC GCAAAAAAGT CGCCGTCATC 751CAGCCGCCCG AATACAACCG CTTCGCCTTG AGCTTCGGCC ACATCTTCGC 801AGGCGGCTAT TCCGCAGCTn ATTACAGCTA CGCGTGGGCG GAAGTATTGA 851GCGCGGACGC ATACGCCGCC TTTGAAGAAA GCGACGATGT CGCCGCCACA 901GGCAAACGCT TTTGGCAGGA AATCCTCGCC GTCGGGGnAT CGCGCAGCGG 951nGCAGAATCC TTCAAAGCCT TCCGCGGCCG CGAACCGAGC ATAGACGCAC 1001TCTTGCGCCA CAGCGGTTTC GACAACGCGG TCTGAThis corresponds to the amino acid sequence <SEQ ID 484; ORF 128>:

m128.pep (partial) 1MTDNALLHLG EEPRFDQIKT EDIKPALQTA IAEAREQIAA IKAQTHTGWA 51NTVEPLTGIT ERVGRIWGVV SHLNCVADTP ELRAVYNELM PEITVFFTEI 101GQDIELYNRF KTIKNSPEFD TLSPAQKTKL NH // 1YASEKLREAK YAFSETXVKK YFPVGXVLNG LFAQXKKLYG IGFTEKTVPV 51WHKDVRYXEL QQNGEXIGGV YMDLYAREGK RGGAWMNDYK GRRRFSDGTL 101QLPTAYLVCN FAPPVGGREA RLSHDEILIL FHETGHGLHH LLTQVDELGV 151SGINGVXWDA VELPSQFMEN FVWEYNVLAQ XSAHEETGVP LPKELXDKXL 201AAKNFQXGMF XVRQXEFALF DMMIYSEDDE GRLKNWQQVL DSVRKKVAVI 251QPPEYNRFAL SFGHIFAGGY SAAXYSYAWA EVLSADAYAA FEESDDVAAT 301GKRFWQEILA VGXSRSGAES FKAFRGREPS IDALLRHSGF DNAV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 128 shows 91.7% identity over a 475 aa overlap with a predicted ORF(ORF 128.ng) from N. gonorrhoeae:

m128/g128         10        20        30        40        50        60g128.pep MIDNALLHLGEEPRFNQIQTEDIKPAVQTAIAEARGQIAAVKAQTHTGWANTVERLTGIT ||||||||||||||:||:|||||||:|||||||| ||||:||||||||||||| ||||| m128MTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT        10        20        30        40        50        60        70        80        90       100       110       120 g128.pepERVGRIWGVVSHLNSVVDTPELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFA|||||||||||||| |:|||||||||||||||||||||||||||||||||||||||||| m128ERVGRIWGVVSHLNCVADTPELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFD        70        80        90       100       110       120       130       140       150       160       170       180 g128.pepTLSPAQKTKLDHDLRDFVLSGAELPPERQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY||||||||||:| m128 TLSPAQKTKLNH        130 //                                 340       350       360 g128.pep                              YAGEKLREAKYAFSETEVKKYFPVGKVLAG||:||||||||||||| |||||||| || | m128 YASEKLREAKYAFSETXVKKYFPVGXVLNG                                      10        20        30   370       380       390       400       410       420 g128.pepLFAQIKKLYGIGFAEKTVPVWHKDVRYFELQQNGKTIGGVYMDLYAREGKRGGAWMNDYK ||||||||||||:||||||||||||| ||||||::|||||||||||||||||||||||| m128LFAQXKKLYGIGFTEKTVPVWHKDVRYXELQQNGEXIGGVYMDLYAREGKRGGAWMNDYK        40        50        60        70        80        90   430       440       450       460       470       480 g128.pepGRRRFADGTLQLPTAYLVCNFAPPVGGKEARLSHDEILTLFHETGHGLHHLLTQVDELGV|||||:|||||||||||||||||||||:|||||||||| ||||||||||||||||||||| m128GRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILILFHETGHGLHHLLTQVDELGV       100       110       120       130       140       150   490       500       510       520       530       540 g128.pepSGINGVEWDAVELPSQFMENFVWEYNVLAQMSAHEETGEPLPKELFDKMLAAKNFQRGMF ||||||||||||||||||||||||||||| ||||||| |||||| || ||||||| ||| m128SGINGVXWDAVELPSQFMENFVWEYNVLAQXSAHEETGVPLPKELXDKXLAAKNFQXGMF       160       170       180       190       200       210   550       560       570       580       590       600 g128.pepLVRQMEFALFDMMIYSESDECRLKNWQQVLDSVRKEVAVIQPPEYNRFANSFGHIFAGGY  ||||||||||||||: || ||||||||||||||: ||||||||||||| ||||||||| m128XVRQXEFALFDMMIYSEDDEGRLKNWQQVLDSVRKKVAVIQPPEYNRFALSFGHIFAGGY       220       230       240       250       260       270   610       620       630       640       650       660 g128.pepSAGYYSYAWAEVLSTDAYAAFEESDDVAATGKRFWQEILAVGGSRSAAESFKAFRGREPS||: ||||||||||:||||||||||||||||||||||||||| |||:||||||||||||| m128SAAXYSYAWAEVLSADAYAAFEESDDVAATGKRFWQEILAVGXSRSGAESFKAFRGREPS       280       290       300       310       320       330   670      679 g128.pep IDALLRQSGFDNAAX ||||||:||||||: m128IDALLRHSGFDNAVX        340The following partial DNA sequence was identified in N. meningitidis<SEQ ID 485>:

a128.seq 1 ATGACTGACA ACGCACTGCT CCATTTGGGC GAAGAACCCC GTTTTGATCA 51AATCAAAACC GAAGACATCA AACCCGCCCT GCAAACCGCC ATTGCCGAAG 101CGCGCGAACA AATCGCCGCC ATCAAAGCCC AAACGCACAC CGGCTGGGCA 151AACACTGTCG AACCCCTGAC CGGCATCACC GAACGCGTCG GCAGGATTTG 201GGGCGTGGTG TCGCACCTCA ACTCCGTCAC CGACACGCCC GAACTGCGCG 251CCGCCTACAA TGAATTAATG CCCGAAATTA CCGTCTTCTT CACCGAAATC 301GGACAAGACA TCGAGCTGTA CAACCGCTTC AAAACCATCA AAAACTCCCC 351CGAGTTCGAC ACCCTCTCCC ACGCGCAAAA AACCAAACTC AACCACGATC 401TGCGCGATTT CGTCCTCAGC GGCGCGGAAC TGCCGCCCGA ACAGCAGGCA 451GAATTGGCAA AACTGCAAAC CGAAGGCGCG CAACTTTCCG CCAAATTCTC 501CCAAAACGTC CTAGACGCGA CCGACGCGTT CGGCATTTAC TTTGACGATG 551CCGCACCGCT TGCCGGCATT CCCGAAGACG CGCTCGCCAT GTTTGCCGCT 601GCCGCGCAAA GCGAAGGCAA AACAGGCTAC AAAATCGGTT TGCAGATTCC 651GCACTACCTC GCCGTCATCC AATACGCCGA CAACCGCAAA CTGCGCGAAC 701AAATCTACCG CGCCTACGTT ACCCGCGCCA GCGAGCTTTC AGACGACGGC 751AAATTCGACA ACACCGCCAA CATCGACCGC ACGCTCGAAA ACGCCCTGCA 801AACCGCCAAA CTGCTCGGCT TCAAAAACTA CGCCGAATTG TCGCTGGCAA 851CCAAAATGGC GGACACCCCC GAACAAGTTT TAAACTTCCT GCACGACCTC 901GCCCGCCGCG CCAAACCCTA CGCCGAAAAA GACCTCGCCG AAGTCAAAGC 951CTTCGCCCGC GAAAGCCTCG GCCTCGCCGA TTTGCAACCG TGGGACTTGG 1001GCTACGCCGG CGAAAAACTG CGCGAAGCCA AATACGCATT CAGCGAAACC 1051GAAGTCAAAA AATACTTCCC CGTCGGCAAA GTATTAAACG GACTGTTCGC 1101CCAAATCAAA AAACTCTACG GCATCGGATT TACCGAAAAA ACCGTCCCCG 1151TCTGGCACAA AGACGTGCGC TATTTTGAAT TGCAACAAAA CGGCGAAACC 1201ATAGGCGGCG TTTATATGGA TTTGTACGCA CGCGAAGGCA AACGCGGCGG 1251CGCGTGGATG AACGACTACA AAGGCCGCCG CCGTTTTTCA GACGGCACGC 1301TGCAACTGCC CACCGCCTAC CTCGTCTGCA ACTTCACCCC GCCCGTCGGC 1351GGCAAAGAAG CCCGCTTGAG CCATGACGAA ATCCTCACCC TCTTCCACGA 1401AACCGGACAC GGCCTGCACC ACCTGCTTAC CCAAGTCGAC GAACTGGGCG 1451TATCCGGCAT CAACGGCGTA GAATGGGACG CAGTCGAACT GCCCAGTCAG 1501TTTATGGAAA ATTTCGTTTG GGAATACAAT GTCTTGGCGC AAATGTCCGC 1551CCACGAAGAA ACCGGCGTTC CCCTGCCGAA AGAACTCTTC GACAAAATGC 1601TCGCCGCCAA AAACTTCCAA CGCGGAATGT TCCTCGTCCG CCAAATGGAG 1651TTCGCCCTCT TTGATATGAT GATTTACAGC GAAGACGACG AAGGCCGTCT 1701GAAAAACTGG CAACAGGTTT TAGACAGCGT GCGCAAAGAA GTCGCCGTCG 1751TCCGACCGCC CGAATACAAC CGCTTCGCCA ACAGCTTCGG CCACATCTTC 1801GCAGGCGGCT ATTCCGCAGG CTATTACAGC TACGCGTGGG CGGAAGTATT 1851GAGCGCGGAC GCATACGCCG CCTTTGAAGA AAGCGACGAT GTCGCCGCCA 1901CAGGCAAACG CTTTTGGCAG GAAATCCTCG CCGTCGGCGG ATCGCGCAGC 1951GCGGCAGAAT CCTTCAAAGC CTTCCGCGGA CGCGAACCGA GCATAGACGC 2001ACTCTTGCGC CACAGCGGCT TCGACAACGC GGCTTGAThis corresponds to the amino acid sequence <SEQ ID 486; ORF 128.a>:

a128.pep 1 MTDNALLHLG EEPRFDQIKT EDIKPALQTA IAEAREQIAA IKAQTHTGWA 51NTVEPLTGIT ERVGRIWGVV SHLNSVTDTP ELRAAYNELM PEITVFFTEI 101GQDIELYNRF KTIKNSPEFD TLSHAQKTKL NHDLRDFVLS GAELPPEQQA 151ELAKLQTEGA QLSAKFSQNV LDATDAFGIY FDDAAPLAGI PEDALAMFAA 201AAQSEGKTGY KIGLQIPHYL AVIQYADNRK LREQIYRAYV TRASELSDDG 251KFDNTANIDR TLENALQTAK LLGFKNYAEL SLATKMADTP EQVLNFLHDL 301ARRAKPYAEK DLAEVKAFAR ESLGLADLQP WDLGYAGEKL REAKYAFSET 351EVKKYFPVGK VLNGLFAQIK KLYGIGFTEK TVPVWHKDVR YFELQQNGET 401IGGVYMDLYA REGKRGGAWM NDYKGRRRFS DGTLQLPTAY LVCNFTPPVG 451GKEARLSHDE ILTLFHETGH GLHHLLTQVD ELGVSGINGV EWDAVELPSQ 501FMENFVWEYN VLAQMSAHEE TGVPLPKELF DKMLAAKNFQ RGMFLVRQME 551FALFDMMIYS EDDEGRLKNW QQVLDSVRKE VAVVRPPEYN RFANSFGHIF 601AGGYSAGYYS YAWAEVLSAD AYAAFEESDD VAATGKRFWQ EILAVGGSRS 651AAESFKAFRG REPSIDALLR HSGFDNAA* m128/a12866.0% identity in 677 aa overlap         10        20        30        40        50        60 m128.pep MTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a128 MTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT         10        20        30        40        50        60         70        80        90       100       110       120 m128.pep ERVGRIWGVVSHLNCVADTPELRAVYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFD |||||||||||||| |:|||||||:||||||||||||||||||||||||||||||||||| a128 ERVGRIWGVVSHLNSVTDTPELRAAYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFD         70        80        90       100       110       120        130 m128.pep TLSPAQKTKLNH------------------------------------------------  ||||||||||| a128 TLSHAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY        130       140       150       160       170       180 m128.pep ------------------------------------------------------------ a128 FDDAAPLAGIPEDALAMFAAAAQSEGKTGYKIGLQIPHYLAVIQYADNRKLREQIYRAYV        190       200       210       220       230       240 m128.pep ------------------------------------------------------------ a128 TRASELSDDGKFDNTANIDRTLENALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDL        250       260       270       280       290       300                                        140       150 m128.pep ----------------------------------YASEKLREAKYAFSETXVKKYFPVGX                                   ||: ||||||||||||| |||||||| a128 ARRAKPYAEKDLAEVKAFARESLGLADLQPWDLGYAGEKLREAKYAFSETEVKKYFPVGK        310       320       330       340       350       360160       170       180       190       200       210 m128.pep VLNGLFAQXKKLYGIGFTEKTVPVWHKDVRYXELQQNGEXIGGVYMDLYAREGKRGGAWM  |||||||||||||||||||||||||||||| |||||||: |||||||||||||||||||| a128 VLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGETIGGVYMDLYAREGKRGGAWM        370       380       390       400       410       420220       230       240       250       260       270 m128.pep NDYKGRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILILFHETGHGLHHLLTQVD |||||||||||||||||||||||||:|||||:|||||||||| ||||||||||||||||| a128 NDYKGRRRFSDGTLQLPTAYLVCNFTPPVGGKEARLSHDEILTLFHETGHGLHHLLTQVD        430       440       450       460       470       480280       290       300       310       320       330 m128.pep ELGVSGINGVXWDAVELPSQFMENFVWEYNVLAQXSAHEETGVPLPKELXDKXLAAKNFQ |||||||||| ||||||||||||||||||||||| |||||||||||||| || ||||||| a128 ELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSAHEETGVPLPKELFDKMLAAKNFQ        490       500       510       520       530       540340       350       360       370       380       390 m128.pep XGMFXVRQXEFALFDMMIYSEDDEGRLKNWQQVLDSVRKKVAVIQPPEYNRFALSFGHIF   ||| |||||||||||||||||||||||||||||||||:|||::|||||||| |||||| a128 RGMFLVRQMEFALFDMMIYSEDDEGRLKNWQQVLDSVRKEVAVVRPPEYNRFANSFGHIF        550       560       570       580       590       600400       410       420       430       440       450 m128.pep AGGYSAAXYSYAWAEVLSADAYAAFEESDDVAATGKRFWQEILAVGXSRSGAESFKAFRG ||||||: |||||||||||||||||||||||||||||||||||||| |||: ||||||||| a128 AGGYSAGYYSYAWAEVLSADAYAAFEESDDVAATGKRFWQEILAVGGSRSAAESFKAFRG        610       620       630       640       650       660460       470 m128.pep  REPSIDALLRHSGFDNAVX  |||||||||||||||||: a128 REPSIDALLRHSGFDNAAX         670The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 487>:

g128-1.seq (partial) 1ATGATTGACA ACGCACTGCT CCACTTGGGC GAAGAACCCC GTTTTAATCA 51AATCAAAACC GAAGACATCA AACCCGCCGT CCAAACCGCC ATCGCCGAAG 101CGCGCGGACA AATCGCCGCC GTCAAAGCGC AAACGCACAC CGGCTGGGCG 151AACACCGTCG AGCGTCTGAC CGGCATCACC GAACGCGTCG GCAGGATTTG 201GGGCGTCGTG TCCCATCTCA ACTCCGTCGT CGACACGCCC GAACTGCGCG 251CCGTCTATAA CGAACTGATG CCTGAAATCA CCGTCTTCTT CACCGAAATC 301GGACAAGACA TCGAACTGTA CAACCGCTTC AAAACCATCA AAAATTCCCC 351CGAATTTGCA ACGCTTTCCC CCGCACAAAA AACCAAGCTC GATCACGACC 401TGCGCGATTT CGTATTGAGC GGCGCGGAAC TGCCGCCCGA ACGGCAGGCA 451GAACTGGCAA AACTGCAAAC CGAAGGCGCG CAACTTTCCG CCAAATTCTC 501CCAAAACGTC CTAGACGCGA CCGACGCGTT CGGCATTTAC TTTGACGATG 551CCGCACCGCT TGCCGGCATT CCCGAAGACG CGCTCGCCAT GTTTGCCGCC 601GCCGCGCAAA GCGAAGGCAA AACAGGTTAC AAAATCGGCT TGCAGATTCC 651GCACTACCTT GCCGTTATCC AATACGCCGG CAACCGCGAA CTGCGCGAAC 701AAATCTACCG CGCCTACGTT ACCCGTGCCA GCGAACTTTC AAACGACGGC 751AAATTCGACA ACACCGCCAA CATCGACCGC ACGCTCGAAA ACGCATTGAA 801AACCGCCAAA CTGCTCGGCT TTAAAAATTA CGCCGAATTG TCGCTGGCAA 851CCAAAATGGC GGACACGCCC GAACAGGTTT TAAACTTCCT GCACGACCTC 901GCCCGCCGCG CCAAACCCTA CGCCGAAAAA GACCTCGCCG AAGTCAAAGC 951CTTCGCCCGC GAACACCTCG GTCTCGCCGA CCCGCAGCCG TGGGACTTGA 1001GCTACGCCGG CGAAAAACTG CGCGAAGCCA AATACGCATT CAGCGAAACC 1051GAAGTCAAAA AATACTTCCC CGTCGGCAAA GTTCTGGCAG GCCTGTTCGC 1101CCAAATCAAA AAACTCTACG GCATCGGATT CGCCGAAAAA ACCGTTCCCG 1151TCTGGCACAA AGACGTGCGC TATTTTGAAT TGCAACAAAA CGGCAAAACC 1201ATCGGCGGCG TTTATATGGA TTTGTACGCA CGCGAAGGCA AACGCGGCGG 1251CGCGTGGATG AACGACTACA AAGGCCGCCG CCGCTTTGCC GACGGCACGC 1301TGCAACTGCC CACCGCCTAC CTCGTCTGCA ACTTCGCCCC GCCCGTCGGC 1351GGCAAAGAAG CGCGTTTAAG CCACGACGAA ATCCTCACCC TCTTCCACGA 1401AACCGGCCAC GGACTGCACC ACCTGCTTAC CCAAGTGGAC GAACTGGGCG 1451TGTCCGGCAT CAACGGCGTA AAAThis corresponds to the amino acid sequence <SEQ ID 488; ORF 128-1.ng>:

g128-1.pep (partial) 1MIDNALLHLG EEPRFNQIKT EDIKPAVQTA IAEARGQIAA VKAQTHTGWA 51NTVERLTGIT ERVGRIWGVV SHLNSVVDTP ELRAVYNELM PEITVFFTEI 101GQDIELYNRF KTIKNSPEFA TLSPAQKTKL DHDLRDFVLS GAELPPERQA 151ELAKLQTEGA QLSAKFSQNV LDATDAFGIY FDDAAPLAGI PEDALAMFAA 201AAQSEGKTGY KIGLQIPHYL AVIQYAGNRE LREQIYRAYV TRASELSNDG 251KFDNTANIDR TLENALKTAK LLGFKNYAEL SLATKMADTP EQVLNFLHDL 301ARRAKPYAEK DLAEVKAFAR EHLGLADPQP WDLSYAGEKL REAKYAFSET 351EVKKYFPVGK VLAGLFAQIK KLYGIGFAEK TVPVWHKDVR YFELQQNGKT 401IGGVYMDLYA REGKRGGAWM NDYKGRRRFA DGTLQLPTAY LVCNFAPPVG 451GKEARLSHDE ILTLFHETGH GLHHLLTQVD ELGVSGINGV KThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 489>:

m128-1.seq 1 ATGACTGACA ACGCACTGCT CCATTTGGGC GAAGAACCCC GTTTTGATCA 51AATCAAAACC GAAGACATCA AACCCGCCCT GCAAACCGCC ATCGCCGAAG 101CGCGCGAACA AATCGCCGCC ATCAAAGCCC AAACGCACAC CGGCTGGGCA 151AACACTGTCG AACCCCTGAC CGGCATCACC GAACGCGTCG GCAGGATTTG 201GGGCGTGGTG TCGCACCTCA ACTCCGTCGC CGACACGCCC GAACTGCGCG 251CCGTCTATAA CGAACTGATG CCCGAAATCA CCGTCTTCTT CACCGAAATC 301GGACAAGACA TCGAGCTGTA CAACCGCTTC AAAACCATCA AAAATTCCCC 351CGAATTCGAC ACCCTCTCCC CCGCACAAAA AACCAAACTC AACCACGATC 401TGCGCGATTT CGTCCTCAGC GGCGCGGAAC TGCCGCCCGA ACAGCAGGCA 451GAACTGGCAA AACTGCAAAC CGAAGGCGCG CAACTTTCCG CCAAATTCTC 501CCAAAACGTC CTAGACGCGA CCGACGCGTT CGGCATTTAC TTTGACGATG 551CCGCACCGCT TGCCGGCATT CCCGAAGACG CGCTCGCCAT GTTTGCCGCC 601GCCGCGCAAA GCGAAAGCAA AACAGGCTAC AAAATCGGCT TGCAGATTCC 651ACACTACCTC GCCGTCATCC AATACGCCGA CAACCGCGAA CTGCGCGAAC 701AAATCTACCG CGCCTACGTT ACCCGCGCCA GCGAACTTTC AGACGACGGC 751AAATTCGACA ACACCGCCAA CATCGACCGC ACGCTCGCAA ACGCCCTGCA 801AACCGCCAAA CTGCTCGGCT TCAAAAACTA CGCCGAATTG TCGCTGGCAA 851CCAAAATGGC GGACACGCCC GAACAAGTTT TAAACTTCCT GCACGACCTC 901GCCCGCCGCG CCAAACCCTA CGCCGAAAAA GACCTCGCCG AAGTCAAAGC 951CTTCGCCCGC GAAAGCCTGA ACCTCGCCGA TTTGCAACCG TGGGACTTGG 1001GCTACGCCAG CGAAAAACTG CGCGAAGCCA AATACGCGTT CAGCGAAACC 1051GAAGTCAAAA AATACTTCCC CGTCGGCAAA GTATTAAACG GACTGTTCGC 1101CCAAATCAAA AAACTCTACG GCATCGGATT TACCGAAAAA ACCGTCCCCG 1151TCTGGCACAA AGACGTGCGC TATTTTGAAT TGCAACAAAA CGGCGAAACC 1201ATAGGCGGCG TTTATATGGA TTTGTACGCA CGCGAAGGCA AACGCGGCGG 1251CGCGTGGATG AACGACTACA AAGGCCGCCG CCGTTTTTCA GACGGCACGC 1301TGCAACTGCC CACCGCCTAC CTCGTCTGCA ACTTCGCCCC ACCCGTCGGC 1351GGCAGGGAAG CCCGCCTGAG CCACGACGAA ATCCTCATCC TCTTCCACGA 1401AACCGGACAC GGGCTGCACC ACCTGCTTAC CCAAGTGGAC GAACTGGGCG 1451TATCCGGCAT CAACGGCGTA GAATGGGACG CGGTCGAACT GCCCAGCCAG 1501TTTATGGAAA ATTTCGTTTG GGAATACAAT GTCTTGGCAC AAATGTCAGC 1551CCACGAAGAA ACCGGCGTTC CCCTGCCGAA AGAACTCTTC GACAAAATGC 1601TCGCCGCCAA AAACTTCCAA CGCGGCATGT TCCTCGTCCG GCAAATGGAG 1651TTCGCCCTCT TTGATATGAT GATTTACAGC GAAGACGACG AAGGCCGTCT 1701GAAAAACTGG CAACAGGTTT TAGACAGCGT GCGCAAAAAA GTCGCCGTCA 1751TCCAGCCGCC CGAATACAAC CGCTTCGCCT TGAGCTTCGG CCACATCTTC 1801GCAGGCGGCT ATTCCGCAGG CTATTACAGC TACGCGTGGG CGGAAGTATT 1851GAGCGCGGAC GCATACGCCG CCTTTGAAGA AAGCGACGAT GTCGCCGCCA 1901CAGGCAAACG CTTTTGGCAG GAAATCCTCG CCGTCGGCGG ATCGCGCAGC 1951GCGGCAGAAT CCTTCAAAGC CTTCCGCGGC CGCGAACCGA GCATAGACGC 2001ACTCTTGCGC CACAGCGGTT TCGACAACGC GGTCTGAThis corresponds to the amino acid sequence <SEQ ID 490; ORF 128-1>:

m128-1.pep. 1 MTDNALLHLG EEPRFDQIKT EDIKPALQTA IAEAREQIAA IKAQTHTGWA 51NTVEPLTGIT ERVGRIWGVV SHLNSVADTP ELRAVYNELM PEITVFFTEI 101GQDIELYNRF KTIKNSPEFD TLSPAQKTKL NHDLRDFVLS GAELPPEQQA 151ELAKLQTEGA QLSAKFSQNV LDATDAFGIY FDDAAPLAGI PEDALAMFAA 201AAQSESKTGY KIGLQIPHYL AVIQYADNRE LREQIYRAYV TRASELSDDG 251KFDNTANIDR TLANALQTAK LLGFKNYAEL SLATKMADTP EQVLNFLHDL 301ARRAKPYAEK DLAEVKAFAR ESLNLADLQP WDLGYASEKL REAKYAFSET 351EVKKYFPVGK VLNGLFAQIK KLYGIGFTEK TVPVWHKDVR YFELQQNGET 401IGGVYMDLYA REGKRGGAWM NDYKGRRRFS DGTLQLPTAY LVCNFAPPVG 451GREARLSHDE ILILFHETGH GLHHLLTQVD ELGVSGINGV EWDAVELPSQ 501FMENFVWEYN VLAQMSAHEE TGVPLPKELF DKMLAAKNFQ RGMFLVRQME 551FALFDMMIYS EDDEGRLKNW QQVLDSVRKK VAVIQPPEYN RFALSFGHIF 601AGGYSAGYYS YAWAEVLSAD AYAAFEESDD VAATGKRFWQ EILAVGGSRS 651AAESFKAFRG REPSIDALLR HSGFDNAV* m128-1/g128-194.5% identity in 491 aa overlap        10        20        30        40        50        60 g128-1.pepMIDNALLHLGEEPRFNQIKTEDIKPAVQTAIAEARGQIAAVKAQTHTGWANTVERLTGIT ||||||||||||||:||||||||||:|||||||| ||||:||||||||||||| ||||| m128-1MTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT        10        20        30        40        50        60        70        80        90       100       110       120 g128-1.pepERVGRIWGVVSHLNSVVDTPELRAVYNELMPEITVFFTEIGQDIELYNRFKLIKNSPEFA||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||| m128-1ERVGRIWGVVSHLNSVADTPELRAVYNELMPEITVFFTEIGQDIELYNRFKLIKNSPEFD        70        80        90       100       110       120       130       140       150       160       170       180 g128-1.pepTLSPAQKTKLDHDLRDFVLSGAELPPERQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY||||||||||:||||||||||||||||:|||||||||||||||||||||||||||||||| m128-1TLSPAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY       130       140       150       160       170       180       190       200       210       220       230       240 g128-1.pepFDDAAPLAGIPEDALAMFAAAAQSEGKTGYKIGLQIPHYLAVIQYAGNRELREQIYRAYV|||||||||||||||||||||||||:|||||||||||||||||||| ||||||||||||| m128-1FDDAAPLAGIPEDALAMFAAAAQSESKTGYKIGLQIPHYLAVIQYADNRELREQIYRAYV       190       200       210       220       230       240       250       260       270       280       290       300 g128-1.pepTRASELSNDGKEDNTANIDRTLENALKTAKLLGFKNYAELSLATKMADTPEQVLNFLHDL|||||||:|||||||||||||| |||:||||||||||||||||||||||||||||||||| m128-1TRASELSDDGKEDNTANIDRTLANALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDL       250       260       270       280       290       300       310       320       330       340       350       360 g128-1.pepARRAKPYAEKDLAEVKAFAREHLGLADPQPWDLSYAGEKLREAKYAFSETEVKKYFPVGK||||||||||||||||||||| |:||| |||||:||:||||||||||||||||||||||| m128-1ARRAKPYAEKDLAEVKAFARESLNLADLQPWDLGYASEKLREAKYAFSETEVKKYFPVGK       310       320       330       340       350       360       370       380       390       400       410       420 g128-1.pepVLAGLFAQIKKLYGIGFAEKTVPVWHKDVRYFELQQNGKTIGGVYMDLYAREGKRGGAWM ||||||||||||||||:||||||||||||||||||||:||||||||||||||||||||| m128-1VLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGETIGGVYMDLYAREGKRGGAWM       370       380       390       400       410       420       430       440       450       460       470       480 g128-1.pepNDYKGRRRFADGTLQLPTAYLVCNFAPPVGGKEARLSHDEILTLFHETGHGLHHLLTQVD|||||||||:|||||||||||||||||||||:|||||||||| ||||||||||||||||| m128-1NDYKGRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILILFHETGHGLHHLLTQVD       430       440       450       460       470       480        490g128-1.pep ELGVSGINGVK ||||||||||: m128-1ELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSAHEETGVPLPKELFDKMLAAKNFQ       490       500       510       520       530       540The following partial DNA sequence was identified in N. meningitidis<SEQ ID 491>:

a128-1.seq 1 ATGACTGACA ACGCACTGCT CCATTTGGGC GAAGAACCCC GTTTTGATCA 51AATCAAAACC GAAGACATCA AACCCGCCCT GCAAACCGCC ATTGCCGAAG 101CGCGCGAACA AATCGCCGCC ATCAAAGCCC AAACGCACAC CGGCTGGGCA 151AACACTGTCG AACCCCTGAC CGGCATCACC GAACGCGTCG GCAGGATTTG 201GGGCGTGGTG TCGCACCTCA ACTCCGTCAC CGACACGCCC GAACTGCGCG 251CCGCCTACAA TGAATTAATG CCCGAAATTA CCGTCTTCTT CACCGAAATC 301GGACAAGACA TCGAGCTGTA CAACCGCTTC AAAACCATCA AAAACTCCCC 351CGAGTTCGAC ACCCTCTCCC ACGCGCAAAA AACCAAACTC AACCACGATC 401TGCGCGATTT CGTCCTCAGC GGCGCGGAAC TGCCGCCCGA ACAGCAGGCA 451GAATTGGCAA AACTGCAAAC CGAAGGCGCG CAACTTTCCG CCAAATTCTC 501CCAAAACGTC CTAGACGCGA CCGACGCGTT CGGCATTTAC TTTGACGATG 551CCGCACCGCT TGCCGGCATT CCCGAAGACG CGCTCGCCAT GTTTGCCGCT 601GCCGCGCAAA GCGAAGGCAA AACAGGCTAC AAAATCGGTT TGCAGATTCC 651GCACTACCTC GCCGTCATCC AATACGCCGA CAACCGCAAA CTGCGCGAAC 701AAATCTACCG CGCCTACGTT ACCCGCGCCA GCGAGCTTTC AGACGACGGC 751AAATTCGACA ACACCGCCAA CATCGACCGC ACGCTCGAAA ACGCCCTGCA 801AACCGCCAAA CTGCTCGGCT TCAAAAACTA CGCCGAATTG TCGCTGGCAA 851CCAAAATGGC GGACACCCCC GAACAAGTTT TAAACTTCCT GCACGACCTC 901GCCCGCCGCG CCAAACCCTA CGCCGAAAAA GACCTCGCCG AAGTCAAAGC 951CTTCGCCCGC GAAAGCCTCG GCCTCGCCGA TTTGCAACCG TGGGACTTGG 1001GCTACGCCGG CGAAAAACTG CGCGAAGCCA AATACGCATT CAGCGAAACC 1051GAAGTCAAAA AATACTTCCC CGTCGGCAAA GTATTAAACG GACTGTTCGC 1101CCAAATCAAA AAACTCTACG GCATCGGATT TACCGAAAAA ACCGTCCCCG 1151TCTGGCACAA AGACGTGCGC TATTTTGAAT TGCAACAAAA CGGCGAAACC 1201ATAGGCGGCG TTTATATGGA TTTGTACGCA CGCGAAGGCA AACGCGGCGG 1251CGCGTGGATG AACGACTACA AAGGCCGCCG CCGTTTTTCA GACGGCACGC 1301TGCAACTGCC CACCGCCTAC CTCGTCTGCA ACTTCACCCC GCCCGTCGGC 1351GGCAAAGAAG CCCGCTTGAG CCATGACGAA ATCCTCACCC TCTTCCACGA 1401AACCGGACAC GGCCTGCACC ACCTGCTTAC CCAAGTCGAC GAACTGGGCG 1451TATCCGGCAT CAACGGCGTA GAATGGGACG CAGTCGAACT GCCCAGTCAG 1501TTTATGGAAA ATTTCGTTTG GGAATACAAT GTCTTGGCGC AAATGTCCGC 1551CCACGAAGAA ACCGGCGTTC CCCTGCCGAA AGAACTCTTC GACAAAATGC 1601TCGCCGCCAA AAACTTCCAA CGCGGAATGT TCCTCGTCCG CCAAATGGAG 1651TTCGCCCTCT TTGATATGAT GATTTACAGC GAAGACGACG AAGGCCGTCT 1701GAAAAACTGG CAACAGGTTT TAGACAGCGT GCGCAAAGAA GTCGCCGTCG 1751TCCGACCGCC CGAATACAAC CGCTTCGCCA ACAGCTTCGG CCACATCTTC 1801GCAGGCGGCT ATTCCGCAGG CTATTACAGC TACGCGTGGG CGGAAGTATT 1851GAGCGCGGAC GCATACGCCG CCTTTGAAGA AAGCGACGAT GTCGCCGCCA 1901CAGGCAAACG CTTTTGGCAG GAAATCCTCG CCGTCGGCGG ATCGCGCAGC 1951GCGGCAGAAT CCTTCAAAGC CTTCCGCGGA CGCGAACCGA GCATAGACGC 2001ACTCTTGCGC CACAGCGGCT TCGACAACGC GGCTTGAThis corresponds to the amino acid sequence <SEQ ID 492; ORF 128-1.a>:

a128-1.pep 1 MTDNALLHLG EEPRFDQIKT EDIKPALQTA IAEAREQIAA IKAQTHTGWA 51NTVEPLTGIT ERVGRIWGVV SHLNSVTDTP ELRAAYNELM PEITVFFTEI 101GQDIELYNRF KTIKNSPEFD TLSHAQKTKL NHDLRDFVLS GAELPPEQQA 151ELAKLQTEGA QLSAKFSQNV LDATDAFGIY FDDAAPLAGI PEDALAMFAA 201AAQSEGKTGY KIGLQIPHYL AVIQYADNRK LREQIYRAYV TRASELSDDG 251KFDNTANIDR TLENALQTAK LLGFKNYAEL SLATKMADTP EQVLNFLHDL 301ARRAKPYAEK DLAEVKAFAR ESLGLADLQP WDLGYAGEKL REAKYAFSET 351EVKKYFPVGK VLNGLFAQIK KLYGIGFTEK TVPVWHKDVR YFELQQNGET 401IGGVYMDLYA REGKRGGAWM NDYKGRRRFS DGTLQLPTAY LVCNFTPPVG 451GKEARLSHDE ILTLFHETGH GLHHLLTQVD ELGVSGINGV EWDAVELPSQ 501FMENFVWEYN VLAQMSAHEE TGVPLPKELF DKMLAAKNFQ RGMFLVRQME 551FALFDMMIYS EDDEGRLKNW QQVLDSVRKE VAVVRPPEYN RFANSFGHIF 601AGGYSAGYYS YAWAEVLSAD AYAAFEESDD VAATGKRFWQ EILAVGGSRS 651AAESFKAFRG REPSIDALLR HSGFDNAA* m128-1/a128-197.8% identity in 677 aa overlap        10        20        30        40        50        60 a128-1.pepMTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m128-1MTDNALLHLGEEPRFDQIKTEDIKPALQTAIAEAREQIAAIKAQTHTGWANTVEPLTGIT        10        20        30        40        50        60        70        80        90       100       110       120 a128-1.pepERVGRIWGVVSHLNSVTDTPELRAAYNELMPEITVFFTEIGQDIELYNRFKLIKNSPEFD||||||||||||||||:|||||||:||||||||||||||||||||||||||||||||||| m128-1ERVGRIWGVVSHLNSVADTPELRAVYNELMPEITVFFTEIGQDIELYNRFKLIKNSPEFD        70        80        90       100       110       120       130       140       150       160       170       180 a128-1.pepTLSHAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m128-1TLSPAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGAQLSAKFSQNVLDATDAFGIY       130       140       150       160       170       180       190       200       210       220       230       240 a128-1.pepFDDAAPLAGIPEDALAMFAAAAQSEGKTGYKIGLQIPHYLAVIQYADNRKLREQIYRAYV|||||||||||||||||||||||||:|||||||||||||||||||||||:|||||||||| m128-1FDDAAPLAGIPEDALAMFAAAAQSESKTGYKIGLQIPHYLAVIQYADNRELREQIYRAYV       190       200       210       220       230       240       250       260       270       280       290       300 a128-1.pepTRASELSDDGKEDNTANIDRTLENALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDL|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| m128-1TRASELSDDGKEDNTANIDRTLANALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDL       250       260       270       280       290       300       310       320       330       340       350       360 a128-1.pepARRAKPYAEKDLAEVKAFARESLGLADLQPWDLGYAGEKLREAKYAFSETEVKKYFPVGK|||||||||||||||||||||||:||||||||||||:||||||||||||||||||||||| m128-1ARRAKPYAEKDLAEVKAFARESLNLADLQPWDLGYASEKLREAKYAFSETEVKKYFPVGK       310       320       330       340       350       360       370       380       390       400       410       420 a128-1.pepVLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGETIGGVYMDLYAREGKRGGAWM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m128-1VLNGLFAQIKKLYGIGFTEKTVPVWHKDVRYFELQQNGETIGGVYMDLYAREGKRGGAWM       370       380       390       400       410       420       430       440       450       460       470       480 a128-1.pepNDYKGRRRFSDGTLQLPTAYLVCNFTPPVGGKEARLSHDEILTLFHETGHGLHHLLTQVD|||||||||||||||||||||||||:|||||:|||||||||| ||||||||||||||||| m128-1NDYKGRRRFSDGTLQLPTAYLVCNFAPPVGGREARLSHDEILILFHETGHGLHHLLTQVD       430       440       450       460       470       480       490       500       510       520       530       540 a128-1.pepELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSAHEETGVPLPKELFDKMLAAKNFQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m128-1ELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSAHEETGVPLPKELFDKMLAAKNFQ       490       500       510       520       530       540       550       560       570       580       590       600 a128-1.pepRGMFLVRQMEFALFDMMIYSEDDEGRLKNWQQVLDSVRKEVAVVRPPEYNRFANSFGHIF|||||||||||||||||||||||||||||||||||||||:|||::|||||||| |||||| m128-1RGMFLVRQMEFALFDMMIYSEDDEGRLKNWQQVLDSVRKKVAVIQPPEYNRFALSFGHIF       550       560       570       580       590       600       610       620       630       640       650       660 a128-1.pepAGGYSAGYYSYAWAEVLSADAYAAFEESDDVAATGKRFWQEILAVGGSRSAAESFKAFRG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m128-1AGGYSAGYYSYAWAEVLSADAYAAFEESDDVAATGKRFWQEILAVGGSRSAAESFKAFRG       610       620       630       640       650       660       670      679 a128-1.pep REPSIDALLRHSGFDNAAX |||||||||||||||||:m128-1 REPSIDALLRHSGFDNAVX        670 a128-1/P44573sp|P44573|OPDA_HAEIN OLIGOPEPTIDASE A >gi|1075082|pir||O64055oligopeptidase A (prlC) homolog - Haemophilus influenzae (strain Rd KW20)>gi|1573174 (U32706) oligopeptidase A (prlC) [Haemophilus influenzae Rd]Length = 681 Score = 591 bits (1507), Expect = e−168 Identities =309/677 (45%), Positives = 415/677 (60%), Gaps = 4/677 (0%) Query: 4NALLHLGEEPRFDQIKTEDIKPALQTXXXXXXXXXXXXXXXTHTGWANTVEPLTGITERV 63 N LL++  P F QIK E I+PA++                 H  W N + PLT   +R+ Sbjct: 5NPLLNIQGLPPFSQIKPEHIRPAVEKLIQDCRNTIEQVLKQPHFTWENFILPLTETNDRL 64 Query:64 GRIWGVVSHLNSVTDTPELRAAYNELMPEITVFFTEIGQDIELYNRFKTIKNSPEFDTLS 123 R W  VSHLNSV ++ ELR AY   +P ++ + T +GQ   LYN +  +KNS EF   S Sbjct: 65NRAWSPVSHLNSVKNSTELREAYQTCLPLLSEYSTWVGQHKGLYNAYLALKNSAEFADYS 124 Query:124 HAQKTKLNHDLRDFVLSGAELPPEQQAELAKLQTEGAQLSAKFSQNVLDATDAFGIYFDD 183 AQK  + + LRDF LSG  L  E+Q    ++    ++L+++FS NVLDAT  +    ++ Sbjct: 125IAQKKAIENSLRDFELSGIGLSEEKQQRYGEIVARLSELNSQFSNNVLDATMGWEKLIEN 184 Query:184 AAPLAGIPEDALAMFAAAAQSEGKTGYKIGLQIPHYLAVIQYADNRKLREQTYRAYVTRA 243 A LAG+PE AL     +A+S+G  GY+  L+IP YL V+ Y +NR LRE++YRAY TRA Sbjct: 185EAELAGLPESALQAAQQSAESKGLKGYRFTLEIPSYLPVMTYCENRALREEMYRAYATRA 244 Query:244 SELSDD-GKFDNTANIDRTLENALQTAKLLGFKNYAELSLATKMADTPEQVLNFLHDLAR 302SE   + GK+DN+  ++  L   ++ AKLLGF  Y ELSLATKMA+ P+QVL+FL  LA Sbjct: 245SEQGPNAGKWDNSKVMEEILTLRVELAKLLGFNTYTELSLATKMAENPQQVLDFLDHLAE 304 Query:303 RAKPYAEKDLAEVKAFARESLGLADLQPWDLGYAGEKLREAKYAFSETEVKKYFPVGKVL 362RAKP  EK+L E+K +  +  G+ +L PWD+G+  EK ++  YA ++ E++ YFP  +V+ Sbjct: 305RAKPQGEKELQELKGYCEKEFGVTELAPWDIGFYSEKQKQHLYAINDEELRPYFPENRVI 364 Query:363 NGLFAQIKKLYGIGFTE-KTVPVWHKDVRYFEL-QQNGETIGGVYMDLYAREGKRGGAWM 420+GLF  IK+++ I   E K V  WHKDVR+F+L  +N +  G  Y+DLYARE KRGGAWM Sbjct: 365SGLFELIKRIFNIRAVERKGVDTWHKDVRFFDLIDENDQLRGSFYLDLYAREHKRGGAWM 424 Query:421 NDYKGRRRFSDGTLQLPTAYLVCNFTPPVGGKEARLSHDEIXXXXXXXXXXXXXXXXQVD 480+D  GR+R  DG+++ P AYL CNF  P+G K A  +H+E+                Q+D Sbjct: 425DDCIGRKRKLDGSIETPVAYLTCNFNAPIGNKPALFTHNEVTTLFHEFGHGIHHMLTQID 484 Query:481 ELGVSGINGVEWDAVELPSQFMENFVWEYNVLAQMSAHEETGVPLPKELFDKMLAAKNFQ 540   V+GINGV WDAVELPSQFMEN+ WE   LA +S H ETG PLPKE   ++L AKNFQ Sbjct: 485VSDVAGINGVPWDAVELPSQFMENWCWEEEALAFISGHYETGEPLPKEKLTQLLKAKNFQ 544 Query:541 RGMFLVRQMEFALFDMMIYSEDDEGRLKNWQQVLDSVRKEVAVVRPPEYNRFANSFGHIF 600  MF++RQ+EF +FD  ++   D  +       L SV+ +VAV++  ++ R  +SF HIF Sbjct: 545AAMFILRQLEFGIFDFRLHHTFDAEKTNQILDTLKSVKSQVAVIKGVDWARAPHSFSHIF 604 Query:601 XXXXXXXXXXXXWAEVLSADAYAAFEESDDV-AATGKRFWQEILAVGGSRSAAESFKAFR 659            WAEVLSADAY+ FEE       TGK F  EIL  GGS    E FK FR Sbjct: 605AGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNPITGKSFLDEILTRGGSEEPMELFKRFR 664 Query:660 GREPSIDALLRHSGFDN 676 GREP +DALLRH G  N Sbjct: 665 GREPQLDALLRHKGIMN681The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 493>:

g129.seq 1 ATGCTTTCAC CTCCTCGGCG TAAAACGGCG GCACATCAAT CAAGCCGTCT 51TTCATTTGCG TGCGGAAAAA ATGCGGCGTG TTGCCGTGAT CAAAATCAAT 101ATCGTGCAGC ATCCAGCCCA AATCGCGGTT TGCCTCGCTT TCCGATAACG 151CCGACGGCGG CAGCGGTTCA CCCTTATCCG CGCTTTCGCC ATTTGCCCTT 201TCAGGCTGCG GGCATAGGGG CGGAACAGGC GGCGGTCGAA TCCTGTTTCA 251TCCGGACAAA CGCGTTGGCA GTCGGAAAAT CCGGCCGGCC GTGTCAAATA 301ATGCGTTACT TTGGCCGGGT CTTGTCCTTT GTAAGCGGCG GTCTTTTTTT 351GCGCGCCATC CGCATCTGTT TGGGCGCATG GCAAACGGCG GCTGCCGTAC 401AATCAAAATG TTTGGCGATT TCATGCAGAC AGGCATCCGG ATGCCGCCCG 451ACATATCGAG CCGGTTTTTG CCTATCCGAT TTGGCGGCAT TTAGGCCGGT 501 AACTTGAThis corresponds to the amino acid sequence <SEQ ID 494; ORF 129.ng>:

g129.pep 1 MLSPPRRKTA AHQSSRLSFA CGKNAACCRD QNQYRAASSP NRGLPRFPIT 51PTAAAVHPYP RFRHLPFQAA GIGAEQAAVE SCFIRTNALA VGKSGRPCQI 101MRYFGRVLSF VSGGLFLRAI RICLGAWQTA AAVQSKCLAI SCRQASGCRP 151TYRAGFCLSD LAAFRPVT*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 495>:

m129.seq (partial) 1..TATCTGCGCT TTCACTATTT GCCCTTTCAG GCTGCGGGCA TAGGGACGGA 51  ACAGGTAGCG GTCAAATCCT GTTTCATCCA AATAAACACG TTGGTAGTCG 101  GAAAATTCGG CCGGCTGTGT CAAATAATGC GTTACTTTGG CCGGGTCTTG 151  TTCTTTGTAA GTGGTGGTCT TTTTTTGCGC GTTATCCCCA TCTGTTTGAG 201  TGCATAGCAA ATGGTGGCTG CCGTACAATC AAAATGTTTG GCGATTTCAT 251  GCAGATAGGC ATCCGGGTGT TGCCCAACAT ATTGAGCCGG TTTTTGCCTA 301  TCCGATTTGA CGGCATTTAG ACCGGTAACT TGAThis corresponds to the amino acid sequence <SEQ ID 496; ORF 129>:

m129.pep (partial) 1..YLRFHYLPFQ AAGIGTEQVA VKSCFIQINT LVVGKFGRLC QIMRYFGRVL 51  FFVSGGLFLR VIPICLSAXQ MVAAVQSKCL AISCRXASGC CPTYXAGFCL 101  SDLTAFRPVT *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 129 shows 79.1% identity over a 110 aa overlap with a predicted ORF(ORF 129.ng) from N. gonorrhoeae:

m129/g129                                        10        20        30m129.pep                                YLRFHYLPFQAAGIGTEQVAVKSCFIQINT                               | ||::|||||||||:||:||:||||: |: g129 RDQNQYRAASSPNRGLPRFPITPTAAAVHPYPRFRHLPFQAAGIGAEQAAVESCFIRTNA 30        40        50        60        70        80         40        50        60        70        80        90 m129.pep LVVGKFGRLCQIMRYFGRVLFFVSGGLFLRVIPICLSAXQMVAAVQSKCLAISCRXASGC  |:||| ||||||||||||| |||||||||:| |||:| | :||||||||||||| |||| g129 LAVGKSGRPCQIMRYFGRVLSFVSGGLFLRAIRICLGAWQTAAAVQSKCLAISCRQASGC 90       100       110       120       130       140        100       110 m129.pep  CPTYXAGFCLSDLTAFRPVTX   |||||||||||:||||||| g129  RPTYRAGFCLSDLAAFRPVTX 150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 497>:

a129.seq (partial) 1TATCTGCGCT TTCACTATTT GCCCTTTCAG GCTGCGGGCA TAGGGACGGA 51ACAGGTAGCG GTCAAATCCT GTTTCATCCA AATAAACACG TTGGTAGTCG 101GAAAATTCGG CCAGCTGTGT CAAATAATGC GTTACTTTGG CCGGGTCTTG 151TTCTTTGTAA GTGGTGGTCT TTTTTTGCGC GTTATCCCCA TCTGTTTGAG 201TGCATAGCAA ATGGTGGCTG CCGTACAATC AAAATGTTTG GCGATTTCAT 251GCAGATAGGC ATCCTGGTGT TGCCCAACAT ATTGAGCCGG TTTTTGCCTA 301TCCGATTTGA CGGCATTTAG ACCGGTAACT TGAThis corresponds to the amino acid sequence <SEQ ID 498; ORF 129.a>:

a129.pep (partial) 1YLRFHYLPFQ AAGIGTEQVA VKSCFIQINT LVVGKFGQLC QIMRYFGRVL 51FFVSGGLFLR VIPICLSA*Q MVAAVQSKCL AISCR*ASWC CPTY*AGFCL 101 SDLTAFRPVT *m129/a129 98.2% identity in 110 aa overlap        10        20        30        40        50        60 m129.pepYLRFHYLPFQAAGIGTEQVAVKSCFIQINTLVVGKFGRLCQIMRYFGRVLFFVSGGLFLR|||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||| a129YLRFHYLPFQAAGIGTEQVAVKSCFIQINTLVVGKFGQLCQIMRYFGRVLFFVSGGLFLR        10        20        30        40        50        60        70        80        90       100       110 m129.pepVIPICLSAXQMVAAVQSKCLAISCRXASGCCPTYXAGFCLSDLTAFRPVTX|||||||||||||||||||||||||||| |||||||||||||||||||||| a129VIPICLSAXQMVAAVQSKCLAISCRXASWCCPTYXAGFCLSDLTAFRPVTX        70        80        90       100       110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 499>:

g130.seq 1 ATGAAACAAC TCCGCGACAA CAAAGCCCAA GGCTCTGCAC TGTTTACCCT 51TGTGAGCGGT ATCGTTATTG TTATTGCAGT CCTTTATTTC CTGATTAAGC 101TGGCGGGCAG TGGATCGTTC GGCGATGTCG ATGCCACTAC GGAAGCGGCA 151ACGCAGACCC GCATCCAGCC TGTCGGACAA TTGACGATGG GTGACGGCAT 201CCCCGTCGGC GAACGCCAAG GCGAACAGAT TTTCGGCAAA ATCTGTATCC 251AATGCCACGC GGCGGACAGC AATGTGCCGA ACGCTCCGAA ACTGGAACAC 301AACGGCGACT GGGCGCCGCG TATCGCGCAA GGCTTCGATA CCTTGTTCCA 351ACACGCGCTG AACGGCTTTA ACGCCATGCC TGCCAAAGGC GGTGCGGCAG 401ACCTGACCGA TCAGGAACTC AAACGGGCGA TTACCTACAT GGCGAATAAA 451AGCGGCGGTT CTTTCCCGAA TCCTGATGAG GCTGCGCCTG CCGACAATGC 501CGCTTCAGGA ACAGCTTCTG CTCCTGCCGA TAGTGCAGCT CCGGCAGAAG 551CGAAGGCAGA AGACAAGGGT GCGGCAGCCC CTGCGGTCGG CGTTGACGGT 601AAAAAAGTCT TCGAAGCAAC CTGTCAGGTG TGCCACGGCG GTTCGATTCC 651CGGTATTCCC GGCATAGGCA AAAAAGACGA TTGGGCACCG CGTATCAAAA 701AAGGCAAAGA AACCTTGCAC AAACATGCCC TTGAAGGCTT TAACGCGATG 751CCGGCCAAAG GCGGCAATGC AGGTTTGAGC GATGACGAAG TCAAAGCGGC 801TGTTGACTAT ATGGCAAACC AATCCGGTGC AAAATTCTAAThis corresponds to the amino acid sequence <SEQ ID 500; ORF 130.ng>:

g130.pep 1 MKQLRDNKAQ GSALFTLVSG IVIVIAVLYF LIKLAGSGSF GDVDATTEAA 51TQTRIQPVGQ LTMGDGIPVG ERQGEQIFGK ICIQCHAADS NVPNAPKLEH 101NGDWAPRIAQ GFDTLFQHAL NGFNAMPAKG GAADLTDQEL KRAITYMANK 151SGGSFPNPDE AAPADNAASG TASAPADSAA PAEAKAEDKG AAAPAVGVDG 201KKVFEATCQV CHGGSIPGIP GIGKKDDWAP RIKKGKETLH KHALEGFNAM 251PAKGGNAGLS DDEVKAAVDY MANQSGAKF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 501>:

m130.seq (partial) 1..GGCGAACAGA TTTTCGGCAA AATCTGTATC CAATGCCACG CGGCGGACAG 51  CAATGTGCCG AACGCTCCGA AACTGGAACA CAACGGCGAT TrGGCACCGC 101  GTATCGgCAA GGCTTCGATA CCTTGTTCCA ACACGCGCTG AACGGCTTTA 151  ACGCCATGCC TGCAAAAGGC GGTGCGGCAG ACCTGACCGA TCAGGAACTT 201  AAACGGGCGA TTACTTACAT GGCGAACAAA AGCGGCGGTT CTTTCCCGAA 251  TCCTGATGAG GCTGCGCCTG CCGACAATGC CGCTTCAGGA ACAGCTTCTG 301  CTCCTGCCGA TAGTGCAGCT CCGGCAGAAG CGAAGGCAGA AGACAAGGGT 351  GCGGCAcCCC TGCGGTCGGC GTTGACGGTA AAAAAGTCTT CGAAGCAACC 401  TGTCAGGTGT GCCACGGCGG TTCGATTCCC GGTATTCCCG GCATAGGCAA 451  AAAAGACGAT TGGGCACCGC GTATCAAAAA AGGCAAAGAA ACCTTGCACA 501  AACACGCCCT TGAAGGCTTT AACGCGATGC CTGCCAAArG CGgCAATGCA 551  GGTTTGAGCG ATGACGAAgT CAAAGCGGCT GTTGACTATA TGGCAAACCA 601  ATCCGGTGCA AAATTCTAAThis corresponds to the amino acid sequence <SEQ ID 502; ORF 130>:

m130.pep (partial) 1..GEQIFGKICI QCHAADSNVP NAPKLEHNGD XAPRIQGFDT LFQHALNGFN 51  AMPAKGGAAD LTDQELKRAI TYMANKSGGS FPNPDEAAPA DNAASGTASA 101  PADSAAPAEA KAEDKGAAPA VGVDGKKVFE ATCQVCHGGS IPGIPGIGKK 151  DDWAPRIKKG KETLHKHALE GFNAMPAKXG NAGLSDDEVK AAVDYMANQS 201   GAKF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 130 shows 98.1% identity over a 206 aa overlap with a predicted ORF(ORF 130.ng) from N. gonorrhoeae:

m130/g130                                        10        20        30m130.pep                                GEQIFGKICIQCHAADSNVPNAPKLEHNGD                               |||||||||||||||||||||||||||||| g130 DATTEAATQTRIQPVGQLTMGDGIPVGERQGEQIFGKICIQCHAADSNVPNAPKLEHNGD      50        60        70        80        90        100          40        50        60        70        80       89 m130.pep XAPRI-QGFDTLFQHALNGFNAMPAKGGAADLTDQELKRAITYMANKSGGSFPNPDEAAP   |||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g130 WAPRIAQGFDTLFQHALNGFNAMPAKGGAADLTDQELKRAITYMANKSGGSFPNPDEAAP     110       120       130       140       150       16090       100       110        120       130       140 m130.pep ADNAASGTASAPADSAAPAEAKAEDKGAA-PAVGVDGKKVFEATCQVCHGGSIPGIPGIG ||||||||||||||||||||||||||||| |||||||||||||||||||||||||||||| g130 ADNAASGTASAPADSAAPAEAKAEDKGAAAPAVGVDGKKVFEATCQVCHGGSIPGIPGIG     170       180       190       200       210       220150       160       170       180       190       200 m130.pep KKDDWAPRIKKGKETLHKHALEGFNAMPAKXGNAGLSDDEVKAAVDYMANQSGAKFX |||||||||||||||||||||||||||||| |||||||||||||||||||||||||| g130 KKDDWAPRIKKGKETLHKHALEGFNAMPAKGGNAGLSDDEVKAAVDYMANQSGAKFX     230       240       250       260       270       280The following partial DNA sequence was identified in N. meningitidis<SEQ ID 503>:

a130.seq 1 ATGAAACAAC TCCGCGACAA CAAAGCCCAA GGCTCTGCAC TGTTTACCCT 51TGTGAGCGGT ATCGTTATTG TTATTGCAGT CCTTTATTTC CTGATTAAGC 101TGGCGGGCAG CGGCTCGTTC GGCGATGTCG ATGCCACTAC GGAAGCAGCA 151ACGCAGACCC GTATCCAGCC TGTCGGACAA TTGACGATGG GCGACGGCAT 201CCCCGTCGGC GAACGCCAAG GCGAACAGAT TTTCGGCAAA ATCTGTATCC 251AATGCCACGC GGCGGACAGC AATGTGCCGA ACGCTCCGAA ACTGGAACAC 301AACGGCGATT GGGCGCCGCG TATCGCGCAA GGCTTCGATA CCTTGTTCCA 351ACACGCGCTG AACGGCTTTA ACGCCATGCC TGCCAAAGGC GGTGCGGTAG 401ACCTGACCGA TCAGGAACTC AAACGGGCGA TTACTTACAT GGCGAACAAA 451AGCGGCGGTT CTTTCCCGAA TCCTGATGAG GCTGCGCCTG CCGACAATGC 501CGCTTCAGGA ACAGCTTCTG CTCCTGCCGA TAGTGCAGCT CCGGCAGAAG 551CGAAGGCAGA AGACAAGGGT GCGGCAGCCC CTGCGGTCGG CGTTGACGGT 601AAAAAAGTCT TCGAAGCAAC CTGTCAGGTG TGCCACGGCG GTTCGATTCC 651CGGTATTCCC GGCATAGGCA AAAAAGACGA TTGGGCACCG CGTATCAAAA 701AAGGCAAAGA AACCTTGCAC AAACACGCCC TTGAAGGCTT TAACGCGATG 751CCTGCCAAAG GCGGCAATGC AGGTTTGAGC GATGACGAAG TCAAAGCGGC 801TGTTGACTAT ATGGCAAACC AATCCGGTGC AAAATTCTAAThis corresponds to the amino acid sequence <SEQ ID 504; ORF 130.a>:

a130.pep 1 MKQLRDNKAQ GSALFTLVSG IVIVIAVLYF LIKLAGSGSF GDVDATTEAA 51TQTRIQPVGQ LTMGDGIPVG ERQGEQIFGK ICIQCHAADS NVPNAPKLEH 101NGDWAPRIAQ GFDTLFQHAL NGFNAMPAKG GAVDLTDQEL KRAITYMANK 151SGGSFPNPDE AAPADNAASG TASAPADSAA PAEAKAEDKG AAAPAVGVDG 201KKVFEATCQV CHGGSIPGIP GIGKKDDWAP RIKKGKETLH KHALEGFNAM 251PAKGGNAGLS DDEVKAAVDY MANQSGAKF* m130/a13097.6% identity in 206 aa overlap                                       10        20        30 m130.pep                               GEQIFGKICIQCHAADSNVPNAPKLEHNGD                               |||||||||||||||||||||||||||||| a130 DATTEAATQTRIQPVGQLTMGDGIPVGERQGEQIFGKICIQCHAADSNVPNAPKLEHNGD      50        60        70        80        90       100          40        50        60        70        80       89 m130.pep XAPRI-QGFDTLFQHALNGFNAMPAKGGAADLTDQELKRAITYMANKSGGSFPNPDEAAP   |||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| a130 WAPRIAQGFDTLFQHALNGFNAMPAKGGAVDLTDQELKRAITYMANKSGGSFPNPDEAAP     110       120       130       140       150       16090       100       110        120       130       140 m130.pep ADNAASGTASAPADSAAPAEAKAEDKGAA-PAVGVDGKKVFEATCQVCHGGSIPGIPGIG ||||||||||||||||||||||||||||| |||||||||||||||||||||||||||||| a130 ADNAASGTASAPADSAAPAEAKAEDKGAAAPAVGVDGKKVFEATCQVCHGGSIPGIPGIG     170       180       190       200       210       220150       160       170       180       190       200 m130.pep KKDDWAPRIKKGKETLHKHALEGFNAMPAKXGNAGLSDDEVKAAVDYMANQSGAKFX |||||||||||||||||||||||||||||| |||||||||||||||||||||||||| a130 KKDDWAPRIKKGKETLHKHALEGFNAMPAKGGNAGLSDDEVKAAVDYMANQSGAKFX     230       240       250       260       270       280The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 505>:

g132.seq 1 ATGGAAGCCT TCAAAACCCT AATTTGGATT ATTAATATTA TTTCCGCTTT 51GGCCGTCATC GTGTTAGTAT TGCTCCAACA CGGCAAAGGC GCGGATGCCG 101GCGCGACCTT CGGATCGGGA AGCGGCAGCG CGCAAGGCGT ATTCGGCTCT 151GCCGGCAACG CCAACTTcct CAgccGCTCG AccGccGTTG CAGCAACAtt 201tttcttTGca acctgcAtgg gctatggTgt atattcacac CCACACGACA 251AAACACGGTT TGGACTtcag caacataCGA CAGACTCAGC AagcACCCAA 301ACCcgtAAGC AATACCGAAC CTTCTGCCCC TGTTCCTCAG CAGCAGAAAT 351AACagtTTTT CAAATgccga caTGgtgaThis corresponds to the amino acid sequence <SEQ ID 506; ORF 132.ng>:

g132.pep 1 MEAFKTLIWI INIISALAVI VLVLLQHGKG ADAGATFGSG SGSAQGVFGS 51AGNANFLSRS TAVAATFFFA TCMGYGVYSH PHDKTRFGLQ QHTTDSASTQ 101TRKQYRTFCP CSSAAEITVF QMPTW*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 507>:

m132.seq (partial) 1ATGGAACCCT TCAAAACCTT AATTTGGATT GTTAATTTAA TTTCCGCTTT 51GGCCGTCTTC GTGTTAGTAT TGCTCCAACA CGGCAAAGGC GCGGATGCCG 101GCGCGACTTT CGGA...This corresponds to the amino acid sequence <SEQ ID 508; ORF 132>:

m132.pep (partial) 1 MEPFKTLIWI VNLISALAVF VLVLLQHGKG ADAGATFG...Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 132 shows 89.5% identity over a 38 aa overlap with a predicted ORF(ORF 132.ng) from N. gonorrhoeae:

m132/g132         10        20        30 m132.pepMEPFKTLIWIVNLISALAVFVLVLLQHGKGADAGATFG|| |||||||:|:||||||:|||||||||||||||||| g132MEAFKTLIWIINIISALAVIVLVLLQHGKGADAGATFGSGSGSAQGVFGSAGNANFLSRS        10        20        30        40        50        60The following partial DNA sequence was identified in N. meningitidis<SEQ ID 509>:

a132.seq 1 ATGGAAGCCT TCAAAACCCT AATTTGGATT GTTAATATAA TTTCCGCTTT 51GGCCGTCATC GTGTTAGTAT TGCTCCAACA CGGCAAAGGC GCGGATGCCG 101 GCGCGACTTTCGGATCGGGA AGCGGCAGCG CGCAAGGCGT ATTCGGCTCT 151 GCCGGCAACG CTAACTTCCTCAGCCGCTCG ACCGCCGTTG CAGCAACATT 201 TTTCTTTGCA ACCTGCATGg GCTATGGTGTATATTCACAC CCACACGACA 251 AAACACGGTT TGGACTTCAG CAACGTACAA CAAACTCAGCAAGCACCCAA 301 ACCCGTAAGC AATACCGAAC CTTCTGCCCC TGTTCCTCAG CAGCAGAAAT351 AACAGTTTTT CAAATGCCGA CATGGTGAThis corresponds to the amino acid sequence <SEQ ID 510; ORF 132.a>:

a132.pep 1 MEAFKTLIWI VNIISALAVI VLVLLQHGKG ADAGATFGSG SGSAQGVFGS 51AGNANFLSRS TAVAATFFFA TCMGYGVYSH PHDKTRFGLQ QRTTNSASTQ 101 TRKQYRTFCPCSSAAEITVF QMPTW* m132/a132 92.1% identity in 38 aa overlap        10        20        30 m132.pepMEPFKTLIWIVNLISALAVFVLVLLQHGKGADAGATFG|| |||||||||:||||||:|||||||||||||||||| a132MEAFKTLIWIVNIISALAVIVLVLLQHGKGADAGATFGSGSGSAQGVFGSAGNANFLSRS        10        20        30        40        50        60The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 511>:

g134.seq 1 ATGTCCCAAG AAATCCTCGA CCAAGTGCGC CGCCGCCGCA CGTTTGCCAT 51CATCTCCCAC CCCGATGCGG GTAAAACCAC GCTGACCGAA AAACTGCTGC 101 TGTTTTCGGGCGCGATTCAA AGCGCAGGCA CGGTGAAAGG TAAGAAAACC 151 GGCAAATTCG CCACCTCCGACTGGATGGAC ATCGAGAAGC AGCGCGGCAT 201 TTCCGTGGCA TCAAGCGTGA TGCAGTTCGACTACAAAGAC CACACCGTCA 251 ACCTCTTGGA CACGCCGGGA CACCAAGACT TCTCCGAAGACACCTACCGC 301 GTTTTAACCG CAGTGGACAG CGCCTTGATG GTCATCGACG CGGCAAAAGG351 CGTGGAAGCG CAAACCATCA AACTCTTGAA CGTCTGCCGC CTGCGCGATA 401CGCCGATTGT TACCTTCATG AACAAATACG ACCGCGAAGT GCGCGATTCT 451 TTGGAACTCTTGGACGAAGT GGAAGACATC CTGCAAATCC GCTGCGCGCC 501 CGTTACCTGG CCGATCGGTATGGGCAAAAA CTTCAAGGGC GTGTACCACA 551 TCCTGAACGA CGAAATCTAT CTCTTTGAAGCGGGCGGCGA ACGCCTGCCG 601 CACGAGTTCG ACATCATCAA AGGCATAAAC AATCCCGAATTGGAACAACG 651 CTTTCCGTTG GAAATCCAGC AGTTGCGCGA CGAAATCGAA TTGGTGCAGG701 CGGCTTCCAA CGAATTTAAT CTCGacgaAT TTCTCGccgG CGAACTCACG 751CCAGTGTTCT TCGGCTCTGC GATTAACAAC TTCGGCATTC AGGAAATCCT 801 CAATTCATTGATTGACTGGG CACCCGCACC GAAACCGCGC GACGCGACCA 851 TGCGCATGGT CGGGCCGGACGAGCCGAAAT TTTCCGGATT TATCTTTAAA 901 ATCCAAGCCA ATATGGACCC GAAACACCGCGACCGTATCG CCTTCTTGCG 951 CGTCTGCTCC GGTAAATTCG AGCGCGGCAT GAAGATGAAACACCTGCGTA 1001 TCAACCGCGA AATCGCCGCC TCCAGCGTAG TAACCTTCAT GTCGCACGAC1051 CGCGAACTGG CGGAAGAAGC CTACGCCGGC GACATCATCG GCATCCCGAA 1101CCACGGCAAC ATCCAAATCG GCGACAGCTT CTCCGAAGGC GAACAACTGG 1151 CGTTTACCGGCATCCCATTC TTCGCGCCCG AACTGTTCCG CAGCGTCCGC 1201 ATCAAAAACC CGCTGAAAATCAAACAACTG CAAAAAGGTT TGCAACAACT 1251 CGGCGAAGAA GGTGCGGTTC AAGTATTCAAACCGATGAGC GGCGCGGATT 1301 TGATTTTGGG TGCGGTCGGC GTGTTGCAGT TTGAAGTCGTAACCTCACGC 1351 CTCGCCAACG AATACGGCGT GGAAGCCGTG TTCGACAGCG CATCCATCTG1401 GTCGGCGCGC TGGGTATCGT GCGACGACAA GAAAAAACTG GCGGAATTTG 1451AAAAAGCCAA CGCAGGCAAC CTCGCCATCG ACGCAGGCGG CAACCTCGCC 1501 TACCTCGCCCCCAACCGCGT GAATTTGGGG TTGACGCAAG AACGCTGGCC 1551 GGACATCGTG TTCCACGAAACGCGCGAACA TTCGGTCAAA CTCTAAThis corresponds to the amino acid sequence <SEQ ID 512; ORF 134.ng>:

g134.pep 1 MSQEILDQVR RRRTFAIISH PDAGKTTLTE KLLLFSGAIQ SAGTVKGKKT 51GKFATSDWMD IEKQRGISVA SSVMQFDYKD HTVNLLDTPG HQDFSEDTYR 101 VLTAVDSALMVIDAAKGVEA QTIKLLNVCR LRDTPIVTFM NKYDREVRDS 151 LELLDEVEDI LQIRCAPVTWPIGMGKNFKG VYHILNDEIY LFEAGGERLP 201 HEFDIIKGIN NPELEQRFPL EIQQLRDEIELVQAASNEFN LDEFLAGELT 251 PVFFGSAINN FGIQEILNSL IDWAPAPKPR DATMRMVGPDEPKFSGFIFK 301 IQANMDPKHR DRIAFLRVCS GKFERGMKMK HLRINREIAA SSVVTFMSHD351 RELAEEAYAG DIIGIPNHGN IQIGDSFSEG EQLAFTGIPF FAPELFRSVR 401IKNPLKIKQL QKGLQQLGEE GAVQVFKPMS GADLILGAVG VLQFEVVTSR 451 LANEYGVEAVFDSASIWSAR WVSCDDKKKL AEFEKANAGN LAIDAGGNLA 501 YLAPNRVNLG LTQERWPDIVFHETREHSVK L*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 513>:

m134.seq 1 ATGTCCCAAG AAATCCTCGA CCAAGTGCGC CGCCGCCGCA CGTTTGCCAT 51CATCTCCCAC CCTGACGCAG GTAAAACCAC GTTGACTGAA AAACTCTTGC 101 TGTTTTCGGGCGCGATTCAG AGCGCGGGTA CGGTAAAAGG CAAGAAAACC 151 GGCAAATTCG CCACTTCCGACTGGATGGAA ATCGAGAAGC AGCGCGGCAT 201 TTCCGTGGCA TCAAGTGTGA TGCAGTTCGATTACAAAGAC CACACCGTCA 251 ACCTCTTGGA CACGCCGGGA CACCAAGACT TCTCCGAAGACACCTACCGC 301 GTTTTAACCG CCGTGGACAG CGCATTAATG GTCATCGACG CGGCAAAAGG351 CGTGGAAGCG CAAACCATCA AGCTCTTAAA CGTCTGCCGC CTGCGCGATA 401CACCGATTGT TACGTTTATG AACAAATACG ACCGCGAAGT GCGCGATTCC 451 CTGGAACTTTTGGACGAAGT GGAAAACATT TTAAAAATCC GCTGCGCGCC 501 CGTTACCTGG CCGATCGGTATGGGCAAAAA CTTCAAGGGC GTGTACCACA 551 TCCTGAACGA TGAAATTTAT CTCTTTGAAGCTGGCGGCGA ACGCCTGCCG 601 CACGAGTTCG ACATCATCAA AGGCATCGAT AATCCTGAATTGGAACAACG 651 CTTTCCGTTG GAAATCCAGC AGTTGCGCGA CGAAATCGAA TTGGTGCAGG701 CGGCTTCCAA CGAGTTTAAT CTCGACGAAT TCCTCGCCGG CGAACTCACG 751CCCGTATTCT TCGGCTCTGC GATTAACAAC TTCGGTATTC AGGAAATCCT 801 CAATTCATTGATTGACTGGG CGCCCGCGCC GAAACCGCGC GACGCGACCG 851 TACGTATGGT CGAGCCGGACGAGCCGAAGT TTTCCGGATT TATCTTCAAA 901 ATCCAAGCCA ATATGGACCC GAAACACCGCGACCGTATTG CCTTCTTGCG 951 CGTCTGCTCC GGCAAATTCG AGCGCGGCAT GAAGATGAAACACCTGCGTA 1001 TCAACCGCGA AATCGCCGCC TCCAGCGTGG TTACCTTCAT GTCGCACGAC1051 CGCGAGCTGG TTGAAGAAGC CTACGCCGGC GACATTATCG GCATCCCGAA 1101CCACGGCAAC ATCCAAATCG GCGACAGCTT CTCCGAAGGC GAACAACTGG 1151 CGTTCACCGGCATCCCATTC TTCGCACCCG AACTGTTCCG CAGCGTACGC 1201 ATCAAAAACC CGCTGAAAATCAAACAACTG CAAAAAGGCT TGCAACAGCT 1251 CGGCGAAGAA GGCGCGGTGC AGGTGTTCAAACCGATGAGC GGCGCGGATT 1301 TGATTTTGGG CGCGGTCGGC GTGTTGCAGT TTGAAGTCGTTACCTCGCGC 1351 CTCGCCAACG AATACGGCGT AGAAGCCGTG TTCGACAGCG CATCCATCTG1401 GTCGGCGCGC TGGGTATCGT GCGACGACAA GAAAAAACTG GCTGAATTTG 1451AAAAAGCCAA CGCGGGCAAC CTCGCCATCG ACGCAGGCGG CAACCTCGCC 1501 TACCTCGCCCCCAACCGCGT GAATTTGGGA CTCACGCAAG AACGTTGGCC 1551 GGACATCGTG TTCCACGAAACACGCGAACA TTCGGTCAAA CTGTAAThis corresponds to the amino acid sequence <SEQ ID 514; ORF 134>:

m134.pep 1 MSQEILDQVR RRRTFAIISH PDAGKTTLTE KLLLFSGAIQ SAGTVKGKKT 51GKFATSDWME IEKQRGISVA SSVMQFDYKD HTVNLLDTPG HQDFSEDTYR 101 VLTAVDSALMVIDAAKGVEA QTIKLLNVCR LRDTPIVTFM NKYDREVRDS 151 LELLDEVENI LKIRCAPVTWPIGMGKNFKG VYHILNDEIY LFEAGGERLP 201 HEFDIIKGID NPELEQRFPL EIQQLRDEIELVQAASNEFN LDEFLAGELT 251 PVFFGSAINN FGIQEILNSL IDWAPAPKPR DATVRMVEPDEPKFSGFIFK 301 IQANMDPKHR DRIAFLRVCS GKFERGMKMK HLRINREIAA SSVVTFMSHD351 RELVEEAYAG DIIGIPNHGN IQIGDSFSEG EQLAFTGIPF FAPELFRSVR 401IKNPLKIKQL QKGLQQLGEE GAVQVFKPMS GADLILGAVG VLQFEVVTSR 451 LANEYGVEAVFDSASIWSAR WVSCDDKKKL AEFEKANAGN LAIDAGGNLA 501 YLAPNRVNLG LTQERWPDIVFHETREHSVK L*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 134 shows 98.7% identity over a 531 aa overlap with a predicted ORF(ORF 134.ng) from N. gonorrhoeae:

m134/g134         10        20        30        40        50        60m134.pep MSQEILDQVRRRRTFAIISHPDAGKTTLTEKLLLFSGAIQSAGTVKGKKTGKFATSDWME|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: g134MSQEILDQVRRRRTFAIISHPDAGKTILTEKLLLFSGAIQSAGTVKGKKIGKFATSDWMD        10        20        30        40        50        60        70        80        90       100       110       120 m134.pepIEKQRGISVASSVMQFDYKDHTVNLLDTPGHQDFSEDTYRVLTAVDSALMVIDAAKGVEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g134IEKQRGISVASSVMQFDYKDHTVNLLDTPGHQDFSEDTYRVLTAVDSALMVIDAAKGVEA        70        80        90       100       110       120       130       140       150       160       170       180 m134.pepQTIKLLNVCRLRDTPIVTFMNKYDREVRDSLELLDEVENILKIRCAPVTWPIGMGKNFKG||||||||||||||||||||||||||||||||||||||:||:|||||||||||||||||| g134QTIKLLNVCRLRDTPIVTFMNKYDREVRDSLELLDEVEDILQIRCAPVTWPIGMGKNFKG       130       140       150       160       170       180       190       200       210       220       230       240 m134.pepVYHILNDEIYLFEAGGERLPHEFDIIKGIDNPELEQRFPLEIQQLRDEIELVQAASNEFN|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| g134VYHILNDEIYLFEAGGERLPHEFDIIKGINNPELEQRFPLEIQQLRDEIELVQAASNEFN       190       200       210       220       230       240       250       260       270       280       290       300 m134.pepLDEFLAGELTPVFFGSAINNFGIQEILNSLIDWAPAPKPRDATVRMVEPDEPKFSGFIFK|||||||||||||||||||||||||||||||||||||||||||:||| |||||||||||| g134LDEFLAGELTPVFFGSAINNFGIQEILNSLIDWAPAPKPRDATMRMVGPDEPKFSGFIFK       250       260       270       280       290       300       310       320       330       340       350       360 m134.pepIQANMDPKHRDRIAFLRVCSGKFERGMKMKHLRINREIAASSVVTFMSHDRELVEEAYAG|||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||| g134IQANMDPKHRDRIAFLRVCSGKFERGMKMKHLRINREIAASSVVTFMSHDRELAEEAYAG       310       320       330       340       350       360       370       380       390       400       410       420 m134.pepDIIGIPNHGNIQIGDSFSEGEQLAFTGIPFFAPELFRSVRIKNPLKIKQLQKGLQQLGEE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g134DIIGIPNHGNIQIGDSFSEGEQLAFTGIPFFAPELFRSVRIKNPLKIKQLQKGLQQLGEE       370       380       390       400       410       420       430       440       450       460       470       480 m134.pepGAVQVFKPMSGADLILGAVGVLQFEVVTSRLANEYGVEAVFDSASIWSARWVSCDDKKKL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g134GAVQVFKPMSGADLILGAVGVLQFEVVTSRLANEYGVEAVFDSASIWSARWVSCDDKKKL       430       440       450       460       470       480       490       500       510       520       530 m134.pepAEFEKANAGNLAIDAGGNLAYLAPNRVNLGLTQERWPDIVFHETREHSVKLX|||||||||||||||||||||||||||||||||||||||||||||||||||| g134AEFEKANAGNLAIDAGGNLAYLAPNRVNLGLTQERWPDIVFHETREHSVKLX       490       500       510       520       530The following partial DNA sequence was identified in N. meningitidis<SEQ ID 515>:

a134.seq 1 ATGTCCCAAG AAATCCTCGA CCAAGTGCGC CGCCGCCGCA CGTTTGCCAT 51CATCTCCCAC CCTGACGCAG GTAAAACCAC GTTGACTGAA AAACTCTTGC 101 TGTTTTCAGGTGCGATTCAA AGCGCGGGTA CGGTAAAAGG CAAGAAAACC 151 GGCAAATTCG CCACCTCCGACTGGATGGAC ATCGAGAAGC AGCGCGGCAT 201 TTCCGTGGCA TCAAGCGTGA TGCAGTTCGACTATAAAGAC CACACCGTCA 251 ACCTTTTGGA CACGCCGGGA CACCAAGACT TCTCCGAAGACACCTACCGC 301 GTTTTGACCG CCGTCGATAG TGCCTTGATG GTCATCGACG CGGCAAAAGG351 CGTGGAAGCG CAAACCATCA AACTCTTGAA CGTCTGCCGC CTGCGCAATA 401CGCCGATTGT TACGTTCATG AACAAATACG ACCGCGAAGT GCGCGATTCC 451 CTGGAATTGCTGGACGAAGT GGAAAACATC CTGCAAATCC GCTGCGCGCC 501 CGTAACCTGG CCGATCGGCATGGGCAAAAA CTTCAAAGGC GTGTACCACA 551 TCCTGAACGA CGAAATCTAT CTCTTTGAAGCGGGCGGCGA ACGCTTGCCG 601 CACGAGTTCG ACATCATCAA AGGCATCGAT AATCCCGAATTGGAACAACG 651 CTTTCCGTTA GAAATACAGC AGTTGCGCGA CGAAATCGAA TTGGTGCAGG701 CGGCTTCCAA CGAGTTCAAT CTCGACGAAT TCCTCGCCGG CGAACTCACG 751CCCGTATTCT TCGGCTCTGC GATTAACAAC TTCGGTATTC AGGAAATCCT 801 CAATTCATTGATTGAATGGG CGCCCGCGCC GAAACCACGC GATGCGACCG 851 TGCGTATGGT CGAGCCGGACGAGCCGAAGT TTTCCGGATT TATCTTCAAA 901 ATCCAAGCCA ATATGGACCC GAAACACCGCGACCGTATTG CCTTCTTGCG 951 CGTCTGCTCC GGCAAATTCG AGCGCGGCAT GAAAATGAAACACCTGCGTA 1001 TCAACCGCGA AATCGCCGCC TCCAGCGTGG TAACCTTCAT GTCCCACGAC1051 CGCGAGCTGG TTGAAGAAGC CTACGCCGGC GACATTATCG GTATCCCAAA 1101CCACGGCAAC ATCCAAATCG GCGACAGCTT CTCCGAAGGC GAACAACTGA 1151 CGTTTACCGGCATCCCATTC TTCGCGCCCG AACTGTTCCG CAGCGTTCGC 1201 ATCAAAAACC CGCTGAAAATCAAGCAACTG CAAAAAGGTT TGCAACAGCT 1251 TGGCGAAGAA GGTGCGGTGC AGGTGTTCAAACCAATGAGC GGCGCGGATT 1301 TGATTTTGGG CGCGGTCGGC GTGTTGCAGT TTGAAGTCGTTACCTCGCGC 1351 CTTGCCAACG AATACGGCGT GGAAGCCGTG TTCGACAACG CATCCATCTG1401 GTCGGCGCGC TGGGTATCGT GCGACGACAA GAAAAAACTG GCGGAATTTG 1451AAAAAGCCAA CGCGGGCAAC CTCGCCATCG ACGCGGGCGG CAACCTCGCC 1501 TACCTCGCCCCTAACCGCGT GAATCTGGGA CTCACGCAAG AACGCTGGCC 1551 GGACATCGTG TTCCACGAAACGCGCGAGCA TTCGGTCAAA CTTTAAThis corresponds to the amino acid sequence <SEQ ID 516; ORF 134.a>:

a134.pep 1 MSQEILDQVR RRRTFAIISH PDAGKTTLTE KLLLFSGAIQ SAGTVKGKKT 51GKFATSDWMD IEKQRGISVA SSVMQFDYKD HTVNLLDTPG HQDFSEDTYR 101 VLTAVDSALMVIDAAKGVEA QTIKLLNVCR LRNTPIVTFM NKYDREVRDS 151 LELLDEVENI LQIRCAPVTWPIGMGKNFKG VYHILNDEIY LFEAGGERLP 201 HEFDIIKGID NPELEQRFPL EIQQLRDEIELVQAASNEFN LDEFLAGELT 251 PVFFGSAINN FGIQEILNSL IEWAPAPKPR DATVRMVEPDEPKFSGFIFK 301 IQANMDPKHR DRIAFLRVCS GKFERGMKMK HLRINREIAA SSVVTFMSHD351 RELVEEAYAG DIIGIPNHGN IQIGDSFSEG EQLTFTGIPF FAPELFRSVR 401IKNPLKIKQL QKGLQQLGEE GAVQVFKPMS GADLILGAVG VLQFEVVTSR 451 LANEYGVEAVFDNASIWSAR WVSCDDKKKL AEFEKANAGN LAIDAGGNLA 501 YLAPNRVNLG LTQERWPDIVFHETREHSVK L* m134/a134 98.9% identity in 531 aa overlap        10        20        30        40        50        60 m134.pepMSQEILDQVRRRRTFAIISHPDAGKTTLTEKLLLFSGAIQSAGTVKGKKTGKFATSDWME|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: a134MSQEILDQVRRRRTFAIISHPDAGKTILTEKLLLFSGAIQSAGTVKGKKIGKFATSDWMD        10        20        30        40        50        60        70        80        90       100       110       120 m134.pepIEKQRGISVASSVMQFDYKDHTVNLLDTPGHQDFSEDTYRVLTAVDSALMVIDAAKGVEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a134IEKQRGISVASSVMQFDYKDHTVNLLDTPGHQDFSEDTYRVLTAVDSALMVIDAAKGVEA        70        80        90       100       110       120       130       140       150       160       170       180 m134.pepQTIKLLNVCRLRDTPIVTFMNKYDREVRDSLELLDEVENILKIRCAPVTWPIGMGKNFKG||||||||||||:||||||||||||||||||||||||||||:|||||||||||||||||| a134QTIKLLNVCRLRNTPIVTFMNKYDREVRDSLELLDEVENILQIRCAPVTWPIGMGKNFKG       130       140       150       160       170       180       190       200       210       220       230       240 m134.pepVYHILNDEIYLFEAGGERLPHEFDIIKGIDNPELEQRFPLEIQQLRDEIELVQAASNEFN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a134VYHILNDEIYLFEAGGERLPHEFDIIKGIDNPELEQRFPLEIQQLRDEIELVQAASNEFN       190       200       210       220       230       240       250       260       270       280       290       300 m134.pepLDEFLAGELTPVFFGSAINNFGIQEILNSLIDWAPAPKPRDATVRMVEPDEPKFSGFIFK|||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||| a134LDEFLAGELTPVFFGSAINNFGIQEILNSLIEWAPAPKPRDATVRMVEPDEPKFSGFIFK       250       260       270       280       290       300       310       320       330       340       350       360 m134.pepIQANMDPKHRDRIAFLRVCSGKFERGMKMKHLRINREIAASSVVTFMSHDRELVEEAYAG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a134IQANMDPKHRDRIAFLRVCSGKFERGMKMKHLRINREIAASSVVTFMSHDRELVEEAYAG       310       320       330       340       350       360       370       380       390       400       410       420 m134.pepDIIGIPNHGNIQIGDSFSEGEQLAFTGIPFFAPELFRSVRIKNPLKIKQLQKGLQQLGEE|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| a134DIIGIPNHGNIQIGDSFSEGEQLTFTGIPFFAPELFRSVRIKNPLKIKQLQKGLQQLGEE       370       380       390       400       410       420       430       440       450       460       470       480 m134.pepGAVQVFKPMSGADLILGAVGVLQFEVVTSRLANEYGVEAVFDSASIWSARWVSCDDKKKL||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||| a134GAVQVFKPMSGADLILGAVGVLQFEVVTSRLANEYGVEAVFDNASIWSARWVSCDDKKKL       430       440       450       460       470       480       490       500       510       520       530 m134.pepAEFEKANAGNLAIDAGGNLAYLAPNRVNLGLTQERWPDIVFHETREHSVKLX|||||||||||||||||||||||||||||||||||||||||||||||||||| a134AEFEKANAGNLAIDAGGNLAYLAPNRVNLGLTQERWPDIVFHETREHSVKLX       490       500       510       520       530The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 517>:

g135.seq 1 ATGAAATACA AAAGAATCGT ATTTAAAGTC GGCACATCTT CGATTACCCG 51TTCGGAcgGC AGCCTCTCGC GCGGCAAAAT CCAAACCATC ACCCGCCAGC 101 TTGCCGCATTGCATCATGCG GGACACGAGC TGGTCTTGGT GTCTTCCGGC 151 GCGGTTGCTG CAGGGTTCGGCGCGCTGGGT TTCAAAAAAC GTCCGGTCAA 201 AATCGCCGAC AAACAGGCTT CCGCCGCCGTCGGGCAGGGG CTGCTGATGG 251 AAGAATATAC GGCAAACCTG TCTTCAGACG GCATCGTGTCCGCACAAATC 301 CTGCTCAGCC GTGCCGACTT TGCCGACAAA CGCCGCTACC AAAATGCCGG351 CGGCGCACTT TCCGTGCTGC TGCAACGCCG CGCGATTCCC ATCATCAATG 401AAAACGACAC GGTTTCGGTT GAGGAGTTGA AAATCGGCGA CAACGACACA 451 TTGAGTGCGCAAGTGGCGGC GATGATACAG GCAGACCTCT TGGTGCTGCT 501 GACCGACATA GACGGTCTTTACACCGGCAA CCCGAACAGC AATCCCGATG 551 CCGTACGGCT GGACAAAATC GAACACATCAACCATGAAAT CATCGAAATG 601 GCGGGCGGCT CGGGTTCGGC AAACGGCACG GGCGGTATGCTGACCAAAAT 651 CAAAGCGGCA ACCATCGCCG CCGAATCCGG CGTACCGGTG TATATCTGTT701 CCTCACTCAA ACCCGATTCA TTGGCCGAAG CCGCCGAACA TCAGGCGGAC 751GGCTCGTTTT TCGTcccCcg tgCCAAAGGT TTGCGGACAC AGAAGCAATG 801 GctggCGTTCTATTCcgaaa gcggGGgcag cgttTAtgtg gacgaaagtg 851 cggaacacgc tTtgtccgaacaagggaaag cctgCTGAThis corresponds to the amino acid sequence <SEQ ID 518; ORF 135.ng>:

g135.pep 1 MKYKRIVFKV GTSSITRSDG SLSRGKIQTI TRQLAALHHA GHELVLVSSG 51AVAAGFGALG FKKRPVKIAD KQASAAVGQG LLMEEYTANL SSDGIVSAQI 101 LLSRADFADKRRYQNAGGAL SVLLQRRAIP IINENDTVSV EELKIGDNDT 151 LSAQVAAMIQ ADLLVLLTDIDGLYTGNPNS NPDAVRLDKI EHINHEIIEM 201 AGGSGSANGT GGMLTKIKAA TIAAESGVPVYICSSLKPDS LAEAAEHQAD 251 GSFFVPRAKG LRTQKQWLAF YSESGGSVYV DESAEHALSEQGKAC*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 519>:

m135.seq 1 ATGAAATACA AAAGAATCGT ATTTAAAGTC GGCACATCTT CGATTACCCA 51TTCGGACGGC AGTCTCTCGC GCGGCAAAAT CCAAACCATC ACCTGCCAGC 101 TTGCCGCATTGCATCATGCG GGACACGAGC TGGTCTTGGT GTCTTCCGGC 151 GCGGTTGCGG CAGGGTTCGGTGCGCTGGGT TTCAAAAAAC GTCCGGTCAA 201 AATCGCCGAC AAACAGGCTT CCGCCGCCGTCGGGCAGGGG CTGCTGATGG 251 AAGAATATAC GGCAAACCTG TCTTCAGACG GCATCGTGTCCGCGCAAATC 301 CTGCTCAGCC GCGCCGACTT TGCCGACAAA CGCCGCTACC AAAATGCCGG351 CGGCGCACTT TCCGTGCTGC TGCAACGCCG CGCCGTCCCC ATCATCAATG 401AAAACGATAC GGTTTCGGTT GAGGAATTGA AAATCGGCGA CAACGACACA 451 TTGAGTGCGCAAGTGGCGGC GATGATACAG GCAGACCTCT TGGTGCTGCT 501 GACCGACATA GACGGTCTTTACACGGGCAA CCCGAACAGC AATCCCGATG 551 CCGTACGGCT GGACAAAATC GAACACATCAACCATGAAAT CATCGAAATG 601 GCGGGCGGCT CGGGTTCGGC AAACGGCACG GGCGGTATGCTGACCAAAAT 651 CAAAGCGGCA ACCATCGCCG CCGAATCCGG CGTACCGGTG TATATCTGTT701 CCTCGCTCAA ACCCGATGCA CTTGCCGAAG CTGCCGAACA TCAGGCGGAC 751GGCTCGTTTT TCGTCCCCCG TGCCAAAGGT TTGCGGACGC AGAAGCAATG 801 GCTGGCGTTCTATTCCGAAA GCCGGGGCAG CGTTTATGTG GACGAAGGTG 851 CGGAACACGC TTTGTCCGAACAGGGGAAAA GCCTGCTGAT GTCGGGCATT 901 GCCGGAATCG AAGGGCATTT TTCCCGTATGGACACCGTAA CCGTGTACAG 951 CAAGGCAACC AAACAGCCCC TGGGCAAAGG GCGCGTCCTGTTCGGCTCTG 1001 CCGCCGCCGA AGACCTGCTC AAATCGCGTA AGGCGAAAGG CGTGTTCATC1051 CATCGGGACG ACTGGATTTC CATCACGCCC GAAATACGCC TGCTTCTGAC 1101CGAATTTTAGThis corresponds to the amino acid sequence <SEQ ID 520; ORF 135>:

m135.pep 1 MKYKRIVFKV GTSSITHSDG SLSRGKIQTI TCQLAALHHA GHELVLVSSG 51AVAAGFGALG FKKRPVKIAD KQASAAVGQG LLMEEYTANL SSDGIVSAQI 101 LLSRADFADKRRYQNAGGAL SVLLQRRAVP IINENDTVSV EELKIGDNDT 151 LSAQVAAMIQ ADLLVLLTDIDGLYTGNPNS NPDAVRLDKI EHINHEIIEM 201 AGGSGSANGT GGMLTKIKAA TIAAESGVPVYICSSLKPDA LAEAAEHQAD 251 GSFFVPRAKG LRTQKQWLAF YSESRGSVYV DEGAEHALSEQGKSLLMSGI 301 AGIEGHFSRM DTVTVYSKAT KQPLGKGRVL FGSAAAEDLL KSRKAKGVFI351 HRDDWISITP EIRLLLTEF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 135 shows 97.6% identity over a 294 aa overlap with a predicted ORF(ORF 135.ng) from N. gonorrhoeae:

m135/g135         10        20        30        40        50        60m135.pep MKYKRIVFKVGTSSITHSDGSLSRGKIQTITCQLAALHHAGHELVLVSSGAVAAGFGALG||||||||||||||||:|||||||||||||| |||||||||||||||||||||||||||| g135MKYKRIVFKVGTSSITRSDGSLSRGKIQTITRQLAALHHAGHELVLVSSGAVAAGFGALG        10        20        30        40        50        60        70        80        90       100       110       120 m135.pepFKKRPVKIADKQASAAVGQGLLMEEYTANLSSDGIVSAQILLSRADFADKRRYQNAGGAL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g135FKKRPVKIADKQASAAVGQGLLMEEYTANLSSDGIVSAQILLSRADFADKRRYQNAGGAL        70        80        90       100       110       120       130       140       150       160       170       180 m135.pepSVLLQRRAVPIINENDTVSVEELKIGDNDTLSAQVAAMIQADLLVLLTDIDGLYTGNPNS||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||| g135SVLLQRRAIPIINENDIVSVEELKIGDNDILSAQVAAMIQADLLVLLTDIDGLYTGNPNS       130       140       150       160       170       180       190       200       210       220       230       240 m135.pepNPDAVRLDKIEHINHEIIEMAGGSGSANGTGGMLTKIKAATIAAESGVPVYICSSLKPDA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: g135NPDAVRLDKIEHINHEIIEMAGGSGSANGIGGMLIKIKAATIAAESGVPVYICSSLKPDS       190       200       210       220       230       240       250       260       270       280       290       300 m135.pepLAEAAEHQADGSFFVPRAKGLRTQKQWLAFYSESRGSVYVDEGAEHALSEQGKSLLMSGI|||||||||||||||||||||||||||||||||| |||||||:||||||||||: g135LAEAAEHQADGSFFVPRAKGLRTQKQWLAFYSESGGSVYVDESAEHALSEQGKACX       250       260       270       280       290       310       320       330       340       350       360 m135.pepAGIEGHFSRMDTVTVYSKATKQPLGKGRVLFGSAAAEDLLKSRKAKGVFIHRDDWISITPThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 521>:

a135.seq 1 ATGAAATACA AAAGAATCGT ATTTAAAGTC GGCACATCTT CGATTACCCA 51TTCGGACGGC AGTCTCTCGC GCGGCAAAAT CCAAACCATC ACCCGCCAGC 101 TTGCCGCATTGCATCATGCG GGACACGAGC TGGTCTTGGT GTCTTCCGGC 151 GCGGTTGCGG CAGGGTTCGGTGCGCTGGGT TTCAAAAAAC GTCCGGTCAA 201 AATCGCCGAC AAACAGGCTT CCGCCGCCGTCGGGCAGGGG CTGCTGATGG 251 AAGAATATAC GGCAAACCTG TCTTCAGACG GCATCGTGTCCGCACAAATC 301 CTGCTCAGCC GCGCCGACTT TGCCGACAAA CGCCGCTACC AAAATGCCGG351 CGGCGCACTT TCCGTGCTGC TGCAACGCCG CGCCGTCCCC ATCATCAATG 401AAAACGATAC GGTTTCGGTT GAGGAATTGA AAATCGGCGA CAACGACACA 451 TTGAGTGCGCAAGTGGCGGC GATGATACAG GCAGACCTCT TGGTGCTGCT 501 GACCGACATA GACGGTCTTTACACCGGCAA CCCGAACAGC AATCCCGATG 551 CCGTACGGCT GGACAAAATC GAACACATCAACCATGAAAT CATCGAAATG 601 GCGGGCGGCT CGGGTTCGGC AAACGGCACA GGCGGTATGCTGACTAAAAT 651 CAAAGCGGCG ACGATTGCGA CCGAGTCCGG CGTACCGGTC TATATCTGTT701 CCTCGCTCAA ACCCGATGCA CTTGCCGAAG CGGCAGATAA TCAGGCGGAC 751GGCTCGTTTT TCGTCCCCCG TGCCAAAGGT TTGCGGACGC AGAAGCAATG 801 GCTGGCGTTCTATTCCGAAA GCAGGGGCGG CGTTTATGTG GACGAAGGTG 851 CGGAACACGC TTTGTCCGAACAGGGAAAAA GCCTGCTGAT GTCGGGCATT 901 GCCGGAATCG AAGGGCATTT TTCCCGTATGGACACCGTAA CCGTGTACAG 951 CAAGGCAACC AAACAGCCTT TGGGCAAAGG GCGAGTCCTGTTCGGCTCTG 1001 CCGCCGCCGA AGACCTGCTC AAATTGCGTA AGGCGAAAGG CGTGTTCATC1051 CATCGGGACG ACTGGATTTC CATCACGCCC GAAATACGCC TGCTTCTGAC 1101CGAATTTTAGThis corresponds to the amino acid sequence <SEQ ID 522; ORF 135.a>:

a135.pep 1 MKYKRIVFKV GTSSITHSDG SLSRGKIQTI TRQLAALHHA GHELVLVSSG 51AVAAGFGALG FKKRPVKIAD KQASAAVGQG LLMEEYTANL SSDGIVSAQI 101 LLSRADFADKRRYQNAGGAL SVLLQRRAVP IINENDTVSV EELKIGDNDT 151 LSAQVAAMIQ ADLLVLLTDIDGLYTGNPNS NPDAVRLDKI EHINHEIIEM 201 AGGSGSANGT GGMLTKIKAA TIATESGVPVYICSSLKPDA LAEAADNQAD 251 GSFFVPRAKG LRTQKQWLAF YSESRGGVYV DEGAEHALSEQGKSLLMSGI 301 AGIEGHFSRM DTVTVYSKAT KQPLGKGRVL FGSAAAEDLL KLRKAKGVFI351 HRDDWISITP EIRLLLTEF* m135/a135 98.4% identity in 369 aa overlap        10        20        30        40        50        60 m135.pepMKYKRIVFKVGTSSITHSDGSLSRGKIQTITCQLAALHHAGHELVLVSSGAVAAGFGALG||||||||||||||||||||||||||||||| |||||||||||||||||||||||||||| a135MKYKRIVFKVGTSSITHSDGSLSRGKIQTITRQLAALHHAGHELVLVSSGAVAAGFGALG        10        20        30        40        50        60        70        80        90       100       110       120 m135.pepFKKRPVKIADKQASAAVGQGLLMEEYTANLSSDGIVSAQILLSRADFADKRRYQNAGGAL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a135FKKRPVKIADKQASAAVGQGLLMEEYTANLSSDGIVSAQILLSRADFADKRRYQNAGGAL        70        80        90       100       110       120       130       140       150       160       170       180 m135.pepSVLLQRRAVPIINENDTVSV EELKIGDNDTLSAQVAAMIQADLLVLLTDIDGLYTGNPNS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a135SVLLQRRAVPIINENDIVSVEELKIGDNDILSAQVAAMIQADLLVLLTDIDGLYTGNPNS       130       140       150       160       170       180       190       200       210       220       230       240 m135.pepNPDAVRLDKIEHINHEIIEMAGGSGSANGTGGMLTKIKAATIAAESGVPVYICSSLKPDA|||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||| a135NPDAVRLDKIEHINHEIIEMAGGSGSANGIGGMLIKIKAATIATESGVPVYICSSLKPDA       190       200       210       220       230       240       250       260       270       280       290       300 m135.pepLAEAAEHQADGSFFVPRAKGLRTQKQWLAFYSESRGSVYVDEGAEHALSEQGKSLLMSGI|||||::|||||||||||||||||||||||||||||:||||||||||||||||||||||| a135LAEAADNQADGSFFVPRAKGLRTQKQWLAFYSESRGGVYVDEGAEHALSEQGKSLLMSGI       250       260       270       280       290       300       310       320       330       340       350       360 m135.pepAGIEGHFSRMDTVTVYSKATKQPLGKGRVLFGSAAAEDLLKSRKAKGVFIHRDDWISITP||||||||||||||||||||||||||||||||||||||||| |||||||||||||||||| a135AGIEGHFSRMDTVTVYSKATKQPLGKGRVLFGSAAAEDLLKLRKAKGVFIHRDDWISITP       310       320       330       340       350       360        370m135.pep EIRLLLTEFX |||||||||| a135 EIRLLLTEFX        370The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 523>:

g136.seq 1 ATGGAAATCC GGTTTCAGAC AGCATTTTTA CGTTTGGTTC AGatgaAAAC 51AAACGCTtca aTTCTtaccg caACACGCCT TGTATTTCCT GccgCTGCCG 101 CACGGACAGGGATCGTTCCT GCCGgtTTTT TCCCCTTCCC TGCGGACGGT 151 TTGCGGTTTG TTGATGACCGCCTGCCAGTA GCGGTAGATG TCtgccagcg 201 cgTAAGGCag tTCGGAcgca agttccgccagctcgccttc ggTGAATTGC 251 AGgcggataa cgccgtttTC CTCTTCGTCg taaatgccgcccactgccat 301 cacgGGGTAA AACAGCTCTT CAAACGCTTC ATCATCGGCG GCTTCAAACC351 AATCGGTCGG CACAATGTCC AAACCGTAAA GATAGGCGTT GCACCAAGTG 401TAAAAATCGC TGCCGCCCTC GCCGTCGTCG TAGAGCCACA AATCGGGCAG 451 CTTTTTATCCGACATCGCGG CGGTTGTTTC CATCGCCATT GCCAAAACCA 501 GCCGTTCGAT TTCGGAACGTTCGGCGGCGG TAAATTGCGA TTCGTCGCCC 551 AACACTTCGG GCAGCCAGTC GAGCGGTGCCAATTTGTCCG GCCCGCTCAA 601 CAGCGCCGTC ATAAAACCTT GAACCTCGTC GCAACGCATCGTGTTGCCTT 651 GTTCGCTTTT GGCATCCAAT AAThis corresponds to the amino acid sequence <SEQ ID 524; ORF 136.ng>:

g136.pep 1 MEIRFQTAFL RLVQMKTNAS ILTATRLVFP AAAARTGIVP AGFFPFPADG 51LRFVDDRLPV AVDVCQRVRQ FGRKFRQLAF GELQADNAVF LFVVNAAHCH 101 HGVKQLFKRFIIGGFKPIGR HNVQTVKIGV APSVKIAAAL AVVVEPQIGQ 151 LFIRHRGGCF HRHCQNQPFDFGTFGGGKLR FVAQHFGQPV ERCQFVRPAQ 201 QRRHKTLNLV ATHRVALFAF GIQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 525>:

m136.seq 1 ATGGAAACAA ACGCTTCAAT TCTTACCGCA ACACGCCTTG TATTTTCTGC 51CGCTGCCGCA CGGACAGGGA TCGTTCCTGC CTGTTTTTTC GCCTTCCCTG 101 CGGACGGTTTGCGGTTTGTT GATGACTGCC TGCCAGTAGC GGTAGATATC 151 CGCCAATGCA TAAGGCAACTCGGATTCCAG TTCCGCCAGC TCGCCTTCTG 201 TGAATTGCAG ACGGATAGCG CCGTTTTCCTCTTCGTCGTA AATACCGCCC 251 AATGCCATGA TGGGATAAAA CAACTCTTCA AACGCTTCATCATCGACGGC 301 TTCAAACCAA TCGGTCGGCA CAATATCCAA ACCGTAAAGA TAAGCATTGC351 ACCATGTGTA AAAATCGCTG CCGCCGTCTT CGTTTTCATA CAGCCACAAA 401TCGGGCAGTT TTTTATCCGA CATCGCGGCG GTTGTTTCCA TCGCCATTGC 451 CAAAACCAGCCGTTCGATTT CGGAACGTTC GGCGGCGGTA AATTGCGATT 501 CGTCGCCCAA CACTTCGGGCAGCCAGTCGA GCGGTGTCAA TTTGTCCGGC 551 CCGCTCAACA GCGCCGTCAT AAAACCTTGAACCTCGTCGC AACGCATCGT 601 GTTGCCTTGT TCGCTTTTGG CATCCAACAA TTCGCTCAACCGCCGTTTGG 651 ATGCTTCGGT AAATTTTCGG GAATCCATCA TTTTCCTTTT CAAATGGGTT701 TTGCGCCCTA TTATCGCCGC AATGCCGTCT GAThis corresponds to the amino acid sequence <SEQ ID 526; ORF 136>:

m136.pep 1 METNASILTA TRLVFSAAAA RTGIVPACFF AFPADGLRFV DDCLPVAVDI 51RQCIRQLGFQ FRQLAFCELQ TDSAVFLFVV NTAQCHDGIK QLFKRFIIDG 101 FKPIGRHNIQTVKISIAPCV KIAAAVFVFI QPQIGQFFIR HRGGCFHRHC 151 QNQPFDFGTF GGGKLRFVAQHFGQPVERCQ FVRPAQQRRH KTLNLVATHR 201 VALFAFGIQQ FAQPPFGCFG KFSGIHHFPFQMGFAPYYRR NAV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 136 shows 85.6% identity over a 209 aa overlap with a predicted ORF(ORF 136.ng) from N. gonorrhoeae:

m136/g136                       10        20        30        40m136.pep               METNASILTATRLVFSAAAARTGIVPACFFAFPADGLRFVDDCLPV              |:||||||||||||| ||||||||||| || ||||||||||| ||| g136MEIRFQTAFLRLVQMKTNASILTATRLVFPAAAARTGIVPAGFFPFPADGLRFVDDRLPV        10        20        30        40        50        60  50        60        70        80        90       100 m136.pepAVDIRQCIRQLGFQFRQLAFCELQTDSAVFLFVVNTAQCHDGIKQLFKRFIIDGFKPIGR |||:| :||:| :|||||| |||:|:||||||||:|:|| |:||||||||| ||||||| g136AVDVCQRVRQFGRKFRQLAFGELQADNAVFLFVVNAAHCHHGVKQLFKRFIIGGFKPIGR        70        80        90       100       110       120 110       120       130       140       150       160 m136.pepHNIQTVKISIAPCVKIAAAVFVFIQPQIGQFFIRHRGGCFHRHCQNQPFDFGTFGGGKLR||:|||||::|| ||||||: | ::|||||:||||||||||||||||||||||||||||| g136HNVQTVKIGVAPSVKIAAALAVVVEPQIGQLFIRHRGGCFHRHCQNQPFDFGTFGGGKLR       130       140       150       160       170       180 170       180       190       200       210       220 m136.pepFVAQHFGQPVERCQFVRPAQQRRHKTLNLVATHRVALFAFGIQQFAQPPFGCFGKFSGIH||||||||||||||||||||||||||||||||||||||||||| g136FVAQHFGQPVERCQFVRPAQQRRHKTLNLVATHRVALFAFGIQX       190       200       210       220  230       240 m136.pepHFPFQMGFAPYYRRNAVXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 527>:

a136.seq 1 ATGGAAACAA ACGCTTCAAT TCTTACCGCA ACACGCCTTG TATTTTCTGC 51CGCTGCCGCA CGGACAGGGA TCGTTCCTGC CTGTTTTTTC GCCTTCCCTG 101 CGGACGGTTTGCGGCTTGTT GATGACCGCC TGCCAGTAGC GGTAGATATC 151 CGCCAATGCA TAAGGCAACTCGGATTCCAG TTCCGCCAGC TCGCCTTCTG 201 TGAATTGCAG ACGGATAGTG CCGTTGTCCTCTTCGTCGTA AATACCGCCC 251 AATGCCATGA TGGGATAAAA CAACTCTTCA AACGCTTCATCATCGACGGC 301 TTCAAACCAA TCGGTCGGCA CAATATCCAA ACCGTAAAGA TAAGCATTGC351 ACCATGTGTA AAAATCGCTG CCGCCGTCTT CGTTTTCATA CAGCCACAAA 401TCGGGCAGTT TTTTATCCGA CATCGCGGCG GTTGTTTCCA TCGCCATTGC 451 CAAAACCAGCCGTTCGATTT CGGAACGTTC GGCGGCGGTA AATTGCGATT 501 CGTCGCCCAA CACTTCGGGCAGCCAGTCGA GCGGTGTCAA TTTGTCCGGC 551 CCGCTCAACA GCGCCGTCAT AAAACCTTGAACCTCGTCGC AACGCATCGT 601 GTTGCCTTGT TCGCTTTTGG CATCCAACAA TTCGCTCAACCGCCGTTTGG 651 ATGCTTCGGT AAATTTTCGG GAATCCATCA TTTTCCTTTT CCAATGGGTT701 TTGCGCCCTA TTATAGTGGA TTAAATTTAA ATCAGGACAA GGCGACGAAG 751CCGCAGACAG TACAAATAGT ACGGCAAGGC GAGGCAACGC CGTACTGGTT 801 TAAATTTAATCCACTATATC GCCGCAATGC CGTCTGAThis corresponds to the amino acid sequence <SEQ ID 528; ORF 136.a>:

a136.pep 1 METNASILTA TRLVFSAAAA RTGIVPACFF AFPADGLRLV DDRLPVAVDI 51RQCIRQLGFQ FRQLAFCELQ TDSAVVLFVV NTAQCHDGIK QLFKRFIIDG 101 FKPIGRHNIQTVKISIAPCV KIAAAVFVFI QPQIGQFFIR HRGGCFHRHC 151 QNQPFDFGTF GGGKLRFVAQHFGQPVERCQ FVRPAQQRRH KTLNLVATHR 201 VALFAFGIQQ FAQPPFGCFG KFSGIHHFPFPMGFAPYYSG LNLNQDKATK 251 PQTVQIVRQG EATPYWFKFN PLYRRNAV* m136/a13698.3% identity in 238 aa overlap        10        20        30        40        50        60 m136.pepMETNASILTATRLVFSAAAARTGIVPACFFAFPADGLRFVDDCLPVAVDIRQCIRQLGFQ||||||||||||||||||||||||||||||||||||||:||| ||||||||||||||||| a136METNASILTATRLVFSAAAARTGIVPACFFAFPADGLRLVDDRLPVAVDIRQCIRQLGFQ        10        20        30        40        50        60        70        80        90       100       110       120 m136.pepFRQLAFCELQTDSAVFLFVVNTAQCHDGIKQLFKRFIIDGFKPIGRHNIQTVKISIAPCV||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| a136FRQLAFCELQTDSAVVLFVVNTAQCHDGIKQLFKRFIIDGFKPIGRHNIQTVKISIAPCV        70        80        90       100       110       120       130       140       150       160       170       180 m136.pepKIAAAVFVFIQPQIGQFFIRHRGGCFHRHCQNQPFDFGTFGGGKLRFVAQHFGQPVERCQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a136KIAAAVFVFIQPQIGQFFIRHRGGCFHRHCQNQPFDFGTFGGGKLRFVAQHFGQPVERCQ       130       140       150       160       170       180       190       200       210       220       230       240 m136.pepFVRPAQQRRHKTLNLVATHRVALFAFGIQQFAQPPFGCFGKFSGIHHFPFQMGFAPYYRR|||||||||||||||||||||||||||||||||||||||||||||||||| ||||||| a136FVRPAQQRRHKTLNLVATHRVALFAFGIQQFAQPPFGCFGKFSGIHHFPFPMGFAPYYSG       190       200       210       220       230       240 m136.pepNAVX a136 LNLNQDKATKPQTVQIVRQGEATPYWFKFNPLYRRNAVX       250       260       270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 529>:

g137.seq 1 ATGATTATCC ATCACcaaTT CGATCCCGTC CTCATCAGTA TCGGCCCGCT 51TGCCGTCCGC TGGTATGCCT TAAGCTACAT CCTCGGATTT ATTCTTTTTA 101 CCTTTCTCGGCAGAAGGCGC ATCGCGCAAG GCTTGTCCGT TTTTACCAAA 151 GAATCGCTCG ACGACTTCCTGACATGGGGC ATTTTGGGCG TGATTTTGGG 201 CGGACGCTTG GGCTATGTCC TGTTTTACAAATTCTCCGAC TACCTCGCCC 251 ATCCGCTTGA TATTTTCAAG GTATGGGAAG GCGGAATGTCGTTCCACGGC 301 GGCTTTTTGG GTGTAGTTAT TGCCATATGG TTGTTCAGCC GCAAGCACGG351 CATCGGCTTC CTCAAACTGA TGGACACGGT CGCGCCGCTC GTTCCGCTGG 401GTCTCGCTTC GGGACGTATC GGCAACTTTA TCAACGGCGA ACTTTGGGGA 451 CGCATTACCGACATTAACGC ATTTTGGGCA ATGGGCTTCC CGCAAGCGCA 501 TTACGAAGAT GCCGAAGCCGCCGCGCACAA TCCGCTTTGG GCAGAATGGC 551 TGCAACAATA CGGTATGCTG CCGCGTCATCCCTCGCAGCT TTATCAGTTT 601 GCCCTTGAAG GCATCTGCCT GTTCGCCGTC GTTTGGCTGTTTTCCAAAAA 651 ACCGCGCCCG ACCGGGCAGA CTGCCGCGCT TTTTCTCGGC GGCTACGGCG701 TGTTCCGCTT TATTGCCGAA TTTGCGCGCC AACCCGACGA CTATCTCGGG 751CTGCTGACCT TGGGGCTGTC GATGGGGCAA TGGTTGAGCG TCCCGATGAT 801 TGTTTTGGGTATCGTCGGCT TTGTCCGGTT CGGCATGAAA AAACAGCACT 851 GAThis corresponds to the amino acid sequence <SEQ ID 530; ORF 137.ng>:

g137.pep 1 MIIHHQFDPV LISIGPLAVR WYALSYILGF ILFTFLGRRR IAQGLSVFTK 51ESLDDFLTWG ILGVILGGRL GYVLFYKFSD YLAHPLDIFK VWEGGMSFHG 101GFLGVVIAIW LFSRKHGIGF LKLMDTVAPL VPLGLASGRI GNFINGELWG 151 RITDINAFWAMGFPQAHYED AEAAAHNPLW AEWLQQYGML PRHPSQLYQF 201 ALEGICLFAV VWLFSKKPRPTGQTAALFLG GYGVFRFIAE FARQPDDYLG 251 LLTLGLSMGQ WLSVPMIVLG IVGFVRFGMKKQH*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 531>:

m137.seq 1 ATGATTACCC ATCCCCAATT CGATCCCGTC CTTATCAGTA TCGGCCCGCT 51TGCCGTCCGC TGGTATGCCC TAAGCTACAT CCTCGGATTT ATTCTTTTTA 101 CCTTTCTCGGCAGAAGGCGC ATCGCGCAAG GCTTGTCCGT TTTTACCAAA 151 GAATCGCTCG ACGACTTCCTGACATGGGGC ATTTTGGGCG TAATTTTGGG 201 CGGGCGTTTG GGTTACGTCC TGTTTTACAAGTTTTCCGAC TACCTCGCCC 251 ATCCGCTTGA TATTTTCAAG GTATGGGAAG GCGGAATGTCGTTCCACGGC 301 GGCTTTTTGG GTGTAGTTAT TGCCATACGG TTGTTCGGCC GCAAACACGG351 CATCGGCTTC CTCAAACTGA TGGATACGGT CGCACCGCTC GTTCCGCTGG 401GTCTCGCTTC GGGACGTATC GGCAACTTCA TCAACGGCGA ACTTTGGGGA 451 CGCGTTACCGACATCAACGC ATTTTGGGCA ATGGGCTTCC CGCAGGCGCG 501 TTACGAAGAT GCCGAAGCCGCCGCGCACAA TCCGCTTTGG GCAGAATGGC 551 TGCAACAATA CGGTATGCTG CCGCGTCATCCCTCGCAGCT TTATCAGTTT 601 GCACTTGAAG GCATCTGCCT GTTCACCGTC ATTTGGCTGTTCTCTAAAAA 651 ACAGCGGTCG ACCGGACAAG TCGCCTCGCT CTTCCTCGGC GGCTACGGCA701 TATTCCGCTT CATTGCCGAA TTCGCACGCC AACCCGACGA CTATCTCGGG 751CTGCTGACCT TGGGGCTGTC GATGGGGCAA TGGTTGAGCG TCCCGATGAT 801 TGTTTTGGGTATCGTCGGCT TTGTCCGGTT CGGCATGAAA AAACAGCACT 851 GAThis corresponds to the amino acid sequence <SEQ ID 532; ORF 137>:

m137.pep 1 MITHPQFDPV LISIGPLAVR WYALSYILGF ILFTFLGRRR IAQGLSVFTK 51ESLDDFLTWG ILGVILGGRL GYVLFYKFSD YLAHPLDIFK VWEGGMSFHG 101GFLGVVIAIR LFGRKHGIGF LKLMDTVAPL VPLGLASGRI GNFINGELWG 151 RVTDINAFWAMGFPQARYED AEAAAHNPLW AEWLQQYGML PRHPSQLYQF 201 ALEGICLFTV IWLFSKKQRSTGQVASLFLG GYGIFRFIAE FARQPDDYLG 251 LLTLGLSMGQ WLSVPMIVLG IVGFVRFGMKKQH*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 137 shows 95.4% identity over a 283 aa overlap with a predicted ORF(ORF 137.ng) from N. gonorrhoeae:

m137/g137         10        20        30        40        50        60m137.pep MITHPQFDPVLISIGPLAVRWYALSYILGFILFTFLGRRRIAQGLSVFTKESLDDFLTWG|| | ||||||||||||||||||||||||||||||||||||||||||||||||||||||| g137MIIHHQFDPVLISIGPLAVRWYALSYILGFILFTFLGRRRIAQGLSVFTKESLDDFLTWG        10        20        30        40        50        60        70        80        90       100       110       120 m137.pepILGVILGGRLGYVLFYKFSDYLAHPLDIFKVWEGGMSFHGGFLGVVIAIRLFGRKHGIGF||||||||||||||||||||||||||||||||||||||||||||||||| ||:||||||| g137ILGVILGGRLGYVLFYKFSDYLAHPLDIFKVWEGGMSFHGGFLGVVIAIWLFSRKHGIGF        70        80        90       100       110       120       130       140       150       160       170       180 m137.pepLKLMDTVAPLVPLGLASGRIGNFINGELWGRVTDINAFWAMGFPQARYEDAEAAAHNPLW|||||||||||||||||||||||||||||||:||||||||||||||:||||||||||||| g137LKLMDTVAPLVPLGLASGRIGNFINGELWGRITDINAFWAMGFPQAHYEDAEAAAHNPLW       130       140       150       160       170       180       190       200       210       220       230       240 m137.pepAEWLQQYGMLPRHPSQLYQFALEGICLFTVIWLFSKKQRSTGQVASLFLGGYGIFRFIAE||||||||||||||||||||||||||||:|:|||||| | |||:|:|||||||:|||||| g137AEWLQQYGMLPRHPSQLYQFALEGICLFAVVWLFSKKPRPTGQTAALFLGGYGVFRFIAE       190       200       210       220       230       240       250       260       270       280 m137.pepFARQPDDYLGLLTLGLSMGQWLSVPMIVLGIVGFVRFGMKKQHX|||||||||||||||||||||||||||||||||||||||||||| g137FARQPDDYLGLLTLGLSMGQWLSVPMIVLGIVGFVRFGMKKQHX       250       260       270       280The following partial DNA sequence was identified in N. meningitidis<SEQ ID 533>:

a137.seq 1 ATGATTACCC ATCCCCAATT CGACCCCGTC CTTATCAGTA TCGGCCCGCT 51TGCCGTCCGC TGGTATGCCC TAAGCTACAT CCTCGGATTT ATTCTTTTTA 101 CCTTTCTCGGCAGAAGGCGC ATCGCGCAAG GCTTGTCCGT TTTTACCAAA 151 GAATCGCTCG ACGACTTCCTGACATGGGGC ATTTTGGGCG TAATTTTGGG 201 CGGGCGTTTG GGTTACGTCC TGTTTTACAAGTTTTCCGAC TACCTCGCCC 251 ATCCGCTTGA TATTTTCAAG GTATGGGAAG GCGGAATGTCGTTCCACGGC 301 GGCTTTTTGG GTGTAGTTAT TGCCATATGG TTGTTCGGTC GCAAACACGG351 CATCGGCTTC CTCAAACTGA TGGACACGGT CGCACCGCTC GTTCCACTGG 401GTCTCGCTTC GGGACGTATC GGCAACTTCA TCAACGGCGA ACTTTGGGGA 451 CGCGTTACCGACATCAACGC ATTTTGGGCA ATGGGCTTCC CGCAGGCGCG 501 TTACGAAGAC CTCGAAGCCGCCGCGCACAA TCCGCTTTGG GCAGAATGGC 551 TGCAACAATA CGGTATGCTG CCGCGTCATCCCTCGCAGCT TTATCAGTTT 601 GCACTTGAAG GCATCTGCCT GTTCGCCGTC GTTTGGCTGTTCTCTAAAAA 651 ACAGCGGCCG ACCGGACAAG TCGCCTCACT CTTCCTCGGC GGCTACGGCA701 TATTCCGCTT CATTGCCGAA TTTGCACGCC AACCCGACGA CTATCTCGGG 751CTGCTGACCT TGGGGCTGTC GATGGGGCAA TGGTTGAGCG TCCCGATGAT 801 TGTTTTGGGTATCGTCGGCT TTGTCCGGTT CGGCATGAAA AAACAGCACT 851 GAThis corresponds to the amino acid sequence <SEQ ID 534; ORF 137.a>:

a137.pep 1 MITHPQFDPV LISIGPLAVR WYALSYILGF ILFTFLGRRR IAQGLSVFTK 51ESLDDFLTWG ILGVILGGRL GYVLFYKFSD YLAHPLDIFK VWEGGMSFHG 101GFLGVVIAIW LFGRKHGIGF LKLMDTVAPL VPLGLASGRI GNFINGELWG 151 RVTDINAFWAMGFPQARYED LEAAAHNPLW AEWLQQYGML PRHPSQLYQF 201 ALEGICLFAV VWLFSKKQRPTGQVASLFLG GYGIFRFIAE FARQPDDYLG 251 LLTLGLSMGQ WLSVPMIVLG IVGFVRFGMKKQH* m137/a137 98.2% identity in 283 aa overlap        10        20        30        40        50        60 m137.pepMITHPQFDPVLISIGPLAVRWYALSYILGFILFTFLGRRRIAQGLSVFTKESLDDFLTWG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a137MITHPQFDPVLISIGPLAVRWYALSYILGFILFTFLGRRRIAQGLSVFTKESLDDFLTWG        10        20        30        40        50        60        70        80        90       100       110       120 m137.pepILGVILGGRLGYVLFYKFSDYLAHPLDIFKVWEGGMSFHGGFLGVVIAIRLFGRKHGIGF||||||||||||||||||||||||||||||||||||||||||||||||| |||||||||| a137ILGVILGGRLGYVLFYKFSDYLAHPLDIFKVWEGGMSFHGGFLGVVIAIWLFGRKHGIGF        70        80        90       100       110       120       130       140       150       160       170       180 m137.pepLKLMDTVAPLVPLGLASGRIGNFINGELWGRVTDINAFWAMGFPQARYEDAEAAAHNPLW|||||||||||||||||||||||||||||||||||||||||||||||||| ||||||||| a137LKLMDTVAPLVPLGLASGRIGNFINGELWGRVTDINAFWAMGFPQARYEDLEAAAHNPLW       130       140       150       160       170       180       190       200       210       220       230       240 m137.pepAEWLQQYGMLPRHPSQLYQFALEGICLFTVIWLFSKKQRSTGQVASLFLGGYGIFRFIAE||||||||||||||||||||||||||||:|:|||||||| |||||||||||||||||||| a137AEWLQQYGMLPRHPSQLYQFALEGICLFAVVWLFSKKQRPTGQVASLFLGGYGIFRFIAE       190       200       210       220       230       240       250       260       270       280 m137.pepFARQPDDYLGLLTLGLSMGQWLSVPMIVLGIVGFVRFGMKKQHX|||||||||||||||||||||||||||||||||||||||||||| a137FARQPDDYLGLLTLGLSMGQWLSVPMIVLGIVGFVRFGMKKQHX       250       260       270       280The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 535>:

g138.seq 1 ATGGAGTTTG AAAACATTAT TTCCGCCGCc gaCAAGGCGC GTATCCTTGC 51CGAAGCACTG CCTTACAtcc gccgGTTTTC CGGTTCGGTC GCCGTCATCA 101 AGTATGGCGGCAACGCGATG ACCGAACCTG CCTTGAAAGA AGGGTTTGCC 151 CGCGATGTCG TGCTGCTGAAGCTGGTCGGC ATTCATCCCG TCATCGTTCA 201 CGGCGGCGGG CCGCAGATCA ATGCGATGCTTGAAAAAGTC GGCAAAAAGG 251 GCGAATTTGT CCAAGGAATG CGCGTTACCG ACAAAGAGACGATGGATATT 301 GTCGAAATGG TATTGGGCGG GCACGTCAAC AAGGAAATCG TGTCGATGAT351 TAACACATAT GGAGGGCACG CGGTCGGCGT GAGCGGGCGC GACGACCATT 401TCATTAAGGC GAAGAAACTT TTGGTCGATA CGCCCGAACA GAATAGCGTG 451 GACATCGGACAGGTCGGTAC GGTGGAAAGC ATCGATACCG GTTTGGTTAA 501 AGGGCTGATA GAACGCGGCTGCATTCCCGT CGTCGCCCCC GTCGGCGTAG 551 GTGAAAAAGG CGAAGCGTTC AACATCAACGCCGATTTGGT GGCAGGCAAA 601 TTGGCGGAAG AATTGAACGC CGAAAAACTC TTGATGATGACGAAtatcgc 651 cgGTGTGATG GACAAAACGG GCAATCTGCT GACCAAACTC acgCCGAAAC701 GGATTGATGG GCTGATTGCC GACGGCACGC TGTATGGCGG TATGCTGCCG 751AAAATCGCTT CTGCGGTCGA AGCcgccgtc aACGGTGTGA AAGCCACGCA 801 CATCATCGACGGCAGGTTGC CCAACGCGCT TTTGCTGGAA ATCTTTACCG 851 ATGCCGGTAT CGGGTCGATGATTTTAGGCA GAGGGGAAGA TGCCTGAThis corresponds to the amino acid sequence <SEQ ID 536; ORF 138.ng>:

g138.pep 1 MEFENIISAA DKARILAEAL PYIRRFSGSV AVIKYGGNAM TEPALKEGFA 51RDVVLLKLVG IHPVIVHGGG PQINAMLEKV GKKGEFVQGM RVTDKETMDI 101 VEMVLGGHVNKEIVSMINTY GGHAVGVSGR DDHFIKAKKL LVDTPEQNSV 151 DIGQVGTVES IDTGLVKGLIERGCIPVVAP VGVGEKGEAF NINADLVAGK 201 LAEELNAEKL LMMTNIAGVM DKTGNLLTKLTPKRIDGLIA DGTLYGGMLP 251 KIASAVEAAV NGVKATHIIDGRLPNALLLE IFTDAGIGSM ILGRGEDA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 537>:

m138.seq 1 ATGGAGTCTG AAAACATTAT TTCCGCCGCC GACAAGGCGC GTATCCTTGC 51CGAAGCGCTG CCTTACATCC GCCGGTTTTC CGGTTCGGTC GCCGTCATCA 101 AATACGGCGGCAACGCGATG ACCGAACCTG CCTTGAAAGA AGGGTTTGCC 151 CGCGATGTCG TGCTGCTGAAGCTGGTCGGC ATTCATCCCG TCATCGTTCA 201 CGGCGGCGGG CCGCAGATCA ATGCGATGCTTGAAAAAGTC GGCAAAAAGG 251 GTGAGTTTGT CCAAGGAATG CGCGTTACCG ACAAAGAGGCGATGGATATT 301 GTCGAAATGG TGTTGGGCGG GCATGTCAAT AAAGAAATCG TGTCGATGAT351 TAACACATAT GGCGGACACG CGGTCGGCGT AAGCGGACGC GACGACCATT 401TCATTAAGGC GAAGAAACTT TTGATCGATA CGCCCGAACA GAATGGCGTG 451 GACATCGGACAGGTCGGTAC GGTGGAAAGC ATCGATACCG GTTTGGTTAA 501 AGGGCTGATA GAACGTGGCTGCATTCCCGT CGTCGCCCCC GTCGGCGTAG 551 GTGAAAAAGG CGAAGCGTTC AACATCAACGCCGATTTGGT AGCAGGCAAA 601 TTGGCGGAAG AATTGAACGC CGAAAAACTC TTGATGATGACGAATATCGC 651 CGGTGTGATG GACAAAACGG GCAATCTGCT GACCAAACTC ACGCCGAAAC701 GGATTGATGA ACTGATTGCC GACGGCACGC TGTATGGCGG TATGCTGCCG 751AAAATCGCTT CTGCGGTCGA AGCCGCCGTC AACGGTGTGA AAGCCACGCA 801 TATCATCGACGGCAGGTTGC CCAACGCGCT TTTGCTGGAA ATCTTTACCG 851 ATGCCGGTAT CGGTTCGATGATTTTGGGCG GTGGGGAAGA TGCCTGAThis corresponds to the amino acid sequence <SEQ ID 538; ORF 138>:

m138.pep 1 MESENIISAA DKARILAEAL PYIRRFSGSV AVIKYGGNAM TEPALKEGFA 51RDVVLLKLVG IHPVIVHGGG PQINAMLEKV GKKGEFVQGM RVTDKEAMDI 101 VEMVLGGHVNKEIVSMINTY GGHAVGVSGR DDHFIKAKKL LIDTPEQNGV 151 DIGQVGTVES IDTGLVKGLIERGCIPVVAP VGVGEKGEAF NINADLVAGK 201 LAEELNAEKL LMMTNIAGVM DKTGNLLTKLTPKRIDELIA DGTLYGGMLP 251 KIASAVEAAV NGVKATHIIDGRLPNALLLE IFTDAGIGSM ILGGGEDA*Computer analysis of tins amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 138 shows 98.0% identity over a 298 aa overlap with a predicted ORF(ORF 138.ng) from N. gonorrhoeae:

m138/g138         10        20        30        40        50        60m138.pep MESENIISAADKARILAEALPYIRRFSGSVAVIKYGGNAMTEPALKEGFARDVVLLKLVG|| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g138MEFENIISAADKARILAEALPYIRRFSGSVAVIKYGGNAMTEPALKEGFARDVVLLKLVG        10        20        30        40        50        60        70        80        90       100       110       120 m138.pepIHPVIVHGGGPQINAMLEKVGKKGEFVQGMRVTDKEAMDIVEMVLGGHVNKEIVSMINTY||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||| g138IHPVIVHGGGPQINAMLEKVGKKGEFVQGMRVTDKETMDIVEMVLGGHVNKEIVSMINTY        70        80        90       100       110       120       130       140       150       160       170       180 m138.pepGGHAVGVSGRDDHFIKAKKLLIDTPEQNGVDIGQVGTVESIDTGLVKGLIERGCIPVVAP|||||||||||||||||||||:||||||:||||||||||||||||||||||||||||||| g138GGHAVGVSGRDDHFIKAKKLLVDTPEQNSVDIGQVGTVESIDTGLVKGLIERGCIPVVAP       130       140       150       160       170       180       190       200       210       220       230       240 m138.pepVGVGEKGEAFNINADLVAGKLAEELNAEKLLMMTNIAGVMDKTGNLLTKLTPKRIDELIA|||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||| g138VGVGEKGEAFNINADLVAGKLAEELNAEKLLMMTNIAGVMDKTGNLLTKLTPKRIDGLIA       190       200       210       220       230       240       250       260       270       280       290      299 m138.pepDGTLYGGMLPKIASAVEAAVNGVKATHIIDGRLPNALLLEIFTDAGIGSMILGGGEDAX||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||| g138DGTLYGGMLPKIASAVEAAVNGVKATHIIDGRLPNALLLEIFTDAGIGSMILGRGEDAX       250       260       270       280       290The following partial DNA sequence was identified in N. meningitidis<SEQ ID 539>:

a138.seq 1 ATGGAGTCTG AAAACATTAT TTCCGCCGCC GACAAGGCGC GTATCCTTGC 51CGAAGCGCTG CCTTACATCC GCCGGTTTTC CGGTTCGGTC GCCGTCATCA 101 AATACGGCGGCAACGCGATG ACCGAACCTG CCTTGAAAGA AGGGTTTGCC 151 CGCGATGTCG TGCTGCTGAAGCTGGTCGGC ATTCATCCCG TCATCGTTCA 201 CGGCGGCGGG CCGCAGATCA ATGCGATGCTTGAAAAAGTC GGCAAAAAGG 251 GTGAGTTTGT CCAAGGAATG CGCGTTACCG ACAAAGAGGCGATGGATATT 301 GTCGAAATGG TGTTGGGCGG GCATGTCAAT AAAGAAATCG TGTCGATGAT351 TAACACATAT GGCGGACACG CGGTCGGCGT AAGCGGACGC GACGACCATT 401TCATTAAGGC GAAGAAACTT TTGATCGATA CGCCCGAACA GAATGGCGTG 451 GACATCGGACAGGTCGGTAC GGTGGAAAGC ATCGATACCG GTTTGGTTAA 501 AGGGCTGATA GAACGTGGCTGCATTCCCGT CGTCGCCCCC GTCGGCGTAG 551 GTGAAAAAGG CGAAGCGTTC AACATCAACGCCGATTTGGT AGCAGGCAAA 601 TTGGCGGAAG AATTGAACGC CGAAAAACTC TTGATGATGACGAATATCGC 651 CGGTGTGATG GACAAAACGG GCAATCTGCT GACCAAACTC ACGCCGAAAC701 GGATTGATGA ACTGATTGCC GACGGCACGC TGTATGGCGG TATGCTGCCG 751AAAATCGCTT CTGCGGTCGA AGCCGCCGTC AACGGCGTGA AAGCCACGCA 801 TATCATCGACGGCAGGGTGC CCAACGCGCT TTTGCTGGAA ATCTTTACCG 851 ATGCCGGTAT CGGTTCGATGATTTTGGGCG GTGGGGAAGA TGCCTGAThis corresponds to the amino acid sequence <SEQ ID 540; ORF 138.a>:

a138.pep 1 MESENIISAA DKARILAEAL PYIRRFSGSV AVIKYGGNAM TEPALKEGFA 51RDVVLLKLVG IHPVIVHGGG PQINAMLEKV GKKGEFVQGM RVTDKEAMDI 101 VEMVLGGHVNKEIVSMINTY GGHAVGVSGR DDHFIKAKKL LIDTPEQNGV 151 DIGQVGTVES IDTGLVKGLIERGCIPVVAP VGVGEKGEAF NINADLVAGK 201 LAEELNAEKL LMMTNIAGVMDKTGNLLTKL TPKRIDELIA DGTLYGGMLP 251 KIASAVEAAV NGVKATHIID GRVPNALLLEIFTDAGIGSM ILGGGEDA* m138/a138 99.7% identity in 298 aa overlap        10        20        30        40        50        60 m138.pepMESENIISAADKARILAEALPYIRRFSGSVAVIKYGGNAMTEPALKEGFARDVVLLKLVG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a138MESENIISAADKARILAEALPYIRRFSGSVAVIKYGGNAMTEPALKEGFARDVVLLKLVG        10        20        30        40        50        60        70        80        90       100       110       120 m138.pepIHPVIVHGGGPQINAMLEKVGKKGEFVQGMRVTDKEAMDIVEMVLGGHVNKEIVSMINTY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a138IHPVIVHGGGPQINAMLEKVGKKGEFVQGMRVTDKEAMDIVEMVLGGHVNKEIVSMINTY        70        80        90       100       110       120       130       140       150       160       170       180 m138.pepGGHAVGVSGRDDHFIKAKKLLIDTPEQNGVDIGQVGTVESIDTGLVKGLIERGCIPVVAP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a138GGHAVGVSGRDDHFIKAKKLLIDTPEQNGVDIGQVGTVESIDTGLVKGLIERGCIPVVAP       130       140       150       160       170       180       190       200       210       220       230       240 m138.pepVGVGEKGEAFNINADLVAGKLAEELNAEKLLMMTNIAGVMDKTGNLLTKLTPKRIDELIA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a138VGVGEKGEAFNINADLVAGKLAEELNAEKLLMMTNIAGVMDKTGNLLTKLTPKRIDELIA       190       200       210       220       230       240       250       260       270       280       290      299 m138.pepDGTLYGGMLPKIASAVEAAVNGVKATHIIDGRLPNALLLEIFTDAGIGSMILGGGEDAX||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||| a138DGTLYGGMLPKIASAVEAAVNGVKATHIIDGRVPNALLLEIFTDAGIGSMILGGGEDAX       250       260       270       280       290The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 541>:

g139.seq 1 ATGCGAACCA CCTCAACCTT CCCTACAAAA ACTTTCAAAC CGGCTGCCAT 51GGCGTTAGCT GTTGCAACAA CACTTTCTGC CTGCTTAggc ggcggcggag 101 gcGGCACTTCTGCTCCCGAC TTTAATGCAG GCGGCACCGG TATCGGCAGC 151 AACAGCAGGG CAACGATAGCGGAATCAGCA GCAGTATCTT ACGCCGGTAT 201 AAAAAACGAA ATGTGCAAAG ACAGAAGCATGCTCTGTGCC GGTCGGGATG 251 ACGTTGCGGT TACAGACAGG GATGCCAAAA TCAAAGCCCCCCGAATCTGC 301 ATACCGGAGA CTTTTCAAAC CCAAATGACC AATATTAAGA ATATGATCAA351 CCTCAAACCT GCAATTGAAG CAGGCTATAC AGGACGCGGG GTAGAGGTAG 401GTATCGTCGA TACAGGCGAA TCCGTCGGCA GCATATCCTT TCCCGAACTG 451 TATGGCAGAAAAGAACACGG CTATAACGAA AATTACAAAA ACAAATTACA 501 AAAACTATAC GGCGTATATGCGGAAGGAAG CGCCTGAThis corresponds to the amino acid sequence <SEQ ID 542; ORF 138.ng>:

g139.pep 1 MRTTSTFPTK TFKPAAMALA VATTLSACLG GGGGGTSAPD FNAGGTGIGS 51NSRATIAESA AVSYAGIKNE MCKDRSMLCA GRDDVAVTDR DAKIKAPRIC 101 IPETFQTQMTNIKNMINLKP AIEAGYTGRG VEVGIVDTGE SVGSISFPEL 151 YGRKEHGYNE NYKNKLQKLYGVYAEGSA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 543>:

m139.seq 1 ATGCGAACGA CCCCAACCTT CCCTACAAAA ACTTTCAAAC CGACTGCCAT 51GGCGTTAGCT GTTGCAACAA CACTTTCTGC CTGCTTAGGC GGCGGCGGAG 101 GCGGCACTTCTGCGCCCGAC TTCAATGCAG GCGGTACCGG TATCGGCAGC 151 AACAGCAGAG CAACAACAGCGAAATCAGCA GCAGTATCTT ACGCCGGTAT 201 CAAGAACGAA ATGTGCAAAG ACAGAAGCATGCTCTGTGCC GGTCGGGATG 251 ACGTTGCGGT TACAGACAGG GATGCCAAAA TCAATGCCCCCCCCCGAATC 301 TGCATACCGG AGACTTTCCA AACCCAAATG ACGCATtACA AGAATTTGAT351 CAACCTCAAA CCTGCAATTG AAGCAGGCTA TACAGGACGC GGGGTAGAGG 401TAGGTATCGT CGACACAGGC GAATCCGTCG GCAGCATATC CTTTCCCGAA 451 CTGTATGGCAGAAAAGAACA CGGCTATAAC GAAAATTACG AAAAACTATA 501 CGGCGTATAT GCGGAAGGAAGCGCCTGAThis corresponds to the amino acid sequence <SEQ ID 544; ORF 138>:

m139.pep 1 MRTTPTFPTK TFKPTAMALA VATTLSACLG GGGGGTSAPD FNAGGTGIGS 51NSRATTAKSA AVSYAGIKNE MCKDRSMLCA GRDDVAVTDR DAKINAPPRI 101 CIPETFQTQMTHYKNLINLK PAIEAGYTGR GVEVGIVDTG ESVGSISFPE 151 LYGRKEHGYN ENYEKLYGVYAEGSA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 138 shows 92.2% identity over a 179 aa overlap with a predicted ORF(ORF 138.ng) from N. gonorrhoeae:

m139/g139           10        20        30        40        50        60m139.pep   MRTTPTFPTKTFKPTAMALAVATTLSACLGGGGGGTSAPDFNAGGTGIGSNSRATTAKSA  |||| |||||||||:|||||||||||||||||||||||||||||||||||||||| |:|| g139  MRTTSTFPTKTFKPAAMALAVATTLSACLGGGGGGTSAPDFNAGGTGIGSNSRATIAESA          10        20        30        40        50        60          70        80        90       100       110       120 m139.pep  AVSYAGIKNEMCKDRSMLCAGRDDVAVTDRDAKINAPPRICIPETFQTQMTHYKNLINLK  ||||||||||||||||||||||||||||||||||:|| |||||||||||||: ||:|||| g139  AVSYAGIKNEMCKDRSMLCAGRDDVAVTDRDAKIKAP-RICIPETFQTQMTNIKNMINLK          70        80        90        100       110         130       140       150       160           170 m139.pep  PAIEAGYTGRGVEVGIVDTGESVGSISFPELYGRKEHGYNENY----EKLYGVYAEGSAX  |||||||||||||||||||||||||||||||||||||||||||    :|||||||||||| g139  PAIEAGYTGRGVEVGIVDTGESVGSISFPELYGRKEHGYNENYKNKLQKLYGVYAEGSAX120       130       140       150       160       170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 545>:

a139.seq 1 ATGCGAACGA CCCCAACCTT CCCTACAAAA ACTTTCAAAC CGGCTGCCAT 51GGCGTTAGCT GTTGCAACAA CACTTTCTGC CTGCTTAGGC GGCGGCGGAG 101 GCGGCACTTCTGCGCCCGAC TTCAATGCAG GCGGCACCGG TATCGGCAGC 151 AACAGCAGGG CAACAACAGCGAAATCAGCA GCAATATCTT ACGCCGGTAT 201 CAAGAACGAA ATGTGCAAAG ACAGAAGCATGCTCTGTGCC GGTCGGGATG 251 ACGTTGCGGT TACAGACAGG GATGCCAAAA TCAATGCCCCCCCCCGAATC 301 TGCATACCGG AGACTTTACA AACCCAAATG ACGCAT.ACA AGAATTTGAT351 CAACCTCAAA CCTGCAATTG AAGCAGGCTA TACAGGACGC GGGGTAGAGG 401TAGGTATCGT CGACACAGGC GAATCCGTCG GCAGCATATC CTTTCCCGAA 451 CTGTATGGCAGAAAAGAACA CGGCTATAAC GAAAATTAC. AAAAACTATA 501 CGGCGTATAT GCGGAAGGAAGCGCCTGAThis corresponds to the amino acid sequence <SEQ ID 546; ORF 139.a>:

a139.pep 1 MRTTPTFPTK TFKPAAMALA VATTLSACLG GGGGGTSAPD FNAGGTGIGS 51NSRATTAKSA AISYAGIKNE MCKDRSMLCA GRDDVAVTDR DAKINAPPRI 101 CIPETLQTQMTHXKNLINLK PAIEAGYTGR GVEVGIVDTG ESVGSISFPE 151 LYGRKEHGYN ENYXKLYGVYAEGSA* m139/a139 97.1% identity in 175 aa overlap        10        20        30        40        50        60 m139.pepMRTTPTFPTKTFKPTAMALAVATTLSACLGGGGGGTSAPDFNAGGTGIGSNSRATTAKSA||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||| a139MRTTPTFPTKTFKPAAMALAVATTLSACLGGGGGGTSAPDFNAGGTGIGSNSRATTAKSA        10        20        30        40        50        60        70        80        90       100       110       120 m139.pepAVSYAGIKNEMCKDRSMLCAGRDDVAVTDRDAKINAPPRICIPETFQTQMTHYKNLINLK|:|||||||||||||||||||||||||||||||||||||||||||:|||||| ||||||| a139AISYAGIKNEMCKDRSMLCAGRDDVAVTDRDAKINAPPRICIPETLQTQMTHXKNLINLK        70        80        90       100       110       120       130       140       150       160       170 m139.pepPAIEAGYTGRGVEVGIVDTGESVGSISFPELYGRKEHGYNENYEKLYGVYAEGSAX||||||||||||||||||||||||||||||||||||||||||| |||||||||||| a139PAIEAGYTGRGVEVGIVDTGESVGSISFPELYGRKEHGYNENYXKLYGVYAEGSAX       130       140       150       160       170The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 547>:

g140.seq 1 Atgtcggcac gCGGCAAGGG GGCAGgctat ctcAACAGTA CCGGACGACa 51TGTTCCCTTC CTGAGTGCCG CCAAAATCGG GCAGGATTAT TCTTTCTTCA 101 AAAATATCAAAACCGACGGC GGTCTGCTGG CTTCCCTCGA CAGCGTCGAA 151 AAAACAGCGG GCAGTGAAGGCGACACGCCG TCCTATTATG TCCGTCGCGG 201 CAATGCGGCA CGGACTGCTT CGGCAGCGGCACATTCCGCG CCCGCCGGTC 251 TGAAACACGC CGTAGAACAG GGCGGCAGCA ATCTGGAAAACCTGATGGTC 301 GAGCTGGATG CCTCCGAATC ATCCGCAACA CCCGAGACGG TTGAAACTGC351 GGTCGCCGAC CGCACAGATA TGCCGGGCAT CCGCCTACGG CGCACAACTT 401TCCGCACAGC GGCAGCCGTA CAGCATGCGA ATACCGCCGA CGGCGTACGc 451 aTCTTcaaCAGTCTCGCCGC TAccgTCTAt GccgACAGTG CCGCCGCCCA 501 TGccgATATG CAGGGACGCCGCCTGAAAGC CGTATCGGAC GGGTTGGACC 551 ACAACGGTAC GGGTCTGCGC GTCATCGCGCAAACCCAACA GGACGGTGGA 601 ACGTGGGAAC AGGGCGGTGT CGAAGGCAAA ATGCGCGGCAGTACCCAAAC 651 TATCGGCATT GCCGCGAAAA CCGGCGAAAA TACGACAGCA GCCGCCACAC701 TGGGCATAGG ACGCAGCACA TGGAGCGAAA ACAGTGCAAA TGCAAAAACC 751GACAGCATTA GTCTGTTTGC AGGCATACGG CACGATGTGG GCGATATCGG 801 CTATCTCAAAGGCCTGTTCT CctaCGGACG CTACAAAAAC AGCATCAGCC 851 GCAGCACCGG TGCGGATGAATATGCGGAAG GCAGCGTCAA CGGCACGCTG 901 ATGCAGCTGG GCGCACTGGG TGGTGTCAACGTTCCGTTTG CCGCAACGGG 951 AGATTTGACG GTTGAAGGCG GTCTGCGCCA CGACCTGCTCAAACAGGATG 1001 CATTCGCCGA AAAAGGCagt GCTTTGGGCT GGAGCGGCAA CAGCCTCACT1051 GAAGGCACAC TGGTCGGACT CGCGGGTCTG AAACTGTCGC AACCCTTGAG 1101CGATAAAGCC GTCCTGTCTG CGACGGCGGG CGTGGAACGC GACCTGAACG 1151 GACGCGACTACGCGGTAACG GGCGGCTTTA CCGGCGCGGC TGCAGCAACC 1201 GGCAAGACGG GTGCACGCAATATGCCGCAC ACCCGCCGGG TTGCCGGTCT 1251 GGGGGTGGAT GTCGAATTCG GCAACGGCTGGAACGGCTTG GCACGTTACA 1301 GCTACACCGG TTCCAAACAG TACGGCAACC ACAGCGGACAAATCGGCGTA 1351 GGCTACCGGT TCTGAThis corresponds to the amino acid sequence <SEQ ID 548; ORF 140.ng>:

g140.pep 1 MSARGKGAGY LNSTGRHVPF LSAAKIGQDY SFFKNIKTDG GLLASLDSVE 51KTAGSEGDTP SYYVRRGNAA RTASAAAHSA PAGLKHAVEQ GGSNLENLMV 101 ELDASESSATPETVETAVAD RTDMPGIRLR RTTFRTAAAV QHANTADGVR 151 IFNSLAATVY ADSAAAHADMQGRRLKAVSD GLDHNGTGLR VIAQTQQDGG 201 TWEQGGVEGK MRGSTQTIGI AAKTGENTTAAATLGIGRST WSENSANAKT 251 DSISLFAGIR HDVGDIGYLK GLFSYGRYKN SISRSTGADEYAEGSVNGTL 301 MQLGALGGVN VPFAATGDLT VEGGLRHDLL KQDAFAEKGS ALGWSGNSLT351 EGTLVGLAGL KLSQPLSDKA VLSATAGVER DLNGRDYAVT GGFTGAAAAT 401GKTGARNMPH TRRVAGLGVD VEFGNGWNGL ARYSYTGSKQ YGNHSGQIGV 451 GYRF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 549>:

m140.seq 1 ATGTCGGCAC GCGGCAAGGG GGCAGGCTAT CTCAACAGTA CCGGACGACG 51TGTTCCCTTC CTGAGTGCCG CCAAAATCGG GCAGGATTAT TCTTTCTTCA 101 CAAACATCGAAACCGACGGC GGCCTGCTGG CTTCCCTCGA CAGCGTCGAA 151 AAAACAGCGG GCAGTGAAGGCGACACGCTG TCCTATTATG TCCGTCGCGG 201 CAATGCGGCA CGGACTGCTT CGGCAGCGGCACATTCCGCG CCCGCCGGTC 251 TGAAACACGC CGTAGAACAG GGCGGCAGCA ATCTGGAAAACCTGATGGTC 301 GAACTGGATG CCTCCGAATC ATCCGCAACA CCCGAGACGG TTGAAACTGC351 GGCAGCCGAC CGCACAGATA TGCCGGGCAT CCGCCCCTAC GGCGCAACTT 401TCCGCGCAGC GGCAGCCGTA CAGCATGCGA ATGCCGCCGA CGGTGTACGC 451 ATCTTCAACAGTCTCGCCGC TACCGTCTAT GCCGACAGTA CCGCCGCCCA 501 TGCCGATATG CAGGGACGCCGCCTGAAAGC CGTATCGGAC GGGTTGGACC 551 ACAACGGCAC GGGTCTGCGC GTCATCGCGCAAACCCAACA GGACGGTGGA 601 ACGTGGGAAC AGGGCGGTGT TGAAGGCAAA ATGCGCGGCAGTACCCAAAC 651 CGTCGGCATT GCCGCGAAAA CCGGCGAAAA TACGACAGCA GCCGCCACAC701 TGGGCATGGG ACGCAGCACA TGGAGCGAAA ACAGTGCAAA TGCAAAAACC 751GACAGCATTA GTCTGTTTGC AGGCATACGG CACGATGCGG GCGATATCGG 801 CTATCTCAAAGGCCTGTTCT CCTACGGACG CTACAAAAAC AGCATCAGCC 851 GCAGCACCGG TGCGGACGAACATGCGGAAG GCAGCGTCAA CGGCACGCTG 901 ATGCAGCTGG GCGCACTGGG CGGTGTCAACGTTCCGTTTG CCGCAACGGG 951 AGATTTGACG GTCGAAGGCG GTCTGCGCTA CGACCTGCTCAAACAGGATG 1001 CATTCGCCGA AAAAGGCAGT GCTTTGGGCT GGAGCGGCAA CAGCCTCACT1051 GAAGGCACGC TGGTCGGACT CGCGGGTCTG AAGCTGTCGC AACCCTTGAG 1101CGATAAAGCC GTCCTGTTTG CAACGGCGGG CGTGGAACGC GACCTGAACG 1151 GACGCGACTACACGGTAACG GGCGGCTTTA CCGGCGCGAC TGCAGCAACC 1201 GGCAAGACGG GGGCACGCAATATGCCGCAC ACCCGTCTGG TTGCCGGCCT 1251 GGGCGCGGAT GTCGAATTCG GCAACGGCTGGAACGGCTTG GCACGTTACA 1301 GCTACGCCGG TTCCAAACAG TACGGCAACC ACAGCGGACGAGTCGGCGTA 1351 GGCTACCGGT TCTGAThis corresponds to the amino acid sequence <SEQ ID 550; ORF 140>:

m140.pep 1 MSARGKGAGY LNSTGRRVPF LSAAKIGQDY SFFTNIETDG GLLASLDSVE 51KTAGSEGDTL SYYVRRGNAA RTASAAAHSA PAGLKHAVEQ GGSNLENLMV 101 ELDASESSATPETVETAAAD RTDMPGIRPY GATFRAAAAV QHANAADGVR 151 IFNSLAATVY ADSTAAHADMQGRRLKAVSD GLDHNGTGLR VIAQTQQDGG 201 TWEQGGVEGK MRGSTQTVGI AAKTGENTTAAATLGMGRST WSENSANAKT 251 DSISLFAGIR HDAGDIGYLK GLFSYGRYKN SISRSTGADEHAEGSVNGTL 301 MQLGALGGVN VPFAATGDLT VEGGLRYDLL KQDAFAEKGS ALGWSGNSLT351 EGTLVGLAGL KLSQPLSDKA VLFATAGVER DLNGRDYTVT GGFTGATAAT 401GKTGARNMPH TRLVAGLGAD VEFGNGWNGL ARYSYAGSKQ YGNHSGRVGV 451 GYRF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 140 shows 94.5% identity over a 454 aa overlap with a predicted ORF(ORF 140.ng) from N. gonorrhoeae:

m140/g140         10        20        30        40        50        60m140.pep MSARGKGAGYLNSTGRRVPFLSAAKIGQDYSFFTNIETDGGLLASLDSVEKTAGSEGDTL||||||||||||||||:|||||||||||||||| ||:|||||||||||||||||||||| g140MSARGKGAGYLNSTGRHVPFLSAAKIGQDYSFFKNIKTDGGLLASLDSVEKTAGSEGDTP        10        20        30        40        50        60        70        80        90       100       110       120 m140.pepSYYVRRGNAARTASAAAHSAPAGLKHAVEQGGSNLENLMVELDASESSATPETVETAAAD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| g140SYYVRRGNAARTASAAAHSAPAGLKHAVEQGGSNLENLMVELDASESSATPETVETAVAD        70        80        90       100       110       120       130       140       150       160       170       180 m140.pepRTDMPGIRPYGATFRAAAAVQHANAADGVRIFNSLAATVYADSTAAHADMQGRRLKAVSD||||||||  :|||:||||||||:||||||||||||||||||:|||||||||||||||| g140RTDMPGIRLRRTTFRTAAAVQHANTADGVRIFNSLAATVYADSAAAHADMQGRRLKAVSD       130       140       150       160       170       180       190       200       210       220       230       240 m140.pepGLDHNGTGLRVIAQTQQDGGTWEQGGVEGKMRGSTQTVGIAAKTGENTTAAATLGMGRST|||||||||||||||||||||||||||||||||||||:|||||||||||||||||:|||| g140GLDHNGTGLRVIAQTQQDGGTWEQGGVEGKMRGSTQTIGIAAKTGENTTAAATLGIGRST       190       200       210       220       230       240       250       260       270       280       290       300 m140.pepWSENSANAKTDSISLFAGIRHDAGDIGYLKGLFSYGRYKNSISRSTGADEHAEGSVNGTL||||||||||||||||||||||:|||||||||||||||||||||||||||:||||||||| g140WSENSANAKTDSISLFAGIRHDVGDIGYLKGLFSYGRYKNSISRSTGADEYAEGSVNGTL       250       260       270       280       290       300       310       320       330       340       350       360 m140.pepMQLGALGGVNVPFAATGDLTVEGGLRYDLLKQDAFAEKGSALGWSGNSLTEGTLVGLAGL||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| g140MQLGALGGVNVPFAATGDLTVEGGLRHDLLKQDAFAEKGSALGWSGNSLTEGTLVGLAGL       310       320       330       340       350       360       370       380       390       400       410       420 m140.pepKLSQPLSDKAVLFATAGVERDLNGRDYTVTGGFTGATAATGKTGARNMPHTRLVAGLGAD|||||||||||| ||||||||||||||:||||||||:||||||||||||||| |||||:| g140KLSQPLSDKAVLSATAGVERDLNGRDYAVTGGFTGAAAATGKTGARNMPHTRRVAGLGVD       370       380       390       400       410       420       430       440       450 m140.pepVEFGNGWNGLARYSYAGSKQYGNHSGRVGVGYRFX |||||||||||||||:||||||||||::|||||||g140 VEFGNGWNGLARYSYTGSKQYGNHSGQIGVGYRFX        430       440       450The following partial DNA sequence was identified in N. meningitidis<SEQ ID 551>:

a140.seq 1 ATGTCGGCAG GCGGTAAGGG GGCAGGCTAT CTCAACCGTA CCGGACAACG 51TGTTCCCTTC CTGAGTGCCG CCAAAATCGG GCGGGATTAT TCTTTCTTCA 101 CAAACATCGAAACCGACGGC GGTCTGCTGG CTTCCCTCGA CAGCGTCGAA 151 AAAACAGCGG GTAGTGAAGGCGACACGCTG TCCTATTATG TCCGTCGCGG 201 CAATGCGGCA CGGACTGCTT CGGCAGCGGCACATTCCGCG CCCGCCGGTC 251 TGAAACACGC CGTAGAACAG GGCGGCAGCA ATCTGGAAAACCTGATGGTC 301 GAACTGGATG CCTCCGAATC ATCCGCAACA CCCGAGACGG TTGAAACTGC351 GGCCGCCGAC CGCACAGATA TGCCGGGCAT CCGCCCCTAC GGCGCAACTT 401TCCGCGCAGC GGCAGCCGTA CAGCATGCGA ATGCCGCCGA CGGTGTACGC 451 ATCTTCAACAATCTCGCCGC TACCGTCTAT GCCGACAGTA CCGCCGCCCA 501 TGCCGATATG CAGGGACGCCGCCTGAAAGC CGTATCGGAC GGGTTGGACC 551 ACAACGCTAC GGGTCTGCGC GTCATCGCGCAAACCCAACA GGACGGTGGA 601 ACGTGGGAAC AGGGCGGTGT TGAAGGCAAA ATGCGCGGCAGTACCCAAAC 651 CGTCGGCATT GCCGCGAAAA CCGGCGAAAA TACGACAGCA GCCGCCACAC701 TGGGCATGGG ACACAGCACA TGGAGCGAAA ACAGTGCAAA TGCAAAAACC 751GACAGCATTA GTCTGTTTGC AGGCATACGG CACGATGCGG GCGATATCGG 801 CTATCTCAAAGGCCTGTTCT CCTACGGACG CTACAAAAAC AGCATCAGCC 851 GCAGCACCGG TGCGGACGAACATGCGGAAG GCAGCGTCAA CGGCACGCTG 901 ATGCAGCTGG GCGCACTGGG CGGTGTCAACGTTCCGTTTG CCGCAACGGG 951 AGATTTGACG GTCGAAGGCG GTCTGCGCTA CGACCTGCTCAAACAGGATG 1001 CATTCGCCGA AAAAGGCAGT GCTTTGGGCT GGAGCGGCAA CAGCATCACT1051 GAAGGCACAC TGGTCGGACT CGCGGGTCTG AAGCTGTCGC AACCCTTGAG 1101CGATAAAGCC GTCCTGTTTG CAACGGCGGG CGTGGAACGC GACCTGAACG 1151 GACGCGACTACACGGTAACG GGCGGCTTTA CCGGCGCGAC TGCAGCAACC 1201 GGCAAGACGG GGGCACGCAATATGCCGCAC ACCCGCCTGG TTGCCGGTCT 1251 GGGCGCGGAT GTCGAATTCG GCAACGGCTGGAACGGCTTG GCACGTTACA 1301 GCTACGCCGG TTCCAAACAG TACGGCAACC ACAGCGGACGAGTCGGCGTA 1351 GGCTACCGGT TCTGAThis corresponds to the amino acid sequence <SEQ ID 552; ORF 140.a>:

a140.pep 1 MSAGGKGAGY LNRTGQRVPF LSAAKIGRDY SFFTNIETDG GLLASLDSVE 51KTAGSEGDTL SYYVRRGNAA RTASAAAHSA PAGLKHAVEQ GGSNLENLMV 101 ELDASESSATPETVETAAAD RTDMPGIRPY GATFRAAAAV QHANAADGVR 151 IFNNLAATVY ADSTAAHADMQGRRLKAVSD GLDHNATGLR VIAQTQQDGG 201 TWEQGGVEGK MRGSTQTVGI AAKTGENTTAAATLGMGHST WSENSANAKT 251 DSISLFAGIR HDAGDIGYLK GLFSYGRYKN SISRSTGADEHAEGSVNGTL 301 MQLGALGGVN VPFAATGDLT VEGGLRYDLL KQDAFAEKGS ALGWSGNSIT351 EGTLVGLAGL KLSQPLSDKA VLFATAGVER DLNGRDYTVT GGFTGATAAT 401GKTGARNMPH TRLVAGLGAD VEFGNGWNGL ARYSYAGSKQ YGNHSGRVGV 451 GYRF*m140/a140 98.2% identity in 454 aa overlap        10        20        30        40        50        60 m140.pepMSARGKGAGYLNSTGRRVPFLSAAKIGQDYSFFTNIETDGGLLASLDSVEKTAGSEGDTL||| |||||||| ||:|||||||||||:|||||||||||||||||||||||||||||||| a140MSAGGKGAGYLNRTGQRVPFLSAAKIGRDYSFFTNIETDGGLLASLDSVEKTAGSEGDTL        10        20        30        40        50        60        70        80        90       100       110       120 m140.pepSYYVRRGNAARTASAAAHSAPAGLKHAVEQGGSNLENLMVELDASESSATPETVETAAAD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a140SYYVRRGNAARTASAAAHSAPAGLKHAVEQGGSNLENLMVELDASESSATPETVETAAAD        70        80        90       100       110       120       130       140       150       160       170       180 m140.pepRTDMPGIRPYGATFRAAAAVQHANAADGVRIFNSLAATVYADSTAAHADMQGRRLKAVSD|||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||| a140RTDMPGIRPYGATFRAAAAVQHANAADGVRIFNNLAATVYADSTAAHADMQGRRLKAVSD       130       140       150       160       170       180       190       200       210       220       230       240 m140.pepGLDHNGTGLRVIAQTQQDGGTWEQGGVEGKMRGSTQTVGIAAKTGENTTAAATLGMGRST|||||:|||||||||||||||||||||||||||||||||||||||||||||||||||:|| a140GLDHNATGLRVIAQTQQDGGTWEQGGVEGKMRGSTQTVGIAAKTGENTTAAATLGMGHST       190       200       210       220       230       240       250       260       270       280       290       300 m140.pepWSENSANAKTDSISLFAGIRHDAGDIGYLKGLFSYGRYKNSISRSTGADEHAEGSVNGTL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a140WSENSANAKTDSISLFAGIRHDAGDIGYLKGLFSYGRYKNSISRSTGADEHAEGSVNGTL       250       260       270       280       290       300       310       320       330       340       350       360 m140.pepMQLGALGGVNVPFAATGDLTVEGGLRYDLLKQDAFAEKGSALGWSGNSLTEGTLVGLAGL||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||| a140MQLGALGGVNVPFAATGDLTVEGGLRYDLLKQDAFAEKGSALGWSGNSITEGTLVGLAGL       310       320       330       340       350       360       370       380       390       400       410       420 m140.pepKLSQPLSDKAVLFATAGVERDLNGRDYTVTGGFTGATAATGKTGARNMPHTRLVAGLGAD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a140KLSQPLSDKAVLFATAGVERDLNGRDYTVTGGFTGATAATGKTGARNMPHTRLVAGLGAD       370       380       390       400       410       420       430       440       450 m140.pepVEFGNGWNGLARYSYAGSKQYGNHSGRVGVGYRFX |||||||||||||||||||||||||||||||||||a140 VEFGNGWNGLARYSYAGSKQYGNHSGRVGVGYRFX        430       440       450The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 553>:

g141.seq 1 atgagcttca aAAccgATGC CGAAACCGCC CAATCCTCCA CCATGCGCCC 51GATTGGCGAA ATTGCCGCCA AGCTGGGTTT GAACGTTGAC AACATTGAGC 101 CTTACGGTCATTACAAAGCC AAAATCAATC CTGCCGAAGC GTTCAAGCTG 151 CCGCAAAAAC AAGGCAGGCTGATTTTGGTT ACCGCCATCA ACCCGACTCC 201 GGCGGGCGAA GGCAAAACCA CCGTAACCATCGGTTTGGCG GACGCATTGC 251 GCCATATCGG CAAAGACTCT GTGATTGCTT TGCGCGAGCCTTCTTTGGGT 301 CCGGTGTTCG GCGTGAAAGG CGGCGCGGCA GGCGGCGGCT ACGCGCAAGT351 TTTGCCGATG GAAGACATCA ACCTGCACTT CACCGGCGAC TTCCACGCCA 401TCGGTGCGGC GAATAACCTC CTCGCCGCCA TGCTCGACAA CCATATCTAC 451 CAAGGTAACGAGTTGAACAT CGACCCCAAA CGCGTGCTGT GGCGGCGCGT 501 GGTCGATATG AACGACCGCCAGTTGCGCAA CATCATCGAC GGTATGGGCA 551 AGCCTGTtga cggCGTGATG CGtcccGACGGCTTCGACAT CACCGTCGCC 601 TCCGAAGTGa tggcgGTATT CTGCCTTGCC AAAGACATCAGCGATTTGAA 651 AGAGCGTTtt gGCAATATTC TCGTCGCCTA CGCCAAAGAC GGCAGCCCCG701 TTTACGCCAA AGATTTGAAG GCACACGGCG CGATGGCGGC ATTGCTAAAA 751GATGCGATTA AGCCCAATTT GGTGCAAACC ATCGAAGGCA CTCCGGCCTT 801 TGTACACGGCGGCCCGTTCG CCAACATCGC CCACGGCTGC AACTCCGTTA 851 CCGCAACCCG TCTGGCGAAACACCTTGCCG ATTACGCCGT AACCGAAGCA 901 GGCTTCGGCG CGGACTTGGG TGCGGAAAAATTCTGCGACA TCAAATGCCG 951 CCTTGCCGGT TTGAAACCTG ATGCGGCAGT CGTCGTGGCGACTGTCCGCG 1001 CCCTGAAATA CAACGGCGGC GTGGAACGCG CCAACCTTGG TGAAGAAAAC1051 CTCGAAGCCT TGGCAAAAGG TTTGCCCAAC CTGTTGAAAC ACATTTCCAA 1101CCTGAAAAAC GTATTCGGAC TGCCCGTCGT CGTTGCGCTC AACCGCTTCG 1151 TGTCCGACTCCGATGCCGAG TTGGCGATGA TTGAAAAAGC CTGTGCCGAA 1201 CACGGCGTTG AAGTTTCCCTGACCGAAGTG TGGGGCAAAG GCGGCGCGGG 1251 CGGCGCGGAT TTGGCGCGCA AAGTCGTCAATGCCATCGAC AACCAACCTA 1301 ATAACTTCGG TTTCGCCTAC GATGTCGAGT TGGGCATCAAAGACAAAATC 1351 CGTGCGATTG CCCAAAAAGT GTACGGCGCG GAAGATGTCG ATTTCAGCGC1401 GGAAGCGTCT GCCGAAATCG CCTCGCTGGA AAAACTGGGC TTGGACAAAA 1451TGCCGATCTG CATGGCGAAA ACCCAATATT CATTGAGCGA CAACGCCAAA 1501 CTCTTGGGCTGCCCCGAAGG CTTCCGCATC GCCGTACGCG GTATCACTGT 1551 TTCCGCCGGC GCGGGCTTCATCGTTGCGTT GTGCGGCAAT ATGATGAAAA 1601 TGCCGGGCCT GCCGAAAGTT CCGGCTGCCGAGAAAATCGA TGTGGACGAA 1651 CACGGCGTGA TTCACGGCTT GTTCTGAThis corresponds to the amino acid sequence <SEQ ID 554; ORF 141.ng>:

g141.pep 1 MSFKTDAETA QSSTMRPIGE IAAKLGLNVD NIEPYGHYKA KINPAEAFKL 51PQKQGRLILV TAINPTPAGE GKTTVTIGLA DALRHIGKDS VIALREPSLG 101 PVFGVKGGAAGGGYAQVLPM EDINLHFTGD FHAIGAANNL LAAMLDNHIY 151 QGNELNIDPK RVLWRRVVDMNDRQLRNIID GMGKPVDGVM RPDGFDITVA 201 SEVMAVFCLA KDISDLKERF GNILVAYAKDGSPVYAKDLK AHGAMAALLK 251 DAIKPNLVQT IEGTPAFVHG GPFANIAHGC NSVTATRLAKHLADYAVTEA 301 GFGADLGAEK FCDIKCRLAG LKPDAAVVVA TVRALKYNGG VERANLGEEN351 LEALAKGLPN LLKHISNLKN VFGLPVVVAL NRFVSDSDAE LAMIEKACAE 401HGVEVSLTEV WGKGGAGGAD LARKVVNAID NQPNNFGFAY DVELGIKDKI 451 RAIAQKVYGAEDVDFSAEAS AEIASLEKLG LDKMPICMAK TQYSLSDNAK 501LLGCPEGFRI AVRGITVSAG AGFIVALCGN MMKMPGLPKV PAAEKIDVDE 551 HGVIHGLF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 555>:

m141.seq 1 ATGAGCTTCA AAACCGATGC CGAAATCGCC CAATCCTCCA CCATGCGCCC 51GATTGGCGAA ATTGCCGCCA AGCTTGGTCT GAATGCCGAC AACATTGAGC 101 CTTACGGTCATTACAAGGCG AAAATCAATC CTGCCGAAGC GTTCAAACTG 151 CCGCAAAAAC AGGGCAGGCTGATTTTGGTT ACCGCCATCA ACCCGACTCC 201 GGCGGGCGAA GGCAAAACCA CCGTAACCATCGGTTTGGCG GACGCGTTGC 251 GCCACATCGG CAAAGATGCC GTGATTGCCC TGCGCGAACCTTCTCTGGGG 301 CCGGTGTTCG GCGTGAAAGG CGGCGCGGCA GGCGGCGGCT ATGCCCAAGT351 TTTGCCGATG GAAGACATCA ACCTGCACTT CACCGGAGAT TTTCACGCCA 401TCGGTGCGGC AAATAATCTG CTTGCCGCGA TGCTCGACAA CCATATCTAC 451 CAAGGCAACGAGTTGAACAT CGACCCCAAA CGCGTGCTGT GGCGGCGCGT 501 GGTCGATATG AACGACCGCCAGTTGCGCAA CATCATCGAC GGCATGGGTA 551 AACCCGTTGA CGGCGTGATG CGTCCTGACGGTTTCGATAT TACCGTTGCT 601 TCCGAAGTGA TGGCGGTATT CTGTCTTGCC AAAGACATCAGCGATTTGAA 651 AGAGCGTTTG GGCAACATCC TTGTCGCCTA CGCCAAAGAC GGCAGCCCCG701 TTTACGCCAA AGATTTGAAA GCGAATGGCG CGATGGCGGC ATTGCTTAAA 751GATGCGATTA AGCCCAACTT GGTGCAAACC ATCGAAGGCA CGCCCGCCTT 801 CGTACACGGCGGCCCGTTCG CCAACATCGC CCACGGCTGC AACTCCGTAA 851 CCGCAACCCG TCTGGCGAAACACCTTGCCG ATTACGCCGT AACCGAAGCA 901 GGCTTCGGCG CGGACTTGGG CGCGGAAAAATTCTGCGACA TCAAATGCCG 951 CCTTGCCGGT TTGAAACCTG ATGCGGCTGT TGTCGTGGCGACTGTCCGCG 1001 CGTTGAAATA TAACGGCGGC GTGGAACGCG CCAACCTCGG CGAAGAAAAT1051 TTAGACGCTT TGGAAAAAGG TTTGCCCAAC CTGCTGAAAC ACATTTCCAA 1101CCTGAAAAAC GTATTCGGAC TGCCCGTCGT CGTTGCGCTC AACCGCTTCG 1151 TGTCCGACGCCGATGCCGAG TTGGCGATGA TTGAAAAAGC CTGTGCCGAA 1201 CACGGCGTTG AAGTTTCCCTGACCGAAGTG TGGGGCAAAG GTGGTGCGGG 1251 CGGCGCGGAT TTGGCGCGCA AAGTCGTCAACGCCATTGAA AGTCAAACCA 1301 ATAACTTCGG TTTCGCCTAC GATGTCGAGT TGGGCATCAAAGACAAAATC 1351 CGTGCGATTG CCCAAAAAGT GTACGGCGCG GAAGATGTTG ATTTCAGCGC1401 GGAAGCGTCT GCCGAAATCG CTTCACTGGA AAAACTGGGC TTGGACAAAA 1451TGCCGATCTG CATGGCGAAA ACCCAATACT CTTTGAGCGA CAACGCCAAA 1501 CTGTTGGGCTGCCCCGAAGA CTTCCGCATC GCCGTGCGCG GCATCACCGT 1551 TTCCGCAGGC GCAGGTTTCATCGTCGCCCT GTGCGGCAAC ATGATGAAAA 1601 TGCCCGGCCT GCCCAAAGTT CCGGCTGCCGAGAAAATCGA TGTGGACGCA 1651 GAAGGCGTGA TTCACGGCTT GTTCTGAThis corresponds to the amino acid sequence <SEQ ID 556; ORF 141>:

m141.pep 1 MSFKTDAEIA QSSTMRPIGE IAAKLGLNAD NIEPYGHYKA KINPAEAFKL 51PQKQGRLILV TAINPTPAGE GKTTVTIGLA DALRHIGKDA VIALREPSLG 101 PVFGVKGGAAGGGYAQVLPM EDINLHFTGD FHAIGAANNL LAAMLDNHIY 151 QGNELNIDPK RVLWRRVVDMNDRQLRNIID GMGKPVDGVM RPDGFDITVA 201 SEVMAVFCLA KDISDLKERL GNILVAYAKDGSPVYAKDLK ANGAMAALLK 251 DAIKPNLVQT IEGTPAFVHG GPFANIAHGC NSVTATRLAKHLADYAVTEA 301 GFGADLGAEK FCDIKCRLAG LKPDAAVVVA TVRALKYNGG VERANLGEEN351 LDALEKGLPN LLKHISNLKN VFGLPVVVAL NRFVSDADAE LAMIEKACAE 401HGVEVSLTEV WGKGGAGGAD LARKVVNAIE SQTNNFGFAY DVELGIKDKI 451 RAIAQKVYGAEDVDFSAEAS AEIASLEKLG LDKMPICMAK TQYSLSDNAK 501LLGCPEDFRI AVRGITVSAG AGFIVALCGN MMKMPGLPKV PAAEKIDVDA 551 EGVIHGLF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 141 shows 97.5% identity over a 558 aa overlap with a predicted ORF(ORF 141.ng) from N. gonorrhoeae:

m141/g141         10        20        30        40        50        60m141.pep MSFKTDAEIAQSSTMRPIGEIAAKLGLNADNIEPYGHYKAKINPAEAFKLPQKQGRLILV|||||||| |||||||||||||||||||:||||||||||||||||||||||||||||||| g141MSFKTDAETAQSSTMRPIGEIAAKLGLNVDNIEPYGHYKAKINPAEAFKLPQKQGRLILV        10        20        30        40        50        60        70        80        90       100       110       120 m141.pepTAINPTPAGEGKTTVTIGLADALRHIGKDAVIALREPSLGPVFGVKGGAAGGGYAQVLPM|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| g141TAINPTPAGEGKTTVTIGLADALRHIGKDSVIALREPSLGPVFGVKGGAAGGGYAQVLPM        70        80        90       100       110       120       130       140       150       160       170       180 m141.pepEDINLHFTGDFHAIGAANNLLAAMLDNHIYQGNELNIDPKRVLWRRVVDMNDRQLRNIID|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g141EDINLHFTGDFHAIGAANNLLAAMLDNHIYQGNELNIDPKRVLWRRVVDMNDRQLRNIID       130       140       150       160       170       180       190       200       210       220       230       240 m141.pepGMGKPVDGVMRPDGFDITVASEVMAVFCLAKDISDLKERLGNILVAYAKDGSPVYAKDLK|||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||| g141GMGKPVDGVMRPDGFDITVASEVMAVFCLAKDISDLKERFGNILVAYAKDGSPVYAKDLK       190       200       210       220       230       240       250       260       270       280       290       300 m141.pepANGAMAALLKDAIKPNLVQTIEGTPAFVHGGPFANIAHGCNSVTATRLAKHLADYAVTEA|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g141AHGAMAALLKDAIKPNLVQTIEGTPAFVHGGPFANIAHGCNSVTATRLAKHLADYAVTEA       250       260       270       280       290       300       310       320       330       340       350       360 m141.pepGFGADLGAEKFCDIKCRLAGLKPDAAVVVATVRALKYNGGVERANLGEENLDALEKGLPN|||||||||||||||||||||||||||||||||||||||||||||||||||:|| ||||| g141GFGADLGAEKFCDIKCRLAGLKPDAAVVVATVRALKYNGGVERANLGEENLEALAKGLPN       310       320       330       340       350       360       370       380       390       400       410       420 m141.pepLLKHISNLKNVFGLPVVVALNRFVSDADAELAMIEKACAEHGVEVSLTEVWGKGGAGGAD||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| g141LLKHISNLKNVFGLPVVVALNRFVSDSDAELAMIEKACAEHGVEVSLIEVWGKGGAGGAD       370       380       390       400       410       420       430       440       450       460       470       480 m141.pepLARKVVNAIESQTNNFGFAYDVELGIKDKIRAIAQKVYGAEDVDFSAEASAEIASLEKLG|||||||||::| ||||||||||||||||||||||||||||||||||||||||||||||| g141LARKVVNAIDNQPNNFGFAYDVELGIKDKIRAIAQKVYGAEDVDFSAEASAEIASLEKLG       430       440       450       460       470       480       490       500       510       520       530       540 m141.pepLDKMPICMAKTQYSLSDNAKLLGCPEDFRIAVRGITVSAGAGFIVALCGNMMKMPGLPKV|||||||||||||||||||||||||| ||||||||||||||||||||||||||||||||| g141LDKMPICMAKTQYSLSDNAKLLGCPEGFRIAVRGITVSAGAGFIVALCGNMMKMPGLPKV       490       500       510       520       530       540       550      559 m141.pep PAAEKIDVDAEGVIHGLFX ||||||||| :||||||||g141 PAAEKIDVDEHGVIHGLFX        550The following partial DNA sequence was identified in N. meningitidis<SEQ ID 557>:

a141.seq 1 ATGAGTTTCA AAACCGATGC CGAAATCGCC CAATCCTCCA CCATGCGCCC 51GATTGGCGAA ATTGCCGCCA AGCTGGGTTT GAACGTTGAC AACATTGAGC 101 CTTACGGTCATTACAAAGCC AAAATCAATC CTGCCGAAGC GTTCAAACTG 151 CCGCAAAAAC AGGGCAGGCTGATTTTGGTT ACCGCCATCA ACCCGACTCC 201 GGCGGGCGAA GGTAAAACCA CCGTAACCATCGGTTTGGCG GACGCATTGC 251 GCCATATCGG CAAAGACTCT GTGATTGCTT TGCGCGAGCCTTCTTTGGGT 301 CCGGTGTTCG GCGTGAAAGG CGGCGCGGCA GGCGGCGGCT ATGCCCAAGT351 TTTGCCGATG GAAGACATCA ACCTGCACTT CACCGGAGAT TTTCACGCCA 401TCGGTGCGGC AAATAATCTG CTTGCCGCGA TGCTCGACAA CCATATCTAC 451 CAAGGCAACGAGTTGAACAT CGACCCCAAA CGCGTGCTGT GGCGGCGCGT 501 GGTCGATATG AACGACCGCCAGTTGCGCAA CATCATCGAC GGCATGGGCA 551 AGCCTGTTGA CGGCGTGATG CGTCCTGACGGTTTCGATAT TACCGTTGCT 601 TCCGAAGTGA TGGCGGTATT CTGTCTTGCC AAAGACATCAGCGATTTGAA 651 AGAGCGTTTG GGCAACATCC TTGTCGCCTA CGCCAAAGAC GGCAGCCCCG701 TTTACGCCAA AGATTTGAAA GCGAATGGCG CGATGGCGGC ATTGCTTAAA 751GATGCGATTA AGCCCAACTT GGTGCAAACC ATCGAAGGCA CGCCCGCCTT 801 CGTACACGGCGGCCCGTTCG CCAACATCGC CCACGGCTGC AACTCCGTAA 851 CCGCAACCCG TCTGGCGAAACACCTTGCCG ATTACGCCGT AACCGAAGCA 901 GGCTTCGGCG CGGACTTGGG CGCGGAAAAATTCTGCGACA TCAAATGCCG 951 CCTTGCCGGT TTGAAACCTG ATGCGGCTGT TGTCGTGGCGACTGTCCGCG 1001 CGTTGAAATA TAACGGCGGC GTGGAACGCG CCAACCTCGG CGAAGAAAAT1051 TTAGACGCTT TGGAAAAAGG TTTGCCCAAC CTGCTGAAAC ACATTTCCAA 1101CCTGAAAAAC GTATTCGGAC TGCCCGTCGT CGTTGCGCTC AACCGCTTCG 1151 TGTCCGACTCCGATGCCGAG TTGGCGATGA TTGAAAAAGC CTGTGCCGAA 1201 CACGGCGTTG AAGTTTCCCTGACCGAAGTG TGGGGCAAAG GTGGTGCGGG 1251 CGGCGCGGAT TTGGCGCGCA AAGTCGTCAACGCCATTGAA AGTCAAACCA 1301 ATAACTTCGG TTTCGCCTAC GATGTCGAGT TGGGCATCAAAGACAAAATC 1351 CGTGCGATTG CCCAAAAAGT GTACGGCGCG GAAGATGTTG ATTTCAGCGC1401 GGAAGCGTCT GCCGAAATCG CTTCACTGGA AAAACTGGGC TTGGACAAAA 1451TGCCGATCTG CATGGCGAAA ACCCAATACT CTTTGAGCGA CAACGCCAAA 1501 CTGTTGGGCTGCCCCGAAGA CTTCCGCATC GCCGTGCGCG GCATCACCGT 1551 TTCCGCAGGC GCAGGTTTCATCGTCGCCCT GTGCGGCAAC ATGATGAAAA 1601 TGCCCGGCCT GCCCAAAGTT CCGGCTGCCGAGAAAATCGA TGTGGACGCA 1651 GAAGGCGTGA TTCACGGCTT GTTCTGAThis corresponds to the amino acid sequence <SEQ ID 558; ORF 141.a>:

a141.pep 1 MSFKTDAEIA QSSTMRPIGE IAAKLGLNVD NIEPYGHYKA KINPAEAFKL 51PQKQGRLILV TAINPTPAGE GKTTVTIGLA DALRHIGKDS VIALREPSLG 101 PVFGVKGGAAGGGYAQVLPM EDINLHFTGD FHAIGAANNL LAAMLDNHIY 151 QGNELNIDPK RVLWRRVVDMNDRQLRNIID GMGKPVDGVM RPDGFDITVA 201 SEVMAVFCLA KDISDLKERL GNILVAYAKDGSPVYAKDLK ANGAMAALLK 251 DAIKPNLVQT IEGTPAFVHG GPFANIAHGC NSVTATRLAKHLADYAVTEA 301 GFGADLGAEK FCDIKCRLAG LKPDAAVVVA TVRALKYNGG VERANLGEEN351 LDALEKGLPN LLKHISNLKN VFGLPVVVAL NRFVSDSDAE LAMIEKACAE 401HGVEVSLTEV WGKGGAGGAD LARKVVNAIE SQTNNFGFAY DVELGIKDKI 451 RAIAQKVYGAEDVDFSAEAS AEIASLEKLG LDKMPICMAK TQYSLSDNAK 501LLGCPEDFRI AVRGITVSAG AGFIVALCGN MMKMPGLPKV PAAEKIDVDA 551 EGVIHGLF*m141/a141 99.5% identity in 558 aa overlap        10        20        30        40        50        60 m141.pepMSFKTDAEIAQSSTMRPIGEIAAKLGLNADNIEPYGHYKAKINPAEAFKLPQKQGRLILV||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||| a141MSFKTDAEIAQSSTMRPIGEIAAKLGLNVDNIEPYGHYKAKINPAEAFKLPQKQGRLILV        10        20        30        40        50        60        70        80        90       100       110       120 m141.pepTAINPTPAGEGKTTVTIGLADALRHIGKDAVIALREPSLGPVFGVKGGAAGGGYAQVLPM|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| a141TAINPTPAGEGKTTVTIGLADALRHIGKDSVIALREPSLGPVFGVKGGAAGGGYAQVLPM        70        80        90       100       110       120       130       140       150       160       170       180 m141.pepEDINLHFTGDFHAIGAANNLLAAMLDNHIYQGNELNIDPKRVLWRRVVDMNDRQLRNIID|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a141EDINLHFTGDFHAIGAANNLLAAMLDNHIYQGNELNIDPKRVLWRRVVDMNDRQLRNIID       130       140       150       160       170       180       190       200       210       220       230       240 m141.pepGMGKPVDGVMRPDGFDITVASEVMAVFCLAKDISDLKERLGNILVAYAKDGSPVYAKDLK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a141GMGKPVDGVMRPDGFDITVASEVMAVFCLAKDISDLKERLGNILVAYAKDGSPVYAKDLK       190       200       210       220       230       240       250       260       270       280       290       300 m141.pepANGAMAALLKDAIKPNLVQTIEGTPAFVHGGPFANIAHGCNSVTATRLAKHLADYAVTEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a141ANGAMAALLKDAIKPNLVQTIEGTPAFVHGGPFANIAHGCNSVTATRLAKHLADYAVTEA       250       260       270       280       290       300       310       320       330       340       350       360 m141.pepGFGADLGAEKFCDIKCRLAGLKPDAAVVVATVRALKYNGGVERANLGEENLDALEKGLPN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a141GFGADLGAEKFCDIKCRLAGLKPDAAVVVATVRALKYNGGVERANLGEENLDALEKGLPN       310       320       330       340       350       360       370       380       390       400       410       420 m141.pepLLKHISNLKNVFGLPVVVALNRFVSDADAELAMIEKACAEHGVEVSLTEVWGKGGAGGAD||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| a141LLKHISNLKNVFGLPVVVALNRFVSDSDAELAMIEKACAEHGVEVSLIEVWGKGGAGGAD       370       380       390       400       410       420       430       440       450       460       470       480 m141.pepLARKVVNAIESQTNNFGFAYDVELGIKDKIRAIAQKVYGAEDVDFSAEASAEIASLEKLG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a141LARKVVNAIESQTNNFGFAYDVELGIKDKIRAIAQKVYGAEDVDFSAEASAEIASLEKLG       430       440       450       460       470       480       490       500       510       520       530       540 m141.pepLDKMPICMAKTQYSLSDNAKLLGCPEDFRIAVRGITVSAGAGFIVALCGNMMKMPGLPKV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a141LDKMPICMAKTQYSLSDNAKLLGCPEDFRIAVRGITVSAGAGFIVALCGNMMKMPGLPKV       490       500       510       520       530       540       550      559 m141.pep PAAEKIDVDAEGVIHGLFX |||||||||||||||||||a141 PAAEKIDVDAEGVIHGLFX        550The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 559>:

g142.seq 1 ATGCGTGCCG ATTTCATGTT TGCCGACAAT ATGCCCGTGC AGGTGCGCCA 51ACGCGCCTTC TATTTCAAGT TGTCCCGTTT TGCCGCGATG CCAAATATGG 101 TAGGCAAACCGCTCTTCGGG CGACAGGCCG GTCAGCCCGG CAAAATGTTC 151 GGCAACATCC TGATGTTCGTCCGCCAGCAT ATTGATGCAG AGgCTGCCGT 201 TTTCCGACAG GATcggaATG AttcgCGCACTCCGGTTTAT GCACAGCATC 251 ACGGTCGGCG GCTCGTCGGT AACCGGCGCA ACCGCCGTCATTGTAATGCC 301 GTAACGCCCT GCCGCACCGT CTGTCGTGAT GACATGAACG CCTGCCGCAC351 AGGATGCCAT CGCATCACGG AACGAAGTTT GAAAAGTTTT CTGCAAATCC 401GCCATTTTTC CCCTTTAAAC CGTCCCCTAT ATAAGAATGC TGCACACAAG 451 GCATCCCCCCATGTGCAGCA GTTCTGAThis corresponds to the amino acid sequence <SEQ ID 560; ORF 142.ng>:

g142.pep 1 MRADFMFADN MPVQVRQRAF YFKLSRFAAM PNMVGKPLFG RQAGQPGKMF 51GNILMFVRQH IDAEAAVFRQ DRNDSRTPVY AQHHGRRLVG NRRNRRHCNA 101 VTPCRTVCRDDMNACRTGCH RITERSLKSF LQIRHFSPLN RPLYKNAAHK 151 ASPHVQQF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 561>:

m142.seq 1 ATGCGTGCCG ATTTCATGTT TGCCGACAAT ATGCCCGTGC AGGTGCGCCA 51ACGCGCCCTC TATTTCAAGT TGTCCCGTTT TGCCGCGATG CCAGATGTGG 101 TAGGCAAACCGCTCTTCGGG CGACAGGCCG GTCAGCCCGG CAAAATGTTC 151 GGCAACATCC TGATGTTCGTCCGCCAGCGT ATTGATGCAG AGGCTGCCGT 201 TTTCCGACAG GATCGGAATG ATTCGCGCACTCCGGTTGAT GCACAGCATC 251 ACGGTCGGCG GCTCGTCGGT AACCGGCGCG ACCGCCGTCATTGTAATGCC 301 GTAACGCCCT GCCGCACCGT CTGTCGTGAT GACATGAACG CCTGCCGCGC351 AAGATGCCAT CGCATCACGG AACGAAGTTT GAAAATTTTT CTGCAAATCC 401GCCATTTTTC CCCTTTAAAC TGTCCCCTAT ATAAGAATGC TGCACACAAG 451 GCATCCCCcCATGTGCAGCA GTTTTGAThis corresponds to the amino acid sequence <SEQ ID 562; ORF 142>:

m142.pep 1 MRADFMFADN MPVQVRQRAL YFKLSRFAAM PDVVGKPLFG RQAGQPGKMF 51GNILMFVRQR IDAEAAVFRQ DRNDSRTPVD AQHHGRRLVG NRRDRRHCNA 101 VTPCRTVCRDDMNACRARCH RITERSLKIF LQIRHFSPLN CPLYKNAAHK 151 ASPHVQQF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 142 shows 93.7% identity over a 158 aa overlap with a predicted ORF(ORF 142.ng) from N. gonorrhoeae:

m142/g142         10        20        30        40        50        60m142.pep MRADFMFADNMPVQVRQRALYFKLSRFAAMPDVVGKPLFGRQAGQPGKMFGNILMFVRQR|||||||||||||||||||:|||||||||||::||||||||||||||||||||||||||: g142MRADFMFADNMPVQVRQRAFYFKLSRFAAMPNMVGKPLFGRQAGQPGKMFGNILMFVRQH        10        20        30        40        50        60        70        80        90       100       110       120 m142.pepIDAEAAVFRQDRNDSRTPVDAQHHGRRLVGNRRDRRHCNAVTPCRTVCRDDMNACRARCH||||||||||||||||||| |||||||||||||:||||||||||||||||||||||: || g142IDAEAAVFRQDRNDSRTPVYAQHHGRRLVGNRRNRRHCNAVTPCRTVCRDDMNACRTGCH        70        80        90       100       110       120       130       140       150      159 m142.pepRITERSLKIFLQIRHFSPLNCPLYKNAAHKASPHVQQFX|||||||| ||||||||||| |||||||||||||||||| g142RITERSLKSFLQIRHFSPLNRPLYKNAAHKASPHVQQFX        130       140       150The following partial DNA sequence was identified in N. meningitidis<SEQ ID 563>:

a142.seq 1 ATGCGTGCCG ATTTCATGTT TGCCGACAAT ATGCCCGTGC AGGTGCGCCA 51ACGCGCCCTC TATTTCAAGT TGTCCCGTTT TGCCGCGATG CCAGATGTGG 101 TAGGCAAACCGCTCTTCGGG CGACAGGCCG GTCAGCCCGG CAAAATGTTC 151 GGCAACATCC TGATGTTCGTCCGCCAGCGT ATTGATGCAG AGGCTGCCGT 201 TTTCCGACAG GATCGGAATG ATTCGCGCACTCCGGTTGAT GCACAGCATC 251 ACGGTCGGCG GCTCGTCCGT AACCGGCGCA ACCGCCGTCATTGTAATGCC 301 GTAACGCCCT GCCGCACCGT CTGTCGTGAT GACATGAACG CCTGCCGCAC351 AGGATGCCAT CGCATCACGG AACGAAGTTT GAAAAGTTTT CTGCAAATCC 401GCCATTTTTC CCCTTTAAAC TGTCCCCTAT ATAAGAATGC TGCACACAAG 451 GCACCCCCCATGTGCAGCAG TTCTGATTCA AAAAGCCGTC GGTCGGACAT 501 TTCCGCGCGT TACGGCGTATTACGAGTTCA ACGCATCCTC GATTTTGGCA 551 AGTTCTGCCA ACAGGTCTTT AAGCAGCAGCATTTTCTCGC GGCCCAGCAC 601 TTCCTCGATA GCGTCGTAAC GCTCGTCCAC TTCTTCGCCGATTTCCTCAT 651 ACAGCTTCTC GCCCTCGGCA GTCAGCTTCA GAAAAACACG TCGTTGGTCG701 TTGGAAGGTT TCAGGCGGAC AACCAAACCC GCTTTTTCAA GGCGGGTCAG 751GATACCGGTC AGGCTGGGGC GCAAAATGCA CGCCTGATTC GCCAAATCTT 801 GAAAGTCCAGCGTGCCGTTT TCCGCCAAAA GACGGATAAT CCGCCATTGC 851 TGATCGGTAA TATTCGCCTGATTCAGAATA GGCCTGAATT GGGTCATCAG 901 GGCTTCCCTT GCCTGTATCA GACCGATATTGATAGACGCA TGTTTTGAThis corresponds to the amino acid sequence <SEQ ID 564; ORF 142.a>:

a142.pep 1 MRADFMFADN MPVQVRQRAL YFKLSRFAAM PDVVGKPLFG RQAGQPGKMF 51GNILMFVRQR IDAEAAVFRQ DRNDSRTPVD AQHHGRRLVR NRRNRRHCNA 101 VTPCRTVCRDDMNACRTGCH RITERSLKSF LQIRHFSPLN CPLYKNAAHK 151 APPMCSSSDS KSRRSDISARYGVLRVQRIL DFGKFCQQVF KQQHFLAAQH 201 FLDSVVTLVH FFADFLIQLL ALGSQLQKNTSLVVGRFQAD NQTRFFKAGQ 251 DTGQAGAQNA RLIRQILKVQ RAVFRQKTDN PPLLIGNIRLIQNRPELGHQ 301 GFPCLYQTDI DRRMF* m142/a142 96.1% identity in 153 aaoverlap         10        20        30        40        50        60m142.pep MRADFMFADNMPVQVRQRALYFKLSRFAAMPDVVGKPLFGRQAGQPGKMFGNILMFVRQR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a142MRADFMFADNMPVQVRQRALYFKLSRFAAMPDVVGKPLFGRQAGQPGKMFGNILMFVRQR        10        20        30        40        50        60        70        80        90       100       110       120 m142.pepIDAEAAVFRQDRNDSRTPVDAQHHGRRLVGNRRDRRHCNAVTPCRTVCRDDMNACRARCH||||||||||||||||||||||||||||| |||:||||||||||||||||||||||: || a142IDAEAAVFRQDRNDSRTPVDAQHHGRRLVRNRRNRRHCNAVTPCRTVCRDDMNACRTGCH        70        80        90       100       110       120       130       140       150      159 m142.pepRITERSLKIFLQIRHFSPLNCPLYKNAAHKASPHVQQFX|||||||| |||||||||||||||||||||| | a142RITERSLKSFLQIRHFSPLNCPLYKNAAHKAPPMCSSSDSKSRRSDISARYGVLRVQRIL       130       140       150       160       170       180 a142DFGKFCQQVFKQQHFLAAQHFLDSVVTLVHFFADFLIQLLALGSQLQKNTSLVVGRFQAD       190       200       210       220       230       240The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 565>:

g143.seq 1 ATGTTGAGCT TCGGCTATCT CGGCGTTCAG ACGGCCTTTA CCCTGCAAAG 51CTCGCAGATG AGCCGCATTT TTCAAACGCT AGGCGCAGAC CCGCACAATT 101 TGGGCTGGTTTTTCATCCTG CCGCCGCTGG CGGGGATGCT GGTTCAGCCG 151 ATAGTGgGCT ACTACTCAGACCGCACTTGG AAGCCGCGCT TGGGCGGCCG 201 CCGCCTGCCG TATCTGCTTT ACGGCACGCTGATTGCGGTC ATCGTGATGA 251 TTTTGATGCC GAACTCGGGC AGCTTCGGTT TCGGCTATGCGTCGCTGGCG 301 GCCTTGTCGT TCGGCGCGCT GATGATTGCG CTGTTGGACG TGTCGTCGAA351 TATGGCGATG CAGCCGTTTA AGATGATGGT CGGCGATATG GTCAACGAGG 401AGCAGAAAAG CTACGCCTAC GGGATTCAAA GTTTCTTAGC GAATACGGAC 451 GCGGTTGTGGCAGCGATTCT GCCGTTTGTG TTcgcgtata TCGGTTTGGC 501 GAACACTGCC GAGAAAGGCGTTGTGCCACA AACCGTGGTC GTAGCATTCT 551 ATGTGGGTGC GGCGTTACTG ATTATTACCAGTGCGTTCAC AATCTCCAAA 601 GTCAAAGAAT ACGACCCGGA AACCTACGCC CGTTACCACGGCATCGATGT 651 CGCCGCGAAT CAGGAAAAAG CCAACTGGTT CGAACTCTTA AAAACCGCGC701 CTAAAGTGTT TTGGACGGTT ACTCCGGTAC AGTTTTTCTG CTGGTTCGCC 751TTCCGGTATA TGTGGACTTA CTCGGCAGGC GCGATTGCAG AAAACGTCTG 801 GCACACTACCGATGCGTCTT CCGTAGGCCA TCAGGAGGCG GGCAACCGGT 851 ACGGCGTTTT GGCGGCGGTGTAGTCGGTTG CGGCGGTGAT TTGTTCGTTT 901 ATTCTGGCAA AAGTACCGAA TAAATACCATAAGGCGGGTT ATTTCGGCTG 951 TTTGGCTTTG GGCGCGCTCG GTTTCTTCTC TATCTTCTTCATCTACAATC 1001 AATACGCACT CATCCTGTCT TATATCTTAA TCGGCATCGC TTGGGCGGGC1051 ATTATCACTT ATCCGCTGAC GATTGTGGCC AACGCTTTGT CGGGCAAACA 1101CATGGATACT TATTTGGGCC TGTttaacgg ctctgtCTGT ATGCcgcaaa 1151 tcgTcgctTCGctgttgAGT TTCGTGCTTT TCCCGATGCT GGGCGGCCAT 1201 CAGGCAACCA TGTTCTTGGTTGCAGGCGCA GTCTTGCTGC TGGGAGCCTT 1251 CTCAGTCTGT CTGATTAAAG AGATCCACGGCGGGGTTTGAThis corresponds to the amino acid sequence <SEQ ID 566; ORF 143.ng>:

g143.pep 1 MLSFGYLGVQ TAFTLQSSQM SRIFQTLGAD PHNLGWFFIL PPLAGMLVQP 51IVGYYSDRTW KPRLGGRRLP YLLYGTLIAV IVMILMPNSG SFGFGYASLA 101ALSFGALMIA LLDVSSNMAM QPFKMMVGDM VNEEQKSYAY GIQSFLANTD 151AVVAAILPFV FAYIGLANTA EKGVVPQTVV VAFYVGAALL IITSAFTISK 201 VKEYDPETYARYHGIDVAAN QEKANWFELL KTAPKVFWTV TPVQFFCWFA 251 FRYMWTYSAG AIAENVWHTTDASSVGHQEA GNRYGVLAAV *SVAAVICSF 301 ILAKVPNKYHKAGYFGCLAL GALGFFSIFF IYNQYALILS YILIGIAWAG 351 IITYPLTIVA NALSGKHMDTYLGLFNGSVC MPQIVASLLS FVLFPMLGGH 401 QATMFLVAGA VLLLGAFSVC LIKEIHGGV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 567>:

m143.seq 1 ATGCTCAGTT TCGGCTTTCT CGGCGTTCAG ACGGCCTTTA CCCTGCAAAG 51CTCGCAAATG AGCCGCATTT TTCAAACGCT AGGCGCAGAC CCGCACAATT 101 TGGGCTGGTTTTTCATCCTG CCGCCGCTGG CGGGGATGCT GGTGCAGCCG 151 ATTGTCGGCC ATTACTCCGACCGCACTTGG AAGCCGCGTT TGGGCGGCCG 201 CCGTCTGCCG TATCTGCTTT ATGGCACGCTGATTGCGGTT ATTGTGATGA 251 TTTTGATGCC GAACTCGGGC AGCTTCGGTT TCGGCTATGCGTCGCTGGCG 301 GCTTTGTCGT TCGGCGCGCT GATGATTGCG CTGTTAGACG TGTCGTCAAA351 TATGGCGATG CAGCCGTTTA AGATGATGGT CGGCGACATG GTCAACGAGG 401AGCAGAAAGG CTACGCCTAC GGGATTCAAA GTTTCTTAGC AAATACGGGC 451 GCGGTCGTGGCGGCGATTCT GCCGTTTGTG TTTGCGTATA TCGGTTTGGC 501 GAACACCGCC GAGAAAGGCGTTGTGCCGCA GACCGTGGTC GTGGCGTTTT 551 ATGTGGGTGC GGCGTTGCTG GTGATTACCAGCGCGTTCAC GATTTTCAAA 601 GTGAAGGAAT ACGATCCGGA AACCTACGCC CGTTACCACGGCATCGATGT 651 CGCCGCGAAT CAGGAAAAAG CCAACTGGAT CGAACTCTTG AAAACCGCGC701 CTAAGGCGTT TTGGACGGTT ACTTTGGTGC AATTCTTCTG CTGGTTCGCC 751TTCCAATATA TGTGGACTTA CTCGGCAGGC GCGATTGCGG AAAACGTCTG 801 GCACACCACCGATGCGTCTT CCGTAGGTTA TCAGGAGGCG GGTAACTGGT 851 ACGGCGTTTT GGCGGCGGTGCAGTCGGTTG CGGCGGTGAT TTGTTCGTTT 901 GTATTGGCGA AAGTGCCGAA TAAATACCATAAGGCGGGTT ATTTCGGCTG 951 TTTGGCTTTG GGCGCGCTCG GCTTTTTCTC CGTTTTCTTCATCGGCAACC 1001 AATACGCGCT GGTGTTGTCT TATACCTTAA TCGGCATCGC TTGGGCGGGC1051 ATTATCACTT ATCCGCTGAC GATTGTGACC AACGCCTTGT CGGGCAAGCA 1101TATGGGCACT TACTTGGGCT TGTTTAACGG CTCTATCTGT ATGCCTCAAA 1151 TCGTCGCTTCGCTGTTGAGT TTCGTGCTTT TCCCTATGCT GGGCGGCTTG 1201 CAGGCCACTA TGTTCTTGGTAGGGGGCGTC GTCCTGCTGC TGGGCGCGTT 1251 TTCCGTGTTC CTGATTAAAG AAACACACGGCGGGGTTTGAThis corresponds to the amino acid sequence <SEQ ID 568; ORF 143>:

m143.pep 1 MLSFGFLGVQ TAFTLQSSQM SRIFQTLGAD PHNLGWFFIL PPLAGMLVQP 51IVGHYSDRTW KPRLGGRRLP YLLYGTLIAV IVMILMPNSG SFGFGYASLA 101ALSFGALMIA LLDVSSNMAM QPFKMMVGDM VNEEQKGYAY GIQSFLANTG 151AVVAAILPFV FAYIGLANTA EKGVVPQTVV VAFYVGAALL VITSAFTIFK 201 VKEYDPETYARYHGIDVAAN QEKANWIELL KTAPKAFWTV TLVQFFCWFA 251 FQYMWTYSAG AIAENVWHTTDASSVGYQEA GNWYGVLAAV QSVAAVICSF 301 VLAKVPNKYHKAGYFGCLAL GALGFFSVFF IGNQYALVLS YTLIGIAWAG 351 IITYPLTIVT NALSGKHMGTYLGLFNGSIC MPQIVASLLS FVLFPMLGGL 401 QATMFLVGGV VLLLGAFSVF LIKETHGGV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m143/g143 93.9% identity in 429 aa overlap        10        20        30        40        50        60 m143.pepMLSFGFLGVQTAFTLQSSQMSRIFQTLGADPHNLGWFFILPPLAGMLVQPIVGHYSDRTW|||||:|||||||||||||||||||||||||||||||||||||||||||||||:|||||| g143MLSFGYLGVQTAFTLQSSQMSRIFQTLGADPHNLGWFFILPPLAGMLVQPIVGYYSDRTW        10        20        30        40        50        60        70        80        90       100       110       120 m143.pepKPRLGGRRLPYLLYGTLIAVIVMILMPNSGSFGFGYASLAALSFGALMIALLDVSSNMAM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g143KPRLGGRRLPYLLYGTLIAVIVMILMPNSGSFGFGYASLAALSFGALMIALLDVSSNMAM        70        80        90       100       110       120       130       140       150       160       170       180 m143.pepQPFKMMVGDMVNEEQKGYAYGIQSFLANTGAVVAAILPFVFAYIGLANTAEKGVVPQTVV||||||||||||||||:|||||||||||| |||||||||||||||||||||||||||||| g143QPFKMMVGDMVNEEQKSYAYGIQSFLANTDAVVAAILPFVFAYIGLANTAEKGVVPQTVV       130       140       150       160       170       180       190       200       210       220       230       240 m143.pepVAFYVGAALLVITSAFTIFKVKEYDPETYARYHGIDVAANQEKANWIELLKTAPKAFWTV||||||||||:||||||| |||||||||||||||||||||||||||:||||||||:|||| g143VAFYVGAALLIITSAFTISKVKEYDPETYARYHGIDVAANQEKANWFELLKTAPKVFWTV       190       200       210       220       230       240       250       260       270       280       290       300 m143.pepTLVQFFCWFAFQYMWTYSAGAIAENVWHTTDASSVGYQEAGNWYGVLAAVQSVAAVICSF| |||||||||:||||||||||||||||||||||||:||||| ||||||| ||||||||| g143TPVQFFCWFAFRYMWTYSAGAIAENVWHTTDASSVGHQEAGNRYGVLAAVXSVAAVICSF       250       260       270       280       290       300       310       320       330       340       350       360 m143.pepVLAKVPNKYHKAGYFGCLALGALGFFSVFFIGNQYALVLSYTLIGIAWAGIITYPLTIVT:||||||||||||||||||||||||||:||| |||||:||| |||||||||||||||||: g143ILAKVPNKYHKAGYFGCLALGALGFFSIFFIYNQYALILSYILIGIAWAGIITYPLTIVA       310       320       330       340       350       360       370       380       390       400       410       420 m143.pepNALSGKHMGTYLGLFNGSICMPQIVASLLSFVLFPMLGGLQATMFLVGGVVLLLGAFSVF|||||||| |||||||||:|||||||||||||||||||| |||||||:|:||||||||| g143NALSGKHMDTYLGLFNGSVCMPQIVASLLSFVLFPMLGGHQATMFLVAGAVLLLGAFSVC       370       380       390       400       410       420        430m143.pep LIKETHGGVX |||| ||||| g143 LIKEIHGGVX        430The following partial DNA sequence was identified in N. meningitidis<SEQ ID 569>:

a143.seq 1 ATGCTCAGTT TCGGCTTTCT CGGCGTTCAG ACGGCCTTTA CCCTGCAAAG 51CTCGCAGATG AGCCGCATCT TCCAGACGCT CGGTGCCGAT CCGCACAGCC 101 TCGGCTGGTTCTTTATCCTG CCGCCGCTGG CGGGGATGCT GGTGCAGCCG 151 ATTGTCGGCC ATTACTCCGACCGCACTTGG AAGCCGCGTT TGGGCGGCCG 201 CCGTCTGCCG TATCTGCTTT ATGGCACGCTGATTGCGGTT ATTGTGATGA 251 TTTTGATGCC GAACTCGGGC AGCTTCGGTT TCGGCTATGCGTCGCTGGCG 301 GCTTTGTCGT TCGGCGCGCT GATGATTGCG CTGTTAGACG TGTCGTCAAA351 TATGGCGATG CAGCCGTTTA AGATGATGGT CGGCGACATG GTCAACGAGG 401AGCAGAAAGG CTACGCCTAC GGGATTCAAA GTTTCTTAGC GAATACGGGC 451 GCGGTCGTGGCGGCGATTCT GCCGTTTGTG TTTGCGTATA TCGGTTTGGC 501 GAACACCGCC GAGAAAGGCGTTGTGCCGCA GACCGTGGTC GTGGCGTTTT 551 ATGTGGGTGC GGCGTTGCTG GTGATTACCAGCGCGTTCAC GATTTTCAAA 601 GTGAAGGAAT ACAATCCGGA AACCTACGCC CGTTACCACGGCATCGATGT 651 CGCCGCGAAT CAGGAAAAAG CCAACTGGAT CGAACTCTTG AAAACCGCGC701 CTAAGGCGTT TTGGACGGTT ACTTTGGTGC AATTCTTCTG CTGGTTCGCC 751TTCCAATATA TGTGGACTTA CTCGGCAGGC GCGATTGCGG AAAACGTCTG 801 GCACACCACCGATGCGTCTT CCGTAGGTTA TCAGGAGGCG GGTAACTGGT 851 ACGGCGTTTT GGCGGCGGTGCAGTCGGTTG CGGCGGTGAT TTGTTCGTTT 901 GTATTGGCGA AAGTGCCGAA TAAATACCATAAGGCGGGTT ATTTCGGCTG 951 TTTGGCTTTG GGCGCGCTCG GCTTTTTCTC CGTTTTCTTCATCGGCAACC 1001 AATACGCGCT GGTGTTGTCT TATACCTTAA TCGGCATCGC TTGGGCGGGC1051 ATTATCACTT ATCCGCTGAC GATTGTGACC AACGCCTTGT CGGGCAAGCA 1101TATGGGCACT TACTTGGGCC TGTTTAACGG CTCTATCTGT ATGCCGCAAA 1151 TCGTCGCTTCGCTGTTGAGT TTCGTGCTTT TCCCTATGCT GGGCGGCTTG 1201 CAGGCCACTA TGTTCTTGGTAGGGGGCGTC GTCCTGCTGC TGGGCGCGTT 1251 TTCCGTGTTC CTGATTAAAG AAACACACGGCGGGGTTTGAThis corresponds to the amino acid sequence <SEQ ID 570; ORF 143.a>:

a143.pep 1 MLSFGFLGVQ TAFTLQSSQM SRIFQTLGAD PHSLGWFFIL PPLAGMLVQP 51IVGHYSDRTW KPRLGGRRLP YLLYGTLIAV IVMILMPNSG SFGFGYASLA 101ALSFGALMIA LLDVSSNMAM QPFKMMVGDM VNEEQKGYAY GIQSFLANTG 151AVVAAILPFV FAYIGLANTA EKGVVPQTVV VAFYVGAALL VITSAFTIFK 201 VKEYNPETYARYHGIDVAAN QEKANWIELL KTAPKAFWTV TLVQFFCWFA 251 FQYMWTYSAG AIAENVWHTTDASSVGYQEA GNWYGVLAAV QSVAAVICSF 301 VLAKVPNKYHKAGYFGCLAL GALGFFSVFF IGNQYALVLS YTLIGIAWAG 351 IITYPLTIVT NALSGKHMGTYLGLFNGSIC MPQIVASLLS FVLFPMLGGL 401 QATMFLVGGV VLLLGAFSVF LIKETHGGV*m143/a143 99.5% identity in 429 aa overlap        10        20        30        40        50        60 m143.pepMLSFGFLGVQTAFTLQSSQMSRIFQTLGADPHNLGWFFILPPLAGMLVQPIVGHYSDRTW||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||| a143MLSFGFLGVQTAFTLQSSQMSRIFQTLGADPHSLGWFFILPPLAGMLVQPIVGHYSDRTW        10        20        30        40        50        60        70        80        90       100       110       120 m143.pepKPRLGGRRLPYLLYGTLIAVIVMILMPNSGSFGFGYASLAALSFGALMIALLDVSSNMAM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a143KPRLGGRRLPYLLYGTLIAVIVMILMPNSGSFGFGYASLAALSFGALMIALLDVSSNMAM        70        80        90       100       110       120       130       140       150       160       170       180 m143.pepQPFKMMVGDMVNEEQKGYAYGIQSFLANTGAVVAAILPFVFAYIGLANTAEKGVVPQTVV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a143QPFKMMVGDMVNEEQKGYAYGIQSFLANTGAVVAAILPFVFAYIGLANTAEKGVVPQTVV       130       140       150       160       170       180       190       200       210       220       230       240 m143.pepVAFYVGAALLVITSAFTIFKVKEYDPETYARYHGIDVAANQEKANWIELLKTAPKAFWTV||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||| a143VAFYVGAALLVITSAFTIFKVKEYNPETYARYHGIDVAANQEKANWIELLKTAPKAFWTV       190       200       210       220       230       240       250       260       270       280       290       300 m143.pepTLVQFFCWFAFQYMWTYSAGAIAENVWHTTDASSVGYQEAGNWYGVLAAVQSVAAVICSF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a143TLVQFFCWFAFQYMWTYSAGAIAENVWHTTDASSVGYQEAGNWYGVLAAVQSVAAVICSF       250       260       270       280       290       300       310       320       330       340       350       360 m143.pepVLAKVPNKYHKAGYFGCLALGALGFFSVFFIGNQYALVLSYTLIGIAWAGIITYPLTIVT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a143VLAKVPNKYHKAGYFGCLALGALGFFSVFFIGNQYALVLSYTLIGIAWAGIITYPLTIVT       310       320       330       340       350       360       370       380       390       400       410       420 m143.pepNALSGKHMGTYLGLFNGSICMPQIVASLLSFVLFPMLGGLQATMFLVGGVVLLLGAFSVF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a143NALSGKHMGTYLGLFNGSICMPQIVASLLSFVLFPMLGGLQATMFLVGGVVLLLGAFSVF       370       380       390       400       410       420        430m143.pep LIKETHGGVX |||||||||| a143 LIKETHGGVX        430The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 571>:

g144.seq 1 ATGAGCGATA CCCCCGCTAC CCGCGATTTC GGCCTGATCG ACGGGCGGGC 51CGTAACCGGC TATGTGCTGT CCAACCGGCG TGGTACGTGC GTCTTCGTGC 101 TGGACTTGGGCGGGATTGTG CAGGAATTTT CCGTTTTGGC AGACGGCGTG 151 CGCGAAAACC CCGTGGTGTCGTTCGACGAT GCGGCTTCCT ATGCGGACAA 201 TCCGTTTCAG ATTAACAAGC AGATAGGGCGCGTGGCCGGA CGCATCCGCG 251 GTGCGGCGTT CGACATCAAC GGTAGGACTT ACCGCGTGGAGGCCAACGAA 301 GGCAGGAACG CGCTGCACGG CGGTTCGCAC GGGCTGGCCG TTACCcgtTT351 CAACGCGGTG GCGGCAGACG GccgacggTt atCCCAACGA TTTGGatatT 401TCctaccgCT TGGACGAGGA CGGCCGGCTT ACCGTtaccT ATCGCGCCAC 451 CGCgctCGGCGACACGGTGT TCGACCCGAC GCTGCACATT TACTGGCGGC 501 TGGACGCGGG CCTGCACGATGCGGTTCTGC ATATTCCGCA GGGCGGACAT 551 ATTCCGGCCG ATGCCGAAAA ACTGCCCGTCTTAACGGTTT CAGACGGCCT 601 CGAAGTATTT GAThis corresponds to the amino acid sequence <SEQ ID 572; ORF 144.ng>:

g144.pep 1 MSDTPATRDF GLIDGRAVTG YVLSNRRGTC VFVLDLGGIV QEFSVLADGV 51RENPVVSFDD AASYADNPFQ INKQIGRVAG RIRGAAFDIN GRTYRVEANE 101 GRNALHGGSHGLAVTRFNAV AADGRRLSQR FGYFLPLGRG RPAYRYLSRH 151 RARRHGVRPD AAHLLAAGRGPARCGSAYSA GRTYSGRCRK TARLNGFRRP 201 RSI*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 573>:

m144.seq 1 ATGAGCGATA CCCCCGCTAC CCGCGATTTC GGTCTGATCG ACGGGCGTGC 51CGTAACCGGC TATGTGCTGT CCAACCGGCG TGGTACGCGT GTCTGCGTGC 101TGGACTTGGG CGGGATTGTG CAGGAATTTT CCGTTTTGGC AGACGGCGTG 151CGCGAAAACC TCGTGGTGTC GTTCGATGAT GCGGCTTCCT ATGCGGACAA 201TCCGTTTCAG ATTAACAAAC AGATAGGGCG CGTGGCCGGA CGCATCCGCG 251GTGCGGCGTT CGACATCAAC GGCAGGACTT ACCGCGTGGA GGCCAACGAA 301GGCAGGAACG CGCTGCACGG CGGTTCGCAC GGGCTGGCCG TTACCCGTTT 351CAACGCGGTG GCGGCAGACG GCCGTTCGGT GGTGCTGCGC AGCCGCCTGg 401CAACAGTCGG CCGACGGTTA TCCCAACGAT TTGGATTTGG ATATTTCCTA 451CCGCTTGGAC GAGGACGACC GGCTTACCGT TAcCTATCGC GCCACCGCGC 501TCGGCGACAC GGTGTTCGAC CCGACGCTGC ACATTTACTG GCGGCTGGAC 551GCGGGCCTGC ACGATGCGGT TCTGCATATT CCGCAGGGCG GACATATGCC 601GGCCGATGCC GAAAAACTGC CCGTCTCAAC GGTTTCAGAC GACCTCGAAG 651 TATTTGAThis corresponds to the amino acid sequence <SEQ ID 574; ORF 144>:

m144.pep 1 MSDTPATRDF GLIDGRAVTG YVLSNRRGTR VCVLDLGGIV QEFSVLADGV 51RENLVVSFDD AASYADNPFQ INKQIGRVAG RIRGAAFDIN GRTYRVEANE 101GRNALHGGSH GLAVTRFNAV AADGRSVVLR SRLATVGRRL SQRFGFGYFL 151PLGRGRPAYR YLSRHRARRH GVRPDAAHLL AAGRGPARCG SAYSAGRTYA 201GRCRKTARLN GFRRPRSI*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m144/g144 91.3% identity in 218 aa overlap        10        20        30        40        50        60 m144.pepMSDTPATRDFGLIDGRAVTGYVLSNRRGTRVCVLDLGGIVQEFSVLADGVRENLVVSFDD||||||||||||||||||||||||||||| | ||||||||||||||||||||| |||||| g144MSDTPATRDFGLIDGRAVTGYVLSNRRGTCVFVLDLGGIVQEFSVLADGVRENPVVSFDD        10        20        30        40        50        60        70        80        90       100       110       120 m144.pepAASYADNPFQINKQIGRVAGRIRGAAFDINGRTYRVEANEGRNALHGGSHGLAVTRFNAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g144AASYADNPFQINKQIGRVAGRIRGAAFDINGRTYRVEANEGRNALHGGSHGLAVTRFNAV        70        80        90       100       110       120       130       140       150       160       170       180 m144.pepAADGRSVVLRSRLATVGRRLSQRFGFGYFLPLGRGRPAYRYLSRHRARRHGVRPDAAHLL |||            |||||||||  ||||||||||||||||||||||||||||||||| g144AAD-------------GRRLSQRFG--YFLPLGRGRPAYRYLSRHRARRHGVRPDAAHLL                    130         140       150       160       190       200       210      219 m144.pepAAGRGPARCGSAYSAGRTYAGRCRKTARLNGFRRPRSIX|||||||||||||||||||:||||||||||||||||||| g144AAGRGPARCGSAYSAGRTYSGRCRKTARLNGFRRPRSIX  170       180       190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 575>:

a144.seq 1 ATGAGCGATA CCCCCGCTAC CCGCGATTTC GGCCTGATCG ACGGGCGTGC 51CGTAACCGGC TATGTGCTGT CCAACCGGCG TGGTACGCGT GTCTGCGTGC 101TGGACTTGGG CGGGATTGTG CAGGAATTTT CCGTTTTGGC AGACGGCGTG 151CGCGAAAACC TCGTGGTGTC GTTCGACGAT GCGGCTTCCT ATGCGGACAA 201TCCGTTTCAG ATTAACAAGC AGATAGGGCG CGTGGCCGGA CGCATCCGCG 251GTGCGGCGTT CGACATCAAC GGCAGGACTT ACCGCGTGGA GGCCAACGAA 301GGCAGGAACG CGCTGCACGG CGGTTCGCAC GGGCTGGCCG TTACCCGTTT 351CAACGCGGTG GCGGCAGACG GCCGTTCGGT GGTGCTGCGC AGCCGCCTG. 401CAACAGTCGG CCGACGGTTA TCCCAACGAT TTGGATTTGG ATATTTCCTA 451CCGCTTGGAC GAGGACGACC GGCTTACCGT TACCTATCGC GCCACCGCGC 501TCGGCGACAC GGTGTTCGAC CCGACGCTGC ACATTTACTG GCGGCTGGAC 551GCGGGCCTGC ACGATGCGGT TCTGCATATT CCGCAGGGCG GACATATTCC 601GGCCGATGCC GAAAAACTGC CCGTCTCAAC GGTTTCAGAC GACCTCGAAG 651 TATTTGAThis corresponds to the amino acid sequence <SEQ ID 576; ORF 144.a>:

a144.pep 1 MSDTPATRDF GLIDGRAVTG YVLSNRRGTR VCVLDLGGIV QEFSVLADGV 51RENLVVSFDD AASYADNPFQ INKQIGRVAG RIRGAAFDIN GRTYRVEANE 101GRNALHGGSH GLAVTRFNAV AADGRSVVLR SRLXTVGRRL SQRFGFGYFL 151PLGRGRPAYR YLSRHRARRH GVRPDAAHLL AAGRGPARCG SAYSAGRTYS 201GRCRKTARLN GFRRPRSI* m144/a144 99.1% identity in 218 aa overlap        10        20        30        40        50        60 m144.pepMSDTPATRDFGLIDGRAVTGYVLSNRRGTRVCVLDLGGIVQEFSVLADGVRENLVVSFDD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a144MSDTPATRDFGLIDGRAVTGYVLSNRRGTRVCVLDLGGIVQEFSVLADGVRENLVVSFDD        10        20        30        40        50        60        70        80        90       100       110       120 m144.pepAASYADNPFQINKQIGRVAGRIRGAAFDINGRTYRVEANEGRNALHGGSHGLAVTRFNAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a144AASYADNPFQINKQIGRVAGRIRGAAFDINGRTYRVEANEGRNALHGGSHGLAVTRFNAV        70        80        90       100       110       120       130       140       150       160       170       180 m144.pepAADGRSVVLRSRLATVGRRLSQRFGFGYFLPLGRGRPAYRYLSRHRARRHGVRPDAAHLL||||||||||||| |||||||||||||||||||||||||||||||||||||||||||||| a144AADGRSVVLRSRLXTVGRRLSQRFGFGYFLPLGRGRPAYRYLSRHRARRHGVRPDAAHLL       130       140       150       160       170       180       190       200       210      219 m144.pepAAGRGPARCGSAYSAGRTYAGRCRKTARLNGFRRPRSIX|||||||||||||||||||:||||||||||||||||||| a144AAGRGPARCGSAYSAGRTYSGRCRKTARLNGFRRPRSIX        190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 577>:

g146.seq 1 ATGAAGCAAA TCCCCCTCCG CCTTCTCCAG GTCGTCATTG ACCACGACAA 51AGTCGAACAA TACGGACTGT TCGATTTCAT GCCTTGCCTT CGACAGCCTC 101CTTTGGATAa ctTCCCGACT GTCCGTCCCG CGCcctTTGA GGCGCGCGGC 151AAGCACGTCG AAAGAAGGCG GCAGGATAAA GATACCGACA GCTTCCGGCA 201GCGCGTTGCG AACCTGCGCC GCGCCCTGAA CGTCGATTTC CAAAATCACG 251TCATAGCCTG CCGCCGCCAA CGCATTCACG CCCTCCGTGC TTGTGCCGTA 301ATAGTTGCCG AATACGTCTG CGTATTCCAA AAAAGCCTCC TGCGCGATAA 351GCGATTCAAA CTCTTCTTTG GAAACAAAGT GATAATGTAC GCCGTTTGCT 401TCGCCTTCAC GCGGCGGGCG CGTCGTATGC GACACGGAAA CGCGCAAACC 451GTTATGGTTT GCCAACAGCC GCGACACCAG CGTGGTTTTG CCCGTGCCGG 501AAGCGGCCGA AATGATAAAG ATGTTGCCTT TTCGATAAGC GGACATATTT 551TTTACCTGTA TATTTTCCAA CCGATTGTAT CACAACGGAC ACCCTATTTC 601ATATTTGCCG ATGCCCATAT TTTGCCGCTA TTGTTTTGAThis corresponds to the amino acid sequence <SEQ ID 578; ORF 146.ng>:

g146.pep 1 MKQIPLRLLQ VVIDHDKVEQ YGLFDFMPCL RQPPLDNFPT VRPAPFEARG 51KHVERRRQDK DTDSFRQRVA NLRRALNVDF QNHVIACRRQ RIHALRACAV 101IVAEYVCVFQ KSLLRDKRFK LFFGNKVIMY AVCFAFTRRA RRMRHGNAQT 151VMVCQQPRHQ RGFARAGSGR NDKDVAFSIS GHIFYLYIFQ PIVSQRTPYF 201IFADAHILPL LF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 579>:

m146.seq 1 ATGGCGCAAA TCCTCCTCCG CTCGCGCCAA GTCGTCATTG ACCACGACAA 51AGTCAAACAA TACGGACTGC TCGATTTCAT GCCTTGCCTT CGACAGCCTC 101CTTTGGATAA CTTCCCGACT GTCCGTCCCG CGTCCGTTGA GGCGCGCGGC 151AAGTACGTCG AAAGAAGGCG GCAGGATAAA GATGCCGACG GCTTCGGGCA 201GCGCGTCGCG AACCTGCGCC GCGCCCTGAA CGTCGATTTC CAAAATCACG 251TCATAGCCTG CCGCCGCCAA CGCATTCACA CCCTCCGCGC CTGTGCCGTA 301ATAGTTGCCA AATACGTCGG CGTATTCCAA AAAAGCTTCC TGCGCGATAA 351GCGACTCAAA CTCTTCTTTG GAAACAAAGT GATAATGTAC GCCGTTTGCT 401TCGCCTTCAC GCGGCGGGCG CGTCGTGTGC GACACGGAAA CGCGCAAACC 451GTTATGGTTT GCCAACAGCC GCGACACCAG CGTGGTTTTG CCCGTGCCGG 501AAGCGGCCGA AATGATAAAG ATGTTGCCTT TTCGATAAGC GGACATATTT 551TTTACCTGTA TATTTTCCAG CCGATTGTAT CACAATGGAC ACCCAGTTTC 601CTATTTGCCG ATGCCCATAT TTTGCCGCTA TTGTTTTGAThis corresponds to the amino acid sequence <SEQ ID 580; ORF 146>:

m146.pep 1 MAQILLRSRQ VVIDHDKVKQ YGLLDFMPCL RQPPLDNFPT VRPASVEARG 51KYVERRRQDK DADGFGQRVA NLRRALNVDF QNHVIACRRQ RIHTLRACAV 101IVAKYVGVFQ KSFLRDKRLK LFFGNKVIMY AVCFAFTRRA RRVRHGNAQT 151VMVCQQPRHQ RGFARAGSGR NDKDVAFSIS GHIFYLYIFQ PIVSQWTPSF 201LFADAHILPL LF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m146/g146 90.1% identity in 212 aa overlap        10        20        30        40        50        60 m146.pepMAQILLRSRQVVIDHDKVKQYGLLDFMPCLRQPPLDNFPTVRPASVEARGKYVERRRQDK | || || |||||||||:||||:||||||||||||||||||||  |||||:|||||||| g146MKQIPLRLLQVVIDHDKVEQYGLFDFMPCLRQPPLDNFPTVRPAPFEARGKHVERRRQDK        10        20        30        40        50        60        70        80        90       100       110       120 m146.pepDADGFGQRVANLRRALNVDFQNHVIACRRQRIHTLRACAVIVAKYVGVFQKSFLRDKRLK |:|:||||||||||||||||||||||||||||:|||||||||:|| |||||:|||||:| g146DTDSFRQRVANLRRALNVDFQNHVIACRRQRIHALRACAVIVAEYVCVFQKSLLRDKRFK        70        80        90       100       110       120       130       140       150       160       170       180 m146.pepLFFGNKVIMYAVCFAFTRRARRVRHGNAQTVMVCQQPRHQRGFARAGSGRNDKDVAFSIS||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||| g146LFFGNKVIMYAVCFAFTRRARRMRHGNAQTVMVCQQPRHQRGFARAGSGRNDKDVAFSIS       130       140       150       160       170       180       190       200       210 m146.pepGHIFYLYIFQPIVSQWTPSFLFADAHILPLLFX ||||||||||||||| || |:|||||||||||| g146GHIFYLYIFQPIVSQRTPYFIFADAHILPLLFX        190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 581>:

a146.seq 1 ATGGCGCAAA TCCTCCTCCG CCCGCGCCAA GTCATCATTG ACCACGACAA 51AATCGAACAA TACGGACTGT TCGATTTCAT GCCTTGCCTT CGACAGCCTC 101CTTTGGATAA CTTCCCGACT GTCCGTCCCG CGTCCGTTGA GACGCGCAGC 151AAGCACATCG AAAGACGGCG GCAGGATAAA GATGCCGACG GCTTCGGGCA 201GCGCATCTCG AACCTGAGCC GCGCCCTGAA CGTCGATTTC CAAAATCACG 251TCATAACCTG CCGCCGCCAA CGCATTCACA CCCTCCGCGC TTGTGCCGTA 301ATAGTTGCCG AACACGTCCG CGTATTCCAA AAAAGCCTCC TGCGCGATAA 351GCGACTCAAA CTCTTCTTTG GAAACAAAGT GATAATGTAC GCCGTTTGCT 401TCGCCTTCAC GCGGCGGACG CGTCGTGTGC GACACGGAAA CGCGCAAACC 451GTTATGGTTT GCCAACAGCC GCGACACCAG CGTGGTTTTG CCCGTGCCGG 501AAGCGGCCGA AATGATAAAG ATGTTGCCTT TTCGATAAGC GGACATATTT 551TTTACCTGTA TATTTTCCAG CCGATTGTAT CACAACGGAC ACCCGGTTTC 601CTATTTGCCG ATGCCCATAT TTTGCCGCTA TTGTTTTGAThis corresponds to the amino acid sequence <SEQ ID 582; ORF 146.a>:

a146.pep 1 MAQILLRPRQ VIIDHDKIEQ YGLFDFMPCL RQPPLDNFPT VRPASVETRS 51KHIERRRQDK DADGFGQRIS NLSRALNVDF QNHVITCRRQ RIHTLRACAV 101IVAEHVRVFQ KSLLRDKRLK LFFGNKVIMY AVCFAFTRRT RRVRHGNAQT 151VMVCQQPRHQ RGFARAGSGR NDKDVAFSIS GHIFYLYIFQ PIVSQRTPGF 201LFADAHILPL LF* m146/a146 90.6% identity in 212 aa overlap        10        20        30        40        50        60 m146.pepMAQILLRSRQVVIDHDKVKQYGLLDFMPCLRQPPLDNFPTVRPASVEARGKYVERRRQDK ||||||||||:|||||::||||:|||||||||||||||||||||||:|:|::||||||| a146MAQILLRPRQVIIDHDKIEQYGLFDFMPCLRQPPLDNFPTVRPASVETRSKHIERRRQDK        10        20        30        40        50        60        70        80        90       100       110       120 m146.pepDADGFGQRVANLRRALNVDFQNHVIACRRQRIHTLRACAVIVAKYVGVFQKSFLRDKRLK||||||||::|| ||||||||||||:|||||||||||||||||::| |||||:||||||| a146DADGFGQRISNLSRALNVDFQNHVITCRRQRIHTLRACAVIVAEHVRVFQKSLLRDKRLK        70        80        90       100       110       120       130       140       150       160       170       180 m146.pepLFFGNKVIMYAVCFAFTRRARRVRHGNAQTVMVCQQPRHQRGFARAGSGRNDKDVAFSIS|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||| a146LFFGNKVIMYAVCFAFTRRTRRVRHGNAQTVMVCQQPRHQRGFARAGSGRNDKDVAFSIS       130       140       150       160       170       180       190       200       210 m146.pepGHIFYLYIFQPIVSQWTPSFLFADAHILPLLFX ||||||||||||||| ||:|||||||||||||| a146GHIFYLYIFQPIVSQRTPGFLFADAHILPLLFX        190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 583>:

g147.seq (partial) 1..ATGCGACGAG AAGCCAAAAT GGCACAAATC ACACTCAAAC CCATTGTTTT 51  ATCAATTCTT TTAATCAACA CACCCCTCCT CGCCCAAGCG CATGAAACTG 101  AGCAATCGGT GGGCTTGGAA ACGGTCAGCG TCGTCGGCAA AAGCCGTCCG 151  CGCGCGACTT CGGGGCTGCT GCACACTTCG ACCGCCTCCG ACAAAATCAT 201  CTCCGGCGAT ACTTTGCGCC AAAAAGCCGT CAACTTGGGC GACGCTTTGG 251  ACGGCGTACC GGGCATCCAC GCTTCGCAAT ACGGCGGCGG CGCATCCGCT 301  CCCGTTATTC GCGGTCAAAC GGGCAGACGG ATTAAAGTAT TGAACCATCA 351  CGGCGAAACG GGCGATATGG CGGACTTTTC TCCCGATCAC GCCATTATGG 401  TAGATACCGC CTTGTCGCAA CAGGTTGAAA TCCTGCGCGG GCCGGTTACG 451  CTCTTGTACA GCTCGGgcaa tgtggccgGG GCTGGtcaat gttgccgatg 501  gAAAAAtccc ccaaaaAAtg cc..This corresponds to the amino acid sequence <SEQ ID 584; ORF 147.ng>:

g147.pep (partial) 1..MRREAKMAQI TLKPIVLSIL LINTPLLAQA HETEQSVGLE TVSVVGKSRP 51  RATSGLLHTS TASDKIISGD TLRQKAVNLG DALDGVPGIH ASQYGGGASA 101  PVIRGQTGRR IKVLNHHGET GDMADFSPDH AIMVDTALSQ QVEILRGPVT 151  LLYSSGNVAG AGQCCRWKNP PKNA..The following partial DNA sequence was identified in N. meningitidis<SEQ ID 585>:

m147.seq (partial) 1..CCGCATAAAA CTGAGCAATC GGTGGATTTG GAAACGGTCA GCGTCGTCGG 51  CAAAAGCCGT CCGCGCGCCA CGTCGGGGCT GTTGCACACT TCGACCGCCT 101  CCGACAAAAT CATCTCCGGC GATACCTTGC GCCAAAAAGC CGTCAACTTG 151  GGCGACGCTT TAGACGGCGT ACCGGGCATC CACGCTTCGC AATACGGCGG 201  CGGCGCGTCT GCTCCCGTCA TTCGCGGTCA AACAGGCAGG CGGATTAAAG 251  TGTTGAACCA TCACGGCGAA ACAGGCGATA TGGCGGATTT TTCGCCCGAT 301  CACGCCATTA TGGTAGATAC CGCCTTGTCG CAACAGGTCG AAATCCTGCG 351  CGGGCCGGTT ACGCTCTTGT ACAGCTCGGG CAATGTGGCG GGGCTGGTCG 401  ATGTTGCCGA TGGCAAAATC CCCGAAAAAA TGCCTGAAAA CGGCGTATCG 451  GGCGAACTCG GATTGCGTTT GAGCAGCGGC AATCTGGAAA AACTCACGTC 501  CGGCGGCATC AATATCGGTT TGGGCAAAAA CTTTGTATTG CACACGGAAG 551  GGCTGTACCG CAAATCGGGG GATTACGCCG TACCGCGTTA CCGCAATCTG 601  AAACGCCTGC CCGACAGCCA CGCCGATTCG CAAACGGGCA GCATCGGGCT 651  GTCTTGGGTT GGCGAAAAAG GTTTTATCGG CGTAGCGTAC AGCGACCGTC 701  GCGACCAATA TGGTCTGCCT GCCCACAGCC ACGAATACGA TGATTGCCAC 751  GCCGACATCA TCTGGCAAAA GAGCTTGATT AACAAACGCT ATTTACAGCT 801  TTATCCGCAC CTGTTGACCG AAGAAGACAT CGATTACGAC AATCCGGGCT 851  TGAGCTGCGG CTTCCACGAC GACGATAATG CACACGCACA CACCCACAGC 901  GGCAGACCGT GGATAGACCT GCGCAACAAA CGCTACGAAC TCCGTGCCGA 951  ATGGAAGCAA CCGTTCCCCG GTTTTGAAGC CCTGCGCGTA CACCTGAACC 1001  GCAACGACTA CCGCCACGAC GAAAAAGCAG GCGATGCAGT CGAAAACTTT 1051  TTTAACAACC AAACGCAAAA CGGCGGCATC GAGTTGCGCC ACCAACCCAT 1101  AGGTCGTCTG AAAGGCAGCT GGGGCGTGCA ATATTTACAA CAAAAATCCA 1151  GTGCTTTATC TGCCATATCC GAAGCGGTTA AACAACCGAT GCTGCTTGAC 1201  AACAAAGTGC AACATTACAG CTTTTTCGGT GTAGAACAGG CAAACTGGGA 1251  CAACTTCACG CTTGAAGGAG GCGTACGCGT GGAAAAACAA AAAGCCTCCA 1301  TTCAGTACGA CAAAGCATTG ATTGATCGGG AAAACTACTA CAACCACCCC 1351  CTGCCCGACC TCGGCGCGCA CCGCCAAACC GCCCGCTCAT TCGCACTTTC 1401  GGGCAACTGG TATTTCACGC CACAACACAA ACTCAGCCTG ACCGCCTCCC 1451  ATCAGGAACG CCTGCCGTCA ACGCAAGAGC TGTACGCACA CGGCAAACAC 1501  GTCGCCACCA ACACCTTTGA AGTCGGCAAC AAACACCTCA ACAAAGAGCG 1551  TTCCAACAAT ATCGAACTCG CGCTGGGCTA CGAAGGCGAC CGCTGGCAAT 1601  ACAATCTGGC ACTCTACCGC AACCGCTTCG GTAACTACAT TTACGCCCAA 1651  ACCTTAAACG ACGGACGCGG CCCCAAATCC ATCGAAGACG ACAGCGAAAT 1701  GAAGCTCGTG CGCTACAACC AATCCGGCGC CGACTTCTAC GGCGCGGAAG 1751  GCGAAATCTA CTTCAAACCG ACACCGCGCT ACCGCATCGG CGTTTCCGGC 1801  GACTATGTAC GAGGCCGTCT GAAAAACCTG CCTTCCCTAC CCGGCAGAGA 1851  AGATGCCTAC GGCAACCGTC CTTTCATCGC ACAGGACGAC CAAAATGCCC 1901  CCCGTGTTCC GGCTGCGCGC CTCGGCTTCC ACCTGAAAGC CTCGCTGACC 1951  GACCGTATCG ATGCCAATTT GGACTACTAC CGCGTGTTCG CCCAAAACAA 2001  ACTCGCCCGC TACGAAACGC GCACGCCCGG ACACCATATG CTCAACCTCG 2051  GCGCAAACTA CCGCCGCAAT ACGCGCTATG GCGAGTGGAA TTGGTACGTC 2101  AAAGCCGACA ACCTGCTCAA CCAATCCGTT TACGCCCACA GCAGCTTTCT 2151  CTCTGATACG CCGCAAATGG GCCGCAGCTT TACCGGCGGC GTGAACGTGA 2201   AGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 586; ORF 147>:

m147.pep (partial) 1 ..PHKTEQSVDL ETVSVVGKSR PRATSGLLHT STASDKIISGDTLRQKAVNL 51   GDALDGVPGI HASQYGGGAS APVIRGQTGR RIKVLNHHGE TGDMADFSPD101   HAIMVDTALS QQVEILRGPV TLLYSSGNVA GLVDVADGKI PEKMPENGVS 151  GELGLRLSSG NLEKLTSGGI NIGLGKNFVL HTEGLYRKSG DYAVPRYRNL 201  KRLPDSHADS QTGSIGLSWV GEKGFIGVAY SDRRDQYGLP AHSHEYDDCH 251  ADIIWQKSLI NKRYLQLYPH LLTEEDIDYD NPGLSCGFHD DDNAHAHTHS 301  GRPWIDLRNK RYELRAEWKQ PFPGFEALRV HLNRNDYRHD EKAGDAVENF 351  FNNQTQNARI ELRHQPIGRL KGSWGVQYLQ QKSSALSAIS EAVKQPMLLD 401  NKVQHYSFFG VEQANWDNFT LEGGVRVEKQ KASIQYDKAL IDRENYYNHP 451  LPDLGAHRQT ARSFALSGNW YFTPQHKLSL TASHQERLPS TQELYAHGKH 501  VATNTFEVGN KHLNKERSNN IELALGYEGD RWQYNLALYR NRFGNYIYAQ 551  TLNDGRGPKS IEDDSEMKLV RYNQSGADFY GAEGEIYFKP TPRYRIGVSG 601  DYVRGRLKNL PSLPGREDAY GNRPFIAQDD QNAPRVPAAR LGFHLKASLT 651  DRIDANLDYY RVFAQNKLAR YETRTPGHHM LNLGANYRRN TRYGEWNWYV 701  KADNLLNQSV YAHSSFLSDT PQMGRSFTGG VNVKF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m147/g147 92.3% identity in 142 aa overlap                                     10        20        30 m147.pep                             PHKTEQSVDLETVSVVGKSRPRATSGLLHTS                              |:||||| |||||||||||||||||||||| g147MRREAKMAQITLKPIVLSILLINTPLLAQAHETEQSVGLETVSVVGKSRPRATSGLLHTS        10        20        30        40        50        60       40        50        60        70        80        90 m147.pepTASDKIISGDTLRQKAVNLGDALDGVPGIHASQYGGGASAPVIRGQTGRRIKVLNHHGET|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g147TASDKIISGDTLRQKAVNLGDALDGVPGIHASQYGGGASAPVIRGQTGRRIKVLNHHGET        70        80        90       100       110       120      100       110       120       130       140       150 m147.pepGDMADFSPDHAIMVDTALSQQVEILRGPVTLLYSSGNVAGLVDVADGKIPEKMPENGVSG||||||||||||||||||||||||||||||||||||||||  :    | | | g147GDMADFSPDHAIMVDTALSQQVEILRGPVTLLYSSGNVAGAGQCCRWKNPPKNAThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 587>:

a147.seq 1 ATGCGACGAG AAGCCAAAAT GGCACAAACT ACACTCAAAC CCATTGTTTT 51ATCAATTCTT TTAATCAACA CACCCCTCCT CTCCCAAGCG CATGGAACTG 101 AGCAATCAGTGGGCTTGGAA ACGGTCAGCG TCGTCGGCAA AAGCCGTCCG 151 CGCGCCACTT CGGGGCTGCTGCACACTTCT ACCGCCTCCG ACAAAATCAT 201 CAGCGGCGAC ACCTTGCGAC AAAAAGCCGTCAACTTGGGT GATGCTTTAG 251 ACGGCGTACC GGGCATTCAT GCCTCGCAAT ACGGCGGCGGCGCATCCGCT 301 CCCGTTATTC GCGGTCAAAC AGGCAGACGG ATTAAAGTGT TGAACCATCA351 CGGCGAAACG GGCGACATGG CGGACTTCTC TCCAGACCAT GCAATCATGG 401TGGACAGCGC CTTGTCGCAA CAGGTCGAAA TCCTGCGCGG TCCGGTTACG 451 CTCTTGTACAGCTCGGGCAA TGTGGCGGGG CTGGTCGATG TTGCCGATGG 501 CAAAATCCCC GAAAAAATGCCTGAAAACGG CGTATCGGGC GAACTCGGAT 551 TGCGTTTGAG CAGCGGCAAT CTGGAAAAACTCACGTCCGG CGGCATCAAT 601 ATCGGTTTGG GCAAAAACTT TGTATTGCAC ACGGAAGGGCTGTACCGCAA 651 ATCGGGGGAT TACGCCGTAC CGCGTTACCG CAATCTGAAA CGCCTGCCCG701 ACAGCCACGC CGATTCGCAA ACGGGCAGCA TCGGGCTGTC TTGGGTTGGC 751GAAAAAGGCT TTATCGGCGC AGCATACAGC GACCGTCGCG ACCAATATGG 801 TCTGCCTGCCCACAGCCACG AATACGATGA TTGCCACGCC GACATCATCT 851 GGCAAAAGAG TTTGATTAACAAACGCTATT TGCAGCTTTA TCCGCACCTG 901 TTGACCGAAG AAGACATCGA TTACGACAATCCGGGCTTGA GCTGCGGCTT 951 TCACGACGAC GATGATGCAC ACGCCCATGC CCACAACGGCAAACCTTGGA 1001 TAGACCTGCG CAACAAACGC TACGAACTCC GCGCCGAATG GAAGCAACCG1051 TTCCCCGGTT TTGAAGCCCT GCGCGTACAC CTGAACCGCA ACGACTACCG 1101CCACGACGAA AAAGCAGGCG ATGCAGTAGA AAACTTTTTT AACAACCAAA 1151 CGCAAAACGCCCGTATCGAG TTGCGCCACC AACCCATAGG CCGTCTGAAA 1201 GGCAGCTGGG GCGTGCAATATTTGGGACAA AAATCCAGTG CTTTATCTGC 1251 CACATCCGAA GCGGTCAAAC AACCGATGCTGCTTGACAAT AAAGTGCAAC 1301 ATTACAGCTT TTTCGGTGTA GAACAGGCAA ACTGGGACAACTTCACGCTT 1351 GAAGGCGGCG TACGCGTGGA AAAACAAAAA GCCTCCATCC GCTACGACAA1401 AGCATTGATT GATCGGGAAA ACTACTACAA CCATCCCCTG CCCGACCTCG 1451GCGCGCACCG CCAAACCGCC CGCTCATTCG CACTTTCGGG CAACTGGTAT 1501 TTCACGCCACAACACAAACT CAGCCTGACC GCCTCCCATC AGGAACGCCT 1551 GCCGTCAACG CAAGAGCTGTACGCACACGG CAAACACGTC GCCACCAACA 1601 CCTTTGAAGT CGGCAACAAA CACCTCAACAAAGAGCGTTC CAACAATATC 1651 GAACTCGCGC TGGGCTACGA AGGCGACCGC TGGCAATACAATCTGGCACT 1701 CTACCGCAAC CGCTTCGGCA ACTACATTTA CGCCCAAACC TTAAACGACG1751 GACGCGGCCC CAAATCCATC GAAGACGACA GCGAAATGAA GCTCGTGCGC 1801TACAACCAAT CCGGTGCGGA CTTCTACGGC GCGGAAGGCG AAATCTACTT 1851 CAAACCGACACCGCGCTACC GCATCGGCGT TTCCGGCGAC TATGTACGAG 1901 GCCGTCTGAA AAACCTGCCTTCCCTACCCG GCAGGGAAGA CGCCTACGGC 1951 AACCGCCCAC TCATTGCCCA AGCCGACCAAAACGCCCCTC GCGTTCCGGC 2001 TGCGCGCCTC GGCGTCCACC TGAAAGCCTC GCTGACCGACCGCATCGATG 2051 CCAATTTGGA CTACTACCGC GTGTTCGCCC AAAACAAACT CGCCCGCTAC2101 GAAACGCGCA CGCCCGGACA CCATATGCTC AACCTCGGCG CAAACTACCG 2151CCGCAATACG CGCTATGGCG AGTGGAATTG GTACGTCAAA GCCGACAACC 2201 TGCTCAACCAATCCGTTTAC GCCCACAGCA GCTTCCTCTC TGATACGCCG 2251 CAAATGGGCC GCAGCTTTACCGGCGGCGTG AACGTGAAGT TTTAAThis corresponds to the amino acid sequence <SEQ ID 588; ORF 147.a>:

a147.pep 1 MRREAKMAQT TLKPIVLSIL LINTPLLSQA HGTEQSVGLE TVSVVGKSRP 51RATSGLLHTS TASDKIISGD TLRQKAVNLG DALDGVPGIH ASQYGGGASA 101 PVIRGQTGRRIKVLNHHGET GDMADFSPDH AIMVDSALSQ QVEILRGPVT 151 LLYSSGNVAG LVDVADGKIPEKMPENGVSG ELGLRLSSGN LEKLTSGGIN 201 IGLGKNFVLH TEGLYRKSGD YAVPRYRNLKRLPDSHADSQ TGSIGLSWVG 251 EKGFIGAAYS DRRDQYGLPA HSHEYDDCHA DIIWQKSLINKRYLQLYPHL 301 LTEEDIDYDN PGLSCGFHDD DDAHAHAHNG KPWIDLRNKR YELRAEWKQP351 FPGFEALRVH LNRNDYRHDE KAGDAVENFF NNQTQNARIE LRHQPIGRLK 401GSWGVQYLGQ KSSALSATSE AVKQPMLLDN KVQHYSFFGV EQANWDNFTL 451 EGGVRVEKQKASIRYDKALI DRENYYNHPL PDLGAHRQTA RSFALSGNWY 501 FTPQHKLSLT ASHQERLPSTQELYAHGKHV ATNTFEVGNK HLNKERSNNI 551 ELALGYEGDR WQYNLALYRN RFGNYIYAQTLNDGRGPKSI EDDSEMKLVR 601 YNQSGADFYG AEGEIYFKPT PRYRIGVSGD YVRGRLKNLPSLPGREDAYG 651 NRPLIAQADQ NAPRVPAARL GVHLKASLTD RIDANLDYYR VFAQNKLARY701 ETRTPGHHML NLGANYRRNT RYGEWNWYVK ADNLLNQSVY AHSSFLSDTP 751QMGRSFTGGV NVKF* m147/a147 98.1% identity in 734 aa overlap                                     10        20        30 m147.pep                             PHKTEQSVDLETVSVVGKSRPRATSGLLHTS                              | ||||| |||||||||||||||||||||| a147MRREAKMAQTTLKPIVLSILLINTPLLSQAHGTEQSVGLETVSVVGKSRPRATSGLLHTS        10        20        30        40        50        60       40        50        60        70        80        90 m147.pepTASDKIISGDTLRQKAVNLGDALDGVPGIHASQYGGGASAPVIRGQTGRRIKVLNHHGET|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a147TASDKIISGDTLRQKAVNLGDALDGVPGIHASQYGGGASAPVIRGQTGRRIKVLNHHGET        70        80        90       100       110       120      100       110       120       130       140       150 m147.pepGDMADFSPDHAIMVDTALSQQVEILRGPVTLLYSSGNVAGLVDVADGKIPEKMPENGVSG|||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||| a147GDMADFSPDHAIMVDSALSQQVEILRGPVTLLYSSGNVAGLVDVADGKIPEKMPENGVSG       130       140       150       160       170       180      160       170       180       190       200       210 m147.pepELGLRLSSGNLEKLTSGGINIGLGKNFVLHTEGLYRKSGDYAVPRYRNLKRLPDSHADSQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a147ELGLRLSSGNLEKLTSGGINIGLGKNFVLHTEGLYRKSGDYAVPRYRNLKRLPDSHADSQ       190       200       210       220       230       240      220       230       240       250       260       270 m147.pepTGSIGLSWVGEKGFIGVAYSDRRDQYGLPAHSHEYDDCHADIIWQKSLINKRYLQLYPHL||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||| a147TGSIGLSWVGEKGFIGAAYSDRRDQYGLPAHSHEYDDCHADIIWQKSLINKRYLQLYPHL       250       260       270       280       290       300      280       290       300       310       320       330 m147.pepLTEEDIDYDNPGLSCGFHDDDNAHAHTHSGRPWIDLRNKRYELRAEWKQPFPGFEALRVH|||||||||||||||||||||:||||:|:|:||||||||||||||||||||||||||||| a147LTEEDIDYDNPGLSCGFHDDDDAHAHAHNGKPWIDLRNKRYELRAEWKQPFPGFEALRVH       310       320       330       340       350       360      340       350       360       370       380       390 m147.pepLNRNDYRHDEKAGDAVENFFNNQTQNARIELRHQPIGRLKGSWGVQYLQQKSSALSAISE|||||||||||||||||||||||||||||||||||||||||||||||| |||||||| || a147LNRNDYRHDEKAGDAVENFFNNQTQNARIELRHQPIGRLKGSWGVQYLGQKSSALSATSE       370       380       390       400       410       420      400       410       420       430       440       450 m147.pepAVKQPMLLDNKVQHYSFFGVEQANWDNFTLEGGVRVEKQKASIQYDKALIDRENYYNHPL|||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||| a147AVKQPMLLDNKVQHYSFFGVEQANWDNFTLEGGVRVEKQKASIRYDKALIDRENYYNHPL       430       440       450       460       470       480      460       470       480       490       500       510 m147.pepPDLGAHRQTARSFALSGNWYFTPQHKLSLTASHQERLPSTQELYAHGKHVATNTFEVGNK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a147PDLGAHRQTARSFALSGNWYFTPQHKLSLTASHQERLPSTQELYAHGKHVATNTFEVGNK       490       500       510       520       530       540      520       530       540       550       560       570 m147.pepHLNKERSNNIELALGYEGDRWQYNLALYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a147HLNKERSNNIELALGYEGDRWQYNLALYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVR       550       560       570       580       590       600      580       590       600       610       620       630 m147.pepYNQSGADFYGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDAYGNRPFIAQDDQ|||||||||||||||||||||||||||||||||||||||||||||||||||||:||| || a147YNQSGADFYGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDAYGNRPLIAQADQ       610       620       630       640       650       660      640       650       660       670       680       690 m147.pepNAPRVPAARLGFHLKASLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNT||||||||||| |||||||||||||||||||||||||||||||||||||||||||||||| a147NAPRVPAARLGVHLKASLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNT       670       680       690       700       710       720      700       710       720       730 m147.pepRYGEWNWYVKADNLLNQSVYAHSSFLSDTPQMGRSFTGGVNVKFX||||||||||||||||||||||||||||||||||||||||||||| a147RYGEWNWYVKADNLLNQSVYAHSSFLSDTPQMGRSFTGGVNVKFX       730       740       750       760The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 589>:

g148.seq 1 ATGGCGTTAA AAACATCAAA CTTGGAACAC GCAATGctgg ttcaTCCCGA 51AgctATgagt gtcggcgCGC TTGccgAcaa AATCCGCAAA AtcgaAAact 101 gGCCGCAAAAAGgcaTCTTA TTCCACGACA TCACGCCCGT CCTGCAAAGT 151 GCGGAATACT TCCGCCTTTTGGTCGATTTG CTGGTTTACC GCTATATGGA 201 TCAGAAAATC GACATCGTTG CCGGCTTGGACGCGCGCGGC TTCATTATCG 251 GCGCGGCACT CGCCTACCAG CTCAaCGtcg gctTCGTCCCCATCCGCAAA 301 AAAGGCAAGC TGCCTTTTGA AACCGTATCG CAAAGCTAcg cgcTCGAATA351 CGGGGAAGCT GCGGTGGAAA TCCACACCGa tgccgTCAAA CCCGGTTCGC 401GCGTCCTGCT GGTCGATGAT TTGGTTGCCA CGGGCGGCAC AATGCTTGCC 451 GGGCTGGAACTGATCCGCAA ACTCGGCGGG GAAATTGTCG AAgccgccgC 501 CATTTTGGAA TTTACCGACCTTCAAGGCGG CAAGAATATC CGCGCAAGTG 551 GCGCGCCCTT ATTTACCCTG CTTCAAAACGAAGGCTGCAT GAAAGGCTGAThis corresponds to the amino acid sequence <SEQ ID 590; ORF 148.ng>:

g148.pep 1 MALKTSNLEH AMLVHPEAMS VGALADKIRK IENWPQKGIL FHDITPVLQS 51AEYFRLLVDL LVYRYMDQKI DIVAGLDARG FIIGAALAYQ LNVGFVPIRK 101 KGKLPFETVSQSYALEYGEA AVEIHTDAVK PGSRVLLVDD LVATGGTMLA 151 GLELIRKLGG EIVEAAAILEFTDLQGGKNI RASGAPLFTL LQNEGCMKG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 591>:

m148.seq 1 ATGGCGTTAA AAACATCAAA CTTGGAACAC GCAATGCTGG TTCATCCCGA 51AGCTATGAGT GTCGGCGCGC TTGCCGACAA AATCCGCAAA ATCGAAAACT 101 GGCCGCAAAAAGGCATCTTA TTCCACGACA TCACGCCCGT CCTTCAAAGC 151 GCGGAATACT TCCGCCTTTTGGTTGATTTA TTGGTTTACC GCTATATGGA 201 TCAGAAAATC GACATCGTTG CCGGTTTGGACGCGCGCGGC TTCATTATCG 251 GCGCGGCACT CGCCTACCAG CTCAACGTCG GTTTCGTCCCCATCCGCAAA 301 AAAGGCAAGC TGCCTTTTGA AACCGTATCG CAAAGCTACG CGCTCGAATA351 CGGGGAAGCT GCGGTGGAAA TCCACACCGA TGCCGTCAAA CTCGGTTCGC 401GCGTGCTGCT GGTCGATGAT TTGATTGCCA CGGGCGGCAC GATGCTTGCC 451 GGACTGGAACTGATCCGCAA ACTCGGCGGA GAAATTGTCG AAGCCGCCGC 501 CATTTTGGAA TTTACCGACCTTCAAGGCGG CAAGAATATC CGTGCAAGCG 551 GCGCGCCCTT ATTTACCCTG CTTCAAAACGAAGGCTGTAT GAAGGGCTGAThis corresponds to the amino acid sequence <SEQ ID 592; ORF 148>:

m148.pep 1 MALKTSNLEH AMLVHPEAMS VGALADKIRK IENWPQKGIL FHDITPVLQS 51AEYFRLLVDL LVYRYMDQKI DIVAGLDARG FIIGAALAYQ LNVGFVPIRK 101 KGKLPFETVSQSYALEYGEA AVEIHTDAVK LGSRVLLVDD LIATGGTMLA 151 GLELIRKLGG EIVEAAAILEFTDLQGGKNI RASGAPLFTL LQNEGCMKG*Computer analysis of this amino acid sequence gave the followingresults:

m148/g148 99.0% identity in 199 aa overlap        10        20        30        40        50        60 m148.pepMALKTSNLEHAMLVHPEAMSVGALADKIRKIENWPQKGILFHDITPVLQSAEYFRLLVDL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g148MALKTSNLEHAMLVHPEAMSVGALADKIRKIENWPQKGILFHDITPVLQSAEYFRLLVDL        10        20        30        40        50        60        70        80        90       100       110       120 m148.pepLVYRYMDQKIDIVAGLDARGFIIGAALAYQLNVGFVPIRKKGKLPFETVSQSYALEYGEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g148LVYRYMDQKIDIVAGLDARGFIIGAALAYQLNVGFVPIRKKGKLPFETVSQSYALEYGEA        70        80        90       100       110       120       130       140       150       160       170       180 m148.pepAVEIHTDAVKLGSRVLLVDDLIATGGTMLAGLELIRKLGGEIVEAAAILEFTDLQGGKNI|||||||||| ||||||||||:|||||||||||||||||||||||||||||||||||||| g148AVEIHTDAVKPGSRVLLVDDLVATGGTMLAGLELIRKLGGEIVEAAAILEFTDLQGGKNI       130       140       150       160       170       180       190       200 m148.pep RASGAPLFTLLQNEGCMKGX ||||||||||||||||||||g148 RASGAPLFTLLQNEGCMKGX        190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 593>:

a148.seq 1 ATGGCGTTAA AAACATCAAA CTTGGAACAC GCAATGCTGG TTCATCCCGA 51AGCTATGAGT GTCGGTGCGC TTGCCGACAA AATCCGCAAA ATCGAAAACT 101 GGCCGCAAAAAGGCATCTTA TTCCACGACA TCACGCCCGT CCTGCAAAGC 151 GCGGAATACT TCCGACTTTTGGTTGATTTA TTGGTTTACC GCTATATGGA 201 TCAGAAAATC GACATCGTTG CCGGTTTGGACGCGCGCGGC TTCATTATCG 251 GCGCGGCACT CGCCTACCAG CTCAACGTCG GTTTCGTCCCCATCCGCAAA 301 AAAGGCAAGC TGCCTTTTGA AACCGTATCG CAAAGCTACG CGCTCGAATA351 CGGGGAAGCT GCGGTGGAAA TCCACACCGA TGCCGTCAAA CTCGGTTCGC 401GCGTGCTGCT GGTCGATGAT TTGGTTGCCA CGGGCGGCAC GATGCTTGCC 451 GGACTGGAGCTGATCCGCAA ACTCGGCGGG GAAATTGTCG AAGCCGCCGC 501 CATTTTGGAA TTTACCGACCTTCAAGGCGG CAAGAATATC CGTGCAAGCG 551 GCGCGCCCTT ATTTACCCTG CTTCAAAACGAAGGCTGTAT GAAGGGCTGAThis corresponds to the amino acid sequence <SEQ ID 594; ORF 148.a>:

a148.pep 1 MALKTSNLEH AMLVHPEAMS VGALADKIRK IENWPQKGIL FHDITPVLQS 51AEYFRLLVDL LVYRYMDQKI DIVAGLDARG FIIGAALAYQ LNVGFVPIRK 101 KGKLPFETVSQSYALEYGEA AVEIHTDAVK LGSRVLLVDD LVATGGTMLA 151 GLELIRKLGG EIVEAAAILEFTDLQGGKNI RASGAPLFTL LQNEGCMKG* m148/a148 99.5% identity in 199 aaoverlap         10        20        30        40        50        60m148.pep MALKTSNLEHAMLVHPEAMSVGALADKIRKIENWPQKGILFHDITPVLQSAEYFRLLVDL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a148MALKTSNLEHAMLVHPEAMSVGALADKIRKIENWPQKGILFHDITPVLQSAEYFRLLVDL        10        20        30        40        50        60        70        80        90       100       110       120 m148.pepLVYRYMDQKIDIVAGLDARGFIIGAALAYQLNVGFVPIRKKGKLPFETVSQSYALEYGEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a148LVYRYMDQKIDIVAGLDARGFIIGAALAYQLNVGFVPIRKKGKLPFETVSQSYALEYGEA        70        80        90       100       110       120       130       140       150       160       170       180 m148.pepAVEIHTDAVKLGSRVLLVDDLIATGGTMLAGLELIRKLGGEIVEAAAILEFTDLQGGKNI|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| a148AVEIHTDAVKLGSRVLLVDDLVATGGTMLAGLELIRKLGGEIVEAAAILEFTDLQGGKNI       130       140       150       160       170       180       190       200 m148.pep RASGAPLFTLLQNEGCMKGX ||||||||||||||||||||a148 RASGAPLFTLLQNEGCMKGX        190       200The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 595>:

g149.seq 1 ATGTTGATTG ACAACAATGT CCGCCATTAC AGCTTTTTCG GTGTAGAACA 51GGCAAATTGG GACAACTTCA CGCTTGAAGG CGGCGTACGC GTGGAAAAAC 101 AAAAAGCCTCCATCCGGTAC GACAAAGCAT TGATTGATCG AGAAAACTAC 151 TACAACCAGC CCCTGCCCGACCTCGGCGCG CACCGCCAAA CCGCCCGCTC 201 GTTCGCACTT TCGGGCAACT GGTATTTCACGCCACACCAC AAACTCAGCC 251 TGACCGCCTC CCATCAGGAa cgCCTGCCGT CAACGCaagAactGtACgca 301 cacggcAAGC ACGtcgccac CAACACCTTT GAagtcggca acaaACACCT351 CAACAAAGaG CgttccaacA atatcgaACT CGCGCTGGgc tAcaaaggcg 401accGCTGGCA ATACAATCTG GCAGCCTACC GCAACCGAtT CGGCAACTAC 451 ATTTACGCCCAAACCTTAaa cgacggacgC GGCCCCAAAT CCATCgaaga 501 cgacagcgaA ATGaagcTCGTGCGCTACAA CCAATCCGGT GCCGACTTCT 551 ACGgcgcggA aggcgaaatc tACTTcaaaCCGAcACCGCG CTACCGCATC 601 GGTGTTTCCG GCGACTatgt acgaggccgT CTGAAAAACCTGCCGTCCCT 651 ACCCGGCAGG gaagatccCT AcggcAAACG TCccttcaTC GCACAAGCCG701 ACCAAAACGC CCCCCGCATT ccggctGCGC GCCTCGGCTT CCACCTGAAA 751ACCTCGCTAA CCGACCGTAT CGATGCCAAT TTGGACTACT ACCGCGTGTT 801 CGCCCAAAACAAACTCGCCC GCTACGAAAC GCGTACGCCC GGACACCATA 851 TGCTCAACCT CGGTGCAAACTACCGCCGCA ATACGCGCTA TGGCGAGTGG 901 AATTGGTACG TCAAAGCCGA CAACCTGCtcaACcaatCcg tTTACGCCCa 951 cAGCAGCTTC CTCTCTGATA CGCCGCAAAt gGGCCGCAGCTTtgccgGCg 1001 gcgtaAACGT GaAGTTttaAThis corresponds to the amino acid sequence <SEQ ID 596; ORF 149.ng>:

g149.pep 1 MLIDNNVRHY SFFGVEQANW DNFTLEGGVR VEKQKASIRY DKALIDRENY 51YNQPLPDLGA HRQTARSFAL SGNWYFTPHH KLSLTASHQE RLPSTQELYA 101 HGKHVATNTFEVGNKHLNKE RSNNIELALG YKGDRWQYNL AAYRNRFGNY 151 IYAQTLNDGR GPKSIEDDSEMKLVRYNQSG ADFYGAEGEI YFKPTPRYRI 201 GVSGDYVRGR LKNLPSLPGR EDPYGKRPFIAQADQNAPRI PAARLGFHLK 251 TSLTDRIDAN LDYYRVFAQN KLARYETRTP GHHMLNLGANYRRNTRYGEW 301 NWYVKADNLL NQSVYAHSSF LSDTPQMGRS FAGGVNVKF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 597>:

m149.seq 1 ATGCTGCTTG ACAACAAAGT GCAACATTAC AGCTTTTTCG GTGTAGAACA 51GGCAAACTGG GACAACTTCA CGCTTGAAGG AGGCGTACGC GTGGAAAAAC 101 AAAAAGCCTCCATTCAGTAC GACAAAGCAT TGATTGATCG GGAAAACTAC 151 TACAACCACC CCCTGCCCGACCTCGGCGCG CACCGCCAAA CCGCCCGCTC 201 ATTCGCACTT TCGGGCAACT GGTATTTCACGCCACAACAC AAACTCAGCC 251 TGACCGCCTC CCATCAGGAA CGCCTGCCGT CAACGCAAGAGCTGTACGCA 301 CACGGCAAAC ACGTCGCCAC CAACACCTTT GAAGTCGGCA ACAAACACCT351 CAACAAAGAG CGTTCCAACA ATATCGAACT CGCGCTGGGC TACGAAGGCG 401ACCGCTGGCA ATACAATCTG GCACTCTACC GCAACCGCTT CGGTAACTAC 451 ATTTACGCCCAAACCTTAAA CGACGGACGC GGCCCCAAAT CCATCGAAGA 501 CGACAGCGAA ATGAAGCTCGTGCGCTACAA CCAATCCGGC GCCGACTTCT 551 ACGGCGCGGA AGGCGAAATC TACTTCAAACCGACACCGCG CTACCGCATC 601 GGCGTTTCCG GCGACTATGT ACGAGGCCGT CTGAAAAACCTGCCTTCCCT 651 ACCCGGCAGA GAAGATGCCT ACGGCAACCG TCCTTTCATC GCACAGGACG701 ACCAAAATGC CCCCCGTGTT CCGGCTGCGC GCCTCGGCTT CCACCTGAAA 751GCCTCGCTGA CCGACCGTAT CGATGCCAAT TTGGACTACT ACCGCGTGTT 801 CGCCCAAAACAAACTCGCCC GCTACGAAAC GCGCACGCCC GGACACCATA 851 TGCTCAACCT CGGCGCAAACTACCGCCGCA ATACGCGCTA TGGCGAGTGG 901 AATTGGTACG TCAAAGCCGA CAACCTGCTCAACCAATCCG TTTACGCCCA 951 CAGCAGCTTT CTCTCTGATA CGCCGCAAAT GGGCCGCAGCTTTACCGGCG 1001 GCGTGAACGT GAAGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 598; ORF 149>:

m149.pep 1 MLLDNKVQHY SFFGVEQANW DNFTLEGGVR VEKQKASIQY DKALIDRENY 51YNHPLPDLGA HRQTARSFAL SGNWYFTPQH KLSLTASHQE RLPSTQELYA 101 HGKHVATNTFEVGNKHLNKE RSNNIELALG YEGDRWQYNL ALYRNRFGNY 151 IYAQTLNDGR GPKSIEDDSEMKLVRYNQSG ADFYGAEGEI YFKPTPRYRI 201 GVSGDYVRGR LKNLPSLPGR EDAYGNRPFIAQDDQNAPRV PAARLGFHLK 251 ASLTDRIDAN LDYYRVFAQN KLARYETRTP GHHMLNLGANYRRNTRYGEW 301 NWYVKADNLL NQSVYAHSSF LSDTPQMGRS FTGGVNVKF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 149 shows 95.9% identity over a 339 aa overlap with a predicted ORF(ORF 149.ng) from N. gonorrhoeae:

m149/g149         10        20        30        40        50        60m149.pep MLLDNKVQHYSFFGVEQANWDNFTLEGGVRVEKQKASIQYDKALIDRENYYNHPLPDLGA||:||:|:||||||||||||||||||||||||||||||:|||||||||||||:||||||| g149MLIDNNVRHYSFFGVEQANWDNFTLEGGVRVEKQKASIRYDKALIDRENYYNQPLPDLGA        10        20        30        40        50        60        70        80        90       100       110       120 m149.pepHRQTARSFALSGNWYFTPQHKLSLTASHQERLPSTQELYAHGKHVATNTFEVGNKHLNKE||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||| g149HRQTARSFALSGNWYFTPHHKLSLTASHQERLPSTQELYAHGKHVATNTFEVGNKHLNKE        70        80        90       100       110       120       130       140       150       160       170       180 m149.pepRSNNIELALGYEGDRWQYNLALYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVRYNQSG|||||||||||:||||||||| |||||||||||||||||||||||||||||||||||||| g149RSNNIELALGYKGDRWQYNLAAYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVRYNQSG       130       140       150       160       170       180       190       200       210       220       230       240 m149.pepADFYGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDAYGNRPFIAQDDQNAPRV|||||||||||||||||||||||||||||||||||||||||| ||:|||||| ||||||: g149ADFYGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDPYGKRPFIAQADQNAPRI       190       200       210       220       230       240       250       260       270       280       290       300 m149.pepPAARLGFHLKASLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNTRYGEW||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||| g149PAARLGFHLKTSLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNTRYGEW       250       260       270       280       290       300       310       320       330       340 m149.pepNWYVKADNLLNQSVYAHSSFLSDTPQMGRSFTGGVNVKFX|||||||||||||||||||||||||||||||:|||||||| g149NWYVKADNLLNQSVYAHSSFLSDTPQMGRSFAGGVNVKFX       310       320       330       340The following partial DNA sequence was identified in N. meningitidis<SEQ ID 599>:

a149.seq 1 ATGCTGCTTG ACAATAAAGT GCAACATTAC AGCTTTTTCG GTGTAGAACA 51GGCAAACTGG GACAACTTCA CGCTTGAAGG CGGCGTACGC GTGGAAAAAC 101 AAAAAGCCTCCATCCGCTAC GACAAAGCAT TGATTGATCG GGAAAACTAC 151 TACAACCATC CCCTGCCCGACCTCGGCGCG CACCGCCAAA CCGCCCGCTC 201 ATTCGCACTT TCGGGCAACT GGTATTTCACGCCACAACAC AAACTCAGCC 251 TGACCGCCTC CCATCAGGAA CGCCTGCCGT CAACGCAAGAGCTGTACGCA 301 CACGGCAAAC ACGTCGCCAC CAACACCTTT GAAGTCGGCA ACAAACACCT351 CAACAAAGAG CGTTCCAACA ATATCGAACT CGCGCTGGGC TACGAAGGCG 401ACCGCTGGCA ATACAATCTG GCACTCTACC GCAACCGCTT CGGCAACTAC 451 ATTTACGCCCAAACCTTAAA CGACGGACGC GGCCCCAAAT CCATCGAAGA 501 CGACAGCGAA ATGAAGCTCGTGCGCTACAA CCAATCCGGT GCGGACTTCT 551 ACGGCGCGGA AGGCGAAATC TACTTCAAACCGACACCGCG CTACCGCATC 601 GGCGTTTCCG GCGACTATGT ACGAGGCCGT CTGAAAAACCTGCCTTCCCT 651 ACCCGGCAGG GAAGACGCCT ACGGCAACCG CCCACTCATT GCCCAAGCCG701 ACCAAAACGC CCCTCGCGTT CCGGCTGCGC GCCTCGGCGT CCACCTGAAA 751GCCTCGCTGA CCGACCGCAT CGATGCCAAT TTGGACTACT ACCGCGTGTT 801 CGCCCAAAACAAACTCGCCC GCTACGAAAC GCGCACGCCC GGACACCATA 851 TGCTCAACCT CGGCGCAAACTACCGCCGCA ATACGCGCTA TGGCGAGTGG 901 AATTGGTACG TCAAAGCCGA CAACCTGCTCAACCAATCCG TTTACGCCCA 951 CAGCAGCTTC CTCTCTGATA CGCCGCAAAT GGGCCGCAGCTTTACCGGCG 1001 GCGTGAACGT GAAGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 600; ORF 149.a>:

a149.pep 1 MLLDNKVQHY SFFGVEQANW DNFTLEGGVR VEKQKASIRY DKALIDRENY 51YNHPLPDLGA HRQTARSFAL SGNWYFTPQH KLSLTASHQE RLPSTQELYA 101 HGKHVATNTFEVGNKHLNKE RSNNIELALG YEGDRWQYNL ALYRNRFGNY 151 IYAQTLNDGR GPKSIEDDSEMKLVRYNQSG ADFYGAEGEI YFKPTPRYRI 201 GVSGDYVRGR LKNLPSLPGR EDAYGNRPLIAQADQNAPRV PAARLGVHLK 251 ASLTDRIDAN LDYYRVFAQN KLARYETRTP GHHMLNLGANYRRNTRYGEW 301 NWYVKADNLL NQSVYAHSSF LSDTPQMGRS FTGGVNVKF* m149/a14998.8% identity in 339 aa overlap        10        20        30        40        50        60 m149.pepMLLDNKVQHYSFFGVEQANWDNFTLEGGVRVEKQKASIQYDKALIDRENYYNHPLPDLGA||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||| a149MLLDNKVQHYSFFGVEQANWDNFTLEGGVRVEKQKASIRYDKALIDRENYYNHPLPDLGA        10        20        30        40        50        60        70        80        90       100       110       120 m149.pepHRQTARSFALSGNWYFTPQHKLSLTASHQERLPSTQELYAHGKHVATNTFEVGNKHLNKE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a149HRQTARSFALSGNWYFTPQHKLSLTASHQERLPSTQELYAHGKHVATNTFEVGNKHLNKE        70        80        90       100       110       120       130       140       150       160       170       180 m149.pepRSNNIELALGYEGDRWQYNLALYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVRYNQSG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a149RSNNIELALGYEGDRWQYNLALYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVRYNQSG       130       140       150       160       170       180       190       200       210       220       230       240 m149.pepADFYGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDAYGNRPFIAQDDQNAPRV||||||||||||||||||||||||||||||||||||||||||||||||:||| ||||||| a149ADFYGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDAYGNRPLIAQADQNAPRV       190       200       210       220       230       240       250       260       270       280       290       300 m149.pepPAARLGFHLKASLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNTRYGEW|||||| ||||||||||||||||||||||||||||||||||||||||||||||||||||| a149PAARLGVHLKASLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNTRYGEW       250       260       270       280       290       300       310       320       330       340 m149.pepNWYVKADNLLNQSVYAHSSFLSDTPQMGRSFTGGVNVKFX|||||||||||||||||||||||||||||||||||||||| a149NWYVKADNLLNQSVYAHSSFLSDTPQMGRSFTGGVNVKFX       310       320       330       340The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 601>:

g149-1.seq 1 ATGGCACAAA TCACACTCAA ACCCATTGTT TTATCAATTC TTTTAATCAA 51CACACCCCTC CTCGCCCAAG CGCATGAAAC TGAGCAATCG GTGGGCTTGG 101 AAACGGTCAGCGTCGTCGGC AAAAGCCGTC CGCGCGCGAC TTCGGGGCTG 151 CTGCACACTT CGACCGCCTCCGACAAAATC ATCTCCGGCG ATACTTTGCG 201 CCAAAAAGCC GTCAACTTGG GCGACGCTTTGGACGGCGTA CCGGGCATCC 251 ACGCTTCGCA ATACGGCGGC GGCGCATCCG CTCCCGTTATTCGCGGTCAA 301 ACGGGCAGAC GGATTAAAGT ATTGAACCAT CACGGCGAAA CGGGCGATAT351 GGCGGACTTT TCTCCCGATC ACGCCATTAT GGTAGATACC GCCTTGTCGC 401AACAGGTTGA AATCCTGCGC GGGCCGGTTA CGCTCTTGTA CAGCTCGGGC 451 AATGTGGCGGGGCTGGTCGA TGTTGCCGAT GGAAAAATCC CCGAAAAAAT 501 GCCTGAAAAC GGCGTATCGGGCGaagccgG ATTGCGTTTG AGCAGCGGCA 551 ATTTAGAAAA ACTGACATCC GCAGGCATCAATATCGGACT GGGCAAAAAC 601 TTCGTGCTGC ATACCGAAGG CTTGTACCGC AAATCGGGCGATTACGCCGT 651 ACCGCGTTAC CGCAATCTGA AACGCCTGCC CGACAGCCAT GCCGATTCGC701 AAACGGGCAG CATCGGGCTG TCTTGGGTGG GCGAAAAAGG CTTTATCGGC 751GCAGCATACA GCGACCGTCG CGACCGCTAC GGCCTGCCTG CCCACAGCCA 801 CGAATACGATGATTGCCACG CCGACATCAT CTGGCAAAAG AGTTTGATCA 851 ACAAACGCTA TTTGCAGCTTTATCCGCACT TGTTGACCGA AGAAGACATC 901 GATTACGACA ATCCGGGCTT GAGCTGCGGCTTCCACGACG GCGACGGTGC 951 ACACGCACAC ACCCACAACG GCAAACCGTG GATAGACCTGCGCAACAAAC 1001 GCTACGAACT CCGCGCCGAA TGGAAGCAGC CATTCCCCGG TTTTGAAGCC1051 CTGCGCGTAC ATCTGAACCG CAATGACTAC CACCACGACG AAAAAGCAGG 1101CGATGCAGTA GAAAACTTCT TCAACAACAA AACACACAAC GCCCGTATCG 1151 AGTTGCGCCACCAACCCATA GGCCGTCTGA AAGGCAGCTG GGGCGTGCAA 1201 TATTTGGGAC AAAAATCCAGCGCGCTTTCC GCCATTCCCG AAACCGTCCA 1251 ACAACCGATG TTGATTGACA ACAATGTCCGCCATTACAGC TTTTTCGGTG 1301 TAGAACAGGC AAATTGGGAC AACTTCACGC TTGAAGGCGGCGTACGCGTG 1351 GAAAAACAAA AAGCCTCCAT CCGGTACGAC AAAGCATTGA TTGATCGAGA1401 AAACTACTAC AACCAGCCCC TGCCCGACCT CGGCGCGCAC CGCCAAACCG 1451CCCGCTCGTT CGCACTTTCG GGCAACTGGT ATTTCACGCC ACACCACAAA 1501 CTCAGCCTGACCGCCTCCCA TCAGGAACGC CTGCCGTCAA CGCAAGAACT 1551 GTACGCACAC GGCAAGCACGTCGCCACCAA CACCTTTGAA GTCGGCAACA 1601 AACACCTCAA CAAAGAGCGT TCCAACAATATCGAACTCGC GCTGGGCTAC 1651 GAAGGCGACC GCTGGCAATA CAATCTGGCA GCCTACCGCAACCGATTCGG 1701 CAACTACATT TACGCCCAAA CCTTAAACGA CGGACGCGGC CCCAAATCCA1751 TCGAAGACGA CAGCGAAATG AAGCTCGTGC GCTACAACCA ATCCGGTGCC 1801GACTTCTACG GCGCGGAAGG CGAAATCTAC TTCAAACCGA CACCGCGCTA 1851 CCGCATCGGTGTTTCCGGCG ACTATGTACG AGGCCGTCTG AAAAACCTGC 1901 CGTCCCTACC CGGCAGGGAAGATCCCTACG GCAAACGTCC CTTCATCGCA 1951 CAAGCCGACC AAAACGCCCC CCGCATTCCGGCTGCGCGCC TCGGCTTCCA 2001 CCTGAAAACC TCGCTAACCG ACCGTATCGA TGCCAATTTGGACTACTACC 2051 GCGTGTTCGC CCAAAACAAA CTCGCCCGCT ACGAAACGCG TACGCCCGGA2101 CACCATATGC TCAACCTCGG TGCAAACTAC CGCCGCAATA CGCGCTATGG 2151CGAGTGGAAT TGGTACGTCA AAGCCGACAA CCTGCTCAAC CAATCCGTTT 2201 ACGCCCACAGCAGCTTCCTC TCTGATACGC CGCAAATGGG CCGCAGCTTT 2251 ACCGGCGGCG TAAACGTGAAGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 602; ORF 149-1.ng>:

g149-1.pep 1 MAQITLKPIV LSILLINTPL LAQAHETEQS VGLETVSVVG KSRPRATSGL 51LHTSTASDKI ISGDTLRQKA VNLGDALDGV PGIHASQYGG GASAPVIRGQ 101 TGRRIKVLNHHGETGDMADF SPDHAIMVDT ALSQQVEILR GPVTLLYSSG 151 NVAGLVDVAD GKIPEKMPENGVSGEAGLRL SSGNLEKLTS AGINIGLGKN 201 FVLHTEGLYR KSGDYAVPRY RNLKRLPDSHADSQTGSIGL SWVGEKGFIG 251 AAYSDRRDRY GLPAHSHEYD DCHADIIWQK SLINKRYLQLYPHLLTEEDI 301 DYDNPGLSCG FHDGDGAHAH THNGKPWIDL RNKRYELRAE WKQPFPGFEA351 LRVHLNRNDY HHDEKAGDAV ENFFNNKTHN ARIELRHQPI GRLKGSWGVQ 401YLGQKSSALS AIPETVQQPM LIDNNVRHYS FFGVEQANWD NFTLEGGVRV 451 EKQKASIRYDKALIDRENYY NQPLPDLGAH RQTARSFALS GNWYFTPHHK 501 LSLTASHQER LPSTQELYAHGKHVATNTFE VGNKHLNKER SNNIELALGY 551 EGDRWQYNLA AYRNRFGNYI YAQTLNDGRGPKSIEDDSEM KLVRYNQSGA 601 DFYGAEGEIY FKPTPRYRIG VSGDYVRGRL KNLPSLPGREDPYGKRPFIA 651 QADQNAPRIP AARLGFHLKT SLTDRIDANL DYYRVFAQNK LARYETRTPG701 HHMLNLGANY RRNTRYGEWN WYVKADNLLN QSVYAHSSFL SDTPQMGRSF 751 TGGVNVKF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 603>:

m149-1.seq 1 ATGGCACAAA CTACACTCAA ACCCATTGTT TTATCAATTC TTTTAATCAA 51CACACCCCTC CTCGCCCAAG CGCATGAAAC TGAGCAATCG GTGGATTTGG 101 AAACGGTCAGCGTCGTCGGC AAAAGCCGTC CGCGCGCCAC GTCGGGGCTG 151 TTGCACACTT CGACCGCCTCCGACAAAATC ATCTCCGGCG ATACCTTGCG 201 CCAAAAAGCC GTCAACTTGG GCGACGCTTTAGACGGCGTA CCGGGCATCC 251 ACGCTTCGCA ATACGGCGGC GGCGCGTCTG CTCCCGTCATTCGCGGTCAA 301 ACAGGCAGGC GGATTAAAGT GTTGAACCAT CACGGCGAAA CAGGCGATAT351 GGCGGATTTT TCGCCCGATC ACGCCATTAT GGTAGATACC GCCTTGTCGC 401AACAGGTCGA AATCCTGCGC GGGCCGGTTA CGCTCTTGTA CAGCTCGGGC 451 AATGTGGCGGGGCTGGTCGA TGTTGCCGAT GGCAAAATCC CCGAAAAAAT 501 GCCTGAAAAC GGCGTATCGGGCGAACTCGG ATTGCGTTTG AGCAGCGGCA 551 ATCTGGAAAA ACTCACGTCC GGCGGCATCAATATCGGTTT GGGCAAAAAC 601 TTTGTATTGC ACACGGAAGG GCTGTACCGC AAATCGGGGGATTACGCCGT 651 ACCGCGTTAC CGCAATCTGA AACGCCTGCC CGACAGCCAC GCCGATTCGC701 AAACGGGCAG CATCGGGCTG TCTTGGGTTG GCGAAAAAGG TTTTATCGGC 751GTAGCGTACA GCGACCGTCG CGACCAATAT GGTCTGCCTG CCCACAGCCA 801 CGAATACGATGATTGCCACG CCGACATCAT CTGGCAAAAG AGCTTGATTA 851 ACAAACGCTA TTTACAGCTTTATCCGCACC TGTTGACCGA AGAAGACATC 901 GATTACGACA ATCCGGGCTT GAGCTGCGGCTTCCACGACG ACGATAATGC 951 ACACGCACAC ACCCACAGCG GCAGACCGTG GATAGACCTGCGCAACAAAC 1001 GCTACGAACT CCGTGCCGAA TGGAAGCAAC CGTTCCCCGG TTTTGAAGCC1051 CTGCGCGTAC ACCTGAACCG CAACGACTAC CGCCACGACG AAAAAGCAGG 1101CGATGCAGTC GAAAACTTTT TTAACAACCA AACGCAAAAC GCCCGCATCG 1151 AGTTGCGCCACCAACCCATA GGTCGTCTGA AAGGCAGCTG GGGCGTGCAA 1201 TATTTACAAC AAAAATCCAGTGCTTTATCT GCCATATCCG AAGCGGTTAA 1251 ACAACCGATG CTGCTTGACA ACAAAGTGCAACATTACAGC TTTTTCGGTG 1301 TAGAACAGGC AAACTGGGAC AACTTCACGC TTGAAGGAGGCGTACGCGTG 1351 GAAAAACAAA AAGCCTCCAT TCAGTACGAC AAAGCATTGA TTGATCGGGA1401 AAACTACTAC AACCACCCCC TGCCCGACCT CGGCGCGCAC CGCCAAACCG 1451CCCGCTCATT CGCACTTTCG GGCAACTGGT ATTTCACGCC ACAACACAAA 1501 CTCAGCCTGACCGCCTCCCA TCAGGAACGC CTGCCGTCAA CGCAAGAGCT 1551 GTACGCACAC GGCAAACACGTCGCCACCAA CACCTTTGAA GTCGGCAACA 1601 AACACCTCAA CAAAGAGCGT TCCAACAATATCGAACTCGC GCTGGGCTAC 1651 GAAGGCGACC GCTGGCAATA CAATCTGGCA CTCTACCGCAACCGCTTCGG 1701 TAACTACATT TACGCCCAAA CCTTAAACGA CGGACGCGGC CCCAAATCCA1751 TCGAAGACGA CAGCGAAATG AAGCTCGTGC GCTACAACCA ATCCGGCGCC 1801GACTTCTACG GCGCGGAAGG CGAAATCTAC TTCAAACCGA CACCGCGCTA 1851 CCGCATCGGCGTTTCCGGCG ACTATGTACG AGGCCGTCTG AAAAACCTGC 1901 CTTCCCTACC CGGCAGAGAAGATGCCTACG GCAACCGTCC TTTCATCGCA 1951 CAGGACGACC AAAATGCCCC CCGTGTTCCGGCTGCGCGCC TCGGCTTCCA 2001 CCTGAAAGCC TCGCTGACCG ACCGTATCGA TGCCAATTTGGACTACTACC 2051 GCGTGTTCGC CCAAAACAAA CTCGCCCGCT ACGAAACGCG CACGCCCGGA2101 CACCATATGC TCAACCTCGG CGCAAACTAC CGCCGCAATA CGCGCTATGG 2151CGAGTGGAAT TGGTACGTCA AAGCCGACAA CCTGCTCAAC CAATCCGTTT 2201 ACGCCCACAGCAGCTTTCTC TCTGATACGC CGCAAATGGG CCGCAGCTTT 2251 ACCGGCGGCG TGAACGTGAAGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 604; ORF 149-1>:

m149-1.pep 1 MAQTTLKPIV LSILLINTPL LAQAHETEQS VDLETVSVVG KSRPRATSGL 51LHTSTASDKI ISGDTLRQKA VNLGDALDGV PGIHASQYGG GASAPVIRGQ 101 TGRRIKVLNHHGETGDMADF SPDHAIMVDT ALSQQVEILR GPVTLLYSSG 151 NVAGLVDVAD GKIPEKMPENGVSGELGLRL SSGNLEKLTS GGINIGLGKN 201 FVLHTEGLYR KSGDYAVPRY RNLKRLPDSHADSQTGSIGL SWVGEKGFIG 251 VAYSDRRDQY GLPAHSHEYD DCHADIIWQK SLINKRYLQLYPHLLTEEDI 301 DYDNPGLSCG FHDDDNAHAH THSGRPWIDL RNKRYELRAE WKQPFPGFEA351 LRVHLNRNDY RHDEKAGDAV ENFFNNQTQN ARIELRHQPI GRLKGSWGVQ 401YLQQKSSALS AISEAVKQPM LLDNKVQHYS FFGVEQANWD NFTLEGGVRV 451 EKQKASIQYDKALIDRENYY NHPLPDLGAH RQTARSFALS GNWYFTPQHK 501 LSLTASHQER LPSTQELYAHGKHVATNTFE VGNKHLNKER SNNIELALGY 551 EGDRWQYNLA LYRNRFGNYI YAQTLNDGRGPKSIEDDSEM KLVRYNQSGA 601 DFYGAEGEIY FKPTPRYRIG VSGDYVRGRL KNLPSLPGREDAYGNRPFIA 651 QDDQNAPRVP AARLGFHLKA SLTDRIDANL DYYRVFAQNK LARYETRTPG701 HHMLNLGANY RRNTRYGEWN WYVKADNLLN QSVYAHSSFL SDTPQMGRSF 751 TGGVNVKF*m149-1/g149-1 96.2% identity in 758 aa overlap        10        20        30        40        50        60 m149-1.pepMAQTTLKPIVLSILLINTPLLAQAHETEQSVDLETVSVVGKSRPRATSGLLHTSTASDKI||| ||||||||||||||||||||||||||| |||||||||||||||||||||||||||| g149-1MAQITLKPIVLSILLINTPLLAQAHETEQSVGLETVSVVGKSRPRATSGLLHTSTASDKI        10        20        30        40        50        60        70        80        90       100       110       120 m149-1.pepISGDTLRQKAVNLGDALDGVPGIHASQYGGGASAPVIRGQTGRRIKVLNHHGETGDMADF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g149-1ISGDTLRQKAVNLGDALDGVPGIHASQYGGGASAPVIRGQTGRRIKVLNHHGETGDMADF        70        80        90       100       110       120       130       140       150       160       170       180 m149-1.pepSPDHAIMVDTALSQQVEILRGPVTLLYSSGNVAGLVDVADGKIPEKMPENGVSGELGLRL||||||||||||||||||||||||||||||||||||||||||||||||||||||| |||| g149-1SPDHAIMVDTALSQQVEILRGPVTLLYSSGNVAGLVDVADGKIPEKMPENGVSGEAGLRL       130       140       150       160       170       180       190       200       210       220       230       240 m149-1.pepSSGNLEKLTSGGINIGLGKNFVLHTEGLYRKSGDYAVPRYRNLKRLPDSHADSQTGSIGL||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||| g149-1SSGNLEKLTSAGINIGLGKNFVLHTEGLYRKSGDYAVPRYRNLKRLPDSHADSQTGSIGL       190       200       210       220       230       240       250       260       270       280       290       300 m149-1.pepSWVGEKGFIGVAYSDRRDQYGLPAHSHEYDDCHADIIWQKSLINKRYLQLYPHLLTEEDI||||||||||:|||||||:||||||||||||||||||||||||||||||||||||||||| g149-1SWVGEKGFIGAAYSDRRDRYGLPAHSHEYDDCHADIIWQKSLINKRYLQLYPHLLTEEDI       250       260       270       280       290       300       310       320       330       340       350       360 m149-1.pepDYDNPGLSCGFHDDDNAHAHTHSGRPWIDLRNKRYELRAEWKQPFPGFEALRVHLNRNDY||||||||||||| |:||||||:|:||||||||||||||||||||||||||||||||||| g149-1DYDNPGLSCGFHDGDGAHAHTHNGKPWIDLRNKRYELRAEWKQPFPGFEALRVHLNRNDY       310       320       330       340       350       360       370       380       390       400       410       420 m149-1.pepRHDEKAGDAVENFFNNQTQNARIELRHQPIGRLKGSWGVQYLQQKSSALSAISEAVKQPM:|||||||||||||||:|:||||||||||||||||||||||| ||||||||| |:|:||| g149-1HHDEKAGDAVENFFNNKTHNARIELRHQPIGRLKGSWGVQYLGQKSSALSAIPETVQQPM       370       380       390       400       410       420       430       440       450       460       470       480 m149-1.pepLLDNKVQHYSFFGVEQANWDNFTLEGGVRVEKQKASIQYDKALIDRENYYNHPLPDLGAH|:||:|:||||||||||||||||||||||||||||||:|||||||||||||:|||||||| g149-1LIDNNVRHYSFFGVEQANWDNFTLEGGVRVEKQKASIRYDKALIDRENYYNQPLPDLGAH       430       440       450       460       470       480       490       500       510       520       530       540 m149-1.pepRQTARSFALSGNWYFTPQHKLSLTASHQERLPSTQELYAHGKHVATNTFEVGNKHLNKER|||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||| g149-1RQTARSFALSGNWYFTPHHKLSLTASHQERLPSTQELYAHGKHVATNTFEVGNKHLNKER       490       500       510       520       530       540       550       560       570       580       590       600 m149-1.pepSNNIELALGYEGDRWQYNLALYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVRYNQSGA|||||||||||||||||||| ||||||||||||||||||||||||||||||||||||||| g149-1SNNIELALGYEGDRWQYNLAAYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVRYNQSGA       550       560       570       580       590       600       610       620       630       640       650       660 m149-1.pepDFYGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDAYGNRPFIAQDDQNAPRVP||||||||||||||||||||||||||||||||||||||||| ||:|||||| ||||||:| g149-1DFYGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDPYGKRPFIAQADQNAPRIP       610       620       630       640       650       660       670       680       690       700       710       720 m149-1.pepAARLGFHLKASLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNTRYGEWN|||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||| g149-1AARLGFHLKTSLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNTRYGEWN       670       680       690       700       710       720       730       740       750      759 m149-1.pepWYVKADNLLNQSVYAHSSFLSDTPQMGRSFTGGVNVKFX||||||||||||||||||||||||||||||||||||||| g149-1WYVKADNLLNQSVYAHSSFLSDTPQMGRSFTGGVNVKFX        730       740       750The following partial DNA sequence was identified in N. meningitidis<SEQ ID 605>:

a149-1.seq 1 ATGGCACAAA CTACACTCAA ACCCATTGTT TTATCAATTC TTTTAATCAA 51CACACCCCTC CTCTCCCAAG CGCATGGAAC TGAGCAATCA GTGGGCTTGG 101 AAACGGTCAGCGTCGTCGGC AAAAGCCGTC CGCGCGCCAC TTCGGGGCTG 151 CTGCACACTT CTACCGCCTCCGACAAAATC ATCAGCGGCG ACACCTTGCG 201 ACAAAAAGCC GTCAACTTGG GTGATGCTTTAGACGGCGTA CCGGGCATTC 251 ATGCCTCGCA ATACGGCGGC GGCGCATCCG CTCCCGTTATTCGCGGTCAA 301 ACAGGCAGAC GGATTAAAGT GTTGAACCAT CACGGCGAAA CGGGCGACAT351 GGCGGACTTC TCTCCAGACC ATGCAATCAT GGTGGACAGC GCCTTGTCGC 401AACAGGTCGA AATCCTGCGC GGTCCGGTTA CGCTCTTGTA CAGCTCGGGC 451 AATGTGGCGGGGCTGGTCGA TGTTGCCGAT GGCAAAATCC CCGAAAAAAT 501 GCCTGAAAAC GGCGTATCGGGCGAACTCGG ATTGCGTTTG AGCAGCGGCA 551 ATCTGGAAAA ACTCACGTCC GGCGGCATCAATATCGGTTT GGGCAAAAAC 601 TTTGTATTGC ACACGGAAGG GCTGTACCGC AAATCGGGGGATTACGCCGT 651 ACCGCGTTAC CGCAATCTGA AACGCCTGCC CGACAGCCAC GCCGATTCGC701 AAACGGGCAG CATCGGGCTG TCTTGGGTTG GCGAAAAAGG CTTTATCGGC 751GCAGCATACA GCGACCGTCG CGACCAATAT GGTCTGCCTG CCCACAGCCA 801 CGAATACGATGATTGCCACG CCGACATCAT CTGGCAAAAG AGTTTGATTA 851 ACAAACGCTA TTTGCAGCTTTATCCGCACC TGTTGACCGA AGAAGACATC 901 GATTACGACA ATCCGGGCTT GAGCTGCGGCTTTCACGACG ACGATGATGC 951 ACACGCCCAT GCCCACAACG GCAAACCTTG GATAGACCTGCGCAACAAAC 1001 GCTACGAACT CCGCGCCGAA TGGAAGCAAC CGTTCCCCGG TTTTGAAGCC1051 CTGCGCGTAC ACCTGAACCG CAACGACTAC CGCCACGACG AAAAAGCAGG 1101CGATGCAGTA GAAAACTTTT TTAACAACCA AACGCAAAAC GCCCGTATCG 1151 AGTTGCGCCACCAACCCATA GGCCGTCTGA AAGGCAGCTG GGGCGTGCAA 1201 TATTTGGGAC AAAAATCCAGTGCTTTATCT GCCACATCCG AAGCGGTCAA 1251 ACAACCGATG CTGCTTGACA ATAAAGTGCAACATTACAGC TTTTTCGGTG 1301 TAGAACAGGC AAACTGGGAC AACTTCACGC TTGAAGGCGGCGTACGCGTG 1351 GAAAAACAAA AAGCCTCCAT CCGCTACGAC AAAGCATTGA TTGATCGGGA1401 AAACTACTAC AACCATCCCC TGCCCGACCT CGGCGCGCAC CGCCAAACCG 1451CCCGCTCATT CGCACTTTCG GGCAACTGGT ATTTCACGCC ACAACACAAA 1501 CTCAGCCTGACCGCCTCCCA TCAGGAACGC CTGCCGTCAA CGCAAGAGCT 1551 GTACGCACAC GGCAAACACGTCGCCACCAA CACCTTTGAA GTCGGCAACA 1601 AACACCTCAA CAAAGAGCGT TCCAACAATATCGAACTCGC GCTGGGCTAC 1651 GAAGGCGACC GCTGGCAATA CAATCTGGCA CTCTACCGCAACCGCTTCGG 1701 CAACTACATT TACGCCCAAA CCTTAAACGA CGGACGCGGC CCCAAATCCA1751 TCGAAGACGA CAGCGAAATG AAGCTCGTGC GCTACAACCA ATCCGGTGCG 1801GACTTCTACG GCGCGGAAGG CGAAATCTAC TTCAAACCGA CACCGCGCTA 1851 CCGCATCGGCGTTTCCGGCG ACTATGTACG AGGCCGTCTG AAAAACCTGC 1901 CTTCCCTACC CGGCAGGGAAGACGCCTACG GCAACCGCCC ACTCATTGCC 1951 CAAGCCGACC AAAACGCCCC TCGCGTTCCGGCTGCGCGCC TCGGCGTCCA 2001 CCTGAAAGCC TCGCTGACCG ACCGCATCGA TGCCAATTTGGACTACTACC 2051 GCGTGTTCGC CCAAAACAAA CTCGCCCGCT ACGAAACGCG CACGCCCGGA2101 CACCATATGC TCAACCTCGG CGCAAACTAC CGCCGCAATA CGCGCTATGG 2151CGAGTGGAAT TGGTACGTCA AAGCCGACAA CCTGCTCAAC CAATCCGTTT 2201 ACGCCCACAGCAGCTTCCTC TCTGATACGC CGCAAATGGG CCGCAGCTTT 2251 ACCGGCGGCG TGAACGTGAAGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 606; ORF 149-1.a>:

a149-1.pep 1 MAQTTLKPIV LSILLINTPL LSQAHGTEQS VGLETVSVVG KSRPRATSGL 51LHTSTASDKI ISGDTLRQKA VNLGDALDGV PGIHASQYGG GASAPVIRGQ 101 TGRRIKVLNHHGETGDMADF SPDHAIMVDS ALSQQVEILR GPVTLLYSSG 151 NVAGLVDVAD GKIPEKMPENGVSGELGLRL SSGNLEKLTS GGINIGLGKN 201 FVLHTEGLYR KSGDYAVPRY RNLKRLPDSHADSQTGSIGL SWVGEKGFIG 251 AAYSDRRDQY GLPAHSHEYD DCHADIIWQK SLINKRYLQLYPHLLTEEDI 301 DYDNPGLSCG FHDDDDAHAH AHNGKPWIDL RNKRYELRAE WKQPFPGFEA351 LRVHLNRNDY RHDEKAGDAV ENFFNNQTQN ARIELRHQPI GRLKGSWGVQ 401YLGQKSSALS ATSEAVKQPM LLDNKVQHYS FFGVEQANWD NFTLEGGVRV 451 EKQKASIRYDKALIDRENYY NHPLPDLGAH RQTARSFALS GNWYFTPQHK 501 LSLTASHQER LPSTQELYAHGKHVATNTFE VGNKHLNKER SNNIELALGY 551 EGDRWQYNLA LYRNRFGNYI YAQTLNDGRGPKSIEDDSEM KLVRYNQSGA 601 DFYGAEGEIY FKPTPRYRIG VSGDYVRGRL KNLPSLPGREDAYGNRPLIA 651 QADQNAPRVP AARLGVHLKA SLTDRIDANL DYYRVFAQNK LARYETRTPG701 HHMLNLGANY RRNTRYGEWN WYVKADNLLN QSVYAHSSFL SDTPQMGRSF 751 TGGVNVKF*a149-1/m149-1 98.0% identity in 758 aa overlap        10        20        30        40        50        60 a149-1.pepMAQTTLKPIVLSILLINTPLLSQAHGTEQSVGLETVSVVGKSRPRATSGLLHTSTASDKI|||||||||||||||||||||:||| ||||| |||||||||||||||||||||||||||| m149-1MAQTTLKPIVLSILLINTPLLAQAHETEQSVDLETVSVVGKSRPRATSGLLHTSTASDKI        10        20        30        40        50        60        70        80        90       100       110       120 a149-1.pepISGDTLRQKAVNLGDALDGVPGIHASQYGGGASAPVIRGQTGRRIKVLNHHGETGDMADF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m149-1ISGDTLRQKAVNLGDALDGVPGIHASQYGGGASAPVIRGQTGRRIKVLNHHGETGDMADF        70        80        90       100       110       120       130       140       150       160       170       180 a149-1.pepSPDHAIMVDSALSQQVEILRGPVTLLYSSGNVAGLVDVADGKIPEKMPENGVSGELGLRL|||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||| m149-1SPDHAIMVDTALSQQVEILRGPVTLLYSSGNVAGLVDVADGKIPEKMPENGVSGELGLRL       130       140       150       160       170       180       190       200       210       220       230       240 a149-1.pepSSGNLEKLTSGGINIGLGKNFVLHTEGLYRKSGDYAVPRYRNLKRLPDSHADSQTGSIGL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m149-1SSGNLEKLTSGGINIGLGKNFVLHTEGLYRKSGDYAVPRYRNLKRLPDSHADSQTGSIGL       190       200       210       220       230       240       250       260       270       280       290       300 a149-1.pepSWVGEKGFIGAAYSDRRDQYGLPAHSHEYDDCHADIIWQKSLINKRYLQLYPHLLTEEDI||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||| m149-1SWVGEKGFIGVAYSDRRDQYGLPAHSHEYDDCHADIIWQKSLINKRYLQLYPHLLTEEDI       250       260       270       280       290       300       310       320       330       340       350       360 a149-1.pepDYDNPGLSCGFHDDDDAHAHAHNGKPWIDLRNKRYELRAEWKQPFPGFEALRVHLNRNDY|||||||||||||||:||||:|:|:||||||||||||||||||||||||||||||||||| m149-1DYDNPGLSCGFHDDDNAHAHTHSGRPWIDLRNKRYELRAEWKQPFPGFEALRVHLNRNDY       310       320       330       340       350       360       370       380       390       400       410       420 a149-1.pepRHDEKAGDAVENFFNNQTQNARIELRHQPIGRLKGSWGVQYLGQKSSALSATSEAVKQPM|||||||||||||||||||||||||||||||||||||||||| |||||||| |||||||| m149-1RHDEKAGDAVENFFNNQTQNARIELRHQPIGRLKGSWGVQYLQQKSSALSAISEAVKQPM       370       380       390       400       410       420       430       440       450       460       470       480 a149-1.pepLLDNKVQHYSFFGVEQANWDNFTLEGGVRVEKQKASIRYDKALIDRENYYNHPLPDLGAH|||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||| m149-1LLDNKVQHYSFFGVEQANWDNFTLEGGVRVEKQKASIQYDKALIDRENYYNHPLPDLGAH       430       440       450       460       470       480       490       500       510       520       530       540 a149-1.pepRQTARSFALSGNWYFTPQHKLSLTASHQERLPSTQELYAHGKHVATNTFEVGNKHLNKER|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m149-1RQTARSFALSGNWYFTPQHKLSLTASHQERLPSTQELYAHGKHVATNTFEVGNKHLNKER       490       500       510       520       530       540       550       560       570       580       590       600 a149-1.pepSNNIELALGYEGDRWQYNLALYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVRYNQSGA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m149-1SNNIELALGYEGDRWQYNLALYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVRYNQSGA       550       560       570       580       590       600       610       620       630       640       650       660 a149-1.pepDFYGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDAYGNRPLIAQADQNAPRVP|||||||||||||||||||||||||||||||||||||||||||||||:||| |||||||| m149-1DFYGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDAYGNRPFIAQDDQNAPRVP       610       620       630       640       650       660       670       680       690       700       710       720 a149-1.pepAARLGVHLKASLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNTRYGEWN||||| |||||||||||||||||||||||||||||||||||||||||||||||||||||| m149-1AARLGFHLKASLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNTRYGEWN       670       680       690       700       710       720       730       740       750      759 a149-1.pepWYVKADNLLNQSVYAHSSFLSDTPQMGRSFTGGVNVKFX||||||||||||||||||||||||||||||||||||||| m149-1WYVKADNLLNQSVYAHSSFLSDTPQMGRSFTGGVNVKFX        730       740       750The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 607>:

g150.seq (partial) 1 ..TACTGCAAGG CAGACCCCTT TCCCGCCGCC CTGCTGGCCAATCAGAAAAT 51   CACCGCCCGC CAATCCGATA AAGACGTGCG CCACATCGAA ATCGATTTGA101   GCGGTTCGGA TTTGCACTAC CTCCCGGGCG ACGCGCTCGG CGTTTGGTTT 151  GACAACGATC CGGCACTGGT CGGGGAAATC CTAGACCTGC TCGGCATCAA 201  TCCGGCAACG GAAATACAGG CGGGCGGAAA AACCCTGCCG GTTGCCTCCG 251  CACTGTTATC CCATTTCGAA CTCACGCAAA ACACCCCCGC CTTTGTCAAA 301  GGCTATGCCA CGTTCGCCGA TAATGACGAA CTCGACCGTA TTGCTGCCGA 351  CAACGCCGTT TTGCAAGGCT TTGTGCAAAG CACGCCGATT GCCGGTGTGC 401  TGCACCGCTT CCCGGCAAAA CTGACGGCGG AACAATTCGC CGGCCTGCTG 451  CGCCCGCTTG CGCCGCGCCT GTATTCGATT TCCTCGTCGC AGGCGGAAGC 501  GGGGGACGAA GTGCACCTGA CCGTCGGCGC AGTGCGTTTC GAACACGAAG 551  GGCGCGCCAG GGCGGGCGGC GCATCGGGTT TCTTTGCCGA CCGGCTGGAA 601  GAGGACGGCA CGGTGCGCGT GTTTGCGGAA CGCAACGACG GCTTCAGGCT 651  GCCCGAAGAC AGCCGCAAGC CGATTGTGAT GATCGGCTCC GGTACCGGCG 701  TCGCACCGTT CCGCGCCTTC GTCCAACAAC GTGCCGCAGA AAATGCGGAA 751  GGCAGAAACT GGCTGATTTT CGGCAATCCG CATTTTGCCG CCGACTTCCT 801  CTATCAGACC GAATGGCAGC AGTTTGCCAA AGACGGCTTC CTGCACAGAT 851  ATGACTTCGC CTGGTCGCGC GATCAGGAAG AAAAAATCTA TGTGCAGGAC 901  AAAATCCGCG AACAGGCGGA AGGACTTTGG CAATGGCTGC AGGAAGGCGC 951  GCATATCTAT GTGTGCGGCG ATGCGGCAAA AATGGCAAAA GAAGTGGAAG 1001  CCGCCTTGCT GGATGTGATT ATCGGGGCAG GGCATTCGGA CGAAGACGGC 1051  GCAGAAGGAT ATTTGGATAT GCTGCGCGAA GAAAAACGCT ATCAGCGTGA 1101  TGTTTATTGAThis corresponds to the amino acid sequence <SEQ ID 608; ORF 150.ng>:

g150.pep (partial) 1 ..YCKADPFPAA LLANQKITAR QSDKDVRHIE IDLSGSDLHYLPGDALGVWF 51   DNDPALVGEI LDLLGINPAT EIQAGGKTLP VASALLSHFE LTQNTPAFVK101   GYATFADNDE LDRIAADNAV LQGFVQSTPI AGVLHRFPAK LTAEQFAGLL 151  RPLAPRLYSI SSSQAEAGDE VHLTVGAVRF EHEGRARAGG ASGFFADRLE 201  EDGTVRVFAE RNDGFRLPED SRKPIVMIGS GTGVAPFRAF VQQRAAENAE 251  GRNWLIFGNP HFAADFLYQT EWQQFAKDGF LHRYDFAWSR DQEEKIYVQD 301  KIREQAEGLW QWLQEGAHIY VCGDAAKMAK EVEAALLDVI IGAGHSDEDG 351  AEGYLDMLRE EKRYQRDVY*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 609>:

m150.seq 1 ATGCAGAACA CAAATCCGCC ATTACCGCCT CTGCCGCCCG AAATCACGCA 51GCTCCTGTCG GGGCTGGACG CGGCACAATG GGCGTGGCTG TCCGGCTACG 101 CTTGGGCAAAAGCAGGAAAC GGGGCATCTG CAGGACTGCC CGCGCTTCAG 151 ACGGCATTGC CGGCGGCAGAACCTTTTTCC GTAACCGTCC TTTCCGCCTC 201 GCAAACCGGC AATGCGAAAT CCGTTGCCGACAAAGCGGCG GACAGCCTGG 251 AAGCCGCCGG CATCCAAGTC AGTCGCGCCG AACTGAAAGACTATAAGGCG 301 AAAAACATCG CCGGCGAACG CCGCCTGCTG CTGGTTACCT CCACCCAAGG351 CGAAGGCGAA CCGCCGAAAG AAGCCGTCGT GCTGCACAAA CTGCTGAACG 401GCAAAAAAGC CCCGAAATTG GACAAACTCC AATTTGCCGT ACTGGGTTTG 451 GGCGACAGTTCCTATCCGAA TTTCTGTCAG GCAGGTAAAG ATTTCGACCG 501 GCGTTTTGAA GAATTGGGCGCAAAACGGCT GCTCGAACGC GTTGATGCGG 551 ATTTGGACTT TACCGCCTCC GCAAACGCCTGGACAGATAA TATCGCCGCA 601 CTCTTAAAAG AAGAAGCCGC AAAAAACCGG GCAACGCCCGCGCCGCAGAC 651 AACGCCCCCC GCCGGCCTTC AGACGGCACC GGATGGCAGG TACTGCAAGG701 CAGCCCCCTT TCCCGCCGCC CTGCTGGCCA ATCAGAAAAT CACCGCCCGC 751CAATCCGATA AAGACGTGCG CCACATCGAA ATCGATTTGA GCGGTTCGGA 801 TTTGCACTACCTCCCGGGCG ACGCGCTCGG CGTTTGGTTT GACAACGATC 851 CGGCACTGGT CAGGGAAATCCTAGACCTGC TCGGCATCGA TCCGGCAACG 901 GAAATACAGG CGGGCGGAAA GATGATGCCGGTTGCGCGCG CACTTTCATC 951 TCATTTCGAA CTCACGCAAA ACACTCCGGC TTTCGTCAAAGGCTATGCCG 1001 CGTTCGCCCA TTATGAAGAA CTCGATAAAA TCATTGCCGA TAACGCCGTT1051 TTGCAGGATT TCGTGCAAAA CACGCCTATT GTCGATGTGC TGCACCGCTT 1101CCCGGCAAGC CTGACGGCAG AACAATTCAT CCGTTTACTG CGTCCGCTTG 1151 CACCCCGTTTGTATTCGATT TCTTCAGCAC AGGCGGAAGT GGGCGATGAA 1201 GTGCATTTAA CTGTCGGCGTGGTTCGTTTT GAACACGAAG GCCGCGCCAG 1251 AACGGGCGGC GCATCGGGTT TCCTTGCCGACCGGCTGGAA GAGGACGGCA 1301 CGGTGCGCGT GTTTGTGGAA CGCAACGACG GCTTCAGGCTGCCCGAAGAC 1351 AGCCGCAAGC CGATTGTGAT GATCGGCTCG GGCACCGGCG TCGCACCGTT1401 CCGCGCTTTC GTCCAACAAC GTGCCGCAGA AAATGCGGAA GGCAAAAACT 1451GGCTGATTTT CGGCAATCCG CATTTTGCCC GTGATTTTCT CTATCAAACC 1501 GAATGGCAGCAGTTTGCCAA AGACGGCTTC CTGCACAGGT ACGATTTCGC 1551 CTGGTCCCGC GATCAGGAAGAAAAAATCTA TGTGCAGGAC AAAATCCGCG 1601 AACAGGCGGA AGGACTTTGG CAATGGCTGCAGGAAGGCGC GCATATCTAT 1651 GTGTGCGGCG ATGCGGCAAA AATGGCAAAA GACGTGGAAGCCGCCTTGCT 1701 GGATGTGATT ATCGGGGCAG GACATTTGGA CGAAGAGGGC GCAGAAGAAT1751 ATTTGGATAT GCTGCGCGAA GAAAAACGCT ATCAGCGTGA TGTTTATTGAThis corresponds to the amino acid sequence <SEQ ID 610; ORF 150>:

m150.pep 1 MQNTNPPLPP LPPEITQLLS GLDAAQWAWL SGYAWAKAGN GASAGLPALQ 51TALPAAEPFS VTVLSASQTG NAKSVADKAA DSLEAAGIQV SRAELKDYKA 101 KNIAGERRLLLVTSTQGEGE PPKEAVVLHK LLNGKKAPKL DKLQFAVLGL 151 GDSSYPNFCQ AGKDFDRRFEELGAKRLLER VDADLDFTAS ANAWTDNIAA 201 LLKEEAAKNR ATPAPQTTPP AGLQTAPDGRYCKAAPFPAA LLANQKITAR 251 QSDKDVRHIE IDLSGSDLHY LPGDALGVWF DNDPALVREILDLLGIDPAT 301 EIQAGGKMMP VARALSSHFE LTQNTPAFVK GYAAFAHYEE LDKIIADNAV351 LQDFVQNTPI VDVLHRFPAS LTAEQFIRLL RPLAPRLYSI SSAQAEVGDE 401VHLTVGVVRF EHEGRARTGG ASGFLADRLE EDGTVRVFVE RNDGFRLPED 451 SRKPIVMIGSGTGVAPFRAF VQQRAAENAE GKNWLIFGNP HFARDFLYQT 501 EWQQFAKDGF LHRYDFAWSRDQEEKIYVQD KIREQAEGLW QWLQEGAHIY 551 VCGDAAKMAK DVEAALLDVI IGAGHLDEEGAEEYLDMLRE EKRYQRDVY*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 150 shows 91.3% identity over a 369 aa overlap with a predicted ORF(ORF 150.ng) from N. gonorrhoeae:

m150/g150        210       220       230       240       250       260m150.pep LLKEEAAKNRATPAPQTTPPAGLQTAPDGRYCKAAPFPAALLANQKITARQSDKDVRHIE                              |||| ||||||||||||||||||||||||| g150                              YCKADPFPAALLANQKITARQSDKDVRHIE                                      10        20        30       270       280       290       300       310       320 m150.pepIDLSGSDLHYLPGDALGVWFDNDPALVREILDLLGIDPATEIQAGGKMMPVARALSSHFE||||||||||||||||||||||||||| ||||||||:|||||||||| :||| || |||| g150IDLSGSDLHYLPGDALGVWFDNDPALVGEILDLLGINPATEIQAGGKTLPVASALLSHFE        40        50        60        70        80        90       330       340       350       360       370       380 m150.pepLTQNTPAFVKGYAAFAHYEELDKIIADNAVLQDFVQNTPIVDVLHRFPASLTAEQFIRLL|||||||||||||:|| :|||:| ||||||| |||:|||: |||||||:|||||| || g150LTQNTPAFVKGYATFADNDELDRIAADNAVLQGFVQSTPIAGVLHRFPAKLTAEQFAGLL       100       110       120       130       140       150       390       400       410       420       430       440 m150.pepRPLAPRLYSISSAQAEVGDEVHLTVGVVRFEHEGRARTGGASGFLADRLEEDGTVRVFVE||||||||||||:|||:|||||||||:||||||||||:||||||:|||||||||||||:| g150RPLAPRLYSISSSQAEAGDEVHLTVGAVRFEHEGRARAGGASGFFADRLEEDGTVRVFAE       160       170       180       190       200       210       450       460       470       480       490       500 m150.pepRNDGFRLPEDSRKPIVMIGSGTGVAPFRAFVQQRAAENAEGKNWLIFGNPHFARDFLYQT|||||||||||||||||||||||||||||||||||||||||:||||||||||| |||||| g150RNDGFRLPEDSRKPIVMIGSGTGVAPFRAFVQQRAAENAEGRNWLIFGNPHFAADFLYQT       220       230       240       250       260       270       510       520       530       540       550       560 m150.pepEWQQFAKDGFLHRYDFAWSRDQEEKIYVQDKIREQAEGLWQWLQEGAHIYVCGDAAKMAK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g150EWQQFAKDGFLHRYDFAWSRDQEEKIYVQDKIREQAEGLWQWLQEGAHIYVCGDAAKMAK       280       290       300       310       320       330       570       580       590       600 m150.pepDVEAALLDVIIGAGHLDEEGAEEYLDMLREEKRYQRDVYX:|||||||||||||| ||:||| ||||||||||||||||| g150EVEAALLDVIIGAGHSDEDGAEGYLDMLREEKRYQRDVYX       340       350       360       370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 611>:

a150.seq 1 ATGCAGAACA CAAATCCGCC ATTACCGCCT ATGCCGCCCG AAATCACGCA 51GCTCCTGTCG GGGCTGGACG CGGCACAATG GGCGTGGCTG TCCGGCTACG 101 CTTGGGCAAAAGCAGGAAAC GGGGCATCTG CAGGACTGCC CGCGCTTCAG 151 ACGGCATTGC CGACGGCAGAACCTTTTTCC GTAACCGTCC TTTCCGCCTC 201 GCAAACCGGC AATGCGAAAT CCGTTGCCGACAAAGCGGCG GACAGCCTGG 251 AAGCCGCCGG CATCCAAGTC AGTCGCGCCG AACTGAAAGACTATAAGGCG 301 AAAAACATCG CCGGCGAACG CCGCCTGCTG CTGGTTACCT CCACCCAAGG351 CGAAGGCGAA CCGCCGGAAG AAGCCGTCGT GCTGCACAAA CTGCTGAACG 401GCAAAAAAGC CCCGAAATTG GACAAACTCC AATTTGCCGT ACTGGGTTTG 451 GGCGACAGCTCCTATCCGAA TTTCTGCCGG GCGGGCAAAG ATTTCGACAA 501 ACGTTTTGAA GAATTGGGCGCAAAACGCCT GCTCGAACGC GTTGATGCGG 551 ATTTGGACTT TGCCGCCGCC GCAGACGGATGGACAGATAA TATCGCCGCA 601 CTCTTAAAAG AAGAAGCCGC AAAAAACCGG GCAACGCCCGCGCCGCAGAC 651 AACGCCCCCC GCCGGCCTTC AGACGGCACC GGATGGCAGG TACTGCAAGG701 CAGACCCCTT TGCCGCCGCC CTGCTGGCCA ATCAGAAAAT CACCGCCCGC 751CAATCCGATA AAGACGTGCG CCACATCGAA ATCGATTTGA GCGGTTCGGA 801 TTTGCACTACCTCCCGGGCG ACGCGCTCGG CGTTTGGTTT GACAACGATC 851 CGGCACTGGT CAGGGAAATCCTAGACCTGC TCGGCATCGA TCAGGCAACG 901 GAAATACAGG CGGGCGGAAA AACCCTGCCGGTTGCCTCCG CACTGTTATC 951 CCATTTTGAA CTCACGCAAA ACACCCCCGC CTTTGTCAAAGGCTATGCCC 1001 CGTTCGCCGA TGATGACGAA CTCGACCGTA TTGCTGCCGA CAACGCCGTT1051 TTGCAAGGCT TTGTGCAAAG CACGCCGATT GCCGATGTGC TGCACCGCTT 1101CCCGGCAAAA CTGACAGCGG AACAATTCGC CGGCCTACTG CGCCCGCTTG 1151 CGCCGCGCCTGTATTCGATT TCCTCGTCGC AGGCGGAAGT GGGGGACGAA 1201 GTGCACCTGA CCGTCGGCGCGGTGCGTTTC GAACACGAAG GGCGCGCCAG 1251 GGCGGGCGGC GCATCGGGTT TCCTTGCCGACCGGCTGGAA GAGGACGGCA 1301 CGGTGCGCGT GTTTGTGGAA CGCAACGACG GCTTCAGGCTGCCCGAAGAC 1351 AGCCGCAAGC CGATTGTGAT GATCGGCTCG GGCACCGGCG TCGCACCGTT1401 CCGCGCTTTC GTCCAACAAC GTGCCGCAGA AAATGCGGAA GGCAAAAACT 1451GGCTGTTTTT CGGCAATCCG CATTTTGCCC GTGATTTTCT CTATCAAACC 1501 GAATGGCAGCAGTTTGCCAA AGACGGCTTC CTGCACAGAT ACGATTTCGC 1551 CTGGTCGCGC GATCAGGAAGAAAAAATCTA TGTGCAGGAC AAAATCCGCG 1601 AACAGGCGGA AGGACTTTGG CAATGGCTGCAGGAAGGCGC GCATATCTAT 1651 GTGTGCGGCG ATGCGGCAAA AATGGCAAAA GACGTGGAAGCCGCCTTGCT 1701 GGATGTGATT ATCGGGGCAG GACATTTGGA CGAAGAGGGC GCAGAAGAAT1751 ATTTGGATAT GCTGCGCGAA GAAAAACGCT ATCAGCGTGA TGTTTATTGAThis corresponds to the amino acid sequence <SEQ ID 612; ORF 150.a>:

a150.pep 1 MQNTNPPLPP MPPEITQLLS GLDAAQWAWL SGYAWAKAGN GASAGLPALQ 51TALPTAEPFS VTVLSASQTG NAKSVADKAA DSLEAAGIQV SRAELKDYKA 101 KNIAGERRLLLVTSTQGEGE PPEEAVVLHK LLNGKKAPKL DKLQFAVLGL 151 GDSSYPNFCR AGKDFDKRFEELGAKRLLER VDADLDFAAA ADGWTDNIAA 201 LLKEEAAKNR ATPAPQTTPP AGLQTAPDGRYCKADPFPAA LLANQKITAR 251 QSDKDVRHIE IDLSGSDLHY LPGDALGVWF DNDPALVREILDLLGIDQAT 301 EIQAGGKTLP VASALLSHFE LTQNTPAFVK GYAPFADDDE LDRIAADNAV351 LQGFVQSTPI ADVLHRFPAK LTAEQFAGLL RPLAPRLYSI SSSQAEVGDE 401VHLTVGAVRF EHEGRARAGG ASGFLADRLE EDGTVRVFVE RNDGFRLPED 451 SRKPIVMIGSGTGVAPFRAF VQQRAAENAE GKNWLFFGNP HFARDFLYQT 501 EWQQFAKDGF LHRYDFAWSRDQEEKIYVQD KIREQAEGLW QWLQEGAHIY 551 VCGDAAKMAK DVEAALLDVI IGAGHLDEEGAEEYLDMLRE EKRYQRDVY* m150/a150 94.8% identity in 599 aa overlap        10        20        30        40        50        60 m150.pepMQNTNPPLPPLPPEITQLLSGLDAAQWAWLSGYAWAKAGNGASAGLPALQTALPAAEPFS||||||||||:|||||||||||||||||||||||||||||||||||||||||||:||||| a150MQNTNPPLPPMPPEITQLLSGLDAAQWAWLSGYAWAKAGNGASAGLPALQTALPTAEPFS        10        20        30        40        50        60        70        80        90       100       110       120 m150.pepVTVLSASQLGNAKSVADKAADSLEAAGIQVSRAELKDYKAKNIAGERRLLLVTSTQGEGE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a150VTVLSASQLGNAKSVADKAADSLEAAGIQVSRAELKDYKAKNIAGERRLLLVTSTQGEGE        70        80        90       100       110       120       130       140       150       160       170       180 m150.pepPPKEAVVLHKLLNGKKAPKLDKLQFAVLGLGDSSYPNFCQAGKDFDRRFEELGAKRLLER||:||||||||||||||||||||||||||||||||||||:||||||:||||||||||||| a150PPEEAVVLHKLLNGKKAPKLDKLQFAVLGLGDSSYPNFCRAGKDFDKRFEELGAKRLLER       130       140       150       160       170       180       190       200       210       220       230       240 m150.pepVDADLDFLASANAWLDNIAALLKEEAAKNRATPAPQTTPPAGLQTAPDGRYCKAAPFPAA|||||||:|:|::||||||||||||||||||||||||||||||||||||||||| ||||| a150VDADLDFAAAADGWLDNIAALLKEEAAKNRATPAPQTTPPAGLQTAPDGRYCKADPFPAA       190       200       210       220       230       240       250       260       270       280       290       300 m150.pepLLANQKITARQSDKDVRHIEIDLSGSDLHYLPGDALGVWFDNDPALVREILDLLGIDPAT||||||||||||||||||||||||||||||||||||||||||||||||||||||||| || a150LLANQKITARQSDKDVRHIEIDLSGSDLHYLPGDALGVWFDNDPALVREILDLLGIDQAT       250       260       270       280       290       300       310       320       330       340       350       360 m150.pepEIQAGGKMMPVARALSSHFELTQNTPAFVKGYAAFAHYEELDKIIADNAVLQDFVQNTPI||||||| :||| || ||||||||||||||||| ||  :|||:| ||||||| |||:||| a150EIQAGGKTLPVASALLSHFELTQNTPAFVKGYAPFADDDELDRIAADNAVLQGFVQSTPI       310       320       330       340       350       360       370       380       390       400       410       420 m150.pepVDVLHRFPASLTAEQFIRLLRPLAPRLYSISSAQAEVGDEVHLTVGVVRFEHEGRARTGG:||||||||:|||||| ||||||||||||||:|||||||||||||:||||||||||:|| a150ADVLHRFPAKLTAEQFAGLLRPLAPRLYSISSSQAEVGDEVHLTVGAVRFEHEGRARAGG       370       380       390       400       410       420       430       440       450       460       470       480 m150.pepASGFLADRLEEDGTVRVFVERNDGFRLPEDSRKPIVMIGSGTGVAPFRAFVQQRAAENAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a150ASGFLADRLEEDGTVRVFVERNDGFRLPEDSRKPIVMIGSGTGVAPFRAFVQQRAAENAE       430       440       450       460       470       480       490       500       510       520       530       540 m150.pepGKNWLIFGNPHFARDFLYQTEWQQFAKDGFLHRYDFAWSRDQEEKIYVQDKIREQAEGLW|||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||| a150GKNWLFFGNPHFARDFLYQTEWQQFAKDGFLHRYDFAWSRDQEEKIYVQDKIREQAEGLW       490       500       510       520       530       540       550       560       570       580       590       600 m150.pepQWLQEGAHIYVCGDAAKMAKDVEAALLDVIIGAGHLDEEGAEEYLDMLREEKRYQRDVYX|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a150QWLQEGAHIYVCGDAAKMAKDVEAALLDVIIGAGHLDEEGAEEYLDMLREEKRYQRDVYX       550       560       570       580       590       600The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 613>:

g151.seq 1 ATGAAACAAA TCCGCAACAT CGCCATCATC GCACACGTCG ACCACGGCAA 51AACCACATTG GTCGACCAAC TGCTGCGCCA ATCCGGCACA TTCCGCGCCA 101 ACCAGCAGGTTGACGAGCGC GTGATGGACA GCAACGACCT TGAAAAAGAA 151 CGCGGCATCA CCATCCTCGCCAAAAACACC GCCATCGATT ACGAAGGCTG 201 CCACATCAAT ATCGTCGACA CGCCGGGACACGCCGACTTC GGCGGCGAAG 251 TGGAGCGCGT TTTGGGGATG GTGGATTGCG TCGTCTTGTTGGTGGACGCA 301 CAGGAAGGTC CGATGCCGCA AACCCGTTTC GTGACCAAAA AAGCCTTGGC351 TTTGGGGCTG AAACCGATTG TCGTCATCAA CAAAATCGAC AAACCGTCCG 401CCCGTCCGAG CTGGGTTATC GACCAGACTT TCGAGTTGTT CGACAACTTG 451 GGTGCGACCGACGAGCAGTT GGATTTCCCG ATTGTTTACG CTTCAGGTTT 501 GAGCGGCTTT GCCAAGCTGGAAGAAAccga CGAGAGCAGC GATATGCGCC 551 CGCtgttcgA CACCATCCTA AAATACAcgcctgCACCGAG CGGCAGCGCG 601 GACGAGCCGC TGCAACTGCA AATTTCCCAA CTCGACTACGACAACTACAC 651 CGGCCGCCTC GGTATCGGTC GTATCTTGAA CGGACGCATC AAACCCGGCC701 AAACCGTTGC CGTGATGAAC CACGAGCAGC AAATCGCCCA AGGCCGCATC 751AACCAGCTTT TGGGTTTCAA AGGCTTGGAA CGCGTGCCGC TTGAAGAAGC 801 CGAAGCCGGCGACATTGTGA TTATTTCCGG TATCGAAGAC ATCGGCATCG 851 GCGTAACCAT CACCGACAAAGACAACCCCA AAGGCCTGCC GATGTTGAGC 901 GTGGACGAAC CGACGCTGAC GATGGACTTTATGGTAAACA CCAGCCCGCT 951 CGCAGGTACA GAAGGCAAAT TCGTGACCAG CCGCCAAATCCGCGACCGCC 1001 TGCAAAAAGA ATTGCTGACC AACGTTGCCC TGCGCGTGGA AGACACCGCC1051 GatgCCGACG TGTTCCGCGT ATCcgGGCGC GGCGAACTGC ACCTGACGAT 1101TTTGCTGGAA AATATGCGCC GCGAAGGCTA CGAACTCGCC GTCGGCAAGC 1151 CGCGCGTCGTGTACCGAGAC ATCGACGGTC AAAAATGCGA ACCTTATGAA 1201 AACCTGACTG TGGACGTACccgacgacAAC CAAGGCGCGG TAATGGAAGA 1251 ACTCGGCCGC CGCCGTGGCG AACTGACCAATATGGAAAGC GACGGCAACG 1301 GacgCACCCG CCTCGAATAC CATATTCCAG CGCGCGGCTTGATCGGTTTC 1351 CAAGGCGAAT TCATGACCCT GACGCGCGGC GTCGGGCTGA TGAgccacGT1401 GTTcgacgac tacgcgcccg tcaAACCCGA TATGCCCGGC CGCCACAACG 1451GCGTactggt GtcccaAGAG CAGGGCGAGG CGGTTGCTTA CGCCTTGTGG 1501 AATCTTGAAGACCGCGGCCG TATGTTCGTA TCGCCCAACG ACAAAATCTA 1551 CGAAGGTATG ATTATCGGCATCCACAGCCG CGACAACGAT TTGGTGGTCA 1601 ACCCGCTCAA AGGCAAAAAA CTCACCAATATCCGTGCCAG CGGTACCGAC 1651 GAAGCGGTGC GCCTGACCAC GCCGATCAAA CTGAcgcTGGAAGGCGCGGT 1701 CGAGTTTATC GACGATGACG AGCTGGTGGA AATCACGCCG CAAtccatcc1751 gcctgcgcat gcgttacctG AGCGaattgg aacgccgccg tcaTTTTAAA 1801AagctgGATT AAThis corresponds to the amino acid sequence <SEQ ID 614; ORF 151.ng>:

g151.pep 1 MKQIRNIAII AHVDHGKTTL VDQLLRQSGT FRANQQVDER VMDSNDLEKE 51RGITILAKNT AIDYEGCHIN IVDTPGHADF GGEVERVLGM VDCVVLLVDA 101 QEGPMPQTRFVTKKALALGL KPIVVINKID KPSARPSWVI DQTFELFDNL 151 GATDEQLDFP IVYASGLSGFAKLEETDESS DMRPLFDTIL KYTPAPSGSA 201 DEPLQLQISQ LDYDNYTGRL GIGRILNGRIKPGQTVAVMN HEQQIAQGRI 251 NQLLGFKGLE RVPLEEAEAG DIVIISGIED IGIGVTITDKDNPKGLPMLS 301 VDEPTLTMDF MVNTSPLAGT EGKFVTSRQI RDRLQKELLT NVALRVEDTA351 DADVFRVSGR GELHLTILLE NMRREGYELA VGKPRVVYRD IDGQKCEPYE 401NLTVDVPDDN QGAVMEELGR RRGELTNMES DGNGRTRLEY HIPARGLIGF 451 QGEFMTLTRGVGLMSHVFDD YAPVKPDMPG RHNGVLVSQE QGEAVAYALW 501 NLEDRGRMFV SPNDKIYEGMIIGIHSRDND LVVNPLKGKK LTNIRASGTD 551 EAVRLTTPIK LTLEGAVEFI DDDELVEITPQSIRLRMRYL SELERRRHFK 601 KLD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 615>:

m151.seq 1 ATGAAACAAA TCCGCAACAT CGCCATCATC GCCCACGTCG ACCACGGCAA 51AACCACATTG GTCGACCAAC TGCTGCGCCA ATCCGGCACA TTCCGCGCCA 101 ACCAGCAGGTTGACGAGCGC GTGATGGACA GCAACGACCT TGAAAAAGAA 151 CGCGGCATCA CCATCCTCGCCAAAAACACC GCCATCGATT ACGAAGGCTA 201 CCACATCAAT ATCGTCGACA CGCCGGGACACGCCGACTTC GGCGGCGAAG 251 TAGAGCGCGT TTTGGGGATG GTGGACTGCG TCGTCTTGTTGGTGGACGCG 301 CAGGAAGGCC CGATGCCGCA AACCCGTTTC GTGACCAAAA AAGCCTTGGC351 TTTGGGGCTG AAACCGATTG TCGTCATCAA CAAAATCGAC AAGCCGTCCG 401CTCGTCCGAG CTGGGTTATC GACCAAACTT TCGAGCTGTT CGACAACTTG 451 GGCGCGACCGACGAGCAGTT GGATTTCCCG ATTGTTTACG CTTCAGGGTT 501 GAGCGGTTTC GCCAAATTGGAAGAAACCGA CGAGAGCAAC GACATGCGTC 551 CGCTGTTCGA TACTATCTTA AAATATACGCCTGCACCGAG CGGCAGCGCG 601 GACGAAACGC TGCAACTGCA AATTTCCCAA CTCGACTACGACAACTACAC 651 CGGCCGCCTC GGTATCGGTC GTATCTTGAA CGGACGCATC AAACCCGGCC701 AAACCGTTGC CGTCATGAAC CACGATCAGC AAATCGCCCA AGGCCGCATC 751AACCAGCTTT TGGGTTTCAA AGGTTTGGAA CGCGTGCCGC TTGAAGAAGC 801 CGAAGCCGGCGACATCGTGA TTATTTCCGG TATCGAAGAC ATCGGTATCG 851 GCGTAACCAT CACCGACAAAGACAATCCCA AAGGCCTACC GATGTTGAGC 901 GTGGACGAAC CGACGCTGAC GATGGACTTTATGGTCAACA CCAGCCCGCT 951 GGCGGGTACG GAAGGCAAAT TCGTAACCAG CCGCCAAATCCGCGACCGCC 1001 TGCAAAAAGA ATTGCTGACC AACGTCGCCC TGCGCGTGGA AGATACCGCC1051 GATGCCGACG TGTTCCGCGT ATCCGGGCGC GGCGAGCTGC ACCTGACCAT 1101TTTGCTGGAA AACATGCGCC GCGAAGGCTA CGAACTCGCC GTCGGCAAAC 1151 CGCGCGTCGTGTACCGCGAC ATCGACGGTC AAAAATGCGA ACCGTATGAA 1201 AACCTGACCG TGGATGTACCCGACGACAAC CAAGGCGCGG TAATGGAAGA 1251 ACTCGGCCGC CGCCGTGGCG AACTGACTAATATGGAAAGC GACGGCAACG 1301 GACGCACCCG CCTCGAATAC CATATTCCAG CGCGCGGCTTGATCGGTTTC 1351 CAAGGCGAAT TTATGACCCT GACGCGCGGG GTCGGGCTGA TGAGCCACGT1401 GTTCGACGAT TACGCGCCCG TCAAACCCGA TATGCCCGGC CGCCACAACG 1451GCGTGCTGGT GTCCCAAGAG CAGGGCGAGG CAGTCGCTTA CGCCTTGTGG 1501 AATCTGGAAGACCGCGGCCG TATGTTCGTA TCGCCCAACG ACAAAATCTA 1551 CGAAGGCATG ATTATCGGCATCCACAGTCG CGACAACGAT TTGGTGGTCA 1601 ACCCGCTCAA AGGCAAAAAA CTTACCAACATCCGTGCCAG CGGTACCGAC 1651 GAAGCCGTTC GCCTGACCAC GCCAATCAAG CTGACGCTGGAAGGTGCGGT 1701 TGAGTTTATC GACGATGACG AACTCGTTGA AATCACGCCG CAATCCATCC1751 GTCTGCGCAA GCGTTACTTG AGCGAATTGG AACGCCGCCG CCACTTTAAA 1801AAGCTGGATT GAThis corresponds to the amino acid sequence <SEQ ID 616; ORF 151>:

m151.pep 1 MKQIRNIAII AHVDHGKTTL VDQLLRQSGT FRANQQVDER VMDSNDLEKE 51RGITILAKNT AIDYEGYHIN IVDTPGHADF GGEVERVLGM VDCVVLLVDA 101 QEGPMPQTRFVTKKALALGL KPIVVINKID KPSARPSWVI DQTFELFDNL 151 GATDEQLDFP IVYASGLSGFAKLEETDESN DMRPLFDTIL KYTPAPSGSA 201 DETLQLQISQ LDYDNYTGRL GIGRILNGRIKPGQTVAVMN HDQQIAQGRI 251 NQLLGFKGLE RVPLEEAEAG DIVIISGIED IGIGVTITDKDNPKGLPMLS 301 VDEPTLTMDF MVNTSPLAGT EGKFVTSRQI RDRLQKELLT NVALRVEDTA351 DADVFRVSGR GELHLTILLE NMRREGYELA VGKPRVVYRD IDGQKCEPYE 401NLTVDVPDDN QGAVMEELGR RRGELTNMES DGNGRTRLEY HIPARGLIGF 451 QGEFMTLTRGVGLMSHVFDD YAPVKPDMPG RHNGVLVSQE QGEAVAYALW 501 NLEDRGRMFV SPNDKIYEGMIIGIHSRDND LVVNPLKGKK LTNIRASGTD 551 EAVRLTTPIK LTLEGAVEFI DDDELVEITPQSIRLRKRYL SELERRRHFK 601 KLD*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 151 shows 99.2% identity over a 603 aa overlap with a predicted ORF(ORF 151.ng) from N. gonorrhoeae:

m151/g151         10        20        30        40        50        60m151.pep MKQIRNIAIIAHVDHGKTTLVDQLLRQSGTFRANQQVDERVMDSNDLEKERGITILAKNT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g151MKQIRNIAIIAHVDHGKITLVDQLLRQSGTFRANQQVDERVMDSNDLEKERGITILAKNT        10        20        30        40        50        60        70        80        90       100       110       120 m151.pepAIDYEGYHINIVDTPGHADFGGEVERVLGMVDCVVLLVDAQEGPMPQTRFVTKKALALGL|||||| ||||||||||||||||||||||||||||||||||||||||||||||||||||| g151AIDYEGCHINIVDTPGHADFGGEVERVLGMVDCVVLLVDAQEGPMPQTRFVTKKALALGL        70        80        90       100       110       120       130       140       150       160       170       180 m151.pepKPIVVINKIDKPSARPSWVIDQTFELFDNLGAIDEQLDFPIVYASGLSGFAKLEETDESN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: g151KPIVVINKIDKPSARPSWVIDQTFELFDNLGAIDEQLDFPIVYASGLSGFAKLEETDESS       130       140       150       160       170       180       190       200       210       220       230       240 m151.pepDMRPLFDTILKYTPAPSGSADETLQLQISQLDYDNYTGRLGIGRILNGRIKPGQTVAVMN|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| g151DMRPLFDTILKYTPAPSGSADEPLQLQISQLDYDNYTGRLGIGRILNGRIKPGQTVAVMN       190       200       210       220       230       240       250       260       270       280       290       300 m151.pepHDQQIAQGRINQLLGFKGLERVPLEEAEAGDIVIISGIEDIGIGVTITDKDNPKGLPMLS|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g151HEQQIAQGRINQLLGFKGLERVPLEEAEAGDIVIISGIEDIGIGVTITDKDNPKGLPMLS       250       260       270       280       290       300       310       320       330       340       350       360 m151.pepVDEPTLTMDFMVNTSPLAGTEGKFVTSRQIRDRLQKELLTNVALRVEDTADADVFRVSGR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g151VDEPTLTMDFMVNTSPLAGTEGKFVTSRQIRDRLQKELLTNVALRVEDTADADVFRVSGR       310       320       330       340       350       360       370       380       390       400       410       420 m151.pepGELHLTILLENMRREGYELAVGKPRVVYRDIDGQKCEPYENLTVDVPDDNQGAVMEELGR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g151GELHLTILLENMRREGYELAVGKPRVVYRDIDGQKCEPYENLTVDVPDDNQGAVMEELGR       370       380       390       400       410       420       430       440       450       460       470       480 m151.pepRRGELTNMESDGNGRTRLEYHIPARGLIGFQGEFMTLTRGVGLMSHVFDDYAPVKPDMPG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g151RRGELTNMESDGNGRTRLEYHIPARGLIGFQGEFMTLTRGVGLMSHVFDDYAPVKPDMPG       430       440       450       460       470       480       490       500       510       520       530       540 m151.pepRHNGVLVSQEQGEAVAYALWNLEDRGRMFVSPNDKIYEGMIIGIHSRDNDLVVNPLKGKK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 8151RHNGVLVSQEQGEAVAYALWNLEDRGRMFVSPNDKIYEGMIIGIHSRDNDLVVNPLKGKK       490       500       510       520       530       540       550       560       570       580       590       600 m151.pepLTNIRASGTDEAVRLTTPIKLTLEGAVEFIDDDELVEITPQSIRLRKRYLSELERRRHFK|||||||||||||||||||||||||||||||||||||||||||||| ||||||||||||| g151LTNIRASGTDEAVRLTTPIKLTLEGAVEFIDDDELVEITPQSIRLRMRYLSELERRRHFK       550       560       570       580       590       600 m151.pepKLDX |||| 8151 KLDXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 617>:

a151.seq 1 ATGAAACAAA TCCGCAACAT CGCCATCATC GCCCACGTCG ACCACGGCAA 51AACCACATTG GTCGACCAAC TGCTGCGCCA ATCCGGCACA TTCCGCGCCA 101 ACCAGCAGGTTGACGAGCGC GTGATGGACA GCAACGACCT TGAAAAAGAA 151 CGCGGCATCA CCATCCTCGCCAAAAACACC GCCATCGATT ACGAAGGCTA 201 CCACATCAAT ATCGTCGACA CGCCGGGACACGCCGACTTC GGCGGCGAAG 251 TAGAGCGAGT TTTGGGGATG GTGGACTGCG TCGTCTTGTTGGTGGACGCG 301 CAGGAAGGCC CGATGCCGCA AACCCGTTTC GTGACCAAAA AAGCCTTGGC351 TTTGGGGCTG AAACCGATTG TCGTCATCAA TAAAATCGAC AAACCGTCCG 401CCCGTCCGAG CTGGGTCATC GACCAAACTT TCGAGCTGTT CGACAACTTG 451 GGCGCGACCGACGAGCAGTT GGATTTCCCG ATTGTTTATG CTTCCGGTCT 501 GTCCGGTTTC GCCAAATTGGAAGAAACCGA CGAGAGCAAC GACATGCGTC 551 CGCTGTTCGA TACTATCTTA AAATATACGCCTGCACCGAG CGGCAGCGCG 601 GACGAAACGC TGCAACTGCA AATTTCCCAA CTCGACTACGACAACTACAC 651 CGGCCGCCTC GGTATCGGTC GTATCTTGAA CGGACGTATC AAGCCCGGTC701 AAGTTGTTGC CGTCATGAAC CACGATCAAC AAATCGCCCA AGGCCGCATC 751AACCAGCTTT TGGGTTTCAA AGGTTTAGAA CGCGTGCCGC TTGAAGAAGC 801 CGAAGCCGGCGACATCGTGA TTATTTCCGG TATTGAAGAC ATCGGCATCG 851 GCGTAACCAT CACCGACAAAGACAACCCCA AAGGCCTGCC GATGTTGAGC 901 GTGGACGAAC CGACGCTGAC GATGGACTTTATGGTCAACA CCAGCCCGTT 951 GGCAGGTACG GAAGGCAAAT TCGTAACCAG CCGCCAAATCCGCGACCGCC 1001 TGCAAAAAGA ATTGCTGACC AACGTCGCCC TGCGCGTGGA AGATACCGCC1051 GATGCCGACG TGTTCCGCGT ATCCGGGCGC GGCGAGCTGC ACCTGACCAT 1101TTTGCTGGAA AACATGCGCC GCGAAGGCTA CGAACTCGCC GTCGGCAAAC 1151 CGCGCGTCGTGTACCGCGAC ATCGACGGTC AAAAATGCGA ACCGTATGAA 1201 AACCTGACCG TGGACGTACCCGACGACAAC CAAGGCGCGG TAATGGAAGA 1251 ACTCGGCCGC CGCCGTGGCG AACTGACTAATATGGAAAGC GACGGCAACG 1301 GACGCACCCG CCTCGAATAC CATATTCCAG CGCGCGGCTTGATCGGCTTC 1351 CAAGGCGAAT TTATGACCCT GACGCGCGGG GTCGGGCTGA TGAGCCACGT1401 GTTCGACGAT TACGCGCCCG TCAAACCCGA TATGCCTGGC CGCCACAACG 1451GCGTGCTGGT GTCCCAAGAG CAGGGCGAGG CAGTCGCTTA CGCCTTGTGG 1501 AATCTGGAAGACCGCGGCCG TATGTTCGTA TCGCCCAACG ACAAAATCTA 1551 CGAAGGTATG ATTATCGGCATCCACAGTCG CGACAACGAT TTGGTGGTCA 1601 ACCCGCTCAA AGGCAAAAAA CTTACCAACATCCGTGCCAG CGGTACCGAC 1651 GAAGCCGTTC GCCTGACCAC GCCGATTAAG CTGACGCTGGAAGGTGCGGT 1701 CGAGTTTATC GACGATGATG AGCTGGTAGA AATCACGCCG CAATCCATCC1751 GTCTGCGCAA GCGTTACTTG AGCGAATTGG AACGCCGCCG CCATTTCAAA 1801AAGCTAGATT GAThis corresponds to the amino acid sequence <SEQ ID 618; ORF 151.a>:

a151.pep 1 MKQIRNIAII AHVDHGKTTL VDQLLRQSGT FRANQQVDER VMDSNDLEKE 51RGITILAKNT AIDYEGYHIN IVDTPGHADF GGEVERVLGM VDCVVLLVDA 101 QEGPMPQTRFVTKKALALGL KPIVVINKID KPSARPSWVI DQTFELFDNL 151 GATDEQLDFP IVYASGLSGFAKLEETDESN DMRPLFDTIL KYTPAPSGSA 201 DETLQLQISQ LDYDNYTGRL GIGRILNGRIKPGQVVAVMN HDQQIAQGRI 251 NQLLGFKGLE RVPLEEAEAG DIVIISGIED IGIGVTITDKDNPKGLPMLS 301 VDEPTLTMDF MVNTSPLAGT EGKFVTSRQI RDRLQKELLT NVALRVEDTA351 DADVFRVSGR GELHLTILLE NMRREGYELA VGKPRVVYRD IDGQKCEPYE 401NLTVDVPDDN QGAVMEELGR RRGELTNMES DGNGRTRLEY HIPARGLIGF 451 QGEFMTLTRGVGLMSHVFDD YAPVKPDMPG RHNGVLVSQE QGEAVAYALW 501 NLEDRGRMFV SPNDKIYEGMIIGIHSRDND LVVNPLKGKK LTNIRASGTD 551 EAVRLTTPIK LTLEGAVEFI DDDELVEITPQSIRLRKRYL SELERRRHFK 601 KLD* m151/a151 99.8% identity in 603 aaoverlap         10        20        30        40        50        60m151.pep MKQIRNIAIIAHVDHGKTTLVDQLLRQSGTFRANQQVDERVMDSNDLEKERGITILAKNT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a151MKQIRNIAIIAHVDHGKTTLVDQLLRQSGTFRANQQVDERVMDSNDLEKERGITILAKNT        10        20        30        40        50        60        70        80        90       100       110       120 m151.pepAIDYEGYHINIVDTPGHADFGGEVERVLGMVDCVVLLVDAQEGPMPQTRFVTKKALALGL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a151AIDYEGYHINIVDTPGHADFGGEVERVLGMVDCVVLLVDAQEGPMPQTRFVTKKALALGL        70        80        90       100       110       120       130       140       150       160       170       180 m151.pepKPIVVINKIDKPSARPSWVIDQTFELFDNLGATDEQLDFPIVYASGLSGFAKLEETDESN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a151KPIVVINKIDKPSARPSWVIDQTFELFDNLGATDEQLDFPIVYASGLSGFAKLEETDESN       130       140       150       160       170       180       190       200       210       220       230       240 m151.pepDMRPLFDTILKYTPAPSGSADETLQLQISQLDYDNYTGRLGIGRILNGRIKPGQTVAVMN||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| a151DMRPLFDTILKYTPAPSGSADETLQLQISQLDYDNYTGRLGIGRILNGRIKPGQVVAVMN       190       200       210       220       230       240       250       260       270       280       290       300 m151.pepHDQQIAQGRINQLLGFKGLERVPLEEAEAGDIVIISGIEDIGIGVTITDKDNPKGLPMLS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a151HDQQIAQGRINQLLGFKGLERVPLEEAEAGDIVIISGIEDIGIGVTILDKDNPKGLPMLS       250       260       270       280       290       300       310       320       330       340       350       360 m151.pepVDEPTLTMDFMVNTSPLAGTEGKFVTSRQIRDRLQKELLTNVALRVEDTADADVFRVSGR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a151VDEPTLTMDFMVNTSPLAGTEGKFVTSRQIRDRLQKELLTNVALRVEDTADADVFRVSGR       310       320       330       340       350       360       370       380       390       400       410       420 m151.pepGELHLTILLENMRREGYELAVGKPRVVYRDIDGQKCEPYENLTVDVPDDNQGAVMEELGR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a151GELHLTILLENMRREGYELAVGKPRVVYRDIDGQKCEPYENLTVDVPDDNQGAVMEELGR       370       380       390       400       410       420       430       440       450       460       470       480 m151.pepRRGELTNMESDGNGRTRLEYHIPARGLIGFQGEFMTLTRGVGLMSHVFDDYAPVKPDMPG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a151RRGELTNMESDGNGRTRLEYHIPARGLIGFQGEFMTLTRGVGLMSHVFDDYAPVKPDMPG       430       440       450       460       470       480       490       500       510       520       530       540 m151.pepRHNGVLVSQEQGEAVAYALWNLEDRGRMFVSPNDKIYEGMIIGIHSRDNDLVVNPLKGKK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a151RHNGVLVSQEQGEAVAYALWNLEDRGRMFVSPNDKIYEGMIIGIHSRDNDLVVNPLKGKK       490       500       510       520       530       540       550       560       570       580       590       600 m151.pepLTNIRASGTDEAVRLTTPIKLTLEGAVEFIDDDELVEITPQSIRLRKRYLSELERRRHFK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a151LTNIRASGTDEAVRLTTPIKLTLEGAVEFIDDDELVEITPQSIRLRKRYLSELERRRHFK       550       560       570       580       590       600 m151.pepKLDX |||| a151 KLDXThe following partial DNA sequence was identified in N.gonorrhoeae <SEQID 619>:

g152.seq 1 ATGAAAAaca aAACCaaagt ctgGGacttc cCcacccgcc ttTTCCactG 51GctgcttgCC gCATCCctgc CCTTTATGTG gtatagCGCA AAAGCCGGCG 101 GcgataTGCTGcaatgGCAC ACGCGCGTCG GGCTGCTCGT CCTTTTCCTG 151 CTCGTATTCC GCCTCTGCTGGGGCATTTGG GGCAgcgATA CCGCCCGTTT 201 CTCccgTtTC GTCCGAGGTT GGGCAGGTATACGCGGCTAT CTGAAAAAcg 251 gCATTCCCGA ACAtatcCAG CCCGGACACA ACCCCTTGGGCGCACTgatg 301 gtcGTTGCGC TTTTGgccgc cgtcTCATTT CAagtcggcA CGGGGCTTTT351 Tgccgccaat gaaaacacct tcagcaCCAa cggctacctc aaccatttgg 401tttccgaaca tacgGGCAGC CTTATACGGA AAATCCACCT CAACTTTTTC 451 AAGCTGCTCGCCGTTTTTTC CGCAGTCCAC ATCGCCGCCG TCGCCGCATA 501 CCGCATATTC AAAAAGAAAAACCTCGTCCG CCCGATGATA ACCGGCTTCA 551 AATACATCGA AGGCAAAACC TCAATCCGCTTTGCCGGCAA AGCCGCGCTT 601 GCCGCCGCAT TATCGGTTGC CGCGCTTGCC GCAGCCGCCATCCTGCTCCT 651 GTCCTGAThis corresponds to the amino acid sequence <SEQ ID 620; ORF 152.ng>:

g152.pep 1 MKNKTKVWDF PTRLFHWLLA ASLPFMWYSA KAGGDMLQWH TRVGLLVLFL 51LVFRLCWGIW GSDTARFSRF VRGWAGIRGY LKNGIPEHIQ PGHNPLGALM 101VVALLAAVSF QVGTGLFAAN ENTFSTNGYL NHLVSEHTGS LIRKIHLNFF 151KLLAVFSAVH IAAVAAYRIF KKKNLVRPMI TGFKYIEGKT SIRFAGKAAL 201AAALSVAALA AAAILLLS*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 621>:

m152.seq 1 ATGAAAAACA AAACCAAAGT CTGGGACCTC CCCACCCGCC TTTTCCACTG 51GCTGCTTGCC GCGTCCCTGC CCTTTATGTG GTATAGCGCG AAAGCCGGCG 101 GCGATATGCTGCAATGGCAC ACGCGCGTCG GGCTGTTCGT CCTTTTCCTG 151 CTCGTATTTC GCCTCTGCTGGGGCATTTGG GGCAGCGATA CCGCCCGTTT 201 TTCCCGTTTC GTCCAAGGCT GGGCAGGCATACGCGGCTAT CTGAAAAACG 251 GTATTCCCGA ACACATCCAG CCCGGACACA ACCCCTTGGGCGCACTGATG 301 GTCGTTGCGC TTTTGGCCGC CGTGTCCTTC CAAGTCGGCA CCGGGCTTTT351 TGCCGCCGAT GAAAACACCT TCAGCACCAA CGGCTACCTC AACCATTTGG 401TTTCCGAACA TACGGGCAGC CTTATGCGGA AAATCCACCT CAACTTTTTC 451 AAGCTGCTCGCCGTTTTTTC TGCAATCCAC ATCGCCGCCG TCGCCGCATA 501 CCGCGTATTC AAAAAGAAAAACCTCATCCT CCCGATGATA ACCGGCTTCA 551 AATACATCGA AGGCAAAACC TCAATCCGCTTTGCAGGCAA AGCCGCGCTT 601 GCCGCCGCAT TATCGGTTGC CTCGCTTGCC GCAGCCGCCATCCTGCTCCT 651 GTCCTGAThis corresponds to the amino acid sequence <SEQ ID 622; ORF 152>:

m152.pep 1 MKNKTKVWDL PTRLFHWLLA ASLPFMWYSA KAGGDMLQWH TRVGLFVLFL 51LVFRLCWGIW GSDTARFSRF VQGWAGIRGY LKNGIPEHIQ PGHNPLGALM 101VVALLAAVSF QVGTGLFAAD ENTFSTNGYL NHLVSEHTGS LMRKIHLNFF 151KLLAVFSAIH IAAVAAYRVF KKKNLILPMI TGFKYIEGKT SIRFAGKAAL 201AAALSVASLA AAAILLLS*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 152 shows 95.4% identity over a 218 aa overlap with a predicted ORF(ORF 152.ng) from N. gonorrhoeae:

m152/g152         10        20        30        40        50        60m152.pep MKNKTKVWDLPTRLFHWLLAASLPFMWYSAKAGGDMLQWHTRVGLFVLFLLVFRLCWGIW|||||||||:||||||||||||||||||||||||||||||||||||:||||||||||||| g152MKNKTKVWDFPTRLFHWLLAASLPFMWYSAKAGGDMLQWHTRVGLLVLFLLVFRLCWGIW        10        20        30        40        50        60        70        80        90       100       110       120 m152.pepGSDTARFSRFVQGWAGIRGYLKNGIPEHIQPGHNPLGALMVVALLAAVSFQVGTGLFAAD|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||: 8152GSDTARFSRFVRGWAGIRGYLKNGIPEHIQPGHNPLGALMVVALLAAVSFQVGTGLFAAN        70        80        90       100       110       120       130       140       150       160       170       180 m152.pepENTFSTNGYLNHLVSEHTGSLMRKIHLNFFKLLAVFSAIHIAAVAAYRVFKKKNLILPMI|||||||||||||||||||||:||||||||||||||||:|||||||||:||||||: ||| g152ENTFSTNGYLNHLVSEHTGSLIRKIHLNFFKLLAVFSAVHIAAVAAYRIFKKKNLVRPMI       130       140       150       160       170       180       190       200       210      219 m152.pepTGFKYIEGKTSIRFAGKAALAAALSVASLAAAAILLLSX|||||||||||||||||||||||||||:||||||||||| g152TGFKYIEGKTSIRFAGKAALAAALSVAALAAAAILLLSX        190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 623>:

a152.seq 1 ATGAAAAACA AAACCAAAGT CTGGGACTTC CCCACCCGCC TTTTCCACTG 51GCTGCTTGCC GCATCCCTAC CCTTTATGTG GTATAGCGCG AAAACCGGCG 101 GCGATATGCTGCAATGGCAC ACGCGCGTCG GGCTGTTTAT CCTTTTCCTG 151 CTCGTATTCC GCCTCTGCTGGGGCATTTGG GGCAGCGATA CCGCCCGTTT 201 CTCCCGTTTC GTCCGCGGAT GGTCGGGTATCAGAGAGTAT ATGAAAAACG 251 GTATTCCCGA ACACGTCCAA CCCGGACACA ACCCCTTGGGCGCACTGATG 301 GTCGTTGCGC TTTTGGCCGC CGTGTCGTTC CAAGTCGGCA CAGGGCTTTT351 TGCCGCCGAT GTAAACACCT TCAGCACCAA CGGCTACCTC AACCATTTGG 401TTTCCGAACA TACGGGCAGC CTTATGCGGA AAATCCATCT CAACTTTTTC 451 AAACTGCTCGCCGTTTTTTC CGCAGTCCAC ATCGCCGNCG TCGCCGCATA 501 CCGCGTGTTC AAAAAGAAAAACCTCGTCCT CCCGATGATA ACCGGCTTCA 551 AATACATCGA AGGCAAAACC TCAATCCGCTTTGCCGGCAA AGCCGCGCTT 601 GCCGCCGCAT TATCGGTTGC CGCGCTTGCC GCAGCCGCCATCCTGCTCCT 651 GTCCTGAThis corresponds to the amino acid sequence <SEQ ID 624; ORF 152.a>:

a152.pep 1 MKNKTKVWDF PTRLFHWLLA ASLPFMWYSA KTGGDMLQWH TRVGLFILFL 51LVFRLCWGIW GSDTARFSRF VRGWSGIREY MKNGIPEHVQ PGHNPLGALM 101VVALLAAVSF QVGTGLFAAD VNTFSTNGYL NHLVSEHTGS LMRKIHLNFF 151KLLAVFSAVH IAXVAAYRVF KKKNLVLPMI TGFKYIEGKT SIRFAGKAAL 201AAALSVAALA AAAILLLS* m152/a152 94.0% identity in 218 aa overlap        10        20        30        40        50        60 m152.pepMKNKTKVWDLPTRLFHWLLAASLPFMWYSAKAGGDMLQWHTRVGLFVLFLLVFRLCWGIW|||||||||:|||||||||||||||||||||:||||||||||||||:||||||||||||| a152MKNKTKVWDFPTRLFHWLLAASLPFMWYSAKTGGDMLQWHTRVGLFILFLLVFRLCWGIW        10        20        30        40        50        60        70        80        90       100       110       120 m152.pepGSDTARFSRFVQGWAGIRGYLKNGIPEHIQPGHNPLGALMVVALLAAVSFQVGTGLFAAD|||||||||||:||:||| |:|||||||:||||||||||||||||||||||||||||||| a152GSDTARFSRFVRGWSGIREYMKNGIPEHVQPGHNPLGALMVVALLAAVSFQVGTGLFAAD        70        80        90       100       110       120       130       140       150       160       170       180 m152.pepENTFSTNGYLNHLVSEHTGSLMRKIHLNFFKLLAVFSAIHIAAVAAYRVFKKKNLILPMI|||||||||||||||||||||||||||||||||||||:||| ||||||||||||:|||| a152VNTFSTNGYLNHLVSEHTGSLMRKIHLNFFKLLAVFSAVHIAXVAAYRVFKKKNLVLPMI       130       140       150       160       170       180       190       200       210      219 m152.pepTGFKYIEGKTSIRFAGKAALAAALSVASLAAAAILLLSX|||||||||||||||||||||||||||:||||||||||| a152TGFKYIEGKTSIRFAGKAALAAALSVAALAAAAILLLSX        190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 625>:

g153.seq 1 atggggtttg cttaCAgtat gacgtatatc gaggtCGGGa taccggaggc 51ggcatccgtc ctttCgctGC CCGAGATgat gcgcctgatG GTGTTtCagg 101 attATGGTTTTttggcCGAA GTGATGTTTG TGctgaCTTT cGGCGcgcCG 151 GTTCTGTTtC TGCTGCTGTGCCTGTATGTC TATGCCGCGC TGATACGGAA 201 ACAGGCGTAT CCTGCGCTGC GTTTGGCAACGCGTGTGATG GTGCGCTTGA 251 GGCAGGCGAT GATGGTGGAT GTGTTTTTTG TTTCCACTCTGGTGGCGTAT 301 ATCAAGCTCT CGTCTGTGGC AAAGGTTCGC TTCGGGCCGG CGTTTTATCT351 GATGTTCGCG CTGTCGGTTA TGCTGATTCG GACTTCGGTA TCGGTTCCCC 401AGCATTGGGT GTATTTCCAA ATCGGGCGGC TGACGGGGAA TAATGCGGTT 451 CAGACGGCATCGGAAGGCAA AACCTGTTGC AGCCGCTGCC TGTATTTccg 501 cgacAGTgcc gaatccCCCTGCGGGGTGTg cgGCGcggaA CTgtacggcg 551 gacggccgaa aagtCTGAGt atttCgtCGGCGTTTCTgac ggcggcggTT 601 GTTTTGTATT TCCctgCcaa TATCctgccg attaTGAtttcgtccAATCc 651 tgccgccacg GAGGcCAACA CCATCTTTAG CGGCATCGCT TATATGTGGG701 ACGagggcgA CAGGCTGATT GCGGCGGTTA TTTTCAGCGC GAGTATTTTG 751GTGCCGGTGC TGAAGATTGC GGCAATGTCG GTTTTGATTG CGGCGGCACG 801 GTTCGCTTTGCCGGCGGGCG CAAAGAAATT GTCGCACCTC tacCGCATCA 851 CCGAAGCGGT CGGCCGCTGGTCGATGATTG ATATTTTTGT GATTATTATT 901 TTGATGTGTT CGTTCCacaC TTATGCCGCGCGCGTCATTC CGGGCAGTGC 951 GGCAGTCTAT TTCTGCCTGG TCGTGATTTT GACGATGCTGTCCGCCTATT 1001 ATTTCGACCC GCGCCTGCTT TGGGACAAAC GCGCTTCAGA CGGCATTGCT1051 TTCAACGAAA CGGAAAAATA TGACTGAThis corresponds to the amino acid sequence <SEQ ID 626; ORF 153.ng>:

g153.pep 1 MGFAYSMTYI EVGIPEAASV LSLPEMMRLM VFQDYGFLAE VMFVLTFGAP 51VLFLLLCLYV YAALIRKQAY PALRLATRVM VRLRQAMMVD VFFVSTLVAY 101 IKLSSVAKVRFGPAFYLMFA LSVMLIRTSV SVPQHWVYFQ IGRLTGNNAV 151 QTASEGKTCC SRCLYFRDSAESPCGVCGAE LYGGRPKSLS ISSAFLTAAV 201 VLYFPANILP IMISSNPAAT EANTIFSGIAYMWDEGDRLI AAVIFSASIL 251 VPVLKIAAMS VLIAAARFAL PAGAKKLSHLYRITEAVGRW SMIDIFVIII 301 LMCSFHTYAA RVIPGSAAVY FCLVVILTML SAYYFDPRLLWDKRASDGIA 351 FNETEKYD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 627>:

m153.seq 1 ATGGCGTTTG CTTACGGTAT GACGTATATC GAGGTCGGGA TACCGGGTGC 51GGCATCCGTC CTTTCGCTGC CCGAGATGAT GCGCCTGATG GTGTTTCAGG 101 ATTATGGTTTTTTGGCCGAA GTGATGTTTG TGCTGACTTT CGGCGCGCCG 151 GTTCTGTTTC TGCTGCTGTGCCTGTATGTC TATGCCGCGC TGATACGGAA 201 ACAGGCGTAT CCTGCGCTGC GTTTGGCAACGCGTGTGATG GTGCGCTTGA 251 GACAGGCGAT GATGGTGGAT GTGTTTTTTG TTTCCACTTTGGTGGCGTAT 301 ATCAAGCTCT CGTCTGTGGC AGAGGTTCGC TTCGGGCCGG CGTTTTATCT351 GATGTTCGCG CTGTCAGTTA TGCTGATTCG GACTTCGGTA TCGGTTCCCC 401AGCATTGGGT GTATTTTCAA ATCGGGCGGC TGACGGGGGA TAATGCGGTT 451 CAGACGGCATCGGAAGGTAA AACCTGTTGC AGCCGCTGCC TGTATTTCCG 501 CGACAGTGCC GAATCCCCCTGCGGCGTGTG CGGTGCGGAA CTGTACCGCC 551 GACGGCCGAA AAGTCTGAGT ATTTCGTCGGCGTTTCTGAC GGCGGCGGTT 601 ATTTTGTATT TCCCTGCCAA TATCCTGCCG ATTATGATTTCGTCCAATCC 651 TGCCGCCACG GAGGTCAATA CCATCCTTAA CGGCATCGCT TATATGTGGG701 ACGAGGGCGA CAGGCTGATT GCGGCGGTTA TTTTCAGCGC GAGTATTTTG 751GTGCCGGTAC TGAAGATTGC GGCAATGTCG GTTTTGATTG CGTCCGCCCG 801 CTTCGCTTTGCCAACGGGTG CAAAGAAATT GTCGCACCTC TACCGCATCA 851 CCGAAGCGGT CGGCCGCTGGTCGATGATTG ATATTTTTGT GATTATTATT 901 TTGATGTGTT CGTTCCACAC TTATGCCGCGCGCGTCATTC CGGGCAGTGC 951 GGCAGTCTAT TTCTGCCTGG TCGTGATTCT GACGATGCTGTCCGCCTATT 1001 ATTTCGACCC GCGCCTGCTT TGGGACAAAC GCGCTTCAGA CGGCATTGCT1051 TTCAATGAAA CGGAAAAACA TGACTGAThis corresponds to the amino acid sequence <SEQ ID 628; ORF 153>:

m153.pep 1 MAFAYGMTYI EVGIPGAASV LSLPEMMRLM VFQDYGFLAE VMFVLTFGAP 51VLFLLLCLYV YAALIRKQAY PALRLATRVM VRLRQAMMVD VFFVSTLVAY 101 IKLSSVAEVRFGPAFYLMFA LSVMLIRTSV SVPQHWVYFQ IGRLTGDNAV 151 QTASEGKTCC SRCLYFRDSAESPCGVCGAE LYRRRPKSLS ISSAFLTAAV 201 ILYFPANILP IMISSNPAAT EVNTILNGIAYMWDEGDRLI AAVIFSASIL 251 VPVLKIAAMS VLIASARFAL PTGAKKLSHLYRITEAVGRW SMIDIFVIII 301 LMCSFHTYAA RVIPGSAAVY FCLVVILTML SAYYFDPRLLWDKRASDGIA 351 FNETEKHD* m153/g153 96.1% identity in 358 aa overlap        10        20        30        40        50        60 m153.pepMAFAYGMLYIEVGIPGAASVLSLPEMMRLMVFQDYGFLAEVMFVLTFGAPVLFLLLCLYV|:|||:||||||||| |||||||||||||||||||||||||||||||||||||||||||| g153MGFAYSMTYIEVGIPEAASVLSLPEMMRLMVFQDYGFLAEVMFVLTFGAPVLFLLLCLYV        10        20        30        40        50        60        70        80        90       100       110       120 m153.pepYAALIRKQAYPALRLATRVMVRLRQAMMVDVFFVSTLVAYIKLSSVAEVRFGPAFYLMFA|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||| g153YAALIRKQAYPALRLATRVMVRLRQAMMVDVFFVSTLVAYIKLSSVAKVRFGPAFYLMFA        70        80        90       100       110       120       130       140       150       160       170       180 m153.pepLSVMLIRTSVSVPQHWVYFQIGRLTGDNAVQTASEGKTCCSRCLYFRDSAESPCGVCGAE||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| g153LSVMLIRTSVSVPQHWVYFQIGRLTGNNAVQTASEGKTCCSRCLYFRDSAESPCGVCGAE       130       140       150       160       170       180       190       200       210       220       230       240 m153.pepLYRRRPKSLSISSAFLTAAVILYFPANILPIMISSNPAATEVNTILNGIAYMWDEGDRLI|| ||||||||||||||||:||||||||||||||||||||:|||::||||||||||||| g153LYGGRPKSLSISSAFLTAAVVLYFPANILPIMISSNPAATEANTIFSGIAYMWDEGDRLI       190       200       210       220       230       240       250       260       270       280       290       300 m153.pepAAVIFSASILVPVLKIAAMSVLIASARFALPTGAKKLSHLYRITEAVGRWSMIDIFVIII||||||||||||||||||||||||:||||||:|||||||||||||||||||||||||||| g153AAVIFSASILVPVLKIAAMSVLIAAARFALPAGAKKLSHLYRITEAVGRWSMIDIFVIII       250       260       270       280       290       300       310       320       330       340       350      359 m153.pepLMCSFHTYAARVIPGSAAVYFCLVVILTMLSAYYFDPRLLWDKRASDGIAFNETEKHDX||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| g153LMCSFHTYAARVIPGSAAVYFCLVVILTMLSAYYFDPRLLWDKRASDGIAFNETEKYDX       310       320       330       340       350The following partial DNA sequence was identified in N. meningitidis<SEQ ID 629>:

a153.seq 1 ATGGCGTTTG CTTACGGTAT GACGTATATC GAGGTCGGGA TACCGGGTGC 51GGCATCCGTC CTTTCGCTGC CCGAGATGAT GCGCCTGATG GTGTTTCAGG 101 ATTATGGTTTTTTGGCCGAA GTGATGTTTG TGCTGACCTT CGGCGCGCCG 151 GTTCTGTTTC TGCTGCTGTGCCTGTATGTC TATGCCGCGC TGATACGGAA 201 ACAGGCGTAT CCTGCGCTGC GTTTGGCAACGCGTGTGATG GTGCGCTTGA 251 GACAGGCGAT GATGGTGGAT GTGTTTTTTG TTTCCACTTTGGTGGCGTAT 301 ATCAAGCTCT CGTCTGTGGC AGAGGTTCGC TTCGGATCGG CGTTTTATCT351 GATGTTCGCG CTGTCGGTTA TGCTGATTCG GACTTCGGTA TCGGTTCCCC 401AGCATTGGGT GTATTTTCAA ATCGGGCGGC TGACGGGGGA TAATGCGGTT 451 CAGACGGCATCGGAAGGTAA AACCTGTTGC AGCCGCTGCC TGTATTTCCG 501 CGACAGTGCC GAATCCCCCTGCGGCGTGTG CGGTGCGGAA CTGTACCGCC 551 GACGGCCGAA AAGTCTGAGT ATTTCGTCGGCGTTTCTGAC GGCGGCGGTT 601 ATTTTGTATT TCCCTGCCAA TATCCTGCCG ATTATGATTTCGTCCAATCC 651 TGCCGCCACG GAGGTCAATA CCATCCTTAA CGGCATCGCT TATATGTGGG701 ACGAGGGCGA CAGGCTGATT GCGGCGGTTA TTTTCAGCGC GAGTATTTTG 751GTGCCGGTAC TGAAGATTGC GGCAATGTCG GTTTTGATTG CGTCCGCCCG 801 CTTCGCTTTGCCAACGGGTG CAAAGAAATT GTCGCACCTC TACCGCATCA 851 CCGAAGCGGT CGGCCGCTGGTCGATGATTG ATATTTTTGT GATTATTATT 901 TTGATGTGTT CGTTCCACAC TTATGCCGCGCGCGTCATTC CGGGCAGTGC 951 GGCAGTCTAT TTCTGCCTGG TCGTGATTCT GACGATGCTGTCCGCCTATT 1001 ATTTCGACCC GCGCCTGCTT TGGGACAAAC GCGCTTCAGA CGGCATTGCT1051 TTCAATGAAA CGGAAAAACA TGACTGAThis corresponds to the amino acid sequence <SEQ ID 630; ORF 153.a>:

a153.pep 1 MAFAYGMTYI EVGIPGAASV LSLPEMMRLM VFQDYGFLAE VMFVLTFGAP 51VLFLLLCLYV YAALIRKQAY PALRLATRVM VRLRQAMMVD VFFVSTLVAY 101 IKLSSVAEVRFGSAFYLMFA LSVMLIRTSV SVPQHWVYFQ IGRLTGDNAV 151 QTASEGKTCC SRCLYFRDSAESPCGVCGAE LYRRRPKSLS ISSAFLTAAV 201 ILYFPANILP IMISSNPAAT EVNTILNGIAYMWDEGDRLI AAVIFSASIL 251 VPVLKIAAMS VLIASARFAL PTGAKKLSHLYRITEAVGRW SMIDIFVIII 301 LMCSFHTYAA RVIPGSAAVY FCLVVILTML SAYYFDPRLLWDKRASDGIA 351 FNETEKHD* m153/a153 99.7% identity in 358 aa overlap        10        20        30        40        50        60 m153.pepMAFAYGMTYIEVGIPGAASVLSLPEMMRLMVFQDYGFLAEVMFVLTFGAPVLFLLLCLYV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a153MAFAYGMTYIEVGIPGAASVLSLPEMMRLMVFQDYGFLAEVMFVLTFGAPVLFLLLCLYV        10        20        30        40        50        60        70        80        90       100       110       120 m153.pepYAALIRKQAYPALRLATRVMVRLRQAMMVDVFFVSTLVAYIKLSSVAEVRFGPAFYLMFA|||||||||||||||||||||||||||||||||||||||||||||||||||| ||||||| a153YAALIRKQAYPALRLATRVMVRLRQAMMVDVFFVSTLVAYIKLSSVAEVRFGSAFYLMFA        70        80        90       100       110       120       130       140       150       160       170       180 m153.pepLSVMLIRTSVSVPQHWVYFQIGRLIGDNAVQTASEGKICCSRCLYFRDSAESPCGVCGAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a153LSVMLIRTSVSVPQHWVYFQIGRLIGDNAVQTASEGKICCSRCLYFRDSAESPCGVCGAE       130       140       150       160       170       180       190       200       210       220       230       240 m153.pepLYRRRPKSLSISSAFLTAAVILYFPANILPIMISSNPAATEVNTILNGIAYMWDEGDRLI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a153LYRRRPKSLSISSAFLTAAVILYFPANILPIMISSNPAATEVNTILNGIAYMWDEGDRLI       190       200       210       220       230       240       250       260       270       280       290       300 m153.pepAAVIFSASILVPVLKIAAMSVLIASARFALPTGAKKLSHLYRITEAVGRWSMIDIFVIII|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a153AAVIFSASILVPVLKIAAMSVLIASARFALPTGAKKLSHLYRITEAVGRWSMIDIFVIII       250       260       270       280       290       300       310       320       330       340       350      359 m153.pepLMCSFHTYAARVIPGSAAVYFCLVVILTMLSAYYFDPRLLWDKRASDGIAFNETEKHDX||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a153LMCSFHTYAARVIPGSAAVYFCLVVILTMLSAYYFDPRLLWDKRASDGIAFNETEKHDX       310       320       330       340       350The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 631>:

g154.seq 1 ATGACTGACA ACAGCCCTCC TCCAAACGGA CACGCTCAAG CACGCGTCCG 51CAAAAACAAC accttcctCT CCGCCGTCTG GCTGGTCCCG CTGATCGCGC 101 TGATTGCCGGCGGCTGGCTT TGGGTTAAGG AAATCCGCAA CAGGGGGCCT 151 GTGGTTACGC TCTTGATGGACAGCGCGGAA GGCATCGAAG TCAACAATAC 201 GGTCATTAAG GTATTGAGCA TCGATGTCGGACGCGTTACC CGAATCAAAC 251 TGCGCGACGA CCAAAAAGGC GTGGAAGTTA CTGCCCAACTCAATGCGGAC 301 GTATCCGGCC TCATCCGCAG CGATACCCAG TTTTGGGTGG TCAAGCCGCG351 TATCGACCAA AGCGGcgtAA CCGGTTTGGG TACGCTGCTT TCGGGTTCGT 401ACATCGCTTT TACACCCGGC AAAAGCGGCG AGGCAAAAGA CGTGTTCCAA 451 GTGCAGGACATTCCGCCCGT TACCGCCATC GGGCAAAgcg GGCTGCGCTT 501 GAATTTGATT GGTAAAAACGAccgCATCCT CAACGTcaaC AGCCCTGTTT 551 TGTATGAAAA CTTTATGGTC GGGCAAATCGAAAGCGCGCA TTTCGAcccG 601 TCCGACCAAA GCGTGCATTA CACCATCTTC ATCCAAAGCCCCAACGACAA 651 ACTGATTCAT TCCGCCAGCC GTTTTTGGCT GGAAAGCGGC ATCAATATCG701 AAACCACAGG CAGCGGCATC AAACTCAATT CCGCCCCTCT GCCTGCCCTG 751CTGTCAGGCG CGATTTCATT TGATTCGCCG AAAACCAAAA ACAGTAAAAA 801 CGTCAAAAGCGAGGACAGCT TCACGCTTTA CGACAGCCGC AGCGAAATCG 851 CCAACCTGCC TGACGACCGCTCGCTGTACT ACACCGCGTT TTTCAAACAA 901 TCCGTGCGCG GACTGACCGT cggTTCGCCTGTcgaATACA AAGGGCtgaA 951 TGTcggCATG GTTTCCGATG TCCCTTATTT TGACCGCAAtgacagCCTGC 1001 ACCtgtTTGA aaacggctgg aTTcccGtac gCATCCGCAT cgagccTTCC1051 CGTTTGGAAA TCAATGCCGA CGAGCAAAGC AAAGAGCATT GGAAACAACA 1101ATTCCAGACG GCCTTAAACA AAGGCCTGAC CGCCACCATC TCCAGCAACA 1151 ACCTGCTGACCGGCGGCAAA ATGATTGAGT TGAACGATCA GCCTTCCGCC 1201 TCGCCCAAGC TGCGACCGCATACCGTTTAT GCAGGCGATA CCGTCATCGC 1251 CACACGGGGC GGCGGTTTGG ATGACTTGCAGGTCAAATTG GCGGATTTGC 1301 TGGACaaatT CAACAATCTG CCATTggata aAACCGTTGCCGAATTGAAC 1351 GGCTCGCTCG CCGAACTCAA GTCCGCACTC AAATCCGCCA ATGCCGCCCT1401 AAGCTCCATT GacaAACTGG TCGgcaaTCC GCAGACGCAA AACATCCCGA 1451ACGAACTGAA CCAAACTCTG AAAGAGTTGC GCATAACCCT GCAAGGCGTA 1501 TCGcctCAATCGCCTATCTa cgGAgacgta caAAATAcgc tgCaAAGTTT 1551 GGACAAAACC TTAAAagacgTtcaACCCGT CATTAACACT TTGAaAGAAa 1601 aacCCaaCgc actGATTTtc aacaACAGCAGCAAAGAccc tATCCCGAAA 1651 GGAAGCCGAT AAThis corresponds to the amino acid sequence <SEQ ID 632; ORF 154.ng>:

g154.pep 1 MTDNSPPPNG HAQARVRKNN TFLSAVWLVP LIALIAGGWL WVKEIRNRGP 51VVTLLMDSAE GIEVNNTVIK VLSIDVGRVT RIKLRDDQKG VEVTAQLNAD 101 VSGLIRSDTQFWVVKPRIDQ SGVTGLGTLL SGSYIAFTPG KSGEAKDVFQ 151 VQDIPPVTAI GQSGLRLNLIGKNDRILNVN SPVLYENFMV GQIESAHFDP 201 SDQSVHYTIF IQSPNDKLIH SASRFWLESGINIETTGSGI KLNSAPLPAL 251 LSGAISFDSP KTKNSKNVKS EDSFTLYDSR SEIANLPDDRSLYYTAFFKQ 301 SVRGLTVGSP VEYKGLNVGM VSDVPYFDRN DSLHLFENGW IPVRIRIEPS351 RLEINADEQS KEHWKQQFQT ALNKGLTATI SSNNLLTGGK MIELNDQPSA 401SPKLRPHTVY AGDTVIATRG GGLDDLQVKL ADLLDKFNNL PLDKTVAELN 451 GSLAELKSALKSANAALSSI DKLVGNPQTQ NIPNELNQTL KELRITLQGV 501 SPQSPIYGDV QNTLQSLDKTLKDVQPVINT LKEKPNALIF NNSSKDPIPK 551 GSR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 633>:

m154.seq 1 ATGACTGACA ACAGCCCTCC TCCAAACGGA CACGCCCAAG CACGCGTCCG 51CAAAAACAAC ACCTTCCTCT CTGCCGTCTG GCTGGTTCCG CTGATCGCGC 101 TGATTGCCGGCGGCTGGCTT TGGGTTAAGG AAATCCGCAA CAGGGGGCCT 151 GTGGTTACGC TCTTGATGGACAGCGCGGAA GGCATTGAGG TCAACAATAC 201 GGTCATCAAA GTATTGAGCA TCGATGTCGGACGCGTTACC CGAATCAAAC 251 TGCGCGACGA CCAAAAAGGC GTGGAAGTAA CCGCCCAACTCAATGCGGAC 301 GTATCCGGCC TCATCCGCAG CGATACCCAG TTTTGGGTGG TCAAGCCGCG351 TATCGACCAA AGCGGCGTAA CCGGTTTGGG TACGCTGCTT TCGGGTTCGT 401ACATCGCCTT TACACCCGGC AAAAGCGACG AGGCAAAAGA CGTGTTCCAA 451 GTGCAGGACATTCCGCCCGT TACCGCCATC GGGCAAAGCG GGCTGCGCTT 501 GAATTTGATT GGTAAAAACGACCGCATCCT CAACGTCAAC AGCCCTGTTT 551 TGTATGAAAA TTTTATGGTC GGGCAAGTCGAAAGCGCGCA TTTCGACCCG 601 TCCGACCAAA GCGTGCATTA CACCATCTTC ATCCAAAGCCCCAACGACAA 651 ACTGATTCAT TCCGCCAGCC GTTTTTGGCT GGAAAGCGGC ATCAATATCG701 AAACCACAGG CAGCGGCATC AAACTCAATT CCGCCCCTCT GCCTGCCCTG 751CTGTCGGGCG CGATTTCATT TGATTCGCCG AAAACCAAAA ACAGTAAAAA 801 CGTCAAAAGCGAAGACAGCT TCACGCTTTA CGACAGCCGC AGCGAAGTCG 851 CCAACCTGCC TGACGACCGCTCGCTGTACT ACACCGCGTT TTTCAAACAA 901 TCCGTGCGCG GCCTGACCGT CGGTTCGCCCGTCGAGTACA AAGGGCTGAA 951 TGTCGGCGTG GTTTCCGACG TTCCTTATTT CGACCGCAACGACAGCCTGC 1001 ACCTGTTTGA AAACGGCTGG ATACCCGTAC GCATCCGCAT TGAACCTTCC1051 CGTTTGGAAA TCAATGCCGA CGAACAAAGC AAAGAACATT GGAAACAACA 1101ATTTCAGACG GCCTTAAACA AAGGCCTGAC CGCCACCATC TCCAGCAACA 1151 ACCTGCTGACCGGAAGCAAA ATGATTGAGT TGAACGATCA GCCTTCCGCA 1201 TCACCTAAGC TGCGACCGCATACCGTTTAT GCAGGCGATA CCGTTATCGC 1251 GACCCAGGGC GGCGGTTTGG ACGATTTGCAGGTCAAATTG GCGGATTTGC 1301 TGGACAAGTT CGACAAACTG CCTTTAGATA AGACGGTTGCCGAATTGAAC 1351 GGTTCGCTTG CCGAGCTCAA ATCCACACTC AAATCTGCCA ATGCCGCCCT1401 AAGCTCCATC GACAAACTGG TCGGCAAACC GCAGACACAA AACATTCCGA 1451ACGAACTGAA CCAAACCCTG AAAGAGTTGC GCACAACCCT GCAAGGCGTA 1501 TCGCCGCAATCGCCTATCTA CGGCGACGTA CAAAATACGC TGCAAAGTTT 1551 GGACAAAACT TTAAAAGACGTTCAACCCGT GATTAATACT TTGAAAGAAA 1601 AACCCAACGC GCTGATTTTC AACAGCAGCAGCAAAGACCC TATCCCGAAA 1651 GGAAGCCGAT AAThis corresponds to the amino acid sequence <SEQ ID 634 ORF 154.a>:

m154.pep 1 MTDNSPPPNG HAQARVRKNN TFLSAVWLVP LIALIAGGWL WVKEIRNRGP 51VVTLLMDSAE GIEVNNTVIK VLSIDVGRVT RIKLRDDQKG VEVTAQLNAD 101 VSGLIRSDTQFWVVKPRIDQ SGVTGLGTLL SGSYIAFTPG KSDEAKDVFQ 151 VQDIPPVTAI GQSGLRLNLIGKNDRILNVN SPVLYENFMV GQVESAHFDP 201 SDQSVHYTIF IQSPNDKLIH SASRFWLESGINIETTGSGI KLNSAPLPAL 251 LSGAISFDSP KTKNSKNVKS EDSFTLYDSR SEVANLPDDRSLYYTAFFKQ 301 SVRGLTVGSP VEYKGLNVGV VSDVPYFDRN DSLHLFENGW IPVRIRIEPS351 RLEINADEQS KEHWKQQFQT ALNKGLTATI SSNNLLTGSK MIELNDQPSA 401SPKLRPHTVY AGDTVIATQG GGLDDLQVKL ADLLDKFDKL PLDKTVAELN 451 GSLAELKSTLKSANAALSSI DKLVGKPQTQ NIPNELNQTL KELRTTLQGV 501 SPQSPIYGDV QNTLQSLDKTLKDVQPVINT LKEKPNALIF NSSSKDPIPK 551 GSR* m154/g154 97.8% identity in553 aa overlap        10        20        30        40        50        60 m154.pepMTDNSPPPNGHAQARVRKNNTFLSAVWLVPLIALIAGGWLWVKEIRNRGPVVTLLMDSAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g154MTDNSPPPNGHAQARVRKNNTFLSAVWLVPLIALIAGGWLWVKEIRNRGPVVTLLMDSAE        10        20        30        40        50        60        70        80        90       100       110       120 m154.pepGIEVNNTVIKVLSIDVGRVTRIKLRDDQKGVEVTAQLNADVSGLIRSDTQFWVVKPRIDQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g154GIEVNNTVIKVLSIDVGRVTRIKLRDDQKGVEVTAQLNADVSGLIRSDTQFWVVKPRIDQ        70        80        90       100       110       120       130       140       150       160       170       180 m154.pepSGVTGLGTLLSGSYIAFTPGKSDEAKDVFQVQDIPPVTAIGQSGLRLNLIGKNDRILNVN|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| g154SGVTGLGTLLSGSYIAFTPGKSGEAKDVFQVQDIPPVTAIGQSGLRLNLIGKNDRILNVN       130       140       150       160       170       180       190       200       210       220       230       240 m154.pepSPVLYENFMVGQVESAHFDPSDQSVHYTIFIQSPNDKLIHSASRFWLESGINIETTGSGI||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| g154SPVLYENFMVGQIESAHFDPSDQSVHYTIFIQSPNDKLIHSASRFWLESGINIETTGSGI       190       200       210       220       230       240       250       260       270       280       290       300 m154.pepKLNSAPLPALLSGAISFDSPKTKNSKNVKSEDSFTLYDSRSEVANLPDDRSLYYTAFFKQ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||| g154KLNSAPLPALLSGAISFDSPKTKNSKNVKSEDSFTLYDSRSEIANLPDDRSLYYTAFFKQ       250       260       270       280       290       300       310       320       330       340       350       360 m154.pepSVRGLTVGSPVEYKGLNVGVVSDVPYFDRNDSLHLFENGWIPVRIRIEPSRLEINADEQS|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||| g154SVRGLTVGSPVEYKGLNVGMVSDVPYFDRNDSLHLFENGWIPVRIRIEPSRLEINADEQS       310       320       330       340       350       360       370       380       390       400       410       420 m154.pepKEHWKQQFQTALNKGLTATISSNNLLTGSKMIELNDQPSASPKLRPHTVYAGDTVIATQG||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||:| g154KEHWKQQFQTALNKGLTATISSNNLLTGGKMIELNDQPSASPKLRPHTVYAGDTVIATRG       370       380       390       400       410       420       430       440       450       460       470       480 m154.pepGGLDDLQVKLADLLDKFDKLPLDKTVAELNGSLAELKSTLKSANAALSSIDKLVGKPQTQ|||||||||||||||||::|||||||||||||||||||:||||||||||||||||:|||| g154GGLDDLQVKLADLLDKFNNLPLDKTVAELNGSLAELKSALKSANAALSSIDKLVGNPQTQ       430       440       450       460       470       480       490       500       510       520       530       540 m154.pepNIPNELNQTLKELRTTLQGVSPQSPIYGDVQNTLQSLDKTLKDVQPVINTLKEKPNALIF|||||||||||||| ||||||||||||||||||||||||||||||||||||||||||||| g154NIPNELNQTLKELRITLQGVSPQSPIYGDVQNTLQSLDKTLKDVQPVINTLKEKPNALIF       490       500       510       520       530       540        550m154.pep NSSSKDPIPKGSRX |:|||||||||||| g154 NNSSKDPIPKGSRX        550The following partial DNA sequence was identified in N. meningitidis<SEQ ID 635>:

a154.seq 1 ATGACTGACA ACAGCCCTCC TCCAAACGGA CACGCCCAAG CACGCGTCCG 51CAAAAACAAC ACCTTCCTCT CTGCCGTCTG GCTGGTTCCG CTGATCGCGC 101 TGATTGCCGGCGGCTGGCTT TGGGTTAAGG AAATCCGCAA CAGGGGGCCT 151 GTGGTTACGC TCTTGATGGACAGCGCGGAA GGCATTGAGG TCAACAATAC 201 GGTCATCAAA GTATTGAGCA TCGATGTCGGACGCGTTACC CGAATCAAAC 251 TGCGCGACGA CCAAAAAGGC GTGGAAGTAA CCGCCCAACTCAATGCGGAC 301 GTATCCGGCC TCATCCGCAG CGATACCCAG TTTTGGGTGG TCAAGCCGCG351 TATCGACCAA AGCGGCGTAA CCGGTTTGGG TACGCTGCTT TCGGGTTCGT 401ACATCGCCTT TACACCCGGC AAAAGCGACG AGGCAAAAGA CGTGTTCCAA 451 GTGCAGGACATTCCGCCCGT TACCGCCATC GGGCAAAGCG GGCTGCGCTT 501 GAATTTGATT GGTAAAAACGACCGCATCCT CAACGTCAAC AGCCCTGTTT 551 TGTATGAAAA CTTTATGGTC GGGCAAGTCGAAAGCGCGCA TTTCGACCCG 601 TCCGACCAAA GCGTGCATTA CACCATCTTC ATCCAAAGCCCCAACGACAA 651 ACTGATTCAT TCCGCCAGCC GTTTCTGGCT GGAAAGCGGC ATCAATATCG701 AAACCACAGG CAGCGGCATC AAACTCAATT CCGCCCCTCT GCCTGCCCTG 751CTGTCGGGCG CGATTTCATT TGATTCGCCG AAAACCAAAA ACAGTAAAAA 801 CGTCAAAAGCGAAGACAGCT TCACGCTTTA CGACAGCCGC AGCGAAGTCG 851 CCAACCTGCC TGATGACCGTTCGCTGTACT ACACCGCGTT TTTCAAACAA 901 TCCGTGCGCG GACTGACCGT CGGTTCGCCTGTCGAGTACA AAGGGCTGAA 951 TGTCGGCGTG GTTTCCGATG TTCCTTATTT CGACCGCAACGACAGCCTGC 1001 ACCTGTTTGA AAACGGCTGG ATTCCCGTAC GCATCCGTAT TGAGCCTTCC1051 CGTTTGGAAA TCAATGCCGA CGAACAAAGC AAAGAACATT GGAAACAACA 1101ATTTCAGACG GCCTTAAACA AAGGCCTGAC CGCCACCATC TCCAGCAACA 1151 ACCTGCTGACCGGCAGCAAA ATGATTGAGT TGAACGATCA GCCTTCCGCC 1201 TCGCCCAAGC TGCGACCGCATACCGTTTAT GCAGGCGATA CCGTTATCGC 1251 GACCCAGGGC GGCGGTTTGG ACGATTTGCAGGTCAAATTG GCGGATTTGC 1301 TGGACAAGTT CGACAAACTG CCTTTAGATA AGACGGTTGCCGAATTGAAC 1351 GGTTCGCTTG CCGAGCTCAA ATCCACACTC AAATCTGCCA ATGCCGCCCT1401 AAGCTCCATC GACAAACTGG TCGGCAAACC GCAGACACAA AACATTCCGA 1451ACGAACTGAA CCAAACCCTG AAAGAGTTGC GCACAACCCT GCAAGGCGTA 1501 TCGCCTCAATCGCCTATCTA CGGCGACGTA CAAAATACGC TGCAAAGTTT 1551 GGACAAAACC TTAAAAGACGTTCAACCCGT CATTAACACT TTGAAAGAAA 1601 AACCCAACGC GCTGATTTTC AACAGCAGCAGCAAAGACCC TATCCCGAAA 1651 GGAAGCCGAT AAThis corresponds to the amino acid sequence <SEQ ID 636; ORF 154.a>:

a154.pep 1 MTDNSPPPNG HAQARVRKNN TFLSAVWLVP LIALIAGGWL WVKEIRNRGP 51VVTLLMDSAE GIEVNNTVIK VLSIDVGRVT RIKLRDDQKG VEVTAQLNAD 101 VSGLIRSDTQFWVVKPRIDQ SGVTGLGTLL SGSYIAFTPG KSDEAKDVFQ 151 VQDIPPVTAI GQSGLRLNLIGKNDRILNVN SPVLYENFMV GQVESAHFDP 201 SDQSVHYTIF IQSPNDKLIH SASRFWLESGINIETTGSGI KLNSAPLPAL 251 LSGAISFDSP KTKNSKNVKS EDSFTLYDSR SEVANLPDDRSLYYTAFFKQ 301 SVRGLTVGSP VEYKGLNVGV VSDVPYFDRN DSLHLFENGW IPVRIRIEPS351 RLEINADEQS KEHWKQQFQT ALNKGLTATI SSNNLLTGSK MIELNDQPSA 401SPKLRPHTVY AGDTVIATQG GGLDDLQVKL ADLLDKFDKL PLDKTVAELN 451 GSLAELKSTLKSANAALSSI DKLVGKPQTQ NIPNELNQTL KELRTTLQGV 501 SPQSPIYGDV QNTLQSLDKTLKDVQPVINT LKEKPNALIF NSSSKDPIPK 551 GSR* m154/a154 100.0% identity in553 aa overlap        10        20        30        40        50        60 m154.pepMTDNSPPPNGHAQARVRKNNTFLSAVWLVPLIALIAGGWLWVKEIRNRGPVVTLLMDSAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a154MTDNSPPPNGHAQARVRKNNTFLSAVWLVPLIALIAGGWLWVKEIRNRGPVVTLLMDSAE        10        20        30        40        50        60        70        80        90       100       110       120 m154.pepGIEVNNTVIKVLSIDVGRVIRIKLRDDQKGVEVTAQLNADVSGLIRSDTQFWVVKPRIDQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a154GIEVNNTVIKVLSIDVGRVIRIKLRDDQKGVEVTAQLNADVSGLIRSDTQFWVVKPRIDQ        70        80        90       100       110       120       130       140       150       160       170       180 m154.pepSGVTGLGTLLSGSYIAFTPGKSDEAKDVFQVQDIPPVTAIGQSGLRLNLIGKNDRILNVN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a154SGVTGLGTLLSGSYIAFTPGKSDEAKDVFQVQDIPPVTAIGQSGLRLNLIGKNDRILNVN       130       140       150       160       170       180       190       200       210       220       230       240 m154.pepSPVLYENFMVGQVESAHFDPSDQSVHYTIFIQSPNDKLIHSASRFWLESGINIETTGSGI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a154SPVLYENFMVGQVESAHFDPSDQSVHYTIFIQSPNDKLIHSASRFWLESGINIETTGSGI       190       200       210       220       230       240       250       260       270       280       290       300 m154.pepKLNSAPLPALLSGAISFDSPKTKNSKNVKSEDSFTLYDSRSEVANLPDDRSLYYTAFFKQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a154KLNSAPLPALLSGAISFDSPKTKNSKNVKSEDSFTLYDSRSEVANLPDDRSLYYTAFFKQ       250       260       270       280       290       300       310       320       330       340       350       360 m154.pepSVRGLTVGSPVEYKGLNVGVVSDVPYFDRNDSLHLFENGWIPVRIRIEPSRLEINADEQS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a154SVRGLTVGSPVEYKGLNVGVVSDVPYFDRNDSLHLFENGWIPVRIRIEPSRLEINADEQS       310       320       330       340       350       360       370       380       390       400       410       420 m154.pepKEHWKQQFQTALNKGLTATISSNNLLTGSKMIELNDQPSASPKLRPHTVYAGDTVIATQG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a154KEHWKQQFQTALNKGLTATISSNNLLTGSKMIELNDQPSASPKLRPHTVYAGDTVIATQG       370       380       390       400       410       420       430       440       450       460       470       480 m154.pepGGLDDLQVKLADLLDKFDKLPLDKTVAELNGSLAELKSTLKSANAALSSIDKLVGKPQTQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a154GGLDDLQVKLADLLDKFDKLPLDKTVAELNGSLAELKSTLKSANAALSSIDKLVGKPQTQ       430       440       450       460       470       480       490       500       510       520       530       540 m154.pepNIPNELNQTLKELRTTLQGVSPQSPIYGDVQNTLQSLDKTLKDVQPVINTLKEKPNALIF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a154NIPNELNQTLKELRTTLQGVSPQSPIYGDVQNTLQSLDKTLKDVQPVINTLKEKPNALIF       490       500       510       520       530       540        550m154.pep NSSSKDPIPKGSRX |||||||||||||| a154 NSSSKDPIPKGSRX        550The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 637>:

g155.seq 1 atGAAaatcg GtatcCCACG CGAGTCAtta tcCGGCGAAA cccgcgtagc 51ctgcAcgccc gCCACCGTTG CCctgctggg caAactAGGC TTTGAAACCG 101 TTGtcgaAAGCGGTGCAggt TTGGCGGCAA GTTTggaCGA TGCCGCTTAC 151 CAAACAGCAG GCGCAACCGTTGCCGACAAA GCGGCGGTTT GGGCCTGCCC 201 TTTAATTTAT AAGGTCAACG CGCCGTCCGAAGGCGAGCTG CCGCTGCTCA 251 AAGAAGGTCA AACCATCGTC AGCTTCCTGT GGCCGCGCCAAAACGAGGCT 301 TTGGTCGAGG CCTTGCGCGC CAAGAAAGTC AACGCGCTGG CGATGGACAT351 GGTTCCCCGC ATTTCCCGCG CTCAGGCCTT GGACGCTTTG TCTTCAATGG 401CAAACATCAG CGGCTACCGC GCCGTGATTG AAGCCGCCAA CGCCTTCGGC 451 CGTTTCTTCACCGGTCAAAT CACTGCCGCC GGCAAAGTGC CGCCTGCGCA 501 GGTTTTGGTG ATTGGCGCCGGTGTGGCGGG TTTGGCGGCA ATCGGTACGG 551 CAAATTCGCT CGGCGCAGTG GTGCGCGCGTTCGATACCCG CTTGGAAGTG 601 GCGGAACAAA TCGAATCGAT GGGCGGTAAG TTcctGAAACTCGACTTCCT 651 GCAAGAATCG GGCGGCAGCG GAGACGgctA CGCCAAAGTG ATGAGCGACG701 AATTTATCGC CGCCGAAATG AAGCTCTTTG CCGAACAGGC GAAAGAAGTG 751GACATCATCA TCACCACCGC CGCCATTCCG GGCAAACCCG CTCCCAAGCT 801 GATTACCAAAGAAATGGTGG AAAGCATGAA ATCCGGATCC GTCATCGTCG 851 ATTTGGCGGC GACGGGCGGCAACTGCGAAC TCACCCGACC GGGCGAATTG 901 TCCGTAACCG GCAACGGCGT GAAAATCATCGGCTACACCG ACATGGCAAA 951 CCGCCTTGCC GGACAGTCTT CCCAGCTTTA CGCCACCAACTTGGTGAACC 1001 TGACCAAGCT GTTAAGCCCG AACAAAGAcg gcgaAATCAC GCTGGACTTC1051 GAAGacgtGA TTATCCGCAA TATGACCGTT ACCCGcgacg gcgaaATCAC 1101CTTCCCGCCT CCGccgaTTc aggtTTCcgc ccggccgCAG CAAAcgccgt 1151 ctgaAAAagccgcGCCTGCC GCCAagcccg AgccGaaacc tgttCCcctg 1201 tggaAAAaac tcgCGCCCGCCGCcatcgCC GCCGTATTGG tgctgtgGgt 1251 cggCgcggtc gcacccgcag CATTCTTGAACCACTTTATC GTCTTCGTCC 1301 TCGCCTGCGT CATCGGCTAC CATGTCGTTT GgaacgTCAGCCACTCGCTG 1351 CACACACCGC TGAtgtcggt aaccaaCgcc atctccGGCA tcatggtcgt1401 cggCGCGCTG CTGCAAATCG GTCAGGGcaa cggcttcgtT TCgctGCTGT 1451CGTTTGTTGC CATCCTGATT GCCGGCATCA ATATCTTCGG CGGCTTTGCG 1501 GTTACACGGCGTATGCTGAA TATGTTTAAG AAAGGGTAAThis corresponds to the amino acid sequence <SEQ ID 638; ORF 155.ng>:

g155.pep 1 MKIGIPRESL SGETRVACTP ATVALLGKLG FETVVESGAG LAASLDDAAY 51QTAGATVADK AAVWACPLIY KVNAPSEGEL PLLKEGQTIV SFLWPRQNEA 101 LVEALRAKKVNALAMDMVPR ISRAQALDAL SSMANISGYR AVIEAANAFG 151 RFFTGQITAAGKVPPAQVLV IGAGVAGLAA IGTANSLGAV VRAFDTRLEV 201 AEQIESMGGK FLKLDFLQESGGSGDGYAKV MSDEFIAAEM KLFAEQAKEV 251 DIIITTAAIP GKPAPKLITK EMVESMKSGSVIVDLAATGG NCELTRPGEL 301 SVTGNGVKII GYTDMANRLA GQSSQLYATN LVNLTKLLSPNKDGEITLDF 351 EDVIIRNMTV TRDGEITFPP PPIQVSARPQ QTPSEKAAPA AKPEPKPVPL401 WKKLAPAAIA AVLVLWVGAV APAAFLNHFI VFVLACVIGY HVVWNVSHSL 451HTPLMSVTNA ISGIMVVGAL LQIGQGNGFV SLLSFVAILI AGINIFGGFA 501 VTRRMLNMFKKG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 639>:

m155.seq 1 ATGAAAATCG GTATCCCACG CGAGTCATTA TCCGGCGAAA CCCGCGTCGC 51CTGTACGCCC GCCACCGTCG CCCTGCTGGG CAAACTGGGC TTTGAAACCG 101 TTGTCGAAAGCGGTGCAGGT TTGGCGGCAA GTTTGGACGA TGCCGCTTAC 151 CAAACAGCAG GCGCAACCGTTGCCGACAAA GCGGCGGTTT GGGTCTGCCC 201 TTTGATTTAT AAGGTCAACG CGCCGTCCGAACAGGAACTG CCGCTTTTGA 251 ACGAAGGTCA AACCATCGTC AGCTTCCTGT GGCCGCGCCAAAACGAGGCT 301 TTGGTCGAAG CCTTGCGCGC CAAGAAAGTG AACGCGCTGG CGATGGATAT351 GGTGCCCCGC ATTTCGCGCG CGCAGGCTTT GGACGCTTTG TCTTCGATGG 401CAAACATCAG CGGCTACCGC GCCGTAATTG AAGCCGCCAA CGCCTTCGGC 451 CGTTTCTTCACCGGTCAAAT TACCGCCGCC GGCAAAGTGC CGCCCGCGCA 501 GGTTTTGGTG ATTGGTGCAGGTGTGGCAGG TTTGGCGGCG ATCGGTACGG 551 CAAACTCGCT CGGCGCAGTG GTACGCGCGTTCGATACCCG CTTGGAAGTG 601 GCGGAACAAA TCGAATCGAT GGGCGGCAAG TTCCTGAAACTCGACTTCCC 651 ACAAGAATCG GGCGGCAGCG GAGACGGCTA CGCCAAAGTG ATGAGCGACG701 AATTTATCGC AGCCGAGATG AAGCTCTTTG CCGAGCAGGC GAAAGAAGTG 751GACATCATCA TCACCACCGC CGCCATTCCG GGCAAACCCG CGCCCAAGCT 801 GATTACCAAAGAAATGGTGG AAAGCATGAA ATCCGGCTCC GTCATCGTCG 851 ATTTGGCGGC GGCGACGGGCGGCAACTGCG AACTCACCCG CCCGGGCGAA 901 TTGTCCGTAA CCGGCAACGG CGTGAAAATCATCGGCTACA CCGACATGGC 951 AAACCGCCTT GCCGGACAGT CTTCCCAGCT TTACGCCACCAACTTGGTCA 1001 ACCTGACCAA GCTGTTAAGC CCGAACAAAG ACGGCGAAAT CACGTTGGAC1051 TTCGAAGACG TGATTATCCG CAACATGACC GTTACCCACG ACGGCGAAAT 1101CACCTTCCCG CCTCCGCCGA TTCAAGTTTC CGCCCAGCCG CAGCAAACGC 1151 CGTCTGAAAAAGCCGTGCCT GCCGCCAAGC CCGAGCCAAA ACCCGTTCCC 1201 CTGTGGAAAA AACTCGCGCCCGCCGTCATC GCCGCCGTCT TGGTACTGTG 1251 GGTCGGCGCG GTCGCACCCG CAGCATTCCTGAACCACTTT ATCGTGTTCG 1301 TTCTCGCCTG CGTCATCGGC TACTACGTCG TCTGGAACGTCAGCCACTCG 1351 CTGCACACAC CGCTGATGTC GGTAACCAAC GCCATCTCCG GCATCATCGT1401 CGTCGGCGCG CTGCTGCAAA TCGGTCAGGG CAACGGCTTC GTTTCGCTGC 1451TGTCGTTTGT TGCCATCCTG ATTGCCGGCA TCAACATCTT CGGCGGCTTT 1501 GCGGTAACACGGCGTATGCT GAATATGTTT AAGAAAGGGT AAThis corresponds to the amino acid sequence <SEQ ID 640; ORF 155>:

m155.pep 1 MKIGIPRESL SGETRVACTP ATVALLGKLG FETVVESGAG LAASLDDAAY 51QTAGATVADK AAVWVCPLIY KVNAPSEQEL PLLNEGQTIV SFLWPRQNEA 101LVEALRAKKV NALAMDMVPR ISRAQALDAL SSMANISGYR AVIEAANAFG 151RFFTGQITAA GKVPPAQVLV IGAGVAGLAA IGTANSLGAV VRAFDTRLEV 201AEQIESMGGK FLKLDFPQES GGSGDGYAKV MSDEFIAAEM KLFAEQAKEV 251DIIITTAAIP GKPAPKLITK EMVESMKSGS VIVDLAAATG GNCELTRPGE 301LSVTGNGVKI IGYTDMANRL AGQSSQLYAT NLVNLTKLLS PNKDGEITLD 351FEDVIIRNMT VTHDGEITFP PPPIQVSAQP QQTPSEKAVP AAKPEPKPVP 401LWKKLAPAVI AAVLVLWVGA VAPAAFLNHF IVFVLACVIG YYVVWNVSHS 451LHTPLMSVTN AISGIIVVGA LLQIGQGNGF VSLLSFVAIL IAGINIFGGF 501AVTRRMLNMF KKG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 155 shows 97.9% identity over a 513 aa overlap with a predicted ORF(ORF 155.ng) from N. gonorrhoeae:

m155/g155 97.9% identity in 513 aa overlap          10        20        30        40        50        60 m155.pep  MKIGIPRESLSGETRVACTPATVALLGKLGFETVVESGAGLAASLDDAAYQTAGATVADK  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g155  MKIGIPRESLSGETRVACTPATVALLGKLGFETVVESGAGLAASLDDAAYQTAGATVADK          10        20        30        40        50        60          70        80        90       100       110       120 m155.pep  AAVWVCPLIYKVNAPSEQELPLLNEGQIIVSFLWPRQNEALVEALRAKKVNALAMDMVPR  ||||:|||||||||||| |||||:|||||||||||||||||||||||||||||||||||| g155  AAVWACPLIYKVNAPSEGELPLLKEGQTIVSFLWPRQNEALVEALRAKKVNALAMDMVPR          70        80        90       100       110       120         130       140       150       160       170       180 m155.pep  ISRAQALDALSSMANISGYRAVIEAANAFGRFFTGQITAAGKVPPAQVLVIGAGVAGLAA  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g155  ISRAQALDALSSMANISGYRAVIEAANAFGRFFTGQITAAGKVPPAQVLVIGAGVAGLAA         130       140       150       160       170       180         190       200       210       220       230       240 m155.pep  IGTANSLGAVVRAFDTRLEVAEQIESMGGKFLKLDFPQESGGSGDGYAKVMSDEFIAAEM  |||||||||||||||||||||||||||||||||||| ||||||||||||||||||||||| g155  IGTANSLGAVVRAFDTRLEVAEQIESMGGKFLKLDFLQESGGSGDGYAKVMSDEFIAAEM         190       200       210       220       230       240         250       260       270       280       290       300 m155.pep  KLFAEQAKEVDIIITTAAIPGKPAPKLITKEMVESMKSGSVIVDLAAATGGNCELTRPGE  ||||||||||||||||||||||||||||||||||||||||||||||| |||||||||||| g155  KLFAEQAKEVDIIITTAAIPGKPAPKLITKEMVESMKSGSVIVDLAA-TGGNCELTRPGE         250       260       270       280        290         310       320       330       340       350       360 m155.pep  LSVTGNGVKIIGYTDMANRLAGQSSQLYATNLVNLTKLLSPNKDGEITLDFEDVIIRNMT  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g155  LSVTGNGVKIIGYTDMANRLAGQSSQLYATNLVNLTKLLSPNKDGEITLDFEDVIIRNMT300       310       320       330       340       350         370       380       390       400       410       420 m155.pep  VTHDGEITFPPPPIQVSAQPQQTPSEKAVPAAKPEPKPVPLWKKLAPAVIAAVLVLWVGA  ||:|||||||||||||||:|||||||||:|||||||||||||||||||:||||||||||| g155  VTRDGEITFPPPPIQVSARPQQTPSEKAAPAAKPEPKPVPLWKKLAPAAIAAVLVLWVGA360       370       380       390       400       410         430       440       450       460       470       480 m155.pep  VAPAAFLNHFIVFVLACVIGYYVVWNVSHSLHTPLMSVTNAISGIIVVGALLQIGQGNGF  |||||||||||||||||||||:|||||||||||||||||||||||:|||||||||||||| g155  VAPAAFLNHFIVFVLACVIGYHVVWNVSHSLHTPLMSVTNAISGIMVVGALLQIGQGNGF420       430       440       450       460       470         490       500       510 m155.pep  VSLLSFVAILIAGINIFGGFAVTRRMLNMFKKGX  |||||||||||||||||||||||||||||||||| g155  VSLLSFVAILIAGINIFGGFAVTRRMLNMFKKGX 480       490       500       510The following partial DNA sequence was identified in N. meningitidis<SEQ ID 641>:

a155.seq 1 ATGAAAATCG GTATCCCACG TGAGTCATTA TCCGGCGAAA CCCGCGTCGC 51CTGTACGCCC GCCACCGTCG CCCTGCTGGG CAAACTGGGC TTTGAAACCG 101TTGTCGAAAG CGGCGCAGGT TTGGCGGCAA GTTTGGACGA TGCCGCTTAC 151CAAGCAGCAG GCGCAACCGT TGCCGACAAA GCAGCGGTTT GGGCATACCC 201TTTAATTTAT AAGGTTAACG CGCCGTCCGA AGACGAGCTG CCGCTGCTCA 251AAGAAGGACA GACCATCGTC AGCTTCCTGT GGCCGCGCCA AAACGAGGCT 301TTGGTCGAAG CCTTGCGCGC CAAGAAAGTG AACGCGCTGG CAATGGACAT 351GGTGCCCCGC ATTTCGCGCG CGCAGGCTTT GGACGNTTTG TCTTNGATGG 401CAAACATCAG CGGCTACCGC GCCGTGATTG AAGCCGCCAA CGCCTTCGGC 451CGTTTNTTCA CCGGCCAAAT TACTGCCGCA GGCAAAGTGC CGCCCGCGCA 501GGTTTTGGTG ATTGGTGCAG GTGTGGCAGG TTTGGCGGCG ATCGGTACGG 551CAAACTCGCT CGGCGCAGTG GTACGCGTGT TCGATACCCG CCTG.AAGTG 601GCGGAACAAT TAGAATCGAT GGGCGGCAAG TTCCTGAAAC TCGACTTCCC 651GCAAGAATCG GGCGGCAGCG GCGACGGCTA CGCCAAAGTG ATGAGCGACG 701AATTTATCGC CGCCGAGATG AAGCTTTTTG CCGAGCAGGC GAAAGAAGTG 751GACATCATCA TCACCACCGC CGCCATTCCG GGCAAACCCG CGCCCAAGCN 801NNTNANCAAA GAAATGGTCG AAAGCATGAA ACCCGGCTCC GTCATCGTCG 851ATTTGGCGGC GGCGACGGGC GGCAACTGCG AACTCACCAA ACAGGGCGAA 901TTGTTCGTAA CCGGCAACGG CGTGAAAATC ATCGGCTACA CCGACATGGC 951AAACCGCCTT GCCGGACAGT CTTCGCAGCT TTACGCCACC AACTTGGTCA 1001ACCTGACCAA GCTGTTAAGC CCGAACAAAG ACGGCGAAAT CACGCTGGAC 1051TTCGAAGACG TGATTATCCG CAACATGACC GTTACCCGCG ACGGCGAAAT 1101CACCTTCCCG CCTCCGCCGA TTCAAGTTTC CGCCCAACCG CAGCAAACGC 1151CGTCTGAAAA AGCCGCGCCT GCCGCCAAGC CCGAACCGAA ACCCGTTCCC 1201CTGTGGAAAA AACTCGCGCC CGCCNTNATC GCCGCCGTGT TGGTACTGTG 1251GGTCGGCGCG GTCGCACCCG CAGCATTCCT GAACCACTTT ATCGTCTTCG 1301TCCTCGCCTG CGTCATCGGC TACTATGTCG TTTGGAACGT CAGCCACTCG 1351CTGCACACAC CGCTGATGTC GGTGACCAAC GCCATTTCCG GCATCATCGT 1401CGTCGGCGCG CTGCTGCAAA TCGGTCAGGG CAACGGCTTC GTTTCGCTGC 1451TGTCGTTTGT TGCCATCCTG ATTGCCAGCA TCAACATCTT CGGCGGCTTC 1501TTTGTAACGC GGCGGATGCT GAATATGTTT AGGAAAGGGT AAThis corresponds to the amino acid sequence <SEQ ID 642; ORF 155.a>:

a155.pep 1 MKIGIPRESL SGETRVACTP ATVALLGKLG FETVVESGAG LAASLDDAAY 51QAAGATVADK AAVWAYPLIY KVNAPSEDEL PLLKEGQTIV SFLWPRQNEA 101LVEALRAKKV NALAMDMVPR ISRAQALDXL SXMANISGYR AVIEAANAFG 151RXFTGQITAA GKVPPAQVLV IGAGVAGLAA IGTANSLGAV VRVFDTRLXV 201AEQLESMGGK FLKLDFPQES GGSGDGYAKV MSDEFIAAEM KLFAEQAKEV 251DIIITTAAIP GKPAPKXXXK EMVESMKPGS VIVDLAAATG GNCELTKQGE 301LFVTGNGVKI IGYTDMANRL AGQSSQLYAT NLVNLTKLLS PNKDGEITLD 351FEDVIIRNMT VTRDGEITFP PPPIQVSAQP QQTPSEKAAP AAKPEPKPVP 401LWKKLAPAXI AAVLVLWVGA VAPAAFLNHF IVFVLACVIG YYVVWNVSHS 451LHTPLMSVTN AISGIIVVGA LLQIGQGNGF VSLLSFVAIL IASINIFGGF 501FVTRRMLNMF RKG* m155/a155 95.3% identity in 513 aa overlap        10        20        30        40        50        60 m155.pepMKIGIPRESLSGETRVACTPATVALLGKLGFETVVESGAGLAASLDDAAYQTAGATVADK|||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||| a155MKIGIPRESLSGETRVACTPATVALLGKLGFETWESGAGLAASLDDAAYQAAGATVADK        10        20        30       40        50        60        70        80        90       100       110       120 m155.pepAAVWVCPLIYKVNAPSEQELPLLNEGQIIVSFLWPRQNEALVEALRAKKVNALAMDMVPR||||: |||||||||||:|||||:|||||||||||||||||||||||||||||||||||| a155AAVWAYPLIYKVNAPSEDELPLLKEGQTIVSFLWPRQNEALVEALRAKKVNALAMDMVPR        70        80        90       100       110       120       130       140       150       160       170       180 m155.pepISRAQALDALSSMANISGYRAVIEAANAFGRFFTGQITAAGKVPPAQVLVIGAGVAGLAA |||||||| ||||||||||||||||||||| |||||||||||||||||||||||||||| a155ISRAQALDXLSXMANISGYRAVIEAANAFGRXFTGQITAAGKVPPAQVLVIGAGVAGLAA       130       140       150       160       170       180       190       200       210       220       230       240 m155.pepIGTANSLGAVVRAFDTRLEVAEQIESMGGKFLKLDFPQESGGSGDGYAKVMSDEFIAAEM||||||||||||:||||| ||||:|||||||||||||||||||||||||||||||||||| a155IGTANSLGAVVRVFDTRLXVAEQLESMGGKFLKLDFPQESGGSGDGYAKVMSDEFIAAEM       190       200       210       220       230       240       250       260       270       280       290       300 m155.pepKLFAEQAKEVDIIITTAAIPGKPAPKLITKEMVESMKSGSVIVDLAAATGGNCELTRPGE||||||||||||||||||||||||||  :|||||||| ||||||||||||||||||: || a155KLFAEQAKEVDIIITTAAIPGKPAPKXXXKEMVESMKPGSVIVDLAAATGGNCELTKQGE       250       260       270       280       290       300       310       320       330       340       350       360 m155.pepLSVTGNGVKIIGYTDMANRLAGQSSQLYATNLVNLTKLLSPNKDGEITLDFEDVIIRNMT ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a155LFVTGNGVKIIGYTDMANRLAGQSSQLYATNLVNLTKLLSPNKDGEITLDFEDVIIRNMT       310       320       330       340       350       360       370       380       390       400       410       420 m155.pepVTHDGEITFPPPPIQVSAQPQQTPSEKAVPAAKPEPKPVPLWKKLAPAVIAAVLVLWVGA||:|||||||||||||||||||||||||:||||||||||||||||||| ||||||||||| a155VTRDGEITFPPPPIQVSAQPQQTPSEKAAPAAKPEPKPVPLWKKLAPAXIAAVLVLWVGA       370       380       390       400       410       420       430       440       450       460       470       480 m155.pepVAPAAFLNHFIVFVLACVIGYYVVWNVSHSLHTPLMSVTNAISGIIVVGALLQIGQGNGF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a155VAPAAFLNHFIVFVLACVIGYYVVWNVSHSLHIPLMSVINAISGIIVVGALLQIGQGNGF       430       440       450       460       470       480       490       500       510 m155.pepVSLLSFVAILIAGINIFGGFAVTRRMLNMFKKGX ||||||||||||: ||||||| |||||||||: |||a155 VSLLSFVAILIASINIFGGFFVTRRMLNMFRKGX        490       500       510The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 643>:

g156.seq 1 ATGACTTTCG CCTATTGGTG CATTCTGATT GCCTGCCTAT TGCCGCTTTT 51TTGTGCGGCG TATGCCAAAA AAGCGGGCGG ATTCCGGTTT AAAGACAACC 101ACAATCCTCG CGGTTTTCTG GCACATACGC AAGGCGCAGC CGCCCGTGCC 151CACGCCGCGC AGCAAAACGG TTTTGAAGCC TTTGCACCGT TTGCCGCCGC 201CGTTTTGACG GCACACGCAA CCGGCAATGC CGGACAAGCA ACCGTCAACA 251CGCTTGCCGG ATTGTTCATC CTGTTCCGCC TCGCCTTTAT CTGGTGCTAC 301ATCGCAGACA AAGCAGCATT GCGCTCGCTG ATGTGGGCGG GCGGATTTGC 351CTGCACCGTC GGACTGTTTG TCGCGGCTGC TTGAThis corresponds to the amino acid sequence <SEQ ID 644; ORF 156.ng>:

g156.pep 1 MTFAYWCILI ACLLPLFCAA YAKKAGGFRF KDNHNPRGFL AHTQGAAARA 51HAAQQNGFEA FAPFAAAVLT AHATGNAGQA TVNTLAGLFI LFRLAFIWCY 101IADKAALRSL MWAGGFACTV GLFVAAA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 645>:

m156.seq 1 ATGACTTTCG CCTATTGGTG TATTCTGATT GCCTGCCTAT TGCCGCTTTT 51TTGTGCGGCG TATGCCAAAA AAGCGGGCGG ATTCCGGTTT AAAGACAACC 101ACAATCCGCG CGGTTTTCTA GCGCACACGC AAGGCGCAGC CGCCCGTGCC 151CACGCCGCAC AGCAAAACGG TTTTGAAGCC TTTGCACCGT TTGCCGCCGC 201CGTTTTGACG GCACACGCAA CCGGCAATGC GGCGCAATCG ACCATCAACA 251CGCTTGCCTG CCTGTTCATC CTGTTCCGCC TCGCCTTTAT CTGGTGCTAT 301ATCGCCGACA AAGCCGCTAT GCGCTCACTG ATGTGGGCAG GCGGATTTGC 351CTGCACCGTC GGGCTGTTTG TCGCGGCTGC TTGAThis corresponds to the amino acid sequence <SEQ ID 646; ORF 156>:

m156.pep 1 MTFAYWCILI ACLLPLFCAA YAKKAGGFRF KDNHNPRGFL AHTQGAAARA 51HAAQQNGFEA FAPFAAAVLT AHATGNAAQS TINTLACLFI LFRLAFIWCY 101IADKAAMRSL MWAGGFACTV GLFVAAA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m156/g156 96.1% identity in 127 aa overlap        10        20        30        40        50        60 m156.pepMTFAYWCILIACLLPLFCAAYAKKAGGFRFKDNHNPRGFLAHTQGAAARAHAAQQNGFEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g156MTFAYWCILIACLLPLFCAAYAKKAGGFRFKDNHNPRGFLAHTQGAAARAHAAQQNGFEA        10        20        30        40        50        60        70        80        90       100       110       120 m156.pepFAPFAAAVLTAHATGNAAQSTINTLACLFILFRLAFIWCYIADKAAMRSLMWAGGFACTV|||||||||||||||||:|:|:|||| |||||||||||||||||||:||||||||||||| g156FAPFAAAVLTAHATGNAGQATVNTLAGLFILFRLAFIWCYIADKAALRSLMWAGGFACTV        70        80        90       100       110       120 m156.pepGLFVAAAX |||||||| 8156 GLFVAAAXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 647>:

a156.seq 1 ATGACTTTCG CCTATTGGTG TATTCTGATT GCCTACCTAT TGCCGCTTTT 51TTGTGCGGCG TATGCCAAAA AAGCGGGCGG ATTCCGGTTT AAAGACAACC 101ACAATCCGCG CGATTTTCTG GCGCGCACGC AAGGCACAGC CGCCCGTGCC 151CACGCCGCGC AGCAAAACGG TTTTGAAGCC TTTGCACCGT TTGCAGCCGC 201CGTTTTGACG GCACACGCAA CCGGCAATGC CGGACAAGCA ACCGTCAACA 251CGCTTGCCGG CCTGTTCATC CTGTTCCGCC TCGCCTTTAT CTGGTGCTAC 301ATCGCAGACA AAGCAGCATT ACGCTCGCTG ATGTGGGTGG GCGGATTTGT 351CTGCACCGTC GGGCTGTTTG TCGTGGCTGC TTGAThis corresponds to the amino acid sequence <SEQ ID 648; ORF 156.a>:

a156.pep 1 MTFAYWCILI AYLLPLFCAA YAKKAGGFRF KDNHNPRDFL ARTQGTAARA 51HAAQQNGFEA FAPFAAAVLT AHATGNAGQA TVNTLAGLFI LFRLAFIWCY 101IADKAALRSL MWVGGFVCTV GLFVVAA* m156/a15690.6% identity in 127 aa overlap        10        20        30        40        50        60 m156.pepMTFAYWCILIACLLPLFCAAYAKKAGGFRFKDNHNPRGFLAHTQGAAARAHAAQQNGFEA |||||||||||||||||||||||||||||||||||| |||:|||:|||||||||||||| a156MTFAYWCILIAYLLPLFCAAYAKKAGGFRFKDNHNPRDFLARTQGTAARAHAAQQNGFEA        10        20        30        40        50        60        70        80        90       100       110       120 m156.pepFAPFAAAVLTAHATGNAAQSTINTLACLFILFRLAFIWCYIADKAAMRSLMWAGGFACTV|||||||||||||||||:|:|:|||| |||||||||||||||||||:|||||:|||:||| a156FAPFAAAVLTAHATGNAGQATVNTLAGLFILFRLAFIWCYIADKAALRSLMWVGGFVCTV        70        80        90       100       110       120 m156.pepGLFVAAAX ||||:||| a156 GLFVVAAXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 649>:

g157.seq 1 atgaggaacg aggAAAAACg cgccctgcgc cgcgaattgC gCgGgcggcg 51ttcgcAAATg GGgcgagacg tGCGggCGGC GGCGgCgatA Aaaatcaacc 101gcctgctcaa aCGTtatatc AAGCGCggtc gGaAaatcgG CGTGTATTgg 151cCGATGGGCA AGGAATTGcg TTTGGGCGgc tTtgtcCGCG CGGCGCAAAA 201ACGCgGCGCA AAactctatc tgccttATAT CGAACCGCAC ACGCGGCGGA 251TGTGGTTTAC GCCGTATCCT GAACGCGGAA TGGAACGGGA ACGCAAGCGC 301GGTAGGGCGA AGCTGCATGT CCCTCAGTTT GCAGGGCGCA AAATCCGCGT 351GCACGGTTTG TCGGTATTGC TCGTCCCGCT TGTCGGCATA GACCGCGAAG 401GCTACCGTTT GGGGCAGGCA GGCGGCTATT ACGATGCGAC GCTTTCGGCG 451ATGAAATACC GTTTGCAGGC GAAAACCGTG GGCGTGGGCT TTGCCTGCCA 501GTTGGTGGAC AGGCTCCCAC GCGAGGCGCA CGACCTGCCG CTGGACGGTT 551TTGTATCGGA AGCGGGGATA TTGTGTTTTT AGThis corresponds to the amino acid sequence <SEQ ID 650; ORF 157.ng>:

g157.pep 1 MRNEEKRALR RELRGRRSQM GRDVRAAAAI KINRLLKRYI KRGRKIGVYW 51PMGKELRLGG FVRAAQKRGA KLYLPYIEPH TRRMWFTPYP ERGMERERKR 101GRAKLHVPQF AGRKIRVHGL SVLLVPLVGI DREGYRLGQA GGYYDATLSA 151MKYRLQAKTV GVGFACQLVD RLPREAHDLP LDGFVSEAGI LCF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 651>:

m157.seq 1 ATGAGGAACG AGGAAAAACG CGCCCTGCGC CGCGAATTGC GCGGGCGGCG 51TTCGCAAATG GGGCGGGACG TGCGGGCGGC GGCAACGGTA AAAATCAACC 101ACCTGCTCAA ACGTTATATT AAAAAAGGGC GGAAAATCGG CGTGTATTGG 151CCGATGGGCA AGGAATTGCG TTTGGACGGC TTTGTCCGCG CGGCGCAAAA 201ACGCGGTGCG GAACTCTACC TGCCTTATAT CGAACCGCGT TCGCGGCGGA 251TGTGGTTTAC GCCGTATCCT GCCGATGGAG TAAAACAAGA ACGCAAGCGC 301GGTAGGGCGA AGCTGCATGT CCCTCAGTTT GCAGGTCGGA AAAAGCGTGT 351GCATGATTTG AACCTCCTGC TTGTGCCAGT GGTCGGTATG GACAGGCTGG 401GCTACCGCTT GGGACAGGCA GGCGGCTATT ACGATGCGAC GCTTTCAGCG 451ATGAAATACC GTTTGCAGGC AAAAACCGTG GGCGTGGGCT TTGCCTGCCA 501GTTGGTGGAC AGGCTGCCGG TCGAGGCGCA CGACCGGTCT TTGGACGGTT 551TTGTGTCGGA GGCGGGGATA TTGTGTTTTT AGThis corresponds to the amino acid sequence <SEQ ID 652; ORF 157>:

m157.pep 1 MRNEEKRALR RELRGRRSQM GRDVRAAATV KINHLLKRYI KKGRKIGVYW 51PMGKELRLDG FVRAAQKRGA ELYLPYIEPR SRRMWFTPYP ADGVKQERKR 101GRAKLHVPQF AGRKKRVHDL NLLLVPVVGM DRLGYRLGQA GGYYDATLSA 151MKYRLQAKTV GVGFACQLVD RLPVEAHDRS LDGFVSEAGI LCF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m157/g157 88.1% identity in 193 aa overlap        10        20        30        40        50        60 m157.pepMRNEEKRALRRELRGRRSQMGRDVRAAATVKINHLLKRYIKKGRKIGVYWPMGKELRLDG||||||||||||||||||||||||||||: :|||:|||||||:||||||||||||||| | g157MRNEEKRALRRELRGRRSQMGRDVRAAAAIKINRLLKRYIKRGRKIGVYWPMGKELRLGG        10        20        30        40        50        60        70        80        90       100       110       120 m157.pepFVRAAQKRGAELYLPYIEPRSRRMWFTPYPADGVKQERKRGRAKLHVPQFAGRKKRVHDL||||||||||:|||||||||:||||||||| |:::|||||||||||||||||| ||| | g157FVRAAQKRGAKLYLPYIEPHTRRMWFTPYPERGMERERKRGRAKLHVPQFAGRKIRVHGL        70        80        90       100       110       120       130       140       150       160       170       180 m157.pepNLLLVPVVGMDRLGYRLGQAGGYYDATLSAMKYRLQAKTVGVGFACQLVDRLPVEAHDRS::||||:||:|| |||||||||||||||||||||||||||||||||||||||| ||| | g157SVLLVPLVGIDREGYRLGQAGGYYDATLSAMKYRLQAKTVGVGFACQLVDRLPREAHDLP       130       140       150       160       170       180        190m157.pep LDGFVSEAGI LCFX |||||||||||||| g157 LDGFVSEAGI LCFX        190The following partial DNA sequence was identified in N. meningitidis<SEQ ID 653>:

a157.seq 1 ATGAGGAACG AGGAAAAACA CGCCTTGCGC CGAGAGTTGC GCCGCGCCCG 51CGCGCAGATG GGGCATCAAG GGCGGTTGGC GGCGGGGCAA ACGATTAACC 101 GCCTGCTCAAACGTTATATC AAGCGTGGTC GGAAAATCGG CGTGTATTGG 151 CCGATGGGCA AGGAATTGCGTTTGGACGGC TTTGTCCGCG CGGCGCAAAA 201 ACGCGGTGCA AAACTTTATC TGCCTTATATCGAACCGCGT TCGCGGCGGA 251 TGTGGTTTAC GCCGTATCCT GAAAGCGGAA TGGAACGGGAGCGCATACGG 301 GGCAGGGCGA AGTTGAACGT GCCGCAGTTT GCAGGGCGCA AAATCCGCGT351 GCACGGTTTG TCGGTATTGC TCGTCCCGCT TGTCGGCATA GACCGCGAGG 401GCTACCGCTT AGGACAGGCA GGCGGCTATT ACGATGCGAC GCTTGCGGCG 451 ATGAAATACCGTTTGCAGGC AAAAACCGTG GGCGTGGGCT TTGCCTGCCA 501 GTTTGTGGAC AGGCTGCCGCGCGAACCGCA CGATCTGCTG CTGGACGGTT 551 TTGTGTCGGA GGCGGGGATA TTGTGCTTTT AGThis corresponds to the amino acid sequence <SEQ ID 654; ORF 157.a>:

a157.pep 1 MRNEEKHALR RELRRARAQM GHQGRLAAGQ TINRLLKRYI KRGRKIGVYW 51PMGKELRLDG FVRAAQKRGA KLYLPYIEPR SRRMWFTPYP ESGMERERIR 101 GRAKLNVPQFAGRKIRVHGL SVLLVPLVGI DREGYRLGQA GGYYDATLAA 151 MKYRLQAKTV GVGFACQFVDRLPREPHDLL LDGFVSEAGI LCF* m157/a157 82.4% identity in 193 aa overlap        10        20        30        40        50        60 m157.pepMRNEEKRALRRELRGRRSQMGRDVRAAATVKINHLLKRYIKKGRKIGVYWPMGKELRLDG||||||:|||||||  |:|||::| ||   ||:|||||||:|||||||||||||||||| a157MRNEEKHALRRELRRARAQMGHQGRLAAGQTINRLLKRYIKRGRKIGVYWPMGKELRLDG        10        20        30        40        50        60        70        80        90       100       110       120 m157.pepFVRAAQKRGAELYLPYIEPRSRRMWFTPYPADGVKQERKRGRAKLHVPQFAGRKKRVHDL||||||||||:||||||||||||||||||| :|:::|| ||||||:|||||||| ||| | a157FVRAAQKRGAKLYLPYIEPRSRRMWFTPYPESGMERERIRGRAKLNVPQFAGRKIRVHGL        70        80        90       100       110       120       130       140       150       160       170       180 m157.pepNLLLVPVVGMDRLGYRLGQAGGYYDATLSAMKYRLQAKTVGVGFACQLVDRLPVEAHDRS::||||:||:|| |||||||||||||||:||||||||||||||||||:||||| | || a157SVLLVPLVGIDREGYRLGQAGGYYDATLAAMKYRLQAKTVGVGFACQFVDRLPREPHDLL       130       140       150       160       170       180        190m157.pep LDGFVSEAGI LCFX |||||||||||||| a157 LDGFVSEAGI LCFX        190The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 655>:

g158.seq 1 ATGAAAACCA ATTCAGAAGA ACTGACCGTA TTTGTTCAAG TGGTGGAAAG 51CGGCAGCTTC AGCCGTGCGG CGgagcAGTT GGAGAtggCA AATTCTGCCG 101 TAAGCCGCATCGTCAAACGG CTGGAGGAAA AGTTGGGCGT GAAcCTGCtc 151 aACCGCACCA CGCGGCAACTCAATCTGACG GAAGAAGGCG CGCAATATTT 201 CCGCCGCGCG CAGAGAATCC TGCAAGAAATGGCAGCGGCG GAAACCGAAA 251 TGCTGGCAGT GCACGAAGTA CCGCAAGGCG TGTTGCGCGTGGATTCCGCG 301 ATGCcgatgg TGCTGCATCT GCTGGCGCCG CTGGCAGCAA AATTCAACGA351 ACGCTATCCG CATATCcgaC TTTCGCTCGT TTCTTCCGAa ggctatatca 401atctGattGA Acgcaaagtc gAtatTGCCT TACGGGCCGG AGAATTGGAC 451 GATTCCGGGCTGCGTGCACG CCATCTGTTT GACAGCCACT TCCGCGtagt 501 cgCCAGTCCT GAATATTTAGCAAAACACGG CACGCCACAA TCTGCAGAAG 551 atcTTGCCAA CCATCAATGT TTAGGCTTCACAGAACCCGG TTCTCTAAAT 601 ACATGGGCGG TTTTAGAtgC GCAGGGAAAT CCCTATAAAATTTCACCGCA 651 CTTTACCGCC AGCAGCGGTG AAATCTTACG CTCGTTGTGC CTTTCAAGtt701 gCGGTATTGC TTGCTTATCA GATTTTTTGG TTGACAACGA CATCACTGAA 751GGAAAGTTAA TTCCcctatt cgCCGAACAA ACCTCCAATA AAACACACCC 801 CTTTAATGCTGTTTATTACA GCGATAAAGC CGTCAACCTC CGCTTACGCG 851 TATTTTTGGA TTTTTTAGTGAAGGAACTGG GAAAAAATAT GAATAGAACG 901 AATACCAAAT AAThis corresponds to the amino acid sequence <SEQ ID 656; ORF 158.ng>:

g158.pep 1 MKTNSEELTV FVQVVESGSF SRAAEQLEMA NSAVSRIVKR LEEKLGVNLL 51NRTTRQLNLT EEGAQYFRRA QRILQEMAAA ETEMLAVHEV PQGVLRVDSA 101 MPMVLHLLAPLAAKFNERYP HIRLSLVSSE GYINLIERKV DIALRAGELD 151 DSGLRARHLF DSHFRVVASPEYLAKHGTPQ SAEDLANHQC LGFTEPGSLN 201 TWAVLDAQGN PYKISPHFTASSGEILRSLC LSSCGIACLS DFLVDNDITE 251 GKLIPLFAEQ TSNKTHPFNA VYYSDKAVNLRLRVFLDFLV KELGKNMNRT 301 NTK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 657>:

m158.seq 1 ATGAAAACCA ATTCAGAAGA ACTGACCGTA TTTGTTCAAG TGGTGGAAAG 51CGGCAGCTTC AGCCGTGCGG CGGAGCAGTT GGCGATGGCA AATTCTGCCG 101 TAAGCCGCATCGTCAAACGG CTGGAGGAAA AGTTGGGTGT GAACCTGCTC 151 AACCGCACCA CGCGGCAACTCAGTCTGACG GAAGAAGGCG CGCAATATTT 201 CCGCCGCGCG CAGAGAATCC TGCAAGAAATGGCAGCGGCG GAAACCGAAA 251 TGCTGGCAGT GCACGAAATA CCGCAAGGCG TGTTGAGCGTGGATTCCGCG 301 ATGCCGATGG TGCTGCATCT GCTGGCGCCG CTGGCAGCAA AATTCAACGA351 ACGCTATCCG CATATCCGAC TTTCGCTCGT TTCTTCCGAA GGCTATATCA 401ATCTGATTGA ACGCAAAGTC GATATTGCCT TACGGGCCGG AGAATTGGAC 451 GATTCCGGGCTGCGTGCACG CCATCTGTTT GACAGCCGCT TCCGCGTAAT 501 CGCCAGTCCT GAATACCTGGCAAAACACGG CACGCCGCAA TCTACAGAAG 551 AGCTTGCCGG CCACCAATGT TTAGGCTTCACCGAACCCGG TTCTCTAAAT 601 ACATGGGCGG TTTTAGATGC GCAGGGAAAT CCCTATAAGATTTCACCGCA 651 CTTTACCGCC AGCAGCGGTG AAATCTTACG CTCGTTGTGC CTTTCAGGTT701 GCGGTATTGT TTGCTTATCA GATTTTTTGG TTGACAACGA CATCGCTGAA 751GGAAAGTTAA TTCCCCTGCT CGCCGAACAA ACCTCCGATA AAACACACCC 801 CTTTAATGCTGTTTATTACA GCGATAAAGC CGTCAATCTC CGCTTACGCG 851 TATTTTTGGA TTTTTTAGTGGAGGAACTGG GAAACAATCT CTGTGGATAAThis corresponds to the amino acid sequence <SEQ ID 658; ORF 158>:

m158.pep 1 MKTNSEELTV FVQVVESGSF SRAAEQLAMA NSAVSRIVKR LEEKLGVNLL 51NRTTRQLSLT EEGAQYFRRA QRILQEMAAA ETEMLAVHEI PQGVLSVDSA 101 MPMVLHLLAPLAAKFNERYP HIRLSLVSSE GYINLIERKV DIALRAGELD 151 DSGLRARHLF DSRFRVIASPEYLAKHGTPQ STEELAGHQC LGFTEPGSLN 201 TWAVLDAQGN PYKISPHFTASSGEILRSLC LSGCGIVCLS DFLVDNDIAE 251 GKLIPLLAEQ TSDKTHPFNA VYYSDKAVNLRLRVFLDFLV EELGNNLCG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m158/g158 94.3% identity in 297 aa overlap        10        20        30        40        50        60 m158.pepMKTNSEELTVFVQVVESGSFSRAAEQLAMANSAVSRIVKRLEEKLGVNLLNRTTRQLSLT||||||||||||||||||||||||||| |||||||||||||||||||||||||||||:|| g158MKTNSEELTVFVQVVESGSFSRAAEQLEMANSAVSRIVKRLEEKLGVNLLNRTTRQLNLT        10        20        30        40        50        60        70        80        90       100       110       120 m158.pepEEGAQYFRRAQRILQEMAAAETEMLAVHEIPQGVLSVDSAMPMVLHLLAPLAAKFNERYP|||||||||||||||||||||||||||||:||||| |||||||||||||||||||||||| g158EEGAQYFRRAQRILQEMAAAETEMLAVHEVPQGVLRVDSAMPMVLHLLAPLAAKFNERYP        70        80        90       100       110       120       130       140       150       160       170       180 m158.pepHIRLSLVSSEGYINLIERKVDIALRAGELDDSGLRARHLFDSRFRVIASPEYLAKHGTPQ||||||||||||||||||||||||||||||||||||||||||:|||:||||||||||||| g158HIRLSLVSSEGYINLIERKVDIALRAGELDDSGLRARHLFDSHFRVVASPEYLAKHGTPQ       130       140       150       160       170       180       190       200       210       220       230       240 m158.pepSTEELAGHQCLGFTEPGSLNTWAVLDAQGNPYKISPHFTASSGEILRSLCLSGCGIVCLS|:|:||:|||||||||||||||||||||||||||||||||||||||||||||:|||:||| g158SAEDLANHQCLGFTEPGSLNTWAVLDAQGNPYKISPHFTASSGEILRSLCLSSCGIACLS       190       200       210       220       230       240       250       260       270       280       290       300 m158.pepDFLVDNDIAEGKLIPLLAEQTSDKTHPFNAVYYSDKAVNLRLRVFLDFLVEELGNNLCGX||||||||:|||||||:|||||:|||||||||||||||||||||||||||:|||:|: g158DFLVDNDITEGKLIPLFAEQTSNKTHPFNAVYYSDKAVNLRLRVFLDFLVKELGKNMNRT       250       260       270       280       290       300 g158 NTKXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 659>:

a158.seq 1 ATGAAAACCA ATTCAGAAGA ACTGACCGTA TTTGTTCAAG TGGTGGAAAG 51CGGCAGCTTC AGCCGTGCGG CGGAGCAGTT GGCGATGGCA AATTCTGCCG 101 TAAGCCGCATCGTCAAACGG CTGGAGGAAA AGTTGGGTGT GAACCTGCTC 151 AACCGCACCA CGCGGCAACTCAGTCTGACG GAAGAAGGCG CGCAATATTT 201 CCGCCGCGCG CAGAGAATCC TGCAAGAAATGGCAGCGGCG GAAACCGAAA 251 TGCTGGCAGT GCACGAAATA CCGCAAGGCG TGTTGCGCGTGGATTCCGCG 301 ATGCCGATGG TGCTGCATCT GCTGGCGCCG CTGGCAGCAA AATTCAACGA351 ACGCTATCCG CATATCCGAC TTTCGCTCGT TTCTTCCGAA GGCTATATCA 401ATCTGATTGA ACGCAAAGTC GATATTGCCT TACGGGCCGG AGAATTGGAC 451 GATTCCGGGCTGCGTGCACG CCATCTGTTT GACAGCCGCT TCCGCGTAAT 501 CGCCAGTCCT GAATACCTGGCAAAACACGG CACGCCGCAA TCTACAGAAG 551 AGCTTGCCGG CCACCAATGT TTAGGCTTCACCGAACCCGG TTCTCTAAAT 601 ACATGGGCGG TTTTAGATGC GCAGGGAAAT CCCTATAAGATTTCACCGCA 651 CTTTACCGCC AGCAGCGGTG AAATCTTACG CTCGTTGTGC CTTTCAGGTT701 GCGGTATTGC TTGCTTATCA GATTTTTTGG TTGACAACGA CATCGCTGAA 751GGAAAGTTAA TTCCCCTGCT CGCCGAACAA ACCTCCAATA AAACGCACCC 801 CTTTAATGCTGTTTATTACA GCGATAAAGC CGTCAACCTC CGCTTACGCG 851 TATTTTTGGA TTTTTTAGTGGAGGAACTGG GAAACAATCT CTGTGGATAAThis corresponds to the amino acid sequence <SEQ ID 660; ORF 158.a>:

a158.pep 1 MKTNSEELTV FVQVVESGSF SRAAEQLAMA NSAVSRIVKR LEEKLGVNLL 51NRTTRQLSLT EEGAQYFRRA QRILQEMAAA ETEMLAVHEI PQGVLRVDSA 101 MPMVLHLLAPLAAKFNERYP HIRLSLVSSE GYINLIERKV DIALRAGELD 151 DSGLRARHLF DSRFRVIASPEYLAKHGTPQ STEELAGHQC LGFTEPGSLN 201 TWAVLDAQGN PYKISPHFTASSGEILRSLC LSGCGIACLS DFLVDNDIAE 251 GKLIPLLAEQ TSNKTHPFNA VYYSDKAVNLRLRVFLDFLV EELGNNLCG* m158/a158 99.0% identity in 299 aa overlap        10        20        30        40        50        60 m158.pepMKTNSEELTVFVQVVESGSFSRAAEQLAMANSAVSRIVKRLEEKLGVNLLNRTTRQLSLT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a158MKTNSEELTVFVQVVESGSFSRAAEQLAMANSAVSRIVKRLEEKLGVNLLNRTTRQLSLT        10        20        30        40        50        60        70        80        90       100       110       120 m158.pepEEGAQYFRRAQRILQEMAAAETEMLAVHEIPQGVLSVDSAMPMVLHLLAPLAAKFNERYP||||||||||||||||||||||||||||||||||| |||||||||||||||||||||||| a158EEGAQYFRRAQRILQEMAAAETEMLAVHEIPQGVLRVDSAMPMVLHLLAPLAAKFNERYP        70        80        90       100       110       120       130       140       150       160       170       180 m158.pepHIRLSLVSSEGYINLIERKVDIALRAGELDDSGLRARHLFDSRFRVIASPEYLAKHGTPQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a158HIRLSLVSSEGYINLIERKVDIALRAGELDDSGLRARHLFDSRFRVIASPEYLAKHGTPQ       130       140       150       160       170       180       190       200       210       220       230       240 m158.pepSTEELAGHQCLGFTEPGSLNTWAVLDAQGNPYKISPHFTASSGEILRSLCLSGCGIVCLS||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||| a158STEELAGHQCLGFTEPGSLNTWAVLDAQGNPYKISPHFTASSGEILRSLCLSGCGIACLS       190       200       210       220       230       240       250       260       270       280       290       300 m158.pepDFLVDNDIAEGKLIPLLAEQTSDKTHPFNAVYYSDKAVNLRLRVFLDFLVEELGNNLCGX||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||| a158DFLVDNDIAEGKLIPLLAEQTSNKTHPFNAVYYSDKAVNLRLRVFLDFLVEELGNNLCGX       250       260       270       280       290       300The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 661>:

g160.seq 1 ATGGAcattc tgGACAAact ggtcgatCTC GCccaATTGA CGGGCAGTGC 51GGATGTGCAG TgcctTTTGG GCGGACAATG gcATGaaacc TTGCAACGCG 101 AAGGGCTGGTACACATTGTT ACGGCGGGCA GCGGTTATCT CTGCATCGAC 151 GGCGAAACTT CCCCGCGTCCGGTCGGCACG GGCGATATTG TATTTTTCCC 201 GCGCGGCTTG GGTCATGTGT TGAGCCACGACGGAAAATAC GGAGAAAGTT 251 TACAACCGGA CATACGACAA AACGGCACAT TTATGGTCAAACAGTGCGGC 301 AACGGGCTGG ATATGAGCCT GTTTTGCGCC CGTTTCCGCT ACGACACCCA351 CGCCGATTTG ATGAACGGGC TGCCGGAAAC CGTTTTTCTG AACATTGCCC 401ATCCAAGTTT GCAGTATGTG GTTTCAATGC TGCAACTGGA AAGCGAAAAA 451 CCTTTGACGGGGACGGTTTC CGTGGTCAAC GCATTACCGT CCGTCCTGCT 501 GGTGCTTATC CTGCGCGCCTATCTCGAACA GGATAAGGAT GTCGAACTCT 551 CGGGCGTATT GAAAGGTTGG CAGGACAAACGTTTGGGACA TTTGATCCAA 601 AAGGTGATAG ACAAACCGGA AGACGAATGG AATATTGACAAAATGGTTGC 651 CGCCGCCAAT ATGTCGCGCG CGCAACTGAT GCGCCGCTTC AAAAGCCAAG701 TCGGACTCAG CCCGCACGCC TTTGTGAACC ATATCCGCCT GCAAAAAGGC 751GCATTGCTGC TGAAGAAAAC CCCGGATTCG GTTTTGGAGG TCGCGCTGTC 801 GGTGGGCTTTCAGTCGGAAA CGCATTTCGG CAAGGCGTTC AAACGGCAAT 851 ATCACGTTTC GCCGGGGCAATACCGGAAAG AAGGCGGGCA AAAATAAThis corresponds to the amino acid sequence <SEQ ID 662; ORF 160.ng>:

g160.pep 1 MDILDKLVDL AQLTGSADVQ CLLGGQWHET LQREGLVHIV TAGSGYLCID 51GETSPRPVGT GDIVFFPRGL GHVLSHDGKY GESLQPDIRQ NGTFMVKQCG 101 NGLDMSLFCARFRYDTHADL MNGLPETVFL NIAHPSLQYV VSMLQLESEK 151PLTGTVSVVN ALPSVLLVLI LRAYLEQDKD VELSGVLKGW QDKRLGHLIQ 201 KVIDKPEDEWNIDKMVAAAN MSRAQLMRRF KSQVGLSPHA FVNHIRLQKG 251 ALLLKKTPDS VLEVALSVGFQSETHFGKAF KRQYHVSPGQ YRKEGGQK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 663>:

m160.seq 1 ATGGACATTC TGGACAAACT GGTCGATTTC GCCCAATTGA CGGGCAGTGT 51GGATGTGCAG TGCCTTTTGG GCGGACAATG GTCGGTACGG CATGAAACCT 101 TGCAACGCGAAGGATTGGTA CACATTGTTA CATCGGGCAG CGGCTATCTC 151 TGCATCGACG GCGAAACTTCCCCGCGTCCG GTCAGTACAG GGGATATTGT 201 ATTTTTCCCG CGCGGCTTGG GTCATGTGTTGAGCCACGAC GGAAAATGCG 251 GAGAAAGTTT ACAACCGGAT ATGCGGCAGC ACGGTGCGTTTACGGTCAAG 301 CAGTGCGGCA ACGGACAGGA TATGAGCCTG TTTTGCGCCC GTTTCCGCTA351 CGACACCCAC GCCGATTTGA TGAACGGGCT GCCTGAAACC GTTTTTCTGA 401ACATTGCCCA TCCGAGTTTA CAGTATGTGG TTTCAATGCT GCAACTGGAA 451 AGCAAAAAACCTTTGACGGG GACGGTTTCC ATGGTCAACG CATTGTCGTC 501 CGTCCTGCTG GTGCTTATCCTGCGCGCCTA TCTCGAACAG GATAAGGATG 551 TCGAACTCTC GGGCGTATTG AAAGGTTGGCAGGACAAACG TTTGGGACAT 601 TTAATCCAAA AGGTGATAGA CAAACCGGAA GACGAATGGAATGTCGACAA 651 AATGGTGGCG GCTGCCAATA TGTCGCGCGC GCAACTGATG CGCCGTTTCA701 AAAGCCGGGT CGGACTCAGC CCGCACGCCT TTGTGAACCA TATCCGCCTG 751CAAAAAGGCG CGTTGCTGCT GAAAAAAAAC CCGGATTCGG TTTTGTCGGT 801 CGCACTGTCGGTAGGCTTTC AGTCGGAAAC GCACTTCGGC AAGGCGTTCA 851 AACGGCAATA TCACGTTTCGCCGGGTCAAT ACCGGAAAGA AggCGGGCAA 901 AAATAAThis corresponds to the amino acid sequence <SEQ ID 664; ORF 160>:

m160.pep 1 MDILDKLVDF AQLTGSVDVQ CLLGGQWSVR HETLQREGLV HIVTSGSGYL 51CIDGETSPRP VSTGDIVFFP RGLGHVLSHD GKCGESLQPD MRQHGAFTVK 101 QCGNGQDMSLFCARFRYDTH ADLMNGLPET VFLNIAHPSL QYVVSMLQLE 151SKKPLTGTVS MVNALSSVLL VLILRAYLEQ DKDVELSGVL KGWQDKRLGH 201 LIQKVIDKPEDEWNVDKMVA AANMSRAQLM RRFKSRVGLS PHAFVNHIRL 251 QKGALLLKKN PDSVLSVALSVGFQSETHFG KAFKRQYHVS PGQYRKEGGQ 301 K*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m160/g160 93.4% identity in 301 aa overlap        10        20        30        40        50        60 m160.pepMDILDKLVDFAQLTGSVDVQCLLGGQWSVRHETLQREGLVHIVTSGSGYLCIDGETSPRP|||||||||:||||||:||||||||||   ||||||||||||||:||||||||||||||| g160MDILDKLVDLAQLTGSADVQCLLGGQW---HETLQREGLVHIVTAGSGYLCIDGETSPRP        10        20           30        40        50        70        80        90       100       110       120 m160.pepVSTGDIVFFPRGLGHVLSHDGKCGESLQPDMRQHGAFTVKQCGNGQDMSLFCARFRYDTH|:|||||||||||||||||||| |||||||:||:|:| ||||||| |||||||||||||| g160VGTGDIVFFPRGLGHVLSHDGKYGESLQPDIRQNGTFMVKQCGNGLDMSLFCARFRYDTH 60        70        80        90       100       110       130       140       150       160       170       180 m160.pepADLMNGLPETVFLNIAHPSLQYVVSMLQLESKKPLTGTVSMVNALSSVLLVLILRAYLEQ|||||||||||||||||||||||||||||||:||||||||:|||| |||||||||||||| g160ADLMNGLPETVFLNIAHPSLQYVVSMLQLESEKPLTGTVSVVNALPSVLLVLILRAYLEQ120       130       140       150       160       170       190       200       210       220       230       240 m160.pepDKDVELSGVLKGWQDKRLGHLIQKVIDKPEDEWNVDKMVAAANMSRAQLMRRFKSRVGLS||||||||||||||||||||||||||||||||||:||||||||||||||||||||:|||| g160DKDVELSGVLKGWQDKRLGHLIQKVIDKPEDEWNIDKMVAAANMSRAQLMRRFKSQVGLS180       190       200       210       220       230       250       260       270       280       290       300 m160.pepPHAFVNHIRLQKGALLLKKNPDSVLSVALSVGFQSETHFGKAFKRQYHVSPGQYRKEGGQ|||||||||||||||||||:||||| |||||||||||||||||||||||||||||||||| g160PHAFVNHIRLQKGALLLKKTPDSVLEVALSVGFQSETHFGKAFKRQYHVSPGQYRKEGGQ240       250       260       270       280       290 m160.pep KX ||g160 KXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 665>:

a160.seq 1 ATGGACATTC TGGACAAACT GGTCGATTTC GCCCAATTGA CGGGCAGTGT 51GGATGTGCAG TGCCTTTTGG GCGGACAATG GTCGGTACGG CATGAAACCT 101TGCAACGCGA AGGATTGGTA CACATTGTTA CATCGGGCAG CGGCTATCTC 151TGCATCGACG GCGAAACTTC CCCGCGTCCG GTCAGTACAG GGGATATTGT 201ATTTTTCCCG CGCGGCTTGG GTCATGTGTT GAGCCACGAC GGAAAATGCG 251GAGAAAGTTT ACAACCGGAT ATGCGGCAGC ACGGTGCGTT TACGGTCAAG 301CAGTGCGGCA ACGGACAGGA TATGAGCCTG TTTTGCGCCC GTTTCCGCTA 351CGACACCCAC GCCGATTTGA TGAACGGGCT GCCTGAAACC GTTTTTCTGA 401ACATTGCCCA TCCGAGTTTA CAGTATGTGG TTTCAATGCT GCAACTGGAA 451AGCAAAAAAC CTTTGACGGG GACGGTTTCC ATGGTCAACG CATTGTCGTC 501CGTCCTGCTG GTGCTTATCC TGCGCGCCTA TCTCGAACAG GATAAGGATG 551TCGAACTCTC GGGCGTATTG AAAGGTTGGC AGGACAAACG TTTGGGACAT 601TTAATCCAAA AGGTGATAGA CAAACCGGAA GACGAATGGA ATGTCGACAA 651AATGGTGGCG GCTGCCAATA TGTCGCGCGC GCAACTGATG CGCCGTTTCA 701AAAGCCGGGT CGGACTCAGC CCGCACGCCT TTGTGAACCA TATCCGCCTG 751CAAAAAGGCG CGTTGCTGCT GAAAAAAAAC CCGGATTCGG TTTTGTCGGT 801CGCACTGTCG GTAGGCTTTC AGTCGGAAAC GCACTTCGGC AAGGCGTTCA 851AACGGCAATA TCACGTTTCG CCGGGTCAAT ACCGGAAAGA AGGCGGGCAA 901 AAATAAThis corresponds to the amino acid sequence <SEQ ID 666; ORF 160.a>:

a160.pep 1 MDILDKLVDF AQLTGSVDVQ CLLGGQWSVR HETLQREGLV HIVTSGSGYL 51CIDGETSPRP VSTGDIVFFP RGLGHVLSHD GKCGESLQPD MRQHGAFTVK 101QCGNGQDMSL FCARFRYDTH ADLMNGLPET VFLNIAHPSL QYVVSMLQLE 151SKKPLTGTVS MVNALSSVLL VLILRAYLEQ DKDVELSGVL KGWQDKRLGH 201LIQKVIDKPE DEWNVDKMVA AANMSRAQLM RRFKSRVGLS PHAFVNHIRL 251QKGALLLKKN PDSVLSVALS VGFQSETHFG KAFKRQYHVS PGQYRKEGGQ 301 K* m160/a160100.0% identity in 301 aa overlap        10        20        30        40        50        60 m160.pepMDILDKLVDFAQLTGSVDVQCLLGGQWSVRHETLQREGLVHIVTSGSGYLCIDGETSPRP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a160MDILDKLVDFAQLTGSVDVQCLLGGQWSVRHETLQREGLVHIVTSGSGYLCIDGETSPRP        10        20        30        40        50        60        70        80        90       100       110       120 m160.pepVSTGDIVFFPRGLGHVLSHDGKCGESLQPDMRQHGAFTVKQCGNGQDMSLFCARFRYDTH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a160VSTGDIVFFPRGLGHVLSHDGKCGESLQPDMRQHGAFTVKQCGNGQDMSLFCARFRYDTH        70        80        90       100       110       120       130       140       150       160       170       180 m160.pepADLMNGLPETVFLNIAHPSLQYVVSMLQLESKKPLTGTVSMVNALSSVLLVLILRAYLEQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a160ADLMNGLPETVFLNIAHPSLQYVVSMLQLESKKPLTGTVSMVNALSSVLLVLILRAYLEQ       130       140       150       160       170       180       190       200       210       220       230       240 m160.pepDKDVELSGVLKGWQDKRLGHLIQKVIDKPEDEWNVDKMVAAANMSRAQLMRRFKSRVGLS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a160DKDVELSGVLKGWQDKRLGHLIQKVIDKPEDEWNVDKMVAAANMSRAQLMRRFKSRVGLS       190       200       210       220       230       240       250       260       270       280       290       300 m160.pepPHAFVNHIRLQKGALLLKKNPDSVLSVALSVGFQSETHFGKAFKRQYHVSPGQYRKEGGQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a160PHAFVNHIRLQKGALLLKKNPDSVLSVALSVGFQSETHFGKAFKRQYHVSPGQYRKEGGQ       250       260       270       280       290       300 m160.pep KX|| a160 KXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 667>:

g161.seq 1 ATGGATACCG CAAAAAAAGA CATTTTAGGA TCGGGCTGGA TGCTGGTGGC 51GGCGGCCTGC TTCACCGTTA TGAACGTATT GATTAAAGAG GCATCGGCAA 101AATTTGCCCT CGGCAGCGGC GAATTGGTCT TTTGGCGCAT GCTGTTTTCA 151ACCGTTACGC TCGGTGCTGC CGCCGTATTG CGGCGCGACA CCTTCCGCAC 201GCCCCATTGG AAAAACCACT TAAACCGCAG TATGGTCGGG ACGGGGGCGA 251TGCTGCTGCT GTTTTACGCG GTAACGCATC TGCCTTTGAC AACCGGCGTT 301ACCCTGAGTT ACACCTCGTC GATTTTTttg GCGGTATTTT CCTTCCTGAT 351TTTGAAAGAA CGGATTTCCG TTTACACGCA GGCGGTGCTG CTCCTTGGTT 401TTGCCGGCGT GGTATTGCTG CTTAATCCCT CGTTCCGCAG CGGTCAGGAA 451CCGGCGGCAC TCGCCGGGCT GGCGGGCGGC GCGATGTCCG GCTGGGCGTA 501TTTGAAAGTG CGCGAACTGT CTTTGGCGGG CGAACCCGGC TGGCGCGTCG 551TGTTTTACCT TTCCGCAACC GGCGTGGCGA TGTCGTCggt ttgggcgacg 601Ctgaccggct ggCACAcccT GTCCTTTcca tcggcagttt ATCtgtCGGG 651CATCGGCGTG tccgcgCtgA TTGCCCAaCT GtcgatgAcg cGCGcctaca 701aaGTCGGCGA CAAATTCACG GTTGCCTCGC tttcctaTAt gaccgtcGTC 751TTTTCCGCCC TGTCTGCCGC ATTTTTTCTg ggcgaagagc ttttctggCA 801GGAAATACTC GGTATGTGCA TCATTATcct CAGCGGCATT TTGAGCAGCA 851TCCGCCCCAT TGCCTTCAAA CAGCGGCTGC AAGCCCTCTT CCGCCAAAGA 901 TAAThis corresponds to the amino acid sequence <SEQ ID 668; ORF 161.ng>:

g161.pep 1 MDTAKKDILG SGWMLVAAAC FTVMNVLIKE ASAKFALGSG ELVFWRMLFS 51TVTLGAAAVL RRDTFRTPHW KNHLNRSMVG TGAMLLLFYA VTHLPLTTGV 101TLSYTSSIFL AVFSFLILKE RISVYTQAVL LLGFAGVVLL LNPSFRSGQE 151PAALAGLAGG AMSGWAYLKV RELSLAGEPG WRVVFYLSAT GVAMSSVWAT 201LTGWHTLSFP SAVYLSGIGV SALIAQLSMT RAYKVGDKFT VASLSYMTVV 251FSALSAAFFL GEELFWQEIL GMCIIILSGI LSSIRPIAFK QRLQALFRQR 301 *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 669>:

m161.seq 1 ATGGATACCG CAAAAAAAGA CATTTTAGGA TCGGGCTGGA TGCTGGTGGC 51GGCGGCCTGC TTTACCATTA TGAACGTATT GATTAAAGAG GCATCGGCAA 101AATTTGCCCT CGGCAGCGGC GAATTGGTCT TTTGGCGCAT GCTGTTTTCA 151ACCGTTGCGC TCGGGGCTGC CGCCGTATTG CGTCGGGACA mCTTCCGCAC 201GCCCCATTGG AAAAACCACT TAAACCGCAG TATGGTCGGG ACGGGGGCGA 251TGCTGCTGCT GTTTTACGCG GTAACGCATC TGCCTTTGGC CACTGGCGTT 301ACCCTGAGTT ACACCTCGTC GATTTTTTTG GCGGTATTTT CCTTCCTGAT 351TTTGAAAGAA CGGATTTCCG TTTACACGCA GGCGGTGCTG CTCCTTGGTT 401TTGCCGGCGT GGTATTGCTG CTTAATCCCT CGTTCCGCAG CGGTCAGGAA 451ACGGCGGCAC TCGCCGGGCT GGCGGGCGGC GCGATGTCCG GCTGGGCGTA 501TTTGAAAGTG CGCGAACTGT CTTTGGCGGG CGAACCCGGC TGGCGCGTCG 551TGTTTTACCT TTCCGTGACA GGTGTGGCGA TGTCGTCGGT TTGGGCGACG 601CTGACCGGCT GGCACACCCT GTCCTTTCCA TCGGCAGTTT ATCTGTCGTG 651CATCGGCGTG TCCGCGCTGA TTGCCCAACT GTCGATGACG CGCGCCTACA 701AAGTCGGCGA CAAATTCACG GTTGCCTCGC TTTCCTATAT GACCGTCGTT 751TTTTCCGCTC TGTCTGCCGC ATTTTTTCTG GGCGAAGAGC TTTTCTGGCA 801GGAAATACTC GGTATGTGCA TCATCATCCT CAGCGGTATT TTGAGCAGCA 851TCCGCCCCAC TGCCTTCAAA CAGCGGCTGC AATCCCTGTT CCGCCAAAGA 901 TAAThis corresponds to the amino acid sequence <SEQ ID 670; ORF 161>:

m161.pep 1 MDTAKKDILG SGWMLVAAAC FTIMNVLIKE ASAKFALGSG ELVFWRMLFS 51TVALGAAAVL RRDXFRTPHW KNHLNRSMVG TGAMLLLFYA VTHLPLATGV 101TLSYTSSIFL AVFSFLILKE RISVYTQAVL LLGFAGVVLL LNPSFRSGQE 151TAALAGLAGG AMSGWAYLKV RELSLAGEPG WRVVFYLSVT GVAMSSVWAT 201LTGWHTLSFP SAVYLSCIGV SALIAQLSMT RAYKVGDKFT VASLSYMTVV 251FSALSAAFFL GEELFWQEIL GMCIIILSGI LSSIRPTAFK QRLQSLFRQR 301 *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m161/g161 97.0% identity in 300 aa overlap        10        20        30        40        50        60 m161.pepMDTAKKDILGSGWMLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVL||||||||||||||||||||||:|||||||||||||||||||||||||||||:||||||| g161MDTAKKDILGSGWMLVAAACFTVMNVLIKEASAKFALGSGELVFWRMLFSTVTLGAAAVL        10        20        30        40        50        60        70        80        90       100       110       120 m161.pepRRDXFRTPHWKNHLNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLILKE|||:||||||||||||||||||||||||||||||||:||||||||||||||||||||||| g161RRDTFRTPHWKNHLNRSMVGTGAMLLLFYAVTHLPLTTGVTLSYTSSIFLAVFSFLILKE        70        80        90       100       110       120       130       140       150       160       170       180 m161.pepRISVYTQAVLLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPG|||||||||||||||||||||||||||||| ||||||||||||||||||||||||||||| g161RISVYTQAVLLLGFAGVVLLLNPSFRSGQEPAALAGLAGGAMSGWAYLKVRELSLAGEPG       130       140       150       160       170       180       190       200       210       220       230       240 m161.pepWRVVFYLSVTGVAMSSVWATLTGWHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFT||||||||:||||||||||||||||||||||||||| ||||||||||||||||||||||| g161WRVVFYLSATGVAMSSVWATLTGWHTLSFPSAVYLSGIGVSALIAQLSMTRAYKVGDKFT       190       200       210       220       230       240       250       260       270       280       290       300 m161.pepVASLSYMTVVFSALSAAFFLGEELFWQEILGMCIIILSGILSSIRPTAFKQRLQSLFRQR|||||||||||||||||||||||||||||||||||||||||||||| |||||||:||||| g161VASLSYMTVVFSALSAAFFLGEELFWQEILGMCIIILSGILSSIRPIAFKQRLQALFRQR       250       260       270       280       290       300 m161.pep X| g161 XThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 671>:

a161.seq 1 ATGGATACCG CAAAAAAAGA CATTTTAGGA TCGGGCTGGA TGCTGGTGGC 51GGCGGCCTGC TTTACCATTA TGAACGTATT GATTAAAGAG GCATCGGCAA 101AATTTGCCCT CGGCAGCGGC GAATTGGTCT TTTGGCGCAT GCTGTTTTCA 151ACCGTTGCGC TCGGGGCTGC CGCCGTATTG CGTCGGGACA CCTTCCGCAC 201GCCCCATTGG AAAAACCACT TAAACCGCAG TATGGTCGGG ACGGGGGCGA 251TGCTGCTGCT GTTTTACGCG GTAACGCATC TGCCTTTGGC CACCGGCGTT 301ACCCTGAGTT ACACCTCGTC GATTTTTTTG GCGGTATTTT CCTTCCTGAT 351TTTGAAAGAA CGGATTTCCG TTTACACGCA GGCGGTGCTG CTCCTTGGTT 401TTGCCGGCGT GGTATTGCTG CTTAATCCCT CGTTCCGCAG CGGTCAGGAA 451ACGGCGGCAC TCGCCGGGCT GGCGGGCGGC GCGATGTCCG GCTGGGCGTA 501TTTGAAAGTG CGCGAACTGT CTTTGGCGGG CGAACCCGGC TGGCGCGTCG 551TGTTTTACCT TTCCGTGACA GGTGTGGCGA TGTCATCGGT TTGGGCGACG 601CTGACCGGCT GGCACACCCT GTCCTTTCCA TCGGCAGTTT ATCTGTCGTG 651CATCGGCGTG TCCGCGCTGA TTGCCCAACT GTCGATGACG CGCGCCTACA 701AAGTCGGCGA CAAATTCACG GTTGCCTCGC TTTCCTATAT GACCGTCGTT 751TTTTCCGCTC TGTCTGCCGC ATTTTTTCTG GCCGAAGAGC TTTTCTGGCA 801GGAAATACTC GGTATGTGCA TCATCATCCT CAGCGGTATT TTGAGCAGCA 851TCCGCCCCAC TGCCTTCAAA CAGCGGCTGC AATCCCTGTT CCGCCAAAGA 901 TAAThis corresponds to the amino acid sequence <SEQ ID 672; ORF 161.a>:

a161.pep 1 MDTAKKDILG SGWMLVAAAC FTIMNVLIKE ASAKFALGSG ELVFWRMLFS 51TVALGAAAVL RRDTFRTPHW KNHLNRSMVG TGAMLLLFYA VTHLPLATGV 101TLSYTSSIFL AVFSFLILKE RISVYTQAVL LLGFAGVVLL LNPSFRSGQE 151TAALAGLAGG AMSGWAYLKV RELSLAGEPG WRVVFYLSVT GVAMSSVWAT 201LTGWHTLSFP SAVYLSCIGV SALIAQLSMT RAYKVGDKFT VASLSYMTVV 251FSALSAAFFL AEELFWQEIL GMCIIILSGI LSSIRPTAFK QRLQSLFRQR 301 * m161/a16199.3% identity in 300 aa overlap        10        20        30        40        50        60 m161.pepMDTAKKDILGSGWMLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a161MDTAKKDILGSGWMLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVL        10        20        30        40        50        60        70        80        90       100       110       120 m161.pepRRDXFRTPHWKNHLNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLILKE|||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||| a161RRDTFRTPHWKNHLNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLILKE        70        80        90       100       110       120       130       140       150       160       170       180 m161.pepRISVYTQAVLLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a161RISVYTQAVLLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPG       130       140       150       160       170       180       190       200       210       220       230       240 m161.pepWRVVFYLSVTGVAMSSVWATLTGWHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a161WRVVFYLSVTGVAMSSVWATLTGWHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFT       190       200       210       220       230       240       250       260       270       280       290       300 m161.pepVASLSYMTVVFSALSAAFFLGEELFWQEILGMCIIILSGILSSIRPTAFKQRLQSLFRQR||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||| a161VASLSYMTVVFSALSAAFFLAEELFWQEILGMCIIILSGILSSIRPTAFKQRLQSLFRQR       250       260       270       280       290       300 m161.pep X| a161 XThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 673>:

g163.seq 1 ATGGTTATTT TGACGACTTT GTTTTTTGTG TGTGTTTTGG TGGTATTGGT 51TTTAACCGTG CCGGATCAGG TGCAGATGTG gctCGACCGG GCAAAAGAAG 101TCATTTTTAC CGAGTTCAGC TGGTTTTATG TTTTAACGTT TTCCATTTTt 151ctgGGTTTtc tgctGATACT CTCGGTCAGC GGTTTGGGAA ACATcagGCT 201AGGACGGGAT GAAGATGTGC CGGAATTCGG CTTCCTGTCG TGGCTGGCGA 251TGCTGTTTGC GGCCGGGATG GGCGTGGGCC TGATGTTTTT CGGCGTGGCA 301GAGCCGTTGA TGCATTATTT TTCGGACATT ACGGTCGGCG CGCCGGAACA 351CAGGCAGCAG CAGGCATTGC TGCACACGGT GTTCCATTGG GGCGTTCACG 401CCTGGTCGGT GTACGGTACG ATTGCATTGG CTTTGGCTTA TTTCGGTTTC 451CGCTACAAAC TGCCGCTTGC CCTGCGTTCT TGTTTTTACC CCCTGTTGAA 501AGAAAAAATT TCCGGAAGGT TCGGCGATGC CATTGATATT ATGGCGTTGC 551TTGCTACTTT TTTCGGCATC ATCACCACAT TGGGGTTCGG GGCTTCGCAA 601CTGGGCGCCG GATTGCAGGA AATGGGCTGG ATTGCCGAAA ACAGCTTCGG 651CGTGCAGGTC TTGATTATCG CCGCCGTAAT GTCCCTCGCC GTCGTTTCGG 701CAATATCCGG CGTGGGGAAG GGCGTGAAGG TGTTGAGCGA GTTGAACCTG 751GGCCTTGCGT TTTTGCTGCT GTTTTTTGTT TTGGCGGCGG ACCCCACTGT 801TTACCTGTTG TCGGCATTCG GCGACAACAT AGGGAACTAC CTCGGAAATC 851TGGTGCGCCT CAGTTTGAAA ACTTATGCGT ACGAACGGGA ACACAAGCCG 901TGGTTTGAAT CTTGGACGGT GCTTTATTGG GCGTGGTGGT GTTCTTGGgc 951gcCGTTTGTG GGTTTGTTTA TCGCGCGCAT TTCAAAGGGg cgcaccatCc 1001gcgagtttgt CTTCGGGGTT TTGCTCATCC CCGGCCTGTT CGGCGTTTTG 1051TGGTTTACCG TCTTCGGCAA TACGGCGATT TGGCTGAATG ACGGGGTTGC 1101GGGGGGAATG CTCGAAAAGA TGACCTCCTC TCCGGAAACG CTGCTTTTTA 1151AATTCTTTAA TTACCTCCCC CTGCCCGAAC TGACGAGCAT CGTCAGCCTG 1201CTGGTCATTT CCCTGTTTTT TGTAACTTCT GCCGACTCCG GGATTTATGT 1251CCTGAACAAT ATTACCTCTC GGGACAAAGG CTTGAGCGCG CCACGGTGGC 1301AGGCGGTTAT GTGGGGCGTG CTGatgtcTG CCGTTGCCGT TTTGCTGATG 1351CGCTCGGGCG GACTCGGCAA CCTGCAGTCT ATGACCCTGA TTGTTTCCCT 1401GCCGTTTGCC CTGCTGATGC TGATAATGTG TTTCAGCCTG TGGAAAGGCT 1451TGAGTGCGGA TAAGAAATAT TTTGAGACCC GGGTCAACCC TACCAGTGTA 1501TTTTGGACGG GCGGCAAGTG GAAAGAACGG CTGGTGCGGA TAATGAGCCA 1551GACGCAGGAG CAGGATATTT TAAAATTCCT CAAACATACC GCATCGCCCG 1601CTATGCACGA GTTGCAACGG GAGCTTTCGG AAGAATACGG CTTGAGCGTC 1651CGGGTCGATA AGATGTTTCA TCAGGACGAG CCCGCAATCG AGTTCGTCAT 1701TCGGAAAGAG ACGATGCGCG ATTTTATGTA CGGGATTAAG TCTGTCGGGC 1751AGGATGTATC CGACCAGTTG ATTAACGACG GCAAGCTGCC GCATATCCGG 1801CACCAGACAA CTTACAAACC CTACGCTTAT TTTTTCGACG GGCGCGTCGG 1851GTACGATGTG CAGTATATGA ACAAGGACGA GCTGATTGCC GACATTTTGA 1901AAAACTACGA ACGTTATTTG ATGTTGTTGG ATGATGTCGG TCAGGAACTG 1951ATGGCGCACG AGCAGGTGGA ATTGGCAGAG TAAThis corresponds to the amino acid sequence <SEQ ID 674; ORF 163.ng>:

g163.pep 1 MVILTTLFFV CVLVVLVLTV PDQVQMWLDR AKEVIFTEFS WFYVLTFSIF 51LGFLLILSVS GLGNIRLGRD EDVPEFGFLS WLAMLFAAGM GVGLMFFGVA 101EPLMHYFSDI TVGAPEHRQQ QALLHTVFHW GVHAWSVYGT IALALAYFGF 151RYKLPLALRS CFYPLLKEKI SGRFGDAIDI MALLATFFGI ITTLGFGASQ 201LGAGLQEMGW IAENSFGVQV LIIAAVMSLA VVSAISGVGK GVKVLSELNL 251GLAFLLLFFV LAADPTVYLL SAFGDNIGNY LGNLVRLSLK TYAYEREHKP 301WFESWTVLYW AWWCSWAPFV GLFIARISKG RTIREFVFGV LLIPGLFGVL 351WFTVFGNTAI WLNDGVAGGM LEKMTSSPET LLFKFFNYLP LPELTSIVSL 401LVISLFFVTS ADSGIYVLNN ITSRDKGLSA PRWQAVMWGV LMSAVAVLLM 451RSGGLGNLQS MTLIVSLPFA LLMLIMCFSL WKGLSADKKY FETRVNPTSV 501FWTGGKWKER LVRIMSQTQE QDILKFLKHT ASPAMHELQR ELSEEYGLSV 551RVDKMFHQDE PAIEFVIRKE TMRDFMYGIK SVGQDVSDQL INDGKLPHIR 601HQTTYKPYAY FFDGRVGYDV QYMNKDELIA DILKNYERYL MLLDDVGQEL 651 MAHEQVELAE *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 675>:

m163.seq 1 ATGGTTATTT TGACGACTTT GTTTTTTGTG TGTGTTTTGG TGGTATTGGT 51TTTAACCGTG CCGGATCAGG TGCAGATGTG GCTCGATCGG GCAAAAGAAG 101TCATTTTTAC CGAGTTCAGC TGGTTTTATG TTTTAACGTT TTCCATTTTT 151CTGGGTTTCC TGCTGATACT CTCGGTCAGC AGTTTGGGAA ACATCAGGCT 201CGGACGGGAT GAAGATGTGC CGGAATTCGG CTTCCTGTCG TGGCTGGCGA 251TGCTGTTTGC GGCCGGGATG GGCGTGGGTC TGATGTTTTT CGGCGTGGCA 301GAGCCGTTGA TGCATTATTT TTCGGACATT ACGGCCGGCA CGCCGGAACA 351CAGGCAGCAG CAGGCATTGC TGCACACGGT GTTCCATTGG GGCGTTCACG 401CTTGGTCGGT GTACGGTACG ATTGCATTGG CTTTGGCTTA TTTCGGTTTC 451CGCTACAAGC TGCCGCTTGC CCTGCGTTCT TGTTTTTACC CCCTGTTGAA 501AGAAAAAATT TCCGGAAGGT TCGGCGATGC CATTGATATT ATGGCGTTGC 551TTGCTACTTT TTTCGGCATC ATCACCACAT TGGGGTTCGG GGCTTCGCAA 601CTGGGCGCCG GATTGCAGGA AATGGGCTGG ATTGCCGAAA ACAGCTTCAG 651CGTGCAGGTT TTGATTATCG CCGCCGTCAT GTCCCTCGCC GTCGTTTCGG 701CAATATCCGG CGTGGGGAAG GGCGTGAAGG TGTTGAGCGA GTTGAACCTG 751GGCCTTGCGT TTTTGCTGCT GTTTTTTGTT TTGGCGGCGG GACCCACTGT 801TTACCTGTTG TCGGCATTCG GCGACAACAT AGGGAACTAC CTCGGAAATC 851TGGTGCGCCT CAGTTTTAAA ACTTATGCGT ACGAACGGGA ACACAAGCCG 901TGGTTTGAAT CTTGGACGGT GCTTTATTGG GCGTGGTGGT GTTCTTGGGC 951GCCGTTTGTG GGTTTGTTTA TCGCGCGCAT TTCAAAGGGG CGCACCATCC 1001GCGAGTTTGT CTTCGGGGTT TTGCTCATCC CCGGCCTGTT CGGCGTTTTG 1051TGGTTTACCG TCTTCGGCAA TACGGCGATT TGGCTGAATG ACGGGGTTGC 1101GGGGGGAATG CTCGAAAAGA TGACCTCCTC TCCGGAAACG CTGCTTTTTA 1151AATTCTTTAA TTACCTCCCC CTGCCCGAAT TGACGAGCAT CGTCAGCCTG 1201CTGGTCATTT CTCTGTTTTT TGTAACTTCT GCCGATTCCG GGATTTATGT 1251CCTGAACAAT ATTACCTCTC GGGACAAAGG CTTGAGCGCG CCACGGTGGC 1301AGGCGGTTAT GTGGGGCGTG CTGATGTCTG CCGTTGCCGT TTTGCTGATG 1351CGCTCGGGCG GACTCGGCAA CCTGCAGTCT ATGACCCTGA TTGTTTCCCT 1401GCCGTTTGCC CTGCTGATGC TGATAATGTG TTTCAGCCTG TGGAAAGGCT 1451TGAGTGCGGA TAAGAAATAT TTTGAGACCC GGGTTAACCC TACCAGTGTA 1501TTTTGGACGG GCGGCAAGTG GAAAGAACGG CTGGTGCAGA TAATGAGCCA 1551GACGCAGGAG CAGGATATTT TAAAATTCCT CAAACAGACT GCATCGCCCG 1601CTATGCACGA GTTGCAACGG GAGCTTTCGG AAGAATACGG CTTGAGCGTC 1651CGGGTCGATA AAATGTTTCA TCGGGACGAG CCCGCAATCG AGTTCGTCAT 1701TCGGAAAGAG ACGATGCGCG ATTTTATGTA CGGGATTAAG TCTGTCGGGC 1751AGGATGTATC CGACCAGTTG ATTAACGACG GCAAGCTGCC GCATATCCGG 1801CATCAGACAA CTTACAAACC CTACGCTTAT TTTTTCGACG GGCGCGTCGG 1851GTACGATGTG CAGTATATGA ACAAGGACGA GCTGATTGCC GACATTTTGA 1901AAAACTACGA ACGTTATTTG ATGTTGTTGG ATGATGTCGG TCAGGAACTG 1951ATGGCGCACG AGCAGGTGGA ATTGGCAGAG TAAThis corresponds to the amino acid sequence <SEQ ID 676; ORF 163>:

m163.pep 1 MVILTTLFFV CVLVVLVLTV PDQVQMWLDR AKEVIFTEFS WFYVLTFSIF 51LGFLLILSVS SLGNIRLGRD EDVPEFGFLS WLAMLFAAGM GVGLMFFGVA 101EPLMHYFSDI TAGTPEHRQQ QALLHTVFHW GVHAWSVYGT IALALAYFGF 151RYKLPLALRS CFYPLLKEKI SGRFGDAIDI MALLATFFGI ITTLGFGASQ 201LGAGLQEMGW IAENSFSVQV LIIAAVMSLA VVSAISGVGK GVKVLSELNL 251GLAFLLLFFV LAAGPTVYLL SAFGDNIGNY LGNLVRLSFK TYAYEREHKP 301WFESWTVLYW AWWCSWAPFV GLFIARISKG RTIREFVFGV LLIPGLFGVL 351WFTVFGNTAI WLNDGVAGGM LEKMTSSPET LLFKFFNYLP LPELTSIVSL 401LVISLFFVTS ADSGIYVLNN ITSRDKGLSA PRWQAVMWGV LMSAVAVLLM 451RSGGLGNLQS MTLIVSLPFA LLMLIMCFSL WKGLSADKKY FETRVNPTSV 501FWTGGKWKER LVQIMSQTQE QDILKFLKQT ASPAMHELQR ELSEEYGLSV 551RVDKMFHRDE PAIEFVIRKE TMRDFMYGIK SVGQDVSDQL INDGKLPHIR 601HQTTYKPYAY FFDGRVGYDV QYMNKDELIA DILKNYERYL MLLDDVGQEL 651 MAHEQVELAE *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m163/g163 98.6% identity in 660 aa overlap        10        20        30        40        50        60 m163.pepMVILTTLFFVCVLVVLVLTVPDQVQMWLDRAKEVIFTEFSWFYVLTFSIFLGFLLILSVS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g163MVILTTLFFVCVLVVLVLTVPDQVQMWLDRAKEVIFTEFSWFYVLTFSIFLGFLLILSVS        10        20        30        40        50        60        70        80        90       100       110       120 m163.pepSLGNIRLGRDEDVPEFGFLSWLAMLFAAGMGVGLMFFGVAEPLMHYFSDITAGTPEHRQQ:||||||||||||||||||||||||||||||||||||||||||||||||||:|:|||||| g163GLGNIRLGRDEDVPEFGFLSWLAMLFAAGMGVGLMFFGVAEPLMHYFSDITVGAPEHRQQ        70        80        90       100       110       120       130       140       150       160       170       180 m163.pepQALLHTVFHWGVHAWSVYGTIALALAYFGFRYKLPLALRSCFYPLLKEKISGRFGDAIDI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g163QALLHTVFHWGVHAWSVYGTIALALAYFGFRYKLPLALRSCFYPLLKEKISGRFGDAIDI       130       140       150       160       170       180       190       200       210       220       230       240 m163.pepMALLATFFGIITTLGFGASQLGAGLQEMGWIAENSFSVQVLIIAAVMSLAVVSAISGVGK||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||| g163MALLATFFGIITTLGFGASQLGAGLQEMGWIAENSFGVQVLIIAAVMSLAVVSAISGVGK       190       200       210       220       230       240       250       260       270       280       290       300 m163.pepGVKVLSELNLGLAFLLLFFVLAAGPTVYLLSAFGDNIGNYLGNLVRLSFKTYAYEREHKP||||||||||||||||||||||| ||||||||||||||||||||||||:||||||||||| g163GVKVLSELNLGLAFLLLFFVLAADPTVYLLSAFGDNIGNYLGNLVRLSLKTYAYEREHKP       250       260       270       280       290       300       310       320       330       340       350       360 m163.pepWFESWTVLYWAWWCSWAPFVGLFIARISKGRTIREFVFGVLLIPGLFGVLWFTVFGNTAI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g163WFESWTVLYWAWWCSWAPFVGLFIARISKGRTIREFVFGVLLIPGLFGVLWFTVFGNTAI       310       320       330       340       350       360       370       380       390       400       410       420 m163.pepWLNDGVAGGMLEKMTSSPETLLFKFFNYLPLPELTSIVSLLVISLFFVTSADSGIYVLNN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g163WLNDGVAGGMLEKMTSSPETLLFKFFNYLPLPELTSIVSLLVISLFFVTSADSGIYVLNN       370       380       390       400       410       420       430       440       450       460       470       480 m163.pepITSRDKGLSAPRWQAVMWGVLMSAVAVLLMRSGGLGNLQSMTLIVSLPFALLMLIMCFSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g163ITSRDKGLSAPRWQAVMWGVLMSAVAVLLMRSGGLGNLQSMTLIVSLPFALLMLIMCFSL       430       440       450       460       470       480       490       500       510       520       530       540 m163.pepWKGLSADKKYFETRVNPTSVFWTGGKWKERLVQIMSQTQEQDILKFLKQTASPAMHELQR||||||||||||||||||||||||||||||||:|||||||||||||||:||||||||||| g163WKGLSADKKYFETRVNPTSVFWTGGKWKERLVRIMSQTQEQDILKFLKHTASPAMHELQR       490       500       510       520       530       540       550       560       570       580       590       600 m163.pepELSEEYGLSVRVDKMFHRDEPAIEFVIRKETMRDFMYGIKSVGQDVSDQLINDGKLPHIR|||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||| g163ELSEEYGLSVRVDKMFHQDEPAIEFVIRKETMRDFMYGIKSVGQDVSDQLINDGKLPHIR       550       560       570       580       590       600       610       620       630       640       650       660 m163.pepHQTTYKPYAYFFDGRVGYDVQYMNKDELIADILKNYERYLMLLDDVGQELMAHEQVELAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g163HQTTYKPYAYFFDGRVGYDVQYMNKDELIADILKNYERYLMLLDDVGQELMAHEQVELAE       610       620       630       640       650       660 m163.pep X| g163 XThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 677>:

a163.seq 1 ATGGTTATTT TGACGACTTT GTTTTTTGTG TGTGTTTTGG TGGTATTGGT 51TTTAACCGTG CCGGATCAGG TGCAGATGTG GCTCGATCGG GCAAAAGAAG 101TCATTTTTAC CGAGTTCAGC TGGTTTTATG TTTTAACGTT TTCCATTTTT 151CTGGGTTTCC TGCTGATACT CTCGGTCAGC AGTTTGGGAA ACATCAGGCT 201CGGACGGGAT GAAGATGTGC CGGAATTCGG CTTCCTGTCG TGGCTGGCGA 251TGCTGTTTGC GGCCGGGATG GGCGTGGGTC TGATGTTTTT CGGCGTGGCA 301GAGCCGTTGA TGCATTATTT TTCGGACATT ACGGCCGGCA CGCCGGAACA 351CAGGCAGCAG CAGGCATTGC TGCACACGGT GTTCCATTGG GGCGTTCACG 401CTTGGTCGGT GTACGGTACG ATTGCATTGG CTTTGGCTTA TTTCGGTTTC 451CGCTACAAGC TGCCGCTTGC CCTGCGTTCT TGTTTTTACC CCCTGTTGAA 501AGAAAAAATT TCCGGAAGGT TCGGCGATGC CATTGATATT ATGGCGTTGC 551TTGCTACTTT TTTCGGCATC ATCACCACAT TGGGGTTCGG GGCTTCGCAA 601CTGGGCGCCG GATTGCAGGA AATAGGCTGG ATTGCCGAAA ACAGCTTCAG 651CGTGCAGGTT TTGATTATCG CCGCCGTCAT GTCCCTCGCC GTCGTTTCGG 701CAATATCCGG CGTGGGGAAG GGTGTGAAGG TGTTGAGCGA GTTGAACCTG 751GGTCTTGCGT TTTTGCTGCT GTTTTTTGTT TTGGCGGCGG GTCCCACTGT 801TTACCTGTTG TCGGCATTCG GCGACAACAT AGGGAACTAC CTCGGAAATC 851TGGTGCGCCT CAGTTTTAAA ACTTATGCGT ACGAACGGGA ACACAAGCCG 901TGGTTTGAAT CTTGGACGGT GCTTTATTGG GCGTGGTGGT GTTCTTGGGC 951GCCGTTTGTG GGTTTGTTTA TCGCGCGCAT TTCAAAGGGG CGCACCATCC 1001GCGAGTTTGT CTTCGGGGTT TTGCTCATCC CCGGCCTGTT CGGCGTTTTG 1051TGGTTTACCG TCTTCGGCAA TACGCCGATT TGGCTGAATG ACGGGGTTGC 1101GGGGGGAGTG CTCGAAAAGA TGACCTCCTC TCCGGAAACG CTGCTTTTTA 1151AATTCTTTAA TTACCTCCCC CTGCCCGAAT TGACGAGCAT CGTCAGCCTG 1201CTGGTCATTT CTCTGTTTTT TGTAACTTCT GCCGATTCCG GGATTTATGT 1251CCTGAACAAT ATTACCTCTC GGGACAAAGG CTTGAGCGCG CCACGGTGGC 1301AGGCGGTTAT GTGGGGCGTG CTGATGTCTG CCGTTGCCGT TTTGCTGATG 1351CGCTCGGGCG GACTCGGCAA CCTGCAGTCT ATGACCCTGA TTGTTTCCCT 1401GCCGTTTGCC CTGCTGATGC TGATAATGTG TTTCAGCCTG TGGAAAGGAT 1451TGAGTGCGGA TAAGAAATAT TTTGAGACCC GGGTTAACCC TACCAGTGTA 1501TTTTGGACGG GCGGCAAGTG GAAAGAACGG CTGGTGCAGA TAATGAGCCA 1551GACGCAGGAG CAGGATATTT TAAAATTCCT CAAACATACC GCATCGCCCG 1601CTATGCACGA GTTACAACGG GAGCTTTCGG AAGAATACGG CTTGAGCGTC 1651CGGGTCGATA AGATGTTTCA TCAGGACGAG CCCGCAATCG AGTTCGTCAT 1701TCGGAAAGAG ACGATGCGCG ATTTTATGTA CGGGATTAAG TCTGTCGGGC 1751AGGATGTATC CGACCAGTTG ATTAACGACG GCAAGCTGCC GCATATCCGG 1801CATCAGACAA CTTACAAACC CTACGCTTAT TTTTTCGACG GGCGCGTCGG 1851GTACGATGTG CAGTATATGA ACAAGGACGA GCTGATTGCC GACATTTTGA 1901AAAACTACGA ACGTTATTTG ATGTTGTTGG ATGATGTCGG TCAGGAACTG 1951ATGGCGCACG AGCAGGTGGA ATTGGCAGAG TAAThis corresponds to the amino acid sequence <SEQ ID 678; ORF 163.a>:

a163.pep 1 MVILTTLFFV CVLVVLVLTV PDQVQMWLDR AKEVIFTEFS WFYVLTFSIF 51LGFLLILSVS SLGNIRLGRD EDVPEFGFLS WLAMLFAAGM GVGLMFFGVA 101EPLMHYFSDI TAGTPEHRQQ QALLHTVFHW GVHAWSVYGT IALALAYFGF 151RYKLPLALRS CFYPLLKEKI SGRFGDAIDI MALLATFFGI ITTLGFGASQ 201LGAGLQEIGW IAENSFSVQV LIIAAVMSLA VVSAISGVGK GVKVLSELNL 251GLAFLLLFFV LAAGPTVYLL SAFGDNIGNY LGNLVRLSFK TYAYEREHKP 301WFESWTVLYW AWWCSWAPFV GLFIARISKG RTIREFVFGV LLIPGLFGVL 351WFTVFGNTAI WLNDGVAGGV LEKMTSSPET LLFKFFNYLP LPELTSIVSL 401LVISLFFVTS ADSGIYVLNN ITSRDKGLSA PRWQAVMWGV LMSAVAVLLM 451RSGGLGNLQS MTLIVSLPFA LLMLIMCFSL WKGLSADKKY FETRVNPTSV 501FWTGGKWKER LVQIMSQTQE QDILKFLKHT ASPAMHELQR ELSEEYGLSV 551RVDKMFHQDE PAIEFVIRKE TMRDFMYGIK SVGQDVSDQL INDGKLPHIR 601HQTTYKPYAY FFDGRVGYDV QYMNKDELIA DILKNYERYL MLLDDVGQEL 651 MAHEQVELAE *m163/a163 99.4% identity in 660 aa overlap        10        20        30        40        50        60 m163.pepMVILTTLFFVCVLVVLVLTVPDQVQMWLDRAKEVIFTEFSWFYVLTFSIFLGFLLILSVS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a163MVILTTLFFVCVLVVLVLTVPDQVQMWLDRAKEVIFTEFSWFYVLTFSIFLGFLLILSVS        10        20        30        40        50        60        70        80        90       100       110       120 m163.pepSLGNIRLGRDEDVPEFGFLSWLAMLFAAGMGVGLMFFGVAEPLMHYFSDITAGTPEHRQQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a163SLGNIRLGRDEDVPEFGFLSWLAMLFAAGMGVGLMFFGVAEPLMHYFSDITAGTPEHRQQ        70        80        90       100       110       120       130       140       150       160       170       180 m163.pepQALLHTVFHWGVHAWSVYGTIALALAYFGFRYKLPLALRSCFYPLLKEKISGRFGDAIDI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a163QALLHTVFHWGVHAWSVYGTIALALAYFGFRYKLPLALRSCFYPLLKEKISGRFGDAIDI       130       140       150       160       170       180       190       200       210       220       230       240 m163.pepMALLATFFGIITTLGFGASQLGAGLQEMGWIAENSFSVQVLIIAAVMSLAVVSAISGVGK|||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||| a163MALLATFFGIITTLGFGASQLGAGLQEIGWIAENSFSVQVLIIAAVMSLAVVSAISGVGK       190       200       210       220       230       240       250       260       270       280       290       300 m163.pepGVKVLSELNLGLAFLLLFFVLAAGPTVYLLSAFGDNIGNYLGNLVRLSFKTYAYEREHKP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a163GVKVLSELNLGLAFLLLFFVLAAGPTVYLLSAFGDNIGNYLGNLVRLSFKTYAYEREHKP       250       260       270       280       290       300       310       320       330       340       350       360 m163.pepWFESWTVLYWAWWCSWAPFVGLFIARISKGRTIREFVFGVLLIPGLFGVLWFTVFGNTAI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a163WFESWTVLYWAWWCSWAPFVGLFIARISKGRTIREFVFGVLLIPGLFGVLWFTVFGNTAI       310       320       330       340       350       360       370       380       390       400       410       420 m163.pepWLNDGVAGGMLEKMTSSPETLLFKFFNYLPLPELTSIVSLLVISLFFVTSADSGIYVLNN|||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||| a163WLNDGVAGGVLEKMTSSPETLLFKFFNYLPLPELTSIVSLLVISLFFVTSADSGIYVLNN       370       380       390       400       410       420       430       440       450       460       470       480 m163.pepITSRDKGLSAPRWQAVMWGVLMSAVAVLLMRSGGLGNLQSMTLIVSLPFALLMLIMCFSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a163ITSRDKGLSAPRWQAVMWGVLMSAVAVLLMRSGGLGNLQSMTLIVSLPFALLMLIMCFSL       430       440       450       460       470       480       490       500       510       520       530       540 m163.pepWKGLSADKKYFETRVNPTSVFWTGGKWKERLVQIMSQTQEQDILKFLKQTASPAMHELQR||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||| a163WKGLSADKKYFETRVNPTSVFWTGGKWKERLVQIMSQTQEQDILKFLKHTASPAMHELQR       490       500       510       520       530       540       550       560       570       580       590       600 m163.pepELSEEYGLSVRVDKMFHRDEPAIEFVIRKETMRDFMYGIKSVGQDVSDQLINDGKLPHIR|||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||| a163ELSEEYGLSVRVDKMFHQDEPAIEFVIRKETMRDFMYGIKSVGQDVSDQLINDGKLPHIR       550       560       570       580       590       600       610       620       630       640       650       660 m163.pepHQTTYKPYAYFFDGRVGYDVQYMNKDELIADILKNYERYLMLLDDVGQELMAHEQVELAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a163HQTTYKPYAYFFDGRVGYDVQYMNKDELIADILKNYERYLMLLDDVGQELMAHEQVELAE       610       620       630       640       650       660 m163.pep X| a163 XThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 679>:

g164.seq (partial) 1..ATGAACACAT TTTTGAAAAA CAGCGAATAC GCGTATATCC TGAACGACTG 51  CAAGGCGCGC TTCCTGTTCG CCTCGGCCGG CCTGTCAAAA GAATTGGCGG 101  GCCTGAAGGC GCAAACGCCC GTCGAAAAAA TCATTTGGAC GGACAAAAGC 151  CGGCCGGCCG GCGAAACGGC GGAAGGCGAT GCCTTTTTTG AAAACGTGCG 201  CCGCTTCCCC GAAAAACCCG ACTTGGGCCG CCAACCCCGG ATAAATGATT 251  TGGCACACAT CATCTACACC TCCGGCACGA CGGGGCATCC CAAAGGCGCG 301  CTAATCAGTT ACGCCAACCT GTTCGCCAAC CTGAACGGCA TCGAACGCAT 351  CTTtaaAATT TCCAAACGCG ACCGCTTTAT CGTTTTCctg ccgatgTTCC 401  ACAGCTTCAC GCTGACGGCT ATGGTGCTGC TGCCGATTTA TATGGCGTGT 451  TCGATTATTT TGGTCAAAtc cgttttCCCc ttttccaacG TTTTGAAACA 501  GGCCCTGCTC AAACGCGCAA CCGTGTTTTT GGGCGTACCC GCGATTTACA 551  CCGCGATGAG CAAGGCAAAA ATCCCTTGGT ATTTCAGATG GTTCAACCGC 601  ATCCGCCTGT TTATCAGCGG CGGCGCGCCT TTGGCGGAAC AAACCATCCT 651  CGATTTTAAA GCCAAGTTCC CCCGCGCCAA ATTGCTGGAA GGCTACGGAC 701  TGAGCGAAGC CTCGCCCGTC GTCGCCGTCA ATACGCCCGA ACGGCAAAAA 751  GCCCGCAGCG TCGGCATCCC CCTGCCCGGT TTGGAAGCCA AAGCCGTCGA 801  TGAAGAATTG GTCGAAGTGC CGCGCGGCGA AGTGGGCGAA CTGATCGTCA 851  GGGGCGGTTC GGTGATGCGG GGCTACCTCA ATATGCCTGC CGCCACCGAT 901  GAAACCATCG TCAACGGCTG GTTGAAAACG GGCGATTTCG TTACCATAGA 951  CGAGGACGGC TTTATCTTTA TCGTCGACCG CAAAAAAGAT TTGATTATTT 1001  CCAAAGGTCA AAACGTCTAT CCGCGCGAGA TCGAAGAAGA AATCCACAAA 1051  CTCGATGCCG TCGAAGCCGC CGCCGTCATC GGCGTGAAAG ACCGTTATGC 1101  CGACGAGGAA ATCGTCGCCT TCGTCCAATT GAAGGAAGGT ATGGATTTGG 1151  GCGAGGACGA aatccgccgc caccTGCGTA CCGTGCTGGC AAATTTCAAA 1201  ATCCCCAAAC AGATCCACTT TAAAGACGGG CTGCCGCGCA ACGCTACGGG 1251  CAAAGTATTG AAACGGGTGC TGAAGGAGCA GTTTGAAGGA AACAAATGAThis corresponds to the amino acid sequence <SEQ ID 680; ORF 164.ng>:

g164.pep (partial) 1..MNTFLKNSEY AYILNDCKAR FLFASAGLSK ELAGLKAQTP VEKIIWTDKS 51  RPAGETAEGD AFFENVRRFP EKPDLGRQPR INDLAHIIYT SGTTGHPKGA 101  LISYANLFAN LNGIERIFKI SKRDRFIVFL PMFHSFTLTA MVLLPIYMAC 151  SIILVKSVFP FSNVLKQALL KRATVFLGVP AIYTAMSKAK IPWYFRWFNR 201  IRLFISGGAP LAEQTILDFK AKFPRAKLLE GYGLSEASPV VAVNTPERQK 251  ARSVGIPLPG LEAKAVDEEL VEVPRGEVGE LIVRGGSVMR GYLNMPAATD 301  ETIVNGWLKT GDFVTIDEDG FIFIVDRKKD LIISKGQNVY PREIEEEIHK 351  LDAVEAAAVI GVKDRYADEE IVAFVQLKEG MDLGEDEIRR HLRTVLANFK 401  IPKQIHFKDG LPRNATGKVL KRVLKEQFEG NK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 681>:

m164.seq 1 ATGAACCGGA CTTATGCCAA TTTCTACGAA ATGCTCGCCG CCGCCTGCCG 51CAAAAACGGA AACGGCACGG CAGTGTTCGA CGGCAAGGAA AAAACCGCCT 101ACCGCGCGCT CAAGCAGGAG GCCGAAGCCG TCGCGGCGTA TCTGCAAAAT 151ATCGGCGTGA AGTTCGGCGA CACGGTCGCG CTGGCGGTTT CCAATTCCAC 201AGAATTTATT ACCGCCTATT TCGCCATCTC CGCCATCGGC GCGGTCGCCG 251TACCGATGAA CACATTTTTG AAAAACAGCG AATACGCGTA TATCCTGAAC 301GACTGCAAGG CGCGCTTCCT GTTCGCCTCG GCCGGCCTGT CAAAAGAATT 351GGCGGGCTTG AAGGCGCAAA CGCCCGTCGA AAAAATCATT TGGACGGACA 401AAAGCCGTCC GACCGGCGAA ACGGCGGAAG GCGATGCCTT TTTTGAAGAC 451GTGCGCCGCT TCCCCGAAAA ACCCGACTTG GGCCGCCAAC CCCGGATAAA 501TGATTTGGCA CACATCATCT ACACCTCCGG CACGACGGGG CATCCCAAAG 551GCGCGCTAAT CAGTTACGCC AACCTGTTCG CCAACCTGAA CGGCATCGAA 601CGCATCTTTA AAATTTCCAA GCGCGACCGC TTTATCGTTT TCCTGCCGAT 651GTTCCACAGC TTCACGCTGA CGGCTATGGT GCTGCTGCCG ATTTATATGG 701CGTGTTCGAT TATTTTGGTC AAATCCGTTT TTCCGTTTTC CAACGTTTTG 751AAACAGACAC TGCTCAAACG CGCGACCGTG TTTTTGGGCG TACCCGCGAT 801TTACACCGCG ATGAGCAAGG CGAAAATCCC TTGGTATTTC AGATGGTTCA 851ACCGCATTCG CCTGTTTATC AGCGGCGGCG CGCCTTTGGC GGAACAAACC 901ATCCTCGATT TCAAAGCCAA GTTCCCCCGC GCCAAATTGC TGGAAGGCTA 951CGGACTGAGC GAAGCCTCTC CCGTCGTCGC CGTCAATACG CCCGAGAGGC 1001AAAAAGCCCG CAGCGTCGGC ATCCCCCTGC CCGGTTTGGA AGCCAAAGCC 1051GTCGATGAAG AATTGGTCGA AGTGCCGCGC GGCGAAGTGG GCGAACTGAT 1101CGTCAGGGGC GGTTCGGTGA TGCGGGGCTA CCTCAATATG CCTGCCGCCA 1151CCGATGAAAC CATCGTCAAC GGCTGGTTGA AAACGGGCGA TTTCGTTACC 1201ATAGACGAAG ACGGCTTTAT CTTTATCGTC GACCGCAAAA AAGATTTGAT 1251TATTTCCAAA GGTCAAAATG TCTATCCGCG CGAGATTGAA GAAGAAATCT 1301ACAAACTCGA TGCCGTCGAA GCCGCCGCCG TCATCGGCGT GAAAGACCGT 1351TATGCCGACG AGGAAATCGT CGCCTTCGTC CAATTGAAGG AAGGTATGGA 1401TTTGGGCGAG AACGAAATCC GCCGCCACCT GCGTACCGTG CTGGCAAATT 1451TCAAAATCCC CAAACAAATC CACTTTAAAG ACGGGCTGCC GCGCAACGCT 1501ACGGGCAAGG TATTGAAACG GGTGTTGAAG GAGCAGTTTG ACGGAAACAA 1551 ATGAThis corresponds to the amino acid sequence <SEQ ID 682; ORF 164>:

m164.pep 1 MNRTYANFYE MLAAACRKNG NGTAVFDGKE KTAYRALKQE AEAVAAYLQN 51IGVKFGDTVA LAVSNSTEFI TAYFAISAIG AVAVPMNTFL KNSEYAYILN 101DCKARFLFAS AGLSKELAGL KAQTPVEKII WTDKSRPTGE TAEGDAFFED 151VRRFPEKPDL GRQPRINDLA HIIYTSGTTG HPKGALISYA NLFANLNGIE 201RIFKISKRDR FIVFLPMFHS FTLTAMVLLP IYMACSIILV KSVFPFSNVL 251KQTLLKRATV FLGVPAIYTA MSKAKIPWYF RWFNRIRLFI SGGAPLAEQT 301ILDFKAKFPR AKLLEGYGLS EASPVVAVNT PERQKARSVG IPLPGLEAKA 351VDEELVEVPR GEVGELIVRG GSVMRGYLNM PAATDETIVN GWLKTGDFVT 401IDEDGFIFIV DRKKDLIISK GQNVYPREIE EEIYKLDAVE AAAVIGVKDR 451YADEEIVAFV QLKEGMDLGE NEIRRHLRTV LANFKIPKQI HFKDGLPRNA 501TGKVLKRVLK EQFDGNK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae m164/g164 98.6%identity in 432 aa overlap

   60        70        80        90       100       110 m164.pepGDTVALAVSNSTEFITAYFAISAIGAVAVPMNTFLKNSEYAYILNDCKARFLFASAGLSK                              |||||||||||||||||||||||||||||| g164                              MNTFLKNSEYAYILNDCKARFLFASAGLSK                                      10        20        30  120       130       140       150       160       170 m164.pepELAGLKAQTPVEKIIWTDKSRPTGETAEGDAFFEDVRRFPEKPDLGRQPRINDLAHIIYT||||||||||||||||||||||:|||||||||||:||||||||||||||||||||||||| g164ELAGLKAQTPVEKIIWTDKSRPAGETAEGDAFFENVRRFPEKPDLGRQPRINDLAHIIYT        40        50        60        70        80        90  180       190       200       210       220       230 m164.pepSGTTGHPKGALISYANLFANLNGIERIFKISKRDRFIVFLPMFHSFTLTAMVLLPIYMAC|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g164SGTTGHPKGALISYANLFANLNGIERIFKISKRDRFIVFLPMFHSFTLTAMVLLPIYMAC       100       110       120       130       140       150  240       250       260       270       280       290 m164.pepSIILVKSVFPFSNVLKQTLLKRATVFLGVPAIYTAMSKAKIPWYFRWFNRIRLFISGGAP|||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||| g164SIILVKSVFPFSNVLKQALLKRATVFLGVPAIYTAMSKAKIPWYFRWFNRIRLFISGGAP       160       170       180       190       200       210  300       310       320       330       340       350 m164.pepLAEQTILDFKAKFPRAKLLEGYGLSEASPVVAVNTPERQKARSVGIPLPGLEAKAVDEEL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g164LAEQTILDFKAKFPRAKLLEGYGLSEASPVVAVNTPERQKARSVGIPLPGLEAKAVDEEL       220       230       240       250       260       270  360       370       380       390       400       410 m164.pepVEVPRGEVGELIVRGGSVMRGYLNMPAATDETIVNGWLKTGDFVTIDEDGFIFIVDRKKD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g164VEVPRGEVGELIVRGGSVMRGYLNMPAATDETIVNGWLKTGDFVTIDEDGFIFIVDRKKD       280       290       300       310       320       330  420       430       440       450       460       470 m164.pepLIISKGQNVYPREIEEEIYKLDAVEAAAVIGVKDRYADEEIVAFVQLKEGMDLGENEIRR||||||||||||||||||:||||||||||||||||||||||||||||||||||||:|||| g164LIISKGQNVYPREIEEEIHKLDAVEAAAVIGVKDRYADEEIVAFVQLKEGMDLGEDEIRR       340       350       360       370       380       390  480       490       500       510 m164.pepHLRTVLANFKIPKQIHFKDGLPRNATGKVLKRVLKEQFDGNKX||||||||||||||||||||||||||||||||||||||:|||| g164HLRTVLANFKIPKQIHFKDGLPRNATGKVLKRVLKEQFEGNKX       400       410       420       430The following partial DNA sequence was identified in N. meningitidis<SEQ ID 683>:

a164.seq 1 ATGAACCGGA CTTATGCCAA TTTCTACGAA ATGCTGACCG CCGCCTGCCG 51CAAAAACGGC AACGGCACGG CAGTGTTCGA CGGCAAGGAA AAAACCGCCT 101ACCGCGCGCT CAAGCAGGAA GCCGAAGCCG TTGCGGCGTA TCTGCAAAAT 151ATCGGCGTGA AGTTCGGCGA CACGGTCGCG CTGGCGGTTT CCAATTCCAC 201GGAATTTATT ACCGCCTATT TCGCCGTATC CGCCATCGGC GCGGTTGCCG 251TACCGATGAA CACATTTTTG AAAAACAGCG AATACGCGTA TATCCTGAAC 301GACTGCAAGG CGCGCTTCCT GTTCGCCTCG GCCGGCCTGT CAAAAGAATT 351GGCGGGCTTG AAGGCGCAAA CGCCCGTCGA AAAAATCATT TGGACGGGCC 401AAAGCCGTCC GGACGGCGAA ATGGCGGAAG GCGATGCCTT TTTTGAAGAC 451GTGCGCCGCT TCCCCGAAAA ACCCGACTTG GGCCGCCAAC CCCGGATAAA 501TGATTTGGCA CACATCATCT ACACCTCCGG CACGACGGGG CATCCCAAAG 551GTGCGCTAAT CAGCTACGCC AACCTGTTCG CCAACCTGAA CGGCATCGAA 601CGCATCTTTA AAATCTCCAA GCGCGACCGC TTTATCGTTT TCCTGCCGAT 651GTTCCACAGC TTCACGCTGA CGGCTATGGT GCTGCTGCCG ATTTATATGG 701CGTGTTCGAT TATTTTGGTC AAATCCGTTT TCCCCTTTTC CAACGTTTTG 751AAACAGGCAC TGCTCAAACG CGCGACCGTG TTTTTGGGCG TGCCCGCGAT 801TTACACCGCG ATGAGCAAGA CGAAAATCCC TTGGTATTTC AGATGGTTCA 851ACCGCATCCG CCTGTTTATC AGCGGCGGAG CACCTTTGGC GGAACAAACC 901ATCCTCGATT TCAAAGCCAA GTTCCCCCGC GCCAAATTGC TGGAAGGCTA 951CGGACTGAGC GAAGCCTCGC CCGTCGTCGC CGTCAATACG CCCGAGAGGC 1001AAAAAGCCCG CAGCGTCGGC ATCCCCCTGC CCGGTTTGGA AGTCAAAGCC 1051GTCGATGAAG AATTGGTCGA AGTGCCGCGC GGCGAAGTGG GCGAACTGAT 1101CGTCAGGGGC GGTTCGGTGA TGCGGGGCTA CCTCAATATG CCTGCCGCCA 1151CCGATGAAAC CATCGTCAAC GGCTGGTTGA AAACGGGCGA TTTCGTTACC 1201ATAGACGAAG ACGGCTTTAT CTTTATCGTC GACCGCAAAA AAGATTTGAT 1251TATTTCCAAA GGTCAAAATG TCTATCCGCG CGAAATCGAA GAAGAAATCT 1301ACAAACTCGA TGCCGTCGAA GCCGCCGCCG TCATCGGCGT GAAAGACCGT 1351TATGCCGACG AGGAAATCGT CGCCTTCGTC CAATTGAAGG AAGGTATGGA 1401TTTGGGCGAG AACGAAATCC GCCGCCACCT GCGTACCGTG CTGGCAAATT 1451TCAAAATCCC CAAACAAATC CACTTTAAAG ACGGGCTGCC GCGCAACGCT 1501ACGGGCAAGG TATTGAAACG GGTGTTGAAG GAGCAGTTTG ACGGAAACAA 1551 ATGAThis corresponds to the amino acid sequence <SEQ ID 684; ORF 164.a>:

a164.pep 1 MNRTYANFYE MLTAACRKNG NGTAVFDGKE KTAYRALKQE AEAVAAYLQN 51IGVKFGDTVA LAVSNSTEFI TAYFAVSAIG AVAVPMNTFL KNSEYAYILN 101DCKARFLFAS AGLSKELAGL KAQTPVEKII WTGQSRPDGE MAEGDAFFED 151VRRFPEKPDL GRQPRINDLA HIIYTSGTTG HPKGALISYA NLFANLNGIE 201RIFKISKRDR FIVFLPMFHS FTLTAMVLLP IYMACSIILV KSVFPFSNVL 251KQALLKRATV FLGVPAIYTA MSKTKIPWYF RWFNRIRLFI SGGAPLAEQT 301ILDFKAKFPR AKLLEGYGLS EASPVVAVNT PERQKARSVG IPLPGLEVKA 351VDEELVEVPR GEVGELIVRG GSVMRGYLNM PAATDETIVN GWLKTGDFVT 401IDEDGFIFIV DRKKDLIISK GQNVYPREIE EEIYKLDAVE AAAVIGVKDR 451YADEEIVAFV QLKEGMDLGE NEIRRHLRTV LANFKIPKQI HFKDGLPRNA 501TGKVLKRVLK EQFDGNK* m164/a164 98.3% identity in 517 aa overlap        10        20        30        40        50        60 m164.pepMNRTYANFYEMLAAACRKNGNGTAVFDGKEKTAYRALKQEAEAVAAYLQNIGVKFGDTVA||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| a164MNRTYANFYEMLTAACRKNGNGTAVFDGKEKTAYRALKQEAEAVAAYLQNIGVKFGDTVA        10        20        30        40        50        60        70        80        90       100       110       120 m164.pepLAVSNSTEFITAYFAISAIGAVAVPMNTFLKNSEYAYILNDCKARFLFASAGLSKELAGL|||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||| a164LAVSNSTEFITAYFAVSAIGAVAVPMNTFLKNSEYAYILNDCKARFLFASAGLSKELAGL        70        80        90       100       110       120       130       140       150       160       170       180 m164.pepKAQTPVEKIIWTDKSRPTGETAEGDAFFEDVRRFPEKPDLGRQPRINDLAHIIYTSGTTG|||||||||||| :||| || ||||||||||||||||||||||||||||||||||||||| a164KAQTPVEKIIWTGQSRPDGEMAEGDAFFEDVRRFPEKPDLGRQPRINDLAHIIYTSGTTG       130       140       150       160       170       180       190       200       210       220       230       240 m164.pepHPKGALISYANLFANLNGIERIFKISKRDRFIVFLPMFHSFTLTAMVLLPIYMACSIILV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a164HPKGALISYANLFANLNGIERIFKISKRDRFIVFLPMFHSFTLTAMVLLPIYMACSIILV       190       200       210       220       230       240       250       260       270       280       290       300 m164.pepKSVFPFSNVLKQTLLKRATVFLGVPAIYTAMSKAKIPWYFRWFNRIRLFISGGAPLAEQT||||||||||||:||||||||||||||||||||:|||||||||||||||||||||||||| a164KSVFPFSNVLKQALLKRATVFLGVPAIYTAMSKTKIPWYFRWFNRIRLFISGGAPLAEQT       250       260       270       280       290       300       310       320       330       340       350       360 m164.pepILDFKAKFPRAKLLEGYGLSEASPVVAVNTPERQKARSVGIPLPGLEAKAVDEELVEVPR|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||| a164ILDFKAKFPRAKLLEGYGLSEASPVVAVNTPERQKARSVGIPLPGLEVKAVDEELVEVPR       310       320       330       340       350       360       370       380       390       400       410       420 m164.pepGEVGELIVRGGSVMRGYLNMPAATDETIVNGWLKTGDFVTIDEDGFIFIVDRKKDLIISK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a164GEVGELIVRGGSVMRGYLNMPAATDETIVNGWLKTGDFVTIDEDGFIFIVDRKKDLIISK       370       380       390       400       410       420       430       440       450       460       470       480 m164.pepGQNVYPREIEEEIYKLDAVEAAAVIGVKDRYADEEIVAFVQLKEGMDLGENEIRRHLRTV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a164GQNVYPREIEEEIYKLDAVEAAAVIGVKDRYADEEIVAFVQLKEGMDLGENEIRRHLRTV       430       440       450       460       470       480       490       500       510 m164.pepLANFKIPKQIHFKDGLPRNATGKVLKRVLKEQFDGNKX|||||||||||||||||||||||||||||||||||||| a164LANFKIPKQIHFKDGLPRNATGKVLKRVLKEQFDGNKX        490       500       510The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 685>:

g165.seq 1 ATGGCTGAAG CGACAGACGT TGTCTTGGTG GGCGGCGGCA TTATGAGCGC 51GACTTTGGGC GTTTTGCTCA AAGAACTCGA ACCGTCTTGG GAAATCACCC 101TGATTGAACG CTTGGAagat gTGGCGTTGG AATCGTCAAA cGCGTGGAAC 151AACGcCGgca CGGGGCATTC CGcGCTGTGc GAATTGAACT AtgcgccGCT 201GGGtgcggac ggcgtcatCA ATCCGGCGCg cgCCCTGAAT ATTGCCGAAC 251AGTTTCATGT CAGCCGCCAG TTTTGGGcga cgctgGTCGC GGAAGGCAAG 301TTGGAagaCA ATTCCTTCAT CAATGCcgtg ccgcatatGT Ctttggtgat 351gAacgaagac cactgCCgtt acCTGCAAAA ACGCTATGAT GTGTTTAAAA 401CGCAGAAACT TTTTGAAAAT ATGGAATTTT CCACCGATCG GAACAAAATT 451TCCGATTGGG CtccgCTGAT TATGCGCGGC CGGgacgaaA ACCAACCCGT 501CGCCGCCAAC TATTCCGCCG Aaggcacgga tgtcgATTTC GGACGGCTGA 551CGCGCCAGAT GGTGAAATAT TTGCAGGGCA AGGGCGTAAA AACCGAGTTC 601AACCGCCACG TCGAAGACAT CAAACGCGAA TCCGACGGCG CGTGGGTGCT 651CAAAACCGCC GATACCCGCA ACCCAGACTG GCAGCTCACC CTCCGCACCC 701GCTTCCTCTT CCTCGGCGCG GGCGGCGGCG CACTGACCCT GCTGCAAAAA 751TCCGGCATCC CCGAAGGCAA AGGCTACGGC GGCTTACCCG TGTCCGGCCT 801GTTCTTCCGC AACAGCAACC CCGAAACCGC CGAACAACAC AACGCCAAAG 851TGTACGGGCA GGCTTCCGTC GGCGCGCCGC CGATGTCCGT CCCGCACCTC 901GACACACGCA ACGTAGACGG CAAACGACAC CTTATGTTCG GTCCTTACGC 951AGGTTTCCGT TCCAACTTCC TCAAGCAAGG CTCGTTTATG GATTTGCCGC 1001TGTCCATCCA TATGGACAAC CTCTATCCTA TGCTGCGCGC CGGCTGGGCG 1051AATATGCCGC TGACCAAATA CcTGCTGGgC gAaTTGCgtt aaThis corresponds to the amino acid sequence <SEQ ID 686; ORF 165.ng>:

g165.pep 1 MAEATDVVLV GGGIMSATLG VLLKELEPSW EITLIERLED VALESSNAWN 51NAGTGHSALC ELNYAPLGAD GVINPARALN IAEQFHVSRQ FWATLVAEGK 101LEDNSFINAV PHMSLVMNED HCRYLQKRYD VFKTQKLFEN MEFSTDRNKI 151SDWAPLIMRG RDENQPVAAN YSAEGTDVDF GRLTRQMVKY LQGKGVKTEF 201NRHVEDIKRE SDGAWVLKTA DTRNPDWQLT LRTRFLFLGA GGGALTLLQK 251SGIPEGKGYG GLPVSGLFFR NSNPETAEQH NAKVYGQASV GAPPMSVPHL 301DTRNVDGKRH LMFGPYAGFR SNFLKQGSFM DLPLSIHMDN LYPMLRAGWA 351NMPLTKYLLG ELR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 687>:

m165.seq (partial) 1ATGGCTGAAG CGACAGACGT TGTCTTGGTG GGCGGCGGCA TTATGAGCGC 51GACTTTGGGC GTTTTGCTCA AAGAACTCGA ACCGTCTTGG GAAATCACCC 101TGATTGAACG CTTGGAAGAT GTGGCGTTGG AATCGTCAAA CGCGTGGAAC 151AACGCCGGCA CGGGGCATTC CGCGCTGTGC GAATTGAACT ATGCGCCGTT 201GGGTGCAAAT GGGATTATCG ATCCGGCGCG CGCCCTCAAT ATTGCCGAAC 251AGTTTCATGT CAGCCGCCAG TTTTGGGCGA CGCTGGTCGC GGAAGGCAAG 301TTGGAAGACA ATTCCTTCAT CAATGCCGTG CCGCATATGT CTTTGGTGAT 351GAATGAAGAC CATTGTTCTT ATCTTCAAAA ACGTTATGAC GCGTTTAAAA 401CCCAAAAACT TTTTGAAAAT ATGGAATTTT CCACCGATCG GAACAAAATT 451TCCGATTGGG CTCCGCTGAT GATGCGCGGC CGGGACGAAA ACCAACCCGT 501CGCCGCCAAC TACTCCGCCG AAGgTACGGA TGTCGATTTC GGACGGCTGA 551CGCGCCAAAT GGTGAAATAT TTGCAGGGCA AGGGCGTAAA AACCGAGTTC 601AACCGCCACG TCGAAGACAT CAAACGCGAA TCCGACGGCG CGTGGGTGCT 651CAAAACCGCC GATACCCGCA ACCCCGACGG GCAGCTCACC CTCCGTACCC 701GCTTCCTCTT CCTCGGCGCG GGCGGCGGCG CGCTGACCCT GCTGCAAAAA 751TCCGGCATCC CCGAAGGCAA AGGCTACGGC GGCTTCCCCG TGTCCGGCCT 801GTTCTTCCGC AACAGCAACC CCGAAACCGC CGAACAACAC AACGCCAAAG 851TGTACGGGCA GGCTTCCGTC GGCGCGCCGC CGATGTCCGT CCCGCACCTC 901GACACACGCA ACGTGGACGG CAAACGCCAC CTTATGTTCG GCCCTTACGC 951AGGCTTCCGT TCCAACTTCC TCAAGCAAGG CTCGCTTATG GATTTGCCGC 1001TGTCCATCCA TATGGACAAC CTCTATCCTA TGCTGTGCGC CGGCTGGGCG 1051AATATGCCGC TGACCAAA...This corresponds to the amino acid sequence <SEQ ID 688; ORF 165>:

m165.pep (partial) 1MAEATDVVLV GGGIMSATLG VLLKELEPSW EITLIERLED VALESSNAWN 51NAGTGHSALC ELNYAPLGAN GIIDPARALN IAEQFHVSRQ FWATLVAEGK 101LEDNSFINAV PHMSLVMNED HCSYLQKRYD AFKTQKLFEN MEFSTDRNKI 151SDWAPLMMRG RDENQPVAAN YSAEGTDVDF GRLTRQMVKY LQGKGVKTEF 201NRHVEDIKRE SDGAWVLKTA DTRNPDGQLT LRTRFLFLGA GGGALTLLQK 251SGIPEGKGYG GFPVSGLFFR NSNPETAEQH NAKVYGQASV GAPPMSVPHL 301DTRNVDGKRH LMFGPYAGFR SNFLKQGSLM DLPLSIHMDN LYPMLCAGWA 351 NMPLTK...Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m165/g165 97.2% identity in 356 aa overlap        10        20        30        40        50        60 m165.pepMAEATDVVLVGGGIMSATLGVLLKELEPSWEITLIERLEDVALESSNAWNNAGTGHSALC|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g165MAEATDVVLVGGGIMSATLGVLLKELEPSWEITLIERLEDVALESSNAWNNAGTGHSALC        10        20        30        40        50        60        70        80        90       100       110       120 m165.pepELNYAPLGANGIIDPARALNIAEQFHVSRQFWATLVAEGKLEDNSFINAVPHMSLVMNED|||||||||:|:|:|||||||||||||||||||||||||||||||||||||||||||||| 8165ELNYAPLGADGVINPARALNIAEQFHVSRQFWATLVAEGKLEDNSFINAVPHMSLVMNED        70        80        90       100       110       120       130       140       150       160       170       180 m165.pepHCSYLQKRYDAFKTQKLFENMEFSTDRNKISDWAPLMMRGRDENQPVAANYSAEGTDVDF |||||||||:|||||||||||||||||||||||||:||||||||||||||||||||||| 8165HCRYLQKRYDVFKTQKLFENMEFSTDRNKISDWAPLIMRGRDENQPVAANYSAEGTDVDF       130       140       150       160       170       180       190       200       210       220       230       240 m165.pepGRLTRQMVKYLQGKGVKTEFNRHVEDIKRESDGAWVLKTADTRNPDGQLTLRTRFLFLGA|||||||||||||||||||||||||||||||||||||||||||||| ||||||||||||| 8165GRLTRQMVKYLQGKGVKTEFNRHVEDIKRESDGAWVLKTADTRNPDWQLTLRTRFLFLGA       190       200       210       220       230       240       250       260       270       280       290       300 m165.pepGGGALTLLQKSGIPEGKGYGGFPVSGLFFRNSNPETAEQHNAKVYGQASVGAPPMSVPHL|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| g165GGGALTLLQKSGIPEGKGYGGLPVSGLFFRNSNPETAEQHNAKVYGQASVGAPPMSVPHL       250       260       270       280       290       300       310       320       330       340       350 m165.pepDTRNVDGKRHLMFGPYAGFRSNFLKQGSLMDLPLSIHMDNLYPMLCAGWANMPLTK||||||||||||||||||||||||||||:|||||||||||||||| |||||||||| 8165DTRNVDGKRHLMFGPYAGFRSNFLKQGSFMDLPLSIHMDNLYPMLRAGWANMPLTKYLLG       310       320       330       340       350       360 8165 ELRXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 689>:

a165.seq 1 ATGGCTGAAG CGACAGACGT TGTCTTGGTG GGCGGCGGCA TTATGAGCGC 51GACTTTGGGC GTTTTGCTCA AAGAACTCGA ACCGTCTTGG GAAATCACCC 101TGATTGAACG CTTGGAAGAT GTGGCGTTGG AATCGTCAAA CGCGTGGAAC 151AACGCCGGCA CGGGGCATTC CGCGCTGTGC GAATTGAACT ATGCGCCGTT 201GGGTGCAAAT GGGATTATCG ATCCGGCGCG CGCCCTCAAT ATTGCCGAAC 251AGTTTCATGT CAGCCGCCAG TTTTGGGCGA CGTTGGTCGC GGAAGGCAAG 301TTGGAAGACA ATTCCTTCAT CAATGCCGTG CCGCATATGT CTTTGGTGAT 351GAATGAAGAC CATTGTTCTT ATCTTCAAAA ACGTTATGAC GCGTTTAAAA 401CCCAAAAACT TTTTGAAAAT ATGGAATTTT CCACCGATCG GAACAAAATT 451TCCGATTGGG CTCCGCTGAT GATGCGCGGC CGGGACGAAA ACCAACCCGT 501CGCCGCCAAC TACTCCGCCG AAGGCACGGA TGTCGATTTC GGACGGCTGA 551CGCGCCAAAT GGTGAAATAT TTGCAGGGCA AGGGCGTAAA AACCGAGTTC 601AACCGCCACG TCGAAGACAT CAAACGCGAA TCCGACGGCG CGTGGGTGCT 651CAAAACCGCC GATACCCGCA ACCCCGACGG GCAGCTCACC CTCCGTACCC 701GCTTCCTCTT CCTCGGCGCG GGCGGCGGCG CGCTGACCCT GCTGCAAAAA 751TCCGGCATCC CCGAAGGCAA AGGCTACGGT GGCTTTCCCG TGTCCGGCCT 801GTTCTTCCGC AACAGCAACC CCGAAACCGC CGAACAACAC AACGCCAAAG 851TGTACGGGCA GGCTTCCGTC GGCGCGCCGC CGATGTCCGT CCCGCACCTC 901GACACACGCA ACGTGGACGG CAAACGCCAC CTTATGTTCG GCCCTTACGC 951AGGCTTCCGT TCCAACTTCC TCAAGCAAGG CTCACTTATG GATTTGCCGC 1001TGTCCATCCA TATGGACAAC CTCTATCCTA TGCTGCGCGC CGGCTGGGCG 1051AATATGCCGC TGACCAAATA CCTGCTGGGC GAATTGCGTA AAACCAAAGA 1101AGAACGCTTC GCCTCCCTGC TGGAATACTA CCCCGAGGCA AACCCCGACG 1151ACTGGGAACT CATCACCGCA GGGCAACGCG TTCAAATCAT TAAAAAAGAC 1201TCCGAAAAAG GCGGCGTGTT GCAGTTTGGT ACGGAGATTG TCGCACACGC 1251CGACGGCTCG CTCGCCGCAT TGCTGGGCGC GTCGCCGGGC GCATCGACCG 1301CCGTGCCGCT GATGATCCGG CTGATGCACC AATGCTTCCC CGAACGCACC 1351CCGTCTTGGG AAGGCCGTCT GAAAGAGCTG GTACCGGGTT ACGGCATCAA 1401GTTGAACGAA AACCCCGAAA GGGCGGATGA AATTATCGCC TATACCGCGA 1451AAGTGTTGGA TATTTAAThis corresponds to the amino acid sequence <SEQ ID 690; ORF 165.a>:

a165.pep 1 MAEATDVVLV GGGIMSATLG VLLKELEPSW EITLIERLED VALESSNAWN 51NAGTGHSALC ELNYAPLGAN GIIDPARALN IAEQFHVSRQ FWATLVAEGK 101LEDNSFINAV PHMSLVMNED HCSYLQKRYD AFKTQKLFEN MEFSTDRNKI 151SDWAPLMMRG RDENQPVAAN YSAEGTDVDF GRLTRQMVKY LQGKGVKTEF 201NRHVEDIKRE SDGAWVLKTA DTRNPDGQLT LRTRFLFLGA GGGALTLLQK 251SGIPEGKGYG GFPVSGLFFR NSNPETAEQH NAKVYGQASV GAPPMSVPHL 301DTRNVDGKRH LMFGPYAGFR SNFLKQGSLM DLPLSIHMDN LYPMLRAGWA 351NMPLTKYLLG ELRKTKEERF ASLLEYYPEA NPDDWELITA GQRVQIIKKD 401SEKGGVLQFG TEIVAHADGS LAALLGASPG ASTAVPLMIR LMHQCFPERT 451PSWEGRLKEL VPGYGIKLNE NPERADEIIA YTAKVLDI* m165/a16599.7% identity in 356 aa overlap        10        20        30        40        50        60 m165.pepMAEATDVVLVGGGIMSATLGVLLKELEPSWEITLIERLEDVALESSNAWNNAGTGHSALC|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a165MAEATDVVLVGGGIMSATLGVLLKELEPSWEITLIERLEDVALESSNAWNNAGTGHSALC        10        20        30        40        50        60        70        80        90       100       110       120 m165.pepELNYAPLGANGIIDPARALNIAEQFHVSRQFWATLVAEGKLEDNSFINAVPHMSLVMNED|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a165ELNYAPLGANGIIDPARALNIAEQFHVSRQFWATLVAEGKLEDNSFINAVPHMSLVMNED        70        80        90       100       110       120       130       140       150       160       170       180 m165.pepHCSYLQKRYDAFKTQKLFENMEFSTDRNKISDWAPLMMRGRDENQPVAANYSAEGTDVDF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a165HCSYLQKRYDAFKTQKLFENMEFSTDRNKISDWAPLMMRGRDENQPVAANYSAEGTDVDF       130       140       150       160       170       180       190       200       210       220       230       240 m165.pepGRLTRQMVKYLQGKGVKTEFNRHVEDIKRESDGAWVLKTADTRNPDGQLTLRTRFLFLGA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a165GRLTRQMVKYLQGKGVKTEFNRHVEDIKRESDGAWVLKTADTRNPDGQLTLRTRFLFLGA       190       200       210       220       230       240       250       260       270       280       290       300 m165.pepGGGALTLLQKSGIPEGKGYGGFPVSGLFFRNSNPETAEQHNAKVYGQASVGAPPMSVPHL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a165GGGALTLLQKSGIPEGKGYGGFPVSGLFFRNSNPETAEQHNAKVYGQASVGAPPMSVPHL       250       260       270       280       290       300       310       320       330       340       350 m165.pepDTRNVDGKRHLMFGPYAGFRSNFLKQGSLMDLPLSIHMDNLYPMLCAGWANMPLTK||||||||||||||||||||||||||||||||||||||||||||| |||||||||| a165DTRNVDGKRHLMFGPYAGFRSNFLKQGSLMDLPLSIHMDNLYPMLRAGWANMPLTKYLLG       310       320       330       340       350       360 a165ELRKTKEERFASLLEYYPEANPDDWELITAGQRVQIIKKDSEKGGVLQFGTEIVAHADGS       370       380       390       400       410       420The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 691>:

g165-1.seq 1 ATGGCTGAAG CGACAGACGT TGTCTTGGTG GGCGGCGGCA TTATGAGCGC 51GACTTTGGGC GTTTTGCTCA AAGAACTCGA ACCGTCTTGG GAAATCACCC 101TGATTGAACG CTTGGAagat gTGGCGTTGG AATCGTCAAA cGCGTGGAAC 151AACGcCGgca CGGGGCATTC CGcGCTGTGc GAATTGAACT AtgcgccGCT 201GGGtgcggac ggcgtcatCA ATCCGGCGCg cgCCCTGAAT ATTGCCGAAC 251AGTTTCATGT CAGCCGCCAG TTTTGGGcga cgctggTCGC GGAAGGCAAG 301TTGGAAGACA ATTCCTTCAT CAATGCCGTG CCGCATATGT CTTTGGTGAT 351GAACGAAGAC CACTGCCGTT ACCTGCAAAA ACGCTATGAT GTGTTTAAAA 401CGCAGAAACT TTTTGAAAAT ATGGAATTTT CCACCGATCG GAACAAAATT 451TCCGATTGGG CtccgCTGAT TATGCGCGGC CGGGACGAAA ACCAACCCGT 501CGCCGCCAAC TATTCCGCCG AAGGCACGGA TGTCGATTTC GGACGGCTGA 551CGCGCCAGAT GGTGAAATAT TTGCAGGGCA AGGGCGTAAA AACCGAGTTC 601AACCGCCACG TCGAAGACAT CAAACGCGAA TCCGACGGCG CGTGGGTGCT 651CAAAACCGCC GATACCCGCA ACCCAGACTG GCAGCTCACC CTCCGCACCC 701GCTTCCTCTT CCTCGGCGCG GGCGGCGGCG CACTGACCCT GCTGCAAAAA 751TCCGGCATCC CCGAAGGCAA AGGCTACGGC GGCTTACCCG TGTCCGGCCT 801GTTCTTCCGC AACAGCAACC CCGAAACCGC CGAACAACAC AACGCCAAAG 851TGTACGGGCA GGCTTCCGTC GGCGCGCCGC CGATGTCCGT CCCGCACCTC 901GACACACGCA ACGTAGACGG CAAACGACAC CTTATGTTCG GTCCTTACGC 951AGGTTTCCGT TCCAACTTCC TCAAGCAAGG CTCGTTTATG GATTTGCCGC 1001TGTCCATCCA TATGGACAAC CTCTATCCTA TGCTGCGCGC CGGCTGGGCG 1051AATATGCCGC TGACCAAATA CCTGCTGGGC GAATTGCGTA AAACCAAAGA 1101AGAACGCTtt gCCTCCCTGC TGgaatacta cccGaggcag acccGACGAc 1151tggtactcat cacgcaggnc acGCGTcata tcattanata tgactCgaaa 1201ctgcgcgtgc tgcagttgta cgagattgtg ccaCGCGacg ctcgctcgcg 1251cattctggag cgtcgcggcg catcacgctn tgcgctgata tccgctgatg 1301acactgctcc gaGCGcgccc gtcttggaaa gtgtctgaThis corresponds to the amino acid sequence <SEQ ID 692; ORF 165-1.ng>:

g165-1.pep 1 MAEATDVVLV GGGIMSATLG VLLKELEPSW EITLIERLED VALESSNAWN 51NAGTGHSALC ELNYAPLGAD GVINPARALN IAEQFHVSRQ FWATLVAEGK 101LEDNSFINAV PHMSLVMNED HCRYLQKRYD VFKTQKLFEN MEFSTDRNKI 151SDWAPLIMRG RDENQPVAAN YSAEGTDVDF GRLTRQMVKY LQGKGVKTEF 201NRHVEDIKRE SDGAWVLKTA DTRNPDWQLT LRTRFLFLGA GGGALTLLQK 251SGIPEGKGYG GLPVSGLFFR NSNPETAEQH NAKVYGQASV GAPPMSVPHL 301DTRNVDGKRH LMFGPYAGFR SNFLKQGSFM DLPLSIHMDN LYPMLRAGWA 351NMPLTKYLLG ELRKTKEERF ASLLEYYPRQ TRRLVLITQX TRHIIXYDSK 401LRVLQLYEIV PRDARSRILE RRGASRXALI SADDTAPSAP VLESV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 693>:

m165-1.seq 1 ATGGCTGAAG CGACAGACGT TGTCTTGGTG GGCGGCGGCA TTATGAGCGC 51GACTTTGGGC GTTTTGCTCA AAGAACTCGA ACCGTCTTGG GAAATCACCC 101TGATTGAACG CTTGGAAGAT GTGGCGTTGG AATCGTCAAA CGCGTGGAAC 151AACGCCGGCA CGGGGCATTC CGCGCTGTGC GAATTGAACT ATGCGCCGTT 201GGGTGCAAAT GGGATTATCG ATCCGGCGCG CGCCCTCAAT ATTGCCGAAC 251AGTTTCATGT CAGCCGCCAG TTTTGGGCGA CGCTGGTCGC GGAAGGCAAG 301TTGGAAGACA ATTCCTTCAT CAATGCCGTG CCGCATATGT CTTTGGTGAT 351GAATGAAGAC CATTGTTCTT ATCTTCAAAA ACGTTATGAC GCGTTTAAAA 401CCCAAAAACT TTTTGAAAAT ATGGAATTTT CCACCGATCG GAACAAAATT 451TCCGATTGGG CTCCGCTGAT GATGCGCGGC CGGGACGAAA ACCAACCCGT 501CGCCGCCAAC TACTCCGCCG AAGGTACGGA TGTCGATTTC GGACGGCTGA 551CGCGCCAAAT GGTGAAATAT TTGCAGGGCA AGGGCGTAAA AACCGAGTTC 601AACCGCCACG TCGAAGACAT CAAACGCGAA TCCGACGGCG CGTGGGTGCT 651CAAAACCGCC GATACCCGCA ACCCCGACGG GCAGCTCACC CTCCGTACCC 701GCTTCCTCTT CCTCGGCGCG GGCGGCGGCG CGCTGACCCT GCTGCAAAAA 751TCCGGCATCC CCGAAGGCAA AGGCTACGGC GGCTTCCCCG TGTCCGGCCT 801GTTCTTCCGC AACAGCAACC CCGAAACCGC CGAACAACAC AACGCCAAAG 851TGTACGGGCA GGCTTCCGTC GGCGCGCCGC CGATGTCCGT CCCGCACCTC 901GACACACGCA ACGTGGACGG CAAACGCCAC CTTATGTTCG GCCCTTACGC 951AGGCTTCCGT TCCAACTTCC TCAAGCAAGG CTCGCTTATG GATTTGCCGC 1001TGTCCATCCA TATGGACAAC CTCTATCCTA TGCTGTGCGC CGGCTGGGCG 1051AATATGCCGC TGACCAAATA CCTGCTGGGC GAATTGCGTA AAACCAAAGA 1101AGAACGCTTC GCCTCCCTGC TGGAATACTA CCCCGAGGCA AACCCCGACG 1151ACTGGGAACT CATCACCGCA GGGCAACGCG TCCAAATCAT TAAAAAAGAC 1201TCCGAAAAAG GCGGCGTGCT CCAGTTTGGT ACGGAGATTG TCGCCCACGC 1251CGACGGCTCA CTCGCCGCAT TGCTGGGCGC GTCGCCGGGC GCATCGACCG 1301CTGTGCCGCT GATGATCCGG CTGATGCACC AATGCTTCCC CGAGCGCGCC 1351CCGTCTTGGG AAGACCGTCT GAAAGAGCTG GTACCGGGTT ACGGCATCAA 1401GTTGAACGAA AACCCTGAAA GGGCGGATGA AATTATCGCC TATACCGCGA 1451AAGTATTGGA TATTTAAThis corresponds to the amino acid sequence <SEQ ID 694; ORF 165-1>:

m165-1.pep 1 MAEATDVVLV GGGIMSATLG VLLKELEPSW EITLIERLED VALESSNAWN 51NAGTGHSALC ELNYAPLGAN GIIDPARALN IAEQFHVSRQ FWATLVAEGK 101LEDNSFINAV PHMSLVMNED HCSYLQKRYD AFKTQKLFEN MEFSTDRNKI 151SDWAPLMMRG RDENQPVAAN YSAEGTDVDF GRLTRQMVKY LQGKGVKTEF 201NRHVEDIKRE SDGAWVLKTA DTRNPDGQLT LRTRFLFLGA GGGALTLLQK 251SGIPEGKGYG GFPVSGLFFR NSNPETAEQH NAKVYGQASV GAPPMSVPHL 301DTRNVDGKRH LMFGPYAGFR SNFLKQGSLM DLPLSIHMDN LYPMLCAGWA 351NMPLTKYLLG ELRKTKEERF ASLLEYYPEA NPDDWELITA GQRVQIIKKD 401SEKGGVLQFG TEIVAHADGS LAALLGASPG ASTAVPLMIR LMHQCFPERA 451PSWEDRLKEL VPGYGIKLNE NPERADEIIA YTAKVLDI* m165-1/g165-189.7% identity in 428 aa overlap        10        20        30        40        50        60 m165-1.pepMAEATDVVLVGGGIMSATLGVLLKELEPSWEITLIERLEDVALESSNAWNNAGTGHSALC|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g165-1MAEATDVVLVGGGIMSATLGVLLKELEPSWEITLIERLEDVALESSNAWNNAGTGHSALC        10        20        30        40        50        60        70        80        90       100       110       120 m165-1.pepELNYAPLGANGIIDPARALNIAEQFHVSRQFWATLVAEGKLEDNSFINAVPHMSLVMNED|||||||||:|:|:|||||||||||||||||||||||||||||||||||||||||||||| g165-1ELNYAPLGADGVINPARALNIAEQFHVSRQFWATLVAEGKLEDNSFINAVPHMSLVMNED        70        80        90       100       110       120       130       140       150       160       170       180 m165-1.pepHCSYLQKRYDAFKTQKLFENMEFSTDRNKISDWAPLMMRGRDENQPVAANYSAEGTDVDF |||||||||:|||||||||||||||||||||||||:||||||||||||||||||||||| g165-1HCRYLQKRYDVFKTQKLFENMEFSTDRNKISDWAPLIMRGRDENQPVAANYSAEGTDVDF       130       140       150       160       170       180       190       200       210       220       230       240 m165-1.pepGRLTRQMVKYLQGKGVKTEFNRHVEDIKRESDGAWVLKTADTRNPDGQLTLRTRFLFLGA|||||||||||||||||||||||||||||||||||||||||||||| ||||||||||||| g165-1GRLTRQMVKYLQGKGVKTEFNRHVEDIKRESDGAWVLKTADTRNPDWQLTLRTRFLFLGA       190       200       210       220       230       240       250       260       270       280       290       300 m165-1.pepGGGALTLLQKSGIPEGKGYGGFPVSGLFFRNSNPETAEQHNAKVYGQASVGAPPMSVPHL|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| g165-1GGGALTLLQKSGIPEGKGYGGLPVSGLFFRNSNPETAEQHNAKVYGQASVGAPPMSVPHL       250       260       270       280       290       300       310       320       330       340       350       360 m165-1.pepDTRNVDGKRHLMFGPYAGFRSNFLKQGSLMDLPLSIHMDNLYPMLCAGWANMPLTKYLLG||||||||||||||||||||||||||||:|||||||||||||||| |||||||||||||| g165-1DTRNVDGKRHLMFGPYAGFRSNFLKQGSFMDLPLSIHMDNLYPMLRAGWANMPLTKYLLG       310       320       330       340       350       360       370       380       390       400       410       420 m165-1.pepELRKTKEERFASLLEYYPEANPDDWELITAGQRVQIIKKDSEKGGVLQFGTEIVAHADGS||||||||||||||||||: :     |||   | :||  || |  |||:|||:   | : g165-1ELRKTKEERFASLLEYYPR-QTRRLVLITQXTR-HIIXYDS-KLRVLQLYEIVPRDARSR       370        380       390         400       410       430       440       450       460       470       480 m165-1.pepLAALLGASPGASTAVPLMIRLMHQCFPERAPSWEDRLKELVPGYGIKLNENPERADEIIA :    |||g165-1 ILERRGASRXALISADDTAPSAPVLESVX 420       430       440The following partial DNA sequence was identified in N. meningitidis<SEQ ID 695>:

a165-1.seq 1 ATGGCTGAAG CGACAGACGT TGTCTTGGTG GGCGGCGGCA TTATGAGCGC 51GACTTTGGGC GTTTTGCTCA AAGAACTCGA ACCGTCTTGG GAAATCACCC 101TGATTGAACG CTTGGAAGAT GTGGCGTTGG AATCGTCAAA CGCGTGGAAC 151AACGCCGGCA CGGGGCATTC CGCGCTGTGC GAATTGAACT ATGCGCCGTT 201GGGTGCAAAT GGGATTATCG ATCCGGCGCG CGCCCTCAAT ATTGCCGAAC 251AGTTTCATGT CAGCCGCCAG TTTTGGGCGA CGTTGGTCGC GGAAGGCAAG 301TTGGAAGACA ATTCCTTCAT CAATGCCGTG CCGCATATGT CTTTGGTGAT 351GAATGAAGAC CATTGTTCTT ATCTTCAAAA ACGTTATGAC GCGTTTAAAA 401CCCAAAAACT TTTTGAAAAT ATGGAATTTT CCACCGATCG GAACAAAATT 451TCCGATTGGG CTCCGCTGAT GATGCGCGGC CGGGACGAAA ACCAACCCGT 501CGCCGCCAAC TACTCCGCCG AAGGCACGGA TGTCGATTTC GGACGGCTGA 551CGCGCCAAAT GGTGAAATAT TTGCAGGGCA AGGGCGTAAA AACCGAGTTC 601AACCGCCACG TCGAAGACAT CAAACGCGAA TCCGACGGCG CGTGGGTGCT 651CAAAACCGCC GATACCCGCA ACCCCGACGG GCAGCTCACC CTCCGTACCC 701GCTTCCTCTT CCTCGGCGCG GGCGGCGGCG CGCTGACCCT GCTGCAAAAA 751TCCGGCATCC CCGAAGGCAA AGGCTACGGT GGCTTTCCCG TGTCCGGCCT 801GTTCTTCCGC AACAGCAACC CCGAAACCGC CGAACAACAC AACGCCAAAG 851TGTACGGGCA GGCTTCCGTC GGCGCGCCGC CGATGTCCGT CCCGCACCTC 901GACACACGCA ACGTGGACGG CAAACGCCAC CTTATGTTCG GCCCTTACGC 951AGGCTTCCGT TCCAACTTCC TCAAGCAAGG CTCACTTATG GATTTGCCGC 1001TGTCCATCCA TATGGACAAC CTCTATCCTA TGCTGCGCGC CGGCTGGGCG 1051AATATGCCGC TGACCAAATA CCTGCTGGGC GAATTGCGTA AAACCAAAGA 1101AGAACGCTTC GCCTCCCTGC TGGAATACTA CCCCGAGGCA AACCCCGACG 1151ACTGGGAACT CATCACCGCA GGGCAACGCG TTCAAATCAT TAAAAAAGAC 1201TCCGAAAAAG GCGGCGTGTT GCAGTTTGGT ACGGAGATTG TCGCACACGC 1251CGACGGCTCG CTCGCCGCAT TGCTGGGCGC GTCGCCGGGC GCATCGACCG 1301CCGTGCCGCT GATGATCCGG CTGATGCACC AATGCTTCCC CGAACGCACC 1351CCGTCTTGGG AAGGCCGTCT GAAAGAGCTG GTACCGGGTT ACGGCATCAA 1401GTTGAACGAA AACCCCGAAA GGGCGGATGA AATTATCGCC TATACCGCGA 1451AAGTGTTGGA TATTTAAThis corresponds to the amino acid sequence <SEQ ID 696; ORF 165-1.a>:

a165-1.pep 1 MAEATDVVLV GGGIMSATLG VLLKELEPSW EITLIERLED VALESSNAWN 51NAGTGHSALC ELNYAPLGAN GIIDPARALN IAEQFHVSRQ FWATLVAEGK 101LEDNSFINAV PHMSLVMNED HCSYLQKRYD AFKTQKLFEN MEFSTDRNKI 151SDWAPLMMRG RDENQPVAAN YSAEGTDVDF GRLTRQMVKY LQGKGVKTEF 201NRHVEDIKRE SDGAWVLKTA DTRNPDGQLT LRTRFLFLGA GGGALTLLQK 251SGIPEGKGYG GFPVSGLFFR NSNPETAEQH NAKVYGQASV GAPPMSVPHL 301DTRNVDGKRH LMFGPYAGFR SNFLKQGSLM DLPLSIHMDN LYPMLRAGWA 351NMPLTKYLLG ELRKTKEERF ASLLEYYPEA NPDDWELITA GQRVQIIKKD 401SEKGGVLQFG TEIVAHADGS LAALLGASPG ASTAVPLMIR LMHQCFPERT 451PSWEGRLKEL VPGYGIKLNE NPERADEIIA YTAKVLDI* a165-1/m165-199.4% identity in 488 aa overlap        10        20        30        40        50        60 a165-1.pepMAEATDVVLVGGGIMSATLGVLLKELEPSWEITLIERLEDVALESSNAWNNAGTGHSALC|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m165-1MAEATDVVLVGGGIMSATLGVLLKELEPSWEITLIERLEDVALESSNAWNNAGTGHSALC        10        20        30        40        50        60        70        80        90       100       110       120 a165-1.pepELNYAPLGANGIIDPARALNIAEQFHVSRQFWATLVAEGKLEDNSFINAVPHMSLVMNED|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m165-1ELNYAPLGANGIIDPARALNIAEQFHVSRQFWATLVAEGKLEDNSFINAVPHMSLVMNED        70        80        90       100       110       120       130       140       150       160       170       180 a165-1.pepHCSYLQKRYDAFKTQKLFENMEFSTDRNKISDWAPLMMRGRDENQPVAANYSAEGTDVDF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m165-1HCSYLQKRYDAFKTQKLFENMEFSTDRNKISDWAPLMMRGRDENQPVAANYSAEGTDVDF       130       140       150       160       170       180       190       200       210       220       230       240 a165-1.pepGRLTRQMVKYLQGKGVKTEFNRHVEDIKRESDGAWVLKTADTRNPDGQLTLRTRFLFLGA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m165-1GRLTRQMVKYLQGKGVKTEFNRHVEDIKRESDGAWVLKTADTRNPDGQLTLRTRFLFLGA       190       200       210       220       230       240       250       260       270       280       290       300 a165-1.pepGGGALTLLQKSGIPEGKGYGGFPVSGLFFRNSNPETAEQHNAKVYGQASVGAPPMSVPHL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m165-1GGGALTLLQKSGIPEGKGYGGFPVSGLFFRNSNPETAEQHNAKVYGQASVGAPPMSVPHL       250       260       270       280       290       300       310       320       330       340       350       360 a165-1.pepDTRNVDGKRHLMFGPYAGFRSNFLKQGSLMDLPLSIHMDNLYPMLRAGWANMPLTKYLLG||||||||||||||||||||||||||||||||||||||||||||| |||||||||||||| m165-1DTRNVDGKRHLMFGPYAGFRSNFLKQGSLMDLPLSIHMDNLYPMLCAGWANMPLTKYLLG       310       320       330       340       350       360       370       380       390       400       410       420 a165-1.pepELRKTKEERFASLLEYYPEANPDDWELITAGQRVQIIKKDSEKGGVLQFGTEIVAHADGS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m165-1ELRKTKEERFASLLEYYPEANPDDWELITAGQRVQIIKKDSEKGGVLQFGTEIVAHADGS       370       380       390       400       410       420       430       440       450       460       470       480 a165-1.pepLAALLGASPGASTAVPLMIRLMHQCFPERTPSWEGRLKELVPGYGIKLNENPERADEIIA|||||||||||||||||||||||||||||:|||| ||||||||||||||||||||||||| m165-1LAALLGASPGASTAVPLMIRLMHQCFPERAPSWEDRLKELVPGYGIKLNENPERADEIIA       430       440       450       460       470       480       489a165-1.pep YTAKVLDIX ||||||||| m165-1 YTAKVLDIX a165-1/p33940sp|P33940|YOJH_ECOLI HYPOTHETICAL 60.2 KD PROTEIN IN ECO-ALKBINTERGENIC REGION >gi|1736851|gnl|PID|d1016718 (D90850)ORF_ID: o372#5; similar to [SwissProt Accession Number P33940][Escherichia coli] >gi|1788539 (AE000310) f548;This 548 aa ORF is 100 pct identical to490 residues of YOJH_ECOLI SW: P33940 (492 aa) but contains56 additional N-ter aa; 100 pct identical to GB: ECOHU49_33ACCESSION: U00008 (490 aa) but contains 58 aditionalN-term resi... Length = 548 Score = 458 bits (1167), Expect = e−128Identities = 233/490 (47%), Positives = 303/490 (61%), Gaps = 5/490 (1%)Query: 3 EATDVVLVGGGIMSATLGVLLKELEPSWEITLIERLEDVALESSNAWNNAGTGHSALCEL62 + TDV+L+GGGIMSATLG  L+ELEP W +T++ERLE VA ESSN WNNAGTGHSAL EL Sbjct:30 QETDVLLIGGGIMSATLGTYLRELEPEWSMTMVERLEGVAQESSNGWNNAGTGHSALMEL 89Query: 63 NYAPLGANGIIDPARALNIAEQFHVSRQFWATLVAEGKLED-NSFINAVPHMSLVMNEDH121 NY P  A+G I   +A+ I E F +SRQFWA  V  G L    SFIN VPHMS V  ED+ Sbjct:90 NYTPQNADGSISIEKAVAINEAFQISRQFWAHQVERGVLRTPRSFINTVPHMSFVWGEDN 149Query: 122 CSYLQKRYDAFKTQKLFENMEFSTDRNKISDWAPLMMRGRDENQPVAANYSAEGTDVDFG181 ++L+ RY A +   LF  M +S D  +I +WAPL+M GRD  Q VAA  +  GTDV++G Sbjct:150 VNFLRARYAALQQSSLFRGMRYSEDHAQIKEWAPLVMEGRDPQQKVAATRTEIGTDVNYG 209Query: 182 RLTRQMVKYLQGKG-VKTEFNRHVEDIKRESDGAWVLKTADTRNPDGQLTXXXXXXXXXX240  +TRQ++  LQ K     + +  V  +KR  D  W +  AD +N   Q Sbjct: 210EITRQLIASLQKKSNFSLQLSSEVRALKRNDDNTWTVTVADLKNGTAQ-NIRAKFVFIGA 268 Query:241 XXXXXXXXQKSGIPEGKGYGGFPVSGLFFRNSNPETAEQHNAKVYGQASVGAPPMSVPHL 300        Q+SGIPE K Y GFPV G F  + NP+    H AKVYG+ASVGAPPMSVPH+ Sbjct: 269GGAALKLLQESGIPEAKDYAGFPVGGQFLVSENPDVVNHHLAKVYGKASVGAPPMSVPHI 328 Query:301 DTRNVDGKRHLMFGPYAGFRSNFLKQGSLMDLPLSIHMDNLYPMLRAGWANMPLTKYLLG 360DTR +DGKR ++FGP+A F + FLK GSL DL  S    N+ PM+  G  N  L KYL+ Sbjct: 329DTRVLDGKRVVLFGPFATFSTKFLKNGSLWDLMSSTTTSNVMPMMHVGLDNFDLVKYLVS 388 Query:361 ELRKTKEERFASLLEYYPEANPDDWELITAGQRVQIIKKDSEKGGVLQFGTEIVXXXXXX 420 ++ ++E+RF +L EYYP+A  +DW L  AGQRVQIIK+D+EKGGVL+ GTE+V Sbjct: 389QVMLSEEDRFEALKEYYPQAKKEDWRLWQAGQRVQIIKRDAEKGGVLRLGTEVVSDQQGT 448 Query:421 XXXXXXXXXXXXXXVPLMIRLMHQCFPER--TPSWEGRLKELVPGYGIKLNENPERADEI 478               P+M+ L+ + F +R  +P W+  LK +VP YG KLN +    + Sbjct: 449IAALLGASPGASTAAPIMLNLLEKVFGDRVSSPQWQATLKAIVPSYGRKLNGDVAATERE 508 Query:479 IAYTAKVLDI 488 + YT++VL + Sbjct: 509 LQYTSEVLGL 518The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 697>:

g204.seq 1 atggcggcgg cggaaataaa acgccccctc gctgtcgatt tccagcacat 51agcgtccgtt ctgcacggcg gcatagccgc ttttgcctgc ctgatagggt 101tgcagggcgg aatgcgaaat caggtaatca gtcagtttgc cgccgtcttc 151ggcgatattg cccaccagtt tggcaaacaa ggtatggcac acgccgtttt 201ccgcccagcc cgaaggcgcg tcctttccgt cggtttccat acatttgccg 251acgacggctt ccaagtcgtt gggatgcttt ccggtcagcc ggacggcgtt 301ttgttccggc aagcctttaa tcggataact gatttgtttt ttgccgtcgt 351tggttttgcc ttcgctactt tgtcccaaag ccaaaccggc aatcgccgta 401ttgtcgatgt atttgacttt gaaaaccggt ttcggcgcgc tttgtgccgc 451attttgcggc tgttccgccg tattttcgga tttgccgcag gcggcaagca 501gcaggcagcc gcccaacacg gcaaaaggta ttttcagcat tccgcactcc 551tgatggtttc aaaatgccgt ctgaaatgcc gtctgaaacg tggcaggcgg 601aggttcggac ggcattgggt ttatttcaac gggcggatgc cgaccgcatc 651gcgtacttta tccaacaatt cgcgcgcttc tttgcgcgct ttttgcgcgc 701ctgcctgcaa aatctcttcg atttgcgaag gattagaggt caatgcgttg 751 tagThis corresponds to the amino acid sequence <SEQ ID 698; ORF 204.ng>:

g204.pep 1 MAAAEIKRPL AVDFQHIASV LHGGIAAFAC LIGLQGGMRN QVISQFAAVF 51GDIAHQFGKQ GMAHAVFRPA RRRVLSVGFH TFADDGFQVV GMLSGQPDGV 101LFRQAFNRIT DLFFAVVGFA FATLSQSQTG NRRIVDVFDF ENRFRRALCR 151ILRLFRRIFG FAAGGKQQAA AQHGKRYFQH SALLMVSKCR LKCRLKRGRR 201RFGRHWVYFN GRMPTASRTL SNNSRASLRA FCAPACKISS ICEGLEVNAL 251 *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 699>:

m204.seq 1 ATGGCGGCGG CGGAAATAAA ACGCCCCTTC GCTGTCGATT TCCAGCACAT 51AGCGTCCGTT CTGCACGGCG GCATAGCCGC TTTTGCCTGC CTGATAGGGT 101TGCAGGGCGG CATGCGAAAC TAGGTAATCC GTCAGTTTGC CGCCGTCTTC 151GGCGATATTG CCCACCAGTT TGGCAAACAA GGTATGGCAC ACGCCGTTTT 201CTGCCCAACC TGCCGGACTG TCCTTATCAT CGGTTTCCAT ACATTTGCCG 251CTGACGGCTT CCAAGTCGCC GGGATGCTTG CCGATCAGTC GGATAACATT 301TTGTTCCGGC AAGCCTTTAA TCGGATAACT GATTTGTTTT TTGCCGTCGT 351TGGTTTTGCC TTCGCTGCTT TGTCCCAAAT CCAAACCGGC AATCGCCGTA 401TTGTCGATAT ATATGACTTT GAAAACCGGT TTCGGCGCGC TTTGTACCGC 451GTTTTGCGGC TGTACCGCCG TATTTwCGGA TTTGCCGCaC GGCaArGCAG 501CAGGCAGCCG CCCAATACGG CAAAArAwGT wTTCAGCATT CCACAyTCCT 551GATGGTTTCA AAATGCCGTC TGAAACGCGG CAGGCGGAGG TTCGGACGGC 601ATCGGGTTCA TTTCAACGGG CGGATGcCGA CCGCATCgGT ACTTTGTCCA 651ATAATTCGCG TGCTTCTTTA CGCGCTTTCG CCGCGCCTGC CTGCAAAATC 701TCTTCGATTT GCGAAGGGTC GGCGGTCAGC TCGTTGTAGThis corresponds to the amino acid sequence <SEQ ID 700; ORF 204>:

m204.pep 1 MAAAEIKRPF AVDFQHIASV LHGGIAAFAC LIGLQGGMRN *VIRQFAAVF 51GDIAHQFGKQ GMAHAVFCPT CRTVLIIGFH TFAADGFQVA GMLADQSDNI 101LFRQAFNRIT DLFFAVVGFA FAALSQIQTG NRRIVDIYDF ENRFRRALYR 151VLRLYRRIXG FAATAXQQAA AQYGKXXXQH STXLMVSKCR LKRGRRRFGR 201HRVHFNGRMP TASGTLSNNS RASLRAFAAP ACKISSICEG SAVSSL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae ORF 204 shows 82.0%identity over a 250 aa overlap with a predicted ORF (ORF 204.ng) from N.gonorrhoeae:

m204/g204         10        20        30        40        50        60m204.pep MAAAEIKRPFAVDFQHIASVLHGGIAAFACLIGLQGGMRNXVIRQFAAVFGDIAHQFGKQ|||||||||:|||||||||||||||||||||||||||||| || |||||||||||||||| g204MAAAEIKRPLAVDFQHIASVLHGGIAAFACLIGLQGGMRNQVISQFAAVFGDIAHQFGKQ        10        20        30        40        50        60        70        80        90       100       110       120 m204.pepGMAHAVFCPTCRTVLIIGFHTFAADGFQVAGMLADQSDNILFRQAFNRITDLFFAVVGFA ||||||||: | || :|||||| |||||:|||: | |::|||||||||||||||||||| g204GMAHAVFRPARRRVLSVGFHTFADDGFQVVGMLSGQPDGVLFRQAFNRITDLFFAVVGFA        70        80        90       100       110       120       130       140       150       160       170       180 m204.pepFAALSQIQTGNRRIVDIYDFENRFRRALYRVLRLYRRIXGFAATAXQQAAAQYGKXXXQH ||:||||||||||||::|||||||||| |:|||:||| |||| : ||||||:||   || g204FATLSQSQTGNRRIVDVFDFENRFRRALCRILRLFRRIFGFAAGGKQQAAAQHGKRYFQH       130       140       150       160       170       180       190           200       210       220       230 m204.pepSTXLMVSKCRLK----RGRRRFGRHRVHFNGRMPTASGTLSNNSRASLRAFAAPACKISS|: |||||||||    ||||||||| |:||||||||| ||||||||||||| |||||||| g204SALLMVSKCRLKCRLKRGRRRFGRHWVYFNGRMPTASRTLSNNSRASLRAFCAPACKISS       190       200       210       220       230       240  240m204.pep ICEGSAVSSL X |||| |::| g204 ICEGLEVNAL        250The following partial DNA sequence was identified in N. meningitidis<SEQ ID 701>:

a204.seq 1 ATGGCGGCGG CGGAAATAAA ACGCCCCCTC GCTGTCGATT TCCAGCACAT 51AGCGTCCGTT CTGCACGGCG GCATAGCCGC TTTTGCCTGC CTGATAGGGT 101TGCAGGGCGG AATGCGAAAT CAGGTAATCC GTCAGTTTGC CGCCGTCTTC 151GGCGATATTG CCCACCAGTT TGGCAAACAA GGTATGGCAC ACGCCGTTTG 201CCGCCCAGCC CGAAGGCGCG CCCTTTCCGT CGGTTTCCAT ACATTTGCCG 251ACGACGGCTT CCAAGTCGTT GGGATGCTTG CCGGTCAGCC GGACGACGTT 301TTGTTCCGGC AAGCCTTT.. .......... .......... .......... 351.......... .......... .......... .......... .......... 401.......... .......... .......... .......... .......... 451.......... .......... .......... .......... .......... 501.......... .......... .......... .......... .......... 551.......... .......... .......... .....AAGAG GTTCGGACGG 601CATTGGGTTT ATTTCAACGG GCGGATACCG ACCGCATCAC GTACTTTGCC 651CAATAATTCG CGTGCTTCTT TACGCGCTTT TTGCGCGCCT GCCTGCAAAA 701TCTCTTCGAT TTGCGAAGGG TCGGCGGTCA GCTCGTTGTA GThis corresponds to the amino acid sequence <SEQ ID 702; ORF 204.a>:

a204.pep 1 MAAAEIKRPL AVDFQHIASV LHGGIAAFAC LIGLQGGMRN QVIRQFAAVF 51GDIAHQFGKQ GMAHAVCRPA RRRALSVGFH TFADDGFQVV GMLAGQPDDV 101LFRQAF.... .......... .......... .......... .......... 151.......... .......... .......... .......... .....KRFGR 201HWVYFNGRIP TASRTLPNNS RASLRAFCAP ACKISSICEG SAVSSL* m204/a20454.5% identity in 246 aa overlap        10        20        30        40        50        60 m204.pepMAAAEIKRPFAVDFQHIASVLHGGIAAFACLIGLQGGMRNXVIRQFAAVFGDIAHQFGKQ|||||||||:|||||||||||||||||||||||||||||| ||||||||||||||||||| a204MAAAEIKRPLAVDFQHIASVLHGGIAAFACLIGLQGGMRNQVIRQFAAVFGDIAHQFGKQ        10        20        30        40        50        60        70        80        90       100       110       120 m204.pepGMAHAVFCPTCRTVLIIGFHTFAADGFQVAGMLADQSDNILFRQAFNRILDLFFAVVGFA |||||| |: | :| :|||||| |||||:|||| | |::|||||| a204GMAHAVCRPARRRALSVGFHTFADDGFQVVGMLAGQPDDVLFRQAF--------------        70        80        90       100       130       140       150       160       170       180 m204.pepFAALSQIQTGNRRIVDIYDFENRFRRALYRVLRLYRRIXGFAATAXQQAAAQYGKXXXQH a204------------------------------------------------------------       190       200       210       220       230       240 m204.pepSTXLMVSKCRLKRGRRRFGRHRVHFNGRMPTASGTLSNNSRASLRAFAAPACKISSICEG               :||||| |:||||:|||| ||||||||||||| |||||||||||| a204---------------KRFGRHWVYFNGRIPTASRTLPNNSRASLRAFCAPACKISSICEG                110       120       130       140       150 m204.pepSAVSSLX ||||||| a204 SAVSSLXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 703>:

g205.seq 1 atgctgaaaa taccttttgc cgtgttgggc ggctgcctgc tgcttgccgc 51ctgcggcaaa tccgaaaata cggcggaaca gccgcaaaat gcggcacaaa 101gcgcgccgaa accggttttc aaagtcaaat acatcgacaa tacggcgatt 151gccggtttgg ctttgggaca aagtagcgaa ggcaaaacca acgacggcaa 201aaaacaaatc agttatccga ttaaaggctt gccggaacaa aacgccgtcc 251ggctgaccgg aaagcatccc aacgacttgg aagccgtcgt cggcaaatgt 301atggaaaccg acggaaagga cgcgccttcg ggctgggcgg aaaacggcgt 351gtgccatacc ttgtttgcca aactggtggg caatatcgcc gaagacggcg 401gcaaactgac tgattacctg atttcgcatt ccgccctgca accctatcag 451gcaggcaaaa gcggctatgc cgccgtgcag aacggacgct atgtgctgga 501aatcgacagc gagggggcgt tttatttccg ccgccgccat tattgaThis corresponds to the amino acid sequence <SEQ ID 704; ORF 205.ng>:

g205.pep 1 MLKIPFAVLG GCLLLAACGK SENTAEQPQN AAQSAPKPVF KVKYIDNTAI 51AGLALGQSSE GKTNDGKKQI SYPIKGLPEQ NAVRLTGKHP NDLEAVVGKC 101METDGKDAPS GWAENGVCHT LFAKLVGNIA EDGGKLTDYL ISHSALQPYQ 151AGKSGYAAVQ NGRYVLEIDS EGAFYFRRRH YThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 705>:

m205.seq 1 ATGCTGAAwA CwTyTTTTGC CGTATTGGGC GGCTGCCTGC TGCyTtGCCG 51tGCGGCAAAT CCGwAAATAC GGCGGTACAG CCGCAAAACG CGGTACAAAG 101 CGCGCCGAAACCGGTTTTCA AAGTCATATA TATCGACAAT ACGGCGATTG 151 CCGGTTTGGA TTTGGGACAAAGCAGCGAAG GCAAAACCAA CGACGGCAAA 201 AAACAAATCA GTTATCCGAT TAAAGGCTTGCCGGAACAAA ATGTTATCCG 251 ACTGATCGGC AAGCATCCCG GCGACTTGGA AGCCGTCAGCGGCAAATGTA 301 TGGAAACCGA TGATAAGGAC AGTCCGGCAG GTTGGGCAGA AAACGGCGTG351 TGCCATACCT TGTTTGCCAA ACTGGTGGGC AATATCGCCG AAGACGGCGG 401CAAACTGACG GATTACCTAG TTTCGCATGC CGCCCTGCAA CCCTATCAGG 451 CAGGCAAAAGCGGCTATGCC GCCGTGCAGA ACGGACGCTA TGTGCTGGAA 501 ATCGACAGCG AAGGGGCGTTTTATTTCCGC CGCCGCCATT ATTGAThis corresponds to the amino acid sequence <SEQ ID 706; ORF 205>:

m205.pep 1 MLXTXFAVLG GCLLXCRCGK SXNTAVQPQN AVQSAPKPVF KVIYIDNTAI 51AGLDLGQSSE GKTNDGKKQI SYPIKGLPEQ NVIRLIGKHP GDLEAVSGKC 101 METDDKDSPAGWAENGVCHT LFAKLVGNIA EDGGKLTDYL VSHAALQPYQ 151 AGKSGYAAVQ NGRYVLEIDSEGAFYFRRRH Y*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae ORF 205 shows 88.4%identity over a 181 aa overlap with a predicted ORF (ORF 205.ng) from N.gonorrhoeae:

m205/g205         10        20        30        40        50        60m205.pep MLXTXFAVLGGCLLXCRCGKSXNTAVQPQNAVQSAPKPVFKVIYIDNTAIAGLDLGQSSEII   |||||||||   |||| ||| |||||:|||||||||| |||||||||| |||||| g205MLKIPFAVLGGCLLLAACGKSENTAEQPQNAAQSAPKPVFKVKYIDNTAIAGLALGQSSE        10        20        30        40        50        60        70        80        90       100       110       120 m205.pepGKTNDGKKQISYPIKGLPEQNVIRLIGKHPGDLEAVSGKCMETDDKDSPAGWAENGVCHT|||||||||||||||||||||::|| ||||:||||| ||||||| ||:|:|||||||||| g205GKTNDGKKQISYPIKGLPEQNAVRLTGKHPNDLEAVVGKCMETDGKDAPSGWAENGVCHT        70        80        90       100       110       120       130       140       150       160       170       180 m205.pepLFAKLVGNIAEDGGKLTDYLVSHAALQPYQAGKSGYAAVQNGRYVLEIDSEGAFYFRRRH||||||||||||||||||||:||:|||||||||||||||||||||||||||||||||||| g205LFAKLVGNIAEDGGKLTDYLISHSALQPYQAGKSGYAAVQNGRYVLEIDSEGAFYFRRRH       130       140       150       160       170       180 m205.pep YX| g205 YThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 707>:

a205.seq (partial) 1 TCCGAACCTC TTAAAGGCTT GCCGGAACAA AACGTCGTCCGGCTGACCGG 51 CAAGCATCCC AACGACTTGG AAGCCGTCGT CGGCAAATGT ATGGAAACCG 101ACGGAAAGGG CGCGCCTTCG GGCTGGGCGG CAAACGGCGT GTGCCATACC 151 TTGTTTGCCAAACTGGTGGG CAATATCGCC GAAGACGGCG GCAAACTGAC 201 GGATTACCTG ATTTCGCATTCCGCCCTGCA ACCCTATCAG GCAGGCAAAA 251 GCGGCTATGC CGCCGTGCAG AACGGACGCTATGTGCTGGA AATCGACAGC 301 GAGGGGGCGT TTTATTTCCG CCGCCGCCAT TATTGAThis corresponds to the amino acid sequence <SEQ ID 708; ORF 205.a>:

a205.pep (partial) 1 SEPLKGLPEQ NVVRLTGKHP NDLEAVVGKC METDGKGAPSGWAANGVCHT 51 LFAKLVGNIA EDGGKLTDYL ISHSALQPYQ AGKSGYAAVQ NGRYVLEIDS 101EGAFYFRRRH Y* m205/a205 88.3% identity in 111 aa overlap        50        60        70        80        90       100 m205.pepKVIYIDNTAIAGLDLGQSSEGKTNDGKKQISYPIKGLPEQNVIRLIGKHPGDLEAVSGKC                              | |:||||||||:|| ||||:||||| ||| a205                              SEPLKGLPEQNVVRLTGKHPNDLEAVVGKC                                      10        20        30       110       120       130       140       150       160 m205.pepMETDDKDSPAGWAENGVCHTLFAKLVGNIAEDGGKLTDYLVSHAALQPYQAGKSGYAAVQ|||| | :|:||| ||||||||||||||||||||||||||:||:|||||||||||||||| a205METDGKGAPSGWAANGVCHTLFAKLVGNIAEDGGKLTDYLISHSALQPYQAGKSGYAAVQ        40        50        60        70        80        90       170       180 m205.pep NGRYVLEIDSEGAFYFRRRHYX|||||||||||||||||||||| a205 NGRYVLEIDSEGAFYFRRRHYX        100       110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 709>:

g205-1.seq (partial) 1 ATGCTGAAAA TAcCTTTTGC CGTGTTGGGC GGCTGCCTGCTGCTTGCCGC 51 CTGCGGCAAA TCCGAAAATA CGGCGGAACA GCCGCAAAAT GCGGCACAAA 101GCGCGCCGAA ACCGGTTTTC AAAGTCAAAT ACATCGACAA TACGGCGATT 151 GCCGGTTTGGCTTTGGGACA AAGTAGCGAA GGCAAAACCA ACGACGGCAA 201 AAAACAAATC AGTTATCCGATTAAAGGCTT GCCGGAACAA AACGCCGTCC 251 GGCTGACCGG AAAGCATCCC AACGACTTGGAAGCCGTCGT CGGCAAATGT 301 ATGGAAACCG ACGGAAAGGA CGCGCCTTCG GGCTGGGCGGAAAACGGCGT 351 GTGCCATACC TTGTTTGCCA AACTGGTGGG CAATATCGCC GAAGACGGCG401 GCAAACTGAC TGATTACCTG ATTTCGCATT CCGCCCTGCA ACCCTATCAG 451GCAGGCAAAA GCGGCTATGC CGCCGTGCAG AACGGACGCT ATGTGCTGGA 501 AATCGACAGCGAGGGGGCGT TTTAThis corresponds to the amino acid sequence <SEQ ID 710; ORF 205-1.ng>:

g205-1.pep (partial). 1 MLKIPFAVLG GCLLLAACGK SENTAEQPQN AAQSAPKPVFKVKYIDNTAI 51 AGLALGQSSE GKTNDGKKQI SYPIKGLPEQ NAVRLTGKHP NDLEAVVGKC 101METDGKDAPS GWAENGVCHT LFAKLVGNIA EDGGKLTDYL ISHSALQPYQ 151 AGKSGYAAVQNGRYVLEIDS EGAFThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 711>:

m205-1.seq.. 1 ATGCTGAAAA CATCTTTTGC CGTATTGGGC GGCTGCCTGC TGCTTGCCGC 51CTGCGGCAAA TCCGAAAATA CGGCGGAACA GCCGCAAAAC GCGGTACAAA 101 GCGCGCCGAAACCGGTTTTC AAAGTCAAAT ATATCGACAA TACGGCGATT 151 GCCGGTTTGG ATTTGGGACAAAGCAGCGAA GGCAAAACCA ACGACGGCAA 201 AAAACAAATC AGTTATCCGA TTAAAGGCTTGCCGGAACAA AATGTTATCC 251 GACTGATCGG CAAGCATCCC GGCGACTTGG AAGCCGTCAGCGGCAAATGT 301 ATGGAAACCG ATGATAAGGA CAGTCCGGCA GGTTGGGCAG AAAACGGCGT351 GTGCCATACC TTGTTTGCCA AACTGGTGGG CAATATCGCC GAAGACGGCG 401GCAAACTGAC GGATTACCTA GTTTCGCATG CCGCCCTGCA ACCCTATCAG 451 GCAGGCAAAAGCGGCTATGC CGCCGTGCAG AACGGACGCT ATGTGCTGGA 501 AATCGACAGC GAAGGGGCGTTTTATTTCCG CCGCCGCCAT TATTGAThis corresponds to the amino acid sequence <SEQ ID 712; ORF 205-1>:

m205-1.pep 1 MLKTSFAVLG GCLLLAACGK SENTAEQPQN AVQSAPKPVF KVKYIDNTAI 51AGLDLGQSSE GKTNDGKKQI SYPIKGLPEQ NVIRLIGKHP GDLEAVSGKC 101 METDDKDSPAGWAENGVCHT LFAKLVGNIA EDGGKLTDYL VSHAALQPYQ 151 AGKSGYAAVQ NGRYVLEIDSEGAFYFRRRH Y* m205-1/g205-1 92.0% identity in 174 aa overlap        10        20        30        40        50        60 g205-1.pepMLKIPFAVLGGCLLLAACGKSENTAEQPQNAAQSAPKPVFKVKYIDNTAIAGLALGQSSE|||  ||||||||||||||||||||||||||:||||||||||||||||||||| |||||| m205-1MLKTSFAVLGGCLLLAACGKSENTAEQPQNAVQSAPKPVFKVKYIDNTAIAGLDLGQSSE        10        20        30        40        50        60        70        80        90       100       110       120 g205-1.pepGKTNDGKKQISYPIKGLPEQNAVRLTGKHPNDLEAVVGKCMETDGKDAPSGWAENGVCHT|||||||||||||||||||||::|| ||||:||||| ||||||| ||:|:|||||||||| m205-1GKTNDGKKQISYPIKGLPEQNVIRLIGKHPGDLEAVSGKCMETDDKDSPAGWAENGVCHT        70        80        90       100       110       120       130       140       150       160       170 g205-1.pepLFAKLVGNIAEDGGKLTDYLISHSALQPYQAGKSGYAAVQNGRYVLEIDSEGAF||||||||||||||||||||:||:|||||||||||||||||||||||||||||| m205-1LFAKLVGNIAEDGGKLTDYLVSHAALQPYQAGKSGYAAVQNGRYVLEIDSEGAFYFRRRH       130       140       150       160       170       180 m205-1 YXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 713>:

a205-1.seq (partial) 1 CCTCTTAAAG GCTTGCCGGA ACAAAACGTC GTCCGGCTGACCGGCAAGCA 51 TCCCAACGAC TTGGAAGCCG TCGTCGGCAA ATGTATGGAA ACCGACGGAA 101AGGGCGCGCC TTCGGGCTGG GCGGCAAACG GCGTGTGCCA TACCTTGTTT 151 GCCAAACTGGTGGGCAATAT CGCCGAAGAC GGCGGCAAAC TGACGGATTA 201 CCTGATTTCG CATTCCGCCCTGCAACCCTA TCAGGCAGGC AAAAGCGGCT 251 ATGCCGCCGT GCAGAACGGA CGCTATGTGCTGGAAATCGA CAGCGAGGGG 301 GCGTTTTATT TCCGCCGCCG CCATTATTGAThis corresponds to the amino acid sequence <SEQ ID 714; ORF 205-1.a>:

a205-1.pep (partial) 1 PLKGLPEQNV VRLTGKHPND LEAVVGKCME TDGKGAPSGWAANGVCHTLF 51 AKLVGNIAED GGKLTDYLIS HSALQPYQAG KSGYAAVQNG RYVLEIDSEG 101AFYFRRRHY* m205-1/a205-1 89.0% identity in 109 aa overlap      50        60        70        80        90       100 m205-1.pepKYIDNTAIAGLDLGQSSEGKTNDGKKQISYPIKGLPEQNVIRLIGKHPGDLEAVSGKCME                              |:||||||||:|| ||||:||||| ||||| a205-1                              PLKGLPEQNVVRLTGKHPNDLEAVVGKCME                                      10        20        30     110       120       130       140       150       160 m205-1.pepTDDKDSPAGWAENGVCHTLFAKLVGNIAEDGGKLTDYLVSHAALQPYQAGKSGYAAVQNG|| | :|:||| ||||||||||||||||||||||||||:||:|||||||||||||||||| a205-1TDGKGAPSGWAANGVCHTLFAKLVGNIAEDGGKLTDYLISHSALQPYQAGKSGYAAVQNG        40        50        60        70        80        90     170       180 m205-1.pep RYVLEIDSEGAFYFRRRHYX ||||||||||||||||||||a205-1 RYVLEIDSEGAFYFRRRHYX        100       110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 715>:

g206.seq 1 atgttttccc ccgacaaaac ccttttcctc tgtctcggcg cactgctcct 51cgcctcatgc ggcacgacct ccggcaaaca ccgccaaccg aaacccaaac 101 agacagtccggcaaatccaa gccgtccgca tcagccacat cggccgcaca 151 caaggctcgc aggaactcatgctccacagc ctcggactca tcggcacgcc 201 ctacaaatgg ggcggcagca gcaccgcaaccggcttcgac tgcagcggca 251 tgattcaatt ggtttacaaa aacgccctca acgtcaagctgccgcgcacc 301 gcccgcgaca tggcggcggc aagccgcaaa atccccgaca gccgcctcaa351 ggccggcgac atcgtattct tcaacaccgg cggcgcacac cgctactcac 401acgtcggact ctacatcggc aacggcgaat tcatccatgc ccccggcagc 451 ggcaaaaccatcaaaaccga aaaactctcc acaccgtttt acgccaaaaa 501 ctaccttgga gcgcatacgttttttacaga atgaThis corresponds to the amino acid sequence <SEQ ID 716; ORF 206.ng>:

g206.pep 1 MFSPDKTLFL CLGALLLASC GTTSGKHRQP KPKQTVRQIQ AVRISHIGRT 51QGSQELMLHS LGLIGTPYKW GGSSTATGFD CSGMIQLVYK NALNVKLPRT 101 ARDMAAASRKIPDSRLKAGD IVFFNTGGAH RYSHVGLYIG NGEFIHAPGS 151 GKTIKTEKLS TPFYAKNYLGAHTFFTE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 717>:

m206.seq 1 ATGTTTCCCC CCGACAAAAC CCTTTTCCTC TGTCTCAGCG CACTGCTCCT 51CGCCTCATGC GGCACGACCT CCGGCAAACA CCGCCAACCG AAACCCAAAC 101 AGACAGTCCGGCAAATCCAA GCCGTCCGCA TCAGCCACAT CGACCGCACA 151 CAAGGCTCGC AGGAACTCATGCTCCACAGC CTCGGACTCA TCGGCACGCC 201 CTACAAATGG GGCGGCAGCA GCACCGCAACCGGCTTCGAT TGCAGCGGCA 251 TGATTCAATT CGTTTACAAr AACGCCCTCA ACGTCAAGCTGCCGCGCACC 301 GCCCGCGACA TGGCGGCGGC AAGCCGsAAA ATCCCCGAcA GCCGCyTCAA351 GGCCGGCGAC CTCGTATTCT TCAACACCGG CGGCGCACAC CGCTACTCAC 401ACGTCGGACT CTACATCGGC AACGGCGAAT TCATCCATGC CCCCAGCAGC 451 GGCAAAACCATCAAAACCGA AAAACTCTCC ACACCGTTTT ACGCCAAAAA 501 CTACCTCGGC GCACATACTTTTTTTACAGA ATGAThis corresponds to the amino acid sequence <SEQ ID 718; ORF 206>:

m206.pep.. 1 MFPPDKTLFL CLSALLLASC GTTSGKHRQP KPKQTVRQIQ AVRISHIDRT 51QGSQELMLHS LGLIGTPYKW GGSSTATGFD CSGMIQFVYK NALNVKLPRT 101 ARDMAAASRKIPDSRXKAGD LVFFNTGGAH RYSHVGLYIG NGEFIHAPSS 151 GKTIKTEKLS TPFYAKNYLGAHTFFTE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 206 shows 96.0% identity over a 177 aa overlap with a predicted ORF(ORF 206.ng) from N. gonorrhoeae:

m206/g206         10        20        30        40        50        60m206.pep MFPPDKTLFLCLSALLLASCGTTSGKHRQPKPKQTVRQIQAVRISHIDRTQGSQELMLHS|| |||||||||:|||||||||||||||||||||||||||||||||| |||||||||||| g206MFSPDKTLFLCLGALLLASCGTTSGKHRQPKPKQTVRQIQAVRISHIGRTQGSQELMLHS        10        20        30        40        50        60        70        80        90       100       110       120 m206.pepLGLIGTPYKWGGSSTATGFDCSGMIQFVYKNALNVKLPRTARDMAAASRKIPDSRXKAGD||||||||||||||||||||||||||:|||||||||||||||||||||||||||| |||| g206LGLIGTPYKWGGSSTATGFDCSGMIQLVYKNALNVKLPRTARDMAAASRKIPDSRLKAGD        70        80        90       100       110       120       130       140       150       160       170 m206.pepLVFFNTGGAHRYSHVGLYIGNGEFIHAPSSGKTIKTEKLSTPFYAKNYLGAHTFFTEX:|||||||||||||||||||||||||||:|||||||||||||||||||||||||||| g206IVFFNTGGAHRYSHVGLYIGNGEFIHAPGSGKTIKTEKLSTPFYAKNYLGAHTFFTE       130       140       150       160       170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 719>:

a206.seq 1 ATGTTTCCCC CCGACAAAAC CCTTTTCCTC TGTCTCAGCG CACTGCTCCT 51CGCCTCATGC GGCACGACCT CCGGCAAACA CCGCCAACCG AAACCCAAAC 101 AGACAGTCCGGCAAATCCAA GCCGTCCGCA TCAGCCACAT CGACCGCACA 151 CAAGGCTCGC AGGAACTCATGCTCCACAGC CTCGGACTCA TCGGCACGCC 201 CTACAAATGG GGCGGCAGCA GCACCGCAACCGGCTTCGAT TGCAGCGGCA 251 TGATTCAATT CGTTTACAAA AACGCCCTCA ACGTCAAGCTGCCGCGCACC 301 GCCCGCGACA TGGCGGCGGC AAGCCGCAAA ATCCCCGACA GCCGCCTTAA351 GGCCGGCGAC CTCGTATTCT TCAACACCGG CGGCGCACAC CGCTACTCAC 401ACGTCGGACT CTATATCGGC AACGGCGAAT TCATCCATGC CCCCAGCAGC 451 GGCAAAACCATCAAAACCGA AAAACTCTCC ACACCGTTTT ACGCCAAAAA 501 CTACCTCGGC GCACATACTTTCTTTACAGA ATGAThis corresponds to the amino acid sequence <SEQ ID 720; ORF 206.a>:

a206.pep 1 MFPPDKTLFL CLSALLLASC GTTSGKHRQP KPKQTVRQIQ AVRISHIDRT 51QGSQELMLHS LGLIGTPYKW GGSSTATGFD CSGMIQFVYK NALNVKLPRT 101 ARDMAAASRKIPDSRLKAGD LVFFNTGGAH RYSHVGLYIG NGEFIHAPSS 151 GKTIKTEKLS TPFYAKNYLGAHTFFTE* m206/a206 99.4% identity in 177 aa overlap        10        20        30        40        50        60 m206.pepMFPPDKTLFLCLSALLLASCGTTSGKHRQPKPKQTVRQIQAVRISHIDRTQGSQELMLHS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a206MFPPDKTLFLCLSALLLASCGTTSGKHRQPKPKQTVRQIQAVRISHIDRTQGSQELMLHS        10        20        30        40        50        60        70        80        90       100       110       120 m206.pepLGLIGTPYKWGGSSTATGFDCSGMIQFVYKNALNVKLPRTARDMAAASRKIPDSRXKAGD||||||||||||||||||||||||||||||||||||||||||||||||||||||| |||| a206LGLIGTPYKWGGSSTATGFDCSGMIQFVYKNALNVKLPRTARDMAAASRKIPDSRLKAGD        70        80        90       100       110       120       130       140       150       160       170 m206.pepLVFFNTGGAHRYSHVGLYIGNGEFIHAPSSGKTIKTEKLSTPFYAKNYLGAHTFFTEX|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a206LVFFNTGGAHRYSHVGLYIGNGEFIHAPSSGKTIKTEKLSTPFYAKNYLGAHTFFTEX       130       140       150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 721>:

g209.seq 1 atgctgcggc atttaggaaa cgacttcgcc ttgggcgcgt tgtttttcga 51tgctgcggtt gatgtgccac tgctgggcga tggtcaggag gttgttgacc 101 acccagtagagaaccaaacc ggcagggaag aagaagaaca tgacggagaa 151 aaccaacggc atgattttcatcattttcgc ctgcatcggg tcggtcggcg 201 gcgggttcag ataggtttgg gcgaacatcgttgccgccat aatgatgggc 251 aggatgtagt aggggtcggc gcggctgagg tcggtaatccagcccagcca 301 aggtgcctgg cgcaattcta cggaggcgaa caatgcccag tacaagccga351 tgaagacggg gatttgcaac agcataggca gacagccgcc cagcgggttg 401atttcctcgt cttcgaaaag ctgcatcatc gcttgctgtt gcgccatacg 451 gtcgtcgccgtatttttctt tgatggtctg cagttcgggt gcggcggcac 501 gcattttcgc catcgaacggtaggaggcgt tggtcaatgg atacagtacg 551 gctttgacga tgatggtcaa aacgacgattgcccagcccc agttgccgat 601 aatgttgtgc agttggttca ggagccagaa gagcggcgatgcgaaccagt 651 gtactttacc gtagtctttt gccagttgca ggttgtcggc gatgtttgcg701 ataacggatg tggtttgcgg accggcatac aggttgaccg ccattttcgg 751ttttggcccc cgggttggga tagcggttaaThis corresponds to the amino acid sequence <SEQ ID 722; ORF 209.ng>:

g209.pep 1 MLRHLGNDFA LGALFFDAAV DVPLLGDGQE VVDHPVENQT GREEEEHDGE 51NQRHDFHHFR LHRVGRRRVQ IGLGEHRCRH NDGQDVVGVG AAEVGNPAQP 101 RCLAQFYGGEQCPVQADEDG DLQQHRQTAA QRVDFLVFEK LHHRLLLRHT 151 VVAVFFFDGL QFGCGGTHFRHRTVGGVGQW IQYGFDDDGQ NDDCPAPVAD 201 NVVQLVQEPE ERRCEPVYFT VVFCQLQVVGDVCDNGCGLR TGIQVDRHFR 251 FWPPGWDSG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 723>:

m209.seq 1 ATGCTGCGGC ATTTAGGAAA CGACTTCGCC TTGGgGCGTT GTTTTTCGAT 51GCTGCGGTTG ATGTGCCATT GCTGGGCGAT GGTCAGGAGG TTGTTGACTA 101 CCCAGTACAATACCAGACCG GCAGGGAAGA AGAAGAACAT GACGGAGAAA 151 ACCAACGGCA TGATTTTCATCATTTTCGCC TGCATCGGGT CGGTCGGCGG 201 CGGGTTCAGA TAAGTTTGGG CGAACATCGTTGCCGCCATA ATGATGGGCA 251 GGATGTAGTA GGGGTCGGCG CGGCTGAGGT CGGTAATCCAACCCAGCCAA 301 GGTGCCTGGC GCAATTCTAC GGAGGCGAAC AATGCCCAAT ACAATCCGAT351 GAAGACGGGG ATTTGCAACA GCATAGGCAG GCAGCCGCCC AGCGGGTTGA 401TTTTCTCGTC TGTGTAAAGC TGCATCATCG CCTGTTGTTG CGCCATACGG 451 TCGTCGCCGTATTTCTCTTT GATGGCTTGC AGTTTGGGTG CGGCGGCACG 501 CATTTTCGCC ATAGAGCGGTAAGAGGCGTT GGTCAATGGA TACAGTACGG 551 CTTTGACGAT GATGGTTAAA ACGATAATCGCCCAGCCCCA GTTGCCGATG 601 ATGTTGTGCA GTTGGTTCAG GAGCCAGAAG AGCGGGGAGGCGAACCAGTG 651 TACTTTGCCG TAGTCTTTGG CCAGTTGCAG GTTGTCGGCG ATGTTTGCGA701 TGACGGATGT GGTCTGCGGG CCGGCGTAGA GGTTGATGGA GGCTTCGgTT 751TCGCGCCGTT TTGGATGGCG GCTAAAGGCA CGCTGACGCT GGTGCTGTAC 801 AGCTTGTCGTTGCGGCGTTT GATGTCGATG TTGCACTCGC CTGCGGCGCA 851 AACGCTTTGT CTGCCTTTAGGTTGGAGAAT CCAGGTGGAC ATGAAGTGGT 901 GTTCAATCAT GCCGAGCCAG CCGGTCGGGGTTTTGCGGAT GTATTCGGCC 951 TCGGATTTGC CGGATTTGGC ATCGTCGTCC AAGTCGGAAAAGCTGACTTT 1001 TTGGAAGTTG CCTTCAGGGG TATAAThis corresponds to the amino acid sequence <SEQ ID 724; ORF 209>:

m209.pep 1 MLRHLGNDFA LGALFFDAAV DVPLLGDGQE VVDYPVQYQT GREEEEHDGE 51NQRHDFHHFR LHRVGRRRVQ ISLGEHRCRH NDGQDVVGVG AAEVGNPTQP 101 RCLAQFYGGEQCPIQSDEDG DLQQHRQAAA QRVDFLVCVK LHHRLLLRHT 151 VVAVFLFDGL QFGCGGTHFRHRAVRGVGQW IQYGFDDDG* NDNRPAPVAD 201 DVVQLVQEPE ERGGEPVYFA VVFGQLQVVGDVCDDGCGLR AGVEVDGGFG 251 FAPFWMAAKG TLTLVLYSLS LRRLMSMLHS PAAQTLCLPLGWRIQVDMKW 301 CSIMPSQPVG VLRMYSASDL PDLASSSKSE KLTFWKLPSG V*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 209 shows 88.5% identity over a 253 aa overlap with a predicted ORF(ORF 209.ng) from N. gonorrhoeae:

m209/g209         10        20        30        40        50        60m209.pep MLRHLGNDFALGALFFDAAVDVPLLGDGQEVVDYPVQYQTGREEEEHDGENQRHDFHHFR|||||||||||||||||||||||||||||||||:||: |||||||||||||||||||||| g209MLRHLGNDFALGALFFDAAVDVPLLGDGQEVVDHPVENQTGREEEEHDGENQRHDFHHFR        10        20        30        40        50        60        70        80        90       100       110       120 m209.pepLHRVGRRRVQISLGEHRCRHNDGQDVVGVGAAEVGNPTQPRCLAQFYGGEQCPIQSDEDG|||||||||||:|||||||||||||||||||||||||:|||||||||||||||:|:|||| g209LHRVGRRRVQIGLGEHRCRHNDGQDVVGVGAAEVGNPAQPRCLAQFYGGEQCPVQADEDG        70        80        90       100       110       120       130       140       150       160       170       180 m209.pepDLQQHRQAAAQRVDFLVCVKLHHRLLLRHTVVAVFLFDGLQFGCGGTHFRHRAVRGVGQW|||||||:|||||||||  ||||||||||||||||:||||||||||||||||:| ||||| g209DLQQHRQTAAQRVDFLVFEKLHHRLLLRHTVVAVFFFDGLQFGCGGTHFRHRTVGGVGQW       130       140       150       160       170       180       190       200       210       220       230       240 m209.pepIQYGFDDDGXNDNRPAPVADDVVQLVQEPEERGGEPVYFAVVFGQLQVVGDVCDDGCGLR||||||||| ||: ||||||:|||||||||||  |||||:||| ||||||||||:||||| g209IQYGFDDDGQNDDCPAPVADNVVQLVQEPEERRCEPVYFTVVFCQLQVVGDVCDNGCGLR       190       200       210       220       230       240       250        260       270       280       290      299 m209.pepAGVEVDGGFGF-APFWMAAKGTLTLVLYSLSLRRLMSMLHSPAAQTLCLPLGWRIQVDMK:|::||  | |  | | g209 TGIQVDRHFRFWPPGWDSG        250The following partial DNA sequence was identified in N. meningitidis<SEQ ID 725>:

a209.seq 1 ATGCTGCGGC ATTTAGGAAA CGACTTCGCC TTGGGCGCGT TGTTTTTCGA 51TGCTGCGGTT GATGTGCCAT TGCTGGGCGA TGGTCAGGAG GTTGTTGATC 101 ACCCAGTACAATACCAGACC GGCAGGGAAG AAGAAGAACA TGACGGAGAA 151 AACCAAAGGC ATGATTTTCATCATTTTCGC CTGCATCGGG TCGGTCGGCG 201 GCGGGTTCAG ATAGGTTTGG GCGAACATCGTTGCCGCCAT AATGATGGGC 251 AGGATGTAGT AGGGGTCGGC GCGGCTGAGG TCGGTAATCCAACCCAGCCA 301 AGGTGCCTGG CGCAATTCTA CGGAGGCGAA CAATGCCCAA TACAATCCGA351 TGAAGACGGG GATTTGCAAC AGCATAGGCA GGCAGCCGCC CAGCGGGTTG 401ATTTTCTCGT CTGTGTAAAG CTGCATCATG GCTTGTTGCT GCGCCATACG 451 GTCGTCGCCGTATTTCTCTT TGATGGCTTG CAGTTTGGGC GCGGCGGCAC 501 GCATTTTCGC CATCGAACGGTAAGAGGCGT TGGTCAATGG ATACAGTACG 551 GCTTTGACGA TGATGGTTAA AACGATAATCGCCCAGCCCC AGTTGCCGAT 601 GATGTTGTGC AGTTGGTTCA AAAGCCAAAA GAGGGGGGAGGCGAACCAGT 651 GTACTTTGCC GTAGTCTTTG GCCAGTTGCA GGTTGTCGGC GATGTTTGCG701 ATAACGGATG TGGTCTGTGG GCCGGCGTAG AGGTTGATGG AGGCTTCGGT 751TTCGCACCGT TTTGGATAGC GGCTAAAGGC ACGCTGACGC TGGTGCTGTA 801 CAGCTTGTCGTTGCGGCGTT TGATGTCGAT ACGGCAGTCG CCAGCGGCGC 851 AAACGCTTTG TCCGCCTTTGGGTTGGAGGA TCCAGGTGGA CATGAAGTGG 901 TGTTCAATCA TGCCGAGCCA GCCGGTCGGGGTTTTGCGGA TGTATTCGGC 951 CTCGGATTTG CCGGATTTGG CATCGTCGTC CAAGTCGGAGAAGCTGACTT 1001 TTTGGAAGTT GCCTTCAGGG GTATAAThis corresponds to the amino acid sequence <SEQ ID 726; ORF 209.a>:

a209.pep 1 MLRHLGNDFA LGALFFDAAV DVPLLGDGQE VVDHPVQYQT GREEEEHDGE 51NQRHDFHHFR LHRVGRRRVQ IGLGEHRCRH NDGQDVVGVG AAEVGNPTQP 101 RCLAQFYGGEQCPIQSDEDG DLQQHRQAAA QRVDFLVCVK LHHGLLLRHT 151 VVAVFLFDGL QFGRGGTHFRHRTVRGVGQW IQYGFDDDG* NDNRPAPVAD 201 DVVQLVQKPK EGGGEPVYFA VVFGQLQVVGDVCDNGCGLW AGVEVDGGFG 251 FAPFWIAAKG TLTLVLYSLS LRRLMSIRQS PAAQTLCPPLGWRIQVDMKW 301 CSIMPSQPVG VLRMYSASDL PDLASSSKSE KLTFWKLPSG V* m209/a20995.6% identity in 341 aa overlap        10        20        30        40        50        60 m209.pepMLRHLGNDFALGALFFDAAVDVPLLGDGQEVVDYPVQYQTGREEEEHDGENQRHDFHHFR|||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||| a209MLRHLGNDFALGALFFDAAVDVPLLGDGQEVVDHPVQYQTGREEEEHDGENQRHDFHHFR        10        20        30        40        50        60        70        80        90       100       110       120 m209.pepLHRVGRRRVQISLGEHRCRHNDGQDVVGVGAAEVGNPTQPRCLAQFYGGEQCPIQSDEDG|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||| a209LHRVGRRRVQIGLGEHRCRHNDGQDVVGVGAAEVGNPTQPRCLAQFYGGEQCPIQSDEDG        70        80        90       100       110       120       130       140       150       160       170       180 m209.pepDLQQHRQAAAQRVDFLVCVKLHHRLLLRHTVVAVFLFDGLQFGCGGTHFRHRAVRGVGQW||||||||||||||||||||||| ||||||||||||||||||| ||||||||:||||||| a209DLQQHRQAAAQRVDFLVCVKLHHGLLLRHTVVAVFLFDGLQFGRGGTHFRHRTVRGVGQW       130       140       150       160       170       180       190       200       210       220       230       240 m209.pepIQYGFDDDGXNDNRPAPVADDVVQLVQEPEERGGEPVYFAVVFGQLQVVGDVCDDGCGLR|||||||||||||||||||||||||||:|:| ||||||||||||||||||||||:|||| a209IQYGFDDDGXNDNRPAPVADDVVQLVQKPKEGGGEPVYFAVVFGQLQVVGDVCDNGCGLW       190       200       210       220       230       240       250       260       270       280       290       300 m209.pepAGVEVDGGFGFAPFWMAAKGTLTLVLYSLSLRRLMSMLHSPAAQTLCLPLGWRIQVDMKW|||||||||||||||:||||||||||||||||||||: :|||||||| |||||||||||| a209AGVEVDGGFGFAPFWIAAKGTLTLVLYSLSLRRLMSIRQSPAAQTLCPPLGWRIQVDMKW       250       260       270       280       290       300       310       320       330       340 m209.pepCSIMPSQPVGVLRMYSASDLPDLASSSKSEKLTFWKLPSGVX|||||||||||||||||||||||||||||||||||||||||| a209CSIMPSQPVGVLRMYSASDLPDLASSSKSEKLTFWKLPSGVX       310       320       330       340The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 727>:

g211.seq 1 atgttgcgga ttgctgctgc caatcagttg ggcggtcgaa atggtgcggc 51ggtgggaaac ggggtcgata agtttgggcg tggtgctgat aatcaggttg 101 agtttttggaaggaaacctg attgtagtcg gcgcgtccgg gcgtgccgct 151 gtaacggtag ccgtggcgcaattcgagcgt gcgtttgttg tccttcagcg 201 agaagttacc ttctttggcg aagatgatgttgtcgccgcc gtttttgtcc 251 tgttcgcgca ggaacaggtt tttcatgatg ccggattcggtgtcaaaggt 301 ttcgacgaaa taaaccctgc cgttgcgctt gcccaagtta ttgaactcgc351 cggcttccac caaagacaat tcctgcttct gcttcaaaat ttcggcatat 401tcgcggctgc gcagctctgc ccacggtatc acccaaagct gcatgacggc 451 aatcaggatggcaaacggca cggcaaactg catgacgggg cgtatccact 501 gtttcaacgc caatccgcaggatagThis corresponds to the amino acid sequence <SEQ ID 728; ORF 211.ng>:

g211.pep 1 MLRIAAANQL GGRNGAAVGN GVDKFGRGAD NQVEFLEGNL IVVGASGRAA 51VTVAVAQFER AFVVLQREVT FFGEDDVVAA VFVLFAQEQV FHDAGFGVKG 101 FDEINPAVALAQVIELAGFH QRQFLLLLQN FGIFAAAQLC PRYHPKLHDG 151 NQDGKRHGKL HDGAYPLFQRQSAG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 729>:

m211.seq 1 ATGTTGCGGG TTGCTGCTGC CAATCAGTTG GGCGGTCGGA ATGGTACGGC 51GGTGGGAAAC GGGGTCGATG AGTTTGGGCG TGGTGCTGAT AATCAGGTTG 101 AGTTTTTGGAAGGAAACCTG ATTGTAGTCG GCGCGTCCGG GCGTGCCGCT 151 GTAACGGTAG CCGTGGCGCAATTCGAGCGT GCGTTTGTTG TCGTTCAGCG 201 AGAAGTTACC TTCTTTGGCG AAGATGATGTTGTCGCCGCC GTTTTTGTCC 251 TGTTCGCGCA GGAACAGGTT TTTCATGATG CCGGATTCGGTATCGAAGGT 301 TTCGACAAAA TAAACCCTGC CGTTGCGCTT GCCCAAACTG TTGAACTCGC351 CTGCCTCCAC CAAAGACAAT TCCTGCTTCT GCTTCAGGAT TTCAGCGTAT 401TCGCGGCTGC GTAGCTCTGC CCACGGTATC ACCCAAAGCT GCATGACGGC 451 AACCAAAACGGCAAACGGCA CGGCAAACTG CATCACCGGG CGTATCCATT 501 GTTTCAATGC CAATCCGCAgGATAGThis corresponds to the amino acid sequence <SEQ ID 730; ORF 211>:

m211.pep 1 MLRVAAANQL GGRNGTAVGN GVDEFGRGAD NQVEFLEGNL IVVGASGRAA 51VTVAVAQFER AFVVVQREVT FFGEDDVVAA VFVLFAQEQV FHDAGFGIEG 101 FDKINPAVALAQTVELACLH QRQFLLLLQD FSVFAAAXLC PRYHPKLHDG 151 NQNGKRHGKL HHRAYPLFQCQSAG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 211 shows 89.1% identity over a 174 aa overlap with a predicted ORF(ORF 211.ng) from N. gonorrhoeae:

m211/g211         10        20        30        40        50        60m211.pep MLRVAAANQLGGRNGTAVGNGVDEFGRGADNQVEFLEGNLIVVGASGRAAVTVAVAQFER|||:|||||||||||:|||||||:|||||||||||||||||||||||||||||||||||| g211MLRIAAANQLGGRNGAAVGNGVDKFGRGADNQVEFLEGNLIWGASGRAAVTVAVAQFER        10        20        30        40        50        60        70        80        90       100       110       120 m211.pepAFVVVQREVTFFGEDDVVAAVFVLFAQEQVFHDAGFGIEGFDKINPAVALAQTVELACLH||||:||||||||||||||||||||||||||||||||::|||:|||||||||::||| :| g211AFVVLQREVIFFGEDDVVAAVFVLFAQEQVFHDAGFGVKGFDEINPAVALAQVIELAGFH        70        80        90       100       110       120       130       140       150       160       170 m211.pepQRQFLLLLQDFSVFAAAXLCPRYHPKLHDGNQNGKRHGKLHHRAYPLFQCQSAGX|||||||||:|::|||| ||||||||||||||:||||||||  |||||| |||| g211QRQFLLLLQNFGIFAAAQLCPRYHPKLHDGNQDGKRHGKLHDGAYPLFQRQSAG       130       140       150       160       170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 731>:

a211.seq 1 ATGTTGCGGG TTGCTGCTGC CAATCAGTTG GGCGGTCGGA ATGGTACGGC 51GGTGGGAAAC GGGGTCGATG AGTTTGGGCG TGGTGCTGAT AATCAGGTTG 101 AGTTTTTGGAAGGAAACCTG ATTGTAGTCG GCGCGTCCGG GCGTGCCGCT 151 GTAACGGTAG CCGTGGCGCAATTCGAGCGT GCGTTTGTTG TCGTTCAGCG 201 AGAAGTTACT TTCTTTGGCG AAGATGATGTTGTCGCCGCC GTTTTTGTCC 251 TGTTCGCGCA GGAACAGGTT TTTCATGATG CCGGATTCGGTATCGAAGGT 301 TTCGACAAAA TAAACCCTGC CGTTGCGCTT GCCCAAACTG TTGAACCCGC351 CTGCCTCCAC CAAAGACAAT TCCTGCTTCT GCTTCAGGAT TTCAGCGTAT 401TCGCGGCTGC GTAGCTCTGC CCACGGTATC ACCCAAAGCT GCATGACGGC 451 AACCAAAACGGCAAACGGCA CGGCAAACTG CATCACCGGG CGTATCCATT 501 GTTTCAATGC CAATCCGCAGGATAGThis corresponds to the amino acid sequence <SEQ ID 732; ORF 211.a>:

a211.pep 1 MLRVAAANQL GGRNGTAVGN GVDEFGRGAD NQVEFLEGNL IVVGASGRAA 51VTVAVAQFER AFVVVQREVT FFGEDDVVAA VFVLFAQEQV FHDAGFGIEG 101 FDKINPAVALAQTVEPACLH QRQFLLLLQD FSVFAAA*LC PRYHPKLHDG 151 NQNGKRHGKL HHRAYPLFQCQSAG* m211/a211 99.4% identity in 174 aa overlap        10        20        30        40        50        60 m211.pepMLRVAAANQLGGRNGTAVGNGVDEFGRGADNQVEFLEGNLIVVGASGRAAVTVAVAQFER|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a211MLRVAAANQLGGRNGTAVGNGVDEFGRGADNQVEFLEGNLIVVGASGRAAVTVAVAQFER        10        20        30        40        50        60        70        80        90       100       110       120 m211.pepAFVVVQREVTFFGEDDVVAAVFVLFAQEQVFHDAGFGIEGFDKINPAVALAQTVELACLH||||||||||||||||||||||||||||||||||||||||||||||||||||||| |||| a211AFVVVQREVTFFGEDDVVAAVFVLFAQEQVFHDAGFGIEGFDKINPAVALAQTVEPACLH        70        80        90       100       110       120       130       140       150       160       170 m211.pepQRQFLLLLQDFSVFAAAXLCPRYHPKLHDGNQNGKRHGKLHHRAYPLFQCQSAGX||||||||||||||||||||||||||||||||||||||||||||||||||||||| a211QRQFLLLLQDFSVFAAAXLCPRYHPKLHDGNQNGKRHGKLHHRAYPLFQCQSAGX       130       140       150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 733>:

g212.seq (partial) 1 atggacaatc tcgtatggga cggcattccc gacatccgcacactcgacca 51 aaccatccgc aaacacgcac acccgctcaa cctgattgtc tgcctccccg 101ataatcagat tcccgatttt caaaccgcac aagatgcttc ggactcggaa 151 tgccgtctgaagcaccgttt ggatcaggca acccagtgcc tccagttcga 201 cagcatcaac ctcatcgaacacatcctgcc cgatgtccgc ttctggctgg 251 ttcccccttc acgcacccgc cgcctgcacgaacacttcca ccacatttcc 301 tggcagaccg aagccatccc gcaaaccgaa agcaagtccgacaaaccctg 351 gtttgcactt ccacaaacat ccgaacggaa aaaaccggaa cacgtcctcg401 tcatcggtgc aggcattgcc ggcgcatcga ccgcccacgc cttagcatca 451cacggcattt ccgttaccgt attggaagcc cgaaaagccg ctcaagccgc 501 cagcggcaaccggcaagggc tgctttacgc caaaatctcg ccgcacgaca 551 ccggacagac cgaactgctgcttgccggct acggctacac caaacgcctg 601 ctcggacaca tcctgcccga ctccgacacttggggcggca acggcatcat 651 ccacctcaat tacagccgca ccgaacaaca acgcaatcacgaattgggtt 701 tgcaaaaaca ccataaccac ctctaccgca gcatcacgtc tgcagaagcc751 gaaaaaatcg ccggcatccc gctgaacacg ccctacgccg aaccattatg 801cggactctac tggcaacacg gcgtatggct caatccgccc gcattcgtcc 851 gcaccctcctcagccatccg ctgatcgaac tatatgaaaa cacaacgtta 901 accggcattt cccacgacggagaaaagtgg attgcaagca cgccaaacgg 951 cacatttacc gccacacaca tcatctactgcaccggcgcg cacagcccct 1001 gcctgcccga aaccaacctc gccgccctac ccctcaggcaaatacgcgga 1051 caaaccggcc tcacaccgtc caccccgttt tccgaacaac tgcgttgcgc1101 cgtttcaggc gaaagctaca tcagcccgtc gtggcacgga ctgcactgct 1151acggcgcgag ttttattccc aacagcagca ataccggatg gaacgaagcc 1201 gaagaagcctcaaaccgcca agcattggca caccttaacc ccgcccttgc 1251 cgaatcattg ttt...This corresponds to the amino acid sequence <SEQ ID 734; ORF 212.ng>:

g212.pep (partial) 1 MDNLVWDGIP DIRTLDQTIR KHAHPLNLIV CLPDNQIPDFQTAQDASDSE 51 CRLKHRLDQA TQCLQFDSIN LIEHILPDVR FWLVPPSRTR RLHEHFHHIS 101WQTEAIPQTE SKSDKPWFAL PQTSERKKPE HVLVIGAGIA GASTAHALAS 151 HGISVTVLEARKAAQAASGN RQGLLYAKIS PHDTGQTELL LAGYGYTKRL 201 LGHILPDSDT WGGNGIIHLNYSRTEQQRNH ELGLQKHHNH LYRSITSAEA 251 EKIAGIPLNT PYAEPLCGLY WQHGVWLNPPAFVRTLLSHP LIELYENTTL 301 TGISHDGEKW IASTPNGTFT ATHIIYCTGA HSPCLPETNLAALPLRQIRG 351 QTGLTPSTPF SEQLRCAVSG ESYISPSWHG LHCYGASFIP NSSNTGWNEA401 EEASNRQALA HLNPALAESL F...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 735>:

m212.seq 1 ATGGACAATC TCGTATGGGA CGGCATTCCC GACATCCGCA CACTCGACCA 51AGCCATCCGC AAACACGCAC CCCCGCTCAA CCTGATTATC TGCCTCCCCG 101 ATAATCAGATTCCCGATTTT CAAACCGCAC AAGATGCTTC GGACGCGGAA 151 TGCCGTCTGA AGCACCGTTTGGATCAGGCA ATGCAGTGCC TCCAGTTCGA 201 CAGCATCAAC CTCATCGAAC ACATCCTGCCCGATGTCCGC TTCTGGCTGG 251 TTCCCCCTTC ACGCACCCAC CACCTGCACG AACATTTCCACCACATTTCC 301 TGGCAGACCG AAGCCATCCC GCAAACCGAA AGCAAGCCCG ACAAACCCTG351 GTTTGCACTT CCACAAACAT CCGAACGGCA AAAACCGGAA CACATCCTCG 401TTATCGGCGC GGGCATATCC GGCGCGGCAA CCGCCCACGC CTTAGCATCA 451 CACGGCATTTCCGTTACCGT ATTGGAAGCC CGAAAAGCCG CCCAAGCCGC 501 CAGCGGCAAC CGCCAAGGGCTGCTCTACGC CAAAATCTCG CCGCACGACA 551 CCGAACAGAC CGAACTTTTG CTTGCCGGCTACGGCTACAC CAAACGCCTG 601 CTCGGACACA TCCTGCCCGA ATCCGAAACC TGGGGCGGCAACGGCATCAT 651 CCACCTCAAT TACAGCCGCA CCGAACAACA ACGCAATCAC GAATTGGGTT701 TGCAAAAACA CCATAACCAC CTCTACCGCA GCATCACATC TGCAGAAGCC 751GAAAAAATCG CCGGTATCCC ACTGTCCGTC CCATACGACC ACCCTTCATG 801 CGGACTCTACTGGCAACACG GCGTATGGCT CAATCCACCC GCATTCGTCC 851 GCACCCTCCT CAACCATCCGCTCATTGGAC TACACGAAGA CACACCCTTG 901 ACCGACATTT CCCACGACGG GGaAAAGTGGATTGCAAGCA CGCCAAACGG 951 CACATTTACC GCCACACACA TCATCTACTG CACCGGTGCGAACAGCCCCT 1001 ACCTACCCGA AACCAACCTC GCCGCCCTGC CTCTCAGGCA AATACGCGGA1051 CAAACCGGCC TCACACCGTC CACCCCGTTT TCCGAACAAC TGCGTTGCGC 1101CGTTTCAGGC GAAAGCTACA TCAGCCCGTC GTGGCACGGA CTGCACTGCT 1151 ACGGCGCGAGTTTTATTCCC AACAGCAGCC ATACCGGATG GAACGAAGCC 1201 GAAGAAGCCT CAAACCGCCAAGCATTGGCA CACCTTAACC CCGCCCTTTC 1251 CGAATCATTG TTTGCCGCCA ACCCAAACCCCCAAAAACAC CAAGGGCACG 1301 CCGCCATACG CTGCGACAGC CCCGACCACC TTCCCCTAGTCGGCGCACTC 1351 GGCGACATTG CCGCCATGCG GCAGACCTAC ACCAAACTCG CGCTGGACAA1401 AAACTACCGC ATCGACACCC CATGCCCATA CCTGCCTAAT GCCTACGTCA 1451ACACCGCGCA CGGCACCCGC GGACTCGCCA CCGCCCCCAT CTGCGCCGCC 1501 GmCAwTGCAGCCCAAATCsT AGGCyTGCCC CATCCCTTTT yAcAAcGCCT 1551 gCGCCACGCC cTAcACCCCAACCGCACCAT CATCCGCGCC ATCGTCAGAA 1601 GGAAGGATCT AACCCCTTAAThis corresponds to the amino acid sequence <SEQ ID 736; ORF 212>:

m212.pep 1 MDNLVWDGIP DIRTLDQAIR KHAPPLNLII CLPDNQIPDF QTAQDASDAE 51CRLKHRLDQA MQCLQFDSIN LIEHILPDVR FWLVPPSRTH HLHEHFHHIS 101 WQTEAIPQTESKPDKPWFAL PQTSERQKPE HILVIGAGIS GAATAHALAS 151 HGISVTVLEA RKAAQAASGNRQGLLYAKIS PHDTEQTELL LAGYGYTKRL 201 LGHILPESET WGGNGIIHLN YSRTEQQRNHELGLQKHHNH LYRSITSAEA 251 EKIAGIPLSV PYDHPSCGLY WQHGVWLNPP AFVRTLLNHPLIGLHEDTPL 301 TDISHDGEKW IASTPNGTFT ATHIIYCTGA NSPYLPETNL AALPLRQIRG351 QTGLTPSTPF SEQLRCAVSG ESYISPSWHG LHCYGASFIP NSSHTGWNEA 401EEASNRQALA HLNPALSESL FAANPNPQKH QGHAAIRCDS PDHLPLVGAL 451 GDIAAMRQTYTKLALDKNYR IDTPCPYLPN AYVNTAHGTR GLATAPICAA 501 XXAAQIXGLP HPFXQRLRHALHPNRTIIRA IVRRKDLTP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 212 shows 92.9% identity over a 421 aa overlap with a predicted ORF(ORF 212.ng) from N. gonorrhoeae:

m212/g212         10        20        30        40        50        60m212.pep MDNLVWDGIPDIRTLDQAIRKHAPPLNLIICLPDNQIPDFQTAQDASDAECRLKHRLDQA|||||||||||||||||:||||| |||||:||||||||||||||||||:||||||||||| g212MDNLVWDGIPDIRTLDQTIRKHAHPLNLIVCLPDNQIPDFQTAQDASDSECRLKHRLDQA        10        20        30        40        50        60        70        80        90       100       110       120 m212.pepMQCLQFDSINLIEHILPDVRFWLVPPSRTHHLHEHFHHISWQTEAIPQTESKPDKPWFAL ||||||||||||||||||||||||||||::||||||||||||||||||||| ||||||| g212TQCLQFDSINLIEHILPDVRFWLVPPSRTRRLHEHFHHISWQTEAIPQTESKSDKPWFAL        70        80        90       100       110       120       130       140       150       160       170       180 m212.pepPQTSERQKPEHILVIGAGISGAATAHALASHGISVTVLEARKAAQAASGNRQGLLYAKIS||||||:||||:|||||||:||:||||||||||||||||||||||||||||||||||||| g212PQTSERKKPEHVLVIGAGIAGASTAHALASHGISVTVLEARKAAQAASGNRQGLLYAKIS       130       140       150       160       170       180       190       200       210       220       230       240 m212.pepPHDTEQTELLLAGYGYTKRLLGHILPESETWGGNGIIHLNYSRTEQQRNHELGLQKHHNH|||| |||||||||||||||||||||:|:||||||||||||||||||||||||||||||| g212PHDTGQTELLLAGYGYTKRLLGHILPDSDTWGGNGIIHLNYSRTEQQRNHELGLQKHHNH       190       200       210       220       230       240       250       260       270       280       290       300 m212.pepLYRSITSAEAEKIAGIPLSVPYDHPSCGLYWQHGVWLNPPAFVRTLLNHPLIGLHEDTPL||||||||||||||||||::|| :| |||||||||||||||||||||:|||| |:|:| | g212LYRSITSAEAEKIAGIPLNTPYAEPLCGLYWQHGVWLNPPAFVRTLLSHPLIELYENTTL       250       260       270       280       290       300       310       320       330       340       350       360 m212.pepTDISHDGEKWIASTPNGTFTATHIIYCTGANSPYLPETNLAALPLRQIRGQTGLTPSTPF| ||||||||||||||||||||||||||||:|| |||||||||||||||||||||||||| g212TGISHDGEKWIASTPNGTFTATHIIYCTGAHSPCLPETNLAALPLRQIRGQTGLTPSTPF       310       320       330       340       350       360       370       380       390       400       410       420 m212.pepSEQLRCAVSGESYISPSWHGLHCYGASFIPNSSHTGWNEAEEASNRQALAHLNPALSESL|||||||||||||||||||||||||||||||||:||||||||||||||||||||||:||| g212SEQLRCAVSGESYISPSWHGLHCYGASFIPNSSNTGWNEAEEASNRQALAHLNPALAESL       370       380       390       400       410       420       430       440       450       460       470       480 m212.pepFAANPNPQKHQGHAAIRCDSPDHLPLVGALGDIAAMRQTYTKLALDKNYRIDTPCPYLPN | g212 FThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 737>:

a212.seq 1 ATGGACAATC TCGCATGGAA CGGCATTCCC GACATCCGCA CACTCGACCA 51AACCATCCGC AAACACGCAC ACCCGCTCAA CCTGATTGTC TGCCTCCCCG 101 ATAATCAGATTCCCAATTTT CAAACCGCAC AAGATGCTTC GGACGCGGAA 151 TGCCGTCTGA AGCACCGTTTGGATCAGGCA ACCCAGTGCC TCCAGTTCGA 201 CAGCATCAAC CTGATTGAAC ACATCCTGCCCGATGTCCGC TTCTGGCTGG 251 TTCCCCCTTC ACGCACCCGC CGCCTGCACG AACACTTCCACCACATTTCC 301 TGGCAGACCG AAGCCATCCC GCAAACCGAA AGTAAGCCCG ACAAACCCTG351 GTTTGCACTT CCACAAACAT CCGAACGGCA AAAACCGGAA CACATCCTCG 401TTATCGGAGC GGGCATATCC GGCGCGGCAA CCGCCCACGC CTTAGCATCA 451 TACGGCATTTCCGTTACCGT ATTGGAAGCC CGAAAAGCCG CCCAAGCCGC 501 CAGCGGCAAC CGCCAAGGGCTGCTCTACGC CAAAATCTCG CCGCACGACA 551 CCGAACAAAC CGAACTGCTG CTTGCCGGCTACGGCTACAC CAAACGCCTG 601 CTCGGACATA TCCTGCCCGA ATCCGAAACC TGGGGCGGCAACGGCATCAT 651 CCACCTCAAT TACAGCCGCA CCGAACAACA ACGCAATCAC GAATTGGGTT701 TGCAAAAACA CCATAACCAC CTCTACCGCA GCATCACGCA GGCAGAAGCC 751GAAAAAATCG CCGGCATCCC TCTGAACACG CCCTACGCCG AACCATTATG 801 CGGACTGTTTTGGCAGTACG GCGTATGGCT CAATCCTCCC ACATTCGTCC 851 GCGCCCTCCT CAGCCATCCGCTCATTGGAC TACACGAAGA CACACCGTTA 901 ACCGACATTT CCCACGACGG GGAAAAGTGGATTGCAAGCA CGCCAAACGG 951 CACATTTACC GCCACACACA TCATCTACTG CACCGGTGCGAACAGCCCCT 1001 ACCTACCCGA AACCAACCTC GCCACCCTGC CCCTCAGGCA AATACGCGGA1051 CAAACCGGCC TCACACCGTC CACCCCGTTT TCCGAACAAC TGCGTTGCGC 1101CGTTTCAGGC GAAAGCTACA TCAGCCCGTC GTGGCACGGA CTGCACTGCT 1151 ACGGCGCGAGTTTTATTCCC AACAGCAGCC ATACCGGATG GAACGAAGCC 1201 GAAGAAGCCT CAAACCGCCAAGCATTGGCA CACCTTAACC CCGCCCTTTC 1251 CGAATCATTG TTTGCCGCCA ACCCAAACCCCCAAAAACAC CAAGGGCACG 1301 CCGCCATACG CTGCGACAGC CCCGACCACC TTCCCCTAGTCGGCGCACTC 1351 GGCGACATTG CCGCTATGCA ACAAACTTAC GCCAAACTCG CGCTGGACAA1401 AAACTATCGC ATCGATGCCC CCTGCCCGTA CCTGCCCAAT GCCTACGCCA 1451ACACCGCCCA CGGCACACGC GGGCTTGCCA CCGCCCCCAT CTGCGCCGCC 1501 GCCGTTGCAGCCGAAATCCT AGGCTTGCCC CATCCCCTCT CAAAACGCCT 1551 GCGCCACGCC CTACACCCCAACCGCGCCAT CATCCGCGCC ATCGTCAGAA 1601 GGAAGGATCT AACCCCTTAAThis corresponds to the amino acid sequence <SEQ ID 738; ORF 212.a>:

a212.pep 1 MDNLAWNGIP DIRTLDQTIR KHAHPLNLIV CLPDNQIPNF QTAQDASDAE 51CRLKHRLDQA TQCLQFDSIN LIEHILPDVR FWLVPPSRTR RLHEHFHHIS 101 WQTEAIPQTESKPDKPWFAL PQTSERQKPE HILVIGAGIS GAATAHALAS 151 YGISVTVLEA RKAAQAASGNRQGLLYAKIS PHDTEQTELL LAGYGYTKRL 201 LGHILPESET WGGNGIIHLN YSRTEQQRNHELGLQKHHNH LYRSITQAEA 251 EKIAGIPLNT PYAEPLCGLF WQYGVWLNPP TFVRALLSHPLIGLHEDTPL 301 TDISHDGEKW IASTPNGTFT ATHIIYCTGA NSPYLPETNL ATLPLRQIRG351 QTGLTPSTPF SEQLRCAVSG ESYISPSWHG LHCYGASFIP NSSHTGWNEA 401EEASNRQALA HLNPALSESL FAANPNPQKH QGHAAIRCDS PDHLPLVGAL 451 GDIAAMQQTYAKLALDKNYR IDAPCPYLPN AYANTAHGTR GLATAPICAA 501 AVAAEILGLP HPLSKRLRHALHPNRAIIRA IVRRKDLTP* m212/a212 93.7% identity in 539 aa overlap        10        20        30        40        50        60 m212.pepMDNLVWDGIPDIRTLDQAIRKHAPPLNLIICLPDNQIPDFQTAQDASDAECRLKHRLDQA||||:|:||||||||||:||||| |||||:||||||||:||||||||||||||||||||| a212MDNLAWNGIPDIRTLDQTIRKHAHPLNLIVCLPDNQIPNFQTAQDASDAECRLKHRLDQA        10        20        30        40        50        60        70        80        90       100       110       120 m212.pepMQCLQFDSINLIEHILPDVRFWLVPPSRTHHLHEHFHHISWQTEAIPQTESKPDKPWFAL ||||||||||||||||||||||||||||::||||||||||||||||||||||||||||| a212TQCLQFDSINLIEHILPDVRFWLVPPSRTRRLHEHFHHISWQTEAIPQTESKPDKPWFAL        70        80        90       100       110       120       130       140       150       160       170       180 m212.pepPQTSERQKPEHILVIGAGISGAATAHALASHGISVTVLEARKAAQAASGNRQGLLYAKIS||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||| a212PQTSERQKPEHILVIGAGISGAATAHALASYGISVTVLEARKAAQAASGNRQGLLYAKIS       130       140       150       160       170       180       190       200       210       220       230       240 m212.pepPHDTEQTELLLAGYGYTKRLLGHILPESETWGGNGIIHLNYSRTEQQRNHELGLQKHHNH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a212PHDTEQTELLLAGYGYTKRLLGHILPESETWGGNGIIHLNYSRTEQQRNHELGLQKHHNH       190       200       210       220       230       240       250       260       270       280       290       300 m212.pepLYRSITSAEAEKIAGIPLSVPYDHPSCGLYWQHGVWLNPPAFVRTLLNHPLIGLHEDTPL||||||:|||||||||||::|| :| |||:||:|||||||:|||:||:|||||||||||| a212LYRSITQAEAEKIAGIPLNTPYAEPLCGLFWQYGVWLNPPTFVRALLSHPLIGLHEDTPL       250       260       270       280       290       300       310       320       330       340       350       360 m212.pepTDISHDGEKWIASTPNGTFTATHIIYCTGANSPYLPETNLAALPLRQIRGQTGLTPSTPF|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| a212TDISHDGEKWIASTPNGTFTATHIIYCTGANSPYLPETNLATLPLRQIRGQTGLTPSTPF       310       320       330       340       350       360       370       380       390       400       410       420 m212.pepSEQLRCAVSGESYISPSWHGLHCYGASFIPNSSHTGWNEAEEASNRQALAHLNPALSESL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a212SEQLRCAVSGESYISPSWHGLHCYGASFIPNSSHTGWNEAEEASNRQALAHLNPALSESL       370       380       390       400       410       420       430       440       450       460       470       480 m212.pepFAANPNPQKHQGHAAIRCDSPDHLPLVGALGDIAAMRQTYTKLALDKNYRIDTPCPYLPN||||||||||||||||||||||||||||||||||||:|||:|||||||||||:||||||| a212FAANPNPQKHQGHAAIRCDSPDHLPLVGALGDIAAMQQTYAKLALDKNYRIDAPCPYLPN       430       440       450       460       470       480       490       500       510       520       530       540 m212.pepAYVNTAHGTRGLATAPICAAXXAAQIXGLPHPFXQRLRHALHPNRTIIRAIVRRKDLTPX||:|||||||||||||||||  ||:| |||||: :||||||||||:|||||||||||||| a212AYANTAHGTRGLATAPICAAAVAAEILGLPHPLSKRLRHALHPNRAIIRAIVRRKDLTPX       490       500       510       520       530       540The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 739>:

g214.seq 1 atgatacaaa agatatgtaa gctatttgtt ttaattgtaa tttttgcaac 51ttctcccgct tttgcccttc aaagcgacag cagacggccc atccaaatcg 101 aagccgaccaaggttcgctc gatcaagcca accaaaggac cacatttagc 151 ggcaatgtca tcatcagacagggtacgctc aacatttccg cctcgtgtgt 201 caacgtcaca cgcggcaggc aaaggcggcgaatccgtgag ggcggaaggt 251 tcgcccgtcc gcttcagcca aacgttggac gggggcaaagggacggtgcg 301 cggtcaggca aacaacgtta cctattcctc cgcaggaagc actgtcgttc351 tgaccggcaa tgccaaagtg cagcgcggcg gcgacgttgc cgaaggtgcg 401gtcattacct acaacaccaa aaccgaagtc tataccatca acggcagcac 451 gaaatcgggtgcgaaatccg cttccaaaac cggcagggtc agcgtcgtca 501 tccagccttc aagcacacaaaaaaccgaat aaccccgatg ccgtctgaaa 551 cggaaacgca gttcagacgg catttgccgaccgaaatgcc gagaagagat 601 tattgaThis corresponds to the amino acid sequence <SEQ ID 740; ORF 214. ng>:

g214.pep 1 MIQKICKLFV LIVIFATSPA FALQSDSRRP IQIEADQGSL DQANQRTTFS 51GNVIIRQGTL NISASCVNVT RGRQRRRIRE GGRFARPLQP NVGRGQRDGA 101 RSGKQRYLFLRRKHCRSDRQ CQSAARRRRC RRCGHYLQHQ NRSLYHQRQH 151 EIGCEIRFQN RQGQRRHPAFKHTKNRITPM PSETETQFRR HLPTEMPRRD 201 YThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 741>:

m214.seq (partial) 1 ATGATACAAA AGATATGTAA GCTATTTGTT TTAATAGCATTTTTTTCGGC 51 GTCCCCCGCT TTTGCCCTTC AAAGCGACAG CAGGCAGCCT ATTCAGATTG 101AGGCCGACCA AGGTTCGCTC GATCAAGCCA ACCAAAGCAC CACATTCAGC 151 GGAAACGTCGTCATCAGACA GGGTACGCTC AATATTTCCG CCGCCCGCGT 201 CAATGTTACA CGCGGCGGCAAAGGCGGCGA ATCCGTGAGG GCGGAAGGTT 251 CGCCAGTCCG CTTCAGCCAG ACATTGGACGGCGGCAAAGG CACGGTGCGC 301 GGACAGGCAA ACAACGTTGC TTATTCATCT GCAGGCAGCACCGTAGTCTT 351 AACCGGTAAT GCCAAAGTAC AGCGCGGCGG CGATGTCGCC GAAGGTGCGG401 TGATTACATA CAACACCAAA ACCGAAGTCT ATACCATCAG CGGCAGCACA 451 AAATT...This corresponds to the amino acid sequence <SEQ ID 742; ORF 214>:

m214.pep (partial) 1 MIQKICKLFV LIAFFSASPA FALQSDSRQP IQIEADQGSLDQANQSTTFS 51 GNVVIRQGTL NISAARVNVT RGRQRRRIRE GGRFASPLQP DIGRRQRHGA 101RTGKQRCLFI CRQHRSLNR* CQSTARRRCR RRCGDYIQHQ NRSLYHQRQH 151 KI...Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 214 shows 80.3% identity over a 152 aa overlap with a predicted ORF(ORF 214.ng) from N. gonorrhoeae:

m214/g214         10        20        30        40        50        60m214.pep MIQKICKLFVLIAFFSASPAFALQSDSRQPIQIEADQGSLDQANQSTTFSGNVVIRQGTL||||||||||||::|::|||||||||||:|||||||||||||||| |||||||:|||||| g214MIQKICKLFVLIVIFATSPAFALQSDSRRPIQIEADQGSLDQANQRTTFSGNVIIRQGTL        10        20        30        40        50        60        70        80        90       100       110       120 m214.pepNISAARVNVTRGRQRRRIREGGRFASPLQPDIGRRQRHGARTGKQRCLFICRQHRSLNRX ||||:||||||||||||||||||| ||||::|| || |||:|||| ||: |:|   :| g214NISASCVNVTRGRQRRRIREGGRFARPLQPNVGRGQRDGARSGKQRYLFLRRKHCRSDRQ        70        80        90       100       110       120       130       140       150 m214.pep CQSTARRRCRRRCGDYIQHQNRSLYHQRQHKI|||:|||| |||| |:|||||||||||||:| g214CQSAARRRRCRRCGHYLQHQNRSLYHQRQHEIGCEIRFQNRQGQRRHPAFKHTKNRITPM       130       140       150       160       170       180 g214PSETETQFRRHLPTEMPRRDY        190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 743>:

a214.seq 1 ATGATACAAA AGATATGTAA GCTATTTGTT TTAATAGCAT TTTTTTCGGC 51GTCCCCCGCT TTTGCCCTTC AAAGCGACAG CAGGCAGCCT ATTCAGATTG 101 AGGCCGACCAAGGTTCGCTC GATCAAGCCA ACCAAAGCAC CACATTCAGC 151 GGAAACGTCG TCATCAGACAGGGTACGCTC AATATTTCCG CCGCCCGCGT 201 CAATGTTACA CGCGGC.GGC AAAGGCGGCGAATCCGTGAG GGCGGAAGGT 251 TCGCCAGTCC GCTTCAGCCA GACATTGGAC GGCGGCAAAGGCACGGTGCG 301 CGGACAGGCA AACAACGTTG CTTATTCATC TGCAGGCAGC ACCGTAGTCT351 TAACCGGTAA TGCCAAAGTA CAGCGCGGCG GCGATGTCGC CGAAGGTGCG 401GTGATTACAT ACAACACCAA AACCGAAGTC TATACCATCA GCGGCAGCAC 451 AAAATCCGGCGCAAAATCCG CTTCCAAATC CGGCAGGGTC AGCGTCGTTA 501 TCCAGCCTTC GAGTACGCAAAAATCCGAAT AATCCCAATG CCGTCTGAAA 551 CATAAACCTG GTTCGGACGG CATTTGCCGACCGAAATATT GAAGAGATAT 601 TTATGAThis corresponds to the amino acid sequence <SEQ ID 744; ORF 214.a>:

a214.pep 1 MIQKICKLFV LIAFFSASPA FALQSDSRQP IQIEADQGSL DQANQSTTFS 51GNVVIRQGTL NISAARVNVT RGXQRRRIRE GGRFASPLQP DIGRRQRHGA 101RTGKQRCLFI CRQHRSLNR* CQSTARRRCR RRCGDYIQHQ NRSLYHQRQH 151KIRRKIRFQI RQGQRRYPAF EYAKIRIIPM PSET*TWFGR HLPTEILKRY 201 L* m214/a21499.3% identity in 152 aa overlap        10        20        30        40        50        60 m214.pepMIQKICKLFVLIAFFSASPAFALQSDSRQPIQIEADQGSLDQANQSTTFSGNVVIRQGTL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a214MIQKICKLFVLIAFFSASPAFALQSDSRQPIQIEADQGSLDQANQSTTFSGNVVIRQGTL        10        20        30        40        50        60        70        80        90       100       110       120 m214.pepNISAARVNVTRGRQRRRIREGGRFASPLQPDIGRRQRHGARTGKQRCLFICRQHRSLNRX|||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||| a214NISAARVNVTRGXQRRRIREGGRFASPLQPDIGRRQRHGARTGKQRCLFICRQHRSLNRX        70        80        90       100       110       120       130       140       150 m214.pep CQSTARRRCRRRCGDYIQHQNRSLYHQRQHKI|||||||||||||||||||||||||||||||| a214CQSTARRRCRRRCGDYIQHQNRSLYHQRQHKIRRKIRFQIRQGQRRYPAFEYAKIRIIPM       130       140       150       160       170       180 a214PSETXTWFGRHLPTEILKRYLX        190       200The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 745>:

g214-1.seq 1 ATGATACAAA AGATATGTAA GCTATTTGTT TTAATTGTAA TTTTTGCAAC 51TTCTCCCGCT TTTGCCCTTC AAAGCGACAG CAGACGGCCC ATCCAAATCG 101AAGCCGACCA AGGTTCGCTC GATCAAGCCA ACCAAAGTAC CACATTTAGC 151GGCAATGTCA TCATCAGACA GGGTACGCTC AACATTTCCG CCTCGCGCGT 201CAACGTCACA CGCGGCGGCA AAGGCGGCGA ATCCGTGAGG GCGGAAGGTT 251CGCCCGTCCG CTTCAGCCAA ACGTTGGACG GGGGCAAAGG GACGGTGCGC 301GGTCAGGCAA ACAACGTTAC CTATTCCTCC GCAGGAAGCA CCGTCGTTCT 351GACCGGCAAT GCCAAAGTGC AGCGCGGCGG CGACGTTGCC GAAGGTGCGG 401TCATTACCTA CAACACCAAA ACCGAAGTCT ATACCATCAA CGGCAGCACG 451AAATCGGGTG CGAAATCCGC TTCCAAAACC GGCAGGGTCA GCGTCGTCAT 501CCAGCCTTCA AGCACACAAA AAACCGAATA AThis corresponds to the amino acid sequence <SEQ ID 746; ORF 214-1.ng>:

g214-1.pep 1 MIQKICKLFV LIVIFATSPA FALQSDSRRP IQIEADQGSL DQANQSTTFS 51GNVIIRQGTL NISASRVNVT RGGKGGESVR AEGSPVRFSQ TLDGGKGTVR 101GQANNVTYSS AGSTVVLTGN AKVQRGGDVA EGAVITYNTK TEVYTINGST 151KSGAKSASKT GRVSVVIQPS STQKTE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 747>:

m214-1.seq 1 ATGATACAAA AGATATGTAA GCTATTTGTT TTAATAGCAT TTTTTTCGGC 51GTCCCCCGCT TTTGCCCTTC AAAGCGACAG CAGGCAGCCT ATTCAGATTG 101AGGCCGACCA AGGTTCGCTC GATCAAGCCA ACCAAAGCAC CACATTCAGC 151GGAAACGTCG TCATCAGACA GGGTACGCTC AATATTTCCG CCGCCCGCGT 201CAATGTTACA CGCGGCGGCA AAGGCGGCGA ATCCGTGAGG GCGGAAGGTT 251CGCCAGTCCG CTTCAGCCAG ACATTGGACG GCGGCAAAGG CACGGTGCGC 301GGACAGGCAA ACAACGTTGC TTATTCATCT GCAGGCAGCA CCGTAGTCTT 351AACCGGTAAT GCCAAAGTAC AGCGCGGCGG CGATGTCGCC GAAGGTGCGG 401TGATTACATA CAACACCAAA ACCGAAGTCT ATACCATCAG CGGCAGCACA 451AAATCCGGCG CAAAATCCGC TTCCAAATCC GGCAGGGTCA GCGTCGTTAT 501CCAGCCTTCG AGTACGCAAA AATCCGAATA AThis corresponds to the amino acid sequence <SEQ ID 748; ORF 214-1>:

m214-1.pep 1 MIQKICKLFV LIAFFSASPA FALQSDSRQP IQIEADQGSL DQANQSTTFS 51GNVVIRQGTL NISAARVNVT RGGKGGESVR AEGSPVRFSQ TLDGGKGTVR 101GQANNVAYSS AGSTVVLTGN AKVQRGGDVA EGAVITYNTK TEVYTISGST 151KSGAKSASKS GRVSVVIQPS STQKSE* m214-1/g214-193.8% identity in 176 aa overlap        10        20        30        40        50        60 m214-1.pepMIQKICKLFVLIAFFSASPAFALQSDSRQPIQIEADQGSLDQANQSTTFSGNVVIRQGTL||||||||||||::|::|||||||||||:||||||||||||||||||||||||:|||||| g214-1MIQKICKLFVLIVIFATSPAFALQSDSRRPIQIEADQGSLDQANQSTTFSGNVIIRQGTL        10        20        30        40        50        60        70        80        90       100       110       120 m214-1.pepNISAARVNVTRGGKGGESVRAEGSPVRFSQTLDGGKGTVRGQANNVAYSSAGSTVVLTGN||||:|||||||||||||||||||||||||||||||||||||||||:||||||||||||| g214-1NISASRVNVTRGGKGGESVRAEGSPVRFSQTLDGGKGTVRGQANNVTYSSAGSTVVLTGN        70        80        90       100       110       120       130       140       150       160       170 m214-1.pepAKVQRGGDVAEGAVITYNTKTEVYTISGSTKSGAKSASKSGRVSVVIQPSSTQKSEX||||||||||||||||||||||||||:||||||||||||:||||||||||||||:|| g214-1AKVQRGGDVAEGAVITYNTKTEVYTINGSTKSGAKSASKTGRVSVVIQPSSTQKTEX       130       140       150       160       170 g214-1/p38685sp|P38685|YHBN_ECOLI 17.3 KD PROTEIN IN MURA-RPON INTERGENICREGION PRECURSOR (ORF185)>gi|551336 (U12684) orf185 [Escherichia coli] >gi|606139 (U18997)ORF_o185 [Escherichia coli]>gi|1789592 (AE000399) orf, hypothetical protein [Escherichia coli]Length = 185 Score = 97.1 bits (238), Expect = 6e−20 Identities =57/126 (45%), Positives = 74/126 (58%), Gaps = 3/126 (2%) Query: 19PAFALQSDSRQPIQIEADQGSLDQANQSTTFSGNVVIRQGTLNISAARVNVTR--GGKGG 76 PAFA+ D+ QPI IE+DQ SLD      TF+GNV++ QGT+ I+A +V VTR  G +G Sbjct: 24PAFAVTGDTDQPIHIESDQQSLDMQGNVVTFTGNVIVTQGTIKINADKVVVTRPGGEQGK 83 Query:77 ESVRAEGSPVRFSQTLDGGKGTVRGQANNVAYSSAGSTVVLTGNAKVQRGGDVAEGAVIT 136 E +  G P  F Q  D GK  V G A+ + Y  A   VVLTGNA +Q+     +G  IT Sbjct: 84EVIDGYGKPATFYQMQDNGK-PVEGHASQMHYELAKDFVVLTGNAYLQQVDSNIKGDKIT 142 Query:137 YNTKTE 142 Y  K + Sbjct: 143 YLVKEQ 148The following partial DNA sequence was identified in N. meningitidis<SEQ ID 749>:

a214-1.seq 1 ATGATACAAA AGATATGTAA GCTATTTGTT TTAATAGCAT TTTTTTCGGC 51GTCCCCCGCT TTTGCCCTTC AAAGCGACAG CAGGCAGCCT ATTCAGATTG 101AGGCCGACCA AGGTTCGCTC GATCAAGCCA ACCAAAGCAC CACATTCAGC 151GGAAACGTCG TCATCAGACA GGGTACGCTC AATATTTCCG CCGCCCGCGT 201CAATGTTACA CGCGGCGGCA AAGGCGGCGA ATCCGTGAGG GCGGAAGGTT 251CGCCAGTCCG CTTCAGCCAG ACATTGGACG GCGGCAAAGG CACGGTGCGC 301GGACAGGCAA ACAACGTTGC TTATTCATCT GCAGGCAGCA CCGTAGTCTT 351AACCGGTAAT GCCAAAGTAC AGCGCGGCGG CGATGTCGCC GAAGGTGCGG 401TGATTACATA CAACACCAAA ACCGAAGTCT ATACCATCAG CGGCAGCACA 451AAATCCGGCG CAAAATCCGC TTCCAAATCC GGCAGGGTCA GCGTCGTTAT 501CCAGCCTTCG AGTACGCAAA AATCCGAATA AThis corresponds to the amino acid sequence <SEQ ID 750; ORF 214-1.a>:

a214-1.pep 1 MIQKICKLFV LIAFFSASPA FALQSDSRQP IQIEADQGSL DQANQSTTFS 51GNVVIRQGTL NISAARVNVT RGGKGGESVR AEGSPVRFSQ TLDGGKGTVR 101GQANNVAYSS AGSTVVLTGN AKVQRGGDVA EGAVITYNTK TEVYTISGST 151KSGAKSASKS GRVSVVIQPS STQKSE* a214-1/m214-1100.0% identity in 176 aa overlap        10        20        30        40        50        60 a214-1.pepMIQKICKLFVLIAFFSASPAFALQSDSRQPIQIEADQGSLDQANQSTTFSGNVVIRQGTL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m214-1MIQKICKLFVLIAFFSASPAFALQSDSRQPIQIEADQGSLDQANQSTTFSGNVVIRQGTL        10        20        30        40        50        60        70        80        90       100       110       120 a214-1.pepNISAARVNVTRGGKGGESVRAEGSPVRFSQTLDGGKGTVRGQANNVAYSSAGSTVVLTGN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m214-1NISAARVNVTRGGKGGESVRAEGSPVRFSQTLDGGKGTVRGQANNVAYSSAGSTVVLTGN        70        80        90       100       110       120       130       140       150       160       170 a214-1.pepAKVQRGGDVAEGAVITYNTKTEVYTISGSTKSGAKSASKSGRVSVVIQPSSTQKSEX||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m214-1AKVQRGGDVAEGAVITYNTKTEVYTISGSTKSGAKSASKSGRVSVVIQPSSTQKSEX       130       140       150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 751>:

g215.seq 1 atgaaagtaa gatggcggta cggaattgcg ttcccattga tattggcggt 51tgccttgggc agcctgtcgg catggttggg ccgtatcagc gaagtcgaaa 101tcgaggaagt caggctcaat cccgacgaac ctcaatacac aatggacggc 151ttggacggaa ggcggtttga cgaacaggga tacttgaaag aacatttgag 201cgcgaaaggt gcgaaacagt ttcccgaaaa cagcgacatc cattttgatt 251cgccgcatct cgtgttcttc caagaaggca ggctgttgta cgaagtcggc 301agcgatgaag ccgtttacca taccgaaaac aaacaggttc tttttaaaaa 351caacgttgtg ctgaccaaaa ccgccgacgg caggcggcag gcgggtaaag 401tcgaaaccga aaaactgcac gtcgataccg aatctcaata tgcccaaacc 451gatacgcctg tcagtttcca atatggcgcg tcgcacggtc aggcgggcgg 501tatgacctac aaccacaaaa caggcatgtt gaacttctca tctaaagtga 551aagccgcgat ttatgataca aaagatatgt aaThis corresponds to the amino acid sequence <SEQ ID 752; ORF 215.ng>:

g215.pep 1 MKVRWRYGIA FPLILAVALG SLSAWLGRIS EVEIEEVRLN PDEPQYTMDG 51LDGRRFDEQG YLKEHLSAKG AKQFPENSDI HFDSPHLVFF QEGRLLYEVG 101SDEAVYHTEN KQVLFKNNVV LTKTADGRRQ AGKVETEKLH VDTESQYAQT 151DTPVSFQYGA SHGQAGGMTY NHKTGMLNFS SKVKAAIYDT KDM*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 753>:

m215.seq (partial) 1..AGCCTGTCGG CATGGTTGGG TCGTATCAGC GAAGTCGAGA TTGAAGAAGT 51  CAGGCTCAAT CCCGACGAAC CGCAATACAC AATGGACAGC TTGGACGGCA 101  GGCGGTTTGA CGAACAGGGA TACTTGAAAG AACATTTGAG CGCGAAGGGC 151  GCGAAACAGT TTCCGGAAAG CAGCGACATC CATTTTGATT CGCCGCATCT 201  CGTGTTCTTC CAAGAAGGCA GGTTGTTGTA CGAAGTCGGC AGCGACGAAG 251  CCGTTTACCA TACCGAAAAC AAACAGGTTC TTTTTAAAAA CAACGTTGTG 301  CTGACCAAAA CCGCCGACGG CAAACGGCAG GCGGGTAAAG TTGAAGCCGA 351  AAAGCTGCAC GTCGATACCG AATCTCAATA TGCCCAAACC GATACGCCTG 401  CAGTTTCCA ATATGGTGCA TCGCACGGTC AGGCGGGCGG CATGACTTAC 451  GACCACAwwA CAGGCATGTT GAACTTCTCA TCTAAAGTGA AAGCCACGAT 501  TTATGATACA AAAGATATGT AAThis corresponds to the amino acid sequence <SEQ ID 754; ORF 215>:

m215.pep (partial) 1..SLSAWLGRIS EVEIEEVRLN PDEPQYTMDS LDGRRFDEQG YLKEHLSAKG 51  AKQFPESSDI HFDSPHLVFF QEGRLLYEVG SDEAVYHTEN KQVLFKNNVV 101  LTKTADGKRQ AGKVEAEKLH VDTESQYAQT DTPVSFQYGA SHGQAGGMTY 151  DHXTGMLNFS SKVKATIYDT KDM*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 215 shows 96.0% identity over a 173 aa overlap with a predicted ORF(ORF 215.ng) from N. gonorrhoeae:

m215/g215                             10        20        30        40m215.pep                     SLSAWLGRISEVEIEEVRLNPDEPQYTMDSLDGRRFDEQG                    |||||||||||||||||||||||||||||:|||||||||| g215MKVRWRYGIAFPLILAVALGSLSAWLGRISEVEIEEVRLNPDEPQYTMDGLDGRRFDEQG        10        20        30        40        50        60        50        60        70        80        90       100 m215.pepYLKEHLSAKGAKQFPESSDIHFDSPHLVFFQEGRLLYEVGSDEAVYHTENKQVLFKNNVV||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||| g215YLKEHLSAKGAKQFPENSDIHFDSPHLVFFQEGRLLYEVGSDEAVYHTENKQVLFKNNVV        70        80        90       100       110       120       110       120       130       140       150       160 m215.pepLTKTADGKRQAGKVEAEKLHVDTESQYAQTDTPVSFQYGASHGQAGGMTYDHXTGMLNFS|||||||:|||||||:||||||||||||||||||||||||||||||||||:| ||||||| g215LTKTADGRRQAGKVETEKLHVDTESQYAQTDTPVSFQYGASHGQAGGMTYNHKTGMLNFS       130       140       150       160       170       180        170m215.pep SKVKATIYDTKDMX |||||:||||||| g215 SKVKAAIYDTKDM        190The following partial DNA sequence was identified in N. meningitidis<SEQ ID 755>:

a215.seq 1 ATGAAAGTAA GATGGCGGTA CGGAATTGCG TTCCCATTGA TATTGGCGGT 51TGCCTTGGGC AGCCTGTCGG CATGGTTGGG ACGCATCAGC GAAGTCGAGA 101TTGAAGAAGT CAGGCTCAAT CCCGACGAAC CGCAATACAC AATGGACGGA 151TTGGATGGCA GGCGGTTTGA CGAACAGGGA TACTTGAAAG AACATTTGAG 201TTCGAAGGGC GCGAAACAGT TTCCCGAAAG CAGCGACATT CATTTCGACT 251CACCGCATCT CGTGTTCTTC CAAGAAGGCA GGTTGTTGTA CGAAGTCGGC 301AGCGATGAAG CCGTTTACCA TACCGAAAAC AAACAGGTTC TTTTTAAAAA 351CAACGTTGTG CTGACCAAAA CCGCCGACGG CAAACGGCAG GCGGGTAAAG 401TTGAAGCCGA AAAGCTGCAC GTCGATACCG AATCTCAATA TGCCCAAACC 451GATACGCCTG TCAGTTTCCA ATATGGTGCA TCGCACGGTC AGGCGGGCGG 501CATGACTTAC GACCACAAAA CAGGCATGTT GAACTTCTCA TCTAAAGTGA 551AAGCCACGAT TTATGATACA AAAGATATGT AAThis corresponds to the amino acid sequence <SEQ ID 756; ORF 215.a>:

a215.pep 1 MKVRWRYGIA FPLILAVALG SLSAWLGRIS EVEIEEVRLN PDEPQYTMDG 51LDGRRFDEQG YLKEHLSSKG AKQFPESSDI HFDSPHLVFF QEGRLLYEVG 101SDEAVYHTEN KQVLFKNNVV LTKTADGKRQ AGKVEAEKLH VDTESQYAQT 151DTPVSFQYGA SHGQAGGMTY DHKTGMLNFS SKVKATIYDT KDM* m215/a21598.3% identity in 173 aa overlap                            10        20        30        40 m215.pep                    SLSAWLGRISEVEIEEVRLNPDEPQYTMDSLDGRRFDEQG                    |||||||||||||||||||||||||||||:|||||||||| a215MKVRWRYGIAFPLILAVALGSLSAWLGRISEVEIEEVRLNPDEPQYTMDGLDGRRFDEQG        10        20        30        40        50        60        50        60        70        80        90       100 m215.pepYLKEHLSAKGAKQFPESSDIHFDSPHLVFFQEGRLLYEVGSDEAVYHTENKQVLFKNNVV|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||| a215YLKEHLSSKGAKQFPESSDIHFDSPHLVFFQEGRLLYEVGSDEAVYHTENKQVLFKNNVV        70        80        90       100       110       120       110       120       130       140       150       160 m215.pepLTKTADGKRQAGKVEAEKLHVDTESQYAQTDTPVSFQYGASHGQAGGMTYDHXTGMLNFS|||||||||||||||||||||||||||||||||||||||||||||||||||| ||||||| a215LTKTADGKRQAGKVEAEKLHVDTESQYAQTDTPVSFQYGASHGQAGGMTYDHKTGMLNFS       130       140       150       160       170       180        170m215.pep SKVKATIYDTKDMX |||||||||||||| a215 SKVKATIYDTKDMX        190The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 757>:

g216.seq (partial) 1..atgatatcga tttcgagctc ggtacccagc gacgaaatca ccgccatcat 51  ccccgcactc aaacgcaaag acattaccct cgtctgcatc accgcccgcc 101  ccgattcaac catggcgcgc catgccgata tccacatcac cgcatcggtt 151  tcgcaagaag cctgcccgtt ggggcttgcc ccgaccacca gcaccaccgc 201  cgttatggct ttgggcgacg cgttggcggt cgtcctgctg cgcgcccgcg 251  cgttcacgcc cgacgacttc gccttgatcc accctgccgg cagcctcggc 301  aaacgcctgc ttttgcgcgt tgccgacatt atgcacaaag gcggcggcct 351  gcccgccgtc cgactcggca cgcccttgaa aggagccatc gtcagcatga 401  gcgagaaagg tttgggcatg tgggcgggaa cggacgggca aaggctgtct 451  gaaaggcctt tttactgaThis corresponds to the amino acid sequence <SEQ ID 758; ORF 216.ng>:

g216.pep (partial) 1 ..MISISSSVPS DEITAIIPAL KRKDITLVCI TARPDSTMARHADIHITASV 51   SQEACPLGLA PTTSTTAVMA LGDALAVVLL RARAFTPDDF ALIHPAGSLG101   KRLLLRVADI MHKGGGLPAV RLGTPLKGAI VSMSEKGLGM WAGTDGQRLS 151  ERPFY*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 759>:

m216.seq 1 ATGGCAATGG CAGAAAACGG AAAATATCTC GACTGGGCAC GCGAAGTGTT 51GCACGCCGAA GCGGAAGGCT TGCGCGAAAT TGCAGCGGAA TTGsACAAAA 101 ACTTCGTCCTTGCGGCAGAC GCGTTGTTGC ACTGCAAGGG CAGGGTCGTT 151 ATCACGGGCA TGGTCAAGTCGGGACATATC GGGCGCAAAA TGGCGGCAAC 201 TATGGCCTCG ACCGGCACGC CTGCGTTTTTCGTCCACCCT GCGGAAGCGG 251 CACACGgCGA TTTGGGTATG ATTGTGGACA rCGACGTGGTCGTCGCGATT 301 TCCAATTCCG GCGAAAGCGA CGAAATCGCC GCCATCATCC CCGCACTCAA351 ACGCAAAGAC ATCACGCTTG TCTGCATCAC CGCCCGCCCC GATTCAACCA 401TGGCGCGCCA TGCCGACATC CACATCACGG CGTCGGTTTC CAAAGAAGCC 451 TGCCCGCTGGGGCTTGCCCC GACCACCAGC ACCACCGCCG TCATGGCTTT 501 GGGCGATGCG TTGGCGGTCGTCCtGCTGCG CgcACGCGCG TTCACGCCCG 551 ACGATTTCGC CTTGAGCCAT CCTGCCGGCAGCCTCGGCAA ACGCCTACTT 601 TTGCGCGTTG CCGACATTAT GCACAAAGGC GGCGGCCTGCCTGCCGTCCG 651 ACTCGGCACG CCCTTGAAAG AAGCCATCGT CAGCATGAGT GAAAAAGGGC701 TGGGCATGTT GGCGGTAACG GACGGGCAAG GCCGTCTGAA AGGCGTATTC 751ACCGACGGCG ATTTGCGCCG CCTGTTTCAA GAATGCGACA ATTTTACCGG 801 TCTTTCGATAGACGAAGTCA TGCATACGCA TCCTAAAACC ATCTCCGCCG 851 AACGTCTCGC CACCGAAGCCCTGAAAGTCA TGCAGGCAAA CCATGTGAAC 901 GGGCTTCTGG TTACCGATGC AGATGGCGTGCTGATCGGCG CGCTGAATAT 951 GCACGACCTG CTGGCGGCAC GGATTGTATA GThis corresponds to the amino acid sequence <SEQ ID 760; ORF 216>:

m216.pep 1 MAMAENGKYL DWAREVLHAE AEGLREIAAE LXKNFVLAAD ALLHCKGRVV 51ITGMVKSGHI GRKMAATMAS TGTPAFFVHP AEAAHGDLGM IVDXDVVVAI 101 SNSGESDEIAAIIPALKRKD ITLVCITARP DSTMARHADI HITASVSKEA 151CPLGLAPTTS TTAVMALGDA LAVVLLRARA FTPDDFALSH PAGSLGKRLL 201 LRVADIMHKGGGLPAVRLGT PLKEAIVSMS EKGLGMLAVT DGQGRLKGVF 251 TDGDLRRLFQ ECDNFTGLSIDEVMHTHPKT ISAERLATEA LKVMQANHVN 301 GLLVTDADGV LIGALNMHDL LAARIV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae ORF 216 shows 91.8%identity over a 147 aa overlap with a predicted ORF (ORF 216.ng) from N.gonorrhoeae:

m216/g216   70        80        90      100       110       120 m216.pepTMASTGTPAFFVHPAEAAHGDLGMIVDXDWVAISNSGESDEIAAIIPALKRKDITLVCI                              :::||:|  ||||:|||||||||||||||| g216                              MISISSSVPSDEITAIIPALKRKDITLVCI                                      10        20        30 130       140       150       160       170       180 m216.pepTARPDSTMARHADIHITASVSKEACPLGLAPTTSTTAVMALGDALAVVLLRARAFTPDDF|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| g216TARPDSTMARHADIHITASVSQEACPLGLAPTTSTTAVMALGDALAVVLLRARAFTPDDF        40        50        60        70        80        90 190       200       210       220       230       240 m216.pepALSHPAGSLGKRLLLRVADIMHKGGGLPAVRLGTPLKEAIVSMSEKGLGMLAVTDGQGRL|| |||||||||||||||||||||||||||||||||| |||||||||||| | |||| g216ALIHPAGSLGKRLLLRVADIMHKGGGLPAVRLGTPLKGAIVSMSEKGLGMWAGTDGQRLS       100       110       120       130       140       150The following partial DNA sequence was identified in N. meningitidis<SEQ ID 761>:

a216.seq 1 ATGGCGATGG CAGGAAACGA AAAATATCTT GATTGGGCAC GCGAAGTGTT 51GCACACCGAA GCGGAAGGCT TGCGCGAAAT TGCGGCGGAT TTGGACGAAA 101 ACTTCGCCCTTGCGGCGGAC GCGTTGTTGC ACTGCAAAGG CAGGGTCGTT 151 ATCACGGGCA TGGGCAAGTCGGGACATATC GGGCGCAAAA TGGCGGCAAC 201 CATGGCCTCG ACCGGCACGC CCGCGTTTTTCGTCCACCCT GCGGAAGCGG 251 CACACGGCGA TTTGGGCATG ATTGTGGACA ACGACGTGGTCGTCGCGATT 301 TCCAATTCCG GTGAAAGCGA CGAAATCGCC GCCATCATCC CCGCGCTCAA351 ACGCAAAGAT ATCACGCTTG TCTGCATCAC CGCCCGCCCC GATTCAACCA 401TGGCGCGCCA TGCCGACATC CACATCACGG CGTCGGTTTC CAAAGAAGCC 451 TGCCCGCTGGGGCTTGCCCC GACCACCAGC ACCACCGCCG TTATGGCTTT 501 GGGCGATGCG TTGGCGGTTGTCCTGCTGCG CGCCCGCGCG TTCACGCCCG 551 ACGACTTCGC CTTGAGCCAC CCTGCCGGCAGCCTCGGCAA ACGCCTACTT 601 TTGCGCGTTG CCGACATTAT GCACAAAGGC GGCGGCCTGCCTGCCGTCCG 651 ACTCGGCACG CCCTTGAAAG AAGCCATCGT CAGCATGAGT GAAAAAGGGC701 TGGGCATGTT GGCGGTAACG GACGGGCAAG GCCGTCTGAA AGGCGTATTC 751ACCGACGGCG ATTTGCGCCG CCTGTTTCAA GAATGCGACA ATTTTACCGG 801 TCTTTCGATAGACGAAGTCA TGCATACGCA TCCTAAAACC ATCTCCGCCG 851 AACGTCTCGC CACCGAAGCCCTGAAAGTCA TGCAGGCAAA CCATGTGAAC 901 GGGCTTCTGG TTACCGATGC AGATGGCGTGCTGATCGGCG CGCTGAATAT 951 GCACGACCTT TTGGCGGCGC GGATTGTATA GThis corresponds to the amino acid sequence <SEQ ID 762; ORF 216.a>:

a216.pep 1 MAMAGNEKYL DWAREVLHTE AEGLREIAAD LDENFALAAD ALLHCKGRVV 51ITGMGKSGHI GRKMAATMAS TGTPAFFVHP AEAAHGDLGM IVDNDVVVAI 101 SNSGESDEIAAIIPALKRKD ITLVCITARP DSTMARHADI HITASVSKEA 151CPLGLAPTTS TTAVMALGDA LAVVLLRARA FTPDDFALSH PAGSLGKRLL 201 LRVADIMHKGGGLPAVRLGT PLKEAIVSMS EKGLGMLAVT DGQGRLKGVF 251 TDGDLRRLFQ ECDNFTGLSIDEVMHTHPKT ISAERLATEA LKVMQANHVN 301 GLLVTDADGV LIGALNMHDL LAARIV*m216/a216 97.2% identity in 326 aa overlap        10        20        30        40        50        60 m216.pepMAMAENGKYLDWAREVLHAEAEGLREIAAELXKNFVLAADALLHCKGRVVITGMVKSGHI|||| | |||||||||||:||||||||||:| :||:|||||||||||||||||| ||||| a216MAMAGNEKYLDWAREVLHTEAEGLREIAADLDENFALAADALLHCKGRVVITGMGKSGHI        10        20        30        40        50        60        70        80        90       100       110       120 m216.pepGRKMAATMASTGTPAFFVHPAEAAHGDLGMIVDXDVVVAISNSGESDEIAAIIPALKRKD||||||||||||||||||||||||||||||||| |||||||||||||||||||||||||| a216GRKMAATMASTGTPAFFVHPAEAAHGDLGMIVDNDVVVAISNSGESDEIAAIIPALKRKD        70        80        90       100       110       120       130       140       150       160       170       180 m216.pepITLVCITARPDSTMARHADIHITASVSKEACPLGLAPTTSTTAVMALGDALAVVLLRARA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a216ITLVCITARPDSTMARHADIHITASVSKEACPLGLAPTTSTTAVMALGDALAVVLLRARA       130       140       150       160       170       180       190       200       210       220       230       240 m216.pepFTPDDFALSHPAGSLGKRLLLRVADIMHKGGGLPAVRLGTPLKEAIVSMSEKGLGMLAVT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a216FTPDDFALSHPAGSLGKRLLLRVADIMHKGGGLPAVRLGTPLKEAIVSMSEKGLGMLAVT       190       200       210       220       230       240       250       260       270       280       290       300 m216.pepDGQGRLKGVFTDGDLRRLFQECDNFTGLSIDEVMHTHPKTISAERLATEALKVMQANHVN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a216DGQGRLKGVFTDGDLRRLFQECDNFTGLSIDEVMHTHPKTISAERLATEALKVMQANHVN       250       260       270       280       290       300       310       320 m216.pep GLLVTDADGVLIGALNMHDLLAARIVX||||||||||||||||||||||||||| a216 GLLVTDADGVLIGALNMHDLLAARIVX       310       320The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 763>:

g217.seq 1 atggcggatg acggtttgtt gcggcaactg tccgaaaaac ccagccaaag 51tgctctcttc ctgccatttg acccattcgt tttcgaggtt ttggactgcc 101 ttttggtcatcgggcccggc ttgaaacaat gtttcaagca aatcccggca 151 acgcgccacc cattcgccgaccgtcgcagg ttgccgccat atccgggcaa 201 tatccgacag ggtttcgagg aaggcggcaaaacgtccgaa catggcggtt 251 tgattcacgt cggcatacca cgcgctgaca tcctgccacatcgggttgcc 301 gccttcgggc agcatccagc ccaatatcat acggtctgcc gcctgcttcc351 aggtaaacag ctgatccgtg ccgccgcgca tttctccgtc caatccccaa 401tggacgttca aatcggcaac catatcgtgc aaaagcggca aatcgtcccc 451 ggtcagtccgaaacggcgca acacgggcgc ggtttccaaa agcgcgagca 501 ctttgccgac ttcaaaacggctttccagca agtcggacac gcactccaac 551 gcataaaaaa acggttgccg gcggctgattttcacgtccg aaacggaata 601 cggcaatgcc tgcgcgccgg gttgcgcctg tccgaacacggcttccataa 651 aaggcgtata gggttcgata ttcggggtta aThis corresponds to the amino acid sequence <SEQ ID 764; ORF 217.ng>:

g217.pep.. 1 MADDGLLRQL SEKPSQSALF LPFDPFVFEV LDCLLVIGPG LKQCFKQIPA 51TRHPFADRRR LPPYPGNIRQ GFEEGGKTSE HGGLIHVGIP RADILPHRVA 101 AFGQHPAQYHTVCRLLPGKQ LIRAAAHFSV QSPMDVQIGN HIVQKRQIVP 151 GQSETAQHGR GFQKREHFADFKTAFQQVGH ALQRIKKRLP AADFHVRNGI 201 RQCLRAGLRL SEHGFHKRRI GFDIRG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 765>:

m217.seq 1 ATGGCGGATG ACGGTGTGCG GCGGCAACTG TCCGGAAAAT TGCGCCAATT 51CGGTTTCCGC CTrCCATTTG ACCCATTCGT TTTCAAGGTT TTGGACTGAC 101 TTTTGGTCATCGGCTTCAGC TTGGAACAAT GTTTCAAGCA AATCCCGGCA 151 ACGCGCCACC CATTCGCCGACCGTTGCGGG CTGCCGCCAT ATCCGTACAA 201 TATCCGTCAG GGTTTCGAGG AAGGCGGCAAAACGTCCGAA CATGGCGGTT 251 TGATTCACGT CGGCATACCA CGCGCTGACA TCCTGCCACATCGGATTGCC 301 GCCTTTGGGC AGCATCCAGC CCAATATCAT GCGTTCTACC GCCTGCTTCC351 AGGTGAACAG CTGATCCGTG CCGCCGCGCA TTTCTCCGTC CAAACCCCAG 401TGGACGTTCA AATCGGCAAC CATGTCGTGC AAAAGCGGTA AATCGTCCTC 451 AGTCAGTCCGAAACGGCGCA ACACGGGCGC GGTTTCTAAA AGCACAAGCA 501 CTTTATCGAC TTCAAATCGGCTTTCCAACA AGTCGAACAG GCATGACAAA 551 GCATGAAACA GCGGTTGGCG GCGGCTGATTTTCACGTCTG ACACGGAATA 601 CGGCAATGCC TGCGCACCgG GctGCGCCTG TCCGAACACGGCTTCGATAA 651 AAGGCGTATA GGATTCGATA TTCGGGGTTA AThis corresponds to the amino acid sequence <SEQ ID 766; ORF 217>:

m217.pep 1 MADDGVRRQL SGKLRQFGFR LPFDPFVFKV LDXLLVIGFS LEQCFKQIPA 51TRHPFADRCG LPPYPYNIRQ GFEEGGKTSE HGGLIHVGIP RADILPHRIA 101 AFGQHPAQYHAFYRLLPGEQ LIRAAAHFSV QTPVDVQIGN HVVQKRXIVL 151 SQSETAQHGR GFXKHKHFIDFKSAFQQVEQ AXQSMKQRLA AADFHVXHGI 201 RQCLRTGLRL SEHGFDKRRI GFDIRG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 217 shows 80.5% identity over a 226 aa overlap with a predicted ORF(ORF 217.ng) from N. gonorrhoeae:

m217/g217         10        20        30        40        50        60m217.pep MADDGVRRQLSGKLRQFGFRLPFDPFVFKVLDXLLVIGFSLEQCFKQIPATRHPFADRCG|||||: |||| |  | :: ||||||||:||| ||||| :|:|||||||||||||||| g217MADDGLLRQLSEKPSQSALFLPFDPFVFEVLDCLLVIGPGLKQCFKQIPATRHPFADRRR        10        20        30        40        50        60        70        80        90       100       110       120 m217.pepLPPYPYNIRQGFEEGGKTSEHGGLIHVGIPRADILPHRIAAFGQHPAQYHAFYRLLPGEQ||||| ||||||||||||||||||||||||||||||||:|||||||||||:  |||||:| g217LPPYPGNIRQGFEEGGKTSEHGGLIHVGIPRADILPHRVAAFGQHPAQYHTVCRLLPGKQ        70        80        90       100       110       120       130       140       150       160       170       180 m217.pepLIRAAAHFSVQTPVDVQIGNHVVQKRXIVLSQSETAQHGRGFXKHKHFIDFKSAFQQVEQ|||||||||||:|:|||||||:|||| || :||||||||||| |::|| |||:||||| : g217LIRAAAHFSVQSPMDVQIGNHIVQKRQIVPGQSETAQHGRGFQKREHFADFKTAFQQVGH       130       140       150       160       170       180       190       200       210       220 m217.pepAXQSMKQRLAAADFHVXHGIRQCLRTGLRLSEHGFDKRRIGFDIRGX| | :|:|| |||||| :|||||||:||||||||| |||||||||| g217ALQRIKKRLPAADFHVRNGIRQCLRAGLRLSEHGFHKRRIGFDIRG       190       200       210       220The following partial DNA sequence was identified in N. meningitidis<SEQ ID 767>:

a217.seq 1 GTGGCGGATG ACGGTGTGCA GCGGCAACTG TCCGGAAAAT TGCGCCAATT 51CGGTTTCCGC CTGCCATTTG ACCCATTCGT TTTCGAGGCT TTGGACTGCC 101 TTTTGGTCATCGCCTTCGAC TTGGAACAAT GTTTCAAGCA AATCCCGGCA 151 ACGCGCCACC CATTCGTCAACCGTCGCAGG TTGCCGCCAT ATCCGTACAA 201 TATCCGTCAG GGTTTCGAGG AAGGCGGCAAAACGTCCGAA CAGGGCGGTT 251 TGGTTCACGT CGGCATACCA CGCGCTGACC CCCTGCCACATCGGATTGCC 301 GCCTTCGGGC AGCATCCAGC CCAATATCAT GCGTTCTACC GCCTGCTTCC351 AGGTGAACAG CTGATCCGTG CCGCCGCGCA TTTCTCCGTC CAAACCCCAG 401CGGACGTTCA AATCGGCAAC CATGTCGTGC AAAAGCGGCA AATCGTCCTC 451 AGTCAGTCCGAAATGGCGCA ACACGGGCGC GGTTTCTAAA AGCACAAGCA 501 CTTTATCGAC TTCAAATCGGCTTTCCAACA AGTCGAACAG GCATGACAAA 551 GCATGAAACA GCGGTTGTCG GCGGCTGATTTTCACATCCG AAACGGAATA 601 CGGCAATGCC TGCGCGCCGG GCTGCGCCTG TCCGAACACGGCTTCGATAA 651 AAGGCGTATA GGATTCGATA TTCGGGGTTA AThis corresponds to the amino acid sequence <SEQ ID 768; ORF 217.a>:

a217.pep 1 VADDGVQRQL SGKLRQFGFR LPFDPFVFEA LDCLLVIAFD LEQCFKQIPA 51TRHPFVNRRR LPPYPYNIRQ GFEEGGKTSE QGGLVHVGIP RADPLPHRIA 101 AFGQHPAQYHAFYRLLPGEQ LIRAAAHFSV QTPADVQIGN HVVQKRQIVL 151 SQSEMAQHGR GF*KHKHFIDFKSAFQQVEQ A*QSMKQRLS AADFHIRNGI 201 RQCLRAGLRL SEHGFDKRRI GFDIRG*m217/a217 90.3% identity in 226 aa overlap        10        20        30        40        50        60 m217.pepMADDGVRRQLSGKLRQFGFRLPFDPFVFKVLDXLLVIGFSLEQCFKQIPATRHPFADRCG:|||||:|||||||||||||||||||||::|| ||||:|:|||||||||||||||::| a217VADDGVQRQLSGKLRQFGFRLPFDPFVFEALDCLLVIAFDLEQCFKQIPATRHPFVNRRR        10        20        30        40        50        60        70        80        90       100       110       120 m217.pepLPPYPYNIRQGFEEGGKTSEHGGLIHVGIPRADILPHRIAAFGQHPAQYHAFYRLLPGEQ||||||||||||||||||||:|||:|||||||| |||||||||||||||||||||||||| a217LPPYPYNIRQGFEEGGKTSEQGGLVHVGIPRADPLPHRIAAFGQHPAQYHAFYRLLPGEQ        70        80        90       100       110       120       130       140       150       160       170       180 m217.pepLIRAAAHFSVQTPVDVQIGNHVVQKRXIVLSQSETAQHGRGFXKHKHFIDFKSAFQQVEQ|||||||||||||:|||||||||||| ||||||| ||||||||||||||||||||||||| a217LIRAAAHFSVQTPADVQIGNHVVQKRQIVLSQSEMAQHGRGFXKHKHFIDFKSAFQQVEQ       130       140       150       160       170       180       190       200       210       220 m217.pepAXQSMKQRLAAADFHVXHGIRQCLRTGLRLSEHGFDKRRIGFDIRGX |||||||||:|||||::|||||||:||||||||||||||||||||| a217AXQSMKQRLSAADFHIRNGIRQCLRAGLRLSEHGFDKRRIGFDIRGX       190       200       210       220The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 769>:

g218.seq 1 atggttgcgg tggatcctta tacggcaaaa gtggtcaaca ccatgccgcg 51caatcagggt tggtatcaca ctatggatga aatccacggc gatatgatgc 101 tcggtgcggcaggcgattat cttttggaaa cggcagcttc actgaccatt 151 attatggttg tcagcggcttgtacctttgg tgggcgaaac agcgcggcat 201 taaagcgatg ctgctgccgc caaaaagcagggcgcgttct tggtggcgga 251 atctgcacgg cgcgtttgga acttgggtgt cgttgattttactgttgttc 301 tgcctgtcgg gtattgcttg ggcaggtatt tggggcggca aattcgtgca351 ggcttggaat cagttcccgg ccggcaaatg gggtgtcgaa ccgaaccccg 401tttcaatcgt gccgacccac ggcgaggtat tgaatgacgg caaggttaag 451 gaagtgccgtggattttgga gcttatgcct atgcctgtct cagggacgac 501 tgtgggtgaa aacggcattaaccccaccga gcccaataac attggaaacc 551 gtcgaccgtt tcgcgcggga aatcggtttcaaagggcgtt atcagttgaa 601 tttgcccaaa ggcgaggacg gggtatggac tttgtcgcaggattctatga 651 gttatgaThis corresponds to the amino acid sequence <SEQ ID 770; ORF 218.ng>:

g218.pep 1 MVAVDPYTAK VVNTMPRNQG WYHTMDEIHG DMMLGAAGDY LLETAASLTI 51IMVVSGLYLW WAKQRGIKAM LLPPKSRARS WWRNLHGAFG TWVSLILLLF 101CLSGIAWAGI WGGKFVQAWN QFPAGKWGVE PNPVSIVPTH GEVLNDGKVK 151 EVPWILELMPMPVSGTTVGE NGINPTEPNN IGNRRPFRAG NRFQRALSVE 201 FAQRRGRGMD FVAGFYEL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 771>:

m218.seq 1 ATGGTCGCGG TCGATCCTTA TACGGCAAAA GTGGTCAGTA CCATGCCGCG 51CAATCAGGGT TGGTATTACA CGATGGATGA AATCCACAGC GATATGATGC 101TCGGTGCGGC AGGCGATTAT CTTTTGGAAA CGGCAGCTTC ACTGACCATT 151ATTATGGTTG TCAGCGGCTT GTACCTTTGG TGGGTGAAAC GGCGCGGCAT 201CAAGGCGATG CTGCTGCCGT CAAAAGGCAr GGCGCGTTCT TGGTGGCGGA 251ATCTGCACGG CACGTTTGGA ACTTGGGTGT CGTTGATTTT GCTGTTGTTC 301TGCCTGTCGG GTATTGCTTG GGCGGGTATT TGGGGCGGCA AGTTCGTACA 351GGCTTGGAGT CAGTTCCCTG CCGGTAAATG GGGTGTCGAA CCGAACCCCG 401TTTCAGTCGT GCCGACCCAC GGCGAGGTAT TGAATGACGG CAAGGTTAAG 451GAAGTGCCGT GGGTTTTGGA GCTTACGCCT ATGCCTGTTT CAGGGACGaC 501yGtgGGCAAA GACGGCATTA ACCCTGACGA GCCGATGACA TTGGAAACCG 551TCGACCGCTT TGCGCGGnGA AATCGGTTTC AAAGGGCGTT ATCAGTTGAA 601TTTGCCCAAA GGCGAGGACG GCGTATGGAC TTTGTCGCAG GATTCTATGA 651 GTTAThis corresponds to the amino acid sequence <SEQ ID 772; ORF 218>:

m218.pep 1 MVAVDPYTAK VVSTMPRNQG WYYTMDEIHS DMMLGAAGDY LLETAASLTI 51IMVVSGLYLW WVKRRGIKAM LLPSKGXARS WWRNLHGTFG TWVSLILLLF 101CLSGIAWAGI WGGKFVQAWS QFPAGKWGVE PNPVSVVPTH GEVLNDGKVK 151EVPWVLELTP MPVSGTTVGK DGINPDEPMT LETVDRFARX NRFQRALSVE 201FAQRRGRRMD FVAGFYELComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 218 shows 87.2% identity over a 218 aa overlap with a predicted ORF(ORF 218.ng) from N. gonorrhoeae:

m218/g218         10        20        30        40        50        60m218.pep MVAVDPYTAKVVSTMPRNQGWYYTMDEIHSDMMLGAAGDYLLETAASLTIIMVVSGLYLW||||||||||||:|||||||||:||||||:|||||||||||||||||||||||||||||| g218MVAVDPYTAKVVNTMPRNQGWYHTMDEIHGDMMLGAAGDYLLETAASLTIIMVVSGLYLW        10        20        30        40        50        60        70        80        90       100       110       120 m218.pepWVKRRGIKAMLLPSKGXARSWWRNLHGTFGTWVSLILLLFCLSGIAWAGIWGGKFVQAWS|:|:||||||||| |: ||||||||||:|||||||||||||||||||||||||||||||: g218WAKQRGIKAMLLPPKSRARSWWRNLHGAFGTWVSLILLLFCLSGIAWAGIWGGKFVQAWN        70        80        90       100       110       120       130       140       150       160       170       180 m218.pepQFPAGKWGVEPNPVSVVPTHGEVLNDGKVKEVPWVLELTPMPVSGTTVGKDGINPDEPMT|||||||||||||||:||||||||||||||||||:||| ||||||||||::|||| || : g218QFPAGKWGVEPNPVSIVPTHGEVLNDGKVKEVPWILELMPMPVSGTTVGENGINPTEPNN       130       140       150       160       170       180       190       200       210 m218.pepLETVDRFARXNRFQRALSVEFAQRRGRRMDFVAGFYEL : :   |   ||||||||||||||||||||||||||| g218 IGNRRPFRAGNRFQRALSVEFAQRRGRGMDFVAGFYEL       190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 773>:

a218.seq 1 ATGGTCGCGG TCGATCCTTA TACGGCAAAA GTGGTCAGTA CCATGCCGCG 51CAATCAGGGT TGGTATTACG CGATGGATGA AATCCACAGC GATATGATGC 101TCGGTTCGAC AGGTGATTAT CTTTTGGAAA CGGCTGCATC GCTGACGATT 151ATCATGATAA TCAGCGGTTT GTACCTTTGG TGGGTGAAAC GGCGCGGCAT 201CAAGGCGATG CTGCTGCCGC CAAAAGGCAG GGCGCGTTCT TGGTGGCGGA 251ATCTGCACGG CGCGTTTGGA ACTTGGGTGT CGTTGATTTT ACTGTTGTTC 301TGCCTGTCGG GTATTGCTTG GGCAGGTATT TGGGGCGGCA AGTTCGTGCA 351GGCTTGGAGT CAGTTCCCGG CAGGCAAATG GGGTGTCGAA CCGAACCCTG 401TTTCAGTCGT GCCGACCCAC GGCGAGGTAT TGAATGACGG CAAGGTTAAG 451GAAGTGCCGT GGGTTTTGGA GCTTACGCCT ATGCCTGTTT CAGGGACGAC 501TGTGGGCAAA GACGGTATTA ACCCTGACGA GCCGATGACA TTGGAAACCG 551TCGACCGTTT TGCGCGG.GA AATCGGTTTC AAAGGGCGTT ATCAGCTGAA 601TTTGCCCAAA GGCGAGGACG GCGTATGGAC TTTGTCGCAG GATTCTATGA 651 GTTAThis corresponds to the amino acid sequence <SEQ ID 774; ORF 218.a>:

a218.pep 1 MVAVDPYTAK VVSTMPRNQG WYYAMDEIHS DMMLGSTGDY LLETAASLTI 51IMIISGLYLW WVKRRGIKAM LLPPKGRARS WWRNLHGAFG TWVSLILLLF 101CLSGIAWAGI WGGKFVQAWS QFPAGKWGVE PNPVSVVPTH GEVLNDGKVK 151EVPWVLELTP MPVSGTTVGK DGINPDEPMT LETVDRFARX NRFQRALSAE 201FAQRRGRRMD FVAGFYEL m218/a218 95.9% identity in 218 aa overlap        10        20        30        40        50        60 m218.pepMVAVDPYTAKVVSTMPRNQGWYYTMDEIHSDMMLGAAGDYLLETAASLTIIMVVSGLYLW|||||||||||||||||||||||:|||||||||||::|||||||||||||||::|||||| a218MVAVDPYTAKVVSTMPRNQGWYYAMDEIHSDMMLGSTGDYLLETAASLTIIMIISGLYLW        10        20        30        40        50        60        70        80        90       100       110       120 m218.pepWVKRRGIKAMLLPSKGXARSWWRNLHGTFGTWVSLILLLFCLSGIAWAGIWGGKFVQAWS||||||||||||| || ||||||||||:|||||||||||||||||||||||||||||||| a218WVKRRGIKAMLLPPKGRARSWWRNLHGAFGTWVSLILLLFCLSGIAWAGIWGGKFVQAWS        70        80        90       100       110       120       130       140       150       160       170       180 m218.pepQFPAGKWGVEPNPVSVVPTHGEVLNDGKVKEVPWVLELTPMPVSGTTVGKDGINPDEPMT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a218QFPAGKWGVEPNPVSVVPTHGEVLNDGKVKEVPWVLELTPMPVSGTTVGKDGINPDEPMT       130       140       150       160       170       180       190       200       210 m218.pepLETVDRFARXNRFQRALSVEFAQRRGRRMDFVAGFYEL||||||||||||||||||:||||||||||||||||||| a218LETVDRFARXNRFQRALSAEFAQRRGRRMDFVAGFYEL        190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 775>:

g219.seq 1 atgacggcaa ggttaaggaa gtgccgtgga ttttggagct tatgcctatg 51cctgtctcag ggacgactgt gggtgaaaac ggcattaacc ccaccgagcc 101caataacatt ggaaaccgtc gaccgtttcg cgcgggaaat cggtttcaaa 151gggcgttatc agttgaattt gcccaaaggc gaggacgggg tatggacttt 201gtcgcaggat tctatgagtt atgacatgat cagcccgttt gccgaccgca 251cggtacatat cgaccagtac agcggcgaga ttcttgccga catccgtttt 301gacgattaca acccgttcgg caaatttatg gcggcaagca ttgcgctgca 351tatggggact ttgggctggt ggagcgtgtt ggcgaacgtc gtgttctgcc 401ttgccgtgat ttttatcggc atcagcggct gcgtgatgtg gtggaaacgc 451cgtccgtccg gcgtggcggg cattgttcct ccggcgcaaa aaatcaaact 501gcccgtctgg tgggcgatgg cattgccgct gctgttgatt gcactgcttt 551tcccgaccgc gctgcttgcc attgccgtga tttggctgtt ggataccttg 601ctgctgtcgc ggattcctgt gttgaggaaa tggtttaaat gaThis corresponds to the amino acid sequence <SEQ ID 776; ORF 219.ng>:

g219.pep 1 MTARLRKCRG FWSLCLCLSQ GRLWVKTALT PPSPITLETV DRFAREIGFK 51GRYQLNLPKG EDGVWTLSQD SMSYDMISPF ADRTVHIDQY SGEILADIRF 101DDYNPFGKFM AASIALHMGT LGWWSVLANV VFCLAVIFIG ISGCVMWWKR 151RPSGVAGIVP PAQKIKLPVW WAMALPLLLI ALLFPTALLA IAVIWLLDTL 201LLSRIPVLRK WFK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 777>:

m219.seq 1 ATGACGGCAA GGTTAAGGAA GTGCCGTGGG TTTTGGAGCT TACGCCTATG 51CCTGTTTCAG GGACGaCyGt gGGCAAAGAC GGCATTAACC CTGACGAGCC 101GATGACATTG GAAACCGTCG ACCGCTTTGC GCGGnGAAAT CGGTTTCAAA 151GGGCGTTATC AGTTGAATTT GCCCAAAGGC GAGGACGGCG TATGGACTTT 201GTCGCAGGAT TCTATGAGTT ACGACATGAT CAGCCCGTTT GCCGACCGCA 251CGGTACATAT CGACCAGTAC AGCGGCAAAA TCCTTGCCGA CATCCGTTTT 301GACGATTACA ACCCGTTCGG CAAATTTATG GCGGCAAGCA TTGCGCTGCA 351TATGGGGACT CTGGGCTGGT GGAGCGTGTT GGCGAACGTC TTGTTCTGCC 401TTGCCGTCAT TTTTATCGGT ATCAGCGGCT GCGTGATGTG GTGGAAACGC 451CGTCCGACCG GAGCGGTGGG CATCGTTCCG CCGGCGCAGA AAGTCAAGCT 501GCCGGTTTGG TGGATGATGG CATTGCCGCT ATTGGCAATC GCACTGCTCT 551TCCCGACCTC ACTGCTTGCC ATTGCCGTGA TTTGGCTGTT GGATACGCTG 601CTGTTGTCGC GGATTCCTGT TTTGAGGAGA TGGTTTAAAT GAThis corresponds to the amino acid sequence <SEQ ID 778; ORF 219>:

m219.pep 1 MTARLRKCRG FWSLRLCLFQ GRXWAKTALT LTSRXHWKPS TALRGEIGFK 51GRYQLNLPKG EDGVWTLSQD SMSYDMISPF ADRTVHIDQY SGKILADIRF 101DDYNPFGKFM AASIALHMGT LGWWSVLANV LFCLAVIFIG ISGCVMWWKR 151RPTGAVGIVP PAQKVKLPVW WMMALPLLAI ALLFPTSLLA IAVIWLLDTL 201LLSRIPVLRR WFK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 219 shows 86.9% identity over a 213 aa overlap with a predicted ORF(ORF 219.ng) from N. gonorrhoeae:

m219/g219         10        20        30        40        50        60m219.pep MTARLRKCRGFWSLRLCLFQGRXWAKTALTLTSRXHWKPSTALRGEIGFKGRYQLNLPKG|||||||||||||| ||| ||| |:|||||  |    :    :  ||||||||||||||| g219MTARLRKCRGFWSLCLCLSQGRLWVKTALTPPSPITLETVDRFAREIGFKGRYQLNLPKG        10        20        30        40        50        60        70        80        90       100       110       120 m219.pepEDGVWTLSQDSMSYDMISPFADRTVHIDQYGKILADIRFDDYNPFGKFMAASIALHMGT||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||| g219EDGVWTLSQDSMSYDMISPFADRTVHIDQYSGEILADIRFDDYNPFGKFMAASIALHMGT        70        80        90       100       110       120       130       140       150       160       170       180 m219.pepLGWWSVLANVLFCLAVIFIGISGCVMWWKRRPTGAVGIVPPAQKVKLPVWWMMALPLLAI||||||||||:|||||||||||||||||||||:|::||||||||:|||||| |||||| | g219LGWWSVLANVVFCLAVIFIGISGCVMWWKRRPSGVAGIVPPAQKIKLPVWWAMALPLLLI       130       140       150       160       170       180       190       200       210 m219.pepALLFPTSLLAIAVIWLLDTLLLSRIPVLRRWFKX ||||||:||||||||||||||||||||||:|||g219 ALLFPTALLAIAVIWLLDTLLLSRIPVLRKWFK        190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 779>:

a219.seq 1 ATGACGGCAA GGTTAAGGAA GTGCCGTGGG TTTTGGAGCT TACGCCTATG 51CCTGTTTCAG GGACGACTGT GGGCAAAGAC GGTATTAACC CTGACGAGCC 101GATGACATTG GAAACCGTCG ACCGTTTTGC GCGG.GAAAT CGGTTTCAAA 151GGGCGTTATC AGCTGAATTT GCCCAAAGGC GAGGACGGCG TATGGACTTT 201GTCGCAGGAT TCTATGAGTT ACGACATGAT CAGCCCGTTT GCTGACCGCA 251CGGTGCATAT CGACCAGTAC AGCGGCAAGA TTCTTGCCGA CATCCGTTTT 301GACGATTACA ACCCGTTCGG CAAATTTATG GCGGCAAGCA TTGCGCTGCA 351TATGGGGACT TTGGGCTGGT GGAGCGTGTT GGCGAACGTT TTGTTCTGCC 401TTGCCGTGAT TTTTATCGGC ATCAGCGGCT GCGTGATGTG GTGGAAACGC 451CGTCCGTCCG GCGCGGTGGG CATGGTTCCG CCGGCGCAAA AAATCAAGCT 501GCCCGTCTGG TGGGCAATGG CGGTGCCGCT GCTGCTGATT GCATTGCTTT 551TCCCGACCGC GTTGCTTGCC ATTGCCGTGA TTTGGCTGTT GGATACGCTG 601CTGTTGTCGC GGATTCCTGT TTTGAGGAGA TGGTTTAAAT GAThis corresponds to the amino acid sequence <SEQ ID 780; ORF 219.a>:

a219.pep 1 MTARLRKCRG FWSLRLCLFQ GRLWAKTVLT LTSR*HWKPS TVLRXEIGFK 51GRYQLNLPKG EDGVWTLSQD SMSYDMISPF ADRTVHIDQY SGKILADIRF 101DDYNPFGKFM AASIALHMGT LGWWSVLANV LFCLAVIFIG ISGCVMWWKR 151RPSGAVGMVP PAQKIKLPVW WAMAVPLLLI ALLFPTALLA IAVIWLLDTL 201LLSRIPVLRR WFK* m219/a219 94.8% identity in 213 aa overlap        10        20        30        40        50        60 m219.pepMTARLRKCRGFWSLRLCLFQGRXWAKTALTLTSRXHWKPSTALRGEIGFKGRYQLNLPKG|||||||||||||||||||||| ||||:|||||||||||||:|| ||||||||||||||| a219MTARLRKCRGFWSLRLCLFQGRLWAKTVLTLTSRXHWKPSTVLRXEIGFKGRYQLNLPKG        10        20        30        40        50        60        70        80        90       100       110       120 m219.pepEDGVWTLSQDSMSYDMISPFADRTVHIDQYSGKILADIRFDDYNPFGKFMAASIALHMGT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a219EDGVWTLSQDSMSYDMISPFADRTVHIDQYSGKILADIRFDDYNPFGKFMAASIALHMGT        70        80        90       100       110       120       130       140       150       160       170       180 m219.pepLGWWSVLANVLFCLAVIFIGISGCVMWWKRRPTGAVGIVPPAQKVKLPVWWMMALPLLAI||||||||||||||||||||||||||||||||:||||:||||||:|||||| ||:||| | a219LGWWSVLANVLFCLAVIFIGISGCVMWWKRRPSGAVGMVPPAQKIKLPVWWAMAVPLLLI       130       140       150       160       170       180       190       200       210 m219.pepALLFPTSLLAIAVIWLLDTLLLSRIPVLRRWFKX ||||||:|||||||||||||||||||||||||||a219 ALLFPTALLAIAVIWLLDTLLLSRIPVLRRWFKX        190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 781>:

g221.seq 1 atgcacgacc acggcgccat ggatcgccgc ctccccgctt tcggaagtct 51gatgcggcga gccgtaaatc adatcgacgc tgacggattt gaaccctgcc 101tcacgggcgg catcgatgac ttctttggtt tcttcgtagc tttggatgcg 151gttgactgcc gcctgcactt tggggtcgaa atcctgaatg ccgacgctca 201tgcggttgaa gccgagtctg ccgagcatga ggacggtgtc gcggctgact 251ttgcgcgggt cgatttcgat ggaatattcg ccggacggta tcagttcgaa 301atgtttgcgg atcatgcgga agacacgttc gatctgttcg tcgctcaaaa 351aggtcggcgt gccgccgccg aagtgcagtt gggcaagctg gtgccgtccg 401ttcagatgtg gagcgagcag ttccatttct ttttcaagat attcgatgta 451ggtatcggcg cggcttttgt ctttggtgat gattttgttg cagccgcagt 501agtagcagat ggtgttgcaa aacggaatgt gaatgtaaag ggaaagcggt 551 ttgtttaaThis corresponds to the amino acid sequence <SEQ ID 782; ORF 221.ng>:

g221.pep 1 MHDHGAMDRR LPAFGSLMRR AVNXIDADGF EPCLTGGIDD FFGFFVALDA 51VDCRLHFGVE ILNADAHAVE AESAEHEDGV AADFARVDFD GIFAGRYQFE 101MFADHAEDTF DLFVAQKGRR AAAEVQLGKL VPSVQMWSEQ FHFFFKIFDV 151GIGAAFVFGD DFVAAAVVAD GVAKRNVNVK GKRFV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 783>:

m221.seq 1 ATGGyGGTTT TGATGcwcmg AAGTCTGGTG CGGCAGGCCG TAAATCAAAT 51CGACGCTGAC GGATTTGAAC CCCGCTTCGC GCGCCGCATC GATGACTTCT 101TTGGTTTCTT CGTAACTTTG GATGCGGTTG ACCGCCGCCT GCACTTTGGG 151GTCGAAATCC TGAATGCCGA TGCTCATGCG GTTGAAGCCG AGTCTGCCGA 201GCATGAGGAC GGTGTCGCGG CTGACTTTGC GCGGGTCGAT TTCGATGGAG 251TATTCGCCGG TGGGGATTAA CTCGAAATGT TTGCGTATCA TGCGGAAGAC 301ACGTTCGATC TGTTCGTCGC TCAAAAAGGt GCGTGCcCCG CCGAAGTGCA 351GTTGGGCAAG CTGGTGCCGT CCGTTCAGAT GTGGAGCGAG CAGTTCCATT 401TCTTTTTCAA GATATTCGAT GTAGGCATCG GCGCGGCTTT TGTCTTTGGT 451GATGATTTTG TTGCAGCCGC AGTAGTAGCA GATGGTGTTG CAGAACGGAA 501TGTGAATGTA AAGGGAAAGC GGTTTGTTTA AThis corresponds to the amino acid sequence <SEQ ID 784; ORF 221>:

m221.pep 1 MXVLMXRSLV RQAVNQIDAD GFEPRFARRI DDFFGFFVTL DAVDRRLHFG 51VEILNADAHA VEAESAEHED GVAADFARVD FDGVFAGGDX LEMFAYHAED 101 TFDLFVAQKGACPAEVQLGK LVPSVQMWSE QFHFFFKIFD VGIGAAFVFG 151 DDFVAAAVVA DGVAERNVNVKGKRFV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 221 shows 87.6% identity over a 170 aa overlap with a predicted ORF(ORF 221.ng) from N. gonorrhoeae:

m221/g221                 10        20        30        40        50m221.pep         MXVLMXRSLVRQAVNQIDADGFEPRFARRIDDFFGFFVTLDAVDRRLHFGVE               ||:|:||| |||||||| ::  |||||||||:||||| ||||||| g221MHDHGAMDRRLPAFGSLMRRAVNXIDADGFEPCLTGGIDDFFGFFVALDAVDCRLHFGVE        10        20        30        40        50        60      60        70        80        90       100       110 m221.pepILNADAHAVEAESAEHEDGVAADFARVDFDGVFAGGDXLEMFAYHAEDIFDLFVAQKGA-|||||||||||||||||||||||||||||||:|||   :|||| |||||||||||||| g221ILNADAHAVEAESAEHEDGVAADFARVDFDGIFAGRYQFEMFADHAEDTFDLFVAQKGRR        70        80        90       100       110       120      120       130       140       150       160       170 m221.pepCPAEVQLGKLVPSVQMWSEQFHFFFKIFDVGIGAAFVFGDDFVAAAVVADGVAERNVNVK  |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||| g221AAAEVQLGKLVPSVQMWSEQFHFFFKIFDVGIGAAFVFGDDFVAAAVVADGVAKRNVNVK       130       140       150       160       170       180 m221.pepGKRFVX |||||| g221 GKRFVXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 785>:

a221.seq 1 ATGGTGGTTT TGATGCTCCG AAGTCTGGTG CGGCAGGCCG TAAATCAAAT 51CGACGCTGAC GGATTTGAAC CCCGCTTCGC GCGCCGCATC GATGACTTCT 101 TTGGTTTCTTCGTAACTTTG GATGCGGTTG ACCGCCGCCT GCACTTTGGG 151 GTCGAAATCC TGAATGCCGATGCTCATGCG GTTGAAGCCG AGTCTGCCGA 201 GCATGAGGAC GGTGTCGCGG CTGACTTTGCGCGGGTCGAT TTCGATGGAG 251 TATTCGCCGG TGGGGATTAA CTCGAAATGT TTGCGTATCATGCGGAAGAC 301 ACGTTCGATT TGGTCGTCGC TCAAAAAGGT CGGCGTGCCG CCGCCGAAGT351 GCAGTTGGGC AAGCTGGTGC CGTCCGTTCA GATGTGGAGC GAGCAGTTCC 401ATTTCTTTTT CAAGAAATTC GATGTAGGCA TCGGCGCGGC TTTTGTCTTT 451 GGTGATGATTTTGTTGCAGC CGCAGTAGTA GCAGATGGTG TTGCAGAACG 501 GAATGTGAAT GTAAAGGGAAAGCGGTTTGT TTAAThis corresponds to the amino acid sequence <SEQ ID 786; ORF 221.a>:

a221.pep 1 MVVLMLRSLV RQAVNQIDAD GFEPRFARRI DDFFGFFVTL DAVDRRLHFG 51VEILNADAHA VEAESAEHED GVAADFARVD FDGVFAGGD* LEMFAYHAED 101 TFDLVVAQKGRRAAAEVQLG KLVPSVQMWS EQFHFFFKKF DVGIGAAFVF 151 GDDFVAAAVV ADGVAERNVNVKGKRFV* m221/a221 95.5% identity in 177 aa overlap          10        20        30        40        50        60 m221.pep  MXVLMXRSLVRQAVNQIDADGFEPRFARRIDDFFGFFVTLDAVDRRLHFGVEILNADAHA  | ||| |||||||||||||||||||||||||||||||||||||||||||||||||||||| a221  MVVLMLRSLVRQAVNQIDADGFEPRFARRIDDFFGFFVTLDAVDRRLHFGVEILNADAHA          10        20        30        40        50        60          70        80        90       100       110       119 m221.pep  VEAESAEHEDGVAADFARVDFDGVFAGGDXLEMFAYHAEDTFDLFVAQKGA-CPAEVQLG  |||||||||||||||||||||||||||||||||||||||||||| |||||    |||||| a221  VEAESAEHEDGVAADFARVDFDGVFAGGDXLEMFAYHAEDTFDLVVAQKGRRAAAEVQLG          70        80        90       100       110       120120       130       140       150       160       170 m221.pep  KLVPSVQMWSEQFHFFFKIFDVGIGAAFVFGDDFVAAAVVADGVAERNVNVKGKRFVX  |||||||||||||||||| ||||||||||||||||||||||||||||||||||||||| a221  KLVPSVQMWSEQFHFFFKKFDVGIGAAFVFGDDFVAAAVVADGVAERNVNVKGKRFVX         130       140       150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 787>:

g223.seq 1 atggaattca ggcaccaggt agtggtagtt ggtgtcgaac catttggtca 51tttcgatggc gaattggtct ttgttgccgc gcgccagttg gaagaattgt 101 tccaaaggcaggttttggct atcgaagccg aaacgggcgg gaatcgcgcc 151 cgtggatact tgcaggtcgaggatgtgatg gtagaaagtg aaatcacgta 201 cagcaacgta atcagcgtta ggagcagcttggtgtttcca gtttttctcg 251 cgcaggtctt tggcaacgtc gagcagctct tgttcactgatctctttgcg 301 ccagtatttt tcttgggcga atttcaattc acggaaggcg ccgacacgcg351 ggaagcctgaThis corresponds to the amino acid sequence <SEQ ID 788; ORF 223.ng>:

g223.pep.. 1 MEFRHQVVVV GVEPFGHFDG ELVFVAARQL EELFQRQVLA IEAETGGNRA 51RGYLQVEDVM VESEITYSNV ISVRSSLVFP VFLAQVFGNV EQLLFTDLFA 101 PVFFLGEFQFTEGADTREA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 789>:

m223.seq 1 GTGGAATTCA GGCACCAAGT AGTGGTAGTT GGTGTCGAAC CATTTGGTCA 51TTTCGATAGC GAATTGGTCT TTGTTACCGC GCGCCAGTTG GAAGAATTGT 101 TCCAAAGACAGGTTTTGGCT GTCGAAGCCG AAGCGGGCGG GAATCGCGCC 151 GGTGGCGACT TGCAGGTCGAGGATGTGGTC GTAGAAAGTG AAATCsCTAC 201 GGCAACGAAA TCGGCGTTGG CAGCGACCTGGTGTTTCCAG TTTTTCTCGC 251 GCAAGTCTTT AGCAACAGCC AGCAATTCTT GCTCGCTGATTTCTTTGCGC 301 CAGTATTTTT CTTGTGCGAA TTTCAATTCG CGGAAGGCGC CGACACGCGG351 GAAGCCTGAThis corresponds to the amino acid sequence <SEQ ID 790; ORF 223>:

m223.pep 1 VEFRHQVVVV GVEPFGHFDS ELVFVTARQL EELFQRQVLA VEAEAGGNRA 51GGDLQVEDVV VESEIXYGNE IGVGSDLVFP VFLAQVFSNS QQFLLADFFA 101 PVFFLCEFQFAEGADTREA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 223 shows 80.7% identity over a 119 aa overlap with a predicted ORF(ORF 223.ng) from N. gonorrhoeae:

m223/g223         10        20        30        40        50        60m223.pep VEFRHQVVVVGVEPFGHFDSELVFVTARQLEELFQRQVLAVEAEAGGNRAGGDLQVEDVV:||||||||||||||||||:|||||:||||||||||||||:|||:||||| | ||||||: g223MEFRHQVVVVGVEPFGHFDGELVFVAARQLEELFQRQVLAIEAETGGNRARGYLQVEDVM        10        20        30        40        50        60        70        80        90       100       110       120 m223.pepVESEIXYGNEIGVGSDLVFPVFLAQVFSNSQQFLLADFFAPVFFLCEFQFAEGADTREAX|||||:|:| |:| |:|||||||||||:| :|:|::|:||||||| ||||:||||||||| g223VESEITYSNVISVRSSLVFPVFLAQVFGNVEQLLFTDLFAPVFFLGEFQFTEGADTREAX        70        80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 791>:

a223.seq 1 GTGGAATTCA GGCACCAAGT AGTGGTAGTT GGTGTCGAAC CATTTGGTCA 51TTTCGATAGC GAATTGGTCT TTGTTACCGC GCGCCAGTTG GAAGAATTGT 101 TCCAAAGATAGGTTTTGGCT GTCGAAGCCG AAGCGGGCGG GAATCGCGCC 151 GGTGGCGACT TGCAGGTCGAGGATGTGGTC GTAGAAAGTG AAATCGCCTA 201 CGGCAACGTA ATCGGCGTTG GCAGCGGCCTGGTGTTTCCA GTTTTTCTCG 251 CGCAAGTCTT TAGCAACAGC CAGCAATTCT TGCTCGCTGATTTCTTTGCG 301 CCAGTATTTT TCTTGTGCGA ATTTCAATTC GCGGAAGGCA CCGACACGCG351 GGAAGCCTGAThis corresponds to the amino acid sequence <SEQ ID 792; ORF 223.a>:

a223.pep 1 VEFRHQVVVV GVEPFGHFDS ELVFVTARQL EELFQR*VLA VEAEAGGNRA 51GGDLQVEDVV VESEIAYGNV IGVGSGLVFP VFLAQVFSNS QQFLLADFFA 101 PVFFLCEFQFAEGTDTREA* m223/a223 95.8% identity in 119 aa overlap        10        20        30        40        50        60 m223.pepVEFRHQVVVVGVEPFGHFDSELVFVTARQLEELFQRQVLAVEAEAGGNRAGGDLQVEDVV|||||||||||||||||||||||||||||||||||| ||||||||||||||||||||||| a223VEFRHQVVVVGVEPFGHFDSELVFVTARQLEELFQRXVLAVEAEAGGNRAGGDLQVEDVV        10        20        30        40        50        60        70        80        90       100       110       120 m223.pepVESEIXYGNEIGVGSDLVFPVFLAQVFSNSQQFLLADFFAPVFFLCEFQFAEGADTREAX||||| ||| ||||| |||||||||||||||||||||||||||||||||||||:|||||| a223VESEIAYGNVIGVGSGLVFPVFLAQVFSNSQQFLLADFFAPVFFLCEFQFAEGTDTREAX        70        80        90       100       110       120The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 793>:

g225.seq 1 atggattctt ttttcaaacc ggcagtttgg gcggttttgt ggctgatgtt 51tgccgtccgc cccgcccttg ccgacgagtt gaccaacctg ctcagcagcc 101 gcgagcagattctcagacag tttgccgaag acgaacagcc cgttttaccc 151 gtcaaccgag cccccgcccggcgggcgggc aatgccgacg aactcatcgg 201 cggcgcgatg gggcttaacg aacagcccgttgtacgcgtc aaccgagccn 251 ccgcccggcg ggcgggcaat gccgacaaac tcatcggcagcgcgatgcgg 301 cttttgggta ttgcctaccg ctacggcggc acatcggtgt ctaccggttt351 tgactgcagc ggattcatgc agcacatctt caaacgcgcc atgggcatca 401acctgccgcg cacgtcggcg gaacaggcgc ggatgggcgc acccgttgcc 451 cgaagcgaattgcagcccgg ggatatggtg tttttccgca cgctcggcgg 501 cagccgcatt tcccatgtcggactttatat cggcaacaac cgcttcatcc 551 acgcgccgcg cacggggaaa aatatcgaaatcaccagcct gagccacaaa 601 tattggagcg gcaaatatgc gttcgcccgc cgggtcaagaaaaacgaccc 651 gtcacgcttt ctgaactgaThis corresponds to the amino acid sequence <SEQ ID 794; ORF 225.ng>:

g225.pep 1 MDSFFKPAVW AVLWLMFAVR PALADELTNL LSSREQILRQ FAEDEQPVLP 51VNRAPARRAG NADELIGGAM GLNEQPVVRV NRAXARRAGN ADKLIGSAMR 101 LLGIAYRYGGTSVSTGFDCS GFMQHIFKRA MGINLPRTSA EQARMGAPVA 151 RSELQPGDMV FFRTLGGSRISHVGLYIGNN RFIHAPRTGK NIEITSLSHK 201 YWSGKYAFAR RVKKNDPSRF LN*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 795>:

m225.seq (partial) 1 ..TTTTCAAACC CGGCAGTTTG GGCGGTTTTG TGGCTGAwGTTTGCCGTCCG 51   CCCCGCCCTT GCCGACGAGT TGACCAACCT GCTCAGCAGC CGCGAGCAGA101   TTCTCAGACA GTTTGCCGAA GACGAACAGC CCGTTTTACC CATCAACCGA 151  GCCCCCGCCC GGCGGGCGGG CAATGCCGAC GAACTCATCG GCAGCGCGAT 201  GGGGCTTAAC GAACAGCCCG TTTTACCCGT CAACCGAGTC CCCGCCCGGC 251  GGGCGGGCAA TGCCGACGAA CTCATCGGCA ACGCGATGGG GCTTAACGAA 301  CAGCCCGTTT TACCCGTCAA CCGAGCCCCC GCCCGGCGGG CGGGCAATGC 351  CGACGAACTC ATCGGCAACG CGATGGGACT TTTGGGTATT GCCTACCGCT 401  ACGGCGGCAC ATCGGTTTCT ACCGGTTTTG ACTGCAGCGG CTTCATGCAG 451  CACATCTTCA AACGCGCCAT GGGCATCAAC CTGCCGCGCA CGTCGGCAGA 501  ACAGGCACGG ATGGGTACGC CGGTTGCCCG AAGCGAATTG CAGCCCGGAG 551  ATATGGTGTT TTTCCGCACG CTCGGCGGCA GCCGCATTTC CCATGTCGGA 601  CTTTATATCG GCAACAACCG CTTCATCCAC GCGCCGCGCA CGGGGAAAAA 651  TATCGAAATC ACCAGCCTGA GCCACAAATA TTGGAGCGGC AAATACGCGT 701  TCGCCCGCCG GGTCAAGAAA AACGACCCGT CCCGCTTTCT GAACTGAThis corresponds to the amino acid sequence <SEQ ID 796; ORF 225>:

m225.pep (partial) 1 ..FSNPAVWAVL WLXFAVRPAL ADELTNLLSS REQILRQFAEDEQPVLPINR 51   APARRAGNAD ELIGSAMGLN EQPVLPVNRV PARRAGNADE LIGNAMGLNE101   QPVLPVNRAP ARRAGNADEL IGNAMGLLGI AYRYGGTSVS TGFDCSGFMQ 151  HIFKRAMGIN LPRTSAEQAR MGTPVARSEL QPGDMVFFRT LGGSRISHVG 201  LYIGNNRFIH APRTGKNIEI TSLSHKYWSG KYAFARRVKK NDPSRFLN*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 225 shows 83.5% identity over a 248 aa overlap with a predicted ORF(ORF 225.ng) from N. gonorrhoeae:

m225/g225            10        20        30        40        50 m225.pep   FSNPAVWAVLWLXFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAG   | :||||||||| ||||||||||||||||||||||||||||||||||:||||||||| g225MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPVNRAPARRAG        10        20        30        40        50        60 60        70        80        90       100       110 m225.pepNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNA|||||||                             :|||||||||: |||| ||||||| g225NADELIG-----------------------------GAMGLNEQPVVRVNRAXARRAGNA                                     70        80        90120       130       140       150       160       170 m225.pepDELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVAR|:|||:|| ||||||||||||||||||||||||||||||||||||||||||||||:|||| g225DKLIGSAMRLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGAPVAR      100       110       120       130       140       150180       190       200       210       220       230 m225.pepSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g225SELQPGDMVFFRILGGSRISHVGLYIGNNRFIHAPRIGKNIEITSLSHKYWSGKYAFARR      160       170       180       190       200       210 240      249m225.pep VKKNDPSRFLNX ||||||||||| g225 VKKNDPSRFLN       220The following partial DNA sequence was identified in N. meningitidis<SEQ ID 797>:

a225.seq 1 ATGGATTCTT TTTTCAAACC GGCAGTTTGG GCGGTTTTGT GGCTGATGTT 51TGCCGTCCGC CCCGCCCTTG CCGACGAGTT GACCAACCTG CTCAGCAGCC 101 GCGAGCAGATTCTCAGACAG TTTGCCGAAG ACGAACAGCC CGTTTTACCC 151 ATCAACCGAN CCCCCGCCCGGCGGGCGGGC AATGCCGACG AACTCATCGG 201 CAGCGCGATG GGGCTTAACG AACAGCCCGTTTTACCCGTC AACCGANTCC 251 CCGCCCGGCG GGCGGGCAAT GCCGACNAAC TCATCGGCAACGCGATGGGG 301 CTTAACGAAC AGCCCGTTTT ACCCGTCAAC CGAGTCCCCG CCCGGCGGGC351 GGGCAATGCC GACGAACTCA TCGGCAACGC GATGGGGCTT AACGAACAGC 401CCGTTTTACC CGTCAACCGA GCCCCCGCCC GGCGGGCGGG CAATGCCGAC 451 GAACTCATCGGCAACGCGAT GGGACTTTTG GGTATTGCCT ACCGCTACGG 501 CGGCACATCG ATTTCTACCGGTTTTGACTG CAGCGGCTTC ATGCAGCACA 551 TCTTCAAACG CGCCATGGGC ATCAACCTGCCGCGCACGTC GGCAGAACAG 601 GCGCGGATGG GTACGCCGGT TGCCCGAAGC GAATTGCAGCCCGGGGATAT 651 GGTGTNTTTC CGCACGCTCG GCGGCAGCCG CATTTCCCAT GTCGGACTTT701 ATATCGGCAA CAACCGCTTC ATCCACGCGC CGCGCACGGG GAAAAATATC 751GAAATCACCA GCCTGAGCCA CAAATATTGG AGCGGCAAAT ACGCGTTCGC 801 CCGCCGGGTCAAGAAAAACG ACCCGTCCCG CTTTCTGAAC TGAThis corresponds to the amino acid sequence <SEQ ID 798; ORF 225.a>:

a225.pep 1 MDSFFKPAVW AVLWLMFAVR PALADELTNL LSSREQILRQ FAEDEQPVLP 51INRXPARRAG NADELIGSAM GLNEQPVLPV NRXPARRAGN ADXLIGNAMG 101 LNEQPVLPVNRVPARRAGNA DELIGNAMGL NEQPVLPVNR APARRAGNAD 151 ELIGNAMGLL GIAYRYGGTSISTGFDCSGF MQHIFKRAMG INLPRTSAEQ 201 ARMGTPVARS ELQPGDMVXF RTLGGSRISHVGLYIGNNRF IHAPRTGKNI 251 EITSLSHKYW SGKYAFARRV KKNDPSRFLN * m225/a22587.4% identity in 277 aa overlap            10        20        30        40        50 m225.pep    FSNPAVWAVLWLXFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAG    | :||||||||| ||||||||||||||||||||||||||||||||||||| |||||| a225 MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRXPARRAG         10        20        30        40        50        60  60        70       79                            80 m225.pep NADELIGSAMGLNEQPVLPVNR-----------------------------VPARRAGNA ||||||||||||||||||||||                             ||||||||| a225 NADELIGSAMGLNEQPVLPVNRXPARRAGNADXLIGNAMGLNEQPVLPVNRVPARRAGNA         70        80        90       100       110       120 90       100       110       120       130       140 m225.pep DELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGF ||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| a225 DELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGF        130       140       150       160       170       180150       160       170       180       190       200 m225.pep MQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFFRTLGGSRISHVGLYIGNNRF |||||||||||||||||||||||||||||||||||||| ||||||||||||||||||||| a225 MQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVXFRTLGGSRISHVGLYIGNNRF        190       200       210       220       230       240210       220       230       240      249 m225.pep IHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFLNX ||||||||||||||||||||||||||||||||||||||||| a225 IHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFLNX        250       260       270       280The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 799>:

g225-1.seq 1 atggattctt ttttcaaacc ggcagtttgg gcggttttgt ggctgatgtt 51tgccgtccgc cccgcccttg ccgacgagtt gaccaacctg ctcagcagcc 101 gcgagcagattctcagacag tttgccgaag acgaacagcc cgttttaccc 151 gtcaaccgag cccccgcccggcgggcgggc aatgccgacg aactcatcgg 201 cggcgcgatg gggcttaacg aacagcccgttgtacgcgtc aaccgagccn 251 ccgcccggcg ggcgggcaat gccgacaaac tcatcggcagcgcgatgcgg 301 cttttgggta ttgcctaccg ctacggcggc acatcggtgt ctaccggttt351 tgactgcagc ggattcatgc agcacatctt caaacgcgcc atgggcatca 401acctgccgcg cacgtcggcg gaacaggcgc ggatgggcgc acccgttgcc 451 cgaagcgaattgcagcccgg ggatatggtg tttttccgca cgctcggcgg 501 cagccgcatt tcccatgtcggactttatat cggcaacaac cgcttcatcc 551 acgcgccgcg cacggggaaa aatatcgaaatcaccagcct gagccacaaa 601 tattggagcg gcaaatatgc gttcgcccgc cgggtcaagaaaaacgaccc 651 gtcacgcttt ctgaactgaThis corresponds to the amino acid sequence <SEQ ID 800; ORF 225-1.ng>:

g225-1.pep 1 MDSFFKPAVW AVLWLMFAVR PALADELTNL LSSREQILRQ FAEDEQPVLP 51VNRAPARRAG NADELIGGAM GLNEQPVVRV NRAXARRAGN ADKLIGSAMR 101 LLGIAYRYGGTSVSTGFDCS GFMQHIFKRA MGINLPRTSA EQARMGAPVA 151 RSELQPGDMV FFRTLGGSRISHVGLYIGNN RFIHAPRTGK NIEITSLSHK 201 YWSGKYAFAR RVKKNDPSRF LN*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 801>:

m225-1.seq 1 ATGGATTCTT TTTTCAAACC GGCAGTTTGG GCGGTTTTGT GGCTGATGTT 51TGCCGTCCGC CCCGCCCTTG CCGACGAGTT GACCAACyTG CTCAGCAGCC 101 GCGAGCAGATTCTCAGACAG TTTGCCGAAG ACGAACAGCC CGTTTTACCC 151 ATCAACCGAG CCCCCGCCCGGCGGGCGGGC AATGCCGACG AACTCATCGG 201 CAGCGCGATG GGGCTTAACG AACAGCCCGTTTTACCCGTC AACCGAGTCC 251 CCGCCCGGCG GGCGGGCAAT GCCGACGAAC TCATCGGCAACGCGATGGGG 301 CTTAACGAAC AGCCCGTTTT ACCCGTCAAC CGAGCCCCCG CCCGGCGGGC351 GGGCAATGCC GACGAACTCA TCGGCAACGC GATGGGACTT TTGGGTATTG 401CCTACCGCTA CGGCGGCACA TCGGTTTCTA CCGGTTTTGA CTGCAGCGGC 451 TTCATGCAGCACATCTTCAA ACGCGCCATG GGCATCAACC TGCCGCGCAC 501 GTCGGCAGAA CAGGCACGGATGGGTACGCC GGTTGCCCGA AGCGAATTGC 551 AGCCCGGAGA TATGGTGTTT TTCCGCACGCTCGGCGGCAG CCGCATTTCC 601 CATGTCGGAC TTTATATCGG CAACAACCGC TTCATCCACGCGCCGCGCAC 651 GGGGAAAAAT ATCGAAATCA CCAGCCTGAG CCACAAATAT TGGAGCGGCA701 AATACGCGTT CGCCCGCCGG GTCAAGAAAA ACGACCCGTC CCGCTTTCTG 751 AACTGAThis corresponds to the amino acid sequence <SEQ ID 802; ORF 217>:

m225-1.pep 1 MDSFFKPAVW AVLWLMFAVR PALADELTNL LSSREQILRQ FAEDEQPVLP 51INRAPARRAG NADELIGSAM GLNEQPVLPV NRVPARRAGN ADELIGNAMG 101 LNEQPVLPVNRAPARRAGNA DELIGNAMGL LGIAYRYGGT SVSTGFDCSG 151 FMQHIFKRAM GINLPRTSAEQARMGTPVAR SELQPGDMVF FRTLGGSRIS 201 HVGLYIGNNR FIHAPRTGKN IEITSLSHKYWSGKYAFARR VKKNDPSRFL 251 N* m225-1/g225-1 84.9% identity in 251 aaoverlap         10        20        30        40        50        60m225-1.pep MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAG||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| g225-1MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPVNRAPARRAG        10        20        30        40        50        60        70        80        90       100       110       120 m225-1.pepNADELIGSAMGLNEQPVLPVNRVPARRAGNADELIGNAMGLNEQPVLPVNRAPARRAGNA||||                             |||:|||||||||: |||| ||||||| g225-1NADE-----------------------------LIGGAMGLNEQPVVRVNRAXARRAGNA                                     70        80        90       130       140       150       160       170       180 m225-1.pepDELIGNAMGLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGTPVAR|:|||:|| ||||||||||||||||||||||||||||||||||||||||||||||:|||| g225-1DKLIGSAMRLLGIAYRYGGTSVSTGFDCSGFMQHIFKRAMGINLPRTSAEQARMGAPVAR      100       110       120       130       140       150       190       200       210       220       230       240 m225-1.pepSELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g225-1SELQPGDMVFFRTLGGSRISHVGLYIGNNRFIHAPRTGKNIEITSLSHKYWSGKYAFARR      160       170       180       190       200       210        250m225-1.pep VKKNDPSRFLNX |||||||||||| g225-1 VKKNDPSRFLNX       220The following partial DNA sequence was identified in N. meningitidis<SEQ ID 803>:

a225-1.seq 1 ATGGATTCTT TTTTCAAACC GGCAGTTTGG GCGGTTTTGT GGCTGATGTT 51TGCCGTCCGC CCCGCCCTTG CCGACGAGTT GACCAACCTG CTCAGCAGCC 101 GCGAGCAGATTCTCAGACAG TTTGCCGAAG ACGAACAGCC CGTTTTACCC 151 ATCAACCGAN CCCCCGCCCGGCGGGCGGGC AATGCCGACG AACTCATCGG 201 CAGCGCGATG GGGCTTAACG AACAGCCCGTTTTACCCGTC AACCGANTCC 251 CCGCCCGGCG GGCGGGCAAT GCCGACNAAC TCATCGGCAACGCGATGGGG 301 CTTAACGAAC AGCCCGTTTT ACCCGTCAAC CGAGTCCCCG CCCGGCGGGC351 GGGCAATGCC GACGAACTCA TCGGCAACGC GATGGGGCTT AACGAACAGC 401CCGTTTTACC CGTCAACCGA GCCCCCGCCC GGCGGGCGGG CAATGCCGAC 451 GAACTCATCGGCAACGCGAT GGGACTTTTG GGTATTGCCT ACCGCTACGG 501 CGGCACATCG ATTTCTACCGGTTTTGACTG CAGCGGCTTC ATGCAGCACA 551 TCTTCAAACG CGCCATGGGC ATCAACCTGCCGCGCACGTC GGCAGAACAG 601 GCGCGGATGG GTACGCCGGT TGCCCGAAGC GAATTGCAGCCCGGGGATAT 651 GGTGTNTTTC CGCACGCTCG GCGGCAGCCG CATTTCCCAT GTCGGACTTT701 ATATCGGCAA CAACCGCTTC ATCCACGCGC CGCGCACGGG GAAAAATATC 751GAAATCACCA GCCTGAGCCA CAAATATTGG AGCGGCAAAT ACGCGTTCGC 801 CCGCCGGGTCAAGAAAAACG ACCCGTCCCG CTTTCTGAAC TGAThis corresponds to the amino acid sequence <SEQ ID 804; ORF 225-1.a>:

a225-1.pep 1 MDSFFKPAVW AVLWLMFAVR PALADELTNL LSSREQILRQ FAEDEQPVLP 51INRXPARRAG NADELIGSAM GLNEQPVLPV NRXPARRAGN ADXLIGNAMG 101 LNEQPVLPVNRVPARRAGNA DELIGNAMGL NEQPVLPVNR APARRAGNAD 151 ELIGNAMGLL GIAYRYGGTSISTGFDCSGF MQHIFKRAMG INLPRTSAEQ 201 ARMGTPVARS ELQPGDMVXF RTLGGSRISHVGLYIGNNRF IHAPRTGKNI 251 EITSLSHKYW SGKYAFARRV KKNDPSRFLN *a225-1/m225-1 88.6% identity in 280 aa overlap        10        20        30        40        50        60 a225-1.pepMDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRXPARRAG||||||||||||||||||||||||||||||||||||||||||||||||||||| |||||| m225-1MDSFFKPAVWAVLWLMFAVRPALADELTNLLSSREQILRQFAEDEQPVLPINRAPARRAG        10        20        30        40        50        60        70        80        90       100       110       120 a225-1.pepNADELIGSAMGLNEQPVLPVNRXPARRAGNADXLIGNAMGLNEQPVLPVNRVPARRAGNA||||||||||||||||                             ||||||||||||||| m225-1NADELIGSAMGLNEQP-----------------------------VLPVNRVPARRAGNA        70                                     80        90       130       140       150       160       170       180 a225-1.pepDELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSISTGFDCSGF||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| m225-1DELIGNAMGLNEQPVLPVNRAPARRAGNADELIGNAMGLLGIAYRYGGTSVSTGFDCSGF      100       110       120       130       140       150       190       200       210       220       230       240 a225-1.pepMQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVXERTLGGSRISHVGLYIGNNRF|||||||||||||||||||||||||||||||||||||| ||||||||||||||||||||| m225-1MQHIFKRAMGINLPRTSAEQARMGTPVARSELQPGDMVFERTLGGSRISHVGLYIGNNRF      160       170       180       190       200       210       250       260       270       280 a225-1.pepIHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFLNX||||||||||||||||||||||||||||||||||||||||| m225-1IHAPRTGKNIEITSLSHKYWSGKYAFARRVKKNDPSRFLNX      220       230       240       250The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 805>:

g226.seq 1 ATGAGCGAAA TCCTCAGGCA GCCCAGCGTT CTGCTTTTCC TCACGCTTGC 51CGTGTACGCG CTTGCGATTA TCGTGCGCAC GCGCACGGGC AATATCTTCT 101 GCAACCCCGTACTCGTCAGC ACTATCGTGC TGATTGCCTA CCTGAAAATC 151 CTCGGTATCG ATTATGCGGTGTACCACAAC GCCGCGCAAT TCATTGATTT 201 TCGGCTGAAA cccGccgtCG TCGTGCTTGCCGTGCCGCTC TACCAAAACC 251 GCCGTAAAAT CTTCAACCAG TGGCTGCCCG TCATCGTTTCGCAGCTTGCG 301 GGCAGCGTTA cggGCATTGT tacggggATG TATTTTgccg cttggctcgg351 gccggatacc caattctcct tcccgcctcg tcttcaatat ctgttattta 401caccctctgg aatcccaatt cacaccctgt atgcgcgggt tctcccgcca 451 tttctgttgcctccgcctct cctgccgcgc ctcggcccgc atacattgcg 501 ccggttcaca atacttccaaaaaaactacg gccgtttaag cccctcctcc 551 cagttgtggt cctttctcct Ccgggcctcgcccctcccct cttataaThis corresponds to the amino acid sequence <SEQ ID 806; ORF 226.ng>:

g226.pep 1 MSEILRQPSV LLFLTLAVYA LAIIVRTRTG NIFCNPVLVS TIVLIAYLKI 51LGIDYAVYHN AAQFIDFRLK PAVVVLAVPL YQNRRKIFNQ WLPVIVSQLA 101 GSVTGIVTGMYFAAWLGPDT QFSFPPRLQY LLFTPSGIPI HTLYARVLPP 151 FLLPPPLLPR LGPHTLRRFTILPKKLRPFK PLLPVVVLSP PGLAPPLL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 807>:

m226.seq 1 ATGAACGAAA TCCTCAGGCA GCCCAGCGTT CTGCTTTTCC TCACGCTTGC 51CGTGTACGCG CTTGCGATTA TCGtGCGCAC GCGCACGGGC AATATCTTCT 101 GCAACCCCGTACTCGTCAGC ACTATCGTGC TGATTGCCTA CCTGAAAATC 151 CTCGGTATCG ATTATGCGGTGTACCACAAC GCCGCGCAAT TCATTGATTT 201 TTGGCTGAAA CCCGCCGTCG TCGTGCTTGCCGTGCCGCTC TACCAAAACC 251 GCCGTAAAAT CTTCAACCAG TGGCTGCCCG TCATCGTTTCACAGCTTGCG 301 GGCAGCGTTA CGGGCATTGT TACAGGGATG TATTTTGCCA AATGGCTGGG351 CGCGGAACGC GAAGTCGTCC TCTCGCTCGC GTCCAAATCT GTTACCAACC 401CCATCGCTAT TGAAATCACC CGCTCCATCG GCGGCATTCC CGCCATTACC 451 GCCGCCACCGTCATCATTGC CGGTCTGGTC GGACAGATTG CCGGTTACAA 501 AATGCTGAAG AACACGGTCGTCATGCCCTC GTCCGTGGGT ATGTCGCTCG 551 GCACGGCTTC GCACGCGATG GGGATTGCCGCCTCGCTCGA ACGCAGCCGC 601 CGTATGGCGG CATACGCGGG GCTGGGGCTG ACGTTCAACGGCGTACTGAC 651 CGCGCTGATT GCGCCGCTGC TCATCCCCGT TTTGGGATTT TGAThis corresponds to the amino acid sequence <SEQ ID 808; ORF 226>:

m226.pep 1 MNEILRQPSV LLFLTLAVYA LAIIVRTRTG NIFCNPVLVS TIVLIAYLKI 51LGIDYAVYHN AAQFIDFWLK PAVVVLAVPL YQNRRKIFNQ WLPVIVSQLA 101 GSVTGIVTGMYFAKWLGAER EVVLSLASKS VTNPIAIEIT RSIGGIPAIT 151 AATVIIAGLV GQIAGYKMLKNTVVMPSSVG MSLGTASHAM GIAASLERSR 201 RMAAYAGLGL TFNGVLTALI APLLIPVLGF *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 226 shows 94.2% identity over a 121 aa overlap with a predicted ORF(ORF 226.ng) from N. gonorrhoeae:

m226/g226         10        20        30        40        50        60m226.pep MNEILRQPSVLLFLTLAVYALAIIVRTRTGNIFCNPVLVSTIVLIAYLKILGIDYAVYHN|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g226MSEILRQPSVLLFLTLAVYALAIIVRTRIGNIFCNPVLVSTIVLIAYLKILGIDYAVYHN        10        20        30        40        50        60        70        80        90        100        110        120 m226.pepAAQFIDFWLKPAVVVLAVPLYQNRRKIFNQWLPVIVSQLAGSVTGIVTGMYFAKWLGAER||||||| ||||||||||||||||||||||||||||||||||||||||||||| ||| : g226AAQFIDFRLKPAVVVLAVPLYQNRRKIFNQWLPVIVSQLAGSVTGIVTGMYFAAWLGPDT        70        80        90       100       110       120       130       140       150       160       170       180 m226.pepEVVLSLASKSVTNPIAIEITRSIGGIPAITAATVIIAGLVGQIAGYKMLKNTVVMPSSVG : g226QFSFPPRLQYLLFTPSGIPIHTLYARVLPPFLLPPPLLPRLGPHTLRRFTILPKKLRPFK       130       140       150       160       170       180The following partial DNA sequence was identified in N. meningitidis<SEQ ID 809>:

a226.seq 1 ATGAACGAAA TCCTCAGGCA GCCGAGCATC CTGCTTTTCC TCACGCTTGC 51CGTGTACGCG CTTGCGATTA TCGTGCGCAC GCGCACGGGT AATATCTTCT 101 GCAACCCCGTACTCGTCAGC ACTATCGTGC TGATTGCCTA CCTGAAAATC 151 CTCGGTATCG ATTATGCGGTGTACCACAAC GCCGCGCAGT TTATCGATTT 201 CTGGCTCAAG CCCGCCGTCG TCGTGCTTGCCGTGCCGCTC TACCAAAACC 251 GCCGTAAAAT CTTCAACCAA TGGCTGCCCG TCATCGTTTCGCAGCTTGCG 301 GGCAGCGTTA CGGGCATTGT TACGGGGATG TATTTTGCCA AATGGCTGGG351 CGCGGAACGC GAAGTCGTCC TCTCGCTCGC GTCCAAATCT GTTACCAATC 401CTATCGCCAT CGAAATCACC CGCTCCATCG GCGGCATTCC CGCCATTACC 451 GCCGCCACCGTCATCATTGC CGGCCTGGTC GGACAGATTG CCGGTTACAA 501 AATGTTGAAA AACACGGTCGTTATGCCCTC ATCTGTCGGA ATGTCGCTCG 551 GCACGGCTTC GCACGCGATG GGCATTGCCGCCTCGCTCGA ACGCAGCCGC 601 CGCATGGCGG CATACGCGGG GCTGGGGCTG ACGTTCAACGGCGTACTGAC 651 CGCGCTGATT GCGCCGCTGC TTATCCCCGT TTTGGGATTT TGAThis corresponds to the amino acid sequence <SEQ ID 810; ORF 226.a>:

a226.pep 1 MNEILRQPSI LLFLTLAVYA LAIIVRTRTG NIFCNPVLVS TIVLIAYLKI 51LGIDYAVYHN AAQFIDFWLK PAVVVLAVPL YQNRRKIFNQ WLPVIVSQLA 101 GSVTGIVTGMYFAKWLGAER EVVLSLASKS VTNPIAIEIT RSIGGIPAIT 151 AATVIIAGLV GQIAGYKMLKNTVVMPSSVG MSLGTASHAM GIAASLERSR 201 RMAAYAGLGL TFNGVLTALI APLLIPVLGF *m226/a226 99.6% identity in 230 aa overlap        10        20        30        40        50        60 m226.pepMNEILRQPSVLLFLTLAVYALAIIVRTRTGNIFCNPVLVSTIVLIAYLKILGIDYAVYHN|||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||| a226MNEILRQPSILLFLTLAVYALAIIVRTRIGNIFCNPVLVSTIVLIAYLKILGIDYAVYHN        10        20        30        40        50        60        70        80        90       100       110       120 m226.pepAAQFIDFWLKPAVVVLAVPLYQNRRKIFNQWLPVIVSQLAGSVTGIVTGMYFAKWLGAER|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a226AAQFIDFWLKPAVVVLAVPLYQNRRKIFNQWLPVIVSQLAGSVTGIVTGMYFAKWLGAER        70        80        90       100       110       120       130       140       150       160       170       180 m226.pepEVVLSLASKSVTNPIAIEITRSIGGIPAITAATVIIAGLVGQIAGYKMLKNTVVMPSSVG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a226EVVLSLASKSVTNPIAIEITRSIGGIPAITAATVIIAGLVGQIAGYKMLKNTVVMPSSVG       130       140       150       160       170       180       190       200       210       220       230 m226.pepMSLGTASHAMGIAASLERSRRMAAYAGLGLTFNGVLTALIAPLLIPVLGFX||||||||||||||||||||||||||||||||||||||||||||||||||| a226MSLGTASHAMGIAASLERSRRMAAYAGLGLTFNGVLTALIAPLLIPVLGFX       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 811>:

g227.seq 1 atgaacatca tccgcgcgct cctcatcatc ctcggctgcc tcgccgccgg 51cgaaaccgcc gttttcctag caggcatcaa actgcccggc agcatcgtcg 101 gcatgggcgtgctgtttgcg cttttgcagg cgggttggct caaaacgtct 151 tggctgcaac agcttaccgacgcgctgatg gcaaacctga cgctgttcct 201 cgtgccgccc tgcgtggcgg tcatcagctatttggatttg attgccgacg 251 attggttttc gatactggtt tccgcctccg ccagcactttgtgcgtactg 301 ctggttacgg gcaaggttca ccgctggata cggagcatta tctgaThis corresponds to the amino acid sequence <SEQ ID 812; ORF 227.ng>:

g227.pep 1 MNIIRALLII LGCLAAGETA VFLAGIKLPG SIVGMGVLFA LLQAGWLKTS 51WLQQLTDALM ANLTLFLVPP CVAVISYLDL IADDWFSILV SASASTLCVL 101 LVTGKVHRWIRSII*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 813>:

m227.seq (partial) 1 ..ACGTCTTkGC TGCAACAGCT TACCGACGCG CTGATGTCGAACCTGACGCT 51   GTtCCTCGTG CCgCC.TGCG TGGCGGTCAT CAGCTATTTG GATTTGATTG101   CCGACGATTG GTTTTCGATA CTGGTTTCCG CCTCCGCCAG cACTTTGTGC 151  GTACTGCTGG TTACGGGCAA AGTCCACCGG TGGATACGGG GTATTATCCG 201   ATGAThis corresponds to the amino acid sequence <SEQ ID 814; ORF 227>:

m227.pep (partial) 1 ..TSXLQQLTDA LMSNLTLFLV PPCVAVISYLDLIADDWFSI LVSASASTLC 51   VLLVTGKVHR WIRGIIR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 227 shows 95.5% identity over a 66 aa overlap with a predicted ORF(ORF 227.ng) from N. gonorrhoeae:

m227/g227                                       10        20        30m227.pep                               TSXLQQLTDALMSNLTLFLVPPCVAVISYL                              || |||||||||:||||||||||||||||| g227TAVFLAGIKLPGSIVGMGVLFALLQAGWLKTSWLQQLTDALMANLTLFLVPPCVAVISYL        20        30        40        50        60        70        40        50        60 m227.pepDLIADDWFSILVSASASTLCVLLVTGKVHRWIRGIIRX|||||||||||||||||||||||||||||||||||| g227DLIADDWFSILVSASASTLCVLLVTGKVHRWIRSIIX 80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 815>:

a227.seq 1 ATGAACATCA TCCGCGCGCT CCTCATCATC CTCGGCTGCC TCGCCACCGG 51CGAAACCGCC GTTTTCCTAG CAGGCATCAA ACTGCCCGGC AGCATCGTCG 101 GCATGGGCGTACTGTTTGCG CTTTTGCAGG CGGGTTGGGT CAAAACGTCT 151 TGGCTGCAAC AGCTTACCGACGCGCTGATG GCGAATCTGA CGTTGTTTCT 201 CGTGCCGCCC TGCGTGGCGG TCATCAGCTATTTGGATTTG ATTGCCGACG 251 ATTGGTTTTC GATACTGGTT TCCGCCTCCG CCAGCACTTTGTGCGTACTG 301 CTGGTTACAG GCAAGGTTCA CCGCTGGATA CGGAGCATTA TCTGAThis corresponds to the amino acid sequence <SEQ ID 816; ORF 227.a>:

a227.pep 1 MNIIRALLII LGCLATGETA VFLAGIKLPG SIVGMGVLFA LLQAGWVKTS 51WLQQLTDALM ANLTLFLVPP CVAVISYLDL IADDWFSILV SASASTLCVL 101 LVTGKVHRWIRSII* m227/a227 95.5% identity in 66 aa overlap                                      10        20        30 m227.pep                              TSXLQQLTDALMSNLTLFLVPPCVAVISYL                              || |||||||||:||||||||||||||||| a227TAVFLAGIKLPGSIVGMGVLFALLQAGWVKISWLQQLTDALMANLTLFLVPPCVAVISYL20        30        40        50        60        70        40        50        60 m227.pepDLIADDWFSILVSASASTLCVLLVTGKVHRWIRGIIRX|||||||||||||||||||||||||||||||||:|| a227DLIADDWFSILVSASASTLCVLLVTGKVHRWIRSIIX 80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 817>:

m228.seq 1 ATGAAAAAAT TATTGATTGC CGCAATGATG GCGGCTGCCT TGGCAGCTTG 51TTCGCAAGAA GCCAAACAGG AGGTTAAGGA AGCGGTTCAA GCCGTTGAGT 101 CCGATGTTAAAGACACTGCG GCTTCTGCCG CCGAGTCTGC CGCTTCTGCC 151 GTCGAAGAAG CGAAAGACCAAGTCAAAGAT GCTGCGGCTG ATGCAAAGGC 201 AAGTGCCGAG GAAGCTGTAA CTGAAGCCAAAGAAGCTGTA ACTGAAGCAG 251 CTAAAGATAC TTTGAACAAA GCTGCCGACG CGACTCAGGAAGCGGCAGAC 301 AAAATGAAAG ATGCCGCCAA ATAAThis corresponds to the amino acid sequence <SEQ ID 818; ORF 228>:

m228.pep 1 MKKLLIAAMM AAALAACSQE AKQEVKEAVQ AVESDVKDTA ASAAESAASA 51VEEAKDQVKD AAADAKASAE EAVTEAKEAV TEAAKDTLNK AADATQEAAD 101 KMKDAAK*Computer analysis of this amino acid sequence gave the followingresults:The following partial DNA sequence was identified in N. meningitidis<SEQ ID 819>:

a228.seq 1 ATGAAAAAAT TATTGATTGC CGCAATGATG GCGGCTGCCT TGGCAGCTTG 51TTCGCAAGAA GCCAAACAGG AGGTTAAGGA AGCGGTTCAA GCCGTTGAGT 101 CCGATGTTAAAGACACTGCG GCTTCTGCCG CCGAGTCTGC CGCTTCTGCC 151 GTCGAAGAAG CGAAAGACCAAGTCAAAGAT GCTGCGGCTG ATGCAAAGGC 201 AAGTGCCGAG GAAGCTGTAA CTGAAGCCAAAGAAGCTGTA ACTGAAGCAG 251 CTAAAGATAC TTTGAACAAA GCTGCCGACG CGACTCAGGAAGCGGCAGAC 301 AAAATGAAAG ATGCCGCCAA ATAAThis corresponds to the amino acid sequence <SEQ ID 820; ORF 228.a>:

a228.pep 1 MKKLLIAAMM AAALAACSQE AKQEVKEAVQ AVESDVKDTA ASAAESAASA 51VEEAKDQVKD AAADAKASAE EAVTEAKEAV TEAAKDTLNK AADATQEAAD 101 KMKDAAK*m228/a228 100.0% identity in 107 aa overlap        10        20        30        40        50        60 m228.pepMKKLLIAAMMAAALAACSQEAKQEVKEAVQAVESDVKDTAASAAESAASAVEEAKDQVKD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a228MKKLLIAAMMAAALAACSQEAKQEVKEAVQAVESDVKDTAASAAESAASAVEEAKDQVKD        10        20        30        40        50        60        70        80        90       100 m228.pepAAADAKASAEEAVTEAKEAVTEAAKDTLNKAADATQEAADKMKDAAKX|||||||||||||||||||||||||||||||||||||||||||||||| a228AAADAKASAEEAVTEAKEAVTEAAKDTLNKAADATQEAADKMKDAAKX        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 821>:

g229.seq 1 atggctgccg tatcgggcgg cggtgcggtc ttcctgataa tgcttccaca 51tattgcccgc gttcagcgtc agccgccagc gttcgcccaa gcgtcgggag 101 aaatcggcattgaagccgcc ggcgaaattg tatcggctgc cgcccaagag 151 gttttgcccg acaaacggcacggtgccgaa cgagcgcgtt accgaacggt 201 tttgatggcc gaacgacagg cgcaggttctgttcgctgaa atctttgtta 251 tcccaataat gcacgccgcg gctgatgccg ccgtagaggaaatgatgccc 301 gcccgcattg atttcgcgcg acacgcccaa gccgtagcgc aaaccgtgtg351 ccttttgcgg caggctgtcg gcggttttcg tccagcttct gcccgcaaat 401tcaatcgttt tttcggacga agcgttgttt atagcggatt aacaaaaatc 451 aggacaaggcggcgggccgc aggcagtacg gatggtacgg aaccggttcg 501 cccggtgctt ggacgccttagggaaccgtt ccctttgagc cggggcgggg 551 caacccgtac cggtttttgt tcatccgccatattgtgttg aThis corresponds to the amino acid sequence <SEQ ID 822; ORF 229.ng>:

g229.pep 1 MAAVSGGGAV FLIMLPHIAR VQRQPPAFAQ ASGEIGIEAA GEIVSAAAQE 51VLPDKRHGAE RARYRTVLMA ERQAQVLFAE IFVIPIMHAA ADAAVEEMMP 101 ARIDFARHAQAVAQTVCLLR QAVGGFRPAS ARKFNRFFGR SVVYSGLTKI 151 RTRRRAAGST DGTEPVRPVLGRLREPFPLS RGGATRTGFC SSAILC*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 823>:

m229.seq (partial) 1 ..GCTCAAGCGT TGGGAGAAAT CGGCATTGAA GCCGCCGACGAAATTGTATC 51   GGCTGCCGCC TAAGAGGTTT TGCTCGACAA ACGGCACGAT GCCGAACGAG101   CGCGTTACCG AACGGTTTTT ATAGCCGAAC GACAGGCGCA GGCTCTGTTC 151  GCTGAAATCT TTGTTATCCC AATAATGCAC GCCGCCGCCG CTGATGCCGC 201  CGTAGAGGAA ATGATGCCTG CCCGCATTGA TTTCGCGCGA CACGCCTAAG 251  CCCTAGCGCA AACCGTGTGC CTTTTGCGGC AGGCTGTCGG CGGTTTTCGT 301  CCAGCTTCTG CCCGCAAATT CAATCGTTTT TTCGGACGAA GCGTTGTTTA 351  TAGCGGATTA ACAAAAATCA GGACAAGGCA ACGAAGCCGC AGACAGTACA 401  AATAGTACGG AACCGATTCA CTTGGTGCTT CAGCACcTTA GAGAATCGTT 451  CTCTTTTTTG TTCATCCGCT ATATTGTGTT GAThis corresponds to the amino acid sequence <SEQ ID 824; ORF 229>:

m229.pep (partial) 1..AQALGEIGIE AADEIVSAAA XEVLLDKRHD AERARYRTVF IAERQAQALF 51  AEIFVIPIMH AAAADAAVEE MMPARIDFAR HAXALAQTVC LLRQAVGGFR 101  PASARKFNRF FGRSVVYSGL TKIRTRQRSA DSTNSTEPIH LVLQHLRESR 151  SLFCSSAILC *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 229 shows 80.5% identity over a 169 aa overlap with a predicted ORF(ORF 229.ng) from N. gonorrhoeae:

m229/g209                                       10        20        30m229.pep                               AQALGEIGIEAADEIVSAAAXEVLLDKRHDAE                              ||| |||||||| ||||||| ||| |||| || g229  MAAVSGGGAVFLIMLPHIARVQRQPPAFAQASGEIGIEAAGEIVSAAAQEVLPDKRHGAE          10        20        30        40        50        60        40        50        60        70        80        90 m229.pep  RARYRTVFIAERQAQALFAEIFVIPIMHAAAADAAVEEMMPARIDFARHAXALAQTVCLL  |||||||::||||||:||||||||||||||| |||||||||||||||||| |:||||||| g229  RARYRTVLMAERQAQVLFAEIFVIPIMHAAA-DAAVEEMMPARIDFARHAQAVAQTVCLL          70        80        90        100       110       100       110       120       130       140 m229.pep  RQAVGGFRPASARKFNRFFGRSVVYSGLIKIRTRQRSADSINSTEPIHLVLQHLRE----  ||||||||||||||||||||||||||||||||||:|:| ||::|||:: || :||| g229  RQAVGGFRPASARKFNRFFGRSVVYSGLTKIRTRRRAAGSTDGTEPVRPVLGRLREPFPL120       130       140       150       160       170      150       160 m229.pep   -----SRSLFCSSAILCX        :|: ||||||||g229   SRGGATRTGFCSSAILC 180       190The following partial DNA sequence was identified in N. meningitidis<SEQ ID 825>:

a229.seq (partial) 1ATGGCTGTCG TATCGGGCGG CGGTGCGGTC TTCCTGATAA CGCTTCCACA 51TATTGCCCAC GTTCAGCGTC AGCCGCCA.. GTTCGCTCAA GCGTCGGGAG 101AAATCGGCAT TGAAGCCGCC GACGAAATTG TATCGGCTGC CGCCTAAGAG 151GTTTTGCTCG ATAAACGGCA CGATGCCGAA TGAGCGCGTT ACTGAACGGT 201TTTTATAGCC GAGCGACAGG CGCAGGCTCT GTTCGCTGAA ATCTTTGTTA 251TCCTAATAGT GCACGCCGCC GCCGCTGATG TCTCCGTAGA GGAAATGATG 301CCCGCCCGCA TTGATTTCGC GCGACACGCC CAAGCCGTAG CGCAAACCGT 351GTGCCTTTTG CGGCAGGCTG TCGGCGGTTT TCGTCCAGCT TCTGCCTGCA 401AATTCAATCG TTTTTTCGGA CGAAGCGTTG TTTATAGCGG ATTAACAAAA 451ATCAGGACAA GGCGACGAAG CGCAGACAGT ACAGATAGTA CGGAACCGAT 501TCACTTGGTG CTTCAGCACC TTAGAGAATC GTCTCTTTGA GCTAAGGCGA 551GGCAACGCCG TACTGGTTTT TGTTCATCCA CTATAThis corresponds to the amino acid sequence <SEQ ID 826; ORF 229.a>:

a229.pep (partial) 1MAVVSGGGAV FLITLPHIAH VQRQPPXFAQ ASGEIGIEAA DEIVSAAA*E 51VLLDKRHDAE *ARY*TVFIA ERQAQALFAE IFVILIVHAA AADVSVEEMM 101PARIDFARHA QAVAQTVCLL RQAVGGFRPA SACKFNRFFG RSVVYSGLTK 151IRTRRRSADS TDSTEPIHLV LQHLRESSL* AKARQRRTGF CSSTI m229/a22985.6% identity in 167 aa overlap                                    10        20        30 m229.pep                            AQALGEIGIEAADEIVSAAAXEVLLDKRHDAE                            ||| |||||||||||||||||||||||||||| a229MAVVSGGGAVFLITLPHIAHVQRQPPXFAQASGEIGIEAADEIVSAAAXEVLLDKRHDAE        10        20        30        40        50        60      40        50        60        70        80        90 m229.pepRARYRTVFIAERQAQALFAEIFVIPIMHAAAADAAVEEMMPARIDFARHAXALAQTVCLL  |||||||||||||||||||||| |:||||||::||||||||||||||| |:||||||| a229XARYXTVFIAERQAQALFAEIFVILIVHAAAADVSVEEMMPARIDFARHAQAVAQTVCLL        70        80        90       100       110       120     100       110       120       130       140      149 m229.pepRQAVGGFRPASARKFNRFFGRSVVYSGLIKIRTRQRSADSINSTEPIHLVLQHLRES---|||||||||||| |||||||||||||||||||||:||||||:||||||||||||||| a229RQAVGGFRPASACKFNRFFGRSVVYSGLTKIRTRRRSADSTDSTEPIHLVLQHLRESSLX       130       140       150       160       170       180    150       160 m229.pep ------RSLFCSSAILCX       |: ||||:| a229AKARQRRTGFCSSTI        190The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 827>:

g230.seq 1 atgttccatt ccatcgaaaa atacagaaca cccgcccaag tcttattagg 51cctgattgca ttaacttttg tcggcttcgg cgtcagcacg gtttcccatc 101cgggcgccga ctacatcgtc caagtgggcg acgaaaaaat cagcgagcac 151tcaatcaaca acgccatgca gaacgagcag gcggacggcg gcagcccttg 201gcgcgacgcg gtgttccaat ccctgctgca acgcgcctac ctgaaacagg 251gcgcgaagct gatgggcatt tcggtttctt ccgaacaaat caagcagatg 301attgtggacg atcccaattt ccacgacgca aacggcaaat tcagtcacgc 351gcttttgagt caatacctgt cgcaacgcca tatgtctgaa gaccagtttg 401tcgaagaaat ccgcgatcag tttgccttgc agaatttggt aagcctcgtc 451caaaacggcg tattggtcgg cgacgcgcag gcggaacagc tgatcaggct 501gacgcaggtc aaccgcacca tccgttcgca cactttcaac cccgacgagt 551tcatcgccca agtcaaagcg tctgaagccg atttgcagaa attttataat 601gcgaacaaaa aagactatct gctgccgcag gcggtcaaat tggaatatgt 651cgccttgaat ctgaaggatt ttgcagacaa gcagaccgtc agtgaaacgg 701aagtgaaaaa tgcgtttgaa gagcgcgtgg cgcgtttgcc ggcacatgaa 751gccaaacctt ctttcgagca ggaaaaagcc gccgtcgaaa acgaattgaa 801aatgaaaaag gcggttgccg acttcaacaa ggcaaaagaa aagctgggcg 851acgatgcgtt caatcatccc tcctcgcttg ccgaagccgc caaaaacagc 901ggtttgaaag tggaaaccca agaaacttgg ctgagcaggc aggacgcaca 951aatgtccggc atgcccgaaa acctaatcaa tgccgtattc agcgacgacg 1001tattgaagaa aaaacacaat tccgaagtgc tgaccatcaa cagcgaaacc 1051gcgtgggtcg tccgcgccaa agaagtccgc gaagaaaaaa acctactgtt 1101tgaagaagcc aaagatgcgg tgcgtcaggc ctatatccgt accgaagccg 1151ccaaactttt gaaaacaatg taaThis corresponds to the amino acid sequence <SEQ ID 828; ORF 230.ng>:

g230.pep 1 MFHSIEKYRT PAQVLLGLIA LTFVGFGVST VSHPGADYIV QVGDEKISEH 51SINNAMQNEQ ADGGSPWRDA VFQSLLQRAY LKQGAKLMGI SVSSEQIKQM 101IVDDPNFHDA NGKFSHALLS QYLSQRHMSE DQFVEEIRDQ FALQNLVSLV 151QNGVLVGDAQ AEQLIRLTQV NRTIRSHTFN PDEFIAQVKA SEADLQKFYN 201ANKKDYLLPQ AVKLEYVALN LKDFADKQTV SETEVKNAFE ERVARLPAHE 251AKPSFEQEKA AVENELKMKK AVADFNKAKE KLGDDAFNHP SSLAEAAKNS 301GLKVETQETW LSRQDAQMSG MPENLINAVF SDDVLKKKHN SEVLTINSET 351AWVVRAKEVR EEKNLLFEEA KDAVRQAYIR TEAAKLLKTM *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 829>:

m230.seq (partial) 1ATGTTCCATT CCATCGAAAA ATACAGAACG CCCGCCCAAG TCCTTTTGGG 51CCTGATTGCA TTAACCTTCG TCGGCTTCGG GGTCAGCACG GTATCCCATC 101CGGGTGCCGA CTACATCGTC CAAGTGGGCG ACGAAAAAaT CAGCGACCAC 151TCCATCAACA ACGCCATACA GAACGAACAG GCGGACGGCG GCGGCCCTTC 201GCc.GACGCG GTGTTCCAAT CCCTGCTGCA ACGCGCCTAC CTGAAACAGG 251GCGCGAAGCT GATGGGCATT TCGGTTTCTT CCGAACAAAT CAAGCAAATT 301ATCGTGGACG ATCCCAATTT CCACGACGCA AACGGCAAAT TCGACCACGC 351GCTTTTAAAC CGCTACCTTT CCCAACGCCA TATGTCTGAA GACCAGTTTG 401TCGAAGAAAT CCGCGATCAG TTTGCCTTGC AGAATTTGGT AAACCTCGTC 451CAAAACGGCG TATTGGTCGG CGACGCGCAG GCGGAACAGC TGATCAGGCT 501GACACAGGTC AACCGCACCA TCCGTTCGCA CACTTTCAAC CCCGACGAGT 551TCATCGCCCA AGTCAAAGTG TCTGAAGCCG ATTTGCAGAA ATTTTATAAT 601GCGAACAAAA AAGACTATCT GCTGCCGCAG gCGGTCAAAT TGGAATATGT 651CGCCTTGAAT CTGAAGGATT TTGCAGACAA GCAGACCGTC AGTGAAACGg 701AAGTGAAAAA TGCATTTGAA GAGCGCGTGG CGCGTTTGCC GGCAAATGAA 751GCCAAACCTT CTTTCGAGCA GGAAAAAGCC GCCGTCGAAA ACGAATTGAA 801AATGAAAAAG GCGGTTGCCG ACTTCAACAA GGCAAAAGAA AAATTGGGCG 851ACGATGC.GT cAACCATCCT TCyTCGCTTG CCGAAGCCGC CAAAAACAGC 901GGTTTGAAAG TCGAAACCCA AGAAACTTGG CTGAGTAGGC AGGACGCGCA 951AATGTCCGGT ATGCCCGAAA ACCTGATCAA TGCCGTATTC AGCGACGACG 1001TATTGAAGAA AAAACACAAT TCCGAAGTGC TGACCATCAA CAGCGAAACC 1051GCGTGGGTCG TCCGCGCCAA AGAAGTCCGC GAAGAGAAAA CCCTGCCGTT 1101TGCCGAAGCC AAAGACGCGG TACGTCAGGC TTATATCCGT ACCGAAGCCG 1151CCAAACTT.. ...This corresponds to the amino acid sequence <SEQ ID 830; ORF 230>:

m230.pep (partial) 1MFHSIEKYRT PAQVLLGLIA LTFVGFGVST VSHPGADYIV QVGDEKISDH 51SINNAIQNEQ ADGGGPSPDA VFQSLLQRAY LKQGAKLMGI SVSSEQIKQI 101IVDDPNFHDA NGKFDHALLN RYLSQRHMSE DQFVEEIRDQ FALQNLVNLV 151QNGVLVGDAQ AEQLIRLTQV NRTIRSHTFN PDEFIAQVKV SEADLQKFYN 201ANKKDYLLPQ AVKLEYVALN LKDFADKQTV SETEVKNAFE ERVARLPANE 251AKPSFEQEKA AVENELKMKK AVADFNKAKE KLGDDAVNHP SSLAEAAKNS 301GLKVETQETW LSRQDAQMSG MPENLINAVF SDDVLKKKHN SEVLTINSET 351AWVVRAKEVR EEKTLPFAEA KDAVRQAYIR TEAAKL....Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 230 shows 95.9% identity over a 386 aa overlap with a predicted ORF(ORF 230.ng) from N. gonorrhoeae:

m230/g230         10        20        30        40        50        60m230.pep MFHSIEKYRTPAQVLLGLIALTFVGFGVSTVSHPGADYIVQVGDEKISDHSINNAIQNEQ||||||||||||||||||||||||||||||||||||||||||||||||:||||||:|||| g230MFHSIEKYRTPAQVLLGLIALTFVGFGVSTVSHPGADYIVQVGDEKISEHSINNAMQNEQ        10        20        30        40        50        60        70        80        90       100       110       120 m230.pepADGGGPSPDAVFQSLLQRAYLKQGAKLMGISVSSEQIKQIIVDDPNFHDANGKFDHALLN ||||:| |||||||||||||||||||||||||||||||:||||||||||||||:||||: g230ADGGSPWRDAVFQSLLQRAYLKQGAKLMGISVSSEQIKQMIVDDPNFHDANGKFSHALLS        70        80        90       100       110       120       130       140       150       160       170       180 m230.pepRYLSQRHMSEDQFVEEIRDQFALQNLVNLVQNGVLVGDAQAEQLIRLTQVNRTIRSHTFN:||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||| g230QYLSQRHMSEDQFVEEIRDQFALQNLVSLVQNGVLVGDAQAEQLIRLTQVNRTIRSHTFN       130       140       150       160       170       180       190       200       210       220       230       240 m230.pepPDEFIAQVKVSEADLQKFYNANKKDYLLPQAVKLEYVALNLKDFADKQTVSETEVKNAFE|||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||| g230PDEFIAQVKASEADLQKFYNANKKDYLLPQAVKLEYVALNLKDFADKQTVSETEVKNAFE       190       200       210       220       230       240       250       260       270       280       290       300 m230.pepERVARLPANEAKPSFEQEKAAVENELKMKKAVADFNKAKEKLGDDAVNHPSSLAEAAKNS||||||||:||||||||||||||||||||||||||||||||||||| ||||||||||||| g230ERVARLPAHEAKPSFEQEKAAVENELKMKKAVADFNKAKEKLGDDAFNHPSSLAEAAKNS       250       260       270       280       290       300       310       320       330       340       350       360 m230.pepGLKVETQETWLSRQDAQMSGMPENLINAVFSDDVLKKKHNSEVLTINSETAWVVRAKEVR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g230GLKVETQETWLSRQDAQMSGMPENLINAVFSDDVLKKKHNSEVLTINSETAWVVRAKEVR       310       320       330       340       350       360       370       380 m230.pep EEKTLPFAEAKDAVRQAYIRTEAAKL |||:| ||||||||||||||||||| g230 EEKNLLFEEAKDAVRQAYIRTEAAKLLKTM       370       380       390The following partial DNA sequence was identified in N. meningitidis<SEQ ID 831>:

a230.seq (partial) 1ATGTTCCATT CCATCGAAAA ATACAGAACG CCCGCCCAAG TCCTTTTGGG 51CCTGATTGCA TTAACCTTCG TCGGCTTCGG GGTCAGCACG GTATCCCATC 101CGGGTGCCGA CTACATCGTC CAAGTGGGCG ACGAAAAAAT CAGCGACCAC 151TCCATCAACA ACGCCATACA GAACGAACAG GCGGACGGCG GCGGCCCTTC 201GCGCGACGCG GTGTTCCAAT CCCTGCTACA ACGCGCCTAC CTGAAACAGG 251GCGCGAAGCT GATGGGCATT TCGGTTTCTT CCGAACAAAT CAAGCAGATT 301ATCGTGGACG ATCCCAATTT CCACGACGCA AACGGCAAAT TCGACCACGC 351GCTTTTAAAC CGCTACCTTT CCCAACGTCA TATGTCTGAA GACCAGTTTG 401TCGAAGAAAT CCGCGATCAG TTTGCCTTGC AGAATTTGGT AAACCTCGTC 451CAAAACGGCG TATTGGTCGG CGACGCGCAG GCGGAACAGC TGATCAGGCT 501GACGCAGGTC AACCGCACCA TCCGTTCGCA CACTTTCAAC CCCGACGAAT 551TCATCGCCCA AGTCAAAGTG TCTGAAGCCG ATTTGCAGAA GTTTTATAAC 601GCAAACAAAA AAGACTACCT GCTTCCCAAA GCGGTCAAAT TGGAATATGT 651CGCCTTGAAT CTGAAAGACT TTGCAGACAA ACAGACCGTC AGCGAAACAG 701AAGTGAAAAA TGCGTTTGAA GAGCGCGTGG CGCGTTTGCC GGCAAATGAA 751GCCAAACCTT CTTTCGAGCA GGAAAAAGCC GCCGTCGAAA ACGAATTGAA 801AATGAAAAAG GCGGTTGCCG ACTTCAATAA GGCAAAAGAA AAGCTGGGCG 851ATGACGCGTT CAACCATCCT TCCTCGCTTG CCGAAGCCGC CAAAAACAGC 901GGTTTGAAAG TCGAAACCCA AGAAACTTGG CTGAGCAGGC AGGATGCGCA 951AATGTCCGGT ATGCCCGAAA ACCTGATCAA TGCCGTATTC AGCGACGACG 1001TATTGAAGAA AAAACACAAT TCCGAAGTGC TGACCATCAA CAGCGAAACC 1051GCGTGGGTCG TCCGCGCCAA AGAAGTCCGC GAAGAGAAAA CCCTGCCGTT 1101TGCCGAAGCC AAAGACGCGG TACGTCAGGC TTATATCCGT ACCGAAGCCG 1151 CCAAACTTThis corresponds to the amino acid sequence <SEQ ID 832; ORF 230.a>:

a230.pep (partial) 1MFHSIEKYRT PAQVLLGLIA LTFVGFGVST VSHPGADYIV QVGDEKISDH 51SINNAIQNEQ ADGGGPSRDA VFQSLLQRAY LKQGAKLMGI SVSSEQIKQI 101IVDDPNFHDA NGKFDHALLN RYLSQRHMSE DQFVEEIRDQ FALQNLVNLV 151QNGVLVGDAQ AEQLIRLTQV NRTIRSHTFN PDEFIAQVKV SEADLQKFYN 201ANKKDYLLPK AVKLEYVALN LKDFADKQTV SETEVKNAFE ERVARLPANE 251AKPSFEQEKA AVENELKMKK AVADFNKAKE KLGDDAFNHP SSLAEAAKNS 301GLKVETQETW LSRQDAQMSG MPENLINAVF SDDVLKKKHN SEVLTINSET 351AWVVRAKEVR EEKTLPFAEA KDAVRQAYIR TEAAKL m230/a23099.2% identity in 386 aa overlap        10        20        30        40        50        60 m230.pepMFHSIEKYRTPAQVLLGLIALTFVGFGVSTVSHPGADYIVQVGDEKISDHSINNAIQNEQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a230MFHSIEKYRTPAQVLLGLIALTFVGFGVSTVSHPGADYIVQVGDEKISDHSINNAIQNEQ        10        20        30        40        50        60        70        80        90       100       110       120 m230.pepADGGGPSPDAVFQSLLQRAYLKQGAKLMGISVSSEQIKQIIVDDPNFHDANGKFDHALLN ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a230ADGGGPSRDAVFQSLLQRAYLKQGAKLMGISVSSEQIKQIIVDDPNFHDANGKFDHALLN        70        80        90       100       110       120       130       140       150       160       170       180 m230.pepRYLSQRHMSEDQFVEEIRDQFALQNLVNLVQNGVLVGDAQAEQLIRLTQVNRTIRSHTFN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a230RYLSQRHMSEDQFVEEIRDQFALQNLVNLVQNGVLVGDAQAEQLIRLTQVNRTIRSHTFN       130       140       150       160       170       180       190       200       210       220       230       240 m230.pepPDEFIAQVKVSEADLQKFYNANKKDYLLPQAVKLEYVALNLKDFADKQTVSETEVKNAFE|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| a230PDEFIAQVKVSEADLQKFYNANKKDYLLPKAVKLEYVALNLKDFADKQTVSETEVKNAFE       190       200       210       220       230       240       250       260       270       280       290       300 m230.pepERVARLPANEAKPSFEQEKAAVENELKMKKAVADFNKAKEKLGDDAVNHPSSLAEAAKNS|||||||||||||||||||||||||||||||||||||||||||||| ||||||||||||| a230ERVARLPANEAKPSFEQEKAAVENELKMKKAVADFNKAKEKLGDDAFNHPSSLAEAAKNS       250       260       270       280       290       300       310       320       330       340       350       360 m230.pepGLKVETQETWLSRQDAQMSGMPENLINAVFSDDVLKKKHNSEVLTINSETAWVVRAKEVR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a230GLKVETQETWLSRQDAQMSGMPENLINAVFSDDVLKKKHNSEVLTINSETAWVVRAKEVR       310       320       330       340       350       360       370       380 m230.pep EEKTLPFAEAKDAVRQAYIRTEAAKL|||||||||||||||||||||||||| a230 EEKTLPFAEAKDAVRQAYIRTEAAKL       370       380The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 833>:

g230-1.seq 1 ATGTTCCATT CCATCGAAAA ATACAGAACA CCCGCCCAAG TCTTATTAGG 51CCTGATTGCA TTAACTTTTG TCGGCTTCGG CGTCAGCACG GTTTCCCATC 101CGGGCGCCGA CTACATCGTC CAAGTGGGCG ACGAAAAAAT CAGCGAGCAC 151TCAATCAACA ACGCCATGCA GAACGAGCAG GCGGACGGCG GCAGCCCTTG 201GCGCGACGCG GTGTTCCAAT CCCTGCTGCA ACGCGCCTAC CTGAAACAGG 251GCGCGAAGCT GATGGGCATT TCGGTTTCTT CCGAACAAAT CAAGCAGATG 301ATTGTGGACG ATCCCAATTT CCACGACGCA AACGGCAAAT TCAGTCACGC 351GCTTTTGAGT CAATACCTGT CGCAACGCCA TATGTCTGAA GACCAGTTTG 401TCGAAGAAAT CCGCGATCAG TTTGCCTTGC AGAATTTGGT AAGCCTCGTC 451CAAAACGGCG TATTGGTCGG CGACGCGCAG GCGGAACAGC TGATCAGGCT 501GACGCAGGTC AACCGCACCA TCCGTTCGCA CACTTTCAAC CCCGACGAGT 551TCATCGCCCA AGTCAAAGCG TCTGAAGCCG ATTTGCAGAA ATTTTATAAT 601GCGAACAAAA AAGACTATCT GCTGCCGCAG GCGGTCAAAT TGGAATATGT 651CGCCTTGAAT CTGAAGGATT TTGCAGACAA GCAGACCGTC AGTGAAACGG 701AAGTGAAAAA TGCGTTTGAA GAGCGCGTGG CGCGTTTGCC GGCACATGAA 751GCCAAACCTT CTTTCGAGCA GGAAAAAGCC GCCGTCGAAA ACGAATTGAA 801AATGAAAAAG GCGGTTGCCG ACTTCAACAA GGCAAAAGAA AAGCTGGGCG 851ACGATGCGTT CAATCATCCC TCCTCGCTTG CCGAAGCCGC CAAAAACAGC 901GGTTTGAAAG TGGAAACCCA AGAAACTTGG CTGAGCAGGC AGGACGCACA 951AATGTCCGGC ATGCCCGAAA ACCTAATCAA TGCCGTATTC AGCGACGACG 1001TATTGAAGAA AAAACACAAT TCCGAAGTGC TGACCATCAA CAGCGAAACC 1051GCGTGGGTCG TCCGCGCCAA AGAAGTCCGC GAAGAAAAAA ACCTACTGTT 1101TGAAGAAGCC AAAGATGCGG TGCGTCAGGC CTATATCCGT ACCGAAGCCG 1151CCAAACTTGC CGAAAACAAG GCAAAAGAAG TGCTTACCCA ACTGAACGGC 1201GGCAAGGCAG TTGACGTGAA ATGGTCGGAA GTGTCCGTTT TGGGCGCGCA 1251GCAGGCAAGG CAGTCCATGC CGCCCGAGGC TTATGCGGAA CTGCTGAAAG 1301CAAAACCGGC AAACGGCAAA CCCGCCTATG TCAGACTGAC CGGTCTGCCG 1351GCACCCGTGA TTGTCGAGGC GCAGGCAGTC ACGCCTCCGG AGGATATTGC 1401CGCACAGCTT CCTCCTGCGA AACAGGCTTT GGCGCAACAG CAGTCTGCCA 1451ATACTTTCGA CCTGCTGATC CGCTATTTCA ACGGAAAAAT CAAACAGACT 1501AAAGGAGCAC AATCGGTTGA CAACGGCGAT GGTCAGTAAThis corresponds to the amino acid sequence <SEQ ID 834; ORF 230-1.ng>:

g230-1.pep 1 MFHSIEKYRT PAQVLLGLIA LTFVGFGVST VSHPGADYIV QVGDEKISEH 51SINNAMQNEQ ADGGSPWRDA VFQSLLQRAY LKQGAKLMGI SVSSEQIKQM 101IVDDPNFHDA NGKFSHALLS QYLSQRHMSE DQFVEEIRDQ FALQNLVSLV 151QNGVLVGDAQ AEQLIRLTQV NRTIRSHTFN PDEFIAQVKA SEADLQKFYN 201ANKKDYLLPQ AVKLEYVALN LKDFADKQTV SETEVKNAFE ERVARLPAHE 251AKPSFEQEKA AVENELKMKK AVADFNKAKE KLGDDAFNHP SSLAEAAKNS 301GLKVETQETW LSRQDAQMSG MPENLINAVF SDDVLKKKHN SEVLTINSET 351AWVVRAKEVR EEKNLLFEEA KDAVRQAYIR TEAAKLAENK AKEVLTQLNG 401GKAVDVKWSE VSVLGAQQAR QSMPPEAYAE LLKAKPANGK PAYVRLTGLP 451APVIVEAQAV TPPEDIAAQL PPAKQALAQQ QSANTFDLLI RYFNGKIKQT 501KGAQSVDNGD GQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 835>:

m230-1.seq 1 ATGTTCCATT CCATCGAAAA ATACAGAACG CCCGCCCAAG TCCTTTTGGG 51CCTGATTGCA TTAACCTTCG TCGGCTTCGG GGTCAGCACG GTATCCCATC 101CGGGTGCCGA CTACATCGTC CAAGTGGGCG ACGAAAAAAT CAGCGACCAC 151TCCATCAACA ACGCCATACA GAACGAACAG GCGGACGGCG GCGGCCCTTC 201GCGCGACGCG GTGTTCCAAT CCCTGCTGCA ACGCGCCTAC CTGAAACAGG 251GCGCGAAGCT GATGGGCATT TCGGTTTCTT CCGAACAAAT CAAGCAAATT 301ATCGTGGACG ATCCCAATTT CCACGACGCA AACGGCAAAT TCGACCACGC 351GCTTTTAAAC CGCTACCTTT CCCAACGCCA TATGTCTGAA GACCAGTTTG 401TCGAAGAAAT CCGCGATCAG TTTGCCTTGC AGAATTTGGT AAACCTCGTC 451CAAAACGGCG TATTGGTCGG CGACGCGCAG GCGGAACAGC TGATCAGGCT 501GACACAGGTC AACCGCACCA TCCGTTCGCA CACTTTCAAC CCCGACGAGT 551TCATCGCCCA AGTCAAAGTG TCTGAAGCCG ATTTGCAGAA ATTTTATAAT 601GCGAACAAAA AAGACTATCT GCTGCCGCAG GCGGTCAAAT TGGAATATGT 651CGCCTTGAAT CTGAAGGATT TTGCAGACAA GCAGACCGTC AGTGAAACGG 701AAGTGAAAAA TGCATTTGAA GAGCGCGTGG CGCGTTTGCC GGCAAATGAA 751GCCAAACCTT CTTTCGAGCA GGAAAAAGCC GCCGTCGAAA ACGAATTGAA 801AATGAAAAAG GCGGTTGCCG ACTTCAACAA GGCAAAAGAA AAATTGGGCG 851ACGATGCGTT CAACCATCCT TCCTCGCTTG CCGAAGCCGC CAAAAACAGC 901GGTTTGAAAG TCGAAACCCA AGAAACTTGG CTGAGTAGGC AGGACGCGCA 951AATGTCCGGT ATGCCCGAAA ACCTGATCAA TGCCGTATTC AGCGACGACG 1001TATTGAAGAA AAAACACAAT TCCGAAGTGC TGACCATCAA CAGCGAAACC 1051GCGTGGGTCG TCCGCGCCAA AGAAGTCCGC GAAGAGAAAA CCCTGCCGTT 1101TGCCGAAGCC AAAGACGCGG TACGTCAGGC TTATATCCGT ACCGAAGCCG 1151CCAAACTTGC CGAAAACAAG GCAAAAGACG TGCTTACCCA ACTGAACGGC 1201GGCAAGGCTG TTGACGTGAA ATGGTCGGAA GTGTCCGTTT TGGGCGCACA 1251GCAGGCAAGG CAGTCCATGC CGCCCGAGGC TTATGCGGAA CTGCTGAAAG 1301CAAAACCGGC AAACGGCAAA CCCGCCTACG TCAGGCTGAT CGGTCTGCCG 1351GCACCCGTGA TTGTCGAAGT ACAGGCTGTA ACCCCGCCGG ATGATATCGC 1401CGCACAGCTT CCGCTTGCAA AACAGGCTTT GGCGCAACAG CAGTCTGCCA 1451ATACTTTCGA CTTGTTGATA CGTTATTTCA ACGGCAAAAT CAAACAGACC 1501AAAGGAGCGC AATCGGTCGA CAACGGCGAC GGTCAGTAAThis corresponds to the amino acid sequence <SEQ ID 836; ORF 230-1>:

m230-1.pep 1 MFHSIEKYRT PAQVLLGLIA LTFVGFGVST VSHPGADYIV QVGDEKISDH 51SINNAIQNEQ ADGGGPSRDA VFQSLLQRAY LKQGAKLMGI SVSSEQIKQI 101IVDDPNFHDA NGKFDHALLN RYLSQRHMSE DQFVEEIRDQ FALQNLVNLV 151QNGVLVGDAQ AEQLIRLTQV NRTIRSHTFN PDEFIAQVKV SEADLQKFYN 201ANKKDYLLPQ AVKLEYVALN LKDFADKQTV SETEVKNAFE ERVARLPANE 251AKPSFEQEKA AVENELKMKK AVADFNKAKE KLGDDAFNHP SSLAEAAKNS 301GLKVETQETW LSRQDAQMSG MPENLINAVF SDDVLKKKHN SEVLTINSET 351AWVVRAKEVR EEKTLPFAEA KDAVRQAYIR TEAAKLAENK AKDVLTQLNG 401GKAVDVKWSE VSVLGAQQAR QSMPPEAYAE LLKAKPANGK PAYVRLIGLP 451APVIVEVQAV TPPDDIAAQL PLAKQALAQQ QSANTFDLLI RYFNGKIKQT 501KGAQSVDNGD GQ* m230-1/g230-1 96.3% identity in 512 aa overlap        10        20        30        40        50        60 m230-1.pepMFHSIEKYRTPAQVLLGLIALTFVGFGVSTVSHPGADYIVQVGDEKISDHSINNAIQNEQ||||||||||||||||||||||||||||||||||||||||||||||||:||||||:|||| g230-1MFHSIEKYRTPAQVLLGLIALTFVGFGVSTVSHPGADYIVQVGDEKISEHSINNAMQNEQ        10        20        30        40        50        60        70        80        90       100       110       120 m230-1.pepADGGGPSRDAVFQSLLQRAYLKQGAKLMGISVSSEQIKQIIVDDPNFHDANGKFDHALLN ||||:|||||||||||||||||||||||||||||||||:||||||||||||||:||||: g230-1ADGGSPWRDAVFQSLLQRAYLKQGAKLMGISVSSEQIKQMIVDDPNFHDANGKFSHALLS        70        80        90       100       110       120       130       140       150       160       170       180 m230-1.pepRYLSQRHMSEDQFVEEIRDQFALQNLVNLVQNGVLVGDAQAEQLIRLTQVNRTIRSHTFN:||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||| g230-1QYLSQRHMSEDQFVEEIRDQFALQNLVSLVQNGVLVGDAQAEQLIRLTQVNRTIRSHTFN       130       140       150       160       170       180       190       200       210       220       230       240 m230-1.pepPDEFIAQVKVSEADLQKFYNANKKDYLLPQAVKLEYVALNLKDFADKQTVSETEVKNAFE|||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||| g230-1PDEFIAQVKASEADLQKFYNANKKDYLLPQAVKLEYVALNLKDFADKQTVSETEVKNAFE       190       200       210       220       230       240       250       260       270       280       290       300 m230-1.pepERVARLPANEAKPSFEQEKAAVENELKMKKAVADFNKAKEKLGDDAFNHPSSLAEAAKNS||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||| g230-1ERVARLPAHEAKPSFEQEKAAVENELKMKKAVADFNKAKEKLGDDAFNHPSSLAEAAKNS       250       260       270       280       290       300       310       320       330       340       350       360 m230-1.pepGLKVETQETWLSRQDAQMSGMPENLINAVFSDDVLKKKHNSEVLTINSETAWVVRAKEVR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g230-1GLKVETQETWLSRQDAQMSGMPENLINAVFSDDVLKKKHNSEVLTINSETAWVVRAKEVR       310       320       330       340       350       360       370       380       390       400       410       420 m230-1.pepEEKTLPFAEAKDAVRQAYIRTEAAKLAENKAKDVLTQLNGGKAVDVKWSEVSVLGAQQAR |||:| |||||||||||||||||||||||||:||||||||||||||||||||||||||| g230-1EEKNLLFEEAKDAVRQAYIRTEAAKLAENKAKEVLTQLNGGKAVDVKWSEVSVLGAQQAR       370       380       390       400       410       420       430       440       450       460       470       480 m230-1.pepQSMPPEAYAELLKAKPANGKPAYVRLIGLPAPVIVEVQAVTPPDDIAAQLPLAKQALAQQ|||||||||||||||||||||||||| |||||||||:||||||:||||||| |||||||| g230-1QSMPPEAYAELLKAKPANGKPAYVRLTGLPAPVIVEAQAVTPPEDIAAQLPPAKQALAQQ       430       440       450       460       470       480       490       500       510 m230-1.pepQSANTFDLLIRYFNGKIKQTKGAQSVDNGDGQX |||||||||||||||||||||||||||||||||g230-1 QSANTFDLLIRYFNGKIKQTKGAQSVDNGDGQX        490       500       510The following partial DNA sequence was identified in N. meningitidis<SEQ ID 837>:

a230-1.seq 1 ATGTTCCATT CCATCGAAAA ATACAGAACG CCCGCCCAAG TCCTTTTGGG 51CCTGATTGCA TTAACCTTCG TCGGCTTCGG GGTCAGCACG GTATCCCATC 101 CGGGTGCCGACTACATCGTC CAAGTGGGCG ACGAAAAAAT CAGCGACCAC 151 TCCATCAACA ACGCCATACAGAACGAACAG GCGGACGGCG GCGGCCCTTC 201 GCGCGACGCG GTGTTCCAAT CCCTGCTACAACGCGCCTAC CTGAAACAGG 251 GCGCGAAGCT GATGGGCATT TCGGTTTCTT CCGAACAAATCAAGCAGATT 301 ATCGTGGACG ATCCCAATTT CCACGACGCA AACGGCAAAT TCGACCACGC351 GCTTTTAAAC CGCTACCTTT CCCAACGTCA TATGTCTGAA GACCAGTTTG 401TCGAAGAAAT CCGCGATCAG TTTGCCTTGC AGAATTTGGT AAACCTCGTC 451 CAAAACGGCGTATTGGTCGG CGACGCGCAG GCGGAACAGC TGATCAGGCT 501 GACGCAGGTC AACCGCACCATCCGTTCGCA CACTTTCAAC CCCGACGAAT 551 TCATCGCCCA AGTCAAAGTG TCTGAAGCCGATTTGCAGAA GTTTTATAAC 601 GCAAACAAAA AAGACTACCT GCTTCCCAAA GCGGTCAAATTGGAATATGT 651 CGCCTTGAAT CTGAAAGACT TTGCAGACAA ACAGACCGTC AGCGAAACAG701 AAGTGAAAAA TGCGTTTGAA GAGCGCGTGG CGCGTTTGCC GGCAAATGAA 751GCCAAACCTT CTTTCGAGCA GGAAAAAGCC GCCGTCGAAA ACGAATTGAA 801 AATGAAAAAGGCGGTTGCCG ACTTCAATAA GGCAAAAGAA AAGCTGGGCG 851 ATGACGCGTT CAACCATCCTTCCTCGCTTG CCGAAGCCGC CAAAAACAGC 901 GGTTTGAAAG TCGAAACCCA AGAAACTTGGCTGAGCAGGC AGGATGCGCA 951 AATGTCCGGT ATGCCCGAAA ACCTGATCAA TGCCGTATTCAGCGACGACG 1001 TATTGAAGAA AAAACACAAT TCCGAAGTGC TGACCATCAA CAGCGAAACC1051 GCGTGGGTCG TCCGCGCCAA AGAAGTCCGC GAAGAGAAAA CCCTGCCGTT 1101TGCCGAAGCC AAAGACGCGG TACGTCAGGC TTATATCCGT ACCGAAGCCG 1151 CCAAACTTGCCGAAAACAAG GCAAAAGACG TGCTTACCCA ACTGAACGGC 1201 GGCAAGGCTG TTGACGTGAAATGGTCGGAA GTGTCCGTTT TGGGCGCACA 1251 GCAGGCAAGG CAGTCCATGC CGCCCGAGGCTTATGCGGAA CTGCTGAAAG 1301 CAAAACCGGC AAACGGCAAA CCCGCCTACG TCAGGCTGATCGGTCTGCCG 1351 GCACCCGTGA TTGTCGAAGT ACAGGCTGTA ACCCCGCCGG ATGATATCGC1401 CGCACAGCTT CCGCTTGCAA AACAGGCTTT GGCGCAACAG CAGTCTGCCA 1451ATACTTTCGA CTTGTTGATA CGTTATTTCA ACGGCAAAAT CAAACAGACC 1501 AAAGGAGCGCAATCGGTCGA CAACGGCGAC GGTCAGTAAThis corresponds to the amino acid sequence <SEQ ID 838; ORF 230-1.a>:

a230-1.pep 1 MFHSIEKYRT PAQVLLGLIA LTFVGFGVST VSHPGADYIV QVGDEKISDH 51SINNAIQNEQ ADGGGPSRDA VFQSLLQRAY LKQGAKLMGI SVSSEQIKQI 101 IVDDPNFHDANGKFDHALLN RYLSQRHMSE DQFVEEIRDQ FALQNLVNLV 151 QNGVLVGDAQ AEQLIRLTQVNRTIRSHTFN PDEFIAQVKV SEADLQKFYN 201 ANKKDYLLPK AVKLEYVALN LKDFADKQTVSETEVKNAFE ERVARLPANE 251 AKPSFEQEKA AVENELKMKK AVADFNKAKE KLGDDAFNHPSSLAEAAKNS 301 GLKVETQETW LSRQDAQMSG MPENLINAVF SDDVLKKKHN SEVLTINSET351 AWVVRAKEVR EEKTLPFAEA KDAVRQAYIR TEAAKLAENK AKDVLTQLNG 401GKAVDVKWSE VSVLGAQQAR QSMPPEAYAE LLKAKPANGK PAYVRLIGLP 451 APVIVEVQAVTPPDDIAAQL PLAKQALAQQ QSANTFDLLI RYFNGKIKQT 501 KGAQSVDNGD GQ*a230-1/m230-1 99.8% identity in 512 aa overlap        10        20        30        40        50        60 a230-1.pepMFHSIEKYRTPAQVLLGLIALTFVGFGVSTVSHPGADYIVQVGDEKISDHSINNAIQNEQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m230-1MFHSIEKYRTPAQVLLGLIALTFVGFGVSTVSHPGADYIVQVGDEKISDHSINNAIQNEQ        10        20        30        40        50        60        70        80        90       100       110       120 a230-1.pepADGGGPSRDAVFQSLLQRAYLKQGAKLMGISVSSEQIKQIIVDDPNFHDANGKFDHALLN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m230-1ADGGGPSRDAVFQSLLQRAYLKQGAKLMGISVSSEQIKQIIVDDPNFHDANGKFDHALLN        70        80        90       100       110       120       130       140       150       160       170       180 a230-1.pepRYLSQRHMSEDQFVEEIRDQFALQNLVNLVQNGVLVGDAQAEQLIRLTQVNRTIRSHTFN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m230-1RYLSQRHMSEDQFVEEIRDQFALQNLVNLVQNGVLVGDAQAEQLIRLTQVNRTIRSHTFN       130       140       150       160       170       180       190       200       210       220       230       240 a230-1.pepPDEFIAQVKVSEADLQKFYNANKKDYLLPKAVKLEYVALNLKDFADKQTVSETEVKNAFE|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| m230-1PDEFIAQVKVSEADLQKFYNANKKDYLLPQAVKLEYVALNLKDFADKQTVSETEVKNAFE       190       200       210       220       230       240       250       260       270       280       290       300 a230-1.pepERVARLPANEAKPSFEQEKAAVENELKMKKAVADFNKAKEKLGDDAFNHPSSLAEAAKNS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m230-1ERVARLPANEAKPSFEQEKAAVENELKMKKAVADFNKAKEKLGDDAFNHPSSLAEAAKNS       250       260       270       280       290       300       310       320       330       340       350       360 a230-1.pepGLKVETQETWLSRQDAQMSGMPENLINAVFSDDVLKKKHNSEVLTINSETAWVVRAKEVR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m230-1GLKVETQETWLSRQDAQMSGMPENLINAVFSDDVLKKKHNSEVLTINSETAWVVRAKEVR       310       320       330       340       350       360       370       380       390       400       410       420 a230-1.pepEEKTLPFAEAKDAVRQAYIRTEAAKLAENKAKDVLTQLNGGKAVDVKWSEVSVLGAQQAR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m230-1EEKTLPFAEAKDAVRQAYIRTEAAKLAENKAKDVLTQLNGGKAVDVKWSEVSVLGAQQAR       370       380       390       400       410       420       430       440       450       460       470       480 a230-1.pepQSMPPEAYAELLKAKPANGKPAYVRLIGLPAPVIVEVQAVTPPDDIAAQLPLAKQALAQQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m230-1QSMPPEAYAELLKAKPANGKPAYVRLIGLPAPVIVEVQAVTPPDDIAAQLPLAKQALAQQ       430       440       450       460       470       480       490       500       510 a230-1.pepQSANTFDLLIRYFNGKIKQTKGAQSVDNGDGQX |||||||||||||||||||||||||||||||||m230-1 QSANTFDLLIRYFNGKIKQTKGAQSVDNGDGQX        490       500       510The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 839>:

g231.seq 1 atgtcaaaac gaaaatccat aaaccgtccg tatcaaaaac cggcggaact 51gccgccgttg caaaataatc cgccatttta ccgtaaaaac cgccgcctga 101 acttttttatcgcggcagac ggcggttgcg cgtctccgca aaaatgcagg 151 gcgcgcggtt ttcagacggcatttgccgtt caaggccgtg cggtgtcttt 201 accaaatgcc caaccattcg cccacggaatccatccaatc cttattgccc 251 ccgccgctcc tgcctgcccg gcggtacgcc cacggcgcttgcggattttt 301 agctttccac aatcctttgc gttccctttc cgcctgaatt tgagcgtcgg351 catagtcggc aaaatccgcc ttatcctgct gttctttagc ataactttta 401taatgccacg ccgccccgtc ctgcacctgc atcaggttca aatcggtttt 451 gccggcggatacctgcgcca cttcgcgctg atagcggtcg gtttcaaaca 501 cacgtacact gactttcctaccctccgccg ccgcgcgcag gttgtcgcgc 551 gaacgtgtac cgtaagcctg tttcatctccggtgcgtcga tatacgccat 601 ccgaatttta tgtttcgcgc cgtcgccgtc gatgacgtgaagggtatcgc 651 cgtcatagac tttggacacc gtgcctgtgt agctgtggcc ggatttcgcc701 gatgcccgtc ggcgaacggg cgcgtcgaaa cccacgtccc ctgcagtgcc 751gagtacgtcg agtacggcaa ccgccgtccg caccgcctca ctgtcatatc 801 ccgtataacccaacgcgccc aaaagcgaca gggcgacggg aagccatttc 851 atgatttttt taatctgcatatttttcaaa tgccgatgcc gtctgaacat 901 ctctgaThis corresponds to the amino acid sequence <SEQ ID 840; ORF 231.ng>:

g231.pep 1 MSKRKSINRP YQKPAELPPL QNNPPFYRKN RRLNFFIAAD GGCASPQKCR 51ARGFQTAFAV QGRAVSLPNA QPFAHGIHPI LIAPAAPACP AVRPRRLRIF 101 SFPQSFAFPFRLNLSVGIVG KIRLILLFFS ITFIMPRRPV LHLHQVQIGF 151 AGGYLRHFAL IAVGFKHTYTDFPTLRRRAQ VVARTCTVSL FHLRCVDIRH 201 PNFMFRAVAV DDVKGIAVID FGHRACVAVAGFRRCPSANG RVETHVPCSA 251 EYVEYGNRRP HRLTVISRIT QRAQKRQGDG KPFHDFFNLHIFQMPMPSEH 301 L*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 841>:

m231.seq (partial) 1 ATGTCAAAAC GAAAATCCAT AAACCGTCCG TATCAAAAACCGGCGGAACT 51 GCCGCCGTTG CAAAATAATC CGCCATTTTA CCGTAAAAAC CGCCGCCTGA 101ACTTTTTTAT CGCGGCAGAC GGCGGTTGCG CGTCTCCGCA AAAATGCAGG 151 GCGCGCGGTTTTCAGACGGC ATTTGCCGTT CAAAGCCGTG CGGTGTCTTT 201 ACCAAATGCC CAACCATTCGGC....This corresponds to the amino acid sequence <SEQ ID 842; ORF 231>:

m231.pep (partial) 1 MSKRKSINRP YQKPAELPPL QNNPPFYRKN RRLNFFIAADGGCASPQKCR 51 ARGFQTAFAV QSRAVSLPNA QPFG.....Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 231 shows 98.6% identity over a 73 aa overlap with a predicted ORF(ORF 231.ng) from N. gonorrhoeae:

m231/g231         10        20        30        40        50        60m231.pep MSKRKSINRPYQKPAELPPLQNNPPFYRKNRRLNFFIAADGGCASPQKCRARGFQTAFAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g231MSKRKSINRPYQKPAELPPLQNNPPFYRKNRRLNFFIAADGGCASPQKCRARGFQTAFAV        10        20        30        40        50        60         70m231.pep QSRAVSLPNAQPFG |:|||||||||||: g231QGRAVSLPNAQPFAHGIHPILIAPAAPACPAVRPRRLRIFSFPQSFAFPFRLNLSVGIVG        70        80        90       100       110       120The following partial DNA sequence was identified in N. meningitidis<SEQ ID 843>:

a231.seq (partial) 1 ATGTCAAAAC GAAAATCCAT AAACCGTCCG TATCAAAAACCGGCGGAACT 51 GCCGCCGTTG CAAAATAATC CGCCATTTTA CCGTAAAAAC CGCCGCCTGA 101ACTTTTTTAT CGNGGCAGAC GGCGGTTGCG CGTCTCCGCA AAAATGCAGG 151 GCGCGCGGTTTTCAGACGGC ATTTGCCGTT CAAAGCCGTG CGGTGTCTTT 201 ACCAAATGCC CAACCATTCGCCCACGGCAT CCATCCAATC CTTATTGCCC 251 CCGCCGCTCC TGCCTGCCCG GCGGTACGCCCACGGCGCTT GCGGATTTTT 301 AGCTTTCCAC AATCCTTTGC GTTCCCTTTC CGCCTGAATTTGAGCGTCGG 351 CATAATCGGC AAAATCCGCC TTATCCTGCT GTTCTTTAGC ATAACTTTTA401 TAATGCCACG CCGCCCCGTC CTGCACCTGC ATCAGGTTCA AATCGGTTTT 451GCCGACAGAA ACCTGCGCCA CTTCGCGCTG GTAGCGGTCG GTGTCGAACA 501 CGCGGACGCTGACTTTCCTG CCTTCCGCCG CCGCGCGCAG GTTGTCGCGC 551 GAACGCGTGC CGTAAGCCTGTTTCATCTCC GGCGCGTCGA TATACGCCAT 601 CCGGATTTTG TGTTTCGCGC CGTCGCCGTCGATAACGTGA AGGGTGTCGC 651 CGTCATAGAC TTTGGACACC GTGCCTGTGT AGCGGTGGCCGGATTTCGCC 701 GATGCTCGGC GGCGGGCGGG CGCGTCGGAA CCCGCGTCCC CTGCCGCGCC751 GAGTACGTCG AGTACGGCAA CCGCCGTCCG CACCGCCTCG CTGCCGTACC 801CCGTATAACC CAACGCACCC AAAAGCGACA AGGCGACGGG AAGCCATTTC 851 ATGATTTTTTTAATCTGCAT ATTTTTCAAA TGCCGATGCC GTCTGAACAT 901 ATCThis corresponds to the amino acid sequence <SEQ ID 844; ORF 217.a>:

a231.pep (partial) 1 MSKRKSINRP YQKPAELPPL QNNPPFYRKN RRLNFFIXADGGCASPQKCR 51 ARGFQTAFAV QSRAVSLPNA QPFAHGIHPI LIAPAAPACP AVRPRRLRIF 101SFPQSFAFPF RLNLSVGIIG KIRLILLFFS ITFIMPRRPV LHLHQVQIGF 151 ADRNLRHFALVAVGVEHADA DFPAFRRRAQ VVARTRAVSL FHLRRVDIRH 201 PDFVFRAVAV DNVKGVAVIDFGHRACVAVA GFRRCSAAGG RVGTRVPCRA 251 EYVEYGNRRP HRLAAVPRIT QRTQKRQGDGKPFHDFFNLH IFQMPMPSEH 301 I m231/a231 98.6% identity in 73 aa overlap        10        20        30        40        50        60 m231.pepMSKRKSINRPYQKPAELPPLQNNPPFYRKNRRLNFFIAADGGCASPQKCRARGFQTAFAV||||||||||||||||||||||||||||||||||||| |||||||||||||||||||||| a231MSKRKSINRPYQKPAELPPLQNNPPFYRKNRRLNFFIXADGGCASPQKCRARGFQTAFAV        10        20        30        40        50        60         70m231.pep QSRAVSLPNAQPFG |||||||||||||: a231QSRAVSLPNAQPFAHGIHPILIAPAAPACPAVRPRRLRIFSFPQSFAFPFRLNLSVGIIG        70        80        90       100       110       120The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 845>:

g231-1.seq 1 ATGTCAAAAC GAAAATCCAT AAACCGTCCG TATCAAAAAC CGGCGGAACT 51GCCGCCGTTG CAAAATAATC CGCCATTTTA CCGTAAAAAC CGCCGcCTGA 101 ACTTTTTTATCGCGGCAGAC GGCGGTTGCG CGTCTCCGCA AAAATGCAGG 151 GCGCGCGGTT TTCAGACGGCATTTGCCGTT CAAGGCCGTG CGGTGTCTTT 201 ACCAAATGCC CAACCATTCG CCCACGGAATCCATCCAATC CTTATTGCCC 251 CCGCCGCTCC TGCCTGCCCG GCGGTACGCC CACGGCGCTTGCGGATTTTT 301 AGCTTTCCAC AATCCTTTGC GTTCCCTTTC CGCCTGAATT TGAGCGTCGG351 CATAGTCGGC AAAATCCGCC TTATCCTGCT GTTCTTTAGC ATAACTTTTA 401TAATGCCACG CCGCCCCGTC CTGCACCTGC ATCAGGTTCA AATCGGTTTT 451 GCCGGCGGATACCTGCGCCA CTTCGCGCTG ATAGCGGTCG GTTTCAAACa 501 CaCgTaCaat gagtttcgtAccctccGCCG ccgcgcgCAG GTTGtcgcGC 551 GAACgTGTAC CGTAagcgtg TTtcatctccGGTGCgtcGA TATACGCCaT 601 cCgAATTTta tGTttcgcgc cgtcgcCgtc gATGACGTGAAGGGtatcGC 651 CgtcATAGAC TTTGGACACC Gtgcctgcgt AGctGTGGCC GGATttcgcThis corresponds to the amino acid sequence <SEQ ID 846; ORF 231-1.ng>:

g231-1.pep 1 MSKRKSINRP YQKPAELPPL QNNPPFYRKN RRLNFFIAAD GGCASPQKCR 51ARGFQTAFAV QGRAVSLPNA QPFAHGIHPI LIAPAAPACP AVRPRRLRIF 101 SFPQSFAFPFRLNLSVGIVG KIRLILLFFS ITFIMPRRPV LHLHQVQIGF 151 AGGYLRHFAL IAVGFKHTYNEFRTLRRRAQ VVARTCTVSV FHLRCVDIRH 201 PNFMFRAVAV DDVKGIAVID FGHRACVAVAGFRThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 847>:

m231-1.seq 1 ATGTCAAAAC GAAAATCCAT AAACCGTCCG TATCAAAAAC CGGCGGAACT 51GCCGCCGTTG CAAAATAATC CGCCATTTTA CCGTAAAAAC CGCCGCCTGA 101 ACTTTTTTATCGCGGCAGAC GGCGGTTGCG CGTCTCCGCA AAAATGCAGG 151 GCGCGCGGTT TTCAGACGGCATTTGCCGTT CAAAGCCGTG CGGTGTCTTT 201 ACCAAATGCC CAACCATTCG CCCACGGCATCCATCCAATC CTTATTGCCC 251 CCGCCGCTCC TGCCTGCTCG GCGGTACGCC CACGGCGCTTGCGGATTTTT 301 AGCTTTCCAC AATCCTTTGC GTTCCCTTTC CGCCTGAATT TGAGCGTCGG351 CATAATCGGC AAAATCCGCC TTATCCTGCT GTTCTTTAGC ATAACTTTTA 401TAATGCCACG CCGCCCCGTC CTGCACCTGC ATCAGGTTCA AATCGGTTTT 451 GCCGACAGAAACCTGCGCCA CTTCGCGCTG GTAGCGGTCG GTATCGAACA 501 CGCGCACGCT GACTTTCCTGCCTTCCGCCG CCGCGCGCAG GTTGTCGCGC 551 GAACGCGTGC CGTAAGCCTG TTTCATCTCCGGCGCGTCGA TATACGCCAT 601 CCGGATTTTG TGTTTCGCGC CGTCGCCGTC GATAACGTGAAGGGTGTCGC 651 CGTCATAGAC TTTGGACACC GTGCCTGTGT AGCGGTGGCC GGATTTCGCC701 GATGCTCGGC GGCGGGCGGG CGCGTCGGAA CCCGCGTCCC CTGCCGCGCC 751GAGTACGTCG AGTACGGCAA CCGCCGTCCG CACCGCCTCG CTGCCGTACC 801 CCGTATAACCCAACGCACCC AAAAGCGACA GGGCGACGGG AAGCCATTTC 851 ATGATTTTTT TAATCTGCATATTTTTCAAA TGCCGATGCC GTCTGAACAT 901 ATCGGAATCG GATTTCAGAC GGCATCTTAAThis corresponds to the amino acid sequence <SEQ ID 848; ORF 231-1>:

m231-1.pep 1 MSKRKSINRP YQKPAELPPL QNNPPFYRKN RRLNFFIAAD GGCASPQKCR 51ARGFQTAFAV QSRAVSLPNA QPFAHGIHPI LIAPAAPACS AVRPRRLRIF 101 SFPQSFAFPFRLNLSVGIIG KIRLILLFFS ITFIMPRRPV LHLHQVQIGF 151 ADRNLRHFAL VAVGIEHAHADFPAFRRRAQ VVARTRAVSL FHLRRVDIRH 201 PDFVFRAVAV DNVKGVAVID FGHRACVAVAGFRRCSAAGG RVGTRVPCRA 251 EYVEYGNRRP HRLAAVPRIT QRTQKRQGDG KPFHDFFNLHIFQMPMPSEH 301 IGIGFQTAS* g231-1/m231-1 87.0% identity in 262 aa overlap        10        20        30        40        50        60 g231-1.pepMSKRKSINRPYQKPAELPPLQNNPPFYRKNRRLNFFIAADGGCASPQKCRARGFQTAFAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m231-1MSKRKSINRPYQKPAELPPLQNNPPFYRKNRRLNFFIAADGGCASPQKCRARGFQTAFAV        10        20        30        40        50        60        70        80        90       100       110       120 g231-1.pepQGRAVSLPNAQPFAHGIHPILIAPAAPACPAVRPRRLRIFSFPQSFAFPFRLNLSVGIVG|:||||||||||||||||||||||||||| ||||||||||||||||||||||||||||:| m231-1QSRAVSLPNAQPFAHGIHPILIAPAAPACSAVRPRRLRIFSFPQSFAFPFRLNLSVGIIG        70        80        90       100       110       120       130       140       150       160       170       180 g231-1.pepKIRLILLFFSITFIMPRRPVLHLHQVQIGFAGGYLRHFALIAVGFKHLYNEFRTLRRRAQ|||||||||||||||||||||||||||||||   ||||||:|||::|:: :| ::||||| m231-1KIRLILLFFSITFIMPRRPVLHLHQVQIGFADRNLRHFALVAVGIEHAHADFPAFRRRAQ       130       140       150       160       170       180       190       200       210       220       230       240 g231-1.pepVVARTCTVSVFHLRCVDIRHPNFMFRAVAVDDVKGIAVIDFGHRACVAVAGFRXCPSANG||||| :||:|||| ||||||:|:|||||||:|||:||||||||||||||||| | :|:| m231-1VVARTRAVSLFHLRRVDIRHPDFVFRAVAVDNVKGVAVIDFGHRACVAVAGFRRCSAAGG       190       200       210       220       230       240       250       260 g231-1.pep CVETHVPCSAEYVVXGNRRPHR | |:||| ||||  ||||||| m231-1RVGTRVPCRAEYVEYGNRRPHRLAAVPRITQRTQKRQGDGKPFHDFFNLHIFQMPMPSEH       250       260       270       280       290       300The following partial DNA sequence was identified in N. meningitidis<SEQ ID 849>:

a231-1.seq 1 ATGTCAAAAC GAAAATCCAT AAACCGTCCG TATCAAAAAC CGGCGGAACT 51GCCGCCGTTG CAAAATAATC CGCCATTTTA CCGTAAAAAC CGCCGCCTGA 101 ACTTTTTTATCGCGGCAGAC GGCGGTTGCG CGTCTCCGCA AAAATGCAGG 151 GCGCGCGGTT TTCAGACGGCATTTGCCGTT CAAAGCCGTG CGGTGTCTTT 201 ACCAAATGCC CAACCATTCG CCCACGGCATCCATCCAATC CTTATTGCCC 251 CCGCCGCTCC TGCCTGCCCG GCGGTACGCC CACGGCGCTTGCGGATTTTT 301 AGCTTTCCAC AATCCTTTGC GTTCCCTTTC CGCCTGAATT TGAGCGTCGG351 CATAATCGGC AAAATCCGCC TTATCCTGCT GTTCTTTAGC ATAACTTTTA 401TAATGCCACG CCGCCCCGTC CTGCACCTGC ATCAGGTTCA AATCGGTTTT 451 GCCGACAGAAACCTGCGCCA CTTCGCGCTG GTAGCGGTCG GTGTCGAACA 501 CGCGGACGCT GACTTTCCTGCCTTCCGCCG CCGCGCGCAG GTTGTCGCGC 551 GAACGCGTGC CGTAAGCCTG TTTCATCTCCGGCGCGTCGA TATACGCCAT 601 CCGGATTTTG TGTTTCGCGC CGTCGCCGTC GATAACGTGAAGGGTGTCGC 651 CGTCATAGAC TTTGGACACC GTGCCTGTGT AGCGGTGGCC GGATTTCGCC701 GATGCTCGGC GGCGGGCGGG CGCGTCGGAA CCCGCGTCCC CTGCCGCGCC 751GAGTACGTCG AGTACGGCAA CCGCCGTCCG CACCGCCTCG CTGCCGTACC 801 CCGTATAACCCAACGCACCC AAAAGCGACA AGGCGACGGG AAGCCATTTC 851 ATGATTTTTT TAATCTGCATATTTTTCAAA TGCCGATGCC GTCTGAACAT 901 ATCGGAATCG GATTTCAGAC GGCATCTTAAThis corresponds to the amino acid sequence <SEQ ID 850; ORF 231-1.a>:

a231-1.pep 1 MSKRKSINRP YQKPAELPPL QNNPPFYRKN RRLNFFIAAD GGCASPQKCR 51ARGFQTAFAV QSRAVSLPNA QPFAHGIHPI LIAPAAPACP AVRPRRLRIF 101 SFPQSFAFPFRLNLSVGIIG KIRLILLFFS ITFIMPRRPV LHLHQVQIGF 151 ADRNLRHFAL VAVGVEHADADFPAFRRRAQ VVARTRAVSL FHLRRVDIRH 201 PDFVFRAVAV DNVKGVAVID FGHRACVAVAGFRRCSAAGG RVGTRVPCRA 251 EYVEYGNRRP HRLAAVPRIT QRTQKRQGDG KPFHDFFNLHIFQMPMPSEH 301 IGIGFQTAS* a231-1/m231-1 99.0% identity in 309 aa overlap        10        20        30        40        50        60 a231-1.pepMSKRKSINRPYQKPAELPPLQNNPPFYRKNRRLNFFIAADGGCASPQKCRARGFQTAFAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m231-1MSKRKSINRPYQKPAELPPLQNNPPFYRKNRRLNFFIAADGGCASPQKCRARGFQTAFAV        10        20        30        40        50        60        70        80        90       100       110       120 a231-1.pepQSRAVSLPNAQPFAHGIHPILIAPAAPACPAVRPRRLRIFSFPQSFAFPFRLNLSVGIIG||||||||||||||||||||||||||||| |||||||||||||||||||||||||||||| m231-1QSRAVSLPNAQPFAHGIHPILIAPAAPACSAVRPRRLRIFSFPQSFAFPFRLNLSVGIIG        70        80        90       100       110       120       130       140       150       160       170       180 a231-1.pepKIRLILLFFSITFIMPRRPVLHLHQVQIGFADRNLRHFALVAVGVEHADADFPAFRRRAQ||||||||||||||||||||||||||||||||||||||||||||:||| ||||||||||| m231-1KIRLILLFFSITFIMPRRPVLHLHQVQIGFADRNLRHFALVAVGIEHAHADFPAFRRRAQ       130       140       150       160       170       180       190       200       210       220       230       240 a231-1.pepVVARTRAVSLFHLRRVDIRHPDFVFRAVAVDNVKGVAVIDFGHRACVAVAGFRRCSAAGG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m231-1VVARTRAVSLFHLRRVDIRHPDFVFRAVAVDNVKGVAVIDFGHRACVAVAGFRRCSAAGG       190       200       210       220       230       240       250       260       270       280       290       300 a231-1.pepRVGTRVPCRAEYVEYGNRRPHRLAAVPRITQRTQKRQGDGKPFHDFFNLHIFQMPMPSEH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m231-1RVGTRVPCRAEYVEYGNRRPHRLAAVPRITQRTQKRQGDGKPFHDFFNLHIFQMPMPSEH       250       260       270       280       290       300        310a231-1.pep IGIGFQTASX |||||||||| m231-1 IGIGFQTASX        310The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 851>:

g232.seq 1 atgatgggca acagcctgat tgaatccggt acgtttgtcg ccatcctgtt 51tggtcagatt ttgggaacgg cggttgccgg cgcgccgcct tatattgtcg 101 ggatactggttttgctggtc gccgtcggag gaacggccgg cagcctgttt 151 atgccgtccg tacccgccaaggctgccgat acccaaatcg agtggaatat 201 tgtccgtggt acaaaatccc tgctgcgtgaaacggtgcgg cacaatcccg 251 tttttaccgc cattatcggc atctcgtggt tttggtttgtcggcgcggtt 301 tataccacgc aactgccgac ctttacccaa atccatttgg gcggcaacga351 taatgttttt aacctgatgc ttgctttgtt ttccatcggt attgccgccg 401gttcggtact gtgtgccaag ttcggcaggg aacggctgat gttggcttgg 451 gtaacggttggtgcgttggg ttcgacggtt tgcggcctgg ttttggtgtg 501 gctgacgcac ggacaccgttttgaagggct gaacggcatt ttttggtttt 551 tatcgcaagg atgggcatac cccgtgatggcggtgatgac gctgatcggc 601 tttttcggcg gatttttctc cgttccgctc tatacctggctgcaaaccgc 651 cagcagcgag actttccgcg cccgcgccgt tgccgccaac aatatcgtta701 acggcatctt tatggtttcc gccgccgttt tgagcgcggt attgctgttt 751ttgtttgaca gcatttccct gctgtatctg attgtcgcct tgggcaatat 801 tccgttggcggtatttttga ttaagcgcga aaggcggttt ttaggcgcgg 851 cggcaatcag gaaaaaaccttgaThis corresponds to the amino acid sequence <SEQ ID 852; ORF 232.ng>:

g232.pep 1 MMGNSLIESG TFVAILFGQI LGTAVAGAPP YIVGILVLLV AVGGTAGSLF 51MPSVPAKAAD TQIEWNIVRG TKSLLRETVR HNPVFTAIIG ISWFWFVGAV 101 YTTQLPTFTQIHLGGNDNVF NLMLALFSIG IAAGSVLCAK FGRERLMLAW 151 VTVGALGSTV CGLVLVWLTHGHRFEGLNGI FWFLSQGWAY PVMAVMTLIG 201 FFGGFFSVPL YTWLQTASSE TFRARAVAANNIVNGIFMVS AAVLSAVLLF 251 LFDSISLLYL IVALGNIPLA VFLIKRERRF LGAAAIRKKP *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 853>:

m232.seq 1 ATGATGGGCA ACAGCCTGAT TGAATCGGGT ACGTTTGTCG CCATCCTGTT 51CGGTCAGATT TTGGGAACGG CGGTGGCAGG TGTACCGCCT TATATTGTCG 101 GGATACTGGTTTTGCTGGTC GCCGTCGGAG GCACGGTCGG CAGCCTGTTT 151 ATGCCGTCCG TACCCGCCAAGGCTGCCGAT ACACAAATTG AGTGGAATAT 201 TGTCCGTGGC ACAAAATCCC TGCTGCGTGAAACGGTGCGG CACAAGCCCG 251 TTTTTACCGC CATTATCGGT ATTTCGTGGT TTTGGTTTGTCGGCGCGGTT 301 TATACCACGC AACTGCCGAC CTTTACCCAA ATCCATCTGG GCGGCAACGA351 CAATGTTTTC AACCTGATGC TTGCTCTGTT TTCCATCGGT ATTGCCGCCG 401GTTCGGTACT GTGTGCCAAG TTCAGCAkGG AACGCCTGAT GTTGGCTTGG 451 GTAACGGTTGGTGCGTTGGG TTTGACGGTT TGCGGCTTGG TTTTGGTGTG 501 GCTGACGCAC GGACACCGTTTTGAAGGGCT GAACGGCATT TTTTrGTTTT 551 TATCGCAAGG ATGGGCATAT CCCGTGATGGCGGTGATGAC GCTGATCGGC 601 TTTTTCGGCG GATTTTTCTC CGTTCCGCTC TATACCt(g)TGCAAACCGCCa 651 TAGCGAGaTT TCCGCGCCCg GCCGTTGCCG CCAACAATAT CGTTAACGGT701 ATTTTTATGG TTTCCGCTGC CGTTTTGAGC GCGGTGTTGC TGTTTTTGTT 751TGACAGCATT TCCTTGTTGT ATCTGATTGT CGCTTTGGGC AATATTCCGT 801 TGTCGGTATTTTTGATTAAG CGCGAAAGGC GGTTTTTAGG CGCGGCGGCA 851 ATCAGGAAAA AACCTTGAThis corresponds to the amino acid sequence <SEQ ID 854; ORF 232>:

m232.pep 1 MMGNSLIESG TFVAILFGQI LGTAVAGVPP YIVGILVLLV AVGGTVGSLF 51MPSVPAKAAD TQIEWNIVRG TKSLLRETVR HKPVFTAIIG ISWFWFVGAV 101 YTTQLPTFTQIHLGGNDNVF NLMLALFSIG IAAGSVLCAK FSXERLMLAW 151 VTVGALGLTV CGLVLVWLTHGHRFEGLNGI FXFLSQGWAY PVMAVMTLIG 201 FFGGFFSVPL YTVQTAIARF PRPAVAANNIVNGIFMVSAA VLSAVLLFLF 251 DSISLLYLIV ALGNIPLSVF LIKRERRFLG AAAIRKKP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 232 shows 94.1% identity over a 290 aa overlap with a predicted ORF(ORF 232.ng) from N. gonorrhoeae:

m232/g232          10        20        30        40        50        60m232.pep  MMGNSLIESGTFVAILFGQILGTAVAGVPPYIVGILVLLVAVGGTVGSLFMPSVPAKAAD |||||||||||||||||||||||||||:|||||||||||||||||:|||||||||||||| g232 MMGNSLIESGTFVAILFGQILGTAVAGAPPYIVGILVLLVAVGGTAGSLFMPSVPAKAAD         10        20        30        40        50        60         70        80        90       100       110       120 m232.pep TQIEWNIVRGTKSLLRETVRHKPVFTAIIGISWFWFVGAVYTTQLPTFTQIHLGGNDNVF |||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| g232 TQIEWNIVRGTKSLLRETVRHNPVFTAIIGISWFWFVGAVYTTQLPTFTQIHLGGNDNVF         70        80        90       100       110       120        130       140       150       160       170       180 m232.pep NLMLALFSIGIAAGSVLCAKFSXERLMLAWVTVGALGLTVCGLVLVWLTHGHRFEGLNGI |||||||||||||||||||||: |||||||||||||| |||||||||||||||||||||| g232 NLMLALFSIGIAAGSVLCAKFGRERLMLAWVTVGALGSTVCGLVLVWLTHGHRFEGLNGI        130       140       150       160       170       180        190       200       210       220       230 m232.pep FXFLSQGWAYPVMAVMTLIGFFGGFFSVPLYT-VQTAIARFPRP-AVAANNIVNGIFMVS | |||||||||||||||||||||||||||||| :||| ::  |  ||||||||||||||| g232 FWFLSQGWAYPVMAVMTLIGFFGGFFSVPLYTWLQTASSETFRARAVAANNIVNGIFMVS        190       200       210       220       230       240240       250       260       270       280      289 m232.pep AAVLSAVLLFLFDSISLLYLIVALGNIPLSVFLIKRERRFLGAAAIRKKPX |||||||||||||||||||||||||||||:|||||||||||||||||||| g232 AAVLSAVLLFLFDSISLLYLIVALGNIPLAVFLIKRERRFLGAAAIRKKP        250       260       270       280       290The following partial DNA sequence was identified in N. meningitidis<SEQ ID 855>:

a232.seq 1 ATGTACGCTA AAAAAGGCGG TTTGGGACTG GTTAAAAGCC GCCGTTTCGC 51ACCTCTTTTC GCTACGCAGT TTCTCGGCGC GTTCAACGAC AATGTGTTCA 101 AAACCGCGCTGTTTGTGATG ATTGGGTTTT ACGGTTTGGG GCAAAACGGC 151 TTCCTGCCTG CCGGACAGATGTTGAACTTG GGCGCGTTGC TGTTTATTTT 201 GCCGTATTTC CTGTTTTCCT CGCTGTCGGGGCAGTTGGGT AACAAATTCG 251 ACAAGGCCGT TTTGGCGCGT TGGGCCAAGG TGCTGGAAATGATCATTATG 301 GCGGTGGCGG CATACGGGTT TTATATCCGG TCTGCCCCGC TGCTTTTGGC351 GTGTCTGTTT TGCATGGGCG CGCAATCGAC GCTGTTCGGG CCGCTGAAAT 401ACGCCATCCT GCCCGATTAT CTCGACGACA AAGAGTTGAT GATGGGCAAC 451 AGCCTGATTGAATCGGGTAC GTTTGTCGCC ATCCTGTTCG GTCAGATACT 501 GGGGACTGCG GTGGCAGGTGTACCGCCTTA TATTGTCGGG ATACTGGTTT 551 TGCTGGTCGC CGTAGGAGGC ACGGTCGGCAGCCTGTTTAT GCCGTCCGTA 601 CCCGCCAAGG CTGCCGATAC ACAAATTGAG TGGAATATTGTCCGGGGTAC 651 AAAATCCCTG CTGCGTGAAA CGGTGCGGCA CAAGCCCGTT TTTACCGCCA701 TTATCGGTAT TTCGTGGTTT TGGTTTGTCG GCGCGGTTTA TACCACGCAA 751CTGCCGACCT TTACCCAAAT CCATCTAGGC GGCAACGACA ATGTTTTCAA 801 CCTGATGCTTGCCCTGTTTT CCATCGGTAT TGCCGCCGGT TCGGTACTGT 851 GTGCCAAGTT CAGCAGGGAACGGCTGAGGT TGGCTTGGGT AACGGTTGGT 901 GCGTTGGGTT TGACGGTTTG CGGCTTGGTTTTGGTGTGGC TGACGCACGG 951 ACACCGTTTT GAAGGGCTGA ACGGCATTTT TTGGTTTTTATCGCAAGGAT 1001 GGGCATATCC CGTGATGGCG GTGATGACGC TGATCGGCTT TTTCGGCGGA1051 TTTTTCTCCG TTCCGCTCTA TACCTGGCTG CAAACCGCCA GTAGCGAGAC 1101TTTCCGCGCC CGCGCCGTTG CCGCCAACAA TATCGTTAAC GGTATTTTTA 1151 TGGTTTCCGCTGCCGTTTTG AGCGCGGTGT TGCTGTTTTT GTTTGACAGC 1201 ATTTCCTTGT TGTATCTGATTGTCGCTTTG GGCAATATTC CGTTGTCGGT 1251 ATTTTTGATT AAGCGCGAAA GGCGGTTTTTAGGCGCGGCG GCAATCAGGA 1301 AAAAACCTTG AThis corresponds to the amino acid sequence <SEQ ID 856; ORF 232.a>:

a232.pep 1 MYAKKGGLGL VKSRRFAPLF ATQFLGAFND NVFKTALFVM IGFYGLGQNG 51FLPAGQMLNL GALLFILPYF LFSSLSGQLG NKFDKAVLAR WAKVLEMIIM 101 AVAAYGFYIRSAPLLLACLF CMGAQSTLFG PLKYAILPDY LDDKELMMGN 151SLIESGTFVA ILFGQILGTA VAGVPPYIVG ILVLLVAVGG TVGSLFMPSV 201 PAKAADTQIEWNIVRGTKSL LRETVRHKPV FTAIIGISWF WFVGAVYTTQ 251 LPTFTQIHLGGNDNVFNLML ALFSIGIAAG SVLCAKFSRE RLRLAWVTVG 301 ALGLTVCGLV LVWLTHGHRFEGLNGIFWFL SQGWAYPVMA VMTLIGFFGG 351 FFSVPLYTWL QTASSETFRA RAVAANNIVNGIFMVSAAVL SAVLLFLFDS 401 ISLLYLIVAL GNIPLSVFLI KRERRFLGAA AIRKKP*m232/a232 95.9% identity in 290 aa overlap                                       10        20        30 m232.pep                               MMGNSLIESGTFVAILFGQILGTAVAGVPP                               |||||||||||||||||||||||||||||| a232 ACLFCMGAQSTLFGPLKYAILPDYLDDKELMMGNSLIESGTFVAILFGQILGTAVAGVPP  120       130       140       150       160       170         40        50        60        70        80        90 m232.pep YIVGILVLLVAVGGTVGSLFMPSVPAKAADTQIEWNIVRGTKSLLRETVRHKPVFTAIIG |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a232 YIVGILVLLVAVGGTVGSLFMPSVPAKAADTQIEWNIVRGTKSLLRETVRHKPVFTAIIG  180       190       200       210       220       230        100       110       120       130       140       150 m232.pep ISWFWFVGAVYTTQLPTFTQIHLGGNDNVFNLMLALFSIGIAAGSVLCAKFSXERLMLAW |||||||||||||||||||||||||||||||||||||||||||||||||||| ||| ||| a232 ISWFWFVGAVYTTQLPTFTQIHLGGNDNVFNLMLALFSIGIAAGSVLCAKFSRERLRLAW  240       250       260       270       280       290        160       170       180       190       200       210 m232.pep VTVGALGLTVCGLVLVWLTHGHRFEGLNGIFXFLSQGWAYPVMAVMTLIGFFGGFFSVPL ||||||||||||||||||||||||||||||| |||||||||||||||||||||||||||| a232 VTVGALGLTVCGLVLVWLTHGHRFEGLNGIFWFLSQGWAYPVMAVMTLIGFFGGFFSVPL  300       310       320       330       340       350         220        230       240       250       260 m232.pep YT-VQTAIARFPRP-AVAANNIVNGIFMVSAAVLSAVLLFLFDSISLLYLIVALGNIPLS || :||| ::  |  ||||||||||||||||||||||||||||||||||||||||||||| a232 YTWLQTASSETFRARAVAANNIVNGIFMVSAAVLSAVLLFLFDSISLLYLIVALGNIPLS  360       370       380       390       400       410270       280      289 m232.pep  VFLIKRERRFLGAAAIRKKPX ||||||||||||||||||||| a232  VFLIKRERRFLGAAAIRKKPX   420       430The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 857>:

g233.seq 1 atgaaacgca aaaatatcgc gctgattccc gccgccggca tcggggtgcg 51tttcggtgcg gacaaaccca agcaatatgt cgaaatcgga agcaaaaccg 101 ttttagaacatgtacttggg atttttgaac ggcatgaggc cgtcgatttg 151 accgtcgttg tcgtctcgcccgaagacacg tttgccgata aggttcagac 201 ggcatttcca caggttcggg tgtggaaaaacggtggacag acccgcgccg 251 aaactgtccg caacggtgtg gcaaaactgt tggaaaccggtttggcggcg 301 gaaaccgaca atattctggt acacgatgcc gcccgctgct gcctgccgtc351 tgaagctctg gcgcggttga tagaacaggc gggcaacgcc gccgaaggcg 401ggattttggc agttcccgtt gccgatacgc tcaagcgcgc agaaagcgga 451 caaatcagtgcaactgtcga ccgttcgggg ctttggcagg cgcaaacgcc 501 gcagcttttt caagcgggtttgctgcaccg cgcattggct gcggaaaact 551 tgggcggcat taccgatgaa gcgtccgccgtggaaaaact gggtgtgcgt 601 ccgctactga tacagggcga cgcgcgcaat ttgaaactgacgcagccgca 651 ggacgcatac atcgtcaggc tgctgctcaa tgccgtctgaThis corresponds to the amino acid sequence <SEQ ID 858; ORF 233.ng>:

g233.pep 1 MKRKNIALIP AAGIGVRFGA DKPKQYVEIG SKTVLEHVLG IFERHEAVDL 51TVVVVSPEDT FADKVQTAFP QVRVWKNGGQ TRAETVRNGV AKLLETGLAA 101 ETDNILVHDAARCCLPSEAL ARLIEQAGNA AEGGILAVPV ADTLKRAESG 151 QISATVDRSG LWQAQTPQLFQAGLLHRALA AENLGGITDE ASAVEKLGVR 201 PLLIQGDARN LKLTQPQDAY IVRLLLNAV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 859>:

m233.seq (partial) 1 ATGAAGCGCA AAAATATCGC GCTGATTCCC GCCGCCGGCATCGGGGCGCG 51 TTTCGGTGCG GACAAACCCA AGCAATATGT CGAAATCGGA AGCAAAACCG 101TTTTAGAACA TACGATTGGG ATTTTTGAAC GGCATGAGGC CGTCGATTTG 151 ACCGTCGTTGTCGTCTCGCC CGAAGACACG TTTGCCGATA AGGTTCAGAC 201 GGCATTTCCA CAGGTTCGGGTGTGGAAAAA CGGCGGACAG ACCCGCGCCG 251 AAACCGTCCG CAACGGTGTG GCAAAACTGTTGGAAACCGG TTTGGCGGCG 301 GAAACCGACA ATATTCTGGT ACACGATGCC GCGCGTTGCTGCCTGCCGTC 351 TGAAGCTTTG ACGCGGTTGA TAGAACAGGC GGGCAACGCC GCCGAAGGCG401 GGATTTTGGC AATTCCCATT GCCGATACGC TCAAGTGCGC GGACGGTGGG 451AACATT....This corresponds to the amino acid sequence <SEQ ID 860; ORF 233>:

m233.pep (partial) 1 MKRKNIALIP AAGIGARFGA DKPKQYVEIG SKTVLEHTIGIFERHEAVDL 51 TVVVVSPEDT FADKVQTAFP QVRVWKNGGQ TRAETVRNGV AKLLETGLAA 101ETDNILVHDA ARCCLPSEAL TRLIEQAGNA AEGGILAIPI ADTLKCADGG 151 NI....Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 233 shows 93.4% identity over a 152 aa overlap with a predicted ORF(ORF 233.ng) from N. gonorrhoeae:

m233/g233         10        20        30        40        50        60m233.pep MKRKNIALIPAAGIGARFGADKPKQYVEIGSKTVLEHTIGIFERHEAVDLTVVVVSPEDT|||||||||||||||:|||||||||||||||||||||::||||||||||||||||||||| g233MKRKNIALIPAAGIGVRFGADKPKQYVEIGSKTVLEHVLGIFERHEAVDLTVVVVSPEDT        10        20        30        40        50        60        70        80        90       100       110       120 m233.pepFADKVQTAFPQVRVWKNGGQTRAETVRNGVAKLLETGLAAETDNILVHDAARCCLPSEAL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g233FADKVQTAFPQVRVWKNGGQTRAETVRNGVAKLLETGLAAETDNILVHDAARCCLPSEAL        70        80        90       100       110       120       130       140       150 m233.pep TRLIEQAGNAAEGGILAIPIADTLKCADGGNI:||||||||||||||||:|:||||| |::|:| g233ARLIEQAGNAAEGGILAVPVADTLKRAESGQISATVDRSGLWQAQTPQLFQAGLLHRALA       130       140       150       160       170       180The following partial DNA sequence was identified in N. meningitidis<SEQ ID 861>:

a233.seq 1 ATGAAGCGCA AAAATATCGC GCTGATTCCC GCCGCCGGCA TCGGGGCGCG 51TTTCGGTGCG GACAAACCCA AGCAATATGT CGAAATCGGA AGCAAAACCG 101 TTTTAGAACATACGATTGGG ATTTTTGAAC GGCATGAGGC CGTCGATTTG 151 ACCGTCGTTG TCGTCTCGCCCGAAGACACG TTTGCCGATA AGGTTCAGAC 201 GGCATTTCCA CAGGTTCGGG TGTGGAAAAACGGCGGACAG ACCCGCGCCG 251 AAACTGTCCG CAACGGTGTG GCAAAATTGT TGGAAACCGGTTTGGCGGCG 301 GAAACCGACA ATATTCTGGT ACACGATGCC GCGCGTTGCT GCCTGCCGTC351 TGAAGCTTTG ACGCGGTTGA TAGAACAGGC GGGCAACGCT GCCGAAGGTG 401GGATTTTGGC AATTCCCGTT GCCGATACGC TCAAGTGCGC GGACGGTGGG 451 AACATTAGTGCAACCGTCGA GCGGACGAGC CTTTGGCAGG CGCAAACGCC 501 GCAGCTTTTC CGCGCCGGGCTGCTGCACCG CGCATTGGCT GCGGAAAACT 551 TGGACGGCAT TACCGATGAA GCGTCCGCCGTGGAAAAATT GGGCATCCGC 601 CCTTTGCTGG TGCAGGGCGA CGCGCGCAAT TTGAAACTGACGCAGCCGCA 651 GGACGCATAC ATCGTCAGGC TGCTGCTCGA TGCCGTCTGAThis corresponds to the amino acid sequence <SEQ ID 862; ORF 233.a>:

a233.pep 1 MKRKNIALIP AAGIGARFGA DKPKQYVEIG SKTVLEHTIG IFERHEAVDL 51TVVVVSPEDT FADKVQTAFP QVRVWKNGGQ TRAETVRNGV AKLLETGLAA 101 ETDNILVHDAARCCLPSEAL TRLIEQAGNA AEGGILAIPV ADTLKCADGG 151 NISATVERTS LWQAQTPQLFRAGLLHRALA AENLDGITDE ASAVEKLGIR 201 PLLVQGDARN LKLTQPQDAY IVRLLLDAV*m233/a233 99.3% identity in 152 aa overlap        10        20        30        40        50        60 m233.pepMKRKNIALIPAAGIGARFGADKPKQYVEIGSKTVLEHTIGIFERHEAVDLTVVVVSPEDT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a233MKRKNIALIPAAGIGARFGADKPKQYVEIGSKTVLEHTIGIFERHEAVDLTVVVVSPEDT        10        20        30        40        50        60        70        80        90       100       110       120 m233.pepFADKVQTAFPQVRVWKNGGQTRAETVRNGVAKLLETGLAAETDNILVHDAARCCLPSEAL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a233FADKVQTAFPQVRVWKNGGQTRAETVRNGVAKLLETGLAAETDNILVHDAARCCLPSEAL        70        80        90       100       110       120       130       140       150 m233.pep TRLIEQAGNAAEGGILAIPIADTLKCADGGNI|||||||||||||||||||:|||||||||||| a233TRLIEQAGNAAEGGILAIPVADTLKCADGGNISATVERTSLWQAQTPQLFRAGLLHRALA       130       140       150       160       170       180 a233AENLDGITDEASAVEKLGIRPLLVQGDARNLKLTQPQDAYIVRLLLDAVX       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 863>:

g234.seq 1 atgaaaaccg tttccgccgc catcgctttt gccgccgctg ccgtttcact 51gaccggctgt gcgaccgagt cctcacgcag cctcgaggtt gcaaaagtcg 101 cctcctgcaatacgcaatat cacggtgttc gcaccccgat ttccgtcgga 151 acattcgaca accgctccagcttccaaaaa ggcattttct ccgacagtga 201 agaccgtctg ggcagccagg caaaaaccatcctggtaaca cacctgcaac 251 aaaccaaccg cttcaacgta ctgaaccgca ccaaccttagcgcattgaaa 301 caggaatccg gcatttccgg caaagcgcag aacctgaaag gcgcagatta351 tgtcgttacc ggcgatgtaa ccgaattcgg acgcagagat gtcggcgatc 401atcagctctt cggcattttg ggtcgcggca aatcgcaaat cgcctatgca 451 aaagtggctctgaatatcgt caacgtcaat acttccgaaa tcgtctattc 501 cacacagggc gcgggcgaatacgcactttc caaccgcgaa atcatcggtt 551 tcggcggcac ttccggctac gatgcgactttgaacggcaa agttttagac 601 ttggcaatcc gcgaagccgt cgacaacttg gttcaggctgtcgacaacgg 651 cgcatggcaa tccaaccgtt aaThis corresponds to the amino acid sequence <SEQ ID 864; ORF 234.ng>:

g234.pep 1 MKTVSAAIAF AAAAVSLTGC ATESSRSLEV AKVASCNTQY HGVRTPISVG 51TFDNRSSFQK GIFSDSEDRL GSQAKTILVT HLQQTNRFNV LNRTNLSALK 101 QESGISGKAQNLKGADYVVT GDVTEFGRRD VGDHQLFGIL GRGKSQIAYA 151 KVALNIVNVN TSEIVYSTQGAGEYALSNRE IIGFGGTSGY DATLNGKVLD 201 LAIREAVDNL VQAVDNGAWQ SNR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 865>:

m234.seq (partial) 1 ...GGCGCGGGCG AATACGCACT TTCCAACCGt GAAATCATCGGTTTCGGCGG 51    CACTTCCGGC TACGATGCGA CTTTGAACGG CAAAGTTTTA GACTTGGCAA101    TCCGCGAAGC .gTCAACAGC CTGGTTCAGG CTGTTGACAA CGGCGCATGG 151   CAACCCAACC GTTAAThis corresponds to the amino acid sequence <SEQ ID 866; ORF 234>:

m234.pep (partial) 1 ..GAGEYALSNR EIIGFGGTSG YDATLNGKVL DLAIREAVNSLVQAVDNGAW 51   QPNR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 234 shows 94.4% identity over a 54 aa overlap with a predicted ORF(ORF 234.ng) from N. gonorrhoeae:

m234/g234                                         10        20        30m234.pep                                 GAGEYALSNREIIGFGGTSGYDATLNGKVL                                |||||||||||||||||||||||||||||| g234  LGRGKSQIAYAKVALNIVNVNTSEIVYSTQGAGEYALSNREIIGFGGTSGYDATLNGKVL140       150       160       170       180       190          40        50 m234.pep   DLAIREAVNSLVQAVDNGAWQPNRX  ||||||||::||||||||||| ||| g234   DLAIREAVDNLVQAVDNGAWQSNRX200       210       220The following partial DNA sequence was identified in N. meningitidis<SEQ ID 867>:

a234.seq (partial) 1 AACCGCACCT ATTTGAACGC ATTAAAACAG GAATCCGGCATTTCCGGCAA 51 AGCGCATAAC CTGAAAGGCG CAAATTATGT CGNNACCGGC GATGTAACCG 101AATTCGGACG CANAGATGTC GGCGATCATC AGCTCTTCGG CATTTTGGGT 151 CGCGGCAAATCGCAAATCGC CTATGCAAAA GTGGCTCTGA ATATCGTCAA 201 CGTCAATACT TCCGAAATCGTCTATTCCGC ACAGGGCGCG GGCGAATACG 251 CACTTTCCAA CCGTGAAATC ATCGGTTTCGGCGGCACTTC CGGCTACGAT 301 GCGACTTTGA ACGGCAAAGT TTTAGACTTG GCAATCCGCGAAGCCGTCAA 351 CAGCCTGGTT CAGGCTGTTG ACAACGGCGC ATGGCAACCC AACCGTTAAThis corresponds to the amino acid sequence <SEQ ID 868; ORF 234.a>:

a234.pep (partial) 1 NRTYLNALKQ ESGISGKAHN LKGANYVXTG DVTEFGRXDVGDHQLFGILG 51 RGKSQIAYAK VALNIVNVNT SEIVYSAQGA GEYALSNREI IGFGGTSGYD 101ATLNGKVLDL AIREAVNSLV QAVDNGAWQP NR* m234/a234 100.0% identity in 54 aaoverlap                                        10        20        30m234.pep                                GAGEYALSNREIIGFGGTSGYDATLNGKVL                               |||||||||||||||||||||||||||||| a234 LGRGKSQIAYAKVALNIVNVNTSEIVYSAQGAGEYALSNREIIGFGGTSGYDATLNGKVL 50        60        70        80        90       100         40        50 m234.pep  DLAIREAVNSLVQAVDNGAWQPNRX ||||||||||||||||||||||||| a234  DLAIREAVNSLVQAVDNGAWQPNRX110       120       130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 869>:

g235.seq 1 atgaaacctt tgattttagg gcttgccgcc gtgttggctc tgtctgcctg 51ccaagttcga aaagctcccg acctcgacta cacgtcattc aaagaaagca 101 aaccggcttcaattttggtg gttccgccgc tgaacgagtc gcctgatgtc 151 aacggcactt gggggatgctggcttcgacc gccgcgccga tttccgaagc 201 cggctattac gtctttcccg ccgcagtcgtggaggaaacc ttcaaagaaa 251 acggcttgac caatgccgcc gatattcacg ccgtccggccggaaaaactg 301 catcaaattt tcggcaatga tgcggttttg tacattacgg ttaccgaata351 cggcacttca tatcaaattt tagacagcgt gacgaccgta tccgccaaag 401cacggctggt cgattcccgc aacgggaaag agttgtggtc gggttcggcc 451 agcatccgcgaaggcagcaa caacagcaac agcggcctgt tgggggcttt 501 ggtcggcgca gtggtcaatcagattgccaa cagcctgacc gaccgcggtt 551 atcaggtttc caaaaccgcc gcatacaacctactgtcgcc ctattcccgc 601 aacggtatct tgaaaggtcc gagattcgtc gaagagcagcccaaataaThis corresponds to the amino acid sequence <SEQ ID 870; ORF 235.ng>:

g235.pep 1 MKPLILGLAA VLALSACQVR KAPDLDYTSF KESKPASILV VPPLNESPDV 51NGTWGMLAST AAPISEAGYY VFPAAVVEET FKENGLTNAA DIHAVRPEKL 101 HQIFGNDAVLYITVTEYGTS YQILDSVTTV SAKARLVDSR NGKELWSGSA 151 SIREGSNNSN SGLLGALVGAVVNQIANSLT DRGYQVSKTA AYNLLSPYSR 201 NGILKGPRFV EEQPK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 871>:

m235.seq 1 ATGAAACCTT TGATTTTAGG GCTTGCCGCC GTGTTGGCGC TGTCTGCCTG 51CCAAGTTCAA AAAGCGCCCG ATTTCGACTA CACGTCATTC AAGGAAAGCA 101 AACCGGCTTCAATTTTGGTG GTTCCGCCGC TGAACGAATC GCCCGATGTC 151 AACGGAACAT GGGGTGTACTGGCTTCGACC GCCGCGCCGC TTTCCGAAGC 201 CGGCTATTAC GTCTTCCCCG CCGCAGTCGTGGAGGAAACC TTCAAACAAA 251 ACGGCTTGAC CAATGCCGCC GATATTCACG CCGTCCGGCCGGAAAAACTG 301 CATCAGATTT TCGGCAATGA TGCGGTTTTG TACATTACGG TTACCGAATA351 CGGCACTTCA TATCAAATTT TAGACAGCGT GACGACCGTA TCCGCCAAAG 401CACGGCTGGT CGATTCCCGC AACGGAAAAG AGTTGTGGTC GGGTTCGGCC 451 AGCATCCGCGAAGGCAGCAA CAACAGCAAC AGCGGCCTGT TGGGGGCTTT 501 GGTCAGCGCA GTGGTCAATCAGATTGCCAA CAGCCTGACC GACCGCGGTT 551 ATCAGGTTTC CAAAACCGCC GCATACAACCTGCTGTCGCC CTATTCTCAC 601 AACGGCATCT TGAAAGGTCC GAGATTCGTT GAAGAGCAGCCCAAATAAThis corresponds to the amino acid sequence <SEQ ID 872; ORF 235>:

m235.pep 1 MKPLILGLAA VLALSACQVQ KAPDFDYTSF KESKPASILV VPPLNESPDV 51NGTWGVLAST AAPLSEAGYY VFPAAVVEET FKQNGLTNAA DIHAVRPEKL 101 HQIFGNDAVLYITVTEYGTS YQILDSVTTV SAKARLVDSR NGKELWSGSA 151 SIREGSNNSN SGLLGALVSAVVNQIANSLT DRGYQVSKTA AYNLLSPYSH 201 NGILKGPRFV EEQPK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 235 shows 96.7% identity over a 215 aa overlap with a predicted ORF(ORF 235.ng) from N. gonorrhoeae:

m235/g235         10        20        30        40        50        60m235.pep MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLAST|||||||||||||||||||:||||:||||||||||||||||||||||||||||||:|||| g235MKPLILGLAAVLALSACQVRKAPDLDYTSFKESKPASILVVPPLNESPDVNGTWGMLAST        10        20        30        40        50        60        70        80        90       100       110       120 m235.pepAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTS|||:||||||||||||||||||:||||||||||||||||||||||||||||||||||||| g235AAPISEAGYYVFPAAVVEETFKENGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTS        70        80        90       100       110       120       130       140       150       160       170       180 m235.pepYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLT||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||| g235YQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVGAVVNQIANSLT       130       140       150       160       170       180       190       200       210 m235.pepDRGYQVSKTAAYNLLSPYSHNGILKGPRFVEEQPKX|||||||||||||||||||:|||||||||||||||| g235DRGYQVSKTAAYNLLSPYSRNGILKGPRFVEEQPKX        190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 873>:

a235.seq 1 ATGAAACCTT TGATTTTAGG GCTTGCCGCC GTGTTGGCGC TGTCTGCCTG 51CCAAGTTCAA AAAGCGCCCG ATTTCGACTA CACGTCATTC AAGGAAAGCA 101 AACCGGCTTCAATTTTGGTG GTTCCGCCGC TGAACGAATC GCCCGATGTC 151 AACGGAACAT GGGGTGTACTGGCTTCGACC GCCGCGCCGC TTTCCGAAGC 201 CGGCTATTAC GTCTTCCCCG CCGCAGTCGTGGAGGAAACC TTCAAACAAA 251 ACGGCTTGAC CAATGCCGCC GATATTCACG CCGTCCGGCCGGAAAAACTG 301 CATCAGATTT TCGGCAATGA TGCGGTTTTG TACATTACGG TTACCGAATA351 CGGCACTTCA TATCAAATTT TAGACAGCGT GACGACCGTA TCCGCCAAAG 401CACGGCTGGT CGATTCCCGC AACGGAAAAG AGTTGTGGTC GGGTTCGGCC 451 AGCATCCGCGAAGGCAGCAA CAACAGCAAC AGCGGCCTGT TGGGGGCTTT 501 GGTCAGCGCA GTGGTCAATCAGATTGCCAA CAGCCTGACC GACCGCGGTT 551 ATCAGGTTTC TAAAACCGCC GCATACAACCTGCTGTCGCC CTATTCTCAC 601 AACGGCATCT TGAAAGGTCC GAGATTCGTC GAAGAGCAGCCCAAATAAThis corresponds to the amino acid sequence <SEQ ID 874; ORF 235.a>:

a235.pep 1 MKPLILGLAA VLALSACQVQ KAPDFDYTSF KESKPASILV VPPLNESPDV 51NGTWGVLAST AAPLSEAGYY VFPAAVVEET FKQNGLTNAA DIHAVRPEKL 101 HQIFGNDAVLYITVTEYGTS YQILDSVTTV SAKARLVDSR NGKELWSGSA 151 SIREGSNNSN SGLLGALVSAVVNQIANSLT DRGYQVSKTA AYNLLSPYSH 201 NGILKGPRFV EEQPK* m235/a235 100.0%identity in 215 aa overlap        10        20        30        40        50        60 m235.pepMKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLAST|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a235MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGVLAST        10        20        30        40        50        60        70        80        90       100       110       120 m235.pepAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a235AAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTS        70        80        90       100       110       120       130       140       150       160       170       180 m235.pepYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a235YQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVSAVVNQIANSLT       130       140       150       160       170       180       190       200       210 m235.pepDRGYQVSKTAAYNLLSPYSHNGILKGPRFVEEQPKX|||||||||||||||||||||||||||||||||||| a235DRGYQVSKTAAYNLLSPYSHNGILKGPRFVEEQPKX        190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 875>:

g236.seq 1 ATGGCGCGTT TCGCCTTCTC CGCCGACATT CTCCGCACAG CGTTTGCAGA 51CGGTTTCATA ACCTGCAACC GCGCCCACAT CGCGGGTGTA ATGCCAGCAG 101 CGTTCGCATTTTTCGCCGTC GCTGGCTTTG GCGGCAACGG CAAGTTCATC 151 ACCGACTTTC ACTTCTGCTTTAGACACCAG CAGGGCAAAG CGCAATTCTT 201 CGCCCAAAGC ATTCAGATAG CCGGCCATTTCTTCCGGCGC GGTAATTTCG 251 GCTTCCGCCT GCAAggacga accgacagTT TTGTcggcGCGCAAAGGCTC 301 GAtagcggcg gTTACTGCTT CGCGCGCTTC GCGGATTGCC GTCCATTTTT351 TCACCAGTTC GGCTTCGGCT TTTTCGTTGA TGGCCGGGAA CTCGTGCCAA 401GTATGGAAGA GGACGCTGTC TTCTTCGCCG CCGCCGATGA TGTCCCACGC 451 TTCTTCGCCGGTGAAGCACA AAATCGGTGC AATCAAGAGA ACCAGGCTGC 501 GCGTGATGTG GTACAGGGCGGTTTGCGCGC TGCGGCGGGC GCGGCTGTCG 551 GCTTTGGTGG TGTAGAGGCG GTCTTTCAGGATGTCGAGGT AGAACGCGCC 601 CAAGTCTTCC GAGCAGAAAG AAACAATGTC TTTCACGGCGAAGTGGAAGG 651 CATAGCGCGG ATAGTAACCG CCTGCCAAAC GCTCTTGCAG CCGCCGCGCC701 AATACCAAGG CGTAGCGGTC GATTTCCACC ATATCCGCCT GTTGCACGGC 751ATCTTCAATC GGATTAAAGT CGCTCAAATT GGCAAAcagG AAGCTCAAGG 801 TATTGCGGATGCGGCGGTAG CTTTCGGTAA CGCGTTTGAG GATTTCTTTG 851 GAAatcgCCA ATtcgccgctgTAATCGGTG GATGCCGCCC ACAGGCGCAG 901 GATGTCCGCG CCGAATTCGT TATAGACTTCCTGCGGCGCG ACGACGTTGC 951 CGATGGATTT CGACATTTTG CGGCCGTTTT GGTCAACCACGAAACCGTGG 1001 GTCAGCAGCT GTTTATACGG TGCGCGTCCC ATGGATGAThis corresponds to the amino acid sequence <SEQ ID 876; ORF 236.ng>:

g236.pep 1 MARFAFSADI LRTAFADGFI TCNRAHIAGV MPAAFAFFAV AGFGGNGKFI 51TDFHFCFRHQ QGKAQFFAQS IQIAGHFFRR GNFGFRLQGR TDSFVGAQRL 101 DSGGYCFARFADCRPFFHQF GFGFFVDGRE LVPSMEEDAV FFAAADDVPR 151 FFAGEAQNRC NQENQAARDVVQGGLRAAAG AAVGFGGVEA VFQDVEVERA 201 QVFRAERNNV FHGEVEGIAR IVTACQTLLQPPRQYQGVAV DFHHIRLLHG 251 IFNRIKVAQI GKQEAQGIAD AAVAFGNAFE DFFGNRQFAAVIGGCRPQAQ 301 DVRAEFVIDF LRRDDVADGF RHFAAVLVNH ETVGQQLFIR CASHG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 877>:

m236.seq (partial) 1 ..TTGCACGGAC GAACCGACGG TTTTGTCGGC GCGCAAAGGCTCGATGGCGG 51   CGGTTACCGC TTCGCGGGCT TCGCGGATTG CCGTCCATTT TTTCACCAGT101   TCGGCTTCGG TTTTTTCGTT GATGGTCGGG AACTCGTGCC AAGTATGGAA 151  GAGGACGCTG TCkTCTTCGC CGCCGCCGwT GAyGTCCCAC GCTTCTTCGC 201  CGGTGAAGCA CAAAATCGGT GCAATCAAGA GAACCAAACT GCGTGTGATG 251  TGATACAGGG CAGTTTGTGC GCTGCGGCGT GCATGGCTGT CTGCTTTGGT 301  GGTGTAGAGG CGGTCTTTCA GGATGTCGAG GTAGAACGCA CCCAAGTCTT 351  CCGAGCAGAA AGAAACArTG TCTTTTACGG CAAAGTGGaA kGCATAACGC 401  GGATAGTAAT CGCCTGCCAG ACACTCTTGC AGCTGACGTG CCAATACCAC 451  GGCGTAGCGG TCGATTTCCA CCATATCCGC CTGTTGCACG GCATCTTCAA 501  TCGGATTAAA GTCGCTCAAG TTGGCAAACA AAAAGCTCAA GGTATTGCGG 551  ATACGGCGGT AgCTTTCGGT TACGCGTTTG AGGATTTCTT TGGAAATCGC 601  CAATTCGCCG CTGTAATCGG TAGATGCCGC CCACAGGCGC AGGATGTCTG 651  CGCCGAATTC GTTATAAACC TCTTGCGGTG CAACGACGTT GCCGATGGAT 701  TTCGACATTT TTTTGCCTTC GCCGTCGACA ACGAAACCAT GGGTCAGCAG 751  CTGTTTATAC GGCGCGCGAC CCATTGAThis corresponds to the amino acid sequence <SEQ ID 878; ORF 236>:

m236.pep (partial) 1 ..LHGRTDGFVG AQRLDGGGYR FAGFADCRPF FHQFGFGFFVDGRELVPSME 51   EDAVXFAAAX DVPRFFAGEA QNRCNQENQT ACDVIQGSLC AAACMAVCFG101   GVEAVFQDVE VERTQVFRAE RNXVFYGKVE XITRIVIACQ TLLQLTCQYH 151  GVAVDFHHIR LLHGIFNRIK VAQVGKQKAQ GIADTAVAFG YAFEDFFGNR 201  QFAAVIGRCR PQAQDVCAEF VINLLRCNDV ADGFRHFFAF AVDNETMGQQ 251   LFIRRATH*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 236 shows 82.9% identity over a 258 aa overlap with a predicted ORF(ORF 236.ng) from N. gonorrhoeae:

m236/g236                                       10        20        30m236.pep                               LHGRTDGFVGAQRLDGGGYRFAGFADCRPF                              |:||||:||||||||:||| || ||||||| g236FRHQQGKAQFFAQSIQIAGHFFRRGNFGFRLQGRTDSFVGAQRLDSGGYCFARFADCRPF  60        70        80        90       100       110        40        50        60        70        80        90 m236.pepFHQFGFGFFVDGRELVPSMEEDAVXFAAAXDVPRFFAGEAQNRCNQENQTACDVIQGSLC|||||||||||||||||||||||| |||| |||||||||||||||||||:| ||:||:| g236FHQFGFGFFVDGRELVPSMEEDAVFFAAADDVPRFFAGEAQNRCNQENQAARDVVQGGLR 120       130       140       150       160       170       100       110       120       130       140       150 m236.pepAAACMAVCFGGVEAVFQDVEVERTQVFRAERNXVFYGKVEXITRIVIACQTLLQLTCQYH|||  || |||||||||||||||:|||||||| ||:|:|| |:||| |||||||   ||: g236AAAGAAVGFGGVEAVFQDVEVERAQVFRAERNNVFHGEVEGIARIVTACQTLLQPPRQYQ 180       190       200       210       220       230       160       170       180       190       200       210 m236.pepGVAVDFHHIRLLHGIFNRIKVAQVGKQKAQGIADTAVAFGYAFEDFFGNRQFAAVIGRCR|||||||||||||||||||||||:|||:||||||:||||| |||||||||||||||| || g236GVAVDFHHIRLLHGIFNRIKVAQIGKQEAQGIADAAVAFGNAFEDFFGNRQFAAVIGGCR 240       250       260       270       280       290       220       230       240       250       259 m236.pepPQAQDVCAEFVINLLRCNDVADGFRHFFAFAVDNETMGQQLFIRRATHX|||||| |||||::|| :||||||||| |  |::||:||||||| |:| g236PQAQDVRAEFVIDFLRRDDVADGFRHFAAVLVNHETVGQQLFIRCASHG 300       310       320       330       340The following partial DNA sequence was identified in N. meningitidis<SEQ ID 879>:

a236.seq 1 ATGGCGCGTT TCGCCTTCTC CGCCGACATT CTCTGCACAG CGTTTGCAGA 51CGGTTTCATG GCCTGCAACC GCGCCCACAT CGCGGGTGTA GTGCCAGCAG 101 CGTTCGCATTTTTCACCATC ACTGGCTTTA GCGGCAACGG CAAGTTCGCT 151 GCCTACTTTC ACTTCTGCTTTAGACACCAG CAAAGCAAAG CGCAATTCTT 201 CGCCCAAAGC ATTCAGATAG CCGGCCATTTCTTCCGGCGC GGTAATTTCG 251 GCTTCGGCTT GCAAGGACGA ACCGACGGTT TTGTCGGCGCGCAAAGGCTC 301 GATGGCGGCG GTTACCGCTT CGCGGGCTTC GCGGATTGCC GTCCATTTTT351 TCACCAGTTC GGCTTCGGCT TTTTCGTTGA TGGTCGGGAA CTCGTGCCAA 401GTATGGAAAA GCACGCTGTC TTCTGCGCCG CCGCCGATGA TGTCCCACGC 451 TTCTTCGCCGGTGAAGCACA AAATCGGTGC AATCAAGAGA ACCAGGCTGC 501 GCGTGATGTG GTACAGGGCGGTTTGCGCGC TGCGGCGGGC GCGGCTGTCG 551 GCTTTGGTGG TATAGAGGCG GTCTTTCAGGATATCGAGGT AGAACGCGCC 601 CAAGTCTTCC GAGCAGAAAG AAACCATTTC TTTCACGGCAAAGTGGAAGG 651 CATAACGCGG ATAAAAATCA CCGGCAACGC GTTCTTGCAG CCGCCTTGCC701 AACACCAAGG CATAGCGGTC GATTTCCACC ATATCCGCCT GTTGCACGGC 751ATCTTCAATA GGATTGAAGT CGCTCAAGTT GGCAAACAAA AAGCTCAAGG 801 TATTGCGGATACGGCGGTAG CTTTCGGTTA CGCGCTTGAG GATTTCTTTG 851 GAAATCGCCA ATTCGCCGCTGTAATCGGTG GATGCCGCCC ACAGGCGCAG 901 GATGTCCGCG CCGAACTCGT TATACACTTCTTGCGGCGCG ACGACGTTGC 951 CGATGGATTT CGACATTTTG CGCCCGTTTT GATCCACCACGAAACCATGG 1001 GTCAGCAGCT GTTTGTACGG CGCGCGACCC ATTGAThis corresponds to the amino acid sequence <SEQ ID 880; ORF 236.a>:

a236.pep 1 MARFAFSADI LCTAFADGFM ACNRAHIAGV VPAAFAFFTI TGFSGNGKFA 51AYFHFCFRHQ QSKAQFFAQS IQIAGHFFRR GNFGFGLQGR TDGFVGAQRL 101 DGGGYRFAGFADCRPFFHQF GFGFFVDGRE LVPSMEKHAV FCAAADDVPR 151 FFAGEAQNRC NQENQAARDVVQGGLRAAAG AAVGFGGIEA VFQDIEVERA 201 QVFRAERNHF FHGKVEGITR IKITGNAFLQPPCQHQGIAV DFHHIRLLHG 251 IFNRIEVAQV GKQKAQGIAD TAVAFGYALE DFFGNRQFAAVIGGCRPQAQ 301 DVRAELVIHF LRRDDVADGF RHFAPVLIHH ETMGQQLFVR RATH*m236/a236 81.0% identity in 258 aa overlap                                      10        20        30 m236.pep                              LHGRTDGFVGAQRLDGGGYRFAGFADCRPF                              |:|||||||||||||||||||||||||||| a236FRHQQSKAQFFAQSIQIAGHFFRRGNFGFGLQGRTDGFVGAQRLDGGGYRFAGFADCRPF  60        70        80        90       100       110        40        50        60        70        80        90 m236.pepFHQFGFGFFVDGRELVPSMEEDAVXFAAAXDVPRFFAGEAQNRCNQENQTACDVIQGSLC||||||||||||||||||||: ||  ||| |||||||||||||||||||:| ||:||:| a236FHQFGFGFFVDGRELVPSMEKHAVFCAAADDVPRFFAGEAQNRCNQENQAARDVVQGGLR 120       130       140       150       160       170       100       110       120       130       140       150 m236.pepAAACMAVCFGGVEAVFQDVEVERTQVFRAERNXVFYGKVEXITRIVIACQTLLQLTCQYH|||  || |||:||||||:||||:||||||||  |:|||| |||| |: :::||  ||:: a236AAAGAAVGFGGIEAVFQDIEVERAQVFRAERNHFFHGKVEGITRIKITGNAFLQPPCQHQ 180       190       200       210       220       230       160       170       180       190       200       210 m236.pepGVAVDFHHIRLLHGIFNRIKVAQVGKQKAQGIADTAVAFGYAFEDFFGNRQFAAVIGRCR|:|||||||||||||||||:||||||||||||||||||||||:|||||||||||||| || a236GIAVDFHHIRLLHGIFNRIEVAQVGKQKAQGIADTAVAFGYALEDFFGNRQFAAVIGGCR 240       250       260       270       280       290       220       230       240       250      259 m236.pepPQAQDVCAEFVINLLRCNDVADGFRHFFAFAVDNETMGQQLFIRRATHX|||||| ||:||::|| :|||||||||    : :||||||||:|||||| a236PQAQDVRAELVIHFLRRDDVADGFRHFAPVLIHHETMGQQLFVRRATHX 300       310       320       330       340The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 881>:

g237.seq 1 atgcgggaca aggttggcgg taatatcgca ctccccgccc cacgaatatt 51cgattctaac atcggcaagc tgcggaaaaa ctttaagcat atcttggcgg 101 acaagctcggtcatacgcgc aggattgtcg ataaattcgt tatccttacc 151 gccgaaaagc agcctgccgtccgcgctgag gcggtaataa tccaaaatat 201 ggcggttgtc gcatactgcc atattgttgcggataagccc ttttgtgcgc 251 gcgcccaagg gttcggtggc aataataaag gtgctgacggcaatcgcctt 301 gcgttccaaa ggccggaata tcgggttcaa accgacataa gtattgacgg351 catagaccac atttttacac tcgacgctgc cttcgggcgt gtaaaccagc 401caaccgtttt gatacggttc gatgcgcgtc atcggggatt gctcgaaaat 451 ctgcgcgccggcttcggcag cggcgctggc aacacccaac gtgtaattga 501 gcggatgaag atgcccggacaagggatcga actgtgcgcc ttggtacata 551 tcgctgtcaa gctgctgttt caactcggctttatcccaaa gttgataatg 601 actcgcaccg taatgccgtt gggcgtgttc atgccactgctgcaactctt 651 cccaatgctg cggacggacg gcaaccgtgg cataaccgcg ctgccaatcg701 caatcgatgg catgtttgcg gacgcgttcg tccaccagtt cgaccgcctg 751caaagactgt tgccaaaacc attgcgcctg ctccaagccg acctgttttt 801 caatttcccccataccgcag gcgtagtcgc tgataacctg cccgccactc 851 ctgccggacg cgccgaagccgatacgtgcg gcttccaaaa cgacggcttc 901 atgtccgtgt tccgccagcg gcaatgcggtacacaaaccg ctcaaaccgc 951 cgccgataat gcaggtttcg gctttcagac ggcattggagtttcggataa 1001 acagtatgcg gattaaccga actaaaataa taagaaggca gatattcttg1051 aaaatcaggg cgaatcattg tgtttgcttt atcgggtata ttttcggacg 1101gaatgataca gactgtcggg ccatatcgtc caaacagaaa atcggttgaThis corresponds to the amino acid sequence <SEQ ID 882; ORF 237.ng>:

g237.pep 1 MRDKVGGNIA LPAPRIFDSN IGKLRKNFKH ILADKLGHTR RIVDKFVILT 51AEKQPAVRAE AVIIQNMAVV AYCHIVADKP FCARAQGFGG NNKGADGNRL 101 AFQRPEYRVQTDISIDGIDH IFTLDAAFGR VNQPTVLIRF DARHRGLLEN 151 LRAGFGSGAG NTQRVIERMKMPGQGIELCA LVHIAVKLLF QLGFIPKLIM 201 TRTVMPLGVF MPLLQLFPML RTDGNRGITALPIAIDGMFA DAFVHQFDRL 251 QRLLPKPLRL LQADLFFNFP HTAGVVADNL PATPAGRAEADTCGFQNDGF 301 MSVFRQRQCG TQTAQTAADN AGFGFQTALE FRINSMRINR TKIIRRQIFL351 KIRANHCVCF IGYIFGRNDT DCRAISSKQK IG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 883>:

m237.seq 1 ATGCGGGACA AGGTTGGCGG TAATGTCGCA CTCCCCGCCC CACGAATATT 51CGATTTTGAC ATCGGCAAGC TGCGGAAAAA CTTTAAGCAT ATCTTGGCGG 101 ACAAGCTCGGTCATaCGCTC AGGATTGTCG ATAAACTCGT TATCCTTACC 151 GCCGAAAAGC AGTCTGCCGTCCGCGCTGAG GCGGTAATAA TCCAAAATAT 201 GGCGGTTGTC GCATACTGCC ATATTGTTACGGATAAGCCC TTTTGCGCGC 251 GCCCCCAAGG GTTCGGTCGC AATAATAAAG GTGCTGACAGCAATCGCCTT 301 GCGTTCCAAA GGCCGGAATA TCGGGTTCAA ACCTGCATAA GTATTGACAG351 CATAGACCAC ATTTTTGCAC TCGACGCTGC CTTCGGGCGT GTAAACCAGC 401CAACCGTTTT GATGCGGTTC GATGCACGTC ATCGGGGATT GCTCGAAAAT 451 CTGCGCACCGGCTTCGGCAG CGGCACGAGC GATGCCCAAA GTGTAAGTGA 501 GCGGATGCAG GTGTCCGGATAAGGGGTCGA ATTGTGCCCC TTGGTACATA 551 TCGCTGTCAA GCTGCTGTTT CAACTCGGCTTTATCCCAAA GTTGATAATG 601 ACTCGCACCG TAATGCCGTT GGGCGTGTTC ATGCCACTGCTGCAACTCTT 651 CCCAATGCTG CGGACGGACG GCAACCGTGG CATAACCGCG CTGCCAATCA701 CAATCGACGG CATGTTTGCG GACGCGTTCG TCCACCAGTT CGACCGCCTG 751CAAAGACTGT TGCCAAAACC ATTGCGCCTG CTCCAAGCCG ACCTGTTTTT 801 CAATTTCCCCCATACCGCAG nCGTAATCGC TGATAACCTG CCCGCCACTC 851 CGTCCCGACG CGCCGAAACCGATACGCGCG GCTTCCAACA CAACCGTTTC 901 ATGTCCCTGC TCCGCCAAGG GCAATGCAGTGCACAAACCA CCCAATCCGC 951 CGCCGATGAT ACAGGTATCG GTTTTCAGAC GGCATTGAAGTTtCGGATAA 1001 ACAGTATGAG GATTAACCGA ACTGAAATAA TAAGAAGGCA GATATTCTTG1051 AAAATCAGGG CGAATCATTG TGTTTGCTTT ATCAGGTGTA TTTTCGGACG 1101GAATGATACA GGCTGTCGGG CCATATCGTC CAwACAGAAA ATCGGTTGAThis corresponds to the amino acid sequence <SEQ ID 884; ORF 237>:

m237.pep 1 MRDKVGGNVA LPAPRIFDFD IGKLRKNFKH ILADKLGHTL RIVDKLVILT 51AEKQSAVRAE AVIIQNMAVV AYCHIVTDKP FCARPQGFGR NNKGADSNRL 101 AFQRPEYRVQTCISIDSIDH IFALDAAFGR VNQPTVLMRF DARHRGLLEN 151 LRTGFGSGTS DAQSVSERMQVSGXGVELCP LVHIAVKLLF QLGFIPKLIM 201 TRTVMPLGVF MPLLQLFPML RTDGNRGITALPITIDGMFA DAFVHQFDRL 251 QRLLPKPLRL LQADLFFNFP HTAXVIADNL PATPSRRAETDTRGFQHNRF 301 MSLLRQGQCS AQTTQSAADD TGIGFQTALK FRINSMRINR TEIIRRQIFL351 KIRANHCVCF IRCIFGRNDT GCRAISSXQK IG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 237 shows 86.1% identity over a 382 aa overlap with a predicted ORF(ORF 237.ng) from N. gonorrhoeae:

m237/g237         10        20        30        40        50        60m237.pep MRDKVGGNVALPAPRIFDFDIGKLRKNFKHILADKLGHTLRIVDKLVILTAEKQSAVRAE||||||||:||||||||| :||||||||||||||||||| |||||:|||||||| ||||| g237MRDKVGGNIALPAPRIFDSNIGKLRKNFKHILADKLGHTRRIVDKFVILTAEKQPAVRAE        10        20        30        40        50        60        70        80        90       100       110       120 m237.pepAVIIQNMAVVAYCHIVTDKPFCARPQGFGRNNKGADSNRLAFQRPEYRVQTCISIDSIDH||||||||||||||||:||||||| |||| ||||||:|||||||||||||| ||||:||| g237AVIIQNMAVVAYCHIVADKPFCARAQGFGGNNKGADGNRLAFQRPEYRVQTDISIDGIDH        70        80        90       100       110       120       130       140       150       160       170       180 m237.pepIFALDAAFGRVNQPTVLMRFDARHRGLLENLRTGFGSGTSDAQSVSERMQVSGXGVELCP||:||||||||||||||:||||||||||||||:|||||::::| | |||:: | |:||| g237IFTLDAAFGRVNQPTVLIRFDARHRGLLENLRAGFGSGAGNTQRVIERMKMPGQGIELCA       130       140       150       160       170       180       190       200       210       220       230       240 m237.pepLVHIAVKLLFQLGFIPKLIMTRTVMPLGVFMPLLQLFPMLRTDGNRGITALPITIDGMFA|||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||| g237LVHIAVKLLFQLGFIPKLIMTRTVMPLGVFMPLLQLFPMLRTDGNRGITALPIAIDGMFA       190       200       210       220       230       240       250       260       270       280       290       300 m237.pepDAFVHQFDRLQRLLPKPLRLLQADLFFNFPHTAXVIADNLPATPSRRAETDTRGFQHNRF||||||||||||||||||||||||||||||||| |:||||||||: |||:|| |||:: | g237DAFVHQFDRLQRLLPKPLRLLQADLFFNFPHTAGVVADNLPATPAGRAEADTCGFQNDGF       250       260       270       280       290       300       310       320       330       340       350       360 m237.pepMSLLRQGQCSAQTTQSAADDTGIGFQTALKFRINSMRINRTEIIRRQIFLKIRANHCVCF||::|| ||::||:|:|||::|:||||||:|||||||||||:|||||||||||||||||| g237MSVFRQRQCGTQTAQTAADNAGFGFQTALEFRINSMRINRIKIIRRQIFLKIRANHCVCF       310       320       330       340       350       360       370       380 m237.pep IRCIFGRNDTGCRAISSXQKIGX|  ||||||| |||||| ||||| g237 IGYIFGRNDTDCRAISSKQKIGX       370       380The following partial DNA sequence was identified in N. meningitidis<SEQ ID 885>:

a237.seq 1 ATGCGGGACA AGGTTGGCGG TAATGTCGCA CTCCCCGCCC CACGAATATT 51CGATTTTGAC ATCGGCAAGC TGCGGAAAAA CTTTAAGCAT ATCTTGGCGG 101 ACAAGCTCGGTCATACGCGC GGGATTGTCG ATAAACTCGT TATCCTTACC 151 GCCGAAAAGC AGTCTGCCGTCCGCGCTGAG GCGGTAATAA TCCAAAATAT 201 GACGGTTGTC GCATACTGCC ATATTGTTGCGGATAAGCCC TTTTGCACGC 251 GCGCCCAAGG GTTCTGTGGC AATAATAAAG GTGCTGACAGCAATCGCCTT 301 GCGCTCCAAA GGCTTGAATA TCGGATTCAA ACCGGCATAA GTATTGACGG351 CGTACACCAG ATTTTTGCAT TCGACGCTGC CTTCGGGGGT GTAAACCAGC 401CAACCGTTTT GATAAGGTTC AATGCGTATC ATGGGAGAAT GCTCAAAAAT 451 CTTCGTACCAGCTTCGGCAG CGGCGCGGGC GATGCCCAAC GTGTAATTGA 501 GCGGATGGAG ATGCCCGGACAAGGGATCGA ACTGTGCGCC TTGGTACATA 551 TCGCTGTCAA GCTGCTGCTT CAGTTCAGTGTTATCCCAGA GTTGATAATG 601 AGTTGCACCG TAATATTTTT GGGCGTGCTC ATGCCATTGTTGCAATTCTT 651 CCCAATGCTG CGAACGGATG GCAACCGTGG CATAACCGCG CTGCCAATCG701 CAATCAATGG CATGTTTGCG GACGCGTTCG TCCACCAGTT CGACCGCCTG 751CAAAGACTGT TGCCAAAACC ATTGCGCTTG CTCCAAACCG ACCTGTTTTT 801 CAATTTCCTCCATACCGCAG GCGTAATCGC TGATAACCTG CCCGCCACTC 851 CGTCCCGACG CGCCGAAACCGATACGCGCG GCTTCCAACA CAACCGTTTC 901 ATGTCCCTGC TCCGCCAAGG GCAATGCAGTGCACAAACCA CTCAATCCGC 951 CGCCGATGAT ACAGGTATCG GTTTTCAGAC GGCATTGAAGTTTCGGATAA 1001 ACAGTATGAG GATTAACCGA ACTGAAATAA TAAGAAGGCA GATATTCTTG1051 AAAATCAGGG CGAATCATTG TGTTTGCTTT ATCGGGTATA TTTTCGGACG 1101GAATGATACA GGCTGTCGAG CCATATCGTC CAAACAGAAA ATCGGTTGAThis corresponds to the amino acid sequence <SEQ ID 886; ORF 237.a>:

a237.pep 1 MRDKVGGNVA LPAPRIFDFD IGKLRKNFKH ILADKLGHTR GIVDKLVILT 51AEKQSAVRAE AVIIQNMTVV AYCHIVADKP FCTRAQGFCG NNKGADSNRL 101 ALQRLEYRIQTGISIDGVHQ IFAFDAAFGG VNQPTVLIRF NAYHGRMLKN 151 LRTSFGSGAG DAQRVIERMEMPGQGIELCA LVHIAVKLLL QFSVIPELIM 201 SCTVIFLGVL MPLLQFFPML RTDGNRGITALPIAINGMFA DAFVHQFDRL 251 QRLLPKPLRL LQTDLFFNFL HTAGVIADNL PATPSRRAETDTRGFQHNRF 301 MSLLRQGQCS AQTTQSAADD TGIGFQTALK FRINSMRINR TEIIRRQIFL351 KIRANHCVCF IGYIFGRNDT GCRAISSKQK IG* m237/a237 85.6% identity in 382aa overlap         10        20        30        40        50        60m237.pep MRDKVGGNVALPAPRIFDFDIGKLRKNFKHILADKLGHTLRIVDKLVILTAEKQSAVRAE|||||||||||||||||||||||||||||||||||||||  ||||||||||||||||||| a237MRDKVGGNVALPAPRIFDFDIGKLRKNFKHILADKLGHTRGIVDKLVILTAEKQSAVRAE        10        20        30        40        50        60        70        80        90       100       110       120 m237.pepAVIIQNMAVVAYCHIVTDKPFCARPQGFGRNNKGADSNRLAFQRPEYRVQTCISIDSIDH|||||||:||||||||:|||||:| |||  |||||||||||:|| |||:|| ||||:: : a237AVIIQNMTVVAYCHIVADKPFCTRAQGFCGNNKGADSNRLALQRLEYRIQTGISIDGVHQ        70        80        90       100       110       120       130       140       150       160       170       180 m237.pepIFALDAAFGRVNQPTVLMRFDARHRGLLENLRTGFGSGTSDAQSVSERMQVSGXGVELCP|||:||||| |||||||:||:|   :|:||||:||||::||| | |||:: | |:||| a237IFAFDAAFGGVNQPTVLIRFNAYHGRMLKNLRTSFGSGAGDAQRVIERMEMPGQGIELCA       130       140       150       160       170       180       190       200       210       220       230       240 m237.pepLVHIAVKLLFQLGFIPKLIMTRTVMPLGVFMPLLQLFPMLRTDGNRGITALPITIDGMFA|||||||||:|:: ||:|||: ||: |||:|||||:|||||||||||||||||:|:|||| a237LVHIAVKLLLQFSVIPELIMSCTVIFLGVLMPLLQFFPMLRTDGNRGITALPIAINGMFA       190       200       210       220       230       240       250       260       270       280       290       300 m237.pepDAFVHQFDRLQRLLPKPLRLLQADLFFNFPHTAXVIADNLPATPSRRAETDTRGFQHNRF||||||||||||||||||||||:|||||| ||| |||||||||||||||||||||||||| a237DAFVHQFDRLQRLLPKPLRLLQTDLFFNFLHTAGVIADNLPATPSRRAETDTRGFQHNRF       250       260       270       280       290       300       310       320       330       340       350       360 m237.pepMSLLRQGQCSAQTTQSAADDTGIGFQTALKFRINSMRINRTEIIRRQIFLKIRANHCVCF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a237MSLLRQGQCSAQTTQSAADDIGIGFQTALKFRINSMRINRTEIIRRQIFLKIRANHCVCF       310       320       330       340       350       360       370       380 m237.pep IRCIFGRNDTGCRAISSXQKIGX|  |||||||||||||| ||||| a237 IGYIFGRNDTGCRAISSKQKIGX       370       380The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 887>:

g238.seq 1 atgaatttgc ctattcaaaa attcatgatg ctgttggcag cggcaatatc 51gatgctgcat atccccatta gtcatgcgaa cggtttggat gcccgtttgc 101 gcgatgatatgcaggcaaaa cactacgaac cgggtggcaa ataccatctg 151 tttggtaatg ctcgcggcagtgttaaaaat cgggtttgcg ccgtccaaac 201 atttgatgca actgcggtcg gccccatactgcctattaca cacgaacgga 251 caggatttga aggtgttatc ggctatgaaa cccatttttcaggacacgga 301 cacgaagtac acagtccgtt cgataatcat gattcaaaaa gcacttctga351 tttcagcggc ggcgtagacg gcggttttac cgtttaccaa cttcatcgga 401cagggtcgga aatacatccc gcagacggat atgacgggcc tcaaggcggc 451 ggttatccggaaccacaagg ggcaagggat atatacagct accatatcaa 501 aggaacttca accaaaacaaagataaacac tgttccgcaa gccccttttt 551 cagaccgctg gctaaaagaa aatgccggtgccgcttccgg ttttctcagc 601 cgtgcggatg aagcaggaaa actgatatgg gaaaacgaccccgataaaaa 651 ttggcgggct aaccgtatgg atgatattcg cggcatcgtc caaggtgcgg701 ttaatccttt tttaacgggt tttcaagggg tagggattgg ggcaattaca 751gacagtgcgg taagcccggt cacagataca gccgctcagc agactctaca 801 aggtattaatgatttaggaa atttaagtcc ggaagcacaa cttgccgccg 851 cgagcctatt acaggacagtgcctttgcgg taaaagacgg catcaattcc 901 gccagacaat gggctgatgc ccatccgaatataacagcaa cagcccaaac 951 tgcccttgcc gtagcagagg ccgcaggtac ggtttggcgcggtaaaaaag 1001 tagaacttaa cccgaccaaa tgggattggg ttaaaaatac cggctataaa1051 aaacctgctg cccgccatat gcagactgta gatggggaga tggcaggggg 1101gaatagaccg cctaaatcta taacgtcgga aggaaaagct aatgctgcaa 1151 cctatcctaagttggttaat cagctaaatg agcaaaactt aaataacatt 1201 gcggctcaag atccaagattgagtctagct attcatgagg gtaaaaaaaa 1251 ttttccaata ggaactgcaa cttatgaagaggcagataga ctaggtaaaa 1301 tttgggttgg tgagggtgca agacaaacta gtggaggcggatggttaagt 1351 agagatggca ctcgacaata tcggccacca acagaaaaaa aatcacaatt1401 tgcaactaca ggtattcaag caaattttga aacttatact attgattcaa 1451atgaaaaaag aaataaaatt aaaaatggac atttaaatat taggtaaThis corresponds to the amino acid sequence <SEQ ID 888; ORF 238.ng>:

g238.pep 1 MNLPIQKFMM LLAAAISMLH IPISHANGLD ARLRDDMQAK HYEPGGKYHL 51FGNARGSVKN RVCAVQTFDA TAVGPILPIT HERTGFEGVI GYETHFSGHG 101 HEVHSPFDNHDSKSTSDFSG GVDGGFTVYQ LHRTGSEIHP ADGYDGPQGG 151 GYPEPQGARD IYSYHIKGTSTKTKINTVPQ APFSDRWLKE NAGAASGFLS 201 RADEAGKLIW ENDPDKNWRA NRMDDIRGIVQGAVNPFLTG FQGVGIGAIT 251 DSAVSPVTDT AAQQTLQGIN DLGNLSPEAQ LAAASLLQDSAFAVKDGINS 301 ARQWADAHPN ITATAQTALA VAEAAGTVWR GKKVELNPTK WDWVKNTGYK351 KPAARHMQTV DGEMAGGNRP PKSITSEGKA NAATYPKLVN QLNEQNLNNI 401AAQDPRLSLA IHEGKKNFPI GTATYEEADR LGKIWVGEGA RQTSGGGWLS 451 RDGTRQYRPPTEKKSQFATT GIQANFETYT IDSNEKRNKI KNGHLNIR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 889>:

m238.seq 1 ATGAATTTGC CTATTCAAAA ATTCATGATG CTGTTTGCAG CAGCAATATC 51GTTGCTGCAA ATCCCCATTA GTCATGCGAA CGGTTTGGAT GCCCGTTTGC 101 GCGATGATATGCAGGCAAAA CAcTACGAAC CGGGTGGTAA ATACCATCTG 151 TTTGGTAATG CTCGCGGCAGTGTTAAAAAG CGGGTTTACG CCGTCCAGAC 201 ATTTGATGCA ACTGCGGTCA GTCCTGTACTGCCTATTACA CACGAACGGA 251 CAGGGTTTGA AGGTGTTATC GGTTATGAAA CCCATTTTTCAGGGCACGGA 301 CATGAAGTAC ACAGTCCGTT CGATCATCAT GATTCAAAAA GCACTTCTGA351 TTTCAGCGGC GGTGTAGACG GCGGTTTTAC TGTTTACCAA CTTCATCGAA 401CAGGGTCGGA AATCCATCCG GAGGATGGAT ATGACGGGCC GCAAGGCAGC 451 GATTATCCGCCCCCCGGAGG AGCAAGGGAT ATATACAGCT ATTATGTCAA 501 AGGAACTTCA ACAAAAACAAAGACTAATAT TGTCCCTCAA GCCCCATTTT 551 CAGACCGTTG GCTAAAAGAA AATGCCGGTGCCGCCTCTGG TTTTTTCAGC 601 CGTGCGGATG AAGCAGGAAA ACTGATATGG GAAAGCGACCCCAATAAAAA 651 TTGGTGGGCT AACCGTATGG ATGATGTTCG CGGCATCGTC CAAGGTGCGG701 TTAATCCTTT TTTAATGGGT TTTCAAGGAG TAGGGATTGG GGCAATTACA 751GACAGTGCAG TAAGCCCGGT CACAGATACA GCCGCGCAGC AGACTCTACA 801 AGGTATTAATGATTTAGGAA AATTAAGTCC GGAAGCACAA CTTGCTGCCG 851 CGAGCCTATT ACAGGACAGTGCTTTTGCGG TAAAAGACGG TATCAACTCT 901 GCCAAACAAT GGGCTGATGC CCATCCAAATATAACAGCTA CTGCCCAAAC 951 TGCCCTTTCC GCAGCAGAGG CCGCAGGTAC GGTTTGGAGAGGTAAAAAAG 1001 TAGAACTTAA CCCGACTAAA TGGGATTGGG TTAAAAATAC CGGTTATAAA1051 AAACCTGCTG CCCGCCATAT GCAGACTTTA GATGGGGAGA TGGCAGGTGG 1101GAATAAACCT ATTAAATCTT TACCAAACAG TGCCGCTGAA AAAAGAAAAC 1151 AAAATTTTGAGAAGTTTAAT AGTAACTGGA GTTCAGCAAG TTTTGATTCA 1201 GTGCACAAAA CACTAACTCCCAATGCACCT GGTATTTTAA GTCCTGATAA 1251 AGTTAAAACT CGATACACTA GTTTAGATGGAAAAATTACA ATTATAAAAG 1301 ATAACGAAAA CAACTATTTT AGAATCCATG ATAATTCACGAAAACAGTAT 1351 CTTGATTCAA ATGGTAATGC TGTGAAAACC GGTAATTTAC AAGGTAAGCA1401 AGCAAAAGAT TATTTACAAC AACAAACTCA TATCAGGAAC TTAGACAAAT 1451 GAThis corresponds to the amino acid sequence <SEQ ID 890; ORF 238>:

m238.pep 1 MNLPIQKFMM LFAAAISLLQ IPISHANGLD ARLRDDMQAK HYEPGGKYHL 51FGNARGSVKK RVYAVQTFDA TAVSPVLPIT HERTGFEGVI GYETHFSGHG 101 HEVHSPFDHHDSKSTSDFSG GVDGGFTVYQ LHRTGSEIHP EDGYDGPQGS 151 DYPPPGGARD IYSYYVKGTSTKTKTNIVPQ APFSDRWLKE NAGAASGFFS 201 RADEAGKLIW ESDPNKNWWA NRMDDVRGIVQGAVNPFLMG FQGVGIGAIT 251 DSAVSPVTDT AAQQTLQGIN DLGKLSPEAQ LAAASLLQDSAFAVKDGINS 301 AKQWADAHPN ITATAQTALS AAEAAGTVWR GKKVELNPTK WDWVKNTGYK351 KPAARHMQTL DGEMAGGNKP IKSLPNSAAE KRKQNFEKFN SNWSSASFDS 401VHKTLTPNAP GILSPDKVKT RYTSLDGKIT IIKDNENNYF RIHDNSRKQY 451 LDSNGNAVKTGNLQGKQAKD YLQQQTHIRN LDK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 238 shows 86.0% identity over a 401 aa overlap with a predicted ORF(ORF 238.ng) from N. gonorrhoeae:

m238/g238           10        20        30        40        50        60m238.pep   MNLPIQKFMMLFAAAISLLQIPISHANGLDARLRDDMQAKHYEPGGKYHLFGNARGSVKK  |||||||||||:|||||:|:|||||||||||||||||||||||||||||||||||||||: g238  MNLPIQKFMMLLAAAISMLHIPISHANGLDARLRDDMQAKHYEPGGKYHLFGNARGSVKN          10        20        30        40        50        60          70        80        90       100       110       120 m238.pep  RVYAVQTFDATAVSPVLPITHERTGFEGVIGYETHFSGHGHEVHSPFDHHDSKSTSDFSG  || ||||||||||:|:||||||||||||||||||||||||||||||||:||||||||||| g238  RVCAVQTFDATAVGPILPITHERTGFEGVIGYETHFSGHGHEVHSPFDNHDSKSTSDFSG          70        80        90       100       110       120         130       140       150       160       170       180 m238.pep  GVDGGFTVYQLHRTGSEIHPEDGYDGPQGSDYPPPGGARDIYSYYVKGTSTKTKTNIVPQ  |||||||||||||||||||| ||||||||: || | ||||||||::|||||||| | ||| g238  GVDGGFTVYQLHRTGSEIHPADGYDGPQGGGYPEPQGARDIYSYHIKGTSTKTKINTVPQ         130       140       150       160       170       180         190       200       210       220       230       240 m238.pep  APFSDRWLKENAGAASGFFSRADEAGKLIWESDPNKNWWANRMDDVRGIVQGAVNPFLMG  ||||||||||||||||||:||||||||||||:||:||| ||||||:|||||||||||| | g238  APFSDRWLKENAGAASGFLSRADEAGKLIWENDPDKNWRANRMDDIRGIVQGAVNPFLTG         190       200       210       220       230       240         250       260       270       280       290       300 m238.pep  FQGVGIGAITDSAVSPVTDTAAQQTLQGINDLGKLSPEAQLAAASLLQDSAFAVKDGINS  |||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||| g238  FQGVGIGAITDSAVSPVTDTAAQQTLQGINDLGNLSPEAQLAAASLLQDSAFAVKDGINS         250       260       270       280       290       300         310       320       330       340       350       360 m238.pep  AKQWADAHPNITATAQTALSAAEAAGTVWRGKKVELNPTKWDWVKNTGYKKPAARHMQTL  |:|||||||||||||||||::||||||||||||||||||||||||||||||||||||||: g238  ARQWADAHPNITATAQTALAVAEAAGTVWRGKKVELNPTKWDWVKNTGYKKPAARHMQTV         310       320       330       340       350       360         370       380       390       400       410       420 m238.pep  DGEMAGGNKPIKSLPNSAAEKRKQNFEKFNSNWSSASFDSVHKTLTPNAPGILSPDKVKT  ||||||||:| ||: :| ::    :: |: :: :  ::::: g238  DGEMAGGNRPPKSI-TSEGKANAATYPKLVNQLNEQNLNNIAAQDPRLSLAIHEGKKNFP         370        380       390       400       410         430       440       450       460       470       480 m238.pep  RYTSLDGKITIIKDNENNYFRIHDNSRKQYLDSNGNAVKTGNLQGKQAKDYLQQQTHIRN g238  IGTATYEEADRLGKIWVGEGARQTSGGGWLSRDGTRQYRPPTEKKSQFATTGIQANFETY420       430       440       450       460       470The following partial DNA sequence was identified in N. meningitidis<SEQ ID 891>:

a238.seq (partial) 1 ATGAATTTGC CTATTCAAAA ATTCATGATG CTGTTTGCAGCAGCAATATC 51 GTTGCTGCAA ATCCCCATTA GTCATGCGAA CGGTTTGGAT GCCCGTTTGC 101GCGATGATAT GCAGGCAAAA CACTACGAAC CGGGTGGTAA ATACCATCTG 151 TTTGGTAATGCTCGCGGCAG TGTTAAAAAT CGGGTTTACG CCGTCCAAAC 201 ATTTGATGCA ACTGCGGTCGGCCCCATACT GCCTATTACA CACGAACGGA 251 CAGGATTTGA AGGCATTATC GGTTATGAAACCCATTTTTC AGGACATGGA 301 CATGAAGTAC ACAGTCCGTT CGATAATCAT GATTCAAAAAGCACTTCTGA 351 TTTCAGCGGC GGCGTAGACG GTGGTTTTAC CGTTTACCAA CTTCATCGGA401 CAGGGTCGGA AATCCATCCG GAGGATGGAT ATGACGGGCC GCAAGGCAGC 451GATTATCCGC CCCCCGGAGG AGCAAGGGAT ATATACAGCT ACTATGTCAA 501 AGGAACTTCAACAAAAACAA AGAGTAATAT TGTTCCCCGA GCCCCATTTT 551 CAGACCGCTG GCTAAAAGAAAATGCCGGTG CCGCCTCTGG TTTTTTCAGC 601 CGTGCTGATG AAGCAGGAAA ACTGATATGGGAAAGCGACC CCAATAAAAA 651 TTGGTGGGCT AACCGTATGG ATGATATTCG CGGCATCGTCCAAGGTGCGG 701 TTAATCCTTT TTTAATGGGT TTTCAAGGAG TAGGGATTGG GGCAATTACA751 GACAGTGCAG TAAGCCCGGT CACAGATACA GCCGCGCAGC AGACTCTACA 801AGGTATTAAT CATTTAGGAA ATTTAAGTCC CGAAGCACAA CTTGCGGCTG 851 CAACCGCATTACAAGACAGT GCTTTTGCGG TAAAAGACGG TATCAATTCC 901 GCCAGACAAT GGGCTGATGCCCATCCGAAT ATAACTGCAA CAGCCCAAAC 951 TGCCCTTGCC GTAGCAGAGG CCGCAACTACGGTTTGGGGC GGTAAAAAAG 1001 TAGAACTTAA CCCGACCAAA TGGGATTGGG TTAAAAATACCGGCTATAAA 1051 ACACCTGCTG TTCGCACCAT GCATACTTTG GATGGGGAAA TGGCCGGTGG1101 GAATAGACCG CCTAAATCTA TAACGTCCAA CAGCAAAGCA GATGCTTCCA 1151 CACAAThis corresponds to the amino acid sequence <SEQ ID 892; ORF 238.a>:

a238.pep (partial) 1 MNLPIQKFMM LFAAAISLLQ IPISHANGLD ARLRDDMQAKHYEPGGKYHL 51 FGNARGSVKN RVYAVQTFDA TAVGPILPIT HERTGFEGII GYETHFSGHG 101HEVHSPFDNH DSKSTSDFSG GVDGGFTVYQ LHRTGSEIHP EDGYDGPQGS 151 DYPPPGGARDIYSYYVKGTS TKTKSNIVPR APFSDRWLKE NAGAASGFFS 201 RADEAGKLIW ESDPNKNWWANRMDDIRGIV QGAVNPFLMG FQGVGIGAIT 251 DSAVSPVTDT AAQQTLQGIN HLGNLSPEAQLAAATALQDS AFAVKDGINS 301 ARQWADAHPN ITATAQTALA VAEAATTVWG GKKVELNPTKWDWVKNTGYK 351 TPAVRTMHTL DGEMAGGNRP PKSITSNSKA DASTQ m238/a238 91.9%identity in 385 aa overlap        10        20        30        40        50        60 m238.pepMNLPIQKFMMLFAAAISLLQIPISHANGLDARLRDDMQAKHYEPGGKYHLFGNARGSVKK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: a238MNLPIQKFMMLFAAAISLLQIPISHANGLDARLRDDMQAKHYEPGGKYHLFGNARGSVKN        10        20        30        40        50        60        70        80        90       100       110       120 m238.pepRVYAVQTFDATAVSPVLPITHERTGFEGVIGYETHFSGHGHEVHSPFDHHDSKSTSDFSG|||||||||||||:|:||||||||||||:|||||||||||||||||||:||||||||||| a238RVYAVQTFDATAVGPILPITHERTGFEGIIGYETHFSGHGHEVHSPFDNHDSKSTSDFSG        70        80        90       100       110       120       130       140       150       160       170       180 m238.pepGVDGGFTVYQLHRTGSEIHPEDGYDGPQGSDYPPPGGARDIYSYYVKGTSTKTKTNIVPQ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||: a238GVDGGFTVYQLHRTGSEIHPEDGYDGPQGSDYPPPGGARDIYSYYVKGTSTKTKSNIVPR       130       140       150       160       170       180       190       200       210       220       230       240 m238.pepAPFSDRWLKENAGAASGFFSRADEAGKLIWESDPNKNWWANRMDDVRGIVQGAVNPFLMG|||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||| a238APFSDRWLKENAGAASGFFSRADEAGKLIWESDPNKNWWANRMDDIRGIVQGAVNPFLMG       190       200       210       220       230       240       250       260       270       280       290       300 m238.pepFQGVGIGAITDSAVSPVTDTAAQQTLQGINDLGKLSPEAQLAAASLLQDSAFAVKDGINS|||||||||||||||||||||||||||||| |:||||||||||: |||||||||||||| a238FQGVGIGAITDSAVSPVTDTAAQQTLQGINHLGNLSPEAQLAAATALQDSAFAVKDGINS       250       260       270       280       290       300       310       320       330       340       350       360 m238.pepAKQWADAHPNITATAQTALSAAEAAGTVWRGKKVELNPTKWDWVKNTGYKKPAARHMQTL|:|||||||||||||||||::|||| ||| |||||||||| |||||||||| ||:| |:|| a238ARQWADAHPNITATAQTALAVAEAATTVWGGKKVELNPTKWDWVKNTGYKTPAVRTMHTL       310       320       330       340       350       360       370        380       390       400       410      419 m238.pepDGEMAGGNKPIKSLP-NSAAEKRKQNFEKFNSNWSSASFDSVHKTLTPNAPGILSPDKVK||||||||:| ||:  || |:   | a238 DGEMAGGNRPPKSITSNSKADASTQThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 893>:

g239.seq 1 atgttccacc ataaaggtat tgcccgaaac cggcggatgg aggttttgtt 51tttctgccgc cgccctgatc gcttcgtgat tcgccaaacg cgcctgttgc 101 agcctcatttgcgcataatc ctgctccaag gcgatttcct gttttttcgc 151 cttgtccaaa gctgtgaagttgagcctgta ctggttttgc tgcatcacaa 201 cggaaaaagc ggaaacgcac accgcaagcagcagaaagaa attcgatttg 251 ttcattgccg ttcagacgtt tttctctgtt attattccggtatcggaccg 301 gcagtccgct ccgccacacg caaaactgcg ctcctcgccc tcgggttggc351 ggcaatttcc gcttcacccg gctttaatgc cctgcccacg attttcaggg 401gcggatcggg caaatccgct tctctgaccg ccgcccagct cggcaggggc 451 tcgtgttgcgaatatttttt gacaaactgc ttcacaatgc ggtcttccaa 501 cgaatggaaa gcaatgaccgccaaacgccc gccctctttc agacggcaca 551 tgacctgcgg caataccgcc cctacttcttcaagctcgcg gttaataaag 601 atgcggattg cctggaaggt gcgcgtcgca ggatcctgcccccgctcgcg 651 agtacggacg ttttgtgcca cgatctgcgc cagcttgcgg gttgtatcga701 ttggactttc cgcccgttgc gcgacaatgg cgcgcacaat ctggcggcta 751aaccgctctt caccataaThis corresponds to the amino acid sequence <SEQ ID 894; ORF 239.ng>:

g239.pep 1 MFHHKGIARN RRMEVLFFCR RPDRFVIRQT RLLQPHLRII LLQGDFLFFR 51LVQSCEVEPV LVLLHHNGKS GNAHRKQQKE IRFVHCRSDV FLCYYSGIGP 101 AVRSATRKTALLALGLAAIS ASPGFNALPT IFRGGSGKSA SLTAAQLGRG 151 SCCEYFLTNC FTMRSSNEWKAMTAKRPPSF RRHMTCGNTA PTSSSSRLIK 201 MRIAWKVRVAGSCPRSRVRT FCATICASLR VVSIGLSARC ATMARTIWRL 251 NRSSP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 895>:

m239.seq 1 ATGCTCCACC ATAAAGGTmy kGCCCGAAAC CGGCkGATGG AGGTTTTGTT 51TTTCTGCCGC CGCCCTGATC GCTTCGTGGT TCGCCAAACG CGCCTGTTGC 101 AGCCTCATTTGCGCATAATC CTGCTCCAAG GCGATTTCCT GTTTTTTCGC 151 CTTATCCAAA GCTGTGAAATTGAGCCTGTA CTGGTTTTGC TGCATCACAA 201 CGGAAAAAGC GGAAACGCAC ACCGCAAGCAGCAGAAGGAA ATTCAATTTG 251 TTCATTGCCA TTCAGACGTT TTTCTCTGTG ATTGTTCCGGTATCGGACCG 301 GCAGTCCGCT CCGCCACACG CAAAACCGCA CTTCTCGCCC TCGGATTGGC351 GGCAATTTCC GCCTCACCCG GCTTTAATGC CCTGCCCACG ATTTTCAGGG 401GCAGCTCGGG CAAATCCGCT TCCCTGaCCG CCGCCCAGCG CGGCAGGGGC 451 GCGTGTTGCGAATATTTTTT GACAAACTGC TTCACAATGC GATCTTCCAA 501 CGAATGGAAA GCAATGACCGCCAAACGTCC GCCCTCTTTC AGACGACACA 551 TGACCTGCGG CAATACTGCC CCTACTTCTTCAAGCTCGCG GTTAATAAAG 601 ATGCGGACCG CCTGGAAGGT GCGCGTCGCA GGATCCTGCCCCCGCTCGCG 651 AGTACGGACG TTTTGTGCCA CGATCTGCGC CAGCTTGCGG GTTGTATCGA701 TTGGACTTTC CGCCCGTTGC GCAACAATGG CGCGCGCAAT cCGGCGGCTa 751AACCGCTCTT cACCATAAThis corresponds to the amino acid sequence <SEQ ID 896; ORF 239>:

m239.pep 1 MLHHKGXARN RXMEVLFFCR RPDRFVVRQT RLLQPHLRII LLQGDFLFFR 51LIQSCEIEPV LVLLHHNGKS GNAHRKQQKE IQFVHCHSDV FLCDCSGIGP 101 AVRSATRKTALLALGLAAIS ASPGFNALPT IFRGSSGKSA SLTAAQRGRG 151 ACCEYFLTNC FTMRSSNEWKAMTAKRPPSF RRHMTCGNTA PTSSSSRLIK 201 MRTAWKVRVAGSCPRSRVRT FCATICASLR VVSIGLSARC ATMARAIRRL 251 NRSSP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 239 shows 93.7% identity over a 255 aa overlap with a predicted ORF(ORF 239.ng) from N. gonorrhoeae:

m239/g239         10        20        30        40        50        60m239.pep MLHHKGXARNRXMEVLFFCRRPDRFVVRQTRLLQPHLRIILLQGDFLFFRLIQSCEIEPV|:|||| |||| ||||||||||||||:||||||||||||||||||||||||:||||:||| g239MFHHKGIARNRRMEVLFFCRRPDRFVIRQTRLLQPHLRIILLQGDFLFFRLVQSCEVEPV        10        20        30        40        50        60        70        80        90       100       110       120 m239.pepLVLLHHNGKSGNAHRKQQKEIQFVHCHSDVFLCDCSGIGPAVRSATRKTALLALGLAAIS|||||||||||||||||||||:||||:||||||  ||||||||||||||||||||||||| g239LVLLHHNGKSGNAHRKQQKEIRFVHCRSDVFLCYYSGIGPAVRSATRKTALLALGLAAIS        70        80        90       100       110       120       130       140       150       160       170       180 m239.pepASPGFNALPTIFRGSSGKSASLTAAQRGRGACCEYFLTNCFTMRSSNEWKAMTAKRPPSF||||||||||||||:||||||||||| |||:||||||||||||||||||||||||||||| g239ASPGFNALPTIFRGGSGKSASLTAAQLGRGSCCEYFLTNCFTMRSSNEWKAMTAKRPPSF       130       140       150       160       170       180       190       200       210       220       230       240 m239.pepRRHMTCGNTAPTSSSSRLIKMRTAWKVRVAGSCPRSRVRTFCATICASLRVVSIGLSARC|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| g239RRHMTCGNTAPTSSSSRLIKMRIAWKVRVAGSCPRSRVRTFCATICASLRVVSIGLSARC       190       200       210       220       230       240        250m239.pep ATMARAIRRLNRSSPX |||||:| |||||||| g239 ATMARTIWRLNRSSPX       250The following partial DNA sequence was identified in N. meningitidis<SEQ ID 897>:

a239.seq 1 ATGCTCCACC ATAAAGGTAT TGCCCGAAAC CGGCGGATGG AGGTTTTGTT 51TTTCTGCCGC CGCCCTGATC GCTTCGTGGT TCGCCAAACG CGCCTGTTGC 101 AGCCTCATTTGCGCATAATC CTGCTCCAAG GCGATTTCCT GTTTTTTCGC 151 CTTATCCAAA GCTGTGAAGTTGAGCCTGTA CTGGTTTTGC TGCATCACAA 201 CGGAAAAAGC GGAAACGCAC ACCGCAAGCAGCAGAAGGAA ATTCAATTTG 251 TTCATTGCCA TTCAGACGTT TTTCTCTGTG ATTGTTCCGGTATCGGACCG 301 GCAGTCCGCT CCGCCACACG CAAAACCGCA CTTCTCGCCC TCGGATTGGC351 GGCAATTTCC GCCTCACCCG GCTTTAATGC CCTGCCCGCG ATTTTCAGGG 401GCGGCTCGGG CAAATCCGCT TCCCTGACCG CCGCCCAGCG CGGCAGGGGC 451 GCGTGTTGCGAATATTTTTT GACAAACTGC TTCACAATGC GGTCTTCCAA 501 CGAATGGAAA GCAATGACCGCCAAACGTCC GCCCTCTTTC AGACGACACA 551 TGACCTGCGG CAATACTGCC CCTACTTCTTCAAGCTCGCG GTTAATAAAG 601 ATGCGGATTG CCTGGAAGGT GCGCGTCGCA GGATCCTGCCCCCGCTCGCG 651 AGTACGGACG TTTTGTGCCA CGATCTGCGC CAGCTTGCGG GTTGTATCGA701 TTGGACTTTC CGCCCGTTGC GCAACAATGG CGCGCGCAAT CTGGCGGCTA 751AACCGCTCTT CACCATAAThis corresponds to the amino acid sequence <SEQ ID 898; ORF 239.a>:

a239.pep 1 MLHHKGIARN RRMEVLFFCR RPDRFVVRQT RLLQPHLRII LLQGDFLFFR 51LIQSCEVEPV LVLLHHNGKS GNAHRKQQKE IQFVHCHSDV FLCDCSGIGP 101 AVRSATRKTALLALGLAAIS ASPGFNALPA IFRGGSGKSA SLTAAQRGRG 151 ACCEYFLTNC FTMRSSNEWKAMTAKRPPSF RRHMTCGNTA PTSSSSRLIK 201 MRIAWKVRVA GSCPRSRVRT FCATICASLRVVSIGLSARC ATMARAIWRL 251 NRSSP* m239/a239 97.3% identity in 255 aaoverlap         10        20        30        40        50        60m239.pep MLHHKGXARNRXMEVLFFCRRPDRFVVRQTRLLQPHLRIILLQGDFLFFRLIQSCEIEPV|||||| |||| ||||||||||||||||||||||||||||||||||||||||||||:||| a239MLHHKGIARNRRMEVLFFCRRPDRFVVRQTRLLQPHLRIILLQGDFLFFRLIQSCEVEPV        10        20        30        40        50        60        70        80        90       100       110       120 m239.pepLVLLHHNGKSGNAHRKQQKEIQFVHCHSDVFLCDCSGIGPAVRSATRKTALLALGLAAIS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a239LVLLHHNGKSGNAHRKQQKEIQFVHCHSDVFLCDCSGIGPAVRSATRKTALLALGLAAIS        70        80        90       100       110       120       130       140       150       160       170       180 m239.pepASPGFNALPTIFRGSSGKSASLTAAQRGRGACCEYFLTNCFTMRSSNEWKAMTAKRPPSF|||||||||:||||:||||||||||||||||||||||||||||||||||||||||||||| a239ASPGFNALPAIFRGGSGKSASLTAAQRGRGACCEYFLTNCFTMRSSNEWKAMTAKRPPSF       130       140       150       160       170       180       190       200       210       220       230       240 m239.pepRRHMTCGNTAPTSSSSRLIKMRTAWKVRVAGSCPRSRVRTFCATICASLRVVSIGLSARC|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| a239RRHMTCGNTAPTSSSSRLIKMRIAWKVRVAGSCPRSRVRTFCATICASLRVVSIGLSARC       190       200       210       220       230       240        250m239.pep ATMARAIRRLNRSSPX ||||||| |||||||| a239 ATMARAIWRLNRSSPX       250The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 899>:

g240.seq 1 atgatagaag tcatacattt cttcggcgcc gaaacgcgca gacagtttgc 51ttgtgccgac gttggacgat ttctgcataa tgccgcgcac atccaaagag 101 gggtaaacatgggtatcatc gcgcacggga gacggtccga ttttataagg 151 ctgcgtattc agccgttcgttcaaatcggt tttgcccgca tccaatgcct 201 tcgcaatcac gaacggtttg attgccgaaccaggttcgat catatcggtt 251 acggcacggt tgcgccgctg ttcgctgtct gcccggccgggtctgttggg 301 atcgtaggcg ggcgtattgg ccaaggcgag gatttccccc gtgcgggcat351 ccaaaaccac caccgttccg gcttttgcct gatggtattc gaccgccttg 401ttcaactctt cataggccaa ggtctgaatc ctctgatcga gggaaaggat 451 gatgtctttgccgttttgcg gtgctttatt gcgcggggag tccaagctgt 501 ccacaatatt gccctgccggtcccgcaaaa caacttccgc gccgtcttcg 551 ccatacaggc tgtcttcaag cgaaagttccaaaccttcct gacctttgcc 601 gtcaatatcg gtaaatccga tgacgtgtgc aaacaggttgcccatcgggt 651 aatggcgttt taaThis corresponds to the amino acid sequence <SEQ ID 900; ORF 240.ng>:

g240.pep 1 MIEVIHFFGA ETRRQFACAD VGRFLHNAAH IQRGVNMGII AHGRRSDFIR 51LRIQPFVQIG FARIQCLRNH ERFDCRTRFD HIGYGTVAPL FAVCPAGSVG 101 IVGGRIGQGEDFPRAGIQNH HRSGFCLMVF DRLVQLFIGQ GLNPLIEGKD 151 DVFAVLRCFI ARGVQAVHNIALPVPQNNFR AVFAIQAVFK RKFQTFLTFA 201 VNIGKSDDVC KQVAHRVMAF *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 901>:

m240.seq 1 ATGATAGAAG TCATACATTT CTTCGGCACC GAAACGCGCA GACAGTTTGC 51TTGTGCCGAC GTTGGACGAT TTCTGCATGA TGCCGCGCAC ATCCAAAGAG 101 GGGTAAACATGGGTATCGCG CACGGGAGAC GGTCCGATTT TATAAGGCTG 151 CGTATTCAGC CGTTCGTTCAAATCGGTTTT GCCCGCATCC AATGCCTTCG 201 CAATCACAAA CGGTTTGATT GCCGAACCGGGTTCGATCAT ATCGGTTACG 251 GCACGGTTGC GCCGCTGTTC GCTGTCTGCC CGGCCGGGCCTGTTGGGATC 301 GTAGGCGGGC GTATTGGCCA AGGCGAGGAT TTCCCCCGTG CGGGCATCCA351 ArACCACCAC CGTTCCGGCT TTTGCCTGAT GGTATTCGAC CGCCTTGTTC 401AACTCTTCAT AGGCCAAGGT CTGAATCCTC TGATCGAGGG AAAGGATGAT 451 GTCTTTGCCGTTTTTCGGGG CTTTAkTGCG CGGGGAGTCC AAGCTGTCCA 501 CAATATTGCC CTGCCGGTCCCGCAAAACGA CTTCCGCGCC GTCTTCGCCA 551 TGCAAGCTGT CTTCAAGCGA AAGTTCCAAACCTTCCTGAC CTTTGCCGTC 601 AATATCGGTA AATCCGATGA CGTGTGCAAA CAGGTTGCCCATCGGGTAAT 651 GGCGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 902; ORF 240>:

m240.pep 1 MIEVIHFFGT ETRRQFACAD VGRFLHDAAH IQRGVNMGIA HGRRSDFIRL 51RIQPFVQIGF ARIQCLRNHK RFDCRTGFDH IGYGTVAPLF AVCPAGPVGI 101 VGGRIGQGEDFPRAGIQXHH RSGFCLMVFD RLVQLFIGQG LNPLIEGKDD 151 VFAVFRGFXA RGVQAVHNIALPVPQNDFRA VFAMQAVFKR KFQTFLTFAV 201 NIGKSDDVCK QVAHRVMAF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 240 shows 94.5% identity over a 220 aa overlap with a predicted ORF(ORF 240.ng) from N. gonorrhoeae:

m240/g240           10        20        30         40        50       59m240.pep   MIEVIHFFGTETRRQFACADVGRFLHDAAHIQRGVNMGI-AHGRRSDFIRLRIQPFVQIG  |||||||||:||||||||||||||||:|||||||||||| |||||||||||||||||||| g240  MIEVIHFFGAETRRQFACADVGRFLHNAAHIQRGVNMGIIAHGRRSDFIRLRIQPFVQIG          10        20        30        40        50        60 60        70        80        90       100       110      119 m240.pep  FARIQCLRNHKRFDCRTGFDHIGYGTVAPLFAVCPAGPVGIVGGRIGQGEDFPRAGIQXH  ||||||||||:|||||| ||||||||||||||||||| |||||||||||||||||||| | g240  FARIQCLRNHERFDCRTRFDHIGYGTVAPLFAVCPAGSVGIVGGRIGQGEDFPRAGIQNH          70        80        90       100       110       120120       130       140       150       160       170      179 m240.pep  HRSGFCLMVFDRLVQLFIGQGLNPLIEGKDDVFAVFRGFXARGVQAVHNIALPVPQNDFR  |||||||||||||||||||||||||||||||||||:| | |||||||||||||||||:|| g240  HRSGFCLMVFDRLVQLFIGQGLNPLIEGKDDVFAVLRCFIARGVQAVHNIALPVPQNNFR         130       140       150       160       170       180180       190       200       210       220 m240.pep  AVFAMQAVFKRKFQTFLTFAVNIGKSDDVCKQVAHRVMAFX  ||||:||||||||||||||||||||||||||||||||||| g240  AVFAIQAVFKRKFQTFLTFAVNIGKSDDVCKQVAHRVMAF         190       200       210       220The following partial DNA sequence was identified in N. meningitidis<SEQ ID 903>:

a240.seq 1 ATGATAGAAG TCATACATTT CTTCGGCACC GAAACGCGCA GACAGTTTGC 51TTGTGCCGAC GTTGGACGAT TTCTGCATGA TGCCGCGCAC ATCCAAAGAG 101 GGGTAAACATGGGTATCGCG CACGGGAGAC GGTCCGATTT TATAAGGCTG 151 CGTATTCAGC CGTTCGTTCAAATCGGTTTT GCCCGCATCC AATGCCTTCG 201 CAATCACAAA CGGTTTGATT GCCGAACCGGGTTCGATCAT ATCGGTTACG 251 GCACGGTTGC GCCGCTGTTC GCTGTCTGCC CGGCCGGGCCTGTTGGGATC 301 GTAGGCGGGC GTATTGGCCA AGGCGAGGAT TTCCCCCGTG CGGGCATCCA351 AAACCACCAC CGTTCCGGCT TTTGCCTGAT GGTATTCGAC CGCCTTGTTC 401AACTCTTCAT AGGCCAAGGT CTGAATCCTC TGATCGAGGG AAAGGATGAT 451 GTCTTTGCCGTTTTTCGGGG CTTTATTGCG CGGGGAGTCC AAGCTGTCCA 501 CAATATTGCC CTGCCGGTCCCGCAAAACGA CTTCCGCGCC GTCTTCGCCA 551 TGCAGGCTGT CTTCAAGCGA AAGTTCCAAACCTTCCTGAC CTTTGCCGTC 601 AATATCGGTA AATCCGATGA CGTGTGCAAA CAGGTTGCCCATCGGGTAAT 651 GGCGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 904; ORF 240.a>:

a240.pep 1 MIEVIHFFGT ETRRQFACAD VGRFLHDAAH IQRGVNMGIA HGRRSDFIRL 51RIQPFVQIGF ARIQCLRNHK RFDCRTGFDH IGYGTVAPLF AVCPAGPVGI 101 VGGRIGQGEDFPRAGIQNHH RSGFCLMVFD RLVQLFIGQG LNPLIEGKDD 151 VFAVFRGFIA RGVQAVHNIALPVPQNDFRA VFAMQAVFKR KFQTFLTFAV 201 NIGKSDDVCK QVAHRVMAF* m240/a24099.1% identity in 219 aa overlap        10        20        30        40        50        60 m240.pepMIEVIHFFGTETRRQFACADVGRFLHDAAHIQRGVNMGIAHGRRSDFIRLRIQPFVQIGF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a240MIEVIHFFGTETRRQFACADVGRFLHDAAHIQRGVNMGIAHGRRSDFIRLRIQPFVQIGF        10        20        30        40        50        60        70        80        90       100       110       120 m240.pepARIQCLRNHKRFDCRTGFDHIGYGTVAPLFAVCPAGPVGIVGGRIGQGEDFPRAGIQXHH||||||||||||||||||||||||||||||||||||||||||||||||||||||||| || a240ARIQCLRNHKRFDCRTGFDHIGYGTVAPLFAVCPAGPVGIVGGRIGQGEDFPRAGIQNHH        70        80        90       100       110       120       130       140       150       160       170       180 m240.pepRSGFCLMVFDRLVQLFIGQGLNPLIEGKDDVFAVFRGFXARGVQAVHNIALPVPQNDFRA|||||||||||||||||||||||||||||||||||||| ||||||||||||||||||||| a240RSGFCLMVFDRLVQLFIGQGLNPLIEGKDDVFAVFRGFIARGVQAVHNIALPVPQNDFRA       130       140       150       160       170       180       190       200       210       220 m240.pepVFAMQAVFKRKFQTFLTFAVNIGKSDDVCKQVAHRVMAFX|||||||||||||||||||||||||||||||||||||||| a240VFAMQAVFKRKFQTFLTFAVNIGKSDDVCKQVAHRVMAFX       190       200       210       220The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 905>:

g241.seq 1 ATGATAGAAG TCATACATTT CTTCGGCACC GAAACGCGCA GACAGTTTGC 51TTGTGCCGAC GTTGGACGAT TTCTGCATGA TGCCGCGCAC ATCCAAAGAG 101 GGGTAAACATGGGTATCGCG CACGGGAGAC GGTCCGATTT TATAAGGCTG 151 CGTATTCAGC CGTTCGTTCAAATCGGTTTT GCCCGCATCC AATGCCTTCG 201 CAATCACAAA CGGTTTGATT GCCGAACCGGGTTCGATCAT ATCGGTTACG 251 GCACGGTTGC GCCGCTGTTC GCTGTCTGCC CGGCCGGGCCTGTTGGGATC 301 GTAGGCGGGC GTATTGGCCA AGGCGAGGAT TTCCCCCGTG CGGGCATCCA351 ArACCACCAC CGTTCCGGCT TTTGCCTGAT GGTATTCGAC CGCCTTGTTC 401AACTCTTCAT AGGCCAAGGT CTGAATCCTC TGATCGAGGG AAAGGATGAT 451 GTCTTTGCCGTTTTTCGGGG CTTTAkTGCG CGGGGAGTCC AAGCTGTCCA 501 CAATATTGCC CTGCCGGTCCCGCAAAACGA CTTCCGCGCC GTCTTCGCCA 551 TGCAAGCTGT CTTCAAGCGA AAGTTCCAAACCTTCCTGAC CTTTGCCGTC 601 AATATCGGTA AATCCGATGA CGTGTGCAAA CAGGTTGCCCATCGGGTAAT 651 GGCGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 906; ORF 241.ng>:

g241.pep 1 MPTRPTRAAN PPTPTTWLQT AYCPRPPYRP PSVQTHTPHE PASSTCAAKS 51ANRRENSHNA QPTYLLHPSN KMPSETEQTL FRRHQIPPSC RQSVVVMTVR 101 TVDMTVCDFLIGCIAHAFNR SFKADFHACQ RMVAVHHRLA VGNIGYTIDD 151 NIAGFRIVRF KHHTDLDFNRERARIFNTDQ LRIMLTERIV GRKRHFDRIA 201 GILTVQRLFH QRENAVVTAVQIRNRFFGFI QKLIVGIIHL IMQRNHGIFC 251 NSHICPFRNS RLITGAF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 907>:

m241.seq (partial) 1 ..CGGCAATCAG TGGTGGTGAT GACCGTGCGG GCCGTGGACATGACCGTGTG 51   CGATTTCCTC ATCGGATGCA TCGCGCACGC TTTCAACTGT AGCCTTAAAG101   CGGATTTTCA TGCCTGCCAA AGGATGGTTG CCGTCCACCA CCGCCTTGCC 151  GTCGGCAACA TCGGTTACAC GATAGACGAC AACATCGCCG GTTTCAGGAT 201  CGTCGGCTTC AAACATCATG CCGACTTCGA CTTCAACAGG GAACACGCCC 251  GCATCTTCGA TACGGACCAA CTCCGGATCC TGCTCGCCGA ACGCATCGTC 301  GGGCGACAGC GCCACATCGA CCGTATCGCC GGCATCCTTA CCGTGCAACG 351  CCTCTTCCAC CAAAGGGAAA ATGCCGTCGT AACCGCCGTG CAGATACGCA 401  ATCGGTTCTT CGGTTTTGTC CAAAAGCTGA TTGTTGGCAT CATACATCTC 451  ATAATGCAGC GAAACCACGG AATTTTTCAC GATAGCCATA TTTGTCCTTT 501  CAGGAACAGC AGATTAATTA CAGGCGCATT CTAAThis corresponds to the amino acid sequence <SEQ ID 908; ORF 241>:

m241.pep (partial) 1 ..RQSVVVMTVR AVDMTVCDFL IGCIAHAFNC SLKADFHACQRMVAVHHRLA 51   VGNIGYTIDD NIAGFRIVGF KHHADFDFNR EHARIFDTDQ LRILLAERIV101   GRQRHIDRIA GILTVQRLFH QRENAVVTAV QIRNRFFGFV QKLIVGIIHL 151  IMQRNHGIFH DSHICPFRNS RLITGAF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 241 shows 91.5% identity over a 177 aa overlap with a predicted ORF(ORF 241.ng) from N. gonorrhoeae:

m241/g241                                       10        20        30m241.pep                               RQSVVVMTVRAVDMTVCDFLIGCIAHAFNC                              ||||||||||:|||||||||||||||||| g241QPTYLLHPSNKMPSETEQTLFRRHQIPPSCRQSVVVMTVRTVDMTVCDFLIGCIAHAFNR        70        80        90       100       110       120        40        50        60        70        80        90 m241.pepSLKADFHACQRMVAVHHRLAVGNIGYTIDDNIAGFRIVGFKHHADFDFNREHARIFDTDQ|:|||||||||||||||||||||||||||||||||||| ||||:|:|||||:||||:||| g241SFKADFHACQRMVAVHHRLAVGNIGYTIDDNIAGFRIVRFKHHTDLDFNRERARIFNTDQ       130       140       150       160       170       180       100       110       120       130       140       150 m241.pepLRILLAERIVGRQRHIDRIAGILTVQRLFHQRENAVVTAVQIRNRFFGFVQKLIVGIIHL|||:|:||||||:||:|||||||||||||||||||||||||||||||||:|||||||||| g241LRIMLTERIVGRKRHFDRIAGILTVQRLFHQRENAVVTAVQIRNRFFGFIQKLIVGIIHL       190       200       210       220       230       240       160       170 m241.pep IMQRNHGIFHDSHICPFRNSRLITGAFX||||||||| :||||||||||||||||| g241 IMQRNHGIFCNSHICPFRNSRLITGAFX       250       260The following partial DNA sequence was identified in N. meningitidis<SEQ ID 909>:

a241.seq 1 ATGCCAACAC GTCCAACTCG CGCCGCAAAG CATCCAACCC CGCCAACCTG 51GCTTCAGACG GCATACTGCC CTCGTCCGCC ATATCGTCCG CCGTCCGTGC 101 AAACGCATACACCGCATGAA CCGGCTTCCT CAACCTGCGC GGCAAAATCA 151 GCGAACCGAC GGGAAAATTTTCATAATGCC CAACCGACAT ACCTTCTCCA 201 TCCATCAAAC AAAATGCCGT CTGAAATGGAACAAACCCTT TTCAGACGGC 251 ATCAGATACC TCCAAGCTGC CGGCAATCAG TGGTGGTGATGACCGTGCGG 301 ACCGTGGACA TGACCGTGTG CGATTTCCTC ATCGGATGCA TCGCGCACAC351 TTTCAACCGT AGCCTTAAAG CGGATTTTCA TGCCTGCCAA AGGATGGTTG 401CCGTCCACCA CCGCCTTACC GTCGGCAACA TCGGTTACAC GATAGACGAC 451 AACATCGCCGGTTTCAGGAT CGTCGGCTTC AAACATCATG CCGACTTCGA 501 CTTCAACAGG GAACACGCCCGCATCTTCAA TACGGACCAA CTCCGGATCC 551 TGCTCGCCGA ACGCATCGTC GGGCGAAAGCGCCACATCGA CCGTATCGCC 601 GGCATCCTTA CCGTGCAACG CCTCTTCCAC CAAAGGGAAAATGCCGTCGT 651 AACCGCCGTG CAGATACGCA ATCGGTTCTT CGGTTTTGTC CAAAAGCTGA701 TTGTTGGCAT CATACATCTC ATAATGCAGC GAAACCACGG AATTCTTCAC 751GATAGCCATA TTTGTCCTTT CAGGAACAGC AGATTAATTA CAGGCGCATT 801 CTAAThis corresponds to the amino acid sequence <SEQ ID 910; ORF 241.a>:

a241.pep 1 MPTRPTRAAK HPTPPTWLQT AYCPRPPYRP PSVQTHTPHE PASSTCAAKS 51ANRRENFHNA QPTYLLHPSN KMPSEMEQTL FRRHQIPPSC RQSVVVMTVR 101 TVDMTVCDFLIGCIAHTFNR SLKADFHACQ RMVAVHHRLT VGNIGYTIDD 151 NIAGFRIVGF KHHADFDFNREHARIFNTDQ LRILLAERIV GRKRHIDRIA 201 GILTVQRLFH QRENAVVTAVQIRNRFFGFV QKLIVGIIHL IMQRNHGILH 251 DSHICPFRNS RLITGAF* m241/a241 96.0%identity in 177 aa overlap                                      10        20        30 m241.pep                              RQSVVVMTVRAVDMTVCDFLIGCIAHAFNC                              ||||||||||:|||||||||||||||:|| a241QPTYLLHPSNKMPSEMEQTLFRRHQIPPSCRQSVVVMTVRTVDMTVCDFLIGCIAHTFNR        70        80        90       100       110       120        40        50        60        70        80        90 m241.pepSLKADFHACQRMVAVHHRLAVGNIGYTIDDNIAGFRIVGFKHHADFDFNREHARIFDTDQ|||||||||||||||||||:||||||||||||||||||||||||||||||||||||:||| a241SLKADFHACQRMVAVHHRLTVGNIGYTIDDNIAGFRIVGFKHHADFDFNREHARIFNTDQ       130       140       150       160       170       180       100       110       120       130       140       150 m241.pepLRILLAERIVGRQRHIDRIAGILTVQRLFHQRENAVVTAVQIRNRFFGFVQKLIVGIIHL||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| a241LRILLAERIVGRKRHIDRIAGILTVQRLFHQRENAVVTAVQIRNRFFGFVQKLIVGIIHL       190       200       210       220       230       240       160       170 m241.pep IMQRNHGIFHDSHICPFRNSRLITGAFX||||||||:||||||||||||||||||| a241 IMQRNHGILHDSHICPFRNSRLITGAFX       250       260The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 911>:

g241-1.seq 1 ATGATAGAAG TCATACATTT CTTCGGCACC GAAACGCGCA GACAGTTTGC 51TTGTGCCGAC GTTGGACGAT TTCTGCATGA TGCCGCGCAC ATCCAAAGAG 101 GGGTAAACATGGGTATCGCG CACGGGAGAC GGTCCGATTT TATAAGGCTG 151 CGTATTCAGC CGTTCGTTCAAATCGGTTTT GCCCGCATCC AATGCCTTCG 201 CAATCACAAA CGGTTTGATT GCCGAACCGGGTTCGATCAT ATCGGTTACG 251 GCACGGTTGC GCCGCTGTTC GCTGTCTGCC CGGCCGGGCCTGTTGGGATC 301 GTAGGCGGGC GTATTGGCCA AGGCGAGGAT TTCCCCCGTG CGGGCATCCA351 ArACCACCAC CGTTCCGGCT TTTGCCTGAT GGTATTCGAC CGCCTTGTTC 401AACTCTTCAT AGGCCAAGGT CTGAATCCTC TGATCGAGGG AAAGGATGAT 451 GTCTTTGCCGTTTTTCGGGG CTTTAkTGCG CGGGGAGTCC AAGCTGTCCA 501 CAATATTGCC CTGCCGGTCCCGCAAAACGA CTTCCGCGCC GTCTTCGCCA 551 TGCAAGCTGT CTTCAAGCGA AAGTTCCAAACCTTCCTGAC CTTTGCCGTC 601 AATATCGGTA AATCCGATGA CGTGTGCAAA CAGGTTGCCCATCGGGTAAT 651 GGCGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 912; ORF 241-1.ng>:

g241-1.pep 1 MPTRPTRAAN PPTPTTWLQT AYCPRPPYRP PSVQTHTPHE PASSTCAAKS 51ANRRENSHNA QPTYLLHPSN KMPSETEQTL FRRHQIPPSC RQSVVVMTVR 101 TVDMTVCDFLIGCIAHAFNR SFKADFHACQ RMVAVHHRLA VGNIGYTIDD 151 NIAGFRIVRF KHHTDLDFNRERARIFNTDQ LRIMLTERIV GRKRHFDRIA 201 GILTVQRLFH QRENAVVTAVQIRNRFFGFI QKLIVGIIHL IMQRNHGIFC 251 NSHICPFRNS RLITGAF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 913>:

m241-1.seq 1 ATGCCAACAC GTCCAACTCG CGCTGCAAAC CCTCCAACCC CGCCAACCTG 51GCTTCAGACG GCATACTGCC CTCGTCCGCC ATATCGTCCG CCGTCCGTGC 101 AAACGCGTACACCGCGTGAA CCGGCTTCCT CAACCTGCGC GGCAAAATCA 151 GCGAACCGAC GGGAAAATTCTCATAATGCC CAACCGACAT ACCTTCTCCA 201 TCCATCAAAC AAAATGCCGT CTGAAACGGAACAAACCCTT TTCAGACGGC 251 ATCAGATACC TCCAAGCTGC CGGCAATCAG TGGTGGTGATGACCGTGCGG 301 GCCGTGGACA TGACCGTGTG CGATTTCCTC ATCGGATGCA TCGCGCACGC351 TTTCAACTGT AGCCTTAAAG CGGATTTTCA TGCCTGCCAA AGGATGGTTG 401CCGTCCACCA CCGCCTTGCC GTCGGCAACA TCGGTTACAC GATAGACGAC 451 AACATCGCCGGTTTCAGGAT CGTCGGCTTC AAACATCATG CCGACTTCGA 501 CTTCAACAGG GAACACGCCCGCATCTTCGA TACGGACCAA CTCCGGATCC 551 TGCTCGCCGA ACGCATCGTC GGGCGACAGCGCCACATCGA CCGTATCGCC 601 GGCATCCTTA CCGTGCAACG CCTCTTCCAC CAAAGGGAAAATGCCGTCGT 651 AACCGCCGTG CAGATACGCA ATCGGTTCTT CGGTTTTGTC CAAAAGCTGA701 TTGTTGGCAT CATACATCTC ATAATGCAGC GAAACCACGG AATTTTTCAC 751GATAGCCATA TTTGTCCTTT CAGGAACAGC AGATTAATTA CAGGCGCATT 801 CTAAThis corresponds to the amino acid sequence <SEQ ID 914; ORF 241-1>:

m241-1.pep 1 MPTRPTRAAN PPTPPTWLQT AYCPRPPYRP PSVQTRTPRE PASSTCAAKS 51ANRRENSHNA QPTYLLHPSN KMPSETEQTL FRRHQIPPSC RQSVVVMTVR 101 AVDMTVCDFLIGCIAHAFNC SLKADFHACQ RMVAVHHRLA VGNIGYTIDD 151 NIAGFRIVGF KHHADFDFNREHARIFDTDQ LRILLAERIV GRQRHIDRIA 201 GILTVQRLFH QRENAVVTAVQIRNRFFGFV QKLIVGIIHL IMQRNHGIFH 251 DSHICPFRNS RLITGAF* m241-1/g241-193.3% identity in 267 aa overlap        10        20        30        40        50        60 m241-1.pepMPTRPTRAANPPTPPTWLQTAYCPRPPYRPPSVQTRTPREPASSTCAAKSANRRENSHNA|||||||||||||| ||||||||||||||||||||:||:||||||||||||||||||||| g241MPTRPTRAANPPTPTTWLQTAYCPRPPYRPPSVQTHTPHEPASSTCAAKSANRRENSHNA        10        20        30        40        50        60        70        80        90       100       110       120 m241-1.pepQPTYLLHPSNKMPSETEQTLFRRHQIPPSCRQSVVVMTVRAVDMTVCDFLIGCIAHAFNC||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| g241QPTYLLHPSNKMPSETEQTLFRRHQIPPSCRQSVVVMTVRTVDMTVCDFLIGCIAHAFNR        70        80        90       100       110       120       130       140       150       160       170       180 m241-1.pepSLKADFHACQRMVAVHHRLAVGNIGYTIDDNIAGFRIVGFKHHADFDFNREHARIFDTDQ|:|||||||||||||||||||||||||||||||||||| ||||:|:|||||:||||:||| g241SFKADFHACQRMVAVHHRLAVGNIGYTIDDNIAGFRIVRFKHHTDLDFNRERARIFNTDQ       130       140       150       160       170       180       190       200       210       220       230       240 m241-1.pepLRILLAERIVGRQRHIDRIAGILTVQRLFHQRENAVVTAVQIRNRFFGFVQKLIVGIIHL|||:|:||||||:||:|||||||||||||||||||||||||||||||||:|||||||||| g241LRIMLTERIVGRKRHFDRIAGILTVQRLFHQRENAVVTAVQIRNRFFGFIQKLIVGIIHL       190       200       210       220       230       240       250       260 m241-1.pep IMQRNHGIFHDSHICPFRNSRLITGAFX||||||||| :||||||||||||||||| g241 IMQRNHGIFCNSHICPFRNSRLITGAFX       250       260The following partial DNA sequence was identified in N. meningitidis<SEQ ID 915>:

a241-1.seq 1 ATGCCAACAC GTCCAACTCG CGCCGCAAAG CATCCAACCC CGCCAACCTG 51GCTTCAGACG GCATACTGCC CTCGTCCGCC ATATCGTCCG CCGTCCGTGC 101 AAACGCATACACCGCATGAA CCGGCTTCCT CAACCTGCGC GGCAAAATCA 151 GCGAACCGAC GGGAAAATTTTCATAATGCC CAACCGACAT ACCTTCTCCA 201 TCCATCAAAC AAAATGCCGT CTGAAATGGAACAAACCCTT TTCAGACGGC 251 ATCAGATACC TCCAAGCTGC CGGCAATCAG TGGTGGTGATGACCGTGCGG 301 ACCGTGGACA TGACCGTGTG CGATTTCCTC ATCGGATGCA TCGCGCACAC351 TTTCAACCGT AGCCTTAAAG CGGATTTTCA TGCCTGCCAA AGGATGGTTG 401CCGTCCACCA CCGCCTTACC GTCGGCAACA TCGGTTACAC GATAGACGAC 451 AACATCGCCGGTTTCAGGAT CGTCGGCTTC AAACATCATG CCGACTTCGA 501 CTTCAACAGG GAACACGCCCGCATCTTCAA TACGGACCAA CTCCGGATCC 551 TGCTCGCCGA ACGCATCGTC GGGCGAAAGCGCCACATCGA CCGTATCGCC 601 GGCATCCTTA CCGTGCAACG CCTCTTCCAC CAAAGGGAAAATGCCGTCGT 651 AACCGCCGTG CAGATACGCA ATCGGTTCTT CGGTTTTGTC CAAAAGCTGA701 TTGTTGGCAT CATACATCTC ATAATGCAGC GAAACCACGG AATTCTTCAC 751GATAGCCATA TTTGTCCTTT CAGGAACAGC AGATTAATTA CAGGCGCATT 801 CTAAThis corresponds to the amino acid sequence <SEQ ID 916; ORF 241-1.a>:

a241-1.pep 1 MPTRPTRAAK HPTPPTWLQT AYCPRPPYRP PSVQTHTPHE PASSTCAAKS 51ANRRENFHNA QPTYLLHPSN KMPSEMEQTL FRRHQIPPSC RQSVVVMTVR 101 TVDMTVCDFLIGCIAHTFNR SLKADFHACQ RMVAVHHRLT VGNIGYTIDD 151 NIAGFRIVGF KHHADFDFNREHARIFNTDQ LRILLAERIV GRKRHIDRIA 201 GILTVQRLFH QRENAVVTAVQIRNRFFGFV QKLIVGIIHL IMQRNHGILH 251 DSHICPFRNS RLITGAF* m241-1/a241-195.1% identity in 267 aa overlap        10        20        30        40        50        60 m241-1.pepMPTRPTRAANPPTPPTWLQTAYCPRPPYRPPSVQTRTPREPASSTCAAKSANRRENSHNA |||||||||:||||||||||||||||||||||||:||:||||||||||||||||| ||| a241MPTRPTRAAKHPTPPTWLQTAYCPRPPYRPPSVQTHTPHEPASSTCAAKSANRRENFHNA        10        20        30        40        50        60        70        80        90       100       110       120 m241-1.pepQPTYLLHPSNKMPSETEQTLFRRHQIPPSCRQSVVVMTVRAVDMTVCDFLIGCIAHAFNC||||||||||||||| ||||||||||||||||||||||||:|||||||||||||||:|| a241QPTYLLHPSNKMPSEMEQTLFRRHQIPPSCRQSVVVMTVRTVDMTVCDFLIGCIAHTFNR        70        80        90       100       110       120       130       140       150       160       170       180 m241-1.pepSLKADFHACQRMVAVHHRLAVGNIGYTIDDNIAGFRIVGFKHHADFDFNREHARIFDTDQ|||||||||||||||||||:||||||||||||||||||||||||||||||||||||:||| a241SLKADFHACQRMVAVHHRLTVGNIGYTIDDNIAGFRIVGFKHHADFDFNREHARIFNTDQ       130       140       150       160       170       180       190       200       210       220       230       240 m241-1.pepLRILLAERIVGRQRHIDRIAGILTVQRLFHQRENAVVTAVQIRNRFFGFVQKLIVGIIHL||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| a241LRILLAERIVGRKRHIDRIAGILTVQRLFHQRENAVVTAVQIRNRFFGFVQKLIVGIIHL       190       200       210       220       230       240       250       260 m241-1.pep IMQRNHGIFHDSHICPFRNSRLITGAFX||||||||:||||||||||||||||||| a241 IMQRNHGILHDSHICPFRNSRLITGAFX       250       260The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 917>:

g242.seq 1 atgatcggcg aacttgttgt tttgttcgtg atcgagcact tcaagcaacg 51cgctggcggg atcgccccga aagtcgctgc ccaatttgtc gatttcgtcg 101 agcaggaacaacgggtttct tacgcctgct tttgccatat tctgcaaaat 151 cttgccgggc atagagccgatataggtacg gcggtgcccg cggatttcgc 201 tttcgtcgcg cacgccgccc aaggccatacggacatattt ccgccccgtt 251 gctttggcga tggattcgcc caaagaggtt ttgcccacgcccggagggcc 301 gaccaaacac agaatcggac ctttgagctt gtccatacgt ttttggacgg351 cgaggtattc caaaatccgt tctttgactt tttccaggcc gtagtggtcg 401gcatccagca ccagtccggc tttggcgatg tctttgctga cgcgggattt 451 tttcttccacggcagtccga gcagggtgtc gatgtagttg cgtacgacgg 501 tggattcggc agacatcggcggcatcattt tgagtttttt cagttcggac 551 aggcattttt cttccgcttc tttggtcatacccgcctttt tgatgcctgc 601 ctccaaggca tccagttcgc cgttttcgtc ttcttcgcccaattctttgt 651 gtatcgcttt aatctgttcg ttcagataat attcgcgttg ggatttttcc701 atttggcgtt tgacgcgtcc gcgtatgcgt ttttcggcct gcataatgtc 751gagttcggat tccagctttg ccagcaggaa ttccatccgt ttgccgattt 801 cgggaatctccaaaatctgt tggcgttgcg ccagtttcaa ctgcaaatgc 851 gctgcgaccg tatcggttagThis corresponds to the amino acid sequence <SEQ ID 918; ORF 242.ng>:

g242.pep 1 MIGELVVLFV IEHFKQRAGG IAPKVAAQFV DFVEQEQRVS YACFCHILQN 51LAGHRADIGT AVPADFAFVA HAAQGHTDIF PPRCFGDGFA QRGFAHARRA 101 DQTQNRTFELVHTFLDGEVF QNPFFDFFQA VVVGIQHQSG FGDVFADAGF 151 FLPRQSEQGV DVVAYDGGFGRHRRHHFEFF QFGQAFFFRF FGHTRLFDAC 201LQGIQFAVFV FFAQFFVYRF NLFVQIIFAL GFFHLAFDAS AYAFFGLHNV 251 EFGFQLCQQEFHPFADFGNL QNLLALRQFQ LQMRCDRIG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 919>:

m242.seq 1 ATGATCGGCA AACTTGTTGT TTTGTTCGGG ATCGAGCACT TCGAGCAACG 51CGCTGGCGGG ATCGCCTCGG AAGTCGTTAC CCAATTTGTC GATTTCGTCG 101 AGCAGGAACAAGGGGTTTTT CACGCCGGCT TTTGCCATAT TCTGCAAAAT 151 CTTACCGGGC ATAGAGCCGATATAGGTGCG GCGGTGTCCC CTGATTTCGC 201 TTTCGTCGCG CACGCCGCCC AAAGCCATGCGGACATATTT CCGCCCCGTT 251 GCTTTGGCGA TGGATTCGCC CAAAGAGGTT TTGCCCACGCCCGGAGGGCC 301 GACCAGGCAC AGAATCGGGC CTTTGAGTTT GTCCATACGT TTTTGGACGG351 CGAGGTATTC CAAAATCCGT TCTTTGACTT TTTCCAGGCC GTAGTGGTCG 401GCATCCAGCA CCAGTCCGGC TTTGGCGATG TCTTTGCTGA CGCGGGATTT 451 TTTCTTCCACGGCAGCTCGA GCAAAGTGTC GATGTAGTTG CGTACGACGG 501 TGGATTCCGC AGACATCGGTGGCATCATTT TGAGCTTTTT CAGTTCGGAC 551 AGGCATTTTT CTTCCGCTTC TTTGGTCATACCCGCCTTTT TGATATCTGC 601 TTCCAAGGCA TCCAGTTCGC CGTTTTCGTC TTCTTCGCCCAGTTCTTTGT 651 GTATCGCTTT AATCTGTTCG TTCAGATAAT ATTCGCGCTG GGATTTTTCC701 ATTTGGCGTT TGACGCGTCC GCGTATGCGT TTTTCGGCCT GCATAATGTC 751GAGTTCGGAT TCCAGCTGTG CCAGCAGGAA TTCCATCCGT TTGCCGATTT 801 CGGGAATTTCCAAAATCTGT TGGCGTTGCG CCAGTTTCAA CTGCAAATGC 851 GCTGCGACCG TATCGGTTAGThis corresponds to the amino acid sequence <SEQ ID 920; ORF 242>:

m242.pep 1 MIGKLVVLFG IEHFEQRAGG IASEVVTQFV DFVEQEQGVF HAGFCHILQN 51LTGHRADIGA AVSPDFAFVA HAAQSHADIF PPRCFGDGFA QRGFAHARRA 101 DQAQNRAFEFVHTFLDGEVF QNPFFDFFQA VVVGIQHQSG FGDVFADAGF 151 FLPRQLEQSV DVVAYDGGFRRHRWHHFELF QFGQAFFFRF FGHTRLFDIC 201FQGIQFAVFV FFAQFFVYRF NLFVQIIFAL GFFHLAFDAS AYAFFGLHNV 251 EFGFQLCQQEFHPFADFGNF QNLLALRQFQ LQMRCDRIG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 242 shows 90.3% identity over a 289 aa overlap with a predicted ORF(ORF 242.ng) from N. gonorrhoeae:

m242/g242 90.3% identity in 289 aa overlap        10        20        30        40        50        60 m242.pepMIGKLVVLFGIEHFEQRAGGIASEVVTQFVDFVEQEQGVFHAGFCHILQNLTGHRADIGA|||:||||| ||||:||||||| :|::|||||||||| | :| ||||||||:|||||||: g242MIGELVVLFVIEHFKQRAGGIAPKVAAQFVDFVEQEQRVSYACFCHILQNLAGHRADIGT        10        20        30        40        50        60        70        80        90       100       110       120 m242.pepAVSPDFAFVAHAAQSHADIFPPRCFGDGFAQRGFAHARRADQAQNRAFEFVHTFLDGEVF||  ||||||||||:|:|||||||||||||||||||||||||:|||:||:|||||||||| g242AVPADFAFVAHAAQGHTDIFPPRCFGDGFAQRGFAHARRADQTQNRTFELVHTFLDGEVF        70        80        90       100       110       120       130       140       150       160       170       180 m242.pepQNPFFDFFQAVVVGIQHQSGFGDVFADAGFFLPRQLEQSVDVVAYDGGFRRHRWHHFELF||||||||||||||||||||||||||||||||||| ||:|||||||||| ||| ||||:| g242QNPFFDFFQAVVVGIQHQSGFGDVFADAGFFLPRQSEQGVDVVAYDGGFGRHRRHHFEFF       130       140       150       160       170       180       190       200       210       220       230       240 m242.pepQFGQAFFFRFFGHTRLFDICFQGIQFAVFVFFAQFFVYRFNLFVQIIFALGFFHLAFDAS|||||||||||||||||| |:||||||||||||||||||||||||||||||||||||||| g242QFGQAFFFRFFGHTRLFDACLQGIQFAVFVFFAQFFVYRFNLFVQIIFALGFFHLAFDAS       190       200       210       220       230       240       250       260       270       280       290 m242.pepAYAFFGLHNVEFGFQLCQQEFHPFADFGNFQNLLALRQFQLQMRCDRIGX|||||||||||||||||||||||||||||:|||||||||||||||||||| g242AYAFFGLHNVEFGFQLCQQEFHPFADFGNLQNLLALRQFQLQMRCDRIGX       250       260       270       280The following partial DNA sequence was identified in N. meningitidis<SEQ ID 921>:

a242.seq 1 ATGATCGGCG AACTTGTTGT TTTGCTCGGG ATCAAGCACT TCGAGCAACG 51CGCTGGCGGG ATCGCCCCGG AAGTCGCTAN CCAATTTGTC GATTTCGTCG 101 AGCAGGAACAATGGGTTTTT TACGCCGGCT TTTGCCATAT TCTGCAAAAT 151 CTTACCGGGC ATGGAGCCGATATAGGTGCG GCGGTGTCCC CGGATTTCGC 201 TTTCGTCGCG CACGCCGCCC AAAGCCATGCGGACATATTT CCGCCCCGTT 251 GCTTTGGCGA TGGATTCGCC CAAAGAGGTT TTGCCCACGCCTGGAGGGCC 301 GACCAGGCAC AGAATCGGGC CTTTGAGTTT GTCCATACGT TTTTGGACGG351 CGAGGTATTC CAAAATCCGT TCTTTGACTT TTTCCAGGCC GTAGTGGTCG 401GTATCCAGCA CCAATCCGGC TTTGGCGATG TCTTTGCTGA CGCGGGATTT 451 TTTCTTCCACGGCAGTTCGA GCAGGGTGTC GATGTAGTTG CGTACGACGG 501 TGGATTCGGC AGACATCGGCGGCATCATTT TGAGCTTTTT CAGTTCGGAC 551 AGGCATTTTT CTTCCGCTTC TTTGGTCATACCCGCCTTTT TGATATCTGC 601 TTCCAAGGCA TCCAGTTCGC CGTTTTCGTC TTCTTCGCCCAGTTCTTTGT 651 GTATCGCTTT AATCTGTTCG TTCAGATAAT ATTCGCGCTG GGATTTTTCC701 ATTTGGCGTT TGACGCGTCC GCGTATGCGT TTTTCGGCCT GCATAATGTC 751GAGTTCGGAT TCCAGCTGTG CCAGCAGGAA TTCCATCCGT TTGCCGATTT 801 CGGGAATTTCCAAAATCTGT TGGCGTTGCG CCAGTTTCAA CTGCAAATGC 851 GCTGCGACCG TATCGGTTAGThis corresponds to the amino acid sequence <SEQ ID 922; ORF 242.a>:

a242.pep 1 MIGELVVLLG IKHFEQRAGG IAPEVAXQFV DFVEQEQWVF YAGFCHILQN 51LTGHGADIGA AVSPDFAFVA HAAQSHADIF PPRCFGDGFA QRGFAHAWRA 101 DQAQNRAFEFVHTFLDGEVF QNPFFDFFQA VVVGIQHQSG FGDVFADAGF 151 FLPRQFEQGV DVVAYDGGFGRHRRHHFELF QFGQAFFFRF FGHTRLFDIC 201FQGIQFAVFV FFAQFFVYRF NLFVQIIFAL GFFHLAFDAS AYAFFGLHNV 251 EFGFQLCQQEFHPFADFGNF QNLLALRQFQ LQMRCDRIG* m242/a242 95.2% identity in 289 aaoverlap         10        20        30        40        50        60m242.pep MIGKLVVLFGIEHFEQRAGGIASEVVTQFVDFVEQEQGVFHAGFCHILQNLTGHRADIGA|||:||||:||:|||||||||| ||::|||||||||| ||:||||||||||||| ||||| a242MIGELVVLLGIKHFEQRAGGIAPEVAXQFVDFVEQEQWVFYAGFCHILQNLIGHGADIGA        10        20        30        40        50        60        70        80        90       100       110       120 m242.pepAVSPDFAFVAHAAQSHADIFPPRCFGDGFAQRGFAHARRADQAQNRAFEFVHTFLDGEVF||||||||||||||||||||||||||||||||||||| |||||||||||||||||||||| a242AVSPDFAFVAHAAQSHADIFPPRCFGDGFAQRGFAHAWRADQAQNRAFEFVHTFLDGEVF        70        80        90       100       110       120       130       140       150       160       170       180 m242.pepQNPFFDFFQAVVVGIQHQSGFGDVFADAGFFLPRQLEQSVDVVAYDGGFRRHRWHHFELF|||||||||||||||||||||||||||||||||||:||:|||||||||| ||| |||||| a242QNPFFDFFQAVVVGIQHQSGFGDVFADAGFFLPRQFEQGVDVVAYDGGFGRHRRHHFELF       130       140       150       160       170       180       190       200       210       220       230       240 m242.pepQFGQAFFFRFFGHTRLFDICFQGIQFAVFVFFAQFFVYRFNLFVQIIFALGFFHLAFDAS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a242QFGQAFFFRFFGHTRLFDICFQGIQFAVFVFFAQFFVYRFNLFVQIIFALGFFHLAFDAS       190       200       210       220       230       240       250       260       270       280       290 m242.pepAYAFFGLHNVEFGFQLCQQEFHPFADFGNFQNLLALRQFQLQMRCDRIGX|||||||||||||||||||||||||||||||||||||||||||||||||| a242AYAFFGLHNVEFGFQLCQQEFHPFADFGNFQNLLALRQFQLQMRCDRIGX       250       260       270       280       290The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 923>:

g243.seq 1 ATGGTaatcg tctGGTTGCc cgAGTTaccg CCGATGCCGG CGACGATGGG 51CATCAGCGCG GCGAGTGCGA CGATTTTTTC gatactgcCT TCAAACGCGC 101 CGATGACGCGGCTGGCGAGG AAGGCGGTGC AGAGGTTGAC GGCGAGCCAC 151 ATCCAGCGGT TTTTGACGGAATCCAAGACG GGGGCGAACA GGTCTTCCTC 201 TTCCTGCAAA CCTGCCATGT TCAACATATCCGCTTCGGAT TCTTCGCGGA 251 TCACGTCCAC CATCTCGTCG ATGGTAATCc tgCCGATGAGCTTTTTGTTT 301 TCATCAACGA CGGGCGCGGT AACCAAGTCG TAGThis corresponds to the amino acid sequence <SEQ ID 924; ORF 243.ng>:

g243.pep 1 MVIVWLPELP PMPATMGISA ASATIFSILP SNAPMTRLAR KAVQRLTASH 51IQRFLTESKT GANRSSSSCK PAMFNISASD SSRITSTISS MVILPMSFLF 101 SSTTGAVTKS *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 925>:

m243.seq 1 ATGGTAATCG TCTGGTTGCC CGAGTTACCG CCTATGCCGG CGACGATGGG 51CATCAGCGCG GyGAGTGCGA CGATTTTTTC GATGCTGCCT TCAAACGCGC 101 CGATAACACGGyTGGCGAGG AAGGCGGTGC AGAGGTTGAC GGCGAGCCAC 151 ATCCAGyGGT TTTTCACCGAATCCCACACG GGGGCGAAyA GGTCTTCCTC 201 TTCCTGCAAA CCCGCCATAT TCAGCATATCCGCTTCCGAT TCTTCGCGGA 251 TCACGTCCAC CATCTCGTCG ATGGTAATCC TGCCGATGAGCTTTTTGTTT 301 TCATCGACGA CGGGCGCGGT AACCAAGTCG TAGThis corresponds to the amino acid sequence <SEQ ID 926; ORF 243>:

m243.pep 1 MVIVWLPELP PMPATMGISA XSATIFSMLP SNAPITRLAR KAVQRLTASH 51IQXFFTESHT GANRSSSSCK PAIFSISASD SSRITSTISS MVILPMSFLF 101 SSTTGAVTKS *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 243 shows 92.7% identity over a 110 aa overlap with a predicted ORF(ORF 243.ng) from N. gonorrhoeae:

m243/g243         10        20        30        40        50        60m243.pep MVIVWLPELPPMPATMGISAXSATIFSMLPSNAPITRLARKAVQRLTASHIQXFFTESHT|||||||||||||||||||| ||||||:||||||:||||||||||||||||| |:|||:| g243MVIVWLPELPPMPATMGISAASATIFSILPSNAPMTRLARKAVQRLTASHIQRFLTESKT        10        20        30        40        50        60        70        80        90       100       110 m243.pepGANRSSSSCKPAIFSISASDSSRITSTISSMVILPMSFLFSSTTGAVTKSX||||||||||||:|:|||||||||||||||||||||||||||||||||||| g243GANRSSSSCKPAMFNISASDSSRITSTISSMVILPMSFLFSSTTGAVTKSX        70        80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 927>:

a243.seq 1 ATGGTAATCG TCTGGTTGCC CGAGTTACCG CCTATGCCGG CGACGATGGG 51CATCAGCGCG GCGAGTGCGA CGATTTTTTC GATGCTGCCT TCAAACGCGC 101 CGATAACACGGCTGGCGAGG AAGGCGGTGC AGAGGTTGAC GGCGAGCCAC 151 ATCCAGCGGT TTTTGACGGAATCCAAGACG GGGGCGAATA AGTCTTCCTC 201 TTCTTGCAAA CCCGCCATAT TCAACATATCCGCTTCGGAT TCTTCGCGGA 251 TCACGTCCAC CATTTCGTCA ACGGTCACCC TGCCGATGAGCTTTTTGTTT 301 TCATCGACGA CGGGCGCGGT AACCAAGTCA TAGThis corresponds to the amino acid sequence <SEQ ID 928; ORF 243.a>:

a243.pep 1 MVIVWLPELP PMPATMGISA ASATIFSMLP SNAPITRLAR KAVQRLTASH 51IQRFLTESKT GANKSSSSCK PAIFNISASD SSRITSTISS TVTLPMSFLF 101 SSTTGAVTKS *m243/a243 92.7% identity in 110 aa overlap        10        20        30        40        50        60 m243.pepMVIVWLPELPPMPATMGISAXSATIFSMLPSNAPITRLARKAVQRLTASHIQXFFTESHT|||||||||||||||||||| ||||||||||||||||||||||||||||||| |:|||:| a243MVIVWLPELPPMPATMGISAASATIFSMLPSNAPITRLARKAVQRLTASHIQRFLTESKT        10        20        30        40        50        60        70        80        90       100       110 m243.pepGANRSSSSCKPAIFSISASDSSRITSTISSMVILPMSFLFSSTTGAVTKSX|||:||||||||||:||||||||||||||| | |||||||||||||||||| a243GANKSSSSCKPAIFNISASDSSRITSTISSTVTLPMSFLFSSTTGAVTKSX        70        80        90       100       110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 929>:

g244.seq 1 atgccgcctg aagcccggcc ggcgggttca gacggcattg ccgctttact 51tcgatcggtt tatacgcaaa acgcgcttca ggaaataaat cagattattc 101 cccagacgccttcaggcttc cttccgtgcc accgtaacca tagccgggcg 151 caacacacgg tcggacagggtataaccctt cttcatcaca ccaaccacgg 201 tattgggttc ctgctcactg gccaccgcctgcatcgcctg atggatattc 251 ggatcgagct tatcgcccgc tttaggattg atttccttgatttgcgtggc 301 atcaaacgcc ttctgcaact cattcaaagt catctgcaca cccattttca351 gcgcatcgaa attaccgctc tgatccaaaa gcgccatttc cagataatcc 401ttgaccggca acatttccac ggcaaacttc tgtccggcga acttgtgcgt 451 atcggcaatttcctgctggt ggcggcggcg caggttttgc tcgtttgcca 501 aagcgcgcag ttgttcgtctttcaactgcg cttccagctc ggcaatccgc 551 gcctgcaaat cctcataagc cggctcggcggcagcctgtt cctgtacacc 601 gtccgcattt cctactgtct cgacggtttc caccgcctccacattttcaa 651 ccgcttcttc actgttttgc tgctgtgtct gttcgctcat atcgtatccc701 tcaaaacaaa ttggaaatca aaatccggtt attacccgag caagataagg 751acattttcaa gaaacttcaa gcaaaggcag gaaatttcac atccgccgcc 801 gaataccctaccgcaaaaac catataaacg gtaaThis corresponds to the amino acid sequence <SEQ ID 930; ORF 244.ng>:

g244.pep 1 MPPEARPAGS DGIAALLRSV YTQNALQEIN QIIPQTPSGF LPCHRNHSRA 51QHTVGQGITL LHHTNHGIGF LLTGHRLHRL MDIRIELIAR FRIDFLDLRG 101 IKRLLQLIQSHLHTHFQRIE ITALIQKRHF QIILDRQHFH GKLLSGELVR 151 IGNFLLVAAA QVLLVCQSAQLFVFQLRFQL GNPRLQILIS RLGGSLFLYT 201 VRISYCLDGFHRLHIFNRFF TVLLLCLFAH IVSLKTNWKS KSGYYPSKIR 251 TFSRNFKQRQ EISHPPPNTLPQKPYKR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 931>:

m244.seq 1 ATGCCGTCTG AAGCCCGACA GGCGGGTTCA GACGGCATTG CCGCTTTACT 51TCGATCGGTT TATACGCAAA ACGCGCTTCA GGAAATAAAT CAGATTATTC 101 CCCAGACGCCTTCAGGCTTC CTTCTGCGCC ACCGTAACCA TAGCCGGGCG 151 CAACACGCGG TCGGACAGCGTATAACCCTT CTTCATCACA CCCACCACGG 201 TATTCGGCTC CTGTTCGCTT GCCACCGCCTGCATCGCCTG ATGGATATTC 251 GGATCGAGCT TATCGCCCGC TTTAGGGTTG ATTTCCTTGATTTGCGTAGC 301 ATCAAATGCT TTCTGCAACT CGTTCAAAGT CATCTGCACG CCCATTTTCA351 GCGCATCGAA ATTGCCGCTC TGATCCAAAA GCGCCATTTC CAGATAATCC 401TTGACCGGCA GCATTTCCAC GGCAAACTTC TGTCCGGCGA ACTTGTGCGT 451 ATCCGCAATTTyCTGCTGGT GGCGGCGGCG CAGGTTTTGC TCGTTTGCCA 501 AAGCGCGCTG CTCGTCTTTCAACTGCGTTT CCAGCTCGGC AATCCGCGCC 551 TGCAAATCCT CATAAGCCGG CTCTGCGGCAGCCTGTTCCT GCACACCGTC 601 CGCATTTCCT ACTGTTTCGA CGGTTTCCAC CGCCTCCACATTTTCAACCG 651 CTTCTTCACT GTTTTGCTGC TGTGTCTGTT CGCTCATATC GTATCCCTTA701 AAACAAATTG GAAATCAAAA TCCAGTTATT ACCCGCGCAA GATAAGGACA 751TTTTCAAGAA ACTTCAAkCA AAAkCAGAGA ATTTCAAATT CATTTTCAAA 801 TCCCCTACCGAAAAAATAAT ATAGACGGTA AThis corresponds to the amino acid sequence <SEQ ID 932; ORF 244>:

m244.pep 1 MPSEARQAGS DGIAALLRSV YTQNALQEIN QIIPQTPSGF LLRHRNHSRA 51QHAVGQRITL LHHTHHGIRL LFACHRLHRL MDIRIELIAR FRVDFLDLRS 101 IKCFLQLVQSHLHAHFQRIE IAALIQKRHF QIILDRQHFH GKLLSGELVR 151 IRNFLLVAAA QVLLVCQSALLVFQLRFQLG NPRLQILISR LCGSLFLHTV 201 RISYCFDGFHRLHIFNRFFT VLLLCLFAHI VSLKTNWKSK SSYYPRKIRT 251 FSRNFXQXQR ISNSFSNPLPKKXYRR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 244 shows 86.3% identity over a 277 aa overlap with a predicted ORF(ORF 244.ng) from N. gonorrhoeae:

M244/G244         10        20        30        40        50        60m244.pep MPSEARQAGSDGIAALLRSVYTQNALQEINQIIPQTPSGFLLRHRNHSRAQHAVGQRITL|| ||| ||||||||||||||||||||||||||||||||||  |||||||||:||| ||| g244MPPEARPAGSDGIAALLRSVYTQNALQEINQIIPQTPSGFLPCHRNHSRAQHTVGQGITL        10        20        30        40        50        60        70        80        90       100       110       120 m244.pepLHHTHHGIRLLFACHRLHRLMDIRIELIARFRVDFLDLRSIKCFLQLVQSHLHAHFQRIE||||:||| :|:: ||||||||||||||||||:||||||:|| :|||:|||||:|||||| g244LHHTNHGIGFLLTGHRLHRLMDIRIELIARFRIDFLDLRGIKRLLQLIQSHLHTHFQRIE        70        80        90       100       110       120       130       140       150       160       170       180 m244.pepIAALIQKRHFQIILDRQHFHGKLLSGELVRIRNFLLVAAAQVLLVCQSAALLVFQLRFQL|:||||||||||||||||||||||||||||| ||||||||||||||||| |:|||||||| g244ITALIQKRHFQIILDRQHFHGKLLSGELVRIGNFLLVAAAQVLLVCQSAQLFVFQLRFQL       130       140       150       160       170       180       190       200       210       220       230       240 m244.pepGNPRLQILISRLCGSLFLHTVRISYCFDGFHRLHIFNRFFTVLLLCLFAHIVSLKTNWKS|||||||||||| |||||:|||||||:||||||||||||||||||||||||||||||||| g244GNPRLQILISRLGGSLFLYTVRISYCLDGFHRLHIFNRFFTVLLLCLFAHIVSLKTNWKS       190       200       210       220       230       240       250       260       270 m244.pepKSSYYPRKIRTFSRNFXQXQRISNSFSNPLPKKXYRRX||:||| ||||||||| | |:||:   | ||:| |:|| g244KSGYYPSKIRTFSRNFKQRQEISHPPPNTLPQKPYKRX        250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 933>:

a244.seq 1 ATGCCGTCTG AAGCCCGACA GGCGGGTTCA GACGGCATTG CCGCTTTACT 51TCGATCGGTT TATACGCAAA ACGCGCTTCA GGAAATAAAT CAGATTATTC 101 CCCAGACGCCTTCAGGCTTC CTTCTGTGCC ACCGTAACCA TAGCCGGGCG 151 CAACACGCGG TCGGACAGCGTATAACCCTT CTTCATCACG CCCACCACGG 201 TATTGGGTTC CTGTTCGCTT GCCACCGCCTGCATCGCCTG ATGGATATTC 251 GGATCGAGCT TATCGCCCGC TTTAGGATTG ATTTCCTTGATTTGCGTAGC 301 ATCAAATGCT TTCTGCAACT CGTTCAAAGT CATCTGCACG CCCATTTTCA351 GCGCATCGAA ATTGCCGCTC TGATCCAAAA GCGCCATTTC CAGATAATCC 401TTGACCGGCA GCATTTCCAC GGCAAACTTC TGTCCGGCGA ACTTGTGCGT 451 ATCCGCAATTTCCTGCTGGT GGCGGCGGCG CAGGTTTTGC TCGTTTGCCA 501 AAGCGCGCAG CTGCTCGTCTTTCAACTGCG CTTCCAGCTC GGCAATCCGC 551 GCCTGCAAAT CCTCATAAGC CGGCTCTGCGGCAGCCTGTT CCTGCACACC 601 GTCCGCATTT CCTACTGTCT CGACGGTTTC CACCGCCTCCACATTTTCAA 651 CCGCTTCTTC ACTGTTTTGC TGCTGTGTCT GTTCGCTCAT ATCGTATCCC701 TTAAAACAAA TTGGAAATCA AAATCCAGTT ATTACCCGCG CAAGATAAGG 751ACATTTTCAA GAAACTTCAA GCAAAGGCAG AGAATTTCAA ATTCATTTTC 801 AAATCCCCTACCGAAAAAAT AATATAGACG GTAAThis corresponds to the amino acid sequence <SEQ ID 934; ORF 244.a>:

a244.pep 1 MPSEARQAGS DGIAALLRSV YTQNALQEIN QIIPQTPSGF LLCHRNHSRA 51QHAVGQRITL LHHAHHGIGF LFACHRLHRL MDIRIELIAR FRIDFLDLRS 101 IKCFLQLVQSHLHAHFQRIE IAALIQKRHF QIILDRQHFH GKLLSGELVR 151IRNFLLVAAA QVLLVCQSAQ LLVFQLRFQL GNPRLQILIS RLCGSLFLHT 201 VRISYCLDGFHRLHIFNRFF TVLLLCLFAH IVSLKTNWKS KSSYYPRKIR 251 TFSRNFKQRQ RISNSFSNPLPKK*YRR* m244/a244 96.8% identity in 277 aa overlap          10        20        30        40        50        60 m244.pep  MPSEARQAGSDGIAALLRSVYTQNALQEINQIIPQTPSGFLLRHRNHSRAQHAVGQRITL  |||||||||||||||||||||||||||||||||||||||||| ||||||||||||||||| a244  MPSEARQAGSDGIAALLRSVYTQNALQEINQIIPQTPSGFLLCHRNHSRAQHAVGQRITL          10        20        30        40        50        60          70        80        90       100       110       120 m244.pep  LHHTHHGIRLLFACHRLHRLMDIRIELIARFRVDFLDLRSIKCFLQLVQSHLHAHFQRIE  |||:|||| :||||||||||||||||||||||:||||||||||||||||||||||||||| a244  LHHAHHGIGFLFACHRLHRLMDIRIELIARFRIDFLDLRSIKCFLQLVQSHLHAHFQRIE          70        80        90       100       110       120         130       140       150       160       170       179 m244.pep  IAALIQKRHFQIILDRQHFHGKLLSGELVRIRNFLLVAAAQVLLVCQSA-LLVFQLRFQL  ||||||||||||||||||||||||||||||||||||||||||||||||| |||||||||| a244  IAALIQKRHFQIILDRQHFHGKLLSGELVRIRNFLLVAAAQVLLVCQSAQLLVFQLRFQL         130       140       150       160       170       179180       190       200       210       220       230      239 m244.pep  GNPRLQILISRLCGSLFLHTVRISYCFDGFHRLHIFNRFFTVLLLCLFAHIVSLKTNWKS  ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| a244  GNPRLQILISRLCGSLFLHTVRISYCLDGFHRLHIFNRFFTVLLLCLFAHIVSLKTNWKS         190       200       210       220       230       240240       250       260       270 m244.pep  KSSYYPRKIRTFSRNFXQXQRISNSFSNPLPKKXYRRX  |||||||||||||||| | ||||||||||||||||||| a244  KSSYYPRKIRTFSRNFKQRQRISNSFSNPLPKKXYRRX240      250       260       270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 935>:

g244-1.seq 1 atgccgcctg aagcccggcc ggcgggttca gacggcattg ccgctttact 51tcgatcggtt tatacgcaaa acgcgcttca ggaaataaat cagattattc 101 cccagacgccttcaggcttc cttccgtgcc accgtaacca tagccgggcg 151 caacacacgg tcggacagggtataaccctt cttcatcaca ccaaccacgg 201 tattgggttc ctgctcactg gccaccgcctgcatcgcctg atggatattc 251 ggatcgagct tatcgcccgc tttaggattg atttccttgatttgcgtggc 301 atcaaacgcc ttctgcaact cattcaaagt catctgcaca cccattttca351 gcgcatcgaa attaccgctc tgatccaaaa gcgccatttc cagataatcc 401ttgaccggca acatttccac ggcaaacttc tgtccggcga acttgtgcgt 451 atcggcaatttcctgctggt ggcggcggcg caggttttgc tcgtttgcca 501 aagcgcgcag ttgttcgtctttcaactgcg cttccagctc ggcaatccgc 551 gcctgcaaat cctcataagc cggctcggcggcagcctgtt cctgtacacc 601 gtccgcattt cctactgtct cgacggtttc caccgcctccacattttcaa 651 ccgcttcttc actgttttgc tgctgtgtct gttcgctcat atcgtatccc701 tcaaaacaaa ttggaaatca aaatccggtt attacccgag caagataagg 751acattttcaa gaaacttcaa gcaaaggcag gaaatttcac atccgccgcc 801 gaataccctaccgcaaaaac catataaacg gtaaThis corresponds to the amino acid sequence <SEQ ID 936; ORF 244-1.ng>:

g244-1.pep 1 MPPEARPAGS DGIAALLRSV YTQNALQEIN QIIPQTPSGF LPCHRNHSRA 51QHTVGQGITL LHHTNHGIGF LLTGHRLHRL MDIRIELIAR FRIDFLDLRG 101 IKRLLQLIQSHLHTHFQRIE ITALIQKRHF QIILDRQHFH GKLLSGELVR 151 IGNFLLVAAA QVLLVCQSAQLFVFQLRFQL GNPRLQILIS RLGGSLFLYT 201 VRISYCLDGFHRLHIFNRFF TVLLLCLFAH IVSLKTNWKS KSGYYPSKIR 251 TFSRNFKQRQ EISHPPPNTLPQKPYKR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 937>:

m244-1.seq 1 ATGCCGTCTG AAGCCCGACA GGCGGGTTCA GACGGCATTG CCGCTTTACT 51TCGATCGGTT TATACGCAAA ACGCGCTTCA GGAAATAAAT CAGATTATTC 101 CCCAGACGCCTTCAGGCTTC CTTCTGCGCC ACCGTAACCA TAGCCGGGCG 151 CAACACGCGG TCGGACAGCGTATAACCCTT CTTCATCACA CCCACCACGG 201 TATTCGGCTC CTGTTCGCTT GCCACCGCCTGCATCGCCTG ATGGATATTC 251 GGATCGAGCT TATCGCCCGC TTTAGGGTTG ATTTCCTTGATTTGCGTAGC 301 ATCAAATGCT TTCTGCAACT CGTTCAAAGT CATCTGCACG CCCATTTTCA351 GCGCATCGAA ATTGCCGCTC TGATCCAAAA GCGCCATTTC CAGATAATCC 401TTGACCGGCA GCATTTCCAC GGCAAACTTC TGTCCGGCGA ACTTGTGCGT 451 ATCCGCAATTTyCTGCTGGT GGCGGCGGCG CAGGTTTTGC TCGTTTGCCA 501 AAGCGCGCTG CTCGTCTTTCAACTGCGTTT CCAGCTCGGC AATCCGCGCC 551 TGCAAATCCT CATAAGCCGG CTCTGCGGCAGCCTGTTCCT GCACACCGTC 601 CGCATTTCCT ACTGTTTCGA CGGTTTCCAC CGCCTCCACATTTTCAACCG 651 CTTCTTCACT GTTTTGCTGC TGTGTCTGTT CGCTCATATC GTATCCCTTA701 AAACAAATTG GAAATCAAAA TCCAGTTATT ACCCGCGCAA GATAAGGACA 751TTTTCAAGAA ACTTCAAkCA AAAkCAGAGA ATTTCAAATT CATTTTCAAA 801 TCCCCTACCGAAAAAATAAThis corresponds to the amino acid sequence <SEQ ID 938; ORF 244-1>:

m244-1.pep 1 MPSEARQAGS DGIAALLRSV YTQNALQEIN QIIPQTPSGF LLRHRNHSRA 51QHAVGQRITL LHHTHHGIRL LFACHRLHRL MDIRIELIAR FRVDFLDLRS 101 IKCFLQLVQSHLHAHFQRIE IAALIQKRHF QIILDRQHFH GKLLSGELVR 151 IRNFLLVAAA QVLLVCQSALLVFQLRFQLG NPRLQILISR LCGSLFLHTV 201 RISYCFDGFHRLHIFNRFFT VLLLCLFAHI VSLKTNWKSK SSYYPRKIRT 251 FSRNFXQXQR ISNSFSNPLPKK* m244-1/G244-1 86.3% identity in 277 aa overlap        10        20        30        40        50        60 m244-1.pepMPSEARQAGSDGIAALLRSVYTQNALQEINQIIPQTPSGFLLRHRNHSRAQHAVGQRILL|| ||| ||||||||||||||||||||||||||||||||||  |||||||||:||| ||| g244-1MPPEARPAGSDGIAALLRSVYTQNALQEINQIIPQTPSGFLPCHRNHSRAQHTVGQGILL        10        20        30        40        50        60        70        80        90       100       110       120 m244-1.pepLHHTHHGIRLLFACHRLHRLMDIRIELIARFRVDFLDLRSIKCFLQLVQSHLHAHFQRIE||||:||| :|:: ||||||||||||||||||:||||||:|| :|||:|||||:|||||| g244-1LHHTNHGIGFLLTGHRLHRLMDIRIELIARFRIDFLDLRGIKRLLQLIQSHLHTHFQRIE        70        80        90       100       110       120       130       140       150       160       170       180 m244-1.pepIAALIQKRHFQIILDRQHFHGKLLSGELVRIRNFLLVAAAQVLLVCQSAALLVFQLRFQL|:||||||||||||||||||||||||||||| ||||||||||||||||| |:|||||||| g244-1ITALIQKRHFQIILDRQHFHGKLLSGELVRIGNFLLVAAAQVLLVCQSAQLFVFQLRFQL       130       140       150       160       170       180       190       200       210       220       230       240 m244-1.pepGNPRLQILISRLCGSLFLHTVRISYCFDGFHRLHIFNRFFTVLLLCLFAHIVSLKTNWKS|||||||||||| |||||:|||||||:||||||||||||||||||||||||||||||||| g244-1GNPRLQILISRLGGSLFLYTVRISYCLDGFHRLHIFNRFFTVLLLCLFAHIVSLKTNWKS       190       200       210       220       230       240         250       260       270 m244-1.pepKSSYYPRKIRTFSRNFXQXQRISNSFSNPLPKKX ||:||| ||||||||| | |:||:   | ||:|g244-1 KSGYYPSKIRTFSRNFKQRQEISHPPPNTLPQKPYKRX         250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 939>:

a244-1.seq 1 ATGCCGTCTG AAGCCCGACA GGCGGGTTCA GACGGCATTG CCGCTTTACT 51TCGATCGGTT TATACGCAAA ACGCGCTTCA GGAAATAAAT CAGATTATTC 101 CCCAGACGCCTTCAGGCTTC CTTCTGTGCC ACCGTAACCA TAGCCGGGCG 151 CAACACGCGG TCGGACAGCGTATAACCCTT CTTCATCACG CCCACCACGG 201 TATTGGGTTC CTGTTCGCTT GCCACCGCCTGCATCGCCTG ATGGATATTC 251 GGATCGAGCT TATCGCCCGC TTTAGGATTG ATTTCCTTGATTTGCGTAGC 301 ATCAAATGCT TTCTGCAACT CGTTCAAAGT CATCTGCACG CCCATTTTCA351 GCGCATCGAA ATTGCCGCTC TGATCCAAAA GCGCCATTTC CAGATAATCC 401TTGACCGGCA GCATTTCCAC GGCAAACTTC TGTCCGGCGA ACTTGTGCGT 451 ATCCGCAATTTCCTGCTGGT GGCGGCGGCG CAGGTTTTGC TCGTTTGCCA 501 AAGCGCGCAG CTGCTCGTCTTTCAACTGCG CTTCCAGCTC GGCAATCCGC 551 GCCTGCAAAT CCTCATAAGC CGGCTCTGCGGCAGCCTGTT CCTGCACACC 601 GTCCGCATTT CCTACTGTCT CGACGGTTTC CACCGCCTCCACATTTTCAA 651 CCGCTTCTTC ACTGTTTTGC TGCTGTGTCT GTTCGCTCAT ATCGTATCCC701 TTAAAACAAA TTGGAAATCA AAATCCAGTT ATTACCCGCG CAAGATAAGG 751ACATTTTCAA GAAACTTCAA GCAAAGGCAG AGAATTTCAA ATTCATTTTC 801 AAATCCCCTACCGAAAAAAT AAThis corresponds to the amino acid sequence <SEQ ID 940; ORF 244-1.a>:

a244-1.pep 1 MPSEARQAGS DGIAALLRSV YTQNALQEIN QIIPQTPSGF LLCHRNHSRA 51QHAVGQRITL LHHAHHGIGF LFACHRLHRL MDIRIELIAR FRIDFLDLRS 101 IKCFLQLVQSHLHAHFQRIE IAALIQKRHF QIILDRQHFH GKLLSGELVR 151IRNFLLVAAA QVLLVCQSAQ LLVFQLRFQL GNPRLQILIS RLCGSLFLHT 201 VRISYCLDGFHRLHIFNRFF TVLLLCLFAH IVSLKTNWKS KSSYYPRKIR 251 TFSRNFKQRQ RISNSFSNPLPKK* m244-1/a244-1 96.8% identity in 274 aa overlap          10        20        30        40        50        60m244-1.pep  MPSEARQAGSDGIAALLRSVYTQNALQEINQIIPQTPSGFLLRHRNHSRAQHAVGQRILL  |||||||||||||||||||||||||||||||||||||||| ||||||||||||||||| a244-1  MPSEARQAGSDGIAALLRSVYTQNALQEINQIIPQTPSGFLLCHRNHSRAQHAVGQRILL          10        20        30        40        50        60          70        80        90       100       110       120m244-1.pep  LHHTHHGIRLLFACHRLHRLMDIRIELIARFRVDFLDLRSIKCFLQLVQSHLHAHFQRIE  |||:|||| :||||||||||||||||||||||:||||||||||||||||||||||||||| a244-1  LHHAHHGIGFLFACHRLHRLMDIRIELIARFRIDFLDLRSIKCFLQLVQSHLHAHFQRIE          70        80        90       100       110       120         130       140       150       160       170       179m244-1.pep  IAALIQKRHFQIILDRQHFHGKLLSGELVRIRNFLLVAAAQVLLVCQSA-LLVFQLRFQL  ||||||||||||||||||||||||||||||||||||||||||||||||| |||||||||| a244-1  IAALIQKRHFQIILDRQHFHGKLLSGELVRIRNFLLVAAAQVLLVCQSAQLLVFQLRFQL         130       140       150       160       170       180180       190       200       210       220       230      239m244-1.pep  GNPRLQILISRLCGSLFLHTVRISYCFDGFHRLHIFNRFFTVLLLCLFAHIVSLKTNWKS  ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| a244-1  GNPRLQILISRLCGSLFLHTVRISYCLDGFHRLHIFNRFFTVLLLCLFAHIVSLKTNWKS         190       200       210       220       230       240240       250       260       270 m244-1.pep  KSSYYPRKIRTFSRNFXQXQRISNSFSNPLPKKX  |||||||||||||||| | ||||||||||||||| a244-1  KSSYYPRKIRTFSRNFKQRQRISNSFSNPLPKKX          250       260       270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 941>:

g246.seq 1 atgtacgggc ggaacggtag tactcaagcg gccgttgcct tcgttttcga 51ccagacacag cgtgcccgtt tcggcaacgg cgaagtttac gccgctcaag 101 ccgacatcggcagtgctgta aatatcgcgc agggctttgc gggcgaatcc 151 ggtcagttgg tccacgtcgtctgtaagcgg tgtgccgagg ttttggtgga 201 acagttcgct gacctgttct ttggttttatggattgcggg catcacgata 251 tgggtcggtt tttcgcctgc catttggacg ataaactcgcccaagtcgct 301 ttccaccgcc ttaatgcctt ttgcttcaag ataatggttc agctcgattt351 cttcgctgac catggatttg cctttgacca tcagcttgcc gtttttggct 401gtgatgatgt cgtggataat ttggcaggct tcggcagggg tttccgccca 451 gtgtactttcacgcccaact tagtcaggtt ttcttccaac tgctccagca 501 gcgcgggtaaThis corresponds to the amino acid sequence <SEQ ID 942; ORF 246.ng>:

g246.pep 1 MYGRNGSTQA AVAFVFDQTQ RARFGNGEVY AAQADIGSAV NIAQGFAGES 51GQLVHVVCKR CAEVLVEQFA DLFFGFMDCG HHDMGRFFAC HLDDKLAQVA 101 FHRLNAFCFKIMVQLDFFAD HGFAFDHQLA VFGCDDVVDN LAGFGRGFRP 151 VYFHAQLSQV FFQLLQQRG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 943>:

m246.seq (partial) 1ATGCACGGGC GGTACGGTGG TACTCAAGCG ACCGTTgCTT CGTTTTCCAC 51CAGACACAGC GTACCTGTTT CAGCAACGGC AAAGTTTACG CCACTCAAAC 101CGACATCGGC AGTGCTGTAA ATATCGCGCA GTGCTTTACG GGCGAAGCCG 151GTCAGTTGGT CTACATCGTC TGTCAGCGGC GTACCGAGGT TTTGGTGGAA 201CAGTTCGCTA ACCTGTTCTT TGGTTTTGTG GATAGCAGGC ATCACGATAT 251GGGTCGGTTT TTCGCCTGCC ATTTGGACGA TGAACTCGCC CAAGTCGCTT 301TCTACCGCTT TAATGCyTTT TGCTTCAAGA TAATGrTTCA GCTCGATTTC 351CTCGCTGACC ATCGATTTGC CTTTGACCAT CAGCTTGCCG TTTTTGGCTG 401TGATGATGTC GTGGATAATT TGGCAGGCTT CGGTCGGGGT TTCTGCCCG...This corresponds to the amino acid sequence <SEQ ID 944; ORF 246>:

m246.pep (partial) 1MHGRYGGTQA TVAFVFHQTQ RTCFSNGKVY ATQTDIGSAV NIAQCFTGEA 51GQLVYIVCQR RTEVLVEQFA NLFFGFVDSR HHDMGRFFAC HLDDELAQVA 101FYRFNAFCFK IMXQLDFLAD HRFAFDHQLA VFGCDDVVDN LAGFGRGFCP...Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 246 shows 80.0% identity over a 150 aa overlap with a predicted ORF(ORF 246.ng) from N. gonorrhoeae:

m246/g246         10        20        30        40        50        60m246.pep MHGRYGGTQATVAFVFHQTQRTCFSNGKVYATQTDIGSAVNIAQCFTGEAGQLVYIVCQR|:|| |:|||:||||| ||||: |:||:|||:|:|||||||||| |:||:||||::||:| g246MYGRNGSTQAAVAFVFDQTQRARFGNGEVYAAQADIGSAVNIAQGFAGESGQLVHVVCKR        10        20        30        40        50        60        70        80        90       100       110       120 m246.pepRTEVLVEQFANLFFGFVDSRHHDMGRFFACHLDDELAQVAFYRFNAFCFKIMXQLDFLAD :||||||||:|||||:|  ||||||||||||||:||||||:|:|||||||| ||||:|| g246CAEVLVEQFADLFFGFMDCGHHDMGRFFACHLDDKLAQVAFHRLNAFCFKIMVQLDFFAD        70        80        90       100       110       120       130       140       150 m246.pep HRFAFDHQLAVFGCDDVVDNLAGFGRGFCP ||||||||||||||||||||||||||| | g246HGFAFDHQLAVFGCDDVVDNLAGFGRGFRPVYFHAQLSQVFFQLLQQRGX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 945>:

a246.seq (partial) 1ATGCACGGGC GGAACGGTGG TACTCAAGCG ACCGTTGCCT TCGTTTTCCA 51CCAGACACAG CGTACCTGTT TCAGCAACGG CGAAGTTCAC GCCACTCAAA 101CCGACATCGG CAGTGCTGTA AATATCGCGC AGTGCTTTAC GGGCGAAGCC 151GGTCAGTTGG TCTACGTCGT CCGTTAACGG TGTGCCGAGG TTTTGGTGGA 201ACAGTTCGCT AACCTGTTCT TTGGTTTTAT GGATTGCGGG CATCACGATA 251TGGGTCGGTT TTTCACCTGC CATTTGGACG ATGAACTCGC CCAAGTCGCT 301TTCCACCGCT TTAATGCCTT TTGCTTCAAG ATAATGGTTC AGCTCGATTT 351CCTCGCTGAC CATCGATTTG CCTTTGACCA TCAGCTTGCC GTTTTTGGCT 401GTGATGATGT CGTGGATGAT TTCGCAGGCT TCGGCCGGTG TTTCCGCCCA 451GTGTACTTTT ACGCCCAACT TGGTCAGGTT TTCTTCCAGC TGCTCCAGCA 501 GThis corresponds to the amino acid sequence <SEQ ID 946; ORF 246.a>:

a246.pep (partial) 1MHGRNGGTQA TVAFVFHQTQ RTCFSNGEVH ATQTDIGSAV NIAQCFTGEA 51GQLVYVVR*R CAEVLVEQFA NLFFGFMDCG HHDMGRFFTC HLDDELAQVA 101FHRFNAFCFK IMVQLDFLAD HRFAFDHQLA VFGCDDVVDD FAGFGRCFRP 151VYFYAQLGQV FFQLLQQ m246/a246 88.0% identity in 150 aa overlap        10        20        30        40        50        60 m246.pepMHGRYGGTQATVAFVFHQTQRTCFSNGKVYATQTDIGSAVNIAQCFTGEAGQLVYIVCQR ||||||||||||||||||||||||||:|:|||||||||||||||||||||||||:|  | a246MHGRNGGTQATVAFVFHQTQRTCFSNGEVHATQTDIGSAVNIAQCFTGEAGQLVYVVRXR        10        20        30        40        50        60        70        80        90       100       110       120 m246.pepRTEVLVEQFANLFFGFVDSRHHDMGRFFACHLDDELAQVAFYRFNAFCFKIMXQLDFLAD :||||||||||||||:|  ||||||||:||||||||||||:|||||||||| ||||||| a246CAEVLVEQFANLFFGFMDCGHHDMGRFFTCHLDDELAQVAFHRFNAFCFKIMVQLDFLAD        70        80        90       100       110       120       130       140       150 m246.pep HRFAFDHQLAVFGCDDVVDNLAGFGRGFCP|||||||||||||||||||::||||| | | a246HRFAFDHQLAVFGCDDVVDDFAGFGRCFRPVYFYAQLGQVFFQLLQQ       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 947>:

g247.seq 1 atgaaacgta aaatgctaaa cgtaccaaag ggcggttatg atggtatgaa 51gggttttacc attgttgaat ttctggttgc gggcctgctc agtataattg 101tcctgatagc ggtcgtatcg agttacttta catcccggaa attaaatgat 151gtggcaaacg agcgtcttgc cattcaacag gatttgcgga atgcggcaac 201attaattgtc cgcgatgcaa gaatggcggg gagcttcggt tgtttcaata 251tgtccgagca tactaaagac gatattgttg attcaagtaa tcaaactcaa 301tctaaccttg caaaacccgg tgccaaacaa gaaaatcccc ttttttcctt 351aaaaaggagc ggcatggata aacaactgat tcccgttgct gaatccatag 401atattaaata tccgggtttt atccagcgcc ttaacgcatt ggttttccaa 451tacggtatcg atgatcttga tgcgagtgct gagactgttg tagtcagcag 501ctgttccaaa atagcaaaac cgggtaagaa aatatctacc ttgcaagaag 551caaagagtgc attacagatt actaatgatg ataaacaaaa tggaaatatc 601acccgtcaga aacatgtggt caatgcctat gcggtcggca ggtttggcaa 651taatgaggaa agtttgttcc gcttccaatt ggatgataag ggcaagtggg 701gtaatcctca gttgctcgtg aaaaaggtta aacgtatgga tgtgcggtat 751atttatgttt ccggttgtcc tgaagatgaa gatgccggca aagaggaaaa 801attcagatat acgaataaat tcgacaaatc caaaaatgct gttacgcctg 851ccggggtgga ggttttattg gatagcggcc ttaatgccaa gattgccgct 901tcttcagaca atagtattta tgcttaccgt atcaatgcga caatacgcgg 951gggaaatgta tgcgcaaaca gaacactttg aThis corresponds to the amino acid sequence <SEQ ID 948; ORF 247.ng>:

g247.pep 1 MKRKMLNVPK GGYDGMKGFT IVEFLVAGLL SIIVLIAVVS SYFTSRKLND 51VANERLAIQQ DLRNAATLIV RDARMAGSFG CFNMSEHTKD DIVDSSNQTQ 101SNLAKPGAKQ ENPLFSLKRS GMDKQLIPVA ESIDIKYPGF IQRLNALVFQ 151YGIDDLDASA ETVVVSSCSK IAKPGKKIST LQEAKSALQI TNDDKQNGNI 201TRQKHVVNAY AVGRFGNNEE SLFRFQLDDK GKWGNPQLLV KKVKRMDVRY 251IYVSGCPEDE DAGKEEKFRY TNKFDKSKNA VTPAGVEVLL DSGLNAKIAA 301SSDNSIYAYR INATIRGGNV CANRTL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 949>:

m247.seq (partial) 1ATsAGACGTA AAATGCTAAA CGTwsyArAA GGCAGTTATG ATGGTATGAA 51AGGTTTTACC ATTATTGAAT TTTTGGTTGC GGGCCTGCTC AGTATGATTG 101TCCTGATGGC GGTCGGATCG AGTTACTTCA CATCCCGGAA ATTAAATGAT 151GCGGCAAACG AGCGTCTTGC CGCGCAACAG GATTTGCGGA ATGCGGCAAC 201ATTGATTGTC CGCGATGCGA GAATGGCAGG CGGCTTCGGT TGTTTCAATA 251TGTCCGAGCA TCCTGCAACT GATGTTATTC CCGATACGAC GCAACAAAAT 301TCTCCTTTTT CCTTAAAAAG GAACGGTATA GATAAACTTA TTCCCATAGC 351GGAATCTTCA AATATCAATT ATCAGAATTT TTTCCAGGTT GGTAGCGCAT 401TGATTTTTCA ATACGGAATC GATGATGTTA ATGCAAGCAC CGCGACTACC 451GTCGTCAGCA GCTGTGCCGC AATATCGAAA CCGGGCAAGC AAATCCCTAC 501TTTAGAAGAT GCAAAAAAAG AATTGAAGAT TCCGGATCAG GATAAGGAGC 551AAAATGGCAA TATAGCGCGT CAAAGGCATG TGGTCAATGC CTATGCGGTC 601GGCAGGATTG CCGATGAGGA AAGTTTGTTC CGCTTCCAAT TGGATGATAA 651GGGCAAGTGG GGTAATCCTC AGTTGC...This corresponds to the amino acid sequence <SEQ ID 950; ORF 247>:

m247.pep (partial) 1XRRKMLNVXX GSYDGMKGFT IIEFLVAGLL SMIVLMAVGS SYFTSRKLND 51AANERLAAQQ DLRNAATLIV RDARMAGGFG CFNMSEHPAT DVIPDTTQQN 101SPFSLKRNGI DKLIPIAESS NINYQNFFQV GSALIFQYGI DDVNASTATT 151VVSSCAAISK PGKQIPTLED AKKELKIPDQ DKEQNGNIAR QRHVVNAYAV 201GRIADEESLF RFQLDDKGKW GNPQL....Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 247 shows 69.3% identity over a 238 aa overlap with a predicted ORF(ORF 247.ng) from N. gonorrhoeae:

m247/g247           10        20        30        40        50        60m247.pep   XRRKMLNVXXGSYDGMKGFTIIEFLVAGLLSMIVLMAVGSSYFTSRKLNDAANERLAAQQ   :||||||  |:|||||||||:|||||||||:|||:|| |||||||||||:|||||| || g247  MKRKMLNVPKGGYDGMKGFTIVEFLVAGLLSIIVLIAVVSSYFTSRKLNDVANERLAIQQ          10        20        30        40        50        60          70        80        90       100 m247.pep  DLRNAATLIVRDARMAGGFGCFNMSEHPATDVI------------PDTTQQNSPFSLKRN  |||||||||||||||||:|||||||||   |::            | : |:|  |||||: g247  DLRNAATLIVRDARMAGSFGCFNMSEHTKDDIVDSSNQTQSNLAKPGAKQENPLFSLKRS          70        80        90       100       110       120 110        120       130       140       150       160 m247.pep  GIDK-LIPIAESSNINYQNFFQVGSALIFQYGIDDVNASTATTVVSSCAAISKPGKQIPT   |:|||||:||| :|:| :|:|  :||:|||||||::||: |:|||||: |:||||:| | g247  GMDKQLIPVAESIDIKYPGFIQRLNALVFQYGIDDLDASAETVVVSSCSKIAKPGKKIST         130       140       150       160       170       180  170       180       190       200       210       220 m247.pep  LEDAKKELKIPDQDKEQNGNIARQRHVVNAYAVGRIAD-EESLFRFQLDDKGKWGNPQL  |::||: |:| ::|| |||||:||:||||||||||::: |||||||||||||||||||| g247  LQEAKSALQITNDDK-QNGNITRQKHVVNAYAVGRFGNNEESLFRFQLDDKGKWGNPQLL         190        200       210       220       230 g247  VKKVKRMDVRYIYVSGCPEDEDAGKEEKFRYTNKFDKSKNAVTPAGVEVLLDSGLNAKIA240       250       260       270       280       290The following partial DNA sequence was identified in N. meningitidis<SEQ ID 951>:

a247.seq 1 ATGAGACGTA AAATGCTAAA CGTACCAAAA GGCAATTATG ATGGTATGAA 51GGGTTTTACC ATTATTGAAT TTTTGGTTGC GGGCATGCTC AGTATGATTG 101TCCTGATGGC GGTCGGATCG AGTTACTTCA CATCCCGGAA ATTAAATGAT 151GCGGCAAACG AGCGTCTTTC CGCGCAACAG GATTTGCGGA ATGCGGCAAC 201ATTGATTGTC CGCGATGCAA GAATGGCAGG GGGCTTCGGT TGTTTCAATA 251TGTCCGAGCA TACTAAAAAT GATATTATTG TTGATCCAAG TAAGCAAACT 301CAACATGTCC CTGTAAAACC CGGTGCCAAA CAAGAAAATC CCCTTTTTTC 351TTTAGAGTGG GCTAATACTA ATAATACTAA TAATAATACA GCTAAATTGA 401TTCCTATTGC TGAATCCACA GATATTAAAT ATCCGGGTTT TGCCCAGGCT 451CGTCCGGCAT TGATTTTCCA ATACGGCATC GATGATCTTG ATGCGAGTGC 501TGAGACTGTT GTAGTCAGCA GCTGTTCCAA AATAGCAAAA CCGGGTAAGA 551AAATATCTAC CTTGCAAGAA GCAAAGAGTG CATTACAGAT TACTAATGAT 601GATAAACAAA ATGGAAATAT CACCCGTCAA AGGCATGTGG TCAATGCCTA 651TGCGGTCGGC AGGATTGCCG GTGAGGAAGG TTTGTTCCGC TTCCAATTGG 701ATGATAAGGG CAAGTGGGGT AATCCTCAGT TGCTCGTGAA AAAGATTAGA 751CATATGAAAG TGCGGTATAT CTATGTTTCC GACTGTCCTG AAGATGACGA 801TGCCGGCAAA GAGGAAAAAT TCAAATATAC GGGTACATTC GACAGCTCCA 851CAAATGCTGT TACGCCCGCC GGGGTGGAGG TTTTATTGAG TANCGGTACT 901GATACCAAGA TTGCCGCTTC TTCAGACAAT CATATTTATG CTTACCGTAT 951CGATGCGACA ATACGCGGGG GAAATGTATG CGCAAACAGA ACACTTTGAThis corresponds to the amino acid sequence <SEQ ID 952; ORF 247.a>:

a247.pep 1 MRRKMLNVPK GNYDGMKGFT IIEFLVAGML SMIVLMAVGS SYFTSRKLND 51AANERLSAQQ DLRNAATLIV RDARMAGGFG CFNMSEHTKN DIIVDPSKQT 101QHVPVKPGAK QENPLFSLEW ANTNNTNNNT AKLIPIAEST DIKYPGFAQA 151RPALIFQYGI DDLDASAETV VVSSCSKIAK PGKKISTLQE AKSALQITND 201DKQNGNITRQ RHVVNAYAVG RIAGEEGLFR FQLDDKGKWG NPQLLVKKIR 251HMKVRYIYVS DCPEDDDAGK EEKFKYTGTF DSSTNAVTPA GVEVLLSXGT 301DTKIAASSDN HIYAYRIDAT IRGGNVCANR TL* m247/a24770.9% identity in 244 aa overlap          10        20        30        40        50        60 m247.pep  XRRKMLNVXXGSYDGMKGFTIIEFLVAGLLSMIVLMAVGSSYFTSRKLNDAANERLAAQQ   |||||||  |:||||||||||||||||:|||||||||||||||||||||||||||:||| a247  MRRKMLNVPKGNYDGMKGFTIIEFLVAGMLSMIVLMAVGSSYFTSRKLNDAANERLSAQQ          10        20        30        40        50        60          70        80        90                    100 m247.pep  DLRNAATLIVRDARMAGGFGCFNMSEHPATDVI-------------PDTTQQNSPFSLK-  |||||||||||||||||||||||||||  :|:|             | : |:|  |||: a247  DLRNAATLIVRDARMAGGFGCFNMSEHTKNDIIVDPSKQTQHVPVKPGAKQENPLFSLEW          70        80        90       100       110       120         110       120       130       140       150       160 m247.pep  RNGIDKLIPIAESSNINYQNFFQVGSALIFQYGIDDVNASTATTVVSSCAAISK         |:  ||||||||::|:| :| |:  ||||||||||::||: |:|||||: |:| a247  ANTNNTNNNTAKLIPIAESTDIKYPGFAQARPALIFQYGIDDLDASAETVVVSSCSKIAK         130       140       150       160       170       180         170       180       190       200       210       220 m247.pep  PGKQIPTLEDAKKELKIPDQDKEQNGNIARQRHVVNAYAVGRIADEESLFRFQLDDKGKW   |||:|||::||: |:| ::|| |||||:||||||||||||||| ||:|||||||||||| a247  PGKKISTLQEAKSALQITNDDK-QNGNITRQRHVVNAYAVGRIAGEEGLFRFQLDDKGKW         190       200        210       220       230 m247.pep   GNPQL  ||||| a247  GNPQLLVKKIRHMKVRYIYVSDCPEDDDAGKEEKFKYTGTFDSSTNAVTPAGVEVLLSXG240       250       260       270       280       290The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 953>:

g247-1.seq (partial) .. 1CCCGGTGCCA AACAAGAAAA TCCCCTTTTT TCCTTAAAAA GGAGCGGCAT 51GGATAAACAA CTGATTCCCG TTGCTGAATC CATAGATATT AAATATCCGG 101GTTTTATCCA GCGCCTTAAC GCATTGGTTT TCCAATACGG TATCGATGAT 151CTTGATGCGA GTGCTGAGAC TGTTGTAGTC AGCAGCTGTT CCAAAATAGC 201AAAACCGGGT AAGAAAATAT CTACCTTGCA AGAAGCAAAG AGTGCATTAC 251AGATTACTAA TGATGATAAA CAAAATGGAA ATATCACCCG TCAGAAACAT 301GTGGTCAATG CCTATGCGGT CGGCAGGTTT GGCAATAATG AGGAAAGTTT 351GTTCCGCTTC CAATTGGATG ATAAGGGCAA GTGGGGTAAT CCTCAGTTGC 401TCGTGAAAAA GGTTAAACGT ATGGATGTGC GGTATATTTA TGTTTCCGGT 451TGTCCTGAAG ATGAAGATGC CGGCAAAGAG GAAAAATTCA GATATACGAA 501TAAATTCGAC AAATCCAAAA ATGCTGTTAC GCCTGCCGGG GTGGAGGTTT 551TATTGGATAG CGGCCTTAAT GCCAAGATTG CCGCTTCTTC AGACAATAGT 601ATTTATGCTT ACCGTATCAA TGCGACAATA CGCGGGGGAA ATGTATGCGC 651AAACAGAACA CTTTGAThis corresponds to the amino acid sequence <SEQ ID 954; ORF 247-1.ng>:

g247-1.pep (partial) .. 1PGAKQENPLF SLKRSGMDKQ LIPVAESIDI KYPGFIQRLN ALVFQYGIDD 51LDASAETVVV SSCSKIAKPG KKISTLQEAK SALQITNDDK QNGNITRQKH 101VVNAYAVGRF GNNEESLFRF QLDDKGKWGN PQLLVKKVKR MDVRYIYVSG 151CPEDEDAGKE EKFRYTNKFD KSKNAVTPAG VEVLLDSGLN AKIAASSDNS 201IYAYRINATI RGGNVCANRT L*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 955>:

m247-1.seq 1 ATGAGACGTA AAATGCTAAA CGTACCAAAA GGCAGTTATG ATGGTATGAA 51AGGTTTTACC ATTATTGAAT TTTTGGTTGC GGGCCTGCTC AGTATGATTG 101TCCTGATGGC GGTCGGATCG AGTTACTTCA CATCCCGGAA ATTAAATGAT 151GCGGCAAACG AGCGTCTTGC CGCGCAACAG GATTTGCGGA ATGCGGCAAC 201ATTGATTGTC CGCGATGCGA GAATGGCAGG CGGCTTCGGT TGTTTCAATA 251TGTCCGAGCA TCCTGCAACT GATGTTATTC CCGATACGAC GCAACAAAAT 301TCTCCTTTTT CCTTAAAAAG GAACGGTATA GATAAACTTA TTCCCATAGC 351GGAATCTTCA AATATCAATT ATCAGAATTT TTTCCAGGTT GGTAGCGCAT 401TGATTTTTCA ATACGGAATC GATGATGTTA ATGCAAGCAC CGCGACTACC 451GTCGTCAGCA GCTGTGCCGC AATATCGAAA CCGGGCAAGC AAATCCCTAC 501TTTAGAAGAT GCAAAAAAAG AATTGAAGAT TCCGGATCAG GATAAGGAGC 551AAAATGGCAA TATAGCGCGT CAAAGGCATG TGGTCAATGC CTATGCGGTC 601GGCAGGATTG CCGATGAGGA AGGTTTGTTC CGCTTCCAAT TGGATGATAA 651GGGCAAGTGG GGTAATCCTC AGTTGCTCGT GAAAAAGGTT AGACATATGA 701AAGTGCGGTA TATCTATGTT TCCGGCTGTC CTGAAGATGA CGATGCCGGC 751AAAGAGGAAA CATTCAAATA TACGGATAAA TTCGACAGCG CCCAAAATGC 801TGTTACGCCC GCCGGGGTGG AGGTTTTATT GAGTAGCGGT ACTGATACCA 851AGATTGCCGC TTCTTCAGAC AATCATATTT ATGCTTACCG TATCGATGCG 901ACAATACGCG GGGGAAATGT ATGCGCAAAC AGAACACTTT GAThis corresponds to the amino acid sequence <SEQ ID 956; ORF 247-1>:

m247-1.pep 1 MRRKMLNVPK GSYDGMKGFT IIEFLVAGLL SMIVLMAVGS SYFTSRKLND 51AANERLAAQQ DLRNAATLIV RDARMAGGFG CFNMSEHPAT DVIPDTTQQN 101SPFSLKRNGI DKLIPIAESS NINYQNFFQV GSALIFQYGI DDVNASTATT 151VVSSCAAISK PGKQIPTLED AKKELKIPDQ DKEQNGNIAR QRHVVNAYAV 201GRIADEEGLF RFQLDDKGKW GNPQLLVKKV RHMKVRYIYV SGCPEDDDAG 251KEETFKYTDK FDSAQNAVTP AGVEVLLSSG TDTKIAASSD NHIYAYRIDA 301TIRGGNVCAN RTL* m247-1/g247-1 72.1% identity in 222 aa overlap       70        80        90       100        110        120 m247-1.pep  NAATLIVRDARMAGGFGCFNMSEHPATDVIPDTTQQNSPFSLKRNGIDK-LIPIAESSNI                                | : |:|  |||||:|:|| |||:||| :| g247-1                                PGAKQENPLFSLKRSGMDKQLIPVAESIDI                                        10        20        30       130       140       150       160       170       180 m247-1.pep  NYQNFFQVGSALIFQYGIDDVNASTATTVVSSCAAISKPGKQIPTLEDAKKELKIPDQDK   :| :|:| :||:|||||||::||: |:|||||: |:||||:| ||::||: |:| ::|| g247-1  KYPGFIQRLNALVFQYGIDDLDASAETVVVSSCSKIAKPGKKISTLQEAKSALQITNDDK          40        50        60        70        80        90       190       200       210       220       230       240 m247-1.pep  EQNGNIARQRHVVNAYAVGRIAD-EEGLFRFQLDDKGKWGNPQLLVKKVRHMKVRYIYVS   |||||:||:||||||||||::: ||:||||||||||||||||||||||::| ||||||| g247-1  -QNGNITRQKHVVNAYAVGRFGNNEESLFRFQLDDKGKWGNPQLLVKKVKRMDVRYIYVS          100       110       120       130       140        250       260       270       280       290       300 m247-1.pep  GCPEDDDAGKEETFKYTDKFDSAQNAVTPAGVEVLLSSGTDTKIAASSDNHIYAYRIDAT  |||||:|||||| |:||:|||:::||||||||||||:|| ::|||||||| ||||||:|| g247-1  GCPEDEDAGKEEKFRYTNKFDKSKNAVTPAGVEVLLDSGLNAKIAASSDNSIYAYRINAT150       160       170       180       190       200         310m247-1.pep   IRGGNVCANRTLX   ||||||||||||| g247-1   IRGGNVCANRTLX210       220The following partial DNA sequence was identified in N. meningitidis<SEQ ID 957>:

a247-1.seq (partial) 1AATAATACAG CTAAATTGAT TCCTATTGCT GAATCCACAG ATATTAAATA 51TCCGGGTTTT GCCCAGGCTC GTCCGGCATT GATTTTCCAA TACGGCATCG 101ATGATCTTGA TGCGAGTGCT GAGACTGTTG TAGTCAGCAG CTGTTCCAAA 151ATAGCAAAAC CGGGTAAGAA AATATCTACC TTGCAAGAAG CAAAGAGTGC 201ATTACAGATT ACTAATGATG ATAAACAAAA TGGAAATATC ACCCGTCAAA 251GGCATGTGGT CAATGCCTAT GCGGTCGGCA GGATTGCCGG TGAGGAAGGT 301TTGTTCCGCT TCCAATTGGA TGATAAGGGC AAGTGGGGTA ATCCTCAGTT 351GCTCGTGAAA AAGATTAGAC ATATGAAAGT GCGGTATATC TATGTTTCCG 401ACTGTCCTGA AGATGACGAT GCCGGCAAAG AGGAAAAATT CAAATATACG 451GGTACATTCG ACAGCTCCAC AAATGCTGTT ACGCCCGCCG GGGTGGAGGT 501TTTATTGAGT AGCGGTACTG ATACCAAGAT TGCCGCTTCT TCAGACAATC 551ATATTTATGC TTACCGTATC GATGCGACAA TACGCGGGGG AAATGTATGC 601GCAAACAGAA CACTTTGAThis corresponds to the amino acid sequence <SEQ ID 958; ORF 247-1.a>:

a247-1.pep (partial) .. 1NNTAKLIPIA ESTDIKYPGF AQARPALIFQ YGIDDLDASA ETVVVSSCSK 51IAKPGKKIST LQEAKSALQI TNDDKQNGNI TRQRHVVNAY AVGRIAGEEG 101LFRFQLDDKG KWGNPQLLVK KIRHMKVRYI YVSDCPEDDD AGKEEKFKYT 151GTFDSSTNAV TPAGVEVLLS SGTDTKIAAS SDNHIYAYRI DATIRGGNVC 201 ANRTL*m247-1/a247-1 80.6% identity in 206 aa overlap                                        10        20        30a247-1.pep                                NNTAKLIPIAESTDIKYPGFAQARPALIFQ                                |:  ||||||||::|:| :| |:  ||||| m247-1  GFGCFNMSEHPATDVIPDTTQQNSPFSLKRNGIDKLIPIAESSNINYQNFFQVGSALIFQ   80        90       100       110       120       130          40        50        60        70        80       89 a247-1.pep  YGIDDLDASAETVVVSSCSKIAKPGKKISTLQEAKSALQITNDDK-QNGNITRQRHVVNA  |||||::||: |:|||||: |:||||:| ||::||: |:| ::|| |||||:|||||||| m247-1  YGIDDVNASTATTVVSSCAAISKPGKQIPTLEDAKKELKIPDQDKEQNGNIARQRHVVNA  140       150       160       170       180       190 90       100       110       120       130       140      149a247-1.pep  YAVGRIAGEEGLFRFQLDDKGKWGNPQLLVKKIRHMKVRYIYVSDCPEDDDAGKEEKFKY   |||||||||||||||||||||||||||||||:||||||||||| ||||||||||| ||| m247-1  YAVGRIADEEGLFRFQLDDKGKWGNPQLLVKKVRHMKVRYIYVSGCPEDDDAGKEETFKY  200       210       220       230       240       250150       160       170       180       190       200 a247-1.pep  TGTFDSSTNAVTPAGVEVLLSSGTDTKIAASSDNHIYAYRIDATIRGGNVCANRTLX   | |||: ||||||||||||||||||||||||||||||||||||||||||||||||| m247-1  TDKFDSAQNAVTPAGVEVLLSSGTDTKIAASSDNHIYAYRIDATIRGGNVCANRTLX  260       270       280       290       300       310The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 959>:

g248.seq 1 atgcgcaaac agaacacttt gacaggaatc ccgacttctg acggacagag 51ggggtccgca ctgtttatcg tgctgatggt gatgatagtc gtggcctttt 101tggttgtaac tgccgcccag tcctacaata ccgaacagag gatcagtgcc 151aacgaatcag acaggaaatt ggctttgtct ttagccgagg cggctttgcg 201ggagggcgaa tttcaggttt tggatttgga atatgctgcg gacagtaagg 251ttacgtttag cgaaaactgt gaaaaaggtc tgtgtaccgc agtgaatgtg 301cggacaaata ataatggtag tgaagaggct tttggcaata tcgtggtgca 351aggcaagccc gccgttgagg cggtgaaacg ttcttgccct gcaaagtctg 401gcaaaaattc taccgacctg tgcattgaca ataaagggat ggaatataat 451aaaggcgcgg caggcgtcag caaaatgccg cgctatatta tcgaatattt 501aggcgtgaag aacggacaaa atgtttatcg ggttactgcc aaggcttggg 551gtaagaatgc caataccgtg gtcgtccttc aatcttatgt aggcaataat 601 gatgagcaat aaThis corresponds to the amino acid sequence <SEQ ID 960; ORF 248.ng>:

g248.pep 1 MRKQNTLTGI PTSDGQRGSA LFIVLMVMIV VAFLVVTAAQ SYNTEQRISA 51NESDRKLALS LAEAALREGE FQVLDLEYAA DSKVTFSENC EKGLCTAVNV 101RTNNNGSEEA FGNIVVQGKP AVEAVKRSCP AKSGKNSTDL CIDNKGMEYN 151KGAAGVSKMP RYIIEYLGVK NGQNVYRVTA KAWGKNANTV VVLQSYVGNN 201 DEQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 961>:

m248.seq (partial) 1..GGGTTTGCAC TGTTAATCGT GCTGATGGTG ATrATCGTCG TGGCT.TywT 51  gGwTGTAACT GCCGCGCAGT CTTACAATAC cGAGCAGCGk ATCAGTkCCA 101  ACGAATCAGA CAGGAAATTG GCTwTGTCTT TGGCCGAGkC GkCTwTGCGG 151  GAAGGCGAAC TTCAGGTTTT GGATTTGGAA TATGATACGG ACAGTAAGGT 201  TACATTTAGC GAAAACTGTG GAAAAGGTCT GTsTGCCGCA GTGAATGTGC 251  GGACAAATAA TGATAATGAA GAGGCTTTTG ACAATATCGT GGTGCAAGGC 301  AAGCCCACCG TTGAGGCGGT GAAGCGTTCT TGCCCTGCAA ATTCTACCGA 351  CCTGTGCATT GACAAGAAAG GGwTGGAATA TAAGAAAGGC ACGAGAAGCG 401  TCAc.AAAAT GCCACGTTAT ATTATCGAAT ATTTGGGCGT GwAGAACGGA 451  GAAAATGTTT ATCGGGTTAC TGCCAAGGCT TGGGGtAAGA ATGCCAATAC 501  CGTGGTCGTC CTTCAATCTT ATGTAAGCAA TAATGATGAG TAAThis corresponds to the amino acid sequence <SEQ ID 962; ORF 248>:

m248.pep (partial) 1..GFALLIVLMV XIVVAFXXVT AAQSYNTEQR ISXNESDRKL AXSLAEXXXR 51  EGELQVLDLE YDTDSKVTFS ENCGKGLXAA VNVRTNNDNE EAFDNIVVQG 101  KPTVEAVKRS CPANSTDLCI DKKGXEYKKG TRSVTKMPRY IIEYLGVXNG 151  ENVYRVTAKA WGKNANTVVV LQSYVSNNDE *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 248 shows 81.1% identity over a 185 aa overlap with a predicted ORF(ORF 248.ng) from N. gonorrhoeae:

m248/g248                           10        20        30        40m248.pep                   GFALLIVLMVXIVVAFXXVTAAQSYNTEQRISXNESDRKLAXS                  | ||:||||| |||||  |||||||||||||| |||||||| | g248 MRKQNTLTGIPTSDGQRGSALFIVLMVMIVVAFLVVTAAQSYNTEQRISANESDRKLALS         10        20        30        40        50        60      50        60        70        80        90       100 m248.pep LAEXXXREGELQVLDLEYDTDSKVTFSENCGKGLXAAVNVRTNND-NEEAFDNIVVQGKP  |||  ||||:||||||| :|||||||||| ||| :||||||||: :|||| |||||||| g248 LAEAALREGEFQVLDLEYAADSKVTFSENCEKGLCTAVNVRTNNNGSEEAFGNIVVQGKP         70        80        90       100       110       120      110           120       130       140       150 m248.pep TVEAVKRSCPA----NSTDLCIDKKGXEYKKGTRSVTKMPRYIIEYLGVXNGENVYRVTA :||||||||||    ||||||||:|| ||:||: :|:|||||||||||| ||:||||||| g248 AVEAVKRSCPAKSGKNSTDLCIDNKGMEYNKGAAGVSKMPRYIIEYLGVKNGQNVYRVTA        130       140       150       160       170       180160       170       180 m248.pep  KAWGKNANTVVVLQSYVSNNDEX |||||||||||||||||:|||| g248  KAWGKNANTVVVLQSYVGNNDEQX        190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 963>:

a248.seq 1 ATGCGCAAAC AGAACACTTT GACGGGAATC CCGACTTCTG ACGGACAGAG 51GGGGTTTGCA CTGTTTATCG TGCTGATGGT GATGATCGTC GTGGCTTTTT 101TGGTTGTAAC TGCCGCGCAG TCTTACAATA CCGAGCAGCG GATCAGTGCC 151AACGAATCAG ACAGGAAATT GGCTTTGTCT TTGGCCGAGG CGGCTTTGCG 201GGAAGGCGAA CTTCAGGTTT TGGATTTGGA ATATGATACG GACAGTAAGG 251TTACATTTAG CGAAAACTGT GGAAAAGGTC TGTGTACCGC AGTGAATGTG 301CGGACAAATA ATGATAATGA AGAGGCTTTT GACAATATCG TGGTGCAAGG 351CAAGCCCACC GTTGAGGCGG TGAAGCGTTC TTGCACTGCA AAATCTACAG 401GCCTGTGCAT TGACAATAAA GGGATGGAAT ATAAGAAAGG CACGCAAAGC 451GTCAGCAAAA TGCCACGTTA TATTATCGAA TATTTGGGCG TGAAGAACGG 501AGAAAATGTT TATCGGGTTA CTGCCAAGGC TTGGGGTAAG AATGCCAATA 551CCGTGGTCGT CCTTCAATCT TATGTAAGCA ATAATGATGA GTAAThis corresponds to the amino acid sequence <SEQ ID 964; ORF 248.a>:

a248.pep 1 MRKQNTLTGI PTSDGQRGFA LFIVLMVMIV VAFLVVTAAQ SYNTEQRISA 51NESDRKLALS LAEAALREGE LQVLDLEYDT DSKVTFSENC GKGLCTAVNV 101RTNNDNEEAF DNIVVQGKPT VEAVKRSCTA KSTGLCIDNK GMEYKKGTQS 151VSKMPRYIIE YLGVKNGENV YRVTAKAWGK NANTVVVLQS YVSNNDE*m248/a248 89.4% identity in 180 aa overlap

                         10        20        30        40 m248.pep                 GFALLIVLMVXIVVAFXXVTAAQSYNTEQRISXNESDRKLAXS                 ||||:||||| |||||  |||||||||||||| |||||||| | a248MRKQNTLTGIPTSDGQRGFALFIVLMVMIVVAFLVVTAAQSYNTEQRISANESDRKLALS        10        20        30        40        50        60     50        60        70        80        90       100 m248.pepLAEXXXREGELQVLDLEYDTDSKVTFSENCGKGLXAAVNVRTNNDNEEAFDNIVVQGKPT |||  |||||||||||||||||||||||||||| :|||||||||||||||||||||||| a248LAEAALREGELQVLDLEYDTDSKVTFSENCGKGLCTAVNVRTNNDNEEAFDNIVVQGKPT        70        80        90       100       110       120    110       120       130       140       150       160 m248.pepVEAVKRSCPANSTDLCIDKKGXEYKKGTRSVTKMPRYIIEYLGVXNGENVYRVTAKAWGK |||||||||:|| ||||:|| ||||||:||:|||||||||||| ||||||||||||||| a248VEAVKRSCTAKSTGLCIDNKGMEYKKGTQSVSKMPRYIIEYLGVKNGENVYRVTAKAWGK       130       140       150       160       170       180    170       180 m248.pep NANTVVVLQSYVSNNDEX |||||||||||||||||| a248NANTVVVLQSYVSNNDEX        190The following partial DNA sequence was identified in N. meningitidis<SEQ ID 965>:

m248-1.seq 1 ATGCGCAAAC AGAACACTTT GACGGGAATC CCGACTTCTG ACGGACAGAG 51GGGGTTTGCA CTGTTTATCG TGCTGATGGT GATGATCGTC GTGGCTTTTT 101TGGTTGTAAC TGCCGCGCAG TCTTACAATA CCGAGCAGCG GATCAGTGCC 151AACGAATCAG ACAGGAAATT GGCTTTGTCT TTGGCCGAGG CGGCTTTGCG 201GGAAGGCGAA CTTCAGGTTT TGGATTTGGA ATATGATACG GACAGTAAGG 251TTACATTTAG CGAAAACTGT GGAAAAGGTC TGTGTGCCGC AGTGAATGTG 301CGGACAAATA ATGATAATGA AGAGGCTTTT GACAATATCG TGGTGCAAGG 351CAAGCCCACC GTTGAGGCGG TGAAGCGTTC TTGCCCTGCA AATTCTACCG 401ACCTGTGCAT TGACAAGAAA GGGATGGAAT ATAAGAAAGG CACGAGAAGC 451GTCAGCAAAA TGCCACGTTA TATTATCGAA TATTTGGGCG TGAAGAACGG 501AGAAAATGTT TATCGGGTTA CTGCCAAGGC TTGGGGTAAG AATGCCAATA 551CCGTGGTCGT CCTTCAATCT TATGTAAGCA ATAATGATGA GTAAThis corresponds to the amino acid sequence <SEQ ID 966; ORF 248-1>:

m248-1.pep 1 MRKQNTLTGI PTSDGQRGFA LFIVLMVMIV VAFLVVTAAQ SYNTEQRISA 51NESDRKLALS LAEAALREGE LQVLDLEYDT DSKVTFSENC GKGLCAAVNV 101RTNNDNEEAF DNIVVQGKPT VEAVKRSCPA NSTDLCIDKK GMEYKKGTRS 151VSKMPRYIIE YLGVKNGENV YRVTAKAWGK NANTVVVLQS YVSNNDE* m248-1/g24889.1% identity in 202 aa overlap          10        20        30        40        50        60m248-1.pep  MRKQNTLTGIPTSDGQRGFALFIVLMVMIVVAFLVVTAAQSYNTEQRISANESDRKLALS  |||||||||||||||||| ||||||||||||||||||||||||||||||||||||||||| g248  MRKQNTLTGIPTSDGQRGSALFIVLMVMIVVAFLVVTAAQSYNTEQRISANESDRKLALS          10        20        30        40        50        60          70        80        90       100        110      119m248-1.pep  LAEAALREGELQVLDLEYDTDSKVTFSENCGKGLCAAVNVRTNND-NEEAFDNIVVQGKP  ||||||||||:||||||| :|||||||||| ||||:||||||||: :|||| |||||||| g248  LAEAALREGEFQVLDLEYAADSKVTFSENCEKGLCTAVNVRTNNNGSEEAFGNIVVQGKP          70        80        90       100       110       120120       130           140       150       160       170 m248-1.pep  TVEAVKRSCPA----NSTDLCIDKKGMEYKKGTRSVSKMPRYIIEYLGVKNGENVYRVTA  :||||||||||    ||||||||:|||||:||: :|||||||||||||||||:||||||| g248  AVEAVKRSCPAKSGKNSTDLCIDNKGMEYNKGAAGVSKMPRYIIEYLGVKNGQNVYRVTA         130       140       150       160       170       180    180       190 m248-1.pep   KAWGKNANTVVVLQSYVSNNDEX  |||||||||||||||||:|||| g248   KAWGKNANTVVVLQSYVGNNDEQX         190       200 m248-1/a248 97.0% identity in 197 aa overlap        10        20        30        40        50        60 m248-1.pepMRKQNTLTGIPTSDGQRGFALFIVLMVMIVVAFLVVTAAQSYNTEQRISANESDRKLALS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a248MRKQNTLTGIPTSDGQRGFALFIVLMVMIVVAFLVVTAAQSYNTEQRISANESDRKLALS        10        20        30        40        50        60        70        80        90       100       110       120 m248-1.pepLAEAALREGELQVLDLEYDTDSKVTFSENCGKGLCAAVNVRTNNDNEEAFDNIVVQGKPT|||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| a248LAEAALREGELQVLDLEYDTDSKVTFSENCGKGLCTAVNVRTNNDNEEAFDNIVVQGKPT        70        80        90       100       110       120       130       140       150       160       170       180 m248-1.pepVEAVKRSCPANSTDLCIDKKGMEYKKGTRSVSKMPRYIIEYLGVKNGENVYRVTAKAWGK |||||||||:|| ||||:|||||||||:||||||||||||||||||||||||||||||| a248VEAVKRSCTAKSTGLCIDNKGMEYKKGTQSVSKMPRYIIEYLGVKNGENVYRVTAKAWGK       130       140       150       160       170       180        190m248-1.pep NANTVVVLQSYVSNNDEX |||||||||||||||||| a248 NANTVVVLQSYVSNNDEX       190The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 967>:

g249.seq 1 atgaagaata atgattgctt gcgcctgaaa aatccccagt ccggtatggc 51gttgatagaa gtcttggtcg ctatgctcgt tctgaccatc ggtattttgg 101cattgctgtc cgtacagttg cggacagtcg cttccgtcag ggaggcggaa 151acgcaaacca tcgtcagcca aatcacgcaa aacctgatgg aaggaatgtt 201gatgaatccg accattgatt tggacagcaa caagaaaaac tatagtcttt 251acatgggaaa acagacacta tcagctgtgg atggtgagtt tatgcttgat 301gccgagaaaa gtaaggcgca gttggcagag gaacaattga agagatttag 351tcatgagctg aaaaatgcct tgccggatgc ggtagctatt cattacgccg 401tctgcaagga ttcgtcgggt gacgcgccga cattgtccga cagcggtgct 451ttttcttcaa attgcgacaa taaggcaaac ggggatactt tgattaaagt 501attgtgggta aatgattcgg caggggattc ggatatttcc cgtacgaatc 551ttgaagtgag cggcgacaat atcgtatata cctatcaggc aagggtcgga 601 ggtcgtgaat gaThis corresponds to the amino acid sequence <SEQ ID 968; ORF 249.ng>:

g249.pep 1 MKNNDCLRLK NPQSGMALIE VLVAMLVLTI GILALLSVQL RTVASVREAE 51TQTIVSQITQ NLMEGMLMNP TIDLDSNKKN YSLYMGKQTL SAVDGEFMLD 101AEKSKAQLAE EQLKRFSHEL KNALPDAVAI HYAVCKDSSG DAPTLSDSGA 151FSSNCDNKAN GDTLIKVLWV NDSAGDSDIS RTNLEVSGDN IVYTYQARVG 201 GRE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 969>:

m249.seq 1 ATGAAGAATA ATGATTGCTT CCGCCTGAAA GATTCCCAGT CCGGTATGGC 51GCTGATAGAA GTCTTGGTTG CTATGCTCGT TCTGACCATC GGTATTTTGG 101 CACTATTGTCTGTACAGTTG CGGACAGTCN NNNNNNNNNN NNNNNNNNNN 151 NNNNNNNNNN NNNNNNNNNNNNNNNNNNNN NNNTTGATGG AGGGAATGTT 201 GATGAATCCG ACCATTGATT CGGACAGCAACAAGAAAAAC TATAATCTTT 251 ACATGGGAAA CCATACACTA TCAGCTGTGG ATGGCGATTTTGCGATTGAT 301 GCCATGAAAA CTAAGGGGCA ATTGGCAGAG GCACAATTGA AGAGATTTAG351 TTATGAGCTG AAAAATGCCT TGCCGGATGC GGCAGCCATC CATTACGCCG 401TCTGCAAGGA TTCGTCGGGT AACGCGCCGA CATTGTCCGG CAATGCTTTT 451 TCTTCAAATTGCGACAATAA GGCAAACGGG GATACTTTAA TTAAAGTATT 501 GTGGGTAAAT GATTCGGCAGGGGATTCGGA TATTTCCCGT ACGAATCTTG 551 AGGTGAGCGG CGACAATATC GTATATACTTATCAGGCAAG GGTCGGAGGT 601 CGGGAATGAThis corresponds to the amino acid sequence <SEQ ID 970; ORF 249>:

m249.pep 1 MKNNDCFRLK DSQSGMALIE VLVAMLVLTI GILALLSVQL RTVXXXXXXX 51XXXXXXXXXX XLMEGMLMNP TIDSDSNKKN YNLYMGNHTL SAVDGDFAID 101 AMKTKGQLAEAQLKRFSYEL KNALPDAAAI HYAVCKDSSG NAPTLSGNAF 151 SSNCDNKANG DTLIKVLWVNDSAGDSDISR TNLEVSGDNI VYTYQARVGG 201 RE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 249 shows 81.3% identity over a 203 aa overlap with a predicted ORF(ORF 249.ng) from N. gonorrhoeae:

m249/g249           10        20        30        40        50        60m249.pep   MKNNDCFRLKDSQSGMALIEVLVAMLVLTIGILALLSVQLRTVXXXXXXXXXXXXXXXXX  ||||||:|||: |||||||||||||||||||||||||||||||       : :     : g249  MKNNDCLRLKNPQSGMALIEVLVAMLVLTIGILALLSVQLRTVASVREAETQTIVSQITQ          10        20        30        40        50        60          70        80        90       100       110       120 m249.pep  XLMEGMLMNPTIDSDSNKKNYNLYMGNHTLSAVDGDFAIDAMKTKGQLAEAQLKRFSYEL   |||||||||||| |||||||:||||::|||||||:| :|| |:|:|||| ||||||:|| g249  NLMEGMLMNPTIDLDSNKKNYSLYMGKQTLSAVDGEFMLDAEKSKAQLAEEQLKRFSHEL          70        80        90       100       110       120         130       140        150       160       170      179 m249.pep  KNALPDAAAIHYAVCKDSSGNAPTLSGN-AFSSNCDNKANGDTLIKVLWVNDSAGDSDIS  |||||||:||||||||||||:||||| : ||||||||||||||||||||||||||||||| g249  KNALPDAVAIHYAVCKDSSGDAPTLSDSGAFSSNCDNKANGDTLIKVLWVNDSAGDSDIS         130       140       150       160       170       180180       190       200 m249.pep   RTNLEVSGDNIVYTYQARVGGREX  |||||||||||||||||||||||| g249   RTNLEVSGDNIVYTYQARVGGREX         190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 971>:

a249.seq 1 ATGAAGAATA ATGATTGCTT CCGCCTGAAA AACCCCCAGT CCGGTATGGC 51GCTGATAGAA GTCTTGGTCG CTATGCTCGT TCTGACCATC GGTATTTTGG 101 CACTATTGTCTGTTCAGTTG CGGACAGTCG CTTCCGTCAG GGAGGCAGAG 151 ACGCAAACCA TCGTCAGTCAAATCACGCAA AACCTGATGG AAGGAATGTT 201 GATGAATCCG ACCATTGATT CGGACAGCAACAAGAAAAAC TATAATCTTT 251 ACATGGGAAA CCATCATGCA CTATCAGTTG TGGATGGCGATTTTCAGGTT 301 GATGCCATAA AAACTAAGAC GCAGTTGGCA GAGGCACAAT TGAAGAGATT351 TAGTTATGAG CTGAAAAATG CCTTGCCGGA TGCGGCAGCC ATCCATTACG 401CCGTCTGCAA GGATTCGTCG GGTGTTGCGC CGACATTGTC CGCCGGCAGT 451 ACTTTTTCTTCAAATTGCGA TGGTAGTGCA AATGGGGATA CTTTGATTAA 501 AGTATTGTGG GTAAATGATTCGGCAGGGGA TTCGGATATC GCCCGTACGA 551 ATCTTGAGAC GAACGGCAAC AATATCGTATATACCTATCA GGCAAGGGTC 601 GGAGGTCGGG AATGAThis corresponds to the amino acid sequence <SEQ ID 972; ORF 249.a>:

a249.pep 1 MKNNDCFRLK NPQSGMALIE VLVAMLVLTI GILALLSVQL RTVASVREAE 51TQTIVSQITQ NLMEGMLMNP TIDSDSNKKN YNLYMGNHHA LSVVDGDFQV 101 DAIKTKTQLAEAQLKRFSYE LKNALPDAAA IHYAVCKDSS GVAPTLSAGS 151 TFSSNCDGSA NGDTLIKVLWVNDSAGDSDI ARTNLETNGN NIVYTYQARV 201 GGRE* m249/a249 81.9% identity in204 aa overlap          10        20        30        40        50        60 m249.pep  MKNNDCFRLKDSQSGMALIEVLVAMLVLTIGILALLSVQLRTVXXXXXXXXXXXXXXXXX  ||||||||||: |||||||||||||||||||||||||||||||       : :     : a249  MKNNDCFRLKNPQSGMALIEVLVAMLVLTIGILALLSVQLRTVASVREAETQTIVSQITQ          10        20        30        40        50        60          70        80         90       100       110      119 m249.pep  XLMEGMLMNPTIDSDSNKKNYNLYMGNH-TLSAVDGDFAIDAMKTKGQLAEAQLKRFSYE   ||||||||||||||||||||||||||| :||:||||| :||:||| ||||||||||||| a249  NLMEGMLMNPTIDSDSNKKNYNLYMGNHHALSVVDGDFQVDAIKTKTQLAEAQLKRFSYE          70        80        90       100       110       120120       130       140        150       160       170 m249.pep  LKNALPDAAAIHYAVCKDSSGNAPTLS-GNAFSSNCDNKANGDTLIKVLWVNDSAGDSDI  ||||||||||||||||||||| ||||| |::||||||::||||||||||||||||||||| a249  LKNALPDAAAIHYAVCKDSSGVAPTLSAGSTFSSNCDGSANGDTLIKVLWVNDSAGDSDI         130       140       150       160       170       180 180       190       200 m249.pep   SRTNLEVSGDNIVYTYQARVGGREX  :|||||::|:||||||||||||||| a249   ARTNLETNGNNIVYTYQARVGGREX         190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 973>:

m249-1.seq 1 ATGAAGAATA ATGATTGCTT CCGCCTGAAA GATTCCCAGT CCGGTATGGC 51GCTGATAGAA GTCTTGGTTG CTATGCTCGT TCTGACCATC GGTATTTTGG 101 CACTATTGTCTGTACAGTTG CGGACAGTCG CTTCCGTCAG GGAGGCGGAG 151 ACACAAACCA TCGTCAGCCAAATCACGCAA AACCTGATGG AGGGAATGTT 201 GATGAATCCG ACCATTGATT CGGACAGCAACAAGAAAAAC TATAATCTTT 251 ACATGGGAAA CCATACACTA TCAGCTGTGG ATGGCGATTTTGCGATTGAT 301 GCCATGAAAA CTAAGGGGCA ATTGGCAGAG GCACAATTGA AGAGATTTAG351 TTATGAGCTG AAAAATGCCT TGCCGGATGC GGCAGCCATC CATTACGCCG 401TCTGCAAGGA TTCGTCGGGT AACGCGCCGA CATTGTCCGG CAATGCTTTT 451 TCTTCAAATTGCGACAATAA GGCAAACGGG GATACTTTAA TTAAAGTATT 501 GTGGGTAAAT GATTCGGCAGGGGATTCGGA TATTTCCCGT ACGAATCTTG 551 AGGTGAGCGG CGACAATATC GTATATACTTATCAGGCAAG GGTCGGAGGT 601 CGGGAATGAThis corresponds to the amino acid sequence <SEQ ID 974; ORF 249-1>:

m249-1.pep 1 MKNNDCFRLK DSQSGMALIE VLVAMLVLTI GILALLSVQL RTVASVREAE 51TQTIVSQITQ NLMEGMLMNP TIDSDSNKKN YNLYMGNHTL SAVDGDFAID 101 AMKTKGQLAEAQLKRFSYEL KNALPDAAAI HYAVCKDSSG NAPTLSGNAF 151 SSNCDNKANG DTLIKVLWVNDSAGDSDISR TNLEVSGDNI VYTYQARVGG 201 RE* m249-1/g249 90.1% identity in203 aa overlap          10        20        30        40        50        60m249-1.pep  MKNNDCFRLKDSQSGMALIEVLVAMLVLTIGILALLSVQLRTVASVREAETQTIVSQITQ  ||||||:|||: |||||||||||||||||||||||||||||||||||||||||||||||| g249  MKNNDCLRLKNPQSGMALIEVLVAMLVLTIGILALLSVQLRTVASVREAETQTIVSQITQ          10        20        30        40        50        60          70        80        90       100       110       120m249-1.pep  NLMEGMLMNPTIDSDSNKKNYNLYMGNHTLSAVDGDFAIDAMKTKGQLAEAQLKRFSYEL  ||||||||||||| |||||||:||||::|||||||:| :|| |:|:|||| ||||||:|| g249  NLMEGMLMNPTIDLDSNKKNYSLYMGKQTLSAVDGEFMLDAEKSKAQLAEEQLKRFSHEL          70        80        90       100       110       120         130       140        150       160       170      179m249-1.pep  KNALPDAAAIHYAVCKDSSGNAPTLSGN-AFSSNCDNKANGDTLIKVLWVNDSAGDSDIS  |||||||:||||||||||||:||||| : ||||||||||||||||||||||||||||||| g249  KNALPDAVAIHYAVCKDSSGDAPTLSDSGAFSSNCDNKANGDTLIKVLWVNDSAGDSDIS         130       140       150       160       170       180180       190       200 m249-1.pep   RTNLEVSGDNIVYTYQARVGGREX  |||||||||||||||||||||||| g249   RTNLEVSGDNIVYTYQARVGGREX         190       200 a249/L36117 gi|643582 (L36117) prepilin leadersequence requires cleavage to be active [Pseudomonasaeruginosa] >gi|1161222 (L48934) involved in type 4 fimbrial biogenesis;contains pre-pilin like leader sequence [Pseudomonasaeruginosa] >gi|1246299 (L76605) reference L36117, L48934 [Pseudomonasaeruginosa] Length = 185 Score = 50.4 bits (118), Expect = 9e−06Identities = 45/183 (24%), Positives = 84/183 (45%), Gaps = 26/183 (14%)Query: 13 QSGMALIEVLVAMLVLTIGILALLSVQLRTVASVREAETQTIVSQITQNLMEGMLMNPTI72 QSG ++IEVLVA+L+++IG+L ++++Q +T+    ++  +   + +  NL+E M  +P Sbjct: 12QSGFSMIEVLVALLLISIGVLGMIAMQGKTIQYTADSVERNKAAMLGSNLLESMRASPKA 71 Query:73 DSDSNKKNYNLYMGNHHALSVVDGDFQVDAIKTKTQLAEA---QLKRFSYELKNALPDAA 129  D   +     M          G     A  + T L +A   +L  ++ ++KN LP A Sbjct: 72LYDVKDQ-----MATQSDFFKAKGSAFPTAPSSCTPLPDAIKDRLGCWAEQVKNELPGAG 126 Query:130 AI---HYAVCKDSSGVAPTLSAGSTFSSNCDGSANGDTL-IKVLWVNDSAGDSDIARTNL 185 +    Y +C+ S               +CDG   G  L I++ W        + A ++ Sbjct: 127DLLKSDYYICRSSK------------PGDCDG--KGSMLEIRLAWRGKQGACVNAADSSA 172 Query:186 ETN 188 +T+ Sbjct: 173 DTS 175 m249-1/a249 90.7% identity in 204 aaoverlap           10        20        30        40        50        60m249-1.pep  MKNNDCFRLKDSQSGMALIEVLVAMLVLTIGILALLSVQLRTVASVREAETQTIVSQITQ  ||||||||||: |||||||||||||||||||||||||||||||||||||||||||||||| a249  MKNNDCFRLKNPQSGMALIEVLVAMLVLTIGILALLSVQLRTVASVREAETQTIVSQITQ          10        20        30        40        50        60          70        80         90       100       110      119m249-1.pep  NLMEGMLMNPTIDSDSNKKNYNLYMGNH-TLSAVDGDFAIDAMKTKGQLAEAQLKRFSYE  |||||||||||||||||||||||||||| :||:||||| :||:||| ||||||||||||| a249  NLMEGMLMNPTIDSDSNKKNYNLYMGNHHALSVVDGDFQVDAIKTKTQLAEAQLKRFSYE          70        80        90       100       110       120120       130       140       150       160       170 m249-1.pep  LKNALPDAAAIHYAVCKDSSGNAPTLS-GNAFSSNCDNKANGDTLIKVLWVNDSAGDSDI  ||||||||||||||||||||| ||||| |::||||||::||||||||||||||||||||| a249  LKNALPDAAAIHYAVCKDSSGVAPTLSAGSTFSSNCDGSANGDTLIKVLWVNDSAGDSDI         130       140       150       160       170       180 180       190       200 m249-1.pep   SRTNLEVSGDNIVYTYQARVGGREX  :|||||::|:||||||||||||||| a249   ARTNLETNGNNIVYTYQARVGGREX         190       200The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 975>:

g250.seq 1 atgacgcaca cagcctctcc acgtgatgaa ttcatacgcg gcataaaaga 51aagttcgccc atgctgattg ggcttttgcc ttgggcattg atactcggta 101 tgcagggcgggcaaaaaggt atgggccggc tggaaatgct gctgatgacg 151 gggatgaact ttgccggcggctccgaattt gccacggtca acctgtgggc 201 ggaacctctg ccgatactgc ttatcgccaccataaccttt atgattaatt 251 cgcggcatat cctgatgggg ggcggcgctt gccacgcacatgaaagaaat 301 accgctgaaa aaagccgcgc ccgcgctgtt ttttatgtgt gaThis corresponds to the amino acid sequence <SEQ ID 976; ORF 250.ng>:

g250.pep 1 MTHTASPRDE FIRGIKESSP MLIGLLPWAL ILGMQGGQKG MGRLEMLLMT 51GMNFAGGSEF ATVNLWAEPL PILLIATITF MINSRHILMG GGACHAHERN 101 TAEKSRARAVFYV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 977>:

m250.seq 1 ATGCACACCT TCCCCGCATA ACGAATTTAT ACGCGGCATC AAAGAAAGTT 51CGCCTATGCT GATTGGGCTG CTGCCTTGGG CATTAATACT CGGTATGCAG 101 GGCGGACAAAAAGGCATGAG CTGGCTGGAA ATGTTGTTGA TGACCAGTAT 151 GAACTTCGCC GGCGGCTCCGAGTTTGCCAC GGTCAACCTG TGGGCsGAAC 201 CTCTGCCGAT ACTGCTTATC GCCACCGTAACCTTTATGAT TAATTCTCGG 251 CATATCCTGA T.GGGGGCGG CGCTTGCCCC GCACCTGAAAGGAaTACCGC 301 TGAAAAAAGC CGTGCCCGCA CTGTTTTTTA TGTGTGAThis corresponds to the amino acid sequence <SEQ ID 978; ORF 250>:

m250.pep 1 MHTPSPHNEF IRGIKESSPM LIGLLPWALI LGMQGGQKGM SWLEMLLMTS 51MNFAGGSEFA TVNLWAEPLP ILLIATVTFM INSRHILMGG GACPAPERNT 101 AEKSRARTVFYV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 250 shows 91.0% identity over a 111 aa overlap with a predicted ORF(ORF 250.ng) from N. gonorrhoeae:

m250/g250           10        20        30        40        50       59m250.pep   MHTPSPHNEFIRGIKESSPMLIGLLPWALILGMQGGQKGMSWLEMLLMTSMNFAGGSEF   || ||::||||||||||||||||||||||||||||||||: |||||||:||||||||| g250 MTHTASPRDEFIRGIKESSPMLIGLLPWALILGMQGGQKGMGRLEMLLMTGMNFAGGSEF         10        20        30        40        50        6060        70        80        90       100       110 m250.pep ATVNLWAEPLPILLIATVTFMINSRHILMGGGACPAPERNTAEKSRARTVFYVX |||||||||||||||||:|||||||||||||||| | |||||||||||:|||| g250 ATVNLWAEPLPILLIATITFMINSRHILMGGGACHAHERNTAEKSRARAVFYV         70        80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 979>:

a250.seq 1 ATGACACACA TAAGCTCGCC CCGTAACGAA TTTATACGCG GCATCAAAGA 51AAGTTCGCCC ATGCTGATCG GGCTTTTGCC TTGGGCATTA ATACTCGGTA 101 TGCAGGGTGGACAAAAAGGC ATGAGCTGGC TGGAAATGTT GTTGATGACC 151 GGTATGAACT TCGCCGGCGGCTCCGAGTTT GCCACGGTCA ACCTGTGGGC 201 GGAACCTCTG CCGATACTGC TTATCGCCACCGTAACCTTT ATGATTAATT 251 CTCGGCATAT CCTGATGGGG G.CGGCACTT GCCCCGCACCTGAAAGAAAT 301 ACCGCTGAAA AAAGCCGTGC CCGCACTGTT TTTTATGTGT GAThis corresponds to the amino acid sequence <SEQ ID 980; ORF 250.a>:

a250.pep 1 MTHISSPRNE FIRGIKESSP MLIGLLPWAL ILGMQGGQKG MSWLEMLLMT 51GMNFAGGSEF ATVNLWAEPL PILLIATVTF MINSRHILMG XGTCPAPERN 101 TAEKSRARTVFYV* m250/a250 94.6% identity in 111 aa overlap          10        20        30        40        50       59 m250.pep  MHTPSPHNEFIRGIKESSPMLIGLLPWALILGMQGGQKGMSWLEMLLMTSMNFAGGSEF   |  ||:||||||||||||||||||||||||||||||||||||||||||:||||||||| a250 MTHISSPRNEFIRGIKESSPMLIGLLPWALILGMQGGQKGMSWLEMLLMTGMNFAGGSEF         10        20        30        40        50        6060        70        80        90       100       110 m250.pep ATVNLWAEPLPILLIATVTFMINSRHILMGGGACPAPERNTAEKSRARTVFYVX |||||||||||||||||||||||||||||| |:||||||||||||||||||||| a250 ATVNLWAEPLPILLIATVTFMINSRHILMGXGTCPAPERNTAEKSRARTVFYVX         70        80        90       100       110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 981>:

g251.seq 1 atgcctgacc caatagggat tcttttcgct gccgtcgggg ttgatttttt 51tgccgttgtt ttgagggggc gttttcaacg aataggcgcg gttggcatgt 101 tgataataataatcctgatg gcggaggtcg gaaccaaaac ggtcgtaacc 151 gaggttgacg ctcaggttgtggcggatttt ggcggtatcg aaggattttt 201 tgaatgccgc ctgcaagagc ctgtggctttccccgtaaat cacgcggtcg 251 gatttgtagt aggaagacgg cttgtcggca ctcgggcggcaatatttgtc 301 cgaaccgtcg gcggaacagt gcgtctgctg aaaatgattg tccaaaccga351 tgccctgccg gtcgtaagag aggcgggcat aatccgccca agtgtcttta 401tcggcattgg tatagacata ttccaaaccg tagcggcttt tggtgtgcgt 451 ctcgtcgtaaaacacgcccg taccgtattc cgcgcccacc tccgcaccgt 501 tttcaccgtt ggtaatcagcccgctgtatt tgcggccgcc cgcgtatttg 551 ccgtagcctc ttatcgatcc gtattttttattttcatcaa aaaccgcctt 601 ggtcaggaat gccggaaccg tcatatcgcg cgtgtcgaaagtttgctgcg 651 tgcgttcgag tatgccgccg atgtagtgcc gtttgttttc aaaacgaaaa701 cccgggcgga acagccacga ccggctttcg tatgaThis corresponds to the amino acid sequence <SEQ ID 982; ORF 251.ng>:

g251.pep 1 MPDPIGILFA AVGVDFFAVV LRGRFQRIGA VGMLIIIILM AEVGTKTVVT 51EVDAQVVADF GGIEGFFECR LQEPVAFPVN HAVGFVVGRR LVGTRAAIFV 101 RTVGGTVRLLKMIVQTDALP VVREAGIIRP SVFIGIGIDI FQTVAAFGVR 151 LVVKHARTVF RAHLRTVFTVGNQPAVFAAA RVFAVASYRS VFFIFIKNRL 201 GQECRNRHIA RVESLLRAFE YAADVVPFVFKTKTRAEQPR PAFV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 983>:

m251.seq 1 ATGCGTGCTG CGGTAGTCGT AGCGCAAGCC CGCGCCGACA TCCGCCCACC 51TGCCCAAACG GACATTGTCC CGAACTGCCG CGTAATAGCT TTTACCGTTG 101 ATGCTGCGCGGCGTGCAGTC CGTATAAGTA TTGTTGCCCA AGCGGCAGAT 151 TTGCCCCGTA ACGACATTTCCCCTGCCTAT GGTGACCCAA TAGGGGCTGG 201 TTTCACTGCC GTTGGGGCTG ATTTTTTTGCCGTTGTTTTG AGGGGGCGTG 251 TTCGACGAAT AGGCGCGGTT GGCATGTTGA TAATAATAATCCTGATGGCG 301 GAGATTAGAG CCAAAGCGGT CAAACCCGAG ATTCACGCTC AGGTTGTGGC351 GGATTTTGGC GGTATCGAAG GATTTTTTGA ATGCCGCCTG CAAGAGCCTG 401TGGCTTTCCC CGTAAATCAC GCGATCGGAT TTGTAATAGG AAAACGGCTT 451 GTCGGCACTCGGGCGGCAAT ATTTGTCCGA ACCGTCGGCA GAACAGTGCG 501 TCTGCTGAAA ATGATTATCCAAACCGATGC CCTGCCGGTC GTAAGAGAGG 551 CGGGCATAAT CCGCCCAAGT GTCTTTATCGGCATTGGTAT AGACATATTC 601 CAAACCGTAG CGGCTTTTGG TGTGCGTCTC GTCGTAAAACACGCCCGTAC 651 CGTATTCCGC GCCCACCAGC GCACCGTTTT CGCCGTTGGT AAACAGTCCG701 CCGTATTTGT GGTTGCCCGC GTATTTGCCG TTACCGGGCA AAGAACCCGC 751CTGTTTTTTA TTTGCATCAA AAACCGCCTT GGTCAGGAAT GCCGGAACCG 801 TCATATCGCGCGTGTCGAAA GTTTGTTGCG TGTGTTCGAG TATGCCGCCG 851 ATGTAGTGCC GCTTATTCTCAAAACGAAAA CCCGGGCGGA ACAGCCACGA 901 CCGGCTTTCG TATGAThis corresponds to the amino acid sequence <SEQ ID 984; ORF 251>:

m251.pep 1 MRAAVVVAQA RADIRPPAQT DIVPNCRVIA FTVDAARRAV RISIVAQAAD 51LPRNDISPAY GDPIGAGFTA VGADFFAVVL RGRVRRIGAV GMLIIIILMA 101 EIRAKAVKPEIHAQVVADFG GIEGFFECRL QEPVAFPVNH AIGFVIGKRL 151 VGTRAAIFVR TVGRTVRLLKMIIQTDALPV VREAGIIRPS VFIGIGIDIF 201 QTVAAFGVRL VVKHARTVFR AHQRTVFAVGKQSAVFVVAR VFAVTGQRTR 251 LFFICIKNRL GQECRNRHIA RVESLLRVFE YAADVVPLILKTKTRAEQPR 301 PAFV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 251 shows 85.2% identity over a 243 aa overlap with a predicted ORF(ORF 251.ng) from N. gonorrhoeae:

m251/g251        40        50        60        70        80        90m251.pep TVDAARRAVRISIVAQAADLPRNDISPAYGDPIGAGFTAVGADFFAVVLRGRVRRIGAVG                              ||||  |:|||:|||||||||| :|||||| g251                            MPDPIGILFAAVGVDFFAVVLRGRFQRIGAVG                                    10        20        30      100       110       120       130       140       150 m251.pepMLIIIILMAEIRAKAVKPEIHAQVVADFGGIEGFFECRLQEPVAFPVNHAIGFVIGKRLV ||||||||||::|:|  |: |||||||||||||||||||||||||||||:|||:|:||| g251MLIIIILMAEVGTKTVVTEVDAQVVADFGGIEGFFECRLQEPVAFPVNHAVGFVVGRRLV      40        50        60        70        80        90      160       170       180       190       200       210 m251.pepGTRAAIFVRTVGRTVRLLKMIIQTDALPVVREAGIIRPSVFIGIGIDIFQTVAAFGVRLV|||||||||||| ||||||||:|||||||||||||||||||||||||||||||||||||| g251GTRAAIFVRTVGGTVRLLKMIVQTDALPVVREAGIIRPSVFIGIGIDIFQTVAAFGVRLV     100       110       120       130       140       150      220       230       240       250       260       270 m251.pepVKHARTVFRAHQRTVFAVGKQSAVFVVARVFAVTGQRTRLFFICIKNRLGQECRNRHIAR||||||||||| ||||:||:| |||::||||||:: |: :||| |||||||||||||||| g251VKHARTVFRAHLRTVFTVGNQPAVFAAARVFAVASYRS-VFFIFIKNRLGQECRNRHIAR     160       170       180       190        200       210      280       290       300 m251.pepVESLLRVFEYAADVVPLILKTKTRAEQPRPAFVX ||||||:|||||||||:::|||||||||||||||g251 VESLLRAFEYAADVVPFVFKTKTRAEQPRPAFVX       220       230       240The following partial DNA sequence was identified in N. meningitidis<SEQ ID 985>:

a251.seq 1 ATGCGTGCTG CGGTAGTCGT AGCGCAACCC CGCGCCGACA TCCGCCCACC 51TGCCCAAACG GACATTGTCC CGAACTGCCG CGTAATAGCT TTTGCCGTTG 101 ATGCTGCGCGGCGTGCAGTC CGTATAAGTA TTGTTGCCCA AGCGGCAGAT 151 TTGCCCCGTA ACCACATTTCCCCTGCCTAT GCTGACCCAA TAGGGTTGGT 201 CCTTGCCGCC GTTGGGGTTG GCGGTTTTAGGGGGCGTTTT CGACGAATAG 251 GCGCGGTTGG CATGTTGATA ATAATAATCC TGATGGCGGAGATTAGAGTC 301 AAAGCGGTCA AAACCGAGAT TCACGCTCAG GTTGTGGCGG ATTTTGGCGG351 TATCGAAGGA TTTTTTGAAT GCCGCCTGCA AGAGCCTGTG GCTTTCCCCG 401TAAATCACGC GGTCGGATTT GTAGTAGGAA AACGGCTTGT CGGCACTCGG 451 GCGGCAATATTTGTCCGAAC CGTCGGCAGA ACAGTGCGTC TGCTGAAAAT 501 GATTGTCCAA ACCGATGCCCTGCCGGTCGT AAGAGAGGCG GGCATAATCC 551 ACCCAAGTGT CTTTATCGGC ATTGGTATAGACATATTCCA AACCGTAGCG 601 GCTTTTGGTG TGCGTCTCGT CGTAAAACAC GCCCGTACCGTATTCCGCGC 651 CCACCAGCGC ACCGTTTTCG CCGTTGGTAA ACAGACCGCC GTATTTGTGG701 TCGCCCGCGT ATTTGCCGTT GCCTCTTATC GGTCCGTATT TTCTATTTTC 751ATCAAAAACC GCCTTGGTCA GGAATGCCGG AACCGTCATA TCGCGCGTGT 801 CGAAAGTTTGTTGCGTGTGT TCGAGTATGC CGCCGATGTA GTGCCGTTTG 851 TTTTCAAAAC GAAAACCCGGGCGGAACAGC CACGATCGGC TTTCGTATGAThis corresponds to the amino acid sequence <SEQ ID 986; ORF 251.a>:

a251.pep 1 MRAAVVVAQP RADIRPPAQT DIVPNCRVIA FAVDAARRAV RISIVAQAAD 51LPRNHISPAY ADPIGLVLAA VGVGGFRGRF RRIGAVGMLI IIILMAEIRV 101 KAVKTEIHAQVVADFGGIEG FFECRLQEPV AFPVNHAVGF VVGKRLVGTR 151 AAIFVRTVGR TVRLLKMIVQTDALPVVREA GIIHPSVFIG IGIDIFQTVA 201 AFGVRLVVKH ARTVFRAHQR TVFAVGKQTAVFVVARVFAV ASYRSVFSIF 251 IKNRLGQECR NRHIARVESL LRVFEYAADV VPFVFKTKTRAEQPRSAFV* m251/a251 88.5% identity in 304 aa overlap        10        20        30        40        50        60 m251.pepMRAAVVVAQARADIRPPAQTDIVPNCRVIAFTVDAARRAVRISIVAQAADLPRNDISPAY||||||||| |||||||||||||||||||||:|||||||||||||||||||||| ||||| a251MRAAVVVAQPRADIRPPAQTDIVPNCRVIAFAVDAARRAVRISIVAQAADLPRNHISPAY        10        20        30        40        50        60        70        80        90       100       110       120 m251.pepGDPIGAGFTAVGADFFAVVLRGRVRRIGAVGMLIIIILMAEIRAKAVKPEIHAQVVADFG:||||  ::|||:  |    ||| |||||||||||||||||||:|||| ||||||||||| a251ADPIGLVLAAVGVGGF----RGRFRRIGAVGMLIIIILMAEIRVKAVKTEIHAQVVADFG        70            80        90       100       110       130       140       150       160       170       180 m251.pepGIEGFFECRLQEPVAFPVNHAIGFVIGKRLVGTRAAIFVRTVGRTVRLLKMIIQTDALPV|||||||||||||||||||||:|||:||||||||||||||||||||||||||:||||||| a251GIEGFFECRLQEPVAFPVNHAVGFVVGKRLVGTRAAIFVRTVGRTVRLLKMIVQTDALPV 120       130       140       150       160       170       190       200       210       220       230       240 m251.pepVREAGIIRPSVFIGIGIDIFQTVAAFGVRLVVKHARTVFRAHQRTVFAVGKQSAVFVVAR|||||||:||||||||||||||||||||||||||||||||||||||||||||:||||||| a251VREAGIIHPSVFIGIGIDIFQTVAAFGVRLVVKHARTVFRAHQRTVFAVGKQTAVFVVAR 180       190       200       210       220       230       250       260       270       280       290       300 m251.pepVFAVTGQRTRLFFICIKNRLGQECRNRHIARVESLLRVFEYAADVVPLILKTKTRAEQPR ||||:: |::| | ||||||||||||||||||||||||||||||||:::|||||||||| a251VFAVASYRS-VFSIFIKNRLGQECRNRHIARVESLLRVFEYAADVVPFVFKTKTRAEQPR 240        250       260       270       280       290 m251.pep PAFVX |||| a251 SAFVX   300The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 987>:

g253.seq 1 atgatcgaca gggaccgtat gttgcgggac acgttggaac gtgtgcgtgc 51ggggtcgttc tggttatggg tggtggtggc atcgatgatg tttaccgccg 101 gattttcaggcacttatctt ctgatggaca atcaggggct gaatttcttt 151 ttagttttgg cgggagtgttgggcatgaat acgctgatgc tggcagtatg 201 gttggcaacg ttgttcctgc gcgtgaaagtgggacggttt ttcagcagtc 251 cggcgacgtg gtttcggggc aaaggccctg taaatcaggcggtgttgcgg 301 ctgtatgcgg accagtggcg gcaaccttcg gtacgatgga aaataggcgc351 aacggcgcac agcttgtggc tctgcacgct gctcggaatg ctggtgtcgg 401tattgctgct gcttttggtg cggcaatata cgttcaactg ggaaagcacg 451 ctgttgagcaatgccgcttc ggtacgcgcg gtggaaatgt tggcatggct 501 gccgtcgaaa ctcggtttccctgtccccga tgcgcgggcg gtcatcgaag 551 gtcgtctgaa cggcaatatt gccgatgcgcgggcttggtc ggggctgctg 601 gtcggcagta tcgtctgcta cggcatcctg ccgcgcctcttggcttgggt 651 agtgtgtaaa atccttttga aaacaagcga aaacggattg gatttggaaa701 aaacctatta tcaggcggtc atccgccgct ggcagaacaa aatcaccgat 751gcggatacgc gtcgggaaac cgtgtccgcc gtttcgccga aaatcgtctt 801 gaacgatgcgccgaaatggg cgctcatgct ggagaccgag tggcaggacg 851 gccaatggtt cgagggcaggctggcgcagg aatggctgga taagggcgtt 901 gccgccaatc gggaacaggt tgccgcgctggagacagagc tgaagcagaa 951 accggcgcaa ctgcttatcg gcgtacgcgc ccaaactgtgccggaccggg 1001 gcgtgctgcg gcagattgtg cggctttcgg aagcggcgca gggcggcgcg1051 gtggtgcagc ttttggcgga acaggggctt tcagacgacc tttcggaaaa 1101gctggaacat tggcgtaacg cgctgaccga atgcggcgcg gcgtggcttg 1151 agcctgacagggtggcgcag gaaggccgtt tgaaagacca ataaThis corresponds to the amino acid sequence <SEQ ID 988; ORF 253.ng>:

g253.pep 1 MIDRDRMLRD TLERVRAGSF WLWVVVASMM FTAGFSGTYL LMDNQGLNFF 51LVLAGVLGMN TLMLAVWLAT LFLRVKVGRF FSSPATWFRG KGPVNQAVLR 101 LYADQWRQPSVRWKIGATAH SLWLCTLLGM LVSVLLLLLV RQYTFNWEST 151 LLSNAASVRA VEMLAWLPSKLGFPVPDARA VIEGRLNGNI ADARAWSGLL 201 VGSIVCYGIL PRLLAWVVCK ILLKTSENGLDLEKTYYQAV IRRWQNKITD 251 ADTRRETVSA VSPKIVLNDA PKWALMLETE WQDGQWFEGRLAQEWLDKGV 301 AANREQVAAL ETELKQKPAQ LLIGVRAQTV PDRGVLRQIV RLSEAAQGGA351 VVQLLAEQGL SDDLSEKLEH WRNALTECGA AWLEPDRVAQ EGRLKDQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 989>:

m253.seq 1 ATGATTGACA GGAACCGTAT GCTGCGGGAG ACGTTGGAAC GTGTGCGTGC 51GGGGTCGTTC TGGTTGTGGG TGGTGGCGGC GACGTTTGCA TTTTTTACCG 101 GTTTTTCAGTCACTTATCTT CTAATGGACA ATCAGGGTCT GAATTTCTTT 151 TTGGTTTTGG CGGGCGTGTTGGGCATGAAT ACGCTGATGC TGGCAGTATG 201 GTTGGCAATG TTGTTCCTGC GTGTGAAAGTGGGGCGTTTT TTCAGCAGTC 251 CGGCGACGTG GTTTCGGGGC AAAGACCCTG TAAATCAGGCGGTGTTGCGG 301 CTGTATGCGG ACGAGTGGCG GCAACCTTCG GTACGTTGGA AAATAGGCGC351 AACGTCGCAC AGCCTGTGGC TCTGCACGCT GCTCGGAATG CTGGTGTCGG 401TATTGTTGCT GCTTTTGGTG CGGCAATATA CGTTCAACTG GGAAAGCACG 451 CTGTTGAGCAATGCCGCTTC GGTACGCGCG GTGGAAATGT TGGCATGGCT 501 GCCGTCGAAA CTCGGTTTCCCTGTCCCCGA TGCGCGGGCG GTCATCGAAG 551 GCCGTCTGAA CGGCAATATT GCCGATGCGCGGGCTTGGTC GGGGCTGCTG 601 GTCGGCAGTA TCGCCTGCTA CGGCATCCTG CCGCGCCTGCTGGCTTGGGT 651 AGTGTGTAAA ATCCTTTTGA AAACAAGCGA AAACGGATTG GATTTGGAAA701 AGCCCTATTA TCAGGCGGTC ATCCGCCGCT GGCAGAACAA AATCACCGAT 751GCGGATACGC GTCGGGAAAC CGTGTCCGCC GTTTCACCGA AAATCATCTT 801 GAACGATGCGCCGAAATGGG CGGTCATGCT GGAGACCGAG TGGCAGGACG 851 GCGAATGGTT CGAGGGCAGGCTGGCGCAGG AATGGCTGGA TAAGGGCGTT 901 GCCACCAATC GGGAACAGGT TGCCGCGCTGGAGACAGAGC TGAAGCAGAA 951 ACCGGCGCAA CTGCTTATCG GCGTGCGCGC CCAAACTGTGCCGGACCGCG 1001 GCGTGTTGCG GCAGATTGTC CGACTCTCGG AAGCGGCGCA GGGCGGCGCG1051 GTGGTGCAGC TTTTGGCGGA ACAGGGGCTT TCAGACGACC TTTCGGAAAA 1101GCTGGAACAT TGGCGTAACG CGCTGGCCGA ATGCGGCGCG GCGTGGCTTG 1151 AGCCTGACAGGGCGGCGCAG GAAGGGCGTT TGAAAGACCA ATAAThis corresponds to the amino acid sequence <SEQ ID 990; ORF 253>:

m253.pep 1 MIDRNRMLRE TLERVRAGSF WLWVVAATFA FFTGFSVTYL LMDNQGLNFF 51LVLAGVLGMN TLMLAVWLAM LFLRVKVGRF FSSPATWFRG KDPVNQAVLR 101 LYADEWRQPSVRWKIGATSH SLWLCTLLGM LVSVLLLLLV RQYTFNWEST 151 LLSNAASVRA VEMLAWLPSKLGFPVPDARA VIEGRLNGNI ADARAWSGLL 201 VGSIACYGIL PRLLAWVVCK ILLKTSENGLDLEKPYYQAV IRRWQNKITD 251 ADTRRETVSA VSPKIILNDA PKWAVMLETE WQDGEWFEGRLAQEWLDKGV 301 ATNREQVAAL ETELKQKPAQ LLIGVRAQTV PDRGVLRQIV RLSEAAQGGA351 VVQLLAEQGL SDDLSEKLEH WRNALAECGA AWLEPDRAAQ EGRLKDQ*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 253 shows 94.7% identity over a 397 aa overlap with a predicted ORF(ORF 253.ng) from N. gonorrhoeae.

m253/g253         10        20        30        40        50        60m253.pep MIDRNRMLRETLERVRAGSFWLWVVAATFAFFTGFSVTYLLMDNQGLNFFLVLAGVLGMN||||:||||:|||||||||||||||:|:: | :||| ||||||||||||||||||||||| g253MIDRDRMLRDTLERVRAGSFWLWVVVASMMFTAGFSGTYLLMDNQGLNFFLVLAGVLGMN        10        20        30        40        50        60        70        80        90       100       110       120 m253.pepTLMLAVWLAMLFLRVKVGRFFSSPATWFRGKDPVNQAVLRLYADEWRQPSVRWKIGATSH||||||||| ||||||||||||||||||||| ||||||||||||:|||||||||||||:| g253TLMLAVWLATLFLRVKVGRFFSSPATWFRGKGPVNQAVLRLYADQWRQPSVRWKIGATAH        70        80        90       100       110       120       130       140       150       160       170       180 m253.pepSLWLCTLLGMLVSVLLLLLVRQYTFNWESTLLSNAASVRAVEMLAWLPSKLGFPVPDARA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g253SLWLCTLLGMLVSVLLLLLVRQYTFNWESTLLSNAASVRAVEMLAWLPSKLGFPVPDARA       130       140       150       160       170       180       190       200       210       220       230       240 m253.pepVIEGRLNGNIADARAWSGLLVGSIACYGILPRLLAWVVCKILLKTSENGLDLEKPYYQAV||||||||||||||||||||||||:||||||||||||||||||||||||||||| ||||| g253VIEGRLNGNIADARAWSGLLVGSIVCYGILPRLLAWVVCKILLKTSENGLDLEKTYYQAV       190       200       210       220       230       240       250       260       270       280       290       300 m253.pepIRRWQNKITDADTRRETVSAVSPKIILNDAPKWAVMLETEWQDGEWFEGRLAQEWLDKGV|||||||||||||||||||||||||:||||||||:|||||||||:||||||||||||||| g253IRRWQNKITDADTRRETVSAVSPKIVLNDAPKWALMLETEWQDGQWFEGRLAQEWLDKGV       250       260       270       280       290       300       310       320       330       340       350       360 m253.pepATNREQVAALETELKQKPAQLLIGVRAQTVPDRGVLRQIVRLSEAAQGGAVVQLLAEQGL|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g253AANREQVAALETELKQKPAQLLIGVRAQTVPDRGVLRQIVRLSEAAQGGAVVQLLAEQGL       310       320       330       340       350       360       370       380       390 m253.pepSDDLSEKLEHWRNALAECGAAWLEPDRAAQEGRLKDQX|||||||||||||||:|||||||||||:|||||||||| g253SDDLSEKLEHWRNALTECGAAWLEPDRVAQEGRLKDQX        370       380       390The following partial DNA sequence was identified in N. meningitidis<SEQ ID 991>:

a253.seq 1 ATGATCGACA GGAACCGTAT GCTGCGGGAG ACGTTGGAAC GTGTGCGTGC 51GGGGTCGTTC TGGTTGTGGG TGGCGGCGGC GACGTTTGCG TTTTTTACCG 101 GTTTTTCAGTTACTTATCTT CTAATGGACA ATCAGGGTCT GAATTTCTTT 151 TTGGTTTTGG CGGGCGTGTTGGGCATGAAT ACGCTGATGC TGGCAGTATG 201 GTTGGCAATG TTGTTCCTGC GCGTGAAAGTGGGGCGTTTT TTCAGCAGTC 251 CGGCGACGTG GTTTCGGGGC AAAGACCCTG TCAATCAGGCGGTGTTGCGG 301 CTGTATGCGG ACGAGTGGCG GCAACCTTCG GTACGTTGGA AAATAGGCGC351 AACGTCGCAC AGCCTGTGGC TCTGCACGCT GCTCGGAATG CTGGTGTCGG 401TATTGTTGCT GCTTTTGGTG CGGCAATATA CGTTCAACTG GGAAAGCACG 451 CTGTTGGGCGATTCGTCTTC GGTACGGCTG GTGGAAATGT TGGCATGGCT 501 GCCTGCGAAA CTGGGTTTTCCCGTGCCTGA TGCGCGGGCG GTCATCGAAG 551 GTCGTCTGAA CGGCAATATT GCCGATGCGCGGGCTTGGTC GGGGCTGCTG 601 GTCGGCAGTA TCGCCTGCTA CGGCATCCTG CCGCGCCTCTTGGCTTGGGC 651 GGTATGCAAA ATCCTTTTGA AAACAAGCGA AAACGGCTTG GATTTGGAAA701 AGCCCTATTA TCAGGCGGTC ATCCGCCGCT GGCAGAACAA AATCACCGAT 751GCGGATACGC GTCGGGAAAC CGTGTCCGCC GTTTCGCCGA AAATCGTCTT 801 GAACGATGCGCCGAAATGGG CGGTCATGCT GGAGACCGAA TGGCAGGACG 851 GCGAATGGTT CGAGGGCAGGCTGGCGCAGG AATGGCTGGA TAAGGGCGTT 901 GCCGCCAATC GGGAACAGGT TGCCGCGCTGGAGACAGAGC TGAAGCAGAA 951 ACCGGCGCAA CTGCTTATCG GCGTGCGCGC CCAAACTGTGCCCGACCGCG 1001 GCGTGTTGCG GCAGATCGTC CGACTTTCGG AAGCGGCGCA GGGCGGCGCG1051 GTGGTGCAGC TTTTGGCGGA ACAGGGGCTT TCAGACGACC TTTCGGAAAA 1101GCTGGAACAT TGGCGTAACG CGCTGACCGA ATGCGGCGCG GCGTGGCTGG 1151 AACCCGACAGAGCGGCGCAG GAAGGCCGTC TGAAAACCAA CGACCGCACT 1201 TGAThis corresponds to the amino acid sequence <SEQ ID 992; ORF 253.a>:

a253.pep > 1 MIDRNRMLRE TLERVRAGSF WLWVAAATFA FFTGFSVTYL LMDNQGLNFF 51LVLAGVLGMN TLMLAVWLAM LFLRVKVGRF FSSPATWFRG KDPVNQAVLR 101 LYADEWRQPSVRWKIGATSH SLWLCTLLGM LVSVLLLLLV RQYTFNWEST 151 LLGDSSSVRL VEMLAWLPAKLGFPVPDARA VIEGRLNGNI ADARAWSGLL 201 VGSIACYGIL PRLLAWAVCK ILLKTSENGLDLEKPYYQAV IRRWQNKITD 251 ADTRRETVSA VSPKIVLNDA PKWAVMLETE WQDGEWFEGRLAQEWLDKGV 301 AANREQVAAL ETELKQKPAQ LLIGVRAQTV PDRGVLRQIV RLSEAAQGGA351 VVQLLAEQGL SDDLSEKLEH WRNALTECGA AWLEPDRAAQ EGRLKTNDRT 401 *m253/a253 97.2% identity in 395 aa overlap        10        20        30        40        50        60 m253.pepMIDRNRMLRETLERVRAGSFWLWVVAATFAFFTGFSVTYLLMDNQGLNFFLVLAGVLGMN||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||| a253MIDRNRMLRETLERVRAGSFWLWVAAATFAFFTGFSVTYLLMDNQGLNFFLVLAGVLGMN        10        20        30        40        50        60        70        80        90       100       110       120 m253.pepTLMLAVWLAMLFLRVKVGRFFSSPATWFRGKDPVNQAVLRLYADEWRQPSVRWKIGATSH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a253TLMLAVWLAMLFLRVKVGRFFSSPATWFRGKDPVNQAVLRLYADEWRQPSVRWKIGATSH        70        80        90       100       110       120       130       140       150       160       170       180 m253.pepSLWLCTLLGMLVSVLLLLLVRQYTFNWESTLLSNAASVRAVEMLAWLPSKLGFPVPDARA||||||||||||||||||||||||||||||||::::||| ||||||||:||||||||||| a253SLWLCTLLGMLVSVLLLLLVRQYTFNWESTLLGDSSSVRLVEMLAWLPAKLGFPVPDARA       130       140       150       160       170       180       190       200       210       220       230       240 m253.pepVIEGRLNGNIADARAWSGLLVGSIACYGILPRLLAWVVCKILLKTSENGLDLEKPYYQAV||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||| a253VIEGRLNGNIADARAWSGLLVGSIACYGILPRLLAWAVCKILLKTSENGLDLEKPYYQAV       190       200       210       220       230       240       250       260       270       280       290       300 m253.pepIRRWQNKITDADTRRETVSAVSPKIILNDAPKWAVMLETEWQDGEWFEGRLAQEWLDKGV|||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||| a253IRRWQNKITDADTRRETVSAVSPKIVLNDAPKWAVMLETEWQDGEWFEGRLAQEWLDKGV       250       260       270       280       290       300       310       320       330       340       350       360 m253.pepATNREQVAALETELKQKPAQLLIGVRAQTVPDRGVLRQIVRLSEAAQGGAVVQLLAEQGL|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a253AANREQVAALETELKQKPAQLLIGVRAQTVPDRGVLRQIVRLSEAAQGGAVVQLLAEQGL       310       320       330       340       350       360       370       380       390 m253.pepSDDLSEKLEHWRNALAECGAAWLEPDRAAQEGRLKDQX|||||||||||||||:||||||||||||||||||| a253SDDLSEKLEHWRNALTECGAAWLEPDRAAQEGRLKTNDRTX       370       380       390       400The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 993>:

g254.seq 1 atgtatgcag gcgaacgctt caatacttac agccatttga gcggtttgat 51tctggcggcg gcaggtttga tgctgatgct gctgaaaacc ataggacacg 101 gggacggataccgtatcttc agcgtatcgg tttacggcat cagccttctt 151 ctgctctatt tgagttcctcgctgtaccac ggaattgcag ccggaaaact 201 gaaaagcatt ttgaaaaaaa ccgaccactgcatgatttat gtgctgattg 251 ccggaagcta cacaccgttt gcactggttt ctttgagaaacgggccgggc 301 tggacggtat tttcactgtc ctggctgctg gcggctgcag gaatcgcaca351 agaactcacc atcggacgga aaagcgaaaa acgtctgctg tctattgcga 401tttatatcgt aatgggctgg atggtcttgg cggtaatgaa atccctgaca 451 gcctcactcccgccggcagg actggcttgg ctggcggcag gcggtatgct 501 gtacagcgtc ggcatttactggtttgtaaa cgatgaaaaa atccgacacg 551 ggcacggaat ctggcatctg ttcgtattgggcggcagcat aacccaattt 601 gtcagcgtgt acggttatgt aatctgaThis corresponds to the amino acid sequence <SEQ ID 994; ORF 254.ng>:

g254.pep 1 MYAGERFNTY SHLSGLILAA AGLMLMLLKT IGHGDGYRIF SVSVYGISLL 51LLYLSSSLYH GIAAGKLKSI LKKTDHCMIY VLIAGSYTPF ALVSLRNGPG 101WTVFSLSWLL AAAGIAQELT IGRKSEKRLL SIAIYIVMGW MVLAVMKSLT 151 ASLPPAGLAWLAAGGMLYSV GIYWFVNDEK IRHGHGIWHL FVLGGSITQF 201 VSVYGYVI*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 995>:

m254.seq (partial) 1 ..GTATCGGTTT ACGGCATCAG CCTTCTTCTG CTCTATTTGAGTTCCTGGCT 51   GTACCACGGA ATTGCAGCCG GAAAACTGAA AAGCATTTTG AAAAAAACCG101   ACCACTGCAT GATTTATGTG CTGATTGCCG GAAGCTACAC ACCGTTTGCA 151  CTGGTTTCTT TGAGAAACGG GCCGGGCTGG ACGGTATTTT CACTGTCCTG 201  GCTGCTGGCG GCTGCAGGAA TCGCACAAGA ACTCACCATC GGACGGAAAA 251  GCGAAAAACG TCTGCTGTCT ATTGTGATTT ATGTCGTCAT GGGTTGGATG 301  GTCTTGGCGG TAATGAAATC CCTGACAGCC TCACTCCCGT CGGCAGGACT 351  GGCTTGGCTG GCGGCAGGCG GTATGCTGTA CAGTGTCGGC ATTTACTGGT 401  TTGTAAACGA TGAAAAAATC CGACACGGGC ACGGAATCTG GCATCTGTTC 451  GTATTGGGCG GCAGCATCAC CCAATTTGTC AGCGTGTACG GTTACGTAAT 501   CTGAThis corresponds to the amino acid sequence <SEQ ID 996; ORF 254>:

m254.pep (partial) 1 ..VSVYGISLLL LYLSSWLYHG IAAGKLKSIL KKTDHCMIYVLIAGSYTPFA 51   LVSLRNGPGW TVFSLSWLLA AAGIAQELTI GRKSEKRLLS IVIYVVMGWM101   VLAVMKSLTA SLPSAGLAWL AAGGMLYSVG IYWFVNDEKI RHGHGIWHLF 151  VLGGSITQFV SVYGYVI*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 254 shows 97.6% identity over a 167 aa overlap with a predicted ORF(ORF 254.ng) from N. gonorrhoeae:

m254/g254                                       10        20        30m254.pep                               VSVYGISLLLLYLSSWLYHGIAAGKLKSIL                              ||||||||||||||| |||||||||||||| g254HLSGLILAAAGLMLMLLKTIGHGDGYRIFSVSVYGISLLLLYLSSSLYHGIAAGKLKSIL       20        30        40        50        60        70        40        50        60        70        80        90 m254.pepKKTDHCMIYVLIAGSYTPFALVSLRNGPGWTVFSLSWLLAAAGIAQELTIGRKSEKRLLS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g254KKTDHCMIYVLIAGSYTPFALVSLRNGPGWTVFSLSWLLAAAGIAQELTIGRKSEKRLLS       80        90       100       110       120       130       100       110       120       130       140       150 m254.pepIVIYVVMGWMVLAVMKSLTASLPSAGLAWLAAGGMLYSVGIYWFVNDEKIRHGHGIWHLF|:||:|||||||||||||||||| |||||||||||||||||||||||||||||||||||| g254IAIYIVMGWMVLAVMKSLTASLPPAGLAWLAAGGMLYSVGIYWFVNDEKIRHGHGIWHLF      140       150       160       170       180       190        160m254.pep VLGGSITQFVSVYGYVIX |||||||||||||||||| g254 VLGGSITQFVSVYGYVIX      200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 997>:

a254.seq 1 ATGTATACAG GCGAACGCTT CAATACTTAC AGCCATTTGA GCGGTTTGAT 51TCTGGCGGCG GCAGGTTTGG CGCTGATGCT GCTGAAAACC ATAGGACACG 101 GGGACGGCTACCGTATCTTC AGCGTATCGG TTTACGGCAT CAGCCTTCTT 151 CTGCTCTATT TGAGTTCCTCGCTGTACCAC GGAATTGCAG CCGGAAAACT 201 GAAAAGCATT TTGAAAAAAA CCGACCACTGCATGATTTAT GTGCTGATTG 251 CCGGAAGCTA CACACCGTTT GCACTGGTTT CTTTGAGAAACGGGCCGGGC 301 TGGACGGTAT TTTCACTGTC CTGGCTGCTG GCGGCTGCAG GAATCGCACA351 AGAACTCACC ATTGGACGGA AAAGCGAAAA ACGACTGCTG TCTATTGCGA 401TTTATATCGT AATGGGCTGG ATGGTCTTGG CGGTAATGAA ATCCCTGACA 451 GCCTCACTCCCGCCGGCAGG ACTGGCTTGG CTGGCGGCAG GCGGTATGCT 501 GTACAGCGTC GGCATTTACTGGTTTGTAAA CGATGAAAAA ATCCGACACG 551 GGCACGGAAT CTGGCATCTG TTCGTATTGGGCGGCAGCAT CACCCAATTT 601 GTCAGCGTGT ACGGTTACGT AATCTGAThis corresponds to the amino acid sequence <SEQ ID 998; ORF 254.a>:

a254.pep 1 MYTGERFNTY SHLSGLILAA AGLALMLLKT IGHGDGYRIF SVSVYGISLL 51LLYLSSSLYH GIAAGKLKSI LKKTDHCMIY VLIAGSYTPF ALVSLRNGPG 101 WTVFSLSWLLAAAGIAQELT IGRKSEKRLL SIAIYIVMGW MVLAVMKSLT 151 ASLPPAGLAW LAAGGMLYSVGIYWFVNDEK IRHGHGIWHL FVLGGSITQF 201 VSVYGYVI* m254/a254 97.6% identityin 167 aa overlap                                      10        20        30 m254.pep                              VSVYGISLLLLYLSSWLYHGIAAGKLKSIL                              ||||||||||||||| |||||||||||||| a254HLSGLILAAAGLALMLLKTIGHGDGYRIFSVSVYGISLLLLYLSSSLYHGIAAGKLKSIL       20        30        40        50        60        70        40        50        60        70        80        90 m254.pepKKTDHCMIYVLIAGSYTPFALVSLRNGPGWTVFSLSWLLAAAGIAQELTIGRKSEKRLLS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a254KKTDHCMIYVLIAGSYTPFALVSLRNGPGWTVFSLSWLLAAAGIAQELTIGRKSEKRLLS       80        90       100       110       120       130       100       110       120       130       140       150 m254.pepIVIYVVMGWMVLAVMKSLTASLPSAGLAWLAAGGMLYSVGIYWFVNDEKIRHGHGIWHLF|:||:|||||||||||||||||| |||||||||||||||||||||||||||||||||||| a254IAIYIVMGWMVLAVMKSLTASLPPAGLAWLAAGGMLYSVGIYWFVNDEKIRHGHGIWHLF      140       150       160       170       180       190        160m254.pep VLGGSITQFVSVYGYVIX |||||||||||||||||| a254 VLGGSITQFVSVYGYVIX      200The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 999>:

g255.seq 1 atggttggac aggaagcctt gcggggtcag ttcgtcgccg tgttcgctgc 51cgcgttgcgt tacgctgtca aaacctgcgc cgatttccac gcctttgacg 101 gcgttgatgcccatcatcgc gtaggcgatt tcggcatcga ggcggtcgaa 151 aacgggttcg cccaaaccgacggggacgtt ggcggcttcg atatgcagtt 201 tcgcgccgac ggaatccaag gatttgcgcacaccgtccat atagtgttcc 251 agttcggcga tttggctttg gttggcggca aaaaaaggattttgggaaat 301 gtgttcgctg ccttcaaacc ggattttttt ttcgccgact tgggtaacgt351 aggcggtgat ttccgtgccg aatttttctt tcagccattt tttggcaacg 401gctccggcgg caacgcgggc tgcggtttcg cgggcggaac tcctgccgcc 451 gccccggtagtcgcgcgtac cgtatttgtg ccaataggta tagtcggcgt 501 gtccggggcg gaaggcggtggcgatgtcgc cgtagtcttc gctgcgctgg 551 tcggtgttgc ggattagThis corresponds to the amino acid sequence <SEQ ID 1000; ORF 255.ng>:

g255.pep 1 MVGQEALRGQ FVAVFAAALR YAVKTCADFH AFDGVDAHHR VGDFGIEAVE 51NGFAQTDGDV GGFDMQFRAD GIQGFAHTVH IVFQFGDLAL VGGKKRILGN 101 VFAAFKPDFFFADLGNVGGD FRAEFFFQPF FGNGSGGNAG CGFAGGTPAA 151 APVVARTVFV PIGIVGVSGAEGGGDVAVVF AALVGVAD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1001>:

m255.seq 1 GTGGTTGGAC AGGAAGCCTT GCGGGGTCAG TTCGTCGCCG TGTTCGCTGC 51CGCGTTGCGT TACGCTGTCA AAACCTGCGC CGATTTCCAC GCCTTTGACG 101 GCGTTGATGCCCATCATCGC GTAGGCGATT TCGGCATCGA GGCGGTCAAA 151 AACAGGTTCG CCCAAGCCGACAGGGACATT GGCTGCTTCG ATATGCAGCT 201 TCGCGCCGAC GGAATCCAAG GATTTGCGCACGCTGTCCAT ATAGTTTTCC 251 AGCTCGGCAA TTTGGCTATG GTTGGCGGCA AAAAAAGGATTTTGGGAAAT 301 GTGTTCGCAG CCTTCAAACC GGATTTCTTT TTCGCCGACT TGGGTAACGT351 AGGCGGTGAT TTCCGTGCCG AATTTTTCTT TCAACCATTT TTTGGCAACG 401GCTCCGGCAG CAACGCGGGC GGCGGTTTCA CGGGCGGAGC TCCTGCCGCC 451 GCCGCGGTAGTCGCGCGTGC CGTATTTGTG CCAATAGGTA TAGTCGGCGT 501 GGCCGGGGCG GAAGCTGGTGGCGATGTTGC CGTAGTCTTT GCTGCGCTGG 551 TCGGTATTGC GGATTAAThis corresponds to the amino acid sequence <SEQ ID 1002; ORF 255>:

m255.pep 1 VVGQEALRGQ FVAVFAAALR YAVKTCADFH AFDGVDAHHR VGDFGIEAVK 51NRFAQADRDI GCFDMQLRAD GIQGFAHAVH IVFQLGNLAM VGGKKRILGN 101 VFAAFKPDFFFADLGNVGGD FRAEFFFQPF FGNGSGSNAG GGFTGGAPAA 151 AAVVARAVFV PIGIVGVAGAEAGGDVAVVF AALVGIAD*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 255 shows 88.8% identity over a 188 aa overlap with a predicted ORF(ORF 255.ng) from N. gonorrhoeae:

m255/g255         10        20        30        40        50        60m255.pep VVGQEALRGQFVAVFAAALRYAVKTCADFHAFDGVDAHHRVGDFGIEAVKNRFAQADRDI:||||||||||||||||||||||||||||||||||||||||||||||||:| |||:| |: g255MVGQEALRGQFVAVFAAALRYAVKTCADFHAFDGVDAHHRVGDFGIEAVENGFAQTDGDV        10        20        30        40        50        60        70        80        90       100       110       120 m255.pepGCFDMQLRADGIQGFAHAVHIVFQLGNLAMVGGKKRILGNVFAAFKPDFFFADLGNVGGD| ||||:||||||||||:||||||:|:||:|||||||||||||||||||||||||||||| g255GGFDMQFRADGIQGFAHTVHIVFQFGDLALVGGKKRILGNVFAAFKPDFFFADLGNVGGD        70        80        90       100       110       120       130       140       150       160       170       180 m255.pepFRAEFFFQPFFGNGSGSNAGGGFTGGAPAAAAVVARAVFVPIGIVGVAGAEAGGDVAVVF||||||||||||||||:||| ||:||:|||| ||||:||||||||||:|||:|||||||| g255FRAEFFFQPFFGNGSGGNAGCGFAGGTPAAAPVVARTVFVPIGIVGVSGAEGGGDVAVVF       130       140       150       160       170       180       189m255.pep AALVGIADX |||||:||| g255 AALVGVADXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1003>:

a255.seq 1 GTGGTTGGAC AGGAAGCCTT GCGGGGTGAG TTCGTCGCCG TGTTCGCTGC 51CGCGTTGCGT TACGCTGTCA AAACCTGCGC CGATTTCCAC GCCTTTGACG 101 GCGTTGATGCCCATCATGGC GTAGGCGATT TCGGCATCGA GGCGGTCGAA 151 TACGGGTTCG CCCAAGCCGACGGGGACGTT GGCGGCTTCA ATATGCAGCT 201 TCGCGCCGAC GGAATCCAAG GATTTGCGCACGCTGTCCAT ATAGTTTTCC 251 AGCTCGGCAA TTTGGCTATG GTTGGCGGCA AAAAAAGGATTTTGGGAAAT 301 GTGTTCGCAG CCTTCAAACC GGATTTCTTT TTCGCCGACT TGGGTAACGT351 AGGCGGTGAT TTCCGTGCCG AATTTTTCTT TCAACCATTT TTTGGCAACG 401GCTCCGGCGG CAACGCGGGC GGCGGTTTCG CGGGCGGAAC TCCTGCCGCC 451 GCCCCGGTAGTCGCGCGTGC CGTATTTGTG CCAATAGGTA TAGTCGGCGT 501 GGCCGGGGCG GAAGCTGGTGGCGATGTTGC CGTAGTCTTT GCTGCGCTGG 551 TCGGTATTGC GGATTAAThis corresponds to the amino acid sequence <SEQ ID 1004; ORF 255.a>:

a255.pep 1 VVGQEALRGE FVAVFAAALR YAVKTCADFH AFDGVDAHHG VGDFGIEAVE 51YGFAQADGDV GGFNMQLRAD GIQGFAHAVH IVFQLGNLAM VGGKKRILGN 101 VFAAFKPDFFFADLGNVGGD FRAEFFFQPF FGNGSGGNAG GGFAGGTPAA 151 APVVARAVFV PIGIVGVAGAEAGGDVAVVF AALVGIAD* m255/a255 93.1% identity in 188 aa overlap        10        20        30        40        50        60 m255.pepVVGQEALRGQFVAVFAAALRYAVKTCADFHAFDGVDAHHRVGDFGIEAVKNRFAQADRDI|||||||||:||||||||||||||||||||||||||||| |||||||||:  ||||| |: a255VVGQEALRGEFVAVFAAALRYAVKTCADFHAFDGVDAHHGVGDFGIEAVEYGFAQADGDV        10        20        30        40        50        60        70        80        90       100       110       120 m255.pepGCFDMQLRADGIQGFAHAVHIVFQLGNLAMVGGKKRILGNVFAAFKPDFFFADLGNVGGD| |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||| a255GGFNMQLRADGIQGFAHAVHIVFQLGNLAMVGGKKRILGNVFAAFKPDFFFADLGNVGGD        70        80        90       100       110       120       130       140       150       160       170       180 m255.pepFRAEFFFQPFFGNGSGSNAGGGFTGGAPAAAAVVARAVFVPIGIVGVAGAEAGGDVAVVF||||||||||||||||:||||||:||:|||| |||||||||||||||||||||||||||| a255FRAEFFFQPFFGNGSGGNAGGGFAGGTPAAAPVVARAVFVPIGIVGVAGAEAGGDVAVVF       130       140       150       160       170       180       189m255.pep AALVGIADX ||||||||| a255 AALVGIADXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1005>:

g256.seq 1 atgctcgcgg tacgcaatcg gggttggcac ggcgcagtcg tccatttccg 51cagctgcggc ggcgtagcga acaccgcccc ggtgttctac cacttgggtg 101 ataccgccgaaatcgccttt gctttggaca cgctcaccgc gcgttaccgt 151 gaaatatacg ccgtcggcgtatcgctgggc ggcaacgcgc cggcaaaata 201 tttgggcgaa cagggcaaaa aggcattgccgcacgcctcg gccgccgtat 251 ccgcccccgt tgatgcagag gcggcaggca gccgcttcgacagcggcatc 301 acgcggctgc tctacacgcg ctacttcctc cgcacactga tacccaaagc351 acgttcgctc caaggttttc agacggcatt tgccgcaggg tgcaaaacac 401tgggcgagtt tgacgaccgt ttcaccgcac cgctgcacgg ctttgccgac 451 cggcacgactactaccgcca aacttcctgc aaaccgctgc tcaaacacgt 501 tgccaaaccg ctgctcctgctcaatgccgc caacgacccc ttcctgccgc 551 ccgaagccct gccccgtgca gacgaagcgtccgaagccgt taccctgttc 601 caacctgcac acggcgggca cgccggcttt gtcagcagcaccggcggcag 651 gctgcacctg caatggctgc cgcagaccgt cctgtcctat tttgacagct701 tccgcacaaa caggcgttaaThis corresponds to the amino acid sequence <SEQ ID 1006; ORF 256.ng>:

g256.pep 1 MLAVRNRGWH GAVVHFRSCG GVANTAPVFY HLGDTAEIAF ALDTLTARYR 51EIYAVGVSLG GNAPAKYLGE QGKKALPHAS AAVSAPVDAE AAGSRFDSGI 101 TRLLYTRYFLRTLIPKARSL QGFQTAFAAG CKTLGEFDDR FTAPLHGFAD 151 RHDYYRQTSC KPLLKHVAKPLLLLNAANDP FLPPEALPRA DEASEAVTLF 201 QPAHGGHAGF VSSTGGRLHL QWLPQTVLSYFDSFRTNRR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1007>:

m256.seq 1 ATGCTTGCGG TACGCGATCG GGGTTGGCAC GGCGTAGTCG TCCATTTCCG 51CAGCTGCGGC GGCATTGCCA ACACCGCTCC GGTGTTCTAC CA.CTtGGCG 101 ATACCGCCGAAATCGCCTTT ACTTTGGACA CGTTCGCCGC GCGTTACCGT 151 GAAAtATACG CCGTCGGCGTATCGCTGGGC GGCAACGCGC TGGCAAAATA 201 TTTGGGCGAA CAGGGCAAAA AGGCATTGCCGCAAGCCGCT GCCGTCATCT 251 CCGCCCCCGT CGATGCAGAG GCGGCAGGCA GACGCTTCGACAGCGGCATC 301 ACGCGGCTGC TCTACACGCG CTACTTCCTC CGCACCCTGA TACCCAAAGC351 AAAATCGCTC CAAGGTTTTC AGACGGCATT TGCCGCAGGG TGCAAAACAC 401TGGGCGAGTT TGACGACCGC TTCACCGCAC CGCTGCACGG CTTTGCCGAC 451 CGGCACGACTACTACCGCCA AACTTCCTGC AAACCGCTGC TCAAACACGT 501 TGCCAAACCG CTGCTCCTGCTCAATGCCGT CAACGACCCC TTCCTGCCGC 551 CCGAAGCCGT GCCCCGCGCA GACGAAGTATCCGAAGCCGT TACCCTGTTC 601 CAGCCGGCAT ATGGTGGTCA TGTCGGCTTT GTCAGCAGCACCGGCGGCAG 651 GCTGCACCTG CAATGGCTGC CGCAGACCGT CCTGTCCTAT TTCGACAGCT701 TCCGCACAAA CAGGCGTTAAThis corresponds to the amino acid sequence <SEQ ID 1008; ORF 256>:

m256.pep 1 MLAVRDRGWH GVVVHFRSCG GIANTAPVFY XLGDTAEIAF TLDTFAARYR 51EIYAVGVSLG GNALAKYLGE QGKKALPQAA AVISAPVDAE AAGRRFDSGI 101 TRLLYTRYFLRTLIPKAKSL QGFQTAFAAG CKTLGEFDDR FTAPLHGFAD 151 RHDYYRQTSC KPLLKHVAKPLLLLNAVNDP FLPPEALPRA DEVSEAVTLF 201 QPAYGGHVGF VSSTGGRLHL QWLPQTVLSYFDSFRTNRR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 256 shows 92.9% identity over a 239 aa overlap with a predicted ORF(ORF 256.ng) from N. gonorrhoeae:

m256/g256         10        20        30        40        50        60m256.pep MLAVRDRGWHGVVVHFRSCGGIANTAPVFYHLGDTAEIAFTLDTFAARYREIYAVGVSLG|||||:|||||:|||||||||:||||||||||||||||||:|||::|||||||||||||| g256MLAVRNRGWHGAVVHFRSCGGVANTAPVFYHLGDTAEIAFALDTLTARYREIYAVGVSLG        10        20        30        40        50        60        70        80        90       100       110       120 m256.pepGNALAKYLGEQGKKALPQAAAVISAPVDAEAAGRRFDSGITRLLYTRYFLRTLIPKAKSL||| |||||||||||||:|:|::|||||||||| |||||||||||||||||||||||:|| g256GNAPAKYLGEQGKKALPHASAAVSAPVDAEAAGSRFDSGITRLLYTRYFLRTLIPKARSL        70        80        90       100       110       120       130       140       150       160       170       180 m256.pepQGFQTAFAAGCKTLGEFDDRFTAPLHGFADRHDYYRQTSCKPLLKHVAKPLLLLNAVNDP||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||| g256QGFQTAFAAGCKTLGEFDDRFTAPLHGFADRHDYYRQTSCKPLLKHVAKPLLLLNAANDP       130       140       150       160       170       180       190       200       210       220       230       240 m256.pepFLPPEALPRADEVSEAVTLFQPAYGGHVGFVSSTGGRLHLQWLPQTVLSYFDSFRTNRRX||||||||||||:||||||||||:|||:|||||||||||||||||||||||||||||||| g256FLPPEALPRADEASEAVTLFQPAHGGHAGFVSSTGGRLHLQWLPQTVLSYFDSFRTNRRX       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1009>:

a256.seq 1 ATGCTCGCGG TACGCGATCG GGGTTGGAAC GGCGTAGTCG TCCATTTCCG 51CAGCTGCGGC GGCGTAGCGA ACACCGCCCC GGTGTTCTAC CACTTGGGCG 101 ATACCGCCGAAATTGCCTTT ACTTTGGACA CGCTCGCCGC GCGTTACCGT 151 GAAATATACG CCGTCGGCGTATCGCTGGGC GGCAACGCGC TGGCAAAATA 201 TTTGGGCGAA CAGGGCGAAA ACGCGCTGCCGCAAGCCGCC GCCGTCATCT 251 CCGAAGCCGT CGATGCAGAG GCGGCAGGCA ACCGCTTCGACAGCGGCATC 301 ACACGGCTGC TCTACACGCG CTACTTCCTC CGCACACTGA TACCCAAAGC351 ACGGTCGCTC CAAGGTTTTC AGACGGCATT TGCCGCAGGG TGCAAAACAC 401TGGGCGAGTT TGACGACCGT TTCACCGCAC CGCTGCACGG CTTTGCCGAT 451 CGGCACGACTACTACCGCCA AACTTCCTGC AAACCGCTGC TCAAACACGT 501 TGCCAAACCG CTGCTCCTGCTCAATGCCGT CAACGACCCC TTCCTGCCGC 551 CCGAAGCGCT GCCCCGCGCA GACGAAGTGTCCGAAGCCGT TACCCTGTTC 601 CAGCCGACAC ACGGTGGTCA TGTCGGCTTT GTCGGCAGCACCGGCGGCAG 651 GCTGCACCTG CAATGGTTGC CGCAGACCGT CCTGTCCTAT TTCGACAGCT701 TCCGCACAAA CAGGCGTTAAThis corresponds to the amino acid sequence <SEQ ID 1010; ORF 256.a>:

a256.pep 1 MLAVRDRGWN GVVVHFRSCG GVANTAPVFY HLGDTAEIAF TLDTLAARYR 51EIYAVGVSLG GNALAKYLGE QGENALPQAA AVISAPVDAE AAGNRFDSGI 101 TRLLYTRYFLRTLIPKARSL QGFQTAFAAG CKTLGEFDDR FTAPLHGFAD 151 RHDYYRQTSC KPLLKHVAKPLLLLNAVNDP FLPPEALPRA DEVSEAVTLF 201 QPTHGGHVGF VGSTGGRLHL QWLPQTVLSYFDSFRTNRR* m256/a256 95.4% identity in 239 aa overlap        10        20        30        40        50        60 m256.pepMLAVRDRGWHGVVVHFRSCGGIANTAPVFYXLGDTAEIAFTLDTFAARYREIYAVGVSLG|||||||||:|||||||||||:|||||||| |||||||||||||:||||||||||||||| a256MLAVRDRGWNGVVVHFRSCGGVANTAPVFYHLGDTAEIAFTLDTLAARYREIYAVGVSLG        10        20        30        40        50        60        70        80        90       100       110       120 m256.pepGNALAKYLGEQGKKALPQAAAVISAPVDAEAAGRRFDSGITRLLYTRYFLRTLIPKAKSL||||||||||||::||||||||||||||||||| |||||||||||||||||||||||:|| a256GNALAKYLGEQGENALPQAAAVISAPVDAEAAGNRFDSGITRLLYTRYFLRTLIPKARSL        70        80        90       100       110       120       130       140       150       160       170       180 m256.pepQGFQTAFAAGCKTLGEFDDRFTAPLHGFADRHDYYRQTSCKPLLKHVAKPLLLLNAVNDP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a256QGFQTAFAAGCKTLGEFDDRFTAPLHGFADRHDYYRQTSCKPLLKHVAKPLLLLNAVNDP       130       140       150       160       170       180       190       200       210       220       230       240 m256.pepFLPPEALPRADEVSEAVTLFQPAYGGHVGFVSSTGGRLHLQWLPQTVLSYFDSFRTNRRX||||||||||||||||||||||::|||||||:|||||||||||||||||||||||||||| a256FLPPEALPRADEVSEAVTLFQPTHGGHVGFVGSTGGRLHLQWLPQTVLSYFDSFRTNRRX       190       200       210       220       230       240The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1011>:

g256-1.seq 1 ATGATTTTGA CACCGCCGGA CACGCCCTTT TTCCTCCGCA ACGGCAATGC 51CGACACGATT GCCGCCAAAT TCCTGCAACA CCCCGCACCC GCATACCGCC 101 GCGAGATGCTTCCCGACAGC ACGGGTAAAA CCAAAACCGC CTACGACTTT 151 TCAGCAGGCG GCATTTCGCCCGATGCGCCG CTGGTCGTGC TGTTTCACGG 201 TTTGGAAGGA AGCAGCCGCA GCCATTACGCGGTCGAACTG ATGCTCGCGG 251 TACGCAATCG GGGTTGGCAC GGCGCAGTCG TCCATTTCCGCAGCTGCGGC 301 GGCGTAGCGA ACACCGCCCC GGTGTTCTAC CACTTGGGTG ATACCGCCGA351 AATCGCCTTT GCTTTGGACA CGCTCACCGC GCGTTACCGT GAAATATACG 401CCGTCGGCGT ATCGCTGGGC GGCAACGCGC CGGCAAAATA TTTGGGCGAA 451 CAGGGCAAAAAGGCATTGCC GCACGCCTCG GCCGCCGTAT CCGCCCCCGT 501 TGATGCAGAG GCGGCAGGCAGCCGCTTCGA CAGCGGCATC ACGCGGCTGC 551 TCTACACGCG CTACTTCCTC CGCACACTGATACCCAAAGC ACGTTCGCTC 601 CAAGGTTTTC AGACGGCATT TGCCGCAGGG TGCAAAACACTGGGCGAGTT 651 TGACGACCGT TTCACCGCAC CGCTGCACGG CTTTGCCGAC CGGCACGACT701 ACTACCGCCA AACTTCCTGC AAACCGCTGC TCAAACACGT TGCCAAACCG 751CTGCTCCTGC TCAATGCCGC CAACGACCCC TTCCTGCCGC CCGAAGCCCT 801 GCCCCGTGCAGACGAAGCGT CCGAAGCCGT TACCCTGTTC CAACCTGCAC 851 ACGGCGGGCA CGCCGGCTTTGTCAGCAGCA CCGGCGGCAG GCTGCACCTG 901 CAATGGCTGC CGCAGACCGT CCTGTCCTATTTTGACAGCT TCCGCACAAA 951 CAGGCGTTAAThis corresponds to the amino acid sequence <SEQ ID 1012; ORF 256-1.ng>:

g256-1.pep 1 MILTPPDTPF FLRNGNADTI AAKFLQHPAP AYRREMLPDS TGKTKTAYDF 51SAGGISPDAP LVVLFHGLEG SSRSHYAVEL MLAVRNRGWH GAVVHFRSCG 101 GVANTAPVFYHLGDTAEIAF ALDTLTARYR EIYAVGVSLG GNAPAKYLGE 151 QGKKALPHAS AAVSAPVDAEAAGSRFDSGI TRLLYTRYFL RTLIPKARSL 201 QGFQTAFAAG CKTLGEFDDR FTAPLHGFADRHDYYRQTSC KPLLKHVAKP 251 LLLLNAANDP FLPPEALPRA DEASEAVTLF QPAHGGHAGFVSSTGGRLHL 301 QWLPQTVLSY FDSFRTNRR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1013>:

m256-1.seq 1 ATGATTTTAA CACCGCCGGA CACGCCCTTT TTCCTCCGCA ACGGCAATGC 51CGACACGATT GCCGCCAAAT TCCTGCAACG CCCCGCGCCC GCATACCGCC 101 GAGAGCTGCTTCCCGACAGC ACGGGTAAAA CCAAAGTCGC CTACGACTTT 151 TCAGACGGCA TTTCGCCCGATGCGCCGCTG GTCGTGCTGT TTCACGGTTT 201 GGAAGGAAGC AGCCGCAGCC ATTACGCGGTCGAACTGATG CTTGCGGTAC 251 GCGATCGGGG TTGGCACGGC GTAGTCGTCC ATTTCCGCAGCTGCGGCGGC 301 ATTGCCAACA CCGCTCCGGT GTTCTACCAC TTGGGCGATA CCGCCGAAAT351 CGCCTTTACT TTGGACACGT TCGCCGCGCG TTACCGTGAA ATATACGCCG 401TCGGCGTATC GCTGGGCGGC AACGCGCTGG CAAAATATTT GGGCGAACAG 451 GGCAAAAAGGCATTGCCGCA AGCCGCTGCC GTCATCTCCG CCCCCGTCGA 501 TGCAGAGGCG GCAGGCAGACGCTTCGACAG CGGCATCACG CGGCTGCTCT 551 ACACGCGCTA CTTCCTCCGC ACCCTGATACCCAAAGCAAA ATCGCTCCAA 601 GGTTTTCAGA CGGCATTTGC CGCAGGGTGC AAAACACTGGGCGAGTTTGA 651 CGACCGCTTC ACCGCACCGC TGCACGGCTT TGCCGACCGG CACGACTACT701 ACCGCCAAAC TTCCTGCAAA CCGCTGCTCA AACACGTTGC CAAACCGCTG 751CTCCTGCTCA ATGCCGTCAA CGACCCCTTC CTGCCGCCCG AAGCCCTGCC 801 CCGCGCAGACGAAGTATCCG AAGCCGTTAC CCTGTTCCAG CCGGCATATG 851 GTGGTCATGT CGGCTTTGTCAGCAGCACCG GCGGCAGGCT GCACCTGCAA 901 TGGCTGCCGC AGACCGTCCT GTCCTATTTCGACAGCTTCC GCACAAACAG 951 GCGTTAAThis corresponds to the amino acid sequence <SEQ ID 1014; ORF 256-1>:

m256-1.pep 1 MILTPPDTPF FLRNGNADTI AAKFLQRPAP AYRRELLPDS TGKTKVAYDF 51SDGISPDAPL VVLFHGLEGS SRSHYAVELM LAVRDRGWHG VVVHFRSCGG 101 IANTAPVFYHLGDTAEIAFT LDTFAARYRE IYAVGVSLGG NALAKYLGEQ 151 GKKALPQAAA VISAPVDAEAAGRRFDSGIT RLLYTRYFLR TLIPKAKSLQ 201 GFQTAFAAGC KTLGEFDDRF TAPLHGFADRHDYYRQTSCK PLLKHVAKPL 251 LLLNAVNDPF LPPEALPRAD EVSEAVTLFQ PAYGGHVGFVSSTGGRLHLQ 301 WLPQTVLSYF DSFRTNRR* m256-1/g256-1 93.1% identity in 319aa overlap          10        20        30        40        50        59m256-1.pep  MILTPPDTPFFLRNGNADTIAAKFLQRPAPAYRRELLPDSTGKTKVAYDFS-DGISPDAP  ||||||||||||||||||||||||||:||||||||:|||||||||:|||||  ||||||| g256-1  MILTPPDTPFFLRNGNADTIAAKFLQHPAPAYRREMLPDSTGKTKLAYDFSAGGISPDAP          10        20        30        40        50        60 60        70        80        90       100       110      119m256-1.pep  LVVLFHGLEGSSRSHYAVELMLAVRDRGWHGVVVHFRSCGGIANTAPVFYHLGDTAEIAF  |||||||||||||||||||||||||:|||||:|||||||||:|||||||||||||||||| g256-1  LVVLFHGLEGSSRSHYAVELMLAVRNRGWHGAVVHFRSCGGVANTAPVFYHLGDTAEIAF          70        80        90       100       110       120120       130       140       150       160       170      179m256-1.pep  TLDTFAARYREIYAVGVSLGGNALAKYLGEQGKKALPQAAAVISAPVDAEAAGRRFDSGI  :|||::||||||||||||||||| |||||||||||||:|:|::|||||||||| |||||| g256-1  ALDTLTARYREIYAVGVSLGGNAPAKYLGEQGKKALPHASAAVSAPVDAEAAGSRFDSGI         130       140       150       160       170       180180       190       200       210       220       230      239m256-1.pep  TRLLYTRYFLRTLIPKAKSLQGFQTAFAAGCKTLGEFDDRFTAPLHGFADRHDYYRQTSC  |||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||| g256-1  TRLLYTRYFLRTLIPKARSLQGFQTAFAAGCKTLGEFDDRFTAPLHGFADRHDYYRQTSC         190       200       210       220       230       240240       250       260       270       280       290      299m256-1.pep  KPLLKHVAKPLLLLNAVNDPFLPPEALPRADEVSEAVTLFQPAYGGHVGFVSSTGGRLHL  ||||||||||||||||:|||||||||||||||:||||||||||:|||:|||||||||||| g256-1  KPLLKHVAKPLLLLNAANDPFLPPEALPRADEASEAVTLFQPAHGGHAGFVSSTGGRLHL         250       260       270       280       290       300300       310      319 m256-1.pep   QWLPQTVLSYFDSFRTNRRX  |||||||||||||||||||| g256-1   QWLPQTVLSYFDSFRTNRRX         310       320The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1015>:

a256-1.seq 1 ATGATTTTGA CACCGCCGGA CACACCCTTT TTCCTCCGCA ACGGCAATGC 51CGACACGATT GCCGCCAAAT TCCTGCAACG CTCCGCACCT GCATACCGCC 101 GCGAGCTGCTTCCCGACAGC ACGGGTAAAA CCAAAACCGC CTACGACTTT 151 TCAGACGGCA TTTCGCCCGATGCGCCGCTG GTCGTGCTGT TTCACGGTTT 201 GGAGGGCGGC AGTGGCAGCC ATTACGCGGTCGAACTGATG CTCGCGGTAC 251 GCGATCGGGG TTGGAACGGC GTAGTCGTCC ATTTCCGCAGCTGCGGCGGC 301 GTAGCGAACA CCGCCCCGGT GTTCTACCAC TTGGGCGATA CCGCCGAAAT351 TGCCTTTACT TTGGACACGC TCGCCGCGCG TTACCGTGAA ATATACGCCG 401TCGGCGTATC GCTGGGCGGC AACGCGCTGG CAAAATATTT GGGCGAACAG 451 GGCGAAAACGCGCTGCCGCA AGCCGCCGCC GTCATCTCCG CACCCGTCGA 501 TGCAGAGGCG GCAGGCAACCGCTTCGACAG CGGCATCACA CGGCTGCTCT 551 ACACGCGCTA CTTCCTCCGC ACACTGATACCCAAAGCACG GTCGCTCCAA 601 GGTTTTCAGA CGGCATTTGC CGCAGGGTGC AAAACACTGGGCGAGTTTGA 651 CGACCGTTTC ACCGCACCGC TGCACGGCTT TGCCGATCGG CACGACTACT701 ACCGCCAAAC TTCCTGCAAA CCGCTGCTCA AACACGTTGC CAAACCGCTG 751CTCCTGCTCA ATGCCGTCAA CGACCCCTTC CTGCCGCCCG AAGCGCTGCC 801 CCGCGCAGACGAAGTGTCCG AAGCCGTTAC CCTGTTCCAG CCGACACACG 851 GTGGTCATGT CGGCTTTGTCGGCAGCACCG GCGGCAGGCT GCACCTGCAA 901 TGGTTGCCGC AGACCGTCCT GTCCTATTTCGACAGCTTCC GCACAAACAG 951 GCGTTAAThis corresponds to the amino acid sequence <SEQ ID 1016; ORF 256-1.a>:

a256-1.pep 1 MILTPPDTPF FLRNGNADTI AAKFLQRSAP AYRRELLPDS TGKTKTAYDF 51SDGISPDAPL VVLFHGLEGG SGSHYAVELM LAVRDRGWNG VVVHFRSCGG 101 VANTAPVFYHLGDTAEIAFT LDTLAARYRE IYAVGVSLGG NALAKYLGEQ 151 GENALPQAAA VISAPVDAEAAGNRFDSGIT RLLYTRYFLR TLIPKARSLQ 201 GFQTAFAAGC KTLGEFDDRF TAPLHGFADRHDYYRQTSCK PLLKHVAKPL 251 LLLNAVNDPF LPPEALPRAD EVSEAVTLFQ PTHGGHVGFVGSTGGRLHLQ 301 WLPQTVLSYF DSFRTNRR* a256-1/m256-1 95.6% identity in 318aa overlap         10        20        30        40        50        60a256-1.pep MILTPPDTPFFLRNGNADTIAAKFLQRSAPAYRRELLPDSTGKTKLAYDFSDGISPDAPL||||||||||||||||||||||||||| |||||||||||||||||:|||||||||||||| m256-1MILTPPDTPFFLRNGNADTIAAKFLQRPAPAYRRELLPDSTGKTKVAYDFSDGISPDAPL        10        20        30        40        50        60        70        80        90       100       110       120 a256-1.pepVVLFHGLEGGSGSHYAVELMLAVRDRGWNGVVVHFRSCGGVANTAPVFYHLGDTAEIAFT|||||||||:| ||||||||||||||||:|||||||||||:||||||||||||||||||| m256-1VVLFHGLEGSSRSHYAVELMLAVRDRGWHGVVVHFRSCGGIANTAPVFYHLGDTAEIAFT        70        80        90 100 110 120       130       140       150       160       170       180 a256-1.pepLDTLAARYREIYAVGVSLGGNALAKYLGEQGENALPQAAAVISAPVDAEAAGNRFDSGIT|||:|||||||||||||||||||||||||||::||||||||||||||||||| ||||||| m256-1LDTFAARYREIYAVGVSLGGNALAKYLGEQGKKALPQAAAVISAPVDAEAAGRRFDSGIT       130       140       150       160       170       180       190       200       210       220       230       240 a256-1.pepRLLYTRYFLRTLIPKARSLQGFQTAFAAGCKTLGEFDDRFTAPLHGFADRHDYYRQTSCK||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||| m256-1RLLYTRYFLRTLIPKAKSLQGFQTAFAAGCKTLGEFDDRFTAPLHGFADRHDYYRQTSCK       190       200       210       220       230       240       250       260       270       280       290       300 a256-1.pepPLLKHVAKPLLLLNAVNDPFLPPEALPRADEVSEAVTLFQPTHGGHVGFVGSTGGRLHLQ|||||||||||||||||||||||||||||||||||||||||::|||||||:||||||||| m256-1PLLKHVAKPLLLLNAVNDPFLPPEALPRADEVSEAVTLFQPAYGGHVGFVSSTGGRLHLQ       250       260       270       280       290       300       310      319 a256-1.pep WLPQTVLSYFDSFRTNRRX |||||||||||||||||||m256-1 WLPQTVLSYFDSFRTNRRX        310The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1017>:

g257.seq 1 atgggcaggc atttcgggcg cagacgtttt ctgacggctg ccgccgttgc 51tgtggccggt gcggcggttt cttttttgcc gaatcctttt gccgccggcg 101 gcgaaaaacgcaacatggat aaaaaacgcg atgaaaatgt gtttttctgg 151 aaaggtgtcg cgctgggttccggcgcggag ctgcgcctgt tcggcgtgga 201 cgacagacag gcggcggatt tggtcaataaggttttggcg gaagtggcgc 251 gtttggaaaa aatgttcagc ctttaccgtg aagacagcctgatcagccgt 301 ctgaaccgcg acggttatct gacttcgcct ccggcggatt ttttggaact351 gttgagcctg gccgcgatat tcacgcgctg aThis corresponds to the amino acid sequence <SEQ ID 1018; ORF 257.ng>:

g257.pep 1 MGRHFGRRRF LTAAAVAVAG AAVSFLPNPF AAGGEKRNMD KKRDENVFFW 51KGVALGSGAE LRLFGVDDRQ AADLVNKVLA EVARLEKMFS LYREDSLISR 101 LNRDGYLTSPPADFLELLSL AAIFTR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1019>:

m257.seq 1 ATGGGCAGGC ATTTCGGGCG .CAGCGTTTT CTGACGGTTG CCGCCGTTGC 51GGCGGGGaC. GCGGcGGTTT CTTTCCTGCC GAATCCTTTT GCCGCCGATG 101 ATGAAAAACGCAAcGGGGAT GAAAAACGCA ATGAAAATGT GTTTTTCTGG 151 AAAGGTGTCG CACTGGGTTCCGGTGCGGa. CTCCGTCTGT TCGGTGTGGA 201 CGACAGGCGT GCGGCGGATT TGGTCAACAAGGTTTTGGCG GAAGTGGCGC 251 GTTTGGAAAA ATTGTTCAGC CTTTACCGTG AAGACAGCCTGATCAGCCGC 301 CTGAACAGGG ACGGTTATCT GACTTCGCCG TCGGCGGATT TTTTGGAACT351 GkTGAGCCTG GCCGCGATAT TCACGCkCTG AThis corresponds to the amino acid sequence <SEQ ID 1020; ORF 257>:

m257.pep 1 MGRHFGXQRF LTVAAVAAGX AAVSFLPNPF AADDEKRNGD EKRNENVFFW 51KGVALGSGAX LRLFGVDDRR AADLVNKVLA EVARLEKLFS LYREDSLISR 101 LNRDGYLTSPSADFLELXSL AAIFTX*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 257 shows 88.0% identity over a 125 aa overlap with a predicted ORF(ORF 257.ng) from N. gonorrhoeae:

m257/g257         10        20        30        40        50        60m257.pep MGRHFGRQRFLTVAAVAAGTAAVSFLPNPFAADDEKRNGDEKRNENVFFWKGVALGSGAD|||||||:||||:||||:: ||||||||||||  |||| |:||:|||||||||||||||: g257MGRHFGRRRFLTAAAVAVAGAAVSFLPNPFAAGGEKRNMDKKRDENVFFWKGVALGSGAE        10        20        30        40        50        60        70        80        90       100       110       120 m257.pepLRLFGVDDRRAADLVNKVLAEVARLEKLFSLYREDSLISRLNRDGYLTSPSADFLELXSL|||||||||:|||||||||||||||||:|||||||||||||||||||||| |||||| || g257LRLFGVDDRQAADLVNKVLAEVARLEKMFSLYREDSLISRLNRDGYLTSPPADFLELLSL        70        80        90       100       110       120 m257.pepAAIFTXX ||||| | g257 AAIFTRXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1021>:

a257.seq 1 ATGGGCAGGC ATTTCGGGCG CAGGCGTTTT TTGACAGTTG CCGCCGTTGC 51GGCGGCGGGC GCGGCGGTTT CTTTCCTGCC GAATCCTTTT GCCGCCGATG 101ATGAAAAACG CAATAAAGAT GAAAAACGCA ATGAAAATGT GTTTTTCTGG 151AAAGGTGTCG CACTGGGTTC CGGTGCGGAG CTCCGTCTGT TCGGTGTGGA 201CGACAGGCGT GCGGCGGATT TGGTCAACAA GGTTTTGGCG GAAGTGGCGC 251GTTTGGAAAA AATGTTCAGC CTTTACCGTG AAGACAGCCT GATCAGCCGT 301CTGAACCGTG ACGGTTATTT GACTTCGCCG CCGGCGGATT TTTTGGAACT 351GTTGAGCCTG GCCGTGATAT TCACGCGCTG AThis corresponds to the amino acid sequence <SEQ ID 1022; ORF 257.a>:

a257.pep 1 MGRHFGRRRF LTVAAVAAAG AAVSFLPNPF AADDEKRNKD EKRNENVFFW 51KGVALGSGAE LRLFGVDDRR AADLVNKVLA EVARLEKMFS LYREDSLISR 101LNRDGYLTSP PADFLELLSL AVIFTR* n257/a257 92.0% identity in 125 aa overlap        10        20        30        40        50        60 m257.pepMGRHFGXQRFLTVAAVAAGXAAVSFLPNPFAADDEKRNGDEKRNENVFFWKGVALGSGAX ||||||:||||||||||: |||||||||||||||||| |||||||||||||||||||| a257MGRHFGRRRFLTVAAVAAAGAAVSFLPNPFAADDEKRNKDEKRNENVFFWKGVALGSGAE        10        20        30        40        50        60        70        80        90       100       110       120 m257.pepLRLFGVDDRRAADLVNKVLAEVARLEKLFSLYREDSLISRLNRDGYLTSPSADFLELXSL|||||||||||||||||||||||||||:|||||||||||||||||||||| |||||| || a257LRLFGVDDRRAADLVNKVLAEVARLEKMFSLYREDSLISRLNRDGYLTSPPADFLELLSL        70        80        90       100       110       120 m257.pepAAIFTXX |:||| a257 AVIFTRXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1023>:

g258.seq 1 atgcgccgct tcctaccgat cgcagccata tgcgccgtcg tcctgctgta 51cggattgacg gcggcgaccg gcagcaccag ttcgctggcg gattatttct 101ggtggatagt ctcgttcagc gcaatgctgc tgctggtgtt gtccgccgtt 151ttggcacgtt atgtcatatt gctgttgaaa gacaggcgca acggcgtgtt 201cggttcgcag attgccaaac gcctttccgg gatgttcacg ctggtcgccg 251tactgcccgg cttgttcctg ttcggcattt ccgcgcagtt tatcaacggc 301acgattaatt cgtggttcgg caacgacacc cacgaagccc tcgaacgcag 351ccttaatttg agcaagtccg cactggattt ggcggcagac aatgccgtca 401gcaacgccgt tcccgtacag atagacctca tcggcaccgc ctccctgtcg 451ggcaatatgg gcagtgtgct ggaacactac gccggcagcg gttttgccca 501gcttgccctg tacaatgccg caagcgggaa aatcgaaaaa agcatcaatc 551cgcaccaatt cgaccagccg cttcccgaca aagaacattg ggaacagatt 601cagcagaccg gttcggttcg gagtttggaa agcataggcg gcgtattgta 651cgcgcaggga tggttgtcgg caggtacgca caacgggcgc gattacgcgc 701tgttcttccg ccagccgatt cccgaaaatg tggcacagga tgccgttctg 751attgaaaagg cgcgggcgaa atatgccgaa ttgagttaca gcaaaaaagg 801tttgcagacc ttttttctgg taaccctgct gattgcctcg ctgctgtcga 851tttttcttgc gctggtaatg gcactgtatt ttgcccgccg tttcgtcgaa 901cccattctgt cgcttgccga gggcgcaaag gcggtggcgc agggtgattt 951cagccagacg cgccccgtat tgcgcaacga cgagttcgga cgtttgacca 1001agctgttcaa ccatatgacc gagcagcttt ccatcgccaa agaagcagac 1051gaacgcaacc gccggcgcga ggaagccgcc cgtcactacc tcgagtgcgt 1101gttggatggg ttgactaccg gtgtggtggt ctcntacccc ctctcttgtt 1151gccgtaccgc ggtgttttcc acttgtcatt cctcccctct ttcttatttc 1201 taaThis corresponds to the amino acid sequence <SEQ ID 1024; ORF 258.ng>:

g258.pep 1 MRRFLPIAAI CAVVLLYGLT AATGSTSSLA DYFWWIVSFS AMLLLVLSAV 51LARYVILLLK DRRNGVFGSQ IAKRLSGMFT LVAVLPGLFL FGISAQFING 101TINSWFGNDT HEALERSLNL SKSALDLAAD NAVSNAVPVQ IDLIGTASLS 151GNMGSVLEHY AGSGFAQLAL YNAASGKIEK SINPHQFDQP LPDKEHWEQI 201QQTGSVRSLE SIGGVLYAQG WLSAGTHNGR DYALFFRQPI PENVAQDAVL 251IEKARAKYAE LSYSKKGLQT FFLVTLLIAS LLSIFLALVM ALYFARRFVE 301PILSLAEGAK AVAQGDFSQT RPVLRNDEFG RLTKLFNHMT EQLSIAKEAD 351ERNRRREEAA RHYLECVLDG LTTGVVVSYP LSCCRTAVFS TCHSSPLSYF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1025>:

m258.seq 1 ATGCGCCGTT TTCTACCGAT CGCAGCCATA TGCGCCGTCG TCCTGTTGTA 51CGGACTGACG GCGGCAACCG GCAGCACCAG TTCGCTGGCG GATTATTTCT 101GGTGGATTGT TGCGTTCAGC GCAATGCTGC TGCTGGTGTT GTCCGCCGTT 151TTGGCACGTT ATGTCATATT GCTGTTGAAA GACAGGCGCG ACGGCGTATT 201CGGTTCGCAG ATTGCCAAAC GCCTTTCTGG GATGTTTACG CTGGTTGCCG 251TACTGCCCGG CGTGTTTCTG TTCGGCGTTT CCGCACAGTT CATCAACGGC 301ACGATTAATT CGTGGTTCGG CAACGATACC CACGAGGCGC TTGAACGCAG 351CCTCAATTTG AGCAAGTCCG CATTGAATTT GGCGGCAGAC AACGCCCTCG 401GCAACGCCGT CCCCGTGCAG ATAGACCTCA TCGGCGCGGC TTCCCTGCCC 451GGGGATATGG GCAGGGTGCT GGAACATTAC GCCGGCAGCG GTTTTGCCCA 501GCTTGCCCTG TACAATGCCG CAAGCGGCAA AATCGAAAAA AGCATCAACC 551CGCACAAGCT CGATCAGCCG TTTCCAGGTA AGGCGCGTTG GGAAAAAATC 601CAACGGGCGG GTTCGGTCAG GGATTTGGAA AGCATAGGCG GCGTATTGTA 651CGCGCAGGGC TGGCTGTCGG CGGGTACGCA CAACGGGCGC GATTACGCCT 701TGTTTTTCCG TCAGCCGGTT CCCAAAGGCG TGGCAGAGGA TGCCGTCTTA 751ATCGAAAAGG CAAGGGCGAA ATATGCTGAG TTGAGTTACA GCAAAAAAGG 801TTTGCAGACC TTTTTCCTGG CAACCCTGCT GATTGCCTCG CTGCTGTCGA 851TTTTTCTTGC ACTGGTCATG GCACTGTATT TCGCCCGCCG TTTCGTCGAA 901CCCGTCCTAT CGCTTGCCGA GGGGGCGAAG GCGGTGGCGC AAGGCGATTT 951CAGCCAGACG CGCCCCGTGT TGCGCAACGA CGAGTTCGGA CGCTTGACCA 1001AGTTGTTCAA CCACATGACC GAGCAGCTTT CCATCGCCAA AGAAGCAGAC 1051GAGCGCAACC GCCGGCGCGA GGAAGCCGCC AGGCATTATC TTGAATGCGT 1101GTTGGAGGGG CTGACCACGG GCGTGGTGGT GTTTGACGAA CAAGGCTGTC 1151TGAAAACsTT CAACAAAGCG GCGGAACAGA TTyTGGGGAT GCCGCTTACC 1201CCCcTGTGGG GCAGCAGCCG GCACGGTTGG CACGGCGTTT CGGCGCAGCA 1251GTCCCTGCTT GCCGAAGTGT TTGCCGCCAT CGGCGCGGCG GCAGGTACGG 1301ACAAACCGGT CCATGTGAAA TATGCCGCGC CGGACGATGC CAAAATCCTG 1351CTGGGCAAGG CAACCGTCCT GCCCGAAGAC AACGGCAACg GCGTGGTAAT 1401GGTGATTGAC GACATCACCG TTTTGATACA CGCGCAAAAA GAAGCCGCGT 1451GGGGCGAAgT GGCGaAgCGG CTGGCACACG AAATCCGCAA TCCGCTCACG 1501CCCATCCAGC TTTCCGCCGA ACgGsTGGCG TkGAAATTGG GCGGGAAGCT 1551GGATGAGCAG GATGCGCAAA TCCTGACGCG TTCGACCGAC ACCATCGTCA 1601AACAGGTGGC GGCATTGAAG GAAATGGTCG AAGCATTCCG CAATTATGCG 1651CGTTCCCCTT CGCTCAAATT GGAAAATCAG GATTTGAACG CCTTAATCGG 1701CGATGTGTTG GCATTGTATG AAGCCGGTCC GTGCCGGTTT GCGGCGGACT 1751TGCCGGCGAA CCGCTGAThis corresponds to the amino acid sequence <SEQ ID 1026; ORF 258>:

m258.pep 1 MRRFLPIAAI CAVVLLYGLT AATGSTSSLA DYFWWIVAFS AMLLLVLSAV 51LARYVILLLK DRRDGVFGSQ IAKRLSGMFT LVAVLPGVFL FGVSAQFING 101TINSWFGNDT HEALERSLNL SKSALNLAAD NALGNAVPVQ IDLIGAASLP 151GDMGRVLEHY AGSGFAQLAL YNAASGKIEK SINPHKLDQP FPGKARWEKI 201QRAGSVRDLE SIGGVLYAQG WLSAGTHNGR DYALFFRQPV PKGVAEDAVL 251IEKARAKYAE LSYSKKGLQT FFLATLLIAS LLSIFLALVM ALYFARRFVE 301PVLSLAEGAK AVAQGDFSQT RPVLRNDEFG RLTKLFNHMT EQLSIAKEAD 351ERNRRREEAA RHYLECVLEG LTTGVVVFDE QGCLKTFNKA AEQILGMPLT 401PLWGSSRHGW HGVSAQQSLL AEVFAAIGAA AGTDKPVHVK YAAPDDAKIL 451LGKATVLPED NGNGVVMVID DITVLIHAQK EAAWGEVAKR LAHEIRNPLT 501PIQLSAERXA XKLGGKLDEQ DAQILTRSTD TIVKQVAALK EMVEAFRNYA 551RSPSLKLENQ DLNALIGDVL ALYEAGPCRF AADLPANR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 258 shows 90.9% identity over a 386 aa overlap with a predicted ORF(ORF 258.ng) from N. gonorrhoeae:

m258/g258         10        20        30        40        50        60m258.pep MRRFLPIAAICAVVLLYGLTAATGSTSSLADYFWWIVAFSAMLLLVLSAVLARYVILLLK|||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||| g258MRRFLPIAAICAVVLLYGLTAATGSTSSLADYFWWIVSFSAMLLLVLSAVLARYVILLLK        10        20        30        40        50        60        70        80        90       100       110       120 m258.pepDRRDGVFGSQIAKRLSGMFTLVAVLPGVFLFGVSAQFINGTINSWFGNDTHEALERSLNL|||:|||||||||||||||||||||||:||||:||||||||||||||||||||||||||| g258DRRNGVFGSQIAKRLSGMFTLVAVLPGLFLFGISAQFINGTINSWFGNDTHEALERSLNL        70        80        90       100       110       120       130       140       150       160       170       180 m258.pepSKSALNLAADNALGNAVPVQIDLIGAASLPGDMGRVLEHYAGSGFAQLALYNAASGKIEK|||||:||||||::|||||||||||:||| |:|| ||||||||||||||||||||||||| g258SKSALDLAADNAVSNAVPVQIDLIGTASLSGNMGSVLEHYAGSGFAQLALYNAASGKIEK       130       140       150       160       170       180       190       200       210       220       230       240 m258.pepSINPHKLDQPFPGKARWEKIQRAGSVRDLESIGGVLYAQGWLSAGTHNGRDYALFFRQPV|||||::|||:| | :||:||::||||:|||||||||||||||||||||||||||||||: g258SINPHQFDQPLPDKEHWEQIQQTGSVRSLESIGGVLYAQGWLSAGTHNGRDYALFFRQPI       190       200       210       220       230       240       250       260       270       280       290       300 m258.pepPKGVAEDAVLIEKARAKYAELSYSKKGLQTFFLATLLIASLLSIFLALVMALYFARRFVE|::||:|||||||||||||||||||||||||||:|||||||||||||||||||||||||| g258PENVAQDAVLIEKARAKYAELSYSKKGLQTFFLVTLLIASLLSIFLALVMALYFARRFVE       250       260       270       280       290       300       310       320       330       340       350       360 m258.pepPVLSLAEGAKAVAQGDFSQTRPVLRNDEFGRLTKLFNHMTEQLSIAKEADERNRRREEAA|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g258PILSLAEGAKAVAQGDFSQTRPVLRNDEFGRLTKLFNHMTEQLSIAKEADERNRRREEAA       310       320       330       340       350       360       370       380       390       400       410       420 m258.pepRHYLECVLEGLTTGVVVFDEQGCLKTFNKAAEQILGMPLTPLWGSSRHGWHGVSAQQSLL||||||||:||||||||    :| :| g258RHYLECVLDGLTTGVVVSYPLSCCRTAVFSTCHSSPLSYFX       370       380       390       400The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1027>:

a258.seq 1 ATGCGCCGTT TTCTACCGAT CGCAGCCATA TGCGCCGTCG TCCTGTTGTA 51CGGACTGACG GCGGCAACCG GCAGCACCAG TTCGCTGGCG GATTATTTCT 101GGTGGATTGT TGCGTTCAGC GCAATGCTGC TGCTGGTGTT GTCCGCCGTT 151TTGGCACGTT ATGTCATATT GCTGTTGAAA GACAGGCGCG ACGGCGTATT 201CGGTTCGCAG ATTGCCAAAC GCCTTTCCGG GATGTTTACG CTGGTTGCCG 251TACTGCCCGG CGTGTTTCTG TTCGGCGTTT CCGCACAGTT TATCAACGGC 301ACGATTAATT CGTGGTTCGG CAACGATACC CACGAGGCGC TTGAACGCAG 351CCTCAATTTG AGCAAGTCCG CATTGAATCT GGCGGCAGAC AACGCCCTTG 401GCAACGCCAT CCCCGTGCAG ATAGACCTCA TCGGCGCGGC TTCCCTGCCC 451GGGGATATGG GCAGGGTGCT GGAACATTAC GCCGGCAGCG GTTTTGCCCA 501GCTTGCCCTG TACAATGCCG CAAGCGGCAA AATCGAAAAA AGCATCAACC 551CGCACAAGCT CGATCAGCCG TTTCCAGGTA AGGCGCGTTG GGAAAAAATC 601CAACAGGCGG GTTCGGTCAG GGATTTGGAA AGCATAGGCG GCGTATTGTA 651CGCGCAGGGC TGGCTGTCGG CAGGTACGCA CAACGGGCGC GATTACGCCT 701TGTTTTTCCG TCAGCCGGTT CCCAAAGGCG TGGCAGAGGA TGCCGTCTTA 751ATCGAAAAGG CAAGGGCGAA ATATGCTGAG TTGAGTTACA GCAAAAAAGG 801TTTGCAGACC TTTTTCCTGG CAACCCTGCT GATTGCCTCG CTGCTGTCGA 851TTTTTCTTGC ACTGGTCATG GCACTGTATT TCGCCCGCCG TTTCGTCGAA 901CCCGTCCTAT CGCTTGCCGA GGGGGCGAAG GCGGTGGCGC AAGGCGATTT 951CAGCCAGACG CGCCCCGTGT TGCGCAACGA CGAGTTCGGA CGCTTGACCA 1001AGTTGTTCAA CCACATGACC GAGCAGCTTT CCATCGCCAA AGAAGCAGAC 1051GAGCGCAACC GCCGGCGCGA GGAAGCCGCC AGACATTATC TCGAATGCGT 1101GTTGGAGGGG CTGACCACGG GCGTGGTGGT GTTTGACGAA CAAGGCTGTC 1151TGAAAACCTT CAACAAAGCG GCGGAACAGA TTTTGGGGAT GCCGCTTACC 1201CCCCTGTGGG GCAGCAGCCG GCACGGTTGG CACGGCGTTT CGGCGCAGCA 1251GTCCCTGCTT GCCGAAGTGT TTGCCGCCAT CGGCGCGGCG GCAGGTACGG 1301ACAAACCGGT CCATGTGAAA TATGCCGCGC CGGACGATGC CAAAATCCTG 1351CTGGGCAAGG CAACCGTCCT GCCCGAAGAC AACGGCAACG GCGTGGTAAT 1401GGTGATTGAC GACATCACCG TTTTGATACA CGCGCAAAAA GAAGCCGCGT 1451GGGGCGAAGT GGCAAAACGG CTGGCACACG AAATCCGCAA TCCGCTCACG 1501CCCATCCAGC TTTCTGCCGA ACGGCTGGCG TGGAAATTGG GCGGGAAGCT 1551GGACGAGCAG GACGCGCAAA TCCTGACACG TTCGACCGAC ACCATCATCA 1601AACAAGTGGC GGCATTAAAA GAAATGGTCG AGGCATTCCG CAATTACGCG 1651CGTTCCCCTT CGCTCAAATT GGAAAATCAG GATTTGAACG CCTTAATCGG 1701CGATGTGTTG GCATTGTACG AAGCTGGTCC GTGCCGGTTT GCGGCGGAAC 1751TTGCCGGCGA ACCGCTGATG ATGGCGGCGG ATACGACCGC CATGCGGCAG 1801GTGCTGCACA ATATTTTCAA AAATGCCGCC GAAGCGGCGG AAGAAGCCGA 1851TGTGCCCGAA GTCAGGGTAA AATCGGAAGC GGGGCAGGAC GGACGGATTG 1901TCCTGACAGT TTGCGACAAC GGCAAGGGGT TCGGCAGGGA AATGCTGCAC 1951AATGCCTTCG AGCCGTATGT AACGGACAAA CCGGCTGGAA CGGGATTGGG 2001ACTGCCCGTG GTGAAAAAAA TCATTGAAGA ACACGGCGGC CGCATCAGCC 2051TGAGCAATCA GGATGCGGGC GGCGCGTGTG TCAGAATCAT CTTGCCAAAA 2101ACGGTAGAAA CTTATGCGTA GThis corresponds to the amino acid sequence <SEQ ID 1028; ORF 258.a>:

a258.pep 1 MRRFLPIAAI CAVVLLYGLT AATGSTSSLA DYFWWIVAFS AMLLLVLSAV 51LARYVILLLK DRRDGVFGSQ IAKRLSGMFT LVAVLPGVFL FGVSAQFING 101TINSWFGNDT HEALERSLNL SKSALNLAAD NALGNAIPVQ IDLIGAASLP 151GDMGRVLEHY AGSGFAQLAL YNAASGKIEK SINPHKLDQP FPGKARWEKI 201QQAGSVRDLE SIGGVLYAQG WLSAGTHNGR DYALFFRQPV PKGVAEDAVL 251IEKARAKYAE LSYSKKGLQT FFLATLLIAS LLSIFLALVM ALYFARRFVE 301PVLSLAEGAK AVAQGDFSQT RPVLRNDEFG RLTKLFNHMT EQLSIAKEAD 351ERNRRREEAA RHYLECVLEG LTTGVVVFDE QGCLKTFNKA AEQILGMPLT 401PLWGSSRHGW HGVSAQQSLL AEVFAAIGAA AGTDKPVHVK YAAPDDAKIL 451LGKATVLPED NGNGVVMVID DITVLIHAQK EAAWGEVAKR LAHEIRNPLT 501PIQLSAERLA WKLGGKLDEQ DAQILTRSTD TIIKQVAALK EMVEAFRNYA 551RSPSLKLENQ DLNALIGDVL ALYEAGPCRF AAELAGEPLM MAADTTAMRQ 601VLHNIFKNAA EAAEEADVPE VRVKSEAGQD GRIVLTVCDN GKGFGREMLH 651NAFEPYVTDK PAGTGLGLPV VKKIIEEHGG RISLSNQDAG GACVRIILPK 701 TVETYA*m258/a258 99.0% identity in 584 aa overlap        10        20        30        40        50        60 m258.pepMRRFLPIAAICAVVLLYGLTAATGSTSSLADYFWWIVAFSAMLLLVLSAVLARYVILLLK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a258MRRFLPIAAICAVVLLYGLTAATGSTSSLADYFWWIVAFSAMLLLVLSAVLARYVILLLK        10        20        30        40        50        60        70        80        90       100       110       120 m258.pepDRRDGVFGSQIAKRLSGMFTLVAVLPGVFLFGVSAQFINGTINSWFGNDTHEALERSLNL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a258DRRDGVFGSQIAKRLSGMFTLVAVLPGVFLFGVSAQFINGTINSWFGNDTHEALERSLNL        70        80        90       100       110       120       130       140       150       160       170       180 m258.pepSKSALNLAADNALGNAVPVQIDLIGAASLPGDMGRVLEHYAGSGFAQLALYNAASGKIEK||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||| a258SKSALNLAADNALGNAIPVQIDLIGAASLPGDMGRVLEHYAGSGFAQLALYNAASGKIEK       130       140       150       160       170       180       190       200       210       220       230       240 m258.pepSINPHKLDQPFPGKARWEKIQRAGSVRDLESIGGVLYAQGWLSAGTHNGRDYALFFRQPV|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| a258SINPHKLDQPFPGKARWEKIQQAGSVRDLESIGGVLYAQGWLSAGTHNGRDYALFFRQPV       190       200       210       220       230       240       250       260       270       280       290       300 m258.pepPKGVAEDAVLIEKARAKYAELSYSKKGLQTFFLATLLIASLLSIFLALVMALYFARRFVE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a258PKGVAEDAVLIEKARAKYAELSYSKKGLQTFFLATLLIASLLSIFLALVMALYFARRFVE       250       260       270       280       290       300       310       320       330       340       350       360 m258.pepPVLSLAEGAKAVAQGDFSQTRPVLRNDEFGRLTKLFNHMTEQLSIAKEADERNRRREEAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a258PVLSLAEGAKAVAQGDFSQTRPVLRNDEFGRLTKLFNHMTEQLSIAKEADERNRRREEAA       310       320       330       340       350       360       370       380       390       400       410       420 m258.pepRHYLECVLEGLTTGVVVFDEQGCLKTFNKAAEQILGMPLTPLWGSSRHGWHGVSAQQSLL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a258RHYLECVLEGLTTGVVVFDEQGCLKTFNKAAEQILGMPLTPLWGSSRHGWHGVSAQQSLL       370       380       390       400       410       420       430       440       450       460       470       480 m258.pepAEVFAAIGAAAGTDKPVHVKYAAPDDAKILLGKATVLPEDNGNGVVMVIDDITVLIHAQK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a258AEVFAAIGAAAGTDKPVHVKYAAPDDAKILLGKATVLPEDNGNGVVMVIDDITVLIHAQK       430       440       450       460       470       480       490       500       510       520       530       540 m258.pepEAAWGEVAKRLAHEIRNPLTPIQLSAERXAXKLGGKLDEQDAQILTRSTDTIVKQVAALK|||||||||||||||||||||||||||| | |||||||||||||||||||||:||||||| a258EAAWGEVAKRLAHEIRNPLTPIQLSAERLAWKLGGKLDEQDAQILTRSTDTIIKQVAALK       490       500       510       520       530       540       550       560       570       580      589 m258.pepEMVEAFRNYARSPSLKLENQDLNALIGDVLALYEAGPCRFAADLPANRX||||||||||||||||||||||||||||||||||||||||||:| a258EMVEAFRNYARSPSLKLENQDLNALIGDVLALYEAGPCRFAAELAGEPLMMAADTTAMRQ       550       560       570       580       590       600 a258VLHNIFKNAAEAAEEADVPEVRVKSEAGQDGRIVLTVCDNGKGFGREMLHNAFEPYVTDK       610       620       630       640       650       660The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1029>:

g259.seq 1 atgatgatgc acgcttctgt ccaaagtcgt ttcgcaccga tactttatgt 51tttgattttc tttgccggtt ttttgaccgc gcaaatctgg ttcaatcaga 101aagcctatac tgaagagctg cctccgcttc tgtccgcatt gtccgccgtc 151gcgctggtgt ggctggcgtg ggcgttcgtg tcggtgcgtt caaaggctaa 201ggcagaaaag ttctaccgcg aaaaaatgat acagaacgaa agcatacacc 251ccgtcctgca cgcttctttg caacacttgg aacacaagcc gcaaatgctc 301gccctgctgg tcaaaaacca cggcaaaggc atggcggaac aggtcaggtt 351caaggcggaa gtgctgcccg acgacgaaga cgcgcgcacg attgccgccg 401agttggcaaa aatggatatg ttcgcattgg ggacggacgc ggtcgcctcg 451ggcgaaacct atgggcgcgt gttcgccgat attttcgagt tgtcggcggc 501tttggaaagg cgcgcgttca aagggatact gaaactgacg gcggaatata 551aaaaacatct tcggcgatgc ctgccgttcg gaaacggcgt tggatttggg 601cgcgctcaat caggcgttga gggaaatctc gaaaacgccg gaaaagccta 651 aThis corresponds to the amino acid sequence <SEQ ID 1030; ORF 259.ng>:

g259.pep 1 MMMHASVQSR FAPILYVLIF FAGFLTAQIW FNQKAYTEEL PPLLSALSAV 51ALVWLAWAFV SVRSKAKAEK FYREKMIQNE SIHPVLHASL QHLEHKPQML 101ALLVKNHGKG MAEQVRFKAE VLPDDEDART IAAELAKMDM FALGTDAVAS 151GETYGRVFAD IFELSAALER RAFKGILKLT AEYKKHLRRC LPFGNGVGFG 201RAQSGVEGNL ENAGKA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1031>:

m259.seq (partial) 1ATGATGATGC ACGCTTCTGT CCAAAGCCGT TTCGCACCGA TACTTTATGT 51TTTGATTTTC TTTGCCGGTT TTTTGACCGC GCAAATCTGG TTCAATCAGA 101AAGCCTATAC TGAAGAGCTG CCTCCGCTTC TGTCCGCATT GTCCGCCGTC 151GCGCTGGTGT GGCTGGCGTG GGCGTTCGTG TCGGCGCGTT CAAAGGCCAA 201GGCGGAAAAG TTCTACCGCG AAAAAATGAT ACAGAACGAA AGCATACACC 251CCGTCsTGCA CGCCTCTTTG CAACACTTGG AACACAAGCC GCAAATACTC 301GCCCTGCTGG TCAAAAACCA CGGCAAAGGG ATGGCGGAAC AGGTCAGGTT 351CAAGGCGGAA GTGCTGCCCG ACGACGAAGA CGCGCGCACG ATTGCCGCCG 401AGTTGGCAAA AATGGATATG TTCGCATTGG GGACkGACGC GGTCGCCTCG 451GGCGAAACCT ATGGACGCGT GTTCGCCGAT ATTTTCGAGT TGTCGGmGGC 501TTTGGAAGGG CGCGCGTTCA AAGGAATGTT GAAACTGACG GCGGAATATA 551AA.AACATCT TCGGmGATGC CTGCCGTTCG GAAACGGCGT TGGAGTTGGG 601CGCACTCAAT CAGGCGTTGC AGGAGATTTC AAAAACATCC GG..This corresponds to the amino acid sequence <SEQ ID 1032; ORF 259>:

m259.pep (partial) 1MMMHASVQSR FAPILYVLIF FAGFLTAQIW FNQKAYTEEL PPLLSALSAV 51ALVWLAWAFV SARSKAKAEK FYREKMIQNE SIHPVXHASL QHLEHKPQIL 101ALLVKNHGKG MAEQVRFKAE VLPDDEDART IAAELAKMDM FALGTDAVAS 151GETYGRVFAD IFELSXALEG RAFKGMLKLT AEYKXHLRRC LPFGNGVGVG 201RTQSGVAGDF KNIR..Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 259 shows 94.3% identity over a 212 aa overlap with a predicted ORF(ORF 259.ng) from N. gonorrhoeae:

m259/g259         10       20       30       40       50       60m259.pep MMMHASVQSRFAPILYVLIFFAGFLTAQIWFNQKAYTEELPPLLSALSAVALVWLAWAFV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g259MMMHASVQSRFAPILYVLIFFAGFLTAQIWFNQKAYTEELPPLLSALSAVALVWLAWAFV        10        20        30        40        50        60        70        80        90       100       110       120 m259.pepSARSKAKAEKFYREKMIQNESIHPVXHASLQHLEHKPQILALLVKNHGKGMAEQVRFKAE|:||||||||||||||||||||||| ||||||||||||:||||||||||||||||||||| g259SVRSKAKAEKFYREKMIQNESIHPVLHASLQHLEHKPQMLALLVKNHGKGMAEQVRFKAE        70        80        90       100       110       120       130       140       150       160       170       180 m259.pepVLPDDEDARTIAAELAKMDMFALGTDAVASGETYGRVFADIFELSXALEGRAFKGMLKLT||||||||||||||||||||||||||||||||||||||||||||| ||| |||||:|||| g259VLPDDEDARTIAAELAKMDMFALGTDAVASGETYGRVFADIFELSAALERRAFKGILKLT       130       140       150       160       170       180       190       200       210 m259.pepAEYKKHLRRCLPFGNGVGVGRTQSGVAGDFKNIR |||||||||||||||||| ||:|||| |:::| g259AEYKKHLRRCLPFGNGVGFGRAQSGVEGNLENAGKAX        190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1033>:

a259.seq (partial) 1ATGATGATGC ACGCTTCTGT CCAAAGCCGT TTCGCACCGA TACTTTATGT 51TTTGATTTTC TTTGCCGGTT TTTTGACCGC GCAAATCTGG TTCAATCAGA 101AAGCCTATAC TGAAGAGCTG CCTCCGCTTC TGTCCGCATT GTCCGCCGTC 151GCGCTGGTGT GGCTGGCGTG GGCGTTCGTG TCGGCGCGTT CAAAGGCTAA 201GGCGGAAAAG TTCTACCGCG AAAAAATGAT ACAGAACGAA AGCATACACC 251CCGTCCTGCA CGCTTCTTTG CAACACTTGG AACACAAGCC GCAAATGCTC 301GCCCTGCTGG TCAAAAACCA CGGCAAAGGG ATGGCGGAAC AGGTCAGGTT 351CAAGGCGGAA GTGCTGCCCG ACGACGAAGA CGCGCGCACG ATTGCCGCCG 401AGTTGGCAAA AATGGATATG TTTGCATTGG GGACGGACGC GGTCGCCTCG 451GGCGAAACCT ATGGACGCGT GTTCGCCGAT ATTTTCGAGT TGTCGGCGGC 501TTTGGAAGGG CGCGCGTTCA AAGGAATGTT GAAACTGACG GCGGAATATA 551AAAA.CATCT TCGGCGATGC CTGCCGTTCG GAAACGGCGT TGGAGTTGGG 601CGCGCTCAAT CAGGCGTTGC AGGAGATTTC AAAAACATCG GAAAAGTCCA 651 AThis corresponds to the amino acid sequence <SEQ ID 1034; ORF 259.a>:

a259.pep (partial) 1 MMMHASVQSR FAPILYVLIF FAGFLTAQIW FNQKAYTEELPPLLSALSAV 51 ALVWLAWAFV SARSKAKAEK FYREKMIQNE SIHPVLHASL QHLEHKPQML 101ALLVKNHGKG MAEQVRFKAE VLPDDEDART IAAELAKMDM FALGTDAVAS 151 GETYGRVFADIFELSAALEG RAFKGMLKLT AEYKXHLRRC LPFGNGVGVG 201 RAQSGVAGDF KNIGKVQm259/a259 98.1% identity in 213 aa overlap        10        20        30        40        50        60 m259.pepMMMHASVQSRFAPILYVLIFFAGFLTAQIWFNQKAYTEELPPLLSALSAVALVWLAWAFV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a259MMMHASVQSRFAPILYVLIFFAGFLTAQIWFNQKAYTEELPPLLSALSAVALVWLAWAFV        10        20        30        40        50        60        70        80        90       100       110       120 m259.pepSARSKAKAEKFYREKMIQNESIHPVXHASLQHLEHKPQILALLVKNHGKGMAEQVRFKAE||||||||||||||||||||||||| ||||||||||||:||||||||||||||||||||| a259SARSKAKAEKFYREKMIQNESIHPVLHASLQHLEHKPQMLALLVKNHGKGMAEQVRFKAE        70        80        90       100       110       120       130       140       150       160       170       180 m259.pepVLPDDEDARTIAAELAKMDMFALGTDAVASGETYGRVFADIFELSXALEGRAFKGMLKLT||||||||||||||||||||||||||||||||||||||||||||| |||||||||||||| a259VLPDDEDARTIAAELAKMDMFALGTDAVASGETYGRVFADIFELSAALEGRAFKGMLKLT       130       140       150       160       170       180       190       200       210 m259.pepAEYKXHLRRCLPFGNGVGVGRTQSGVAGDFKNIR |||||||||||||||||||||:|||||||||||a259 AEYKXHLRRCLPFGNGVGVGRAQSGVAGDFKNIGKVQ       190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1035>:

g259-1.seq 1 ATGATGATGC ACGCTTCTGT CCAAAGTCGT TTCGCACCGA TACTTTATGT 51TTTGATTTTC TTTGCCGGTT TTTTGACCGC GCAAATCTGG TTCAATCAGA 101 AAGCCTATACTGAAGAGCTG CCTCCGCTTC TGTCCGCATT GTCCGCCGTC 151 GCGCTGGTGT GGCTGGCGTGGGCGTTCGTG TCGGTGCGTT CAAAGGCTAA 201 GGCAGAAAAG TTCTACCGCG AAAAAATGATACAGAACGAA AGCATACACC 251 CCGTCCTGCA CGCTTCTTTG CAACACTTGG AACACAAGCCGCAAATGCTC 301 GCCCTGCTGG TCAAAAACCA CGGCAAAGGC ATGGCGGAAC AGGTCAGGTT351 CAAGGCGGAA GTGCTGCCCG ACGACGAAGA CGCGCGCACG ATTGCCGCCG 401AGTTGGCAAA AATGGATATG TTCGCATTGG GGACGGACGC GGTCGCCTCG 451 GGCGAAACCTATGGGCGCGT GTTCGCCGAT ATTTTCGAGT TGTCGGCGGC 501 TTTGGAAThis corresponds to the amino acid sequence <SEQ ID 1036; ORF 259-1.ng>:

g259-1.pep 1 MMMHASVQSR FAPILYVLIF FAGFLTAQIW FNQKAYTEEL PPLLSALSAV 51ALVWLAWAFV SVRSKAKAEK FYREKMIQNE SIHPVLHASL QHLEHKPQML 101 ALLVKNHGKGMAEQVRFKAE VLPDDEDART IAAELAKMDM FALGTDAVAS 151 GETYGRVFAD IFELSAALEThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1037>:

m259-1.seq 1 ATGATGATGC ACGCTTCTGT CCAAAGCCGT TTCGCACCGA TACTTTATGT 51TTTGATTTTC TTTGCCGGTT TTTTGACCGC GCAAATCTGG TTCAATCAGA 101 AAGCCTATACTGAAGAGCTG CCTCCGCTTC TGTCCGCATT GTCCGCCGTC 151 GCGCTGGTGT GGCTGGCGTGGGCGTTCGTG TCGGCGCGTT CAAAGGCCAA 201 GGCGGAAAAG TTCTACCGCG AAAAAATGATACAGAACGAA AGCATACACC 251 CCGTCCTGCA CGCCTCTTTG CAACACTTGG AACACAAGCCGCAAATACTC 301 GCCCTGCTGG TCAAAAACCA CGGCAAAGGG ATGGCGGAAC AGGTCAGGTT351 CAAGGCGGAA GTGCTGCCCG ACGACGAAGA CGCGCGCACG ATTGCCGCCG 401AGTTGGCAAA AATGGATATG TTCGCATTGG GGACGGACGC GGTCGCCTCG 451 GGCGAAACCTATGGACGCGT GTTCGCCGAT ATTTTCGAGT TGTCGGCGGC 501 TTTGGAAGGG CGCGCGTTCAAAGGAATGTT GAAACTGACG GCGGAATATA 551 AAAACATCTT CGGCGATGCC TGCCGTTCGGAAACGGCGTT GGAGTTGGGC 601 GCACTCAATC AGGCGTTGCA GGAGATTTCA AAAACATCGGAAAAGTCCAA 651 ACGGATATTT TATTGAThis corresponds to the amino acid sequence <SEQ ID 1038; ORF 259-1>:

m259-1.pep 1 MMMHASVQSR FAPILYVLIF FAGFLTAQIW FNQKAYTEEL PPLLSALSAV 51ALVWLAWAFV SARSKAKAEK FYREKMIQNE SIHPVLHASL QHLEHKPQIL 101 ALLVKNHGKGMAEQVRFKAE VLPDDEDART IAAELAKMDM FALGTDAVAS 151 GETYGRVFAD IFELSAALEGRAFKGMLKLT AEYKNIFGDA CRSETALELG 201 ALNQALQEIS KTSEKSKRIF Y*g259-1/m259-1 98.8% identity in 169 aa overlap        10        20        30        40        50        60 g259-1.pepMMMHASVQSRFAPILYVLIFFAGFLTAQIWFNQKAYTEELPPLLSALSAVALVWLAWAFV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m259-1MMMHASVQSRFAPILYVLIFFAGFLTAQIWFNQKAYTEELPPLLSALSAVALVWLAWAFV        10        20        30        40        50        60        70        80        90       100       110       120 g259-1.pepSVRSKAKAEKFYREKMIQNESIHPVLHASLQHLEHKPQMLALLVKNHGKGMAEQVRFKAE|:||||||||||||||||||||||||||||||||||||:||||||||||||||||||||| m259-1SARSKAKAEKFYREKMIQNESIHPVLHASLQHLEHKPQILALLVKNHGKGMAEQVRFKAE        70        80        90       100       110       120       130       140       150       160      169 g259-1.pepVLPDDEDARTIAAELAKMDMFALGTDAVASGETYGRVFADIFELSAALE||||||||||||||||||||||||||||||||||||||||||||||||| m259-1VLPDDEDARTIAAELAKMDMFALGTDAVASGETYGRVFADIFELSAALEGRAFKGMLKLT       130       140       150       160       170       180The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1039>:

a259-1.seq 1 ATGATGATGC ACGCTTCTGT CCAAAGCCGT TTCGCACCGA TACTTTATGT 51TTTGATTTTC TTTGCCGGTT TTTTGACCGC GCAAATCTGG TTCAATCAGA 101 AAGCCTATACTGAAGAGCTG CCTCCGCTTC TGTCCGCATT GTCCGCCGTC 151 GCGCTGGTGT GGCTGGCGTGGGCGTTCGTG TCGGCGCGTT CAAAGGCTAA 201 GGCGGAAAAG TTCTACCGCG AAAAAATGATACAGAACGAA AGCATACACC 251 CCGTCCTGCA CGCTTCTTTG CAACACTTGG AACACAAGCCGCAAATGCTC 301 GCCCTGCTGG TCAAAAACCA CGGCAAAGGG ATGGCGGAAC AGGTCAGGTT351 CAAGGCGGAA GTGCTGCCCG ACGACGAAGA CGCGCGCACG ATTGCCGCCG 401AGTTGGCAAA AATGGATATG TTTGCATTGG GGACGGACGC GGTCGCCTCG 451 GGCGAAACCTATGGACGCGT GTTCGCCGAT ATTTTCGAGT TGTCGGCGGC 501 TTTGGAAGGG CGCGCGTTCAAAGGAATGTT GAAACTGACG GCGGAATATA 551 AAAACATCTT CGGCGATGCC TGCCGTTCGGAAACGGCGTT GGAGTTGGGC 601 GCGCTCAATC AGGCGTTGCA GGAGATTTCA AAAACATCGGAAAAGTCCAA 651 ACGGATATTT TATTGAThis corresponds to the amino acid sequence <SEQ ID 1040; ORF 259-1.a>:

a259-1.pep 1 MMMHASVQSR FAPILYVLIF FAGFLTAQIW FNQKAYTEEL PPLLSALSAV 51ALVWLAWAFV SARSKAKAEK FYREKMIQNE SIHPVLHASL QHLEHKPQML 101 ALLVKNHGKGMAEQVRFKAE VLPDDEDART IAAELAKMDM FALGTDAVAS 151 GETYGRVFAD IFELSAALEGRAFKGMLKLT AEYKNIFGDA CRSETALELG 201 ALNQALQEIS KTSEKSKRIF Y*a259-1/m259-1 99.5% identity in 221 aa overlap        10        20        30        40        50        60 a259-1.pepMMMHASVQSRFAPILYVLIFFAGFLTAQIWFNQKAYTEELPPLLSALSAVALVWLAWAFV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m259-1MMMHASVQSRFAPILYVLIFFAGFLTAQIWFNQKAYTEELPPLLSALSAVALVWLAWAFV        10        20        30        40        50        60        70        80        90       100       110       120 a259-1.pepSARSKAKAEKFYREKMIQNESIHPVLHASLQHLEHKPQMLALLVKNHGKGMAEQVRFKAE||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||| m259-1SARSKAKAEKFYREKMIQNESIHPVLHASLQHLEHKPQILALLVKNHGKGMAEQVRFKAE        70        80        90       100       110       120       130       140       150       160       170       180 a259-1.pepVLPDDEDARTIAAELAKMDMFALGTDAVASGETYGRVFADIFELSAALEGRAFKGMLKLT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m259-1VLPDDEDARTIAAELAKMDMFALGTDAVASGETYGRVFADIFELSAALEGRAFKGMLKLT       130       140       150       160       170       180       190       200       210       220 a259-1.pepAEYKNIFGDACRSETALELGALNQALQEISKTSEKSKRIFYX|||||||||||||||||||||||||||||||||||||||||| m259-1AEYKNIFGDACRSETALELGALNQALQEISKTSEKSKRIFYX       190       200       210       220The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1041>:

g260.seq 1 atgggtgcgg gtgtagtatt cgttgtcttt cagccgttct tcagcctgtt 51tcgagcgttg ttcgagggcg gagtcggtat agtcgaggga gcgcacgatg 101 ccgctgaatgcgacttcttg tccgaggaat ttacccgtat ccggatcggt 151 gatgttttta ttgattcggtaggtcagata acggcccggt tctttcaggc 201 ctttggtgta aaccctggcg cctttggtgtacagcagcct gccttccggg 251 cccgagagca ggcgcggcgc ggcagcggtt tctttgcgggaaacgatttg 301 cgggtgctgc ataaagacgc ggtagaagtt gacatcgatg gcgggaatac351 cgtatccgga cacttcctta tccggactga ttttgacgac ggggatgccg 401tctgtctgtt ccaagccgag gcgcggttcg ccgccaacgt agcgcaacac 451 caatacctggcccggataaa tcaggtcggg attgtggatt tgatcccggt 501 tcgcgcccca cagggggggaccattgccac gggctgtaca ggtatttgcc 551 cgaaataccc cacagggtgt cgccctgttt gaThis corresponds to the amino acid sequence <SEQ ID 1042; ORF 260.ng>:

g260.pep 1 MGAGVVFVVF QPFFSLFRAL FEGGVGIVEG AHDAAECDFL SEEFTRIRIG 51DVFIDSVGQI TARFFQAFGV NPGAFGVQQP AFRAREQARR GSGFFAGNDL 101 RVLHKDAVEVDIDGGNTVSG HFLIRTDFDD GDAVCLFQAE ARFAANVAQH 151 QYLARINQVG IVDLIPVRAPQGGTIATGCT GICPKYPTGC RPV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1043>:

m260.seq 1 ATGGGTGCGG GTATGGTATT CGTTGTCTTT CGGCCGTTCT CCAGCCTGTT 51TCGAGCGTTG TTCGAGGACA GAGTCGGTAT AGTCGAGGGA GCGCACGATG 101 CCGCTGAATGCGACTTCCTG CCCGAGGAAT TTACCCGTAT CCGGATCGGT 151 GATGTTTTTA TTGATTCGGTAGGTCAGGTA GCGGCCCGGC TCTTTCAGGC 201 CTTTGGTGTA AACCCTGGTG CCTTTGGTGTACAGCAGCCT GCCTTCCGGG 251 CCCGAGwrCA sGCGCGGyGC GGCAGCGGTT TCTTTGCGGGAAACGATTTG 301 CGGATGCCGC ATAAAGATGC GGTAGAAGTT GACATCGATG GCGGGAATAC351 CGTATCCGGA CACTTCCTTA TCCGGACTCA TTTTGACGAC GGGGATGCCG 401TCTGTCTGTT CCAAGCCGAG GCGCGGTTCG CCGTCAACGT GGCGCAACAC 451 CAATACCTGGTCCGGATAAA TCAGGTCGGG ATTGTGGATT TGATCCCGGT 501 TCGCGTyCCA CAGThis corresponds to the amino acid sequence <SEQ ID 1044; ORF 260>:

m260.pep 1 MGAGMVFVVF RPFSSLFRAL FEDRVGIVEG AHDAAECDFL PEEFTRIRIG 51DVFIDSVGQV AARLFQAFGV NPGAFGVQQP AFRARXXARX GSGFFAGNDL 101 RMPHKDAVEVDIDGGNTVSG HFLIRTHFDD GDAVCLFQAE ARFAVNVAQH 151 QYLVRINQVG IVDLIPVRVP QComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 260 shows 89.5% identity over a 171 aa overlap with a predicted ORF(ORF 260.ng) from N. gonorrhoeae:

m260/g260         10        20        30        40        50        60m260.pep MGAGMVFVVFRPFSSLFRALFEDRVGIVEGAHDAAECDFLPEEFTRIRIGDVFIDSVGQV||||:|||||:|| ||||||||  |||||||||||||||| ||||||||||||||||||: g260MGAGVVFVVFQPFFSLFRALFEGGVGIVEGAHDAAECDFLSEEFTRIRIGDVFIDSVGQI        10        20        30        40        50        60        70        80        90       100       110       120 m260.pepAARLFQAFGVNPGAFGVQQPAFRARXXARXGSGFFAGNDLRMPHKDAVEVDIDGGNTVSG:||:|||||||||||||||||||||  || |||||||||||: ||||||||||||||||| g260TARFFQAFGVNPGAFGVQQPAFRAREQARRGSGFFAGNDLRVLHKDAVEVDIDGGNTVSG        70        80        90       100       110       120       130       140       150       160       170 m260.pepHFLIRTHFDDGDAVCLFQAEARFAVNVAQHQYLVRINQVGIVDLIPVRVPQ|||||| |||||||||||||||||:||||||||:||||||||||||||:|| g260HFLIRTDFDDGDAVCLFQAEARFAANVAQHQYLARINQVGIVDLIPVRAPQGGTIATGCT       130       140       150       160       170       180 g260GICPKYPTGCRPV        190The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1045>:

a260.seq 1 ATGGGTGCGG GTATGGTATT CGTTGTCTTT CGGCCGTTCT CCAGCCTGTT 51TCGAGCGTTG TTCGAGGACA GAGTCGGTAT AGTCGAGGGA GCGCACGATG 101 CCGCTGAATGCGACTTCCTG CCCGAGGAAT TTACCCGTAT CCGGATCGGT 151 GATGTTTTTA TTGATTCGGTAGGTCAGGTA GCGGCCCGGC TCTTTCAGGC 201 CTTTGGTGTA AACCCTGGTG CCTTTGGTGTACAGCAGCCT GCCTTCCGGG 251 CCCGAGAGCA GGCGCGGCGC GGCAGCGGTT TCTTTGCGGGAAACGATTTG 301 CGGGTGCCGC ATAAAGATGC GGTAGAAGTT GACATCGATG GCGGGAATAC351 CGTATCCGGA CACTTCCTTA TCCGGACTCA TTTTGACGAC GGGGATGCCG 401TCTGTCTGTT CCAAGCCGAG GCGCGGTTCG CCGTCAACGT GGCGCAACAC 451 CAATACCTGGTCCAGATAAA TCAGGTCGGG ATTGTGGATT TGATCCCGGT 501 TCGCGTCCCA CAGGCGGCC.CCATTGCCAC GGGCTGTACA GGTATTTGCC 551 CGAAATGCCC CACAGGGTGT CGCCCTGTTT GAThis corresponds to the amino acid sequence <SEQ ID 1046; ORF 260.a>:

a260.pep 1 MGAGMVFVVF RPFSSLFRAL FEDRVGIVEG AHDAAECDFL PEEFTRIRIG 51DVFIDSVGQV AARLFQAFGV NPGAFGVQQP AFRAREQARR GSGFFAGNDL 101 RVPHKDAVEVDIDGGNTVSG HFLIRTHFDD GDAVCLFQAE ARFAVNVAQH 151 QYLVQINQVG IVDLIPVRVPQAAXIATGCT GICPKCPTGC RPV* m260/a260 97.1% identity in 171 aa overlap        10        20        30        40        50        60 m260.pepMGAGMVFVVFRPFSSLFRALFEDRVGIVEGAHDAAECDFLPEEFTRIRIGDVFIDSVGQV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a260MGAGMVFVVFRPFSSLFRALFEDRVGIVEGAHDAAECDFLPEEFTRIRIGDVFIDSVGQV        10        20        30        40        50        60        70        80        90       100       110       120 m260.pepAARLFQAFGVNPGAFGVQQPAFRARXXARXGSGFFAGNDLRMPHKDAVEVDIDGGNTVSG|||||||||||||||||||||||||  || |||||||||||:|||||||||||||||||| a260AARLFQAFGVNPGAFGVQQPAFRAREQARRGSGFFAGNDLRVPHKDAVEVDIDGGNTVSG        70        80        90       100       110       120       130       140       150       160       170 m260.pepHFLIRTHFDDGDAVCLFQAEARFAVNVAQHQYLVRINQVGIVDLIPVRVPQ||||||||||||||||||||||||||||||||||:|||||||||||||||| a260HFLIRTHFDDGDAVCLFQAEARFAVNVAQHQYLVQINQVGIVDLIPVRVPQAAXIATGCT       130       140       150       160       170       180 a260GICPKCPTGCRPVX        190The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1047>:

g261.seq 1 atggagcttg ggcatatcgt attccttgtg ctttgcgcgc gttcagacgg 51cctttttact ttccagacat tccgccagcc cgcgttcgcg caagatacag 101 ctcgggcattcgcggcagcc gccgacgata cccttgtagc aggtgtgggt 151 ctgttcgcgg atgtagtccaacacgcccat ttcgtccgcc aacgcccacg 201 tttgcgcctt ggtcaggtac atcagcggcgtgtggatttg aaaatcgtag 251 tccatcgcca gattaagggt aacgttcatg gatttgacgaacacgccgcg 301 gcagtcggga tagcccgaaa aatcggtttc gcacacgccc gcgatgatgt351 gccggatacc ctgccctttg gcaaaaatgg cggcgtaaag caggaaaagc 401gcgttacgcc cgtccacaaa ggtattggga acgccgttgt cggcggtttc 451 gatggcggcggtttcgatgg cggcggtttc gtccatcagg gcgttgtgcg 501 taatctgccg catcaggctcaaatcgagta cggtttgact gacacccaaa 551 tcctgcgcga tccactctgc gcgttccagctcgacggcat ggcgttgccc 601 gtatcggaag gtgatggctt ggacgttttc gcgcccgtaggtttggattg 651 cctgaatcag gcaggtggtc gaatcctgac cgcccgagaa gatgaccaag701 gctttttggt ttgaThis corresponds to the amino acid sequence <SEQ ID 1048; ORF 261.ng>:

g261.pep 1 MELGHIVFLV LCARSDGLFT FQTFRQPAFA QDTARAFAAA ADDTLVAGVG 51LFADVVQHAH FVRQRPRLRL GQVHQRRVDL KIVVHRQIKG NVHGFDEHAA 101 AVGIARKIGFAHARDDVPDT LPFGKNGGVK QEKRVTPVHK GIGNAVVGGF 151 DGGGFDGGGF VHQGVVRNLPHQAQIEYGLT DTQILRDPLC AFQLDGMALP 201 VSEGDGLDVF APVGLDCLNQ AGGRILTAREDDQGFLV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1049>:

m261.seq 1 ATGGAGCTTG GGCATATCGT ATTCCTTATG GTTTGCGCGT GTTCAGACGG 51CCTTTTTACT TTCCAGATAT TCCGCCAGCC cGcGTTCGCG CAAGATACAG 101 CTCGGGCATTCGCGgCAGCC GCCGACGATG CCGTTATAGC AGGTGTGGGT 151 TTGCTCGCGG ATATAGTCCAGCACGCCCAT TTCGTCCGCC AACGCCCACG 201 TTTGCGCCTT GGTCAGATAC ATCAGCGGCGTGTGGATTTG AAAATCATAG 251 TCCATCGCCA AATTAAGGGT AACGTTCATC GATTTGACAAACACGTCGCG 301 GCAGTCGGGA TAGCCGGAGA AGTCGGTTTC GCACACGCCC GCGATGATGT351 GCCGTATCCC CTGCCCTTTG GCGTAAATCG CGGCATAGAG CAGGAAAAGC 401gCGTTGCGGC CGTCTACAAA GGTATTCGGA ACGCCGTTTT CGGCAGTTTC 451 GATGGCGGCGGTGTCGTCCA TCAGGGCATT GTGCGTAATC TGCCGCATCA 501 GgCTcAAGTC GAGTACGGTTTGTTTGACGC CCAAATCCTG CGCAATCCAG 551 CGGGCACGTT CCAGCTCGAC GGCATGGCGTTGCCCGTATT GGAAAGTAAT 601 GGCTTGGACG TTTTCGCGCC CGTAGGTTTG GATTGCCTGAATCAGGCAGG 651 TGGTCGAATC CTGACCGCCC GAAAAGATGA CCAAGGCTTG TTGGTTTGAThis corresponds to the amino acid sequence <SEQ ID 1050; ORF 261>:

m261.pep 1 MELGHIVFLM VCACSDGLFT FQIFRQPAFA QDTARAFAAA ADDAVIAGVG 51LLADIVQHAH FVRQRPRLRL GQIHQRRVDL KIIVHRQIKG NVHRFDKHVA 101 AVGIAGEVGFAHARDDVPYP LPFGVNRGIE QEKRVAAVYK GIRNAVFGSF 151 DGGGVVHQGI VRNLPHQAQVEYGLFDAQIL RNPAGTFQLD GMALPVLESN 201 GLDVFAPVGL DCLNQAGGRI LTARKDDQGLLV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 261 shows 79.7% identity over a 237 aa overlap with a predicted ORF(ORF 261.ng) from N. gonorrhoeae:

m261/g261         10        20        30        40        50        60m261.pep MELGHIVFLMVCACSDGLFTFQIFRQPAFAQDTARAFAAAADDAVIAGVGLLADIVQHAH|||||||||::|| |||||||| ||||||||||||||||||||:::|||||:||:||||| g261MELGHIVFLVLCARSDGLFTFQTFRQPAFAQDTARAFAAAADDTLVAGVGLFADVVQHAH        10        20        30        40        50        60        70        80        90       100       110       120 m261.pepFVRQRPRLRLGQIHQRRVDLKIIVHRQIKGNVHRFDKHVAAVGIAGEVGFAHARDDVPYP||||||||||||:|||||||||:|||||||||| ||:|:|||||| ::|||||||||| g261FVRQRPRLRLGQVHQRRVDLKIVVHRQIKGNVHGFDEHAAAVGIARKIGFAHARDDVPDT        70        80        90       100       110       120       130       140       150            160       170 m261.pepLPFGVNRGIEQEKRVAAVYKGIRNAVFGSFDGGGV-----VHQGIVRNLPHQAQVEYGLF|||| | |::|||||: |:||| ||| |:|||||      ||||:|||||||||:|||| g261LPFGKNGGVKQEKRVTPVHKGIGNAVVGGFDGGGFDGGGFVHQGVVRNLPHQAQIEYGLT       130       140       150       160       170       180  180       190       200       210       220       230 m261.pepDAQILRNPAGTFQLDGMALPVLESNGLDVFAPVGLDCLNQAGGRILTARKDDQGLLVX|:||||:|  :|||||||||| |::||||||||||||||||||||||||:||||:||| g261DTQILRDPLCAFQLDGMALPVSEGDGLDVFAPVGLDCLNQAGGRILTAREDDQGFLVX       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1051>:

a261.seq 1 ATGGAGCTTG GGCATATCGT ATTCCTTATG GTTTGCGCGT GTTCAGACGG 51CCTTTTTACT TTCCAGATAT TCCGCCAGCC CGCGTTCGCG CAAGATACAG 101 CTCGGGCATTCGCGGCAGCC GCCGACGATG CCGTTATAGC AGGTGTGGGT 151 TTGCTCGCGG ATATAGTCCAGCGCGCCCAT TTCGTCCGCC AACGCCCAAG 201 TTTGCGCCTT GGTCAGATAC ATCAGCGGCGTGTGGATTTG AAAATCATAG 251 TCCATCGCCA GATTAAGGGT AACGTTCATG GATTTGACAAACACGTCACG 301 GCAGTCGGGA TAGCCGGAGA AGTCGGTTTC GCACACGCCC GCGATGATGT351 GCCGTATCCC CTGCCCTTTG GCGTAAATCG CGGCATAGAG CAGGAAAAGC 401GCGTTGCGGC CGTCTACAAA GGTATTCGGA ACGCCGTTTT CGGCAGTTTC 451 GATGGCGGCGGTGTCGTCCA TCAGGGCATT GTGCGTAATC TGCCGCATCA 501 GGCTCAAGTC GAGTACGGTTTGTTTGACGC CCAAATCCTG CGCAATCCAG 551 CGGGCACGTT CCAGCTCGAC GGCATGGCGTTGCCCGTATT GGAAAGTAAT 601 GGCTTGGACG TTTTCGCGCC CGTAGGTTTG GATTGCCTGAATCAGGCAGG 651 TGGTCGAATC CTGACCGCCC GAAAAGATGA CCAAGGCTTT TTGGTTTGAThis corresponds to the amino acid sequence <SEQ ID 1052; ORF 261.a>:

a261.pep 1 MELGHIVFLM VCACSDGLFT FQIFRQPAFA QDTARAFAAA ADDAVIAGVG 51LLADIVQRAH FVRQRPSLRL GQIHQRRVDL KIIVHRQIKG NVHGFDKHVT 101 AVGIAGEVGFAHARDDVPYP LPFGVNRGIE QEKRVAAVYK GIRNAVFGSF 151 DGGGVVHQGI VRNLPHQAQVEYGLFDAQIL RNPAGTFQLD GMALPVLESN 201 GLDVFAPVGL DCLNQAGGRI LTARKDDQGFLV* m261/a261 97.8% identity in 232 aa overlap        10        20        30        40        50        60 m261.pepMELGHIVFLMVCACSDGLFTFQIFRQPAFAQDTARAFAAAADDAVIAGVGLLADIVQHAH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| a261MELGHIVFLMVCACSDGLFTFQIFRQPAFAQDTARAFAAAADDAVIAGVGLLADIVQRAH        10        20        30        40        50        60        70        80        90       100       110       120 m261.pepFVRQRPRLRLGQIHQRRVDLKIIVHRQIKGNVHRFDKHVAAVGIAGEVGFAHARDDVPYP|||||| |||||||||||||||||||||||||| |||||:|||||||||||||||||||| a261FVRQRPSLRLGQIHQRRVDLKIIVHRQIKGNVHGFDKHVTAVGIAGEVGFAHARDDVPYP        70        80        90       100       110       120       130       140       150       160       170       180 m261.pepLPFGVNRGIEQEKRVAAVYKGIRNAVFGSFDGGGVVHQGIVRNLPHQAQVEYGLFDAQIL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a261LPFGVNRGIEQEKRVAAVYKGIRNAVFGSFDGGGVVHQGIVRNLPHQAQVEYGLFDAQIL       130       140       150       160       170       180       190       200       210       220       230 m261.pepRNPAGTFQLDGMALPVLESNGLDVFAPVGLDCLNQAGGRILTARKDDQGLLVX|||||||||||||||||||||||||||||||||||||||||||||||||:||| a261RNPAGTFQLDGMALPVLESNGLDVFAPVGLDCLNQAGGRILTARKDDQGFLVX       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1053>:

g263.seq 1 atggcacgtt taaccgtaca caccctcgaa accgcccccg aagccgccaa 51accgcgcgta gaggccgtac ccaaaaacaa cggctttatc cccaacctca 101 tcggcgtattggcaaacgcc cccgaagctt tggcgtttta ccaagaagtc 151 ggcaagctca acgccgccaacagcctgacc gccggcgaag tcgaagtgat 201 ccggatcatc gccgtccgca ccaaccaatgcagcttctgc gtggcagggc 251 acaccaaact cgcaaccctg aaaaaactcc tgtccgagcaatccctcaat 301 gccgcccgcg ctttggcggc aggtaaatct gacgatgcca aactcggcgc351 gcttgccgcc ttcacccaag ccgtaatggc gaaaaaaggc gcagtatccg 401acgacgaact caacgccttc ctcgaagcgg gctacaaccg gcagcaggca 451 gtcgaagtcgtaatgggcgt agccttggca actttgtgca actacgccaa 501 caacctcgcc caaaccgaaatcaaccccaa attgcaggca tacgcctaaThis corresponds to the amino acid sequence <SEQ ID 1054; ORF 263.ng>:

g263.pep 1 MARLTVHTLE TAPEAAKPRV EAVPKNNGFI PNLIGVLANA PEALAFYQEV 51GKLNAANSLT AGEVEVIRII AVRTNQCSFC VAGHTKLATL KKLLSEQSLN 101 AARALAAGKSDDAKLGALAA FTQAVMAKKG AVSDDELNAF LEAGYNRQQA 151 VEVVMGVALA TLCNYANNLAQTEINPKLQA YA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1055>:

m263.seq (partial) 1 ..GCAGCAGGCG AATTTGACGA TGCCAAACTC GGCGCGCTCGCCGCCTTCAC 51   CCAAGCCGTA ATGGCGAAAA AAGGCGCGGT ATCCGACGAG GAACTCAAAG101   CATTTTTCGA TGCGGGCTAC AACCAGCAGC AGGCAGTCGA AGTCGTGATG 151  GGCGT.AsyC TgGCAACCCT GTGCAACTAC GTCAACAACC TCGGACAAAC 201  CGAAATCAAC CCCGAATTGC AGGCTTACGC CTGAThis corresponds to the amino acid sequence <SEQ ID 1056; ORF 263>:

m263.pep (partial) 1 ..GCAGCAGGCG AATTTGACGA TGCCAAACTC GGCGCGCTCGCCGCCTTCAC 51   CCAAGCCGTA ATGGCGAAAA AAGGCGCGGT ATCCGACGAG GAACTCAAAG101   CATTTTTCGA TGCGGGCTAC AACCAGCAGC AGGCAGTCGA AGTCGTGATG 151  GGCGT.AsyC TgGCAACCCT GTGCAACTAC GTCAACAACC TCGGACAAAC 201  CGAAATCAAC CCCGAATTGC AGGCTTACGC CTGAComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 263 shows 85.7% identity over a 77 aa overlap with a predicted ORF(ORF 263.ng) from N. gonorrhoeae:

m263/g263                                       10        20        30m263.pep                               AAGEFDDAKLGALAAFTQAVMAKKGAVSDE                              |||: ||||||||||||||||||||||||: g263QCSFCVAGHTKLATLKKLLSEQSLNAARALAAGKSDDAKLGALAAFTQAVMAKKGAVSDD  80        90        100       110       120       130        40        50        60        70 m263.pepELKAFFDAGYNQQQAVEVVMGVXLATLCNYVNNLGQTEINPELQAYAX||:||::||||:|||||||||| |||||||:|||:||||||:|||||| g263ELNAFLEAGYNRQQAVEVVMGVALATLCNYANNLAQTEINPKLQAYAX  140       150       160       170       180The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1057>:

a263.seq 1 ATGGCACGTT TAACCGTACA CACCCTCGAA ACCGCCCCCG AAGCCGCCAA 51AGCGCGCGTC GAGGCGGTAC TTCAAAACAA CGGCTTTATC CCCAACCTTA 101 TCGGCGTATTATCAAACGCC CCCGAAGCCT TGGCGTTTTA CCAAGAAGTC 151 GGCAAGCTCA ACGCCGCCAACAGCCTGACC GCCGGCGAAG TCGAAGTAAT 201 CCAGATTATT GCCGCCCGCA CCAACCAATGCGGCTTCTGC GTGGCAGGGC 251 ACACCAAACT CGCAACCCTG AAAAAACTCC TTTCCGAACAATCCGTCAAA 301 GCCGCGCGCG CTTTGGCGGC AGGCGAATTT GACGATGCTA AACTCGGCGC351 GCTCGCCGCC TTTACCCAAG CCGTAATGGC AAAAAAAGGC GCGGTATCCG 401ACGAGGAACT CAAAGCATTT TTTGATGCGG GCTACAACCA GCAGCAGGCA 451 GTCGAAGTCGTGATGGGCGT AGCCTTGGCA ACTTTGTGCA ACTACGTCAA 501 CAACCTCGGA CAAACCGAAATCAACCCCGA ATTGCAGGCT TACGCCTGAThis corresponds to the amino acid sequence <SEQ ID 1058; ORF 263.a>:

a263.pep 1 MARLTVHTLE TAPEAAKARV EAVLQNNGFI PNLIGVLSNA PEALAFYQEV 51GKLNAANSLT AGEVEVIQII AARTNQCGFC VAGHTKLATL KKLLSEQSVK 101 AARALAAGEFDDAKLGALAA FTQAVMAKKG AVSDEELKAF FDAGYNQQQA 151 VEVVMGVALA TLCNYVNNLGQTEINPELQA YA* m263/a263 97.4% identity in 77 aa overlap                                      10        20        30 m263.pep                              AAGEFDDAKLGALAAFTQAVMAKKGAVSDE                              |||||||||||||||||||||||||||||| a263QCGFCVAGHTKLATLKKLLSEQSVKAARALAAGEFDDAKLGALAAFTQAVMAKKGAVSDE  80        90        100       110       120       130        40        50        60        70 m263.pepELKAFFDAGYNQQQAVEVVMGXXLATLCNYVNNLGQTEINPELQAYAX|||||||||||||||||||||  ||||||||||||||||||||||||| a263ELKAFFDAGYNQQQAVEVVMGVALATLCNYVNNLGQTEINPELQAYAX  140       150       160       170       180The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1059>:

g264.seq 1 ttgactttaa cccgaaaaac ccttttcctc ctcaccgccg cgttcggcac 51acactccctt cagacggcat ccgccgacgc agtggtcaag ccggaaaaac 101 tgcacgcctccgccaaccgc agctacaaag tcgccgaatt cacgcaaacc 151 ggcaacgcct cgtggtacggcggcaggttt cacgggcgca aaacttccgg 201 cggagaccgc tacgatatga acgcctttaccgccgcccac aaaaccctgc 251 ccatccccag ccatgtgcgc gtaaccaaca ccaaaaacggcaaaagcgtc 301 atcgtccgcg tcaacgaccg cggccccttc cacggcaacc gcatcatcga351 cgtatccaaa gccgccgcgc aaaaattggg ctttgtcagc caagggacgg 401cacacgtcaa aatcgaacaa atcgtcccgg gccaatccgc accggttgcc 451 gaaaacaaagacatctttat cgacttgaaa tctttcggta cggaacacga 501 agcacaagcc tatctgaaccaagccgccca aaatttcgcc gcttcgtcat 551 caagcccgaa cctctcggtt gaaaaacgccgttacgaata cgttgtcaaa 601 atgggcccgt ttgcctcgca ggaacgcgcc gccgaagccgaagcgcaggc 651 acgcggtatg gttcgggcgg tactgacctc cggttgaThis corresponds to the amino acid sequence <SEQ ID 1060; ORF 264.ng>:

g264.pep 1 LTLTRKTLFL LTAAFGTHSL QTASADAVVK PEKLHASANR SYKVAEFTQT 51GNASWYGGRF HGRKTSGGDR YDMNAFTAAH KTLPIPSHVR VTNTKNGKSV 101 IVRVNDRGPFHGNRIIDVSK AAAQKLGFVS QGTAHVKIEQ IVPGQSAPVA 151 ENKDIFIDLK SFGTEHEAQAYLNQAAQNFA ASSSSPNLSV EKRRYEYVVK 201 MGPFASQERA AEAEAQARGM VRAVLTSG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1061>:

m264.seq 1 TTGACTTTAA CCCGAAAAAC CCTTTTCCTT CTCACCGCCG CATTCGGCAC 51ACACTCCCTT CAGACGGCAT CCGCCGACGC AGTGGTCAAG GCAGAAAAAC 101 TGCACGCCTCCGCCAACCGC AGCTACAAAG TCGCCGGAAA ACGCTACACG 151 CCGAAAAACC AAGTCGCCGAATTCACGCAA ACCGGCAACG CCTCGTGGTA 201 CGGCGGCAGG TTTCACGGGC GCAAAACTTCCGGCGGAGAA CGATACGATA 251 TGAACGCCTT TACCGCCGCC CACAAAACCC TGCCCATCCCCAGCTATGTG 301 CGCGTAACCA ATACCAAAAA CGGCAAAAGC GTCATCGTCC GCGTCAACGA351 CCGCGGCCCC TTCCACGGCA ACCGCATCAT CGACGTATCC AAAGCCGCCG 401CGCAAAAATT GGGCTTTGTC AACCAAGGGA CGGCACACGT CAAAATCGAA 451 CAAATCGTCCCGGGCCAATC CGCACCGGTT GCCGAAAACA AAGACATCTT 501 TATCGACTTG AAATCTTTCGGTACGGAACA CGAAGCACAA GCCTATCTGA 551 ACCAAGCCGC CCAAAACTTC GCCGTTTCGTCATCGGGTAC GAACCTCTCG 601 GTTGAAAAAC GCCGTTACGA ATACGTCGTC AAAATGGGACCGTTTACCTC 651 GCAGGAACGC GCCGCCGAAG CCGAAGCTCA GGCGCGCGGT ATGGTTCGGG701 CGGTATTGAC CGCCGGCTGAThis corresponds to the amino acid sequence <SEQ ID 1062; ORF 264>:

m264.pep 1 LTLTRKTLFL LTAAFGTHSL QTASADAVVK AEKLHASANR SYKVAGKRYT 51PKNQVAEFTQ TGNASWYGGR FHGRKTSGGE RYDMNAFTAA HKTLPIPSYV 101 RVTNTKNGKSVIVRVNDRGP FHGNRIIDVS KAAAQKLGFV NQGTAHVKIE 151 QIVPGQSAPV AENKDIFIDLKSFGTEHEAQ AYLNQAAQNF AVSSSGTNLS 201 VEKRRYEYVV KMGPFTSQER AAEAEAQARGMVRAVLTAG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 264 shows 91.6% identity over a 239 aa overlap with a predicted ORF(ORF 264.ng) from N. gonorrhoeae:

m264/g264           10        20        30        40        50        60m264.pep   LTLTRKTLFLLTAAFGTHSLQTASADAVVKAEKLHASANRSYKVAGKRYTPKNQVAEFTQ  |||||||||||||||||||||||||||||| ||||||||||||||           |||| g264  LTLTRKTLFLLTAAFGTHSLQTASADAVVKPEKLHASANRSYKVA-----------EFTQ          10        20        30        40          70        80        90       100       110       120 m264.pep  TGNASWYGGRFHGRKTSGGERYDMNAFTAAHKTLPIPSYVRVTNTKNGKSVIVRVNDRGP  |||||||||||||||||||:||||||||||||||||||:||||||||||||||||||||| g264  TGNASWYGGRFHGRKTSGGDRYDMNAFTAAHKTLPIPSHVRVTNTKNGKSVIVRVNDRGP 50        60        70        80        90       100         130       140       150       160       170       180 m264.pep  FHGNRIIDVSKAAAQKLGFVNQGTAHVKIEQIVPGQSAPVAENKDIFIDLKSFGTEHEAQ  ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||| g264  FHGNRIIDVSKAAAQKLGFVSQGTAHVKIEQIVPGQSAPVAENKDIFIDLKSFGTEHEAQ110       120       130       140       150       160         190       200       210       220       230       240 m264.pep  AYLNQAAQNFAVSSSGTNLSVEKRRYEYVVKMGPFTSQERAAEAEAQARGMVRAVLTAGX  |||||||||||:|||: ||||||||||||||||||:|||||||||||||||||||||:|| g264  AYLNQAAQNFAASSSSPNLSVEKRRYEYVVKMGPFASQERAAEAEAQARGMVRAVLTSGX170       180       190       200       210       220The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1063>:

a264.seq 1 TTGACTTTAA CCCGAAAAAC CCTTTTCCTC CTCACCGCCG CATTCGGCAT 51ACATTCCTTT CAGACGGCAT CCGCCGACGC AGTGGTCAGG GCAGAAAAAC 101 TGCACGCCTCCGCCAACCGC AGCTACAAAG TCGCCGGAAA ACGCTACACG 151 CCGAAAAACC AAGTCGCCGAATTCACGCAA ACCGGCAACG CCTCGTGGTA 201 CGGCGGCAGG TTTCACGGGC GCAAAACTTCCGGCGGAGAA CGATACGATA 251 TGAACGCCTT TACCGCCGCC CACAAAACCC TGCCCATCCCCAGCTATGTG 301 CGCGTAACCA ATACCAAAAA CGGCAAAAGC GTCATCGTCC GCGTCAACGA351 CCGCGGCCCC TTCCACGGCA ACCGCATCAT CGACGTATCC AAAGCCGCCG 401CGCAAAAATT GGGCTTTGTC AACCAAGGGA CGGCGCACGT CAAAATCGAA 451 CAAATCGTCCCGGGCCAATC CGCACCGGTT GCCGAAAACA AAGACATCTT 501 CATCGACTTG AAATCTTTCGGTACGGAACA CGAAGCACAA GCCTATCTGA 551 ACCAAGCCGC CCAAAACCTG GCTTCATCGGCATCAAACCC GAACCTCTCG 601 GTTGAAAAAC GCCGTTACGA ATACGTCGTC AAAATGGGACCGTTTGCCTC 651 GCAGGAACGC GCCGCCGAGG CCGAAGCTCA GGCGCGCGGT ATGGTTCGGG701 CGGTATTAAC CGCCGGTTGAThis corresponds to the amino acid sequence <SEQ ID 1064; ORF 264.a>:

a264.pep 1 LTLTRKTLFL LTAAFGIHSF QTASADAVVR AEKLHASANR SYKVAGKRYT 51PKNQVAEFTQ TGNASWYGGR FHGRKTSGGE RYDMNAFTAA HKTLPIPSYV 101 RVTNTKNGKSVIVRVNDRGP FHGNRIIDVS KAAAQKLGFV NQGTAHVKIE 151 QIVPGQSAPV AENKDIFIDLKSFGTEHEAQ AYLNQAAQNL ASSASNPNLS 201 VEKRRYEYVV KMGPFASQER AAEAEAQARGMVRAVLTAG* m264/a264 96.2% identity in 239 aa overlap        10        20        30        40        50        60 m264.pepLTLTRKTLFLLTAAFGTHSLQTASADAVVKAEKLHASANRSYKVAGKRYTPKNQVAEFTQ|||||||||||||||| ||:|||||||||:|||||||||||||||||||||||||||||| a264LTLTRKTLFLLTAAFGIHSFQTASADAVVRAEKLHASANRSYKVAGKRYTPKNQVAEFTQ        10        20        30        40        50        60        70        80        90       100       110       120 m264.pepTGNASWYGGRFHGRKTSGGERYDMNAFTAAHKTLPIPSYVRVTNTKNGKSVIVRVNDRGP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a264TGNASWYGGRFHGRKTSGGERYDMNAFTAAHKTLPIPSYVRVTNTKNGKSVIVRVNDRGP        70        80        90       100       110       120       130       140       150       160       170       180 m264.pepFHGNRIIDVSKAAAQKLGFVNQGTAHVKIEQIVPGQSAPVAENKDIFIDLKSFGTEHEAQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a264FHGNRIIDVSKAAAQKLGFVNQGTAHVKIEQIVPGQSAPVAENKDIFIDLKSFGTEHEAQ       130       140       150       160       170       180       190       200       210       220       230       240 m264.pepAYLNQAAQNFAVSSSGTNLSVEKRRYEYVVKMGPFTSQERAAEAEAQARGMVRAVLTAGX|||||||||:| |:|: ||||||||||||||||||:|||||||||||||||||||||||| a264AYLNQAAQNLASSASNPNLSVEKRRYEYVVKMGPFASQERAAEAEAQARGMVRAVLTAGX       190       200       210       220       230       240The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1065>:

m265.seq 1 ATGTCGGTGA TTTTGCCGCC GACACGCGCC AACGCTGCTT TTTCGGCTTG 51GGCGCGGCTG ATGATTTTGT CTTGTTTGTT GTGTTGGTGT GCGGCGTGTC 101 CGTGGTCGTCATCGCCGTGT CCGTCGTGGT GGGCGAGCGC GGGGGCGGAA 151 ATGCTCAGCA GTGCGGTTGCGGCGGAGGTC AAGAGAAGGT GTTTGATGTT 201 CATAT.TTTT GCCTTTGTAA ATCGTGGGTTGGAAAATGTG GATATTAATA 251 AGGTATCAAA TAACCGTCAG CCGGCGGTCA ATACCGCCCGAACCATACCG 301 CGCGCCTGAG CTTCGGCTTC GGCGGCGCGT TCCTGCGAGG TAAACGGTCC351 CATTTTGACG ACGTATTCGT AAThis corresponds to the amino acid sequence <SEQ ID 1066; ORF 265>:

m265.pep 1 MSVILPPTRA NAAFSAWARL MILSCLLCWC AACPWSSSPC PSWWASAGAE 51MLSSAVAAEV KRRCLMFIXF AFVNRGLENV DINKVSNNRQ PAVNTARTIP 101 RAXASASAARSCEVNGPILT TYS*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 265 shows 88.6% identity over a 123 aa overlap with a predicted ORF(ORF 265.ng) from N. gonorrhoeae:

m265/g265           10        20        30        40        50        60m265.pep   MSVILPPTRANAAFSAWARLMILSCLLCWCAACPWSSSPCPSWWASAGAEMLSSAVAAEV  ||||||||||:||||||||||||||| |||||||||||||||||||||||| :||||| | g265  MSVILPPTRAQAAFSAWARLMILSCLPCWCAACPWSSSPCPSWWASAGAEMPNSAVAAAV          10        20        30        40        50        60          70        80        90       100       110       120 m265.pep  KRRCLMFIXFAFVNRGLENVDINKVSNNRQPAVNTARTIPRAXASASAARSCEVNGPILT  |||||||| ||:||:||:| ||||||||||| |:|||||||| ||||||||||:|||||| g265  KRRCLMFI-FALVNQGLKNGDINKVSNNRQPEVSTARTIPRACASASAARSCEANGPILT           70        80        90       100       110 m265.pep   TYSX  |||| g265   TYSX 120The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1067>:

a265.seq 1 ATGTCGGTGA TTTTGCCGCC GACACGCGCC AACGCTGCTT TTTCGGCTTG 51GGCGCGGCTG ATGATTTTGT CTTGTTTGCT GTGTTGGTGT GCGGCGTGTC 101 CGTGGTCGTCATCGCCGTGT CCGTCGTGGT GGGCGAGTGC GGGGGCGGAA 151 ATGCCCATCA GTGCGGTTGCGGCGGCGGTC AAGAGAAGGC GTTTGAAGTT 201 CATTTTTGCT CCTGCGAAGT ATCTGGT........GGTGT TTGAAGGACG 251 TAAAGGCGGG ACATCAACCG GCGGTTAATA CCGCCCGAACCATACCGCGC 301 GCCTGAGCTT CGGCCTCGGC GGCGCGTTCC TGCGAGGCAA ACGGTCCCAT351 TTTGACGACG TATTCGTAAThis corresponds to the amino acid sequence <SEQ ID 1068; ORF 265.a>:

a265.pep 1 MSVILPPTRA NAAFSAWARL MILSCLLCWC AACPWSSSPC PSWWASAGAE 51MPISAVAAAV KRRRLKFIFA PAKYLX..XC LKDVKAGHQP AVNTARTIPR 101 A*ASASAARSCEANGPILTT YS* m265/a265 79.7% identity in 123 aa overlap        10        20        30        40        50        60 m265.pepMSVILPPTRANAAFSAWARLMILSCLLCWCAACPWSSSPCPSWWASAGAEMLSSAVAAEV|||||||||||||||||||||||||||||||||||||||||||||||||||  ||||| | a265MSVILPPTRANAAFSAWARLMILSCLLCWCAACPWSSSPCPSWWASAGAEMPISAVAAAV        10        20        30        40        50        60        70        80        90       100       110       120 m265.pepKRRCLMFIXFAFVNRGLENVDINKVSNNRQPAVNTARTIPRAXASASAARSCEVNGPILT||| | ||   |:        :: |: ::||||||||||||||||||||||||:|||||| a265KRRRLKFI---FAPAKYLXXCLKDVKAGHQPAVNTARTIPRAXASASAARSCEANGPILT           70        80        90       100       110 m265.pep TYSX ||||a265 TYSX 120The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1069>:

g266.seq 1 agttcagacg gcatcgccgc cgacaatgcc caaacagaaa gcccatcatg 51accgcatcca tgtacatcct tttggtcttg gcactcatct ttgccaacgc 101 ccccttcctcacgaccagac tgttcggcgt ggccgcgctc aagcgcaaac 151 atttcggaca ccacctgatcgagctggcgg caggtttcgc gctgaccgcc 201 tctcttgcct acatcctcga atcccgtgcgggagcggtac acaatcaggg 251 ttgggagttt tacgccaccg tcgtctgcct gtacctcattttcgccttcc 301 cgtgtttcgt gcggcggtat ttttggcaca cgcgcaacag ggaataaThis corresponds to the amino acid sequence <SEQ ID 1070; ORF 266.ng>:

g266.pep 1 MQFRRHRRRQ CPNRKPIMTA SMYILLVLAL IFANAPFLTT RLFGVAALKR 51KHFGHHLIEL AAGFALTASL AYILESRAGA VHNQGWEFYA TVVCLYLIFA 101 FPCFVRRYFWHTRNRE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1071>:

m266.seq 1 ATGCCGTTCC GCAACGCGtT cAGACGGCAT CGCCGCCGAC AACGCCTAAA 51CAGAAAGCCC ACCATGACCG CATCCATGTA CATCCTTTTG GTCTTGGCAC 101 TCATCTTTGCCAACGCCCCC TTCCTCACGA CCAGACTGTT CGGCGTGGCC 151 rCACTCAAGC GCAAACATTTCGGACACCAC ATGATCGAGC TGGCGGCAGG 201 TTTCGCGCTG ACCGCCGTTC TTGCCTACATCCTsGAATCC CGTGCAGGAT 251 CGGTACACGA TCAGGGTTGG GAGTTTTATG CCACAGTCGTCTGCCTGTAC 301 CTGATTTTTG CGTTTCCATG TTTTGTGTGG CGGTATTTTT GGCACACGCG351 CAACAGGGAA TAGThis corresponds to the amino acid sequence <SEQ ID 1072; ORF 266>:

m266.pep 1 MPFRNAFRRH RRRQRLNRKP TMTASMYILL VLALIFANAP FLTTRLFGVA 51XLKRKHFGHH MIELAAGFAL TAVLAYILES RAGSVHDQGW EFYATVVCLY 101 LIFAFPCFVWRYFWHTRNRE *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 266 shows 92.1% identity over a 114 aa overlap with a predicted ORF(ORF 266.ng) from N. gonorrhoeae:

m266/g266         10        20        30        40        50        60m266.pep MPFRNAFRRHRRRQRLNRKPTMTASMYILLVLALIFANAPFLTTRLFGVAXLKRKHFGHH      ||||||||  |||| ||||||||||||||||||||||||||||| ||||||||| g266    MQFRRHRRRQCPNRKPIMTASMYILLVLALIFANAPFLTTRLFGVAALKRKHFGHH            10        20        30        40        50        70        80        90       100       110       120 m266.pepMIELAAGFALTAVLAYILESRAGSVHDQGWEFYATVVCLYLIFAFPCFVWRYFWHTRNREX:||||||||||| ||||||||||:||:|||||||||||||||||||||| ||||||||||| g266LIELAAGFALTASLAYILESRAGAVHNQGWEFYATVVCLYLIFAFPCFVRRYFWHTRNREX  60        70        80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1073>:

a266.seq 1 ATGCCGTTCC GCAATGCGTT CAGACGGCAT CGCCGCCGAC AATGCCCAAA 51CAGAAAGCCC GCCATGACCG CATCCATGTA CATCCTTTTG CTGCTTGCCT 101 TGATTTTTGCCAACGCCCCC TTCCTCACGA CCAAGCTGTT CGGCATCGTA 151 CCGCTCAAGC GCAAACATTTCGGACACCAC CTGATCGAGC TGGCGGCAGG 201 TTTCGCGCTG ACCGCCGTTC TTGCCTACATCCTCGAATCC CGTGCGGGAG 251 CGGTACACGA TCAGGGTTGG GAGTTTTACG CCACCGTCGTCTGCCTGTAC 301 CTGATTTTTG CGTTTCCCTG TTTCGTGTGG CGGTATTTTT GGCACACGCG351 CAACAGGGAA TAGThis corresponds to the amino acid sequence <SEQ ID 1074; ORF 266.a>:

a266.pep 1 MPFRNAFRRH RRRQCPNRKP AMTASMYILL LLALIFANAP FLTTKLFGIV 51PLKRKHFGHH LIELAAGFAL TAVLAYILES RAGAVHDQGW EFYATVVCLY 101LIFAFPCFVW RYFWHTRNRE * m266/a266 91.7% identity in 120 aa overlap        10        20        30        40        50        60 m266.pepMPFRNAFRRHRRRQRLNRKPTMTASMYILLVLALIFANAPFLTTRLFGVAXLKRKHFGHH||||||||||||||  ||||:|||||||||:|||||||||||||:|||:: ||||||||| a266MPFRNAFRRHRRRQCPNRKPAMTASMYILLLLALIFANAPFLTTKLFGIVPLKRKHFGHH        10        20        30        40        50        60        70        80        90       100       110       120 m266.pepMIELAAGFALTAVLAYILESRAGSVHDQGWEFYATVVCLYLIFAFPCFVWRYFWHTRNRE:||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| a266LIELAAGFALTAVLAYILESRAGAVHDQGWEFYATVVCLYLIFAFPCFVWRYFWHTRNRE        70        80        90       100       110       120 m266.pep X| a266 XThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1075>:

g267.seq 1 atgcaagtcg ccttttttct cgccgtggta ttcaaaaata tgggtttcca 51caatcgcatc ggtcgggcag gcctcttcgc agaaaccgca gaagatgcac 101 ttggtcaggtcgatgtcgta acgcttggtg cggcgggtgc cgtcttcgcg 151 ttcttccgat tcgatgttgatcgccattgc cggacacacc gcctcgcaca 201 atttacacgc gatgcagcgt tcctctccgttcggaaaacg gcgttgcgcg 251 tgcagaccgc ggaaacgcac ggattgcggc gttttctcttcgggaaaata 301 aattgtgtct ttgcgggcaa aaaagttttt gagcgttacg cccatgcctt351 tgaccagttc gccaagcaga aaggttttta ctaaThis corresponds to the amino acid sequence <SEQ ID 1076; ORF 267.ng>:

g267.pep 1 MQVAFFLAVV FKNMGFHNRI GRAGLFAETA EDALGQVDVV TLGAAGAVFA 51FFRFDVDRHC RTHRLAQFTR DAAFLSVRKT ALRVQTAETH GLRRFLFGKI 101 NCVFAGKKVFERYAHAFDQF AKQKGFY*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1077>:

m267.seq 1 GTGCAAGTCG CCTTTTTTCT CGCCGTGGTA TTCAAAAATA TGGGTTTCCA 51CAATCGCATC AGTCGGGCAT GCCTCTTCGC AGAAACCGCA GAAGATGCAC 101 TTGGTCAGGTCGATGTCGTA ACGCTTGGTG CGGCGCGTAC CGTCTTCACG 151 TTCTTCCGAT TCGATGTTAATCGCCATTGC CGGACACACT GCCTCACACA 201 ACTTACACGC GATACACCGC TCTTCGCCGTTCGGATACCG CcGCTGCGCG 251 TGCAGACCGC GGAAACGCAC GGATTGCGGC GTTTTCTCTTCGGGGAAATA 301 AATTGTGTCT TTGCGGGCGA AAAAGTTTTT GAGCGTTACG CCCATACCTT351 TTACCAATTC GCCAAGCAGA AAGGTTTTTA CTAAThis corresponds to the amino acid sequence <SEQ ID 1078; ORF 267>:

m267.pep 1 VQVAFFLAVV FKNMGFHNRI SRACLFAETA EDALGQVDVV TLGAARTVFT 51FFRFDVNRHC RTHCLTQLTR DTPLFAVRIP PLRVQTAETH GLRRFLFGEI 101 NCVFAGEKVFERYAHTFYQF AKQKGFY*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 267 shows 82.7% identity over a 127 aa overlap with a predicted ORF(ORF 267.ng) from N. gonorrhoeae:

m267/g267         10        20        30        40        50        60m267.pep VQVAFFLAVVFKNMGFHNRISRACLFAETAEDALGQVDVVTLGAARTVFTFFRFDVNRHC:|||||||||||||||||||:| ||||||||||||||||||||| :||:||||||:||| g267MQVAFFLAVVFKNMGFHNRIGRAGLFAETAEDALGQVDVVTLGAAGAVFAFFRFDVDRHC        10        20        30        40        50        60        70        80        90       100       110       120 m267.pepRTHCLTQLTRDTPLFAVRIPPLRVQTAETHGLRRFLFGEINCVFAGEKVFERYAHTFYQF||| |:|:|||: :::||   |||||||||||||||||:|||||||:||||||||:| || g267RTHRLAQFTRDAAFLSVRKTALRVQTAETHGLRRFLFGKINCVFAGKKVFERYAHAFDQF        70        80        90       100       110       120 m267.pepAKQKGFYX |||||||| g267 AKQKGFYXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1079>:

a267.seq 1 GTGCAAGTCG CCTTTTTTCT CGCCGTGGTA TTCAAAAATA TGGGTTTCCA 51CAATCGCATC GGTCGGGCAG GCTTCTTCGC AGAAACCGCA GAAGATGCAC 101 TTGGTCAGGTCGATGTCGTA ACGCTTGGTG CGGCGCGTGC CGTCTTCGCG 151 TTCTTCCGAT TCGATGTTGATCGCCATTGC GGGGCAAACG GCTTCACACA 201 ATTTACACGC GATGCAGCGT TCCTCGCCGTTTGGATAACG GCGTTGCGCG 251 TGCAGACCGC GGAAACGCAC GGATTGCGGC GTTTTCTCTTCGGGAAAATA 301 AATCGTGTCT TTGCGGGCAA AAAAGTTTTT GAGCGTTACG CCCATACCTT351 TTACCAATTC GCCAAGCAGA AAGGTTTTTA CTAAThis corresponds to the amino acid sequence <SEQ ID 1080; ORF 267.a>:

a267.pep 1 VQVAFFLAVV FKNMGFHNRI GRAGFFAETA EDALGQVDVV TLGAARAVFA 51FFRFDVDRHC GANGFTQFTR DAAFLAVWIT ALRVQTAETH GLRRFLFGKI 101 NRVFAGKKVFERYAHTFYQF AKQKGFY* m267/a267 82.7% identity in 127 aa overlap        10        20        30        40        50        60 m267.pepVQVAFFLAVVFKNMGFHNRISRACLFAETAEDALGQVDVVTLGAARTVFTFFRFDVNRHC||||||||||||||||||||:|| :|||||||||||||||||||||:||:||||||:||| a267VQVAFFLAVVFKNMGFHNRIGRAGFFAETAEDALGQVDVVTLGAARAVFAFFRFDVDRHC        10        20        30        40        50        60        70        80        90       100       110       120 m267.pepRTHCLTQLTRDTPLFAVRIPPLRVQTAETHGLRRFLFGEINCVFAGEKVFERYAHTFYQF  :::||:|||: ::|| |  |||||||||||||||||:|| ||||:||||||||||||| a267GANGFTQFTRDAAFLAVWITALRVQTAETHGLRRFLFGKINRVFAGKKVFERYAHTFYQF        70        80        90       100       110       120 m267.pepAKQKGFYX |||||||| a267 AKQKGFYXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1081>:

G268.seq 1 atgaaaaaaa atttacccgc actggcattg gcaagtatgc tgattttgtc 51gggctgcgac cgtttgggaa taggcaaccc gttttccgga aaggaaattt 101 cctgcggaagcgaagagact aaagagattt tggtcaaact ggtccgcgac 151 aatgtcgaag gtgaaaccgtcaaaactttt gacgacgacg cattcaaaga 201 ccaagcattt gccgatatcg gcatatcgcatatccgcaga atggtcgaac 251 gtttgggcat aaccgtcgat gaagtccgaa ctaccgagaaaaccgacacg 301 tccagcaaac tcaaatgtga agccgcgtta aaactggacg tgcccgacga351 tgttgtcgat tatgccgtcg ccgccaacca atctataggc aacagccata 401agaaaacgcc cgactttttt gaaccctact accgcaaaga aggcgcgtat 451 tatgtcaaaactatttctta cagcgtccag ccgacagacg acaaaagcaa 501 aatctttgcc gaactcagtcaggcacacga tatcatccat ccgctcagcg 551 agctggtgtc tatggcactg attaaagagccgttggacaa agcgaaacaa 601 aggaacgaaa aacttgaagc ggcagaagcc accgcgcaggaagcgaggga 651 ggcagaagaa gcggcggcgc aggaggcatt gggtcgggag caggaagccg701 cccgcgtatc cgaatgggaa gaacgctaca agctgtcgcg cagcgagttc 751gagcagtttt ggaaaggatt gcctcaaact gtacagaata agctgcaagc 801 ctcgcagaaaacatggaaaa gcggtatgga caagatctgt gccaacaatg 851 cgaaagccga aggtgaaacgccaaacggca taaaagtcag tgagttggcg 901 tgtaaaacgg cagaaaccga agcacgcttggaagagctgc acaaccgtaa 951 aaaagccctt atcgacgaaa tggtcaggga agaggacaagaaagaactgc 1001 caaagcggct ctgaThis corresponds to the amino acid sequence <SEQ ID 1082; ORF 268.ng>:

m268.pep 1 MKKNLPALAL ASMLILSGCD RLGIGNPFSG KEISCGSEET KEILVKLVRD 51NVEGETVKTF DDDAFKDQAF ADIGISHIRR MVERLGITVD EVRTTEKTDT 101 SSKLKCEAALKLDVPDDVVD YAVAANQSIG NSHKKTPDFF EPYYRKEGAY 151 YVKTISYSVQ PTDDKSKIFAELSQAHDIIH PLSELVSMAL IKEPLDKAKQ 201 RNEKLEAAEA TAQEAREAEE AAAQEALGREQEAARVSEWE ERYKLSRSEF 251 EQFWKGLPQT VQNKLQASQK TWKSGMDKIC ANNAKAEGETPNGIKVSELA 301 CKTAETEARL EELHNRKKAL IDEMVREEDK KELPKRL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1083>:

m268.seq (partial) 1 ..ATGGCACTGA TTAAAGAGCC GTTGGACAAA GTGAAACAAAGGAACGAAGA 51   ACTTGAAGCG GCAGAAGAAG CGGCGGCGCA GGAGGCATTG GGTCGGGAGC101   AGGAAGCCGC CCGCGTATCC GAATGGGAAG AACGCTACAA GCTGTCGCGC 151  AG.CAGTTCG AGCAGTTCTG GAAAGGATTG CCTCAAACCG TACAGAATAA 201  GCTGCAACCn TCACAGAAAA CATGGAAAAG CGGGATGGAT AAAATCTGTG 251  CCAACAATGC GAAAGCTGAA GGTAAAACGC CAAACGGCAT AAAATTCAGC 301  GAACTGGCAT GCAAAACGGC GAAAACCGAA GCACGCTTGG AAGAGCTGCA 351  CAACCGTAAA AAAGCCCTTA TCGACGAAAT GGyCAGGGAA GCGGACAmGA 401  AAGAACTGTC AAAGCGGCTs TGAThis corresponds to the amino acid sequence <SEQ ID 1084; ORF 268>:

m268.pep (partial) 1 ..MALIKEPLDK VKQRNEELEA AEEAAAQEAL GREQEAARVSEWEERYKLSR 51   XQFEQFWKGL PQTVQNKLQP SQKTWKSGMD KICANNAKAE GKTPNGIKFS101   ELACKTAKTE ARLEELHNRK KALIDEMXRE ADXKELSKRL *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 268 shows 86.0% identity over a 150 aa overlap with a predicted ORF(ORF 268.ng) from N. gonorrhoeae:

m268/g268                                       10        20 m268.pep                              MALIKEPLDKVKQRNEELEAAE--------                              ||||||||||:|||||:||||| g268SVQPTDDKSKIFAELSQAHDIIHPLSELVSMALIKEPLDKAKQRNEKLEAAEATAQEARE160       170       180       190       200       210        30        40        50        60        70        80 m268.pep--EAAAQEALGREQEAARVSEWEERYKLSRSQFEQFWKGLPQTVQNKLQPSQKTWKSGMD  |||||||||||||||||||||||||||||:||||||||||||||||| |||||||||| g268AEEAAAQEALGREQEAARVSEWEERYKLSRSEFEQFWKGLPQTVQNKLQASQKTWKSGMD220       230       240       250       260       270        90       100       110       120       130       140 m268.pepKICANNAKAEGKTPNGIKFSELACKTAKTEARLEELHNRKKALIDEMXREADXKELSKRLX|||||||||||:|||||| ||||||||:||||||||||||||||||| || | ||| |||| g268KICANNAKAEGETPNGIKVSELACKTAETEARLEELHNRKKALIDEMVREEDKKELPKRLX280       290       300       310       320       330The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1085>:

a268.seq 1 ATGGCACTGA TTAAAGAGCC GTTGGACAAA GCGAAACAAA GGAACGAAGA 51ACTTGAAGCG GCAGAAGAAG CGGCGGCGCA GGAGGCATTG GGTCGGGAGC 101 AGGAAGTCGACCGCGTATCC GAATGGGAAG AACGCTACAA GCTGTCGCGC 151 AGCGAGTTCG AGCAGTTCTGGAAAGGATTG CCTCAAACCG TACAGAATAA 201 GCTGCAAGCC TCACAGAAAA CATGGAAAAGCGGGATGGAT AAAATCTGTG 251 CCAACAATGC GAAAGCTGAA GGTGAAACGC CAAACGGCATAAAATTCAGC 301 GAACTGGCAT GCAAAACGGC GGAAACCGAA GCACGCTTGG AAGAGCTGCA351 CAACCGTAAA AAAGCCCTTC TCGACGAAAT GGCCAGGGAA GCGGACAAGA 401AAGAACTGCC AAAGCGGCTC TGAThis corresponds to the amino acid sequence <SEQ ID 1086; ORF 268.a>:

a268.pep 1 MALIKEPLDK AKQRNEELEA AEEAAAQEAL GREQEVDRVS EWEERYKLSR 51SEFEQFWKGL PQTVQNKLQA SQKTWKSGMD KICANNAKAE GETPNGIKFS 101 ELACKTAETEARLEELHNRK KALLDEMARE ADKKELPKRL * m268/a268 91.4% identity in 140 aaoverlap         10        20        30        40        50        60m268.pep MALIKEPLDKVKQRNEELEAAEEAAAQEALGREQEAARVSEWEERYKLSRXQFEQFWKGL||||||||||:||||||||||||||||||||||||: ||||||||||||| :|||||||| a268MALIKEPLDKAKQRNEELEAAEEAAAQEALGREQEVDRVSEWEERYKLSRSEFEQFWKGL        10        20        30        40        50        60        70        80        90       100       110       120 m268.pepPQTVQNKLQPSQKTWKSGMDKICANNAKAEGKTPNGIKFSELACKTAKTEARLEELHNRK||||||||| |||||||||||||||||||||:|||||||||||||||:|||||||||||| a268PQTVQNKLQASQKTWKSGMDKICANNAKAEGETPNGIKFSELACKTAETEARLEELHNRK        70        80        90       100       110       120       130       140 m268.pep KALIDEMXREADXKELSKRLX|||:||| |||| ||| |||| a268 KALLDEMAREADKKELPKRLX        130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1087>:

m268-1.seq 1 GTGCAATCCC GATATGATGG TTTGCATAAA TTTAAACATA TATGTTCCGC 51AGCTATGGCA CTGATTAAAG AGCCGTTGGA CAAAGTGAAA CAAAGGAACG 101 AAGAACTTGAAGCGGCAGAA GAAGCGGCGG CGCAGGAGGC ATTGGGTCGG 151 GAGCAGGAAG CCGCCCGCGTATCCGAATGG GAAGAACGCT ACAAGCTGTC 201 GCGCAGCGAG TTCGAGCAGT TCTGGAAAGGATTGCCTCAA ACCGTACAGA 251 ATAAGCTGCA AGCCTCACAG AAAACATGGA AAAGCGGGATGGATAAAATC 301 TGTGCCAACA ATGCGAAAGC TGAAGGTAAA ACGCCAAACG GCATAAAATT351 CAGCGAACTG GCATGCAAAA CGGCGAAAAC CGAAGCACGC TTGGAAGAGC 401TGCACAACCG TAAAAAAGCC CTTATCGACG AAATGGCCAG GGAAGCGGAC 451 AAGAAAGAACTGTCAAAGCG GCTCTGAThis corresponds to the amino acid sequence <SEQ ID 1088; ORF 268-1>:

m268-1.pep 1 VQSRYDGLHK FKHICSAAMA LIKEPLDKVK QRNEELEAAE EAAAQEALGR 51EQEAARVSEW EERYKLSRSE FEQFWKGLPQ TVQNKLQASQ KTWKSGMDKI 101 CANNAKAEGKTPNGIKFSEL ACKTAKTEAR LEELHNRKKA LIDEMAREAD 151 KKELSKRL* m268-1/g26882.3% identity in 164 aa overlap                                  10        20        30 m268-1.pep                          VQSRYDGLHKFKHICSAAMALIKEPLDKVKQRNE                              :| :| :::: |  ||||||||||:||||| g268KEGAYYVKTISYSVQPTDDKSKIFAELSQAHDIIHPLSELVS--MALIKEPLDKAKQRNE  150       160       170       180         190       200    40                  50        60        70        80 m268-1.pepELEAAE----------EAAAQEALGREQEAARVSEWEERYKLSRSEFEQFWKGLPQTVQN:|||||          |||||||||||||||||||||||||||||||||||||||||||| g268KLEAAEATAQEAREAEEAAAQEALGREQEAARVSEWEERYKLSRSEFEQFWKGLPQTVQN    210       220       230       240       250       260    90       100       110       120       130       140 m268-1.pepKLQASQKTWKSGMDKICANNAKAEGKTPNGIKFSELACKTAKTEARLEELHNRKKALIDE|||||||||||||||||||||||||:|||||| ||||||||:|||||||||||||||||| g268KLQASQKTWKSGMDKICANNAKAEGETPNGIKVSELACKTAETEARLEELHNRKKALIDE    270       280       290       300       310       320   150      159 m268-1.pep MAREADKKELSKRLX |:|| ||||| |||| g268MVREEDKKELPKRLX     330The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1089>:

a268-1.seq 1 GTGCAATCCC GATATGATGG TTTGCATAAA TTTAAACATA TATGTTCCGC 51AGCTATGGCA CTGATTAAAG AGCCGTTGGA CAAAGCGAAA CAAAGGAACG 101 AAGAACTTGAAGCGGCAGAA GAAGCGGCGG CGCAGGAGGC ATTGGGTCGG 151 GAGCAGGAAG TCGACCGCGTATCCGAATGG GAAGAACGCT ACAAGCTGTC 201 GCGCAGCGAG TTCGAGCAGT TCTGGAAAGGATTGCCTCAA ACCGTACAGA 251 ATAAGCTGCA AGCCTCACAG AAAACATGGA AAAGCGGGATGGATAAAATC 301 TGTGCCAACA ATGCGAAAGC TGAAGGTGAA ACGCCAAACG GCATAAAATT351 CAGCGAACTG GCATGCAAAA CGGCGGAAAC CGAAGCACGC TTGGAAGAGC 401TGCACAACCG TAAAAAAGCC CTTCTCGACG AAATGGCCAG GGAAGCGGAC 451 AAGAAAGAACTGCCAAAGCG GCTCTGAThis corresponds to the amino acid sequence <SEQ ID 1090; ORF 268-1.a>:

a268-1.pep 1 VQSRYDGLHK FKHICSAAMA LIKEPLDKAK QRNEELEAAE EAAAQEALGR 51EQEVDRVSEW EERYKLSRSE FEQFWKGLPQ TVQNKLQASQ KTWKSGMDKI 101 CANNAKAEGETPNGIKFSEL ACKTAETEAR LEELHNRKKA LLDEMAREAD 151 KKELPKRL* a268-1/m268-195.6% identity in 158 aa overlap        10        20        30        40        50        60 a268-1.pepVQSRYDGLHKFKHICSAAMALIKEPLDKAKQRNEELEAAEEAAAQEALGREQEVDRVSEW||||||||||||||||||||||||||||:||||||||||||||||||||||||: ||||| m268-1VQSRYDGLHKFKHICSAAMALIKEPLDKVKQRNEELEAAEEAAAQEALGREQEAARVSEW        10        20        30        40        50        60        70        80        90       100       110       120 a268-1.pepEERYKLSRSEFEQFWKGLPQTVQNKLQASQKTWKSGMDKICANNAKAEGETPNGIKFSEL|||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||| m268-1EERYKLSRSEFEQFWKGLPQTVQNKLQASQKTWKSGMDKICANNAKAEGKTPNGIKFSEL        70        80        90       100       110       120       130       140       150      159 a268-1.pepACKTAETEARLEELHNRKKALLDEMAREADKKELPKRLX|||||:|||||||||||||||:|||||||||||| |||| m268-1ACKTAKTEARLEELHNRKKALIDEMAREADKKELSKRLX        130       140       150The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1091>:

g269.seq 1 atggtttggc gtgtgaattg cgcggcaacg gcggcgctga ttttttcgtc 51cagcccttgg atttgggcgg tggtgtgggt gtggtcgcgg tcggcttttt 101 cctgcaaaccttgcgccagc cttgacgcgt ccagtgcgcc ggcgttggcg 151 gtttcgccgt gggactttatccggaacacg gcttcgccca aggtgtcggc 201 ggctttgatg cacagtttta aaaccagggctttggggcgg ttttctgcgc 251 cgcccgttgc cattttgctg tccaatcgcg gggttaaaaaaccgttgtcg 301 tttaagtcgc cgtccgtcca agtcgatacg agcgcgcttc tttgcctttc351 attgcggtct tcgtaaThis corresponds to the amino acid sequence <SEQ ID 1092; ORF 269.ng>:

g269.pep 1 MVWRVNCAAT AALIFSSSPW IWAVVWVWSR SAFSCKPCAS LDASSAPALA 51VSPWDFIRNT ASPKVSAALM HSFKTRALGR FSAPPVAILL SNRGVKKPLS 101 FKSPSVQVDTSALLCLSLRS S*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1093>:

m269.seq 1 ATGGTTTGGC GTGTGAATTG CGCGGCAACG GCGGTGCTGA TTTTTTCGTC 51CAGCCCTTGG ATTTGGGCGG CGGTGTGGGT GTGGTCTCGG TCGGCTTTGT 101 CTTGCAAACCTTGCGCCaCG TGCCCGCGTC CAGCGCCTGC GTTGATGGTT 151 TCGCCGTGGG ACTTTATCCAAAACACGGCT TCGCCCAAGG TGTCGGCGGC 201 TTTGATGCAC AGTTTTAAAA CCAGGGCTTTGGGGCGGTTT TCGTCGCCGC 251 CTGTCGCCAT TTTGCTGTCC GAGCGCGGGG TTAAAAAGCCGTTGTCGTTT 301 AAATTTTCGT CCGTCCAAGT CGATACGAGC GCGCTTCTCT GCCTTTCGTT351 GCGGTCTTCG TAAThis corresponds to the amino acid sequence <SEQ ID 1094; ORF 269>:

m269.pep 1 MVWRVNCAAT AVLIFSSSPW IWAAVWVWSR SALSCKPCAT CPRPAPALMV 51SPWDFIQNTA SPKVSAALMH SFKTRALGRF SSPPVAILLS ERGVKKPLSF 101 KFSSVQVDTSALLCLSLRSS *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 269 shows 87.6% identity over a 121 aa overlap with a predicted ORF(ORF 269.ng) from N. gonorrhoeae:

m269.pep MVWRVNCAATAVLIFSSSPWIWAAVWVWSRSALSCKPCATCP-RPAPALMVSPWDFIQNT 59|||||||||||:|||||||||||:||||||||:||||||:     |||| |||||||:|| g269MVWRVNCAATAALIFSSSPWIWAVVWVWSRSAFSCKPCASLDASSAPALAVSPWDFIRNT 60 m269.pepASPKVSAALMHSFKTRALGRFSSPPVAILLSERGVKKPLSFKFSSVQVDTSALLCLSLRS 119||||||||||||||||||||||:||||||||:||||||||||  |||||||||||||||| g269ASPKVSAALMHSFKTRALGRFSAPPVAILLSNRGVKKPLSFKSPSVQVDTSALLCLSLRS 120m269.pep SX 121 || g269 SX 122The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1095>:

a269.seq 1 ATGGTTTGGC GTGTGAATTG CGCGGCAACG GCGGTGCTGA TTTTTTCGTC 51CAGCCCTTGG ATTTGGGCGG CGGTGTGGGT GTGGGCGCGG TCTGCTTTGT 101 CTTGGAGGTTTTGCGCCAGC GTGCCCGCGT CCAGCGCGCC GGCGTTGACG 151 GTTTCGCCGT GGGACTTTATCCAGAACACG GCTTCGCCCA AGGTGTCGGC 201 GGCTTTGATG CACAGTTTTA AAACCAGGGCTTTGGGGCGG TTTTCGTCGC 251 CGCCTGTCGC CATTTTGCTG TCCGGGCGCG GGGTTAAAAAGCCGTTGTCG 301 TTTAAATTTT CGTCCGTCCA AGTCGATACG AGCGCGCTTC TCTGCCTTTC351 GTTGTGGTCT TCGTAAThis corresponds to the amino acid sequence <SEQ ID 1096; ORF 269.a>:

a269.pep 1 MVWRVNCAAT AVLIFSSSPW IWAAVWVWAR SALSWRFCAS VPASSAPALT 51VSPWDFIQNT ASPKVSAALM HSFKTRALGR FSSPPVAILL SGRGVKKPLS 101 FKFSSVQVDTSALLCLSLWS S* m269/a269 90.1% identity in 121 aa overlap          10        20        30        40        50        60 m269.pep  MVWRVNCAATAVLIFSSSPWIWAAVWVWSRSALSCKPCATCP-RPAPALMVSPWDFIQNT  ||||||||||||||||||||||||||||:||||| : ||: |   |||| |||||||||| a269  MVWRVNCAATAVLIFSSSPWIWAAVWVWARSALSWRFCASVPASSAPALTVSPWDFIQNT          10        20        30        40        50        60 60        70        80        90       100       110      119 m269.pep  ASPKVSAALMHSFKTRALGRFSSPPVAILLSERGVKKPLSFKFSSVQVDTSALLCLSLRS  ||||||||||||||||||||||||||||||| |||||||||||||||||||||||||| | a269  ASPKVSAALMHSFKTRALGRFSSPPVAILLSGRGVKKPLSFKFSSVQVDTSALLCLSLWS          70        80        90       100       110       120 120m269.pep   SX   || a269   SXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1097>:

g270.seq 1 atgaataaaa accgcaaatt actgcttgcc gcactgctgc tgactgcctt 51tgccgccttc aagctcgttt tgttgcaatg gtggcaggcg cagcagccgc 101 aagccgtggcggcgcaatgc gatttgaccg agggttgcac gctgccggac 151 ggaagccgtg tccgcgccgccgccgtttca accaaaaaac cgtttgatat 201 ttatatcgaa cacgcgcccg ccggcacggaacaggtcagc atcagcttca 251 gtatgaaaaa tatggatatg ggtttcaacc gctatatgttcgagcggcaa 301 ccgtcgggga cttggcaggc agcacgcatc cgcctgcccg tctgtgtcga351 aggcaggcgc gattttacgg cggacattac aatcggcagc cggacatttc 401agacggcatt taccgccgaa taaThis corresponds to the amino acid sequence <SEQ ID 1098; ORF 270.ng>:

g270.pep 1 MNKNRKLLLA ALLLTAFAAF KLVLLQWWQA QQPQAVAAQC DLTEGCTLPD 51GSRVRAAAVS TKKPFDIYIE HAPAGTEQVS ISFSMKNMDM GFNRYMFERQ 101 PSGTWQAARIRLPVCVEGRR DFTADITIGS RTFQTAFTAE *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1099>:

m270.seq 1 ATGAATAAAA ACCGTAAATT ACTGCTTGCC GCACTGCTGC TGATTGCCTT 51TGCCGCCGTC AAGCTCGTTT TGTTGCAATG GTGGCAGGCG Ca.CAGCCGC 101 AAGCTGTGGCGGCGCAATGC GATTTGACCG AGGGTTGCAC GCTGCCGGAC 151 GGAAGCCGCG TCCGCGCCGCCGCcGTTTCA ACCAAAAAAC CGTTTGATAT 201 TTATATCGAA CACGCGCCCG CCGGCACGGAACAGGTCAGC ATCAGCTTCA 251 GTATGAAAAA TATGGATATG GGTTTCaACC GCTATATGTTCGAGCGGCAA 301 cCGTCGGGGA CTTGGCAGGC AGTACGCATC CGCCTGCCCA TCTGTGTCGA351 AGGCAGGCGC GATTTTACGG CGGACATTAC AATCGGCAGT CGGACATTTC 401AGACGGCATT TACCGCCGAA TAAThis corresponds to the amino acid sequence <SEQ ID 1100; ORF 270>:

m270.pep 1 MNKNRKLLLA ALLLIAFAAV KLVLLQWWQA XQPQAVAAQC DLTEGCTLPD 51GSRVRAAAVS TKKPFDIYIE HAPAGTEQVS ISFSMKNMDM GFNRYMFERQ 101 PSGTWQAVRIRLPICVEGRR DFTADITIGS RTFQTAFTAE *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 270 shows 96.4% identity over a 140 aa overlap with a predicted ORF(ORF 270.ng) from N. gonorrhoeae:

m270/g270         10        20        30        40        50        60m270.pep MNKNRKLLLAALLLIAFAAVKLVLLQWWQAXQPQAVAAQCDLTEGCTLPDGSRVRAAAVS|||||||||||||| |||| |||||||||| ||||||||||||||||||||||||||||| g270MNKNRKLLLAALLLTAFAAFKLVLLQWWQAQQPQAVAAQCDLTEGCTLPDGSRVRAAAVS        10        20        30        40        50        60        70        80        90       100       110       120 m270.pepTKKPFDIYIEHAPAGTEQVSISFSMKNMDMGFNRYMFERQPSGTWQAVRIRLPICVEGRR|||||||||||||||||||||||||||||||||||||||||||||||:|||||:|||||| g270TKKPFDIYIEHAPAGTEQVSISFSMKNMDMGFNRYMFERQPSGTWQAARIRLPVCVEGRR        70        80        90       100       110       120       130       140 m270.pep DFTADITIGSRTFQTAFTAEX||||||||||||||||||||| g270 DFTADITIGSRTFQTAFTAEX        130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1101>:

a270.seq 1 ATGAATAAAA ACCGTAAATT ACTGCTTGCC GCACTGCTGC TGATTGCCTT 51TGCCGCCGTC AAGCTCGTTT TGTTGCAATG GTGGCAGGCG CAGCAGCCGC 101 AAGCTGTGGCGGCGCAATGC GATTTGACCG AGGGTTGCAC GCTGCCGGAC 151 GGAAGCCGCG TCCGCGCCGCCGCCGTTTCA ACCAAAAAAC CGTTTGATAT 201 TTATATCGAA CACGCGCCCG CCGGCACGGAACAGGTCAGC ATCAGCTTCA 251 GTATGAAAAA TATGGATATG GGTTTCAACC GCTATATGTTCGAGCGGCAA 301 CCGTCGGGGA CTTGGCAGGC AGTACGCATC CGCCTGCCCA TCTGTGTCGA351 AGGCAGGCGC GATTTTACGG CGGACATTAC AATCGGCAGC CGGACATTTC 401AGACGGCATT TACCGCCGAA TAAThis corresponds to the amino acid sequence <SEQ ID 1102; ORF 270.a>:

a270.pep 1 MNKNRKLLLA ALLLIAFAAV KLVLLQWWQA QQPQAVAAQC DLTEGCTLPD 51GSRVRAAAVS TKKPFDIYIE HAPAGTEQVS ISFSMKNMDM GFNRYMFERQ 101 PSGTWQAVRIRLPICVEGRR DFTADITIGS RTFQTAFTAE * m270/a270 99.3% identity in 140 aaoverlap         10        20        30        40        50        60m270.pep MNKNRKLLLAALLLIAFAAVKLVLLQWWQAXQPQAVAAQCDLTEGCTLPDGSRVRAAAVS|||||||||||||||||||||||||||||| ||||||||||||||||||||||||||||| a270MNKNRKLLLAALLLIAFAAVKLVLLQWWQAQQPQAVAAQCDLTEGCTLPDGSRVRAAAVS        10        20        30        40        50        60        70        80        90       100       110       120 m270.pepTKKPFDIYIEHAPAGTEQVSISFSMKNMDMGFNRYMFERQPSGTWQAVRIRLPICVEGRR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a270TKKPFDIYIEHAPAGTEQVSISFSMKNMDMGFNRYMFERQPSGTWQAVRIRLPICVEGRR        70        80        90       100       110       120       130       140 m270.pep DFTADITIGSRTFQTAFTAEX||||||||||||||||||||| a270 DFTADITIGSRTFQTAFTAEX        130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1103>:

g271.seq 1 atgttcagtt cgcggatggc gaggatttgg gcgacggggg taacgttgtg 51tatggtcagt ccgtgtccgg cgttgacgac caagcccaaa tcgccggcga 101 aatgcgcgccgttttggatg cgctcgaact gcctgatttg ttcggcgtgg 151 ctttgtgcgt cggcatatgcgccggtgtgc agctcgacaa cgggcgcgcc 201 gacatcacgg gcggcttgga tttgcctgtcgtcggcatcg ataaacaagg 251 acacgcgtat gcccgcgtcg gtcaggattt tggcgaattcggcgattttt 301 tcctgttgcg ccaatacgtc caaaccgcct tcggtcgtga tttcctgccg351 tttttcaggc acgatgcaca cgtcttccgg catcacttta agcgcgtttt 401cgagcatttc ttccgtcaac gccatttcaa ggttcaggcg cgtgcggatg 451 gcgtttttgacggcaaatac atccgcgtct ttgatgtggc ggcggtcttc 501 gcgcaggtgc atggtaatcaggtctgcacc gtgcgtttcg gcaaccagtg 551 ccgcctccac ggggctggga taaThis corresponds to the amino acid sequence <SEQ ID 1104; ORF 271.ng>:

g271.pep 1 MFSSRMARIW ATGVTLCMVS PCPALTTKPK SPAKCAPFWM RSNCLICSAW 51LCASAYAPVC SSTTGAPTSR AAWICLSSAS INKDTRMPAS VRILANSAIF 101 SCCANTSKPPSVVISCRFSG TMHTSSGITL SAFSSISSVN AISRFRRVRM 151 AFLTANTSAS LMWRRSSRRCMVIRSAPCVS ATSAASTGLG *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1105>:

m271.seq 1 AwGTTCAGTT CGCGGATGGC GAGGATTTGG GCGATGGGGG TAACGTTGTG 51TATGGTCAGT CCGTGTCCGG CGTTGACGAC CAAGCCCAAA TCGCCGGCGA 101 AATGCGCGCCGTTTTGGATG CGCTCGAACT GCCTGATTTG TTCGGCGTGG 151 CTGCGCGCGT CGGCATACGCGCCTGTGTGC AGCTCGACAA CGGGCGCGCC 201 GACATCACGG GCGGCTTGGA TTTGCCTGTCGTCGGCATCG ATAAACAAAG 251 ACACGCGTAT GCCTGCGTCG GTCAGGATTT TGGTGAACCCGGCGATTTTT 301 TCCTGTTGCG CCAATACGTC CAAACCGCCT TCGGTCGTGA TTTCCTGACG351 TTTTTCAGGC ACGATGCACA CGTCTTCCGG CATCACTTTC AAAGCGTTTT 401CCAACATTTC TTCCGTCAAC GCCATTTCAA GGTTCAGGCG CGTGCGGATG 451 GCGTTTTTGACGGCAAACAC GTCCGCGTCT TTGATGTGGC GGCGGTCTTC 501 GCGCAGGTGC ATGGTAATCAAATCCGCACC GTGCGTTTCG GCAACCAGTG 551 CCGCCTCCAC GGGGCTGGGA TAAThis corresponds to the amino acid sequence <SEQ ID 1106; ORF 271>:

m271.pep 1 XFSSRMARIW AMGVTLCMVS PCPALTTKPK SPAKCAPFWM RSNCLICSAW 51LRASAYAPVC SSTTGAPTSR AAWICLSSAS INKDTRMPAS VRILVNPAIF 101 SCCANTSKPPSVVISXRFSG TMHTSSGITF KAFSNISSVN AISRFRRVRM 151 AFLTANTSAS LMWRRSSRRCMVIKSAPCVS ATSAASTGLG *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 271 shows 95.2% identity over a 189 aa overlap with a predicted ORF(ORF 271.ng) from N. gonorrhoeae:

m271/g271         10        20        30        40        50        60m271.pep XFSSRMARIWAMGVTLCMVSPCPALTTKPKSPAKCAPFWMRSNCLICSAWLRASAYAPVC |||||||||| ||||||||||||||||||||||||||||||||||||||| |||||||| g271MFSSRMARIWATGVTLCMVSPCPALTTKPKSPAKCAPFWMRSNCLICSAWLCASAYAPVC        10        20        30        40        50        60        70        80        90       100       110       120 m271.pepSSTTGAPTSRAAWICLSSASINKDTRMPASVRILVNPAIFSCCANTSKPPSVVISXRFSG||||||||||||||||||||||||||||||||||:| |||||||||||||||||| |||| g271SSTTGAPTSRAAWICLSSASINKDTRMPASVRILANSAIFSCCANTSKPPSVVISCRFSG        70        80        90       100       110       120       130       140       150       160       170       180 m271.pepTMHTSSGITFKAFSNISSVNAISRFRRVRMAFLTANTSASLMWRRSSRRCMVIKSAPCVS|||||||||::|||:||||||||||||||||||||||||||||||||||||||:|||||| g271TMHTSSGITLSAFSSISSVNAISRFRRVRMAFLTANTSASLMWRRSSRRCMVIRSAPCVS       130       140       150       160       170       180        190m271.pep ATSAASTGLGX ||||||||||| g271 ATSAASTGLGX        190The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1107>:

a271.seq 1 ATGTTCAGTT CGCGGATGGC GAGGATTTGG GCGATGGGGG TAACGTTGTG 51TATGGTCAGT CCGTGTCCGG CGTTGACGAC CAAGCCCAAA TCGCTGGCAA 101 AATGCGCGCCGTTTTGGATG CGCTCGAACT GCCTGATTTG TTCGGCGTGG 151 CTGCGCGCGT CGGCATACGCGCCTGTGTGC AGCTCGACAA CGGGCGCGCC 201 GACATCACGG GCGGCTTGGA TTTGCCTGTCGTCGGCATCG ATAAACAAGG 251 ACACGCGTAT GCCCGCGTCG GTCAGGATTT TGGTGAATTCGGCAATTTTG 301 TCTTGTTGCG CCAATACGTC CAAGCCGCCT TCGGTCGTGA TTTCCTGACG351 TTTTTCCGGC ACGATGCACA CGTCTTCCGG CATCACTTTA AGCGCGTTTT 401CGAGCATTTC TTCCGTCAAC GCCATTTCAA GGTTCAGGCG CGTGCGGATG 451 GCGTTTTTGACAGCAAACAC GTCCGCGTCT TTGATGTGGC GGCGGTCTTC 501 GCGCAGGTGC ATGGTAATCAGGTCGGCACC GTGCGTTTCG GCAACCAGTG 551 CCGCCTCCAC GGGGCTGGGA TAAThis corresponds to the amino acid sequence <SEQ ID 1108; ORF 271.a>:

a271.pep 1 MFSSRMARIW AMGVTLCMVS PCPALTTKPK SLAKCAPFWM RSNCLICSAW 51LRASAYAPVC SSTTGAPTSR AAWICLSSAS INKDTRMPAS VRILVNSAIL 101 SCCANTSKPPSVVIS*RFSG TMHTSSGITL SAFSSISSVN AISRFRRVRM 151 AFLTANTSAS LMWRRSSRRCMVIRSAPCVS ATSAASTGLG * m271/a271 96.3% identity in 189 aa overlap        10        20        30        40        50        60 m271.pepXFSSRMARIWAMGVTLCMVSPCPALTTKPKSPAKCAPFWMRSNCLICSAWLRASAYAPVC |||||||||||||||||||||||||||||| |||||||||||||||||||||||||||| a271MFSSRMARIWAMGVTLCMVSPCPALTTKPKSLAKCAPFWMRSNCLICSAWLRASAYAPVC        10        20        30        40        50        60        70        80        90       100       110       120 m271.pepSSTTGAPTSRAAWICLSSASINKDTRMPASVRILVNPAIFSCCANTSKPPSVVISXRFSG|||||||||||||||||||||||||||||||||||| ||:|||||||||||||||||||| a271SSTTGAPTSRAAWICLSSASINKDTRMPASVRILVNSAILSCCANTSKPPSVVISXRFSG        70        80        90       100       110       120       130       140       150       160       170       180 m271.pepTMHTSSGITFKAFSNISSVNAISRFRRVRMAFLTANTSASLMWRRSSRRCMVIKSAPCVS|||||||||::|||:||||||||||||||||||||||||||||||||||||||:|||||| a271TMHTSSGITLSAFSSISSVNAISRFRRVRMAFLTANTSASLMWRRSSRRCMVIRSAPCVS       130       140       150       160       170       180        190m271.pep ATSAASTGLGX ||||||||||| a271 ATSAASTGLGX        190The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1109>:

g272.seq 1 atgactgcaa aggaagaact gttcgcatgg ctgcgccata tgaacaaaaa 51caaaggttcc gacctgtttg tgacgaccca tttcccgccc gctatgaagc 101 tggacggcaaaatcacccgc atcacggacg aaccgctgac ggcggaaaaa 151 tgtatggaaa tcgccttttcgattatgagt gcgaagcagg cggaagaatt 201 ttcatcgacc aacgagtgca atttcgccatcagcctgccg gacaccagcc 251 gcttccgcgt caatgcgatg atacagcgcg gtgcgacggcgttggtattc 301 cgcgcgatta ccagcaagat tcccaagttt gaaagcctga acctgccgcc351 ggccttgaag gatgttgcgc tgaaaaaacg cgggctggtt atttttgtcg 401gcggcaccgg ctcgggcaaa tcgacttcgc tcgcctcgct tatcgactac 451 cgcaatgaaaattcgttcgg acacatcatc accatcgaag atccgatcga 501 gtttgtccac gaacacaaaaactgcatcat tacccagcgc gaggtcggcg 551 tggacacgga aaactggatg gcggcgttgaaaaatacgct gcgtcaggcg 601 ccggatgtga tccttatcgg cgaaatccgc gaccgtgaaacaatggacta 651 cgccatcgcc tttgccgaaa cggggcattt gtgtatggcg acgctgcacg701 ccaacagcac caatcaggcg ctcgaccgca tcatcaactt cttccccgag 751gagcggcgcg aacaattgct gacggatttg tcgctcaacc ttcaggcgtt 801 tatttcgcaacgcctcgttc cgcgagacgg cggcaagggc agggtggcgg 851 cagtcgaggt gctgctcaattcgcccctga tttcggagtt gattcacaac 901 ggcaacatcc atgaaatcaa agaagtgatgaaaaaatcca ctaccctggg 951 tatgcagacc ttcgaccaac acctttacca attgtatgaaaaaggcgaga 1001 tttccttgca ggatgccttg aaaaatgccg attccgcaca tgatttgcgt1051 ttggcggtac agttgcgcag ccgcagggca caaagttccg accccgattt 1101ggaactgctc tgaThis corresponds to the amino acid sequence <SEQ ID 1110; ORF 272.ng>:

g272.pep 1 MTAKEELFAW LRHMNKNKGS DLFVTTHFPP AMKLDGKITR ITDEPLTAEK 51CMEIAFSIMS AKQAEEFSST NECNFAISLP DTSRFRVNAM IQRGATALVF 101 RAITSKIPKFESLNLPPALK DVALKKRGLV IFVGGTGSGK STSLASLIDY 151 RNENSFGHII TIEDPIEFVHEHKNCIITQR EVGVDTENWM AALKNTLRQA 201 PDVILIGEIR DRETMDYAIA FAETGHLCMATLHANSTNQA LDRIINFFPE 251 ERREQLLTDL SLNLQAFISQ RLVPRDGGKG RVAAVEVLLNSPLISELIHN 301 GNIHEIKEVM KKSTTLGMQT FDQHLYQLYE KGEISLQDAL KNADSAHDLR351 LAVQLRSRRA QSSDPDLELL *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1111>:

m272.seq 1 ATGACCGCAA AGGAAGAACT GTTCGCATGG CTGCGCCATA TGAwCCAAAA 51CAAAGGTTCC GACCTGTTCG TGACAACCCA TTTCCCGCCC GCAATGAAGC 101 TGGACGGCAAAATCACCCGC ATCACGGACG AACCGCTGAC GGCGGAAAAA 151 TGTATGGAAA TCGCCTTTTCGATTATGAGT GCGAAGCAGG CGGAAGAATT 201 TTCATCGACC AACGAGTGCA ACTTCGCCATCAGCCTGCCG GACACCAGCC 251 GCTTCCGCGT CAATGCGATG ATACAGCgCG GCGCGACGGCGTTGGTATTC 301 CGTACGATTA CCAGCAAGAT TCCCAAGTTT GAAAGCCTGA ACCTGCCGCC351 AGTCTTGAAG GATGTCGCGC TGAAAAAACG CGGGCTGGTT ATTTTTGTCG 401GCGGCACCGG CTCGGGTAAA TCGACTTCGC TTGCCTCGCT TATCGACTAC 451 CGCAATGAAAATTCGTTCGG ACACATCATC ACCATCGAAG ACCCGATCGA 501 GTTTGTCCAC GAACACAAAAACTGCATCAT CACCCAGCGC GAGGTCGGCG 551 TGGATACGGA AAACTGGATG GcGGCGTTGAAAAACACGCT GCGTCAGGCG 601 CCTGATGTCA TCCTTATCGG CGAAATCCGT GACCGCGAAACAATGGACTA 651 CGCCATTGCC TTTGCCGAAA CGGGGCATTT GTGTATGGCG ACGCTGCACG701 CCAACAGCAC CAATCAGGCA CTCGACCGCA TCATCAACTT TTTCCCCGAG 751GAGCGGCGCG AACAATTGCT GACGGATTTG TCGCTCAACC TTCAGGCGTT 801 TATTTCGCAACGCCTCGTTC CGCGAGACGG CGGCAAGGGC AGGGTGGCGG 851 CAGTCGAGGT GCTGCTCAATTCGCCCCtGA TTTCGGAGTT GATTCACAAC 901 GGCAACATCC ATGAAATCAA AGAAGTGATGAAAAAATCCA CTACCCTGGG 951 TATGCAGACC TTCGATCAAC ACCTTTACCA ATTGTATGAAAAAGGCGATA 1001 TTTCCCTGCA AGAAGCATTG AAAAATGCCG ATTCCGCACA CGATTTGCGT1051 TTGGCGGTAC AGTTGCGCAG CCGCCGCGCG CAaAGTTyCA GCCCCGATTT 1101GGnACTGCTC TGAThis corresponds to the amino acid sequence <SEQ ID 1112; ORF 272>:

m272.pep 1 MTAKEELFAW LRHMXQNKGS DLFVTTHFPP AMKLDGKITR ITDEPLTAEK 51CMEIAFSIMS AKQAEEFSST NECNFAISLP DTSRFRVNAM IQRGATALVF 101 RTITSKIPKFESLNLPPVLK DVALKKRGLV IFVGGTGSGK STSLASLIDY 151 RNENSFGHII TIEDPIEFVHEHKNCIITQR EVGVDTENWM AALKNTLRQA 201 PDVILIGEIR DRETMDYAIA FAETGHLCMATLHANSTNQA LDRIINFFPE 251 ERREQLLTDL SLNLQAFISQ RLVPRDGGKG RVAAVEVLLNSPLISELIHN 301 GNIHEIKEVM KKSTTLGMQT FDQHLYQLYE KGDISLQEAL KNADSAHDLR351 LAVQLRSRRA QSXSPDLXLL *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 272 shows 97.6% identity over a 370 aa overlap with a predicted ORF(ORF 272.ng) from N. gonorrhoeae:

m272/g272         10        20        30        40        50        60m272.pep MTAKEELFAWLRHMXQNKGSDLFVTTHFPPAMKLDGKITRITDEPLTAEKCMEIAFSIMS|||||||||||||| :|||||||||||||||||||||||||||||||||||||||||||| g272MTAKEELFAWLRHMNKNKGSDLFVTTHFPPAMKLDGKITRITDEPLTAEKCMEIAFSIMS        10        20        30        40        50        60        70        80        90       100       110       120 m272.pepAKQAEEFSSTNECNFAISLPDTSRFRVNAMIQRGATALVFRTITSKIPKFESLNLPPVLK|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||:|| g272AKQAEEFSSTNECNFAISLPDTSRFRVNAMIQRGATALVFRAITSKIPKFESLNLPPALK        70        80        90       100       110       120       130       140       150       160       170       180 m272.pepDVALKKRGLVIFVGGTGSGKSTSLASLIDYRNENSFGHIITIEDPIEFVHEHKNCIITQR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g272DVALKKRGLVIFVGGTGSGKSTSLASLIDYRNENSFGHIITIEDPIEFVHEHKNCIITQR       130       140       150       160       170       180       190       200       210       220       230       240 m272.pepEVGVDTENWMAALKNTLRQAPDVILIGEIRDRETMDYAIAFAETGHLCMATLHANSTNQA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g272EVGVDTENWMAALKNTLRQAPDVILIGEIRDRETMDYAIAFAETGHLCMATLHANSTNQA       190       200       210       220       230       240       250       260       270       280       290       300 m272.pepLDRIINFFPEERREQLLTDLSLNLQAFISQRLVPRDGGKGRVAAVEVLLNSPLISELIHN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g272LDRIINFFPEERREQLLTDLSLNLQAFISQRLVPRDGGKGRVAAVEVLLNSPLISELIHN       250       260       270       280       290       300       310       320       330       340       350       360 m272.pepGNIHEIKEVMKKSTTLGMQTFDQHLYQLYEKGDISLQEALKNADSAHDLRLAVQLRSRRA||||||||||||||||||||||||||||||||:||||:|||||||||||||||||||||| g272GNIHEIKEVMKKSTTLGMQTFDQHLYQLYEKGEISLQDALKNADSAHDLRLAVQLRSRRA       310       320       330       340       350       360        370m272.pep QSXSPDLXLLX || :||| ||| g272 QSSDPDLELLX        370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1113>:

a272.seq 1 ATGACCGCAA AGGAAGAACT GTTCGCATGG CTGCGCCATA TGAACAAAAA 51CAAAGGTTCC GACCTGTTCG TGACGACCCA TTTCCCGCCC GCAATGAAGC 101TGGACGGCAA AATCACCCGC ATCACGGACG AACCGCTGAC GGCGGAAAAA 151TGTATGGAAA TCGCCTTTTC GATTATGAGT GCGAAGCAGG CGGAAGAATT 201TTCATCGACC AACGAGTGCA ACTTCGCCAT CAGTCTGCCG GACACCAGCC 251GCTTCCGCGT CAATGCGATG ATACAGCGCG GTGCGACGGC GTTGGTATTC 301CGTGCGATTA CCAGCAAGAT TCCCAAGTTT GAAAGCCTGA ACCTGCCGCC 351GGTCTTGAAG GATGTCGCGC TGAAAAAACG CGGGCTGGTT ATTTTTGTCG 401GCGGCACCGG CTCGGGCAAA TCGACTTCGC TTGCCTCGCT TATCGACTAC 451CGCAATGAAA ATTCGTTCGG ACACATCATC ACCATCGAAG ACCCGATCGA 501GTTTGTCCAC GAACACAAAA ACTGCATCAT CACCCAGCGC GAGGTCGGCG 551TGGATACGGA AAACTGGATG GCGGCGTTGA AAAACACGCT GCGTCAGGCA 601CCGGATGTGA TTCTGATCGG CGAAATCCGC GACCGCGAAA CAATGGACTA 651CGCCATTGCT TTTGCCGAAA CGGGGCATTT GTGTATGGCG ACGCTGCACG 701CCAACAGCAC CAATCAGGCA CTCGACCGCA TCATCAACTT TTTCCCCGAG 751GAGCGGCGCG AACAATTGCT GACGGATTTG TCGCTCAACC TTCAGGCATT 801TATTTCGCAA CGCCTCGTTC CGCGAGACGG CGGCAAGGGC AGGGTGGCGG 851CAGTCGAGGT GCTGCTCAAT TCGCCCCTGA TTTCGGAGTT GATTCACAAC 901GGCAATATCC ATGAAATCAA AGAAGTGATG AAAAAATCCA CTACCCTGGG 951TATGCAGACT TTCGACCAAC ACCTTTACCA ATTGTATGAA AAAGGCGAGA 1001TTTCCTTGCA GGATGCCTTG AAAAATGCCG ATTCCGCACA CGATTTGCGT 1051TTGGCGGTAC AGTTGCGCAG CCGCCAGGCG CAAAGTTCCG GTCCCGATTT 1101GGAACTGCTC TGAThis corresponds to the amino acid sequence <SEQ ID 1114; ORF 272.a>:

a272.pep 1 MTAKEELFAW LRHMNKNKGS DLFVTTHFPP AMKLDGKITR ITDEPLTAEK 51CMEIAFSIMS AKQAEEFSST NECNFAISLP DTSRFRVNAM IQRGATALVF 101RAITSKIPKF ESLNLPPVLK DVALKKRGLV IFVGGTGSGK STSLASLIDY 151RNENSFGHII TIEDPIEFVH EHKNCIITQR EVGVDTENWM AALKNTLRQA 201PDVILIGEIR DRETMDYAIA FAETGHLCMA TLHANSTNQA LDRIINFFPE 251ERREQLLTDL SLNLQAFISQ RLVPRDGGKG RVAAVEVLLN SPLISELIHN 301GNIHEIKEVM KKSTTLGMQT FDQHLYQLYE KGEISLQDAL KNADSAHDLR 351LAVQLRSRQA QSSGPDLELL * m272/a272 97.6% identity in 370 aa overlap        10        20        30        40        50        60 m272.pepMTAKEELFAWLRHMXQNKGSDLFVTTHFPPAMKLDGKITRITDEPLTAEKCMEIAFSIMS|||||||||||||| :|||||||||||||||||||||||||||||||||||||||||||| a272MTAKEELFAWLRHMNKNKGSDLFVTTHFPPAMKLDGKITRITDEPLTAEKCMEIAFSIMS        10        20        30        40        50        60        70        80        90       100       110       120 m272.pepAKQAEEFSSTNECNFAISLPDTSRFRVNAMIQRGATALVFRTITSKIPKFESLNLPPVLK|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| a272AKQAEEFSSTNECNFAISLPDTSRFRVNAMIQRGATALVFRAITSKIPKFESLNLPPVLK        70        80        90       100       110       120       130       140       150       160       170       180 m272.pepDVALKKRGLVIFVGGTGSGKSTSLASLIDYRNENSFGHIITIEDPIEFVHEHKNCIITQR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a272DVALKKRGLVIFVGGLGSGKSTSLASLIDYRNENSFGHIITIEDPIEFVHEHKNCIITQR       130       140       150       160       170       180       190       200       210       220       230       240 m272.pepEVGVDTENWMAALKNTLRQAPDVILIGEIRDRETMDYAIAFAELGHLCMATLHANSTNQA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a272EVGVDTENWMAALKNTLRQAPDVILIGEIRDRETMDYAIAFAELGHLCMATLHANSTNQA       190       200       210       220       230       240       250       260       270       280       290       300 m272.pepLDRIINFFPEERREQLLTDLSLNLQAFISQRLVPRDGGKGRVAAVEVLLNSPLISELIHN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a272LDRIINFFPEERREQLLTDLSLNLQAFISQRLVPRDGGKGRVAAVEVLLNSPLISELIHN       250       260       270       280       290       300       310       320       330       340       350       360 m272.pepGNIHEIKEVMKKSTTLGMQTFDQHLYQLYEKGDISLQEALKNADSAHDLRLAVQLRSRRA||||||||||||||||||||||||||||||||:||||:||||||||||||||||||||:| a272GNIHEIKEVMKKSTTLGMQTFDQHLYQLYEKGEISLQDALKNADSAHDLRLAVQLRSRQA       310       320       330       340       350       360        370m272.pep QSXSPDLXLLX || :||| ||| a272 QSSGPDLELLX        370The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1115>:

g273.seq 1 atgagtcttc aggcggtatt tatatacccc ccaagccgta ccgcacaata 51caacgaaaat caggaaaacg gcggtaaagc tcataaacag ggacaaagcg 101gcaaacacac cgaccgccgt caggatatag gcgtattcga ggccggaact 151ccattcaccg ttttcctgcc gtttcttgtc gcttttgaaa taaaggatga 201tgccggcaag cagcgcggca gccgcgcccg acattggcat tgtgttcatt 251gttgttcctt aacggttaaa aacccgcccg gccgtgcaac cgttttaagg 301cgggaaattg caaaatttgt ttgcgggcgc gtgccgctga aatcaaggcg 351gtttgagaag tgtttccnac gcgcccgccc tatgtgccga aatattattt 401gtcgctcacc tgcaaaatcg ccaagaacgc gctttgcgga atttccacgt 451tgcccacttg tttcatacgg cgtttgcctg ctttttgttt ttcaagcagt 501tttttcttac gcgtaaThis corresponds to the amino acid sequence <SEQ ID 1116; ORF 273.ng>:

g273.pep 1 MSLQAVFIYP PSRTAQYNEN QENGGKAHKQ GQSGKHTDRR QDIGVFEAGT 51PFTVFLPFLV AFEIKDDAGK QRGSRARHWH CVHCCSLTVK NPPGRATVLR 101REIAKFVCGR VPLKSRRFEK CFXRARPMCR NIICRSPAKS PRTRFAEFPR 151CPLVSYGVCL LFVFQAVFSY A*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1117>:

m273.seq 1 ATGAGTCTTC AGGCGGTATT TATATACCCm CCAAGCCGTA CCGCACAATA 51CAACGAAAAT CAGGAAAACG GCGGTAAAGC TCAyAAACAG GGACAAAGCG 101GCAAACACGC CGACCGCTGT CAGGATATAG GCGTATTCAA GGCCGGAACT 151CCATTCCCCG TTTTCCTGCC GCTTCTTGTC GCTTTTGAAA TAAAGGATGA 201TGCCGGCAAG CAGCGCGGCA GCCGCGCCCG ACATTAGCAT TGTGTTCATT 251GTTGTTCCTT AATGCTTAAA AACCCGCCTG TCCGTGCAAC CGTTTTAAGG 301CGGCAAATTG CAAAATTTGT TTGCGGGCGC GTGCCCCTGA AATCAGGGCG 351GTTTGAGGGG TGTTCCCGAC GCGCCGCCCT GTGTGCCGGA GTTATTTGTC 401GCTCACCTGC AAAATCGCCA AGAACGCGCT TTGCGGAATT TCCACATTGC 451CCACTTGTTT CATACGGCGT TTACCTGCCT TTTGTkTwTC AAGCAGTTTT 501TTCTTACGCG TAAThis corresponds to the amino acid sequence <SEQ ID 1118; ORF 273>:

m273.pep 1 MSLQAVFIYP PSRTAQYNEN QENGGKAHKQ GQSGKHADRC QDIGVFKAGT 51PFPVFLPLLV AFEIKDDAGK QRGSRARH*H CVHCCSLMLK NPPVRATVLR 101RQIAKFVCGR VPLKSGRFEG CSRRAALCAG VICRSPAKSP RTRFAEFPHC 151PLVSYGVYLP FVXQAVFSYA *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 273 shows 86.0% identity over a 171 aa overlap with a predicted ORF(ORF 273.ng) from N. gonorrhoeae:

m273/g273         10        20        30        40        50        60m273.pep MSLQAVFIYPPSRTAQYNENQENGGKAHKQGQSGKHADRCQDIGVFKAGTPFPVFLPLLV||||||||||||||||||||||||||||||||||||:|| ||||||:||||| ||||:|| g273MSLQAVFIYPPSRTAQYNENQENGGKAHKQGQSGKHTDRRQDIGVFEAGTPFTVFLPFLV        10        20        30        40        50        60        70        80        90       100       110       120 m273.pepAFEIKDDAGKQRGSRARHXHCVHCCSLMLKNPPVRATVLRRQIAKFVCGRVPLKSGRFEG|||||||||||||||||| |||||||| :|||| |||||||:||||||||||||| ||| g273AFEIKDDAGKQRGSRARHWHCVHCCSLTVKNPPGRATVLRREIAKFVCGRVPLKSRRFEK        70        80        90       100       110       120        130       140       150       160       170 m273.pepCSRRA-ALCAGVICRSPAKSPRTRFAEFPHCPLVSYGVYLPFVXQAVFSYAX |  ||  :|::|||||||||||||||||:|||||||| | || |||||||| g273CFXRARPMCRNIICRSPAKSPRTRFAEFPRCPLVSYGVCLLFVFQAVFSYAX       130       140       150       160       170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1119>:

a273.seq 1 ATGAGTCTTC AGGCGGTATT TGTATACCCC CCAAGCCGTA CCGCACAATA 51CAACGAAAAT CAGGAAAACG GCGGTAAAGC TCATAAACAG GGACAAAGCG 101GCAAACACGC CGACCGCCGT CAGGATATAG GCGTATTCCA GACCGGAACT 151CCATTCACCG TTTTCCTGCC GCTTTTTGTC GCTTTTGAAA TAAAGGATGA 201TGCCGGCAAG CAGCGCGGCA GCCGCGCCCG ACATTAGCAT AATGTTCATT 251GTTGTTCCTT AACGGTTAAA AACCCGCCCG TCCGTGCAAC CGTTTTTAAG 301AGGCGGTAAA TCACAAAGTT TGTTGGCGGA CGTGCTCTCT TACAATCAGG 351GCGGTTTAAG GGGCATGATG CACTGCCCCG TGTGCCGGAT ATTATTTGTC 401GCTCACCTGC AAAATTGCCA AGAACGCGCT TTGCGGGATT TCCACATTGC 451CCACTTGTTT CATACGGCGT TTGCCTGCTT TTTGTTTTTC AAGCAGTTTT 501TTCTTACGCG TAAThis corresponds to the amino acid sequence <SEQ ID 1120; ORF 273.a>:

a273.pep 1 MSLQAVFVYP PSRTAQYNEN QENGGKAHKQ GQSGKHADRR QDIGVFQTGT 51PFTVFLPLFV AFEIKDDAGK QRGSRARH*H NVHCCSLTVK NPPVRATVFK 101RR*ITKFVGG RALLQSGRFK GHDALPRVPD IICRSPAKLP RTRFAGFPHC 151PLVSYGVCLL FVFQAVFSYA * m273/a273 80.1% identity in 171 aa overlap          10        20        30        40        50        60 m273.pep  MSLQAVFIYPPSRTAQYNENQENGGKAHKQGQSGKHADRCQDIGVFKAGTPFPVFLPLLV  |||||||:||||||||||||||||||||||||||||||| ||||||::|||| |||||:| a273  MSLQAVFVYPPSRTAQYNENQENGGKAHKQGQSGKHADRRQDIGVFQTGTPFTVFLPLFV          10        20        30        40        50        60          70        80        90        100       110      119 m273.pep  AFEIKDDAGKQRGSRARHXHCVHCCSLMLKNPPVRATVL-RRQIAKFVCGRVPLKSGRFE  |||||||||||||||||||| |||||| :|||||||||: || |:||| ||: |:||||: a273  AFEIKDDAGKQRGSRARHXHNVHCCSLTVKNPPVRATVFKRRXITKFVGGRALLQSGRFK          70        80        90       100       110       120120       130       140       150       160       170 m273.pep  GCSRRAALCAGVICRSPAKSPRTRFAEFPHCPLVSYGVYLPFVXQAVFSYAX   |:    :   :||||||| |||||| ||||||||||| | || |||||||| a273  GHDALPRV-PDIICRSPAKLPRTRFAGFPHCPLVSYGVCLLFVFQAVFSYAX          130       140       150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1121>:

g274.seq 1 ATGGCGGGGC CGATTTTTGT CGTCatCGCC AgcgTCGCTA TGTTTTTTGT 51CGCGCAGCAG CACGCGACAG ATTTGGTTAC GGACGATTAT TATAAGGATG 101GCAAGCATAT CGACATCCAG CTTCATCGGG ATGAAGAAGC CGTCAGACGG 151CATATCGGGG TGCAGGTCCT CATTTCTCCC GATATGAATG CGGCAAAAGT 201GTTTGTCGGc ggCgagtTTG ACGGCAAACA GCCTTTGAAC CTGCTGCTGA 251TGCACCCGAC CCGCAAGGCG GACGATCAAA CCGTCGCCCT CAAGCCCGTC 301GGCAGCGCGC AGAACGGCAG GGCGGAATAT GAGGCGGTgt tcaaAACCCT 351TCCGCCGGCC AACCACTGGT ATGTGCGCGT GGAggacgCG GCAGGCGTGT 401GGCGCGTCGA GAACAAATGG ATTACCAGCC AGGGCAATGC GGTCGATTTG 451ACCCCGATGG ACAAACTTTT CAATAATGCA GGAAGCAAAT AAThis corresponds to the amino acid sequence <SEQ ID 1122; ORF 274.ng>:

g274.pep 1 MAGPIFVVIA SVAMFFVAQQ HATDLVTDDY YKDGKHIDIQ LHRDEEAVRR 51HIGVQVLISP DMNAAKVFVG GEFDGKQPLN LLLMHPTRKA DDQTVALKPV 101GSAQNGRAEY EAVFKTLPPA NHWYVRVEDA AGVWRVENKW ITSQGNAVDL 151TPMDKLFNNA GSK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1123>:

m274.seq 1 ATGGCGGGGC CGATTTTTGT CGTCATCGCC AGCGTCGCTA TGTTTTTTGT 51CGCGCAGCAG CACGCGACAG ATTTGGTTAC GGACGATTAT TATAAAGACG 101GCAAACATAT CGACATCCAG CTTCATCGGG ATGAAGAAGC CGTCAGACGG 151CATATCGGGG TGCAGGTTCT CATTTCCCCC GATATGAATG CGGCAAAAGT 201GTTTGTCGGC GGCGAGTTTG ACGGCAAACA GCCTTTGAAC CTGCTGCTGA 251TGCACCCGAC CCGCAAGGCG GACGATCAAA CCGTCGCCCT CAAGCCCGTC 301GGCAGCGCGC AGAACGGCAG GGCGGAATAT GAGGCGGTGT TCAAAACCCT 351TTCGCCGACC AACCACTGGT ATGTGCGCGT GGAGGACGCG GCAGGCGTGT 401GGCGCGTCGA GAACAAATGG ATTACCAGCC AAGGCAATGC GGTCGATTTG 451ACCCCGATGG ACAAGCTTTT CAATAATACT GAAAGCAAAT AAThis corresponds to the amino acid sequence <SEQ ID 1124; ORF 274>:

m274.pep 1 MAGPIFVVIA SVAMFFVAQQ HATDLVTDDY YKDGKHIDIQ LHRDEEAVRR 51HIGVQVLISP DMNAAKVFVG GEFDGKQPLN LLLMHPTRKA DDQTVALKPV 101GSAQNGRAEY EAVFKTLSPT NHWYVRVEDA AGVWRVENKW ITSQGNAVDL 151TPMDKLFNNT ESK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 274 shows 97.5% identity over a 163 aa overlap with a predicted ORF(ORF 274.ng) from N. gonorrhoeae:

g274/m274         10        20        30        40        50        60g274.pep MAGPIFVVIASVAMFFVAQQHATDLVTDDYYKDGKHIDIQLHRDEEAVRRHIGVQVLISP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m274MAGPIFVVIASVAMFFVAQQHATDLVTDDYYKDGKHIDIQLHRDEEAVRRHIGVQVLISP        10        20        30        40        50        60        70        80        90       100       110       120 g274.pepDMNAAKVFVGGEFDGKQPLNLLLMHPTRKADDQTVALKPVGSAQNGRAEYEAVFKTLPPA||||||||||||||||||||||||||||||||||||||||||||||||||||||||| |: m274DMNAAKVFVGGEFDGKQPLNLLLMHPTRKADDQTVALKPVGSAQNGRAEYEAVFKTLSPT        70        80        90       100       110       120       130       140       150       160 g274.pepNHWYVRVEDAAGVWRVENKWITSQGNAVDLTPMDKLFNNAGSKX|||||||||||||||||||||||||||||||||||||||: ||| m274NHWYVRVEDAAGVWRVENKWITSQGNAVDLTPMDKLFNNTESKX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1125>:

a274.seq 1 ATGGCGGGGC CGATTTTTGT CGTCATCGCC AGCGTCGCTA TGTTTTTTGT 51CGCGCAGCAG CACGCGACAG ATTTGGTTAC GGACGATTAT TATAAAGACG 101 GCAAGCATATCGACATCCAG CTTCATCGGG ATGAAGAAGC CGTCAGACGG 151 CATATCGGGG TGCAGGTTCTCATTTCCCCC GATATGAATG CGGCAAAAGT 201 GTTTGTCGGC GGCGAGTTTG ACGGCAAACAGCCTTTGAAC CTGCTGCTGA 251 TGCACCCGAC CCGCAAGGCG GACGATCAAA CCGTCGCCCTCAAGCCCGTC 301 GGCAGCGCGC AGAACGGCAG GGCGGAATAT GAGGCGGTGT TCAAAACCCT351 TTCGCCGACC AACCACTGGT ATGTGCGCGT GGAGGACGCG GCAGGCGTGT 401GGCGCGTCGA GAACAAATGG ATTACCAGCC AAGGCAATGC GGTCGATTTG 451 ACCCCGATGGACAAACTTTT CAATAATACT GAAAGCAAAT AAThis corresponds to the amino acid sequence <SEQ ID 1126; ORF 274.a>:

a274.pep 1 MAGPIFVVIA SVAMFFVAQQ HATDLVTDDY YKDGKHIDIQ LHRDEEAVRR 51HIGVQVLISP DMNAAKVFVG GEFDGKQPLN LLLMHPTRKA DDQTVALKPV 101 GSAQNGRAEYEAVFKTLSPT NHWYVRVEDA AGVWRVENKW ITSQGNAVDL 151 TPMDKLFNNT ESK*m274/a274 100.0% identity in 163 aa overlap        10        20        30        40        50        60 m274.pepMAGPIFVVIASVAMFFVAQQHATDLVTDDYYKDGKHIDIQLHRDEEAVRRHIGVQVLISP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a274MAGPIFVVIASVAMFFVAQQHATDLVTDDYYKDGKHIDIQLHRDEEAVRRHIGVQVLISP        10        20        30        40        50        60        70        80        90       100       110       120 m274.pepDMNAAKVFVGGEFDGKQPLNLLLMHPTRKADDQTVALKPVGSAQNGRAEYEAVEKTLSPT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a274DMNAAKVFVGGEFDGKQPLNLLLMHPTRKADDQTVALKPVGSAQNGRAEYEAVEKTLSPT        70        80        90       100       110       120       130       140       150       160 m274.pepNHWYVRVEDAAGVWRVENKWITSQGNAVDLTPMDKLFNNTESKX|||||||||||||||||||||||||||||||||||||||||||| a274NHWYVRVEDAAGVWRVENKWITSQGNAVDLTPMDKLFNNTESKX       130       140       150       160The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 1127>:

g276.seq 1 atgattttgc cgccatccat gacgatgatg cggtcggcgg attcgacggt 51ggtcaggcgg tgggcgacga tgatgccggt gcggttttcc atcaggcgtt 101 cgagcgcttgttggacgagg cgttcggatt cgttgtccaa tgcgctggtg 151 gcttcgtcca ataataatatcggcgcgtct ttcaaaatgg cgcgggcgat 201 ggcgacgcgt tgccgctgtc cgccggataagttgctgccg ttcgatccga 251 tgggctggtg cagtccgagc ggggatgcgt cgatcaggctttgcaggttg 301 gcggcttgga gggcggacag gacttcggct tcgcccgcgt cgggacggct351 gtatcggacg ttttcaaaca gggtgtcgtc aaacaggaat acgtcttggg 401agacgagggc gaattgggcg cgcaggcagt cgagtttgat gtcggcgatg 451 tcgataccgtctatgcagat gttgccggca gacggttcga caaagcgggg 501 cagaaggttg acgacggtggatttgccgct gccggaacgt ccgaccaggg 551 cgacgcgttc gccttgtctg atgtcgaggttgaagttgtc gagggctttg 601 atgccgtctg aacggtattc gacatcgacg ttgcggaagctgatgcgccc 651 ttcgacacgc tgcggcgcga gcgtgccttt gtcctgttcg ggcggggtgt701 cgagaaatgc acatacgccg tcggcggcga ggaacatcgt ctgcataggg 751atgctgatgt tggcaaggct tttgatgggg gcgtacattt gcagcatcgc 801 gacgatgaatgccataaatt cgccgatggt ggtgtagThis corresponds to the amino acid sequence <SEQ ID 1128; ORF 276.ng>:

g276.pep 1 MILPPSMTMM RSADSTVVRR WATMMPVRFS IRRSSACWTR RSDSLSNALV 51ASSNNNIGAS FKMARAMATR CRCPPDKLLP FDPMGWCSPS GDASIRLCRL 101 AAWRADRTSASPASGRLYRT FSNRVSSNRN TSWETRANWA RRQSSLMSAM 151 SIPSMQMLPA DGSTKRGRRLTTVDLPLPER PTRATRSPCL MSRLKLSRAL 201 MPSERYSTST LRKLMRPSTR CGASVPLSCSGGVSRNAHTP SAARNIVCIG 251 MLMLARLLMG AYICSIATMN AINSPMVV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1129>:

m276.seq 1 ATGATTTTGC CGTCGTCCAT CACGATGATG CGGTCGGCCC CTTCGATGGT 51GGTCAGGCGG TGGGCGACGA TGATGCCGGT GCGGTTTTCC ATCAGGCGTT 101 CGAGCGCCTGTTGGACGAGG CGTTCGGATT CGTTGTCTAA TGCGCTGGTG 151 GCTTCGTCCA ATAATAATATCGGCGCGTCT TTCAAAATGG CGCGGGCAAT 201 GGCGACGCGT TGCCGCTGTC CGCCGGATAAGTTGCTGCCG TTCGATCCGA 251 TGGGCTGGTG CAGTCCGAGC GGGGAGCTGT CAATCAGGCTTTGCAGGTTG 301 GCGGTTTGGA GGGCGAACAG GACTTCGGCT TCGCCCGCGT CGGGACGGCT351 GTATCGGACG TTTTCAAACA GGGTGTCGTC AAACAGGAAT ACGTCTTGGG 401AGACGAGGGC GAATTGGGCG CGCAGGCAGT CGAGTTTGAT GTCGGCGATG 451 TCGATACCGTCTATGCAGAT GTTGCCGGCA GACGGTTCGA CAAAGCGGGG 501 CAGCAGGTTG ACGACGGTGGATTTGCCGCT GCCGGAACGT CCGACCAGGG 551 CGACGCGTTC GCCTTGTCTG ATGTCGAGGTTGAAGTTGTC GAGGGCTTTG 601 ATGCCGTCTG AACGGTATTC GACATCGACG TTGCGGAAGCTGATGCGCCC 651 TTCGACACGC TGCGGTGCGA GCGTGCCCTT GTCCTGTTCG GGCGGGGTGT701 CGAGAAATGC ACATACACCG TCGGCGGCGA GGAACATCGT CTGCATAGGG 751ATGCTGATGT TGGCAAGGCT TTTGATGGGG GCGTACATTT GCAGCATCGC 801 GACGATGAATGCCATAAATT CGCCGATGGT GGTGTAGThis corresponds to the amino acid sequence <SEQ ID 1130; ORF 276>:

m276.pep 1 MILPSSITMM RSAPSMVVRR WATMMPVRFS IRRSSACWTR RSDSLSNALV 51ASSNNNIGAS FKMARAMATR CRCPPDKLLP FDPMGWCSPS GELSIRLCRL 101 AVWRANRTSASPASGRLYRT FSNRVSSNRN TSWETRANWA RRQSSLMSAM 151 SIPSMQMLPA DGSTKRGSRLTTVDLPLPER PTRATRSPCL MSRLKLSRAL 201 MPSERYSTST LRKLMRPSTR CGASVPLSCSGGVSRNAHTP SAARNIVCIG 251 MLMLARLLMG AYICSIATMN AINSPMVV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 276 shows 96.8% identity over a 278 aa overlap with a predicted ORF(ORF 276.ng) from N. gonorrhoeae:

m276/g276         10        20        30        40        50        60m276.pep MILPSSITMMRSAPSMVVRRWATMMPVRFSIRRSSACWTRRSDSLSNALVASSNNNIGAS|||| |:|||||| | ||||||||||||||||||||||||||||||||||||||||||||| g276MILPPSMTMMRSADSTVVRRWATMMPVRFSIRRSSACWTRRSDSLSNALVASSNNNIGAS        10        20        30        40        50        60        70        80        90       100       110       120 m276.pepFKMARAMATRCRCPPDKLLPFDPMGWCSPSGELSIRLCRLAVWRANRTSASPASGRLYRT|||||||||||||||||||||||||||||||: ||||||||:|||:|||||||||||||| g276FKMARAMATRCRCPPDKLLPFDPMGWCSPSGDASIRLCRLAAWRADRTSASPASGRLYRT        70        80        90       100       110       120       130       140       150       160       170       180 m276.pepFSNRVSSNRNTSWETRANWARRQSSLMSAMSIPSMQMLPADGSTKRGSRLTTVDLPLPER||||||||||||||||||||||||||||||||||||||||||||||| |||||||||||| g276FSNRVSSNRNTSWETRANWARRQSSLMSAMSIPSMQMLPADGSTKRGRRLTTVDLPLPER       130       140       150       160       170       180       190       200       210       220       230       240 m276.pepPTRATRSPCLMSRLKLSRALMPSERYSTSTLRKLMRPSTRCGASVPLSCSGGVSRNAHTP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g276PTRATRSPCLMSRLKLSRALMPSERYSTSTLRKLMRPSTRCGASVPLSCSGGVSRNAHTP       190       200       210       220       230       240       250       260       270      279 m276.pepSAARNIVCIGMLMLARLLMGAYICSIATMNAINSPMVVX||||||||||||||||||||||||||||||||||||||| g276SAARNIVCIGMLMLARLLMGAYICSIATMNAINSPMVVX        250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1131>:

a276.seq 1 ATGATTTTGC CGTCGTCCAT TACGATGATG CGGTCGGCCC CTTCGATGGT 51GGTCAGGCGG TGGGCGACGA TGATGCCGGT GCGGTTTTCC ATCAGGCGTT 101 CGAGCGCCTGTTGGACGAGG CGTTCGGATT CGTTGTCCAA TGCGCTGGTG 151 GCTTCGTCCA ATAATAATATCGGCGCGTCT TTCAAAATGG CGCGGGCAAT 201 GGCAACGCGT TGCCGCTGTC CGCCGGATAAGTTGCTGCCG TTCGATCCGA 251 TGGGCTGGTG CAGTCCGAGC GGTGATGCGT CGATCAGGCTTTGCAGGTTA 301 GCGGCTTGGA GGGCGGATAG GACTTCGGCT TCGCCCGCGT CGGGACGGCT351 ATATCGGACG TTTTCAAACA GGGTGTCGTC AAACAGGAAT ACGTCTTGGG 401AGACGAGGGC AAATTGGGCG CGCAGGCAGT CGAGTTTGAT GTCGGCGATG 451 TCGATACCGTCTATGCAGAT GTTGCCGGCA GACGGTTCGA CAAAGCGGGG 501 CAGCAGGTTG ACGACGGTGGATTTGCCGCT GCCGGAACGT CCGACCAGGG 551 CGACGCGTTC GCCTTGTCTG ATGTCGAGGTTGAAGCCGTC GAGGGCTTTG 601 ATGCCGTCCG AACGGTATTC GACATCGACG TTGCGGAAGCTGATGCGCCC 651 TTCGACACGC TGCGGTGCGA GCGTGCCTTT GTCCTGTTCG GGCGGGGTGT701 CGAGAAATGC ACATACGCCG TCGGCGGCGA GGAACATCGT CTGCATAGGG 751ATGCTAATGT TGGCAAGGCT TTTGATGGGG GCGTACATTT GCAGCATCGC 801 GACGATGAATGCCATAAATT CGCCGATGGT GGTGTAGThis corresponds to the amino acid sequence <SEQ ID 1132; ORF 276.a>:

a276.pep 1 MILPSSITMM RSAPSMVVRR WATMMPVRFS IRRSSACWTR RSDSLSNALV 51ASSNNNIGAS FKMARAMATR CRCPPDKLLP FDPMGWCSPS GDASIRLCRL 101 AAWRADRTSASPASGRLYRT FSNRVSSNRN TSWETRANWA RRQSSLMSAM 151 SIPSMQMLPA DGSTKRGSRLTTVDLPLPER PTRATRSPCL MSRLKPSRAL 201 MPSERYSTST LRKLMRPSTR CGASVPLSCSGGVSRNAHTP SAARNIVCIG 251 MLMLARLLMG AYICSIATMN AINSPMVV* m276/a27698.2% identity in 278 aa overlap        10        20        30        40        50        60 m276.pepMILPSSITMMRSAPSMVVRRWATMMPVRFSIRRSSACWTRRSDSLSNALVASSNNNIGAS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a276MILPSSITMMRSAPSMVVRRWATMMPVRFSIRRSSACWTRRSDSLSNALVASSNNNIGAS        10        20        30        40        50        60        70        80        90       100       110       120 m276.pepFKMARAMATRCRCPPDKLLPFDPMGWCSPSGELSIRLCRLAVWRANRTSASPASGRLYRT|||||||||||||||||||||||||||||||: ||||||||:|||:|||||||||||||| a276FKMARAMATRCRCPPDKLLPFDPMGWCSPSGDASIRLCRLAAWRADRTSASPASGRLYRT        70        80        90       100       110       120       130       140       150       160       170       180 m276.pepFSNRVSSNRNTSWETRANWARRQSSLMSAMSIPSMQMLPADGSTKRGSRLTTVDLPLPER|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a276FSNRVSSNRNTSWETRANWARRQSSLMSAMSIPSMQMLPADGSTKRGSRLTTVDLPLPER       130       140       150       160       170       180       190       200       210       220       230       240 m276.pepPTRATRSPCLMSRLKLSRALMPSERYSTSTLRKLMRPSTRCGASVPLSCSGGVSRNAHTP||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| a276PTRATRSPCLMSRLKPSRALMPSERYSTSTLRKLMRPSTRCGASVPLSCSGGVSRNAHTP       190       200       210       220       230       240       250       260       270      279 m276.pepSAARNIVCIGMLMLARLLMGAYICSIATMNAINSPMVVX||||||||||||||||||||||||||||||||||||||| a276SAARNIVCIGMLMLARLLMGAYICSIATMNAINSPMVVX        250       260       270The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 1133>:

g277.seq (partial) 1 ..atggtacacg tcgccgtagc ttacggtatt gccgtccggcgtttttgccc 51   aaacgaggtc atagacgttt tccacgcctt gcaggtacat cgccaagcgt101   tcgatgccgt aggtaatttc gccgagtacg ggcgtgcaat cgataccgcc 151  gacttgttgg aaataggtaa actgggttac ttccatgccg ttgagccaga 201  cttcccagcc caaaccccac gcaccgaggg tggggttttc ccagtcgtct 251  tcgacaaagc ggatgtcgtg gactttggga tcgatgccca attcgcgcag 301  ggagtcgaga tagaggtctt ggatattggc gggggcgggt ttgagggcga 351  cttggaattg gtaatagtgt tgcaggcggt tggggttgtc gccgtagcgg 401  ccgtctttgg ggcggcggct gggttggacg taggcggcaa accaaggctc 451  ggggccgagc gcgcgcaggc aggtggcggg atgggatgtg ccggcaccga 501  cttccatgtc gaagggttgg atgacggtgc agcctttgtc tgcccagaag 551  gtttgcagtt tgaagatgat ttgttggaag gtaagcatgg cttattgttc 601  gataaaataa aggttttatt ttactgtttc catagccgct tgaatagatt 651  tatctcgaag acagcctgaThis corresponds to the amino acid sequence <SEQ ID 1134; ORF 277.ng>:

g277.pep (partial) 1 ..MVHVAVAYGI AVRRFCPNEV IDVFHALQVH RQAFDAVGNFAEYGRAIDTA 51   DLLEIGKLGY FHAVEPDFPA QTPRTEGGVF PVVFDKADVV DFGIDAQFAQ101   GVEIEVLDIG GGGFEGDLEL VIVLQAVGVV AVAAVFGAAA GLDVGGKPRL 151  GAERAQAGGG MGCAGTDFHV EGLDDGAAFV CPEGLQFEDD LLEGKHGLLF 201  DKIKVLFYCF HSRLNRFISK TA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1135>:

m277.seq 1 ATGCCCCGCT TTGAGGACAA GCTCGTAGGC AGGCAGGGCG AGGGCGGCGT 51TTTCTTCGGC AAGCAGGCGT TTGGCTTGCG CTTCGTAGTC GTTGAACTGG 101 CGCAGCAGCCAGTCGGCATC GCTGTATTCG AAGTTGTAGG TGGATTGCTC 151 GACTTCGTTT TGGTGGTACACGTCGCCGTA GGTGACGGTG TTGCCGTCGA 201 GCGTTTTTGC CCAAACGAGG TCGTAGACGTTTTCTACACC TTGCAAGTAC 251 ATCGCCAAGC GTTCGATGCC GTAGGTGATT TCGCCGAGTACGGGCGTGCA 301 GTCGATGCCG CCGACTTGTT GGAAATAGGT AAACTGGGTT ACTTCCATGC351 CGTTGAGCCA GACTTCCCAG CCCAAACCCC ACGCGCCGAG GGTGGGGTTT 401TCCCAGTCGT CTTCGACAAA GCGGATGTCG TGGACTTTGG GATCGATGCC 451 CAATTCGCGCAGAGAGTCGA GATAGAGGTC TTGGATATTG GCGGGAGCGG 501 GCTTGAGGGC GACTTGGAATTGGTAATAGT GTTGCAGGCG GTTGGGGTTG 551 TCGCCGTAGC GGCCGTCTTT GGGGCGGCGGCTGGGTTGGA CGTAGGCGGC 601 AAACCAAGGC TCGGGGCCGA GTGCGCGCAG GCAGGTGGCGGGATGGGATG 651 TGCCGGCACC GACTTCCATG TCGAAGGGTT GGATGACGGT GCAGCCTTTG701 TCTGCCCAGA ATGTTTGCAG TTTGAAGATG ATTTGTTGGA AGGTAAGCAT 751 GGCTTATGAThis corresponds to the amino acid sequence <SEQ ID 1136; ORF 277>:

m277.pep 1 MPRFEDKLVG RQGEGGVFFG KQAFGLRFVV VELAQQPVGI AVFEVVGGLL 51DFVLVVHVAV GDGVAVERFC PNEVVDVFYT LQVHRQAFDA VGDFAEYGRA 101 VDAADLLEIGKLGYFHAVEP DFPAQTPRAE GGVFPVVFDK ADVVDFGIDA 151 QFAQRVEIEV LDIGGSGLEGDLELVIVLQA VGVVAVAAVF GAAAGLDVGG 201 KPRLGAECAQ AGGGMGCAGT DFHVEGLDDGAAFVCPECLQ FEDDLLEGKH 251 GL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 277 shows 90.0% identity over a 221 aa overlap with a predicted ORF(ORF 277.ng) from N. gonorrhoeae:

g277/m277                                       10        20        30g277.pep                               MVHVAVAYGIAVRRFCPNEVIDVFHALQVH                              :|||||: |:||:|||||||:|||::|||| m277GLRFVVVELAQQPVGIAVFEVVGGLLDFVLVVHVAVGDGVAVERFCPNEVVDVFYTLQVH    30        40        50        60        70        80        40        50        60        70        80        90 g277.pepRQAFDAVGNFAEYGRAIDTADLLEIGKLGYFHAVEPDFPAQTPRTEGGVFPVVFDKADVV||||||||:|||||||:|:|||||||||||||||||||||||||:||||||||||||||| m277RQAFDAVGDFAEYGRAVDAADLLEIGKLGYFHAVEPDFPAQTPRAEGGVFPVVFDKADVV    90       100       110       120       130       140       100       110       120       130       140       150 g277.pepDFGIDAQFAQGVEIEVLDIGGGGFEGDLELVIVLQAVGVVAVAAVFGAAAGLDVGGKPRL|||||||||| ||||||||||:|:|||||||||||||||||||||||||||||||||||| m277DFGIDAQFAQRVEIEVLDIGGSGLEGDLELVIVLQAVGVVAVAAVFGAAAGLDVGGKPRL   150       160       170       180       190       200       160       170       180       190       200 g277.pepGAERAQAGGGMGCAGTDFHVEGLDDGAAFVCPEGLQFEDDLLEGKHGLL||| ||||||||||||||||||||||||||||| |||||||||||||| m277GAECAQAGGGMGCAGTDFHVEGLDDGAAFVCPECLQFEDDLLEGKHGLX   210       220       230       240       250The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1137>:

a277.seq 1 ATGCCCCGCT TTGAGGACAA GCTCGTAGGC AGGCAGGGCG AGGGCGGCGT 51TTTCTTCGGC AAGCAGGCGT TTGGCTTGCG CTTCGTAGTC GTTGAACTGG 101 CGCAGCAGCCAATCGGCATC GCTGTATTCG AAGTTGTAGG TGGATTGTTC 151 GACTTCGTTT TGGTGGTACACGTCGCCGTA AGTTACTGTA TTACCGTCCA 201 GCGTTTTTGC CCAAACGAGG TCATAGACGTTTTCCACGCC TTGCAGGTAC 251 ATCGCCAAGC GTTCGATGCC GTAGGTGATT TCGCCGAGTACGGGGGTGCA 301 GTCGATGCCG CCGACTTGTT GGAAATAGGT GAACTGGGTT ACTTCCATAC351 CGTTGAGCCA GACTTCCCAG CCCAAACCCC ACGCGCCGAG GGTGGGGTTT 401TCCCAGTCGT CTTCGACAAA GCGGATGTCG TGCACTTTGG GGTCGATGCC 451 CAATTCGCGCAGGGAGTCGA GATAGAGGTC TTGGATATTG GCGGGAGCGG 501 GCTTGAGGGC GACTTGGAATTGGTAATAGT GTTGCAGGCG GTTGGGGTTG 551 TCGCCGTAGC GACCGTCTTT GGGGCGGCGGCTGGGTTGGA CGTAGGCGGC 601 AAACCAAGGC TCGGGGCCGA GTGCGCGCAG ACAGGTGGCGGGATGGGATG 651 TGCCGGCACC GACTTCCATG TCGAAGGGTT GGATGACGGT GCAGCCTTTG701 TCTGCCCAGA ATGTTTGCAG TTTGAAGATG ATTTGTTGGA AGGTAAGCAT 751 GGCTTATGAThis corresponds to the amino acid sequence <SEQ ID 1138; ORF 277.a>:

a277.pep 1 MPRFEDKLVG RQGEGGVFFG KQAFGLRFVV VELAQQPIGI AVFEVVGGLF 51DFVLVVHVAV SYCITVQRFC PNEVIDVFHA LQVHRQAFDA VGDFAEYGGA 101 VDAADLLEIGELGYFHTVEP DFPAQTPRAE GGVFPVVFDK ADVVHFGVDA 151 QFAQGVEIEV LDIGGSGLEGDLELVIVLQA VGVVAVATVF GAAAGLDVGG 201 KPRLGAECAQ TGGGMGCAGT DFHVEGLDDGAAFVCPECLQ FEDDLLEGKH 251 GL* m277/a277 92.5% identity in 252 aa overlap        10        20        30        40        50        60 m277.pepMPRFEDKLVGRQGEGGVFFGKQAFGLRFVVVELAQQPVGIAVFEVVGGLLDFVLVVHVAV|||||||||||||||||||||||||||||||||||||:|||||||||||:|||||||||| a277MPRFEDKLVGRQGEGGVFFGKQAFGLRFVVVELAQQPIGIAVFEVVGGLFDFVLVVHVAV        10        20        30        40        50        60        70        80        90       100       110       120 m277.pepGDGVAVERFCPNEVVDVFYLLQVHRQAFDAVGDFAEYGRAVDAADLLEIGKLGYFHAVEP:  ::|:|||||||:|||::|||||||||||||||||| |||||||||||:|||||:||| a277SYCITVQRFCPNEVIDVFHALQVHRQAFDAVGDFAEYGGAVDAADLLEIGELGYFHTVEP        70        80        90       100       110       120       130       140       150       160       170       180 m277.pepDFPAQTPRAEGGVFPVVFDKADVVDFGIDAQFAQRVEIEVLDIGGSGLEGDLELVIVLQA|||||||||||||||||||||||| ||:|||||| ||||||||||||||||||||||||| a277DFPAQTPRAEGGVFPVVFDKADVVHFGVDAQFAQGVEIEVLDIGGSGLEGDLELVIVLQA       130       140       150       160       170       180       190       200       210       220       230       240 m277.pepVGVVAVAAVFGAAAGLDVGGKPRLGAECAQAGGGMGCAGTDFHVEGLDDGAAFVCPECLQ|||||||:||||||||||||||||||||||:||||||||||||||||||||||||||||| a277VGVVAVATVFGAAAGLDVGGKPRLGAECAQTGGGMGCAGTDFHVEGLDDGAAFVCPECLQ       190       200       210       220       230       240        250m277.pep FEDDLLEGKHGLX ||||||||||||| a277 FEDDLLEGKHGLX        250The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1139>:

g278.seq (partial) 1 ttgcgtgcaa tcacgcccgg tgcgattttt tcgacaggggcggtcaaagt 51 tgtattaatc ggacctttgc cgtcgatagg ccgacccaat gcatcgacga 101cgcgtccgac caattcgcgt ccgaccggca cttctaaaat acggccggta 151 caggtaaccgtgtcgccttc tttaatatgt tcgtactcgc ccaacactac 201 ggcaccgacg gagtcgcgctccaggttcat cgccaagcct aaagtgttac 251 ccgggaattc gagcatctca ccttgcattgcatctgacaa accatggatg 301 cgaacgatac cgtcagttac cgaaatcacc gtaccacgggtactcacttc 351 ggcatttaca gacagatttt cgatcttggc tttaatcaga tcgctaattt401 cagcaggatt aagctgcatg aaaactctcc taattcgtca tagtcgtgta 451caaagcactc agtttgcctt gtacagacaa atccaaaacc tgatcaccca 501 cttcaactttta...This corresponds to the amino acid sequence <SEQ ID 1140; ORF 278.ng>:

g278.pep (partial) 1 LRAITPGAIF STGAVKVVLI GPLPSIGRPN ASTTRPTNSRPTGTSKIRPV 51 QVTVSPSLIC SYSPNTTAPT ESRSRFIAKP KVLPGNSSIS PCIASDKPWM 101RTIPSVTEIT VPRVLTSAFT DRFSILALIR SLISAGLSCM KTLLIRHSRV 151 QSTQFALYRQIQNLITHFNF ....The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1141>:

m278.seq.. 1 TTGCGCGCAA TCACGCCCGG TGCGATTTTT TCGATAGGGG CGGTCAAAGT 51TGTATTAATC GGGCCTTTGC CGTCGATAGG CCGACCCAAT GCATCAACGA 101 CGCGTCCGACCAGTTCGCGT CCGACCGGCA CTTCCAAGAT ACGACCGGTA 151 CAGGTAACCG TGTCGCCTTCTTTAATGTGT TCGTACTCGC CCAACACTAC 201 GGCGCCGACG GAGTCGCGCT CCAGGTTCATCGCCAAGCCG AAAGTGTTAC 251 CCGGGAATTC GAGCATCTCA CCTTGCATTG CATCTGACAAACCATGGATG 301 CGAACGATAC CGTCAGTTAC CGAAATTACC GTACCACAGG TACGCACTTC351 GGCATTTACA GACAGATTTT CGATCTTGGC TTTAATCAAA TCGCTAATTT 401CAGCAGGATT AAGCTGCATG AAAACTCTCC TAATTCGTCA TAGTCGTGTA 451 CAAGGCACTCAATTTGCCTT GTACAGACAA ATCCAAAACC TGATCACCCA 501 CTTCAACTTT TATGCCGCCAATCAGCTCCG GTTCGATTTC GACAGAGATT 551 TTCAGCTCGC TGTCGAAACG CTTATTCAGCATTTGCACCA ACTCGCCGAC 601 CTGTTTGTCG GTCAACGGAT AGGCACTGTA AATGACGGCAGATTTGATAT 651 GGTTGAATGAThis corresponds to the amino acid sequence <SEQ ID 1142; ORF 278>:

m278.pep 1 LRAITPGAIF SIGAVKVVLI GPLPSIGRPN ASTTRPTSSR PTGTSKIRPV 51QVTVSPSLMC SYSPNTTAPT ESRSRFIAKP KVLPGNSSIS PCIASDKPWM 101 RTIPSVTEITVPQVRTSAFT DRFSILALIK SLISAGLSCM KTLLIRHSRV 151 QGTQFALYRQ IQNLITHFNFYAANQLRFDF DRDFQLAVET LIQHLHQLAD 201 LFVGQRIGTV NDGRFDMVE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 278 shows 95.9% identity over a 170 aa overlap with a predicted ORF(ORF 278.ng) from N. gonorrhoeae:

g278/m278         10        20        30        40        50        60g278.pep LRAITPGAIFSTGAVKVVLIGPLPSIGRPNASTTRPTNSRPTGTSKIRPVQVTVSPSLIC||||||||||| |||||||||||||||||||||||||:||||||||||||||||||||:| m278LRAITPGAIFSIGAVKVVLIGPLPSIGRPNASTTRPTSSRPTGTSKIRPVQVTVSPSLMC        10        20        30        40        50        60        70        80        90       100       110       120 g278.pepSYSPNTTAPTESRSRFIAKPKVLPGNSSISPCIASDKPWMRTIPSVTEITVPRVLTSAFT||||||||||||||||||||||||||||||||||||||||||||||||||||:|10 ||||| m278SYSPNTTAPTESRSRFIAKPKVLPGNSSISPCIASDKPWMRTIPSVTEITVPQVRTSAFT        70        80        90       100       110       120       130       140       150       160       170 g278.pepDRFSILALIRSLISAGLSCMKTLLIRHSRVQSTQFALYRQIQNLITHFNF|||||||||:|||||||||||||||||||||:|||||||||||||||||| m278DRFSILALIKSLISAGLSCMKTLLIRHSRVQGTQFALYRQIQNLITHFNFYAANQLRFDF       130       140       150       160       170       180 m278DRDFQLAVETLIQHLHQLADLFVGQRIGTVNDGRFDMVE*        190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1143>:

a278.seq 1 TTGCGCGCAA TCACGCCCGG TGCGATTTTT TCGATAGGGG CGGTCAAAGT 51TGTATTAATC GGGCCTTTGC CGTCGATAGG CCGACCCAAT GCATCAACGA 101 CGCGTCCGACCAGTTCGCGT CCGACCGGCA CTTCCAAGAT ACGACCGGTA 151 CAGGTAACCG TGTCGCCTTCTTTAATATGT TCGTGCTCGC CCAACACTAC 201 GGCGCCGACG GAGTCGCGCT CCAGGTTCATCGCCAAGCCG AAAGTGTTAC 251 CCGGGAATTC GAGCATCTCA CCTTGCATTG CATCTGACAAACCATGGATG 301 CGAACGATAC CGTCAGTTAC CGAAATCACC GTACCACGGG TACGCACTTC351 GGCATTTACA GACAGATTTT CGATCTTGGC TTTAATCAAA TCGCTAATTT 401CAGCAGGATT AAGCTGCATG AAAACTCTCC TAATTCGTCA TAGTCGTGTA 451 CAAGGCACTCAATTTGCCTT GTACAGACAA ATCCAAAACC TGATCACCCA 501 CTTCAACTTT TATGCCGCCAATCAGCTCCG GTTCGATTTC GACAGAGATT 551 TTCAGCTCGC TGTCGAAACG CTTATTCAGCATTTGCGCCA ACTCGCCGAC 601 CTGTTTGTCG GTCAACGGAT AGGCACTGTA AATGACGGCAGATTTGATAT 651 GGTTGAATGAThis corresponds to the amino acid sequence <SEQ ID 1144; ORF 278.a>:

a278.pep 1 LRAITPGAIF SIGAVKVVLI GPLPSIGRPN ASTTRPTSSR PTGTSKIRPV 51QVTVSPSLIC SCSPNTTAPT ESRSRFIAKP KVLPGNSSIS PCIASDKPWM 101 RTIPSVTEITVPRVRTSAFT DRFSILALIK SLISAGLSCM KTLLIRHSRV 151 QGTQFALYRQ IQNLITHFNFYAANQLRFDF DRDFQLAVET LIQHLRQLAD 201 LFVGQRIGTV NDGRFDMVE* m278/a27898.2% identity in 219 aa overlap        10        20        30        40        50        60 m278.pepLRAITPGAIFSIGAVKVVLIGPLPSIGRPNASTTRPTSSRPTGTSKIRPVQVTVSPSLMC||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:| a278LRAITPGAIFSIGAVKVVLIGPLPSIGRPNASTTRPTSSRPTGTSKIRPVQVTVSPSLIC        10        20        30        40        50        60        70        80        90       100       110       120 m278.pepSYSPNTTAPTESRSRFIAKPKVLPGNSSISPCIASDKPWMRTIPSVTEITVPQVRTSAFT| ||||||||||||||||||||||||||||||||||||||||||||||||||:||||||| a278SCSPNTTAPTESRSRFIAKPKVLPGNSSISPCIASDKPWMRTIPSVTEITVPRVRTSAFT        70        80        90       100       110       120       130       140       150       160       170       180 m278.pepDRFSILALIKSLISAGLSCMKTLLIRHSRVQGTQFALYRQIQNLITHFNFYAANQLRFDF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a278DRFSILALIKSLISAGLSCMKTLLIRHSRVQGTQFALYRQIQNLITHFNFYAANQLRFDF       130       140       150       160       170       180       190       200       210       220 m278.pepDRDFQLAVETLIQHLHQLADLFVGQRIGTVNDGRFDMVEX|||||||||||||||:|||||||||||||||||||||||| a278DRDFQLAVETLIQHLRQLADLFVGQRIGTVNDGRFDMVEX       190       200       210       220The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 1145>:

g279.seq 1 atgacgcgga tttgcggctg cttgatttca acggttttga gtgtttcggc 51aagtttgtcg gcggcgggtt tcatcaggct gcaatgggaa ggaacggata 101 ccggcagcggcagggcgcgt ttggctccgg cttctttggc ggcagccatg 151 gtgcgtccga cggcggcggcgttgcctgca atcacgactt gtccgggcga 201 gttgaagttg acggcttcga ccacttcgccctgtgcggat tcggcacaaa 251 tctgcctgac ctgttcatct tccaaaccca aaatggccgccattgcgcct 301 acgccttgcg gtacggcgga ctgcatcagt tcggcgcgca ggcggacgag351 tttgacggca tcggcaaaat ccaatgcttc ggcggcgaca agcgcggtgt 401attcgccgag gctgtgtccg gcaacggcgg caggcgtttt gccgcccact 451 tccaaatagThis corresponds to the amino acid sequence <SEQ ID 1146; ORF 279.ng>:

g279.pep 1 MTRICGCLIS TVLSVSASLS AAGFIRLQWE GTDTGSGRAR LAPASLAAAM 51VRPTAAALPA ITTCPGELKL TASTTSPCAD SAQICLTCSS SKPKMAAIAP 101 TPCGTADCISSARRRTSLTA SAKSNASAAT SAVYSPRLCP ATAAGVLPPT 151 SK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1147>:

m279.seq 1 ATAACGCGGA TTTGCGGCTG CTTGATTTCA ACGGTTTTCA GGGCTTCGGC 51AAGTTTGTCG GCGGCGGGTT TCATCAGGCT GCAATGGGAA GGTACGGACA 101 CGGGCAGCGGCAGGGCGCGT TTGGCACCGG CTTCTTTGGC GGCAGCCATG 151 GCGCGTCCGA CGGCGGCGGCGTTGCCTGCA ATCACGATTT GTCCGGGTGA 201 GTTGAAGTTG ACGGCTTCGA CCACTTCGCTTTGGGCGGCT TCGGCACAAA 251 TGGCTTTAAC CTGCTCATCT TCCAAGCCGA GAATCGCCGCCATTGCGCCC 301 ACGCCTTGCG GTACGGCGGA CTGCATCAGT TCGGCGCGCA GGCGCACGAG351 TTTGACCGCG TCGGCAAAAT TCAATGCGCC GGCGGCAACG AGTGCGGTGT 401ATTCGCCGAG GCTGTGTCCG GCAACGGCGG CAGGCGTTTT GCCGCCCGCT 451 TCTAAATAGThis corresponds to the amino acid sequence <SEQ ID 1148; ORF 279>:

m279.pep 1 ITRICGCLIS TVFRASASLS AAGFIRLQWE GTDTGSGRAR LAPASLAAAM 51ARPTAAALPA ITICPGELKL TASTTSLWAA SAQMALTCSS SKPRIAAIAP 101 TPCGTADCISSARRRTSLTA SAKFNAPAAT SAVYSPRLCP ATAAGVLPPA 151 SK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 279 shows 89.5% identity over a 152 aa overlap with a predicted ORF(ORF 279.ng) from N. gonorrhoeae:

        10        20        30        40        50        60 m279.pepITRICGCLISTVFRASASLSAAGFIRLQWEGTDTGSGRARLAPASLAAAMARPTAAALPA:|||||||||||: :|||||||||||||||||||||||||||||||||||:||||||||| g279MTRICGCLISTVLSVSASLSAAGFIRLQWEGTDTGSGRARLAPASLAAAMVRPTAAALPA        10        20        30        40        50        60        70        80        90       100       110       120 m279.pepITICPGELKLTASTTSLWAASAQMALTCSSSKPRIAAIAPTPCGTADCISSARRRTSLTA|| |||||||||||||  | |||: ||||||||::||||||||||||||||||||||||| g279ITTCPGELKLTASTTSPCADSAQICLTCSSSKPKMAAIAPTPCGTADCISSARRRTSLTA        70        80        90       100       110       120       130       140       150 m279.pepSAKFNAPAATSAVYSPRLCPATAAGVLPPASKX ||| || ||||||||||||||||||||||:||| g279SAKSNASAATSAVYSPRLCPATAAGVLPPTSKX        130       140       150The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1149>:

a279.seq 1 ATGACNCNGA TTTGCGGCTG CTTGATTTCA ACGGTTTNNA GGGCTTCGGC 51GAGTTTGTCG GCGGCGGGTT TCATGAGGCT GCAATGGGAA GGTACNGACA 101 CNGGCAGCGGCAGGGCGCGT TTGGCGCCGG CTTCTTTGGC GGCAAGCATA 151 GCGCGCTCGA CGGCGGCGGCATTGCCTGCA ATCACGACTT GTCCGGGCGA 201 GTTGAAGTTG ACGGCTTCAA CCACTTCATCCTGTGCGGAT TCGGCGCAAA 251 TTTGTTTTAC CTGTTCATCT TCCAAGCCGA GAATCGCCGCCATTGCGCCC 301 ACGCCTTGCG GTACGGCGGA CTGCATCAGT TCGGCGCGCA NGCGCACGAG351 TTTGACCGCG TCGGCAAAAT CCAATGCGCC GGCGGCAACN AGTGCGGTGT 401ATTCGCCGAN GCTGTGTCCG GCAACGGCGG CAGGCGTTTT GCCGCCCGCT 451 TCCGAATAGThis corresponds to the amino acid sequence <SEQ ID 1150; ORF 279.a>:

a279.pep 1 MTXICGCLIS TVXRASASLS AAGFMRLQWE GTDTGSGRAR LAPASLAASI 51ARSTAAALPA ITTCPGELKL TASTTSSCAD SAQICFTCSS SKPRIAAIAP 101 TPCGTADCISSARXRTSLTA SAKSNAPAAT SAVYSPXLCP ATAAGVLPPA 151 SE* m279/a279 88.2%identity in 152 aa overlap        10        20        30        40        50        60 m279.pepITRICGCLISTVFRASASLSAAGFIRLQWEGTDTGSGRARLAPASLAAAMARPTAAALPA:| ||||||||| |||||||||||:|||||||||||||||||||||||::|| ||||||| a279MTXICGCLISTVXRASASLSAAGFMRLQWEGTDTGSGRARLAPASLAASIARSTAAALPA        10        20        30        40        50        60        70        80        90       100       110       120 m279.pepITICPGELKLTASTTSLWAASAQMALTCSSSKPRIAAIAPTPCGTADCISSARRRTSLTA|| |||||||||||||  | |||: :||||||||||||||||||||||||||| |||||| a279ITTCPGELKLTASTTSSCADSAQICFTCSSSKPRIAAIAPTPCGTADCISSARXRTSLTA        70        80        90       100       110       120       130       140       150 m279.pepSAKFNAPAATSAVYSPRLCPATAAGVLPPASKX ||| |||||||||||| ||||||||||||||:| a279SAKSNAPAATSAVYSPXLCPATAAGVLPPASEX        130       140       150

Expression of ORF 279

The primer described in Table 1 for ORF 279 was used to locate and cloneORF 279.

ORF 279 was cloned in pET and pGex vectors and expressed in E. coli asabove-described. The products of protein expression and purificationwere analyzed by SDS-PAGE. FIG. 2A shows the results of affinitypurification and FIG. 2B shows the expression in E. coli. PurifiedGST-fusion protein was used to immunize mice whose sera were used forELISA (positive result), FACS analysis (FIG. 2C), western blot (FIG.2D). These experiments confirm that 279 is a surface-exposed protein andthat it is a useful immunogen. The hydrophilicity plots, antigenicindex, and amphipatic regions of ORF 279 are provided in FIG. 6. TheAMPHI program is used to predict putative T-cell epitopes (Gao et al1989, J. Immunol 143:3007; Roberts et al. 1996, AIDS Res HumanRetroviruses 12:593; Quakyi et al. 1992, Scand J Immunol Suppl 11:9).The nucleic acid sequence of ORF 279 and the amino acid sequence encodedthereby is provided herein.The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1151>:

g280.seq 1 atgaaacacc tcaaacttac ccttattgcc gcattgctgg ccaccgccgc 51aactgccgca ccccttccgg ttgtaaccag tttcagcatt ttaggcgacg 101 tagccaaacaaatcggcggt gagcgcgtag ccgtacaaag cctcgtcgga 151 gccaaccaag atactcatgcctatcacatg accagtggcg acattaaaaa 201 aatccgcagt gcaaaactcg tcctgctcaacggcttggga cttgaagccg 251 ccgacatcca acgcgccgtc aaacagagca aagtatcctatgccgaagcg 301 accaaaggca tccaacccct caaagccgaa gaagaaggcg gacaccatca351 cgaccaccat cacgaccacg atcatgacca cgaaggacac caccacgacc 401acggcgaata tgacccccac gtctggaacg accctgttct tatgtccgac 451 tatgcccaaaacgtcgctga aaccctgata aaggccgatc ccgaaggcaa 501 agtttattat caacaacgcttgggcaacta ccaaatgcag cttaaaaaac 551 tgcacagcga cgcacaagcc gcatttaatgccgtccctgc cgccaaacgc 601 aaagtcctga ccgggcacga cgcattttcc tacatgggcaaccgctacaa 651 catcagcttc atcgccccgc aaggcgtgag cagcgaagcc gagccgtccg701 ccaaacaagt cgccgccatc atccggcaaa tcaaacgcga aggcatcaaa 751gccgtattta ccgaaaatat caaagacacc cgcatggttg accgcatcgc 801 caaagaaaccggcgtcaacg tcagcggcaa actgtattcc gacgcactcg 851 gcaacgcgcc cgcagacacctacatcggca tgtaccgcca caacgtcgaa 901 gccttgacca acgcgatgaa gcaataaThis corresponds to the amino acid sequence <SEQ ID 1152; ORF 280.ng>:

g280.pep 1 MKHLKLTLIA ALLATAATAA PLPVVTSFSI LGDVAKQIGG ERVAVQSLVG 51ANQDTHAYHM TSGDIKKIRS AKLVLLNGLG LEAADIQRAV KQSKVSYAEA 101 TKGIQPLKAEEEGGHHHDHH HDHDHDHEGH HHDHGEYDPH VWNDPVLMSD 151 YAQNVAETLI KADPEGKVYYQQRLGNYQMQ LKKLHSDAQA AFNAVPAAKR 201 KVLTGHDAFS YMGNRYNISF IAPQGVSSEAEPSAKQVAAI IRQIKREGIK 251 AVFTENIKDT RMVDRIAKET GVNVSGKLYS DALGNAPADTYIGMYRHNVE 301 ALTNAMKQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1153>:

m280.seq 1 ATGAAACACC TCAAACTCAC CCTTATTGCC GCATTGCTGA CCGCCTCCGC 51AACTGCCGCC CCCCTGCCGG TTGTAACCAG CTTCAGCATT TTAGGCGACG 101 TAGCCAAACAAATCGGCGGA GAGCGCGTAT CCATACAAAG TTTGGTCGGA 151 GCCAACCAAG ATACGCACGCCTATCATATG ACCAGTGGCG ACATTAAAAA 201 AATCCGCAGT GCAAAACTCG TCCTGCTCAACGGCTTAGGA CTTGAAGCTG 251 CCGATGTGCA ACGCGCCGTC AAACAAAGCA AAGTATCCTATACCGAAGCG 301 ACCAAAGGCA TCCAACCCCT CAAAGCCGAA GAAGAAGGCG GACACCATCA351 CGACCACGAT CATGACCACG AAGGACACCA CCATGACCAC GGCGAATATG 401ACCCGCACGT CTGGAACGAC CCCGTCCTTA TGTCCGCCTA TGCCCAAAAC 451 GTTGCCAAAGCCCTGATAAA GGCCGATCCC GAAGGCAAAG TTTATTATCA 501 ACAACGCTTG GGCAACTACCAAATGCAGCT CAAAAAACTG CACAGCGACG 551 CACAAGCCGC ATTTAATGCC GTCCCTGCTGCCAAACGCAA AGTCCTGACC 601 GGGCACGATG CCTTTTCCTA TATGGGCAAA CGTTACCATATCGAATTCAT 651 CGCCCCGCAA GGCGTGAGCA GCGAAGCCGA GCCTTCGGCC AAACAAGTCG701 CCGCCATCAT CCGACAAATC AAACGCGAAG GCATCAAAGC CGTCTTTACC 751GAAAACATCA AGGACACCCG TATGGTTGAC CGTATCGCCA AAGAAACCGG 801 TGTCAACGTCAGCGGCAAAC TGTATTCCGA CGCACTCGGC AACGCGCCCG 851 CAGACACCTA CATCGGAATGTACCGCCACA ACATCAAAGC CTTGACCAAC 901 GCGATGAAGC AATAAThis corresponds to the amino acid sequence <SEQ ID 1154; ORF 280>:

m280.pep 1 MKHLKLTLIA ALLTASATAA PLPVVTSFSI LGDVAKQIGG ERVSIQSLVG 51ANQDTHAYHM TSGDIKKIRS AKLVLLNGLG LEAADVQRAV KQSKVSYTEA 101 TKGIQPLKAEEEGGHHHDHD HDHEGHHHDH GEYDPHVWND PVLMSAYAQN 151 VAKALIKADP EGKVYYQQRLGNYQMQLKKL HSDAQAAFNA VPAAKRKVLT 201 GHDAFSYMGK RYHIEFIAPQ GVSSEAEPSAKQVAAIIRQI KREGIKAVFT 251 ENIKDTRMVD RIAKETGVNV SGKLYSDALG NAPADTYIGMYRHNIKALTN 301 AMKQ*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 280 shows 93.8% identity over a 308 aa overlap with a predicted ORF(ORF 280.ng) from N. gonorrhoeae:

m280/g280         10        20        30        40        50        60m280.pep MKHLKLTLIAALLTASATAAPLPVVTSFSILGDVAKQIGGERVSIQSLVGANQDTHAYHM|||||||||||||:::|||||||||||||||||||||||||||::||||||||||||||| g280MKHLKLTLIAALLATAATAAPLPVVTSFSILGDVAKQIGGERVAVQSLVGANQDTHAYHM        10        20        30        40        50        60        70        80        90       100       110      119 m280.pepTSGDIKKIRSAKLVLLNGLGLEAADVQRAVKQSKVSYTEATKGIQPLKAEEEGGHHHDH-|||||||||||||||||||||||||:|||||||||||:||||||||||||||||||||| g280TSGDIKKIRSAKLVLLNGLGLEAADIQRAVKQSKVSYAEATKGIQPLKAEEEGGHHHDHH        70        80        90       100       110       120 120       130       140       150       160       170 m280.pep---DHDHEGHHHDHGEYDPHVWNDPVLMSAYAQNVAKALIKADPEGKVYYQQRLGNYQMQ   |||||||||||||||||||||||||| ||||||::|||||||||||||||||||||| g280HDHDHDHEGHHHDHGEYDPHVWNDPVLMSDYAQNVAETLIKADPEGKVYYQQRLGNYQMQ       130       140       150       160       170       180 180       190       200       210       220       230 m280.pepLKKLHSDAQAAFNAVPAAKRKVLTGHDAFSYMGKRYHIEFIAPQGVSSEAEPSAKQVAAI|||||||||||||||||||||||||||||||||:||:| ||||||||||||||||||||| g280LKKLHSDAQAAFNAVPAAKRKVLTGHDAFSYMGNRYNISFIAPQGVSSEAEPSAKQVAAI       190       200       210       220       230       240 240       250       260       270       280       290 m280.pepIRQIKREGIKAVFTENIKDTRMVDRIAKETGVNVSGKLYSDALGNAPADTYIGMYRHNIK||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:: g280IRQIKREGIKAVFTENIKDTRMVDRIAKETGVNVSGKLYSDALGNAPADTYIGMYRHNVE       250       260       270       280       290       300  300m280.pep ALTNAMKQX ||||||||| g280 ALTNAMKQXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1155>:

a280.seq 1 ATGAAACACC CCAAACTCAC CCTTATCGCC GCATTGCTGA CCACTGCCGC 51AACTGCCGCC CCCCTGCCGG TTGTAACCAG CTTCAGCATT TTAGGCGACG 101 TAGCCAAACAAATCGGCGGA GAGCGCGTAT CCATACAAAG TTTGGTCGGA 151 GCCAACCAAG ATACGCACGCCTATCATATG ACCAGCGGCG ACATTAAAAA 201 AATCCGCAGT GCAAAACTCG TCCTGATTAACGGCTTAGGA CTTGAAGCTG 251 CCGACATCCA ACGTGCCGTC AAACAGAGCA AAGTATCCTATGCCGAAGCG 301 ACCAAAGGCA TCCAACCCCT CAAAGCCGAA GAAGAAGGCG GACACCATCA351 CGACCACGAT CATGACCACG ACCATGACCA CGAAGGACAC CACCACGACC 401ACGGCGAATA TGACCCCCAC GTCTGGAACG ACCCCGTCCT TATGTCCGCC 451 TATGCCCAAAACGTCGCCGA AGCCCTGATA AAGGCCGACC CCGAAGGCAA 501 AGTTTATTAT CAACAACGCTTGGGCAACTA CCAAATGCAG CTCAAAAAAC 551 TGCACAGTGA CGCACAAGCC GCATTTAATGCCGTCCCTGC CGCCAAACGC 601 AAAGTCCTGA CCGGGCACGA TGCCTTTTCC TATATGGGCAAACGTTACCA 651 TATCGAATTC ATCGCCCCAC AAGGTGTGAG CAGCGAAGCC GAGCCTTCAG701 CCAAACAAGT CGCCGCCATC ATCCGACAAA TCAAACGCGA AGGCATCAAA 751GCCGTATTTA CCGAAAATAT CAAAGACACC CGCATGGTTG ACCGCATCGC 801 CAAAGAAACCGGTGTCAACG TCAGCGGCAA ACTGTATTCC GACGCACTCG 851 GCAACGCACC CGCAGACACCTACATCGGCA TGTACCGCCA CAACATCAAA 901 GCCTTAACCA ACGCGATGAA GCAATAAThis corresponds to the amino acid sequence <SEQ ID 1156; ORF 280.a>:

a280.pep 1 MKHPKLTLIA ALLTTAATAA PLPVVTSFSI LGDVAKQIGG ERVSIQSLVG 51ANQDTHAYHM TSGDIKKIRS AKLVLINGLG LEAADIQRAV KQSKVSYAEA 101 TKGIQPLKAEEEGGHHHDHD HDHDHDHEGH HHDHGEYDPH VWNDPVLMSA 151 YAQNVAEALI KADPEGKVYYQQRLGNYQMQ LKKLHSDAQA AFNAVPAAKR 201 KVLTGHDAFS YMGKRYHIEF IAPQGVSSEAEPSAKQVAAI IRQIKREGIK 251 AVFTENIKDT RMVDRIAKET GVNVSGKLYS DALGNAPADTYIGMYRHNIK 301 ALTNAMKQ* m280/a280 96.4% identity in 308 aa overlap        10        20        30        40        50        60 m280.pepMKHLKLTLIAALLTASATAAPLPVVTSFSILGDVAKQIGGERVSIQSLVGANQDTHAYHM||| ||||||||||::|||||||||||||||||||||||||||||||||||||||||||| a280MKHPKLTLIAALLTTAATAAPLPVVTSFSILGDVAKQIGGERVSIQSLVGANQDTHAYHM        10        20        30        40        50        60        70        80        90       100       110       120 280.pepTSGDIKKIRSAKLVLLNGLGLEAADVQRAVKQSKVSYTEATKGIQPLKAEEEGGHHHDHD|||||||||||||||:|||||||||:|||||||||||:|||||||||||||||||||||| a280TSGDIKKIRSAKLVLINGLGLEAADIQRAVKQSKVSYAEATKGIQPLKAEEEGGHHHDHD        70        80        90       100       110       120           130       140       150       160       170 m280.pepHDH----EGHHHDHGEYDPHVWNDPVLMSAYAQNVAKALIKADPEGKVYYQQRLGNYQMQ|||    |||||||||||||||||||||||||||||:||||||||||||||||||||||| a280HDHDHDHEGHHHDHGEYDPHVWNDPVLMSAYAQNVAEALIKADPEGKVYYQQRLGNYQMQ       130       140       150       160       170       180 180       190       200       210       220       230 m280.pepLKKLHSDAQAAFNAVPAAKRKVLTGHDAFSYMGKRYHIEFIAPQGVSSEAEPSAKQVAAI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a280LKKLHSDAQAAFNAVPAAKRKVLTGHDAFSYMGKRYHIEFIAPQGVSSEAEPSAKQVAAI       190       200       210       220       230       240 240       250       260       270       280       290 m280.pepIRQIKREGIKAVFTENIKDTRMVDRIAKETGVNVSGKLYSDALGNAPADTYIGMYRHNIK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a280IRQIKREGIKAVFTENIKDTRMVDRIAKETGVNVSGKLYSDALGNAPADTYIGMYRHNIK       250       260       270       280       290       300  300m280.pep ALTNAMKQX ||||||||| a280 ALTNAMKQXThe following partial DNA sequence was identified in N.gonorrhoeae <SEQID 1157>:

g281.seq 1 atgcactacg ccctcgcatc cgtcttctgc ctgtccctca gcgccgcacc 51cgtcggcgta ttcctcgtca tgcgccgtat gagcctgata ggcgacgcat 101 tgagccacgccgtcctgccc ggtgccgccg tcggctacat gtttgccggc 151 ttgagcctgc ccgctatgggtgtgggcggg tttgccgccg gtatgctgat 201 ggcgctgctt gccggactcg tcagccgctttaccaccctg aaagaagatg 251 ccaactttgc cgccttttac ctgagcagcc tcgccatcggcgtaatcctc 301 atcagcaaaa acggcagcag cgtcgattta ctccacctcc ttttcggatc351 tgtgcttgcc gtcgatattc ccgcactgca actcatcgcc gccgtctccg 401gcctcacgct cattaccctt gccgtcatct accgccccct ggtgctagaa 451 agcatagacccccttttcct caagtccgtc aacggcaaag gcgggctttg 501 gcacgtcatt ttcctcatcctcgtcgttat gaacctcgta tccggcttcc 551 aagctctcgg catcctgatg tcggtcggaattatgatgct gcccgccatt 601 accgcccgtt tatgggcaag aaatatgggg acgctcattctgttgtccgt 651 cctcatcgcc cttttttgcg gtttgatcgg gctgctcatt tcctaccaca701 tcgaaatccc ttccggcccc gccatcatcc tctgttgcag cgtcctttat 751cttttttccg tcatactcgg caaagaaggc ggcatcttgc ccaaatggtt 801 caaaaaccaccgccaccaca ccacctgaThis corresponds to the amino acid sequence <SEQ ID 1158; ORF 281.ng>:

g281.pep 1 MHYALASVFC LSLSAAPVGV FLVMRRMSLI GDALSHAVLP GAAVGYMFAG 51LSLPAMGVGG FAAGMLMALL AGLVSRFTTL KEDANFAAFY LSSLAIGVIL 101ISKNGSSVDL LHLLFGSVLA VDIPALQLIA AVSGLTLITL AVIYRPLVLE 151 SIDPLFLKSVNGKGGLWHVI FLILVVMNLV SGFQALGILM SVGIMMLPAI 201 TARLWARNMGTLILLSVLIA LFCGLIGLLI SYHIEIPSGP AIILCCSVLY 251 LFSVILGKEG GILPKWFKNHRHHTT*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1159>:

m281.seq (partial) 1 ATGCGCTACG CCCTCGCATC CGTCTTCTGC CTGTCCCTCAGTGCCGCACC 51 CGTCGGCGTA TTCCTCGTCA TGCGCCGTAT GAGCCTGATA GGCGACGCAT 101TGAGCCACGC CGTCCTGCCC GGTGCCGCCG TCGGCTACAT GTTTGCCGGC 151 TTGAGCCTGCCCGCCATGGG TTTGGGCGGC GTAGCCGCAG GCATGCTGAT 201 GGCACTGCTT GCCGGACTCGTCAGCCGCTT CACCACCCTG AAAGAAGATG 251 CCAACTTTGC CGCCTTTTAT CTCAGCAGCCTCGCCATCGG CGTAGTCCTC 301 GTCAGCAAAA ACGGGAGCAG CGTCGATTTG CTCCACCTCCTTTTCGGCTC 351 TGTACTTGCC GTCGATATTC CTGCCCTGCA GCTCATCGCC GCCGTCTCCA401 GCCTCACGCT CATTACCCTT GCCGTCATCT ACCGCCCGCT CGTACTCGAA 451AGCATCGACC CCCTGTTTCT CAAATCCGTC GGCGGCAAAG GCGGGCTTTG 501 GCACGTCCTCTTTCTCGTCC TGGTCGTCAT GAACCTCGTA TCCGGCTTTC 551 AAGCCCTCGG CACACTCATGTCCGTCGGAC TCATGATGCT GCCAGCCATT 601 ACCGCCCGCC TGTGGGCGAA GCATATGGGCGCACTCATCC TCCTATCCGT 651 TCTGACAGCC CTGCTGTGCG GCTTGAGCGG ACTGCTCATTTCCTACCACA 701 TCGAAATTCC TTCCGGTCCC GCCATCATCC TCTGTTGCAG CGTCCTTTAT751 CTCTTTTCCG TCATACTCGG CAAAGAAGGC GGCATTCTGA CC..This corresponds to the amino acid sequence <SEQ ID 1160; ORF 281>:

m281.pep (partial) 1 MRYALASVFC LSLSAAPVGV FLVMRRMSLI GDALSHAVLPGAAVGYMFAG 51 LSLPAMGLGG VAAGMLMALL AGLVSRFTTL KEDANFAAFY LSSLAIGVVL 101VSKNGSSVDL LHLLFGSVLA VDIPALQLIA AVSSLTLITL AVIYRPLVLE 151 SIDPLFLKSVGGKGGLWHVL FLVLVVMNLV SGFQALGTLM SVGLMMLPAI 201 TARLWAKHMGALILLSVLTA LLCGLSGLLI SYHIEIPSGP AIILCCSVLY 251 LFSVILGKEG GILT..Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 281 shows 93.5% identity over a 263 aa overlap with a predicted ORF(ORF 281.ng) from N. gonorrhoeae:

m281/g281         10        20        30        40        50        60m281.pep MRYALASVFCLSLSAAPVGVFLVMRRMSLIGDALSHAVLPGAAVGYMFAGLSLPAMGLGG|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| g281MHYALASVFCLSLSAAPVGVFLVMRRMSLIGDALSHAVLPGAAVGYMFAGLSLPAMGVGG        10        20        30        40        50        60        70        80        90       100       110       120 m281.pepVAAGMLMALLAGLVSRFTTLKEDANFAAFYLSSLAIGVVLVSKNGSSVDLLHLLFGSVLA |||||||||||||||||||||||||||||||||||||:|:||||||||||||||||||| g281FAAGMLMALLAGLVSRFTTLKEDANFAAFYLSSLAIGVILISKNGSSVDLLHLLFGSVLA        70        80        90       100       110       120       130       140       150       160       170       180 m281.pepVDIPALQLIAAVSSLTLITLAVIYRPLVLESIDPLFLKSVGGKGGLWHVLFLVLVVMNLV|||||||||||||:||||||||||||||||||||||||||:||||||||:||:||||||| g281VDIPALQLIAAVSGLTLITLAVIYRPLVLESIDPLFLKSVNGKGGLWHVIFLILVVMNLV       130       140       150       160       170       180       190       200       210       220       230       240 m281.pepSGFQALGTLMSVGLMMLPAITARLWAKHMGALILLSVLTALLCGLSGLLISYHIEIPSGP||||||| |||||:||||||||||||::||:||||||| ||:||| |||||||||||||| g281SGFQALGILMSVGIMMLPAITARLWARNMGTLILLSVLIALFCGLIGLLISYHIEIPSGP       190       200       210       220       230       240       250       260 m281.pep AIILCCSVLYLFSVILGKEGGILT||||||||||||||||||||||| g281 AIILCCSVLYLFSVILGKEGGILPKWFKNHRHHTTX       250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1161>:

a281.seq 1 ATGCGCTACG CCCTCGCATC CGTCTTCTGC CTGTCCCTCA GTGCCGCACC 51CGTCGGCGTA TTCCTCGTCA TGCGCCGTAT GAGCCTGATA GGCGACGCAT 101 TGAGCCACGCCGTCCTGCCC GGTGCCGCCG TCGGCTACAT GTTTGCCGGC 151 TTAAGCCTGC CCGCCATGGGTTTGGGCGGC GTAGCCGCAG GTATGCTGAT 201 GGCACTGCTT GCCGGACTCG TCAGCCGCTTCACCACCCTG AAAGAAGATG 251 CCAACTTTGC CGCCTTTTAT CTCAGCAGCC TCGCCATCGGTGTAGTCCTC 301 GTCAGCAAAA ACGGCAGCAG CGTCGATTTG CTCCACCTCC TTTTCGGCTC351 CGTACTTGCC GTCGATATTC CTGCCCTGCA ACTCATCGCC GCCGTATCCA 401CCCTCACACT GCTTACCCTT GCCGTCATCT ACCGCCCGCT CGTACTCGAA 451 AGCATCGACCCCCTGTTTCT CAAATCTGTC GGCGGCAAAG GCGGGCTTTG 501 GCACGTCCTC TTTCTCGTCCTGGTCGTCAT GAACCTCGTA TCCGGCTTTC 551 AAGCCCTCGG CACACTCATG TCCGTCGGACTTATGATGCT GCCAGCCATT 601 ACCGCCCGCC TATGGGCGAA GCACATGGGC GCACTCATCCTCCTATCCGT 651 TCTGACAGCC CTGCTGTGCG GCTTGAGCGG ACTGCTCATT TCCTACCACA701 TCGAAATTCC TTCCGGTCCC GCCATCATCC TCTGTTGCAG CGTCCTTTAT 751CTCTTTTCCG TCATACTCGG CAAAGAAGGC GGCATTCTGA CCAAATGGCT 801 CAAAAACCACCGCCACCACA CCACCTGAThis corresponds to the amino acid sequence <SEQ ID 1162; ORF 281.a>:

a281.pep 1 MRYALASVFC LSLSAAPVGV FLVMRRMSLI GDALSHAVLP GAAVGYMFAG 51LSLPAMGLGG VAAGMLMALL AGLVSRFTTL KEDANFAAFY LSSLAIGVVL 101VSKNGSSVDL LHLLFGSVLA VDIPALQLIA AVSTLTLLTL AVIYRPLVLE 151 SIDPLFLKSVGGKGGLWHVL FLVLVVMNLV SGFQALGTLM SVGLMMLPAI 201TARLWAKHMG ALILLSVLTA LLCGLSGLLI SYHIEIPSGP AIILCCSVLY 251 LFSVILGKEGGILTKWLKNH RHHTT* m281/a281 99.2% identity in 264 aa overlap        10        20        30        40        50        60 m281.pepMRYALASVFCLSLSAAPVGVFLVMRRMSLIGDALSHAVLPGAAVGYMFAGLSLPAMGLGG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a281MRYALASVFCLSLSAAPVGVFLVMRRMSLIGDALSHAVLPGAAVGYMFAGLSLPAMGLGG        10        20        30        40        50        60        70        80        90       100       110       120 m281.pepVAAGMLMALLAGLVSRFTTLKEDANFAAFYLSSLAIGVVLVSKNGSSVDLLHLLFGSVLA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a281VAAGMLMALLAGLVSRFTTLKEDANFAAFYLSSLAIGVVLVSKNGSSVDLLHLLFGSVLA        70        80        90       100       110       120       130       140       150       160       170       180 m281.pepVDIPALQLIAAVSSLTLITLAVIYRPLVLESIDPLFLKSVGGKGGLWHVLFLVLVVMNLV|||||||||||||:|||:|||||||||||||||||||||||||||||||||||||||||| a281VDIPALQLIAAVSTLTLLTLAVIYRPLVLESIDPLFLKSVGGKGGLWHVLFLVLVVMNLV       130       140       150       160       170       180       190       200       210       220       230       240 m281.pepSGFQALGTLMSVGLMMLPAITARLWAKHMGALILLSVLTALLCGLSGLLISYHIEIPSGP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a281SGFQALGTLMSVGLMMLPAITARLWAKHMGALILLSVLTALLCGLSGLLISYHIEIPSGP       190       200       210       220       230       240       250       260 m281.pep AIILCCSVLYLFSVILGKEGGILT|||||||||||||||||||||||| a281 AIILCCSVLYLFSVILGKEGGILTKWLKNHRHHTTX       250       260       270The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 1163>:

g282.seq 1 atgggattgg gtatggaaat cggcaagctg attgtggctc ttttggtgct 51gatcaatccg tttagcgcgt tgtcgcttta ccttgacctg accaacggac 101 acagcacgaaggagcgcagg aaggtcgcgc ggacggccgc cgtcgccgtg 151 tttgccgtga ttgcggtatttgcgctgatc ggcggtgcgc tattgaaggt 201 tttgggcatc agcgtcggtt cgtttcaggtcggcggcggg attttggtgc 251 tgctgatcgc catttcgatg atgaacggca acgacaatcccgccaagcag 301 aatctcggcg cgcagccgga aacggggcaa gcgcgccccg cccgcaatgc351 aggggcgatt gccgtcgtgc ccatcgccat accgatcacc atcggtccgg 401gcggtatttc gactgtgatt atttatgctt cggcagccaa aacgtacagc 451 gatatcgcgctgattatcgc ggccggtttg gtggtcagtg cgatttgtta 501 tgccatttta atcgttgccgggaaggtcag ccgcctgctg ggcgcgacgg 551 ggctgacgat tttaaaccgc attatgggtatgatgctggc ggcggtatcg 601 gtggagatta ttgtgtcggg actgaaaacg atattcccgcaactggcagg 651 ttgaThis corresponds to the amino acid sequence <SEQ ID 1164; ORF 282.ng>:

g282.pep 1 MGLGMEIGKL IVALLVLINP FSALSLYLDL TNGHSTKERR KVARTAAVAV 51FAVIAVFALI GGALLKVLGI SVGSFQVGGG ILVLLIAISM MNGNDNPAKQ 101 NLGAQPETGQARPARNAGAI AVVPIAIPIT IGPGGISTVI IYASAAKTYS 151DIALIIAAGL VVSAICYAIL IVAGKVSRLL GATGLTILNR IMGMMLAAVS 201 VEIIVSGLKTIFPQLAG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1165>:

m282.seq 1 ATGGGATTGG GCATGGAAAT CGGCAAGCTG ATTGTGGCTT TTTTGGTGCT 51GATTAATCCG TTTAGCGCGT TGTCGCTTTA CCTTGACCTG ACCAACGGGC 101 ACAGCACGAAGGAGCGCAGG AAGGTCGCGC GGACGGCCGC CGTTGCCGTG 151 TTTGCCGTGA TTGCGGTATTTGCGCTGATC GGCGGTACGC TGCTGAAGGT 201 TTTGGGCATC AGCGTCGGTT CGTTTCAGGTCGGCGGCGGG ATTTTGGTGC 251 TGCTGATCGC CATTTCGATG ATGAACGGCA ACGACAATCCCGCCAAGCAG 301 AATCTCGGCG CGCAGCCGGA AACGGGGCAG GCGCGCCCCG CCCGCAATGC351 CGGAGCGATT GCCGTCGTGC CCATCGCCAT ACCGATCACC ATCGGCCCGG 401GCGGTATTTC GACCGTGATT ATTTACGCTT CGGCGGCTAA AACATACGGC 451 GACATCGCGTTGATTATCGC GGCCGGTTTG GTGGTCAGTG CGATTTGTTA 501 TGCCATTTTA ATCGTTGCCGGGAAGGTCAG CCGCCTGCTG GGCGCGACGG 551 GGCTGACGAT TTTAAACCGC ATTATGGGTATGATGCTGGC GGCGGTATCG 601 GTGGAGATTA TTGTGTCGGG ACTGAAAACG ATATTCCCGCAACTGGCAGG 651 TTGAThis corresponds to the amino acid sequence <SEQ ID 1166; ORF 282.ng>:

m282.pep 1 MGLGMEIGKL IVAFLVLINP FSALSLYLDL TNGHSTKERR KVARTAAVAV 51FAVIAVFALI GGTLLKVLGI SVGSFQVGGG ILVLLIAISM MNGNDNPAKQ 101 NLGAQPETGQARPARNAGAI AVVPIAIPIT IGPGGISTVI IYASAAKTYG 151DIALIIAAGL VVSAICYAIL IVAGKVSRLL GATGLTILNR IMGMMLAAVS 201 VEIIVSGLKTIFPQLAG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 282 shows 98.6% identity over a 217 aa overlap with a predicted ORF(ORF 282.ng) from N. gonorrhoeae:

m282/g282         10        20        30        40        50        60m282.pep MGLGMEIGKLIVAFLVLINPFSALSLYLDLTNGHSTKERRKVARTAAVAVFAVIAVFALI|||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||| g282MGLGMEIGKLIVALLVLINPFSALSLYLDLTNGHSTKERRKVARTAAVAVFAVIAVFALI        10        20        30        40        50        60        70        80        90       100       110       120 m282.pepGGTLLKVLGISVGSFQVGGGILVLLIAISMMNGNDNPAKQNLGAQPETGQARPARNAGAI||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g282GGALLKVLGISVGSFQVGGGILVLLIAISMMNGNDNPAKQNLGAQPETGQARPARNAGAI        70        80        90       100       110       120       130       140       150       160       170       180 m282.pepAVVPIAIPITIGPGGISTVIIYASAAKTYGDIALIIAAGLVVSAICYAILIVAGKVSRLL|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| g282AVVPIAIPITIGPGGISTVIIYASAAKTYSDIALIIAAGLVVSAICYAILIVAGKVSRLL       130       140       150       160       170       180       190       200       210 m282.pepGATGLTILNRIMGMMLAAVSVEIIVSGLKTIFPQLAGX|||||||||||||||||||||||||||||||||||||| g282GATGLTILNRIMGMMLAAVSVEIIVSGLKTIFPQLAGX        190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1167>:

a282.seq 1 ATGGGATTGG GCATGGAAAT CGGCAAGCTG ATTGTGGCTT TTTTGGTGCT 51GATTAATCCG TTTAGCGCGT TGTCGCTTTA CCTTGACCTG ACCAACGGGC 101 ACAGCACGAAGGAGCGCAGG AAGGTCGCGC GGACGGCCGC CGTTGCCGTG 151 TTTGCCGTGA TTGCGGTATTTGCGCTGATC GGCGGTACGC TGCTGAAGGT 201 TTTGGGCATC AGCGTCGGTT CGTTTCAGGTCGGCGGCGGA ATTTTGGTGT 251 TGCTGATTGC CATTTCGATG ATGAACGGCA ACGACAATCCCGCCAAGCAG 301 AATCTCGGCG CGCAGCCGGA AACGGGGCAG GTGCGCCCCG CCCGCAATGC351 CGGAGCGATT GCCGTCGTGC CCATCGCCAT ACCGATCACC ATCGGCCCGG 401GCGGTATTTC GACCGTGATT ATTTACGCTT CGGCGGCTAA AACATACGGC 451 GACATCGCGTTGATTATCGC GGCCGGTTTG GTGGTCAGTG CGATTTGTTA 501 TGCCATTTTA ATCGTTGCCGGGAAGGTCAG CCGCCTGCTG GGTGCGACGG 551 GGCTGACGAT TTTAAACCGT ATCATGGGTATGATGCTGGC GGCGGTATCG 601 GTGGAGATTA TTGTGTCGGG ACTGAAAATG ATATTCCCGCAACTGGCAGG 651 TTGAThis corresponds to the amino acid sequence <SEQ ID 1168; ORF 282.a>:

a282.pep 1 MGLGMEIGKL IVAFLVLINP FSALSLYLDL TNGHSTKERR KVARTAAVAV 51FAVIAVFALI GGTLLKVLGI SVGSFQVGGG ILVLLIAISM MNGNDNPAKQ 101 NLGAQPETGQVRPARNAGAI AVVPIAIPIT IGPGGISTVI IYASAAKTYG 151DIALIIAAGL VVSAICYAIL IVAGKVSRLL GATGLTILNR IMGMMLAAVS 201 VEIIVSGLKMIFPQLAG* m282/a282 99.1% identity in 217 aa overlap        10        20        30        40        50        60 m282.pepMGLGMEIGKLIVAFLVLINPFSALSLYLDLTNGHSTKERRKVARTAAVAVFAVIAVFALI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a282MGLGMEIGKLIVAFLVLINPFSALSLYLDLTNGHSTKERRKVARTAAVAVFAVIAVFALI        10        20        30        40        50        60        70        80        90       100       110       120 m282.pepGGTLLKVLGISVGSFQVGGGILVLLIAISMMNGNDNPAKQNLGAQPETGQARPARNAGAI||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| a282GGTLLKVLGISVGSFQVGGGILVLLIAISMMNGNDNPAKQNLGAQPETGQVRPARNAGAI        70        80        90       100       110       120       130       140       150       160       170       180 m282.pepAVVPIAIPITIGPGGISTVIIYASAAKTYGDIALIIAAGLVVSAICYAILIVAGKVSRLL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a282AVVPIAIPITIGPGGISTVIIYASAAKTYGDIALIIAAGLVVSAICYAILIVAGKVSRLL       130       140       150       160       170       180       190       200       210 m282.pepGATGLTILNRIMGMMLAAVSVEIIVSGLKTIFPQLAGX||||||||||||||||||||||||||||| |||||||| a282GATGLTILNRIMGMMLAAVSVEIIVSGLKMIFPQLAGX        190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1169>:

g283.seq 1 atgaactttg ctttatccgt catcacattt accctcgcct ctttcctgcc 51cgtcccgcct gccggaaccg ccgtctttac ttggaaagac ggcggcggca 101 acagctattcggatgtgccg aaacagcttc atcccgacca gagccaaatc 151 ctcaacctgc ggacgctccaaaccaaaccg gcggtcaagc ccaaacctgc 201 cgtcgatacg aatgcggaca gtgcgaaggaaaacgaaaag gatatcgccg 251 agaaaaacgg gcagcttgag gaagaaaaga aaaaaattgccgaaaccgaa 301 cggcagaaca aagaagaaaa ctgccggatt tcaaaaatga acctgaaggc351 ggtgggaaac tcaaatgcga aaaacaagga tgatttgatc cgtaaataca 401ataacgccgt aaacaaatac tgccgttaaThis corresponds to the amino acid sequence <SEQ ID 1170; ORF 283.ng>:

g283.pep 1 MNFALSVITF TLASFLPVPP AGTAVFTWKD GGGNSYSDVP KQLHPDQSQI 51LNLRTLQTKP AVKPKPAVDT NADSAKENEK DIAEKNGQLE EEKKKIAETE 101 RQNKEENCRISKMNLKAVGN SNAKNKDDLI RKYNNAVNKY CR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1171>:

m283.seq 1 ATGAACTTTG CTTTATCCGT CATTATGTTG ACCCTCGCCT CTTTCCTGCC 51CGTCCCGCCT GCCGGAGCCG CCGTCTTTAC TTGGAAGGAC GGCGGCGGCA 101 ACAGCTATTCGGATGTACCG AAACAGCTTC ATCCCGACCA AAGCCAAATC 151 TTAAACCTGC GGACGCGCCAAACCAAACCG GCGGTCAAAC CCGCCCAAGC 201 CGACGCAGGG AAGCGCACAG ACGGCGCGGCACAGGAAAAC AATCCCGACA 251 CTGCCGAGAA AAACCGGCAG CTTGAGGAAG AAAAGAAAAGAATTGCCGAA 301 ACCGAACGGC AGAACAAAGA AGAAAACTGC CGGATTTCAA AAATGAACCT351 GAAGGCGGTG GGAAATTCAA ATGCAAAAAA CAAGGATGAT TTGATTCGGA 401AATACAATAA CGCCGTAAAC AAATACTGCC GTTAAThis corresponds to the amino acid sequence <SEQ ID 1172; ORF 283>:

m283.pep 1 MNFALSVIML TLASFLPVPP AGAAVFTWKD GGGNSYSDVP KQLHPDQSQI 51LNLRTRQTKP AVKPAQADAG KRTDGAAQEN NPDTAEKNRQ LEEEKKRIAE 101 TERQNKEENCRISKMNLKAV GNSNAKNKDD LIRKYNNAVN KYCR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m283/g283 86.1% identity in 144 aa overlap         10        20        30        40        50        60 m283.pep MNFALSVIMLTLASFLPVPPAGAAVFTWKDGGGNSYSDVPKQLHPDQSQILNLRTRQTKP |||||||| :||||||||||||:|||||||||||||||||||||||||||||||| |||| g283 MNFALSVITFTLASFLPVPPAGTAVFTWKDGGGNSYSDVPKQLHPDQSQILNLRTLQTKP         10        20        30        40        50        60         70        80         90       100       110       120 m283.pep AVKPAQADAGKRTDGAAQENNPDTAEKNRQLEEEKKRIAETERQNKEENCRISKMNLKAV  ||||  | :   :| :|:||: | |||| |||||||:||||||||||||||||||||||| g283 AVKPKPA-VDTNAD-SAKENEKDIAEKNGQLEEEKKKIAETERQNKEENCRISKMNLKAV          70         80        90       100       110        130       140 m283.pep  GNSNAKNKDDLIRKYNNAVNKYCRX ||||||||||||||||||||||||| g283  GNSNAKNKDDLIRKYNNAVNKYCRX120       130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1173>:

a283.seq 1 ATGAACTTTG CTTTATCCGT CATTATGTTG ACCCTCGCCT CTTTCCTGCC 51CGTCCCGCCT GCCGGAGCCG CCGTCTTTAC TTGGAAGGAC GGCGGCGGCA 101 ACAGCTATTCGGATGTACCG AAACAGCTTC ATCCCGACCA AAGCCAAATC 151 TTAAACCTGC GGACGCGCCAAACCAAACCG GCGGTCAAAC CCGCCCAAGC 201 CGACGCAGGG AAGCGCACAG ACGGCGCGGCACAGGAAAAC AATCCCGACA 251 CTGCCGAGAA AAACCGGCAG CTTGAGGAAG AAAAGAAAAGAATTGCCGAA 301 ACCGAACGGC AGAACAAAGA AGAAAACTGC CGGATTTCAA AAATGAACCT351 GAAAGCGGTG GGAAATTCAA ATGCAAAAAA CAAGGATGAT TTGATTCGGA 401AATACAATAA CGCCGTAAAC AAATACTGCC GTTAAThis corresponds to the amino acid sequence <SEQ ID 1174; ORF 283.a>:

a283.pep 1 MNFALSVIML TLASFLPVPP AGAAVFTWKD GGGNSYSDVP KQLHPDQSQI 51LNLRTRQTKP AVKPAQADAG KRTDGAAQEN NPDTAEKNRQ LEEEKKRIAE 101 TERQNKEENCRISKMNLKAV GNSNAKNKDD LIRKYNNAVN KYCR* m283/a283 100.0% identity in 144aa overlap         10        20        30        40        50        60m283.pep MNFALSVIMLTLASFLPVPPAGAAVFTWKDGGGNSYSDVPKQLHPDQSQILNLRTRQTKP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a283MNFALSVIMLTLASFLPVPPAGAAVFTWKDGGGNSYSDVPKQLHPDQSQILNLRTRQTKP        10        20        30        40        50        60        70        80        90       100       110       120 m283.pepAVKPAQADAGKRTDGAAQENNPDTAEKNRQLEEEKKRIAETERQNKEENCRISKMNLKAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a283AVKPAQADAGKRTDGAAQENNPDTAEKNRQLEEEKKRIAETERQNKEENCRISKMNLKAV        70        80        90       100       110       120       130       140 m283.pep GNSNAKNKDDLIRKYNNAVNKYCRX||||||||||||||||||||||||| a283 GNSNAKNKDDLIRKYNNAVNKYCRX       130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1175>:

g284.seq. 1 atgccgtctg aaactcgaaa tcggtttcag acggcattgg tttacgcggc 51aggttggggc ttagcggtct ttgtaacggc attcgctttt gcctgcaaaa 101 gagtcgccggctttgcgttt gcctttgaag ccttcgccgg tttttttgaa 151 actgtctttc ttaaagccttctttcttgaa accttcgccg cgcgttttgc 201 cgccgaagcc ttctttgccc ggtttatgatcgccgcgccg gccgccggat 251 ttcctatcgc cccagccgcc tttgcctttc ggcttgccgcctgcggattt 301 gcgtttgcgg gccggctcca tgccttcgat ggtcagttcg ggcagtttgc351 ggttaatgta tttttcgatt ttgtggactt tgacgtattc gttcacttcg 401gcaaacgtaa tcgcaatacc cgtgcggcct gcgcggccgg tgcgcccgat 451 gcggtggacgtagtcttccg cctgtttcgg caggtcgtag tttatgacgt 501 gggtaatggt cggtacgtcaataccgcgtg cggcaacgtc ggtggcaacc 551 aaaattttgc agcggccttt acgcaaatccgtcagcgtgc ggttgcgcca 601 gccctgcggc atatcgccgt gcaggcagtt ggcggcgaaacctttttcgt 651 acaattcatc cgcgatgact tcggtcatcg ctttggtgga cgtgaaaatc701 acacattggt cgatgttggc atcgcgcagg atgtggtcga gcaggcggtt 751tttgtggcgc atatcgtcgc agtacaacaa ctgctcttcg attttgcctt 801 ggccgtccacgcgttcgact tcgataattt cagagtcttt ggtcagtttg 851 cgcgccagtt tgccgactgcgccgtcccaa gtggcggaga acaataaThis corresponds to the amino acid sequence <SEQ ID 1176; ORF 284.ng>:

g284.pep 1 MPSETRNRFQ TALVYAAGWG LAVFVTAFAF ACKRVAGFAF AFEAFAGFFE 51TVFLKAFFLE TFAARFAAEA FFARFMIAAP AAGFPIAPAA FAFRLAACGF 101 AFAGRLHAFDGQFGQFAVNV FFDFVDFDVF VHFGKRNRNT RAACAAGAPD 151 AVDVVFRLFR QVVVYDVGNGRYVNTACGNV GGNQNFAAAF TQIRQRAVAP 201 ALRHIAVQAV GGETFFVQFI RDDFGHRFGGRENHTLVDVG IAQDVVEQAV 251 FVAHIVAVQQ LLFDFALAVH AFDFDNFRVF GQFARQFADCAVPSGGEQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1177>:

m284.seq.. 1 ATGCCGTCTG AAACTCGAAA TCGGTTTCAG ACGGCATTGG TTTATGCGGC 51AGGTTGGGGC TTAGCGGTCT TTGTAACGGC GTTCGCCTTT GCCTGCAAAA 101 GAATCGCCGGCTTTGCGTTT GCCTTTGAAG CCTTCGCCGG TTTTTTTGAA 151 ACCGTCTCTC TTAAAGCCTTCTTTCTTGAA ACCTTCGCCG CGCGTTTTGC 201 CGCCGAAGCC TTCTTTGCTC GGTTTATGATCGCCGCGCCA ACCGCCGGAT 251 TTACGATCGC CCCAGCCGCC TTTGCCTTTC GGCTTGCCGCCTGCGGATTT 301 GCGTTTGCGG GTCGGTTCCA TGCCTTCGAT GGTCAGTTCG GGCAGTTTTC351 GGTTAATGTA TTTTTCGATT TTGTGGACTT TGACGTATTC GTTCACTTCG 401GCAAACGTAA TCGCAATACC CGTGCGGCCT GCGCGGCCGG TGCGCCCGAT 451 GCGGTGGACGTAGTCTTCCG CCTGTTTCGG CAGGTCGTAG TTGATAACGT 501 GGGTAATGGT CGGTACGTCGATACCGCGTG CGGCAACATC GGTGGCAACC 551 AAAATTTTGC AGCGGCCTTT ACGCAAATCCATCAGCGTGC GGTTGCGCCA 601 GCCTTGCGGC ATATCGCCGT GCAGGCAGTT TGCGGCGAAACCTTTTTCGT 651 ACAGTTCATC CGCAATGACT TCGGTCATGG CTTTGGTGGA CGTGAAAATC701 ACGCATTGAT CGATATTGGC ATCGCGCAAG ATATGATCGA GCAGGCGGTT 751TTTGTGGCGC ATATCGTCGC AGTACAGCAG TTGTTCTTCG ATTTTGCCTT 801 GATCGTCCACGCGTTCGACT TCGATGATTT CAGGGTCTTT GGTCAGTTTG 851 CGCGCCAGTT TGCCGACCGCGCCGTCCCAA GTGGCGGAGA ACAACAAAGT 901 CTGACGGTCG CTCGGCGTTG CTTCCACGATGGTTTCGATG TCGTCGATAA 951 AGCCCATATC CAACATACGG TCGGCTTCGT CCAAAATCAGCACTTCCAAA 1001 CGTTCAAAAT CAACTTTGCC GCTTTGCATC AGGTCCATCA GACGGCCCGG1051 CGTGGCGACA ATCAGATCGA CCGGTTTGCT CAGGGCACGG GTTTGGTAGC 1101CGAAAGACGC GCCGCCGACG ATGCTGACGG TGCGGAACCA ACGCATATTT 1151 TTGGCATACGCCAGCGCGTT TTTCTCGACT TGAGCCGCCA GTTCGCGGGT 1201 CGGGGTCAAC ACCAAAGCACGCGGGCCTTT GCCCGGTTTT TCGCTGCGTT 1251 TGGTCAGTTT TTGCAAAGTC GGTAAThis corresponds to the amino acid sequence <SEQ ID 1178; ORF 284>:

m284.pep 1 MPSETRNRFQ TALVYAAGWG LAVFVTAFAF ACKRIAGFAF AFEAFAGFFE 51TVSLKAFFLE TFAARFAAEA FFARFMIAAP TAGFTIAPAA FAFRLAACGF 101 AFAGRFHAFDGQFGQFSVNV FFDFVDFDVF VHFGKRNRNT RAACAAGAPD 151 AVDVVFRLFR QVVVDNVGNGRYVDTACGNI GGNQNFAAAF TQIHQRAVAP 201 ALRHIAVQAV CGETFFVQFI RNDFGHGFGGRENHALIDIG IAQDMIEQAV 251 FVAHIVAVQQ LFFDFALIVH AFDFDDFRVF GQFARQFADRAVPSGGEQQS 301 LTVARRCFHD GFDVVDKAHI QHTVGFVQNQ HFQTFKINFA ALHQVHQTAR351 RGDNQIDRFA QGTGLVAERR AADDADGAEP THIFGIRQRV FLDLSRQFAG 401RGQHQSTRAF ARFFAAFGQF LQSR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m284/g284 92.3% identity in 298 aa overlap        10        20        30        40        50        60 m284.pepMPSETRNRFQTALVYAAGWGLAVFVTAFAFACKRIAGFAFAFEAFAGFFETVSLKAFFLE||||||||||||||||||||||||||||||||||:||||||||||||||||| ||||||| g284MPSETRNRFQTALVYAAGWGLAVFVTAFAFACKRVAGFAFAFEAFAGFFETVFLKAFFLE        10        20        30        40        50        60        70        80        90       100       110       120 m284.pepTFAARFAAEAFFARFMIAAPTAGFTIAPAAFAFRLAACGFAFAGRFHAFDGQFGQFSVNV||||||||||||||||||||:||| ||||||||||||||||||||:||||||||||:||| g284TFAARFAAEAFFARFMIAAPAAGFPIAPAAFAFRLAACGFAFAGRLHAFDGQFGQFAVNV        70        80        90       100       110       120       130       140       150       160       170       180 m284.pepFFDFVDFDVFVHFGKRNRNTRAACAAGAPDAVDVVFRLFRQVVVDNVGNGRYVDTACGNI|||||||||||||||||||||||||||||||||||||||||||| :|||||||:|||||: g284FFDFVDFDVFVHFGKRNRNTRAACAAGAPDAVDVVFRLFRQVVVYDVGNGRYVNTACGNV       130       140       150       160       170       180       190       200       210       220       230       240 m284.pepGGNQNFAAAFTQIHQRAVAPALRHIAVQAVCGETFFVQFIRNDFGHGFGGRENHALIDIG|||||||||||||:|||||||||||||||| ||||||||||:|||| |||||||:|:|:| g284GGNQNFAAAFTQIRQRAVAPALRHIAVQAVGGETFFVQFIRDDFGHRFGGRENHTLVDVG       190       200       210       220       230       240       250       260       270       280       290       300 m284.pepIAQDMIEQAVFVAHIVAVQQLFFDFALIVHAFDFDDFRVFGQFARQFADRAVPSGGEQQS||||::|||||||||||||||:||||| |||||||:||||||||||||| |||||||| g284IAQDVVEQAVFVAHIVAVQQLLFDFALAVHAFDFDNFRVFGQFARQFADCAVPSGGEQX       250       260       270       280       290       310       320       330       340       350       360 m284.pepLTVARRCFHDGFDVVDKAHIQHTVGFVQNQHFQTFKINFAALHQVHQTARRGDNQIDRFAThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1179>:

a284.seq 1 ATGCCGTCTG AAACTCGAAA TCGGTTTCAG ACGGCATTGG TTTATGCGGC 51AGGTTGGGGC TTAGCGGTCT TTGTAACGGC GTTCGCCTTT GCCTGCAAAA 101 GAATCGCCGGCTTTGCGTTT GCCTTTGAAG CCTTCGCCGG TTTTTTTGAA 151 ACCGTCTCTC TTAAAGCCTTCTTTCTTGAA ACCTTCGCCG CGCGTTTTGC 201 CGCCGAAGCC TTCTTTGCTC GGTTTATGATCGCCGCGCCA ACCGCCGGAT 251 TTACGATCGC CCCAGCCGCC TTTGCCTTTC GGCTTGCCGCCTGCGGATTT 301 GCGTTTGCGG GTCGGTTCCA TGCCTTCGAT GGTCAGTTCG GGCAGTTTTC351 GGTTAATGTA TTTTTCGATT TTGTGGACTT TGACGTATTC GTTCACTTCG 401GCAAACGTAA TCGCAATACC CGTGCGGCCT GCGCGGCCGG TGCGCCCGAT 451 GCGGTGGACGTAGTCTTCCG CCTGTTTCGG CAGGTCGTAG TTGATAACGT 501 GGGTAATGGT CGGTACGTCGATACCGCGTG CGGCAACGTC GGTGGCAACC 551 AAAATTTTGC AGCGGCCTTT GCGCAAATCCATCAGCGTGC GGTTGCGCCA 601 GCCTTGCGGC ATATCGCCGT GCAGGCAGTT GGCGGCGAAACCTTTTTCGT 651 ACAATTCATC CGCGATGACT TCGGTCATGG CTTTGGTGGA CGTGAAAATC701 ACGCATTGAT CGATGTCGGC ATCGCGCAAG ATATGATCGA GCAGGCGGTT 751TTTGTGGCGC ATATCGTCGC AGTACAGCAG TTGTTCTTCG ATTTTGCCTT 801 GGTCGTCCACGCGTTCGACT TCGATGATTT CAGGGTCTTT GGTCAGTTTG 851 CGCGCCAGTT TGCCGACCGCGCCGTCCCAA GTGGCGGAGA ACAACAAAGT 901 CTGACGGTCT TCCGGCGTGG CTTCGACGATGGTTTCGATG TCGTCGATAA 951 AGCCCATATC CAACATACGG TCGGCTTCGT CCAAAATCAGCACTTCCAAG 1001 CGGGCGAAAT CGACTTTGCC GCTTTGCATC AAGTCCATCA GACGGCCCGG1051 CGTGGCGACA ATCAGATCGA CCGGTTTGCT CAGGGCGCGG GTTTGGTAGC 1101CGAACGATGC ACCACCGACG ATGCTGACGG TACGGAACCA ACGCATATTT 1151 TTGGCATACGCCAGCGCGTT TTTCTCGACT TGAGCCGCCA ATTCGCGGGT 1201 CGGCGTCAAC ACCAACGCGCGCGGGCCTTT GCCCGGTTTT TCGCTGCGTT 1251 TGGTCAGTCG CTGCAAAGTC GGTAAThis corresponds to the amino acid sequence <SEQ ID 1180; ORF 284.a>:

a284.pep 1 MPSETRNRFQ TALVYAAGWG LAVFVTAFAF ACKRIAGFAF AFEAFAGFFE 51TVSLKAFFLE TFAARFAAEA FFARFMIAAP TAGFTIAPAA FAFRLAACGF 101 AFAGRFHAFDGQFGQFSVNV FFDFVDFDVF VHFGKRNRNT RAACAAGAPD 151 AVDVVFRLFR QVVVDNVGNGRYVDTACGNV GGNQNFAAAF AQIHQRAVAP 201 ALRHIAVQAV GGETFFVQFI RDDFGHGFGGRENHALIDVG IAQDMIEQAV 251 FVAHIVAVQQ LFFDFALVVH AFDFDDFRVF GQFARQFADRAVPSGGEQQS 301 LTVFRRGFDD GFDVVDKAHI QHTVGFVQNQ HFQAGEIDFA ALHQVHQTAR351 RGDNQIDRFA QGAGLVAERC TTDDADGTEP THIFGIRQRV FLDLSRQFAG 401RRQHQRARAF ARFFAAFGQS LQSR* m284/a284 94.8% identity in 424 aa overlap        10        20        30        40        50        60 m284.pepMPSETRNRFQTALVYAAGWGLAVFVTAFAFACKRIAGFAFAFEAFAGFFETVSLKAFFLE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a284MPSETRNRFQTALVYAAGWGLAVFVTAFAFACKRIAGFAFAFEAFAGFFETVSLKAFFLE        10        20        30        40        50        60        70        80        90       100       110       120 m284.pepTFAARFAAEAFFARFMIAAPTAGFTIAPAAFAFRLAACGFAFAGRFHAFDGQFGQFSVNV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a284TFAARFAAEAFFARFMIAAPTAGFTIAPAAFAFRLAACGFAFAGRFHAFDGQFGQFSVNV        70        80        90       100       110       120       130       140       150       160       170       180 m284.pepFFDFVDFDVFVHFGKRNRNTRAACAAGAPDAVDVVFRLFRQVVVDNVGNGRYVDTACGNI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: a284FFDFVDFDVFVHFGKRNRNTRAACAAGAPDAVDVVFRLFRQVVVDNVGNGRYVDTACGNV       130       140       150       160       170       180       190       200       210       220       230       240 m284.pepGGNQNFAAAFTQIHQRAVAPALRHIAVQAVCGETFFVQFIRNDFGHGFGGRENHALIDIG||||||||||:||||||||||||||||||| ||||||||||:||||||||||||||||:| a284GGNQNFAAAFAQIHQRAVAPALRHIAVQAVGGETFFVQFIRDDFGHGFGGRENHALIDVG       190       200       210       220       230       240       250       260       270       280       290       300 m284.pepIAQDMIEQAVFVAHIVAVQQLFFDFALIVHAFDFDDFRVFGQFARQFADRAVPSGGEQQS|||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||| a284IAQDMIEQAVFVAHIVAVQQLFFDFALVVHAFDFDDFRVFGQFARQFADRAVPSGGEQQS       250       260       270       280       290       300       310       320       330       340       350       360 m284.pepLTVARRCFHDGFDVVDKAHIQHTVGFVQNQHFQTFKINFAALHQVHQTARRGDNQIDRFA||| || | ||||||||||||||||||||||||: :|:|||||||||||||||||||||| a284LTVFRRGFDDGFDVVDKAHIQHTVGFVQNQHFQAGEIDFAALHQVHQTARRGDNQIDRFA       310       320       330       340       350       360       370       380       390       400       410       420 m284.pepQGTGLVAERRAADDADGAEPTHIFGIRQRVFLDLSRQFAGRGQHQSTRAFARFFAAFGQF||:|||||| ::|||||:||||||||||||||||||||||| ||| :|||||||||||| a284QGAGLVAERCTTDDADGTEPTHIFGIRQRVFLDLSRQFAGRRQHQRARAFARFFAAFGQS       370       380       390       400       410       420 m284.pepLQSRX ||||| a284 LQSRXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1181>:

g285.seq 1 atgaccgata ccacaccgac agataccgat ccgaccgaaa acggcacgcg 51caaaatgccg tctgaacacc gccccgcccc gccggcaaaa aaacgccgcc 101 cgctgctgaagctgtcggcg gcactgctgt ctgtcctgat tttggcagta 151 tgtttcctcg gctggatcgccggtacggaa gcaggtttgc gcttcgggct 201 gtaccaaatc ccgtcctggt tcggcgtaaacatttcctcc caaaacctca 251 aaggcacact gctcgacggc ttcgacggcg acaactggtcgatagaaacc 301 gagggggcag accttaaaat cagccgcttc cgcttcgcgt ggaaaccgtc351 cgaactgatg cgccgcagcc tgcacatcac cgacatctcc gccggcgaca 401tcgccatcgt aaccaaaccg actccgccta aagaagaacg cccgcctcaa 451 ggcctgcccgacagcataga cctgcccgcc gctgtctatc tcgaccgctt 501 cgagacgggc aaaatcagcatgggcaaaac ctttgacaaa caaaccgtct 551 atctcgaacg cctcaacgcg gcataccgttacgaccgtaa agggcaccgc 601 ctcgacctga aggccgccga cacgccgtgg agcagttcgtcggggtcagc 651 ctcggtcggc ttgaaaaaac cgtttgccct cgataccgcc atttacacca701 aaggcggatt cgaaggcgaa accatacaca gtacggcgcg gctgagcggc 751agcctgaagg atgtgcgcgc cgaactgacg atcgacggcg gcaatatccg 801 cctctcgggaaaatccgtca tccacccgtt tgccgaatca ttggataaaa 851 cattggaaga agtactggtcaaaggattca acatcaatcc gtccgccttc 901 gtgccttccc tgcccgatgc cgggctgaatttcgacctga ccgccatccc 951 gtcgttttca gacggcatcg cgctggaagg ctcgctcgatttggaaaaca 1001 ccaaagccgg ctttgccgac cgcaacggca tccccgtccg tcaggttttg1051 ggcggctttg tcatccggca ggacggcacg gtgcatatcg gcaatacgtc 1101cgccgccctg ctcggacggg gcggcatcag gctgtcgggc aaaatcgaca 1151 ccgaaaaagacatccttgat ttaaatatag gcatcaactc cgtcggcgcg 1201 gaagacgtgc tgcaaaccgcgttcaaaggc aggttggacg gcagcatcgg 1251 catcggcggc acgaccgcct cgcccaaaatctcttggcaa ctcggcaccg 1301 gcacggcacg cacggacggc agcctcccca tcgcaagcgaccccgcaaac 1351 gaacagcgga aactggtgtt cgacaccgtc aacatctccg ccggggaagg1401 cagcctgacc gcgcaaggct atctcgagct gtttaaagac cgcctgctca 1451agctggacat ccgttcccgc gcattcgacc cttcgcgcat cgatccgcaa 1501 tttccggcaggcaatatcaa cggttcgatt catcttgccg gtgaactggc 1551 aaaagagaaa tttacgggcaaaatgcgttt tttgcccggt acgttcaacg 1601 gcgtgccgat tgccggcagc gccgacattgtttacgagtc ccgccacctt 1651 ccgcgcgccg ccgtcgattt gcggttgggg cggaacatcgtcaaaacaga 1701 cggcggcttc ggcaaaaaag gcgaccggct taacctcaat atcaccgcac1751 ccgatttatc ccgtttcggt ttcggactcg cggggtcttt aaatgtacgc 1801ggacaccttt ccggcgattt ggacggcggc atccgaacct ttgaaaccga 1851 cctttccggcacggcgcgca acttacacat cggcaaagcg gcagacatcc 1901 gttcgctcga ttttaccctcaaaggctcac ccggcacaag ccgcccgatg 1951 cgcgccgata tcaagggcgg ccgcctttccctgtcgggcg gcgcggcggt 2001 tgtcgatacc gccggcctga cgctggaagg tacgggcgcgcagcaccgca 2051 tccgcacaca cgccgccatg acgctggacg gcaaaccgtt caaactcgat2101 ttggacgctt caggcggcat caacagggaa cttacccgat ggaaaggcag 2151catcggcatc ctcgacatcg gcggcgcatt caacctcaag ctgcaaaacc 2201 gtatgacgctcgaagccggt gcggaacacg tggcggcaag tgcggcaaat 2251 tggcaggcaa tgggcggcagcctcaacctg caacactttt cttgggacag 2301 gaaaaccggc atatcggcaa aaggcggcgcacgcggcctg cacatcgccg 2351 agttgcacaa tttcttcaaa ccgcccttcg aacacaatctggttttaaac 2401 ggcgactggg atgtcgccta cgggcacaac gcgcgcggct acctcaatat2451 cagccggcaa agcggcgatg ccgtattgcc cggcgggcag gctttgggtt 2501tgaacgcatt ttccctgaaa acgcgctttc aaaacgaccg catcggaatc 2551 ctgcttgacggcggcgcgcg tttcggacgg attaacgccg atttgggcat 2601 cggcaacgcc ttcggcggcaatatggcaaa tacaccgctc ggcggcagga 2651 ttacagcctc ccttcccgac ttgggcgcattgaagccctt tctgcccgcc 2701 gccgcgcaaa acattaccgg cagcctgaat gcctccgcgcaaatcggcgg 2751 acgggtaggc tctccgtccg tcaatgccgc cgtcaacggt agcagcaact2801 acgggaaaat caacggcaat atcaccgtcg ggcaaagccg ctccttcgat 2851accgcacctt tgggcggcag gctcaacctg accgttgccg atgccgaagc 2901 attccgcaacttcctaccgg tcggacaaac cgtcaaaggc agcctgaatg 2951 ccgccgtaac cctcggcggcagcatcgccg acccgcactt gggcggcagt 3001 atcaacggcg acaagctcta ttaccgcaaccaaacccaag gcatcatctt 3051 ggacaacggc tcgctgcgtt cgcatattgc aggcaggaaatgggtaatcg 3101 acagcctgaa attccggcac gaagggacgg cggaactctc cggcacggtc3151 agcatggaaa acagcgtgcc cgatgtcgat atcggcgcgg tgttcgacaa 3201ataccgcatc ctgtcccgcc ccaaccgccg cctgacggtt tccggcaaca 3251 cccgcctgcgctattcgccg caaaaaggca tatccgttac cggtatgatt 3301 aaaactgatc aggggctgttcggttcgcaa aaatcctcga tgccgtccgt 3351 cggcgacgat gtcgtcgtat tgggcgaagtcaagaaagag gcggcggcat 3401 cgctccccgt caatatgaac ctgactttag acctcaatgacggcatccgc 3451 ttctccggct acggcgcgga cgttaccata ggcggcaaac tgaccctgac3501 cgcgcaaccg ggcggaaatg tgcgtggggt gggcacggtc cgcgtcatca 3551aagggcgtta caaagcatac gggcaggatt tagacattac caaaggcaca 3601 gtctcctttgtcggcccgct caacgacccc aacctgaaca tccgcgccga 3651 acgccgcctt tcccccgtcggtgcgggcgt ggaaatattg ggcagcctca 3701 acagcccgcg cattacgctg acggcaaacgaaccgatgag tgaaaaagac 3751 aagctctcct ggctcatcct caaccgtgcc ggcagcggcagcagcggcga 3801 caatgccgcc ctgtccgcag ccgcaggcgc gctgcttgcc gggcaaatca3851 acgaccgcat cgggctggtg gatgatttgg gctttaccag caagcgcagc 3901cgcaacgcgc aaaccggcga actcaacccc gccgaacagg tgctgaccgt 3951 cggcaaacaactgaccggca aactctacat cggctacgaa tacggcatct 4001 ccagcgcgga acagtccgtcaaactgattt accggctgac ccgcgccata 4051 caggcggttg cccgtatcgg cagccgttcgtcgggcggcg agctgacata 4101 caccatacgt ttcgaccgcc tcttcggttc ggacaaaaaagactccgcag 4151 gaaacggcaa agggaaataaThis corresponds to the amino acid sequence <SEQ ID 1182; ORF 285.ng>:

g285.pep 1 MTDTTPTDTD PTENGTRKMP SEHRPAPPAK KRRPLLKLSA ALLSVLILAV 51CFLGWIAGTE AGLRFGLYQI PSWFGVNISS QNLKGTLLDG FDGDNWSIET 101 EGADLKISRFRFAWKPSELM RRSLHITDIS AGDIAIVTKP TPPKEERPPQ 151 GLPDSIDLPA AVYLDRFETGKISMGKTFDK QTVYLERLNA AYRYDRKGHR 201 LDLKAADTPW SSSSGSASVG LKKPFALDTAIYTKGGFEGE TIHSTARLSG 251 SLKDVRAELT IDGGNIRLSG KSVIHPFAES LDKTLEEVLVKGFNINPSAF 301 VPSLPDAGLN FDLTAIPSFS DGIALEGSLD LENTKAGFAD RNGIPVRQVL351 GGFVIRQDGT VHIGNTSAAL LGRGGIRLSG KIDTEKDILD LNIGINSVGA 401EDVLQTAFKG RLDGSIGIGG TTASPKISWQ LGTGTARTDG SLPIASDPAN 451 EQRKLVFDTVNISAGEGSLT AQGYLELFKD RLLKLDIRSR AFDPSRIDPQ 501 FPAGNINGSI HLAGELAKEKFTGKMRFLPG TFNGVPIAGS ADIVYESRHL 551 PRAAVDLRLG RNIVKTDGGF GKKGDRLNLNITAPDLSRFG FGLAGSLNVR 601 GHLSGDLDGG IRTFETDLSG TARNLHIGKA ADIRSLDFTLKGSPGTSRPM 651 RADIKGGRLS LSGGAAVVDT AGLTLEGTGA QHRIRTHAAM TLDGKPFKLD701 LDASGGINRE LTRWKGSIGI LDIGGAFNLK LQNRMTLEAG AEHVAASAAN 751WQAMGGSLNL QHFSWDRKTG ISAKGGARGL HIAELHNFFK PPFEHNLVLN 801 GDWDVAYGHNARGYLNISRQ SGDAVLPGGQ ALGLNAFSLK TRFQNDRIGI 851 LLDGGARFGR INADLGIGNAFGGNMANTPL GGRITASLPD LGALKPFLPA 901 AAQNITGSLN ASAQIGGRVG SPSVNAAVNGSSNYGKINGN ITVGQSRSFD 951 TAPLGGRLNL TVADAEAFRN FLPVGQTVKG SLNAAVTLGGSIADPHLGGS 1001 INGDKLYYRN QTQGIILDNG SLRSHIAGRK WVIDSLKFRH EGTAELSGTV1051 SMENSVPDVD IGAVFDKYRI LSRPNRRLTV SGNTRLRYSP QKGISVTGMI 1101KTDQGLFGSQ KSSMPSVGDD VVVLGEVKKE AAASLPVNMN LTLDLNDGIR 1151 FSGYGADVTIGGKLTLTAQP GGNVRGVGTV RVIKGRYKAY GQDLDITKGT 1201 VSFVGPLNDP NLNIRAERRLSPVGAGVEIL GSLNSPRITL TANEPMSEKD 1251 KLSWLILNRA GSGSSGDNAA LSAAAGALLAGQINDRIGLV DDLGFTSKRS 1301 RNAQTGELNP AEQVLTVGKQ LTGKLYIGYE YGISSAEQSVKLIYRLTRAI 1351 QAVARIGSRS SGGELTYTIR FDRLFGSDKK DSAGNGKGK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1183>:

m285.seq 1 ATGACCGATA CCGCACCGAC AGATACCGAT CCGACCGAAA ACGGCACGCG 51CAAAATGCCG TCTGAACACC GCCCTACCCC GCCGGCAAAA AAACGCCGCC 101 CGTTGCTGAAGCTGTCGGCG GCACTGCTGT CTGTCCTGAT TTTGGCAGTA 151 TGTTTCCTCG GCTGGCTCGCCGGTACGGAA GCAGGTTTGC GCTTCGGGCT 201 GTACCAAATC CCGTCTTGGT TCGGCGTAAACATTTCCTCC CAAAACCTCA 251 AAGGCACGCT GCTCGACGGC TTCGACGGCG ACAACTGGTCGATAGAAACC 301 GAGGGGGCAG ACCTTAAAAT CAGCCGCTTC CGCTTCGCGT GGAAACCGTC351 CGAACTGATG CGCCGCAGCC TGCACATTAC CGAAATTTCC GCCGGCGACA 401TCGCCATCGT TACCAAACCG ACTCCGCCTA AAGAAGAACG CCCGCCGCTC 451 AGCCTTCCCGACAGCATAGA CCTGCCTGCC GCCGTCTATC TCGACCGCTT 501 CGAGACGGGC AAAATCAGCATGGGCAAAGC CTTTGACAAA CAAACCGTCT 551 ATCTCGAACG GCTGGATGCT TCATACCGTTACGACCGCAA AGGACACCGC 601 CTTGACCTGA AGGCCGCCGA CACGCCGTGG AGCAGTTCGTCGGGGGCGGC 651 CTCGGTCGGC TTGAAAAAAC CGTTTGCCCT CGATACCGCC ATTTACACCA701 AAGGCGGACT CGAAGGCAAA ACCATACACA GTACGGCTCG GCTGAGCGGC 751AGCCTGAAGG ATGTGCGCGC CGAACTGGCG ATCGACGGCG GCAATATCCG 801 CCTCTCGGGAAAATCCGTCA TCCACCCGTT TGCCGAATCA TTGGATAAAA 851 CATTGGAAGA AGTACTGGTCAAAGGGTTCA ACATCAATCC GGCCGCCTTC 901 GTGCCTTCCC TGCCCGATGC CGGACTGAATTTCGACCTGA CCGCCATCCC 951 GTCGTTTTCA GACGGCATCG CGCTGGAAGG TTCGCTCGATTTGGAAAACA 1001 CCAAAGCCGG CTTTGCCGAC CGCAACGGCA TCCCCGTCCG TCAGGTTTTA1051 GGCGGCTTTG TCATCCGGCA GGACGGCACG GTGCATATCG GCAATACGTC 1101CGCCGCCCTG CTCGGACGGG GCGGCATCAG GCTGTCGGGC AAAATCGACA 1151 CCGAAAAAGACATCCTCGAT TTAAATATAG GCATCAACTC CGTCGGCGCG 1201 GAAGACGTAC TGCAAACCGCGTTCAAAGGC AGGTTGGACG GCAGCATCGG 1251 CATCGGTGGC ACGACCGCCT CGCCCAAAATCTCTTGGCAA CTCGGCATCG 1301 GCACGGCGCG CACGGACGGC AGCCTCGCCA TTGCAAGCGACCCAGCAAAC 1351 GGACAGCGGA AACTGGTGCT CGACACCGTC AACATCGCCG CCGGGCAAGG1401 CAGCCTGACC GCGCAAGGCT ATCTCGAGCT GTTTAAAGAC CGCCTGCTCA 1451AGCTGGACAT CCGTTCCCGC GCATTCGACC CTTCGCGCAT CGATCCGCAA 1501 CTTCCGGCAGGCAATATCAA CGGCTCAATA AACCTTGCCG GCGAACTGGC 1551 AAAAGAGAAA TTCACAGGCAAAATGCGGTT TTTACCCGGC ACGTTCAACG 1601 GCGTACCGAT TGCCGGCAGT GCCGACATTGTTTACGAGTC CCGCCACCTT 1651 CCGCGTGCCG CCGTCGATTT GCGGCTGGGG CGGAACATTATTAAAACAGA 1701 CGGCGGCTTC GGCAAAAAAG GCGACCGGCT TAACCTCAAT ATCACCGCAC1751 CCGATTTATC CCGTTTCGGT TTCGGACTCG CGGGGTCTTT AAATGTACGC 1801GGACACCTTT CCGGTGATTT GGACGGCGGC ATCCGAACCT TTGAAACCGA 1851 CCTTTCCGGCGCGGCGCGCA ACCTGCACAT CGGCAAGGCG GCAGACATCC 1901 GTTCGCTCGA TTTCACGCTCAAAGGTTCGC CCGACACAAG CCGCCCGATA 1951 CGCGCCGACA TCAAAGGCAG CCGCCTTTCGCTGTCGGGCG GAGCGGCGGT 2001 TGTCGATACC GCCGACCTGA TGCTGGACGG CACGGGCGTGCAGCACCGCA 2051 TCCGCACACA CGCCGCCATG ACGCTGGATG GCAAACCGTT CAAATTCGAT2101 TTGGACGCTT CAGGCGGCAT CAACAGGGAA CTTACCCGAT GGAAAGGCAG 2151CATCGGCATC CTCGACATCG GCGGCGCATT CAACCTCAAG CTGCAAAACC 2201 GTATGACGCTCGAAGCCGGT GCGGAACGCG TGGCGGCAAG TGCGGCAAAT 2251 TGGCAGGCAA TGGGCGGCAGCCTCAACCTG CAACACTTTT CTTGGGATAA 2301 AAAAACCGGC ATATCGGCAA AAGGCGGCGCACACGGTCTG CATATCGCCG 2351 AGTTGCACAA TTTCTTCAAA CCGCCCTTCG AACACAATCTGGTTTTAAAC 2401 GGCGACTGGG ATGTCGCCTA CGGGCGCAAC GCGCGCGGCT ACCTCAATAT2451 CAGCCGGCAA AGCGGCGATG CCGTATTGCC CGGCGGGCAG GCTTTGGGTT 2501TGAACGCATT TTCCCTGAAA ACGCGCTTTC AAAACGACCG CATCGGAATC 2551 CTGCTTGACGGCGGCGCGCG TTTCGGGCGG ATTAACGCCG ATTTGGGCAT 2601 CGCCAACGCC TTCGGCGGCAATATGGCAAA TGCACCGCTC GGCGGCAGGA 2651 TTACCGCCTC CCTTCCCGAC TTGGGCGCATTGAAGCCCTT TCTGCCCGCC 2701 GCCGCGCAAA ACATTACCGG CAGCCTGAAT GCCGCCGCGCAAATCGGCGG 2751 ACGGGTAGGC TCTCCGTCCG TCAATGCCGC CGTCAACGGC AGCAGCAACT2801 ACGGGAAAAT CAACGGCAAC ATCACCGTCG GGCAAAGCCG CTCTTTCGAT 2851ACCGCGCCTT TGGGCGGCAG GCTCAACCTG ACCGTTGCCG ATGCCGAAGT 2901 ATTCCGCAACTTCCTACCGG TCGGACAAAC CGTCAAAGGC AGCCTGAATG 2951 CCGCCGTAAC CCTCGGCGGCAGCATCGCCG ATCCGCACTT GGGCGGCAGC 3001 ATCAACGGCG ACAAACTCTA TTACCGCAACCAAACCCAAG GCATCATCTT 3051 GGACAACGGC TCGCTGCGTT CGCATATCGC GGGCAGGAAATGGGTAATCG 3101 ACAGCCTGAA ATTCCGGCAC GAAGGGACGG CGGAACTCTC CGGTACGGTC3151 GGTATGGAAA ACAGCGGACC CGATGTCGAT ATCGGCGCGG TGTTCGACAA 3201ATACCGCATC CTGTCCCGCC CCAACCGCCG CCTGACGGTT TCCGGCAACA 3251 CCCGCCTGCGCTATTCGCCG CAAAAAGGCA TATCCGTTAC CGGGATGATT 3301 AAAACGGATC AGGGGCTGTTCGGTTCGCAA AAATCCTCGA TGCCGTCCGT 3351 CGGCGACGAT GTCGTCGTAT TAGGCGAAGTCAAAAAAGAG GCGGCGGCAC 3401 CGCTCCCCGT CAATATGAAC CTGACTTTAG ACCTCAATGACGGCATCCGC 3451 TTCGCCGGCT ACGGCGCGGA CGTTACCATA GGCGGCAAAC TGACCCTGAC3501 CGCCCAATCG GGCGGAAGCG TACGGGGCGT GGGCACGGTC CGCGTCATCA 3551AAGGGCGTTA TAAGGCATAC GGGCAGGATT TGGACATTAC CAAAGGCACG 3601 GTCTCCTTTGTCGGCCCGCT CAACGATCCC AACCTCAACA TCCGCGCCGA 3651 ACGCCGCCTT TCCCCCGTCGGTGCGGGCGT GGAAATATTG GGCAGCCTCA 3701 ACAGCCCGCG CATTACGCTG ACGGCAAACGAACCGATGAG TGAAAAAGAC 3751 AAGCTCTCTT GGCTCATCCT CAACCGCGCC GGCAGCGGCAGCAGCGGCGA 3801 CAATGCCGCC CTGTCTGCAG CCGCAGGTGC GCTGCTTGCC GGGCAAATCA3851 ACGACCGCAT CGGGCTGGTG GATGATTTGG GCTTTACCAG CAAGCGCAGC 3901CGCAACGCGC AAACCGGCGA ACTCAACCCC GCCGAACAGG TGCTGACCGT 3951 CGGCAAACAACTGACCGGCA AACTCTACAT CGGCTACGAA TACAGCATCT 4001 CCAGCGCGGA ACAGTCCGTCAAACTGATTT ACCGGCTGAC CCGCGCCATA 4051 CAGGCGGTTG CCCGTATCGG CAGCCGTTCGTCGGGCGGCG AGCTGACATA 4101 CACCATACGT TTCGACCGCT TCTCCGGTTC GGACAAAAAAGACTCCGCCG 4151 GAAACGGCAA AGGAAAATAAThis corresponds to the amino acid sequence <SEQ ID 1184; ORF 285>:

m285.pep 1 MTDTAPTDTD PTENGTRKMP SEHRPTPPAK KRRPLLKLSA ALLSVLILAV 51CFLGWLAGTE AGLRFGLYQI PSWFGVNISS QNLKGTLLDG FDGDNWSIET 101 EGADLKISRFRFAWKPSELM RRSLHITEIS AGDIAIVTKP TPPKEERPPL 151 SLPDSIDLPA AVYLDRFETGKISMGKAFDK QTVYLERLDA SYRYDRKGHR 201 LDLKAADTPW SSSSGAASVG LKKPFALDTAIYTKGGLEGK TIHSTARLSG 251 SLKDVRAELA IDGGNIRLSG KSVIHPFAES LDKTLEEVLVKGFNINPAAF 301 VPSLPDAGLN FDLTAIPSFS DGIALEGSLD LENTKAGFAD RNGIPVRQVL351 GGFVIRQDGT VHIGNTSAAL LGRGGIRLSG KIDTEKDILD LNIGINSVGA 401EDVLQTAFKG RLDGSIGIGG TTASPKISWQ LGIGTARTDG SLAIASDPAN 451 GQRKLVLDTVNIAAGQGSLT AQGYLELFKD RLLKLDIRSR AFDPSRIDPQ 501 LPAGNINGSI NLAGELAKEKFTGKMRFLPG TFNGVPIAGS ADIVYESRHL 551 PRAAVDLRLG RNIIKTDGGF GKKGDRLNLNITAPDLSRFG FGLAGSLNVR 601 GHLSGDLDGG IRTFETDLSG AARNLHIGKA ADIRSLDFTLKGSPDTSRPI 651 RADIKGSRLS LSGGAAVVDT ADLMLDGTGV QHRIRTHAAM TLDGKPFKFD701 LDASGGINRE LTRWKGSIGI LDIGGAFNLK LQNRMTLEAG AERVAASAAN 751WQAMGGSLNL QHFSWDKKTG ISAKGGAHGL HIAELHNFFK PPFEHNLVLN 801 GDWDVAYGRNARGYLNISRQ SGDAVLPGGQ ALGLNAFSLK TRFQNDRIGI 851 LLDGGARFGR INADLGIANAFGGNMANAPL GGRITASLPD LGALKPFLPA 901 AAQNITGSLN AAAQIGGRVG SPSVNAAVNGSSNYGKINGN ITVGQSRSFD 951 TAPLGGRLNL TVADAEVFRN FLPVGQTVKG SLNAAVTLGGSIADPHLGGS 1001 INGDKLYYRN QTQGIILDNG SLRSHIAGRK WVIDSLKFRH EGTAELSGTV1051 GMENSGPDVD IGAVFDKYRI LSRPNRRLTV SGNTRLRYSP QKGISVTGMI 1101KTDQGLFGSQ KSSMPSVGDD VVVLGEVKKE AAAPLPVNMN LTLDLNDGIR 1151 FAGYGADVTIGGKLTLTAQS GGSVRGVGTV RVIKGRYKAY GQDLDITKGT 1201 VSFVGPLNDP NLNIRAERRLSPVGAGVEIL GSLNSPRITL TANEPMSEKD 1251 KLSWLILNRA GSGSSGDNAA LSAAAGALLAGQINDRIGLV DDLGFTSKRS 1301 RNAQTGELNP AEQVLTVGKQ LTGKLYIGYE YSISSAEQSVKLIYRLTRAI 1351 QAVARIGSRS SGGELTYTIR FDRFSGSDKK DSAGNGKGK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m285/g285 96.5% identity in 1389 aa overlap        10        20        30        40        50        60 m285.pepMTDTAPTDTDPTENGTRKMPSEHRPTPPAKKRRPLLKLSAALLSVLILAVCFLGWLAGTE||||:||||||||||||||||||||:|||||||||||||||||||||||||||||:|||| 8285MTDTTPTDTDPTENGTRKMPSEHRPAPPAKKRRPLLKLSAALLSVLILAVCFLGWIAGTE        10        20        30        40        50        60        70        80        90       100       110       120 m285.pepAGLRFGLYQIPSWFGVNISSQNLKGTLLDGFDGDNWSIETEGADLKISRFRFAWKPSELM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g285AGLRFGLYQIPSWFGVNISSQNLKGTLLDGFDGDNWSIETEGADLKISRFRFAWKPSELM        70        80        90       100       110       120       130       140       150       160       170       180 m285.pepRRSLHITEISAGDIAIVTKPTPPKEERPPLSLPDSIDLPAAVYLDRFETGKISMGKAFDK|||||||:||||||||||||||||||||| :|||||||||||||||||||||||||:||| g285RRSLHITDISAGDIAIVTKPTPPKEERPPQGLPDSIDLPAAVYLDRFETGKISMGKTFDK       130       140       150       160       170       180       190       200       210       220       230       240 m285.pepQTVYLERLDASYRYDRKGHRLDLKAADTPWSSSSGAASVGLKKPFALDTAIYTKGGLEGK||||||||:|:||||||||||||||||||||||||:||||||||||||||||||||:||: g285QTVYLERLNAAYRYDRKGHRLDLKAADTPWSSSSGSASVGLKKPFALDTAIYTKGGFEGE       190       200       210       220       230       240       250       260       270       280       290       300 m285.pepTIHSTARLSGSLKDVRAELAIDGGNIRLSGKSVIHPFAESLDKTLEEVLVKGFNINPAAF|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||:|| g285TIHSTARLSGSLKDVRAELTIDGGNIRLSGKSVIHPFAESLDKTLEEVLVKGFNINPSAF       250       260       270       280       290       300       310       320       330       340       350       360 m285.pepVPSLPDAGLNFDLTAIPSFSDGIALEGSLDLENTKAGFADRNGIPVRQVLGGFVIRQDGT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g285VPSLPDAGLNFDLTAIPSFSDGIALEGSLDLENTKAGFADRNGIPVRQVLGGFVIRQDGT       310       320       330       340       350       360       370       380       390       400       410       420 m285.pepVHIGNTSAALLGRGGIRLSGKIDTEKDILDLNIGINSVGAEDVLQTAFKGRLDGSIGIGG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g285VHIGNTSAALLGRGGIRLSGKIDTEKDILDLNIGINSVGAEDVLQTAFKGRLDGSIGIGG       370       380       390       400       410       420       430       440       450       460       470       480 m285.pepTTASPKISWQLGIGTARTDGSLAIASDPANGQRKLVLDTVNIAAGQGSLTAQGYLELFKD|||||||||||| ||||||||| ||||||| |||||:|||||:||:|||||||||||||| g285TTASPKISWQLGTGTARTDGSLPIASDPANEQRKLVFDTVNISAGEGSLTAQGYLELFKD       430       440       450       460       470       480       490       500       510       520       530       540 m285.pepRLLKLDIRSRAFDPSRIDPQLPAGNINGSINLAGELAKEKFTGKMRFLPGTFNGVPIAGS||||||||||||||||||||:|||||||||:||||||||||||||||||||||||||||| g285RLLKLDIRSRAFDPSRIDPQFPAGNINGSIHLAGELAKEKFTGKMRFLPGTFNGVPIAGS       490       500       510       520       530       540       550       560       570       580       590       600 m285.pepADIVYESRHLPRAAVDLRLGRNIIKTDGGFGKKGDRLNLNITAPDLSRFGFGLAGSLNVR|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| g285ADIVYESRHLPRAAVDLRLGRNIVKTDGGFGKKGDRLNLNITAPDLSRFGFGLAGSLNVR       550       560       570       580       590       600       610       620       630       640       650       660 m285.pepGHLSGDLDGGIRTFETDLSGAARNLHIGKAADIRSLDFTLKGSPDTSRPIRADIKGSRLS||||||||||||||||||||:||||||||||||||||||||||| ||||:||||||:||| g285GHLSGDLDGGIRTFETDLSGTARNLHIGKAADIRSLDFTLKGSPGTSRPMRADIKGGRLS       610       620       630       640       650       660       670       680       690       700       710       720 m285.pepLSGGAAVVDTADLMLDGTGVQHRIRTHAAMTLDGKPFKFDLDASGGINRELTRWKGSIGI||||||||||| | |:|||:||||||||||||||||||:||||||||||||||||||||| g285LSGGAAVVDTAGLTLEGTGAQHRIRTHAAMTLDGKPFKLDLDASGGINRELTRWKGSIGI       670       680       690       700       710       720       730       740       750       760       770       780 m285.pepLDIGGAFNLKLQNRMTLEAGAERVAASAANWQAMGGSLNLQHFSWDKKTGISAKGGAHGL||||||||||||||||||||||: |||||||||||||||||||||||: ||||||||||: || g285LDIGGAFNLKLQNRMTLEAGAEHVAASAANWQAMGGSLNLQHFSWDRKTGISAKGGARGL       730       740       750       760       770       780       790       800       810       820       830       840 m285.pepHIAELHNFFKPPFEHNLVLNGDWDVAYGRNARGYLNISRQSGDAVLPGGQALGLNAFSLK||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||| g285HIAELHNFFKPPFEHNLVLNGDWDVAYGHNARGYLNISRQSGDAVLPGGQALGLNAFSLK       790       800       810       820       830       840       850       860       870       880       890       900 m285.pepTRFQNDRIGILLDGGARFGRINADLGIANAFGGNMANAPLGGRITASLPDLGALKPFLPA|||||||||||||||||||||||||||:|||||||||:|||||||||||||||||||||| g285TRFQNDRIGILLDGGARFGRINADLGIGNAFGGNMANTPLGGRITASLPDLGALKPFLPA       850       860       870       880       890       900       910       920       930       940       950       960 m285.pepAAQNITGSLNAAAQIGGRVGSPSVNAAVNGSSNYGKINGNITVGQSRSFDTAPLGGRLNL|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||| g285AAQNITGSLNASAQIGGRVGSPSVNAAVNGSSNYGKINGNITVGQSRSFDTAPLGGRLNL       910       920       930       940       950       960       970       980       990      1000      1010      1020 m285.pepTVADAEVFRNFLPVGQTVKGSLNAAVTLGGSIADPHLGGSINGDKLYYRNQTQGIILDNG||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||| g285TVADAEAFRNFLPVGQTVKGSLNAAVTLGGSIADPHLGGSINGDKLYYRNQTQGIILDNG       970       980       990      1000      1010      1020      1030      1040      1050      1060      1070      1080 m285.pepSLRSHIAGRKWVIDSLKFRHEGTAELSGTVGMENSGPDVDIGAVFDKYRILSRPNRRLTV||||||||||||||||||||||||||||||:|||| |||||||||||||||||||||||| g285SLRSHIAGRKWVIDSLKFRHEGTAELSGTVSMENSVPDVDIGAVFDKYRILSRPNRRLTV      1030      1040      1050      1060      1070      1080      1090      1100      1110      1120      1130      1140 m285.pepSGNTRLRYSPQKGISVTGMIKTDQGLFGSQKSSMPSVGDDVVVLGEVKKEAAAPLPVNMN||||||||||||||||||||||||||||||||||||||||||||||||||||| |||||| g285SGNTRLRYSPQKGISVTGMIKTDQGLFGSQKSSMPSVGDDVVVLGEVKKEAAASLPVNMN      1090      1100      1110      1120      1130      1140      1150      1160      1170      1180      1190      1200 m285.pepLTLDLNDGIRFAGYGADVTIGGKLTLTAQSGGSVRGVGTVRVIKGRYKAYGQDLDITKGT|||||||||||:||||||||||||||||| ||:||||||||||||||||||||||||||| g285LTLDLNDGIRFSGYGADVTIGGKLTLTAQPGGNVRGVGTVRVIKGRYKAYGQDLDITKGT      1150      1160      1170      1180      1190      1200      1210      1220      1230      1240      1250      1260 m285.pepVSFVGPLNDPNLNIRAERRLSPVGAGVEILGSLNSPRITLTANEPMSEKDKLSWLILNRA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g285VSFVGPLNDPNLNIRAERRLSPVGAGVEILGSLNSPRITLTANEPMSEKDKLSWLILNRA      1210      1220      1230      1240      1250      1260      1270      1280      1290      1300      1310      1320 m285.pepGSGSSGDNAALSAAAGALLAGQINDRIGLVDDLGFTSKRSRNAQTGELNPAEQVLTVGKQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g285GSGSSGDNAALSAAAGALLAGQINDRIGLVDDLGFTSKRSRNAQTGELNPAEQVLTVGKQ      1270      1280      1290      1300      1310      1320      1330      1340      1350      1360      1370      1380 m285.pepLTGKLYIGYEYSISSAEQSVKLIYRLTRAIQAVARIGSRSSGGELTYTIRFDRFSGSDKK|||||||||||:|||||||||||||||||||||||||||||||||||||||||: ||||| g285LTGKLYIGYEYGISSAEQSVKLIYRLTRAIQAVARIGSRSSGGELTYTIRFDRLFGSDKK      1330      1340      1350      1360      1370      1380       1390m285.pep DSAGNGKGKX |||||||||| g285 DSAGNGKGKXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1185>:

a285.seq 1 ATGACCGATA CCGCACCGAC AGATACCGAT CCGACCGAAA ACGGCACGCG 51CAAAATGCCG TCTGAACACC GCCCTACCCC GCCGGCAAAA AAACGCCGCC 101 CGCTGCTGAAGCTGTCGGCG GCACTGCTGT CTGTTCTGAT TTTGGCAGTA 151 TGTTTCCTCG GCTGGCTCGCCGGCACGGAA GCGGGTTTGC GCTTCGGGCT 201 GTACCAAATC CCGTCTTGGT TCGGCGTAAACATTTCCTCC CAAAACCTCA 251 AAGGCACGCT GCTCGACGGC TTCGACGGCG ACAACTGGTCGATAGAAACC 301 GAGGGGGCAG ACCTTAAAAT CAGCCGCTTC CGCTTCGCGT GGAAACCGTC351 CGAACTGATG CGCCGCAGCC TGCACATTAC CGAAATTTCC GCCGGCGACA 401TCGCCATCGT TACCAAACCG ACTCCGCCTA AAGAAGAACG CCCGCCGCTC 451 AGCCTTCCCGACAGCATAGA CCTGCCTGCC GCCGTCTATC TCGACCGCTT 501 CGAGACGGGC AAAATCAGCATGGGCAAAGC CTTTGACAAA CAAACCGTCT 551 ATCTCGAACG GCTGGATGCT TCATACCGTTACGACCGCAA AGGACACCGC 601 CTCGACCTGA AGGCTGCCGA CACGCCGTGG AGCAGTTCGTCGGGGTCAGC 651 CTCGGTCGGC TTGAAAAAAC CGTTTGCCCT CGATACCGCC ATTTACACCA701 AAGGCGGACT CGAAGGCAAA ACCATACACA GTACGGCTCG GCTGAGCGGC 751AGCCTGAAGG ATGTGCGCGC CGAACTGGCG ATCGACGGCG GCAATATCCG 801 CCTCTCGGGAAAATCCGTCA TCCACCCGTT TGCCGAATCA TTGGATAAAA 851 CATTGGAAGA AGTACTGGTCAAAGGGTTCA ACATCAATCC GTCCGCCTTC 901 GTGCCTTCCC TGCCCGATGC CGGGCTGAATTTCGACCTGA CCGCCATCCC 951 GTCGTTTTCA GACGGCATCG CGCTGGAAGG CTCGCTCGATTTGGAAAACA 1001 CCAAAGCCGG CTTTGCCGAC CGCAACGGCA TCCCCGTCCG TCAGGTTTTA1051 GGCAGCTTTG TCATCCGGCA GGACGGCACG GTGCATATCG GCAATACGTC 1101CGTCGCCCTG CTCGGACGGG GCGGCATCAG GCTGTCGGGC AAAATCGACA 1151 CCGAAAAAGACATCCTCGAT TTAAATATAG GCATCAACTC CGTCGGCGCG 1201 GAAGACGTAC TGCAAACCGCGTTCAAAGGC AGGTTGGACG GCAGCATCGG 1251 CATCGGTGGC ACGACCGCCT CGCCCAAAATCTCTTGGCAA CTCGGCATCG 1301 GCACGGCGCG CACGGACGGC AGCCTCGCCA TTGCAAGCGACCCCGCAAAC 1351 GGACAGCGGA AACTGGTGCT CGACACCGTC AACATCGCCG CCGGGCAAGG1401 CAGCCTGACC GCGCAAGGCT ATCTCGAGCT GTTTAAAGAC CGCCTGCTCA 1451AGCTGGACAT CCGTTCCCGC GCATTCGACC CTTCGCGCAT CGATCCGCAA 1501 CTTCCGGCAGGCAATATCAA CGGCTCAATA AACCTTGCCG GCGAACTGGC 1551 AAAAGAGAAA TTCACAGGCAAAATGCGGTT TTTACCCGGC ACGTTCAACG 1601 GCGTACCGAT TGCCGGCAGT GCCGACATTGTTTACGAGTC CCGCCACCTT 1651 CCGCGTGCCG CCGTCGATTT GCGGCTGGGG CGGAACATTATTAAAACAGA 1701 CGGCGGCTTC GGCAAAAAAG GCGACCGGCT TAACCTCAAT ATCACCGCAC1751 CCGATTTATC CCGTTTCGGT TTCGGACTCG CGGGGTCTTT AAATGTACGC 1801GGACACCTTT CCGGCGATTT GGACGGTGGC ATCCGAACCT TTGAAACCGA 1851 CCTTTCCGGCGCGGCGCGCA ACCTGCACAT CGGCAAGGCG GCAGACATCC 1901 GTTCGCTCGA TTTCACGCTCAAAGGTTCGC CCGACACAAG CCGCCCGATA 1951 CGCGCCGACA TCAAAGGCAG CCGCCTTTCGCTGTCGGGCG GAGCGGAGGT 2001 TGTCGATACC GCCGACCTGA TGCTGGACGG CACGGGCGTGCAGCACCGCA 2051 TCCGCACACA CGCCGCCATG ACGCTGGATG GCAAACCGTT CAAATTCGAT2101 TTGGACGCTT CAGGCGGCAT CAACAGGGAA CTTACCCGAT GGAAAGGCAG 2151CATCGGCATC CTCGACATCG GCGGCGCATT CAACCTCAAG CTGCAAAACC 2201 GTATGACGCTCGAAGCCGGT GCGGAACGCG TGGCGGCAAG TGCGGCAAAT 2251 TGGCAGGCAA TGGGCGGCAGCCTCAACCTG CAACACTTTT CTTGGGATAA 2301 AAAAACCGGC ATATCGGCAA AAGGCGGCGCACACGGTCTG CATATCGCCG 2351 AGTTGCACAA TTTCTTCAAA CCGCCCTTCG AACACAATCTGGTTTTAAAC 2401 GGCGACTGGG ATGTCGCCTA CGGGCGAAAC GCGCGCGGCT ACCTCAATAT2451 CAGCCGGCAA AGCGGCGATG CCGTATTGCC CGGCGGGCAG GCTTTGGGTT 2501TGAACGCATT TTCCCTGAAA ACGCGCTTTC AAAACGACCG TATCGGAATC 2551 CTGCTTGACGGCGGCGCGCG TTTCGGGCGG ATTAACGCCG ATTTGGACAT 2601 CGGCAACGCC TTCGGCGGCAATATGGCAAA TGCACCGCTC GGCGGCAGGA 2651 TTACCGCCTC CCTTCCCGAC TTGGGCACATTGAAGCCCTT TCTGCCCGCC 2701 GCCGCGCAAA ACATTACCGG CAGCCTGAAT GCCGCCGCGCAAATCGGCGG 2751 ACGGGTCGGC TCTCCGTCCG TCAATGCCGC CGTCAACGGC AGCAGCAACT2801 ACGGGAAAAT CAACGGCAAC ATCACCGTCG GGCAAAGCCG CTCTTTCGAT 2851ACCGCGCCTT TGGGCGGCAG GCTCAACCTG ACCGTTGCCG ATGCCGAAGT 2901 ATTCCGCAACTTCCTACCGG TCGGACAAAC CGTCAAAGGC AGCCTGAATG 2951 CCGCCGTAAC CCTCGGCGGCAGCATCGCCG ATCCGCACTT GGGCGGCAGC 3001 ATCAACGGCG ACAAACTCTA TTACCGCAACCAAACCCAAG GCATCATCTT 3051 GGACAACGGC TCGCTGCGTT CGCATATCGC GGGCAGGAAATGGGTAATCG 3101 ACAGCCTGAA ATTCCGGCAC GAAGGGACGG CGGAACTCTC CGGTACGGTC3151 GGTATGGAAA ACAGCGGACC CGATGTCGAT ATCGGCGCGG TGTTCGACAA 3201ATACCGCATC CTGTCCCGCC CCAACCGCCG CCTGACGGTT TCCGGCAACA 3251 CCCGCCTGCGCTATTCGCCG CAAAAAGGCA TATCCGTTAC CGGGATGATT 3301 AAAACGGATC AGGGGCTGTTCGGTTCGCAA AAATCCTCGA TGCCGTCCGT 3351 CGGCGACGAT GTCGTCGTAT TAGGCGAAGTCAAAAAAGAG GCGGCGGCAC 3401 CGCTCCCCGT CAATATGAAC CTGACTTTAG ACCTCAATGACGGCATCCGC 3451 TTCGCCGGCT ACGGCGCGGA CGTTACCATA GGCGGCAAAC TGACCCTGAC3501 CGCCCAATCG GGCGGAAGCG TGCGGGGCGT GGGCACGGTC CGCGTCATCA 3551AAGGGCGTTA TAAGGCATAC GGGCAGGATT TGGACATTAC CAAAGGCACG 3601 GTCTCCTTTGTCGGCCCGCT CAACGACCCC AACCTCAACA TCCGCGCCGA 3651 ACGCCGCCTT TCCCCCGTCGGTGCGGGCGT GGAAATATTG GGCAGCCTCA 3701 ACAGTCCGCG CATTACGCTG ACGGCAAACGAACCGATGAG TGAAAAAGAC 3751 AAGCTCTCCT GGCTCATCCT CAACCGCGCC GGCAGTGGCAGCAGCGGCGA 3801 CAATGCCGCC CTGTCCGCAG CCGCCGGCGC GCTGCTTGCC GGGCAAATCA3851 ACGACCGCAT CGGGCTGGTG GATGATTTGG GCTTTACCAG CAAGCGCAGC 3901CGCAACGCGC AAACCGGCGA ACTCAACCCC GCCGAACAGG TGCTGACCGT 3951 CGGCAAACAACTGACCGGCA AACTCTACAT CGGCTACGAA TACAGCATCT 4001 CCAGCGCGGA ACAGTCCGTCAAACTGATTT ACCGGCTGAC CCGCGCCATA 4051 CAGGCGGTTG CCCGTATCGG CAGCCGTTCGTCGGGCGGCG AGCTGACATA 4101 CACCATACGT TTCGACCGCT TCTCCGGTTC GGACAAAAAAGACTCCGCCG 4151 GAAACAGCAA AGGAAAATAAThis corresponds to the amino acid sequence <SEQ ID 1186; ORF 285.a>:

a285.pep 1 MTDTAPTDTD PTENGTRKMP SEHRPTPPAK KRRPLLKLSA ALLSVLILAV 51CFLGWLAGTE AGLRFGLYQI PSWFGVNISS QNLKGTLLDG FDGDNWSIET 101 EGADLKISRFRFAWKPSELM RRSLHITEIS AGDIAIVTKP TPPKEERPPL 151 SLPDSIDLPA AVYLDRFETGKISMGKAFDK QTVYLERLDA SYRYDRKGHR 201 LDLKAADTPW SSSSGSASVG LKKPFALDTAIYTKGGLEGK TIHSTARLSG 251 SLKDVRAELA IDGGNIRLSG KSVIHPFAES LDKTLEEVLVKGFNINPSAF 301 VPSLPDAGLN FDLTAIPSFS DGIALEGSLD LENTKAGFAD RNGIPVRQVL351 GSFVIRQDGT VHIGNTSVAL LGRGGIRLSG KIDTEKDILD LNIGINSVGA 401EDVLQTAFKG RLDGSIGIGG TTASPKISWQ LGIGTARTDG SLAIASDPAN 451 GQRKLVLDTVNIAAGQGSLT AQGYLELFKD RLLKLDIRSR AFDPSRIDPQ 501 LPAGNINGSI NLAGELAKEKFTGKMRFLPG TFNGVPIAGS ADIVYESRHL 551 PRAAVDLRLG RNIIKTDGGF GKKGDRLNLNITAPDLSRFG FGLAGSLNVR 601 GHLSGDLDGG IRTFETDLSG AARNLHIGKA ADIRSLDFTLKGSPDTSRPI 651 RADIKGSRLS LSGGAEVVDT ADLMLDGTGV QHRIRTHAAM TLDGKPFKFD701 LDASGGINRE LTRWKGSIGI LDIGGAFNLK LQNRMTLEAG AERVAASAAN 751WQAMGGSLNL QHFSWDKKTG ISAKGGAHGL HIAELHNFFK PPFEHNLVLN 801 GDWDVAYGRNARGYLNISRQ SGDAVLPGGQ ALGLNAFSLK TRFQNDRIGI 851 LLDGGARFGR INADLDIGNAFGGNMANAPL GGRITASLPD LGTLKPFLPA 901 AAQNITGSLN AAAQIGGRVG SPSVNAAVNGSSNYGKINGN ITVGQSRSFD 951 TAPLGGRLNL TVADAEVFRN FLPVGQTVKG SLNAAVTLGGSIADPHLGGS 1001 INGDKLYYRN QTQGIILDNG SLRSHIAGRK WVIDSLKFRH EGTAELSGTV1051 GMENSGPDVD IGAVFDKYRI LSRPNRRLTV SGNTRLRYSP QKGISVTGMI 1101KTDQGLFGSQ KSSMPSVGDD VVVLGEVKKE AAAPLPVNMN LTLDLNDGIR 1151 FAGYGADVTIGGKLTLTAQS GGSVRGVGTV RVIKGRYKAY GQDLDITKGT 1201 VSFVGPLNDP NLNIRAERRLSPVGAGVEIL GSLNSPRITL TANEPMSEKD 1251 KLSWLILNRA GSGSSGDNAA LSAAAGALLAGQINDRIGLV DDLGFTSKRS 1301 RNAQTGELNP AEQVLTVGKQ LTGKLYIGYE YSISSAEQSVKLIYRLTRAI 1351 QAVARIGSRS SGGELTYTIR FDRFSGSDKK DSAGNSKGK* m285/a28599.4% identity in 1389 aa overlap        10        20        30        40        50        60 m285.pepMTDTAPTDTDPTENGTRKMPSEHRPTPPAKKRRPLLKLSAALLSVLILAVCFLGWLAGTE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285MTDTAPTDTDPTENGTRKMPSEHRPTPPAKKRRPLLKLSAALLSVLILAVCFLGWLAGTE        10        20        30        40        50        60        70        80        90       100       110       120 m285.pepAGLRFGLYQIPSWFGVNISSQNLKGTLLDGFDGDNWSIETEGADLKISRFRFAWKPSELM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285AGLRFGLYQI PSWFGVNISSQNLKGTLLDGFDGDNWSIETEGADLKISRFRFAWKPSELM        70        80        90       100       110       120       130       140       150       160       170       180 m285.pepRRSLHITEISAGDIAIVTKPTPPKEERPPLSLPDSIDLPAAVYLDRFETGKISMGKAFDK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285RRSLHITEISAGDIAIVTKPTPPKEERPPLSLPDSIDLPAAVYLDRFETGKISMGKAFDK       130       140       150       160       170       180       190       200       210       220       230       240 m285.pepQTVYLERLDASYRYDRKGHRLDLKAADTPWSSSSGAASVGLKKPFALDTAIYTKGGLEGK|||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| a285QTVYLERLDASYRYDRKGHRLDLKAADTPWSSSSGSASVGLKKPFALDTAIYTKGGLEGK       190       200       210       220       230       240       250       260       270       280       290       300 m285.pepTIHSTARLSGSLKDVRAELAIDGGNIRLSGKSVIHPFAESLDKTLEEVLVKGFNINPAAF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| a285TIHSTARLSGSLKDVRAELAIDGGNIRLSGKSVIHPFAESLDKTLEEVLVKGFNINPSAF       250       260       270       280       290       300       310       320       330       340       350       360 m285.pepVPSLPDAGLNFDLTAIPSFSDGIALEGSLDLENTKAGFADRNGIPVRQVLGGFVIRQDGT|||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||| a285VPSLPDAGLNFDLTAIPSFSDGIALEGSLDLENTKAGFADRNGIPVRQVLGSFVIRQDGT       310       320       330       340       350       360       370       380       390       400       410       420 m285.pepVHIGNTSAALLGRGGIRLSGKIDTEKDILDLNIGINSVGAEDVLQTAFKGRLDGSIGIGG|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||| a285VHIGNTSVALLGRGGIRLSGKIDTEKDILDLNIGINSVGAEDVLQTAFKGRLDGSIGIGG       370       380       390       400       410       420       430       440       450       460       470       480 m285.pepTTASPKISWQLGIGTARTDGSLAIASDPANGQRKLVLDTVNIAAGQGSLTAQGYLELFKD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285TTASPKISWQLGIGTARTDGSLAIASDPANGQRKLVLDTVNIAAGQGSLTAQGYLELFKD       430       440       450       460       470       480       490       500       510       520       530       540 m285.pepRLLKLDIRSRAFDPSRIDPQLPAGNINGSINLAGELAKEKFTGKMRFLPGTFNGVPIAGS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285RLLKLDIRSRAFDPSRIDPQLPAGNINGSINLAGELAKEKFTGKMRFLPGTFNGVPIAGS       490       500       510       520       530       540       550       560       570       580       590       600 m285.pepADIVYESRHLPRAAVDLRLGRNIIKTDGGFGKKGDRLNLNITAPDLSRFGFGLAGSLNVR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285ADIVYESRHLPRAAVDLRLGRNIIKIDGGFGKKGDRLNLNITAPDLSRFGFGLAGSLNVR       550       560       570       580       590       600       610       620       630       640       650       660 m285.pepGHLSGDLDGGIRTFETDLSGAARNLHIGKAADIRSLDFTLKGSPDTSRPIRADIKGSRLS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285GHLSGDLDGGIRTFETDLSGAARNLHIGKAADIRSLDFTLKGSPDTSRPIRADIKGSRLS       610       620       630       640       650       660       670       680       690       700       710       720 m285.pepLSGGAAVVDTADLMLDGTGVQHRIRTHAAMTLDGKPFKFDLDASGGINRELTRWKGSIGI||||| |||||||||||||||||||||||||||||||||||||||||||||||||||||| a285LSGGAEVVDTADLMLDGTGVQHRIRTHAAMTLDGKPFKFDLDASGGINRELTRWKGSIGI       670       680       690       700       710       720       730       740       750       760       770       780 m285.pepLDIGGAFNLKLQNRMTLEAGAERVAASAANWQAMGGSLNLQHFSWDKKTGISAKGGAHGL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285LDIGGAFNLKLQNRMTLEAGAERVAASAANWQAMGGSLNLQHFSWDKKTGISAKGGAHGL       730       740       750       760       770       780       790       800       810       820       830       840 m285.pepHIAELHNFFKPPFEHNLVLNGDWDVAYGRNARGYLNISRQSGDAVLPGGQALGLNAFSLK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285HIAELHNFFKPPFEHNLVLNGDWDVAYGRNARGYLNISRQSGDAVLPGGQALGLNAFSLK       790       800       810       820       830       840       850       860       870       880       890       900 m285.pepTRFQNDRIGILLDGGARFGRINADLGIANAFGGNMANAPLGGRITASLPDLGALKPFLPA||||||||||||||||||||||||| |:||||||||||||||||||||||||:||||||| a285TRFQNDRIGILLDGGARFGRINADLDIGNAFGGNMANAPLGGRITASLPDLGTLKPFLPA       850       860       870       880       890       900       910       920       930       940       950       960 m285.pepAAQNITGSLNAAAQIGGRVGSPSVNAAVNGSSNYGKINGNITVGQSRSFDTAPLGGRLNL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285AAQNITGSLNAAAQIGGRVGSPSVNAAVNGSSNYGKINGNITVGQSRSFDTAPLGGRLNL       910       920       930       940       950       960       970       980       990      1000      1010      1020 m285.pepTVADAEVFRNFLPVGQTVKGSLNAAVTLGGSIADPHLGGSINGDKLYYRNQTQGIILDNG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285TVADAEVFRNFLPVGQTVKGSLNAAVTLGGSIADPHLGGSINGDKLYYRNQTQGIILDNG       970       980       990      1000      1010      1020      1030      1040      1050      1060      1070      1080 m285.pepSLRSHIAGRKWVIDSLKFRHEGTAELSGTVGMENSGPDVDIGAVFDKYRILSRPNRRLTV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285SLRSHIAGRKWVIDSLKFRHEGTAELSGTVGMENSGPDVDIGAVFDKYRILSRPNRRLTV      1030      1040      1050      1060      1070      1080      1090      1100      1110      1120      1130      1140 m285.pepSGNTRLRYSPQKGISVTGMIKTDQGLFGSQKSSMPSVGDDVVVLGEVKKEAAAPLPVNMN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285SGNTRLRYSPQKGISVTGMIKTDQGLFGSQKSSMPSVGDDVVVLGEVKKEAAAPLPVNMN      1090      1100      1110      1120      1130      1140      1150      1160      1170      1180      1190      1200 m285.pepLTLDLNDGIRFAGYGADVTIGGKLTLTAQSGGSVRGVGTVRVIKGRYKAYGQDLDITKGT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285LTLDLNDGIRFAGYGADVTIGGKLTLTAQSGGSVRGVGTVRVIKGRYKAYGQDLDITKGT      1150      1160      1170      1180      1190      1200      1210      1220      1230      1240      1250      1260 m285.pepVSFVGPLNDPNLNIRAERRLSPVGAGVEILGSLNSPRITLTANEPMSEKDKLSWLILNRA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285VSFVGPLNDPNLNIRAERRLSPVGAGVEILGSLNSPRITLTANEPMSEKDKLSWLILNRA      1210      1220      1230      1240      1250      1260      1270      1280      1290      1300      1310      1320 m285.pepGSGSSGDNAALSAAAGALLAGQINDRIGLVDDLGFTSKRSRNAQTGELNPAEQVLTVGKQ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285GSGSSGDNAALSAAAGALLAGQINDRIGLVDDLGFTSKRSRNAQTGELNPAEQVLTVGKQ      1270      1280      1290      1300      1310      1320      1330      1340      1350      1360      1370      1380 m285.pepLTGKLYIGYEYSISSAEQSVKLIYRLTRAIQAVARIGSRSSGGELTYTIRFDRFSGSDKK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a285LTGKLYIGYEYSISSAEQSVKLIYRLTRAIQAVARIGSRSSGGELTYTIRFDRFSGSDKK      1330      1340      1350      1360      1370      1380       1390m285.pep DSAGNGKGKX |||||:|||| a285 DSAGNSKGKX       1390The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1187>:

g285-1.seq 1 CTGAAGCTGT CGGCGGCACT GCTGTCTGTC CTGATTTTGG CAGTATGTTT 51CCTCGGCTGG ATCGCCGGTA CGGAAGCAGG TTTGCGCTTC GGGCTGTACC 101 AAATCCCGTCCTGGTTCGGC GTAAACATTT CCTCCCAAAA CCTCAAAGGC 151 ACACTGCTCG ACGGCTTCGACGGCGACAAC TGGTCGATAG AAACCGAGGG 201 GGCAGACCTT AAAATCAGCC GCTTCCGCTTCGCGTGGAAA CCGTCCGAAC 251 TGATGCGCCG CAGCCTGCAC ATCACCGACA TCTCCGCCGGCGACATCGCC 301 ATCGTAACCA AACCGACTCC GCCTAAAGAA GAACGCCCGC CTCAAGGCCT351 GCCCGACAGC ATAGACCTGC CCGCCGCCGT CTATCTCGAC CGCTTCGAGA 401CGGGCAAAAT CAGCATGGGC AAAACCTTTG ACAAACAAAC CGTCTATCTC 451 GAACGCCTCAACGCGGCATA CCGTTACGAC CGTAAAGGGC ACCGCCTCGA 501 CCTGAAGGCC GCCGACACGCCGTGGAGCAG TTCGTCGGGG TCAGCCTCGG 551 TCGGCTTGAA AAAACCGTTT GCCCTCGATACCGCCATTTA CACCAAAGGC 601 GGATTCGAAG GCGAAACCAT ACACAGTACG GCGCGGCTGAGCGGCAGCCT 651 GAAGGATGTG CGCGCCGAAC TGACGATCGA CGGCGGCAAT ATCCGCCTCT701 CGGGAAAATC CGTCATCCAC CCGTTTGCCG AATCATTGGA TAAAACATTG 751GAAGAAGTAC TGGTCAAAGG ATTCAACATC AATCCGTCCG CCTTCGTGCC 801 TTCCCTGCCCGATGCCGGGC TGAATTTCGA CCTGACCGCC ATCCCGTCGT 851 TTTCAGACGG CATCGCGCTGGAAGGCTCGC TCGATTTGGA AAACACCAAA 901 GCCGGCTTTG CCGACCGCAA CGGCATCCCCGTCCGTCAGG TTTTGGGCGG 951 CTTTGTCATC CGGCAGGACG GCACGGTGCA TATCGGCAATACGTCCGCCG 1001 CCCTGCTCGG ACGGGGCGGC ATCAGGCTGT CGGGCAAAAT CGACACCGAA1051 AAAGACATCC TTGATTTAAA TATAGGCATC AACTCCGTCG GCGCGGAAGA 1101CGTGCTGCAA ACCGCGTTCA AAGGCAGGTT GGACGGCAGC ATCGGCATCG 1151 GCGGCACGACCGCCTCGCCC AAAATCTCTT GGCAACTCGG CACCGGCACG 1201 GCACGCACGG ACGGCAGCCtcgcCATCGCA AGCGAcCCCG CAAACGAACA 1251 GCGGAAACTG GTGTTCGACA CCGTCAACATCTCCGCCGGG GAAGGCAGCC 1301 TGACCGCGCA AGGCTATCTC GAGCTGTTTA AAGACCGCCTGCTCAAGCTG 1351 GACATCCGTT CCCGCGCATT CGACCCTTCG CGCATCGATC CGCAATTTCC1401 GGCAGGCgat atCAACGGTT CGATTCATCT TGCCGGTGAA CTGGCAAAAG 1451AGAAATTTAC GGGCAAAATG CGTTTTTTGC CCGGTACGTT CAACGGCGTG 1501 CCGATTGCCGGCAGCGCCGA CATTGTTTAC GAGTCCCGCC ACCTTCCGCG 1551 CGCCGCCGTC GATTTGCGGTTGGGGCGGAA CATCGTCAAA ACAGACGGCG 1601 GCTTCGGCAA AAAAGGCGAC CGGCTTAACCTCAATATCAC CGCACCCGAT 1651 TTATCCCGTT TCGGTTTCGG ACTCGCGGGG TCTTTAAATGTACGCGGACA 1701 CCTTTCCGGC GATTTGGACG GCGGCATCCG AACCTTTGAA ACCGACCTTT1751 CCGGCACGGC GCGCAACTTA CACATCGGCA AAGCGGCAGA CATCCGTTCG 1801CTCGATTTTA CCCTCAAAGG CTCACCCGGC ACAAGCCGCC CGATGCGCGC 1851 CGATATCAAGGGCGGCCGCC TTTCCCTGTC GGGCGGCGCG GCGGTTGTCG 1901 ATACCGCCGG CCTGACGCTGGAAGGTACGG GCGCGCAGCA CCGCATCCGC 1951 ACACACGCCG CCATGACGCT GGACGGCAAACCGTTCAAAC TCGATTTGGA 2001 CGCTTCAGGC GGCATCAACA GGGAACTTAC CCGATGGAAAGGCAGCATCG 2051 GCATCCTCGA CATCGGCGGC GCATTCAACC TCAAGCTGCA AAACCGTATG2101 ACGCTCGAAG CCGGTGCGGA ACACGTGGCG GCAAGTGCGG CAAATTGGCA 2151GGCAATGGGC GGCAGCCTCA ACCTGCAACA CTTTTCTTGG GACAGGAAAA 2201 CCGGCATATCGGCAAAAGGC GGCGCACGCG GCCTGCACAT CGCCGAGTTG 2251 CACAATTTCT TCAAACCGCCCTTCGAACAC AATCTGGTTT TAAACGGCGA 2301 CTGGGATGTC GCCTACGGGC ACAACGCGCGCGGCTACCTC AATATCAGCC 2351 GGCAAAGCGG CGATGCCGTA TTGCCCGGCG GGCAGGCTTTGGGTTTGAAC 2401 GCATTTTCCC TGAAAACGCG CTTTCAAAAC GACCGCATCG GAATCCTGCT2451 TGACGGCGGC GCGCGTTTCG GACGGATTAA CGCCGATTTG GGCATCGGCA 2501ACGCCTTCGG CGGCAATATG GCAAATACAC CGCTCGGCGG CAGGATTACA 2551 GCCTCCCTTCCCGACTTGGG CGCATTGAAG CCCTTTCTGC CCGCCGCCGC 2601 GCAAAACATT ACCGGCAGCCTGAATGCCTC CGCGCAAATC GGCGGACGGG 2651 TAGGCTCTCC GTCCGTCAAT GCCGCCGTCAACGGTAGCAG CAACTACGGG 2701 AAAATCAACG GCAATATCAC CGTCGGGCAA AGCCGCTCCTTCGATACCGC 2751 ACCTTTGGGC GGCAGGCTCA ACCTGACCGT TGCCGATGCC GAAGCATTCC2801 GCAACTTCCT ACCGGTCGGA CAAACCGTCA AAGGCAGCCT GAATGCCGCC 2851GTAACCCTCG GCGGCAGCAT CGCCGACCCG CACTTGGGCG GCAGTATCAA 2901 CGGCGACAAGCTCTATTACC GCAACCAAAC CCAAGGCATC ATCTTGGACA 2951 ACGGCTCGCT GCGTTCGCATATTGCAGGCA GGAAATGGGT AATCGACAGC 3001 CTGAAATTCC GGCACGAAGG GACGGCGGAACTCTCCGGCA CGGTCAGCAT 3051 GGAAAACAGC GTGCCCGATG TCGATATCGG CGCGGTGTTCGACAAATACC 3101 GCATCCTGTC CCGCCCCAAC CGCCGCCTGA CGGTTTCCGG CAACACCCGC3151 CTGCGCTATT CGCCGCAAAA AGGCATATCC GTTACCGGTA TGATTAAAAC 3201TGATCAGGGG CTGTTCGGTT CGCAAAAATC CTCGATGCCG TCCGTCGGCG 3251 ACGATGTCGTCGTATTGGGC GAAGTCAAGA AAGAGGCGGC GGCATCGCTC 3301 CCCGTCAATA TGAACCTGACTTTAGACCTC AATGACGGCA TCCGCTTCTC 3351 CGGCTACGGC GCGGACGTTA CCATAGGCGGCAAACTGACC CTGACCGCGC 3401 AACCGGGCGG AAATGTGCGT GGGGTGGGCA CGGTCCGCGTCATCAAAGGG 3451 CGTTACAAAG CATACGGGCA GGATTTAGAC ATTACCAAAG GCACAGTCTC3501 CTTTGTCGGC CCGCTCAACG ACCCCAACCT GAACATCCGC GCCGAACGCC 3551GCCTTTCCCC CGTCGGTGCG GGCGTGGAAA TATTGGGCAG CCTCAACAGC 3601 CCGCGCATTACGCTGACGGC AAACGAACCG ATGAGTGAAA AAGACAAGCT 3651 CTCCTGGCTC ATCCTCAACCGTGCCGGCAG CGGCAGCAGC GGCGACAATG 3701 CCGCCCTGTC CGCAGCCGCA GGCGCGCTGCTTGCCGGGCA AATCAACGAC 3751 CGCATCGGGC TGGTGGATGA TTTGGGCTTT ACCAGCAAGCGCAGCCGCAA 3801 CGCGCAAACC GGCGAACTCA ACCCCGCCGA ACAGGTGCTG ACCGTCGGCA3851 AACAACTGAC CGGCAAACTC TACATCGGCT ACGAATACGG CATCTCCAGC 3901GCGGAACAGT CCGTCAAACT GATTTACCGG CTGACCCGCG CCATACAGGC 3951 GGTTGCCCGTATCGGCAGCC GTTCGTCGGG CGGCGAGCTG ACATACACCA 4001 TACGTTTCGA CCGCCTCTTCGGTTCGGACA AAAAAGACTC CGCAGGAAAC 4051 GGCAAAGGGA AATAAThis corresponds to the amino acid sequence <SEQ ID 1188; ORF 285-1.ng>:

g285-1.pep 1 LKLSAALLSV LILAVCFLGW IAGTEAGLRF GLYQIPSWFG VNISSQNLKG 51TLLDGFDGDN WSIETEGADL KISRFRFAWK PSELMRRSLH ITDISAGDIA 101 IVTKPTPPKEERPPQGLPDS IDLPAAVYLD RFETGKISMG KTFDKQTVYL 151 ERLNAAYRYD RKGHRLDLKAADTPWSSSSG SASVGLKKPF ALDTAIYTKG 201 GFEGETIHST ARLSGSLKDV RAELTIDGGNIRLSGKSVIH PFAESLDKTL 251 EEVLVKGFNI NPSAFVPSLP DAGLNFDLTA IPSFSDGIALEGSLDLENTK 301 AGFADRNGIP VRQVLGGFVI RQDGTVHIGN TSAALLGRGG IRLSGKIDTE351 KDILDLNIGI NSVGAEDVLQ TAFKGRLDGS IGIGGTTASP KISWQLGTGT 401ARTDGSLAIA SDPANEQRKL VFDTVNISAG EGSLTAQGYL ELFKDRLLKL 451 DIRSRAFDPSRIDPQFPAGD INGSIHLAGE LAKEKFTGKM RFLPGTFNGV 501 PIAGSADIVY ESRHLPRAAVDLRLGRNIVK TDGGFGKKGD RLNLNITAPD 551 LSRFGFGLAG SLNVRGHLSG DLDGGIRTFETDLSGTARNL HIGKAADIRS 601 LDFTLKGSPG TSRPMRADIK GGRLSLSGGA AVVDTAGLTLEGTGAQHRIR 651 THAAMTLDGK PFKLDLDASG GINRELTRWK GSIGILDIGG AFNLKLQNRM701 TLEAGAEHVA ASAANWQAMG GSLNLQHFSW DRKTGISAKG GARGLHIAEL 751HNFFKPPFEH NLVLNGDWDV AYGHNARGYL NISRQSGDAV LPGGQALGLN 801 AFSLKTRFQNDRIGILLDGG ARFGRINADL GIGNAFGGNM ANTPLGGRIT 851 ASLPDLGALK PFLPAAAQNITGSLNASAQI GGRVGSPSVN AAVNGSSNYG 901 KINGNITVGQ SRSFDTAPLG GRLNLTVADAEAFRNFLPVG QTVKGSLNAA 951 VTLGGSIADP HLGGSINGDK LYYRNQTQGI ILDNGSLRSHIAGRKWVIDS 1001 LKFRHEGTAE LSGTVSMENS VPDVDIGAVF DKYRILSRPN RRLTVSGNTR1051 LRYSPQKGIS VTGMIKTDQG LFGSQKSSMP SVGDDVVVLG EVKKEAAASL 1101PVNMNLTLDL NDGIRFSGYG ADVTIGGKLT LTAQPGGNVR GVGTVRVIKG 1151 RYKAYGQDLDITKGTVSFVG PLNDPNLNIR AERRLSPVGA GVEILGSLNS 1201 PRITLTANEP MSEKDKLSWLILNRAGSGSS GDNAALSAAA GALLAGQIND 1251 RIGLVDDLGF TSKRSRNAQT GELNPAEQVLTVGKQLTGKL YIGYEYGISS 1301 AEQSVKLIYR LTRAIQAVAR IGSRSSGGEL TYTIRFDRLFGSDKKDSAGN 1351 GKGK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1189>:

m285-1.seq 1 CTGAAGCTGT CGGCGGCACT GCTGTCTGTC CTGATTTTGG CAGTATGTTT 51CCTCGGCTGG CTCGCCGGTA CGGAAGCAGG TTTGCGCTTC GGGCTGTACC 101 AAATCCCGTCTTGGTTCGGC GTAAACATTT CCTCCCAAAA CCTCAAAGGC 151 ACGCTGCTCG ACGGCTTCGACGGCGACAAC TGGTCGATAG AAACCGAGGG 201 GGCAGACCTT AAAATCAGCC GCTTCCGCTTCGCGTGGAAA CCGTCCGAAC 251 TGATGCGCCG CAGCCTGCAC ATTACCGAAA TTTCCGCCGGCGACATCGCC 301 ATCGTTACCA AACCGACTCC GCCTAAAGAA GAACGCCCGC CGCTCAGCCT351 TCCCGACAGC ATAGACCTGC CTGCCGCCGT CTATCTCGAC CGCTTCGAGA 401CGGGCAAAAT CAGCATGGGC AAAGCCTTTG ACAAACAAAC CGTCTATCTC 451 GAACGGCTGGATGCTTCATA CCGTTACGAC CGCAAAGGAC ACCGCCTTGA 501 CCTGAAGGCC GCCGACACGCCGTGGAGCAG TTCGTCGGGG GCGGCCTCGG 551 TCGGCTTGAA AAAACCGTTT GCCCTCGATACCGCCATTTA CACCAAAGGC 601 GGACTCGAAG GCAAAACCAT ACACAGTACG GCTCGGCTGAGCGGCAGCCT 651 GAAGGATGTG CGCGCCGAAC TGGCGATCGA CGGCGGCAAT ATCCGCCTCT701 CGGGAAAATC CGTCATCCAC CCGTTTGCCG AATCATTGGA TAAAACATTG 751GAAGAAGTAC TGGTCAAAGG GTTCAACATC AATCCGGCCG CCTTCGTGCC 801 TTCCCTGCCCGATGCCGGAC TGAATTTCGA CCTGACCGCC ATCCCGTCGT 851 TTTCAGACGG CATCGCGCTGGAAGGTTCGC TCGATTTGGA AAACACCAAA 901 GCCGGCTTTG CCGACCGCAA CGGCATCCCCGTCCGTCAGG TTTTAGGCGG 951 CTTTGTCATC CGGCAGGACG GCACGGTGCA TATCGGCAATACGTCCGCCG 1001 CCCTGCTCGG ACGGGGCGGC ATCAGGCTGT CGGGCAAAAT CGACACCGAA1051 AAAGACATCC TCGATTTAAA TATAGGCATC AACTCCGTCG GCGCGGAAGA 1101CGTACTGCAA ACCGCGTTCA AAGGCAGGTT GGACGGCAGC ATCGGCATCG 1151 GTGGCACGACCGCCTCGCCC AAAATCTCTT GGCAACTCGG CATCGGCACG 1201 GCGCGCACGG ACGGCAGCCTCGCCATTGCA AGCGACCCAG CAAACGGACA 1251 GCGGAAACTG GTGCTCGACA CCGTCAACATCGCCGCCGGG CAAGGCAGCC 1301 TGACCGCGCA AGGCTATCTC GAGCTGTTTA AAGACCGCCTGCTCAAGCTG 1351 GACATCCGTT CCCGCGCATT CGACCCTTCG CGCATCGATC CGCAACTTCC1401 GGCAGGCAAT ATCAACGGCT CAATAAACCT TGCCGGCGAA CTGGCAAAAG 1451AGAAATTCAC AGGCAAAATG CGGTTTTTAC CCGGCACGTT CAACGGCGTA 1501 CCGATTGCCGGCAGTGCCGA CATTGTTTAC GAGTCCCGCC ACCTTCCGCG 1551 TGCCGCCGTC GATTTGCGGCTGGGGCGGAA CATTATTAAA ACAGACGGCG 1601 GCTTCGGCAA AAAAGGCGAC CGGCTTAACCTCAATATCAC CGCACCCGAT 1651 TTATCCCGTT TCGGTTTCGG ACTCGCGGGG TCTTTAAATGTACGCGGACA 1701 CCTTTCCGGT GATTTGGACG GCGGCATCCG AACCTTTGAA ACCGACCTTT1751 CCGGCGCGGC GCGCAACCTG CACATCGGCA AGGCGGCAGA CATCCGTTCG 1801CTCGATTTCA CGCTCAAAGG TTCGCCCGAC ACAAGCCGCC CGATACGCGC 1851 CGACATCAAAGGCAGCCGCC TTTCGCTGTC GGGCGGAGCG GCGGTTGTCG 1901 ATACCGCCGA CCTGATGCTGGACGGCACGG GCGTGCAGCA CCGCATCCGC 1951 ACACACGCCG CCATGACGCT GGATGGCAAACCGTTCAAAT TCGATTTGGA 2001 CGCTTCAGGC GGCATCAACA GGGAACTTAC CCGATGGAAAGGCAGCATCG 2051 GCATCCTCGA CATCGGCGGC GCATTCAACC TCAAGCTGCA AAACCGTATG2101 ACGCTCGAAG CCGGTGCGGA ACGCGTGGCG GCAAGTGCGG CAAATTGGCA 2151GGCAATGGGC GGCAGCCTCA ACCTGCAACA CTTTTCTTGG GATAAAAAAA 2201 CCGGCATATCGGCAAAAGGC GGCGCACACG GTCTGCATAT CGCCGAGTTG 2251 CACAATTTCT TCAAACCGCCCTTCGAACAC AATCTGGTTT TAAACGGCGA 2301 CTGGGATGTC GCCTACGGGC GCAACGCGCGCGGCTACCTC AATATCAGCC 2351 GGCAAAGCGG CGATGCCGTA TTGCCCGGCG GGCAGGCTTTGGGTTTGAAC 2401 GCATTTTCCC TGAAAACGCG CTTTCAAAAC GACCGCATCG GAATCCTGCT2451 TGACGGCGGC GCGCGTTTCG GGCGGATTAA CGCCGATTTG GGCATCGCCA 2501ACGCCTTCGG CGGCAATATG GCAAATGCAC CGCTCGGCGG CAGGATTACC 2551 GCCTCCCTTCCCGACTTGGG CGCATTGAAG CCCTTTCTGC CCGCCGCCGC 2601 GCAAAACATT ACCGGCAGCCTGAATGCCGC CGCGCAAATC GGCGGACGGG 2651 TAGGCTCTCC GTCCGTCAAT GCCGCCGTCAACGGCAGCAG CAACTACGGG 2701 AAAATCAACG GCAACATCAC CGTCGGGCAA AGCCGCTCTTTCGATACCGC 2751 GCCTTTGGGC GGCAGGCTCA ACCTGACCGT TGCCGATGCC GAAGTATTCC2801 GCAACTTCCT ACCGGTCGGA CAAACCGTCA AAGGCAGCCT GAATGCCGCC 2851GTAACCCTCG GCGGCAGCAT CGCCGATCCG CACTTGGGCG GCAGCATCAA 2901 CGGCGACAAACTCTATTACC GCAACCAAAC CCAAGGCATC ATCTTGGACA 2951 ACGGCTCGCT GCGTTCGCATATCGCGGGCA GGAAATGGGT AATCGACAGC 3001 CTGAAATTCC GGCACGAAGG GACGGCGGAACTCTCCGGTA CGGTCGGTAT 3051 GGAAAACAGC GGACCCGATG TCGATATCGG CGCGGTGTTCGACAAATACC 3101 GCATCCTGTC CCGCCCCAAC CGCCGCCTGA CGGTTTCCGG CAACACCCGC3151 CTGCGCTATT CGCCGCAAAA AGGCATATCC GTTACCGGGA TGATTAAAAC 3201GGATCAGGGG CTGTTCGGTT CGCAAAAATC CTCGATGCCG TCCGTCGGCG 3251 ACGATGTCGTCGTATTAGGC GAAGTCAAAA AAGAGGCGGC GGCACCGCTC 3301 CCCGTCAATA TGAACCTGACTTTAGACCTC AATGACGGCA TCCGCTTCGC 3351 CGGCTACGGC GCGGACGTTA CCATAGGCGGCAAACTGACC CTGACCGCCC 3401 AATCGGGCGG AAGCGTACGG GGCGTGGGCA CGGTCCGCGTCATCAAAGGG 3451 CGTTATAAGG CATACGGGCA GGATTTGGAC ATTACCAAAG GCACGGTCTC3501 CTTTGTCGGC CCGCTCAACG ATCCCAACCT CAACATCCGC GCCGAACGCC 3551GCCTTTCCCC CGTCGGTGCG GGCGTGGAAA TATTGGGCAG CCTCAACAGC 3601 CCGCGCATTACGCTGACGGC AAACGAACCG ATGAGTGAAA AAGACAAGCT 3651 CTCTTGGCTC ATCCTCAACCGCGCCGGCAG CGGCAGCAGC GGCGACAATG 3701 CCGCCCTGTC TGCAGCCGCA GGTGCGCTGCTTGCCGGGCA AATCAACGAC 3751 CGCATCGGGC TGGTGGATGA TTTGGGCTTT ACCAGCAAGCGCAGCCGCAA 3801 CGCGCAAACC GGCGAACTCA ACCCCGCCGA ACAGGTGCTG ACCGTCGGCA3851 AACAACTGAC CGGCAAACTC TACATCGGCT ACGAATACAG CATCTCCAGC 3901GCGGAACAGT CCGTCAAACT GATTTACCGG CTGACCCGCG CCATACAGGC 3951 GGTTGCCCGTATCGGCAGCC GTTCGTCGGG CGGCGAGCTG ACATACACCA 4001 TACGTTTCGA CCGCTTCTCCGGTTCGGACA AAAAAGACTC CGCCGGAAAC 4051 GGCAAAGGAA AATAAThis corresponds to the amino acid sequence <SEQ ID 1190; ORF 285-1>:

m285-1.pep 1 LKLSAALLSV LILAVCFLGW LAGTEAGLRF GLYQIPSWFG VNISSQNLKG 51TLLDGFDGDN WSIETEGADL KISRFRFAWK PSELMRRSLH ITEISAGDIA 101 IVTKPTPPKEERPPLSLPDS IDLPAAVYLD RFETGKISMG KAFDKQTVYL 151 ERLDASYRYD RKGHRLDLKAADTPWSSSSG AASVGLKKPF ALDTAIYTKG 201 GLEGKTIHST ARLSGSLKDV RAELAIDGGNIRLSGKSVIH PFAESLDKTL 251 EEVLVKGFNI NPAAFVPSLP DAGLNFDLTA IPSFSDGIALEGSLDLENTK 301 AGFADRNGIP VRQVLGGFVI RQDGTVHIGN TSAALLGRGG IRLSGKIDTE351 KDILDLNIGI NSVGAEDVLQ TAFKGRLDGS IGIGGTTASP KISWQLGIGT 401ARTDGSLAIA SDPANGQRKL VLDTVNIAAG QGSLTAQGYL ELFKDRLLKL 451 DIRSRAFDPSRIDPQLPAGN INGSINLAGE LAKEKFTGKM RFLPGTFNGV 501 PIAGSADIVY ESRHLPRAAVDLRLGRNIIK TDGGFGKKGD RLNLNITAPD 551 LSRFGFGLAG SLNVRGHLSG DLDGGIRTFETDLSGAARNL HIGKAADIRS 601 LDFTLKGSPD TSRPIRADIK GSRLSLSGGA AVVDTADLMLDGTGVQHRIR 651 THAAMTLDGK PFKFDLDASG GINRELTRWK GSIGILDIGG AFNLKLQNRM701 TLEAGAERVA ASAANWQAMG GSLNLQHFSW DKKTGISAKG GAHGLHIAEL 751HNFFKPPFEH NLVLNGDWDV AYGRNARGYL NISRQSGDAV LPGGQALGLN 801 AFSLKTRFQNDRIGILLDGG ARFGRINADL GIANAFGGNM ANAPLGGRIT 851 ASLPDLGALK PFLPAAAQNITGSLNAAAQI GGRVGSPSVN AAVNGSSNYG 901 KINGNITVGQ SRSFDTAPLG GRLNLTVADAEVFRNFLPVG QTVKGSLNAA 951 VTLGGSIADP HLGGSINGDK LYYRNQTQGI ILDNGSLRSHIAGRKWVIDS 1001 LKFRHEGTAE LSGTVGMENS GPDVDIGAVF DKYRILSRPN RRLTVSGNTR1051 LRYSPQKGIS VTGMIKTDQG LFGSQKSSMP SVGDDVVVLG EVKKEAAAPL 1101PVNMNLTLDL NDGIRFAGYG ADVTIGGKLT LTAQSGGSVR GVGTVRVIKG 1151 RYKAYGQDLDITKGTVSFVG PLNDPNLNIR AERRLSPVGA GVEILGSLNS 1201 PRITLTANEP MSEKDKLSWLILNRAGSGSS GDNAALSAAA GALLAGQIND 1251 RIGLVDDLGF TSKRSRNAQT GELNPAEQVLTVGKQLTGKL YIGYEYSISS 1301 AEQSVKLIYR LTRAIQAVAR IGSRSSGGEL TYTIRFDRFSGSDKKDSAGN 1351 GKGK* g285-1/m285-1 96.5% identity in 1354 aa overlap        10        20        30        40        50        60 g285-1.pepLKLSAALLSVLILAVCFLGWIAGTEAGLRFGLYQIPSWFGVNISSQNLKGTLLDGFDGDN||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||| m285-1LKLSAALLSVLILAVCFLGWLAGTEAGLRFGLYQIPSWFGVNISSQNLKGTLLDGFDGDN        10        20        30        40        50        60        70        80        90       100       110       120 g285-1.pepWSIETEGADLKISRFRFAWKPSELMRRSLHITDISAGDIAIVTKPTPPKEERPPQGLPDS||||||||||||||||||||||||||||||||:||||||||||||||||||||| :|||| m285-1WSIETEGADLKISRFRFAWKPSELMRRSLHITEISAGDIAIVTKPTPPKEERPPLSLPDS        70        80        90       100       110       120       130       140       150       160       170       180 g285-1.pepIDLPAAVYLDRFETGKISMGKTFDKQTVYLERLNAAYRYDRKGHRLDLKAADTPWSSSSG|||||||||||||||||||||:|||||||||||:|:|||||||||||||||||||||||| m285-1IDLPAAVYLDRFETGKISMGKAFDKQTVYLERLDASYRYDRKGHRLDLKAADTPWSSSSG       130       140       150       160       170       180       190       200       210       220       230       240 g285-1.pepSASVGLKKPFALDTAIYTKGGFEGETIHSTARLSGSLKDVRAELTIDGGNIRLSGKSVIH:||||||||||||||||||||:||:|||||||||||||||||||:||||||||||||||| m285-1AASVGLKKPFALDTAIYTKGGLEGKTIHSTARLSGSLKDVRAELAIDGGNIRLSGKSVIH       190       200       210       220       230       240       250       260       270       280       290       300 g285-1.pepPFAESLDKTLEEVLVKGFNINPSAFVPSLPDAGLNFDLTAIPSFSDGIALEGSLDLENTK||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||| m285-1PFAESLDKTLEEVLVKGFNINPAAFVPSLPDAGLNFDLTAIPSFSDGIALEGSLDLENTK       250       260       270       280       290       300       310       320       330       340       350       360 g285-1.pepAGFADRNGIPVRQVLGGFVIRQDGTVHIGNTSAALLGRGGIRLSGKIDTEKDILDLNIGI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1AGFADRNGIPVRQVLGGFVIRQDGTVHIGNTSAALLGRGGIRLSGKIDTEKDILDLNIGI       310       320       330       340       350       360       370       380       390       400       410       420 g285-1.pepNSVGAEDVLQTAFKGRLDGSIGIGGTTASPKISWQLGTGTARTDGSLAIASDPANEQRKL||||||||||||||||||||||||||||||||||||| ||||||||||||||||| |||| m285-1NSVGAEDVLQTAFKGRLDGSIGIGGTTASPKISWQLGIGTARTDGSLAIASDPANGQRKL       370       380       390       400       410       420       430       440       450       460       470       480 g285-1.pepVFDTVNISAGEGSLTAQGYLELFKDRLLKLDIRSRAFDPSRIDPQFPAGDINGSIHLAGE|:|||||:||:||||||||||||||||||||||||||||||||||:|||:|||||:|||| m285-1VLDTVNIAAGQGSLTAQGYLELFKDRLLKLDIRSRAFDPSRIDPQLPAGNINGSINLAGE       430       440       450       460       470       480       490       500       510       520       530       540 g285-1.pepLAKEKFTGKMRFLPGTFNGVPIAGSADIVYESRHLPRAAVDLRLGRNIVKLDGGFGKKGD||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||| m285-1LAKEKFTGKMRFLPGTFNGVPIAGSADIVYESRHLPRAAVDLRLGRNIIKTDGGFGKKGD       490       500       510       520       530       540       550       560       570       580       590       600 g285-1.pepRLNLNITAPDLSRFGFGLAGSLNVRGHLSGDLDGGIRTFELDLSGTARNLHIGKAADIRS|||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||| m285-1RLNLNITAPDLSRFGFGLAGSLNVRGHLSGDLDGGIRTFELDLSGAARNLHIGKAADIRS       550       560       570       580       590       600       610       620       630       640       650       660 g285-1.pepLDFTLKGSPGTSRPMRADIKGGRLSLSGGAAVVDTAGLTLEGTGAQHRIRTHAAMTLDGK||||||||| ||||:||||||:|||||||||||||| | |:|||:||||||||||||||| m285-1LDFTLKGSPDTSRPIRADIKGSRLSLSGGAAVVDTADLMLDGTGVQHRIRTHAAMTLDGK       610       620       630       640       650       660       670       680       690       700       710       720 g285-1.pepPFKLDLDASGGINRELTRWKGSIGILDIGGAFNLKLQNRMTLEAGAEHVAASAANWQAMG|||:|||||||||||||||||||||||||||||||||||||||||||:|||||||||||| m285-1PFKFDLDASGGINRELTRWKGSIGILDIGGAFNLKLQNRMTLEAGAERVAASAANWQAMG       670       680       690       700       710       720       730       740       750       760       770       780 g285-1.pepGSLNLQHFSWDRKTGISAKGGARGLHIAELHNFFKPPFEHNLVLNGDWDVAYGHNARGYL|||||||||||:||||||||||:||||||||||||||||||||||||||||||:|||||| m285-1GSLNLQHFSWDKKTGISAKGGAHGLHIAELHNFFKPPFEHNLVLNGDWDVAYGRNARGYL       730       740       750       760       770       780       790       800       810       820       830       840 g285-1.pepNISRQSGDAVLPGGQALGLNAFSLKTRFQNDRIGILLDGGARFGRINADLGIGNAFGGNM||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||| m285-1NISRQSGDAVLPGGQALGLNAFSLKTRFQNDRIGILLDGGARFGRINADLGIANAFGGNM       790       800       810       820       830       840       850       860       870       880       890       900 g285-1.pepANTPLGGRITASLPDLGALKPFLPAAAQNITGSLNASAQIGGRVGSPSVNAAVNGSSNYG||:|||||||||||||||||||||||||||||||||:||||||||||||||||||||||| m285-1ANAPLGGRITASLPDLGALKPFLPAAAQNITGSLNAAAQIGGRVGSPSVNAAVNGSSNYG       850       860       870       880       890       900       910       920       930       940       950       960 g285-1.pepKINGNITVGQSRSFDTAPLGGRLNLTVADAEAFRNFLPVGQTVKGSLNAAVTLGGSIADP|||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||| m285-1KINGNITVGQSRSFDTAPLGGRLNLTVADAEVERNFLPVGQTVKGSLNAAVTLGGSIADP       910       920       930       940       950       960       970       980       990      1000      1010      1020 g285-1.pepHLGGSINGDKLYYRNQTQGIILDNGSLRSHIAGRKWVIDSLKFRHEGTAELSGTVSMENS|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||| m285-1HLGGSINGDKLYYRNQTQGIILDNGSLRSHIAGRKWVIDSLKFRHEGTAELSGTVGMENS       970       980       990      1000      1010      1020      1030      1040      1050      1060      1070      1080 g285-1.pepVPDVDIGAVFDKYRILSRPNRRLTVSGNTRLRYSPQKGISVTGMIKTDQGLFGSQKSSMP ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1GPDVDIGAVFDKYRILSRPNRRLTVSGNTRLRYSPQKGISVTGMIKTDQGLFGSQKSSMP      1030      1040      1050      1060      1070      1080      1090      1100      1110      1120      1130      1140 g285-1.pepSVGDDVVVLGEVKKEAAASLPVNMNLTLDLNDGIRFSGYGADVTIGGKLTLTAQPGGNVR|||||||||||||||||| |||||||||||||||||:||||||||||||||||| ||:|| m285-1SVGDDVVVLGEVKKEAAAPLPVNMNLTLDLNDGIRFAGYGADVTIGGKLTLTAQSGGSVR      1090      1100      1110      1120      1130      1140      1150      1160      1170      1180      1190      1200 g285-1.pepGVGTVRVIKGRYKAYGQDLDITKGTVSFVGPLNDPNLNIRAERRLSPVGAGVEILGSLNS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1GVGTVRVIKGRYKAYGQDLDITKGTVSFVGPLNDPNLNIRAERRLSPVGAGVEILGSLNS      1150      1160      1170      1180      1190      1200      1210      1220      1230      1240      1250      1260 g285-1.pepPRITLTANEPMSEKDKLSWLILNRAGSGSSGDNAALSAAAGALLAGQINDRIGLVDDLGF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1PRITLTANEPMSEKDKLSWLILNRAGSGSSGDNAALSAAAGALLAGQINDRIGLVDDLGF      1210      1220      1230      1240      1250      1260      1270      1280      1290      1300      1310      1320 g285-1.pepTSKRSRNAQTGELNPAEQVLTVGKQLTGKLYIGYEYGISSAEQSVKLIYRLTRAIQAVAR||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||| m285-1TSKRSRNAQTGELNPAEQVLTVGKQLTGKLYIGYEYSISSAEQSVKLIYRLTRAIQAVAR      1270      1280      1290      1300      1310      1320      1330      1340      1350 g285-1.pepIGSRSSGGELTYTIRFDRLFGSDKKDSAGNGKGK ||||||||||||||||||: ||||||||||||||m285-1 IGSRSSGGELTYTIRFDRFSGSDKKDSAGNGKGKX      1330      1340      1350The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1191>:

a285-1.seq 1 CTGAAGCTGT CGGCGGCACT GCTGTCTGTT CTGATTTTGG CAGTATGTTT 51CCTCGGCTGG CTCGCCGGCA CGGAAGCGGG TTTGCGCTTC GGGCTGTACC 101 AAATCCCGTCTTGGTTCGGC GTAAACATTT CCTCCCAAAA CCTCAAAGGC 151 ACGCTGCTCG ACGGCTTCGACGGCGACAAC TGGTCGATAG AAACCGAGGG 201 GGCAGACCTT AAAATCAGCC GCTTCCGCTTCGCGTGGAAA CCGTCCGAAC 251 TGATGCGCCG CAGCCTGCAC ATTACCGAAA TTTCCGCCGGCGACATCGCC 301 ATCGTTACCA AACCGACTCC GCCTAAAGAA GAACGCCCGC CGCTCAGCCT351 TCCCGACAGC ATAGACCTGC CTGCCGCCGT CTATCTCGAC CGCTTCGAGA 401CGGGCAAAAT CAGCATGGGC AAAGCCTTTG ACAAACAAAC CGTCTATCTC 451 GAACGGCTGGATGCTTCATA CCGTTACGAC CGCAAAGGAC ACCGCCTCGA 501 CCTGAAGGCT GCCGACACGCCGTGGAGCAG TTCGTCGGGG TCAGCCTCGG 551 TCGGCTTGAA AAAACCGTTT GCCCTCGATACCGCCATTTA CACCAAAGGC 601 GGACTCGAAG GCAAAACCAT ACACAGTACG GCTCGGCTGAGCGGCAGCCT 651 GAAGGATGTG CGCGCCGAAC TGGCGATCGA CGGCGGCAAT ATCCGCCTCT701 CGGGAAAATC CGTCATCCAC CCGTTTGCCG AATCATTGGA TAAAACATTG 751GAAGAAGTAC TGGTCAAAGG GTTCAACATC AATCCGTCCG CCTTCGTGCC 801 TTCCCTGCCCGATGCCGGGC TGAATTTCGA CCTGACCGCC ATCCCGTCGT 851 TTTCAGACGG CATCGCGCTGGAAGGCTCGC TCGATTTGGA AAACACCAAA 901 GCCGGCTTTG CCGACCGCAA CGGCATCCCCGTCCGTCAGG TTTTAGGCAG 951 CTTTGTCATC CGGCAGGACG GCACGGTGCA TATCGGCAATACGTCCGTCG 1001 CCCTGCTCGG ACGGGGCGGC ATCAGGCTGT CGGGCAAAAT CGACACCGAA1051 AAAGACATCC TCGATTTAAA TATAGGCATC AACTCCGTCG GCGCGGAAGA 1101CGTACTGCAA ACCGCGTTCA AAGGCAGGTT GGACGGCAGC ATCGGCATCG 1151 GTGGCACGACCGCCTCGCCC AAAATCTCTT GGCAACTCGG CATCGGCACG 1201 GCGCGCACGG ACGGCAGCCTCGCCATTGCA AGCGACCCCG CAAACGGACA 1251 GCGGAAACTG GTGCTCGACA CCGTCAACATCGCCGCCGGG CAAGGCAGCC 1301 TGACCGCGCA AGGCTATCTC GAGCTGTTTA AAGACCGCCTGCTCAAGCTG 1351 GACATCCGTT CCCGCGCATT CGACCCTTCG CGCATCGATC CGCAACTTCC1401 GGCAGGCAAT ATCAACGGCT CAATAAACCT TGCCGGCGAA CTGGCAAAAG 1451AGAAATTCAC AGGCAAAATG CGGTTTTTAC CCGGCACGTT CAACGGCGTA 1501 CCGATTGCCGGCAGTGCCGA CATTGTTTAC GAGTCCCGCC ACCTTCCGCG 1551 TGCCGCCGTC GATTTGCGGCTGGGGCGGAA CATTATTAAA ACAGACGGCG 1601 GCTTCGGCAA AAAAGGCGAC CGGCTTAACCTCAATATCAC CGCACCCGAT 1651 TTATCCCGTT TCGGTTTCGG ACTCGCGGGG TCTTTAAATGTACGCGGACA 1701 CCTTTCCGGC GATTTGGACG GTGGCATCCG AACCTTTGAA ACCGACCTTT1751 CCGGCGCGGC GCGCAACCTG CACATCGGCA AGGCGGCAGA CATCCGTTCG 1801CTCGATTTCA CGCTCAAAGG TTCGCCCGAC ACAAGCCGCC CGATACGCGC 1851 CGACATCAAAGGCAGCCGCC TTTCGCTGTC GGGCGGAGCG GAGGTTGTCG 1901 ATACCGCCGA CCTGATGCTGGACGGCACGG GCGTGCAGCA CCGCATCCGC 1951 ACACACGCCG CCATGACGCT GGATGGCAAACCGTTCAAAT TCGATTTGGA 2001 CGCTTCAGGC GGCATCAACA GGGAACTTAC CCGATGGAAAGGCAGCATCG 2051 GCATCCTCGA CATCGGCGGC GCATTCAACC TCAAGCTGCA AAACCGTATG2101 ACGCTCGAAG CCGGTGCGGA ACGCGTGGCG GCAAGTGCGG CAAATTGGCA 2151GGCAATGGGC GGCAGCCTCA ACCTGCAACA CTTTTCTTGG GATAAAAAAA 2201 CCGGCATATCGGCAAAAGGC GGCGCACACG GTCTGCATAT CGCCGAGTTG 2251 CACAATTTCT TCAAACCGCCCTTCGAACAC AATCTGGTTT TAAACGGCGA 2301 CTGGGATGTC GCCTACGGGC GAAACGCGCGCGGCTACCTC AATATCAGCC 2351 GGCAAAGCGG CGATGCCGTA TTGCCCGGCG GGCAGGCTTTGGGTTTGAAC 2401 GCATTTTCCC TGAAAACGCG CTTTCAAAAC GACCGTATCG GAATCCTGCT2451 TGACGGCGGC GCGCGTTTCG GGCGGATTAA CGCCGATTTG GACATCGGCA 2501ACGCCTTCGG CGGCAATATG GCAAATGCAC CGCTCGGCGG CAGGATTACC 2551 GCCTCCCTTCCCGACTTGGG CACATTGAAG CCCTTTCTGC CCGCCGCCGC 2601 GCAAAACATT ACCGGCAGCCTGAATGCCGC CGCGCAAATC GGCGGACGGG 2651 TCGGCTCTCC GTCCGTCAAT GCCGCCGTCAACGGCAGCAG CAACTACGGG 2701 AAAATCAACG GCAACATCAC CGTCGGGCAA AGCCGCTCTTTCGATACCGC 2751 GCCTTTGGGC GGCAGGCTCA ACCTGACCGT TGCCGATGCC GAAGTATTCC2801 GCAACTTCCT ACCGGTCGGA CAAACCGTCA AAGGCAGCCT GAATGCCGCC 2851GTAACCCTCG GCGGCAGCAT CGCCGATCCG CACTTGGGCG GCAGCATCAA 2901 CGGCGACAAACTCTATTACC GCAACCAAAC CCAAGGCATC ATCTTGGACA 2951 ACGGCTCGCT GCGTTCGCATATCGCGGGCA GGAAATGGGT AATCGACAGC 3001 CTGAAATTCC GGCACGAAGG GACGGCGGAACTCTCCGGTA CGGTCGGTAT 3051 GGAAAACAGC GGACCCGATG TCGATATCGG CGCGGTGTTCGACAAATACC 3101 GCATCCTGTC CCGCCCCAAC CGCCGCCTGA CGGTTTCCGG CAACACCCGC3151 CTGCGCTATT CGCCGCAAAA AGGCATATCC GTTACCGGGA TGATTAAAAC 3201GGATCAGGGG CTGTTCGGTT CGCAAAAATC CTCGATGCCG TCCGTCGGCG 3251 ACGATGTCGTCGTATTAGGC GAAGTCAAAA AAGAGGCGGC GGCACCGCTC 3301 CCCGTCAATA TGAACCTGACTTTAGACCTC AATGACGGCA TCCGCTTCGC 3351 CGGCTACGGC GCGGACGTTA CCATAGGCGGCAAACTGACC CTGACCGCCC 3401 AATCGGGCGG AAGCGTGCGG GGCGTGGGCA CGGTCCGCGTCATCAAAGGG 3451 CGTTATAAGG CATACGGGCA GGATTTGGAC ATTACCAAAG GCACGGTCTC3501 CTTTGTCGGC CCGCTCAACG ACCCCAACCT CAACATCCGC GCCGAACGCC 3551GCCTTTCCCC CGTCGGTGCG GGCGTGGAAA TATTGGGCAG CCTCAACAGT 3601 CCGCGCATTACGCTGACGGC AAACGAACCG ATGAGTGAAA AAGACAAGCT 3651 CTCCTGGCTC ATCCTCAACCGCGCCGGCAG TGGCAGCAGC GGCGACAATG 3701 CCGCCCTGTC CGCAGCCGCC GGCGCGCTGCTTGCCGGGCA AATCAACGAC 3751 CGCATCGGGC TGGTGGATGA TTTGGGCTTT ACCAGCAAGCGCAGCCGCAA 3801 CGCGCAAACC GGCGAACTCA ACCCCGCCGA ACAGGTGCTG ACCGTCGGCA3851 AACAACTGAC CGGCAAACTC TACATCGGCT ACGAATACAG CATCTCCAGC 3901GCGGAACAGT CCGTCAAACT GATTTACCGG CTGACCCGCG CCATACAGGC 3951 GGTTGCCCGTATCGGCAGCC GTTCGTCGGG CGGCGAGCTG ACATACACCA 4001 TACGTTTCGA CCGCTTCTCCGGTTCGGACA AAAAAGACTC CGCCGGAAAC 4051 AGCAAAGGAA AATAAThis corresponds to the amino acid sequence <SEQ ID 1192; ORF 285-1.a>:

a285-1.pep 1 LKLSAALLSV LILAVCFLGW LAGTEAGLRF GLYQIPSWFG VNISSQNLKG 51TLLDGFDGDN WSIETEGADL KISRFRFAWK PSELMRRSLH ITEISAGDIA 101 IVTKPTPPKEERPPLSLPDS IDLPAAVYLD RFETGKISMG KAFDKQTVYL 151 ERLDASYRYD RKGHRLDLKAADTPWSSSSG SASVGLKKPF ALDTAIYTKG 201 GLEGKTIHST ARLSGSLKDV RAELAIDGGNIRLSGKSVIH PFAESLDKTL 251 EEVLVKGFNI NPSAFVPSLP DAGLNFDLTA IPSFSDGIALEGSLDLENTK 301 AGFADRNGIP VRQVLGSFVI RQDGTVHIGN TSVALLGRGG IRLSGKIDTE351 KDILDLNIGI NSVGAEDVLQ TAFKGRLDGS IGIGGTTASP KISWQLGIGT 401ARTDGSLAIA SDPANGQRKL VLDTVNIAAG QGSLTAQGYL ELFKDRLLKL 451 DIRSRAFDPSRIDPQLPAGN INGSINLAGE LAKEKFTGKM RFLPGTFNGV 501 PIAGSADIVY ESRHLPRAAVDLRLGRNIIK TDGGFGKKGD RLNLNITAPD 551 LSRFGFGLAG SLNVRGHLSG DLDGGIRTFETDLSGAARNL HIGKAADIRS 601 LDFTLKGSPD TSRPIRADIK GSRLSLSGGA EVVDTADLMLDGTGVQHRIR 651 THAAMTLDGK PFKFDLDASG GINRELTRWK GSIGILDIGG AFNLKLQNRM701 TLEAGAERVA ASAANWQAMG GSLNLQHFSW DKKTGISAKG GAHGLHIAEL 751HNFFKPPFEH NLVLNGDWDV AYGRNARGYL NISRQSGDAV LPGGQALGLN 801 AFSLKTRFQNDRIGILLDGG ARFGRINADL DIGNAFGGNM ANAPLGGRIT 851 ASLPDLGTLK PFLPAAAQNITGSLNAAAQI GGRVGSPSVN AAVNGSSNYG 901 KINGNITVGQ SRSFDTAPLG GRLNLTVADAEVFRNFLPVG QTVKGSLNAA 951 VTLGGSIADP HLGGSINGDK LYYRNQTQGI ILDNGSLRSHIAGRKWVIDS 1001 LKFRHEGTAE LSGTVGMENS GPDVDIGAVF DKYRILSRPN RRLTVSGNTR1051 LRYSPQKGIS VTGMIKTDQG LFGSQKSSMP SVGDDVVVLG EVKKEAAAPL 1101PVNMNLTLDL NDGIRFAGYG ADVTIGGKLT LTAQSGGSVR GVGTVRVIKG 1151 RYKAYGQDLDITKGTVSFVG PLNDPNLNIR AERRLSPVGA GVEILGSLNS 1201 PRITLTANEP MSEKDKLSWLILNRAGSGSS GDNAALSAAA GALLAGQIND 1251 RIGLVDDLGF TSKRSRNAQT GELNPAEQVLTVGKQLTGKL YIGYEYSISS 1301 AEQSVKLIYR LTRAIQAVAR IGSRSSGGEL TYTIRFDRFSGSDKKDSAGN 1351 SKGK* a285-1/m285-1 99.3% identity in 1354 aa overlap        10        20        30        40        50        60 a285-1.pepLKLSAALLSVLILAVCFLGWLAGTEAGLRFGLYQIPSWFGVNISSQNLKGTLLDGFDGDN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1LKLSAALLSVLILAVCFLGWLAGTEAGLRFGLYQIPSWFGVNISSQNLKGTLLDGFDGDN        10        20        30        40        50        60        70        80        90       100       110       120 a285-1.pepWSIETEGADLKISRFRFAWKPSELMRRSLHITEISAGDIAIVTKPTPPKEERPPLSLPDS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1WSIETEGADLKISRFRFAWKPSELMRRSLHITEISAGDIAIVTKPTPPKEERPPLSLPDS        70        80        90       100       110       120       130       140       150       160       170       180 a285-1.pepIDLPAAVYLDRFETGKISMGKAFDKQTVYLERLDASYRYDRKGHRLDLKAADTPWSSSSG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1IDLPAAVYLDRFETGKISMGKAFDKQTVYLERLDASYRYDRKGHRLDLKAADTPWSSSSG       130       140       150       160       170       180       190       200       210       220       230       240 a285-1.pepSASVGLKKPFALDTAIYTKGGLEGKTIHSTARLSGSLKDVRAELAIDGGNIRLSGKSVIH:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1AASVGLKKPFALDTAIYTKGGLEGKTIHSTARLSGSLKDVRAELAIDGGNIRLSGKSVIH       190       200       210       220       230       240       250       260       270       280       290       300 a285-1.pepPFAESLDKTLEEVLVKGFNINPSAFVPSLPDAGLNFDLTAIPSFSDGIALEGSLDLENTK||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||| m285-1PFAESLDKTLEEVLVKGFNINPAAFVPSLPDAGLNFDLTAIPSFSDGIALEGSLDLENTK       250       260       270       280       290       300       310       320       330       340       350       360 a285-1.pepAGFADRNGIPVRQVLGSFVIRQDGTVHIGNTSVALLGRGGIRLSGKIDTEKDILDLNIGI||||||||||||||||:|||||||||||||||:||||||||||||||||||||||||||| m285-1AGFADRNGIPVRQVLGGFVIRQDGTVHIGNTSAALLGRGGIRLSGKIDTEKDILDLNIGI       310       320       330       340       350       360       370       380       390       400       410       420 a285-1.pepNSVGAEDVLQTAFKGRLDGSIGIGGTTASPKISWQLGIGTARTDGSLAIASDPANGQRKL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1NSVGAEDVLQTAFKGRLDGSIGIGGTTASPKISWQLGIGTARTDGSLAIASDPANGQRKL       370       380       390       400       410       420       430       440       450       460       470       480 a285-1.pepVLDTVNIAAGQGSLTAQGYLELFKDRLLKLDIRSRAFDPSRIDPQLPAGNINGSINLAGE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1VLDTVNIAAGQGSLTAQGYLELFKDRLLKLDIRSRAFDPSRIDPQLPAGNINGSINLAGE       430       440       450       460       470       480       490       500       510       520       530       540 a285-1.pepLAKEKFTGKMRFLPGTFNGVPIAGSADIVYESRHLPRAAVDLRLGRNIIKTDGGFGKKGD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1LAKEKFTGKMRFLPGTFNGVPIAGSADIVYESRHLPRAAVDLRLGRNIIKTDGGFGKKGD       490       500       510       520       530       540       550       560       570       580       590       600 a285-1.pepRLNLNITAPDLSRFGFGLAGSLNVRGHLSGDLDGGIRTFELDLSGAARNLHIGKAADIRS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1RLNLNITAPDLSRFGFGLAGSLNVRGHLSGDLDGGIRTFELDLSGAARNLHIGKAADIRS       550       560       570       580       590       600       610       620       630       640       650       660 a285-1.pepLDFTLKGSPDTSRPIRADIKGSRLSLSGGAEVVDTADLMLDGTGVQHRIRTHAAMTLDGK|||||||||||||||||||||||||||||| ||||||||||||||||||||||||||||| m285-1LDFTLKGSPDTSRPIRADIKGSRLSLSGGAAVVDTADLMLDGTGVQHRIRTHAAMTLDGK       610       620       630       640       650       660       670       680       690       700       710       720 a285-1.pepPFKFDLDASGGINRELTRWKGSIGILDIGGAFNLKLQNRMTLEAGAERVAASAANWQAMG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1PFKFDLDASGGINRELTRWKGSIGILDIGGAFNLKLQNRMTLEAGAERVAASAANWQAMG       670       680       690       700       710       720       730       740       750       760       770       780 a285-1.pepGSLNLQHFSWDKKTGISAKGGAHGLHIAELHNFFKPPFEHNLVLNGDWDVAYGRNARGYL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1GSLNLQHFSWDKKTGISAKGGAHGLHIAELHNFFKPPFEHNLVLNGDWDVAYGRNARGYL       730       740       750       760       770       780       790       800       810       820       830       840 a285-1.pepNISRQSGDAVLPGGQALGLNAFSLKTRFQNDRIGILLDGGARFGRINADLDIGNAFGGNM|||||||||||||||||||||||||||||||||||||||||||||||||| |:||||||| m285-1NISRQSGDAVLPGGQALGLNAFSLKTRFQNDRIGILLDGGARFGRINADLGIANAFGGNM       790       800       810       820       830       840       850       860       870       880       890       900 a285-1.pepANAPLGGRITASLPDLGTLKPFLPAAAQNITGSLNAAAQIGGRVGSPSVNAAVNGSSNYG|||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||| m285-1ANAPLGGRITASLPDLGALKPFLPAAAQNITGSLNAAAQIGGRVGSPSVNAAVNGSSNYG       850       860       870       880       890       900       910       920       930       940       950       960 a285-1.pepKINGNITVGQSRSFDTAPLGGRLNLTVADAEVFRNFLPVGQTVKGSLNAAVTLGGSIADP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1KINGNITVGQSRSFDTAPLGGRLNLTVADAEVFRNFLPVGQTVKGSLNAAVTLGGSIADP       910       920       930       940       950       960       970       980       990      1000      1010      1020 a285-1.pepHLGGSINGDKLYYRNQTQGIILDNGSLRSHIAGRKWVIDSLKFRHEGTAELSGTVGMENS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1HLGGSINGDKLYYRNQTQGIILDNGSLRSHIAGRKWVIDSLKFRHEGTAELSGTVGMENS       970       980       990      1000      1010      1020      1030      1040      1050      1060      1070      1080 a285-1.pepGPDVDIGAVFDKYRILSRPNRRLTVSGNTRLRYSPQKGISVTGMIKTDQGLFGSQKSSMP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1GPDVDIGAVFDKYRILSRPNRRLTVSGNTRLRYSPQKGISVTGMIKTDQGLFGSQKSSMP      1030      1040      1050      1060      1070      1080      1090      1100      1110      1120      1130      1140 a285-1.pepSVGDDVVVLGEVKKEAAAPLPVNMNLTLDLNDGIRFAGYGADVTIGGKLTLTAQSGGSVR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1SVGDDVVVLGEVKKEAAAPLPVNMNLTLDLNDGIRFAGYGADVTIGGKLTLTAQSGGSVR      1090      1100      1110      1120      1130      1140      1150      1160      1170      1180      1190      1200 a285-1.pepGVGTVRVIKGRYKAYGQDLDITKGTVSFVGPLNDPNLNIRAERRLSPVGAGVEILGSLNS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1GVGTVRVIKGRYKAYGQDLDITKGTVSFVGPLNDPNLNIRAERRLSPVGAGVEILGSLNS      1150      1160      1170      1180      1190      1200      1210      1220      1230      1240      1250      1260 a285-1.pepPRITLTANEPMSEKDKLSWLILNRAGSGSSGDNAALSAAAGALLAGQINDRIGLVDDLGF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1PRITLTANEPMSEKDKLSWLILNRAGSGSSGDNAALSAAAGALLAGQINDRIGLVDDLGF      1210      1220      1230      1240      1250      1260      1270      1280      1290      1300      1310      1320 a285-1.pepTSKRSRNAQTGELNPAEQVLTVGKQLTGKLYIGYEYSISSAEQSVKLIYRLTRAIQAVAR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m285-1TSKRSRNAQTGELNPAEQVLTVGKQLTGKLYIGYEYSISSAEQSVKLIYRLTRAIQAVAR      1270      1280      1290      1300      1310      1320      1330      1340      1350 a285-1.pepIGSRSSGGELTYTIRFDRFSGSDKKDSAGNSKGKX ||||||||||||||||||||||||||||||:||||m285-1 IGSRSSGGELTYTIRFDRFSGSDKKDSAGNGKGKX      1330      1340      1350The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1193>:

g286.seq 1 atgcagaaca ccggtaccat gatgatcaaa ccgaccgccc tgctcctgcc 51ggctttattt ttctttccgc acgcatacgc gcctgccgcc gacctttccg 101 aaaacaaggcggcgggtttc gcattgttca aaagcaaaag ccccgacacc 151 gaatcagtca aattaaaacccaaattcccc gtccgcatcg acacgcagga 201 cagtgaaatc aaagatatgg tcgaagaacacctgccgctc atcacgcagc 251 agcaggaaga ggttttggat aaggaacaga cgggattccttgccgaagaa 301 gcaccggaca acgttaaaac aatgctccgc agcaaaggct atttcagcag351 caaggtcagc ctgacggaaa aagacggagc ttatacggtg cacatcacac 401cgggcccgcg caccaaaatc gccaacgtcg gcgtcgccat cctcggcgac 451 atcctttcagacggcaacct cgccgaatac taccgcaacg cgctggaaaa 501 ctggcagcag ccggtaggcagcgatttcga tcaggacagt tgggaaaaca 551 gcaaaacttc cgtcctcggc gcggtaacgcgcaaaggcta cccgcttgcc 601 aagctcggca acacccgggc ggccgtcaac cccgataccgccaccgccga 651 tttgaacgtc gtcgtggaca gcggccgccc cattgccttc ggcgactttg701 aaatcaccgg cacacagcgt taccccgaac aaaccgtctc cggcctggcg 751cgcttccaac cgggcacgcc ctacgacctc gacctgctgc tcgacttcca 801 acaggcgctcgaacaaaacg ggcattattc cggcgcgtcc gtacaagccg 851 acttcgaccg cctcccaaggggaccgcgtc cccgtcaaag tcagcgtaac 901 cgaggtcaaa cgccacaaac tcgaaaccggcatccgcctc gattcggaat 951 acggtttggg cggcaaaatc gcctacgact attacaacctcttcaacaaa 1001 ggctatatcg gctcggtcgt ctgggatatg gacaaatacg aaaccacgct1051 tgccgccggc atcagccagc cgcgcaacta tcggggcaac tactggacaa 1101gcaacgtttc ctacaaccgt tcgaccaccc aaaacctcga aaaacgcgcc 1151 ttctccggcggcatctggta tgtgcgcgac cgcgcgggca tcgatgccag 1201 gctgggggcg gaatttctcgcagaaggccg gaaaatcccc ggctcggatg 1251 tcgatttggg caacagccac gccacgatgctgaccgcctc ttggaaacgc 1301 cagctgctca acaacgtgct gcaccccgaa aacggccattacctcgacgg 1351 caaaatcggg acgactttgg gcacattcct gtcctccacc gcgctaatcc1401 gcacctctgc ccgcgcaggt tatttcttca cgcccgaaaa caaaaaactc 1451ggcacgttca tcatacgcgg acaagcgggt tacaccgttg cacgcgacaa 1501 tgccgatgtcccctcggggc tgatgttccg cagcggcggc gcgtcttccg 1551 tgcgcggtta cgaacttgaThis corresponds to the amino acid sequence <SEQ ID 1194; ORF 286.ng>:

g286.pep 1 MQNTGTMMIK PTALLLPALF FFPHAYAPAA DLSENKAAGF ALFKSKSPDT 51ESVKLKPKFP VRIDTQDSEI KDMVEEHLPL ITQQQEEVLD KEQTGFLAEE 101 APDNVKTMLRSKGYFSSKVS LTEKDGAYTV HITPGPRTKI ANVGVAILGD 151 ILSDGNLAEY YRNALENWQQPVGSDFDQDS WENSKTSVLG AVTRKGYPLA 201 KLGNTRAAVN PDTATADLNV VVDSGRPIAFGDFEITGTQR YPEQTVSGLA 251 RFQPGTPYDL DLLLDFQQAL EQNGHYSGAS VQADFDRLPRGPRPRQSQRN 301 RGQTPQTRNR HPPRFGIRFG RQNRLRLLQP LQQRLYRLGR LGYGQIRNHA351 CRRHQPAAQL SGQLLDKQRF LQPFDHPKPR KTRLLRRHLV CARPRGHRCQ 401AGGGISRRRP ENPRLGCRFG QQPRHDADRL LETPAAQQRA APRKRPLPRR 451 QNRDDFGHIPVLHRANPHLC PRRLFLHARK QKTRHVHHTR TSGLHRCTRQ 501 CRCPLGADVP QRRRVFRARLRT*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1195>:

m286.seq 1 ATGCACGACA CCCGTACCAT GATGATCAAA CCGACCGCCC TGCTCCTGCC 51GGCTTTATTT TTCTTTCCGC ACGCATACGC GCCTGCCGCC GACCTTTCCG 101 AAAACAAGGCGGCGGGTTTC GCATTGTTCA AAAACAAAAG CCCCGACACC 151 GAATCAGTCA AATTAAAACCCAAATTCCCC GTCCTCATCG ACACGCAGGA 201 CAGTGAAATC AAAGATATGG TCGAAGAACACCTGCCGCTC ATCACGCAGC 251 AGCAGGAAGA AGTATTGGAC AAGGAACAGA CGGGCTTCCTCGCCGAAGAA 301 GCGCCGGACA ACGTTAAAAC GATGCTCCGC AGCAAAGGCT ATTTCAGCAG351 CAAAGTCAGC CTGACGGAAA AAGACGGAGC TTATACGGTA CACATCACAC 401CGGGCCCGCG CACCAAAATC GCCAACGTCG GCGTCGCCAT CCTCGGCGAC 451 ATCCTTTCAGACGGCAACCT CGCCGAATAC TACCGCAACG CGCTGGAAAA 501 CTGGCAGCAG CCGGTAGGCAGCGATTTCGA TCAGGACAGT TGGGAAAACA 551 GCAAAACTTC CGTCCTCGGC GCGGTAACGCGCAAAGCCTA CCCGCTTGCC 601 AAGCTCGGCA ATACGCAGGC GGCCGTCAAC CCCGATACCGCCACCGCCGA 651 TTTGAACGTC GTCGTGGACA GCGGCCGCCC CATCGCCTTC GGCGACTTTG701 AAATCACCGG CACACAGCGT TACCCCGAAC AAATCGTCTC CGGCCTTGCG 751CGTTTCCAGC CCGGTATGCC GTACGACCTC GACCTGCTGC TCGACTTCCA 801 ACAGGCGCTCGAACAAAACG GGCATTATTC CGGCGCGTCC GTACAAGCCG 851 ACTTCGACCG CCTCCAAGGCGACCGCGTCC CCGTCAAAGT CAGCGTAACC 901 GAGGTCAAAC GCCACAAACT CGAAACCGGCATCCGCCTCG ATTCGGAATA 951 CGGTTTGGGC GGCAAAATCG CCTACGACTA TTACAACCTCTTCAACAAAG 1001 GCTATATCGG TTCGGTCGTC TGGGATATGG ACAAATACGA AACCACGCTT1051 GCCGCCGGCA TCAGCCAGCC GCGCAACTAT CGGGGCAACT ACTGGACAAG 1101CAACGTTTCC TACAACCGTT CGACCACCCA AAACCTCGAA AAACGCGCCT 1151 TCTCCGGCGGCGTCTGGTAT GTGCGCGACC GCGCGGGCAT CGATGCCAGG 1201 CTGGGGGCGG AATTTCTCGCAGAAGGCCGG AAAATCCCCG GCTCGGCTGT 1251 CGATTTGGGC AACAGCCACG CCACGATGCTGACCGCCTCT TGGAAACGCC 1301 AGCTGCTCAA CAACGTGCTG CATCCCGAAA ACGGCCATTACCTCGACGGC 1351 AAAATCGGTA CGACTTTGGG CACATTCCTG TCCTCCACCG CGCTGATCCG1401 CACCTCTGCC CGTGCAGGTT ATTTCTTCAC GCCCGAAAAC AAAAAACTCG 1451GCACGTTCAT CATACGCGGA CAAGCGGGTT ACACCGTTGC CCGCGACAAT 1501 GCCGACGTTCCTTCAGGGCT GATGTTCCGC AGCGGCGGCG CGTCTTCCGT 1551 GCGCGGTTAC GAACTCGACAGCATCGGACT TGCCGGCCCG AACGGATCGG 1601 TCCTGCCCGA ACGCGCCCTC CTGGTGGGCAGCCTGGAATA CCAACTGCCG 1651 TTTACGCGCA CCCTTTCCGG CGCGGTGTTC CACGATATGGGCGATGCCGC 1701 CGCCAATTTC AAACGTATGA AGCTGAAACA CGGTTCGGGA CTGGGCGTGC1751 GCTGGTTCAG CCCGCTTGCG CCGTTTTCCT TCGACATCGC CTACGGGCAC 1801AGCGATAAGA AAATCCGCTG GCACATCAGC TTGGGAACGC GCTTCTAAThis corresponds to the amino acid sequence <SEQ ID 1196; ORF 286>:

m286.pep 1 MHDTRTMMIK PTALLLPALF FFPHAYAPAA DLSENKAAGF ALFKNKSPDT 51ESVKLKPKFP VLIDTQDSEI KDMVEEHLPL ITQQQEEVLD KEQTGFLAEE 101 APDNVKTMLRSKGYFSSKVS LTEKDGAYTV HITPGPRTKI ANVGVAILGD 151 ILSDGNLAEY YRNALENWQQPVGSDFDQDS WENSKTSVLG AVTRKAYPLA 201 KLGNTQAAVN PDTATADLNV VVDSGRPIAFGDFEITGTQR YPEQIVSGLA 251 RFQPGMPYDL DLLLDFQQAL EQNGHYSGAS VQADFDRLQGDRVPVKVSVT 301 EVKRHKLETG IRLDSEYGLG GKIAYDYYNL FNKGYIGSVV WDMDKYETTL351 AAGISQPRNY RGNYWTSNVS YNRSTTQNLE KRAFSGGVWY VRDRAGIDAR 401LGAEFLAEGR KIPGSAVDLG NSHATMLTAS WKRQLLNNVL HPENGHYLDG 451 KIGTTLGTFLSSTALIRTSA RAGYFFTPEN KKLGTFIIRG QAGYTVARDN 501 ADVPSGLMFR SGGASSVRGYELDSIGLAGP NGSVLPERAL LVGSLEYQLP 551 FTRTLSGAVF HDMGDAAANF KRMKLKHGSGLGVRWFSPLA PFSFDIAYGH 601 SDKKIRWHIS LGTRF*Computer analysis of this amino acid sequence gave the followingresults:

m286/g286 95.9% identity in 293 aa overlap          10        20        30        40        50        60 m286.pep  MHDTRTMMIKPTALLLPALFFFPHAYAPAADLSENKAAGFALFKNKSPDTESVKLKPKFP  |::| |||||||||||||||||||||||||||||||||||||||:||||||||||||||| g286  MQNTGTMMIKPTALLLPALFFFPHAYAPAADLSENKAAGFALFKSKSPDTESVKLKPKFP          10        20        30        40        50        60          70        80        90       100       110       120 m286.pep  VLIDTQDSEIKDMVEEHLPLITQQQEEVLDKEQTGFLAEEAPDNVKTMLRSKGYFSSKVS  | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g286  VRIDTQDSEIKDMVEEHLPLITQQQEEVLDKEQTGFLAEEAPDNVKTMLRSKGYFSSKVS          70        80        90       100       110       120         130       140       150       160       170       180 m286.pep  LTEKDGAYTVHITPGPRTKIANVGVAILGDILSDGNLAEYYRNALENWQQPVGSDFDQDS  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g286  LTEKDGAYTVHITPGPRTKIANVGVAILGDILSDGNLAEYYRNALENWQQPVGSDFDQDS         130       140       150       160       170       180         190       200       210       220       230       240 m286.pep  WENSKTSVLGAVTRKAYPLAKLGNTQAAVNPDTATADLNVVVDSGRPIAFGDFEITGTQR  |||||||||||||||:|||||||||:|||||||||||||||||||||||||||||||||| g286  WENSKTSVLGAVTRKGYPLAKLGNTRAAVNPDTATADLNVVVDSGRPIAFGDFEITGTQR         190       200       210       220       230       240         250       260       270       280        290      299 m286.pep  YPEQIVSGLARFQPGMPYDLDLLLDFQQALEQNGHYSGASVQADFDRL-QGDRVPVKVSV  |||| |||||||||| |||||||||||||||||||||||||||||||| :| | g286  YPEQTVSGLARFQPGTPYDLDLLLDFQQALEQNGHYSGASVQADFDRLPRGPRPRQSQRN         250       260       270       280       290       300300       310       320       330       340       350      359 m286.pep  TEVKRHKLETGIRLDSEYGLGGKIAYDYYNLFNKGYIGSVVWDMDKYETTLAAGISQPRN g286  RGQTPQTRNRHPPRFGIRFGRQNRLRLLQPLQQRLYRLGRLGYGQIRNHACRRHQPAAQL         310       320       330       340       350       360The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1197>:

a286.seq 1 ATGCACGACA CCCGTACCAT GATGATTAAA CCGACCGCCC TGCTCCTGCC 51GGCTTTATTT TTCTTTCCGC ACGCATACGC GCCTGCCGCC GACCTTTCCG 101 AAAACAAGGCGGCGGGTTTC GCATTGTTCA AAAACAAAAG CCCCGACACC 151 GAATCAGTTA AATTAAAACCCAAATTCCCC GTCCGCATCG ACACGCAGGA 201 TAGTGAAATC AAAGATATGG TCGAAGAACACCTGCCGCTC ATCACGCAGC 251 AGCAGGAAGA AGTATTGGAC AAGGAACAGA CGGGCTTCCTCGCCGAAGAA 301 GCACCGGACA ACGTTAAAAC AATGCTCCGC AGCAAAGGCT ATTTCAGCAG351 CAAAGTCAGC CTGACGGAAA AAGACGGAGC TTATACGGTA CACATCACAC 401CGGGCCCGCG CACCAAAATC GCCAACGTCG GCGTCGCCAT CCTCGGCGAC 451 ATCCTTTCAGACGGCAACCT CGCCGAATAC TACCGCAACG CGCTGGAAAA 501 CTGGCAGCAG CCGGTAGGCAGTGATTTCGA TCAGGACAGT TGGGAAAACA 551 GCAAAACTTC CGTCCTCGGC GCGGTAACGCGCAAAGCCTA CCCGCTTGCC 601 AAGCTCGGCA ACACCCGGGC GGCCGTCAAC CCCGATACCGCCACCGCCGA 651 TTTGAACGTC GTCGTGGACA GCGGCCGCCC CATCGCCTTC GGCGACTTTG701 AAATTACCGG CACGCAGCGT TACCCCGAAC AAATCGTCTC CGGCTTGGCG 751CGCTTCCAAC CGGGCACGCC CTACGACCTC GACCTGCTGC TCGACTTCCA 801 ACAGGCGCTCGAACAAAACG GGCATTATTC CGGCGCGTCC GTACAAGCCG 851 ACTTCGACCG CCTCCAAGGCGACCGCGTCC CCGTCAAAGT CAGCGTAACC 901 GAGGTCAAAC GCCACAAGCT CGAAACCGGCATCCGCCTCG ATTCGGAATA 951 CGGTTTGGGC GGCAAAATCG CCTACGACTA TTACAACCTCTTCAACAAAG 1001 GCTATATCGG TTCGGTCGTC TGGGATATGG ACAAATACGA AACCACGCTT1051 GCCGCCGGCA TCAGCCAGCC GCGCAACTAT CGGGGCAACT ACTGGACAAG 1101CAACGTTTCC TACAACCGTT CGACCACCCA AAACCTCGAA AAACGCGCCT 1151 TCTCCGGCGGCATCTGGTAT GTGCGCGACC GCGCGGGCAT CGATGCCAGG 1201 CTGGGGGCGG AGTTTCTCGCAGAAGGCCGG AAAATCCCCG GCTCGGATAT 1251 CGATTTGGGC AACAGCCACG CCACGATGCTGACCGCCTCT TGGAAACGCC 1301 AGCTGCTCAA CAACGTGCTG CATCCCGAAA ACGGCCATTACCTCGACGGC 1351 AAAATCGGTA CGACTTTGGG CGCATTCCTG TCCTCCACCG CGCTGATCCG1401 CACCTCTGCC CGCGCAGGTT ATTTCTTCAC GCCCGAAAAC AAAAAACTCG 1451GCACGTTCAT CATACGCGGA CAAGCGGGTT ACACCGTTGC CCGCGACAAT 1501 GCCAACGTTCCTTCAGGGCT GATGTTCCGC AGCGGCGGCG CGTCTTCCGT 1551 GCGCGGTTAC GAACTCGACAGCATCGGGCT TGCCGGCCCG AACGGATCGG 1601 TCCTGCCCGA ACGCGCCCTC TTGGTGGGCAGCCTGGAATA CCAACTGCCG 1651 TTTACGCGCA CCCTTTCCGG CGCGGTGTTC CACGATATGGGCGACGCCGC 1701 CGCCAATTTC AAACGTATGA AGCTGAAACA CGGTTCGGGA CTGGGCGTGC1751 GCTGGTTCAG CCCGCTCGCG CCGTTTTCCT TCGACATCGC CTACGGGCAC 1801AGCGACAAGA AAATCCGCTG GCACATCAGC TTGGGAACGC GCTTCTAAThis corresponds to the amino acid sequence <SEQ ID 1198; ORF 286.a>:

a286.pep 1 MHDTRTMMIK PTALLLPALF FFPHAYAPAA DLSENKAAGF ALFKNKSPDT 51ESVKLKPKFP VRIDTQDSEI KDMVEEHLPL ITQQQEEVLD KEQTGFLAEE 101 APDNVKTMLRSKGYFSSKVS LTEKDGAYTV HITPGPRTKI ANVGVAILGD 151 ILSDGNLAEY YRNALENWQQPVGSDFDQDS WENSKTSVLG AVTRKAYPLA 201 KLGNTRAAVN PDTATADLNV VVDSGRPIAFGDFEITGTQR YPEQIVSGLA 251 RFQPGTPYDL DLLLDFQQAL EQNGHYSGAS VQADFDRLQGDRVPVKVSVT 301 EVKRHKLETG IRLDSEYGLG GKIAYDYYNL FNKGYIGSVV WDMDKYETTL351 AAGISQPRNY RGNYWTSNVS YNRSTTQNLE KRAFSGGIWY VRDRAGIDAR 401LGAEFLAEGR KIPGSDIDLG NSHATMLTAS WKRQLLNNVL HPENGHYLDG 451 KIGTTLGAFLSSTALIRTSA RAGYFFTPEN KKLGTFIIRG QAGYTVARDN 501 ANVPSGLMFR SGGASSVRGYELDSIGLAGP NGSVLPERAL LVGSLEYQLP 551 FTRTLSGAVF HDMGDAAANF KRMKLKHGSGLGVRWFSPLA PFSFDIAYGH 601 SDKKIRWHIS LGTRF* m286/a286 98.7% identity in615 aa overlap        10        20        30        40        50        60 m286.pepMHDTRTMMIKPTALLLPALFFFPHAYAPAADLSENKAAGFALFKNKSPDTESVKLKPKFP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a286MHDTRTMMIKPTALLLPALFFFPHAYAPAADLSENKAAGFALFKNKSPDTESVKLKPKFP        10        20        30        40        50        60        70        80        90       100       110       120 m286.pepVLIDTQDSEIKDMVEEHLPLITQQQEEVLDKEQTGFLAEEAPDNVKTMLRSKGYFSSKVS| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a286VRIDTQDSEIKDMVEEHLPLITQQQEEVLDKEQTGFLAEEAPDNVKTMLRSKGYFSSKVS        70        80        90       100       110       120       130       140       150       160       170       180 m286.pepLTEKDGAYTVHITPGPRTKIANVGVAILGDILSDGNLAEYYRNALENWQQPVGSDFDQDS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a286LTEKDGAYTVHITPGPRTKIANVGVAILGDILSDGNLAEYYRNALENWQQPVGSDFDQDS       130       140       150       160       170       180       190       200       210       220       230       240 m286.pepWENSKTSVLGAVTRKAYPLAKLGNTQAAVNPDTATADLNVVVDSGRPIAFGDFEITGTQR|||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||| a286WENSKTSVLGAVTRKAYPLAKLGNTRAAVNPDTATADLNVVVDSGRPIAFGDFEITGTQR       190       200       210       220       230       240       250       260       270       280       290       300 m286.pepYPEQIVSGLARFQPGMPYDLDLLLDFQQALEQNGHYSGASVQADFDRLQGDRVPVKVSVT||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| a286YPEQIVSGLARFQPGTPYDLDLLLDFQQALEQNGHYSGASVQADFDRLQGDRVPVKVSVT       250       260       270       280       290       300       310       320       330       340       350       360 m286.pepEVKRHKLETGIRLDSEYGLGGKIAYDYYNLFNKGYIGSVVWDMDKYETTLAAGISQPRNY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a286EVKRHKLETGIRLDSEYGLGGKIAYDYYNLFNKGYIGSVVWDMDKYETTLAAGISQPRNY       310       320       330       340       350       360       370       380       390       400       410       420 m286.pepRGNYWTSNVSYNRSTTQNLEKRAFSGGVWYVRDRAGIDARLGAEFLAEGRKIPGSAVDLG|||||||||||||||||||||||||||:||||||||||||||||||||||||||| :||| a286RGNYWTSNVSYNRSTTQNLEKRAFSGGIWYVRDRAGIDARLGAEFLAEGRKIPGSDIDLG       370       380       390       400       410       420       430       440       450       460       470       480 m286.pepNSHATMLTASWKRQLLNNVLHPENGHYLDGKIGTTLGTFLSSTALIRTSARAGYFFTPEN|||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||| a286NSHATMLTASWKRQLLNNVLHPENGHYLDGKIGTTLGAFLSSTALIRTSARAGYFFTPEN       430       440       450       460       470       480       490       500       510       520       530       540 m286.pepKKLGTFIIRGQAGYTVARDNADVPSGLMFRSGGASSVRGYELDSIGLAGPNGSVLPERAL|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| a286KKLGTFIIRGQAGYTVARDNANVPSGLMFRSGGASSVRGYELDSIGLAGPNGSVLPERAL       490       500       510       520       530       540       550       560       570       580       590       600 m286.pepLVGSLEYQLPFTRTLSGAVFHDMGDAAANFKRMKLKHGSGLGVRWFSPLAPFSFDIAYGH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a286LVGSLEYQLPFTRTLSGAVFHDMGDAAANFKRMKLKHGSGLGVRWFSPLAPFSFDIAYGH       550       560       570       580       590       600        610m286.pep SDKKIRWHISLGTRFX |||||||||||||||| a286 SDKKIRWHISLGTRFX       610The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1199>:

g287.seq 1 atgtttaaac gcagtgtgat tgcaatggct tgtatttttc ccctttcagc 51ctgtgggggc ggcggtggcg gatcgcccga tgtcaagtcg gcggacacgc 101 cgtcaaaaccggccgccccc gttgttgctg aaaatgccgg ggaaggggtg 151 ctgccgaaag aaaagaaagatgaggaggca gcgggcggtg cgccgcaagc 201 cgatacgcag gacgcaaccg ccggagaaggcagccaagat atggcggcag 251 tttcggcaga aaatacaggc aatggcggtg cggcaacaacggacaacccc 301 aaaaatgaag acgcgggggc gcaaaatgat atgccgcaaa atgccgccga351 atccgcaaat caaacaggga acaaccaacc cgccggttct tcagattccg 401cccccgcgtc aaaccctgcc cctgcgaatg gcggtagcga ttttggaagg 451 acgaacgtgggcaattctgt tgtgattgac ggaccgtcgc aaaatataac 501 gttgacccac tgtaaaggcgattcttgtaa tggtgataat ttattggatg 551 aagaagcacc gtcaaaatca gaatttgaaaaattaagtga tgaagaaaaa 601 attaagcgat ataaaaaaga cgagcaacgg gagaattttgtcggtttggt 651 tgctgacagg gtaaaaaagg atggaactaa caaatatatc atcttctata701 cggacaaacc acctactcgt tctgcacggt cgaggaggtc gcttccggcc 751gagattccgc tgattcccgt caatcaggcc gatacgctga ttgtggatgg 801 ggaagcggtcagcctgacgg ggcattccgg caatatcttc gcgcccgaag 851 ggaattaccg gtatctgacttacggggcgg aaaaattgcc cggcggatcg 901 tatgccctcc gtgtgcaagg cgaaccggcaaaaggcgaaa tgcttgttgg 951 cacggccgtg tacaacggcg aagtgctgca tttccatatggaaaacggcc 1001 gtccgtaccc gtccggaggc aggtttgccg caaaagtcga tttcggcagc1051 aaatctgtgg acggcattat cgacagcggc gatgatttgc atatgggtac 1101gcaaaaattc aaagccgcca tcgatggaaa cggctttaag gggacttgga 1151 cggaaaatggcggcggggat gtttccggaa ggttttacgg cccggccggc 1201 gaggaagtgg cgggaaaatacagctatcgc ccgacagatg ctgaaaaggg 1251 cggattcggc gtgtttgccg gcaaaaaagatcgggattgaThis corresponds to the amino acid sequence <SEQ ID 1200; ORF 287.ng>:

g287.pep 1 MFKRSVIAMA CIFPLSACGG GGGGSPDVKS ADTPSKPAAP VVAENAGEGV 51LPKEKKDEEA AGGAPQADTQ DATAGEGSQD MAAVSAENTG NGGAATTDNP 101 KNEDAGAQNDMPQNAAESAN QTGNNQPAGS SDSAPASNPA PANGGSDFGR 151 TNVGNSVVID GPSQNITLTHCKGDSCNGDN LLDEEAPSKS EFEKLSDEEK 201 IKRYKKDEQR ENFVGLVADR VKKDGTNKYIIFYTDKPPTR SARSRRSLPA 251 EIPLIPVNQA DTLIVDGEAV SLTGHSGNIF APEGNYRYLTYGAEKLPGGS 301 YALRVQGEPA KGEMLVGTAV YNGEVLHFHM ENGRPYPSGG RFAAKVDFGS351 KSVDGIIDSG DDLHMGTQKF KAAIDGNGFK GTWTENGGGD VSGRFYGPAG 401EEVAGKYSYR PTDAEKGGFG VFAGKKDRD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1201>:

m287.seq 1 ATGTTTAAAC GCAGCGTAAT CGCAATGGCT TGTATTTTTG CCCTTTCAGC 51CTGCGGGGGC GGCGGTGGCG GATCGCCCGA TGTCAAGTCG GCGGACACGC 101 TGTCAAAACCTGCCGCCCCT GTTGTTTCTG AAAAAGAGAC AGAGGCAAAG 151 GAAGATGCGC CACAGGCAGGTTCTCAAGGA CAGGGCGCGC CATCCGCACA 201 AGGCAGTCAA GATATGGCGG CGGTTTCGGAAGAAAATACA GGCAATGGCG 251 GTGCGGTAAC AGCGGATAAT CCCAAAAATG AAGACGAGGTGGCACAAAAT 301 GATATGCCGC AAAATGCCGC CGGTACAGAT AGTTCGACAC CGAATCACAC351 CCCGGATCCG AATATGCTTG CCGGAAATAT GGAAAATCAA GCAACGGATG 401CCGGGGAATC GTCTCAGCCG GCAAACCAAC CGGATATGGC AAATGCGGCG 451 GACGGAATGCAGGGGGACGA TCCGTCGGCA GGCGGGCAAA ATGCCGGCAA 501 TACGGCTGCC CAAGGTGCAAATCAAGCCGG AAACAATCAA GCCGCCGGTT 551 CTTCAGATCC CATCCCCGCG TCAAACCCTGCACCTGCGAA TGGCGGTAGC 601 AATTTTGGAA GGGTTGATTT GGCTAATGGC GTTTTGATTGACGGGCCGTC 651 GCAAAATATA ACGTTGACCC ACTGTAAAGG CGATTCTTGT AGTGGCAATA701 ATTTCTTGGA TGAAGAAGTA CAGCTAAAAT CAGAATTTGA AAAATTAAGT 751GATGCAGACA AAATAAGTAA TTACAAGAAA GATGGGAAGA ATGATAAATT 801 TGTCGGTTTGGTTGCCGATA GTGTGCAGAT GAAGGGAATC AATCAATATA 851 TTATCTTTTA TAAACCTAAACCCACTTCAT TTGCGCGATT TAGGCGTTCT 901 GCACGGTCGA GGCGGTCGCT TCCGGCCGAGATGCCGCTGA TTCCCGTCAA 951 TCAGGCGGAT ACGCTGATTG TCGATGGGGA AGCGGTCAGCCTGACGGGGC 1001 ATTCCGGCAA TATCTTCGCG CCCGAAGGGA ATTACCGGTA TCTGACTTAC1051 GGGGCGGAAA AATTGCCCGG CGGATCGTAT GCCCTTCGTG TTCAAGGCGA 1101ACCGGCAAAA GGCGAAATGC TTGCGGGCGC GGCCGTGTAC AACGGCGAAG 1151 TACTGCATTTCCATACGGAA AACGGCCGTC CGTACCCGAC CAGGGGCAGG 1201 TTTGCCGCAA AAGTCGATTTCGGCAGCAAA TCTGTGGACG GCATTATCGA 1251 CAGCGGCGAT GATTTGCATA TGGGTACGCAAAAATTCAAA GCCGCCATCG 1301 ATGGAAACGG CTTTAAGGGG ACTTGGACGG AAAATGGCAGCGGGGATGTT 1351 TCCGGAAAGT TTTACGGCCC GGCCGGCGAG GAAGTGGCGG GAAAATACAG1401 CTATCGCCCG ACAGATGCGG AAAAGGGCGG ATTCGGCGTG TTTGCCGGCA 1451AAAAAGAGCA GGATTGAThis corresponds to the amino acid sequence <SEQ ID 1202; ORF 287>:

m287.pep 1 MFKRSVIAMA CIFALSACGG GGGGSPDVKS ADTLSKPAAP VVSEKETEAK 51EDAPQAGSQG QGAPSAQGSQ DMAAVSEENT GNGGAVTADN PKNEDEVAQN 101 DMPQNAAGTDSSTPNHTPDP NMLAGNMENQ ATDAGESSQP ANQPDMANAA 151 DGMQGDDPSA GGQNAGNTAAQGANQAGNNQ AAGSSDPIPA SNPAPANGGS 201 NFGRVDLANG VLIDGPSQNI TLTHCKGDSCSGNNFLDEEV QLKSEFEKLS 251 DADKISNYKK DGKNDKFVGL VADSVQMKGI NQYIIFYKPKPTSFARFRRS 301 ARSRRSLPAE MPLIPVNQAD TLIVDGEAVS LTGHSGNIFA PEGNYRYLTY351 GAEKLPGGSY ALRVQGEPAK GEMLAGAAVY NGEVLHFHTE NGRPYPTRGR 401FAAKVDFGSK SVDGIIDSGD DLHMGTQKFK AAIDGNGFKG TWTENGSGDV 451 SGKFYGPAGEEVAGKYSYRP TDAEKGGFGV FAGKKEQD*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m287/g287 70.1% identity in 499 aa overlap          10        20        30        40                  49 m287.pep  MFKRSVIAMACIFALSACGGGGGGSPDVKSADTLSKPAAPVVSE-----------KETEA  ||||||||||||| ||||||||||||||||||| ||||||||:|           |: || g287  MFKRSVIAMACIFPLSACGGGGGGSPDVKSADTPSKPAAPVVAENAGEGVLPKEKKDEEA          10        20        30        40        50        60 50        60        70        80        90       100      109 m287.pep  KEDAPQAGSQGQGAPSAQGSQDMAAVSEENTGNGGAVTADNPKNEDEVAQNDMPQNAAGT     |||| :|   | :::||||||||| ||||||||:|:|||||||  |||||||||| g287  AGGAPQADTQD--ATAGEGSQDMAAVSAENTGNGGAATTDNPKNEDAGAQNDMPQNAA--          70          80        90       100       110110       120       130       140       150       160      169 m287.pep  DSSTPNHTPDPNMLAGNMENQATDAGESSQPANQPDMANAADGMQGDDPSAGGQNAGNTA g287  ------------------------------------------------------------170       180       190       200       210       220      229 m287.pep  AQGANQAGNNQAAGSSDPIPASNPAPANGGSNFGRVDLANGVLIDGPSQNITLTHCKGDS   ::|||:|||| |||||  ||||||||||||:|||::::|:|:||||||||||||||||| g287  -ESANQTGNNQPAGSSDSAPASNPAPANGGSDFGRTNVGNSVVIDGPSQNITLTHCKGDS    120       130       140       150       160       170230       240       250       260       270       280      289 m287.pep  CSGNNFLDEEVQLKSEFEKLSDADKISNYKKDGKNDKFVGLVADSVQMKGINQYIIFYKP  |:|:|:||||:  ||||||||| :||: |||| : ::||||||| |:  | |:||||| g287  CNGDNLLDEEAPSKSEFEKLSDEEKIKRYKKDEQRENFVGLVADRVKKDGTNKYIIFYTD    180       190       200       210       220       230290       300       310       320       330       340      349 m287.pep  KPTSFARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRYLT  || :     ||||||||||||:|||||||||||||||||||||||||||||||||||||| g287  KPPT-----RSARSRRSLPAEIPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRYLT         240       250       260       270       280       290350       360       370       380       390       400      409 m287.pep  YGAEKLPGGSYALRVQGEPAKGEMLAGAAVYNGEVLHFHTENGRPYPTRGRFAAKVDFGS  |||||||||||||||||||||||||:|:||||||||||| |||||||: ||||||||||| g287  YGAEKLPGGSYALRVQGEPAKGEMLVGTAVYNGEVLHFHMENGRPYPSGGRFAAKVDFGS         300       310       320       330       340       350410       420       430       440       450       460      469 m287.pep  KSVDGIIDSGDDLHMGTQKFKAAIDGNGFKGTWTENGSGDVSGKFYGPAGEEVAGKYSYR  |||||||||||||||||||||||||||||||||||||:|||||:|||||||||||||||| g287  KSVDGIIDSGDDLHMGTQKFKAAIDGNGFKGTWTENGGGDVSGRFYGPAGEEVAGKYSYR         360       370       380       390       400       410470       480      489 m287.pep   PTDAEKGGFGVFAGKKEQDX  ||||||||||||||||::|| g287   PTDAEKGGFGVFAGKKDRDX         420       430The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1203>:

a287.seq 1 ATGTTTAAAC GCAGTGTGAT TGCAATGGCT TGTATTGTTG CCCTTTCAGC 51CTGTGGGGGC GGCGGTGGCG GATCGCCCGA TGTTAAGTCG GCGGACACGC 101 TGTCAAAACCTGCCGCCCCT GTTGTTACTG AAGATGTCGG GGAAGAGGTG 151 CTGCCGAAAG AAAAGAAAGATGAGGAGGCG GTGAGTGGTG CGCCGCAAGC 201 CGATACGCAG GACGCAACCG CCGGAAAAGGCGGTCAAGAT ATGGCGGCAG 251 TTTCGGCAGA AAATACAGGC AATGGCGGTG CGGCAACAACGGATAATCCC 301 GAAAATAAAG ACGAGGGACC GCAAAATGAT ATGCCGCAAA ATGCCGCCGA351 TACAGATAGT TCGACACCGA ATCACACCCC TGCACCGAAT ATGCCAACCA 401GAGATATGGG AAACCAAGCA CCGGATGCCG GGGAATCGGC ACAACCGGCA 451 AACCAACCGGATATGGCAAA TGCGGCGGAC GGAATGCAGG GGGACGATCC 501 GTCGGCAGGG GAAAATGCCGGCAATACGGC AGATCAAGCT GCAAATCAAG 551 CTGAAAACAA TCAAGTCGGC GGCTCTCAAAATCCTGCCTC TTCAACCAAT 601 CCTAACGCCA CGAATGGCGG CAGCGATTTT GGAAGGATAAATGTAGCTAA 651 TGGCATCAAG CTTGACAGCG GTTCGGAAAA TGTAACGTTG ACACATTGTA701 AAGACAAAGT ATGCGATAGA GATTTCTTAG ATGAAGAAGC ACCACCAAAA 751TCAGAATTTG AAAAATTAAG TGATGAAGAA AAAATTAATA AATATAAAAA 801 AGACGAGCAACGAGAGAATT TTGTCGGTTT GGTTGCTGAC AGGGTAGAAA 851 AGAATGGAAC TAACAAATATGTCATCATTT ATAAAGACAA GTCCGCTTCA 901 TCTTCATCTG CGCGATTCAG GCGTTCTGCACGGTCGAGGC GGTCGCTTCC 951 GGCCGAGATG CCGCTGATTC CCGTCAATCA GGCGGATACGCTGATTGTCG 1001 ATGGGGAAGC GGTCAGCCTG ACGGGGCATT CCGGCAATAT CTTCGCGCCC1051 GAAGGGAATT ACCGGTATCT GACTTACGGG GCGGAAAAAT TGTCCGGCGG 1101ATCGTATGCC CTCAGTGTGC AAGGCGAACC GGCAAAAGGC GAAATGCTTG 1151 CGGGCACGGCCGTGTACAAC GGCGAAGTGC TGCATTTCCA TATGGAAAAC 1201 GGCCGTCCGT CCCCGTCCGGAGGCAGGTTT GCCGCAAAAG TCGATTTCGG 1251 CAGCAAATCT GTGGACGGCA TTATCGACAGCGGCGATGAT TTGCATATGG 1301 GTACGCAAAA ATTCAAAGCC GTTATCGATG GAAACGGCTTTAAGGGGACT 1351 TGGACGGAAA ATGGCGGCGG GGATGTTTCC GGAAGGTTTT ACGGCCCGGC1401 CGGCGAAGAA GTGGCGGGAA AATACAGCTA TCGCCCGACA GATGCGGAAA 1451AGGGCGGATT CGGCGTGTTT GCCGGCAAAA AAGAGCAGGA TTGAThis corresponds to the amino acid sequence <SEQ ID 1204; ORF 287.a>:

a287.pep 1 MFKRSVIAMA CIVALSACGG GGGGSPDVKS ADTLSKPAAP VVTEDVGEEV 51LPKEKKDEEA VSGAPQADTQ DATAGKGGQD MAAVSAENTG NGGAATTDNP 101 ENKDEGPQNDMPQNAADTDS STPNHTPAPN MPTRDMGNQA PDAGESAQPA 151 NQPDMANAAD GMQGDDPSAGENAGNTADQA ANQAENNQVG GSQNPASSTN 201 PNATNGGSDF GRINVANGIK LDSGSENVTLTHCKDKVCDR DFLDEEAPPK 251 SEFEKLSDEE KINKYKKDEQ RENFVGLVAD RVEKNGTNKYVIIYKDKSAS 301 SSSARFRRSA RSRRSLPAEM PLIPVNQADT LIVDGEAVSL TGHSGNIFAP351 EGNYRYLTYG AEKLSGGSYA LSVQGEPAKG EMLAGTAVYN GEVLHFHMEN 401GRPSPSGGRF AAKVDFGSKS VDGIIDSGDD LHMGTQKFKA VIDGNGFKGT 451 WTENGGGDVSGRFYGPAGEE VAGKYSYRPT DAEKGGFGVF AGKKEQD* m287/a287 77.2% identity in501 aa overlap          10        20        30        40                  49 m287.pep  MFKRSVIAMACIFALSACGGGGGGSPDVKSADTLSKPAAPVVSE-----------KETEA  |||||||||||| |||||||||||||||||||||||||||||:|           |: || a287  MFKRSVIAMACIVALSACGGGGGGSPDVKSADTLSKPAAPVVTEDVGEEVLPKEKKDEEA          10        20        30        40        50        60 50        60        70        80        90       100      109 m287.pep  KEDAPQAGSQGQGAPSAQGSQDMAAVSEENTGNGGAVTADNPKNEDEVAQNDMPQNAAGT     |||| :|   | :::|:||||||| ||||||||:|:|||:|:||  ||||||||| | a287  VSGAPQADTQ--DATAGKGGQDMAAVSAENTGNGGAATTDNPENKDEGPQNDMPQNAADT          70         80        90       100       110110       120       130       140       150       160      169 m287.pep  DSSTPNHTPDPNMLAGNMENQATDAGESSQPANQPDMANAADGMQGDDPSAGGQNAGNTA  ||||||||| ||| : :| ||| |||||:||||||||||||||||||||||| :|||||| a287  DSSTPNHTPAPNMPTRDMGNQAPDAGESAQPANQPDMANAADGMQGDDPSAG-ENAGNTA 120       130       140       150       160       170170       180       190       200       210       220      229 m287.pep  AQGANQAGNNQAAGSSDPIPASNPAPANGGSNFGRVDLANGVLIDGPSQNITLTHCKGDS   |:|||| |||::||::|  ::||  :||||:|||:::|||: :|: |:|:|||||| a287  DQAANQAENNQVGGSQNPASSTNPNATNGGSDFGRINVANGIKLDSGSENVTLTHCKDKV  180       190       200       210       220       230230       240       250       260       270       280      289 m287.pep  CSGNNFLDEEVQLKSEFEKLSDADKISNYKKDGKNDKFVGLVADSVQMKGINQYIIFYKP  |:  :|||||:  ||||||||| :||::|||| : ::||||||| |: :| |:|:|:|| a287  CD-RDFLDEEAPPKSEFEKLSDEEKINKYKKDEQRENFVGLVADRVEKNGTNKYVIIYKD   240       250       260       270       280       290290         300       310       320       330       340 m287.pep  KP--TSFARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRY  |   :| ||||||||||||||||||||||||||||||||||||||||||||||||||||| a287  KSASSSSARFRRSARSRRSLPAEMPLIPVNQADTLIVDGEAVSLTGHSGNIFAPEGNYRY   300       310       320       330       340       350  350       360       370       380       390       400 m287.pep  LTYGAEKLPGGSYALRVQGEPAKGEMLAGAAVYNGEVLHFHTENGRPYPTRGRFAAKVDF  |||||||| |||||| |||||||||||||:||||||||||| ||||| |: ||||||||| a287  LTYGAEKLSGGSYALSVQGEPAKGEMLAGTAVYNGEVLHFHMENGRPSPSGGRFAAKVDF   360       370       380       390       400       410  410       420       430       440       450       460 m287.pep  GSKSVDGIIDSGDDLHMGTQKFKAAIDGNGFKGTWTENGSGDVSGKFYGPAGEEVAGKYS  ||||||||||||||||||||||||:||||||||||||||:|||||:|||||||||||||| a287  GSKSVDGIIDSGDDLHMGTQKFKAVIDGNGFKGTWTENGGGDVSGRFYGPAGEEVAGKYS   420       430       440       450       460       470  470       480      489 m287.pep   YRPTDAEKGGFGVFAGKKEQDX  |||||||||||||||||||||| a287   YRPTDAEKGGFGVFAGKKEQDX    480       490The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1205>:

g288.seq 1 atgcacaccg gacaggcggt aagccgggtt ctgtctcgga cagtcattcc 51tctaggcata ccgttgccgg tatgctcaag caacctaccc gaacgctcgg 101 cgggcagcgtcattgcgttc tgtttggtct tgctccgaat ggggtttggc 151 ctgccgcata ttgttaccaaatgcgcggtg cgcccttacc gcaccttttc 201 acccttgcct gtgctgccaa agcagccatcggcggttttg ctttctgttc 251 cactttccgt cgcgttaccg cgcccggccg ttaaccggcattctaccctg 301 cggagcccgg actttcctcc ccgtatgcct tacgcgatac gcggcgactg351 tctgcccgtc ccgtgtgcgg cgcggattat aacacgaaac gcaaaaatgc 401cgtctgaaac ggtacaggtt tcagacggca tacagcctaa actacacacc 451 ctgtttcaggctggcttcga tgaagccgtc caagtcgccg tccaatacgg 501 ctttgtggtt gccgacttcgtagcctgtac gcaagtcttt gatgcgtgaThis corresponds to the amino acid sequence <SEQ ID 1206; ORF 288.ng>:

g288.pep 1 MHTGQAVSRV LSRTVIPLGI PLPVCSSNLP ERSAGSVIAF CLVLLRMGFG 51LPHIVTKCAV RPYRTFSPLP VLPKQPSAVL LSVPLSVALP RPAVNRHSTL 101 RSPDFPPRMPYAIRGDCLPV PCAARIITRN AKMPSETVQV SDGIQPKLHT 151 LFQAGFDEAV QVAVQYGFVVADFVACTQVF DA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1207>:

m288.seq 1 ATGCACACCG GACAGGCGGT AAGCCGGGTT CTGTCTCGGA CAGTCATTCC 51TCTAGGCATA CCGTTACCGG TATGCTCAAG CAACCTACCC GAACGCTCGG 101 CGGGCAGCGTCATTGCGTTC TGTTTGGTCT TGCTCCGAAT GGGGTTTGGC 151 CTGCCGCATA TTGTTACCAAATGCGCGGTG CGCCCTTACC GCACCTTTTC 201 ACCCTTACCT GTGCTGCCAA AGCAGCCATCGGCGGTTTTG CTTTCTGTTC 251 CACTTTCCGT CGCGTTACCG CGCCCGGCCG TTAACCGGCATTCTACCCTG 301 CGGAGCCCGG ACTTTCCTCC CCGTATGCCT TACGCGATAC GCGGCGACTG351 TCTGCCCGTC CCGTGTGCGG CGCGGATTAT AACACGAAAC ACAAAAATGC 401CGTCTGAAAC GGTACAGGTT TCAGACGGCA TACAGCCTAA ACTACACGCC 451 CTGTTTCAGGCTGGCTTCGA TGAAGCCGTC CAAGTCGCCA TCCAATACGG 501 CTTTGGTGTT GCCGACTTCGTAGCCTGTAC GCAAGTCTTT GATACGTGAThis corresponds to the amino acid sequence <SEQ ID 1208; ORF 288>:

m288.pep 1 MHTGQAVSRV LSRTVIPLGI PLPVCSSNLP ERSAGSVIAF CLVLLRMGFG 51LPHIVTKCAV RPYRTFSPLP VLPKQPSAVL LSVPLSVALP RPAVNRHSTL 101 RSPDFPPRMPYAIRGDCLPV PCAARIITRN TKMPSETVQV SDGIQPKLHA 151 LFQAGFDEAV QVAIQYGFGVADFVACTQVF DT*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m288/g288 97.8% identity in 181 aa overlap        10        20        30        40        50        60 m288.pepMHTGQAVSRVLSRTVIPLGIPLPVCSSNLPERSAGSVIAFCLVLLRMGFGLPHIVTKCAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g288MHTGQAVSRVLSRTVIPLGIPLPVCSSNLPERSAGSVIAFCLVLLRMGFGLPHIVTKCAV        10        20        30        40        50        60        70        80        90       100       110       120 m288.pepRPYRTFSPLPVLPKQPSAVLLSVPLSVALPRPAVNRHSTLRSPDFPPRMPYAIRGDCLPV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g288RPYRTFSPLPVLPKQPSAVLLSVPLSVALPRPAVNRHSTLRSPDFPPRMPYAIRGDCLPV        70        80        90       100       110       120       130       140       150       160       170       180 m288.pepPCAARIITRNTKMPSETVQVSDGIQPKLHALFQAGFDEAVQVAIQYGFGVADFVACTQVF||||||||||:||||||||||||||||||:|||||||||||||:|||| ||||||||||| g288PCAARIITRNAKMPSETVQVSDGIQPKLHTLFQAGFDEAVQVAVQYGFVVADFVACTQVF       130       140       150       160       170       180 m288.pepDTX |:| g288 DAXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1209>:

a288.seq 1 ATGCACACCG GACAGGCGGT AAGCCGGGTT CTGTCTCGGA CAGTCATTCC 51TCTAGGCATA CCGTTGCCGG TATGCTCAAG CAACCTACCC GAACGCTCGG 101 CGGGCAGCGTCATTGCGTTC TGTTTGGTCT TGCTCCGAAT GGGGTTTGGC 151 CTGCCGCATA TTGTTACCAAATGCGCGGTG CGCCCTTACC GCACCTTTTC 201 ACCCTTGCCT GTGCTGCCAA AGCAGCCATCGGCGGTTTTG CTTTCTGTTC 251 CACTTTCCGT CGCGTTACCG CGCCCGGCCG TTAACCGGCATTCTACCCTG 301 CGGAGCCCGG ACTTTCCTCC CCGTATGCCT TACGCGATAC GCGGCGACTG351 TCTGCCCGTC CCGTGTGCGG CGCGGATTAT AACACGAAAC GCAAAAATGC 401CGTCTGAAAC GGTACAGGTT TCAGACGGCA TACAGCCTAA ACTACACGCC 451 CTGTTTCAGGCTGGCTTCGA TAAAGCCGTC CAAGTCGCCG TCCAATACGG 501 CTTTGGTGTT GCCGACTTCGTAGCCTGTGC GCAAGTCTTT AATGCGTGAThis corresponds to the amino acid sequence <SEQ ID 1210; ORF 288.a>:

a288.pep 1 MHTGQAVSRV LSRTVIPLGI PLPVCSSNLP ERSAGSVIAF CLVLLRMGFG 51LPHIVTKCAV RPYRTFSPLP VLPKQPSAVL LSVPLSVALP RPAVNRHSTL 101 RSPDFPPRMPYAIRGDCLPV PCAARIITRN AKMPSETVQV SDGIQPKLHA 151 LFQAGFDKAV QVAVQYGFGVADFVACAQVF NA* m288/a288 97.2% identity in 181 aa overlap        10        20        30        40        50        60 m288.pepMHTGQAVSRVLSRTVIPLGIPLPVCSSNLPERSAGSVIAFCLVLLRMGFGLPHIVTKCAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a288MHTGQAVSRVLSRTVIPLGIPLPVCSSNLPERSAGSVIAFCLVLLRMGFGLPHIVTKCAV        10        20        30        40        50        60        70        80        90       100       110       120 m288.pepRPYRTFSPLPVLPKQPSAVLLSVPLSVALPRPAVNRHSTLRSPDFPPRMPYAIRGDCLPV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a288RPYRTFSPLPVLPKQPSAVLLSVPLSVALPRPAVNRHSTLRSPDFPPRMPYAIRGDCLPV        70        80        90       100       110       120       130       140       150       160       170       180 m288.pepPCAARIITRNTKMPSETVQVSDGIQPKLHALFQAGFDEAVQVAIQYGFGVADFVACTQVF||||||||||:||||||||||||||||||||||||||:|||||:||||||||||||:||| a288PCAARIITRNAKMPSETVQVSDGIQPKLHALFQAGFDKAVQVAVQYGFGVADFVACAQVF       130       140       150       160       170       180 m288.pepDTX :: a288 NAXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1211>:

g290.seq 1 atggcaaaaa tgatgaaatg ggcggctgtt gcggcggtcg cggcggcagc 51ggtttggggc ggatggtctt atctgaagcc cgaaccgcag gctgcttata 101 ttacggaagcggtcaggcgc ggcgatatca gccggacggt ttccgcgacg 151 ggcgagattt cgccgtccaacctggtatcg gtcggcgcgc aggcttcggg 201 gcagattaaa aagctttatg tcaaactcgggcaacaggtc aaaaagggcg 251 atttgattgc ggaaatcaat tcgaccacgc agaccaacacgatcgatatg 301 gaaaaatcca aattggaaac gtatcaggcg aagctggtgt ccgcacagat351 tgcattgggc agcgcggaaa aaaaatataa gcgtcaggcg gcgttgtgga 401aggatgatgc gacctctaaa gaagatttgg aaagcgcgca ggatgcgctt 451 gccgccgccaaagccaatgt tgccgagttg aaggctttaa tcagacagag 501 caaaatttcc atcaataccgccgagtcgga tttgggctac acgcgcatta 551 ccgcgacgat ggacggcacg gtggtggcgattcccgtgga agaggggcag 601 actgtgaacg cggcgcagtc tacgccgacg attgtccaattggcgaatct 651 ggatatgatg ttgaacaaaa tgcagattgc cgagggcgat attaccaagg701 tgaaggcggg gcaggatatt tcgtttacga ttttgtccga accggatacg 751ccgattaagg cgaagctcga cagcgtcgac cccgggctga ccacgatgtc 801 gtcgggcggctacaacagca gtacggatac ggcttccaat gcggtctatt 851 attatgcccg ttcgtttgtgccgaatccgg acggcaaact cgccacgggg 901 atgacgacgc agaatacggt tgaaatcgacggtgtgaaaa atgtgttgct 951 tattccgtcg ctgaccgtga aaaatcgcgg cggcaaggcgttcgtacgcg 1001 tgttgggtgc ggacggcaag gcagtggaac gcgaaatccg gaccggtatg1051 aaagacagta tgaataccga agtgaaaagc gggttgaaag agggggacaa 1101agtggtcatc tccgaaataa ccgccgccga gcagcaggaa agcggcgaac 1151 gcgccctaggcggcccgccg cgccgataaThis corresponds to the amino acid sequence <SEQ ID 1212; ORF 290.ng>:

g290.pep 1 MAKMMKWAAV AAVAAAAVWG GWSYLKPEPQ AAYITEAVRR GDISRTVSAT 51GEISPSNLVS VGAQASGQIK KLYVKLGQQV KKGDLIAEIN STTQTNTIDM 101 EKSKLETYQAKLVSAQIALG SAEKKYKRQA ALWKDDATSK EDLESAQDAL 151 AAAKANVAEL KALIRQSKISINTAESDLGY TRITATMDGT VVAIPVEEGQ 201 TVNAAQSTPT IVQLANLDMM LNKMQIAEGDITKVKAGQDI SFTILSEPDT 251 PIKAKLDSVD PGLTTMSSGG YNSSTDTASN AVYYYARSFVPNPDGKLATG 301 MTTQNTVEID GVKNVLLIPS LTVKNRGGKA FVRVLGADGK AVEREIRTGM351 KDSMNTEVKS GLKEGDKVVI SEITAAEQQE SGERALGGPP RR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1213>:

m290.seq (partial) 1 ..GTATCGGTCG GCGCGCAGGC ATCGGGGCAG ATTAAGATACTTTATGTCAA 51   ACTCGGGCAA CAGGTTAAAA AGGGCGATTT GATTGCGGAA ATCAATTCGA101   CCTCGCAGAC CAATACGCTC AATACGGAAA AATCCAAGTT GGAAACGTAT 151  CAGGCGAAGC TGGTGTCGGC ACAGATTGCA TTGGGCAGCG CGGAGAAGAA 201  ATATAAGCGT CAGGCGGCGT TATGGAAGGA AAACGCGACT TCCAAAGAGG 251  ATTTGGAAAG CGCGCAGGAT GCGTTTGCCG CCGCCAAAGC CAATGTTGCC 301  GAGCTGAAGG CTTTAATCAG ACAGAGCAAA ATTTCCATCA ATACCGCCGA 351  GTCGGAATTG GGCTACACGC GCATTACCGC AACGATGGAC GGCACGGTGG 401  TGGCGATTCT CGTGGAAGAG GGGCAGACTG TGAACGCGGC GCAGTCTACG 451  CCGACGATTG TCCAATTGGC GAATCTGGAT ATGATGTTGA ACAAAATGCA 501  GATTGCCGAG GGCGATATTA CCAAGGTGAA GGCGGGGCAG GATATTTCGT 551  TTACGATTTT GTCCGAACCG GATACGCCGA TTAAGGCGAA GCTCGACAGC 601  GTCGACCCCG GGCTGACCAC GATGTCGTCG GGCGGTTACA ACAGCAGTAC 651  GGATACGGCT TCCAATGCGG TCTACTATTA TGCCCGTTCG TTTGTGCCGA 701  ATCCGGACGG CAAACTCGCC ACGGGGATGA CGACGCAGAA TACGGTTGAA 751  ATCGACGGCG TGAAAAATGT GCTGATTATT CCGTCGCTGA CCGTGAAAAA 801  TCGCGGCGGC AAGGCGTTTG TGCGCGTGTT GGGTGCGGAC GGCAAGGCGG 851  CGGAACGCGA AATCCGGACC GGTATGAGAG ACAGTATGAA TACCGAAGTA 901  AAAAGCGGGT TGAAAGAGGG GGACAAAGTG GTCATCTCCG AAATAACCGC 951  CGCCGAGCAA CAGGAAAGCG GCGAACGCGC CCTAGGCGGC CCGCCGCGCC 1001   GATAAThis corresponds to the amino acid sequence <SEQ ID 1214; ORF 290>:

m290.pep (partial) 1 ..VSVGAQASGQ IKILYVKLGQ QVKKGDLIAE INSTSQTNTLNTEKSKLETY 51   QAKLVSAQIA LGSAEKKYKR QAALWKENAT SKEDLESAQD AFAAAKANVA101   ELKALIRQSK ISINTAESEL GYTRITATMD GTVVAILVEE GQTVNAAQST 151  PTIVQLANLD MMLNKMQIAE GDITKVKAGQ DISFTILSEP DTPIKAKLDS 201  VDPGLTTMSS GGYNSSTDTA SNAVYYYARS FVPNPDGKLA TGMTTQNTVE 251  IDGVKNVLII PSLTVKNRGG KAFVRVLGAD GKAAEREIRT GMRDSMNTEV 301  KSGLKEGDKV VISEITAAEQ QESGERALGG PPRR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m290/g290 96.1% identity in 334 aa overlap                                       10        20        30 m290.pep                               VSVGAQASGQIKILYVKLGQQVKKGDLIAE                               |||||||||||| ||||||||||||||||| g290 PQAAYITEAVRRGDISRTVSATGEISPSNLVSVGAQASGQIKKLYVKLGQQVKKGDLIAE 30        40        50        60        70        80         40        50        60        70        80        90 m290.pep INSTSQTNTLNTEKSKLETYQAKLVSAQIALGSAEKKYKRQAALWKENATSKEDLESAQD ||||:||||:: ||||||||||||||||||||||||||||||||||::|||||||||||| g290 INSTTQTNTIDMEKSKLETYQAKLVSAQIALGSAEKKYKRQAALWKDDATSKEDLESAQD 90       100       110       120       130       140        100       110       120       130       140       150 m290.pep AFAAAKANVAELKALIRQSKISINTAESELGYTRITATMDGTVVAILVEEGQTVNAAQST |:||||||||||||||||||||||||||:||||||||||||||||| ||||||||||||| g290 ALAAAKANVAELKALIRQSKISINTAESDLGYTRITATMDGTVVAIPVEEGQTVNAAQST150       160       170       180       190       200        160       170       180       190       200       210 m290.pep PTIVQLANLDMMLNKMQIAEGDITKVKAGQDISFTILSEPDTPIKAKLDSVDPGLTTMSS |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g290 PTIVQLANLDMMLNKMQIAEGDITKVKAGQDISFTILSEPDTPIKAKLDSVDPGLTTMSS210       220       230       240       250       260        220       230       240       250       260       270 m290.pep GGYNSSTDTASNAVYYYARSFVPNPDGKLATGMTTQNTVEIDGVKNVLIIPSLTVKNRGG ||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||| g290 GGYNSSTDTASNAVYYYARSFVPNPDGKLATGMTTQNTVEIDGVKNVLLIPSLTVKNRGG270       280       290       300       310       320        280       290       300       310       320       330 m290.pep KAFVRVLGADGKAAEREIRTGMRDSMNTEVKSGLKEGDKVVISEITAAEQQESGERALGG |||||||||||||:||||||||:||||||||||||||||||||||||||||||||||||| g290 KAFVRVLGADGKAVEREIRTGMKDSMNTEVKSGLKEGDKVVISEITAAEQQESGERALGG330       340       350       360       370       380 m290.pep  PPRRX ||||| g290  PPRRX 390The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1215>:

a290.seq 1 ATGGCAAAAA TGATGAAATG GGCGGCTGTT GCGGCGGTCG CGGCGGCAGC 51GGTTTGGGGC GGATGGTCTT ATCTGAAGCC CGAGCCGCAG GCTGCTTATA 101 TTACGGAAACGGTCAGGCGC GGCGACATCA GCCGGACGGT TTCTGCAACA 151 GGGGAGATTT CGCCGTCCAACCTGGTATCG GTCGGCGCGC AGGCATCGGG 201 GCAGATTAAG AAACTTTATG TCAAACTCGGGCAACAGGTT AAAAAGGGCG 251 ATTTGATTGC GGAAATCAAT TCGACCTCGC AGACCAATACGCTCAATACG 301 GAAAAATCCA AATTGGAAAC GTATCAGGCG AAGCTGGTGT CGGCACAGAT351 TGCATTGGGC AGCGCGGAGA AGAAATATAA GCGTCAGGCG GCGTTGTGGA 401AGGATGATGC GACCGCTAAA GAAGATTTGG AAAGCGCACA GGATGCGCTT 451 GCCGCCGCCAAAGCCAATGT TGCCGAGCTG AAGGCTCTAA TCAGACAGAG 501 CAAAATTTCC ATCAATACCGCCGAGTCGGA ATTGGGCTAC ACGCGCATTA 551 CCGCAACGAT GGACGGCACG GTGGTGGCGATTCTCGTGGA AGAGGGGCAG 601 ACTGTGAACG CGGCGCAGTC TACGCCGACG ATTGTCCAATTGGCGAATCT 651 GGATATGATG TTGAACAAAA TGCAGATTGC CGAGGGCGAT ATTACCAAGG701 TGAAGGCGGG GCAGGATATT TCGTTTACGA TTTTGTCCGA ACCGGATACG 751CCGATTAAGG CGAAGCTCGA CAGCGTCGAC CCCGGGCTGA CCACGATGTC 801 GTCGGGCGGCTACAACAGCA GTACGGATAC GGCTTCCAAT GCGGTCTACT 851 ATTATGCCCG TTCGTTTGTGCCGAATCCGG ACGGCAAACT CGCCACGGGG 901 ATGACGACGC AGAATACGGT TGAAATCGACGGTGTGAAAA ATGTGCTGAT 951 TATTCCGTCG CTGACCGTGA AAAATCGCGG CGGCAGGGCGTTTGTGCGCG 1001 TGTTGGGTGC AGACGGCAAG GCGGCGGAAC GCGAAATCCG GACCGGTATG1051 AGAGACAGTA TGAATACCGA AGTAAAAAGC GGGTTGAAAG AGGGGGACAA 1101AGTGGTCATC TCCGAAATAA CCGCCGCCGA GCAGCAGGAA AGCGGCGAAC 1151 GCGCCCTAGGCGGCCCGCCG CGCCGATAAThis corresponds to the amino acid sequence <SEQ ID 1216; ORF 290.a>:

a290.pep 1 MAKMMKWAAV AAVAAAAVWG GWSYLKPEPQ AAYITETVRR GDISRTVSAT 51GEISPSNLVS VGAQASGQIK KLYVKLGQQV KKGDLIAEIN STSQTNTLNT 101 EKSKLETYQAKLVSAQIALG SAEKKYKRQA ALWKDDATAK EDLESAQDAL 151 AAAKANVAEL KALIRQSKISINTAESELGY TRITATMDGT VVAILVEEGQ 201 TVNAAQSTPT IVQLANLDMM LNKMQIAEGDITKVKAGQDI SFTILSEPDT 251 PIKAKLDSVD PGLTTMSSGG YNSSTDTASN AVYYYARSFVPNPDGKLATG 301 MTTQNTVEID GVKNVLIIPS LTVKNRGGRA FVRVLGADGK AAEREIRTGM351 RDSMNTEVKS GLKEGDKVVI SEITAAEQQE SGERALGGPP RR* m290/a290 98.2%identity in 334 aa overlap                                       10        20        30 m290.pep                               VSVGAQASGQIKILYVKLGQQVKKGDLIAE                               |||||||||||| ||||||||||||||||| a290 PQAAYITETVRRGDISRTVSATGEISPSNLVSVGAQASGQIKKLYVKLGQQVKKGDLIAE 30        40        50        60        70        80         40        50        60        70        80        90 m290.pep INSTSQTNTLNTEKSKLETYQAKLVSAQIALGSAEKKYKRQAALWKENATSKEDLESAQD ||||||||||||||||||||||||||||||||||||||||||||||::||:||||||||| a290 INSTSQTNTLNTEKSKLETYQAKLVSAQIALGSAEKKYKRQAALWKDDATAKEDLESAQD 90       100       110       120       130       140        100       110       120       130       140       150 m290.pep AFAAAKANVAELKALIRQSKISINTAESELGYTRITATMDGTVVAILVEEGQTVNAAQST |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a290 ALAAAKANVAELKALIRQSKISINTAESELGYTRITATMDGTVVAILVEEGQTVNAAQST150       160       170       180       190       200        160       170       180       190       200       210 m290.pep PTIVQLANLDMMLNKMQIAEGDITKVKAGQDISFTILSEPDTPIKAKLDSVDPGLTTMSS |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a290 PTIVQLANLDMMLNKMQIAEGDITKVKAGQDISFTILSEPDTPIKAKLDSVDPGLTTMSS210       220       230       240       250       260        220       230       240       250       260       270 m290.pep GGYNSSTDTASNAVYYYARSFVPNPDGKLATGMTTQNTVEIDGVKNVLIIPSLTVKNRGG |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a290 GGYNSSTDTASNAVYYYARSFVPNPDGKLATGMTTQNTVEIDGVKNVLIIPSLTVKNRGG270       280       290       300       310       320        280       290       300       310       320       330 m290.pep KAFVRVLGADGKAAEREIRTGMRDSMNTEVKSGLKEGDKVVISEITAAEQQESGERALGG :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a290 RAFVRVLGADGKAAEREIRTGMRDSMNTEVKSGLKEGDKVVISEITAAEQQESGERALGG330       340       350       360       370       380 m290.pep  PPRRX ||||| a290  PPRRX 390The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1217>:

g292.seq 1 atgaaaacca agttaatcaa aatcttgacc ccctttaccg tcctgccgct 51gctggcttgc gggcaaacgc ccgtttccaa tgccaacgcc gaatccgccg 101 tcaaagccgaatccgccggc aaatccgttg ccgcttcttt gaaagcgcgt 151 ttggaaaaaa cctattccgcccaagatttg aaagtgttga gcgtcagcga 201 aacaccggtc aaaggcattt acgaagtcgtcgtcagcggc aggcagatta 251 tctacaccga tgccgaaggc ggctatatgt tcgtcggcgaactcatcaac 301 atcgacacgc gcaaaaacct gaccgaagaa cgcgccgccg atttgaacaa351 aatcgacttc gcctccctgc ctttggacaa agccatcaaa gaagtacgcg 401gcaacggcaa gctgaaagtc gccgtcttct ccgaccccga ttgtccgttc 451 tgcaaacgcttggaacatga gtttgaaaaa atgaccgacg tgacggttta 501 cagctttatg atgcccattgccggcctgca cccagatgcc gcgcgcaagg 551 cgcaaatctt atggtgtcag cccgaccgtgccaaagcgtg gacggattgg 601 atgcgtaaag gcaaattccc ggtcggcggc agcatctgcgacaatcccgt 651 cgcggaaacc acttccttgg gcgaacagtt cggcttcaac ggcacgccga701 cccttcgtct tccccaacgg gcgcacccaa agcggttaca gcccgatgcc 751ccaactggag gaaatcatcc gcaaaaacca gcagtaaacc cgcaatgaThis corresponds to the amino acid sequence <SEQ ID 1218; ORF 292.ng>:

g292.pep 1 MKTKLIKILT PFTVLPLLAC GQTPVSNANA ESAVKAESAG KSVAASLKAR 51LEKTYSAQDL KVLSVSETPV KGIYEVVVSG RQIIYTDAEG GYMFVGELIN 101 IDTRKNLTEERAADLNKIDF ASLPLDKAIK EVRGNGKLKV AVFSDPDCPF 151 CKRLEHEFEK MTDVTVYSFMMPIAGLHPDA ARKAQILWCQ PDRAKAWTDW 201 MRKGKFPVGG SICDNPVAET TSLGEQFGFNGTPTLRLPQR AHPKRLQPDA 251 PTGGNHPQKP AVNPQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1219>:

m292.seq 1 ATGAAAACCA AGTTAATCAA AATCTTGACC CCCTTTACCG TCCTCCCGCT 51GCTGGCTTGC GGGCAAACGC CCGTTTCCAA TGCCAACGCC GAACCCGCCG 101 TCAAAGCCGAGTCCGCCGGC AAATCCGTTG CCGCCTCTTT GAAAGCGCGT 151 TTGGAAAAAA CCTATTCCGCCCAAGATTTG AAAGTGTTGA GCGTCAGCGA 201 AACACCGGTC AAAGGCATTT ACGAAGTCGTCGTCAGCGGC AGGCAGATTA 251 TCTACACCGA TGCCGAAGGC GGCTATATGT TCGTCGGCGAACTCATCAAC 301 ATCGACACGC GCAAAAACCT GACCGAAGAA CGCGCCGCCG ATTTGAACAA351 AATCGACTTC GCCTCCCTGC CTTTGGACAA AGCCATCAAA GAAGTGCGCG 401GCAACGGCAA GCTGAAAGTC GCCGTCTTCT CCGACCCCGA TTGTCCGTTC 451 TGCAAACGCTTGGAACACGA GTTTGAAAAA ATGACCGACG TGACGGTTTA 501 CAGCTTTATG ATGCCCATTGCCGGCCTGCA CCCCGATGCC GCGCGCAAGG 551 CGCAAATCTT ATGGTGTCAG CCCGACCGCGCCAAAGCGTG GACGGATTGG 601 ATGCGTAAAG GCAAATTCCC GGTCGGCGGC AGCATCTGCGACAATCCCGT 651 CGCGGAAACC ACTTCCTTGG GCGAACAATT CGGCTTCAAC GGCACGCCGA701 CCCTCGTCTT CCCCAACGGG CGCAGCCAAA GCGGCTACAG CCCGATGCCC 751CAACTGGAGG AAATCATCCG CAAAAATCAA TAAThis corresponds to the amino acid sequence <SEQ ID 1220; ORF 292>:

m292.pep 1 MKTKLIKILT PFTVLPLLAC GQTPVSNANA EPAVKAESAG KSVAASLKAR 51LEKTYSAQDL KVLSVSETPV KGIYEVVVSG RQIIYTDAEG GYMFVGELIN 101 IDTRKNLTEERAADLNKIDF ASLPLDKAIK EVRGNGKLKV AVFSDPDCPF 151 CKRLEHEFEK MTDVTVYSFMMPIAGLHPDA ARKAQILWCQ PDRAKAWTDW 201 MRKGKFPVGG SICDNPVAET TSLGEQFGFNGTPTLVFPNG RSQSGYSPMP 251 QLEEIIRKNQ *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m292/g292 98.7% identity in 238 aa overlap        10        20        30        40        50        60 m292.pepMKTKLIKILTPFTVLPLLACGQTPVSNANAEPAVKAESAGKSVAASLKARLEKTYSAQDL||||||||||||||||||||||||||||||| |||||||||||||||||||||||||||| g292MKTKLIKILTPFTVLPLLACGQTPVSNANAESAVKAESAGKSVAASLKARLEKTYSAQDL        10        20        30        40        50        60        70        80        90       100       110       120 m292.pepKVLSVSETPVKGIYEVVVSGRQIIYTDAEGGYMFVGELINIDTRKNLTEERAADLNKIDF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g292KVLSVSETPVKGIYEVVVSGRQIIYTDAEGGYMFVGELINIDTRKNLTEERAADLNKIDF        70        80        90       100       110       120       130       140       150       160       170       180 m292.pepASLPLDKAIKEVRGNGKLKVAVFSDPDCPFCKRLEHEFEKMTDVTVYSFMMPIAGLHPDA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g292ASLPLDKAIKEVRGNGKLKVAVFSDPDCPFCKRLEHEFEKMTDVTVYSFMMPIAGLHPDA       130       140       150       160       170       180       190       200       210       220       230       240 m292.pepARKAQILWCQPDRAKAWTDWMRKGKFPVGGSICDNPVAETTSLGEQFGFNGTPTLVFPNG||||||||||||||||||||||||||||||||||||||||||||||||||||||| :|: g292ARKAQILWCQPDRAKAWTDWMRKGKFPVGGSICDNPVAETTSLGEQFGFNGTPTLRLPQR       190       200       210       220       230       240       250       260 m292.pep RSQSGYSPMPQLEEIIRKNQX g292AHPKRLQPDAPTGGNHPQKPAVNPQX        250       260The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1221>:

a292.seq 1 ATGAAAACCA AGTTAATCAA AATCTTGACC CCCTTTACCG TCCTCCCGCT 51GCTGGCTTGC GGGCAAACGC CCGTTTCCAA TGCCAACGCC GAACCCGCCG 101 TCAAAGCCGAGTCCGCCGGC AAATCCGTTG CCGCCTCTTT GAAAGCGCGT 151 TTGGAAAAAA CCTATTCCGCCCAAGATTTG AAAGTGTTGA GCGTCAGCGA 201 AACACCGGTC AAAGGCATTT ACGAAGTCGTCGTCAGCGGC AGGCAGATTA 251 TCTACACCGA TGCCGAAGGC GGCTATATGT TCGTCGGCGAACTCATCAAC 301 ATCGACACGC GCAAAAACCT GACCGAAGAA CGCGCCGCCG ATTTGAACAA351 AATCGACTTC GCCTCCCTGC CTTTGGACAA AGCCATCAAA GAAGTGCGCG 401GCAACGGCAA GCTGAAAGTC GCCGTCTTCT CCGACCCCGA TTGTCCGTTC 451 TGCAAACGCTTGGAACACGA GTTTGAAAAA ATGACCGACG TGACGGTTTA 501 CAGCTTTATG ATGCCCATTGCCGGCCTGCA CCCCGATGCC GCGCGCAAGG 551 CGCAAATCTT ATGGTGTCAG CCCGACCGCGCCAAAGCGTG GACGGATTGG 601 ATGCGTAAAG GCAAATTCCC GGTCGGCGGC AGCATCTGCGACAATCCCGT 651 CGCGGAAACC ACTTCCTTGG GCGAACAATT CGGCTTCAAC GGCACGCCGA701 CCCTCGTCTT CCCCAACGGG CGCAGCCAAA GCGGCTACAG CCCGATGCCC 751CAACTGGAGG AAATCATCCG CAAAAATCAA TAAThis corresponds to the amino acid sequence <SEQ ID 1222; ORF 292.a>:

a292.pep 1 MKTKLIKILT PFTVLPLLAC GQTPVSNANA EPAVKAESAG KSVAASLKAR 51LEKTYSAQDL KVLSVSETPV KGIYEVVVSG RQIIYTDAEG GYMFVGELIN 101 IDTRKNLTEERAADLNKIDF ASLPLDKAIK EVRGNGKLKV AVFSDPDCPF 151 CKRLEHEFEK MTDVTVYSFMMPIAGLHPDA ARKAQILWCQ PDRAKAWTDW 201 MRKGKFPVGG SICDNPVAET TSLGEQFGFNGTPTLVFPNG RSQSGYSPMP 251 QLEEIIRKNQ * m292/a292 100.0% identity in 260aa overlap         10        20        30        40        50        60m292.pep MKTKLIKILTPFTVLPLLACGQTPVSNANAEPAVKAESAGKSVAASLKARLEKTYSAQDL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a292MKTKLIKILTPFTVLPLLACGQTPVSNANAEPAVKAESAGKSVAASLKARLEKTYSAQDL        10        20        30        40        50        60        70        80        90       100       110       120 m292.pepKVLSVSETPVKGIYEVVVSGRQIIYTDAEGGYMFVGELINIDTRKNLTEERAADLNKIDF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a292KVLSVSETPVKGIYEVVVSGRQIIYTDAEGGYMFVGELINIDTRKNLTEERAADLNKIDF        70        80        90       100       110       120       130       140       150       160       170       180 m292.pepASLPLDKAIKEVRGNGKLKVAVFSDPDCPFCKRLEHEFEKMTDVTVYSFMMPIAGLHPDA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a292ASLPLDKAIKEVRGNGKLKVAVFSDPDCPFCKRLEHEFEKMTDVTVYSFMMPIAGLHPDA       130       140       150       160       170       180       190       200       210       220       230       240 m292.pepARKAQILWCQPDRAKAWTDWMRKGKFPVGGSICDNPVAETTSLGEQFGFNGTPTLVFPNG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a292ARKAQILWCQPDRAKAWTDWMRKGKFPVGGSICDNPVAETTSLGEQFGFNGTPTLVFPNG       190       200       210       220       230       240       250       260 m292.pep RSQSGYSPMPQLEEIIRKNQX||||||||||||||||||||| a292 RSQSGYSPMPQLEEIIRKNQX        250       260The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1223>:

g294.seq (partial) 1 atgcgtatta cctgtgcgcc gatgtcgctt ttgtcggcggcagtctggtc 51 ggttcgggct gtcagaacat catcgaaccg ctttcctgcg gcgttacgac 101gatattcggc ttttcgacct acaatttttc cgaagcctgc cggcacgcct 151 tggcatcgggtgcggcggtt caagtcgaat cggcggacgc gtggcgtgaa 201 gccgttgaaa aaaccttatctggcgagggg ggcggaatgc agatgcaggc 251 gcgcgtggac ggctttatcg cacaacatcgcggagcgggc gcgagaatcg 301 ccgaggcggt gcgggaagcg gtatgcggac atcgggggcgatagtgatac 351 aatccgtatc cgagttttcc ggttggagca tcgtatgagt atttatgccg401 tcgcgcacat catccacctg tattgcgcca ccgcctttgt cggcggcgtg 451ttttttgaag tgctggtttt gtccgtcctg catacgggac gggtgtcgcg 501 cgaggcgcggcgcgaagtgg aaaaggcaat gtcttaccgc gccgtcaggg 551 tgatgccgtt tgcggtcggactgctgttcg ccaggggaac tctagagtcg 601 actgcagcag catgccctc...This corresponds to the amino acid sequence <SEQ ID 1224; ORF 294.ng>:

g294.pep (partial) 1 MRITCAPMSL LSAAVWSVRA VRTSSNRFPA ALRRYSAFRPTIFPKPAGTP 51 WHRVRRFKSN RRTRGVKPLK KPYLARGAEC RCRRAWTALS HNIAERARES 101PRRCGKRYAD IGGDSDTIRI RVFRLEHRMS IYAVAHIIHL YCATAFVGGV 151 FFEVLVLSVLHTGRVSREAR REVEKAMSYR AVRVMPFAVG LLFARGTLES 201 TAAACP....The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1225>:

m294.seq 1 ATGCGTATTA CCTGTGCGCC GATGTCGCTT TTGTCGGCGG CAGTCTGGTC 51GATTCGGGTT GTCAGAACAT CATCGAACCG CTTTCCTGCG GCGTTCCGAC 101 GATATTCGGCTTTTCAACCT ACAATTTTTC CGAAGCCTGC CGACACGCCT 151 TGGCATCGGG TGCGGCGGTTCAAGTCGAAT CGGCGGATGC GTGGCGGGAA 201 GCCGTTGAAA AAACCTTATC GTCCGAGGGGGGGGGGATGC AGATGCAGGC 251 GCGCGTGGAC GGCTTTATCG CACAACATCG CGGAGCGGGCGCGAGAATCG 301 CCGAGGCGGT GCGGGAAGCG GTATGCGGAT ATCGGGGGCG ATAGTGATAC351 AATCCGTATC CGAGTTTTCC GTTTGGAGCA TCGTATGAGT ATTTATGCCG 401TCGCGCACAT CGTTCATCTG TATTGCGCTA TTGCCTTTGT CGGCGGCGTG 451 TTTTTTGAAGTGCTGGTTTT GTCCGTCCTG CATACGGGAC GGGTGTCGCG 501 CGAGGCGCGG CGCGAAGTGGAAAAGGCAAT GTCTTACCGC GCCGTCAGGG 551 TGATGCCGTT TGTGGTCGGA CTGCTGTTCGCCAGCGGCAT CGTGATGGCG 601 GCAAACCGCT ATCTTTCTAT ATTGGGCGAA CCGTTTGCCACTTCCTTCGG 651 TACGATGCTG ACGCTGAAAA TCCTGTTGGC GTTCAGCGTA TTGGCGCACT701 TCGCCATCGC CGTCGTCAAA ATGGCGCGTT CCACACTGAC GGTCGGTTGG 751TCGAAATACA TACACGCCGT CGTCTTTACC CATATGcTGC TGATTGTCTT 801 TTTGGCAAAAGCGATGTTTT ATATCAGCTG GTAAThis corresponds to the amino acid sequence <SEQ ID 1226; ORF 294>:

m294.pep 1 MRITCAPMSL LSAAVWSIRV VRTSSNRFPA AFRRYSAFQP TIFPKPADTP 51WHRVRRFKSN RRMRGGKPLK KPYRPRGGGC RCRRAWTALS HNIAERARES 101 PRRCGKRYADIGGDSDTIRI RVFRLEHRMS IYAVAHIVHL YCAIAFVGGV 151 FFEVLVLSVL HTGRVSREARREVEKAMSYR AVRVMPFVVG LLFASGIVMA 201 ANRYLSILGEPFATSFGTML TLKILLAFSV LAHFAIAVVK MARSTLTVGW 251SKYIHAVVFT HMLLIVFLAK AMFYISW* g294/m294 92.3% identity in 196 aaoverlap         10        20        30        40        50        60g294.pep MRITCAPMSLLSAAVWSVRAVRTSSNRFPAALRRYSAFRPTIFPKPAGTPWHRVRRFKSN|||||||||||||||||:|:|||||||||||:||||||:|||||||| ||||||||||| m294MRITCAPMSLLSAAVWSIRVVRTSSNRFPAAFRRYSAFQPTIFPKPADTPWHRVRRFKSN        10        20        30        40        50        60        70        80        90       100       110       120 g294.pepRRTRGVKPLKKPYLARGAECRCRRAWTALSHNIAERARESPRRCGKRYADIGGDSDTIRI|| || |||||||  ||: ||||||||||||||||||||||||||||||||||||||||| m294RRMRGGKPLKKPYRPRGGGCRCRRAWTALSHNIAERARESPRRCGKRYADIGGDSDTIRI        70        80        90       100       110       120       130       140       150       160       170       180 g294.pepRVFRLEHRMSIYAVAHIIHLYCATAFVGGVFFEVLVLSVLHTGRVSREARREVEKAMSYR|||||||||||||||||:||||| |||||||||||||||||||||||||||||||||||| m294RVFRLEHRMSIYAVAHIVHLYCAIAFVGGVFFEVLVLSVLHTGRVSREARREVEKAMSYR       130       140       150       160       170       180       190       200 g294.pep AVRVMPFAVGLLFARGTLESTAAACP|||||||:|||||| | m294AVRVMPFVVGLLFASGIVMAANRYLSILGEPFATSFGTMLTLKILLAFSVLAHFAIAVVK       190       200       210       220       230       240The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1227>:

a294.seq 1 ATGCGTATTA CCTGTGCGCC GATGTCGCTT TTGTCGGCGG CAGTCTGGTC 51GATTCGGGCT GTCAGAACAT CATCGAACCG CTTTCCTGCG GCGTTCCGAC 101 GATATTCGGCTTTTCGACCT ACAATTTTTC CGAAGCCTGC CGGCACGCCT 151 TGGCATCGGG TGCGGCGGTTCAAGTCGAAT CGGCGGACGC GTGGCGGGAA 201 GCCGTTGAAA AAAACTTATC GTCCGAGGAGGGCGGAATGC AGATGCAGGC 251 GCGCGCGGAC GGCTTTATCG CACAACATCG CGGAGCGGGCGCGAGAATCG 301 CCGAGGCGGT ACGGGAAGCG GTATGCGGAC ATCGGGGACG ATAGTGATAC351 AATCCGTATC CGAGTTTTCC GGTTGGAGTA CCGTATGAGT ATTTATGCCG 401TCGCGCACAT CGTCCACCTG TATTGCGCCA TCGCCTTTGT CGGCGGCGTG 451 TTTTTTGAAGTGCTGGTTTT GTCCGTCCTG CATACGGGAC GGGTGTCGTG 501 CGAGGCGCGG CGCGAAGTGGAAAAGGCAAT GTCTTACCGC GCCGTCAGGG 551 TGATGCCGTT TGTGGTCGGA CTGCTGTTCGCCAGCGGCAT CGTGATGGCG 601 GCAAACCGCT ATCTTTCTAT ATTGGGCGAA CCGTTTGCCACTTCCTTCGG 651 TACGATGCTG ACGCTGAAAA TCCTGTTGGC GTTCAGCGTG TTGGCGCACT701 TCGCCATCGC CGTCGTCAAA ATGGCGCGTT CCACACTGAC CGTCGGCTGG 751TCGAAATACA TACACACCGT CGTCTTTACC CATATGCTGC TGATTGTCTT 801 TTTGGCAAAAGCGATGTTTT ATATCAGCTG GTAAThis corresponds to the amino acid sequence <SEQ ID 1228; ORF 294.a>:

a294.pep 1 MRITCAPMSL LSAAVWSIRA VRTSSNRFPA AFRRYSAFRP TIFPKPAGTP 51WHRVRRFKSN RRTRGGKPLK KTYRPRRAEC RCRRARTALS HNIAERARES 101 PRRYGKRYADIGDDSDTIRI RVFRLEYRMS IYAVAHIVHL YCAIAFVGGV 151 FFEVLVLSVL HTGRVSCEARREVEKAMSYR AVRVMPFVVG LLFASGIVMA 201 ANRYLSILGE PFATSFGTMLTLKILLAFSV LAHFAIAVVK MARSTLTVGW 251 SKYIHTVVFT HMLLIVFLAK AMFYISW*m294/a294 94.9% identity in 277 aa overlap        10        20        30        40        50        60 m294.pepMRITCAPMSLLSAAVWSIRVVRTSSNRFPAAFRRYSAFQPTIFPKPADTPWHRVRRFKSN|||||||||||||||||||:||||||||||||||||||:|||||||| |||||||||||| a294MRITCAPMSLLSAAVWSIRAVRTSSNRFPAAFRRYSAFRPTIFPKPAGTPWHRVRRFKSN        10        20        30        40        50        60        70        80        90       100       110       120 m294.pepRRMRGGKPLKKPYRPRGGGCRCRRAWTALSHNIAERARESPRRCGKRYADIGGDSDTIRI|| |||||||| |||| : |||||| ||||||||||||||||| |||||||| ||||||| a294RRTRGGKPLKKTYRPRRAECRCRRARTALSHNIAERARESPRRYGKRYADIGDDSDTIRI        70        80        90       100       110       120       130       140       150       160       170       180 m294.pepRVFRLEHRMSIYAVAHIVHLYCAIAFVGGVFFEVLVLSVLHTGRVSREARREVEKAMSYR||||||:||||||||||||||||||||||||||||||||||||||| ||||||||||||| a294RVFRLEYRMSIYAVAHIVHLYCAIAFVGGVFFEVLVLSVLHTGRVSCEARREVEKAMSYR       130       140       150       160       170       180       190       200       210       220       230       240 m294.pepAVRVMPFVVGLLFASGIVMAANRYLSILGEPFATSFGTMLTLKILLAFSVLAHFAIAVVK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a294AVRVMPFVVGLLFASGIVMAANRYLSILGEPFATSFGTMLTLKILLAFSVLAHFAIAVVK       190       200       210       220       230       240       250       260       270 m294.pepMARSTLTVGWSKYIHAVVFTHMLLIVFLAKAMFYISWX|||||||||||||||:|||||||||||||||||||||| a294MARSTLTVGWSKYIHTVVFTHMLLIVFLAKAMFYISWX        250       260       270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1229>:

g295.seq 1 atgctcggga tggcgcggca cgacggccag cagggcatcg ccgcgatatt 51gttgccacgc cgccagcagt ttttccgcct cgtcttcgcc ccgataaacg 101 cgcgtgctgccgcacacggc aaccggccgg cctccgatgc gtttttcaaa 151 ctgccccgcc agcgttttcatgtcttcaga cggcatcagg tcgtatttgg 201 tattgccgca cacctgcacg gatgccgcgcccaatttcgc caaccgcgcc 251 gcatccgcct ccgtctgcgc cagacagccc gtcagcgaagcggctgcggg 301 acggatcagg cggcggactt tcagataacc gttcagcgat ttttccgaca351 gccgcgcatt cgccaaaaac agcggcacac ccgctcgccg gcattccttc 401atcagattgg gccagatttc ggtttccatc aaaatgccga acatcgggcg 451 gtgttcgcgcaaaaactgcc gtacccacgt ttttttgtca tacggaagat 501 agcggcattg cgcatcgggaaacagaactt gcgcggtttc ccgtcccgtc 551 ggggtcatct gcgtcatcag cagcggcgcatcgggaaaac gccgccgcaa 601 ctcgcgtatc aagggctggg cggcacgcgt ttctccgaccgaaacggcgt 651 gtatccaaac cgcgccggta acgggattcg gatgcggctt gccgaaacgc701 tcgtccctat gcgcccggta tgccggggca cttccggagc gtttgtccaa 751ataacgccgt atccatatcg gcgcaagcag ccacaataca tcataaagcc 801 attggaacatctttctattt cctgcaaaac aaatgccgtc cgaacggttc 851 ggacggcatt tcggcaacggaatcaaatat cgtagThis corresponds to the amino acid sequence <SEQ ID 1230; ORF 295.ng>:

g295.pep 1 MLGMARHDGQ QGIAAILLPR RQQFFRLVFA PINARAAAHG NRPASDAFFK 51LPRQRFHVFR RHQVVFGIAA HLHGCRAQFR QPRRIRLRLR QTARQRSGCG 101 TDQAADFQITVQRFFRQPRI RQKQRHTRSP AFLHQIGPDF GFHQNAEHRA 151 VFAQKLPYPR FFVIRKIAALRIGKQNLRGF PSRRGHLRHQ QRRIGKTPPQ 201 LAYQGLGGTR FSDRNGVYPN RAGNGIRMRLAETLVPMRPV CRGTSGAFVQ 251 ITPYPYRRKQ PQYIIKPLEH LSISCKTNAV RTVRTAFRQRNQIS*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1231>:

m295.seq 1 ATGCTCGGGA TGGCGCGGCA CGACGACCAG CAGCGCATCG CCGCGATATT 51GTTGCCACGC CGCCAGCAGT TTTTCCGCCT CGTCTTCACC CCGATAAACG 101 CGCGTGCTGCCGCACACGGC AACCGGCCGG CCTCCGATGC GTTTTTCAAA 151 CTGCCCCGCC AGCGTTTTCATCTGTTCCGA CGGTATGATG TCGTATTTGG 201 TATTGCCGCA CACCTGCACG GATGCCGCGCCCAATTTCGC CAACCGCGCC 251 GCATCCGCCT CTGTCTGCGC CAGACACCCC GTCAGCGAAGCGGCGGCAGG 301 ACGGATCAGG CGGCGGACTT TCAGATAACC GTTCAACGAT TTTTCCGACA351 GCCGCGCATT CGCCAAAAAC AGCGGCACAC CCGCGCGCCG GCATTCCCTC 401ATCAGGTTGG GCCAGATTTC GGTTTCCATC AAAATGCCGA ACATCGGGCG 451 GTGTTCGCGCAAAAACTGCC GTACCCACGT TTTTTTGTCA TACGGAAGAT 501 AGCGGCATTG CGCATCGGGAAACAGAACTT GCGCGGTTTC CCGCCCCGTC 551 GGGGTCATCT GCGTCATCAG CAGCGGCGCATCGGGAAAAC GCCGCCGCAA 601 CTCGCGTATC AAGGACTGGG CGGCACGCGT TTCTCCGACCGAAACGGCGT 651 GTATCCAAAC CGCGCCGGTA ACGGGATTCG GATACGGCTT GCCGAAACGC701 TCGTCCCGAT GCGCCCGATA TGCCGGGGCA CTTCCGGAGC GTTTGTCCAA 751ATAACGCCGT ATCCATATCG GCGCAAGCAG CCACAATACA TCATAAAGCC 801 ATTGGAACATCTTTCTATTT CCTGCAAAAC AAATGCCGTC TGAACGGTTC 851 AGACGGCATT TCGGCAACGGAATCAAATAT CGTAGThis corresponds to the amino acid sequence <SEQ ID 1232; ORF 295>:

m295.pep 1 MLGMARHDDQ QRIAAILLPR RQQFFRLVFT PINARAAAHG NRPASDAFFK 51LPRQRFHLFR RYDVVFGIAA HLHGCRAQFR QPRRIRLCLR QTPRQRSGGR 101 TDQAADFQITVQRFFRQPRI RQKQRHTRAP AFPHQVGPDF GFHQNAEHRA 151 VFAQKLPYPR FFVIRKIAALRIGKQNLRGF PPRRGHLRHQ QRRIGKTPPQ 201 LAYQGLGGTR FSDRNGVYPN RAGNGIRIRLAETLVPMRPI CRGTSGAFVQ 251 ITPYPYRRKQ PQYIIKPLEH LSISCKTNAV XTVQTAFRQRNQIS* m295/g295 93.9% identity in 294 aa overlap        10        20        30        40        50        60 m295.pepMLGMARHDDQQRIAAILLPRRQQFFRLVFLPINARAAAHGNRPASDAFFKLPRQRFHLFR|||||||| || |||||||||||||||||:|||||||||||||||||||||||||||:|| g295MLGMARHDGQQGIAAILLPRRQQFFRLVFAPINARAAAHGNRPASDAFFKLPRQRFHVFR        10        20        30        40        50        60        70        80        90       100       110       120 m295.pepRYDVVFGIAAHLHGCRAQFRQPRRIRLCLRQTPRQRSGGRTDQAADFQITVQRFFRQPRI|::|||||||||||||||||||||||| |||| |||||  |||||||||||||||||||| g295RHQVVFGIAAHLHGCRAQFRQPRRIRLRLRQTARQRSGCGTDQAADFQITVQRFFRQPRI        70        80        90       100       110       120       130       140       150       160       170       180 m295.pepRQKQRHTRAPAFPHQVGPDFGFHQNAEHRAVFAQKLPYPRFFVIRKIAALRIGKQNLRGF||||||||:||| ||:|||||||||||||||||||||||||||||||||||||||||||| g295RQKQRHTRSPAFLHQIGPDFGFHQNAEHRAVFAQKLPYPRFFVIRKIAALRIGKQNLRGF       130       140       150       160       170       180       190       200       210       220       230       240 m295.pepPPRRGHLRHQQRRIGKTPPQLAYQGLGGTRFSDRNGVYPNRAGNGIRIRLAELLVPMRPI| |||||||||||||||||||||||||||||||||||||||||||||:|||||||||||: g295PSRRGHLRHQQRRIGKTPPQLAYQGLGGTRFSDRNGVYPNRAGNGIRMRLAELLVPMRPV       190       200       210       220       230       240       250       260       270       280       290 m295.pepCRGTSGAFVQITPYPYRRKQPQYIIKPLEHLSISCKTNAVXTVQTAFRQRNQISX|||||||||||||||||||||||||||||||||||||||| ||:|||||||||| g295CRGTSGAFVQITPYPYRRKQPQYIIKPLEHLSISCKTNAVRTVRTAFRQRNQIS       250       260       270       280       290The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1233>:

a295.seq 1 ATGCTCGGGA TGGCGCGGCA CGACGACCAG CAGGGCATCG CCGCGATATT 51GTTGCCACGC CGCCAGCAGT TTTTCCGCCT CGTCTTCACC CCGATAAACG 101 CGCGTGCTGCCGCACACGGC AACCTGCCGG TCTCCGATGC GTTTTTCAAA 151 CTGCCCCGCC AGCGTTTTCATCTGTTCCGA CGGCATCAGG TCGTATTTGG 201 TATTGCCGCA CACCTGCACG GATGCCGCGCCCAATTTCGC CAACCGCGCC 251 GCATCCGCCT CCGTCTGTGC CAGACAGCCC GTCAGCGAAGCGGCGGCAGG 301 ACGGATCAGG CTGCGGACTT TCAGATAACC GTTTAGCGAT TTTTCCGACA351 GCCGCGCATT CGCCAAAAAC AGCGGCACAC CCGTGCGCCG GCATTCCTTC 401ATCAGATTGG GCCAGATTTC GGTTTCCATC AAAATGCCGA ACATCGGGCG 451 GTGTTCGCGCAAAAACTGCC GTACCCACGT TTTTTTGTCA TACGGAAGAT 501 AGCGGCATTG TGCATCAGGAAACAGAACTT GCGCGGTTTC CCGTCCCGTC 551 GGGGTCATCT GCGTCATCAG CAGCGGCGCATCGGGAAAAC GCTGCCGCAA 601 CTCGCGTATC AAAGGTTGGG CGGCACGCGT TTCCCCGACCGAAACGGCGT 651 GTATCCAAAC CGCGCCGGTA ACGGGATTCG GATACGGCTT GCCGAAACGC701 TCGCCCCGAT GCGCCCGATA TGCAGGGGCA CTTCCGGAGC GTTTGTCCAA 751ATAACGCCGT ATCCATATCG GCGCAAGCAG CCACAATACA TCATAAAGCC 801 ATTGGAACATCTTTCTATTT CCTGCAAAAC AAATGCCGTC CGAACGGTTC 851 GGACGGCATT TCGGCAACGGAATCAAATAT CGTAGThis corresponds to the amino acid sequence <SEQ ID 1234; ORF 295.a>:

a295.pep 1 MLGMARHDDQ QGIAAILLPR RQQFFRLVFT PINARAAAHG NLPVSDAFFK 51LPRQRFHLFR RHQVVFGIAA HLHGCRAQFR QPRRIRLRLC QTARQRSGGR 101 TDQAADFQITV*RFFRQPRI RQKQRHTRAP AFLHQIGPDF GFHQNAEHRA 151 VFAQKLPYPR FFVIRKIAALCIRKQNLRGF PSRRGHLRHQ QRRIGKTLPQ 201 LAYQRLGGTR FPDRNGVYPN RAGNGIRIRLAETLAPMRPI CRGTSGAFVQ 251 ITPYPYRRKQ PQYIIKPLEH LSISCKTNAV RTVRTAFRQRNQIS* m295/a295 93.2% identity in 294 aa overlap        10        20        30        40        50        60 m295.pepMLGMARHDDQQRIAAILLPRRQQFFRLVFTPINARAAAHGNRPASDAFFKLPRQRFHLFR||||||||||| ||||||||||||||||||||||||||||| |:|||||||||||||||| a295MLGMARHDDQQGIAAILLPRRQQFFRLVFTPINARAAAHGNLPVSDAFFKLPRQRFHLFR        10        20        30        40        50        60        70        80        90       100       110       120 m295.pepRYDVVFGIAAHLHGCRAQFRQPRRIRLCLRQTPRQRSGGRTDQAADFQITVQRFFRQPRI|::|||||||||||||||||||||||| | || |||||||||||||||||| |||||||| a295RHQVVFGIAAHLHGCRAQFRQPRRIRLRLCQTARQRSGGRTDQAADFQITVXRFFRQPRI        70        80        90       100       110       120       130       140       150       160       170       180 m295.pepRQKQRHTRAPAFPHQVGPDFGFHQNAEHRAVFAQKLPYPRFFVIRKIAALRIGKQNLRGF|||||||||||| ||:|||||||||||||||||||||||||||||||||| | ||||||| a295RQKQRHTRAPAFLHQIGPDFGFHQNAEHRAVFAQKLPYPRFFVIRKIAALCIRKQNLRGF       130       140       150       160       170       180       190       200       210       220       230       240 m295.pepPPRRGHLRHQQRRIGKTPPQLAYQGLGGTRFSDRNGVYPNRAGNGIRIRLAETLVPMRPI| ||||||||||||||| |||||| |||||| ||||||||||||||||||||||:||||| a295PSRRGHLRHQQRRIGKTLPQLAYQRLGGTRFPDRNGVYPNRAGNGIRIRLAETLAPMRPI       190       200       210       220       230       240       250       260       270       280       290 m295.pepCRGTSGAFVQITPYPYRRKQPQYIIKPLEHLSISCKTNAVXTVQTAFRQRNQISX|||||||||||||||||||||||||||||||||||||||| ||:||||||||||| a295CRGTSGAFVQITPYPYRRKQPQYIIKPLEHLSISCKTNAVRTVRTAFRQRNQISX       250       260       270       280       290The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1235>:

g297.seq 1 ATGGCTGTCT TCCCACTTTC GGCAAAACAT CGGAAATACG CGCTGCGCGC 51GCTTGCCGTT TCGATTATTC TGGTGtcgGC GGCATACATT GCttcgacag 101 aggggaccgagcgcgtcaga ccgcAGCGCG TggaacaaAA ACTGCCGCCG 151 CTGTCtTGGg gcggcaacggCGTtcagacg gcaTATTGGG TGCAGGAGGC 201 GGTGCagccg ggggactcgC TGGCGGACGTGCTGGCGCGT TCGGGTATGG 251 CGCGGGacga gattgCCcga ATcacGGAAA aataTggcgGCGAAGCCGAT 301 TTGCGgcatt tGCGTGCCGA CCAGTCGGTT CATGTTTTGG TCGGCGGCGA351 CGGCAGTGCG CGCGAAGTGC AGTTTTttaC CGACGAAGAC GGCGAGCGCA 401aTctGGTCGC TTTGGAAAAA AAAGGCGGCA TATGGCGGCG GTCGGCTTCT 451 GATGCGGATATGAAGGTTTT GCCGACACTG CGTTCGGTCG TGGTCAAAAC 501 GTCGGCGCGC GGTTCGCTGGCGCGGGCGGA AGTGCCCGTC GAAATCCGCG 551 AATCCTTAAG CGGGATTTTT GCCGGCCGCTTCAGCCTTGA CGGTTTGAAG 601 GAAGGCGATG CCGTGCGCCT GCTTTACGAC AGCCTGTATTTCCACGGGCA 651 GCAGGTGGCG GCGGGCGATA TTTTGGCGGC GGAAGTTGTC AAGGGCGGCA701 CAACCCATCA GGCGTTCTAT TACCGTTCGG ACAAGGAAGG CGGAGGGGGC 751GGCAATTATT ACGATGAAGA CGGCAGGGTG TTGCAGGAAA AAGGCGGCTT 801 CAACATCgaGCCGCTGGTCT ATACGCGCAT TTCTTCGCCG TTCGGCTACC 851 GTATGCACCC CATCCTGCACACATGGCGGC TGCACACGGG CATCGATTAT 901 GCCGCACCGC AGGGAACGCC GGTCAGGGCTTCCGCCGACG GCGTGATTAC 951 CTTTAAAGGC CGGAAGGGCG GATACGGCAA CGCGGTGATGATACGCCACG 1001 CCAACGGTGT GGAAACGCTG TACGCGCACT TGAGCGCGTT TTCGCAGGCA1051 CAAGGCAATG TGCGCGGCGG CGAGGTCATC GGTTTTGTCG GTTCGACAGG 1101GCGTTCGACC GGGCCGCACC TGCATTACGA GGCGCGCATC AACGGGCAGC 1151 CCGTCAATCCTGTTTCGGTC GCATTGCCGA CACCCGAATT GACGCAGGCG 1201 GACAAGGCGG CGTTTGCCGCGCAGAAACAG AAGGCGGACG CGCTGCTTGC 1251 GCGCTTGCGC GGCATACCGG TTACCGTGTCGCAATCGGAT TGAThis corresponds to the amino acid sequence <SEQ ID 1236; ORF 297.ng>:

g297.pep 1 MAVFPLSAKH RKYALRALAV SIILVSAAYI ASTEGTERVR PQRVEQKLPP 51LSWGGNGVQT AYWVQEAVQP GDSLADVLAR SGMARDEIAR ITEKYGGEAD 101 LRHLRADQSVHVLVGGDGSA REVQFFTDED GERNLVALEK KGGIWRRSAS 151 DADMKVLPTL RSVVVKTSARGSLARAEVPV EIRESLSGIF AGRFSLDGLK 201 EGDAVRLLYD SLYFHGQQVA AGDILAAEVVKGGTTHQAFY YRSDKEGGGG 251 GNYYDEDGRV LQEKGGFNIE PLVYTRISSP FGYRMHPILHTWRLHTGIDY 301 AAPQGTPVRA SADGVITFKG RKGGYGNAVM IRHANGVETL YAHLSAFSQA351 QGNVRGGEVI GFVGSTGRST GPHLHYEARI NGQPVNPVSV ALPTPELTQA 401DKAAFAAQKQ KADALLARLR GIPVTVSQSD *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1237>:

m297.seq 1 ATGGCTGTCT TCCCACTTTC GGCAAAACAT CGGAAATACG CGCTGCGTGC 51GCTTGCCGTT TCGATTATTT TGGTGTCGGC GGCATACATT GCTTCGACAG 101 AGAGGACGGAGCGCGTCAGA CCGCAGCGCG TGGAACAAAA TCTGCCGCCG 151 CTGTCTTGGG GCGGCAGCGGCGTTCAGACG GCATATTGGG TGCAGGAGGC 201 GGTGCAGCCG GGCGACTCGC TGGCGGACGTGCTGGCGCGT TCGGGTATGG 251 CGCGGGACGA GATTGCCCGA ATCACGGAAA AATATGGCGGCGAAGCCGAT 301 TTGCGGCATT TGCGTGCCGA CCAGTCGGTT CATGTTTTGG TCGGCGGCGA351 CGGCGGCGCG CGCGAAGTGC AGTTTTTTAC CGACGAAGAC GGCGAGCGCA 401ATCTGGTCGC TTTGGAAAAG AAAGGCGGCA TATGGCGGCG GTCGGCTTCT 451 GAGGCGGATATGAAGGTTTT GCCGACGCTG CGTTCGGTCG TGGTCAAAAC 501 GTCGGCGCGC GGTTCGCTGGCGCGGGCGGA AGTGCCCGTC GAAATCCGCG 551 AATCCTTAAG CGGGATTTTC GCCGGCCGCTTCAGCCTTGA CGGTTTGAAG 601 GAAGGCGATG CCGTGCGCCT GATGTACGAC AGCCTGTATTTCCACGGGCA 651 GCAGGTGGCG GCGGGCGATA TTTTGGCGGC TGAAGTCGTT AAGGGCGGCA701 CAAGGCATCA GGCGTTCTAT TACCGTTCGG ACAAGGAAGG CGGAGGGGGC 751GGCAATTATT ATGATGAAGA CGGCAAGGTG TTGCAGGAAA AAGGCGGCTT 801 CAACATCGAGCCGCTGGTCT ATACGCGCAT TTCTTCGCCG TTCGGCTACC 851 GTATGCACCC CATCCTGCACACATGGCGGC TGCACACGGG CATCGATTAT 901 GCCGCACCGC AGGGAACGCC GGTCAGGGCTTCCGCCGACG GCGTGATTAC 951 CTTTAAAGGC CGGAAGGGCG GATACGGCAA CGCGGTGATGATACGCCACG 1001 CCAACGGTGT GGAAACGCTG TACGCGCACT TGAGCGCGTT TTCGCAGGCG1051 GAAGGCAATG TGCGCGGCGG CGAGGTCATC GGTTTTGTCG GTTCGACCGG 1101GCGTTCGACC GGGCCGCACC TGCATTACGA GGCGCGCATC AACGGGCAGC 1151 CCGTCAATCCTGTTTCGGTC GCATTGCCGA CACCGGAATT GACGCAGGCG 1201 GACAAGGCGG CGTTTGCCGCGCAGAAACAG AAGGCGGACG CGCTGCTTGC 1251 GCGCTTGCGC GGCATACCGG TTACCGTGTCGCAATCGGAT TGAThis corresponds to the amino acid sequence <SEQ ID 1238; ORF 297>:

m297.pep 1 MAVFPLSAKH RKYALRALAV SIILVSAAYI ASTERTERVR PQRVEQNLPP 51LSWGGSGVQT AYWVQEAVQP GDSLADVLAR SGMARDEIAR ITEKYGGEAD 101 LRHLRADQSVHVLVGGDGGA REVQFFTDED GERNLVALEK KGGIWRRSAS 151 EADMKVLPTL RSVVVKTSARGSLARAEVPV EIRESLSGIF AGRFSLDGLK 201 EGDAVRLMYD SLYFHGQQVA AGDILAAEVVKGGTRHQAFY YRSDKEGGGG 251 GNYYDEDGKV LQEKGGFNIE PLVYTRISSP FGYRMHPILHTWRLHTGIDY 301 AAPQGTPVRA SADGVITFKG RKGGYGNAVM IRHANGVETL YAHLSAFSQA351 EGNVRGGEVI GFVGSTGRST GPHLHYEARI NGQPVNPVSV ALPTPELTQA 401DKAAFAAQKQ KADALLARLR GIPVTVSQSD * m297/g297 97.9% identity in 430 aaoverlap         10        20        30        40        50        60m297.pep MAVFPLSAKHRKYALRALAVSIILVSAAYIASTERTERVRPQRVEQNLPPLSWGGSGVQT|||||||||||||||||||||||||||||||||| |||||||||||:||||||||:|||| g297MAVFPLSAKHRKYALRALAVSIILVSAAYIASTEGTERVRPQRVEQKLPPLSWGGNGVQT        10        20        30        40        50        60        70        80        90       100       110       120 m297.pepAYWVQEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGGA||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:| g297AYWVQEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGSA        70        80        90       100       110       120       130       140       150       160       170       180 m297.pepREVQFFTDEDGERNLVALEKKGGIWRRSASEADMKVLPTLRSVVVKTSARGSLARAEVPV||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||| g297REVQFFTDEDGERNLVALEKKGGIWRRSASDADMKVLPTLRSVVVKTSARGSLARAEVPV       130       140       150       160       170       180       190       200       210       220       230       240 m297.pepEIRESLSGIFAGRFSLDGLKEGDAVRLMYDSLYFHGQQVAAGDILAAEVVKGGTRHQAFY|||||||||||||||||||||||||||:|||||||||||||||||||||||||| ||||| g297EIRESLSGIFAGRFSLDGLKEGDAVRLLYDSLYFHGQQVAAGDILAAEVVKGGLTHQAFY       190       200       210       220       230       240       250       260       270       280       290       300 m297.pepYRSDKEGGGGGNYYDEDGKVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTGIDY||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||| g297YRSDKEGGGGGNYYDEDGRVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTGIDY       250       260       270       280       290       300       310       320       330       340       350       360 m297.pepAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFSQAEGNVRGGEVI||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| g297AAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFSQAQGNVRGGEVI       310       320       330       340       350       360       370       380       390       400       410       420 m297.pepGFVGSTGRSTGPHLHYEARINGQPVNPVSVALPTPELTQADKAAFAAQKQKADALLARLR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g297GFVGSTGRSTGPHLHYEARINGQPVNPVSVALPTPELTQADKAAFAAQKQKADALLARLR       370       380       390       400       410       420        430m297.pep GIPVTVSQSDX ||||||||||| g297 GIPVTVSQSDX        430The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1239>:

a297.seq 1 ATGGCTGTCT TCCCACTTTC GGCAAAACAT CGGAAATACG CGCTGCGCGC 51GCTTGCCGTT TCGATTATTT TGGTGTCGGC GGCATACATT GCTTCGACAG 101 AGAGGACGGAGCGCGTCAGA CCGCAGCGCG TGGAACAAAA ACTGCCGCCG 151 CTGTCTTGGG GCGGCAGCGGTGTTCAGACG GCATATTGGG TGCAGGAGGC 201 GGTGCAGCCA GGCGACTCGC TGGCGGACGTGCTGGCGCGT TCGGGTATGG 251 CGCGGGACGA AATTGCCCGA ATAACGGAAA AATATGGCGGCGAAGCCGAT 301 TTGCGGCATT TGCGTGCCGA CCAGTCGGTT CATGTTTTGG TCGGCGGCGA351 CGGCGGCGCG CGCGAAGTGC AGTTTTTTAC CGACGAAGAC GGCGAGCGCA 401ATCTGGTCGC TTTGGAAAAA AAAGGCGGCA TATGGCGGCG GTCGGCTTCT 451 GAGGCGGATATGAAGGTTTT GCCGACGCTG CGTTCGGTCG TGGTCAAAAC 501 GTCGGCGCGC GGTTCGCTGGCGCGGGCGGA AGTGCCCGTC GAAATTCGCG 551 AATCCTTAAG CGGGATTTTC GCCGGCCGCTTCAGCCTTGA TGGTTTGAAG 601 GAAGGCGATG CCGTGCGCCT GATTTACGAC AGCCTGTATTTCCACGGGCA 651 GCAGGTGGCG GCGGGCGATA TTCTGGCGGC GGAAGTCGTT AAGGGCGGCA701 CAAGGCATCA GGCGTTCTAT TACCGTTCGG ACAAGGAAGG AGGAGGGGGC 751GGCAATTATT ACGATGAAGA CGGCAGGGTG TTGCAGGAAA AAGGCGGCTT 801 CAACATCGAGCCACTGGTCT ATACGCGCAT TTCTTCGCCG TTCGGCTACC 851 GTATGCACCC CATCCTGCACACTTGGCGGC TGCACACGGG CATCGATTAT 901 GCCGCACCGC AGGGAACGCC GGTCAGGGCTTCCGCCGACG GCGTGATTAC 951 CTTTAAAGGC CGGAAGGGTG GCTACGGCAA CGCGGTGATGATACGCCACG 1001 CCAACGGTGT GGAAACGCTG TATGCGCACT TGAGCGCGTT TTCTCAGGCA1051 GAAGGCAATG TGCGCGGCGG CGAGGTCATC GGTTTTGTCG GTTCGACCGG 1101GCGTTCGACG GGGCCGCACC TGCATTACGA GGCGCGCATC AATGGGCAGC 1151 CCGTCAATCCTGTTTCGGTC GCATTGCCGA CACCCGAATT GACGCAGGCG 1201 GACAAGGCGG CGTTTGCCGCGCAGAAACAG AAGGCGGACG CGCTGCTTGC 1251 GCGCTTGCGC GGCATACCGG TTACCGTGTCGCAATCGGAT TGAThis corresponds to the amino acid sequence <SEQ ID 1240; ORF 297.a>:

a297.pep 1 MAVFPLSAKH RKYALRALAV SIILVSAAYI ASTERTERVR PQRVEQKLPP 51LSWGGSGVQT AYWVQEAVQP GDSLADVLAR SGMARDEIAR ITEKYGGEAD 101 LRHLRADQSVHVLVGGDGGA REVQFFTDED GERNLVALEK KGGIWRRSAS 151 EADMKVLPTL RSVVVKTSARGSLARAEVPV EIRESLSGIF AGRFSLDGLK 201 EGDAVRLIYD SLYFHGQQVA AGDILAAEVVKGGTRHQAFY YRSDKEGGGG 251 GNYYDEDGRV LQEKGGFNIE PLVYTRISSP FGYRMHPILHTWRLHTGIDY 301 AAPQGTPVRA SADGVITFKG RKGGYGNAVM IRHANGVETL YAHLSAFSQA351 EGNVRGGEVI GFVGSTGRST GPHLHYEARI NGQPVNPVSV ALPTPELTQA 401DKAAFAAQKQ KADALLARLR GIPVTVSQSD * m297/a297 99.3% identity in 430 aaoverlap         10        20        30        40        50        60m297.pep MAVFPLSAKHRKYALRALAVSIILVSAAYIASTERTERVRPQRVEQNLPPLSWGGSGVQT||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||| a297MAVFPLSAKHRKYALRALAVSIILVSAAYIASTERTERVRPQRVEQKLPPLSWGGSGVQT        10        20        30        40        50        60        70        80        90       100       110       120 m297.pepAYWVQEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGGA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a297AYWVQEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGGA        70        80        90       100       110       120       130       140       150       160       170       180 m297.pepREVQFFTDEDGERNLVALEKKGGIWRRSASEADMKVLPTLRSVVVKTSARGSLARAEVPV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a297REVQFFTDEDGERNLVALEKKGGIWRRSASEADMKVLPTLRSVVVKTSARGSLARAEVPV       130       140       150       160       170       180       190       200       210       220       230       240 m297.pepEIRESLSGIFAGRFSLDGLKEGDAVRLMYDSLYFHGQQVAAGDILAAEVVKGGTRHQAFY|||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||| a297EIRESLSGIFAGRFSLDGLKEGDAVRLIYDSLYFHGQQVAAGDILAAEVVKGGTRHQAFY       190       200       210       220       230       240       250       260       270       280       290       300 m297.pepYRSDKEGGGGGNYYDEDGKVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTGIDY||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||| a297YRSDKEGGGGGNYYDEDGRVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTGIDY       250       260       270       280       290       300       310       320       330       340       350       360 m297.pepAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFSQAEGNVRGGEVI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a297AAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFSQAEGNVRGGEVI       310       320       330       340       350       360       370       380       390       400       410       420 m297.pepGFVGSTGRSTGPHLHYEARINGQPVNPVSVALPTPELTQADKAAFAAQKQKADALLARLR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a297GFVGSTGRSTGPHLHYEARINGQPVNPVSVALPTPELTQADKAAFAAQKQKADALLARLR       370       380       390       400       410       420        430m297.pep GIPVTVSQSDX ||||||||||| a297 GIPVTVSQSDX        430The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1241>:

g298.seq 1 ATGAAAAACT TTCTTTCCCT TTTCGCCTCC ATACTGATGT CTGCCCTGAT 51TGCCGTGTGG TTCAGCCAAA ACCCCATCAA CGCCTACTGG CAGCAGACCT 101 ACCACCGCAACAGCCCGCTC GAACCGCTTG CCGCCTACGG ATGGTGGCGG 151 AGCGGAGCGG CGTTGCAAGAAAACGCCTAC GCCCTTTCAG ACGGCATCAA 201 AACCTTCCTG TCCGGCGAAA cgccccccacggCTCAAGAC GGCGGTTCGG 251 CAGATATGCC GCCTGAAGCC GCCGCATCCG AAGCCGCCCCGCCGGCCGGC 301 GGAACAGAAT GGAAACAAGG CACCGAAGCC GCCGCCGTCC GCAGCGGCGA351 CAAAGTCTTT TTCGCCGGAG ATTCGCTGAT GCAGGGCGTT GCGCCTTTCG 401TGCAAAAAAG CCTGAAACAG CAATACGGCA TCGAATCCGC CAACCTCAGC 451 AAACAAAGCACGGGGCTTTC CTATCCCTCA TTCTTCGACT GGCCGAAAAC 501 GATTGAAGAA ACCTTGAAAAAACATCCCGA AATCAGCGTA CTCGCCGTCT 551 TCCTCGGCCC GAACGACCCG TGGGATTTCCCCGTCGGCAA ACGCTACCTC 601 AAATTCGCTT CCGACGAATG GGCGCAAGAA TACCTGAAACGCGTCGACCG 651 CATCCTTGAA GCCGCACACA CGCACCGCGT CCAAGTCGTC TGGCTCGGCA701 TCCCCTACAT GAAAAAAGTC AAGCTCGACG GTCAGATGCG CTACCTCGAC 751AAACTGCTTT CGGAACACTT GAAAGGCAAA ATCATCCTGA TTCCCACCGC 801 GCAAACACTGAGCGGCGGGA AAGgccGCTA CACCGATTCC GTCAACGTCA 851 ACGGCAAACC CGTCCGCTACCGCAGTAAGG ACGGCATACA CTTTACCGCC 901 GAAGGACAAA AACTGCTGGC GGAAAAAATAATGGAAAAAA TCGTTTTTGA 951 ACCGAGTACG CAACCATCAA GTACACAGCC ATGAThis corresponds to the amino acid sequence <SEQ ID 1242; ORF 298.ng>:

g298.pep 1 MKNFLSLFAS ILMSALIAVW FSQNPINAYW QQTYHRNSPL EPLAAYGWWR 51SGAALQENAY ALSDGIKTFL SGETPPTAQD GGSADMPPEA AASEAAPPAG 101 GTEWKQGTEAAAVRSGDKVF FAGDSLMQGV APFVQKSLKQ QYGIESANLS 151 KQSTGLSYPS FFDWPKTIEETLKKHPEISV LAVFLGPNDP WDFPVGKRYL 201 KFASDEWAQE YLKRVDRILE AAHTHRVQVVWLGIPYMKKV KLDGQMRYLD 251 KLLSEHLKGK IILIPTAQTL SGGKGRYTDS VNVNGKPVRYRSKDGIHFTA 301 EGQKLLAEKI MEKIVFEPST QPSSTQP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1243>:

m298.seq 1 ATGAAAAACT TTCTTTCCCT TTTCTCCTCC ATACTGATGT CTGCCCTGAT 51TGCCGTGTGG TTCAGCCAAA ACCCCATCAA CGCCTACTGG CAGCAGACCT 101 ACCACCGCAACAGCCCGCTC GAACCGCTTG CCGCCTACGG ATGGTGGCGG 151 AGCGGTGCGG CGTTGCAAGAAAACGCCTAC GCCCTTTCAG ACGGCATCAA 201 AGCCTTCCTG TCCGGCGAAA CGCCGCCGACGGCTCAAGAC GGCGGTTCGG 251 CAGATATGCC GTCTGAAGCC GCCGCATCCG AAGCCGTCCCTCAAACCGGT 301 GAAACAGAAT GGAAACAAGA CACCGAAGCC GCCGCCGTCC GCAGCGGCGA351 CAAAGTCTTT TTTGTCGGCG ACTCGCTGAT GCAGGGCGTT GCCCCCTTCG 401TGCAAAAAAG CCTGAAACAG CAATACGGCA TCGAATCCGT CAACCTCAGC 451 AAACAAAGCACGGGGCTGTC CTACCCCTCA TTCTTCGACT GGCCGAAAAC 501 GATTGAAGAA ACCCTGCAAAAACATCCCGA AATCAGCGTA CTCGCCGTCT 551 TCCTCGGACC GAACGACCCG TGGGATTTCCCCGTCGGCAA ACTCTATCTC 601 AAATTCGCTT CCGACGAATG GGCGCAAGAA TACCTGAAACGTGTCGACCG 651 CATCCTTGAA GCCGCACACA CGCACCGCGT CCAAGTCGTC TGGCTCGGCA701 TCCCCTACAT GAAAAAAGCC AAGCTCGACG GACAGATGCG CTACCTAGAC 751AAACTGCTTT CGGAACATTT GAAAGGCAAA ATCATCCTGA TTCCCACCAC 801 GCACACCCTGAGCGGCGGGA AAGACCGCTA CACCGACTCC GTCAACGTCA 851 ACGGCAAACC CGTCCGCTACCGCAGCAAGG ACGGCATACA CTTTACCGCC 901 GAAGGACAAA AACTGCTGGC GGCAAAAATAATGGAAAAAA TCGTTTTTGA 951 ACCAAGTACG CAACCATCAA GTACACAGCC ATGAThis corresponds to the amino acid sequence <SEQ ID 1244; ORF 298>:

m298.pep 1 MKNFLSLFSS ILMSALIAVW FSQNPINAYW QQTYHRNSPL EPLAAYGWWR 51SGAALQENAY ALSDGIKAFL SGETPPTAQD GGSADMPSEA AASEAVPQTG 101 ETEWKQDTEAAAVRSGDKVF FVGDSLMQGV APFVQKSLKQ QYGIESVNLS 151 KQSTGLSYPS FFDWPKTIEETLQKHPEISV LAVFLGPNDP WDFPVGKLYL 201 KFASDEWAQE YLKRVDRILE AAHTHRVQVVWLGIPYMKKA KLDGQMRYLD 251 KLLSEHLKGK IILIPTTHTL SGGKDRYTDS VNVNGKPVRYRSKDGIHFTA 301 EGQKLLAAKI MEKIVFEPST QPSSTQP* m298/g298 94.8% identityin 327 aa overlap        10        20        30        40        50        60 m298.pepMKNFLSLFSSILMSALIAVWFSQNPINAYWQQTYHRNSPLEPLAAYGWWRSGAALQENAY||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||| g298MKNFLSLFASILMSALIAVWFSQNPINAYWQQTYHRNSPLEPLAAYGWWRSGAALQENAY        10        20        30        40        50        60        70        80        90       100       110       120 m298.pepALSDGIKAFLSGETPPLAQDGGSADMPSEAAASEAVPQTGETEWKQDTEAAAVRSGDKVF|||||||:||||||||||||||||||| |||||||:| :| ||||| ||||||||||||| g298ALSDGIKTFLSGETPPLAQDGGSADMPPEAAASEAAPPAGGTEWKQGTEAAAVRSGDKVF        70        80        90       100       110       120       130       140       150       160       170       180 m298.pepFVGDSLMQGVAPFVQKSLKQQYGIESVNLSKQSTGLSYPSFFDWPKTIEETLQKHPEISV|:||||||||||||||||||||||||:|||||||||||||||||||||||||:||||||| g298FAGDSLMQGVAPFVQKSLKQQYGIESANLSKQSTGLSYPSFFDWPKTIEETLKKHPEISV       130       140       150       160       170       180       190       200       210       220       230       240 m298.pepLAVFLGPNDPWDFPVGKLYLKFASDEWAQEYLKRVDRILEAAHTHRVQVVWLGIPYMKKA||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||: g298LAVFLGPNDPWDFPVGKRYLKFASDEWAQEYLKRVDRILEAAHTHRVQVVWLGIPYMKKV       190       200       210       220       230       240       250       260       270       280       290       300 m298.pepKLDGQMRYLDKLLSEHLKGKIILIPTTHTLSGGKDRYTDSVNVNGKPVRYRSKDGIHFTA||||||||||||||||||||||||||::|||||| ||||||||||||||||||||||||| g298KLDGQMRYLDKLLSEHLKGKIILIPTAQTLSGGKGRYTDSVNVNGKPVRYRSKDGIHFTA       250       260       270       280       290       300       310       320 m298.pep EGQKLLAAKIMEKIVFEPSTQPSSTQPX||||||| |||||||||||||||||||| g298 EGQKLLAEKIMEKIVFEPSTQPSSTQPX       310       320The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1245>:

a298.seq 1 ATGAAAAACT TTCTTTCCCT TTTCGCCTCC ATACTGATGT CTGCCCTGAT 51TGCCGTGTGG TTCAGCCAAA ACCCCATCAA CGCCTACTGG CAGCAGACCT 101 ACCACCGCAACAGCCCGCTC GAACCGCTTG CCGCCTACGG ATGGTGGCGG 151 AGCGGTGCGG CATTGCAAGAAAACGCCTAC GCCCTTTCAG ACGGCATCAA 201 AGCCTTCCTG TCCGGCGAAA CGCCGCCGACGGCTCAAGAC GGCGGTTCGG 251 CAGATATGCC GTCTGAAGCC GCCGCACCCG AAACCGCCCCTCAAACTGGC 301 GAAACAGAAT GGAAACAAAA CACCGAAGCC GCCGCCGTCC GAACAGGGGA351 CAAAGTCTTT TTCGCCGGCG ACTCGCTGAT GCAGGGCGTT GCACCCTTCG 401TGCAAAAAAG CCTGAAACAG CAATACGGCA TCGAATCCGT CAACCTCAGC 451 AAACAAAGCACGGGGCTGTC CTACCCCTCA TTCTTCGACT GGCCGAAAAC 501 GATTGAAGAA ACCCTGAAAAAACATCCCGA AATCAGCGTG CTCGCCGTCT 551 TCCTCGGTCC GAACGACCCG TGGGATTTCCCCGTTGGCAA ACGCTACCTC 601 AAATTCGCTT CCGACGAATG GGCGCAAGAA TACCTGAAACGCGTCGACCG 651 CATCCTTGAA GCCGCACACA CGCACTACGT CCAAGTCGTC TGGCTCGGCA701 TCCCCTACAT GAAAAAAGCC AAGCTCGACG GACAGATGCG CTACCTAGAC 751AAACTGCTTT CGGAATATTT GAAAGGCAAA ATCATCCTGA TTCCCACCGC 801 GCACACCCTGAGCGGCGGGA AAGACCGCTA CACCGACTCC GTCAACGTCA 851 ACGGCAAACC CGTCCGCTACCGCAGCAAGG ACGGCATACA CTTTACCGCC 901 GAAGGACAAA AACTGCTGGC GGCAAAAATAATGGAAAAAA TCGTTTTTGA 951 ACCAAGTACG CAACCATCAA GTACACAGCC ATGAThis corresponds to the amino acid sequence <SEQ ID 1246; ORF 298.a>:

a298.pep 1 MKNFLSLFAS ILMSALIAVW FSQNPINAYW QQTYHRNSPL EPLAAYGWWR 51SGAALQENAY ALSDGIKAFL SGETPPTAQD GGSADMPSEA AAPETAPQTG 101 ETEWKQNTEAAAVRTGDKVF FAGDSLMQGV APFVQKSLKQ QYGIESVNLS 151 KQSTGLSYPS FFDWPKTIEETLKKHPEISV LAVFLGPNDP WDFPVGKRYL 201 KFASDEWAQE YLKRVDRILE AAHTHYVQVVWLGIPYMKKA KLDGQMRYLD 251 KLLSEYLKGK IILIPTAHTL SGGKDRYTDS VNVNGKPVRYRSKDGIHFTA 301 EGQKLLAAKI MEKIVFEPST QPSSTQP* m298/a298 96.3% identityin 327 aa overlap        10        20        30        40        50        60 m298.pepMKNFLSLFSSILMSALIAVWFSQNPINAYWQQTYHRNSPLEPLAAYGWWRSGAALQENAY||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||| a298MKNFLSLFASILMSALIAVWFSQNPINAYWQQTYHRNSPLEPLAAYGWWRSGAALQENAY        10        20        30        40        50        60        70        80        90       100       110       120 m298.pepALSDGIKAFLSGETPPTAQDGGSADMPSEAAASEAVPQTGETEWKQDTEAAAVRSGDKVF|||||||||||||||||||||||||||||||| |::||||||||||:|||||||:||||| a298ALSDGIKAFLSGETPPTAQDGGSADMPSEAAAPETAPQTGETEWKQNTEAAAVRTGDKVF        70        80        90       100       110       120       130       140       150       160       170       180 m298.pepFVGDSLMQGVAPFVQKSLKQQYGIESVNLSKQSTGLSYPSFFDWPKTIEETLQKHPEISV|:||||||||||||||||||||||||||||||||||||||||||||||||||:||||||| a298FAGDSLMQGVAPFVQKSLKQQYGIESVNLSKQSTGLSYPSFFDWPKTIEETLKKHPEISV       130       140       150       160       170       180       190       200       210       220       230       240 m298.pepLAVFLGPNDPWDFPVGKLYLKFASDEWAQEYLKRVDRILEAAHTHRVQVVWLGIPYMKKA||||||||||||||||| ||||||||||||||||||||||||||| |||||||||||||| a298LAVFLGPNDPWDFPVGKRYLKFASDEWAQEYLKRVDRILEAAHTHYVQVVWLGIPYMKKA       190       200       210       220       230       240       250       260       270       280       290       300 m298.pepKLDGQMRYLDKLLSEHLKGKIILIPTTHTLSGGKDRYTDSVNVNGKPVRYRSKDGIHFTA|||||||||||||||:||||||||||:||||||||||||||||||||||||||||||||| a298KLDGQMRYLDKLLSEYLKGKIILIPTAHTLSGGKDRYTDSVNVNGKPVRYRSKDGIHFTA       250       260       270       280       290       300       310       320 m298.pep EGQKLLAAKIMEKIVFEPSTQPSSTQPX|||||||||||||||||||||||||||| a298 EGQKLLAAKIMEKIVFEPSTQPSSTQPX       310       320The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1247>:

g299.seq 1 ATGAACCCCA AACACTTCAT CGCATTTTCC GCCCTGTTCG CCGCCACGCA 51GGCAGAAGCC CTGCCCGTCG CCTCCGTCAG CCCCGACACC GTTACCGTTT 101 CCCCGTCCGCCCCCTACACC GATACAAACG GGCTGCTGAC CGACTACGGC 151 AACGCCGCCG CCTCGCCTTGGATGAAAAAA CTCCGATCCG TCGCACAAGG 201 CAGCGGCGAG GCCTTCCGCA TCCTGCAAATCGGCGACTCG CATACCGCCG 251 GCGACTTCTT TACCGACGCC CTGCGCAAAC GCCTGCAAAAAACATGGGGC 301 GACGGCGGCA TAGGCTGGGT TTACCCCGCC AACGTCAAAG GGCAGCGCAT351 GGCGGCCGTC CGTCACAGCG GCAACTGGCA AAGCTTCACC AGCAGGAACA 401ATACCGGAGA TTTCCCGCTC GGCGGCATCC TCGCCCAAAC CGGCAGCGGC 451 GGCGGCATGACCCTGACCGC GTCTGACGGC AAAACCGGCA AACAGCGCGT 501 TTCCCTGTTT GCCAAACCGCTGCTCGCCGA ACAAACCCTG ACCGTCAACG 551 GCAACACCGT CTCCGCCAAC GGCGGCGGCTGGCAGGTACT GGATACGGGC 601 GCGGCACTGC CCCTGGCCAT ACAGACCGAA ATGCCGTGGGACATCGGCTT 651 CATCAACATC GAAAATCCCG CCGGCGGCAT TACCGTTTCC GCGATGGGCA701 TCAACGGCGC ACAATTGACC CAGTGGTCGA AATGGCGTGC CGACCGTATG 751AACGACCTTG CCCAAACCGG CGCCGATTTG GTTATCCTTT CCTACGGCAC 801 CAACGAAGCCTTCAACAACA ACATCGACAT TGCCGATACC GAACAAAAAT 851 GGCTGGATAC CGTCCGCCAAATCCGCGACA GCCTGCCCGC CGCCGGCATC 901 CTCATCATCG GCGCGCCCGA ATCCCTGAAAAACACGCTCG GCGTATGCGG 951 CACGCGCCCC GTCCTCCTGA CCGAAGTCCA ACAGATGCAGCGGCGCGTCG 1001 CCCGTCAGGG GCAGACGATG TTTTGGTCTT GGCAAAACGC AATGGGCGGC1051 ATATGCAGCA TGAAAAACTG GCTCAACCAA GGATGGGCCG CCAAAGACGG 1101CGTACACTTC TCCGCCCAAG GCTACCGGCG CGCGGCGGAA ATGCTTGCCG 1151 ACAGCCTCGAAGAACTCGTC CGCGCCGCCG CAATCAGGCA ATAAThis corresponds to the amino acid sequence <SEQ ID 1248; ORF 299.ng>:

g299.pep 1 MNPKHFIAFS ALFAATQAEA LPVASVSPDT VTVSPSAPYT DTNGLLTDYG 51NAAASPWMKK LRSVAQGSGE AFRILQIGDS HTAGDFFTDA LRKRLQKTWG 101 DGGIGWVYPANVKGQRMAAV RHSGNWQSFT SRNNTGDFPL GGILAQTGSG 151 GGMTLTASDG KTGKQRVSLFAKPLLAEQTL TVNGNTVSAN GGGWQVLDTG 201 AALPLAIQTE MPWDIGFINI ENPAGGITVSAMGINGAQLT QWSKWRADRM 251 NDLAQTGADL VILSYGTNEA FNNNIDIADT EQKWLDTVRQIRDSLPAAGI 301 LIIGAPESLK NTLGVCGTRP VLLTEVQQMQ RRVARQGQTM FWSWQNAMGG351 ICSMKNWLNQ GWAAKDGVHF SAQGYRRAAE MLADSLEELV RAAAIRQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1249>:

m299.seq 1 ATGAACCCCA AACACCTCAT CGCATTTTCC GCCCTATTCG CCGCCACGCA 51GGCAGAAGCC CTACCTGTCG CCTCCGTCAG CCTCGACACC GTTACCGTTT 101 CCCCGTCCGCCCCCTACACC GATACAAACG GGCTGCTGAC CGACTACGGC 151 AACGCCTCCG CCTCGCCTTGGATGAAAAAA CTCCAATCCG TCGCACAAGG 201 CAGCGGCGAG ACCTTCCGTA TCCTGCAAATCGGCGACTCG CATACCGCCG 251 GCGACTTCTT TACCGACAGC CTGCGCAAAC GCCTGCAAAAAACTTGGGGC 301 GACGGCGGCA TAGGCTGGGT TTACCCCGCC AACGTCAAAG GGCAGCGCAT351 GGCGGCCGTC CGGCACAACG GTAACTGGCA AAGCCTCACC AGCAGGAACA 401ACACCGGAGA CTTCCCGCTC GGCGGCATCC TCGCCCACAC CGGCAGCGGC 451 GGCAGCATGACCCTGACCGC ATCGGACGGC ATAGCAAGCA AGCAGCGCGT 501 TTCCCTGTTT GCCAAACCCCTGCTTGCCGA ACAAACCCTG ACCGTCAACG 551 GCAACACCGT CTCCGCCAAC GGCGGCGGCTGGCAGGTACT GGATACGGGC 601 GCGGCACTGC CCCTGACCAT ACACACCGAA ATGCCGTGGGACATCGGCTT 651 CATCAACATC GAAAATCCCG CCGGCGGCAT TACCGTTTCC GCGATGGGCA701 TCAACGGCGC ACAATTAACC CAGTGGTCGA AATGGCGTGC CGACCGTATG 751AACGACCTCG CCCAAACCGG CGCCGATTTG GTTATCCTTT CCTACGGCAC 801 CAACGAAGCTTTCAACAACA ACATCGACAT TGCCGACACC GAACAAAAAT 851 GGCTGGATAC CGTCCGCCAAATCCGCGACA GCCTGCCTGC CGCCGGCATC 901 CTCATCATCG GCGCACCCGA ATCCCTGAAAAACACGCTCG GCGTATGCGG 951 CACACGCCCC GTCCGCCTGA CCGAAGTCCA ACAGATGCAGCGGCGCGTCG 1001 CCCGTCAGGG GCAGACGATG TTCTGGTCTT GGCAAAACGC CATGGGCGGC1051 ATATGCAGCA TGAAAAACTG GCTCAACCAA GGATGGGCCG CCAAAGACGG 1101CGTACACTTC TCCGCCAAAG GCTACCGGCG CGCGGCGGAA ATGCTCGCCG 1151 ACAGCCTCGAAGAACTCGTC CGCTCCGCTG CAATCAGGCA ATAAThis corresponds to the amino acid sequence <SEQ ID 1250; ORF 299>:

m299.pep 1 MNPKHLIAFS ALFAATQAEA LPVASVSLDT VTVSPSAPYT DTNGLLTDYG 51NASASPWMKK LQSVAQGSGE TFRILQIGDS HTAGDFFTDS LRKRLQKTWG 101 DGGIGWVYPANVKGQRMAAV RHNGNWQSLT SRNNTGDFPL GGILAHTGSG 151 GSMTLTASDG IASKQRVSLFAKPLLAEQTL TVNGNTVSAN GGGWQVLDTG 201 AALPLTIHTE MPWDIGFINI ENPAGGITVSAMGINGAQLT QWSKWRADRM 251 NDLAQTGADL VILSYGTNEA FNNNIDIADT EQKWLDTVRQIRDSLPAAGI 301 LIIGAPESLK NTLGVCGTRP VRLTEVQQMQ RRVARQGQTM FWSWQNAMGG351 ICSMKNWLNQ GWAAKDGVHF SAKGYRRAAE MLADSLEELV RSAAIRQ* m299/g299 95.5%identity in 397 aa overlap        10        20        30        40        50        60 m299.pepMNPKHLIAFSALFAATQAEALPVASVSLDTVTVSPSAPYTDTNGLLTDYGNASASPWMKK|||||:||||||||||||||||||||| ||||||||||||||||||||||||:||||||| g299MNPKHFIAFSALFAATQAEALPVASVSPDTVTVSPSAPYTDTNGLLTDYGNAAASPWMKK        10        20        30        40        50        60        70        80        90       100       110       120 m299.pepLQSVAQGSGETFRILQIGDSHTAGDFFTDSLRKRLQKTWGDGGIGWVYPANVKGQRMAAV|:||||||||:||||||||||||||||||:|||||||||||||||||||||||||||||| g299LRSVAQGSGEAFRILQIGDSHTAGDFFTDALRKRLQKTWGDGGIGWVYPANVKGQRMAAV        70        80        90       100       110       120       130       140       150       160       170       180 m299.pepRHNGNWQSLTSRNNTGDFPLGGILAHTGSGGSMTLTASDGIASKQRVSLFAKPLLAEQTL||:|||||:||||||||||||||||:|||||:|||||||| ::||||||||||||||||| g299RHSGNWQSFTSRNNTGDFPLGGILAQTGSGGGMTLTASDGKTGKQRVSLFAKPLLAEQTL       130       140       150       160       170       180       190       200       210       220       230       240 m299.pepTVNGNTVSANGGGWQVLDTGAALPLTIHTEMPWDIGFINIENPAGGITVSAMGINGAQLT|||||||||||||||||||||||||:|:|||||||||||||||||||||||||||||||| g299TVNGNTVSANGGGWQVLDTGAALPLAIQTEMPWDIGFINIENPAGGITVSAMGINGAQLT       190       200       210       220       230       240       250       260       270       280       290       300 m299.pepQWSKWRADRMNDLAQTGADLVILSYGTNEAFNNNIDIADTEQKWLDTVRQIRDSLPAAGI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g299QWSKWRADRMNDLAQTGADLVILSYGTNEAFNNNIDIADTEQKWLDTVRQIRDSLPAAGI       250       260       270       280       290       300       310       320       330       340       350       360 m299.pepLIIGAPESLKNTLGVCGTRPVRLTEVQQMQRRVARQGQTMFWSWQNAMGGICSMKNWLNQ||||||||||||||||||||| |||||||||||||||||||||||||||||||||||||| g299LIIGAPESLKNTLGVCGTRPVLLTEVQQMQRRVARQGQTMFWSWQNAMGGICSMKNWLNQ       310       320       330       340       350       360       370       380       390 m299.pepGWAAKDGVHFSAKGYRRAAEMLADSLEELVRSAAIRQX||||||||||||:||||||||||||||||||:|||||| g299GWAAKDGVHFSAQGYRRAAEMLADSLEELVRAAAIRQX        370       380       390The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1251>:

a299.seq 1 ATGAACCCCA AACACCTCAT CGCATTTTCC GCCCTATTCG CCGCCACGCA 51GGCAGAAGCC CTACCTGTCG CCTCAGTCAG CCTCGACACC GTTACCGTTT 101 CCCCGTCCGCCCCCTACACC GATACAAACG GGCTGCTGAC CGACTACGGC 151 AACGCCTCCG CCTCGCCTTGGATGAAAAAA CTCCAATCCG TCGCACAAGG 201 CAGCGGCGAG ACCTTCCGTA TCCTGCAAATCGGCGACTCG CATACCGCCG 251 GCGACTTCTT TACCGACAGC CTGCGCAAAC GCCTACAAAAAACTTGGGGC 301 GACGGCGGCA TAGGCTGGGT TTACCCCGCC AACGTCAAAG GGCAGCGCAT351 GGCGGCCGTC CGGCACAACG GTAACTGGCA AAGCCTCACC AGCAGGAACA 401ACACCGGAGA CTTCCCGCTC GGCGGCATCC TCGCCCACAC CGGCAGCGGC 451 GGCAGCATGACCCTGACCGC ATCGGACGGC ATAGCAAGCA AGCAGCGCGT 501 TTCCCTGTTT GCCAAACCCCTGCTTGCCGA ACAAACCCTG ACCGTCAACG 551 GCAACACCGT CTCCGCCAAC GGCGGCGGCTGGCAGGTACT GGATACGGGC 601 GCGGCACTGC CCCTGACCAT ACACACCGAA ATGCCGTGGGACATCGGCTT 651 CATCAACATC GAAAATCCCG CCGGCGGCAT TACCGTTTCC GCGATGGGCA701 TCAACGGCGC ACAATTAACC CAGTGGTCGA AATGGCGTGC CGACCGTATG 751AACGACCTTG CCCAAACCGG CGCCGATCTA GTCATCCTTG CCTACGGTAC 801 CAACGAAGCCTTCGGCGACA ACATCGACAT TGCCGATACC GAACAGAAAT 851 GGCTGGATAC CGTCCGCCAAATCCGCGACA GCCTACCTGC CGCCGGCATC 901 CTCATCATCG GCGCGCCCGA ATCCCTGAAAAACACGCTCG GCGTATGCGG 951 CACACGCCCC GTCCGCCTGA CCGAAGTCCA ACAGATGCAGCGGCGCATCG 1001 CCCGTCAGGG GCAGACGATG TTCTGGTCTT GGCAAAACGC GATGGGCGGC1051 GTTTGCAGCA TGAAAAACTG GCTCAACCAC GGATGGGCCG CCAAAGACGG 1101CGTACACTTT TCCGCCAAAG GCTACCAACG GTCGGCGGAA ATGCTCGCCG 1151 ACAGCCTCGAAGAACTCGTC CGCTCCGCTG CAATCAGGCA ATAAThis corresponds to the amino acid sequence <SEQ ID 1252; ORF 299.a>:

a299.pep 1 MNPKHLIAFS ALFAATQAEA LPVASVSLDT VTVSPSAPYT DTNGLLTDYG 51NASASPWMKK LQSVAQGSGE TFRILQIGDS HTAGDFFTDS LRKRLQKTWG 101 DGGIGWVYPANVKGQRMAAV RHNGNWQSLT SRNNTGDFPL GGILAHTGSG 151 GSMTLTASDG IASKQRVSLFAKPLLAEQTL TVNGNTVSAN GGGWQVLDTG 201 AALPLTIHTE MPWDIGFINI ENPAGGITVSAMGINGAQLT QWSKWRADRM 251 NDLAQTGADL VILAYGTNEA FGDNIDIADT EQKWLDTVRQIRDSLPAAGI 301 LIIGAPESLK NTLGVCGTRP VRLTEVQQMQ RRIARQGQTM FWSWQNAMGG351 VCSMKNWLNH GWAAKDGVHF SAKGYQRSAE MLADSLEELV RSAAIRQ* m299/a299 98.0%identity in 397 aa overlap        10        20        30        40        50        60 m299.pepMNPKHLIAFSALFAATQAEALPVASVSLDTVTVSPSAPYTDTNGLLTDYGNASASPWMKK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a299MNPKHLIAFSALFAATQAEALPVASVSLDTVTVSPSAPYTDTNGLLTDYGNASASPWMKK        10        20        30        40        50        60        70        80        90       100       110       120 m299.pepLQSVAQGSGETFRILQIGDSHTAGDFFTDSLRKRLQKTWGDGGIGWVYPANVKGQRMAAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a299LQSVAQGSGETFRILQIGDSHTAGDFFTDSLRKRLQKTWGDGGIGWVYPANVKGQRMAAV        70        80        90       100       110       120       130       140       150       160       170       180 m299.pepRHNGNWQSLTSRNNTGDFPLGGILAHTGSGGSMTLTASDGIASKQRVSLFAKPLLAEQTL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a299RHNGNWQSLTSRNNTGDFPLGGILAHTGSGGSMTLTASDGIASKQRVSLFAKPLLAEQTL       130       140       150       160       170       180       190       200       210       220       230       240 m299.pepTVNGNTVSANGGGWQVLDTGAALPLTIHTEMPWDIGFINIENPAGGITVSAMGINGAQLT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a299TVNGNTVSANGGGWQVLDTGAALPLTIHTEMPWDIGFINIENPAGGITVSAMGINGAQLT       190       200       210       220       230       240       250       260       270       280       290       300 m299.pepQWSKWRADRMNDLAQTGADLVILSYGTNEAFNNNIDIADTEQKWLDTVRQIRDSLPAAGI|||||||||||||||||||||||:|||||||::||||||||||||||||||||||||||| a299QWSKWRADRMNDLAQTGADLVILAYGTNEAFGDNIDIADTEQKWLDTVRQIRDSLPAAGI       250       260       270       280       290       300       310       320       330       340       350       360 m299.pepLIIGAPESLKNTLGVCGTRPVRLTEVQQMQRRVARQGQTMFWSWQNAMGGICSMKNWLNQ||||||||||||||||||||||||||||||||:|||||||||||||||||:||||||||: a299LIIGAPESLKNTLGVCGTRPVRLTEVQQMQRRIARQGQTMFWSWQNAMGGVCSMKNWLNH       310       320       330       340       350       360       370       380       390 m299.pepGWAAKDGVHFSAKGYRRAAEMLADSLEELVRSAAIRQX|||||||||||||||:|:|||||||||||||||||||| a299GWAAKDGVHFSAKGYQRSAEMLADSLEELVRSAAIRQX        370       380       390The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1253>:

g302.seq 1 ATGCACTCAA TATATTTTTT TAAGGAGAAG CAGATGAGTC AAACCGACGC 51GCGTCGTAGC GGACGATTTT TACGCACAGT CGAATGGCTG GGCAATATGT 101 TGCCGCACCCGGTTACGCTT TTTATTATTT TCATTGTGTT ATTGCTGATT 151 GCCTCTGCCG TCGGTGCGTATTTCGGACTA TCCGTCCCCG ATCCGCGTCC 201 TGTTGGGGCG AAAGGACGTG CCGATGACGGTTTGATTCAC GTTGTCAGCC 251 TGCTCGATGC CGACGGTTTG ATCAAAATCC TGACGCATACCGTTAAAAAT 301 TTCACCGGTT TCGCGCCGTT GGGAACGGTG TTGGTTTCTT TATTGGGCGT351 GGGGATTGCG GAAAAATCGG GCTTGATTTC CGCATTAATG CGCTTATTGC 401TCACAAAATC CCCACGCAAA CTCACTACTT TTATGGTTGT TTTTACAGGG 451 ATTTTATCCAATACGGCTTC TGAATTGGGC TATGTCGTCC TAATCCCTTT 501 GTCCGCCGTC ATCTTTCATTCGCTCGGCCG CCATCCGCTT GCCGGTTTGG 551 CTGCGGCTTT CGCCGGCGTT TCGGGCGGTTATTCGGCCAA TCTGTTCTTA 601 GGCACAATCG ATCCGCTCTT GGCAGGCATC ACCCAACAGGCGGCGCAAAT 651 CATCCATCCC GACTACGTCG TAGGCCCTGA AGCCAACTGG TTTTTTATGG701 CAGCCAGTAC GTTTGTGATT GCTTTGATTG GTTATTTTGT TACTGAAAAA 751ATCGTCGAAC CGCAATTGGG CCCTTATCAA TCAGATTTGT CACAAGAAGA 801 AAAAGACATTCGGCATTCCA ATGAAATCAC GCCTTTGGAA TATAAAGGAT 851 TAATTTGGGC AGGCGTGGTGTTTGTTGCCT TATCCGCCCT ATTGGCTTGG 901 AGCATCGTCC CTGCCGACGG TATTTTGCGTCATCCTGAAA CAGGATTGGT 951 TGCCGGTTCG CCGTTTTTAA AATCGATTGT TGTTTTTATTTTCTTGTTGT 1001 TTGCGCTGCC GGGCATTGTT TATGGCCGGA TAACCCGAAG TTTGCGCGGC1051 GAACGGGAAG TCGTTAATGC GATGGCCGAA TCGATGAGTA CTTTGGGACT 1101TTATTTGGTC ATCATCTTTT TTGCCGCACA GTTTGTCGCA TTTTTTAATT 1151 GGACGAATATTGGGCAATAT ATTGCCGTTA AAGGGGCGGT GTTCTTAAAA 1201 GAAGTCGGCT TGGGCGGCAGTGTGTTGTTT ATCGGTTTTA TTTTAATTTG 1251 TGCTTTTATC AATCTGATGA TAGGCTCCGCCTCCGCGCAA TGGGCGGTAA 1301 CTGCGCCGAT TTTCGTCCCT ATGCTGATGT TGGCCGGCTACGCGCCCCAA 1351 GTCATTCAAG CCGCTTACCG CATCGGTGAT TCCGTTACCA ATATTATTAC1401 GCCGATGATG AGTTATTTCG GGCTGATTAT GGCGACGGTA ATCAAATACA 1451AAAAAGATGC GGGCGTAGGC ACGCTGATTT CTATGATGTT GCCGTATTCC 1501 GCTTTCTTCTTAATTGCATG GATCGCCTTA TTCTGCATTT GGGTATTTGT 1551 TTTGGGTCTG CCCGTCGGTCCCGGCACACC CACATTCTAT CCGGTGCCTT 1601 AAThis corresponds to the amino acid sequence <SEQ ID 1254; ORF 302.ng>:

g302.pep 1 MHSIYFFKEK QMSQTDARRS GRFLRTVEWL GNMLPHPVTL FIIFIVLLLI 51ASAVGAYFGL SVPDPRPVGA KGRADDGLIH VVSLLDADGL IKILTHTVKN 101FTGFAPLGTV LVSLLGVGIA EKSGLISALM RLLLTKSPRK LTTFMVVFTG 151ILSNTASELG YVVLIPLSAV IFHSLGRHPL AGLAAAFAGV SGGYSANLFL 201 GTIDPLLAGITQQAAQIIHP DYVVGPEANW FFMAASTFVI ALIGYFVTEK 251 IVEPQLGPYQ SDLSQEEKDIRHSNEITPLE YKGLIWAGVV FVALSALLAW 301 SIVPADGILR HPETGLVAGSPFLKSIVVFI FLLFALPGIV YGRITRSLRG 351 EREVVNAMAESMSTLGLYLV IIFFAAQFVA FFNWTNIGQY IAVKGAVFLK 401EVGLGGSVLF IGFILICAFI NLMIGSASAQ WAVTAPIFVP MLMLAGYAPQ 451 VIQAAYRIGDSVTNIITPMM SYFGLIMATV IKYKKDAGVG TLISMMLPYS 501 AFFLIAWIAL FCIWVFVLGLPVGPGTPTFY PVP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1255>:

m302.seq 1 ATGCACTCAA TATATTTTTT TAAGGAGAAG CAGATGAGTC AAACCGATAC 51GCAACGGGAC GGACGATTTT TACGCACAGT CGAATGGCTG GGCAATATGT 101 TGCCGCATCCGGTTACGCTT TTTATTATTT TCATTGTGTT ATTGCTGATT 151 GCCTCTGCCG TCGGTGCGTATTTCGGACTA TCCGTCCCCG ATCCGCGCCC 201 TGTTGGTGCG AAAGGACGTG CCGATGACGGTTTGATTTAC ATTGTCAGCC 251 TGCTCAATGC CGACGGTTTT ATCAAAATCC TGACGCATACCGTTAAAAAT 301 TTCACCGGTT TCGCGCCGTT GGGAACGGTG TTGGTTTCTT TATTGGGCGT351 GGGGATTGCG GAAAAATCGG GCTTGATTTC CGCATTAATG CGCTTATTGC 401TCACAAAATC GCCACGCAAA CTCACTACTT TTATGGTTGT TTTTACAGGG 451 ATTTTATCTAATACCGCTTC TGAATTGGGC TATGTCGTCC TAATCCCTTT 501 GTCCGCCATC ATCTTTCATTCCCTCGGCCG CCATCCGCTT GCCGGTCTGG 551 CTGCGGCTTT CGCCGGCGTT TCGGGCGGTTATTCGGCCAA TCTGTTCTTA 601 AGCACAATCG ATCCGCTCTT GGCATGCATC ACCCATCAGGCGGCGGTCGT 651 AGGCCCTGAA GCCAACTGGT TTTTTATGGT AGCCAGTACG TTTGTGATTG701 CTTTGATTGG TTATTTTGTT ACTGAAAAAA TCGTCGAACC GCAATTGGGC 751CCTTATCAAT CAGATTTGTC ACAAGAAGAA AAAGACATTC GGCATTCCAA 801 TGAAATCACGCCTTTGGAAT ATAAAGGATT AATTTGGGCT GGCGTGGTGT 851 TTGTTGCCTT ATCCGCCCTATTGGCTTGGA GCATCGTCCC TGCCGACGGT 901 ATTTTGCGTC ATCCTGAAAC AGGATTGGTTTCCGGTTCGC CGTTTTTAAA 951 ATCGATTGTT GTTTTTATTT TCTTGTTGTT TGCACTGyCGGGCmTTGTTT 1001 ATGGmCGGGT AACAGGAAGT TTGCGCGGCG AACAGGAAGT CGTTAATGCG1051 ATGGCCGAAT CGATGAGTAC TCTGGsGCTT TmTTTGswCA kcATCTTTTT 1101TGCCGCACAG TTTGTCGCAT TTTTTAATTG GACGAATATT GGGCAATATA 1151 TTGCCGTTAAAGGGGCGACG TTCTTAAAAG AAGTCGGCTT GGGCGGCAGC 1201 GTGTTGTTTA TCGGTTTTATTTTAATTTGT GCTTTTATCA ATCTGATGAT 1251 AGGCTCCGCC TCCGCGCAAT GGGCGGTAACTGCGCCGATT TTCGTCCCTA 1301 TGCTGATGTT GGCCGGCTAC GCGCCCGAAG TCATTCAAGCCGCTTACCGC 1351 ATCGGTGATT CCGTTACCAA TATTATTACG CCGATGATGA GTTATTTCGG1401 GCTGATTATG GCGACGGTGA TCAAATACAA AAAAGATGCG GGCGTGGGTA 1451CGCTGATTTC TATGATGTTG CCGTATTCCG CTTTCTTCTT GATTGCGTGG 1501 ATTGCCTTATTCTGCATTTG GGTATTTGTT TTGGGCCTGC CCGTCGGTCC 1551 CGGCGCGCCC ACATTCTATCCCGCACCTTA AThis corresponds to the amino acid sequence <SEQ ID 1256; ORF 302>:

m302.pep 1 MHSIYFFKEK QMSQTDTQRD GRFLRTVEWL GNMLPHPVTL FIIFIVLLLI 51ASAVGAYFGL SVPDPRPVGA KGRADDGLIY IVSLLNADGF IKILTHTVKN 101FTGFAPLGTV LVSLLGVGIA EKSGLISALM RLLLTKSPRK LTTFMVVFTG 151ILSNTASELG YVVLIPLSAI IFHSLGRHPL AGLAAAFAGV SGGYSANLFL 201 STIDPLLACITHQAAVVGPE ANWFFMVAST FVIALIGYFV TEKIVEPQLG 251 PYQSDLSQEE KDIRHSNEITPLEYKGLIWA GVVFVALSAL LAWSIVPADG 301 ILRHPETGLVSGSPFLKSIV VFIFLLFALX GXVYGRVTRS LRGEQEVVNA 351MAESMSTLXL XLXXIFFAAQ FVAFFNWTNI GQYIAVKGAT FLKEVGLGGS 401VLFIGFILIC AFINLMIGSA SAQWAVTAPI FVPMLMLAGY APEVIQAAYR 451IGDSVTNIIT PMMSYFGLIM ATVIKYKKDA GVGTLISMML PYSAFFLIAW 501IALFCIWVFV LGLPVGPGAP TFYPAP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae ORF 302 shows 94.0%identity over a 533 aa overlap with a predicted ORF (ORF 302.ng) from N.gonorrhoeae:

m362/g302         10        20        30        40        50        60m302.pep MHSIYFFKEKQMSQTDTQRDGRFLRTVEWLGNMLPHPVTLFIIFIVLLLIASAVGAYFGL||||||||||||||||::|:|||||||||||||||||||||||||||||||||||||||| g302MHSIYFFKEKQMSQTDARRSGRFLRTVEWLGNMLPHPVTLFIIFIVLLLIASAVGAYFGL        10        20        30        40        50        60        70        80        90       100       110       120 m302.pepSVPDPRPVGAKGRADDGLIYIVSLLNADGFIKILTHTVKNFTGFAPLGTVLVSLLGVGIA|||||||||||||||||||::||||:|||:|||||||||||||||||||||||||||||| g302SVPDPRPVGAKGRADDGLIHVVSLLDADGLIKILTHTVKNFTGFAPLGTVLVSLLGVGIA        70        80        90       100       110       120       130       140       150       160       170       180 m302.pepEKSGLISALMRLLLTKSPRKLTTFMVVFTGILSNTASELGYVVLIPLSAIIFHSLGRHPL|||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||| g302EKSGLISALMRLLLTKSPRKLTTFMVVFTGILSNTASELGYVVLIPLSAVIFHSLGRHPL       130       140       150       160       170       180       190       200       210              220       230 m302.pepAGLAAAFAGVSGGYSANLFLSTIDPLLACITHQAA-------VVGPEANWFFMVASTFVI||||||||||||||||||||:||||||| ||:|||       |||||||||||:|||||| g302AGLAAAFAGVSGGYSANLFLGTIDPLLAGITQQAAQIIHPDYVVGPEANWFFMAASTFVI       190       200       210       220       230       240    240       250       260       270       280       290 m302.pepALIGYFVTEKIVEPQLGPYQSDLSQEEKDIRHSNEITPLEYKGLIWAGVVFVALSALLAW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g302ALIGYFVTEKIVEPQLGPYQSDLSQEEKDIRHSNEITPLEYKGLIWAGVVFVALSALLAW       250       260       270       280       290       300    300       310       320       330       340       350 m302.pepSIVPADGILRHPETGLVSGSPFLKSIVVFIFLLFALXGXVYGRVTRSLRGEQEVVNAMAE|||||||||||||||||:|||||||||||||||||| | ||||:|||||||:|||||||| g302SIVPADGILRHPETGLVAGSPFLKSIVVFIFLLFALPGIVYGRITRSLRGEREVVNAMAE       310       320       330       340       350       360    360       370       380       390       400       410 m302.pepSMSTLXLXLXXIFFAAQFVAFFNWTNIGQYIAVKGATFLKEVGLGGSVLFIGFILICAFI||||| | |  |||||||||||||||||||||||||:||||||||||||||||||||||| g302SMSTLGLYLVIIFFAAQFVAFFNWTNIGQYIAVKGAVFLKEVGLGGSVLFIGFILICAFI       370       380       390       400       410       420    420       430       440       450       460       470 m302.pepNLMIGSASAQWAVTAPIFVPMLMLAGYAPEVIQAAYRIGDSVTNIITPMMSYFGLIMATV|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| g302NLMIGSASAQWAVTAPIFVPMLMLAGYAPQVIQAAYRIGDSVTNIITPMMSYFGLIMATV       430       440       450       460       470       480    480       490       500       510       520 m302.pepIKYKKDAGVGTLISMMLPYSAFFLIAWIALFCIWVFVLGLPVGPGAPTFYPAPX|||||||||||||||||||||||||||||||||||||||||||||:|||||:|| g302IKYKKDAGVGILISMMLPYSAFFLIAWIALFCIWVFVLGLPVGPGIPTFYPVPX       490       500       510       520       530The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1257>:

a302.seq 1 ATGCACTCAA TATATTTTTT TAAGGAGAAG CAGATGAGTC AAACCGATAC 51GCAACGGGAC GGACGATTTT TACGCACAGT CGAATGGCTG GGCAATATGT 101 TGCCGCACCCGGTTACGCTT TTTATTATTT TCATTGTGTT ATTGCTGATT 151 GCCTCTGCCG CCGGTGCGTATTTCGGACTA TCCGTCCCCG ATCCGCGCCC 201 TGTTGGTGCG AAAGGACGTG CCGATGACGGTTTGATTCAC GTTGTCAGCC 251 TGCTCGATGC TGACGGTTTG ATCAAAATCC TGACGCATACCGTTAAAAAT 301 TTCACCGGTT TCGCGCCGTT GGGAACGGTG TTGGTTTCTT TATTGGGCGT351 GGGGATTGCG GAAAAATCGG GCTTGATTTC CGCATTAATG CGCTTATTGC 401TCACAAAATC TCCACGCAAA CTCACTACTT TTATGGTTGT TTTTACAGGG 451 ATTTTATCTAATACCGCTTC TGAATTGGGC TATGTCGTCC TAATCCCTTT 501 GTCCGCCATC ATCTTTCATTCCCTCGGCCG CCATCCGCTT GCCGGTCTGG 551 CTGCGGCTTT CGCCGGCGTT TCGGGCGGTTATTCGGCCAA TCTGTTCTTA 601 GGCACAATCG ATCCGCTCTT GGCAGGCATC ACCCAACAGGCGGCGCAAAT 651 CATCCATCCC GACTACGTCG TAGGCCCTGA AGCCAACTGG TTTTTTATGG701 TAGCCAGTAC GTTTGTGATT GCTTTGATTG GTTATTTTGT TACTGAAAAA 751ATCGTCGAAC CGCAATTGGG CCCTTATCAA TCAGATTTGT CACAAGAAGA 801 AAAAGACATTCGACATTCCA ATGAAATCAC GCCTTTGGAA TATAAAGGAT 851 TAATTTGGGC TGGCGTGGTGTTTGTTGCCT TATCCGCCCT ATTGGCTTGG 901 AGCATCGTCC CTGCCGACGG TATTTTGCGTCATCCTGAAA CAGGATTGGT 951 TTCCGGTTCG CCGTTTTTAA AATCAATTGT TGTTTTTATTTTCTTGTTGT 1001 TTGCACTGCC GGGCATTGTT TATGGCCGGG TAACCCGAAG TTTGCGCGGC1051 GAACAGGAAG TCGTTAATGC GATGGCCGAA TCGATGAGTA CTCTGGGGCT 1101TTATTTGGTC ATCATCTTTT TTGCCGCACA GTTTGTCGCA TTTTTTAATT 1151 GGACGAATATTGGGCAATAT ATTGCCGTTA AAGGGGCGAC GTTCTTAAAA 1201 GAAGTCGGCT TGGGCGGCAGCGTGTTGTTT ATCGGTTTTA TTTTAATTTG 1251 TGCTTTTATC AATCTGATGA TAGGCTCCGCCTCCGCGCAA TGGGCGGTAA 1301 CTGCGCCGAT TTTCGTCCCT ATGCTGATGT TGGCCGGCTACGCGCCCGAA 1351 GTCATTCAAG CCGCTTACCG CATCGGTGAT TCCGTTACCA ATATTATTAC1401 GCCGATGATG AGTTATTTCG GGCTGATTAT GGCGACGGTG ATCAAATACA 1451AAAAAGATGC GGGCGTGGGT ACGCTGATTT CTATGATGTT GCCGTATTCC 1501 GCTTTCTTCTTGATTGCGTG GATTGCCTTA TTCTGCATTT GGGTATTTGT 1551 TTTGGGCCTG CCCGTCGGTCCCGGCGCGCC CACATTCTAT CCCGCACCTT 1601 AAThis corresponds to the amino acid sequence <SEQ ID 1258; ORF 302.a>:

a302.pep 1 MHSIYFFKEK QMSQTDTQRD GRFLRTVEWL GNMLPHPVTL FIIFIVLLLI 51ASAAGAYFGL SVPDPRPVGA KGRADDGLIH VVSLLDADGL IKILTHTVKN 101FTGFAPLGTV LVSLLGVGIA EKSGLISALM RLLLTKSPRK LTTFMVVFTG 151ILSNTASELG YVVLIPLSAI IFHSLGRHPL AGLAAAFAGV SGGYSANLFL 201 GTIDPLLAGITQQAAQIIHP DYVVGPEANW FFMVASTFVI ALIGYFVTEK 251 IVEPQLGPYQ SDLSQEEKDIRHSNEITPLE YKGLIWAGVV FVALSALLAW 301 SIVPADGILR HPETGLVSGSPFLKSIVVFI FLLFALPGIV YGRVTRSLRG 351 EQEVVNAMAESMSTLGLYLV IIFFAAQFVA FFNWTNIGQY IAVKGATFLK 401EVGLGGSVLF IGFILICAFI NLMIGSASAQ WAVTAPIFVP MLMLAGYAPE 451 VIQAAYRIGDSVTNIITPMM SYFGLIMATV IKYKKDAGVG TLISMMLPYS 501 AFFLIAWIAL FCIWVFVLGLPVGPGAPTFY PAP* m302/a302 96.1% identity in 533 aa overlap        10        20        30        40        50        60 m302.pepMHSIYFFKEKQMSQTDTQRDGRFLRTVEWLGNMLPHPVTLFIIFIVLLLIASAVGAYFGL|||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||| a302MHSIYFFKEKQMSQTDTQRDGRFLRIVEWLGNMLPHPVTLFIIFIVLLLIASAAGAYFGL        10        20        30        40        50        60        70        80        90       100       110       120 m302.pepSVPDPRPVGAKGRADDGLIYIVSLLNADGFIKILTHTVKNFTGFAPLGTVLVSLLGVGIA|||||||||||||||||||::||||:|||:|||||||||||||||||||||||||||||| a302SVPDPRPVGAKGRADDGLIHVVSLLDADGLIKILTHTVKNFTGFAPLGTVLVSLLGVGIA        70        80        90       100       110       120       130       140       150       160       170       180 m302.pepEKSGLISALMRLLLTKSPRKLTTFMVVFTGILSNTASELGYVVLIPLSAIIFHSLGRHPL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a302EKSGLISALMRLLLIKSPRKLITFMVVFIGILSNTASELGYVVLIPLSAIIFHSLGRHPL       130       140       150       160       170       180       190       200       210              220       230 m302.pepAGLAAAFAGVSGGYSANLFLSTIDPLLACITHQAA-------VVGPEANWFFMVASTFVI||||||||||||||||||||:||||||| ||:|||       |||||||||||||||||| a302AGLAAAFAGVSGGYSANLFLGTIDPLLAGITQQAAQIIHPDYVVGPEANWFFMVASTFVI       190       200       210       220       230       240    240       250       260       270       280       290 m302.pepALIGYFVTEKIVEPQLGPYQSDLSQEEKDIRHSNEITPLEYKGLIWAGVVFVALSALLAW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a302ALIGYFVTEKIVEPQLGPYQSDLSQEEKDIRHSNEITPLEYKGLIWAGVVFVALSALLAW       250       260       270       280       290       300    300       310       320       330       340       350 m302.pepSIVPADGILRHPETGLVSGSPFLKSIVVFIFLLFALXGXVYGRVTRSLRGEQEVVNAMAE|||||||||||||||||||||||||||||||||||| | ||||||||||||||||||||| a302SIVPADGILRHPETGLVSGSPFLKSIVVFIFLLFALPGIVYGRVIRSLRGEQEVVNAMAE       310       320       330       340       350       360    360       370       380       390       400       410 m302.pepSMSTLXLXLXXIFFAAQFVAFFNWTNIGQYIAVKGATFLKEVGLGGSVLFIGFILICAFI|||||| |  ||||||||||||||||||||||||||||||||||||||||||||||||| a302SMSTLGLYLVIIFFAAQFVAFFNWINIGQYIAVKGATFLKEVGLGGSVLFIGFILICAFI       370       380       390       400       410       420    420       430       440       450       460       470 m302.pepNLMIGSASAQWAVTAPIFVPMLMLAGYAPEVIQAAYRIGDSVTNIITPMMSYFGLIMATV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a302NLMIGSASAQWAVTAPIFVPMLMLAGYAPEVIQAAYRIGDSVTNIITPMMSYFGLIMATV       430       440       450       460       470       480    480       490       500       510       520 m302.pepIKYKKDAGVGILISMMLPYSAFFLIAWIALFCIWVFVLGLPVGPGAPTFYPAPX|||||||||||||||||||||||||||||||||||||||||||||||||||||| a302IKYKKDAGVGILISMMLPYSAFFLIAWIALFCIWVFVLGLPVGPGAPTFYPAPX       490       500       510       520       530The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1259>:

g305.seq 1 ATGGATTTTT TGATTGTCCT GAAAGCCCTG ATGATGGGCT TGGTAGAAGG 51TTTTACCGAA TTTTTACCGA TTTCCAGCAC CGGACATTTG ATTGTGTTCG 101 GCAATCTGATTGGTTTTCAC AGCAATCACA AGGTTTTTGA AATTGCCATC 151 CAGCTCGGTG CGGTTTTGGCGGTAGTGTTT GAATACCGGC AGCGTTTCAG 201 CAATGTGTTG CATGGCGTGG GAAAAGACCGGAAAGCCAAC CGTTTCGTCC 251 TCAATCTTGC CATTGCTTTT ATACCTGCCG CCGTGATGGGGCTGTTGTTC 301 GACAAACAAA TCAAAGAGTA TCTGTTTAAC CCCTTGAGTG TTGCAGTCAT351 GCTGGTTTTG GGCGGTTTTT TTATTTTGTG GGTGGAGAAA CGCCAAAGCC 401GAGCAGAGCC TAAAATTGCC GATGTTGATG CATTGCGTCC GATTGATGCG 451 TTGATGATCGGTGTTGCCCA AGTGTTTGCA CTGGTTCCGG GTACGTCCCG 501 TTCGGGCAGT ACGGTTATGGGCGGGATGCT TTGGGGAATC GAGCGGAAAA 551 CGGCAACGGA GTTTTCATTT TTCTTGGCCGTTCCGATGAT GGTTGCAGCA 601 ACGGCTTATG ATGTCCTGAA ACATTACCGA TTTTTCACCCTGCATGATGT 651 CGGTTTGATT TTGATAGGCT TTATTGCCGC TTTTGTTTCC GGTTTGGTAG701 CGGTTAAAGC ACTGCTGAAG TTTGTTTCCA AGAAAAACTA TATCCCGTTT 751GCCTATTACC GCATTGTTTT CGGCATTGTC ATCATAATAT TGTGGTTGTC 801 GGGCTGGATAAGTTGGGAAT GAThis corresponds to the amino acid sequence <SEQ ID 1260; ORF 305.ng>:

g305.pep 1 MDFLIVLKAL MMGLVEGFTE FLPISSTGHL IVFGNLIGFH SNHKVFEIAI 51QLGAVLAVVF EYRQRFSNVL HGVGKDRKAN RFVLNLAIAF IPAAVMGLLF 101 DKQIKEYLFNPLSVAVMLVL GGFFILWVEK RQSRAEPKIA DVDALRPIDA 151 LMIGVAQVFA LVPGTSRSGSTVMGGMLWGI ERKTATEFSF FLAVPMMVAA 201 TAYDVLKHYRFFTLHDVGLI LIGFIAAFVS GLVAVKALLK FVSKKNYIPF 251AYYRIVFGIV IIILWLSGWI SWE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1261>:

m305.seq (partial) 1 AtGGATTTTC TGATTGTCCT GAAAGCCCTG ATGATGGGCTTGGTAGAAGG 51 TTTTACCGAA TTTTTACCGA TTTCCAGCAC CGGACATTTG ATTGTGTTCG 101GCAATCTGAT TGGTTTTCAC AGCAATCACA AGGTTTTTGA AATTGCCATC 151 CAGCTCGGTGCAGTTTTGGC GGTAGTGTTT GAATACCGGC AACGTTTCAG 201 CAATGTGTTG CACGGCTTGGGAAAAGACCG GAAAGCCAAC CGCTTCGTCC 251 TTAATCTTGC CATTGCTTTT ATACCTGCCGCCGTGATGGG GCTGTTGTTC 301 GGCAwACAAA TCAAAGAGyA TCTGTTTAAC CCCTTGAGTGTTGCAGTCAT 351 GCTGGTTyTG GrCGGTTTTT yTATTTTGTG GGTGGAGAAA CGCCAAAGCC401 GAGCAGAGCC TAAAATTGCC GATGTTGATG CATTGCGTCC GATTGATGCC 451TTGATGATCG GCGTTGCCCA AGTGTTTGCA CTGGTTCCGG GTACGTCCCG 501 TTCGGGCAGTACGATTATGG GCGGGATGCT TTGGGGCATC GAACGGAAAA 551 CTGCGACAGA ATTCTCGTTTTTCTTGGCTG TGCCGATGAT GGTTGCCGCA 601 ACGGCTTATG ATGTCCTGAA ACATTACCGATTTTTCACCC TGCATGATGT 651 CGGTTTGATT CTGATAGGCT TTATTGCTGC CTTTGTTTCAGGCTTGGTAG 701 CGGTAAAAGC GTTGCTGAGG TTTGTTTCGG GTAC...This corresponds to the amino acid sequence <SEQ ID 1262; ORF 305>:

m305.pep (partial) 1 MDFLIVLKAL MMGLVEGFTE FLPISSTGHL IVFGNLIGFHSNHKVFEIAI 51 QLGAVLAVVF EYRQRFSNVL HGLGKDRKAN RFVLNLAIAF IPAAVMGLLF 101GXQIKEXLFN PLSVAVMLVL XGFXILWVEK RQSRAEPKIA DVDALRPIDA 151LMIGVAQVFA LVPGTSRSGS TIMGGMLWGI ERKTATEFSF FLAVPMMVAA 201 TAYDVLKHYRFFTLHDVGLI LIGFIAAFVS GLVAVKALLR FVSG...Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae ORF 305 shows 96.7%identity over a 243 aa overlap with a predicted ORF (ORF 305.ng) from N.gonorrhoeae:

g305/m305         10        20        30        40        50        60g305.pep MDFLIVLKALMMGLVEGFTEFLPISSTGHLIVFGNLIGFHSNHKVFEIAIQLGAVLAVVF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m305MDFLIVLKALMMGLVEGFTEFLPISSIGHLIVFGNLIGFHSNHKVFEIAIQLGAVLAVVF        10        20        30        40        50        60        70        80        90       100       110       120 g305.pepEYRQRFSNVLHGVGKDRKANRFVLNLAIAFIPAAVMGLLFDKQIKEYLFNPLSVAVMLVL||||||||||||:|||||||||||||||||||||||||||  |||| ||||||||||||| m305EYRQRFSNVLHGLGKDRKANRFVLNLAIAFIPAAVMGLLFGXQIKEXLFNPLSVAVMLVL        70        80        90       100       110       120       130       140       150       160       170       180 g305.pepGGFFILWVEKRQSRAEPKIADVDALRPIDALMIGVAQVFALVPGTSRSGSTVMGGMLWGI || |||||||||||||||||||||||||||||||||||||||||||||||:|||||||| m305XGFXILWVEKRQSRAEPKIADVDALRPIDALMIGVAQVFALVPGTSRSGSTIMGGMLWGI       130       140       150       160       170       180       190       200       210       220       230       240 g305.pepERKTATEFSFFLAVPMMVAATAYDVLKHYRFFTLHDVGLILIGFIAAFVSGLVAVKALLK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: m305ERKTATEFSFFLAVPMMVAATAYDVLKHYRFFTLHDVGLILIGFIAAFVSGLVAVKALLR       190       200       210       220       230       240       250       260       270 g305.pepFVSKKNYIPFAYYRIVFGIVIIILWLSGWISWEX ||| m305 FVSGThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1263>:

a305.seq 1 ATGGATTTTC TGATTGTCCT GAAAGCCCTG ATGATGGGCT TGGTAGAAGG 51TTTTACCGAA TTTTTACCGA TTTCCAGCAC CGGACATTTG ATTGTGTTCG 101 GCAATCTGATTGATTTTCAC AGCAATCACA AGGTTTTTGA AATTACCATC 151 CAGCTCGGTG CGGTTTTGGCGGTAGTGTTT GAATACCGGC AGCGTTTCAG 201 CAATGTGTTG CATGGCGTGG GAAAAGACCGGAAAGCCAAC CGTTTCGTCC 251 TTAATCTTGC CATTGCTTTT ATACCTGCCG CCGTGATGGGGCTGTTGTTC 301 GGCAAACAAA TCAAAGAGTA TCTGTTTAAC CCCTTGAGTG TTGCAGTCAT351 GCTGGTTTTG GGCGGTTTTT TTATTTTGTG GGTGGAGAAA CGCCAAAGCC 401GAGCAGAGCC TAAAATTGTC GATGTTGATG CATTGCGTCC GATTGATGCG 451 TTGATGATCGGCGTTGCCCA AGTGTTTGCA CTGGTTCCAG GTACGTCCCG 501 TTCGGGCAGT ACGATTATGGGCGGGATGCT TTGGGGAATC GAGCGGAAAA 551 CGGCAACGGA GTTTTCATTT TTCTTGGCCGTTCCGATGAT GGTTGCAGCA 601 ACGGCTTATG ATGTCCTGAA GCATTACCGG TTTTTCACCCTGCATGATGT 651 CGGTTTGATT TTGATTGGCT TTGTTGCTGC CTTTGTTTCA GGCTTGGTGG701 CGGTCAAAGC GTTGCTGAGG TTTGTTTCCA AGAAAAATTA TATTCCTTTT 751GCCTATTACC GCATTGTTTT TGGTATTGCC ATCATTATAT TGTGGCTGTC 801 AGGCTGGATAAGTTGGGAAT GAThis corresponds to the amino acid sequence <SEQ ID 1264; ORF 305.a>:

a305.pep 1 MDFLIVLKAL MMGLVEGFTE FLPISSTGHL IVFGNLIDFH SNHKVFEITI 51QLGAVLAVVF EYRQRFSNVL HGVGKDRKAN RFVLNLAIAF IPAAVMGLLF 101 GKQIKEYLFNPLSVAVMLVL GGFFILWVEK RQSRAEPKIV DVDALRPIDA 151 LMIGVAQVFA LVPGTSRSGSTIMGGMLWGI ERKTATEFSF FLAVPMMVAA 201 TAYDVLKHYRFFTLHDVGLI LIGFVAAFVS GLVAVKALLR FVSKKNYIPF 251AYYRIVFGIA IIILWLSGWI SWE* m305/a305 96.3% identity in 243 aa overlap        10        20        30        40        50        60 m305.pepMDFLIVLKALMMGLVEGFTEFLPISSTGHLIVFGNLIGFHSNHKVFEIAIQLGAVLAVVF||||||||||||||||||||||||||||||||||||| ||||||||||:||||||||||| a305MDFLIVLKALMMGLVEGFTEFLPISSIGHLIVFGNLIDFHSNHKVFEITIQLGAVLAVVF        10        20        30        40        50        60        70        80        90       100       110       120 m305.pepEYRQRFSNVLHGLGKDRKANRFVLNLAIAFIPAAVMGLLFGXQIKEXLFNPLSVAVMLVL||||||||||||:|||||||||||||||||||||||||||| |||| ||||||||||||| a305EYRQRFSNVLHGVGKDRKANRFVLNLAIAFIPAAVMGLLFGKQIKEYLFNPLSVAVMLVL        70        80        90       100       110       120       130       140       150       160       170       180 m305.pepXGFXILWVEKRQSRAEPKIADVDALRPIDALMIGVAQVFALVPGTSRSGSTIMGGMLWGI || |||||||||||||||:|||||||||||||||||||||||||||||||||||||||| a305GGFFILWVEKRQSRAEPKIVDVDALRPIDALMIGVAQVFALVPGTSRSGSTIMGGMLWGI       130       140       150       160       170       180       190       200       210       220       230       240 m305.pepERKTATEFSFFLAVPMMVAATAYDVLKHYRFFTLHDVGLILIGFIAAFVSGLVAVKALLR||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||| a305ERKTATEFSFFLAVPMMVAATAYDVLKHYRFFTLHDVGLILIGFVAAFVSGLVAVKALLR       190       200       210       220       230       240 m305.pepFVSG ||| a305 FVSKKNYIPFAYYRIVFGIAIIILWLSGWISWEX       250       260       270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1265>:

g306.seq 1 ATGTTTATGA ACAAATTTTC CCAATCCGGA AAAGGTCTGT CCGGTTTCTT 51CTTCGGTTTG ATACTGGCAA CGGTCATTAT TGCCGGTATT TTGCTTTATC 101 TGAACCAGGGCGGTCAAAAT GCGTTCAAAA TCCCGGCTCC GTCGAAGCAG 151 CCTGCAGAAA CGGAAATCCTGAAACTGAAA AACCAGCCTA AGGAAGACAT 201 CCAACCTGAA CCGGCCGATC AAAACGCCTTGTCCGAACCG GATGTTGCGA 251 AAGAGGCAGA GCAGTCGGAT GCGGAAAAAG CTGCCGACAAGCAGCCCGTT 301 GCCGACAAAG CCGACGAGGT TGAAGAAAAG GCGGGCGAGC CGGAACGGGA351 AGAGCCGGAC GGACAGGCAG TGCGCAAGAA AGCACTGACT GAAGAGCGTG 401AACAAACCGT CAGGGAAAAA GCGCAGAAGA AAGATGCCGA AACGGTTAAA 451 AAAAAAGCGGTAAAACCGTC TAAAGAAACA GAGAAAAAAG CTTCAAAAGA 501 AGAGAAAAAG GCGGCGAAAGAAAAAGTTGC ACCCAAACCG ACCCCGGAAC 551 AAATCCTCAA CAGCCGCAGT ATCGAAAAAGCGCGTAGTGC CGCTGCCAAA 601 GAAGTGCAGA AAATGAAAAA CTTTGGGCAA GGCGGAAGCCAACGCATTAT 651 CTGCAAATGG GCGCGTATGC CGAACCCCGG AGCGCGGAAG GGCAGCGTGC701 CAAACTGGCA ATCTTGGGCA TATCTTCCGA AGTGGTCGGC TATCAGGCGG 751GACATAAAAC GCTTTACCGC GTGCAAAGCG GCAATATGTC CGCCGATGCG 801 GTGAThis corresponds to the amino acid sequence <SEQ ID 1266; ORF 306.ng>:

g306.pep 1 MFMNKFSQSG KGLSGFFFGL ILATVIIAGI LLYLNQGGQN AFKIPAPSKQ 51PAETEILKLK NQPKEDIQPE PADQNALSEP DVAKEAEQSD AEKAADKQPV 101 ADKADEVEEKAGEPEREEPD GQAVRKKALT EEREQTVREK AQKKDAETVK 151 KKAVKPSKET EKKASKEEKKAAKEKVAPKP TPEQILNSRS IEKARSAAAK 201 EVQKMKNFGQ GGSQRIICKW ARMPNPGARKGSVPNWQSWA YLPKWSAIRR 251 DIKRFTACKA AICPPMR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1267>:

m306.seq (partial) 1 ..GGTTTGTTCT TCGGTTTGAT ACTGGCGACG GTCATTATTGCCGGTATTTT 51   GTTTTATCTG AACCAGAGCG GTCAAAATGC GTTCAAAATC CCGGCTTCGT101   CGAAGCAGCC TGCAGAAACG GAAATCCTGA AACCGmAwAA CCAGCyTAAG 151  GAAGACATCC AACCTGAwCC GGCCGATCAA AACGCCTTGT CCGAACCGGA 201  TGCTGCGACA GAGGCAGAGC AGTCGGATGC GGAAAAwGCT GCCGACAAGC 251  AGCCCGTTGC CGATAAAGCC GACGAGGTTG AAGAAAAGGC GGGCGAGCCG 301  GAACGGGAAG AGCCGGACGG ACAGGCAGTG CGTAAGAAAG CGCTGACGGA 351  AGAGCGTGAA CAAACCGTCA GGGAAAAAGC GCAGAAGAAA GATGCCGAAA 401  CGGTTAAAAw ACAAGCGGTA AAACCGTCTA AAGAAACAGA GAAAAAAGCT 451  TCAAAAGAAG AGAAAAAGGC GGCGAAGGAA AAAGTTGCAC CCAAACCAAC 501  CCCGGAACAA ATCCTCAACA GCGGCAGCAT CGAAAAAGCG CGCAGTGCCG 551  CCGCCAAAGA AGTGCAGAAA ATGAAAACGC CGACAAGGCG GAAGCAACGC 601  ATTATCTGCA AATGGGCGCG TATGCCGACC GTCAGAGCGC GGAAGGGCAG 651  CGTGCCAAAC TGGCAATCTT GGGCATATCT TCCAAGGTGG TCGGTTATCA 701  GGCGGGACAT AAAACGCTTT ACCGGGTGCA AAGCGGCAAT ATGTCTGCCG 751   ATGCGGTGAThis corresponds to the amino acid sequence <SEQ ID 1268; ORF 306>:

m306.pep (partial) 1 ..GLFFGLILAT VIIAGILFYL NQSGQNAFKI PASSKQPAETEILKPXNQXK 51   EDIQPXPADQ NALSEPDAAT EAEQSDAEXA ADKQPVADKA DEVEEKAGEP101   EREEPDGQAV RKKALTEERE QTVREKAQKK DAETVKXQAV KPSKETEKKA 151  SKEEKKAAKE KVAPKPTPEQ ILNSGSIEKA RSAAAKEVQK MKTPTRRKQR 201  IICKWARMPT VRARKGSVPN WQSWAYLPRW SVIRRDIKRF TGCKAAICLP 251   MR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae ORF 306 shows 88.9%identity over a 253 aa overlap with a predicted ORF (ORF 306.ng) from N.gonorrhoeae:

m306/g306                       10        20        30        40m306.pep               GLFFGLILATVIIAGILFYLNQSGQNAFKIPASSKQPAETEILKPX              |:|||||||||||||||:||||:||||||||| ||||||||||| g306MFMNKFSQSGKGLSGFFFGLILATVIIAGILLYLNQGGQNAFKIPAPSKQPAETEILKLK        10        20        30        40        50        60  50        60        70        80        90       100 m306.pepNQXKEDIQPXPADQNALSEPDAATEAEQSDAEXAADKQPVADKADEVEEKAGEPEREEPD|| |||||| |||||||||||:| |||||||| ||||||||||||||||||||||||||| g306NQPKEDIQPEPADQNALSEPDVAKEAEQSDAEKAADKQPVADKADEVEEKAGEPEREEPD        70        80        90       100       110       120 110       120       130       140       150       160 m306.pepGQAVRKKALTEEREQTVREKAQKKDAETVKXQAVKPSKETEKKASKEEKKAAKEKVAPKP|||||||||||||||||||||||||||||| :|||||||||||||||||||||||||||| g306GQAVRKKALTEEREQTVREKAQKKDAETVKKKAVKPSKETEKKASKEEKKAAKEKVAPKP       130       140       150       160       170       180 170       180       190       200       210       220 m306.pepTPEQILNSGSIEKARSAAAKEVQKMKTPTRR-KQRIICKWARMPTVRARKGSVPNWQSWA|||||||| |||||||||||||||||:  :  :|||||||||||:  ||||||||||||| g306TPEQILNSRSIEKARSAAAKEVQKMKNFGQGGSQRIICKWARMPNPGARKGSVPNWQSWA       190       200       210       220       230       240  230       240       250 m306.pep YLPRWSVIRRDIKRFTGCKAAICLPMRX|||:||:|||||||||:|||||| |||| g306 YLPKWSAIRRDIKRFTACKAAICPPMRX       250       260The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1269>:

a306.seq 1 ATGTTTATGA ACAAATTTTC CCAATCCGGA AAAGGTCTGT CCGGTTTTTT 51CTTCGGTTTG ATACTGGCGA CGGTCATTAT TGCCGGTATT TTGTTTTATC 101 TGAACCAGAGCGGTCAAAAT GCGTTCAAAA TCCCGGTTCC GTCGAAGCAG 151 CCTGCAGAAA CGGAAATCCTGAAACCGAAA AACCAGCCTA AGGAAGACAT 201 CCAACCTGAA CCGGCCGATC AAAACGCCTTGTCCGAACCG GATGCTGCGA 251 AAGAGGCAGA GCAGTCGGAT GCGGAAAAAG CTGCCGACAAGCAGCCCGTT 301 GCCGACAAAG CCGACGAGGT TGAGGAAAAG GCGGACGAGC CGGAGCGGGA351 AAAGTCGGAC GGACAGGCAG TGCGCAAGAA AGCACTGACG GAAGAGCGTG 401AACAAACCGT CGGGGAAAAA GCGCAGAAGA AAGATGCCGA AACGGTTAAA 451 AAACAAGCGGTAAAACCATC TAAAGAAACA GAGAAAAAAG CTTCAAAAGA 501 AGAGAAAAAG GCGGAGAAGGAAAAAGTTGC ACCCAAACCG ACCCCGGAAC 551 AAATCCTCAA CAGCGGCAGC ATCGAAAAAGCGCGCAGTGC CGCTGCCAAA 601 GAAGTGCAGA AAATGAAAAC GCCGACAAGG CGGAAGCAACGCATTATCTG 651 CAAATGGGCG CGTATGCCGA CCGCCGGAGC GCGGAAGGGC AGCGTGCCAA701 ACTGGCAATC TTGGGCATAT CTTCCAAGGT GGTCGGTTAT CAGGCGGGAC 751ATAAAACGCT TTACCGGGTG CAAAGCGGCA ATATGTCTGC CGATGCGGTG 801 AThis corresponds to the amino acid sequence <SEQ ID 1270; ORF 306.a>:

a306.pep 1 MFMNKFSQSG KGLSGFFFGL ILATVIIAGI LFYLNQSGQN AFKIPVPSKQ 51PAETEILKPK NQPKEDIQPE PADQNALSEP DAAKEAEQSD AEKAADKQPV 101 ADKADEVEEKADEPEREKSD GQAVRKKALT EEREQTVGEK AQKKDAETVK 151 KQAVKPSKET EKKASKEEKKAEKEKVAPKP TPEQILNSGS IEKARSAAAK 201 EVQKMKTPTR RKQRIICKWA RMPTAGARKGSVPNWQSWAY LPRWSVIRRD 251 IKRFTGCKAA ICLPMR* m306/a306 93.7% identity in252 aa overlap                       10        20        30        40m306.pep               GLFFGLILATVIIAGILFYLNQSGQNAFKIPASSKQPAETEILKPX              |:|||||||||||||||||||||||||||||: |||||||||||| a306MFMNKFSQSGKGLSGFFFGLILATVIIAGILFYLNQSGQNAFKIPVPSKQPAETEILKPK        10        20        30        40        50        60  50        60        70        80        90       100 m306.pepNQXKEDIQPXPADQNALSEPDAATEAEQSDAEXAADKQPVADKADEVEEKAGEPEREEPD|| |||||| ||||||||||||| |||||||| |||||||||||||||||| |||||: | a306NQPKEDIQPEPADQNALSEPDAAKEAEQSDAEKAADKQPVADKADEVEEKADEPEREKSD        70        80        90       100       110       120 110       120       130       140       150       160 m306.pepGQAVRKKALTEEREQTVREKAQKKDAETVKXQAVKPSKETEKKASKEEKKAAKEKVAPKP||||||||||||||||| |||||||||||| |||||||||||||||||||| |||||||| a306GQAVRKKALTEEREQTVGEKAQKKDAETVKKQAVKPSKETEKKASKEEKKAEKEKVAPKP       130       140       150       160       170       180 170       180       190       200       210       220 m306.pepTPEQILNSGSIEKARSAAAKEVQKMKTPTRRKQRIICKWARMPTVRARKGSVPNWQSWAY||||||||||||||||||||||||||||||||||||||||||||: |||||||||||||| a306TPEQILNSGSIEKARSAAAKEVQKMKTPTRRKQRIICKWARMPTAGARKGSVPNWQSWAY       190       200       210       220       230       240 230       240       250 m306.pep LPRWSVIRRDIKRFTGCKAAICLPMRX||||||||||||||||||||||||||| a306 LPRWSVIRRDIKRFTGCKAAICLPMRX       250       260The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1271>:

g307.seq 1 atgaaaacct tcttcaaaac cctttcgacc gcgtcactcg cgctcatcct 51cgcagcctgc ggcggtcaaa aagacagcgc gcccgcagcc tctgccgccg 101 ccccttctgccgataacggc gcggcgaaaa aagaaatcgt cttcggcacg 151 accgtgggcg acttcggcgatatggtcaaa gaacaaatcc aagccgagct 201 ggagaaaaaa ggctacaccg tcaaattggtcgaatttacc gactatgtgc 251 gcccgaatct ggcattggcg gagggcgagt tggacatcaacgtcttccaa 301 cacaaaccct atcttgacga tttcaaaaaa gaacacaacc tggacatcac351 cgaagccttc caagtgccga ccgcgccttt gggactgtat ccgggcaaac 401tgaaatcgct ggaagaagtc aaagacggca gcaccgtatc cgcgcccaac 451 gacccgtccaacttcgcacg cgccttggtg atgctgaacg aactgggttg 501 gatcaaactc aaagacggcatcaatccgct gaccgcatcc aaagccgaca 551 tcgcggaaaa cctgaaaaac atcaaaatcgtcgagcttga agccgcacaa 601 ctgccgcgca gccgcgccga cgtggatttt gccgtcgtcaacggcaacta 651 cgccataagc agcggcatga agctgaccga agccctgttc caagagccga701 gctttgccta tgtcaactgg tctgccgtca aaaccgccga caaagacagc 751caatggctta aagacgtaac cgaggcctat aactccgacg cgttcaaagc 801 ctacgcgcacaaacgcttcg agggctacaa ataccctgcc gcatggaatg 851 aaggcgcagc caaataaThis corresponds to the amino acid sequence <SEQ ID 1272; ORF 307.ng>:

g307.pep 1 MKTFFKTLST ASLALILAAC GGQKDSAPAA SAAAPSADNG AAKKEIVFGT 51TVGDFGDMVK EQIQAELEKK GYTVKLVEFT DYVRPNLALA EGELDINVFQ 101 HKPYLDDFKKEHNLDITEAF QVPTAPLGLY PGKLKSLEEV KDGSTVSAPN 151 DPSNFARALV MLNELGWIKLKDGINPLTAS KADIAENLKN IKIVELEAAQ 201 LPRSRADVDF AVVNGNYAIS SGMKLTEALFQEPSFAYVNW SAVKTADKDS 251 QWLKDVTEAY NSDAFKAYAH KRFEGYKYPA AWNEGAAK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1273>:

m307.seq (partial) 1 ..CAATGGCTTA AAGACGTAAC CGAGGCCTAT AACTCCGACGCGTTCAAAGC 51   CTACGCGCAC AAACGCTTCG AGGGCTACAA ATCCCCTGCC GCATGGAATG101   AAGGCGCAGC CAAATAAThis corresponds to the amino acid sequence <SEQ ID 1274; ORF 307>:

m307.pep (partial) 1 ..QWLKDVTEAY NSDAFKAYAH KRFEGYKSPA AWNEGAAK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae ORF 307 shows 97.4%identity over a 38 aa overlap with a predicted ORF (ORF 307.ng) from N.gonorrhoeae:

m307/g307                                       10        20        30m307.pep                               QWLKDVTEAYNSDAFKAYAHKRFEGYKSPA                              ||||||||||||||||||||||||||| || g307SGMKLTEALFQEPSFAYVNWSAVKTADKDSQWLKDVTEAYNSDAFKAYAHKRFEGYKYPA       230       240       250       260       270       280        39m307.pep AWNEGAAKX ||||||||| g307 AWNEGAAKXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1275>:

a307.seq 1 ATGAAAACCT TCTTCAAAAC CCTTTCCGCC GCCGCACTCG CGCTCATCCT 51CGCCGCCTGC GGCGGTCAAA AAGATAGCGC GCCCGCCGCA TCCGCTTCTG 101 CCGCCGCCGACAACGGCGCG GCGAAAAAAG NAATCGTCTT CGGCACGACC 151 GTCGGCGACT TCGGCGATATGGTCAAAGAA CAAATCCAAC CCGAGCTGGA 201 GAAAAAAGGC TACACCGTCA AACTGGTCGAGTTTACCGAC TATGTGCGCC 251 CGAATCTGGC ATTGGCTGAG GGCGAGTNGG ACATCAACGTCTTCCAACAC 301 AAACCCTATC TTGACGACTT CAAAAAAGAA CACAATCTGG ACATCACCGA351 AGTCTTCCAA GTGCCGACCG CGCCTTTGGG ACTGTACCCG GGCAAGCTGA 401AATCGCTGGA AGAAGTCAAA GACGGCAGCA CCGTATCCGC GCCCAACGAC 451 CCGTCCAACTTCGCCCGCGT CTTGGTGATG CTCGACGAAC TGGGTTGGAT 501 CAAACTCAAA GANGGCATCAATCCGCTGAC CGCATCCAAA GCGGACATTG 551 CCGAAAACCT GAAAAACATC AAAATCGTCGAGCTTGAAGC CGCGCAACTG 601 CCGCGTAGCC GCGCCGACGT GGATTTTGNC GTCGTCAACGGCAANTACGC 651 CATAAGCAGC GGCATGAAGC TGACCGAAGC CCTGTTCCAA GAACCGAGCT701 TTGCCTATGT CAACTGGTCT GCCGTCAAAA CCGCCGACAA AGACAGCCAA 751TGGCTTAAAG ACGTAACCGA GGCCTATAAC TCCGACGCGT TCAAAGCCTA 801 CGCGCACAAACGCTTCGAGG GCTACAAATC CCCTGCCGCA TGGAATGAAG 851 GCGCAGCCAA ATAAThis corresponds to the amino acid sequence <SEQ ID 1276; ORF 307.a>:

a307.pep 1 MKTFFKTLSA AALALILAAC GGQKDSAPAA SASAAADNGA AKKXIVFGTT 51VGDFGDMVKE QIQPELEKKG YTVKLVEFTD YVRPNLALAE GEXDINVFQH 101 KPYLDDFKKEHNLDITEVFQ VPTAPLGLYP GKLKSLEEVK DGSTVSAPND 151 PSNFARVLVM LDELGWIKLKXGINPLTASK ADIAENLKNI KIVELEAAQL 201 PRSRADVDFX VVNGXYAISS GMKLTEALFQEPSFAYVNWS AVKTADKDSQ 251 WLKDVTEAYN SDAFKAYAHK RFEGYKSPAA WNEGAAK*m307/a307 100.0% identity in 38 aa overlap                                        10        20        30 m307.pep                                QWLKDVTEAYNSDAFKAYAHKRFEGYKSPA                                |||||||||||||||||||||||||||||| a307  SGMKLTEALFQEPSFAYVNWSAVKTADKDSQWLKDVTEAYNSDAFKAYAHKRFEGYKSPA220       230       240       250       260       270          39m307.pep   AWNEGAAKX   ||||||||| a307   AWNEGAAKX 280The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1277>:

g308.seq 1 ATGTTAAATC GGGTATTTTA TCGGATATTG GGTGTTGCCG ACAATTTGTA 51TCCGTGTTTA TCGGATTTCT GTTTTTTCAC TATAATAGCC GGTTTGCCGT 101 TGCAGGCGGTTTTATGGGAA AGGCGGATGA TGGTACGGCG TTTGATAATC 151 GGCATCAGCG GGGCGAGCGGTTTCCAATAC GGCGTGAAGG CTTTGGAACT 201 TTTGCGCGCG CAAGATGTCG AAACGCACCTTGTGGTATCG AAAGGCGCGG 251 AGATGGCGCG CGCTTCGGAA ACGGATTATA CGAAAGACGAAGTATATGCC 301 TTGGCTGATT TCGTCCATCC GATCGGCAAT ATCGGGGCGT GCATTGCCAG351 CGGTACGTTT AAAACGGACG GGATGCTGGT CGCACCCTGT TCGATGCGGA 401CGCTTGCCTC TGTCGCGCAC GGCTTCGGCG ACAACCTCTT GACGCGTGCG 451 GCGGATGTGGTTTTGAAGGA AAGGCGGCGG CTGGTGCTGA TGGTGCGCGA 501 AACGCCGCTG AACCTTGCCCATTTGGACAA TATGAAGCGG GTAACGGAAA 551 TGGGCGGCGT GGTGTTTCCC CCTGTTCCTGCGATGTACCG CAAGCCGCAG 601 ACGGCGGACG ACATAGTGGC GCACAGTATC GCACACACGCTGTCGCTGTT 651 CGGAATCGAT ACGCCGGATT TGGCGGAATG GCAGGGAATG GCGGATTAAThis corresponds to the amino acid sequence <SEQ ID 1278; ORF 308.ng>:

g308.pep 1 MLNRVFYRIL GVADNLYPCL SDFCFFTIIA GLPLQAVLWE RRMMVRRLII 51GISGASGFQY GVKALELLRA QDVETHLVVS KGAEMARASE TDYTKDEVYA 101 LADFVHPIGNIGACIASGTF KTDGMLVAPC SMRTLASVAH GFGDNLLTRA 151 ADVVLKERRR LVLMVRETPLNLAHLDNMKR VTEMGGVVFP PVPAMYRKPQ 201 TADDIVAHSI AHTLSLFGID TPDLAEWQGMAD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1279>:

m308.seq (partial) 1 ATGTTAAATC GGGTATTTTA TCGGATATTG GGTGTTGCCGACAATTTGTA 51 TCCGCGTTTA TCGGATTTCT GTTTTTTCAC TATAATAGCC GGTTTGCCGT 101TGCAGGCGGT TTTATGGGAA AGGCGGATGA TGGTACGGCG TTTGATAATC 151 GGCATCAGCGGGGCGAGCGG TTTCCAATAC GGCGTGAAGG CTTTGGAACT 201 TTTGCGCGCG CAAGATGTCGAAACGCACCT TGTGGTATCG AAAGGTGCGG 251 AGATGGCGCG CGCTTCGGAA ACGGCTTATGCGAGAGACGA GGTATATGCC 301 TTGGCGGACT TCGTGCATCC GATCGGCAAT ATCGGGGCGTGCATTGCCAG 351 CGGTACGTTT AAAACGGATG GGATGCTGGT CGCCCCCTGT TCGATGCGGA401 CGCTTGCCTC TGTCGCGCAC GGCTTCGGCG ACAATCTGcT GACGCgTGCG 451GCGGATGTGG TTTTGAAGGA AAGGCGGCGG CTGGTGCTGA TGGTGCGCGA 501 AACGCCGCTGAACCTTGCCC ATTTGGACAA TATGAAGCGG GwAACGGAAA 551 TGGGCGGCGT GGTGTTTCCCCCTGTTCCTG CGATGTACCG CAAACCGCAG 601 ACGGCGGACG ACATAGTGGC GCACAGTGTTGCACACGCtT TGTCGCTGTT 651 CGGAATCGAT ACGCCGGATT CGGCGGAATG GCArGGAATGgcG...This corresponds to the amino acid sequence <SEQ ID 1280; ORF 308>:

m308.pep (partial) 1 MLNRVFYRIL GVADNLYPRL SDFCFFTIIA GLPLQAVLWERRMMVRRLII 51 GISGASGFQY GVKALELLRA QDVETHLVVS KGAEMARASE TAYARDEVYA 101LADFVHPIGN IGACIASGTF KTDGMLVAPC SMRTLASVAH GFGDNLLTRA 151 ADVVLKERRRLVLMVRETPL NLAHLDNMKR XTEMGGVVFP PVPAMYRKPQ 201 TADDIVAHSV AHALSLFGIDTPDSAEWQGM A..Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae ORF 308 shows 96.5%identity over a 231 aa overlap with a predicted ORF (ORF 308.ng) from N.gonorrhoeae:

m308/g308         10        20        30        40        50        60m308.pep MLNRVFYRILGVADNLYPRLSDFCFFTIIAGLPLQAVLWERRMMVRRLIIGISGASGFQY|||||||||||||||||| ||||||||||||||||||||||||||||||||||||||||| g308MLNRVFYRILGVADNLYPCLSDFCFFTIIAGLPLQAVLWERRMMVRRLIIGISGASGFQY        10        20        30        40        50        60        70        80        90       100       110       120 m308.pepGVKALELLRAQDVETHLVVSKGAEMARASETAYARDEVYALADFVHPIGNIGACIASGTF||||||||||||||||||||||||||||||| |::||||||||||||||||||||||||| g308GVKALELLRAQDVETHLVVSKGAEMARASETDYTKDEVYALADFVHPIGNIGACIASGTF        70        80        90       100       110       120       130       140       150       160       170       180 m308.pepKTDGMLVAPCSMRTLASVAHGFGDNLLTRAADVVLKERRRLVLMVRETPLNLAHLDNMKR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g308KTDGMLVAPCSMRTLASVAHGFGDNLLTRAADVVLKERRRLVLMVRETPLNLAHLDNMKR       130       140       150       160       170       180       190       200       210       220       230 m308.pepXTEMGGVVFPPVPAMYRKPQTADDIVAHSVAHALSLFGIDTPDSAEWQGMA ||||||||||||||||||||||||||||:||:|||||||||| ||||||| g308VTEMGGVVFPPVPAMYRKPQTADDIVAHSIAHTLSLFGIDTPDLAEWQGMADX       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1281>:

a308.seq 1 ATGTTAAATC GGATATTTTA TCGGATATTG GGTGTTGCCG ACAATTTGTA 51TCCGTATTTA TCGGATTTCT GTTTTTTCAC TATAATAGCC GGTTTGCCGT 101 TGCAGGCGGTTTTATGGGAA AGGCGGATGA TGGTACGGCG TTTGATAATC 151 GGCATCAGTG GGGCGAGCGGTTTCCAATAC GGCGTGAAGG CTTTGGANCT 201 TTTACGCGCG CAAGATATCG AAACGCACCTTGTGGTATCG AAAGGTGCGG 251 AGATGGCGCG CGCTTCGGAA ACGGNTTATG CGAGAGACGANGTATATGCC 301 TTGGCGGACT TNGTGCATCC GATCGGCAAT ATCGGGGCGT GCATTGCCAG351 CGGTACGTTT AAAACGGACG GGATGCTGGT CGCCCCCTGT TCGATGCGGA 401CGCTTGCCTC GGTCGTGCAC GGCTTCGGCG ACAACCTCTT GACGCGTGCG 451 GCGGATGTGGTTTTGAAGGA AAGGCGGCGG CTGGTGCTGA TGGTGCGCGA 501 AACGCCGCTG AACCTTGCCCATTTGGACAA TATGAANCGG GTAACGGAAA 551 TGGGCGGCGT GGTGTTTCCC CCTGTTCCTGCGATGTACCG CAAACCGCAG 601 ACGGCGGACG ACATAGTGGC GCACAGTGTT GCACACGCTTTGTCGCTGTT 651 CGGAATCGAT ACGCCGGATT CGGCGGAATG GCAGGGAATG GCGGATTAAThis corresponds to the amino acid sequence <SEQ ID 1282; ORF 308.a>:

a308.pep 1 MLNRIFYRIL GVADNLYPYL SDFCFFTIIA GLPLQAVLWE RRMMVRRLII 51GISGASGFQY GVKALXLLRA QDIETHLVVS KGAEMARASE TXYARDXVYA 101 LADXVHPIGNIGACIASGTF KTDGMLVAPC SMRTLASVVH GFGDNLLTRA 151 ADVVLKERRR LVLMVRETPLNLAHLDNMXR VTEMGGVVFP PVPAMYRKPQ 201 TADDIVAHSV AHALSLFGID TPDSAEWQGMAD* m308/a308 95.7% identity in 231 aa overlap        10        20        30        40        50        60 m308.pepMLNRVFYRILGVADNLYPRLSDFCFFTIIAGLPLQAVLWERRMMVRRLIIGISGASGFQY||||:||||||||||||| ||||||||||||||||||||||||||||||||||||||||| a308MLNRIFYRILGVADNLYPYLSDFCFFTIIAGLPLQAVLWERRMMVRRLIIGISGASGFQY        10        20        30        40        50        60        70        80        90       100       110       120 m308.pepGVKALELLRAQDVETHLVVSKGAEMARASETAYARDEVYALADFVHPIGNIGACIASGTF||||| ||||||:|||||||||||||||||| |||| |||||| |||||||||||||||| a308GVKALXLLRAQDIETHLVVSKGAEMARASETXYARDXVYALADXVHPIGNIGACIASGTF        70        80        90       100       110       120       130       140       150       160       170       180 m308.pepKTDGMLVAPCSMRTLASVAHGFGDNLLTRAADVVLKERRRLVLMVRETPLNLAHLDNMKR||||||||||||||||||:||||||||||||||||||||||||||||||||||||||| | a308KTDGMLVAPCSMRTLASVVHGFGDNLLTRAADVVLKERRRLVLMVRETPLNLAHLDNMXR       130       140       150       160       170       180       190       200       210       220       230 m308.pepXTEMGGVVFPPVPAMYRKPQTADDIVAHSVAHALSLFGIDTPDSAEWQGMA |||||||||||||||||||||||||||||||||||||||||||||||||| a308VTEMGGVVFPPVPAMYRKPQTADDIVAHSVAHALSLFGIDTPDSAEWQGMADX       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1283>:

g308-1.seq 1 ATGTTAAATC GGGTATTTTA TCGGATATTG GGTGTTGCCG ACAATTTGTA 51TCCGTGTTTA TCGGATTTCT GTTTTTTCAC TATAATAGCC GGTTTGCCGT 101 TGCAGGCGGTTTTATGGGAA AGGCGGATGA TGGTACGGCG TTTGATAATC 151 GGCATCAGCG GGGCGAGCGGTTTCCAATAC GGCGTGAAGG CTTTGGAACT 201 TTTGCGCGCG CAAGATGTCG AAACGCACCTTGTGGTATCG AAAGGCGCGG 251 AGATGGCGCG CGCTTCGGAA ACGGATTATA CGAAAGACGAAGTATATGCC 301 TTGGCTGATT TCGTCCATCC GATCGGCAAT ATCGGGGCGT GCATTGCCAG351 CGGTACGTTT AAAACGGACG GGATGCTGGT CGCACCCTGT TCGATGCGGA 401CGCTTGCCTC TGTCGCGCAC GGCTTCGGCG ACAACCTCTT GACGCGTGCG 451 GCGGATGTGGTTTTGAAGGA AAGGCGGCGG CTGGTGCTGA TGGTGCGCGA 501 AACGCCGCTG AACCTTGCCCATTTGGACAA TATGAAGCGG GTAACGGAAA 551 TGGGCGGCGT GGTGTTTCCC CCTGTTCCTGCGATGTACCG CAAGCCGCAG 601 ACGGCGGACG ACATAGTGGC GCACAGTATC GCACACACGCTGTCGCTGTT 651 CGGAATCGAT ACGCCGGATT TGGCGGAATG GCAGGGAATG GCGGATTAAThis corresponds to the amino acid sequence <SEQ ID 1284; ORF 308-1.ng>:

g308-1.pep 1 MLNRVFYRIL GVADNLYPCL SDFCFFTIIA GLPLQAVLWE RRMMVRRLII 51GISGASGFQY GVKALELLRA QDVETHLVVS KGAEMARASE TDYTKDEVYA 101 LADFVHPIGNIGACIASGTF KTDGMLVAPC SMRTLASVAH GFGDNLLTRA 151 ADVVLKERRR LVLMVRETPLNLAHLDNMKR VTEMGGVVFP PVPAMYRKPQ 201 TADDIVAHSI AHTLSLFGID TPDLAEWQGMAD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1285>:

m308-1.seq 1 ATGTTAAATC GGGTATTTTA TCGGATATTG GGTGTTGCCG ACAATTTGTA 51TCCGCGTTTA TCGGATTTCT GTTTTTTCAC TATAATAGCC GGTTTGCCGT 101 TGCAGGCGGTTTTATGGGAA AGGCGGATGA TGGTACGGCG TTTGATAATC 151 GGCATCAGCG GGGCGAGCGGTTTCCAATAC GGCGTGAAGG CTTTGGAACT 201 TTTGCGCGCG CAAGATGTCG AAACGCACCTTGTGGTATCG AAAGGTGCGG 251 AGATGGCGCG CGCTTCGGAA ACGGCTTATG CGAGAGACGAGGTATATGCC 301 TTGGCGGACT TCGTGCATCC GATCGGCAAT ATCGGGGCGT GCATTGCCAG351 CGGTACGTTT AAAACGGATG GGATGCTGGT CGCCCCCTGT TCGATGCGGA 401CGCTTGCCTC TGTCGCGCAC GGCTTCGGCG ACAATCTGCT GACGCGTGCG 451 GCGGATGTGGTTTTGAAGGA AAGGCGGCGG CTGGTGCTGA TGGTGCGCGA 501 AACGCCGCTG AACCTTGCCCATTTGGACAA TATGAAGCGG GTAACGGAAA 551 TGGGCGGCGT GGTGTTTCCC CCTGTTCCTGCGATGTACCG CAAACCGCAG 601 ACGGCGGACG ACATAGTGGC GCACAGTGTT GCACACGCTTTGTCGCTGTT 651 CGGAATCGAT ACGCCGGATT CGGCGGAATG GCAGGGAATG GCGGATTAAThis corresponds to the amino acid sequence <SEQ ID 1286; ORF 308-1>:

m308-1.pep 1 MLNRVFYRIL GVADNLYPRL SDFCFFTIIA GLPLQAVLWE RRMMVRRLII 51GISGASGFQY GVKALELLRA QDVETHLVVS KGAEMARASE TAYARDEVYA 101 LADFVHPIGNIGACIASGTF KTDGMLVAPC SMRTLASVAH GFGDNLLTRA 151 ADVVLKERRR LVLMVRETPLNLAHLDNMKR VTEMGGVVFP PVPAMYRKPQ 201 TADDIVAHSV AHALSLFGID TPDSAEWQGMAD* m308-1/g308-1 97.0% identity in 232 aa overlap        10        20        30        40        50        60 m308-1.pepMLNRVFYRILGVADNLYPRLSDFCFFTIIAGLPLQAVLWERRMMVRRLIIGISGASGFQY|||||||||||||||||| ||||||||||||||||||||||||||||||||||||||||| g308-1MLNRVFYRILGVADNLYPCLSDFCFFTIIAGLPLQAVLWERRMMVRRLIIGISGASGFQY        10        20        30        40        50        60        70        80        90       100       110       120 m308-1.pepGVKALELLRAQDVETHLVVSKGAEMARASETAYARDEVYALADFVHPIGNIGACIASGTF||||||||||||||||||||||||||||||| |::||||||||||||||||||||||||| g308-1GVKALELLRAQDVETHLVVSKGAEMARASETDYTKDEVYALADFVHPIGNIGACIASGTF        70        80        90       100       110       120       130       140       150       160       170       180 m308-1.pepKTDGMLVAPCSMRTLASVAHGFGDNLLTRAADVVLKERRRLVLMVRETPLNLAHLDNMKR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g308-1KTDGMLVAPCSMRTLASVAHGFGDNLLTRAADVVLKERRRLVLMVRETPLNLAHLDNMKR       130       140       150       160       170       180       190       200       210       220       230 m308-1.pepVTEMGGVVFPPVPAMYRKPQTADDIVAHSVAHALSLFGIDTPDSAEWQGMADX|||||||||||||||||||||||||||||:||:|||||||||| ||||||||| g308-1VTEMGGVVFPPVPAMYRKPQTADDIVAHSIAHTLSLFGIDTPDLAEWQGMADX       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1287>:

a308-1.seq 1 ATGTTAAATC GGATATTTTA TCGGATATTG GGTGTTGCCG ACAATTTGTA 51TCCGTATTTA TCGGATTTCT GTTTTTTCAC TATAATAGCC GGTTTGCCGT 101 TGCAGGCGGTTTTATGGGAA AGGCGGATGA TGGTACGGCG TTTGATAATC 151 GGCATCAGTG GGGCGAGCGGTTTCCAATAC GGCGTGAAGG CTTTGGANCT 201 TTTACGCGCG CAAGATATCG AAACGCACCTTGTGGTATCG AAAGGTGCGG 251 AGATGGCGCG CGCTTCGGAA ACGGNTTATG CGAGAGACGANGTATATGCC 301 TTGGCGGACT TNGTGCATCC GATCGGCAAT ATCGGGGCGT GCATTGCCAG351 CGGTACGTTT AAAACGGACG GGATGCTGGT CGCCCCCTGT TCGATGCGGA 401CGCTTGCCTC GGTCGTGCAC GGCTTCGGCG ACAACCTCTT GACGCGTGCG 451 GCGGATGTGGTTTTGAAGGA AAGGCGGCGG CTGGTGCTGA TGGTGCGCGA 501 AACGCCGCTG AACCTTGCCCATTTGGACAA TATGAANCGG GTAACGGAAA 551 TGGGCGGCGT GGTGTTTCCC CCTGTTCCTGCGATGTACCG CAAACCGCAG 601 ACGGCGGACG ACATAGTGGC GCACAGTGTT GCACACGCTTTGTCGCTGTT 651 CGGAATCGAT ACGCCGGATT CGGCGGAATG GCAGGGAATG GCGGATTAAThis corresponds to the amino acid sequence <SEQ ID 1288; ORF 308-1.a>:

a308-1.pep 1 MLNRIFYRIL GVADNLYPYL SDFCFFTIIA GLPLQAVLWE RRMMVRRLII 51GISGASGFQY GVKALXLLRA QDIETHLVVS KGAEMARASE TXYARDXVYA 101 LADXVHPIGNIGACIASGTF KTDGMLVAPC SMRTLASVVH GFGDNLLTRA 151 ADVVLKERRR LVLMVRETPLNLAHLDNMXR VTEMGGVVFP PVPAMYRKPQ 201 TADDIVAHSV AHALSLFGID TPDSAEWQGMAD* a308-1/m308-1 96.1% identity in 232 aa overlap        10        20        30        40        50        60 a308-1MLNRIFYRILGVADNLYPYLSDFCFFTIIAGLPLQAVLWERRMMVRRLIIGISGASGFQY||||:||||||||||||| ||||||||||||||||||||||||||||||||||||||||| m308-1MLNRVFYRILGVADNLYPRLSDFCFFTIIAGLPLQAVLWERRMMVRRLIIGISGASGFQY        10        20        30        40        50        60        70        80        90       100       110       120 a308-1GVKALXLLRAQDIETHLVVSKGAEMARASETXYARDXVYALADXVHPIGNIGACIASGTF||||| ||||||:|||||||||||||||||| |||| |||||| |||||||||||||||| m308-1GVKALELLRAQDVETHLVVSKGAEMARASETAYARDEVYALADFVHPIGNIGACIASGTF        70        80        90       100       110       120       130       140       150       160       170       180 a308-1KTDGMLVAPCSMRTLASVVHGFGDNLLTRAADVVLKERRRLVLMVRETPLNLAHLDNMXR||||||||||||||||||:||||||||||||||||||||||||||||||||||||||| | m308-1KTDGMLVAPCSMRTLASVAHGFGDNLLTRAADVVLKERRRLVLMVRETPLNLAHLDNMKR       130       140       150       160       170       180       190       200       210       220       230 a308-1VTEMGGVVFPPVPAMYRKPQTADDIVAHSVAHALSLFGIDTPDSAEWQGMADX||||||||||||||||||||||||||||||||||||||||||||||||||||| m308-1VTEMGGVVFPPVPAMYRKPQTADDIVAHSVAHALSLFGIDTPDSAEWQGMADX       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1289>:

g311.seq 1 atgttcagtt tcggctgggc gtttgaccgc ccgcagtatg agttgggttc 51gctgtcgcct gttgcggcac ttgcgtgccg gcgcgctttg gggtgtttgg 101 gtttggaaacgcaaatcaag tggccaaacg atttggtcgt cggacgcgac 151 aaattgggcg gcattctgattgaaacagtc agggcgggcg gtaaaacggt 201 tgccgtggtc ggtatcggca tcaatttcgtgctgcccaag gaagtggaaa 251 acgccgcttc cgtgcagtcg ctgtttcaga cggcatcgcggcggggcaat 301 gccgatgccg ccgtattgct ggaaacattg cttgcggaac tgggcgcggt351 gttggaacaa tatgcggaag aagggttcgc gccattttta aatgagtatg 401aaacggccaa ccgcgaccac ggcaaggcgg tattgctgtt gcgcgacggc 451 gaaaccgtgtgcgaaggcac ggttaaaggc gtggacggac gaggcgttct 501 gcacttggaa acggcagaaggcgaacagac ggtcgtcagc ggcgaaatca 551 gcctgcggcc cgacaacagg tcggtttccgtgccgaagcg gccggattcg 601 gaacgttttt tgctgttgga aggcgggaac agccggctcaagtgggcgtg 651 ggtggaaaac ggcacgttcg caaccgtggg cagcgcgccg taccgcgatt701 tgtcgccttt gggcgcggag tgggcggaaa aggcggatgg aaatgtccgc 751atcgtcggtt gcgccgtgtg cggagaatcc aaaaaggcac aagtgaagga 801 acagctcgcccgaaaaatcg agtggctgcc gtcttccgca caggctttgg 851 gcatacgcaa ccactaccgccaccccgaag aacacggttc cgaccgttgg 901 ttcaacgcct tgggcagccg ccgcttcagccgcaacgcct gcgtcgtcgt 951 cagttgcggc acggcggtaa cggttgacgc gctcaccgatgacggacatt 1001 atctcggcgg aaccatcatg cccggcttcc acctgatgaa agaatcgctc1051 gccgtccgaa ccgccaacct caaccgcccc gccggcaaac gttacccttt 1101cccgaccaca acgggcaacg ccgtcgcaag cggcatgatg gacgcggttt 1151 gcggctcgataatgatgatg cacggccgtt tgaaagaaaa aaacggcgcg 1201 ggcaagcctg tcgatgtcatcattaccggc ggcggcgcgg cgaaagtcgc 1251 cgaagccctg ccgcctgcat ttttggcggaaaataccgtg cgcgtggcgg 1301 acaacctcgt catccacggg ctgctgaacc tgattgccgccgaaggcggg 1351 gaatcggaac acgcttaaThis corresponds to the amino acid sequence <SEQ ID 1290; ORF 311.ng>:

g311.pep 1 MFSFGWAFDR PQYELGSLSP VAALACRRAL GCLGLETQIK WPNDLVVGRD 51KLGGILIETV RAGGKTVAVV GIGINFVLPK EVENAASVQS LFQTASRRGN 101 ADAAVLLETLLAELGAVLEQ YAEEGFAPFL NEYETANRDH GKAVLLLRDG 151 ETVCEGTVKG VDGRGVLHLETAEGEQTVVS GEISLRPDNR SVSVPKRPDS 201 ERFLLLEGGN SRLKWAWVEN GTFATVGSAPYRDLSPLGAE WAEKADGNVR 251 IVGCAVCGES KKAQVKEQLA RKIEWLPSSA QALGIRNHYRHPEEHGSDRW 301 FNALGSRRFS RNACVVVSCG TAVTVDALTD DGHYLGGTIM PGFHLMKESL351 AVRTANLNRP AGKRYPFPTT TGNAVASGMM DAVCGSIMMM HGRLKEKNGA 401GKPVDVIITG GGAAKVAEAL PPAFLAENTV RVADNLVIHG LLNLIAAEGG 451 ESEHA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1291>:

m311.seq (partial) 1 ATGTTCAGTT TTGGCTGGGT GTTTGACCGG CCGCAGTATGAGTTGGGTTC 51 GCTGTCGCCT GTTGCGGCAG TGGCGTGTCG GCGCGCCTTG TCGCGTTTAG 101GTTTGGATGT GCArATTAAG TGGCCCAATG ATTTGGTTGT CGGACGCGAC 151 AAATTGGGCGGCATTCTGAT TGAAACGGTC AGGACGGGCG GCAAAACGGT 201 TGCCGTGGTC GGTATCGGCATCAATTTTGT CCTGCCCAAn GAAGTAGAAA 251 ATGCCGCTTC CGTGCAATCG CTGTTTCAGACGGCATCGCG GCGGGGCAAT 301 GCCGATGCCG CCGTGCTGCT nnnnnnnnnn nnnnnnnnnnnnnnGGAAAT 351 CAGCCTGCGG TCCGACnACA GGCCGGTTTC CGTGnCGAAG CGGCGGGATT401 CGGAACGTTT TCTGCTGTTG GACGGCGGCA ACAGCCGGCT CAAGTGGgCG 451TGGGTGGAAA ACGGCACGTT CGCAACCGTC GGTAGCGCGC CGTACCgCGA 501 TTTGTCGCCTTTGGGCGCGG AGTGGGCGGA AAAGGCGGAT GGAAATGTCC 551 GCATCGTCGG TTGCGCTGTGTGCGGAGAAT TCAAAAAGGC ACAAGTGCAG 601 GAACAGCTCG CCCGAAAAAT CGAGTGGCTGCCGTCTTCCG CACAGGCTTT 651 GTTTGGCATA CGCAACCACT ACCGCCACCC CGAAGAACACGGTTCCGACC 701 GCTGGTTCAA CGCCTTGGGC AGCCGCCGCT TCAGCCGCAA CGCyTGCGTC751 GTCGTCAGTT GCGGCACGGC GGTAACGGTT GACGCGCTCA CCGATGACGG 801ACATTATCTC GGrgGAACCA TCATGCCCGG TTTCCACCTG ATGAAAGAAT 851 CGCTCGCCGTCCGAACCGCC AACCTCAACC GGCACGCCGG TAAGCGTTAT 901 CCTTTCCCGA CCACAACGGGCAATGCCGTC GCCAGCGGCA TGATGGATGC 951 GGTTTGCGGC TCGGTTATGA TGATGCACGGGCGTTTGAAA GAAAAAACCG 1001 GGGCGGGCAA GCCTGTCGAT GTCATCATTA CCGGCGGCGGCGCGGCAAAA 1051 GTTGCCGAAG CCCTGCCGCC TGCATTTTTG GCGGAAAATA CCGTGCGCGT1101 GGCGGACAAC CTCGTCATTT ACGGGTTGTT GAACATGATT GCCGCCGAAG 1151GCAGGGAATA TGAACAT....This corresponds to the amino acid sequence <SEQ ID 1292; ORF 311>:

m311.pep (partial) 1 MFSFGWVFDR PQYELGSLSP VAAVACRRAL SRLGLDVQIKWPNDLVVGRD 51 KLGGILIETV RTGGKTVAVV GIGINFVLPX EVENAASVQS LFQTASRRGN 101ADAAVLLXXX XXXXXEISLR SDXRPVSVXK RRDSERFLLL DGGNSRLKWA 151 WVENGTFATVGSAPYRDLSP LGAEWAEKAD GNVRIVGCAV CGEFKKAQVQ 201 EQLARKIEWL PSSAQALFGIRNHYRHPEEH GSDRWFNALG SRRFSRNACV 251 VVSCGTAVTV DALTDDGHYL GGTIMPGFHLMKESLAVRTA NLNRHAGKRY 301 PFPTTTGNAV ASGMMDAVCG SVMMMHGRLK EKTGAGKPVDVIITGGGAAK 351 VAEALPPAFL AENTVRVADN LVIYGLLNMI AAEGREYEH....Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae ORF 311 shows 78.5%identity over a 455 aa overlap with a predicted ORF (ORF 311.ng) from N.gonorrhoeae:

m311/g311           10        20        30        40        50        60m311.pep   MFSFGWVFDRPQYELGSLSPVAAVACRRALSRLGLDVQIKWPNDLVVGRDKLGGILIETV  ||||||:||||||||||||||||:||||||: |||::||||||||||||||||||||||| g311  MFSFGWAFDRPQYELGSLSPVAALACRRALGCLGLETQIKWPNDLVVGRDKLGGILIETV          10        20        30        40        50        60          70        80        90       100       110 m311.pep  RAGGKTVAVVGIGINFVLPXEVENAASVQSLFQTASRRGNADAAVLLXXX----------  |:||||||||||||||||| ||||||||||||||||||||||||||| : g311  RAGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADAAVLLETLLAELGAVLEQ          70        80        90       100       110       120 m311.pep  --------------------------------------------------------XXXX                                                          : g311  YAEEGFAPFLNEYETANRDHGKAVLLLRDGETVCEGTVKGVDGRGVLHLETAEGEQTVVS         130       140       150       160       170       180     120       130       140       150       160       170 m311.pep  XEISLRSDXRPVSVXKRRDSERFLLLDGGNSRLKWAWVENGTFATVGSAPYRDLSPLGAE   ||||| | | ||| || ||||||||:||||||||||||||||||||||||||||||||| g311  GEISLRPDNRSVSVPKRPDSERFLLLEGGNSRLKWAWVENGTFATVGSAPYRDLSPLGAE         190       200       210       220       230       240     180       190       200       210       220       230 m311.pep  WAEKADGNVRIVGCAVCGEFKKAQVQEQLARKIEWLPSSAQALFGIRNHYRHPEEHGSDR  ||||||||||||||||||| |||||:||||||||||||||||| |||||||||||||||| g311  WAEKADGNVRIVGCAVCGESKKAQVKEQLARKIEWLPSSAQAL-GIRNHYRHPEEHGSDR         250       260       270       280        290     240       250       260       270       280       290 m311.pep  WFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGFHLMKESLAVRTANLNR  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g311  WFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGFHLMKESLAVRTANLNR300       310       320       330       340       350     300       310       320       330       340       350 m311.pep  HAGKRYPFPTTTGNAVASGMMDAVCGSVMMMHGRLKEKTGAGKPVDVIITGGGAAKVAEA   ||||||||||||||||||||||||||:||||||||||:||||||||||||||||||||| g311  PAGKRYPFPTTTGNAVASGMMDAVCGSIMMMHGRLKEKNGAGKPVDVIITGGGAAKVAEA360       370       380       390       400       410     360       370       380      389 m311.pep  LPPAFLAENTVRVADNLVIYGLLNMIAAEGREYEH  |||||||||||||||||||:||||:||||| | || g311  LPPAFLAENTVRVADNLVIHGLLNLIAAEGGESEHAX420       430       440       450The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1293>:

a311.seq 1 ATGTTCAGTT TTGGCTGGGT GTTTGACCGG CCGCAGTATG AGTTGGGTTC 51GCTGTCGCCT GTTGCGGCAG TGGCGTGCCG GCGCGCCTTG TCGCGTTTGG 101 GTTTGAAAACGCAAATCAAG TGGCCAAACG ATTTGGTCGT CGGACGCGAC 151 AAATTGGGCG GCATTCTGATTGAAACGGTC AGGACGGGCG GCAAAACGGT 201 TGCCGTGGTC GGTATCGGCA TCAATTTCGTGCTGCCCAAG GAAGTGGAAA 251 ACGCCGCTTC CGTGCAATCG CTGTTTCAGA CGGCATCGCGGCGGGGAAAT 301 GCCGATGCCG CCGTGTTGCT GGAAACGCTG TTGGCGGAAC TTGATGCGGT351 GTTGTTGCAA TATGCGCGGG ACGGATTTGC GCCTTTTGTG GCGGAATATC 401AGGCTGCCAA CCGCGACCAC GGCAAGGCGG TATTGCTGTT GCGCGACGGC 451 GAAACCGTGTTCGAAGGCAC GGTTAAAGGC GTGGACGGAC AAGGCGTTCT 501 GCACTTGGAA ACGGCAGAGGGCAAACAGAC GGTCGTCAGC GGCGAAATCA 551 GCCTGCGGTC CGACGACAGG CCGGTTTCCGTGCCGAAGCG GCGGGATTCG 601 GAACGTTTTC TGCTGTTGGA CGGCGGCAAC AGCCGGCTCAAGTGGGCGTG 651 GGTGGAAAAC GGCACGTTCG CAACCGTCGG TAGCGCGCCG TACCGCGATT701 TGTCGCCTTT GGGCGCGGAG TGGGCGGAAA AGGTGGATGG AAATGTCCGC 751ATCGTCGGTT GCGCCGTGTG CGGAGAATTC AAAAAGGCAC AAGTGCAGGA 801 ACAGCTCGCCCGAAAAATCG AGTGGCTGCC GTCTTCCGCA CAGGCTTTGG 851 GCATACGCAA CCACTACCGCCACCCCGAAG AACACGGTTC CGACCGCTGG 901 TTCAACGCCT TGGGCAGCCG CCGCTTCAGCCGCAACGCCT GCGTCGTCGT 951 CAGTTGCGGC ACGGCGGTAA CGGTTGACGC GCTCACCGATGACGGACATT 1001 ATCTCGGGGG AACCATCATG CCCGGTTTCC ACCTGATGAA AGAATCGCTC1051 GCCGTCCGAA CCGCCAACCT CAACCGGCAC GCCGGTAAGC GTTATCCTTT 1101CCCGACCACA ACGGGCAATG CCGTCGCCAG CGGCATGATG GATGCGGTTT 1151 GCGGCTCGGTTATGATGATG CACGGGCGTT TGAAAGAAAA AACCGGGGCG 1201 GGCAAGCCTG TCGATGTCATCATTACCGGC GGCGGCGCGG CAAAAGTTGC 1251 CGAAGCCCTG CCGCCTGCAT TTTTGGCGGAAAATACCGTG CGCGTGGCGG 1301 ACAACCTCGT CATTCACGGG CTGCTGAACC TGATTGCCGCCGAAGGCGGG 1351 GAATCGGAAC ATACTTAAThis corresponds to the amino acid sequence <SEQ ID 1294; ORF 311.a>:

a311.pep 1 MFSFGWVFDR PQYELGSLSP VAAVACRRAL SRLGLKTQIK WPNDLVVGRD 51KLGGILIETV RTGGKTVAVV GIGINFVLPK EVENAASVQS LFQTASRRGN 101ADAAVLLETL LAELDAVLLQ YARDGFAPFV AEYQAANRDH GKAVLLLRDG 151 ETVFEGTVKGVDGQGVLHLE TAEGKQTVVS GEISLRSDDR PVSVPKRRDS 201 ERFLLLDGGN SRLKWAWVENGTFATVGSAP YRDLSPLGAE WAEKVDGNVR 251 IVGCAVCGEF KKAQVQEQLA RKIEWLPSSAQALGIRNHYR HPEEHGSDRW 301 FNALGSRRFS RNACVVVSCG TAVTVDALTD DGHYLGGTIMPGFHLMKESL 351 AVRTANLNRH AGKRYPFPTT TGNAVASGMM DAVCGSVMMM HGRLKEKTGA401 GKPVDVIITG GGAAKVAEAL PPAFLAENTV RVADNLVIHG LLNLIAAEGG 451 ESEHT*m311/a311 81.3% identity in 455 aa overlap          10        20        30        40        50        60 m311.pep  MFSFGWVFDRPQYELGSLSPVAAVACRRALSRLGLDVQIKWPNDLVVGRDKLGGILIETV  ||||||||||||||||||||||||||||||||||| :||||||||||||||||||||||| a311  MFSFGWVFDRPQYELGSLSPVAAVACRRALSRLGLKTQIKWPNDLVVGRDKLGGILIETV          10        20        30        40        50        60          70        80        90       100       110 m311.pep  RTGGKTVAVVGIGINFVLPXEVENAASVQSLFQTASRRGNADAAVLLXXXXXXXX-----  ||||||||||||||||||| ||||||||||||||||||||||||||| : a311  RTGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADAAVLLETLLAELDAVLLQ          70        80        90       100       110       120 m311.pep  ------------------------------------------------------------ a311  YARDGFAPFVAEYQAANRDHGKAVLLLRDGETVFEGTVKGVDGQGVLHLETAEGKQTVVS         130       140       150       160       170       180     120       130       140       150       160       170 m311.pep  -EISLRSDXRPVSVXKRRDSERFLLLDGGNSRLKWAWVENGTFATVGSAPYRDLSPLGAE   ||||||| ||||| ||||||||||||||||||||||||||||||||||||||||||||| a311  GEISLRSDDRPVSVPKRRDSERFLLLDGGNSRLKWAWVENGTFATVGSAPYRDLSPLGAE         190       200       210       220       230       240     180       190       200       210       220       230 m311.pep  WAEKADGNVRIVGCAVCGEFKKAQVQEQLARKIEWLPSSAQALFGIRNHYRHPEEHGSDR  ||||:|||||||||||||||||||||||||||||||||||||| |||||||||||||||| a311  WAEKVDGNVRIVGCAVCGEFKKAQVQEQLARKIEWLPSSAQAL-GIRNHYRHPEEHGSDR         250       260       270       280        290     240       250       260       270       280       290 m311.pep  WFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGFHLMKESLAVRTANLNR  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a311  WFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGFHLMKESLAVRTANLNR300       310       320       330       340       350     300       310       320       330       340       350 m311.pep  HAGKRYPFPTTTGNAVASGMMDAVCGSVMMMHGRLKEKTGAGKPVDVIITGGGAAKVAEA  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a311  HAGKRYPFPTTTGNAVASGMMDAVCGSVMMMHGRLKEKTGAGKPVDVIITGGGAAKVAEA360       370       380       390       400       410     360       370       380      389 m311.pep  LPPAFLAENTVRVADNLVIYGLLNMIAAEGREYEH  |||||||||||||||||||:||||:||||| | || a311  LPPAFLAENTVRVADNLVIHGLLNLIAAEGGESEHTX420       430       440       450The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1295>:

g311-1.seq 1 ATGACGGTTT TGAAGCCTTC GCATTGGCGG GTGTTGGCGG AGCTTGCCGA 51CGGTTTGCCG CAACACGTAT CGCAATTGGC GCGTGAGGCG GACATGAAGC 101 CGCAGCAGCTCAACGGTTTT TGGCAGCAGA TGCCGGCGCA TATACGCGGG 151 CTGTTGCGCC AACACGACGGCTATTGGCGG CTGGTGCGCC CCTTGGCGGT 201 TTTCGATGCC GAAGGTTTGC GCGATCTGGGGGAAAGGTCG GGTTTTCAGA 251 CGGCATTGAA GCACGAGTGC GCGTCCAGCA ACGACGAGATACTGGAATTG 301 GCGCGGATTG CGCCGGACAA GGCGCACAAA ACCATATGCG TGACCCACCT351 GCAAAGTAAG GGCAGGGGGC GGCAGGGGCG GAAGTGGTCG CACCGTTTGG 401GCGAGTGCCT GATGTTCAGT TTCGGCTGGG CGTTTGACCG GCCGCAGTAT 451 GAGTTGGGTTCGCTGTCGCC TGTTGCGGCA CTTGCGTGCC GGCGCGCTTT 501 GGGGTGTTTG GGTTTGGAAACGCAAATCAA GTGGCCAAAC GATTTGGTCG 551 TCGGACGCGA CAAATTGGGC GGCATTCTGATTGAAACAGT CAGGGCGGGC 601 GGTAAAACGG TTGCCGTGGT CGGTATCGGC ATCAATTTCGTGCTGCCCAA 651 GGAAGTGGAA AACGCCGCTT CCGTGCAGTC GCTGTTTCAG ACGGCATCGC701 GGCGGGGCAA TGCCGATGCC GCCGTATTGC TGGAAACATT GCTTGCGGAA 751CTGGGCGCGG TGTTGGAACA ATATGCGGAA GAAGGGTTCG CGCCATTTTT 801 AAATGAGTATGAAACGGCCA ACCGCGACCA CGGCAAGGCG GTATTGCTGT 851 TGCGCGACGG CGAAACCGTGTGCGAAGGCA CGGTTAAAGG CGTGGACGGA 901 CGAGGCGTTC TGCACTTGGA AACGGCAGaaggCGAACAGa cggtcGtcag 951 cggcGaaaTC AGccTGCGGc CCGacaacag gtcggtttccGTgccgaagc 1001 gGccggatTC GgaacgttTT tTGCTgttgg aaggcgggaa cagccggctc1051 aAGTGGgcgt gGGTggAAAA Cggcacgttc gcaaccgtgg gcAGCGCgCC 1101gtaCCGCGAT TTGTCGCCTT TGGGCGCGGA GTGGGCGGAA AAGGCGGATG 1151 GAAATGTCCGCATCGTCGGT TGCGCCGTGT GCGGAGAATC CAAAAAGGCA 1201 CAAGTGAAGG AACAGCTCGCCCGAAAAATC GAGTGGCTGC CGTCTTCCGC 1251 ACAGGCTTTG GGCATACGCA ACCACTACCGCCACCCCGAA GAACACGGTT 1301 CCGACCGTTG GTTCAACGCC TTGGGCAGCC GCCGCTTCAGCCGCAACGCC 1351 TGCGTCGTCG TCAGTTGCGG CACGGCGGTA ACGGTTGACG CGCTCACCGA1401 TGACGGACAT TATCTCGGCG GAACCATCAT GCCCGGCTTC CACCTGATGA 1451AAGAATCGCT CGCCGTCCGA ACCGCCAACC TCAACCGCCC CGCCGGCAAA 1501 CGTTACCCTTTCCCGACCAC AACGGGCAAC GCCGTCGCAA GCGGCATGAT 1551 GGACGCGGTT TGCGGCTCGATAATGATGAT GCACGGCCGT TTGAAAGAAA 1601 AAAACGGCGC GGGCAAGCCT GTCGATGTCATCATTACCGG CGGCGGCGCG 1651 GCGAAAGTCG CCGAAGCCCT GCCGCCTGCA TTTTTGGCGGAAAATACCGT 1701 GCGCGTGGCG GACAACCTCG TCATCCACGG GCTGCTGAAC CTGATTGCCG1751 CCGAAGGCGG GGAATCGGAA CACGCTTAAThis corresponds to the amino acid sequence <SEQ ID 1296; ORF 311-1.ng>:

g311-1.pep 1 MTVLKPSHWR VLAELADGLP QHVSQLAREA DMKPQQLNGF WQQMPAHIRG 51LLRQHDGYWR LVRPLAVFDA EGLRDLGERS GFQTALKHEC ASSNDEILEL 101 ARIAPDKAHKTICVTHLQSK GRGRQGRKWS HRLGECLMFS FGWAFDRPQY 151 ELGSLSPVAA LACRRALGCLGLETQIKWPN DLVVGRDKLG GILIETVRAG 201 GKTVAVVGIG INFVLPKEVE NAASVQSLFQTASRRGNADA AVLLETLLAE 251 LGAVLEQYAE EGFAPFLNEY ETANRDHGKA VLLLRDGETVCEGTVKGVDG 301 RGVLHLETAE GEQTVVSGEI SLRPDNRSVS VPKRPDSERF LLLEGGNSRL351 KWAWVENGTF ATVGSAPYRD LSPLGAEWAE KADGNVRIVG CAVCGESKKA 401QVKEQLARKI EWLPSSAQAL GIRNHYRHPE EHGSDRWFNA LGSRRFSRNA 451CVVVSCGTAV TVDALTDDGH YLGGTIMPGF HLMKESLAVR TANLNRPAGK 501 RYPFPTTTGNAVASGMMDAV CGSIMMMHGR LKEKNGAGKP VDVIITGGGA 551 AKVAEALPPA FLAENTVRVADNLVIHGLLN LIAAEGGESE HA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1297>:

m311-1.seq 1 ATGACGGTTT TGAAGCTTTC GCACTGGCGG GTGTTGGCGG AGCTTGCCGA 51CGGTTTGCCG CAACACGTCT CGCAACTGGC GCGTATGGCG GATATGAAGC 101 CGCAGCAGCTCAACGGTTTT TGGCAGCAGA TGCCGGCGCA CATACGCGGG 151 CTGTTGCGCC AACACGACGGCTATTGGCGG CTGGTGCGCC CATTGGCGGT 201 TTTCGATGCC GAAGGTTTGC GCGAGCTGGGGGAAAGGTCG GGTTTTCAGA 251 CGGCATTGAA GCACGAGTGC GCGTCCAGCA ACGACGAGATACTGGAATTG 301 GCGCGGATTG CGCCGGACAA GGCGCACAAA ACCATATGCG TGACCCACCT351 GCAAAGTAAG GGCAGGGGGC GGCAGGGGCG GAAGTGGTCG CACCGTTTGG 401GCGAGTGTCT GATGTTCAGT TTTGGCTGGG TGTTTGACCG GCCGCAGTAT 451 GAGTTGGGTTCGCTGTCGCC TGTTGCGGCA GTGGCGTGTC GGCGCGCCTT 501 GTCGCGTTTA GGTTTGGATGTGCAGATTAA GTGGCCCAAT GATTTGGTTG 551 TCGGACGCGA CAAATTGGGC GGCATTCTGATTGAAACGGT CAGGACGGGC 601 GGCAAAACGG TTGCCGTGGT CGGTATCGGC ATCAATTTTGTCCTGCCCAA 651 GGAAGTAGAA AATGCCGCTT CCGTGCAATC GCTGTTTCAG ACGGCATCGC701 GGCGGGGCAA TGCCGATGCC GCCGTGCTGC TGGAAACGCT GTTGGTGGAA 751CTGGACGCGG TGTTGTTGCA ATATGCGCGG GACGGATTTG CGCCTTTTGT 801 GGCGGAATATCAGGCTGCCA ACCGCGACCA CGGCAAGGCG GTATTGCTGT 851 TGCGCGACGG CGAAACCGTGTTCGAAGGCA CGGTTAAAGG CGTGGACGGA 901 CAAGGCGTTT TGCACTTGGA AACGGCAGAGGGCAAACAGA CGGTCGTCAG 951 CGGCGAAATC AGCCTGCGGT CCGACGACAG GCCGGTTTCCGTGCCGAAGC 1001 GGCGGGATTC GGAACGTTTT CTGCTGTTGG ACGGCGGCAA CAGCCGGCTC1051 AAGTGGGCGT GGGTGGAAAA CGGCACGTTC GCAACCGTCG GTAGCGCGCC 1101GTACCGCGAT TTGTCGCCTT TGGGCGCGGA GTGGGCGGAA AAGGCGGATG 1151 GAAATGTCCGCATCGTCGGT TGCGCTGTGT GCGGAGAATT CAAAAAGGCA 1201 CAAGTGCAGG AACAGCTCGCCCGAAAAATC GAGTGGCTGC CGTCTTCCGC 1251 ACAGGCTTTG GGCATACGCA ACCACTACCGCCACCCCGAA GAACACGGTT 1301 CCGACCGCTG GTTCAACGCC TTGGGCAGCC GCCGCTTCAGCCGCAACGCC 1351 TGCGTCGTCG TCAGTTGCGG CACGGCGGTA ACGGTTGACG CGCTCACCGA1401 TGACGGACAT TATCTCGGGG GAACCATCAT GCCCGGTTTC CACCTGATGA 1451AAGAATCGCT CGCCGTCCGA ACCGCCAACC TCAACCGGCA CGCCGGTAAG 1501 CGTTATCCTTTCCCGACCAC AACGGGCAAT GCCGTCGCCA GCGGCATGAT 1551 GGATGCGGTT TGCGGCTCGGTTATGATGAT GCACGGGCGT TTGAAAGAAA 1601 AAACCGGGGC GGGCAAGCCT GTCGATGTCATCATTACCGG CGGCGGCGCG 1651 GCAAAAGTTG CCGAAGCCCT GCCGCCTGCA TTTTTGGCGGAAAATACCGT 1701 GCGCGTGGCG GACAACCTCG TCATTTACGG GTTGTTGAAC ATGATTGCCG1751 CCGAAGGCAG GGAATATGAA CATATTTAAThis corresponds to the amino acid sequence <SEQ ID 1298; ORF 311-1>:

m311-1.pep 1 MTVLKLSHWR VLAELADGLP QHVSQLARMA DMKPQQLNGF WQQMPAHIRG 51LLRQHDGYWR LVRPLAVFDA EGLRELGERS GFQTALKHEC ASSNDEILEL 101 ARIAPDKAHKTICVTHLQSK GRGRQGRKWS HRLGECLMFS FGWVFDRPQY 151 ELGSLSPVAA VACRRALSRLGLDVQIKWPN DLVVGRDKLG GILIETVRTG 201 GKTVAVVGIG INFVLPKEVE NAASVQSLFQTASRRGNADA AVLLETLLVE 251 LDAVLLQYAR DGFAPFVAEY QAANRDHGKA VLLLRDGETVFEGTVKGVDG 301 QGVLHLETAE GKQTVVSGEI SLRSDDRPVS VPKRRDSERF LLLDGGNSRL351 KWAWVENGTF ATVGSAPYRD LSPLGAEWAE KADGNVRIVG CAVCGEFKKA 401QVQEQLARKI EWLPSSAQAL GIRNHYRHPE EHGSDRWFNA LGSRRFSRNA 451CVVVSCGTAV TVDALTDDGH YLGGTIMPGF HLMKESLAVR TANLNRHAGK 501 RYPFPTTTGNAVASGMMDAV CGSVMMMHGR LKEKTGAGKP VDVIITGGGA 551 AKVAEALPPA FLAENTVRVADNLVIYGLLN MIAAEGREYE HI* m311-1/g311-1 93.9% identity in 591 aa overlap        10        20        30        40        50        60 m311-1.pepMTVLKLSHWRVLAELADGLPQHVSQLARMADMKPQQLNGFWQQMPAHIRGLLRQHDGYWR||||| |||||||||||||||||||||| ||||||||||||||||||||||||||||||| g311-1MTVLKPSHWRVLAELADGLPQHVSQLAREADMKPQQLNGFWQQMPAHIRGLLRQHDGYWR        10        20        30        40        50        60        70        80        90       100       110       120 m311-1.pepLVRPLAVFDAEGLRELGERSGFQTALKHECASSNDEILELARIAPDKAHKTICVTHLQSK||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||| g311-1LVRPLAVFDAEGLRDLGERSGFQTALKHECASSNDEILELARIAPDKAHKTICVTHLQSK        70        80        90       100       110       120       130       140       150       160       170       180 m311-1.pepGRGRQGRKWSHRLGECLMFSFGWVFDRPQYELGSLSPVAAVACRRALSRLGLDVQIKWPN|||||||||||||||||||||||:||||||||||||||||:||||||: |||::|||||| g311-1GRGRQGRKWSHRLGECLMFSFGWAFDRPQYELGSLSPVAALACRRALGCLGLETQIKWPN       130       140       150       160       170       180       190       200       210       220       230       240 m311-1.pepDLVVGRDKLGGILIETVRTGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADA||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||| g311-1DLVVGRDKLGGILIETVRAGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADA       190       200       210       220       230       240       250       260       270       280       290       300 m311-1.pepAVLLETLLVELDAVLLQYARDGFAPFVAEYQAANRDHGKAVLLLRDGETVFEGTVKGVDG||||||||:|| ||| |||::|||||: ||::|||||||||||||||||| ||||||||| g311-1AVLLETLLAELGAVLEQYAEEGFAPFLNEYETANRDHGKAVLLLRDGETVCEGTVKGVDG       250       260       270       280       290       300       310       320       330       340       350       360 m311-1.pepQGVLHLETAEGKQTVVSGEISLRSDDRPVSVPKRRDSERFLLLDGGNSRLKWAWVENGTF:||||||||||:||||||||||| |:| |||||| ||||||||:|||||||||||||||| g311-1RGVLHLETAEGEQTVVSGEISLRPDNRSVSVPKRPDSERFLLLEGGNSRLKWAWVENGTF       310       320       330       340       350       360       370       380       390       400       410       420 m311-1.pepATVGSAPYRDLSPLGAEWAEKADGNVRIVGCAVCGEFKKAQVQEQLARKIEWLPSSAQAL|||||||||||||||||||||||||||||||||||| |||||:||||||||||||||||| g311-1ATVGSAPYRDLSPLGAEWAEKADGNVRIVGCAVCGESKKAQVKEQLARKIEWLPSSAQAL       370       380       390       400       410       420       430       440       450       460       470       480 m311-1.pepGIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g311-1GIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGF       430       440       450       460       470       480       490       500       510       520       530       540 m311-1.pepHLMKESLAVRTANLNRHAGKRYPFPTTTGNAVASGMMDAVCGSVMMMHGRLKEKTGAGKP|||||||||||||||| ||||||||||||||||||||||||||:||||||||||:||||| g311-1HLMKESLAVRTANLNRPAGKRYPFPTTTGNAVASGMMDAVCGSIMMMHGRLKEKNGAGKP       490       500       510       520       530       540       550       560       570       580       590 m311-1.pepVDVIITGGGAAKVAEALPPAFLAENTVRVADNLVIYGLLNMIAAEGREYEHIX|||||||||||||||||||||||||||||||||||:||||:||||| | || g311-1VDVIITGGGAAKVAEALPPAFLAENTVRVADNLVIHGLLNLIAAEGGESEHAX       550       560       570       580       590The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1299>:

a311-1.seq 1 ATGACGGTTT TGAAGCCTTC GCACTGGCGG GTGTTGGCGG AGCTTGCCGA 51CGGTTTGCCG CAACACGTCT CGCAACTGGC GCGTATGGCG GATATGAAGC 101 CGCAGCAGCTCAACGGTTTT TGGCAGCAGA TGCCGGCGCA CATACGCGGG 151 CTGTTGCGCC AACACGACGGCTATTGGCGG CTGGTGCGCC CATTGGCGGT 201 TTTCGATGCC GAAGGTTTGC GCGAGCTGGGGGAAAGGTCG GGTTTTCAGA 251 CGGCATTGAA GCACGAGTGC GCGTCCAGCA ACGACGAGATACTGGAATTG 301 GCGCGGATTG CGCCGGACAA GGCGCACAAA ACCATATGTG TGACCCACCT351 GCAAAGTAAG GGCAGGGGGC GGCAGGGGCG GAAGTGGTCG CACCGTTTGG 401GCGAGTGTCT GATGTTCAGT TTTGGCTGGG TGTTTGACCG GCCGCAGTAT 451 GAGTTGGGTTCGCTGTCGCC TGTTGCGGCA GTGGCGTGCC GGCGCGCCTT 501 GTCGCGTTTG GGTTTGAAAACGCAAATCAA GTGGCCAAAC GATTTGGTCG 551 TCGGACGCGA CAAATTGGGC GGCATTCTGATTGAAACGGT CAGGACGGGC 601 GGCAAAACGG TTGCCGTGGT CGGTATCGGC ATCAATTTCGTGCTGCCCAA 651 GGAAGTGGAA AACGCCGCTT CCGTGCAATC GCTGTTTCAG ACGGCATCGC701 GGCGGGGAAA TGCCGATGCC GCCGTGTTGC TGGAAACGCT GTTGGCGGAA 751CTTGATGCGG TGTTGTTGCA ATATGCGCGG GACGGATTTG CGCCTTTTGT 801 GGCGGAATATCAGGCTGCCA ACCGCGACCA CGGCAAGGCG GTATTGCTGT 851 TGCGCGACGG CGAAACCGTGTTCGAAGGCA CGGTTAAAGG CGTGGACGGA 901 CAAGGCGTTC TGCACTTGGA AACGGCAGAGGGCAAACAGA CGGTCGTCAG 951 CGGCGAAATC AGCCTGCGGT CCGACGACAG GCCGGTTTCCGTGCCGAAGC 1001 GGCGGGATTC GGAACGTTTT CTGCTGTTGG ACGGCGGCAA CAGCCGGCTC1051 AAGTGGGCGT GGGTGGAAAA CGGCACGTTC GCAACCGTCG GTAGCGCGCC 1101GTACCGCGAT TTGTCGCCTT TGGGCGCGGA GTGGGCGGAA AAGGTGGATG 1151 GAAATGTCCGCATCGTCGGT TGCGCCGTGT GCGGAGAATT CAAAAAGGCA 1201 CAAGTGCAGG AACAGCTCGCCCGAAAAATC GAGTGGCTGC CGTCTTCCGC 1251 ACAGGCTTTG GGCATACGCA ACCACTACCGCCACCCCGAA GAACACGGTT 1301 CCGACCGCTG GTTCAACGCC TTGGGCAGCC GCCGCTTCAGCCGCAACGCC 1351 TGCGTCGTCG TCAGTTGCGG CACGGCGGTA ACGGTTGACG CGCTCACCGA1401 TGACGGACAT TATCTCGGGG GAACCATCAT GCCCGGTTTC CACCTGATGA 1451AAGAATCGCT CGCCGTCCGA ACCGCCAACC TCAACCGGCA CGCCGGTAAG 1501 CGTTATCCTTTCCCGACCAC AACGGGCAAT GCCGTCGCCA GCGGCATGAT 1551 GGATGCGGTT TGCGGCTCGGTTATGATGAT GCACGGGCGT TTGAAAGAAA 1601 AAACCGGGGC GGGCAAGCCT GTCGATGTCATCATTACCGG CGGCGGCGCG 1651 GCAAAAGTTG CCGAAGCCCT GCCGCCTGCA TTTTTGGCGGAAAATACCGT 1701 GCGCGTGGCG GACAACCTCG TCATTCACGG GCTGCTGAAC CTGATTGCCG1751 CCGAAGGCGG GGAATCGGAA CATACTTAAThis corresponds to the amino acid sequence <SEQ ID 1300; ORF 311-1.a>:

a311-1.pep 1 MTVLKPSHWR VLAELADGLP QHVSQLARMA DMKPQQLNGF WQQMPAHIRG 51LLRQHDGYWR LVRPLAVFDA EGLRELGERS GFQTALKHEC ASSNDEILEL 101 ARIAPDKAHKTICVTHLQSK GRGRQGRKWS HRLGECLMFS FGWVFDRPQY 151 ELGSLSPVAA VACRRALSRLGLKTQIKWPN DLVVGRDKLG GILIETVRTG 201 GKTVAVVGIG INFVLPKEVE NAASVQSLFQTASRRGNADA AVLLETLLAE 251 LDAVLLQYAR DGFAPFVAEY QAANRDHGKA VLLLRDGETVFEGTVKGVDG 301 QGVLHLETAE GKQTVVSGEI SLRSDDRPVS VPKRRDSERF LLLDGGNSRL351 KWAWVENGTF ATVGSAPYRD LSPLGAEWAE KVDGNVRIVG CAVCGEFKKA 401QVQEQLARKI EWLPSSAQAL GIRNHYRHPE EHGSDRWFNA LGSRRFSRNA 451CVVVSCGTAV TVDALTDDGH YLGGTIMPGF HLMKESLAVR TANLNRHAGK 501 RYPFPTTTGNAVASGMMDAV CGSVMMMHGR LKEKTGAGKP VDVIITGGGA 551 AKVAEALPPA FLAENTVRVADNLVIHGLLN LIAAEGGESE HT* a311-1/m311-1 98.5% identity in 591 aa overlap        10        20        30        40        50        60 a311-1.pepMTVLKPSHWRVLAELADGLPQHVSQLARMADMKPQQLNGFWQQMPAHIRGLLRQHDGYWR||||| |||||||||||||||||||||||||||||||||||||||||||||||||||||| m311-1MTVLKLSHWRVLAELADGLPQHVSQLARMADMKPQQLNGFWQQMPAHIRGLLRQHDGYWR        10        20        30        40        50        60        70        80        90       100       110       120 a311-1.pepLVRPLAVFDAEGLRELGERSGFQTALKHECASSNDEILELARIAPDKAHKTICVTHLQSK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m311-1LVRPLAVFDAEGLRELGERSGFQTALKHECASSNDEILELARIAPDKAHKTICVTHLQSK        70        80        90       100       110       120       130       140       150       160       170       180 a311-1.pepGRGRQGRKWSHRLGECLMFSFGWVFDRPQYELGSLSPVAAVACRRALSRLGLKTQIKWPN|||||||||||||||||||||||||||||||||||||||||||||||||||| :|||||| m311-1GRGRQGRKWSHRLGECLMFSFGWVFDRPQYELGSLSPVAAVACRRALSRLGLDVQIKWPN       130       140       150       160       170       180       190       200       210       220       230       240 a311-1.pepDLVVGRDKLGGILIETVRTGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m311-1DLVVGRDKLGGILIETVRTGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADA       190       200       210       220       230       240       250       260       270       280       290       300 a311-1.pepAVLLETLLAELDAVLLQYARDGFAPFVAEYQAANRDHGKAVLLLRDGETVFEGTVKGVDG||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||| m311-1AVLLETLLVELDAVLLQYARDGFAPFVAEYQAANRDHGKAVLLLRDGETVFEGTVKGVDG       250       260       270       280       290       300       310       320       330       340       350       360 a311-1.pepQGVLHLETAEGKQTVVSGEISLRSDDRPVSVPKRRDSERFLLLDGGNSRLKWAWVENGTF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m311-1QGVLHLETAEGKQTVVSGEISLRSDDRPVSVPKRRDSERFLLLDGGNSRLKWAWVENGTF       310       320       330       340       350       360       370       380       390       400       410       420 a311-1.pepATVGSAPYRDLSPLGAEWAEKVDGNVRIVGCAVCGEFKKAQVQEQLARKIEWLPSSAQAL|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| m311-1ATVGSAPYRDLSPLGAEWAEKADGNVRIVGCAVCGEFKKAQVQEQLARKIEWLPSSAQAL       370       380       390       400       410       420       430       440       450       460       470       480 a311-1.pepGIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m311-1GIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGF       430       440       450       460       470       480       490       500       510       520       530       540 a311-1.pepHLMKESLAVRTANLNRHAGKRYPFPTTTGNAVASGMMDAVCGSVMMMHGRLKEKTGAGKP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m311-1HLMKESLAVRTANLNRHAGKRYPFPTTTGNAVASGMMDAVCGSVMMMHGRLKEKTGAGKP       490       500       510       520       530       540       550       560       570       580       590 a311-1.pepVDVIITGGGAAKVAEALPPAFLAENTVRVADNLVIHGLLNLIAAEGGESEHTX|||||||||||||||||||||||||||||||||||:||||:||||| | || m311-1VDVIITGGGAAKVAEALPPAFLAENTVRVADNLVIYGLLNMIAAEGREYEHIX       550       560       570       580       590The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1301>:

g312.seq 1 atgaGtatCc aatCcGgcga AATTTtagaa accgtCAAAA TGGTTGCCGA 51ccggaATttt gAtgtccgCA CCATTAccat cggcaTTgaT ttgcacgact 101 gcatcagcaccgacatcgac gtgttaAACC AAAACATtta caaCAaaaTc 151 accacggtcg gcaaagactTGGTGGCAacg Gcgaaacacc tTTccgcCAA 201 ATACGGCGTG CCGATTGTGA ATCAGCGCATTTCCGTTACG CCGAttgccc 251 AaatcGCGGC GGcgaccaAa gccgaCAGTT AtgtcAGCgtggcgcAGact 301 tTGGACAAGG CAGCCAAAGC CATCGGCGTG TCCTTTATCG GcggCTTTTC351 CGCGCTGGTG CAAAAAGGTA TGTCGCCTTC GGATGAGGTG TTGATCCGTT 401CCGTTCCCGA AGCGATGAAA ACTACCGATA TCGTGTGCAG CTCCATCAAT 451 ATCGGCAGCACGCGTGCCGG TATCAATATG GATGCGGTCA AGCTGGCAGG 501 CGAAACCATC AAACGCACGGCTGAAATCAC ACCCGAAGGT TTCGGCTGCG 551 CCAAAATCGT CGTGTTCTGC AACGCGGTGGAAGACAATCC GTTTATGGCG 601 GGTGCGTTCC ACGGCTCGGG CGAAGCGGAT GCTGTGATTAATGTCGGCGT 651 ATCCGGTCCA GGCGTGGTCA AAGCCGCGCT GGAAAATTCG GACGCGGTCA701 GCCTGACCGA GGTCGCCGAA GTCGTGAAGA AAACCGCTTT CAAAATCACC 751CGCGTGGGCG AACTCATCGG TCGCGAAGCC TCAAAAATGC TGAATATCCC 801 GTTCGGCATTCTCGATTTGT CGCTGGCACC GACCGCCGTC GTCGGCGACT 851 CGGTGGCGCG CATTCTTGAAGAAATGGGCT TGAGCGTCTG CGGTACGCAC 901 GGCACAACAG CAGCTTTGGC ATTGCTGAACGATGCCGTGA AAAAGGGCGG 951 CATGATGGCT TCCAGCGCGG TCGGCGGTTT GAGCGGCGCGTTTATCCCCG 1001 TTTCCGAAGA CGAAGGTATG ATTGCCGCCG CCGAGGCAGG CGTGTTGACG1051 CTGGACAAAC TCGAAGCCAT GACCGCCGTC TGCTCCGTTG GTTTGGACAT 1101GATTGCCGTT CCCGGCGACA CGCCCGCGCA CACCATTTCC GGCATCATCG 1151 CCGACGAAGCCGCCATCGGC ATGATCAACA GCAAAACCAC CGCCGTGCGC 1201 ATTATTCCGG TAACGGGCAAAACCGTCGGC GACAGCGTCG AGTTCGGCGG 1251 TCTGTTGGGC TACGCGCCTG TAATGCCGGCAAAAGAAGGT TCGTGCGAAG 1301 TGTTCGTCAA CCGGGGCGGC AGGATTCCCG CACCGGTTCAATCGATGAAA 1351 AACTGAThis corresponds to the amino acid sequence <SEQ ID 1302; ORF 312.ng>:

g312.pep 1 MSIQSGEILE TVKMVADRNF DVRTITIGID LHDCISTDID VLNQNIYNKI 51TTVGKDLVAT AKHLSAKYGV PIVNQRISVT PIAQIAAATK ADSYVSVAQT 101LDKAAKAIGV SFIGGFSALV QKGMSPSDEV LIRSVPEAMK TTDIVCSSIN 151 IGSTRAGINMDAVKLAGETI KRTAEITPEG FGCAKIVVFC NAVEDNPFMA 201 GAFHGSGEAD AVINVGVSGPGVVKAALENS DAVSLTEVAE VVKKTAFKIT 251 RVGELIGREA SKMLNIPFGI LDLSLAPTPAVGDSVARILE EMGLSVCGTH 301 GTTAALALLN DAVKKGGMMA SSAVGGLSGA FIPVSEDEGMIAAAEAGVLT 351 LDKLEAMTAV CSVGLDMIAV PGDTPAHTIS GIIADEAAIG MINSKTTAVR401 IIPVTGKTVG DSVEFGGLLG YAPVMPAKEG SCEVFVNRGG RIPAPVQSMK 451 N*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1303>:

m312.seq 1 ATGAGTATCC AATCCGGCGA AATTTTAGAA ACCGTCAAAA TGGTTGCCGA 51CCAGAATTTT GATGTCCGCA CCATTACCAT CGGCATTGAT TTGCACGACT 101 GCATCAGCAGCGATATCAAT GTGTTGAACC AAAATATTTA CAATAAAATT 151 ACCACAGTCG GCAAAGACTTGGTCACTACG GCAAAATATC TGTCTGCCAA 201 ATACGGCGTA CCGATTGTGA ATCAGCGCATTTCCGTTACG CCGATTGCCC 251 AAATCGCGGC GGCCACCCAT GCTGATTCTT ACGTCAGCGTGGCGCAAACT 301 TTGGATAAAG CTGCCAAAGC CATCGGTGTG TCTTTTATCG GCGGTTTTTC351 CGCGTTGGTG CAAAAAGGGA TGTCGCcTTC GGATGAGGTG TTAATCCGCT 401CCATTCCCGA AGCGATGAAG ACTACCGATA TTGTGTGCwG CTCCATCAAT 451 ATCGGCAGTACGCGTGCCGG TATCAATATG GATGCGGTCA AGCTGGCGGG 501 CGAAACcGTc AAACGCACGGCGGAAATCAC GCCCGAAGGT TTCGGCTGCG 551 CTAAAATTGT CGTGTTCTGC AACGCGGTGGAAGACAACCC GTTTwTGGCG 601 GGCGCGTTTC ATGGTTCGGG CGATGCCGTT ATCAATGTCGGCGTATCCGG 651 CCCAGGTGTC GTAAAAGCCG CGTTGGAAAA TTCAGATGCA ACGACATTGA701 CCGAAGTTGC GGAAGTAGTG AAGAAAACTG CTTTCAAAAT TACCCGCGTG 751GGCGAACTCA TCGGCCGCGA AGCcTCAAAA ATGCTGAATA TCCCGTTTGG 801 TATTCTCGACTTGTCGCCGA CCCCGCCCGT CGGCGACTCA GTGGCACGCA 851 TTCTTGAAGA AATGGGCTTGAGCGTCTGCG GTACGCACGG CACAACAGCA 901 GCTTTGGCAT TGCTGAACGA TGCCGTGAAAAAAGGCGGCA TGATGGCTTC 951 CAGCGCGGTC GGGGGTTTGA GTGGCGCGTT TATCCCCGTTTCCGAAGACG 1001 AAGGTATGAT yGmCgCcGCC GAAGCAGGCG TGCTGACGCT GGACAAACTC1051 GAAGCCATGA CCGCCGTTTG TTCGGTCGGC TTGGATATGA TTGCCGTTCC 1101CGGCGACACG CCCGCGCACA CCATTTCCGG CATCATTGCC GACGAAGCCG 1151 CCATCGGCAtGATCAACAGC AAAACCACTG CCGTGCGCAT TATTCCGGTA 1201 ACCGGTAAAA CCGTCGGCGACAcGGTCGAG TTCGGCGGCT TGTTGGgCTA 1251 CGCGCCTGTG ATGCCGGTCA AAGAAGGTTCGTGCGAAGTA TTCGTCAACC 1301 GAGGCGGCAG AATTCCGGCT CCGGTTCAAT CGATGAAAAACTGAThis corresponds to the amino acid sequence <SEQ ID 1304; ORF 312>:

m312.pep 1 MSIQSGEILE TVKMVADQNF DVRTITIGID LHDCISSDIN VLNQNIYNKI 51TTVGKDLVTT AKYLSAKYGV PIVNQRISVT PIAQIAAATH ADSYVSVAQT 101LDKAAKAIGV SFIGGFSALV QKGMSPSDEV LIRSIPEAMK TTDIVCXSIN 151 IGSTRAGINMDAVKLAGETV KRTAEITPEG FGCAKIVVFC NAVEDNPFXA 201 GAFHGSGDAV INVGVSGPGVVKAALENSDA TTLTEVAEVV KKTAFKITRV 251 GELIGREASK MLNIPFGILD LSPTPPVGDSVARILEEMGL SVCGTHGTTA 301 ALALLNDAVK KGGMMASSAV GGLSGAFIPV SEDEGMIXAAEAGVLTLDKL 351 EAMTAVCSVG LDMIAVPGDT PAHTISGIIA DEAAIGMINS KTTAVRIIPV401 TGKTVGDTVE FGGLLGYAPV MPVKEGSCEV FVNRGGRIPA PVQSMKN*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 312 shows 95.6% identity over a 451 aa overlap with a predicted ORF(ORF 312.ng) from N. gonorrhoeae:

m312/g312          10        20        30        40        50        60m312.pep  MSIQSGEILETVKMVADQNFDVRTITIGIDLHDCISSDINVLNQNIYNKITTVGKDLVTT |||||||||||||||||:||||||||||||||||||:||:||||||||||||||||||:| g312 MSIQSGEILETVKMVADRNFDVRTITIGIDLHDCISTDIDVLNQNIYNKITTVGKDLVAT         10        20        30        40        50        60         70        80        90       100       110       120 m312.pep AKYLSAKYGVPIVNQRISVTPIAQIAAATHADSYVSVAQTLDKAAKAIGVSFIGGFSALV ||:||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| g312 AKHLSAKYGVPIVNQRISVTPIAQIAAATKADSYVSVAQTLDKAAKAIGVSFIGGFSALV         70        80        90       100       110       120        130       140       150       160       170       180 m312.pep QKGMSPSDEVLIRSIPEAMKTTDIVCXSINIGSTRAGINMDAVKLAGETVKRTAEITPEG ||||||||||||||:||||||||||| ||||||||||||||||||||||:|||||||||| g312 QKGMSPSDEVLIRSVPEAMKTTDIVCSSINIGSTRAGINMDAVKLAGETIKRTAEITPEG        130       140       150       160       170       180        190       200         210       220       230 m312.pep FGCAKIVVFCNAVEDNPFXAGAFHGSG--DAVINVGVSGPGVVKAALENSDATTLTEVAE |||||||||||||||||| ||||||||  |||||||||||||||||||||||::|||||| g312 FGCAKIVVFCNAVEDNPFMAGAFHGSGEADAVINVGVSGPGVVKAALENSDAVSLTEVAE        190       200       210       220       230       240240       250       260       270         280       290 m312.pep VVKKTAFKITRVGELIGREASKMLNIPFGILDLS--PTPPVGDSVARILEEMGLSVCGTH ||||||||||||||||||||||||||||||||||  ||| |||||||||||||||||||| g312 VVKKTAFKITRVGELIGREASKMLNIPFGILDLSLAPTPAVGDSVARILEEMGLSVCGTH        250       260       270       280       290       300  300       310       320       330       340       350 m312.pep GTTAALALLNDAVKKGGMMASSAVGGLSGAFIPVSEDEGMIXAAEAGVLTLDKLEAMTAV ||||||||||||||||||||||||||||||||||||||||| |||||||||||||||||| g312 GITAALALLNDAVKKGGMMASSAVGGLSGAFIPVSEDEGMIAAAEAGVLILDKLEAMTAV        310       320       330       340       350       360  360       370       380       390       400       410 m312.pep CSVGLDMIAVPGDTPAHTISGIIADEAAIGMINSKTTAVRIIPVTGKTVGDTVEFGGLLG |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||| g312 CSVGLDMIAVPGDTPAHTISGIIADEAAIGMINSKTTAVRIIPVIGKTVGDSVEFGGLLG        370       380       390       400       410       420  420       430       440 m312.pep  YAPVMPVKEGSCEVFVNRGGRIPAPVQSMKNX ||||||:||||||||||||||||||||||||| g312  YAPVMPAKEGSCEVFVNRGGRIPAPVQSMKNX        430       440       450The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1305>:

a312.seq 1 ATGAGTATCC AATCCGGCGA AATTTTAGAA ACCGTCAAAA TGGTTGCCGA 51CCAGAATTTC GATGTCCGCA CCATTACCAT CGGCATTGAT TTGCACGACT 101 GCATCAGCACCGACATCGAC GTGTTGAACC AAAATATTTA CAACAAAATT 151 ACCACGGTCG GCAAAGACTTGGTGGCGACA GCAAAATATC TGTCTGCCAA 201 ATACGGCGTG CCGATTGTGA ATCAGCGCATTTCTGTCACG CCGATTGCCC 251 AAATCGCGGC GGCCACCCAT GCTGATTCTT ACGTCAGCGTGGCGCAAACT 301 TTGGATAAGG CTGCCAAAGC CATCGGCGTG TCTTTTATTG GCGGCTTTTC351 CGCGCTGGTG CAAAAAGGTA TGTCGCCTTC TGACGAGGTG TTAATCCGTT 401CCATTCCCGA AGCGATGAAG ACTACTGATA TCGTGTGCAG CTCCATCAAT 451 ATCGGCAGTACGCGCGCCGG TATCAATATG GACGCGGTCA GACTGGCGGG 501 CGAAACCATC AAACGCACGGCTGAAATCAC ACTAGAAGGT TTCGGCTGCG 551 CCAAAATCGT CGTGTTCTGC AACGCGGTGGAAGACAACCC GTTTATGGCG 601 GGCGCGTTTC ACGGCTCAGG CGAAGCGGAT GCTGTGATTAATGTCGGCGT 651 ATCCGGCCCG GGTGTCGTAA AAGCCGCGTT GGAAAATTCG GATGCAACGA701 CATTGACCGA AGTTGCCGAA GTTGTGAAGA AAACCGCCTT CAAAATTACC 751CGCGTGGGCG AACTCATCGG CCGCGAAGCC TCAAAAATGC TGAATATCCC 801 GTTTGGTATTCTCGACTTGT CGCTGGCACC GACCCCTGCC GTCGGCGACT 851 CGGTGGCGCG CATTCTTGAAGAAATGGGTT TGAGCGTCTG CGGTACGCAC 901 GGCACAACAG CAGCTTTGGC ATTGCTGAACGATGCCGTGA AAAAGGGCGG 951 CATGATGGCT TCGAGCGCGG TTGGCGGTTT GAGTGGCGCGTTTATCCCCG 1001 TTTCCGAAGA CGAAGGTATG ATTGCCGCCG CCGAAGCAGG CGTGCTGACG1051 TTGGATAAAC TCGAAGCGAT GACCGCCGTT TGTTCGGTCG GCTTGGATAT 1101GATTGCCGTT CCCGGCGACA CACCCGCGCA CACCATTTCC GGCATCATTG 1151 CCGACGAAGCCGCCATCGGC ATGATCAACA GCAAAACCAC TGCCGTGCGC 1201 ATTATTCCGG TAACCGGTAAAACCGTCGGC GACAGCGTCG AGTTCGGCGG 1251 CCTGTTGGGC TACGCGCCTG TAATGCCGGTAAAAGAAGGC TCATGCGAAG 1301 TGTTCGTCAA CCGGGGCGGC AGGATTCCCG CACCGGTTCAATCGATGAAA 1351 AACTGAThis corresponds to the amino acid sequence <SEQ ID 1306; ORF 312.a>:

a312.pep 1 MSIQSGEILE TVKMVADQNF DVRTITIGID LHDCISTDID VLNQNIYNKI 51TTVGKDLVAT AKYLSAKYGV PIVNQRISVT PIAQIAAATH ADSYVSVAQT 101LDKAAKAIGV SFIGGFSALV QKGMSPSDEV LIRSIPEAMK TTDIVCSSIN 151 IGSTRAGINMDAVRLAGETI KRTAEITLEG FGCAKIVVFC NAVEDNPFMA 201 GAFHGSGEAD AVINVGVSGPGVVKAALENS DATTLTEVAE VVKKTAFKIT 251 RVGELIGREA SKMLNIPFGI LDLSLAPTPAVGDSVARILE EMGLSVCGTH 301 GTTAALALLN DAVKKGGMMA SSAVGGLSGA FIPVSEDEGMIAAAEAGVLT 351 LDKLEAMTAV CSVGLDMIAV PGDTPAHTIS GIIADEAAIG MINSKTTAVR401 IIPVTGKTVG DSVEFGGLLG YAPVMPVKEG SCEVFVNRGG RIPAPVQSMK 451 N*m312/a312 96.7% identity in 451 aa overlap         10        20        30        40        50        60 m312.pep MSIQSGEILETVKMVADQNFDVRTITIGIDLHDCISSDINVLNQNIYNKITTVGKDLVTT ||||||||||||||||||||||||||||||||||||:||:||||||||||||||||||:| a312 MSIQSGEILETVKMVADQNFDVRTITIGIDLHDCISTDIDVLNQNIYNKITTVGKDLVAT         10        20        30        40        50        60         70        80        90       100       110       120 m312.pep AKYLSAKYGVPIVNQRISVTPIAQIAAATHADSYVSVAQTLDKAAKAIGVSFIGGFSALV |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a312 AKYLSAKYGVPIVNQRISVTPIAQIAAATHADSYVSVAQTLDKAAKAIGVSFIGGFSALV         70        80        90       100       110       120        130       140       150       160       170       180 m312.pep QKGMSPSDEVLIRSIPEAMKTTDIVCXSINIGSTRAGINMDAVKLAGETVKRTAEITPEG |||||||||||||||||||||||||| ||||||||||||||||:|||||:||||||| || a312 QKGMSPSDEVLIRSIPEAMKTTDIVCSSINIGSTRAGINMDAVRLAGETIKRTAEITLEG        130       140       150       160       170       180        190       200         210       220       230 m312.pep FGCAKIVVFCNAVEDNPFXAGAFHGSG--DAVINVGVSGPGVVKAALENSDATTLTEVAE |||||||||||||||||| ||||||||  ||||||||||||||||||||||||||||||| a312 FGCAKIVVFCNAVEDNPFMAGAFHGSGEADAVINVGVSGPGVVKAALENSDATTLTEVAE        190       200       210       220       230       240240       250       260       270         280       290 m312.pep VVKKTAFKITRVGELIGREASKMLNIPFGILDLS--PTPPVGDSVARILEEMGLSVCGTH ||||||||||||||||||||||||||||||||||  ||| |||||||||||||||||||| a312 VVKKTAFKITRVGELIGREASKMLNIPFGILDLSLAPTPAVGDSVARILEEMGLSVCGTH        250       260       270       280       290       300  300       310       320       330       340       350 m312.pep GTTAALALLNDAVKKGGMMASSAVGGLSGAFIPVSEDEGMIXAAEAGVLTLDKLEAMTAV ||||||||||||||||||||||||||||||||||||||||| |||||||||||||||||| a312 GITAALALLNDAVKKGGMMASSAVGGLSGAFIPVSEDEGMIAAAEAGVLILDKLEAMTAV        310       320       330       340       350       360  360       370       380       390       400       410 m312.pep CSVGLDMIAVPGDTPAHTISGIIADEAAIGMINSKTTAVRIIPVTGKTVGDTVEFGGLLG |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||| a312 CSVGLDMIAVPGDTPAHTISGIIADEAAIGMINSKTTAVRIIPVIGKTVGDSVEFGGLLG        370       380       390       400       410       420  420       430       440 m312.pep  YAPVMPVKEGSCEVFVNRGGRIPAPVQSMKNX |||||||||||||||||||||||||||||||| a312  YAPVMPVKEGSCEVFVNRGGRIPAPVQSMKNX        430       440       450The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1307>:

g313.seq 1 atggacgacc cgcgcaccta cggatcgggc aatcccggcg cgaccaatgt 51tttacgcagc ggcaaaaaaa aggcggccgc gctgacgctc ttgggcgatg 101 ccgccaaaggtttggttgcc gttttgcttg cacgcgtgct tcaagaaccg 151 ctcggtttat ccgacagcgcaatcgccgcc gtcgcactcg ccgcgctggt 201 cgggcatatg tggccggtgt ttttcggatttaagggcggc aaaggcgtgg 251 caacggcatt gggcgtgctt ctggcactct ctcctgcaactgccttggtc 301 tgcgcgttga tttggcttgt gatggcattc ggcttcaaag tatcctccct351 tgccgcgctg gtcgccacaa ccgccgcccc ccttgccgca ctgtttttta 401tgccgcatac ttcttggatt ttcgcaaccc tcgcaatcgc catattggtg 451 ttgctccgccataagagcaa catcctcaac ctgattaaag gcaaagaaag 501 caaaatcggc gaaaaacgct gaThis corresponds to the amino acid sequence <SEQ ID 1308; ORF 313.ng>:

g313.pep 1 MDDPRTYGSG NPGATNVLRS GKKKAAALTL LGDAAKGLVA VLLARVLQEP 51LGLSDSAIAA VALAALVGHM WPVFFGFKGG KGVATALGVL LALSPATALV 101CALIWLVMAF GFKVSSLAAL VATTAAPLAA LFFMPHTSWI FATLAIAILV 151 LLRHKSNILNLIKGKESKIG EKR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1309>:

m313.seq 1 ATGGACGACC CGCGCACCTA CGGATCGGGC AATCCGGGGG CAACCAATGT 51TTTACGCAGC GGCAAAAAAA AGGCGGCCGC GCTGACGCTC TTGGGCGATG 101 CCGCCAAAGGTTTAGTTGCC GTTTTGCTTG CACGCGTGCT TCAAGAACCG 151 CTCGGTTTAT CCGACAGCGCAATCGCGGCC GTCGCACTCG CCGCGCTGGT 201 CGGGCATATG TGGCCGGTGT TTTTCGGATTTAAAGGCGGC AAAGGCGTGG 251 CAACGGCATT GGGCGTGCTT CTGGCACTCT CTCCCGCAACTGCCTTGGTC 301 TGCGCGTTGA TTTGGCTTGT TATGGCATTC GGCTTCAAGG TGTCCTCCCT351 TGCCGCATTA ACCGCCACAA TCGCCGCACC GGTCGCCGCA TCCTTCTTTA 401TGCCGCACGT CTCGTGGGTT TGGGCGACCG TCGCCATTGC TTTGCTGGTG 451 TTGTTCCGCCACAAAAGTAA TATCGTCAAG CTGCTCGAAG GCAGAGAAAG 501 CAAAATCGGC GGCAGCCGCT GAThis corresponds to the amino acid sequence <SEQ ID 1310; ORF 313>:

m313.pep 1 MDDPRTYGSG NPGATNVLRS GKKKAAALTL LGDAAKGLVA VLLARVLQEP 51LGLSDSAIAA VALAALVGHM WPVFFGFKGG KGVATALGVL LALSPATALV 101CALIWLVMAF GFKVSSLAAL TATIAAPVAA SFFMPHVSWV WATVAIALLV 151 LFRHKSNIVKLLEGRESKIG GSR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 313 shows 90.2% identity over a 173 aa overlap with a predicted ORF(ORF 313.ng) from N. gonorrhoeae:

m313/g313         10        20        30        40        50        60m313.pep MDDPRTYGSGNPGATNVLRSGKKKAAALTLLGDAAKGLVAVLLARVLQEPLGLSDSAIAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g313MDDPRTYGSGNPGATNVLRSGKKKAAALTLLGDAAKGLVAVLLARVLQEPLGLSDSAIAA        10        20        30        40        50        60        70        80        90       100       110       120 m313.pepVALAALVGHMWPVFFGFKGGKGVATALGVLLALSPATALVCALIWLVMAFGFKVSSLAAL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g313VALAALVGHMWPVFFGFKGGKGVATALGVLLALSPATALVCALIWLVMAFGFKVSSLAAL        70        80        90       100       110       120       130       140       150       160       170 m313.pepTATIAAPVAASFFMPHVSWVWATVAIALLVLFRHKSNIVKLLEGRESKIGGSRX:|| |||:|| |||||:||::||:|||:|||:||||||::|::|:||||| :|| g313VATTAAPLAALFFMPHTSWIFATLAIAILVLLRHKSNILNLIKGKESKIGEKRX       130       140       150       160       170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1311>:

a313.seq 1 ATGGACGACC CGCGCACCTA CGGATCGGGC AATCCGGGGG CAACCAATGT 51TTTACGCAGC GGCAAAAAAA AGGCGGCCGC GCTGACGCTC TTGGGCGATG 101 CCGCCAAAGGTTTGGTTGCC GTTTTGCTTG CACGCGTGCT TCAAGAACCG 151 CTCGGTTTAT CCGACAGCGCAATCGCGGCC GTCGCACTCG CCGCGCTGGT 201 CGGGCATATG TGGCCGGTGT TTTTCGGATTTAAAGGCGGC AAAGGCGTGG 251 CAACGGCATT GGGCGTGCTT CTGGCACTCT CTCCCACAACTGCCTTGGTC 301 TGCGCGTTGA TTTGGCTTGT GATGGCATTC GGCTTCAAGG TGTCCTCCCT351 TGCCGCATTA ACCGCCACAA TCGCCGCCCC CCTTGCCGCA CTGTTTTTTA 401TGCCGCATAC TTCTTGGATT TTCGCAACCC TCGCAATCGC CATATTGGTG 451 TTGCTCCGCCATAAGAGCAA CATCCTCAAC CTGATTAAAG GCAAAGAAAG 501 CAAAATCGGC GAAAAACGCT GAThis corresponds to the amino acid sequence <SEQ ID 1312; ORF 313.a>:

a313.pep 1 MDDPRTYGSG NPGATNVLRS GKKKAAALTL LGDAAKGLVA VLLARVLQEP 51LGLSDSAIAA VALAALVGHM WPVFFGFKGG KGVATALGVL LALSPTTALV 101CALIWLVMAF GFKVSSLAAL TATIAAPLAA LFFMPHTSWI FATLAIAILV 151 LLRHKSNILNLIKGKESKIG EKR* m313/a313 90.8% identity in 173 aa overlap        10        20        30        40        50        60 m313.pepMDDPRTYGSGNPGATNVLRSGKKKAAALTLLGDAAKGLVAVLLARVLQEPLGLSDSAIAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a313MDDPRTYGSGNPGATNVLRSGKKKAAALTLLGDAAKGLVAVLLARVLQEPLGLSDSAIAA        10        20        30        40        50        60        70        80        90       100       110       120 m313.pepVALAALVGHMWPVFFGFKGGKGVATALGVLLALSPATALVCALIWLVMAFGFKVSSLAAL|||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| a313VALAALVGHMWPVFFGFKGGKGVATALGVLLALSPTTALVCALIWLVMAFGFKVSSLAAL        70        80        90       100       110       120       130       140       150       160       170 m313.pepTATIAAPVAASFFMPHVSWVWATVAIALLVLFRHKSNIVKLLEGRESKIGGSRX|||||||:|| |||||:||::||:|||:|||:||||||::|::|:||||| :|| a313TATIAAPLAALFFMPHTSWIFATLAIAILVLLRHKSNILNLIKGKESKIGEKRX       130       140       150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1313>:

g401.seq 1 atgaaattac aacaattggc tgaagaaaaa atcggcgttc tgattgtgtt 51cacgctgctt gtagtcagtg tcggtctgtt gattgaagtt gtgcccttgg 101 cctttaccaaggcggcaaca cagccggcgc cgggcgtgaa gccttacaat 151 gccctgcagg ttgccggacgcgatatttac atccgtgagg gctgttacaa 201 ctgccactct caaatgattc gtccgttccgtgcggaaacc gagcgttacg 251 gtcattactc tgttgccgga gagtcggttt acgaccatccgttccaatgg 301 ggttccaaac gtaccggtcc tgatttggca cgtgtgggcg gccgctattc351 cgacgaatgg caccgcatcc acctgctgaa tccccgtgat gtcgtgcctg 401agtccaatat gccggcattc ccgtggcttg cacgcaataa agtcgatgtc 451 gatgcaaccgttgccaacat gaaggctttg cgtaaagtag gtactcctta 501 cagtgatgag gaaattgcgaaagcgcctga ggctttggca aacaaatccg 551 agctggatgc tgtagtcgcc tatctgcaaggattgggtct ggctttgaaa 601 aacgtaaggt aaThis corresponds to the amino acid sequence <SEQ ID 1314; ORF 401.ng>:

g401.pep 1 MKLQQLAEEK IGVLIVFTLL VVSVGLLIEV VPLAFTKAAT QPAPGVKPYN 51ALQVAGRDIY IREGCYNCHS QMIRPFRAET ERYGHYSVAG ESVYDHPFQW 101 GSKRTGPDLARVGGRYSDEW HRIHLLNPRD VVPESNMPAF PWLARNKVDV 151 DATVANMKAL RKVGTPYSDEEIAKAPEALA NKSELDAVVA YLQGLGLALK 201 NVR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1315>:

m401.seq 1 ATGAAATTAC AaCAATTGGC TGAAGAAAAA ATCGGCGTTC TGATTGTGTT 51CACGCTGCTT GTAGTCAGTG TCGGTCTGTT GATTGAAGTT GTGCCCTTGG 101 CCTTTACCAAGGCGGCAACA CAGCCGGCGC CGGGCGTGAA GCCTTACAAT 151 GCCCTGCAGG TTGCCGGACGCGATATTTAC ATCCGTGAGG GCTGTTACAA 201 CTGCCACTCG CAAATGATTC GTCCGTTCCGTGCGGAAACC GAGCGTTACG 251 GTCATTACTC TGTTGCCGGA GAGTCGGTTT ACGACCATCCGTTCCAATGG 301 GGTTCCAAAC GTACCGGTCC TGATTTGGCA CGTGTGGGCG GTCGCTATTC351 CGACGAATGG CACCGTATCC ACCTGCTGAA TCCCCGTGAT GTCGTGCCTG 401AGTCCAATAT GCCGGCATTC CCGTGGCTTG CACGCAATAA AGTCGATGTC 451 GATGCAACCGTTGCCAACAT GAAGGCTTTG CGTAAAGTAG GTACTCCTTA 501 CAGTGATGAG GAAATTGCGAAAGCACCTGA GGCTTTGGCA AACAAATCCG 551 AGCTGGATGC TGTAGTCGCC TATCTGCAAGGATTGGGTCT GGCTTTGAAA 601 AACGTAAGGT AAThis corresponds to the amino acid sequence <SEQ ID 1316; ORF 401>:

m401.pep 1 MKLQQLAEEK IGVLIVFTLL VVSVGLLIEV VPLAFTKAAT QPAPGVKPYN 51ALQVAGRDIY IREGCYNCHS QMIRPFRAET ERYGHYSVAG ESVYDHPFQW 101 GSKRTGPDLARVGGRYSDEW HRIHLLNPRD VVPESNMPAF PWLARNKVDV 151 DATVANMKAL RKVGTPYSDEEIAKAPEALA NKSELDAVVA YLQGLGLALK 201 NVR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 401 shows 100.0% identity over a 203 aa overlap with a predicted ORF(ORF 401.ng) from N. gonorrhoeae:

m401/g401         10        20        30        40        50        60m401.pep MKLQQLAEEKIGVLIVFTLLVVSVGLLIEVVPLAFTKAATQPAPGVKPYNALQVAGRDIY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g401MKLQQLAEEKIGVLIVFTLLVVSVGLLIEVVPLAFTKAATQPAPGVKPYNALQVAGRDIY        10        20        30        40        50        60        70        80        90       100       110       120 m401.pepIREGCYNCHSQMIRPFRAETERYGHYSVAGESVYDHPFQWGSKRTGPDLARVGGRYSDEW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g401IREGCYNCHSQMIRPFRAETERYGHYSVAGESVYDHPFQWGSKRTGPDLARVGGRYSDEW        70        80        90       100       110       120       130       140       150       160       170       180 m401.pepHRIHLLNPRDVVPESNMPAFPWLARNKVDVDATVANMKALRKVGTPYSDEEIAKAPEALA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g401HRIHLLNPRDVVPESNMPAFPWLARNKVDVDATVANMKALRKVGTPYSDEEIAKAPEALA       130       140       150       160       170       180       190       200 m401.pep NKSELDAVVAYLQGLGLALKNVRX|||||||||||||||||||||||| g401 NKSELDAVVAYLQGLGLALKNVRX       190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1317>:

a401.seq 1 ATGAAATTAC AACAATTGGC TGAAGAAAAA ATCGGCGTTC TGATTGTGTT 51CACGCTGCTT GTAGTCAGTG TCGGTCTGTT GATTGAAGTT GTGCCCTTGG 101 CCTTTACCAAGGCGGCAACA CAGCCGGCGT CGGGCGTGAA GCCTTACAAT 151 GCCCTGCAGG TTGCCGGACGCGATATTTAC ATCCGTGAGG GCTGTTACAA 201 CTGCCACTCG CAAATGATTC GTCCGTTCCGTGCGGAAACC GAGCGTTACG 251 GTCATTACTC TGTTGCCGGA GAGTCGGTTT ACGACCATCCGTTCCAATGG 301 GGTTCCAAAC GTACCGGTCC TGATTTGGCA CGTGTGGGCG GTCGCTATTC351 CGACGAATGG CACCGTATCC ACCTGCTGAA TCCCCGTGAT GTCGTGCCTG 401AGTCCAATAT GCCGGCATTC CCGTGGCTTG CACGCAATAA AGTCGATGTC 451 GATGCAACCGTTGCCAACAT GAAGGCTTTG CGTAAAGTAG GTACTCCTTA 501 CAGTGATGAG GAAATTGCGAAAGCGCCTGA GGCTTTGGCA AACAAATCCG 551 AGCTGGATGC TGTAGTCGCC TATCTGCAAGGATTGGGTCT GGCTTTGAAA 601 AACGTAAGGT AAThis corresponds to the amino acid sequence <SEQ ID 1318; ORF 401.a>:

a401.pep 1 MKLQQLAEEK IGVLIVFTLL VVSVGLLIEV VPLAFTKAAT QPASGVKPYN 51ALQVAGRDIY IREGCYNCHS QMIRPFRAET ERYGHYSVAG ESVYDHPFQW 101 GSKRTGPDLARVGGRYSDEW HRIHLLNPRD VVPESNMPAF PWLARNKVDV 151 DATVANMKAL RKVGTPYSDEEIAKAPEALA NKSELDAVVA YLQGLGLALK 201 NVR* m401/a401 99.5% identity in203 aa overlap        10        20        30        40        50        60 m401.pepMKLQQLAEEKIGVLIVFTLLVVSVGLLIEVVPLAFTKAATQPAPGVKPYNALQVAGRDIY||||||||||||||||||||||||||||||||||||||||||| |||||||||||||||| a401MKLQQLAEEKIGVLIVFTLLVVSVGLLIEVVPLAFTKAATQPASGVKPYNALQVAGRDIY        10        20        30        40        50        60        70        80        90       100       110       120 m401.pepIREGCYNCHSQMIRPFRAETERYGHYSVAGESVYDHPFQWGSKRTGPDLARVGGRYSDEW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a401IREGCYNCHSQMIRPFRAETERYGHYSVAGESVYDHPFQWGSKRTGPDLARVGGRYSDEW        70        80        90       100       110       120       130       140       150       160       170       180 m401.pepHRIHLLNPRDVVPESNMPAFPWLARNKVDVDATVANMKALRKVGTPYSDEEIAKAPEALA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a401HRIHLLNPRDVVPESNMPAFPWLARNKVDVDATVANMKALRKVGTPYSDEEIAKAPEALA       130       140       150       160       170       180       190       200 m401.pep NKSELDAVVAYLQGLGLALKNVRX|||||||||||||||||||||||| a401 NKSELDAVVAYLQGLGLALKNVRX       190       200The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1319>:

g402.seq 1 ATGGATATGG TGAACACTAA Accgaatact agtgtgatta atatgctttc 51tttccttacc ggatTATTGA GCTTGGGTat agaagtCtTg tGGGTAAGGA 101 TGttttcgTTCGCagcAcag tccgtgcctc aggCATTTTC atttattctt 151 gcctGttttc tgACCGgtatcgccgtcggc gCgTATTTTG GCAAACGGAT 201 TTGCCGCAGC CGCTTTGTTG ATATTCCctTTATCGGGCAG TgcttcttgT 251 GGGCGGGTAT TgccgaTttt ttgatTTTGG GTGCTGCGTGGTTGTTGACG 301 GGTTTTTccg gtttcGTCCA CCACGCCGGT AtttTCATTA CCCTgtctgc351 CGtcGTCAGG GGGTTGATTT TCCCACTTGT ACACCATgtg GGTACGGATG 401GCAACAAATC CGGACGACAG GTTTCCAATG TTTATTTCGC CAACGTTGCC 451 GGCAGTGCATTGGGTCCGGT CCTTATCGGC TTTGTGATAC TTGATttgtt 501 gTCCACCCAA CAGATTtacctgctcatCTG TTTGATTTCT GCTGCtgtcc 551 cTTTGTTTTg tacaCTGtTC CAAAAAAGTCTCCGACTGAA TGCAGTGTCG 601 GTAGCAGTTT CCCTAATGTT CGGCATCCTC ATGTTCCTACTGCCGGATTC 651 TGTCTTTCAA AATATTGCTG GCCGTCCGGA TAGGTTGATT GAAAACAAAC701 ACGGCATTGT TGCGGTTTAC CATAGAGATG GTGATAAGGT TGTTTATGGG 751GCGAATGTAT ACGACGGCGC ATACAATACC GATATATTCA ATAGTGTCAA 801 CGGCATCGAACGTGCCTATC TGCTACCCTC CCTGAAGTCC GGCATACGCC 851 GCATTTTCGT CGTTGGATTGAGTACAGGTT CGTGGGCGCG CGTCTTGTCT 901 GCCATTCCGG AAATGCAGTC GATGATCGTTGCGGAAATCA ATCCGGCATA 951 CCGTAGCCTT ATCGCGGAcg agccgcAAAT CGCACCGCTTTTGCAGGACA 1001 AACGTGTTGA AATTGTATTG GATGACGGTA GGAAATGGCT GCGTCGCCAT1051 CCTGATGAAA AATTCGACCT GATTTTGATG AATTCGACTT GGTACTGGCG 1101TGCCTATTCC ACTAACCTGT TGAGTGCGGA ATTTTTAAAA CAGGTGCAAA 1151 GCCACCTTACCCCGGATGGT ATTGTAATGT TTAATACCAC GCACAGCCCG 1201 CATgctTTTG CTACCGCCGTACACAGTATT CCCTATGCAT ACCGCTACGG 1251 GCATATGGTA GTCGGCTCGG CAACCCCGGTAGTTTTCcct AATAAAGAAC 1301 TGCTCaagca aCGCCTTTcc cgGTTGATTT GGCCGGAAAGCGGCAGgcac 1351 gtATTTGACA GCAGCACCGT GGATGCTGCA GCACAAAAGG TTGtctctCG1401 TATGCTGATT CGGATGACGG AAcctTCGGC TGGGGCGGAA GTCATTACTG 1451ACGATAATAT GATTGTAGAA TACAAATACG GCAGAGGGAT TTAAThis corresponds to the amino acid sequence <SEQ ID 1320; ORF 402.ng>:

g402.pep 1 MDMVNTKPNT SVINMLSFLT GLLSLGIEVL WVRMFSFAAQ SVPQAFSFIL 51ACFLTGIAVG AYFGKRICRS RFVDIPFIGQ CFLWAGIADF LILGAAWLLT 101 GFSGFVHHAGIFITLSAVVR GLIFPLVHHV GTDGNKSGRQ VSNVYFANVA 151 GSALGPVLIG FVILDLLSTQQIYLLICLIS AAVPLFCTLF QKSLRLNAVS 201 VAVSLMFGIL MFLLPDSVFQ NIAGRPDRLIENKHGIVAVY HRDGDKVVYG 251 ANVYDGAYNT DIFNSVNGIE RAYLLPSLKS GIRRIFVVGLSTGSWARVLS 301 AIPEMQSMIV AEINPAYRSL IADEPQIAPL LQDKRVEIVL DDGRKWLRRH351 PDEKFDLILM NSTWYWRAYS TNLLSAEFLK QVQSHLTPDG IVMFNTTHSP 401HAFATAVHSI PYAYRYGHMV VGSATPVVFP NKELLKQRLS RLIWPESGRH 451 VFDSSTVDAAAQKVVSRMLI RMTEPSAGAE VITDDNMIVE YKYGRGI*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1321>:

m402.seq 1 ATGGATATAG TGAACACTAA ACCGAATACT AGTTTGATTT ATATGCnTTC 51TTTCCTTAGC GGCTTATTGA GCTTGGGTAT AGAAGTCTTG TGGGTGAGGA 101 TGTTTTCGTTCGCAGCACAG TCCGTGCCTC AGGCATTTTC ATTTACCCTT 151 GCCTGTTTTC TGACCGGTATCGCCGTCGGC GCGTATTTTG GCAAACGGAT 201 TTGCCGCAGC CGCTTTGTTG ATATTCCCTTTATCGGGCAG TGCTTCTTGT 251 GGGCGGGTAT TGCCGACTTT TTGATTTTGG GTGCTGCGTGGTTGTTGACG 301 GGTTTTTCCG GCTTCGTCCA CCACGCCGGT ATCTTCATTA CCCTGTCTGC351 CGTCGTCAsA sGGTTGATTT TCCCGCTCGT ACACCATGTG GGTACGGATG 401GCAACAAATC CGGACGACAG GTTTCCAATG TTTATTTCGC CAmCGTTGCC 451 GGCAGTGCATTGGGTCCGGT CCTTATCGGC TTTGTGATAC TTGATTTCTT 501 GTCCACCCAA CAGATTTACCTGCTCATCTG TwTGATTTCT GCTGCTGTCC 551 CTTTGTTTTG TACACTGTTC CAAAAAAGTCTCCGACTGAA TGCAGTGTCG 601 GTAGCAGTTT CCCTAATGTT CGGCATCCTC ATGTTCyTACTGCCGGATTC 651 TGTCTTTCAA AATATTGCTG ACCGTCCGGA TAgGCTGATT GAAAACAAAC701 ACGGCATTGT TGCGGTTTAC CATAGAGATG GTGATAAGGT TGTTTATGGG 751GCGAATGTAT ACGACGGCGC ATACAATACC GATGTATTCA ATAGTGTCAA 801 CGGCATCGAACGTGCCTATC TGCTACCCTC CCTGAAGTCT GGCATACGCC 851 GCATTTTCGT CGTTGGACTGAGTACAGGTT CGTGGGCGCG CGTCTTGTCT 901 GCCATTCCGG AAATGCAGTC GATGATCGTTGCGGAAATCA ATCCGGCATA 951 CCGTAGCCTT ATCGCGGACG AGCCGCAAAT CGCCCCGCTTTTGCAGGACA 1001 AACGTGTTGA AATTGTATTG GATGACGGTA GGAAATGGCT GCGTCGCCAT1051 CCTGATGAAA AATTCGACCT GATTTTGATG AATACGACTT GGTACTGGCG 1101TGCCTATTCC ACCAACCTGT TGAGTGCGGA ATTTTTAAAA CAGGTGCAAA 1151 GCCACCTTACCCCGGATGGT ATTGTAATGT TTAATACCAC GCACAGCCCG 1201 CATGCTTTTG CTACCGCCGTACACAGTATT CCCTATGCAT ACCGCTATGG 1251 GCATATGGTA GTCGGCTCGG CAACCCCGGTAGTTTTCCCT AATAAAGAAC 1301 TGCTCAAGCA ACGTCTCTCC CGGTTGATTT GGCCGGAAAGCGGCAGGCAC 1351 GTATTTGACA GCAGCACCGT GGATGCTGCA GCACAAAAGG TTGTCTCTCG1401 TATGCTGATT CAGATGACGG aAcCTTCGGC TGGGGCGGAA GTTATTACCG 1451ACGATAATAT GATTGTAGAA TACAAATACG GCAGAGGGAT TTAAThis corresponds to the amino acid sequence <SEQ ID 1322; ORF 402>:

m402.pep 1 MDIVNTKPNT SLIYMXSFLS GLLSLGIEVL WVRMFSFAAQ SVPQAFSFTL 51ACFLTGIAVG AYFGKRICRS RFVDIPFIGQ CFLWAGIADF LILGAAWLLT 101 GFSGFVHHAGIFITLSAVVX XLIFPLVHHV GTDGNKSGRQ VSNVYFAXVA 151 GSALGPVLIG FVILDFLSTQQIYLLICXIS AAVPLFCTLF QKSLRLNAVS 201 VAVSLMFGIL MFLLPDSVFQ NIADRPDRLIENKHGIVAVY HRDGDKVVYG 251 ANVYDGAYNT DVFNSVNGIE RAYLLPSLKS GIRRIFVVGLSTGSWARVLS 301 AIPEMQSMIV AEINPAYRSL IADEPQIAPL LQDKRVEIVL DDGRKWLRRH351 PDEKFDLILM NTTWYWRAYS TNLLSAEFLK QVQSHLTPDG IVMFNTTHSP 401HAFATAVHSI PYAYRYGHMV VGSATPVVFP NKELLKQRLS RLIWPESGRH 451 VFDSSTVDAAAQKVVSRMLI QMTEPSAGAE VITDDNMIVE YKYGRGI*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 402 shows 97.0% identity over a 497 aa overlap with a predicted ORF(ORF 402.ng) from N. gonorrhoeae:

m402/g402         10        20        30        40        50        60m402.pep MDIVNTKPNTSLIYMXSFLSGLLSLGIEVLWVRMFSFAAQSVPQAFSFTLACFLIGIAVG||:||||||||:| | |||:|||||||||||||||||||||||||||| ||||||||||| g402MDMVNTKPNTSVINMLSFLTGLLSLGIEVLWVRMFSFAAQSVPQAFSFILACFLTGIAVG        10        20        30        40        50        60        70        80        90      100       110        120 m402.pepAYFGKRICRSRFVDIPFIGQCFLWAGIADFLILGAAWLLTGFSGFVHHAGIFITLSAVVX|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g402AYFGKRICRSRFVDIPFIGQCFLWAGIADFLILGAAWLLTGFSGFVHHAGIFITLSAVVR        70        80        90      100       110        120       130       140       150       160       170       180 m402.pepXLIFPLVHHVGTDGNKSGRQVSNVYFAXVAGSALGPVLIGFVILDFLSTQQIYLLICXIS |||||||||||||||||||||||||| |||||||||||||||||:||||||||||| || g402GLIFPLVHHVGTDGNKSGRQVSNVYFANVAGSALGPVLIGFVILDLLSTQQIYLLICLIS       130       140       150       160       170       180       190       200       210       220       230       240 m402.pepAAVPLFCTLFQKSLRLNAVSVAVSLMFGILMFLLPDSVFQNIADRPDRLIENKHGIVAVY||||||||||||||||||||||||||||||||||||||||||| |||||||||||||||| g402AAVPLFCTLFQKSLRLNAVSVAVSLMFGILMFLLPDSVFQNIAGRPDRLIENKHGIVAVY       190       200       210       220       230       240       250       260       270       280       290       300 m402.pepHRDGDKVVYGANVYDGAYNTDVFNSVNGIERAYLLPSLKSGIRRIFVVGLSTGSWARVLS|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| g402HRDGDKVVYGANVYDGAYNTDIFNSVNGIERAYLLPSLKSGIRRIFVVGLSTGSWARVLS       250       260       270       280       290       300       310       320       330       340       350       360 m402.pepAIPEMQSMIVAEINPAYRSLIADEPQIAPLLQDKRVEIVLDDGRKWLRRHPDEKFDLILM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g402AIPEMQSMIVAEINPAYRSLIADEPQIAPLLQDKRVEIVLDDGRKWLRRHPDEKFDLILM       310       320       330       340       350       360       370       380       390       400       410       420 m402.pepNTTWYWRAYSTNLLSAEFLKQVQSHLTPDGIVMFNTTHSPHAFATAVHSIPYAYRYGHMV|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g402NSTWYWRAYSTNLLSAEFLKQVQSHLTPDGIVMFNTTHSPHAFATAVHSIPYAYRYGHMV       370       380       390       400       410       420       430       440       450       460       470       480 m402.pepVGSATPVVFPNKELLKQRLSRLIWPESGRHVFDSSTVDAAAQKVVSRMLIQMTEPSAGAE||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| g402VGSATPVVFPNKELLKQRLSRLIWPESGRHVFDSSTVDAAAQKVVSRMLIRMTEPSAGAE       430       440       450       460       470       480        490m402.pep VITDDNMIVEYKYGRGIX ||||||||||||||||| g402 VITDDNMIVEYKYGRGI       490The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1323>:

a402.seq 1 ATGGATATAG TGAACACTAA ACCGAATACT AGTTTGATTT ATATGCTTTC 51TTTCCTTAGC GGCTTATTGA GCTTGGGTAT AGAAGTCTTG TGGGTAAGGA 101 TGTTTTCGTTCGCAGCACAG TCCGTGCCTC AGGCATTTTC ATTTACTCTT 151 GCCTGTTTTC TGACCGGTATCGCCGTCGGC GCGTATTTTG GCAAACGGAT 201 TTGCCGCAGC CGCTTTGTTG ATATTCCCTTTATCGGGCAG TGCTTCTTGT 251 GGGCGGGTAT TGCCGACTTT TTGATTTTGG GTGCTGCGTGGTTGTTGACG 301 GGTTTTTCCG GCTTCGTCCA CCACGCCGGT ATCTTCATTA CCCTGTCTGC351 CGTCGTCAGA GGGTTGATTT TCCCGCTCGT ACACCATGTG GGTACGGATG 401GCAACAAATC CGGACGACAG GTTTCCAATG TTTATTTCGC CAACGTTGCC 451 GGCAGTGCATTGGGTCCGGT CCTTATCGGC TTTGTGATAC TTGATTTCTT 501 GTCCACCCAA CAGATTTACCTGCTCATCTG TTTGATTTCT GCTGCTGTCC 551 CTTTGTTTTG TACACTGTTC CAAAAAAGTCTCCGACTGAA TGCAGTGTCG 601 GTAGCAGTTT CCCTAATGTT CGGCATCCTC ATGTTCCTACTGCCGGATTC 651 TGTCTTTCAA AATATTGCTG ACCGTCCGGA TAGGCTGATT GAAAACAAAC701 ACGGCATTGT TGCGGTTTAC CATAGAGATG GTGATAAGGT TGTTTATGGG 751GCGAATGTAT ACGACGGCGC ATACAATACC GATGTATTCA ATAGTGTCAA 801 CGGCATCGAACGTGCCTATC TGCTACCCTC CCTGAAGTCT GGCATACGCC 851 GCATTTTCGT CGTTGGATTGAGTACAGGTT CGTGGGCGCG CGTCTTGTCT 901 GCCATTCCGG AAATGCAGTC GATGATCGTTGCGGAAATCA ATCCGGCATA 951 CCGTAGCCTT ATCGCGGACG AGCCGCAAAT CGCCCCGCTTTTGCAGGACA 1001 AACGTGTTGA AATTGTATTG GATGACGGTA GGAAATGGCT GCGTCGCCAT1051 CCTGATGAAA AATTCGACCT GATTTTGATG AATACGACTT GGTACTGGCG 1101TGCCTATTCC ACCAACCTGT TGAGTGCGGA ATTTTTAAAA CAGGTGCAAA 1151 GCCACCTTACCCCGGATGGT ATTGTAATGT TTAATACCAC GCACAGCCCG 1201 CATGCTTTTG CTACCGCCGTACACAGTATT CCCTATGCAT ACCGCTATGG 1251 GCATATGGTA GTCGGCTCGG CAACCCCGGTAGTTTTCCCT AATAAAGAAC 1301 TGCTCAAGCA ACGTCTCTCC CGGTTGATTT GGCCGGAAAGCGGCAGGCAC 1351 GTATTTGACA GCAGCACCGT GGATGCTGCA GCACAAAAGG TTGTCTCTCG1401 TATGCTGATT CAGATGACGG AACCTTCGGC TGGTGCGGAA GTCATTACCG 1451ACGATAATAT GATTGTAGAA TACAAATACG GCAGAGGGAT TTAAThis corresponds to the amino acid sequence <SEQ ID 1324; ORF 402.a>:

a402.pep 1 MDIVNTKPNT SLIYMLSFLS GLLSLGIEVL WVRMFSFAAQ SVPQAFSFTL 51ACFLTGIAVG AYFGKRICRS RFVDIPFIGQ CFLWAGIADF LILGAAWLLT 101 GFSGFVHHAGIFITLSAVVR GLIFPLVHHV GTDGNKSGRQ VSNVYFANVA 151 GSALGPVLIG FVILDFLSTQQIYLLICLIS AAVPLFCTLF QKSLRLNAVS 201 VAVSLMFGIL MFLLPDSVFQ NIADRPDRLIENKHGIVAVY HRDGDKVVYG 251 ANVYDGAYNT DVFNSVNGIE RAYLLPSLKS GIRRIFVVGLSTGSWARVLS 301 AIPEMQSMIV AEINPAYRSL IADEPQIAPL LQDKRVEIVL DDGRKWLRRH351 PDEKFDLILM NTTWYWRAYS TNLLSAEFLK QVQSHLTPDG IVMFNTTHSP 401HAFATAVHSI PYAYRYGHMV VGSATPVVFP NKELLKQRLS RLIWPESGRH 451 VFDSSTVDAAAQKVVSRMLI QMTEPSAGAE VITDDNMIVE YKYGRGI* m402/a402 99.0% identity in497 aa overlap        10        20        30        40        50        60 m402.pepMDIVNTKPNTSLIYMXSFLSGLLSLGIEVLWVRMFSFAAQSVPQAFSFTLACFLTGIAVG||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| a402MDIVNTKPNTSLIYMLSFLSGLLSLGIEVLWVRMFSFAAQSVPQAFSFTLACFLTGIAVG        10        20        30        40        50        60        70        80        90       100       110       120 m402.pepAYFGKRICRSRFVDIPFIGQCFLWAGIADFLILGAAWLLTGFSGFVHHAGIFITLSAVVX||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a402AYFGKRICRSRFVDIPFIGQCFLWAGIADFLILGAAWLLTGFSGFVHHAGIFITLSAVVR        70        80        90       100       110       120       130       140       150       160       170       180 m402.pepXLIFPLVHHVGTDGNKSGRQVSNVYFAXVAGSALGPVLIGFVILDFLSTQQIYLLICXIS |||||||||||||||||||||||||| ||||||||||||||||||||||||||||| || a402GLIFPLVHHVGTDGNKSGRQVSNVYFANVAGSALGPVLIGFVILDFLSTQQIYLLICLIS       130       140       150       160       170       180       190       200       210       220       230       240 m402.pepAAVPLFCTLFQKSLRLNAVSVAVSLMFGILMFLLPDSVFQNIADRPDRLIENKHGIVAVY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a402AAVPLFCTLFQKSLRLNAVSVAVSLMFGILMFLLPDSVFQNIADRPDRLIENKHGIVAVY       190       200       210       220       230       240       250       260       270       280       290       300 m402.pepHRDGDKVVYGANVYDGAYNTDVFNSVNGIERAYLLPSLKSGIRRIFVVGLSTGSWARVLS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a402HRDGDKVVYGANVYDGAYNTDVFNSVNGIERAYLLPSLKSGIRRIFVVGLSTGSWARVLS       250       260       270       280       290       300       310       320       330       340       350       360 m402.pepAIPEMQSMIVAEINPAYRSLIADEPQIAPLLQDKRVEIVLDDGRKWLRRHPDEKFDLILM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a402AIPEMQSMIVAEINPAYRSLIADEPQIAPLLQDKRVEIVLDDGRKWLRRHPDEKFDLILM       310       320       330       340       350       360       370       380       390       400       410       420 m402.pepNTTWYWRAYSTNLLSAEFLKQVQSHLTPDGIVMFNTTHSPHAFATAVHSIPYAYRYGHMV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a402NTTWYWRAYSTNLLSAEFLKQVQSHLTPDGIVMFNTTHSPHAFATAVHSIPYAYRYGHMV       370       380       390       400       410       420       430       440       450       460       470       480 m402.pepVGSATPVVFPNKELLKQRLSRLIWPESGRHVFDSSTVDAAAQKVVSRMLIQMTEPSAGAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a402VGSATPVVFPNKELLKQRLSRLIWPESGRHVFDSSTVDAAAQKVVSRMLIQMTEPSAGAE       430       440       450       460       470       480        490m402.pep VITDDNMIVEYKYGRGIX |||||||||||||||||| a402 VITDDNMIVEYKYGRGIX       490The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1325>:

g406.seq 1 ATGCGGGCAC GGCTGCTGAT ACCTATTCTT TTTTCAGTTT TTATTTTATC 51CGCCTGCGGG ACACTGACAG GTATTCCATC GCATGGCGGA GGCAAACGCT 101 TCGCGGTCGAACAAGAACTT GTGGCCGCTT CTGCCAGAGC TGCCGTTAAA 151 GACATGGATT TACAGGCATTACACGGACGA AAAGTTGCAT TGTACATTGC 201 AACTATGGGC GACCAAGGTT CAGGCAGTTTGACAGGGGGT CGCTACTCCA 251 TTGATGCACT GATTCGCGGC GAATACATAA ACAGCCCTGCCGTCCGCACC 301 GATTACACCT ATCCGCGTTA CGAAACCACC GCTGAAACAA CATCAGGCGG351 TTTGACGGGT TTAACCACTT CTTTATCTAC ACTTAATGCC CCTGCACTCT 401CGCGCACCCA ATCAGACGGT AGCGGAAGTA GGAGCAGTCT GGGCTTAAAT 451 ATTGGCGGGATGGGGGATTA TCGAAATGAA ACCTTGACGA CCAACCCGCG 501 CGACACTGCC TTTCTTTCCCACTTGGTGCA GACCGTATTT TTCCTGCGCG 551 GCATAGACGT TGTTTCTCCT GCCAATGCCGATACAGATGT GTTTATTAAC 601 ATCGACGTAT TCGGAACGAT ACGCAACAGA ACCGAAATGCACCTATACAA 651 TGCCGAAACA CTGAAAGCCC AAACAAAACT GGAATATTTC GCAGTAGACA701 GAACCAATAA AAAATTGCTC ATCAAACCCA AAACCAATGC GTTTGAAGCT 751GCCTATAAAG AAAATTACGC ATTGTGGATG GGGCCGTATA AAGTAAGCAA 801 AGGAATCAAACCGACGGAAG GATTGATGGT CGATTTCTCC GATATCCAAC 851 CATACGGCAA TCATACGGGTAACTCCGCCC CATCCGTAGA GGCTGATAAC 901 AGTCATGAGG GGTATGGATA CAGCGATGAAGCAGTGCGAC AACATAGACA 951 AGGGCAACCT TGAThis corresponds to the amino acid sequence <SEQ ID 1326; ORF 406>:

g406.pep 1 MRARLLIPIL FSVFILSACG TLTGIPSHGG GKRFAVEQEL VAASARAAVK 51DMDLQALHGR KVALYIATMG DQGSGSLTGG RYSIDALIRG EYINSPAVRT 101 DYTYPRYETTAETTSGGLTG LTTSLSTLNA PALSRTQSDG SGSRSSLGLN 151 IGGMGDYRNE TLTTNPRDTAFLSHLVQTVF FLRGIDVVSP ANADTDVFIN 201 IDVFGTIRNR TEMHLYNAET LKAQTKLEYFAVDRTNKKLL IKPKTNAFEA 251 AYKENYALWM GPYKVSKGIK PTEGLMVDFS DIQPYGNHTGNSAPSVEADN 301 SHEGYGYSDE AVRQHRQGQP *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1327>:

m406.seq 1 ATGCAAGCAC GGCTGCTGAT ACCTATTCTT TTTTCAGTTT TTATTTTATC 51CGCCTGCGGG ACACTGACAG GTATTCCATC GCATGGCGGA GGTAAACGCT 101 TTGCGGTCGAACAAGAACTT GTGGCCGCTT CTGCCAGAGC TGCCGTTAAA 151 GACATGGATT TACAGGCATTACACGGACGA AAAGTTGCAT TGTACATTGC 201 CACTATGGGC GACCAAGGTT CAGGCAGTTTGACAGGGGGT CGCTACTCCA 251 TTGATGCACT GATTCGTGGC GAATACATAA ACAGCCCTGCCGTCCGTACC 301 GATTACACCT ATCCACGTTA CGAAACCACC GCTGAAACAA CATCAGGCGG351 TTTGACAGGT TTAACCACTT CTTTATCTAC ACTTAATGCC CCTGCACTCT 401CTCGCACCCA ATCAGACGGT AGCGGAAGTA AAAGCAGTCT GGGCTTAAAT 451 ATTGGCGGGATGGGGGATTA TCGAAATGAA ACCTTGACGA CTAACCCGCG 501 CGACACTGCC TTTCTTTCCCACTTGGTACA GACCGTATTT TTCCTGCGCG 551 GCATAGACGT TGTTTCTCCT GCCAATGCCGATACAGATGT GTTTATTAAC 601 ATCGACGTAT TCGGAACGAT ACGCAACAGA ACCGAAATGCACCTATACAA 651 TGCCGAAACA CTGAAAGCCC AAACAAAACT GGAATATTTC GCAGTAGACA701 GAACCAATAA AAAATTGCTC ATCAAACCAA AAACCAATGC GTTTGAAGCT 751GCCTATAAAG AAAATTACGC ATTGTGGATG GGGCCGTATA AAGTAAGCAA 801 AGGAATTAAACCGACGGAAG GATTAATGGT CGATTTCTCC GATATCCGAC 851 CATACGGCAA TCATACGGGTAACTCCGCCC CATCCGTAGA GGCTGATAAC 901 AGTCATGAGG GGTATGGATA CAGCGATGAAGTAGTGCGAC AACATAGACA 951 AGGACAACCT TGAThis corresponds to the amino acid sequence <SEQ ID 1328; ORF 406>:

m406.pep 1 MQARLLIPIL FSVFILSACG TLTGIPSHGG GKRFAVEQEL VAASARAAVK 51DMDLQALHGR KVALYIATMG DQGSGSLTGG RYSIDALIRG EYINSPAVRT 101 DYTYPRYETTAETTSGGLTG LTTSLSTLNA PALSRTQSDG SGSKSSLGLN 151 IGGMGDYRNE TLTTNPRDTAFLSHLVQTVF FLRGIDVVSP ANADTDVFIN 201 IDVFGTIRNR TEMHLYNAET LKAQTKLEYFAVDRTNKKLL IKPKTNAFEA 251 AYKENYALWM GPYKVSKGIK PTEGLMVDFS DIRPYGNHTGNSAPSVEADN 301 SHEGYGYSDE VVRQHRQGQP *Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 406 shows 98.8% identity over a 320 aa overlap with a predicted ORF(ORF406.a) from N. gonorrhoeae:

g406/m406         10        20        30        40        50        60g406.pep MRARLLIPILFSVFILSACGTLTGIPSHGGGKRFAVEQELVAASARAAVKDMDLQALHGR|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m406MQARLLIPILFSVFILSACGTLTGIPSHGGGKRFAVEQELVAASARAAVKDMDLQALHGR        10        20        30        40        50        60        70        80        90       100       110       120 g406.pepKVALYIATMGDQGSGSLTGGRYSIDALIRGEYINSPAVRTDYTYPRYETTAETTSGGLTG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m406KVALYIATMGDQGSGSLTGGRYSIDALIRGEYINSPAVRTDYTYPRYETTAETTSGGLTG        70        80        90       100       110       120       130       140       150       160       170       180 g406.pepLTTSLSTLNAPALSRTQSDGSGSRSSLGLNIGGMGDYRNETLTTNPRDTAFLSHLVQTVF|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| m406LTTSLSTLNAPALSRTQSDGSGSKSSLGLNIGGMGDYRNETLTTNPRDTAFLSHLVQTVF       130       140       150       160       170       180       190       200       210       220       230       240 g406.pepFLRGIDVVSPANADTDVFINIDVFGTIRNRTEMHLYNAETLKAQTKLEYFAVDRTNKKLL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m406FLRGIDVVSPANADTDVFINIDVFGTIRNRTEMHLYNAETLKAQTKLEYFAVDRTNKKLL       190       200       210       220       230       240       250       260       270       280       290       300 g406.pepIKPKTNAFEAAYKENYALWMGPYKVSKGIKPTEGLMVDFSDIQPYGNHTGNSAPSVEADN||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||| m406IKPKTNAFEAAYKENYALWMGPYKVSKGIKPTEGLMVDFSDIRPYGNHTGNSAPSVEADN       250       260       270       280       290       300       310       320 g406.pep SHEGYGYSDEAVRQHRQGQPX||||||||||:|||||||||| m406 SHEGYGYSDEVVRQHRQGQPX        310       320The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1329>:

a406.seq 1 ATGCAAGCAC GGCTGCTGAT ACCTATTCTT TTTTCAGTTT TTATTTTATC 51CGCCTGCGGG ACACTGACAG GTATTCCATC GCATGGCGGA GGTAAACGCT 101 TCGCGGTCGAACAAGAACTT GTGGCCGCTT CTGCCAGAGC TGCCGTTAAA 151 GACATGGATT TACAGGCATTACACGGACGA AAAGTTGCAT TGTACATTGC 201 AACTATGGGC GACCAAGGTT CAGGCAGTTTGACAGGGGGT CGCTACTCCA 251 TTGATGCACT GATTCGTGGC GAATACATAA ACAGCCCTGCCGTCCGTACC 301 GATTACACCT ATCCACGTTA CGAAACCACC GCTGAAACAA CATCAGGCGG351 TTTGACAGGT TTAACCACTT CTTTATCTAC ACTTAATGCC CCTGCACTCT 401CGCGCACCCA ATCAGACGGT AGCGGAAGTA AAAGCAGTCT GGGCTTAAAT 451 ATTGGCGGGATGGGGGATTA TCGAAATGAA ACCTTGACGA CTAACCCGCG 501 CGACACTGCC TTTCTTTCCCACTTGGTACA GACCGTATTT TTCCTGCGCG 551 GCATAGACGT TGTTTCTCCT GCCAATGCCGATACGGATGT GTTTATTAAC 601 ATCGACGTAT TCGGAACGAT ACGCAACAGA ACCGAAATGCACCTATACAA 651 TGCCGAAACA CTGAAAGCCC AAACAAAACT GGAATATTTC GCAGTAGACA701 GAACCAATAA AAAATTGCTC ATCAAACCAA AAACCAATGC GTTTGAAGCT 751GCCTATAAAG AAAATTACGC ATTGTGGATG GGACCGTATA AAGTAAGCAA 801 AGGAATTAAACCGACAGAAG GATTAATGGT CGATTTCTCC GATATCCAAC 851 CATACGGCAA TCATATGGGTAACTCTGCCC CATCCGTAGA GGCTGATAAC 901 AGTCATGAGG GGTATGGATA CAGCGATGAAGCAGTGCGAC GACATAGACA 951 AGGGCAACCT TGAThis corresponds to the amino acid sequence <SEQ ID 1330; ORF 406.a>:

a406.pep 1 MQARLLIPIL FSVFILSACG TLTGIPSHGG GKRFAVEQEL VAASARAAVK 51DMDLQALHGR KVALYIATMG DQGSGSLTGG RYSIDALIRG EYINSPAVRT 101 DYTYPRYETTAETTSGGLTG LTTSLSTLNA PALSRTQSDG SGSKSSLGLN 151 IGGMGDYRNE TLTTNPRDTAFLSHLVQTVF FLRGIDVVSP ANADTDVFIN 201 IDVFGTIRNR TEMHLYNAET LKAQTKLEYFAVDRTNKKLL IKPKTNAFEA 251 AYKENYALWM GPYKVSKGIK PTEGLMVDFS DIQPYGNHMGNSAPSVEADN 301 SHEGYGYSDE AVRRHRQGQP * m406/a406 98.8% identity in 320aa overlap         10        20        30        40        50        60m406.pep MQARLLIPILFSVFILSACGTLTGIPSHGGGKRFAVEQELVAASARAAVKDMDLQALHGR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a406MQARLLIPILFSVFILSACGTLTGIPSHGGGKRFAVEQELVAASARAAVKDMDLQALHGR        10        20        30        40        50        60        70        80        90       100       110       120 m406.pepKVALYIATMGDQGSGSLTGGRYSIDALIRGEYINSPAVRTDYTYPRYETTAETTSGGLTG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a406KVALYIATMGDQGSGSLTGGRYSIDALIRGEYINSPAVRTDYTYPRYETTAETTSGGLTG        70        80        90       100       110       120       130       140       150       160       170       180 m406.pepLTTSLSTLNAPALSRTQSDGSGSKSSLGLNIGGMGDYRNETLTTNPRDTAFLSHLVQTVF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a406LTTSLSTLNAPALSRTQSDGSGSKSSLGLNIGGMGDYRNETLTTNPRDTAFLSHLVQTVF       130       140       150       160       170       180       190       200       210       220       230       240 m406.pepFLRGIDVVSPANADTDVFINIDVFGTIRNRTEMHLYNAETLKAQTKLEYFAVDRTNKKLL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a406FLRGIDVVSPANADTDVFINIDVFGTIRNRTEMHLYNAETLKAQTKLEYFAVDRTNKKLL       190       200       210       220       230       240       250       260       270       280       290       300 m406.pepIKPKTNAFEAAYKENYALWMGPYKVSKGIKPTEGLMVDFSDIRPYGNHTGNSAPSVEADN||||||||||||||||||||||||||||||||||||||||||:||||| ||||||||||| a406IKPKTNAFEAAYKENYALWMGPYKVSKGIKPTEGLMVDFSDIQPYGNHMGNSAPSVEADN       250       260       270       280       290       300       310       320 m406.pep SHEGYGYSDEVVRQHRQGQPX||||||||||:||:||||||| a406 SHEGYGYSDEAVRRHRQGQPX        310       320The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1331>:

g501.seq 1 atggtcggac ggaccttgac cgcagatacc gacatatttg ttctgcttgc, 51ggcaggcgga gatggcaaga tgcagcatca ctttgacggc agggttgcgt 101 tcgtcaaacgattcggacac caagccgctg tctcggtcga ggccgagggt 151 cagctgggtc atgtcgttcgagccgatgga gaagccgtcg aagtattgca 201 ggaattgttc cgccaatacc gcgttgctcggcagctcgca catcataatc 251 aggcgcaggc cgtttttgcc gcgttccaag ccgttttctttcaatgcctt 301 aaccactgct tcggcttcgc ccaaagtgcg gacgaacgga atcatgattt351 cgacgttggt cagacccatt tcgtcacgaa cgcgtttcaa ggctttgcat 401tccaaggcga aacagtcttt gaagctctcg gcaacataac gcgccgcacc 451 acggaagcccaacatcgggt tttcttcatg cggttcgtat acgctgccgc 501 cgaccaggtt ggcgtattcgttggatttga agtcggacat acggacgatg 551 gttttacgcg gataaaccga tgcggcaagcgttgccacgc cttcggcgat 601 tttatcgacg tagaagtcga caggggatgc gtaaccggcgatgcggcgga 651 taatttccgc tttcagttcg tcgtcttgtt tgtcaaattc caacaaggct701 ttcgggtgga tgccgatttg gcggttgatg ataaattcca tacgcgccaa 751gccgatgcct tcgctgggca gattggcgaa gctgaatgcg agttcgggat 801 tgccgacgttcatcatgact ttgacgggtg cttttggcat attgtccaag 851 gcgacatcgg taatttgtacgtccagcagg ccggcataga taaagccggt 901 atcgccttcg gcacaggata cggtaacttcctgaccgttt tccaagagtt 951 cggtcgcatt gccgcagccg acgacggcag gaatacccagttcgcgcgcg 1001 atgatggcgg cgtggcaggt gcgtccgccg cggttggtca cgatggcgga1051 agcacgtttc atcacgggtt cccaatccgg atcggtcatg tcggtaacca 1101gtacgtcgcc ggcttcgacg gaatccatct cggaagcatc tttaatcagg 1151 cgcaccttgccctgaccgac tttttgaccg atggcacgac cttcgcacaa 1201 gacggttttt tcgccgttgatggcgtagcg gcgcaggttg cggctgcctt 1251 cttcttggga tttgacggtt tcggggcgggcttgcaggat gtagagtttg 1301 ccgtccaggc cgtcgcgtcc ccattcgata tccatcgggcggccgtagtg 1351 tttttcgatg gtcagcgcgt agtgtgccaa ctcggtgatt tcttcgtcgg1401 taatggagaa gcggttgcgg tcttcttcgg ggacttcgac gttggttacc 1451gatttgccgg cttcggcttt gtcggtgaaa atcattttga tgtgtttcga 1501 acccatggtcttgcgcagga tggcgggttt gcctgctttg agcgtgggtt 1551 tgaacacata aaattcgtccgggttgaccg cgccttgtac gacgttttcg 1601 cccagaccgt aagaggaggt aacaaagacgacttggttgt agccggattc 1651 ggtgtcgagg gtgaacatca cacctgaThis corresponds to the amino acid sequence <SEQ ID 1332; ORF 501.ng>:

g501.pep 1 MVGRTLTADT DIFVLLAAGG DGKMQHHFDG RVAFVKRFGH QAAVSVEAEG 51QLGHVVRADG EAVEVLQELF RQYRVARQLA HHNQAQAVFA AFQAVFFQCL 101 NHCFGFAQSADERNHDFDVG QTHFVTNAFQ GFAFQGETVF EALGNITRRT 151 TEAQHRVFFM RFVYAAADQVGVFVGFEVGH TDDGFTRINR CGKRCHAFGD 201 FIDVEVDRGC VTGDAADNFR FQFVVLFVKFQQGFRVDADL AVDDKFHTRQ 251 ADAFAGQIGE AECEFGIADV HHDFDGCFWH IVQGDIGNLYVQQAGIDKAG 301 IAFGTGYGNF LTVFQEFGRI AAADDGRNTQ FARDDGGVAG ASAAVGHDGG351 STFHHGFPIR IGHVGNQYVA GFDGIHLGSI FNQAHLALTD FLTDGTTFAQ 401DGFFAVDGVA AQVAAAFFLG FDGFGAGLQD VEFAVQAVAS PFDIHRAAVV 451 FFDGQRVVCQLGDFFVGNGE AVAVFFGDFD VGYRFAGFGF VGENHFDVFR 501 THGLAQDGGF ACFERGFEHIKFVRVDRALY DVFAQTVRGG NKDDLVVAGF 551 GVEGEHHT*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1333>:

m501.seq 1 atggtcggac sggccttgac cgcagatgcc gacatatttg ttctgcttgc 51ggcaggcgga gatggcaagg tgcagcatca ctttgacggc agggttgcgt 101 tcgtcaaacgattcggatac caagccgctg tcgcggtcga gaccgagggt 151 cagttgggtc atgtcgttcgagccgatgga gaagccgtcg aagtattgca 201 ggaattgttc cgccaatacc gcgttgctcggcagctcgca catcataatc 251 aggcgcaggc cgtttttgcc gcgttccaag ccgttttctttcagggcttt 301 gacaacggmt tcggcttcgc ccaaagtgcg gacgaacgga atcatgattt351 caacgttggy caaccccatt tcatcgcgga cgcgtttcaa ggctttgcat 401tccaaggcga aacagtcttt gaagttgtcg gcgacataac gcgccgcacc 451 acggaagcccaacatcgggt tttcttcatg cggttcgtat acgttgccgc 501 cgaccaggtt ggcgtattcgttggatttga agtcggacat acggacgatg 551 gttttacgcg gataaaccga tgcggccaatgtcgccacgc cttcggcgat 601 tttatcgacg tagaagtcga caggggacgc gtaaccggcgatacggcggg 651 taatttccgc ttttaattcg tcgtcttgtt tgtcaaattc caacaargct701 ttggggtgga taccgatttg gcggttgatg ataaattcca tacgcgccaa 751gccgatgcct tcgctgggca ggttggcgaa gctgaatgcg agttcgggat 801 tgccgacgttcatcatgact tttacaggtg ctttaggcat attgtctaag 851 gcgacatcgg taatctgtacgtccaacaga ccggcataga taaagccggt 901 atcgccttcg gcacaggata cggtaacttcttgaccgttt ttcagcaatt 951 cggttgcatt gccgcagccg acaacggcag gaatgcccaattcacgcgcg 1001 atgatggcgg cgtggcaggt acggccgccg cggttggtaa cgatggcaga1051 agcacgtttc atcacgggtt cccaatccgg atcggtcatg tcggtaacga 1101gtacgtcgcc ggcttcgacg gaatccatct cggaagcatc tttaatcagg 1151 cgcaccttgccctgaccgac tttctgaccg atggcgcggc cttcgcataa 1201 tacggttttg tcgccgttgatggcgaagcg gcgcaggttg cggttgccct 1251 cttcttggga ttttacggtt tcgggacgggcttgcaggat gtagagtttg 1301 ccgtccaagc cgtcgcgtcc ccattcgata tccatcgggcggccgtagtg 1351 tttttcgatg gtcagtgcgt aatgcgccaa ctcagtaatt tcttcgtcgg1401 taatggagaa gcggttgcgg tcttcctcgg ggacatcgac gttggttacg 1451gatttaccgg cttctgcttt gtcggtaaaa atcattttga tgtgttttga 1501 acccatggttttacgcagga tggcgggctt gcccgytttg agcgtgggtt 1551 tgaacacatr aaattcgtccgggttgaccg caccttgtac gacgttttcg 1601 cccagaccgt aagaggaggt aacaaagacgacytgatcgt akccggattc 1651 ggtgtcgagg gtgaacatca cacctgaThis corresponds to the amino acid sequence <SEQ ID 1334; ORF 501>:

m501.pep 1 MVGXALTADA DIFVLLAAGG DGKVQHHFDG RVAFVKRFGY QAAVAVETEG 51QLGHVVRADG EAVEVLQELF RQYRVARQLA HHNQAQAVFA AFQAVFFQGF 101 DNGFGFAQSADERNHDFNVG QPHFIADAFQ GFAFQGETVF EVVGDITRRT 151 TEAQHRVFFM RFVYVAADQVGVFVGFEVGH TDDGFTRINR CGQCRHAFGD 201 FIDVEVDRGR VTGDTAGNFR FXFVVLFVKFQQXFGVDTDL AVDDKFHTRQ 251 ADAFAGQVGE AECEFGIADV HHDFYRCFRH IVXGDIGNLYVQQTGIDKAG 301 IAFGTGYGNF LTVFQQFGCI AAADNGRNAQ FTRDDGGVAG TAAAVGNDGR351 STFHHGFPIR IGHVGNEYVA GFDGIHLGSI FNQAHLALTD FLTDGAAFAX 401YGFVAVDGEA AQVAVALFLG FYGFGTGLQD VEFAVQAVAS PFDIHRAAVV 451 FFDGQCVMRQLSNFFVGNGE AVAVFLGDID VGYGFTGFCF VGKNHFDVFX 501 THGFTQDGGL ARFERGFEHXKFVRVDRTLY DVFAQTVRGG NKDDLIVXGF 551 GVEGEHHT*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae ORF 501 shows 86.2%identity over a 558 aa overlap with a predicted ORF (ORF 501.ng) from N.gonorrhoeae:

m501/g501         10        20        30        40        50        60m501.pep MVGXALTADADIFVLLAAGGDGKVQHHFDGRVAFVKRFGYQAAVAVETEGQLGHVVRADG||| :||||:|||||||||||||:|||||||||||||||:||||:||:|||||||||||| g501MVGRTLTADTDIFVLLAAGGDGKMQHHFDGRVAFVKRFGHQAAVSVEAEGQLGHVVRADG        10        20        30        40        50        60        70        80        90       100       110       120 m501.pepEAVEVLQELFRQYRVARQLAHHNQAQAVFAAFQAVFFQGFDNGFGFAQSADERNHDFNVG|||||||||||||||||||||||||||||||||||||| ::: ||||||||||||||:|| g501EAVEVLQELFRQYRVARQLAHHNQAQAVFAAFQAVFFQCLNHCFGFAQSADERNHDFDVG        70        80        90       100       110       120       130       140       150       160       170       180 m501.pepQPHFIADAFQGFAFQGETVFEVVGDITRRTTEAQHRVFFMRFVYVAADQVGVFVGFEVGH| ||:::||||||||||||||::|:|||||||||||||||||||:||||||||||||||| g501QTHFVTNAFQGFAFQGETVFEALGNITRRTTEAQHRVFFMRFVYAAADQVGVFVGFEVGH       130       140       150       160       170       180       190       200       210       220       230       240 m501.pepTDDGFTRINRCGQCRHAFGDFIDVEVDRGRVTGDTAGNFRFXFVVLFVKFQQXFGVDTDL||||||||||||:  |||||||||||||| ||||:| |||| |||||||||| | ||:|| g501TDDGFTRINRCGKRCHAFGDFIDVEVDRGCVTGDAADNFRFQFVVLFVKFQQGFRVDADL       190       200       210       220       230       240       250       260       270       280       290       300 m501.pepAVDDKFHTRQADAFAGQVGEAECEFGIADVHHDFYRCFRHIVXGDIGNLYVQQTGIDKAG|||||||||||||||||:||||||||||||||||  || ||| ||||||||||:|||||| g501AVDDKFHTRQADAFAGQIGEAECEFGIADVHHDFDGCFWHIVQGDIGNLYVQQAGIDKAG       250       260       270       280       290       300       310       320       330       340       350       360 m501.pepIAFGTGYGNFLTVFQQFGCIAAADNGRNAQFTRDDGGVAGTAAAVGNDGRSTFHHGFPIR|||||||||||||||:|| |||||:|||:||:||||||||::||||:|| |||||||||| g501IAFGTGYGNFLTVFQEFGRIAAADDGRNTQFARDDGGVAGASAAVGHDGGSTFHHGFPIR       310       320       330       340       350       360       370       380       390       400       410       420 m501.pepIGHVGNEYVAGFDGIHLGSIFNQAHLALTDFLTDGAAFAXYGFVAVDGEAAQVAVALFLG||||||:||||||||||||||||||||||||||||::|| || |||| |||||:|:||| g501IGHVGNQYVAGFDGIHLGSIFNQAHLALTDFLTDGTTFAQDGFFAVDGVAAQVAAAFFLG       370       380       390       400       410       420       430       440       450       460       470       480 m501.pepFYGFGTGLQDVEFAVQAVASPFDIHRAAVVFFDGQCVMRQLSNFFVGNGEAVAVFLGDID| |||:||||||||||||||||||||||||||||| |: ||::||||||||||||:||:| g501FDGFGAGLQDVEFAVQAVASPFDIHRAAVVFFDGQRVVCQLGDFFVGNGEAVAVFFGDFD       430       440       450       460       470       480       490       500       510       520       530       540 m501.pepVGYGFTGFCFVGKNHFDVFXTHGFTQDGGLARFERGFEHXKFVRVDRTLYDVFAQTVRGG||| |:|| |||:|||||| |||::||||:| ||||||| |||||||:|||||||||||| g501VGYRFAGFGFVGENHFDVFRTHGLAQDGGFACFERGFEHIKFVRVDRALYDVFAQTVRGG       490       500       510       520       530       540        550m501.pep NKDDLIVXGFGVEGEHHT |||||:| |||||||||| g501 NKDDLVVAGFGVEGEHHT       550The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1335>:

a501.seq (partial) 1 ATGGTCGGAC GGGCCTTGAC CGCAGATGCC GACATATTTGTTCTGCTTGC 51 GGCAGGCGGA GATGGCAAGG TGCAGCATCA CTTTGACGGC AGGGTTGCGT 101TCGTCAAACG ATTCGGATAC CAAGCCGCTG TCGCGGTCGA GACCGAGGGT 151 CAGTTGGGTCATGTCGTTCG AGCCGATGGA GAAGCCGTCG AAGTATTGCA 201 GGAATTGTTC CGCCAATACCGCGTTGCTCG GCAGCTCGCA CATCATAATC 251 AGGCGCAGGC CGTTTTTGCC GCGTTCCAAGCCGTTTTCTT TCAGGGCTTT 301 GACAACGGCT TCGGCTTCGC CCAAAGTGCG GACGAACGGAATCATGATTT 351 CAACGTTGGT CAACCCCATT TCATCGCGGA CGCGTTTCAA GGCTTTGCAT401 TCCAAGGCGA AACAGTCTTT GAAGTTGTCG GCGACATAAC GCGCCGCACC 451ACGGAAGCCC AACATCGGGT TTTCTTCATG CGGTTCGTAT ACGTTGCCGC 501 CGACCAGGTTGGCGTATTCG TTGGATTTGA AGTCGGACAT ACGGACGATG 551 GTTTTACGCG GATAAACCGATGCGGCCAAT GTCGCCACGC CTTCGGCGAT 601 TTTATCGACG TAGAAGTCGA CAGGGGACGCGTAACCGGCG ATACGGCGGG 651 TAATTTCCGC TTTTAATTCG TCGTCTTGTT TGTCAAATTCCAACAAGGCT 701 TTGGGGTGGA TACCGATTTG GCGGTTGATG ATAAATTCCA TACGCGCCAA751 GCCGATGCCT TCGCTGGGCA GGTTGGCGAA GCTGAATGCG AGTTCGGGAT 801TGCCGACGTT CATCATGACT TTTACAGGTG CTTTAGGCAT GTTGTCCAAA 851 GCAACATCGGTAATTTGTAC GTCCAGCAGG CCGGAGTAGA TGAAGCCGGT 901 ATCGCCTTCG GCACAGGATACGGTAACTTC TTGACCGTTT TTCAGCAATT 951 CGGTTGCATT GCCGCAGCCG ACAACGGCAGGAATACCCAG TTCGCGCGCG 1001 ATGATGGCGG CGTGGCAGGT ACGTCCGCCC CTGTTGGTCACGATGGCGGA 1051 AGCGCGTTTC ATCACCGGTT CCCAATCTGG GTCGGTCATG TCGGTAACCA1101 GTACGTCGCC GGCTTCGACG GAATCCATCT CGGAAGCATC TTTAATCAGG 1151CGTACCTTGC CCTGACCGAC TTTCTGACCG ATGGCGCGGC CTTCGCACAA 1201 GACGGTTTTTTCGCCGTTGA TAGAAAAGCG GCGCAGGTTG CGGCTGCCTT 1251 CTTCCTGGGA TTTGACGGTTTCGGGACGGG CTTGCAGGAT GTAGAGTTTG 1301 CCGTCCAAGC CGTCGCGTCC CCATTCGATGTCCATCGGGC GGCCGTAGTG 1351 TTTTTCGATG GTCAGTGCGT AATGCGCCAA CTCGGTGATTTCTTCGTCGG 1401 TAATGGAGAA GCGGTTGCGG TCTTCTTCGG GGACATCGAC GTTGGTTACC1451 GATTTGCCGG CTTCTGCTTT GTCGGTAAAA ATCATTTTGA TGTGTTTTGA 1501GCCCATGGTT TTGCGCAGGA TGGCAGGTTT GCCTGCTTTC AGCGTGGGTT 1551 TGAACACATAGAATTCGTCG GGATTGACTG CGCCTTGTAC GACGTTTTCG 1601 CCCAGACCGT AGGATGAAGTGACAAAGACG ACTTGGTCGT AACCGGATTC 1651 GGTATCGAGG GTGAACATCA CThis corresponds to the amino acid sequence <SEQ ID 1336; ORF 501.a>:

a501.pep 1 MVGRALTADA DIFVLLAAGG DGKVQHHFDG RVAFVKRFGY QAAVAVETEG 51QLGHVVRADG EAVEVLQELF RQYRVARQLA HHNQAQAVFA AFQAVFFQGF 101 DNGFGFAQSADERNHDFNVG QPHFIADAFQ GFAFQGETVF EVVGDITRRT 151 TEAQHRVFFM RFVYVAADQVGVFVGFEVGH TDDGFTRINR CGQCRHAFGD 201 FIDVEVDRGR VTGDTAGNFR F*FVVLFVKFQQGFGVDTDL AVDDKFHTRQ 251 ADAFAGQVGE AECEFGIADV HHDFYRCFRH VVQSNIGNLYVQQAGVDEAG 301 IAFGTGYGNF LTVFQQFGCI AAADNGRNTQ FARDDGGVAG TSAPVGHDGG351 SAFHHRFPIW VGHVGNQYVA GFDGIHLGSI FNQAYLALTD FLTDGAAFAQ 401DGFFAVDRKA AQVAAAFFLG FDGFGTGLQD VEFAVQAVAS PFDVHRAAVV 451 FFDGQCVMRQLGDFFVGNGE AVAVFFGDID VGYRFAGFCF VGKNHFDVF* 501 AHGFAQDGRF ACFQRGFEHIEFVGIDCALY DVFAQTVG*S DKDDLVVTGF 551 GIEGEHH m501/a501 90.3% identity in557 aa overlap        10        20        30        40        50        60 m501.pepMVGXALTADADIFVLLAAGGDGKVQHHFDGRVAFVKRFGYQAAVAVETEGQLGHVVRADG||| |||||||||||||||||||||||||||||||||||||||||||||||||||||||| a501MVGRALTADADIFVLLAAGGDGKVQHHFDGRVAFVKRFGYQAAVAVETEGQLGHVVRADG        10        20        30        40        50        60        70        80        90       100       110       120 m501.pepEAVEVLQELFRQYRVARQLAHHNQAQAVFAAFQAVFFQGFDNGFGFAQSADERNHDFNVG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a501EAVEVLQELFRQYRVARQLAHHNQAQAVFAAFQAVFFQGFDNGFGFAQSADERNHDFNVG        70        80        90       100       110       120       130       140       150       160       170       180 m501.pepQPHFIADAFQGFAFQGETVFEVVGDITRRTTEAQHRVFFMRFVYVAADQVGVFVGFEVGH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a501QPHFIADAFQGFAFQGETVFEVVGDITRRTTEAQHRVFFMRFVYVAADQVGVFVGFEVGH       130       140       150       160       170       180       190       200       210       220       230       240 m501.pepTDDGFTRINRCGQCRHAFGDFIDVEVDRGRVTGDTAGNFRFXFVVLFVKFQQXFGVDTDL|||||||||||||||||||||||||||||||||||||||||||||||||||| ||||||| a501TDDGFTRINRCGQCRHAFGDFIDVEVDRGRVTGDTAGNFRFXFVVLFVKFQQGFGVDTDL       190       200       210       220       230       240       250       260       270       280       290       300 m501.pepAVDDKFHTRQADAFAGQVGEAECEFGIADVHHDFYRCFRHIVXGDIGNLYVQQTGIDKAG||||||||||||||||||||||||||||||||||||||||:| ::||||||||:|:|:|| a501AVDDKFHTRQADAFAGQVGEAECEFGIADVHHDFYRCFRHVVQSNIGNLYVQQAGVDEAG       250       260       270       280       290       300       310       320       330       340       350       360 m501.pepIAFGTGYGNFLTVFQQFGCIAAADNGRNAQFTRDDGGVAGTAAAVGNDGRSTFHHGFPIR||||||||||||||||||||||||||||:||:|||||||||:| ||:|| |:||| ||| a501IAFGTGYGNFLTVFQQFGCIAAADNGRNTQFARDDGGVAGTSAPVGHDGGSAFHHRFPIW       310       320       330       340       350       360       370       380       390       400       410       420 m501.pepIGHVGNEYVAGFDGIHLGSIFNQAHLALTDFLTDGAAFAXYGFVAVDGEAAQVAVALFLG:|||||:|||||||||||||||||:||||||||||||||  || ||| :|||||:|:||| a501VGHVGNQYVAGFDGIHLGSIFNQAYLALTDFLTDGAAFAQDGFFAVDRKAAQVAAAFFLG       370       380       390       400       410       420       430       440       450       460       470       480 m501.pepFYGFGTGLQDVEFAVQAVASPFDIHRAAVVFFDGQCVMRQLSNFFVGNGEAVAVFLGDID| |||||||||||||||||||||:|||||||||||||||||::||||||||||||:|||| a501FDGFGTGLQDVEFAVQAVASPFDVHRAAVVFFDGQCVMRQLGDFFVGNGEAVAVFFGDID       430       440       450       460       470       480       490       500       510       520       530       540 m501.pepVGYGFTGFCFVGKNHFDVFXTHGFTQDGGLARFERGFEHXKFVRVDRTLYDVFAQTVRGG||| |:||||||||||||||:|||:||| :| |:||||| :|| :| :|||||||||  : a501VGYRFAGFCFVGKNHFDVFXAHGFAQDGRFACFQRGFEHIEFVGIDCALYDVFAQTVGXS       490       500       510       520       530       540       550       559 m501.pep NKDDLIVXGFGVEGEHHTX :||||:|:|||:||||| a501DKDDLVVTGFGIEGEHH        550The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1337>:

g502.seq 1 atgatgaaac cgcacaacct gttccaattc ctcgccgttt gctccctgac 51cgtcgccgtc gcttccgcac aggcgggcgc ggtggacgcg ctcaagcaat 101 tcaacaacgatgccgacggt atcagcggca gcttcaccca aaccgtccaa 151 agcaaaaaga aaacccaaaccgcgcacggc acgttcaaaa tcctgcgccc 201 gggcctcttc aaatgggaat acactttgccctacagacag actattgtcg 251 gcgacggtca aaccgtttgg ctctacgatg ttgatttggcacaagtgacc 301 aagtcgtccc aagaccaggc catcggcggc agccccgccg ccatcctgtc351 gaacaaaacc gccctcgaaa gcagttacac gctgaaagag gacggttcgt 401ccaacggcat cgattatgtg cggggcaacg cccaaacgca acaacgccgg 451 ctaccaatacatccgcatcg gcttcaaagg cggcaacctc gccgccatgc 501 agcttaaThis corresponds to the amino acid sequence <SEQ ID 1338; ORF 502.ng>:

g502.pep 1 MMKPHNLFQF LAVCSLTVAV ASAQAGAVDA LKQFNNDADG ISGSFTQTVQ 51SKKKTQTAHG TFKILRPGLF KWEYTLPYRQ TIVGDGQTVW LYDVDLAQVT 101 KSSQDQAIGGSPAAILSNKT ALESSYTLKE DGSSNGIDYV RGNAQTQQRR 151 LPIHPHRLQR RQPRRHAA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1339>:

m502.seq 1 atgatgaaac cgcacaacct gttccaattc ctcgccgttt gctccctgac 51cgtcgccgtc gcttccgcac aggcgggcgc ggtagacgcg cttaagcaat 101 tcaacaacgatgccgacggt atcagcggca gcttcaccca amccgtccaa 151 wgcaaaaaga aaacccaaaccgcgcacggc acgttcaaaa tcctgcgacc 201 gggccttttc aaatgggaat acaccaaactt.acaggcaa accatcgtcg 251 gcgacggtca aacygtttgg ctmtacgatg tygatctggcacaagtgacc 301 aagtcgtccc aagaccaggc cataggcgsc agccccgccg ccatcctgtc351 gaacaaarcc gccctcgaaa gcagctacac gctgaaagag gacggttcgt 401ccaacggcat cgattatgtg ggcaacgccc aaacgcaaca acgccggcta 451 ccaatacatccgcatcggct tcaaaggcgg caacctcgcc gccatgcagc 501 tyaaThis corresponds to the amino acid sequence <SEQ ID 1340; ORF 502.ng>:

m502.pep 1 MMKPHNLFQF LAVCSLTVAV ASAQAGAVDA LKQFNNDADG ISGSFTQXVQ 51XKKKTQTAHG TFKILRPGLF KWEYTKLYRQ TIVGDGQTVW LYDVDLAQVT 101 KSSQDQAIGXSPAAILSNKX ALESSYTLKE DGSSNGIDYV GNAQTQQRRL 151 PIHPHRLQRR QPRRHAAXComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 502 shows 95.8% identity over a 168 aa overlap with a predicted ORF(ORF 502.ng) from N. gonorrhoeae:

m502/g502         10        20        30        40        50        60m502.pep MMKPHNLFQFLAVCSLTVAVASAQAGAVDALKQFNNDADGISGSFTQXVQXKKKTQTAHG|||||||||||||||||||||||||||||||||||||||||||||||:|| ||||||||| g502MMKPHNLFQFLAVCSLTVAVASAQAGAVDALKQFNNDADGISGSFTQTVQSKKKTQTAHG        10        20        30        40        50        60        70        80        90       100       110       120 m502.pepTFKILRPGLFKWEYTKLYRQTIVGDGQTVWLYDVDLAQVTKSSQDQAIGXSPAAILSNKX|||||||||||||||  |||||||||||||||||||||||||||||||| |||||||||: g502TFKILRPGLFKWEYTLPYRQTIVGDGQTVWLYDVDLAQVTKSSQDQAIGGSPAAILSNKT        70        80        90       100       110       120       130       140        150       160 m502.pepALESSYTLKEDGSSNGIDYV-GNAQTQQRRLPIHPHRLQRRQPRRHAA|||||||||||||||||||| ||||||||||||||||||||||||||| g502ALESSYTLKEDGSSNGIDYVRGNAQTQQRRLPIHPHRLQRRQPRRHAA       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1341>:

a502.seq 1 ATGATGAAAC CGCACAACCT GTTCCAATTC CTCGCCGTTT GCTCCCTGAC 51CGTCTCCGTC GCTTCCGCAC AGGCGGGCGC GGTGGACGCG CTCAAGCAAT 101 TCAACAACGATGCCGACGGT ATCAGCGGCA GCTTCACCCA AACCGTCCAA 151 AGCAAAAAGA AAACCCAAACCGCGCACGGC ACGTTCAAAA TCCTGCGCCC 201 GGGCCTCTTT AAATGGGAAT ACACTTCGCCTTACAAACAG ACTATTGTCG 251 GCGACGGTCA AACCGTTTGG CTCTACGATG TCGATTTGGCACAAGTGACC 301 AAGTCGTCCC AAGACCAGGC CATAGGCGGC AGCCCCGCCG CCATCCTGTC351 GAACAAAACC GCCCTCGAAA GCAGCTACAC GCTGAAAGAG GACGGTTCGT 401CCAACGGCAT CGATTATGTG GGCAACGCCC AAACGCAACA ACGCCGGCTA 451 CCAATACATCCGCATCGGCT TCAAAGGCGG CAACCTCGCC GCCATGCAGC 501 TTAAThis corresponds to the amino acid sequence <SEQ ID 1342; 502 217.a>:

a502.pep 1 MMKPHNLFQF LAVCSLTVSV ASAQAGAVDA LKQFNNDADG ISGSFTQTVQ 51SKKKTQTAHG TFKILRPGLF KWEYTSPYKQ TIVGDGQTVW LYDVDLAQVT 101 KSSQDQAIGGSPAAILSNKT ALESSYTLKE DGSSNGIDYV GNAQTQQRRL 151 PIHPHRLQRR QPRRHAA*m502/a502 95.2% identity in 167 aa overlap        10        20        30        40        50        60 m502.pepMMKPHNLFQFLAVCSLTVAVASAQAGAVDALKQFNNDADGISGSFTQXVQXKKKTQTAHG||||||||||||||||||:||||||||||||||||||||||||||||:|| ||||||||| a502MMKPHNLFQFLAVCSLTVSVASAQAGAVDALKQFNNDADGISGSFTQTVQSKKKTQTAHG        10        20        30        40        50        60        70        80        90       100       110       120 m502.pepTFKILRPGLFKWEYTKLYRQTIVGDGQTVWLYDVDLAQVTKSSQDQAIGXSPAAILSNKX|||||||||||||||: |:|||||||||||||||||||||||||||||| |||||||||: a502TFKILRPGLFKWEYTSPYKQTIVGDGQTVWLYDVDLAQVTKSSQDQAIGGSPAAILSNKT        70        80        90       100       110       120       130       140       150       160 m502.pepALESSYTLKEDGSSNGIDYVGNAQTQQRRLPIHPHRLQRRQPRRHAAX|||||||||||||||||||||||||||||||||||||||||||||||| a502ALESSYTLKEDGSSNGIDYVGNAQTQQRRLPIHPHRLQRRQPRRHAAX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1343>:

g502-1.seq 1 ATGatGAAAc cgcaCaacct gttccaaTTc CTCGCCGTTT GCTCCCTGAC 51CGTCGCCGTC GCTTCCGCAC AGGCGGGCGC GGTGGACGCG CTCAAGCAAT 101 TCAACAACGATGCCGACGGT ATCAGCGGCA GCTTCACCCA AACCGTCCAA 151 AGCAAAAAGA AAACCCAAACCGCGCACGGC ACGTTCAAAA TCCTGCGCCC 201 GGGCCTCTTC AAATGGGAAT ACACTTTGCCCTACAGACAG ACTATTGTCG 251 GCGACGGTCA AACCGTTTGG CTCTACGATG TTGATTTGGCACAAGTGACC 301 AAGTCGTCCC AAGACCAGGC CATCGGCGGC AGCCCCGCCG CCATCCTGTC351 GAACAAAACC GCCCTCGAAA GCAGTTACAC GCTGAAAGAG GACGGTTCGT 401CCAACGGCAT CGATTATGTG CGGGCAACGC CCAAACGCAA CAACGCCGGC 451 TACCAATACATCCGCATCGG CTTCAAAGGC GGCAACCTCG CCGCCATGCA 501 GCTTAAAGAC AGCTTCGGCAACCAAACCTC CATCAGTTTC GGCGGTTTGA 551 ATACCAATCC CCAACTCTCG CGCGGCGCGTTCAAGTTTAC CCCGCCCAAA 601 GGCGTGGACG TGTTGAGCAA CTGAThis corresponds to the amino acid sequence <SEQ ID 1344; ORF 502-1.ng>:

g502-1.pep 1 MMKPHNLFQF LAVCSLTVAV ASAQAGAVDA LKQFNNDADG ISGSFTQTVQ 51SKKKTQTAHG TFKILRPGLF KWEYTLPYRQ TIVGDGQTVW LYDVDLAQVT 101 KSSQDQAIGGSPAAILSNKT ALESSYTLKE DGSSNGIDYV RATPKRNNAG 151 YQYIRIGFKG GNLAAMQLKDSFGNQTSISF GGLNTNPQLS RGAFKFTPPK 201 GVDVLSN*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1345>:

m502-1.seq 1 ATGATGAAAC CGCACAACCT GTTCCAATTC CTCGCCGTTT GCTCCCTGAC 51CGTCGCCGTC GCTTCCGCAC AGGCGGGCGC GGTAGACGCG CTTAAGCAAT 101 TCAACAACGATGCCGACGGT ATCAGCGGCA GCTTCACCCA AACCGTCCAA 151 AGCAAAAAGA AAACCCAAACCGCGCACGGC ACGTTCAAAA TCCTGCGACC 201 GGGCCTTTTC AAATGGGAAT ACACCAAACCTTACAGGCAA ACCATCGTCG 251 GCGACGGTCA AACCGTTTGG CTCTACGATG TTGATCTGGCACAAGTGACC 301 AAGTCGTCCC AAGACCAGGC CATAGGCGGC AGCCCCGCCG CCATCCTGTC351 GAACAAAACC GCCCTCGAAA GCAGCTACAC GCTGAAAGAG GACGGTTCGT 401CCAACGGCAT CGATTATGTG CTGGCAACGC CCAAACGCAA CAACGCCGGC 451 TACCAATACATCCGCATCGG CTTCAAAGGC GGCAACCTCG CCGCCATGCA 501 GCTTAAAGAC AGCTTCGGCAACCAAACCTC CATCAGTTTC GGCGGTTTGA 551 ATACCAATCC CCAACTCTCG CGCGGCGCGTTCAAGTTTAC CCCGCCCAAA 601 GGCGTGGACG TGTTGAGCAA CTGAThis corresponds to the amino acid sequence <SEQ ID 1346; ORF 502-1>:

m502-1.pep 1 MMKPHNLFQF LAVCSLTVAV ASAQAGAVDA LKQFNNDADG ISGSFTQTVQ 51SKKKTQTAHG TFKILRPGLF KWEYTKPYRQ TIVGDGQTVW LYDVDLAQVT 101 KSSQDQAIGGSPAAILSNKT ALESSYTLKE DGSSNGIDYV LATPKRNNAG 151 YQYIRIGFKG GNLAAMQLKDSFGNQTSISF GGLNTNPQLS RGAFKFTPPK 201 GVDVLSN* m502-1/g502-1 99.0%identity in 207 aa overlap        10        20        30        40        50        60 m502-1.pepMMKPHNLFQFLAVCSLTVAVASAQAGAVDALKQFNNDADGISGSFTQTVQSKKKTQTAHG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g502-1MMKPHNLFQFLAVCSLTVAVASAQAGAVDALKQFNNDADGISGSFTQLVQSKKKTQTAHG        10        20        30        40        50        60        70        80        90       100       110       120 m502-1.pepTFKILRPGLFKWEYTKPYRQTIVGDGQTVWLYDVDLAQVTKSSQDQAIGGSPAAILSNKT||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| g502-1TFKILRPGLFKWEYTLPYRQTIVGDGQTVWLYDVDLAQVTKSSQDQAIGGSPAAILSNKT        70        80        90       100       110       120       130       140       150       160       170       180 m502-1.pepALESSYLLKEDGSSNGIDYVLATPKRNNAGYQYIRIGFKGGNLAAMQLKDSFGNQTSISF|||||||||||||||||||| ||||||||||||||||||||||||||||||||||||||| g502-1ALESSYLLKEDGSSNGIDYVRATPKRNNAGYQYIRIGFKGGNLAAMQLKDSFGNQTSISF       130       140       150       160       170       180       190       200 m502-1.pep GGLNTNPQLSRGAFKFTPPKGVDVLSNX|||||||||||||||||||||||||||| g502-1 GGLNTNPQLSRGAFKFTPPKGVDVLSNX       190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1347>:

a502-1.seq 1 ATGATGAAAC CGCACAACCT GTTCCAATTC CTCGCCGTTT GCTCCCTGAC 51CGTCTCCGTC GCTTCCGCAC AGGCGGGCGC GGTGGACGCG CTCAAGCAAT 101 TCAACAACGATGCCGACGGT ATCAGCGGCA GCTTCACCCA AACCGTCCAA 151 AGCAAAAAGA AAACCCAAACCGCGCACGGC ACGTTCAAAA TCCTGCGCCC 201 GGGCCTCTTT AAATGGGAAT ACACTTCGCCTTACAAACAG ACTATTGTCG 251 GCGACGGTCA AACCGTTTGG CTCTACGATG TCGATTTGGCACAAGTGACC 301 AAGTCGTCCC AAGACCAGGC CATAGGCGGC AGCCCCGCCG CCATCCTGTC351 GAACAAAACC GCCCTCGAAA GCAGCTACAC GCTGAAAGAG GACGGTTCGT 401CCAACGGCAT CGATTATGTG CTGGCAACGC CCAAACGCAA CAACGCCGGC 451 TACCAATACATCCGCATCGG CTTCAAAGGC GGCAACCTCG CCGCCATGCA 501 GCTTAAAGAC AGCTTCGGCAATCAAACCTC CATCAGTTTC GGCGGTTTGA 551 ATACCAATCC CCAACTCTCG CGCGGCGCGTTCAAGTTTAC CCCGCCCAAA 601 GGCGTGGACG TGTTGAGCAA CTGAThis corresponds to the amino acid sequence <SEQ ID 1348; ORF 502-1.a>:

a502-1.pep 1 MMKPHNLFQF LAVCSLTVSV ASAQAGAVDA LKQFNNDADG ISGSFTQTVQ 51SKKKTQTAHG TFKILRPGLF KWEYTSPYKQ TIVGDGQTVW LYDVDLAQVT 101 KSSQDQAIGGSPAAILSNKT ALESSYTLKE DGSSNGIDYV LATPKRNNAG 151 YQYIRIGFKG GNLAAMQLKDSFGNQTSISF GGLNTNPQLS RGAFKFTPPK 201 GVDVLSN* a502-1/m502-1 98.6%identity in 207 aa overlap        10        20        30        40        50        60 a502-1.pepMMKPHNLFQFLAVCSLTVSVASAQAGAVDALKQFNNDADGISGSFTQTVQSKKKTQTAHG||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||| m502-1MMKPHNLFQFLAVCSLTVAVASAQAGAVDALKQFNNDADGISGSFTQTVQSKKKTQTAHG        10        20        30        40        50        60        70        80        90       100       110       120 a502-1.pepTFKILRPGLFKWEYTSPYKQTIVGDGQTVWLYDVDLAQVTKSSQDQAIGGSPAAILSNKT|||||||||||||||:||:||||||||||||||||||||||||||||||||||||||||| m502-1TFKILRPGLFKWEYTKPYRQTIVGDGQTVWLYDVDLAQVTKSSQDQAIGGSPAAILSNKT        70        80        90       100       110       120       130       140       150       160       170       180 a502-1.pepALESSYLLKEDGSSNGIDYVLATPKRNNAGYQYIRIGFKGGNLAAMQLKDSFGNQTSISF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m502-1ALESSYLLKEDGSSNGIDYVLATPKRNNAGYQYIRIGFKGGNLAAMQLKDSFGNQTSISF       130       140       150       160       170       180       190       200 a502-1.pep GGLNTNPQLSRGAFKFTPPKGVDVLSNX|||||||||||||||||||||||||||| m502-1 GGLNTNPQLSRGAFKFTPPKGVDVLSNX       190       200The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1349>:

g503.seq 1 atgtccgcgc cgtcggcatc ggtaatcatt ttgttccatg ccgcttcgat 51ttcggcatcg agctgttcgg ggaagggcgt gtccaaaatc cattggcgga 101 tttctttgccgacgcgtgcc agttcggaaa cgtcttcgac atccaatttt 151 gccagagcgg cggaaatgcgttcgttcaga ccgttgtgtg cgagaaatgc 201 gcggtagThis corresponds to the amino acid sequence <SEQ ID 1350; ORF 503.ng>:

g503.pep 1 MSAPSASVII LFHAASISAS SCSGKGVSKI HWRISLPTRA SSETSSTSNF 51ARAAEMRSFR PLCARNAR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1351>:

m503.seq 1 atgtccgcac cgccggcatc ggcaaccatt ttgttccatg ccgcttcgat 51ttcggcatcg agctgttcgg ggaaaggcgt atccaaaatc cattggcgga 101 tttctttgccgacgcgtgcc agttcggcaa cgtcttcgac atccaatttt 151 gccagtgcgg cggaaatgcgttcgctcaga ccgttgtgtg cgaggaatgc 201 gcggtagThis corresponds to the amino acid sequence <SEQ ID 1352; ORF 503>:

m503.pep 1 MSAPPASATI LFHAASISAS SCSGKGVSKI HWRISLPTRA SSATSSTSNF 51ASAAEMRSLR PLCARNAR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae ORF 503 shows 91.2%identity over a 68 aa overlap with a predicted ORF (ORF 503.ng) from N.gonorrhoeae:

m503/g503         10        20        30        40        50        60m503.pep MSAPPASATILFHAASISASSCSGKGVSKIHWRISLPTRASSATSSTSNFASAAEMRSLR|||| ||: ||||||||||||||||||||||||||||||||| |||||||| ||||||:| g503MSAPSASVIILFHAASISASSCSGKGVSKIHWRISLPTRASSETSSISNFARAAEMRSFR        10        20        30        40        50        60        69m503.pep PLCARNAR |||||||| g503 PLCARNARThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1353>:

a503.seq 1 ATGTCCGCGC CGCCGGCATC GGCAACCATT TTGTTCCATG CCGCTTCGAT 51TTCGGCATCG AGCTGTTCGG GGAAGGGCGT GTCCAAAATC CATTGGCGGA 101 TTTCTTTGCCGACGCGTGCC AGTTCGGCAA CGTCTTCGAC ATCTAATTTT 151 GCCAGTGCGG CGGAAATGCGTTCGCTCAGA CCGTTGTGTG CGAGGAATGC 201 GCGGTAGThis corresponds to the amino acid sequence <SEQ ID 1354; ORF 503.a>:

a503.pep 1 MSAPPASATI LFHAASISAS SCSGKGVSKI HWRISLPTRA SSATSSTSNF 51ASAAEMRSLR PLCARNAR* m503/a503 100.0% identity in 68 aa overlap        10        20        30        40        50        60 m503.pepMSAPPASATILFHAASISASSCSGKGVSKIHWRISLPTRASSATSSTSNFASAAEMRSLR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a503MSAPPASATILFHAASISASSCSGKGVSKIHWRISLPTRASSATSSISNFASAAEMRSLR        10        20        30        40        50        60        69m503.pep PLCARNARX ||||||||| a503 PLCARNARXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1355>:

g503-1.seq 1 ATGGCGCGGT CGTTGTACAG GGAGGCGAAA ACGTGGCGCA TCGCTTTTTT 51AACGTTATCC AAGCCATTGA TATTCAGGAA GGTTTCCTGT TGGCCGGCAA 101 ATGATGCGTCGGGCAGGTCT TCGGCGGTTG CGGAAGAGCG TACGGCAACG 151 GAAATGTCCG CGCCGTCGGCATCGGTAATC ATTTTGTTCC ATGCCGCTTC 201 GATTTCGGCA TCGAGCTGTT CGGGGAAGGGCGTGTCCAAA ATCCATTGGC 251 GGATTTCTTT GCCGACGCGT GCCAGTTCGG AAACGTCTTCGACATCCAAT 301 TTTGCCAGAG CGGCGGAAAT GCGTTCGTTC AGACCGTTGT GTGCGAGAAA351 TGCGCGGTAGThis corresponds to the amino acid sequence <SEQ ID 1356; ORF 214.ng>:

g503-1.pep 1 MARSLYREAK TWRIAFLTLS KPLIFRKVSC WPANDASGRS SAVAEERTAT 51EMSAPSASVI ILFHAASISA SSCSGKGVSK IHWRISLPTR ASSETSSTSN 101 FARAAEMRSFRPLCARNAR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1357>:

m503-1.seq 1 ATGGCACGGT CGTTATACAG GGAAGCGAAT ACATGGTGCA TCGCTTCTTT 51AACGTTATCC AAGCCGTTGA TGTTCAAGAA GGTTTCCTGT TGTCCAGCGA 101 ATGATGCGTCCGGCAGGTCT TCGGCAGTTG CGGAAGAACG TACGGCAACG 151 GAAATGTCCG CACCGCCGGCATCGGCAACC ATTTTGTTCC ATGCCGCTTC 201 GATTTCGGCA TCGAGCTGTT CGGGGAAAGGCGTATCCAAA ATCCATTGGC 251 GGATTTCTTT GCCGACGCGT GCCAGTTCGG CAACGTCTTCGACATCCAAT 301 TTTGCCAGTG CGGCGGAAAT GCGTTCGCTC AGACCGTTGT GTGCGAGGAA351 TGCGCGGTAGThis corresponds to the amino acid sequence <SEQ ID 1358; ORF 503-1>:

m503-1.pep 1 MARSLYREAN TWCIASLTLS KPLMFKKVSC CPANDASGRS SAVAEERTAT 51EMSAPPASAT ILFHAASISA SSCSGKGVSK IHWRISLPTR ASSATSSTSN 101 FASAAEMRSLRPLCARNAR* g503-1/m503-1 89.9% identity in 119 aa overlap        10        20        30        40        50        60 g503-1.pepMARSLYREAKTWRIAFLTLSKPLIFRKVSCWPANDASGRSSAVAEERTATEMSAPSASVI|||||||||:|| || |||||||:|:|||| |||||||||||||||||||||||| ||: m503-1MARSLYREANTWCIASLTLSKPLMFKKVSCCPANDASGRSSAVAEERTATEMSAPPASAT        10        20        30        40        50        60        70        80        90       100       110       120 g503-1.pepILFHAASISASSCSGKGVSKIHWRISLPTRASSETSSTSNFARAAEMRSFRPLCARNARX||||||||||||||||||||||||||||||||| |||||||| ||||||:|||||||||| m503-1ILFHAASISASSCSGKGVSKIHWRISLPTRASSATSSTSNFASAAEMRSLRPLCARNARX        70        80        90       100       110       120The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1359>:

a503-1.seq 1 ATGGCGCGGT CGTTGTACAG GGAGGCGAAT ACATGGCGCA TCGCTTCTTT 51AACGTTTTCC AAGCCGTTGA TATTCAGGAA GGTTTCCTGT TGGCCGGCAA 101 ATGATGCGTCGGGCAGGTCT TCGGCGGTTG CGGAAGAGCG TACGGCAACG 151 GAAATGTCCG CGCCGCCGGCATCGGCAACC ATTTTGTTCC ATGCCGCTTC 201 GATTTCGGCA TCGAGCTGTT CGGGGAAGGGCGTGTCCAAA ATCCATTGGC 251 GGATTTCTTT GCCGACGCGT GCCAGTTCGG CAACGTCTTCGACATCTAAT 301 TTTGCCAGTG CGGCGGAAAT GCGTTCGCTC AGACCGTTGT GTGCGAGGAA351 TGCGCGGTAGThis corresponds to the amino acid sequence <SEQ ID 1360; ORF 503-1.a>:

a503-1.pep 1 MARSLYREAN TWRIASLTFS KPLIFRKVSC WPANDASGRS SAVAEERTAT 51EMSAPPASAT ILFHAASISA SSCSGKGVSK IHWRISLPTR ASSATSSTSN 101 FASAAEMRSLRPLCARNAR* a503-1/m503-1 95.8% identity in 119 aa overlap        10        20        30        40        50        60 a503-1.pepMARSLYREANTWRIASLTFSKPLIFRKVSCWPANDASGRSSAVAEERTATEMSAPPASAT|||||||||||| |||||:||||:|:|||| ||||||||||||||||||||||||||||| m503-1MARSLYREANTWCIASLTLSKPLMFKKVSCCPANDASGRSSAVAEERTATEMSAPPASAT        10        20        30        40        50        60        70        80        90       100       110       120 a503-1.pepILFHAASISASSCSGKGVSKIHWRISLPTRASSATSSTSNFASAAEMRSLRPLCARNARX|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m503-1ILFHAASISASSCSGKGVSKIHWRISLPTRASSATSSTSNFASAAEMRSLRPLCARNARX        70        80        90       100       110       120The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1361>:

g504.seq 1 atgttggttc aggacttgcc ttttgaagtc aaactgaaaa aattccatat 51cgatttttac aatacgggta tgccgcgcga ttttgccagc gatattgaag 101 taacggacaaggcaaccggt gagaaactcg agcgcaccat ccgcgtgaac 151 catcctttga ccttgcacggcatcacgatt tatcaggcga gttttgccga 201 cggcggttcg gatttgacat tcaaggcgtggaatttgagg gatgcttcgc 251 gcgaacctgt cgtgttgaag gcaacctcca tacaccagtttccgttggaa 301 atcggcaaac acaaatatcg tcttgagttc gatcagttca cttctatgaa351 tgtggaggac atgagcgagg gtgcggaacg ggaaaaaagc ctgaaatcca 401ctctgaacga tgtccgcgcc gttactcagg aaggtaaaaa atacaccaat 451 atcggcccttccatcgtgta ccgcatccgt gatgcggcag ggcaggcggt 501 cgaatataaa aactatatgctgccgatttt gcaggacaaa gattattttt 551 ggctgaccgg cacgcgcagc ggcttgcagcagcaataccg ctggctgcgt 601 atccccttgg acaagcagtt gaaagcggac acctttatggcattgcgtga 651 gtttttgaaa gatggggaag ggcgcaaacg tctggttgcc gacgcaacca701 aagacgcacc tgccgaaatc cgcgaacaat tcatgctggc tgcggaaaac 751acgctgaata tctttgcgca aaaaggctat ttgggattgg acgaatttat 801 tacgtccaatatcccgaaag ggcagcagga taagatgcag ggctatttct 851 acgaaatgct ttacggcgtgatgaacgctg ctttggatga aaccatacgc 901 cggtacggct tgcccgaatg gcagcaggatgaagcgcgga accgtttcct 951 gctgcacagt atggatgcct atacggggct gacggaatatcccgcgccta 1001 tgctgctcca gcttgacggg ttttccgagg tgcgttcctc aggtttgcag1051 atgacccgtt cgccgggtgc gcttttggtc tatctcggct cggtattgtt 1101ggttttgggt acagtattta tgttttatgt gcccaaaaaa cgggcgtggg 1151 tattgttttcaaacdgcaaa atccgttttg ctatgtcttc ggcccgcagc 1201 gaacgggatt tgcagaaggaatttccaaaa cacgtcgaga gcctgcaacg 1251 gctcggcaag gacttgaatc atgactgaThis corresponds to the amino acid sequence <SEQ ID 1362; ORF 504.ng>:

g504.pep 1 MLVQDLPFEV KLKKFHIDFY NTGMPRDFAS DIEVTDKATG EKLERTIRVN 51HPLTLHGITI YQASFADGGS DLTFKAWNLR DASREPVVLK ATSIHQFPLE 101 IGKHKYRLEFDQFTSMNVED MSEGAEREKS LKSTLNDVRA VTQEGKKYTN 151 IGPSIVYRIR DAAGQAVEYKNYMLPILQDK DYFWLTGTRS GLQQQYRWLR 201 IPLDKQLKAD TFMALREFLK DGEGRKRLVADATKDAPAEI REQFMLAAEN 251 TLNIFAQKGY LGLDEFITSN IPKGQQDKMQ GYFYEMLYGVMNAALDETIR 301 RYGLPEWQQD EARNRFLLHS MDAYTGLTEY PAPMLLQLDG FSEVRSSGLQ351 MTRSPGALLV YLGSVLLVLG TVFMFYVPKK RAWVLFSNKI RFAMSSARSE 401RDLQKEFPKH VESLQRLGKD LNHD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1363>:

m504.seq.. 1 atattggttc aggacttgcc ttttgaagtc aaactgaaaa aattccatat 51cgatttttac aatacgggta tgccgcgtga tttcgccagc gatattgaag 101 tgacggacaaggcaaccggt gagaaactcg agcgcaccat ccgcgtgaac 151 catcctttga ccttgcacggcatcacgatt tatcaggcga gttttgccga 201 cggcggttcg gatttgacat tcaaggcgtggaatttgggt gatgcttcgc 251 gcgagcctgt cgtgttgaag gcaacatcca tacaccagtttccgttggaa 301 attggcaaac acaaatatcg tcttgagttc gatcagttca cttctatgaa351 tgtggaggac atgagcgagg gcgcggaacg ggaaaaaagc ctgaaatcca 401cgctgmmcga tgtccgcgcc gttactcagg aaggtaaaaa atacaccaat 451 atcggcccttccattgttta ccgtatccgt gatgcggcag ggcaggcggt 501 cgaatataaa aactatatgctgccggtttt gcaggaacag gattattttt 551 ggattaccgg cacgcgcagc ggcttgcagcagcaataccg ctggctgcgt 601 atccccttgg acaagcagtt gaaagcggac acctttatggcattgcgtga 651 gtttttgaaa gatggggaag ggcgcaaacg tctggttgcc gacgcaacca701 aaggcgcacc tgccgaaatc cgcgaacaat tcatgctggc tgcggaaaac 751acgctgaaca tctttgcaca aaaaggctat ttgggattgg acgaatttat 801 tacgtccaatatcccgaaag agcagcagga taagatgcag ggctatttct 851 acgaaatgct ttacggcgtgatgaacgctg ctttggatga aaccatacgc 901 cggtacggct tgcccgaatg gcagcaggatgaagcgcgga atcgtttcct 951 gctgcacagt atggatgcgt acacgggttt gaccgaatatcccgcgccta 1001 tgctgctgca acttgatggg ttttccgagg tgcgttcgtc gggtttgcag1051 atgacccgtt ccccgggtgc gcttttggtc tatctcggct cggtgctgtt 1101ggtattgggt acggtattga tgttttatgt gcgcgaaaaa cgggcgtggg 1151 tattgttttcagacggcaaa atccgttttg ccatgtcttc ggcccgcagc 1201 gaacgggatt tgcagaaggaatttccaaaa cacgtcgaga gtctgcaacg 1251 gctcggcaag gacttgaatc atgaThis corresponds to the amino acid sequence <SEQ ID 1364; ORF 504>:

m504.pep.. 1 ILVQDLPFEV KLKKFHIDFY NTGMPRDFAS DIEVTDKATG EKLERTIRVN 51HPLTLHGITI YQASFADGGS DLTFKAWNLG DASREPVVLK ATSIHQFPLE 101 IGKHKYRLEFDQFTSMNVED MSEGAEREKS LKSTLXDVRA VTQEGKKYTN 151 IGPSIVYRIR DAAGQAVEYKNYMLPVLQEQ DYFWITGTRS GLQQQYRWLR 201 IPLDKQLKAD TFMALREFLK DGEGRKRLVADATKGAPAEI REQFMLAAEN 251 TLNIFAQKGY LGLDEFITSN IPKEQQDKMQ GYFYEMLYGVMNAALDETIR 301 RYGLPEWQQD EARNRFLLHS MDAYTGLTEY PAPMLLQLDG FSEVRSSGLQ351 MTRSPGALLV YLGSVLLVLG TVLMFYVREK RAWVLFSDGK IRFAMSSARS 401ERDLQKEFPK HVESLQRLGK DLNHD*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 504 shows 96.7% identity over a 425 aa overlap with a predicted ORF(ORF 504.ng) from N. gonorrhoeae:

m504/g504           10        20        30        40        50        60m504.pep   ILVQDLPFEVKLKKFHIDFYNTGMPRDFASDIEVTDKATGEKLERTIRVNHPLTLHGITI  :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g504  MLVQDLPFEVKLKKFHIDFYNTGMPRDFASDIEVTDKATGEKLERTIRVNHPLTLHGITI          10        20        30        40        50        60          70        80        90       100       110       120 m504.pep  YQASFADGGSDLTFKAWNLGDASREPVVLKATSIHQFPLEIGKHKYRLEFDQFTSMNVED  ||||||||||||||||||| |||||||||||||||||||||||||||||||||||||||| g504  YQASFADGGSDLTFKAWNLRDASREPVVLKATSIHQFPLEIGKHKYRLEFDQFTSMNVED          70        80        90       100       110       120         130       140       150       160       170       180 m504.pep  MSEGAEREKSLKSTLXDVRAVTQEGKKYTNIGPSIVYRIRDAAGQAVEYKNYMLPVLQEQ  ||||||||||||||| |||||||||||||||||||||||||||||||||||||||: ||: : g504  MSEGAEREKSLKSTLNDVRAVTQEGKKYTNIGPSIVYRIRDAAGQAVEYKNYMLPILQDK         130       140       150       160       170       180         190       200       210       220       230       240 m504.pep  DYFWITGTRSGLQQQYRWLRIPLDKQLKADTFMALREFLKDGEGRKRLVADATKGAPAEI  ||||:||||||||||||||||||||||||||||||||||||||||||||||||| ||||| g504  DYFWLTGTRSGLQQQYRWLRIPLDKQLKADTFMALREFLKDGEGRKRLVADATKDAPAEI         190       200       210       220       230       240         250       260       270       280       290       300 m504.pep  REQFMLAAENTLNIFAQKGYLGLDEFITSNIPKEQQDKMQGYFYEMLYGVMNAALDETIR  ||||||||||||||||||||||||||||||||| |||||||||||||||||||||||||| g504  REQFMLAAENTLNIFAQKGYLGLDEFITSNIPKGQQDKMQGYFYEMLYGVMNAALDETIR         250       260       270       280       290       300         310       320       330       340       350       360 m504.pep  RYGLPEWQQDEARNRFLLHSMDAYTGLTEYPAPMLLQLDGFSEVRSSGLQMTRSPGALLV  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g504  RYGLPEWQQDEARNRFLLHSMDAYTGLTEYPAPMLLQLDGFSEVRSSGLQMTRSPGALLV         310       320       330       340       350       360         370       380       390       400       410       420 m504.pep  YLGSVLLVLGTVLMFYVREKRAWVLFSDGKIRFAMSSARSERDLQKEFPKHVESLQRLGK  ||||||||||||:|||| :||||||||: ||||||||||||||||||||||||||||||| g504  YLGSVLLVLGTVFMFYVPKKRAWVLFSN-KIRFAMSSARSERDLQKEFPKHVESLQRLGK         370       380        390       400       410 m504.pep   DLNHD  ||||| g504   DLNHD 420The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1365>:

a504.seq 1 ATATTGGTTC AGGACTTGCC TTTTGAAGTC AAACTGAAAA AATTCCATAT 51CGATTTTTAC AATACGGGTA TGCCGCGCGA TTTTGCCAGT GATATTGAAG 101 TAACGGATAAGGCAACCGGT GAGAAACTCG AGCGCACCAT CCGCGTGAAC 151 CATCCTTTGA CCTTGCACGGCATCACGATT TATCAGGCGA GTTTTGCCGA 201 CGGCGGTTCG GATTTGACAT TCAAGGCGTGGAATTTGGGT GATGCTTCGC 251 GCGAGCCTGT CGTGTTGAAG GCAACATCCA TACACCAGTTTCCGTTGGAA 301 ATTGGCAAAC ACAAATATCG TCTTGAGTTC GATCAGTTTA CTTCTATGAA351 TGTGGAGGAC ATGAGCGAGG GCGCGGAACG GGAAAAAAGC CTGAAATCCA 401CGCTGAACGA TGTCCGCGCC GTTACTCAGG AAGGTAAAAA ATACACCAAT 451 ATCGGCCCTTCCATTGTTTA CCGTATCCGT GATGCGGCAG GGCAGGCGGT 501 CGAATATAAA AACTATATGCTGCCGGTTTT GCAGGAACAG GATTATTTTT 551 GGATTACCGG CACGCGCAGC GGCTTGCAGCAGCAATACCG CTGGCTGCGT 601 ATCCCCTTGG ACAAGCAGTT GAAAGCGGAC ACCTTTATGGCATTGCGTGA 651 GTTTTTGAAA GATGGGGAAG GGCGCAAACG TCTGGTTGCC GACGCAACCA701 AAGGCGCACC TGCCGAAATC CGCGAACAAT TCATGCTGGC TGCGGAAAAC 751ACGCTGAACA TCTTTGCACA AAAAGGCTAT TTGGGATTGG ACGAATTTAT 801 TACGTCCAATATCCCGAAAG AGCAGCAGGA TAAGATGCAG GGCTATTTCT 851 ACGAAATGCT TTACGGCGTGATGAACGCTG CTTTGGATGA AACCATACGC 901 CGGTACGGCT TGCCCGAATG GCAGCAGGATGAAGCGCGGA ATCGTTTCCT 951 GCTGCACAGT ATGGATGCGT ACACGGGTTT GACCGAATATCCCGCGCCTA 1001 TGCTGCTGCA ACTTGATGGG TTTTCCGAGG TGCGTTCGTC GGGTTTGCAG1051 ATGACCCGTT CCCCGGGTGC GCTTTTGGTC TATCTCGGCT CGGTGCTGTT 1101GGTATTGGGT ACGGTATTGA TGTTTTATGT GCGCGAAAAA CGGGCGTGGG 1151 TATTGTTTTCAGACGGCAAA ATCCGTTTTG CCATGTCTTC GGCTTGCAGC 1201 GAACGGGATT TGCAGAAGGAATTTCCAAAA CACGTCGAGA GTCTGCAACG 1251 GCTCGGCAAG GACTTGAATC ATGACTGAThis corresponds to the amino acid sequence <SEQ ID 1366; ORF 504.a>:

a504.pep 1 ILVQDLPFEV KLKKFHIDFY NTGMPRDFAS DIEVTDKATG EKLERTIRVN 51HPLTLHGITI YQASFADGGS DLTFKAWNLG DASREPVVLK ATSIHQFPLE 101 IGKHKYRLEFDQFTSMNVED MSEGAEREKS LKSTLNDVRA VTQEGKKYTN 151 IGPSIVYRIR DAAGQAVEYKNYMLPVLQEQ DYFWITGTRS GLQQQYRWLR 201 IPLDKQLKAD TFMALREFLK DGEGRKRLVADATKGAPAEI REQFMLAAEN 251 TLNIFAQKGY LGLDEFITSN IPKEQQDKMQ GYFYEMLYGVMNAALDETIR 301 RYGLPEWQQD EARNRFLLHS MDAYTGLTEY PAPMLLQLDG FSEVRSSGLQ351 MTRSPGALLV YLGSVLLVLG TVLMFYVREK RAWVLFSDGK IRFAMSSARS 401ERDLQKEFPK HVESLQRLGK DLNHD* m504/a504 99.8% identity in 425 aa overlap        10        20        30        40        50        60 m504.pepILVQDLPFEVKLKKFHIDFYNTGMPRDFASDIEVTDKATGEKLERTIRVNHPLTLHGITI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a504ILVQDLPFEVKLKKFHIDFYNTGMPRDFASDIEVTDKATGEKLERTIRVNHPLTLHGITI        10        20        30        40        50        60        70        80        90       100       110       120 m504.pepYQASFADGGSDLTFKAWNLGDASREPVVLKATSIHQFPLEIGKHKYRLEFDQFTSMNVED|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a504YQASFADGGSDLTFKAWNLGDASREPVVLKATSIHQFPLEIGKHKYRLEFDQFTSMNVED        70        80        90       100       110       120       130       140       150       160       170       180 m504.pepMSEGAEREKSLKSTLXDVRAVTQEGKKYTNIGPSIVYRIRDAAGQAVEYKNYMLPVLQEQ||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| a504MSEGAEREKSLKSTLNDVRAVTQEGKKYTNIGPSIVYRIRDAAGQAVEYKNYMLPVLQEQ       130       140       150       160       170       180       190       200       210       220       230       240 m504.pepDYFWITGTRSGLQQQYRWLRIPLDKQLKADTFMALREFLKDGEGRKRLVADATKGAPAEI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a504DYFWITGTRSGLQQQYRWLRIPLDKQLKADTFMALREFLKDGEGRKRLVADATKGAPAEI       190       200       210       220       230       240       250       260       270       280       290       300 m504.pepREQFMLAAENTLNIFAQKGYLGLDEFITSNIPKEQQDKMQGYFYEMLYGVMNAALDETIR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a504REQFMLAAENTLNIFAQKGYLGLDEFITSNIPKEQQDKMQGYFYEMLYGVMNAALDETIR       250       260       270       280       290       300       310       320       330       340       350       360 m504.pepRYGLPEWQQDEARNRFLLHSMDAYTGLTEYPAPMLLQLDGFSEVRSSGLQMTRSPGALLV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a504RYGLPEWQQDEARNRFLLHSMDAYTGLTEYPAPMLLQLDGFSEVRSSGLQMTRSPGALLV       310       320       330       340       350       360       370       380       390       400       410       420 m504.pepYLGSVLLVLGTVLMFYVREKRAWVLFSDGKIRFAMSSARSERDLQKEFPKHVESLQRLGK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a504YLGSVLLVLGTVLMFYVREKRAWVLFSDGKIRFAMSSARSERDLQKEFPKHVESLQRLGK       370       380       390       400       410       420 m504.pepDLNHDX |||||| a504 DLNHDXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1367>:

g505.seq 1 atgtttcgtt tacaattcag gctgtttccc cctttgcgaa ccgccatgca 51catcctgttg accgccctgc tcaaatgcct ctccctgctg tcgctttcct 101 gtctgcacacgctgggaaac cggctcggac atctggcgtt ttacctttta 151 aaggaagacc gcgcgcgcatcgtcgccaat atgcggcagg cgggtttgaa 201 ccccgacacg cagacggtca aagccgtttttgcggaaacg gcaaaatgcg 251 gtttggaact tgcccccgcg tttttcaaaa aaccggaagacatcgaaaca 301 atgttcaaag cggtacacgg ctgggaacac gtgcagcagg ctttggacaa351 gggcgaaggg ctgctgttca tcacgccgca catcggcagc tacgatttgg 401gcggacgcta catcagccag cagcttccgt tccacctgac cgccatgtac 451 aagccgccgaaaatcaaagc gatagacaaa atcatgcagg cgggcagggt 501 gcgcggcaaa ggcaaaaccgcgcccaccgg catacaaggg gtcaaacaaa 551 tcatcaaggc cctgcgcgcg ggcgaggcaaccatcatcct gcccgaccac 601 gtcccttctc cgcaggaagg cggcggcgtg tgggcggattttttcggcaa 651 acctgcatac accatgacac tggcggcaaa attggcacac gtcaaaggcg701 tgaaaaccct gtttttctgc tgcgaacgcc tgcccgacgg acaaggcttc 751gtgttgcaca tccgccccgt ccaaggggaa ttgaacggca acaaagccca 801 cgatgccgccgtgttcaacc gcaataccga atattggata cgccgttttc 851 cgacgcagta tctgtttatgtacaaccgct ataaaacgcc gtaaThis corresponds to the amino acid sequence <SEQ ID 1368; ORF 505.ng>:

g505.pep 1 MFRLQFRLFP PLRTAMHILL TALLKCLSLL SLSCLHTLGN RLGHLAFYLL 51KEDRARIVAN MRQAGLNPDT QTVKAVFAET AKCGLELAPA FFKKPEDIET 101 MFKAVHGWEHVQQALDKGEG LLFITPHIGS YDLGGRYISQ QLPFHLTAMY 151 KPPKIKAIDK IMQAGRVRGKGKTAPTGIQG VKQIIKALRA GEATIILPDH 201 VPSPQEGGGV WADFFGKPAY TMTLAAKLAHVKGVKTLFFC CERLPDGQGF 251 VLHIRPVQGE LNGNKAHDAA VFNRNTEYWI RRFPTQYLFMYNRYKTP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1369>:

m505.seq (partial) 1 GGCATGTTTC GTTTACAATT CAGGCTGTTT CCCCCTTTGCGAACCGCCAT 51 GCACATCCTG TTGACCGCCC TGCTCAAATG CCTCTCCCTG CTGCCGCTTT 101CCTGTCTGCA CACGCTGGGA AACCGGCTCG GACATCTGGC GTTTTACCTT 151 TTAAAGGAAGACCGCGCGCG CATCGTCGCC AATATGCGGC AGGCGGGTTT 201 GAACCCCGAC CCCAAAACGGTCAAAGCCGT TTTTGCGGAA ACGGCAAAAG 251 GCGGTTTGGA ACTTGCCCCC GCGTTTTTCAGAAAACCGGA AGACATAGAA 301 ACAATGTTCA AAGCGGTACA CGGCTGGGAA CATGTGCAGCAGGCTTTGGA 351 CAAACACGAA GGGCTGCTAT TCATCACGCC GCACATCGGC AGCTACGATT401 TGGGCGGACG CTACATCAGC CAGCAGCTTC CGTTCCCGCT GACCGCCATG 451TACAAACCGC CGAAAATCAA AGCGATAGAC AAAATCATGC AGGCGGGCAG 501 GGTTCGCGGCAAAGGAAAAA CCGCGCCTAC CAGCATACAA GGGGTCAAAC 551 AAATCATCAA AGCCCTGCGTTCGGGCGAgC AACCATCGTC CTGCCCGACC 601 ACGTCCCCTC CCCTCAAGAA GGCGGGGAAGGCGTATGGGT GGATTTCTTC 651 GGCAAACCTG CCTATACCAT GACGCTGGCG GCAArATTGGCACACGTCAA 701 AGGCGTGAAA ACCCTGTTTT TCTGCTGCGA ACGCCTGCCT GGCGGACAAG751 GTTTCGATTT GCACATCCGC CCCGTCCAAG GGGAATTGAA CGGCGACAAA 801GCCCATGATG CCGCCGTGTT CAACCGCAAT GCCGAATATT GGATACGCCG 851 TTTTCCGACGCAtATC....This corresponds to the amino acid sequence <SEQ ID 1370; ORF 505>:

m505.pep (partial) 1 MFRLQFRLFP PLRTAMHILL TALLKCLSLL PLSCLHTLGNRLGHLAFYLL 51 KEDRARIVAN MRQAGLNPDP KTVKAVFAET AKGGLELAPA FFRKPEDIET 101MFKAVHGWEH VQQALDKHEG LLFITPHIGS YDLGGRYISQ QLPFPLTAMY 151 KPPKIKAIDKIMQAGRVRGK GKTAPTSIQG VKQIIKALRS GEATIVLPDH 201 VPSPQEGGEG VWVDFFGKPAYTMTLAAXLA HVKGVKTLFF CCERLPGGQG 251 FDLHIRPVQG ELNGDKAHDA AVFNRNAEYWIRRFPTHI...Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 505 shows 93.7% identity over a 287 aa overlap with a predicted ORF(ORF 505.ng) from N. gonorrhoeae:

m505/g505           10        20        30        40        50        60m505.pep   MFRLQFRLFPPLRTAMHILLTALLKOLSLLPLSCLHTLGNRLGHLAFYLLKEDRARIVAN  |||||||||||||||||||||||||||||| ||||||||||||||||||||||||||||| g505  MFRLQFRLFPPLRTAMHILLTALLKCLSLLSLSCLHTLGNRLGHLAFYLLKEDRARIVAN          10        20        30        40        50        60          70        80        90       100       110       120 m505.pep  MRQAGLNPDPKTVKAVFAETAKGGLELAPAFFRKPEDIETMFKAVHGWEHVQQALDKHEG  ||||||||| :||||||||||| |||||||||:|||||||||||||||||||||||| || g505  MRQAGLNPDTQTVKAVFAETAKCGLELAPAFFKKPEDIETMFKAVHGWEHVQQALDKGEG          70        80        90       100       110       120         130       140       150       160       170       180 m505.pep  LLFITPHIGSYDLGGRYISQQLPFPLTAMYKPPKIKAIDKIMQAGRVRGKGKTAPTSIQG  |||||||||||||||||||||||| |||||||||||||||||||||||||||||||:||| g505  LLFITPHIGSYDLGGRYISQQLPFHLTAMYKPPKIKAIDKIMQAGRVRGKGKTAPTGIQG         130       140       150       160       170       180         190       200       210       220       230       240 m505.pep  VKQIIKALRSGEATIVLPDHVPSPQEGGEGVWVDFFGKPAYTMTLAAXLAHVKGVKILFF  |||||||||:|||||:|||||||||||| |||:|||||||||||||| |||||||||||| g505  VKQIIKALRAGEATIILPDHVPSPQEGG-GVWADFFGKPAYTMTLAAKLAHVKGVKTLFF         190       200       210       220       230         250       260       270      280       289 m505.pep  CCERLPGGQGFDLHIRPVQGELNGDKAHDAAVFNRNAEYWIRRFPTHI  |||||| |||| ||||||||||||:|||||||||||:|||||||||: g505  CCERLPDGQGFVLHIRPVQGELNGNKAHDAAVFNRNTEYWIRRFPTQYLFMYNRYKTP240       250       260       270       280       290The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1371>:

a505.seq 1 ATGTTTCGTT TACAATTCAG GCTGTTTCCC CCTTTGCGAA CCGCCATGCA 51CATCCTGTTG ACCGCCCTGC TCAAATGCCT CTCCCTGCTG CCGCTTTCCT 101 GTCTGCACACGCTGGGAAAC CGGCTCGGAC ATCTGGCGTT TTACCTTTTA 151 AAGGAAGACC GCGCGCGCATCGTCGCCAAT ATGCGTCAGG CAGGCATGAA 201 TCCCGACCCC AAAACGGTCA AAGCCGTTTTTGCGGAAACG GCAAAAGGCG 251 GTTTGGAACT TGCCCCCGCG TTTTTCAGAA AACCGGAAGACATAGAAACA 301 ATGTTCAAAG CGGTACACGG CTGGGAACAT GTGCAGCAGG CTTTGGACAA351 ACACGAAGGG CTGCTATTCA TCACGCCGCA CATCGGCAGC TACGATTTGG 401GCGGACGCTA CATCAGCCAG CAGCTTCCGT TCCCGCTGAC CGCCATGTAC 451 AAACCGCCGAAAATCAAAGC GATAGACAAA ATCATGCAGG CGGGCAGGGT 501 TCGCGGCAAA GGAAAAACCGCGCCTACCAG CATACAAGGG GTCAAACAAA 551 TCATCAAAGC CCTGCGTTCG GGCGAAGCAACCATCGTCCT GCCCGACCAC 601 GTCCCCTCCC CTCAAGAAGG CGGGGAAGGC GTATGGGTGGATTTCTTCGG 651 CAAACCTGCC TATACCATGA CGCTGGCGGC AAAATTGGCA CACGTCAAAG701 GCGTGAAAAC CCTGTTTTTC TGCTGCGAAC GCCTGCCTGG CGGACAAGGT 751TTCGATTTGC ACATCCGCCC CGTCCAAGGG GAATTGAACG GCGACAAAGC 801 CCATGATGCCGCCGTGTTCA ACCGCAATGC CGAATATTGG ATACGCCGTT 851 TTCCGACGCA GTATCTGTTTATGTACAACC GCTACAAAAT GCCGTAAThis corresponds to the amino acid sequence <SEQ ID 1372; ORF 505.a>:

a505.pep 1 MFRLQFRLFP PLRTAMHILL TALLKCLSLL PLSCLHTLGN RLGHLAFYLL 51KEDRARIVAN MRQAGMNPDP KTVKAVFAET AKGGLELAPA FFRKPEDIET 101 MFKAVHGWEHVQQALDKHEG LLFITPHIGS YDLGGRYISQ QLPFPLTAMY 151 KPPKIKAIDK IMQAGRVRGKGKTAPTSIQG VKQIIKALRS GEATIVLPDH 201 VPSPQEGGEG VWVDFFGKPA YTMTLAAKLAHVKGVKTLFF CCERLPGGQG 251 FDLHIRPVQG ELNGDKAHDA AVFNRNAEYW IRRFPTQYLFMYNRYKMP* m505/a505 99.0% identity in 287 aa overlap        10        20        30        40        50        60 m505.pepMFRLQFRLFPPLRTAMHILLTALLKCLSLLPLSCLHTLGNRLGHLAFYLLKEDRARIVAN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a505MFRLQFRLFPPLRTAMHILLTALLKCLSLLPLSCLHTLGNRLGHLAFYLLKEDRARIVAN        10        20        30        40        50        60        70        80        90       100       110       120 m505.pepMRQAGLNPDPKTVKAVFAETAKGGLELAPAFFRKPEDIETMFKAVHGWEHVQQALDKHEG|||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||| a505MRQAGMNPDPKTVKAVFAETAKGGLELAPAFFRKPEDIETMFKAVHGWEHVQQALDKHEG        70        80        90       100       110       120       130       140       150       160       170       180 m505.pepLLFITPHIGSYDLGGRYISQQLPFPLTAMYKPPKIKAIDKIMQAGRVRGKGKTAPTSIQG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a505LLFITPHIGSYDLGGRYISQQLPFPLTAMYKPPKIKAIDKIMQAGRVRGKGKTAPTSIQG       130       140       150       160       170       180       190       200       210       220       230       240 m505.pepVKQIIKALRSGEATIVLPDHVPSPQEGGEGVWVDFFGKPAYTMTLAAXLAHVKGVKTLFF||||||||||||||||||||||||||||||||||||||||||||||| |||||||||||| a505VKQIIKALRSGEATIVLPDHVPSPQEGGEGVWVDFFGKPAYTMTLAAKLAHVKGVKTLFF       190       200       210       220       230       240       250       260       270       280 m505.pepCCERLPGGQGFDLHIRPVQGELNGDKAHDAAVFNRNAEYWIRRFPTHI||||||||||||||||||||||||||||||||||||||||||||||: a505CCERLPGGQGFDLHIRPVQGELNGDKAHDAAVFNRNAEYWIRRFPTQYLFMYNRYKMPX       250       260       270       280       290The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1373>:

m505-1.seq 1 ATGTTTCGTT TACAATTCAG GCTGTTTCCC CCTTTGCGAA CCGCCATGCA 51CATCCTGTTG ACCGCCCTGC TCAAATGCCT CTCCCTGCTG CCGCTTTCCT 101 GTCTGCACACGCTGGGAAAC CGGCTCGGAC ATCTGGCGTT TTACCTTTTA 151 AAGGAAGACC GCGCGCGCATCGTCGCCAAT ATGCGGCAGG CGGGTTTGAA 201 CCCCGACCCC AAAACGGTCA AAGCCGTTTTTGCGGAAACG GCAAAAGGCG 251 GTTTGGAACT TGCCCCCGCG TTTTTCAGAA AACCGGAAGACATAGAAACA 301 ATGTTCAAAG CGGTACACGG CTGGGAACAT GTGCAGCAGG CTTTGGACAA351 ACACGAAGGG CTGCTATTCA TCACGCCGCA CATCGGCAGC TACGATTTGG 401GCGGACGCTA CATCAGCCAG CAGCTTCCGT TCCCGCTGAC CGCCATGTAC 451 AAACCGCCGAAAATCAAAGC GATAGACAAA ATCATGCAGG CGGGCAGGGT 501 TCGCGGCAAA GGAAAAACCGCGCCTACCAG CATACAAGGG GTCAAACAAA 551 TCATCAAAGC CCTGCGTTCG GGCGAAGCAACCATCGTCCT GCCCGACCAC 601 GTCCCCTCCC CTCAAGAAGG CGGGGAAGGC GTATGGGTGGATTTCTTCGG 651 CAAACCTGCC TATACCATGA CGCTGGCGGC AAAATTGGCA CACGTCAAAG701 GCGTGAAAAC CCTGTTTTTC TGCTGCGAAC GCCTGCCTGG CGGACAAGGT 751TTCGATTTGC ACATCCGCCC CGTCCAAGGG GAATTGAACG GCGACAAAGC 801 CCATGATGCCGCCGTGTTCA ACCGCAATGC CGAATATTGG ATACGCCGTT 851 TTCCGACGCA GTATCTGTTTATGTACAACC GCTACAAAAT GCCGTAAThis corresponds to the amino acid sequence <SEQ ID 1374; ORF 505-1>:

m505-1.pep 1 MFRLQFRLFP PLRTAMHILL TALLKCLSLL PLSCLHTLGN RLGHLAFYLL 51KEDRARIVAN MRQAGLNPDP KTVKAVFAET AKGGLELAPA FFRKPEDIET 101 MFKAVHGWEHVQQALDKHEG LLFITPHIGS YDLGGRYISQ QLPFPLTAMY 151 KPPKIKAIDK IMQAGRVRGKGKTAPTSIQG VKQIIKALRS GEATIVLPDH 201 VPSPQEGGEG VWVDFFGKPA YTMTLAAKLAHVKGVKTLFF CCERLPGGQG 251 FDLHIRPVQG ELNGDKAHDA AVFNRNAEYW IRRFPTQYLFMYNRYKMP* m505-1/g505 94.3% identity in 298 aa overlap          10        20        30        40        50        60m505-1.pep  MFRLQFRLFPPLRTAMHILLTALLKCLSLLPLSCLHTLGNRLGHLAFYLLKEDRARIVAN  |||||||||||||||||||||||||||||| ||||||||||||||||||||||||||||| g505  MFRLQFRLFPPLRTAMHILLTALLKCLSLLSLSCLHTLGNRLGHLAFYLLKEDRARIVAN          10        20        30        40        50        60          70        80        90       100       110       120m505-1.pep  MRQAGLNPDPKTVKAVFAETAKGGLELAPAFFRKPEDIETMFKAVHGWEHVQQALDKHEG  ||||||||| :||||||||||| |||||||||:|||||||||||||||||||||||| || g505  MRQAGLNPDTQTVKAVFAETAKCGLELAPAFFKKPEDIETMFKAVHGWEHVQQALDKGEG          70        80        90       100       110       120         130       140       150       160       170       180m505-1.pep  LLFITPHIGSYDLGGRYISQQLPFPLTAMYKPPKIKAIDKIMQAGRVRGKGKTAPTSIQG  |||||||||||||||||||||||| |||||||||||||||||||||||||||||||:||| g505  LLFITPHIGSYDLGGRYISQQLPFHLTAMYKPPKIKAIDKIMQAGRVRGKGKTAPTGIQG         130       140       150       160       170       180         190       200       210       220       230       240m505-1.pep  VKQIIKALRSGEATIVLPDHVPSPQEGGEGVWVDFFGKPAYTMTLAAKLAHVKGVKTLFF  |||||||||:|||||:|||||||||||| |||:||||||||||||||||||||||||||| g505  VKQIIKALRAGEATIILPDHVPSPQEGG-GVWADFFGKPAYTMTLAAKLAHVKGVKTLFF         190       200       210       220       230         250       260       270       280       290      299 m505-1.pep  CCERLPGGQGFDLHIRPVQGELNGDKAHDAAVFNRNAEYWIRRFPTQYLFMYNRYKMPX  |||||| |||| ||||||||||||:|||||||||||:||||||||||||||||||| || g505  CCERLPDGQGFVLHIRPVQGELNGNKAHDAAVFNRNTEYWIRRFPTQYLFMYNRYKTPX240       250       260       270       280       290 m505-1/a505 99.7%identity in 298 aa overlap          10        20        30        40        50        60m505-1.pep  MFRLQFRLFPPLRTAMHILLTALLKCLSLLPLSCLHTLGNRLGHLAFYLLKEDRARIVAN  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a505  MFRLQFRLFPPLRTAMHILLTALLKCLSLLPLSCLHTLGNRLGHLAFYLLKEDRARIVAN          10        20        30        40        50        60          70        80        90       100       110       120m505-1.pep  MRQAGLNPDPKTVKAVFAETAKGGLELAPAFFRKPEDIETMFKAVHGWEHVQQALDKHEG  |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||| a505  MRQAGMNPDPKTVKAVFAETAKGGLELAPAFFRKPEDIETMFKAVHGWEHVQQALDKHEG          70        80        90       100       110       120         130       140       150       160       170       180m505-1.pep  LLFITPHIGSYDLGGRYISQQLPFPLTAMYKPPKIKAIDKIMQAGRVRGKGKTAPTSIQG  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a505  LLFITPHIGSYDLGGRYISQQLPFPLTAMYKPPKIKAIDKIMQAGRVRGKGKTAPTSIQG         130       140       150       160       170       180         190       200       210       220       230       240m505-1.pep  VKQIIKALRSGEATIVLPDHVPSPQEGGEGVWVDFFGKPAYTMTLAAKLAHVKGVKTLFF  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a505  VKQIIKALRSGEATIVLPDHVPSPQEGGEGVWVDFFGKPAYTMTLAAKLAHVKGVKTLFF         190       200       210       220       230       240         250       260       270       280       290      299 m505-1.pep  CCERLPGGQGFDLHIRPVQGELNGDKAHDAAVFNRNAEYWIRRFPTQYLFMYNRYKMPX  ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a505  CCERLPGGQGFDLHIRPVQGELNGDKAHDAAVFNRNAEYWIRRFPTQYLFMYNRYKMPX         250       260       270       280       290The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1375>:

g506.seq 1 ATGGCGGTAT TTGATGAAGT CGGGCGCATC GCCCATGGCT GCGGCGGTGT 51TGTCAAACAA AGCCTGTTTC TGCGCGTCGT TCATCAGGTT GAACAAGGCG 101 CGCGGTTGGCTGAAGTAGTC GTCATCGTCT TGGCGGTAGT CCCAGTGTGC 151 CGCGTCGCCG TTGATTTTCAAAGGCGGTTC GGCGAAGTCG GGTTGTTGCT 201 GCCATTGGCC GAAGCTGTTG GGTTCGTAGTGCGGCAGGCT GCCGTAGTTG 251 CCGTCGGCGC GGCCTTGTCC GTCGCGCTGG TTGCTGTGAACAGGGCAACG 301 CGGACGATTG ACGGGGATTT GGCGGAAGTT CACACCCAAG CGGTAACGTT351 GCGCGTCGGC GTAATTGAAC AAACGGGCTT GCAACATTTT ATCCGGGCTC 401GCGCCGATAC CGGGAACGAG GTTGCTCGGT GCGAAGGCGG ATTGTTCCAC 451 ATCGGCGAAGAAGTTTTCGG GATTGCGGTT CAACTCGAAT TTGCCGACTT 501 CAATCAGCGG ATAGTCTTTTTTCGGCCAAA CTTTGGTCAA GTCAAACGGA 551 TGATAAGGCA CTTTTTCGGC ATCGGCTTCAGGCATGACTT GGATGTACAT 601 CGTCCATTTC GGGAACTCGC CGCGCTCGAT GGCTTCGTACAGGTCGCGCT 651 GATGGCTTTC GCGGTCGTCG GCGATGATTT TTGCAGCTTC TTCGTTGGTC701 AGGTTTTTAA TCCCTTGCTG GCTGCGGAAA TGGAATTTCA CCCAAAAACG 751TTCGCCCGCT TCGTTCCAGA AGCTGTAGGT ATGCGAACCG AAGCCGTGCA 801 TATGGCGGTAGCTGGCGGGA ATACCGCGGT CGCTCATCAC GATGGTAACT 851 TGGTGCAGGG CTTCGGGCAGCAGCGTCCAG AAGTCCCAGT TGTTTGTGGC 901 GGAACGCATA TTGGTGCGCG GATCGCGTTTGACGGCTTTG TTCAGGTCGG 951 GGAATTTGCG CGGGTCGCGC AGGAAGAACA CGGGCGTGTTGTTGCCGACC 1001 ACATCCCAGT TGCCTTCTTC GGTATAGAAT TTCAACGCAA AACCGCGGAT1051 GTCGCGTTCC GCATCGGCTG CGCCGCGCTC GCCTGCCACG GTGGTGAAAC 1101GGGCGAACAT CTCGGTTTTT TTGCCGACTT CGCTGAAAAT TTTGGCGCGG 1151 GTGTATTTGGTGATGTCGTG TGTTACGGTA AACGTACCGA ACGCGCCCGA 1201 ACCTTTGGCG TGCATACGGCGTTCGGGGAT GACTTCGCGC ACGAAGTCGG 1251 CGAGTTTTTC ATTCAGCCAC AAATCTTGCGTCAGCAGGGG GCCGCGCGGG 1301 CCGGCGGTCA GGCTGTTTTG ATTGTCGGCA ACGGGCGCGCCGTTGTTCAT 1351 GGTCAGATGG GTTACGGGGC ATTTGGAGGT AGTCATCGCT CTTGTTCCTT1401 TTCTCAGGTT GGTCAAATGG GGGGCAAACG GCTTACAGTA CGATTTGGCG 1451GAAAGCGTAT TCGTAACCGG TTTCTTGATT GTAATAAATT TCTTGAATCG 1501 ACATTTTATTTTCCTTTTGC AAAAACTATG GATGCGATTA TACGCCAAGA 1551 TTTTCGTTAT TAAThis corresponds to the amino acid sequence <SEQ ID 1376; ORF 506.ng>:

g506.pep 1 MAVFDEVGRI AHGCGGVVKQ SLFLRVVHQV EQGARLAEVV VIVLAVVPVC 51RVAVDFQRRF GEVGLLLPLA EAVGFVVRQA AVVAVGAALS VALVAVNRAT 101 RTIDGDLAEVHTQAVTLRVG VIEQTGLQHF IRARADTGNE VARCEGGLFH 151 IGEEVFGIAV QLEFAHFNQRIVFFRPNFGQ VKRMIRHFFG IGFRHDLDVH 201 RPFRELAALD GFVQVALMAF AVVGDDFCSFFVGQVFNPLL AAEMEFHPKT 251 FARFVPEAVG MRTEAVHMAV AGGNTAVAHH DGNLVQGFGQQRPEVPVVCG 301 GTHIGARIAF DGFVQVGEFA RVAQEEHGRV VADHIPVAFF GIEFQRKTAD351 VAFRIGCAAL ACHGGETGEH LGFFADFAEN FGAGVFGDVV CYGKRTERAR 401TFGVHTAFGD DFAHEVGEFF IQPQILRQQG AARAGGQAVL IVGNGRAVVH 451 GQMGYGAFGGSHRSCSFSQV GQMGGKRLTV RFGGKRIRNR FLDCNKFLES 501 TFYFPFAKTM DAIIRQDFRY *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1377>:

m506.seq 1 ATGGCGGTAT TTGATGAAGT CGGGCGCGTC GCCCATTGCG GCGGCGGTGT 51TGCCGAACAA TGCCTGTTTC TGCGCGTCGT TCATCAGGTT GAACAGGGCG 101 CGCGGTTGGCTGAAATAGTC GTCATCGTCT TGGCGGTAGT CCCAGTGTGC 151 CGCGTCGCCG TTGATTTTCAAAGGCGGTTC GGCGAAtCGg GGTTGTTGCT 201 GCCATTGGCC GAAGCTGTyG GGTTCGTAGTGCGGCAGGCT GCCGyAGTTG 251 CCGTCGGCGC GGCCTTGCCC GTyGCGsTgr TTgCTGTgAACAsGGCAACG 301 CGGACGATTG ACGGGAATTT GGCGGAAGTT TACGCCCAAA CGGTAGCGTT351 GTGCGTCGGC GTAATTGAAC AAACGCGCTT GCAGCATTTT ATCTsGGCTG 401GCGCCGACAC CGGGAACGAG GTTGCTCGGT GCGAAGGCGG ATTGTTCCAC 451 ATCGGCGAAGAAGTTTTCGG GATTGCGGTT CTCAAACGGA TGATAAGGTA 501 CTTTTTCCGC GTCTGCTTCAGGCATGACTT GGATGTACAT CGTCCATTTC 551 GGAAACTCGC CGCGTTCGAT GGCTTCsTATAAGTCGCGCT GATGGCTTTC 601 GCGGTCGTCG GCGATGATTT TGGCGGCTTC TTCGTTGGTCAGGTTTTTAA 651 TGCCTTGTTG GGTGCGGAAA TGGAATTTCA CCCAAAAACG CTCGCCTGCT701 TCGTTCCAGA AGCTGTAGGT ATGCGAACCG AAGCCGTGCA TATGGCGGTA 751GCCGGCGGGG ATGCCGCGGT CGCTCATCAC GATGGTAACT TGGTGCAGTG 801 CTTCGGGCAGCAGCGTCCAG AAGTCCCAGT TGTTTGTGGC AGAGCGCATA 851 TTGGTGCGCG GGTCGCGTTTGACGGCTTTG TTCAGGTCGG GGAACTTACG 901 CGGGTCGCGC AGGAAGAACA CGGGCGTGTTGTTGCCGACC ACATCCCAGT 951 TGCCTTCTTC GGTATAAAAT TTCAAGGCAA AACCGCGGATGTCGCGTTCT 1001 GCATCGGCTG CGCCGCGTTC GCCTGCCACG GTGGTGAAAC GGGCGAACAT1051 CTCGGTTTTT TTGCCGACTT CGCTGAAGAT TCCTTTGGCG TGCATACGGC 1101GTTCGGGGAT GACTTCGCGC ACGAAGTCGG CGAGTTTTTC AGTCATCGCT 1151 CTTGTTCCTTTTCTCAGGTT GGTCAAATGG GGGTAAACGG CTTACAGTAC 1201 GATTTGGCGG AAAGCGTATTCGTAACCGGT TTCTTGATTG CAATAAATTT 1251 CTTGAATCGA CATTTTATTT CCCTTTTGTAAAAACTATGG ATGCGACTAT 1301 ACGCCAAGAT TTTCGCTATT AAThis corresponds to the amino acid sequence <SEQ ID 1378; ORF 506>:

m506.pep 1 MAVFDEVGRV AHCGGGVAEQ CLFLRVVHQV EQGARLAEIV VIVLAVVPVC 51RVAVDFQRRF GESGLLLPLA EAVGFVVRQA AXVAVGAALP VAXXAVNXAT 101 RTIDGNLAEVYAQTVALCVG VIEQTRLQHF IXAGADTGNE VARCEGGLFH 151 IGEEVFGIAV QLEFAHFNQRIVFFRPNFGQ VKRMIRYFFR VCFRHDLDVH 201 RPFRKLAAFD GFXXVALMAF AVVGDDFGGFFVGQVFNALL GAEMEFHPKT 251 LACFVPEAVG MRTEAVHMAV AGGDAAVAHH DGNLVQCFGQQRPEVPVVCG 301 RAHIGARVAF DGFVQVGELT RVAQEEHGRV VADHIPVAFF GIKFQGKTAD351 VAFCIGCAAF ACHGGETGEH LGFFADFAED FGAGVFGDVV RYGKRTERAR 401TFGVHTAFGD DFAHEVGEFF IQPQILRQQR AARTGGQAVL IVGNRRAVVH 451 GQMGYRAFGGSHRSCSFSQV GQMGGKRLTV RFGGKRIRNR FLDCNKFLES 501 TFYFPFVKTM DATIRQDFRY *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 506 shows 89.2% identity over a 520 aa overlap with a predicted ORF(ORF 506.ng) from N. gonorrhoeae:

m506/g506         10        20        30        40        50        60m506.pep MAVFDEVGRVAHCGGGVAEQCLFLRVVHQVEQGARLAEIVVIVLAVVPVCRVAVDFQRRF|||||||||:||  |||::| |||||||||||||||||:||||||||||||||||||||| g506MAVFDEVGRIAHGCGGVVKQSLFLRVVHQVEQGARLAEVVVIVLAVVPVCRVAVDFQRRF        10        20        30        40        50        60        70        80        90       100       110       120 m506.pepGESGLLLPLAEAVGFVVRQAAXVAVGAALPVAXXAVNXATRTIDGNLAEVYAQTVALCVG|| |||||||||||||||||| ||||||| ||  ||| |||||||:||||::|:|:| || g506GEVGLLLPLAEAVGFVVRQAAVVAVGAALSVALVAVNRATRTIDGDLAEVHTQAVTLRVG        70        80        90       100       110       120       130       140       150       160       170       180 m506.pepVIEQTRLQHFIXAGADTGNEVARCEGGLFHIGEEVFGIAVQLEFAHFNQRIVFFRPNFGQ||||| ||||| | |||||||||||||||||||||||||||||||||||||||||||||| g506VIEQTGLQHFIRARADTGNEVARCEGGLFHIGEEVFGIAVQLEFAHFNQRIVFFRPNFGQ       130       140       150       160       170       180       190       200       210       220       230       240 m506.pepVKRMIRYFFRVCFRHDLDVHRPFRKLAAFDGFXXVALMAFAVVGDDFGGFFVGQVFNALL ||||||:|| :||||||||||||:|||:|||  ||||||||||||| :|||||||| || g506VKRMIRHFFGIGFRHDLDVHRPFRELAALDGFVQVALMAFAVVGDDFCSFFVGQVFNPLL       190       200       210       220       230       240       250       260       270       280       290       300 m506.pepGAEMEFHPKTLACFVPEAVGMRTEAVHMAVAGGDAAVAHHDGNLVQCFGQQRPEVPVVCG:|||||||||:| ||||||||||||||||||||::||||||||||| ||||||||||||| g506AAEMEFHPKTFARFVPEAVGMRTEAVHMAVAGGNTAVAHHDGNLVQGFGQQRPEVPVVCG       250       260       270       280       290       300       310       320       330       340       350       360 m506.pepRAHIGARVAFDGFVQVGELTRVAQEEHGRVVADHIPVAFFGIKFQGKTADVAFCIGCAAF :|||||:||||||||||::||||||||||||||||||||||:|| ||||||| |||||: g506GTHIGARIAFDGFVQVGEFARVAQEEHGRVVADHIPVAFFGIEFQRKTADVAFRIGCAAL       310       320       330       340       350       360       370       380       390       400       410       420 m506.pepACHGGETGEHLGFFADFAEDFGAGVFGDVVRYGKRTERARTFGVHTAFGDDFAHEVGEFF|||||||||||||||||||:|||||||||| ||||||||||||||||||||||||||||| g506ACHGGETGEHLGFFADFAENFGAGVFGDVVCYGKRTERARTFGVHTAFGDDFAHEVGEFF       370       380       390       400       410       420       430       440       450       460       470       480 m506.pepIQPQILRQQRAARTGGQAVLIVGNRRAVVHGQMGYRAFGGSHRSCSFSQVGQMGGKRLTV||||||||| |||:|||||||||| |||||||||| |||||||||||||||||||||||| g506IQPQILRQQGAARAGGQAVLIVGNGRAVVHGQMGYGAFGGSHRSCSFSQVGQMGGKRLTV       430       440       450       460       470       480       490       500       510       520 m506.pepRFGGKRIRNRFLDCNKFLESTFYFPFVKTMDATIRQDFRY||||||||||||||||||||||||||:||||| ||||||| g506RFGGKRIRNRFLDCNKFLESTFYFPFAKTMDAIIRQDFRY       490       500       510       520The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1379>:

a506.seq 1 ATGGCGGTAT TTGATGAAGT CGGGCGCGTC GCCCATTGCG GCGGCGGTGT 51TGCCGAACAA TGCCTGTTTC TGCGCGTCGT TCATCAGGTT GAACAGGGCG 101 CGCGGTTGGCTGAAATAGTC GTCATCGTCT TGGCGGTAGT CCCAGTGCGC 151 CGCGTCGCCG TTGATTTTCAAAGGCGGTTC GGCGAAGTCG GGCTGCTGCT 201 GCCATTGGCC GAAGCTGTTG GGTTCGTAGTGCGGCAGGCT GCCGTAGTTG 251 CCGTCGGCGC GTCCTTGTCC GTCGCGCTGG TTGCTGTGAACAGGGCAACG 301 CGGACGGTTG ACAGGGATTT GGCGGAAGTT CACGCCCAAG CGGTAGCGTT351 GCGCGTCGGC GTAATTGAAC AAACGCGCCT GCAACATTTT ATCTGGGCTG 401GCGCCGACAC CGGGAACGAG GTTGCTCGGT GCGAAGGCGG ATTGTTCCAC 451 ATCGGCGAAGAAGTTTTCGG GATTGCGGTT CAACTCGAAT TCGCCCACTT 501 CAATCAGCGG ATAGTCTTTTTTCGGCCAAA CTTTGGTCAA GTCAAACGGA 551 TGATACGGCA CTTTTTCCGC ATCGGCTTCAGGCATGACTT GGATGTACAT 601 CGTCCATTTC GGAAACTCGC CGCGCTCGAT GGCTTCGTACAGGTCGCGCT 651 GATGGCTTTC ACGGTCGTCG GCGATGATTT TGGCGGCTTC TTCGTTGGTC701 AGGTTTTTAA TGCCTTGTTG GGTGCGGAAA TGGAATTTCA CCCAAAAACG 751CTCGCCTGCT TCGTTCCAGA AGCTGTAGGT ATGCGAACCG AAGCCGTGCA 801 TATGGCGGTAGCCGGCGGGG ATGCCGCGGT CGCTCATCAC GATGGTAACT 851 TGGTGCAGTG CTTCGGGCAGCAGCGTCCAG AAGTCCCAGT TGTTTGTGGC 901 AGAGCGCATA TTGGTGCGCG GGTCGCGTTTGACGGCTTTG TTCAGGTCGG 951 GGAACTTACG CGGGTCGCGC AGGAAGAACA CGGGCGTGTTGTTGCCGACC 1001 ACATCCCAGT TGCCTTCTTC GGTATAGAAC TTCAACGCAA AACCGCGGAT1051 GTCGCGTTCT GCATCGGCTG CGCCGCGTTC GCCTGCCACG GTGGTGAAAC 1101GGGCGAACAT CTCGGTTTTT TTGCCGACTT CGCTGAAGAT TTTGGCGCGG 1151 GTGTATTTGGTGATGTCGTG CGTTACGGTA AACGTACCGA ACGCGCCCGA 1201 ACCTTTGGCG TGCATACGGCGTTCGGGGAT GACTTCGCGC ACGAAGTCGG 1251 CGAGTTTTTC ATTCAGCCAC AAATCCTGCGCCAGCAGAGG GCCGCGAGGA 1301 CCGGCGGTCA GGCTGTTTTG ATTGTCGGCA ACAGGCGCGCCGTTGTTCAT 1351 GGTCAGATGG GTTACAGGGC ATTTGGAGGT ANTCATCGCT CTTGTTCCTT1401 TTCTCAGGTT GGTCAAAT.G GGGGTAAACG GCTTACAGTA CGATTTGGCG 1451GAAAGCGTAT TCGTAACCGG TTTCTTGATT GCAATAAATT TCTTGAATCG 1501 ACATTTTATTTCCCTTTTGT AAAAACTATG GATGCGACTA TACGCCAAGA 1551 TTTTCGCTAT TAAThis corresponds to the amino acid sequence <SEQ ID 1380; ORF 506.a>:

a506.pep 1 MAVFDEVGRV AHCGGGVAEQ CLFLRVVHQV EQGARLAEIV VIVLAVVPVR 51RVAVDFQRRF GEVGLLLPLA EAVGFVVRQA AVVAVGASLS VALVAVNRAT 101 RTVDRDLAEVHAQAVALRVG VIEQTRLQHF IWAGADTGNE VARCEGGLFH 151 IGEEVFGIAV QLEFAHFNQRIVFFRPNFGQ VKRMIRHFFR IGFRHDLDVH 201 RPFRKLAALD GFVQVALMAF TVVGDDFGGFFVGQVFNALL GAEMEFHPKT 251 LACFVPEAVG MRTEAVHMAV AGGDAAVAHH DGNLVQCFGQQRPEVPVVCG 301 RAHIGARVAF DGFVQVGELT RVAQEEHGRV VADHIPVAFF GIELQRKTAD351 VAFCIGCAAF ACHGGETGEH LGFFADFAED FGAGVFGDVV RYGKRTERAR 401TFGVHTAFGD DFAHEVGEFF IQPQILRQQR AARTGGQAVL IVGNRRAVVH 451 GQMGYRAFGGXHRSCSFSQV GQXGGKRLTV RFGGKRIRNR FLDCNKFLES 501 TFYFPFVKTM DATIRQDFRY *m506/a506 94.8% identity in 520 aa overlap        10        20        30        40        50        60 m506.pepMAVFDEVGRVAHCGGGVAEQCLFLRVVHQVEQGARLAEIVVIVLAVVPVCRVAVDFQRRF||||||||||||||||||||||||||||||||||||||||||||||||| |||||||||| a506MAVFDEVGRVAHCGGGVAEQCLFLRVVHQVEQGARLAEIVVIVLAVVPVRRVAVDFQRRF        10        20        30        40        50        60        70        80        90       100       110       120 m506.pepGESGLLLPLAEAVGFVVRQAAXVAVGAALPVAXXAVNXATRTIDGNLAEVYAQTVALCVG|| |||||||||||||||||| |||||:| ||  ||| ||||:| :||||:||:||| || a506GEVGLLLPLAEAVGFVVRQAAVVAVGASLSVALVAVNRATRTVDRDLAEVHAQAVALRVG        70        80        90       100       110       120       130       140       150       160       170       180 m506.pepVIEQTRLQHFIXAGADTGNEVARCEGGLFHIGEEVFGIAVQLEFAHFNQRIVFFRPNFGQ||||||||||| |||||||||||||||||||||||||||||||||||||||||||||||| a506VIEQTRLQHFIWAGADTGNEVARCEGGLFHIGEEVFGIAVQLEFAHFNQRIVFFRPNFGQ       130       140       150       160       170       180       190       200       210       220       230       240 m506.pepVKRMIRYFFRVCFRHDLDVHRPFRKLAAFDGFXXVALMAFAVVGDDFGGFFVGQVFNALL ||||||:|||:||||||||||||||||:|||  ||||||:||||||||||||||||||| a506VKRMIRHFFRIGFRHDLDVHRPFRKLAALDGFVQVALMAFTVVGDDFGGFFVGQVFNALL       190       200       210       220       230       240       250       260       270       280       290       300 m506.pepGAEMEFHPKTLACFVPEAVGMRTEAVHMAVAGGDAAVAHHDGNLVQCFGQQRPEVPVVCG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a506GAEMEFHPKTLACFVPEAVGMRTEAVHMAVAGGDAAVAHHDGNLVQCFGQQRPEVPVVCG       250       260       270       280       290       300       310       320       330       340       350       360 m506.pepRAHIGARVAFDGFVQVGELTRVAQEEHGRVVADHIPVAFFGIKFQGKTADVAFCIGCAAF||||||||||||||||||||||||||||||||||||||||||::| |||||||||||||| a506RAHIGARVAFDGFVQVGELTRVAQEEHGRVVADHIPVAFFGIELQRKTADVAFCIGCAAF       310       320       330       340       350       360       370       380       390       400       410       420 m506.pepACHGGETGEHLGFFADFAEDFGAGVFGDVVRYGKRTERARTFGVHTAFGDDFAHEVGEFF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a506ACHGGETGEHLGFFADFAEDFGAGVFGDVVRYGKRTERARTFGVHTAFGDDFAHEVGEFF       370       380       390       400       410       420       430       440       450       460       470       480 m506.pepIQPQILRQQRAARTGGQAVLIVGNRRAVVHGQMGYRAFGGSHRSCSFSQVGQMGGKRLTV|||||||||||||||||||||||||||||||||||||||| ||||||||||| ||||||| a506IQPQILRQQRAARTGGQAVLIVGNRRAVVHGQMGYRAFGGXHRSCSFSQVGQXGGKRLTV       430       440       450       460       470       480       490       500       510       520 m506.pepRFGGKRIRNRFLDCNKFLESTFYFPFVKTMDATIRQDFRYX||||||||||||||||||||||||||||||||||||||||| a506RFGGKRIRNRFLDCNKFLESTFYFPFVKTMDATIRQDFRYX       490       500       510       520The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1381>:

g507.seq 1 ATGCTCTTGC CGGCTTTGCA ACAAGGCGGC GGCTTCCTGA GCGGCGGCGG 51TTTCGGCCTC GTCGGGCAGG TTCAGGGCTT GGTTTTCCTG CTTCAGACGG 101 CCTTTGCGCTCTTCGTGCTT GGCAACGGTT TGTTCGGCAT GGGCAAGCTG 151 CTGCTGCTTC AACGCCAGTTCGCGGCGGAT GCGGTTTGCC TCGTCCTGCT 201 GGGTTTGGAA GGCAGCGTTG AGCGTGGCTTGGACTTCTTC CAATTCGGGC 251 AGACGCTCTT CGTGTTCGGC AACCTGCATC GCCCATTCCGCCAATTCGGT 301 TTGCTTTTCT TCGACCTGCA ACTCGTTTTC CTCAAGCTGC ACGCGGATTT351 GCTGCTGCTC CTGCCGGATG CGTTGCAACT GCGCCTGCGC TGCCTGCTTG 401TCGCGTTCGA TGCGTTGGTG CAGGTTTTGC CGGTGGCGGA TTTGTTCTTC 451 CAAACGGGCAATCTGCTCGC GCAACACGCC GCGTTTGTTG CTCAATTCGT 501 GTACTGCCTG CTGCTGCGACTGTTCGGCAG TCTGCAAGGC GTGTACTTCG 551 TTATTTAAThis corresponds to the amino acid sequence <SEQ ID 1382; ORF 507.ng>:

g507.pep 1 MLLPALQQGG GFLSGGGFGL VGQVQGLVFL LQTAFALFVL GNGLFGMGKL 51LLLQRQFAAD AVCLVLLGLE GSVERGLDFF QFGQTLFVFG NLHRPFRQFG 101LLFFDLQLVF LKLHADLLLL LPDALQLRLR CLLVAFDALV QVLPVADLFF 151QTGNLLAQHA AFVACFVYCL LLRLFGSLQG VYFVI*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1383>:

m507.seq 1 ATGCTCTTGC TGACTTTGCA ACAAGGCGGC TGCTTCCTGC GCGGCGGCGG 51TTTCGGCTTC GTCGGGCAGG TTTAAGGCTT GGTTTTCCTG TTTCAGACGA 101 CCTTTGCGCTCTTCGTGCTT GGCAATCGTT TGTTCGGCAT GGGCAAGCTG 151 CTGCTGCTTC AACGCCAGTTCGCGGCGGAT GCGGTTTGCC TCGTCCTGCT 201 GGGTTTGGAA GGCGGCGTTG AGCGTGGCTTGGGCTTCTTC CAATTCGGGC 251 AGACGCTCCT CGTGTTCGGC AACCTGCATC GCCCATTCCGCCAGCTCGGT 301 TTGTTTTTCT TCGACCTGCA ACTCGTTTTC TTCAAGCTGC ACGCGGATTT351 GCTGCTGCTC TTGATGAATG CGTTGTAACT GCGCCTGCGC TGCCTGCTTG 401TCGCGTTCGA TGCGTTGGTG CAGGTTTTGC TGATGGCGGA TTTGTTCTTC 451 CAAACGGGCAATCTGCTCGC GCAACACGCC GCGCTTGTTG CTCAATTCAT 501 GCACTGCCTG CTGCTGCGACTGTTCGGCAG TCTGCAAGGC GTGTACTTCG 551 TCGTTTAAThis corresponds to the amino acid sequence <SEQ ID 1384; ORF 507>:

m507.pep 1 MLLLTLQQGG CFLRGGGFGF VGQVXGLVFL FQTTFALFVL GNRLFGMGKL 51LLLQRQFAAD AVCLVLLGLE GGVERGLGFF QFGQTLLVFG NLHRPFRQLG 101LFFFDLQLVF FKLHADLLLL LMNALXLRLR CLLVAFDALV QVLLMADLFF 151QTGNLLAQHA ALVAQFMHCL LLRLFGSLQG VYFVV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 507 shows 87.0% identity over a 185 aa overlap with a predicted ORF(ORF 507.ng) from N. gonorrhoeae:

m507/g507         10        20        30        40        50        60m507.pep MLLLTLQQGGCFLRGGGFGFVGQVXGLVFLFQTTFALFVLGNRLFGMGKLLLLQRQFAAD||| :||||| || |||||:|||| |||||:||:|||||||| ||||||||||||||||| g507MLLPALQQGGGFLSGGGFGLVGQVQGLVFLLQTAFALFVLGNGLFGMGKLLLLQRQFAAD        10        20        30        40        50        60        70        80        90       100       110       120 m507.pepAVCLVLLGLEGGVERGLGFFQFGQTLLVFGNLHRPFRQLGLFFFDLQLVFFKLHADLLLL|||||||||||:||||| ||||||||:|||||||||||:||:||||||||:||||||||| g507AVCLVLLGLEGSVERGLDFFQFGQTLFVFGNLHRPFRQFGLLFFDLQLVFLKLHADLLLL        70        80        90       100       110       120       130       140       150       160       170       180 m507.pepLMNALXLRLRCLLVAFDALVQVLLMADLFFQTGNLLAQHAALVAQFMHCLLLRLFGSLQG| :|| ||||||||||||||||| :||||||||||||||||:||||::|||||||||||| g507LPDALQLRLRCLLVAFDALVQVLPVADLFFQTGNLLAQHAAFVAQFVYCLLLRLFGSLQG       130       140       150       160       170       180 m507.pepVYFVV ||||: g507 VYFVIThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1385>:

a507.seq 1 ATGCTCTTGC TGGCTTTGCA ACAAGGCGGC AGCTTCCTGC GCGGCGGCGG 51TTTCGGCTTC GTCAGGCAGA TTCAGGGCTT GGTTTTCCTG TTTCAGACGA 101 CCTTTGCGCTCTTCGTGCTT GGCAACGGTT TGTTCGGCAT GGGCAAGCTG 151 CTGCTGCTTC AACGCCAGTTCGCGGCGGAT GCGGTTTGCC TCGTCCTGCT 201 GGGTTTGGAA GGCGGCATTG AGTGTGGCTTGGGTTTCTTC CAATTCGGGC 251 AGACGCTCTT CGTGTTCGGC AACCTGCATC GCCCATTCCGCCAATTCGGT 301 TTGCTTTTCT TCCGCCTGCA ACTCGTTTTC TTCAAGCTGC ACGCGGATTT351 GCTGCTGCTC CTGATGGATG CGCTGCATCT GCGCCTGCGC CGCCTGCTTG 401TCGCGTTCGA TGCGTTGGTG CAGGTTTTGC TGATGGCGGA TTTGTTCTTC 451 CAAACGGGCAATCTGTTCGC GCAACACGCC GCGTTTGTTG CCCAATTCGT 501 GCACCGCCTG CTGCTGCGACTGTTCGGCAG TCTGCAAGGC GTGTACTTCG 551 TCGTTTAAThis corresponds to the amino acid sequence <SEQ ID 1386; ORF 507.a>:

a507.pep 1 MLLLALQQGG SFLRGGGFGF VRQIQGLVFL FQTTFALFVL GNGLFGMGKL 51LLLQRQFAAD AVCLVLLGLE GGIECGLGFF QFGQTLFVFG NLHRPFRQFG 101LLFFRLQLVF FKLHADLLLL LMDALHLRLR RLLVAFDALV QVLLMADLFF 151 QTGNLFAQHAAFVAQFVHRL LLRLFGSLQG VYFVV* m507/a507 89.7% identity in 185 aa overlap        10        20        30        40        50        60 m507.pepMLLLTLQQGGCFLRGGGFGFVGQVXGLVFLFQTTFALFVLGNRLFGMGKLLLLQRQFAAD||||:||||| |||||||||| |: ||||||||||||||||| ||||||||||||||||| a507MLLLALQQGGSFLRGGGFGFVRQIQGLVFLFQTTFALFVLGNGLFGMGKLLLLQRQFAAD        10        20        30        40        50        60        70        80        90       100       110       120 m507.pepAVCLVLLGLEGGVERGLGFFQFGQTLLVFGNLHRPFRQLGLFFFDLQLVFFKLHADLLLL||||||||||||:| |||||||||||:|||||||||||:||:|| ||||||||||||||| a507AVCLVLLGLEGGIECGLGFFQFGQTLFVFGNLHRPFRQFGLLFFRLQLVFFKLHADLLLL        70        80        90       100       110       120       130       140       150       160       170       180 m507.pepLMNALXLRLRCLLVAFDALVQVLLMADLFFQTGNLLAQHAALVAQFMHCLLLRLFGSLQG||:|| |||| ||||||||||||||||||||||||:|||||:||||:| ||||||||||| a507LMDALHLRLRRLLVAFDALVQVLLMADLFFQTGNLFAQHAAFVAQFVHRLLLRLFGSLQG       130       140       150       160       170       180 m507.pepVYFVVX |||||| a507 VYFVVXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1387>:

g508.seq 1 ATGGTAGCGT TTGGCGTTGA TCAGGGCCTC CTGCTGCTGC AACAGGGCGG 51TTTGGGTGGC GGCCTGAAGC TGCGGCAGCT TGGTTTGCAG GGTTTGTACG 101 CGGGCGTATTGCTCCCTGCC CTGTTCCTGA ATCTGCGCGA GTTTTTCCTG 151 CACGGCGATG TATTCTTCGTCCAGCGTGTG TACGGTTTCG GTCAACTCGT 201 CGAGCTTGAT GTGCTGCTCG TCGTTTTGGAACTCGGTTTC ATAGGCGAGG 251 GCAAGCTCTT GCCGGCGTTC CTGCCAGTCC AGGGTTTGCTGTTCGAGCCG 301 GGCGATTTGC TGCCGGTAGT TTTGTTTTTG CGGGTTGAGT TTGTGGACGG351 CGACTTCGGC AAGCCCGTAT TGGCGGTTGG CTTCCAACAG GGCAAGCTGC 401GCCTGTTTCA GACGGCCTTG CTGCTCTTGG CGGCTGTGCG CGGTGGTTTG 451 CTGCTGGTGTTCGAGTTCGG CGGCGGCTTC CTGCAAAGTA GCGATGTCGT 501 CTGAThis corresponds to the amino acid sequence <SEQ ID 1388; ORF 508.ng>:

g508.pep 1 MVAFGVDQGL LLLQQGGLGG GLKLRQLGLQ GLYAGVLLPA LFLNLREFFL 51HGDVFFVQRV YGFGQLVELD VLLVVLELGF IGEGKLLPAF LPVQGLLFEP 101 GDLLPVVLFLRVEFVDGDFG KPVLAVGFQQ GKLRLFQTAL LLLAAVRGGL 151 LLVFEFGGGF LQSSDVVThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1389>:

m508.seq 1 ATGGTAGCGT TTGGCGTTGA TCAGGGCTTC CTGCTGCTGC AACAAGGCGG 51TTTGGGTGGC GGCCTGAAGC TGCGGCAGCT TGGTTTGCAG GGTTTGCACT 101 TTAGCGTATTGCTCCCTGCC CTGTTCCTGA ATCTGCGCGA GTTTCTCTTG 151 CACAACAATA TATTCTTCGTCCAAGGTCTG TACGGCTTCG CTTAATTCTT 201 CAAGCTTGAT GTGCTGCTCG TCGTTTTGGAACTCGGTTTC ATAGGCGAGG 251 GCAAGCTCTT GCTGGCGTTC CTGCCAGTCG AGGGTTTGCTGTTCAAGCTG 301 GGCGATTTGC TGCCGGTAGT TTTGTTTTTG CTGGTTGAGT TTGTGGACGG351 CGACTTCGGC AAGCCCGTAT TGGCGGTTGG CTTCCAACAG GGCAAGCTGC 401GCCTGTTTCA GACGGCCTTG CTGCTCTTGG CGGCTGTGCG CGGTGGTTTG 451 CTGCTGGTGTTCGAGTTCGG CGGCGGCTTC CTGCAAGGTA ACGATGTCGT 501 CTGAThis corresponds to the amino acid sequence <SEQ ID 1390; ORF 508.ng>:

m508.pep 1 MVAFGVDQGF LLLQQGGLGG GLKLRQLGLQ GLHFSVLLPA LFLNLREFLL 51HNNIFFVQGL YGFAXFFKLD VLLVVLELGF IGEGKLLLAF LPVEGLLFKL 101 GDLLPVVLFLLVEFVDGDFG KPVLAVGFQQ GKLRLFQTAL LLLAAVRGGL 151 LLVFEFGGGF LQGNDVV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 508 shows 86.8% identity over a 167 aa overlap with a predicted ORF(ORF 508.ng) from N. gonorrhoeae:

m508/g508         10        20        30        40        50        60m508.pep MVAFGVDQGFLLLQQGGLGGGLKLRQLGLQGLHFSVLLPALFLNLREFLLHNNIFFVQGL|||||||||:||||||||||||||||||||||: :|||||||||||||:||:::|||| : g508MVAFGVDQGLLLLQQGGLGGGLKLRQLGLQGLYAGVLLPALFLNLREFFLHGDVFFVQRV        10        20        30        40        50        60        70        80        90       100       110       120 m508.pepYGFAXFFKLDVLLVVLELGFIGEGKLLLAFLPVEGLLFKLGDLLPVVLFLLVEFVDGDFG |||: ::||||||||||||||||||| |||||:||||: |||||||||| ||||||||| g508YGFGQLVELDVLLVVLELGFIGEGKLLPAFLPVQGLLFEPGDLLPVVLFLRVEFVDGDFG        70        80        90       100       110       120       130       140       150       160 m508.pepKPVLAVGFQQGKLRLFQTALLLLAAVRGGLLLVFEFGGGFLQGNDVV||||||||||||||||||||||||||||||||||||||||||::||| g508KPVLAVGFQQGKLRLFQTALLLLAAVRGGLLLVFEFGGGFLQSSDVV       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1391>:

a508.seq 1 ATGGTAGCGT TTGGCGTTGA TCAGGGCTTC CTGCTGCTGC AACAGGGCGG 51TTTGGGTGGC GGCCTGAAGC TGCGGCAGCT TGGTTTGCAG GGTTTGTACG 101 CGGGCGTATTGTTCCCTACC CTGCTCCTGA ATCTGCGCGA GTTTCTCCTG 151 TACGACAATA TATTCTTCGTCCAAACTCTG TACGGCTTCG CTCAACTCTT 201 CGAGCTTGAT GTGCTGCTCG TCGTTTTGGAACTCGGTTTC ATAGGCGAGG 251 GCAAGCTCTT GCTGGCGTTC CTGCCAATCG AAGGTTTGTTGTTCAAGCTG 301 GGCAATTTGC TGTTGGTAGT TTTGTTTTTG CTGGTTGAGC TTGTGGACGG351 CGACTTCGGC AAGCCCGTAT TGGCGGTTGG CTTCCAACAG GGCAAGCTGC 401GCCTGTTTCA GACGACCTTG CTGCTCTTGG CGGCTGTGCG CGGCGGTTTG 451 CTGCTGGTGTTCGAGTTCGG CGGCGGCTTC CTGCAAAATG GCGATGTCGT 501 CTGAThis corresponds to the amino acid sequence <SEQ ID 1392; ORF 508.a>:

a508.pep 1 MVAFGVDQGF LLLQQGGLGG GLKLRQLGLQ GLYAGVLFPT LLLNLREFLL 51YDNIFFVQTL YGFAQLFELD VLLVVLELGF IGEGKLLLAF LPIEGLLFKL 101GNLLLVVLFL LVELVDGDFG KPVLAVGFQQ GKLRLFQTTL LLLAAVRGGL 151 LLVFEFGGGFLQNGDVV* m508/a508 88.6% identity in 167 aa overlap        10        20        30        40        50        60 m508.pepMVAFGVDQGFLLLQQGGLGGGLKLRQLGLQGLHFSVLLPALFLNLREFLLHNNIFFVQGL||||||||||||||||||||||||||||||||: :||:|:|:||||||||::|||||| | a508MVAFGVDQGFLLLQQGGLGGGLKLRQLGLQGLYAGVLFPTLLLNLREFLLYDNIFFVQTL        10        20        30        40        50        60        70        80        90       100       110       120 m508.pepYGFAXFFKLDVLLVVLELGFIGEGKLLLAFLPVEGLLFKLGDLLPVVLFLLVEFVDGDFG|||| :|:||||||||||||||||||||||||:||||||||:|| ||||||||:|||||| a508YGFAQLFELDVLLVVLELGFIGEGKLLLAFLPIEGLLFKLGNLLLVVLFLLVELVDGDFG        70        80        90       100       110       120       130       140       150       160 m508.pepKPVLAVGFQQGKLRLFQTALLLLAAVRGGLLLVFEFGGGFLQGNDVVX||||||||||||||||||:|||||||||||||||||||||||::|||| a508KPVLAVGFQQGKLRLFQTTLLLLAAVRGGLLLVFEFGGGFLQNGDVVX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1393>:

g509.seq 1 atggtcgctg tatgtgatga acgggctgta cagcggacgt tggtggccca 51attcgcgcaa caaggcggct tgtttttgct cttcgttcag gctgttgtag 101 tcttccaagcctgcgtgttg gaaaagctcg gcaaccacat cggcgtgttt 151 gcctgcgtgt tggcgcaggtcgagcggcat catgtggaag ccgaacacgg 201 acacggaacg gatgaggtct gccaaacggccttcggcaag caggcggctg 251 ccgttgtcga taagggaacg ttgcaatttt ttcaaatcatcgagaaattt 301 ttgggccgaa gcataaggct cgagaaagcc gaatttgcag cccatgccca351 aaccgagcga gcgcgctttg cccatagcgc gcgccataat gtaggcaatg 401gcgcggcggt aaggttcttc ggtgcgggcg atttcttcgt caggcgagag 451 ggctgccagtgccattacgt cgtcgttgac tttgacgcgg cggatggaaa 501 gcggcagttc gcggtaaagtttgtcgagtt cgctgcggta aaaacggaac 551 acggcatcgg cgtggcggcg gaaggcaaagcgcagggttt cgccagaaac 601 aaacggattg ccgtcgcggt cgccgccgat ccagccgccgattttaagga 651 tattcggaac gcggacatcg ggataggccg tctgaaagtc gtgttccatc701 ttgcggtaga gtttgggcag ggcttcaaaa aagctcatcg ggaagatgga 751cacgccgttg ttgatttcgt cgttgacgct gagtttgtgg cggcgcgttt 801 cgctggtctgccacaagccc agaagcacgg tgtcgatttc gcggcgcagc 851 cgtgccagcg cgtcggcattggtgcagcgt tcgcgttgcg gcagcagcgc 901 gcggatgcgg cggttgaaat tcaaaacggtttggcgttgc acttcggtcg 951 ggtgcgcggt caaaacggcg gtaacggacg tattgtccaactgccgctgc 1001 accgatttgc cgtcggcttt ccccgctttg agcctgcgga cggtttccgt1051 caggctgcct tctgctgcgt tgtggccggc atcttcgtgg atttggcggc 1101ggcgttcgtg gtgcacgtct tcggcgatat tcagaatctg ggcgaacagc 1151 ccgcaggcaagcgtcagatc gtaggtctgc cgttcgtcca attgcggcaa 1201 tactttttca atcaatgccgcgctgtcgtc ggaagtggac aagagtttga 1251 ccgtttcgac aaccaacggc gaggcttcttcgtgcaggag gttgaacagg 1301 gactgtttca aaaattccgc gtccgccgcc aaagccgcgtccttcggatt 1351 gttcaggata tgcagttgca tgattttcct ctcattgccg taaatactgt1401 aaatgtacct caaatgccgc atccgtgcca aaccgttcac actttaacca 1451ctcatgtccc gaaatgccgt ctgaagttga acgccgcccg acggcggcgt 1501 tacaatcgcccgcaactgtt tttttccgaa catcatcatg accgcgaccg 1551 aacacgacaa cgacgacgcactcctgctgc ggtacagccg ccacatcctc 1601 ttggacgaaa tcggcatcga agggcagcagaagctttccg ccgcgcatat 1651 tttggtcgtc ggctgcggcg gattgggcgc cgccgcccctgccctatctc 1701 gccgcctcgg gggtcggcac gctgaThis corresponds to the amino acid sequence <SEQ ID 1394; ORF 509.ng>:

g509.pep 1 MVAVCDERAV QRTLVAQFAQ QGGLFLLFVQ AVVVFQACVL EKLGNHIGVF 51ACVLAQVERH HVEAEHGHGT DEVCQTAFGK QAAAVVDKGT LQFFQIIEKF 101 LGRSIRLEKAEFAAHAQTER ARFAHSARHN VGNGAAVRFF GAGDFFVRRE 151 GCQCHYVVVD FDAADGKRQFAVKFVEFAAV KTEHGIGVAA EGKAQGFARN 201 KRIAVAVAAD PAADFKDIRN ADIGIGRLKVVFHLAVEFGQ GFKKAHREDG 251 HAVVDFVVDA EFVAARFAGL PQAQKHGVDF AAQPCQRVGIGAAFALRQQR 301 ADAAVEIQNG LALHFGRVRG QNGGNGRIVQ LPLHRFAVGF PRFEPADGFR351 QAAFCCVVAG IFVDLAAAFV VHVFGDIQNL GEQPAGKRQI VGLPFVQLRQ 401YFFNQCRAVV GSGQEFDRFD NQRRGFFVQE VEQGLFQKFR VRRQSRVLRI 451 VQDMQLHDFPLIAVNTVNVP QMPHPCQTVH TLTTHVPKCR LKLNAARRRR 501 YNRPQLFFSE HHHDRDRTRQRRRTPAAVQP PHPLGRNRHR RAAEAFRRAY 551 FGRRLRRIGR RRPCPISPPR GSAR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1395>:

m509.seq 1 ATGGTCGCTG TATGTGATAA ACGGGCTGTA CAGAGGACGT TGATGGCTCA 51ATTCGCGCAA CAGGGCGGTT TGTTTTTGCT CTTCGTTCAG GCGGTTGTAG 101 TCTTCCAAGCCTGCGTGTTG GAAAAGCTCG GCAACCACAT CGGCGTGTTT 151 GCCTGCGTGT TGGCGCAAGTCGAGCGGCAT CATGTGAAAG CCGAACACGG 201 ATACGGAACG GATGAGGTCT GCCAAACGGCCTTCGGCAAG CAGACGGCTG 251 CCGTTGTCGA TAAGGGAACG TTGCAATTTT TTCAAATCATCCAGAAACTC 301 TTGTGCCGAA GCATAAGGCT CGAGAAAGCC GAATTTGCAG CCCATACCCA351 AACCGAGCGC GCGCGCTTTG CCCATAGCGC GCGCCATAAT GTAGGCGATG 401GCGCGGCGGT AGGGTTCTTC GGCGCGGGCG ATTTCTTCGT CGGGCGATTT 451 GTCGGACAACGCCGTTACAT CGCCGTTGAC TTTGACGCGG CGGATGGAGA 501 GCGGCAGTTC GCGGTAGAGTTTGTCGAGTT CGCCGCGATA GAAGCGGAAC 551 ACGGCATCGG CGTGGCGGCG GAAGGCAAAGCGCAGGGTTT CGGCAGAAAC 601 AAACGGATTG CCGTCGCGGT CGCCGCCGAT CCAGCCGCCGATTTTGAGGA 651 TGTCCGGAAC GCGGACGCCG GGATAGGCCG TCTGAAAGTC GTGTTCCATC701 TTGCGGTAGA GCTTGGGCAG GGCTTCGAAA AAGCTCATCG GGAAGATGGA 751CACGCCGTTG TTGATTTCGT CGTTGACGCT GAGTTTGTGG CGGCGCGTTT 801 CGCTGGTCTGCCACAAGCCC AGCAGGATAG TGTCGATTtC GCgGCGCAGC 851 CGTGCCAGCG CGTCGGCATTGGTGCAGCGT TCgCGTTGCG GCAACAGTGC 901 GCGGATGCGG CGGTTGAAGC TTAAGACGGTTTGGCGTTGC ACTTCGGTCG 951 GGTGCGCGGT CAAAACGGCG GTAACGGACG TATTGTCCAACTGCCGCTGC 1001 ACCGATTTGC CGTCGGCTTT CCCCGCTTTG AGCCTGCGGA CGGTTTCCGT1051 CAGGCTGCCT TCCGCGCCGC CGCGTCCGGC TTCTTCGTGG ATTTGGCGGC 1101GGCGTTCGTG GTGCACGTCT TCGGCGATGT TCAAAATCTG GGCGAACAGG 1151 CCGCAGGCCAAGGTTAAATC GTGGGTTTGT TGTTCGTCCA ATTGCGGCAA 1201 TACTTTTTCA ATCAATGCCGCGCTGTCGTC GGAAGTGGAC AAGAGTTTGA 1251 CTGTTTCGAC AACCAACGGC GAGGCTTCTTCGTGCAGGAG GTTGAACAGG 1301 GATTGTTTCA GAAATTCCGC GTCCGCCGCC AAAGCCGCGTCCTTTGGATT 1351 GTTCAGAATA TGCAGTTGCA TGATTTTTCT CTCTCGTCTG CCGTAAATAT1401 TGTAAATGTA CCCCAAATGC CGCATCCGTG CCAAACCGTT CACACTTTAA 1451CCGCCCGTGT CCCGAAATGC CGTCTGAAGT TGAACGCCGC CCGACGGCAG 1501 CGTTACAATCGCCCGCAACT GTTTTtTTCC GAACATCATC ATGACCACGA 1551 CCGAACACGA CAACGACGATGCATTCCTGC TGCGGTACAG CCGCCACATC 1601 CTCTTGGACG AAATCGGCAT CGAAGGGCAGCAGAAACTTT CCGCCGCGCA 1651 TATTTTGGTC GTCGGCTGCG GCGGTTTGGG TGCCGCCGCACT.GCCCTAC 1701 CTTGCCGCTT CGGGTGTCGG CACGCTGAThis corresponds to the amino acid sequence <SEQ ID 1396; ORF 509>:

m509.pep 1 MVAVCDKRAV QRTLMAQFAQ QGGLFLLFVQ AVVVFQACVL EKLGNHIGVF 51ACVLAQVERH HVKAEHGYGT DEVCQTAFGK QTAAVVDKGT LQFFQIIQKL 101 LCRSIRLEKAEFAAHTQTER ARFAHSARHN VGDGAAVGFF GAGDFFVGRF 151 VGQRRYIAVD FDAADGERQFAVEFVEFAAI EAEHGIGVAA EGKAQGFGRN 201 KRIAVAVAAD PAADFEDVRN ADAGIGRLKVVFHLAVELGQ GFEKAHREDG 251 HAVVDFVVDA EFVAARFAGL PQAQQDSVDF AAQPCQRVGIGAAFALRQQC 301 ADAAVEAXDG LALHFGRVRG QNGGNGRIVQ LPLHRFAVGF PRFEPADGFR351 QAAFRAAASG FFVDLAAAFV VHVFGDVQNL GEQAAGQGXI VGLLFVQLRQ 401YFFNQCRAVV GSGQEFDCFD NQRRGFFVQE VEQGLFQKFR VRRQSRVLWI 451 VQNMQLHDFSLSSAVNIVNV PQMPHPCQTV HTLTARVPKC RLKLNAARRQ 501 RYNRPQLFFS EHHHDHDRTRQRRCIPAAVQ PPHPLGRNRH RRAAETFRRA 551 YFGRRLRRFG CRRTXPTLPL RVSAR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 509 shows 87.8% identity over a 575 aa overlap with a predicted ORF(ORF 509.ng) from N. gonorrhoeae:

m509/g509           10        20        30        40        50        60m509.pep   MVAVCDKRAVQRTLMAQFAQQGGLFLLFVQAVVVFQACVLEKLGNHIGVFACVLAQVERH  ||||||:|||||||:||||||||||||||||||||||||||||||||||||||||||||| g509  MVAVCDERAVQRTLVAQFAQQGGLFLLFVQAVVVFQACVLEKLGNHIGVFACVLAQVERH          10        20        30        40        50        60          70        80        90       100       110       120 m509.pep  HVKAEHGYGTDEVCQTAFGKQTAAVVDKGTLQFFQIIQKLLCRSIRLEKAEFAAHTQTER  ||:||||:|||||||||||||:|||||||||||||||:|:| |||||||||||||:|||| g509  HVEAEHGHGTDEVCQTAFGKQAAAVVDKGTLQFFQIIEKFLGRSIRLEKAEFAAHAQTER          70        80        90       100       110       120         130       140       150       160       170       180 m509.pep  ARFAHSARHNVGDGAAVGFFGAGDFFVGRFVGQRRYIAVDFDAADGERQFAVEFVEFAAI  ||||||||||||:|||| ||||||||| |   | :|::||||||||:|||||:||||||: g509  ARFAHSARHNVGNGAAVRFFGAGDFFVRREGCQCHYVVVDFDAADGKRQFAVKFVEFAAV         130       140       150       160       170       180         190       200       210       220       230       240 m509.pep  EAEHGIGVAAEGKAQGFGRNKRIAVAVAADPAADFEDVRNADAGIGRLKVVFHLAVELGQ  ::|||||||||||||||:|||||||||||||||||:|:|||| ||||||||||||||:|| g509  KTEHGIGVAAEGKAQGFARNKRIAVAVAADPAADFKDIRNADIGIGRLKVVFHLAVEFGQ         190       200       210       220       230       240         250       260       270       280       290       300 m509.pep  GFEKAHREDGHAVVDFVVDAEFVAARFAGLPQAQQDSVDFAAQPCQRVGIGAAFALRQQC  ||:|||||||||||||||||||||||||||||||: :|||||||||||||||||||||| g509  GFKKAHREDGHAVVDFVVDAEFVAARFAGLPQAQKHGVDFAAQPCQRVGIGAAFALRQQR         250       260       270       280       290       300         310       320       330       340       350       360 m509.pep  ADAAVEAXDGLALHFGRVRGQNGGNGRIVQLPLHRFAVGFPRFEPADGFRQAAFRAAASG  ||||||  :|||||||||||||||||||||||||||||||||||||||||||||  :::| g509  ADAAVEIQNGLALHFGRVRGQNGGNGRIVQLPLHRFAVGFPRFEPADGFRQAAFCCVVAG         310       320       330       340       350       360         370       380       390       400       410       420 m509.pep  FFVDLAAAFVVHVFGDVQNLGEQAAGQGXIVGLLFVQLRQYFFNQCRAVVGSGQEFDCFD  :|||||||||||||||:|||||| ||:  |||| ||||||||||||||||||||||| || g509  IFVDLAAAFVVHVFGDIQNLGEQPAGKRQIVGLPFVQLRQYFFNQCRAVVGSGQEFDRFD         370       380       390       400       410       420         430       440       450       460       470       480 m509.pep  NQRRGFFVQEVEQGLFQKFRVRRQSRVLWIVQNMQLHDFSLSSAVNIVNVPQMPHPCQTV  |||||||||||||||||||||||||||| |||:|||||| |  ||| ||||||||||||| g509  NQRRGFFVQEVEQGLFQKFRVRRQSRVLRIVQDMQLHDFPLI-AVNTVNVPQMPHPCQTV         430       440       450       460        470         490       500       510       520       530       540 m509.pep  HTLTARVPKCRLKLNAARRQRYNRPQLFFSEHHHDHDRTRQRRCIPAAVQPPHPLGRNRH  ||||::|||||||||||||:|||||||||||||||:|||||||  ||||||||||||||| g509  HTLTTHVPKCRLKLNAARRRRYNRPQLFFSEHHHDRDRTRQRRRTPAAVQPPHPLGRNRH480       490       500       510       520       530         550       560       570 m509.pep  RRAAETFRRAYFGRRLRRFGCRRTCPTLPLRVSAR  |||||:||||||||||||:| || ||  | | ||| g509  RRAAEAFRRAYFGRRLRRIGRRRPCPISPPRGSAR 540       550       560       570The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1397>:

a509.seq 1 ATGGTCGCTG TATGTGATGA ACGGACTGTA CAGTGGACGT TGATGGCTCA 51ATTCGCGCAA CAGGGCGGCT TGTTTTTGCT CTTCGTTGAG GCTGTTGTAG 101 TCTTCCAAGCCTGCGTGTTG GAAAAGCTCG GCAACCACAT CGGCGTGTTT 151 GCCTGCGTGT TGGCGCAGGTCGAGCGGCAT CATGTGGAAG CCGAACACGG 201 ATACGGAACG GATGAGGTCT GCCAAACGGCCTTCGGCAAG CAGGCGGCTG 251 CCGTTGTCGA TAAGGGAATG TTGCAATTTT TTCAAATCATCGAGAAATTC 301 TTGTGCCGAA GCATAAGGCT CGAGAAAGCC GAATTTGCAG CCCATACCCA351 AACCGAGCGC GCGCGCTTTG CCCATAGCGC GCGCCATAAT GTAGGCAATG 401GCGCGACGGT AGGGTTCTTC GGCGCGGGCG GTTTCTTCGT CGGGCGATTT 451 GTCGGACAACGCCATCACAT CGCCGTTGAC TTTGACGCGG CGGATGGAGA 501 GCGGCAGTTC GCGGTAGAGTTTGTCGAGTT CGCCACGGTA AAAACGGAAC 551 ACGGCATCGG CGTGGCGGCG GAAGGCAAAACGCAAGGTTT CGGCAGAAAC 601 GAACGGATTG CCGTCGCGGT CGCCGCCGAT CCAGCCGCCGATTTTGAGGA 651 TGTCCGGAAC GCGGACATCG GGATAGGCCG TCTGAAAGTC GTGTTCCATC701 TTGCGGTAGA GCTTGGGCAG GGCTTCAAAA AAGCTCATCG GAAAGATGGA 751CACGCCGTTG TTGATTTCGT CGTTGACGCT GAGTTTGTGG CGGCGCGTTT 801 CGCTGGTCTGCCACAAGCCC AGCAGGATAG TGTCGATTTC GCGGCGCAGC 851 CGTGCCAGCG CGTCGGCATTGGTACAGCGT TCGCGTTGCG GCAGCAGCGC 901 GCGGATGCGG CGGTTGAAAT TCAAGACGGTCTGGCGTTGC ACTTCGGTCG 951 GGTGCGCGGT CAAAACGGCG GTAACGGACG TATTGTCCAACTGCCGCTGC 1001 ACCGATTTGC CGTCGGCTTT CCCCGCTTTG AGCCTGCGGA CGGTTTCCGT1051 CAGGCTGCCT TCCGCGCCGC CGCGTCCGGC TTCTTCGTGG ATTTGGCGGC 1101GGCGTTCGTG GTGCACGTCT TCGGCGATGT TCAAAATCTG GGCGAACAGG 1151 CCGCAGGCCAAGGTTAAATC GTGGGTTTGT TGTTCGTCCA ATTGCGGCAA 1201 TACTTTTTCA ATCAATGCCGCGCTGTCGTC GGAAGTGGAC AAGAGTTTGA 1251 CCGTTTCGAC AACCAACGGC GAGGCTTCTTCGTGCAGGAG GTTGAACAGG 1301 GATTGTTTCA GAAATTCCGC GTCCGCCGCC AAAGCCGCGTCCTTTGGATT 1351 GTTCAGAATA TGCAGTTGCA TGATTTTTCT CTCATTGCCG TAAATACTGT1401 AAATGTACCT CAAATGCCGC ATCCGTGCCA AACCGTTCAC ACTTTAACCG 1451CCCGTGTCCC GAAATGCCGT CTGAAGTTGA ACGCCGCCCG ACGGCAGCGT 1501 TACAATCGCCCACAACTGTT TTT.TCCGAA CATCATCATG ACCACGACCG 1551 AACACGACAA CGACGATGCATTCCTGCTGC GGTACAGCCG CCACATCCTC 1601 TTGGACGAAA TTGGCATCGA AGGGCAGCAGAAACTTTCCG CCGCGCATAT 1651 TTTGGTCGTC GGCTGCGGCG GTTTGGGTGC CGCCGCCGATGCCCTATCTC 1701 GCCGCTTCCG GCATCGGCAC GCTGAThis corresponds to the amino acid sequence <SEQ ID 1398; ORF 509.a>:

a509.pep 1 MVAVCDERTV QWTLMAQFAQ QGGLFLLFVE AVVVFQACVL EKLGNHIGVF 51ACVLAQVERH HVEAEHGYGT DEVCQTAFGK QAAAVVDKGM LQFFQIIEKF 101 LCRSIRLEKAEFAAHTQTER ARFAHSARHN VGNGATVGFF GAGGFFVGRF 151 VGQRHHIAVD FDAADGERQFAVEFVEFATV KTEHGIGVAA EGKTQGFGRN 201 ERIAVAVAAD PAADFEDVRN ADIGIGRLKVVFHLAVELGQ GFKKAHRKDG 251 HAVVDFVVDA EFVAARFAGL PQAQQDSVDF AAQPCQRVGIGTAFALRQQR 301 ADAAVEIQDG LALHFGRVRG QNGGNGRIVQ LPLHRFAVGF PRFEPADGFR351 QAAFRAAASG FFVDLAAAFV VHVFGDVQNL GEQAAGQG*I VGLLFVQLRQ 401YFFNQCRAVV GSGQEFDRFD NQRRGFFVQE VEQGLFQKFR VRRQSRVLWI 451 VQNMQLHDFSLIAVNTVNVP QMPHPCQTVH TLTARVPKCR LKLNAARRQR 501 YNRPQLFXSE HHHDHDRTRQRRCIPAAVQP PHPLGRNWHR RAAETFRRAY 551 FGRRLRRFGC RXPCPISPLP ASAR*m509/a509 93.0% identity in 575 aa overlap          10        20        30        40        50        60 m509.pep  MVAVCDKRAVQRTLMAQFAQQGGLFLLFVQAVVVFQACVLEKLGNHIGVFACVLAQVERH  ||||||:|:|| |||||||||||||||||:|||||||||||||||||||||||||||||| a509  MVAVCDERTVQWTLMAQFAQQGGLFLLFVEAVVVFQACVLEKLGNHIGVFACVLAQVERH          10        20        30        40        50        60          70        80        90       100       110       120 m509.pep  HVKAEHGYGTDEVCQTAFGKQTAAVVDKGTLQFFQIIQKLLCRSIRLEKAEFAAHTQTER  ||:||||||||||||||||||:||||||| |||||||:|:|||||||||||||||||||| a509  HVEAEHGYGTDEVCQTAFGKQAAAVVDKGMLQFFQIIEKFLCRSIRLEKAEFAAHTQTER          70        80        90       100       110       120         130       140       150       160       170       180 m509.pep  ARFAHSARHNVGDGAAVGFFGAGDFFVGRFVGQRRYIAVDFDAADGERQFAVEFVEFAAI  ||||||||||||:||:||||||| ||||||||||::||||||||||||||||||||||:: a509  ARFAHSARHNVGNGATVGFFGAGGFFVGRFVGQRHHIAVDFDAADGERQFAVEFVEFATV         130       140       150       160       170       180         190       200       210       220       230       240 m509.pep  EAEHGIGVAAEGKAQGFGRNKRIAVAVAADPAADFEDVRNADAGIGRLKVVFHLAVELGQ  ::|||||||||||:||||||:||||||||||||||||||||| ||||||||||||||||| a509  KTEHGIGVAAEGKTQGFGRNERIAVAVAADPAADFEDVRNADIGIGRLKVVFHLAVELGQ         190       200       210       220       230       240         250       260       270       280       290       300 m509.pep  GFEKAHREDGHAVVDFVVDAEFVAARFAGLPQAQQDSVDFAAQPCQRVGIGAAFALRQQC  ||:||||:|||||||||||||||||||||||||||||||||||||||||||:||||||| a509  GFKKAHRKDGHAVVDFVVDAEFVAARFAGLPQAQQDSVDFAAQPCQRVGIGTAFALRQQR         250       260       270       280       290       300         310       320       330       340       350       360 m509.pep  ADAAVEAXDGLALHFGRVRGQNGGNGRIVQLPLHRFAVGFPRFEPADGFRQAAFRAAASG  ||||||  |||||||||||||||||||||||||||||||||||||||||||||||||||| a509  ADAAVEIQDGLALHFGRVRGQNGGNGRIVQLPLHRFAVGFPRFEPADGFRQAAFRAAASG         310       320       330       340       350       360         370       380       390       400       410       420 m509.pep  FFVDLAAAFVVHVFGDVQNLGEQAAGQGXIVGLLFVQLRQYFFNQCRAVVGSGQEFDCFD  ||||||||||||||||||||||||||||||||||||||||||||||||||||||||| || a509  FFVDLAAAFVVHVFGDVQNLGEQAAGQGXIVGLLFVQLRQYFFNQCRAVVGSGQEFDRFD         370       380       390       400       410       420         430       440       450       460       470       480 m509.pep  NQRRGFFVQEVEQGLFQKFRVRRQSRVLWIVQNMQLHDFSLSSAVNIVNVPQMPHPCQTV  |||||||||||||||||||||||||||||||||||||||||  ||| ||||||||||||| a509  NQRRGFFVQEVEQGLFQKFRVRRQSRVLWIVQNMQLHDFSLI-AVNTVNVPQMPHPCQTV         430       440       450       460       470         490       500       510       520       530       540 m509.pep  HTLTARVPKCRLKLNAARRQRYNRPQLFFSEHHHDHDRTRQRRCIPAAVQPPHPLGRNRH  |||||||||||||||||||||||||||| ||||||||||||||||||||||||||||| | a509  HTLTARVPKCRLKLNAARRQRYNRPQLFXSEHHHDHDRTRQRRCIPAAVQPPHPLGRNWH480       490       500       510       520       530         550       560       570 m509.pep  RRAAETFRRAYFGRRLRRFGCRRTXPTLPLRVSARX  ||||||||||||||||||||||   |  || :|||| a509  RRAAETFRRAYFGRRLRRFGCRXPCPISPLPASARX 540       550       560       570The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1399>:

g510.seq 1 atgccttcgc ggacaccgca gggaaaaagg ggttattcct gccccaagcg 51ggatagtgcc ttttggcagg cgttgtccat atcggttatt ttacgcgcaa 101 aatcgccgattgccaaatcg ccgccgttca gggaggtttt caataggtcg 151 tggacgacgt tgagcgcggccataatgacg attttttcgc tgtccgcgac 201 gcggccgcct tcgcggatgg cttcggctttgccgttgagc attccgactg 251 cctgcaacag tgtgtctttt tcttctgccg gcgtgttgacagtcagccgg 301 ggcgtgcatg acttcgatgt agacttgttc gatgttcatc ctttaatcct351 tattgctgcg tttcctgccg ttgggggagg cgcgctgcca gtgcgctgaThis corresponds to the amino acid sequence <SEQ ID 1400; ORF 510.ng>:

g510.pep 1 MPSRTPQGKR GYSCPKRDSA FWQALSISVI LRAKSPIAKS PPFREVFNRS 51WTTLSAAIMT IFSLSATRPP SRMASALPLS IPTACNSVSF SSAGVLTVSR 101 GVHDFDVDLFDVHPLILIAA FPAVGGGALP VR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1401>:

m510.seq 1 ATGCCTTCGC GGACACCGCA GGGnAAAAGG GGTTATTCCT GCGCCAAGCG 51GGATAGTGCT TTTTGGCAGG CGTTGTCCAT ATCGGCTATT TTACGCGCAA 101 AATCGCCGATTGCCAAATCG CCGCCGTTCA GGGAGGTTTT CAACAGGTCG 151 TGGACGACGT TGAGCGCGGCCATAATGACG ATTTTTTCGC TGTCCGCGAC 201 GCGTCCGCCT TCGCGGATGG CTTCGGCTTTGCCGTTGAGC ATTCCGACTG 251 CCTGCAACAG TGTGTCTTTT TCTTCTGCCG GCGTGTTGACGGTCAGCCGG 301 GGCGTGCAwG ACTTCsAtGT GGACTTGTTC GATGTTCATC CTTTAATCCT351 TATTGCTGCG TTTCCTGCCA TTGGGGGAGG CGCGCTGCCA GTGCGCTGAThis corresponds to the amino acid sequence <SEQ ID 1402; ORF 510>:

m510.pep 1 MPSRTPQGKR GYSCAKRDSA FWQALSISAI LRAKSPIAKS PPFREVFNRS 51WTTLSAAIMT IFSLSATRPP SRMASALPLS IPTACNSVSF SSAGVLTVSR 101 GVXDFXVDLFDVHPLILIAA FPAIGGGALP VR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 510 shows 96.2% identity over a 132 aa overlap with a predicted ORF(ORF 510.ng) from N. gonorrhoeae:

m510/g510         10        20        30        40        50        60m510.pep MPSRTPQGKRGYSCAKRDSAFWQALSISAILRAKSPIAKSPPFREVFNRSWTTLSAAIMT|||||||||||||| |||||||||||||:||||||||||||||||||||||||||||||| g510MPSRIPQGKRGYSCPKRDSAFWQALSISVILRAKSPIAKSPPFREVFNRSWITLSAAIMT        10        20        30        40        50        60        70        80        90       100       110       120 m510.pepIFSLSATRPPSRMASALPLSIPTACNSVSFSSAGVLTVSRGVXDFXVDLFDVHPLILIAA|||||||||||||||||||||||||||||||||||||||||| || |||||||||||||| g510IFSLSATRPPSRMASALPLSIPTACNSVSFSSAGVLTVSRGVHDFDVDLFDVHPLILIAA        70        80        90       100       110       120        130m510.pep FPAIGGGALPVRX |||:||||||||| g510 FPAVGGGALPVRX        130The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1403>:

a510.seq 1 ATGCCTTCGC GGACACCGCA GGGAAAAAGG GGTTATTCCT GCGCCAAGCG 51GGATAGTGCT TTTTGGCAGG CGTTGTCCAT ATCGGCTATT TTACGCGCAA 101 AATCGCCGATTGCCAAATCG CCGCCGTTCA GGGAGGTTTT CAACAGGTCG 151 TGGACGACGT TGAGCGCGGCCATAATGACG ATTTTTTCGC TGTCCGCGAC 201 GCGTCCGCCT TCGCGGATGG CTTCGGCTTTGCCGTTGAGC ATTCCGACTG 251 CCTGCAACAG TGTGTCTTTT TCTTCTGCCG GCGTGTTGACGGTCAGCCGG 301 G.CGTGCATG ACTTCGATGT GGACTTGTTC GATGTTCATC CTTTAATCCT351 TATTGCTGCG TTTCCTGCCG TTGGGGGAGG CGCGCTGCCA GTGCGCTGAThis corresponds to the amino acid sequence <SEQ ID 1404; ORF 510.a>:

a510.pep 1 MPSRTPQGKR GYSCAKRDSA FWQALSISAI LRAKSPIAKS PPFREVFNRS 51WTTLSAAIMT IFSLSATRPP SRMASALPLS IPTACNSVSF SSAGVLTVSR 101 XVHDFDVDLFDVHPLILIAA FPAVGGGALP VR* m510/a510 97.0% identity in 132 aa overlap        10        20        30        40        50        60 m510.pepMPSRTPQGKRGYSCAKRDSAFWQALSISAILRAKSPIAKSPPFREVFNRSWTTLSAAIMT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a510MPSRTPQGKRGYSCAKRDSAFWQALSISAILRAKSPIAKSPPFREVFNRSWTTLSAAIMT        10        20        30        40        50        60        70        80        90       100       110       120 m510.pepIFSLSATRPPSRMASALPLSIPTACNSVSFSSAGVLTVSRGVXDFXVDLFDVHPLILIAA|||||||||||||||||||||||||||||||||||||||| | || |||||||||||||| a510IFSLSATRPPSRMASALPLSIPTACNSVSFSSAGVLTVSRXVHDFDVDLFDVHPLILIAA        70        80        90       100       110       120        130m510.pep FPAIGGGALPVRX |||:||||||||| a510 FPAVGGGALPVRX        130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1405>:

g512.seq 1 atgaaagtgc ttgttttagg tgcgggtgtt gccggcgtat cctccgtgtg 51gtatctggca gaggccggac atgaagtaac ggtcatcgac cgcaccgagg 101 gtgtggcgatggaaaccagt tttgccaatg caggccagct ttcttacggc 151 tataccacgc cttgggctgcacccggtatt ccgaccaaag cactgaaacg 201 gctgtttaaa agccatccgc ctttactgttccgccctgac ggcggcctgt 251 atcaaatcga atggctgtgg cggatgctgc aaaactgcacggcaacgcgc 301 tatcaaatca ataaagagcg catggtcagg atttccgaat acagccgtga351 aatgttccgc cgttttgaag cgcaaaccga catgaatttt gagggacgca 401aaaaagggac gttgcagatt ttccgccaaa ccgaagaagt cgaagcggca 451 aaacaagacattgccgtttt ggaacgctac ggcgtgccgt accgccgtct 501 gaagcccgaa gaatgcgcagaattcgagcc tgcgctggca cgcgttaccg 551 ccaaaattgt cggcggtctg cacctgcctgcggatgcgac cggcgactgc 601 cgcctcttca ccgaaaacct gtacaaattg tgtcaagagaagggggtacg 651 gttctacttc aaccaaacca tcagccgcat cgaccacaac gggctgcgca701 tcaaagccgt tgaaacgaaa cagggcggtt tgaaacagat gccgttgtct 751gcgcgctcgg ctgcttcagc aggactgtgt tggcgcagtt ggatctcaat 801 ctgcccatttatcccgtcaa aggctattcc ttgaThis corresponds to the amino acid sequence <SEQ ID 1406; ORF 512.ng>:

g512.pep 1 MKVLVLGAGV AGVSSVWYLA EAGHEVTVID RTEGVAMETS FANAGQLSYG 51YTTPWAAPGI PTKALKRLFK SHPPLLFRPD GGLYQIEWLW RMLQNCTATR 101 YQINKERMVRISEYSREMFR RFEAQTDMNF EGRKKGTLQI FRQTEEVEAA 151 KQDIAVLERY GVPYRRLKPEECAEFEPALA RVTAKIVGGL HLPADATGDC 201 RLFTENLYKL CQEKGVRFYF NQTISRIDHNGLRIKAVETK QGGLKQMPLS 251 ARSAASAGLC WRSWISICPF IPSKAIP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1407>:

m512.seq (partial) 1 ..GTTTTGGAAC GCTACGGCGT GCCGTACCGC CGTCTGAAACCCGAAGAATG 51   TGCAGAATTT GAGCCTGCGC TGGCACGCGT TACCGCCAAA ATTGCCGGCG101   GCCTGCACCT GCCTGCAGAT GCGACCGGCG ACTggCGCCT CTTCACTGAA 151  AACCTATACA AATTGTGTCA GGAAAAGGGC GTACGGTTTC ATTTCAACCA 201  AAACATCAGC CGCATCGACC ACAACGGGCT GCGCATCAAA ACCGTTGAAA 251  CCAAACAGGG CGGTTTGAAG CAGATGCCGT TGTCTGCGCG CTCGGTTGCT 301  TCAGCAGGAC GGTTTTGGCG CAGTTGGATC TCAATCTGCC CATTTATCCC 351  GTCAAAGGCT ATTCCTTGAThis corresponds to the amino acid sequence <SEQ ID 1408; ORF 512>:

m512.pep (partial) 1 ..VLERYGVPYR RLKPEECAEF EPALARVTAK IAGGLHLPADATGDWRLFTE 51   NLYKLCQEKG VRFHFNQNIS RIDHNGLRIK TVETKQGGLK QMPLSARSVA101   SAGRFWRSWI SICPFIPSKA IP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 512 shows 93.4% identity over a 122 aa overlap with a predicted ORF(ORF 512.ng) from N. gonorrhoeae:

m512/g512                                       10        20        30m512.pep                               VLERYGVPYRRLKPEECAEFEPALARVTAK                              |||||||||||||||||||||||||||||| g512TDMNFEGRKKGTLQIFRQTEEVEAAKQDIAVLERYGVPYRRLKPEECAEFEPALARVTAK  130       140       150       160       170       180        40        50        60        70        80        90 m512.pepIAGGLHLPADATGDWRLFTENLYKLCQEKGVRFHFNQNISRIDHNGLRIKTVETKQGGLK|:|||||||||||| ||||||||||||||||||:|||:||||||||||||:||||||||| g512IVGGLHLPADATGDCRLFTENLYKLCQEKGVRFYFNQTISRIDHNGLRIKAVETKQGGLK  190       200       210       220       230       240       100       110       120 m512.pep QMPLSARSVASAGRFWRSWISICPFIPSKAIP||||||||:||||  ||||||||||||||||| g512 QMPLSARSAASAGLCWRSWISICPFIPSKAIP  250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1409>:

a512.seq 1 ATGAAAGTGC TTGTTTTAGG TGCTGGTGTT GCCGGCGTAT CTTCCGCGTG 51GTATCTGGCA GAGGCAGGAC ATGAAGTAAC GGTCATCGAC CGCGCCGAGG 101 GCGTGGCGATGGAAACCAGT TTTGCCAACG CAGGCCAGCT TTCTTACGGC 151 TATACCACGC CTTGGGCTGCACCCGGTATT CCGACCAAAG CACTGAAATG 201 GCTGTTTAAA AGCCATCCGC CTTTGCTGTTTCGCCCCGAC GGCAGCCTGT 251 ATCAAATCGA ATGGCTGTGG CAGATGCTGC AACACTGCACGGCAGCGCGC 301 TATCAAATCA ATAAAGAGCG CATGGTCAGG ATGTCCGAAT ACAGCCGTGA351 AATGTTCCGC CGTTTTGAAG CGCAAACCGG CATGAATTTT GAGGGACGCA 401AAAAAGGGAC GTTGCAGATT TTCCGCCAAA CCAAAGAAGT CGAAGCGGCA 451 AAACAAGACATTGCCGTTTT GGAACGCTAC GGCGTGCCGT ACCGCCGTCT 501 GAAGCCCGAA GAATGCGCAGAATTCGAGCC TGCGCTGGCA CGCGTTACCG 551 CCAAAATTGC CGGCGGCCTG CACCTGCCCGCAGACGCGAC CGGCGACTGC 601 CGCCTCTTCA CTGAAAACCT GTACAAATTG TGTCAGGAAAAGGGCGTACG 651 GTTTCATTTC AACCAAACCA TCAGCCGCAT CGACCACAAC GGGCTGCGCA701 TCAAAACCGT TGAAACGAAA CAGGGCGGTT TGAAGCAGAT GCCGTTGTCT 751GCGCGCTCGG CTGCTTCAGC AGGACGGTTT TGGCGCAAGT GGATCTCAAT 801 CTGCCGATTTATCCCGTCAA AGGCTATTCC TTGAThis corresponds to the amino acid sequence <SEQ ID 1410; ORF 512.a>:

a512.pep 1 MKVLVLGAGV AGVSSAWYLA EAGHEVTVID RAEGVAMETS FANAGQLSYG 51YTTPWAAPGI PTKALKWLFK SHPPLLFRPD GSLYQIEWLW QMLQHCTAAR 101 YQINKERMVRMSEYSREMFR RFEAQTGMNF EGRKKGTLQI FRQTKEVEAA 151 KQDIAVLERY GVPYRRLKPEECAEFEPALA RVTAKIAGGL HLPADATGDC 201 RLFTENLYKL CQEKGVRFHF NQTISRIDHNGLRIKTVETK QGGLKQMPLS 251 ARSAASAGRF WRKWISICRF IPSKAIP* m512/a512 95.9%identity in 122 aa overlap                                      10        20        30 m512.pep                              VLERYGVPYRRLKPEECAEFEPALARVTAK                              |||||||||||||||||||||||||||||| a512TGMNFEGRKKGTLQIFRQTKEVEAAKQDIAVLERYGVPYRRLKPEECAEFEPALARVTAK  130       140       150       160       170       180        40        50        60        70        80        90 m512.pepIAGGLHLPADATGDWRLFTENLYKLCQEKGVRFHFNQNISRIDHNGLRIKTVETKQGGLK|||||||||||||| ||||||||||||||||||||||:|||||||||||||||||||||| a512IAGGLHLPADATGDCRLFTENLYKLCQEKGVRFHFNQTISRIDHNGLRIKTVETKQGGLK  190       200       210       220       230       240       100       110       120 m512.pepQMPLSARSVASAGRFWRSWISICPFIPSKAIPX ||||||||:||||||||:||||| ||||||||| a512QMPLSARSAASAGRFWRKWISICRFIPSKAIPX   250       260       270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1411>:

g513.seq 1 ATGGGTTCCG CGCCGAACGC CGCCGCCGCC GCCGAAGTGA AACACCCTGT 51TTCGCAAGGT ATGATTCAAA TGCTGGGCGT GTTTGTCGAT ACCATCATCG 101 TTTGTTCTTGCACCGCCTTC ATCATCTTGA TTTACCAACA GCCTTATGGC 151 GATTTGAGCG GTGCGGCGCTGAcgcAGGCG GCGATTGTCA GCCAAGTGGG 201 GCAATGGGGC GCGGGTTTCC TCGCCGTCATCCTGTTTATG TTTGCCTTTT 251 CCACCGTTAT CGGCAACTAT GCCTATGCCG AGTCCAACGTCCAATTCATC 301 AAAAGCCATT GGCTGATTAC CGCCGTTTTC CGTATGCTGG TTTTGGCGTG351 GGTCTATTTC GGCGCGGTTG CCAATGTGCC TTTGGTCTGG GATATGGCGG 401ATATGGCGAT GGGCATCATG GCGTGGATCA ACCTCGTCGC CATCCTGCTG 451 CTCTCGCCatTGGCGTTTAT GCTGCTGCGC GATTACACCG CCAAGCTGAA 501 AATGGGCAAA GACCCCGAGTTCAAACTTTc cgAACATCCG GGCCTGAAAC 551 GCCGCATCAA ATCCGATGTT TGGTAAThis corresponds to the amino acid sequence <SEQ ID 1412; ORF 513.ng>:

g513.pep 1 MGSAPNAAAA AEVKHPVSQG MIQMLGVFVD TIIVCSCTAF IILIYQQPYG 51DLSGAALTQA AIVSQVGQWG AGFLAVILFM FAFSTVIGNY AYAESNVQFI 101 KSHWLITAVFRMLVLAWVYF GAVANVPLVW DMADMAMGIM AWINLVAILL 151 LSPLAFMLLR DYTAKLKMGKDPEFKLSEHP GLKRRIKSDV W*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1413>:

m513.seq 1 ATGGGTTCCG CGCCGAACGC CGCCGCCGCC GCCGAAGTGA AACACCCTGT 51TTCGCAAGGT ATGATTCAAA TGCTGGGCGT GTTTGTCGAT ACCATCATCG 101 TTTGTTCTTGCACCGCCTTC ATCATCTTGA TTTACCAACA GCCTTATGGC 151 GATTTGAGCG GTGCGGCGCTGAcgcAGGCG GCGATTGTCA GCCAAGTGGG 201 GCAATGGGGC GCGGGTTTCC TCGCCGTCATCCTGTTTATG TTTGCCTTTT 251 CCACCGTTAT CGGCAACTAT GCCTATGCCG AGTCCAACGTCCAATTCATC 301 AAAAGCCATT GGCTGATTAC CGCCGTTTTC CGTATGCTGG TTTTGGCGTG351 GGTCTATTTC GGCGCGGTTG CCAATGTGCC TTTGGTCTGG GATATGGCGG 401ATATGGCGAT GGGCATCATG GCGTGGATCA ACCTCGTCGC CATCCTGCTG 451 CTCTCGCCatTGGCGTTTAT GCTGCTGCGC GATTACACCG CCAAGCTGAA 501 AATGGGCAAA GACCCCGAGTTCAAACTTTc cgAACATCCG GGCCTGAAAC 551 GCCGCATCAA ATCCGATGTT TGGTAAThis corresponds to the amino acid sequence <SEQ ID 1414; ORF 513>:

m513.pep 1 MGSAPNAAAA AEVKHPVSQG MIQMLGVFVD TIIVCSCTAF IILIYQQPYG 51DLSGAALTQA AIVSQVGQWG AGFLAVILFM FAFSTVIGNY AYAESNVQFI 101 KSHWLITAVFRMLVLAWVYF GAVANVPLVW DMADMAMGIM AWINLVAILL 151 LSPLAFMLLR DYTAKLKMGKDPEFKLSEHP GLKRRIKSDV W*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 513 shows 99.5% identity over a 191 aa overlap with a predicted ORF(ORF 513.ng) from N. gonorrhoeae:

m513/g513         10        20        30        40        50        60m513.pep MGSAPNAAAAAEVKHPVSQGMIQMLGVFVDTIIVCSCTAFIILIYQQPYGDLSGAALTQA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g513MGSAPNAAAAAEVKHPVSQGMIQMLGVFVDTIIVCSCTAFIILIYQQPYGDLSGAALTQA        10        20        30        40        50        60        70        80        90       100       110       120 m513.pepAIVSQVGQWGAGFLAVILFMFAFSTVIGNYAYAESNVQFIKSHWLITAVFRMLVLAWVYF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g513AIVSQVGQWGAGFLAVILFMFAFSTVIGNYAYAESNVQFIKSHWLITAVFRMLVLAWVYF        70        80        90       100       110       120       130       140       150       160       170       180 m513.pepGAVANVPLVWDMADMAMGIMAWINLVAILLLSPLAFMXLRDYTAKLKMGKDPEFKLSEHP||||||||||||||||||||||||||||||||||||| |||||||||||||||||||||| g513GAVANVPLVWDMADMAMGIMAWINLVAILLLSPLAFMLLRDYTAKLKMGKDPEFKLSEHP       130       140       150       160       170       180        190m513.pep GLKRRIKSDVW ||||||||||| g513 GLKRRIKSDVW        190The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1415>:

a513.seq 1 ATGAACGAGA ACTTTACCGA ATGGCTGCAC GGCTGGGTCG GCGCCATCAA 51CGATCCGATG TGGTCATACT TGGTTTATNT GCTTTTGGGT ACGGGGCTTT 101 TCTTCACCGTAACCACGGGC TTTGTCCAAT TCCGCCTGTT CGGGCGCAGC 151 ATCAAAGAAA TGCTCGGCGGCCGCAAACAG GGGGACGACC CTCACGGCAT 201 CACGCCGTTT CAGGCATTTG TAACCGGCCTTGCCAGCCGC GTGGGCGTGG 251 GCAATATCGC GGGCGTGGCC ATCGCCATCA AAGTCGGCGGACCGGGCGCG 301 GTGTTTTGGA TGTGGGTAAC CGCCTTAATC GGTATGAGTT CGGCGTTTGT351 CGAATCTTCG CTGGCGCAGC TCTTTAAAGT CCGCGACTAC GACAACCACC 401ATTTCCGGGG CGGCCCTGCC TACTACATCA CTCAAGGGCT GGGGCAGAAA 451 TGGCTGGGCGTGTTGTTCGC CCTGAGCCTG ATTTTCTGTT TCGGCTTTGT 501 GTTTGAAGCG GTTCAGACCAATACCATTGC CGATACCGTC AAAGCGGCGT 551 GGGGTTGGGA GCCTCATTAT GTCGGCGTCGCCCTGGTGAT TTTAACCGCG 601 CCGATTATCT TCGGCGGCAT CAGGCGCATA TCTAAAGCGGCGGAAATCGT 651 CGTCCCCCTG ATGGCGGTTT TGTACCTCTT TATCGCGCTT TTCATCATTT701 TGACCAATAT TCCGATGATT CCGGACGTGT TCGGTCAGAT TTTTTCGGGC 751GCGTTCAAAT TCGACGCGGC AGCAGGCGGC TTACTCGGCG GTCTGATTTC 801 GCAAACGATGATGATGGGCA TCAAACGCGG CCTGTATTCC AACGAGGCGG 851 GTATGGGTTC CGCGCCGAACGCCGCCGCCG CCGCCGAAGT GAAACACCCT 901 GTTTCGCAAG GTATGATTCA AATGCTGGGCGTGTTTGTCG ATACCATCAT 951 CGTTTGTTCT TGCACCGCCT TCATCATCTT GATTTACCAACAGCCTTACG 1001 GCGATTTGAG CGGTGCGGCG CTGACGCAGG CGGCGATTGT CAGCCAAGTG1051 GGGCAATGGG GCGCGGGCTT CCTCGCCGTC ATCCTGTTTA TGTTTGCCTT 1101TTCCACCGTT ATCGGCAACT ATGCCTATGC CGAGTCCAAC GTCCAATTCA 1151 TCAAAAGCCATTGGCTGATT ACCGCCGTTT TCCGTATGCT GGTTTTGGCG 1201 TGGGTCTATT TCGGCGCGGTTGCCAATGTG CCTTTGGTCT GGGATATGGC 1251 GGATATGGCG ATGGGCATTA TGGCGTGGATCAACCTTGTC GCCATCCTGC 1301 TGCTCTCGCC CTTGGCGTTT ATGCTGCTGC GCGATTACACCGCCAAGCTG 1351 AAAATGGGCA AAGACCCCGA GTTCAAACTT TCCGAACATC CGGGCCTGAA1401 ACGCCGTATC AAATCCGACG TTTGGTAAThis corresponds to the amino acid sequence <SEQ ID 1416; ORF 513.a>:

a513.pep 1 MNENFTEWLH GWVGAINDPM WSYLVYXLLG TGLFFTVTTG FVQFRLFGRS 51IKEMLGGRKQ GDDPHGITPF QAFVTGLASR VGVGNIAGVA IAIKVGGPGA 101VFWMWVTALI GMSSAFVESS LAQLFKVRDY DNHHFRGGPA YYITQGLGQK 151WLGVLFALSL IFCFGFVFEA VQTNTIADTV KAAWGWEPHY VGVALVILTA 201 PIIFGGIRRISKAAEIVVPL MAVLYLFIAL FIILTNIPMI PDVFGQIFSG 251 AFKFDAAAGG LLGGLISQTMMMGIKRGLYS NEAGMGSAPN AAAAAEVKHP 301 VSQGMIQMLG VFVDTIIVCS CTAFIILIYQQPYGDLSGAA LTQAAIVSQV 351 GQWGAGFLAV ILFMFAFSTV IGNYAYAESN VQFIKSHWLITAVFRMLVLA 401 WVYFGAVANV PLVWDMADMA MGIMAWINLV AILLLSPLAF MLLRDYTAKL451 KMGKDPEFKL SEHPGLKRRI KSDVW* m513/a513 100.0% identity in 191 aaoverlap                                       10        20        30m513.pep                               MGSAPNAAAAAEVKHPVSQGMIQMLGVFVD                              |||||||||||||||||||||||||||||| a513DAAAGGLLGGLISQTMMMGIKRGLYSNEAGMGSAPNAAAAAEVKHPVSQGMIQMLGVFVD   260       270       280       290       300       310        40        50        60        70        80        90 m513.pepTIIVCSCTAFIILIYQQPYGDLSGAALTQAAIVSQVGQWGAGFLAVILFMFAFSTVIGNY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a513TIIVCSCTAFIILIYQQPYGDLSGAALTQAAIVSQVGQWGAGFLAVILFMFAFSTVIGNY   320       330       340       350       360       370       100       110       120       130       140       150 m513.pepAYAESNVQFIKSHWLITAVFRMLVLAWVYFGAVANVPLVWDMADMAMGIMAWINLVAILL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a513AYAESNVQFIKSHWLITAVFRMLVLAWVYFGAVANVPLVWDMADMAMGIMAWINLVAILL   380       390       400       410       420       430       160       170       180       190 m513.pepLSPLAFMLLRDYTAKLKMGKDPEFKLSEHPGLKRRIKSDVWX|||||||||||||||||||||||||||||||||||||||||| a513LSPLAFMLLRDYTAKLKMGKDPEFKLSEHPGLKRRIKSDVWX   440       450       460       470The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1417>:

g515.seq 1 atggttcaaa tacaggttgt gcgcgccgcc ggcgttgccc gtggtctgca 51ttccgagttt gcgcgcgctg taactgccga ggaaatagcc ttcgacaatg 101 ccgttttgaatcacgaagcg cggcgcggtg gcaacacctt ccgcatcaaa 151 atagctgctg cggaaagagcgggggatgtg cggttcttcg cgcaggttga 201 ggaaatcggg caggactttt ttgccgatgctgtcgatcag gaaactgctt 251 tggcggtaga gcgcgccgcc ggagagtgtg ccgacgaggtgtccgatcag 301 cccgcccgaa acggtggtat cgaagaggac ggggtagctg cctgtcggga351 tgctgcggct gccgagtcgg cgcaaagtgc ggcgggcggc ggtttgaccg 401atggtttcgg ggctgtccat atccggatgg cggcaggcgg aatcgtacca 451 gtagtcgcgctgcattccgt tttcgtcggc ggcgacgacg ctgcaggaaa 501 tgctgtggtg cgtgctttgccggtgtgcgg caaaaccgtg ggtgttgccg 551 taaacgtatt ggtactgtcc ggtttgcaccgccgcgcctt cggagttttc 601 gatgcggctg tccgtgtcca acgctgcctg ttcgcattgttttgccaagc 651 cgacggcggc ttccgtatcc aaatcccatt cgtggtaaag gtcggggtcg701 ccgatgtgtt gcgccatcaa ctcggggtcg gcaagtccgg cgcaaccgtc 751ttcggcggtg tggcgggcga tgtcggcggc ggcgcggacg gtgtcgcgca 801 gggcttgttcggagaagtcg gcggtgccgg cgcggccttt gcgtttgccg 851 acgtaaacgg taatgtccagcgatttgtcc tgctggaact cgatttgttc 901 gatttcgccc aagcgcacgc tgacgctttgtccgagcgat tcgctgaagt 951 cggcttcggc ggcggtcgcg cccgctgctt ttgccaagtcgagcgtgcgg 1001 cggcagaggt cgaggagttc ggaagcggtg tggttgaaca gcataacaat1051 ctttcttggt ggagcgttgt ggcattttaaThis corresponds to the amino acid sequence <SEQ ID 1418; ORF 515.ng>:

g515.pep 1 MVQIQVVRAA GVARGLHSEF ARAVTAEEIA FDNAVLNHEA RRGGNTFRIK 51IAAAERAGDV RFFAQVEEIG QDFFADAVDQ ETALAVERAA GECADEVSDQ 101 PARNGGIEEDGVAACRDAAA AESAQSAAGG GLTDGFGAVH IRMAAGGIVP 151 VVALHSVFVG GDDAAGNAVVRALPVCGKTV GVAVNVLVLS GLHRRAFGVF 201 DAAVRVQRCL FALFCQADGG FRIQIPFVVKVGVADVLRHQ LGVGKSGATV 251 FGGVAGDVGG GADGVAQGLF GEVGGAGAAF AFADVNGNVQRFVLLELDLF 301 DFAQAHADAL SERFAEVGFG GGRARCFCQV ERAAAEVEEF GSGVVEQHNN351 LSWWSVVAF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1419>:

m515.seq (partial) 1 ..GGAAAGAGCG GGGGATGTGC GTTCTTCGCG CAGGTTGAGGAAATCGGGCA 51   GGACTTTTCT GCCGATGCTG TCGATCAGGA AACTGCTTTG GCGGTAGAGC101   GCGCCGCCGG AGAGTGCGCC GACGAGGTGT CCGATAAGAC CGCCCGAAAC 151  GGTGGTATCG AAGAGGACGG GGTAGCTGCC TGTCGGGATG CTGCGGCTGC 201  CGAGTCGGCG CAAAGTGCGG CGGGCGGCGG TTTGACCGAT GGTTTCGGGG 251  CTGTCCATAT CCGGATGGCG GCAGGCGGAA TCGTACCAGT AGTCGCGCTG 301  CATGCCGTTT TCGTCGGCGG CAACGACGCT GCAGGAAATG CTGTGGTGCG 351  TGCCTTGCCG GTGTGCGGCA AAACCGTGGG TGTTGCCGTA AACGTATTGG 401  TAATGGCCGG TTTGCACCGC CGCGCCTTCG GAGTTTTCGA TGCGCTCATC 451  CTCGTTCAGG GCGGCTTGTT CGCATTGTTT TGCCAAGCCG ACGGCGGCTk 501  CCGTATCCAA ATCCCATTCG TGGTAAAGGT CGGGGTCGCC GATGTGTTTT 551  GCCATCAGAC AGGCATCGGC AAGTCCGGCG CAACCGTCTT CGGCGGTGTG 601  GCGGGCGATG TCGATGGCGG CTTTGACGGT GTCTTGCAGG GCTTTTTCGG 651  AGAAGTCGGC AGTACTGGCG CGGCCTTTGC GTTTGCCGAC GTAAACGGTA 701  ATGTCCAGCG ACTTGTCCTG CTGGAACTCG ATTTGTTsGA TTTsGCCCAG 751  CCGCACGCTG ACGCTTTGTC CCAATGATTC GCTGAAATCG GCTTCGGCGG 801  CGGTTGCGCC CGTCGCTTTT GCCAAGTCGA GCGTGCGGCG GCAGAGGTCG 851  AGGAGTTCGG AAGCGGTGTG GTTgAACAGC ATAGAAATCT TTCTTGATGA 901  TGCTTTGCGG CATTTTAAThis corresponds to the amino acid sequence <SEQ ID 1420; ORF 515>:

m515.pep (partial) 1 ..GKSGGCAFFA QVEEIGQDFS ADAVDQETAL AVERAAGECADEVSDKTARN 51   GGIEEDGVAA CRDAAAAESA QSAAGGGLTD GFGAVHIRMA AGGIVPVVAL101   HAVFVGGNDA AGNAVVRALP VCGKTVGVAV NVLVMAGLHR RAFGVFDALI 151  LVQGGLFALF CQADGGXRIQ IPFVVKVGVA DVFCHQTGIG KSGATVFGGV 201  AGDVDGGFDG VLQGFFGEVG STGAAFAFAD VNGNVQRLVL LELDLXDXAQ 251  PHADALSQXF AEIGFGGGCA RRFCQVERAA AEVEEFGSGV VEQHRNLSXX 301   CFAAF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 515 shows 85.9% identity over a 304 aa overlap with a predicted ORF(ORF 515.ng) from N. gonorrhoeae:

m515/g515                                      10        20        30m515.pep                              GKSGGCAFFAQVEEIGQDFSADAVDQETALA                              ::|   |||||||||||| ||||||||||| g515AEEIAFDNAVLNHEARRGGNIFRIKIAAAERAGDVRFFAQVEEIGQDFFADAVDQETALA   30        40        50        60        70        80       40        50        60        70        80        90 m515.pepVERAAGECADEVSDKTARNGGIEEDGVAACRDAAAAESAQSAAGGGLTDGFGAVHIRMAA||||||||||||||: |||||||||||||||||||||||||||||||||||||||||||| g515VERAAGECADEVSDQPARNGGIEEDGVAACRDAAAAESAQSAAGGGLTDGFGAVHIRMAA   90       100       110       120       130       140      100       110       120       130       140       150 m515.pepGGIVPVVALHAVFVGGNDAAGNAVVRALPVCGKTVGVAVNVLVMAGLHRRAFGVFDALIL||||||||||:|||||:||||||||||||||||||||||||||::|||||||||||| : g515GGIVPVVALHSVFVGGDDAAGNAVVRALPVCGKTVGVAVNVLVLSGLHRRAFGVFDAAVR  150       160       170       180       190       200      160       170       180       190       200       210 m515.pepVQGGLFALFCQADGGXRIQIPFVVKVGVADVFCHQTGIGKSGATVFGGVAGDVDGGFDGV||  ||||||||||| |||||||||||||||: || |:||||||||||||||| || ||| g515VQRCLFALFCQADGGFRIQIPFVVKVGVADVLRHQLGVGKSGATVFGGVAGDVGGGADGV  210       220       230       240       250       260      220       230       240       250       260       270 m515.pepLQGFFGEVGSTGAAFAFADVNGNVQRLVLLELDLXDXAQPHADALSQXFAEIGFGGGCAR||:|||||::|||||||||||||||:||||||| | || ||||||: |||:||||| || g515AQGLFGEVGGAGAAFAFADVNGNVQRFVLLELDLFDFAQAHADALSERFAEVGFGGGRAR  270       280       290       300       310       320      280       290       300 m515.pepRFCQVERAAAEVEEFGSGVVEQHRNLSXXCFAAF ||||||||||||||||||||||| |||    :||g515 CFCQVERAAAEVEEFGSGVVEQHNNLSWWSVVAF   330       340       350The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1421>:

a515.seq 1 ATGGTTCAAA TAAAGGTTGT GCGCGCCGCC GGCGTTGCCC GTGGTCTGCA 51TTCCGAGTTT GCGCGCGCTG TAACTGCTGA GGAAATAGCC TTCGACAATG 101 CCGTTTTGAATCACGAAGCG CGGTGCGGTG GCAACGCCTT CCGCATCAAA 151 ATAGCTGCTG CGGAAAGAGCGGGGGATGTG CGGTTCTTCG CGCAGGTTGA 201 GGAAATCGGG CAGGACTTTT TTGCCGATGCTGTCGATCAG GAAACTGCTT 251 TGGCGGTAGA GCGCTCCGCC GGAGAGTGCG CCGACGAGGTGTCCGATAAG 301 ACCGCCCGAA ACGGTGGTAT CGAAGAGGAC GGGGTAGTTG CCTGTCGGGA351 TGCTGCGGCT GCCGAGTCGG CGCAAAGTGC GGCGGGCGGC GGTTTGACCG 401ATGGTTTCGG GGCTGTCCAT ATCCGGATGG CGGCAGGCGG AATCGTACCA 451 GTAGTCGCGCTGCATGCCGT TTTCGTCGGC GGCAACGACG CTGCAGGAAA 501 TGCTGTGGTG CGTGCTTTGCCGGTGTGCGG CAAAACCGTA GGTGTTGCCG 551 TAAACGTATT GGTAATGGCC GGTTTGCACCGCCGCGCCTT CGGAGTTTTC 601 GATGCGCTCA TCCTCGTTCA GGGCGGCTTG TTCGCATTGTTTTGCCAAGC 651 CGACGGCGGC TTCCGTATCC AAATCCCATT CGTGGTAAAG GTCGGGGTCG701 CCGATGTGTT GCGCCATCAA CTCGGGGTCG GCAAGTCCGG CGCAACCGTC 751TTCGGCGGTG TGGCGGGCGA TGTCNNNNGC GGCGCGGACG GTGTCGCGCA 801 GGGCTTGTTCGGAGAAATCG GCGGTGCCGG CGCGGCCTTT GCGTTTGCCG 851 ACGTAAACGG TAATGTCCAGCGACTTGTCC TGCTGAAACT CGATTTGTTC 901 GATTTCGCCC AGCCGCACGC TGACGCTTTGTCCCAATGAT TCGCTGAAAT 951 CGGCTTCGGC GGCGGTTGCG CCCGTCGCTT TTGCCAAGTCGAGCGTGCGG 1001 CGGCAGAGGT CGAGGAGTTC GGAAGCGGTG TGGTTGAACA GCATAGAAAT1051 CTTTCTTGAT GATGCTTTGC GGCATTTTAAThis corresponds to the amino acid sequence <SEQ ID 1422; ORF 515.a>:

a515.pep 1 MVQIKVVRAA GVARGLHSEF ARAVTAEEIA FDNAVLNHEA RCGGNAFRIK 51IAAAERAGDV RFFAQVEEIG QDFFADAVDQ ETALAVERSA GECADEVSDK 101 TARNGGIEEDGVVACRDAAA AESAQSAAGG GLTDGFGAVH IRMAAGGIVP 151 VVALHAVFVG GNDAAGNAVVRALPVCGKTV GVAVNVLVMA GLHRRAFGVF 201 DALILVQGGL FALFCQADGG FRIQIPFVVKVGVADVLRHQ LGVGKSGATV 251 FGGVAGDVXX GADGVAQGLF GEIGGAGAAF AFADVNGNVQRLVLLKLDLF 301 DFAQPHADAL SQ*FAEIGFG GGCARRFCQV ERAAAEVEEF GSGVVEQHRN351 LS**CFAAF* m515/a515 92.1% identity in 304 aa overlap                                     10        20        30 m515.pep                             GKSGGCAFFAQVEEIGQDFSADAVDQETALA                              ::|   |||||||||||| ||||||||||| a515AEEIAFDNAVLNHEARCGGNAFRIKIAAAERAGDVRFFAQVEEIGQDFFADAVDQETALA   30        40        50        60        70        80       40        50        60        70        80        90 m515.pepVERAAGECADEVSDKTARNGGIEEDGVAACRDAAAAESAQSAAGGGLTDGFGAVHIRMAA|||:|||||||||||||||||||||||:|||||||||||||||||||||||||||||||| a515VERSAGECADEVSDKTARNGGIEEDGVVACRDAAAAESAQSAAGGGLTDGFGAVHIRMAA   90       100       110       120       130       140      100       110       120       130       140       150 m515.pepGGIVPVVALHAVFVGGNDAAGNAVVRALPVCGKTVGVAVNVLVMAGLHRRAFGVFDALIL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a515GGIVPVVALHAVFVGGNDAAGNAVVRALPVCGKTVGVAVNVLVMAGLHRRAFGVFDALIL  150       160       170       180       190       200      160       170       180       190       200       210 m515.pepVQGGLFALFCQADGGXRIQIPFVVKVGVADVFCHQTGIGKSGATVFGGVAGDVDGGFDGV||||||||||||||| |||||||||||||||: || |:|||||||||||||||  | ||| a515VQGGLFALFCQADGGFRIQIPFVVKVGVADVLRHQLGVGKSGATVFGGVAGDVXXGADGV  210       220       230       240       250       260      220       230       240       250       260       270 m515.pepLQGFFGEVGSTGAAFAFADVNGNVQRLVLLELDLXDXAQPHADALSQXFAEIGFGGGCAR||:|||:|::|||||||||||||||||||:||| | ||||||||||||||||||||||| a515AQGLFGEIGGAGAAFAFADVNGNVQRLVLLKLDLFDFAQPHADALSQXFAEIGFGGGCAR  270       280       290       300       310       320      280       290       300 m515.pepRFCQVERAAAEVEEFGSGVVEQHRNLSXXCFAAFX |||||||||||||||||||||||||||||||||||a515 RFCQVERAAAEVEEFGSGVVEQHRNLSXXCFAAFX  330       340       350       360The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1423>:

g515-1.seq 1 ATGGTTCAAA TACAGGTTGT GCGCGCCGCC GGCGTTGCCC GTGGTCTGCA 51TTCCGAGTTT GCGCGCGCTG TAACTGCCGA GGAAATAGCC TTCGACAATG 101 CCGTTTTGAATCACGAAGCG CGGCGCGGTG GCAACACCTT CCGCATCAAA 151 ATAGCTGCTG CGGAAAGAGCGGGGGATGTG CGGTTCTTCG CGCAGGTTGA 201 GGAAATCGGG CAGGACTTTT TTGCCGATGCTGTCGATCAG GAAACTGCTT 251 TGGCGGTAGA GCGCGCCGCC GGAGAGTGTG CCGACGAGGTGTCCGATCAG 301 CCCGCCCGAA ACGGTGGTAT CGAAGAGGAC GGGGTAGCTG CCTGTCGGGA351 TGCTGCGGCT GCCGAGTCGG CGCAAAGTGC GGCGGGCGGC GGTTTGACCG 401ATGGTTTCGG GGCTGTCCAT ATCCGGATGG CGGCAGGCGG AATCGTACCA 451 GTAGTCGCGCTGCATTCCGT TTTCGTCGGC GGCAACGACG CTGCAGGAAA 501 TGCTGTGGTG CGTGCTTTGCCGGTGTGCGG CAAAACCGTG GGTGTTGCCG 551 TAAACGTATT GGTAGTGTCC GGTTTGCACCGCCGCGCCTT CGGAGTTTTC 601 GATGCGGCTG TCCGTGTCCA ACGCTGCCTG TTCGCATTGTTTTGCCAAGC 651 CGACGGCGGC TTCCGTATCC AAATCCCATT CGTGGTAAAG GTCGGGGTCG701 CCGATGTGTT GCGCCATCAA CTCGGGGTCG GCAAGTCCGG CGCAACCGTC 751TTCGGCGGTG TGGCGGGCGA TGTCGGCGGC GGCGCGGACG GTGTCGCGCA 801 GGGCTTGTTCGGAGAAGTCG GCGGTGCCGG CGCGGCCTTT GCGTTTGCCG 851 ACGTAAACGG TAATGTCCAGCGATTTGTCC TGCTGGAACT CGATTTGTTC 901 GATTTCGCCC AAGCGCACGC TGACGCTTTGTCCGAGCGAT TCGCTGAAGT 951 CGGCTTCGGC GGCGGTCGCG CCCGCTGCTT TTGCCAAGTCGAGCGTGCGG 1001 CGGCAGAGGT CGAGGAGTTC GGAAGCGGTG TGGTTGAACA GCATAACAAT1051 CTTTCTTGGT GGAGCGTTGT GGCATTTTAAThis corresponds to the amino acid sequence <SEQ ID 1424; ORF 515-1.ng>:

g515-1.pep 1 MVQIQVVRAA GVARGLHSEF ARAVTAEEIA FDNAVLNHEA RRGGNTFRIK 51IAAAERAGDV RFFAQVEEIG QDFFADAVDQ ETALAVERAA GECADEVSDQ 101 PARNGGIEEDGVAACRDAAA AESAQSAAGG GLTDGFGAVH IRMAAGGIVP 151 VVALHSVFVG GNDAAGNAVVRALPVCGKTV GVAVNVLVVS GLHRRAFGVF 201 DAAVRVQRCL FALFCQADGG FRIQIPFVVKVGVADVLRHQ LGVGKSGATV 251 FGGVAGDVGG GADGVAQGLF GEVGGAGAAF AFADVNGNVQRFVLLELDLF 301 DFAQAHADAL SERFAEVGFG GGRARCFCQV ERAAAEVEEF GSGVVEQHNN351 LSWWSVVAF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1425>:

m515-1.seq 1 ATGGTTCAAA TACAGGTTGT GCGCGCCGCC GGCGTTGCCC GTGGTCTGCA 51TACCGAGTTT GCGCGCGCTG TAACTGCTGA GGAAATAGCC TTCGACAATG 101 CCGTTTTGAATCACGAAGCG CGGTGCGGTG GCAACGCCTT CCGCATCAAA 151 ATAGCTGCTG CGGAAAGAGCGGGGGATGTG CGGTTCTTCG CGCAGGTTGA 201 GGAAATCGGG CAGGACTTTT TTGCCGATGCTGTCGATCAG GAAACTGCTT 251 TGGCGGTAGA GCGCGCCGCC GGAGAGTGCG CCGACGAGGTGTCCGATAAG 301 ACCGCCCGAA ACGGTGGTAT CGAAGAGGAC GGGGTAGCTG CCTGTCGGGA351 TGCTGCGGCT GCCGAGTCGG CGCAAAGTGC GGCGGGCGGC GGTTTGACCG 401ATGGTTTCGG GGCTGTCCAT ATCCGGATGG CGGCAGGCGG AATCGTACCA 451 GTAGTCGCGCTGCATGCCGT TTTCGTCGGC GGCAACGACG CTGCAGGAAA 501 TGCTGTGGTG CGTGCCTTGCCGGTGTGCGG CAAAACCGTG GGTGTTGCCG 551 TAAACGTATT GGTAATGGCC GGTTTGCACCGCCGCGCCTT CGGAGTTTTC 601 GATGCGCTCA TCCTCGTTCA GGGCGGCTTG TTCGCATTGTTTTGCCAAGC 651 CGACGGCGGC TTCCGTATCC AAATCCCATT CGTGGTAAAG GTCGGGGTCG701 CCGATGTGTT TTGCCATCAG ACAGGCATCG GCAAGTCCGG CGCAACCGTC 751TTCGGCGGTG TGGCGGGCGA TGTCGATGGC GGCTTTGACG GTGTCTTGCA 801 GGGCTTTTTCGGAGAAGTCG GCAGTACTGG CGCGGCCTTT GCGTTTGCCG 851 ACGTAAACGG TAATGTCCAGCGACTTGTCC TGCTGGAACT CGATTTGTTC 901 GATTTCGCCC AGCCGCACGC TGACGCTTTGTCCCAATGAThis corresponds to the amino acid sequence <SEQ ID 1426; ORF 515-1>:

m515-1.pep 1 MVQIQVVRAA GVARGLHTEF ARAVTAEEIA FDNAVLNHEA RCGGNAFRIK 51IAAAERAGDV RFFAQVEEIG QDFFADAVDQ ETALAVERAA GECADEVSDK 101 TARNGGIEEDGVAACRDAAA AESAQSAAGG GLTDGFGAVH IRMAAGGIVP 151 VVALHAVFVG GNDAAGNAVVRALPVCGKTV GVAVNVLVMA GLHRRAFGVF 201 DALILVQGGL FALFCQADGG FRIQIPFVVKVGVADVFCHQ TGIGKSGATV 251 FGGVAGDVDG GFDGVLQGFF GEVGSTGAAF AFADVNGNVQRLVLLELDLF 301 DFAQPHADAL SQ* m515-1/g515-1 91.7% identity in 312 aaoverlap         10        20        30        40        50        60g515-1.pep MVQIQVVRAAGVARGLHSEFARAVTAEEIAFDNAVLNHEARRGGNTFRIKIAAAERAGDV|||||||||||||||||:||||||||||||||||||||||| |||:|||||||||||||| m515-1MVQIQVVRAAGVARGLHTEFARAVTAEEIAFDNAVLNHEARCGGNAFRIKIAAAERAGDV        10        20        30        40        50        60        70        80        90       100       110       120 g515-1.pepRFFAQVEEIGQDFFADAVDQETALAVERAAGECADEVSDQPARNGGIEEDGVAACRDAAA|||||||||||||||||||||||||||||||||||||||: ||||||||||||||||||| m515-1RFFAQVEEIGQDFFADAVDQETALAVERAAGECADEVSDKTARNGGIEEDGVAACRDAAA        70        80        90       100       110       120       130       140       150       160       170       180 g515-1.pepAESAQSAAGGGLTDGFGAVHIRMAAGGIVPVVALHSVFVGGNDAAGNAVVRALPVCGKTV|||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| m515-1AESAQSAAGGGLTDGFGAVHIRMAAGGIVPVVALHAVFVGGNDAAGNAVVRALPVCGKTV       130       140       150       160       170       180       190       200       210       220       230       240 g515-1.pepGVAVNVLVVSGLHRRAFGVFDAAVRVQRCLFALFCQADGGFRIQIPFVVKVGVADVLRHQ||||||||::|||||||||||| : ||  |||||||||||||||||||||||||||: || m515-1GVAVNVLVMAGLHRRAFGVFDALILVQGGLFALFCQADGGFRIQIPFVVKVGVADVFCHQ       190       200       210       220       230       240       250       260       270       280       290       300 g515-1.pepLGVGKSGATVFGGVAGDVGGGADGVAQGLFGEVGGAGAAFAFADVNGNVQRFVLLELDLF |:||||||||||||||| || ||| ||:|||||::|||||||||||||||:|||||||| m515-1TGIGKSGATVFGGVAGDVDGGFDGVLQGFFGEVGSTGAAFAFADVNGNVQRLVLLELDLF       250       260       270       280       290       300       310       320       330       340       350       360 g515-1.pepDFAQAHADALSERFAEVGFGGGRARCFCQVERAAAEVEEFGSGVVEQHNNLSWWSVVAFX|||| ||||||: m515-1 DFAQPHADALSQX        310The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1427>:

a515-1.seq 1 ATGGTTCAAA TAAAGGTTGT GCGCGCCGCC GGCGTTGCCC GTGGTCTGCA 51TTCCGAGTTT GCGCGCGCTG TAACTGCTGA GGAAATAGCC TTCGACAATG 101 CCGTTTTGAATCACGAAGCG CGGTGCGGTG GCAACGCCTT CCGCATCAAA 151 ATAGCTGCTG CGGAAAGAGCGGGGGATGTG CGGTTCTTCG CGCAGGTTGA 201 GGAAATCGGG CAGGACTTTT TTGCCGATGCTGTCGATCAG GAAACTGCTT 251 TGGCGGTAGA GCGCTCCGCC GGAGAGTGCG CCGACGAGGTGTCCGATAAG 301 ACCGCCCGAA ACGGTGGTAT CGAAGAGGAC GGGGTAGTTG CCTGTCGGGA351 TGCTGCGGCT GCCGAGTCGG CGCAAAGTGC GGCGGGCGGC GGTTTGACCG 401ATGGTTTCGG GGCTGTCCAT ATCCGGATGG CGGCAGGCGG AATCGTACCA 451 GTAGTCGCGCTGCATGCCGT TTTCGTCGGC GGCAACGACG CTGCAGGAAA 501 TGCTGTGGTG CGTGCTTTGCCGGTGTGCGG CAAAACCGTA GGTGTTGCCG 551 TAAACGTATT GGTAATGGCC GGTTTGCACCGCCGCGCCTT CGGAGTTTTC 601 GATGCGCTCA TCCTCGTTCA GGGCGGCTTG TTCGCATTGTTTTGCCAAGC 651 CGACGGCGGC TTCCGTATCC AAATCCCATT CGTGGTAAAG GTCGGGGTCG701 CCGATGTGTT GCGCCATCAA CTCGGGGTCG GCAAGTCCGG CGCAACCGTC 751TTCGGCGGTG TGGCGGGCGA TGTCGGCGGC GGCGCGGACG GTGTCGCGCA 801 GGGCTTGTTCGGAGAAATCG GCGGTGCCGG CGCGGCCTTT GCGTTTGCCG 851 ACGTAAACGG TAATGTCCAGCGACTTGTCC TGCTGAAACT CGATTTGTTC 901 GATTTCGCCC AGCCGCACGC TGACGCTTTGTCCCAATGAThis corresponds to the amino acid sequence <SEQ ID 1428; ORF 515-1.a>:

a515-1.pep 1 MVQIKVVRAA GVARGLHSEF ARAVTAEEIA FDNAVLNHEA RCGGNAFRIK 51IAAAERAGDV RFFAQVEEIG QDFFADAVDQ ETALAVERSA GECADEVSDK 101 TARNGGIEEDGVVACRDAAA AESAQSAAGG GLTDGFGAVH IRMAAGGIVP 151 VVALHAVFVG GNDAAGNAVVRALPVCGKTV GVAVNVLVMA GLHRRAFGVF 201 DALILVQGGL FALFCQADGG FRIQIPFVVKVGVADVLRHQ LGVGKSGATV 251 FGGVAGDVGG GADGVAQGLF GEIGGAGAAF AFADVNGNVQRLVLLKLDLF 301 DFAQPHADAL SQ* m515-1/a515-1 94.9% identity in 312 aaoverlap         10        20        30        40        50        60a515-1.pep MVQIKVVRAAGVARGLHSEFARAVTAEEIAFDNAVLNHEARCGGNAFRIKIAAAERAGDV||||:||||||||||||:|||||||||||||||||||||||||||||||||||||||||| m515-1MVQIQVVRAAGVARGLHTEFARAVTAEEIAFDNAVLNHEARCGGNAFRIKIAAAERAGDV        10        20        30        40        50        60        70        80        90       100       110       120 a515-1.pepRFFAQVEEIGQDFFADAVDQETALAVERSAGECADEVSDKTARNGGIEEDGVVACRDAAA||||||||||||||||||||||||||||:|||||||||||||||||||||||:||||||| m515-1RFFAQVEEIGQDFFADAVDQETALAVERAAGECADEVSDKTARNGGIEEDGVAACRDAAA        70        80        90       100       110       120       130       140       150       160       170       180 a515-1.pepAESAQSAAGGGLTDGFGAVHIRMAAGGIVPVVALHAVFVGGNDAAGNAVVRALPVCGKTV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m515-1AESAQSAAGGGLTDGFGAVHIRMAAGGIVPVVALHAVFVGGNDAAGNAVVRALPVCGKTV       130       140       150       160       170       180       190       200       210       220       230       240 a515-1.pepGVAVNVLVMAGLHRRAFGVFDALILVQGGLFALFCQADGGFRIQIPFVVKVGVADVLRHQ||||||||||||||||||||||||||||||||||||||||||||||||||||||||: || m515-1GVAVNVLVMAGLHRRAFGVFDALILVQGGLFALFCQADGGFRIQIPFVVKVGVADVFCHQ       190       200       210       220       230       240       250       260       270       280       290       300 a515-1.pepLGVGKSGATVFGGVAGDVGGGADGVAQGLFGEIGGAGAAFAFADVNGNVQRLVLLKLDLF |:||||||||||||||| || ||| ||:|||:|::|||||||||||||||||||:|||| m515-1TGIGKSGATVFGGVAGDVDGGFDGVLQGFFGEVGSTGAAFAFADVNGNVQRLVLLELDLF       250       260       270       280       290       300        310a515-1.pep DFAQPHADALSQX ||||||||||||| m515-1 DFAQPHADALSQX        310The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1429>:

g516.seq 1 atgttgttcc gtaaaacgac cgccgccgtt ttggcggcaa ccttgatact 51gaacggctgt acgatgatgt tgcgggggat gaacaacccg gtcagccaaa 101 caatcacccgcaaacacgtt gacaaagacc aaatccgcgc cttcggtgtg 151 gttgccgaag acaatgcccaattggaaaag ggcagcctgg tgatgatggg 201 cgggaaatac tggttcgccg tcaatcccgaagattcggcg aagctgacgg 251 gccttttgaa ggccgggttg gacaagccct tccaaatagttgaggatacc 301 ccgagctatg cccgccacca agccctgccg gtcaaattcg aagcgcccgg351 cagccagaat ttcagtaccg gaggtctttg cctgcgctat gataccggca 401gacctgacga catcgccaag ctgaaacagc ttgagtttaa agcggtcaaa 451 ctcgacaatcggaccattta cacgcgctgc gtatccgcca aaggcaaata 501 ctacgccacg ccgcaaaaactgaacgccga ttatcatttt gagcaaagtg 551 tgcccgccga tatttattat acggttactgaaaaacatac cgacaaatcc 601 aagctgtttg gaaatatctt atatacgccc cccttgttgatattggatgc 651 ggcggccgcg gtgctggtct tgcctatggc tctgattgca gccgcgaatt701 cctcagacaa atgaThis corresponds to the amino acid sequence <SEQ ID 1430; ORF 516.ng>:

g516.pep 1 MLFRKTTAAV LAATLILNGC TMMLRGMNNP VSQTITRKHV DKDQIRAFGV 51VAEDNAQLEK GSLVMMGGKY WFAVNPEDSA KLTGLLKAGL DKPFQIVEDT 101 PSYARHQALPVKFEAPGSQN FSTGGLCLRY DTGRPDDIAK LKQLEFKAVK 151 LDNRTIYTRC VSAKGKYYATPQKLNADYHF EQSVPADIYY TVTEKHTDKS 201 KLFGNILYTP PLLILDAAAA VLVLPMALIAAANSSDK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1431>:

m516.seq 1 ATGTTGTTCC GTAAAACGAC CGCCGCCGTT TTGGCGGCAA CCTTGATGCT 51GAACGGCTGT ACGTTGATGT TGTGGGGAAT GAACAACCCG GTCAGCGAAA 101 CAATCACCCGCAAACACGTT GACAAAGACC AAATCCGCGC CTTCGGTGTG 151 GTTGCCGAAG ACAATGCCCAATTGGAAAAG GGCAGCCTGG TGATGATGGG 201 CGGAAAATAC TGGTTCGTCG TCAATCCCGAAGATTCGGCG AAGCTGACGG 251 GCATTTTGAA GGCAGGGCTG GACAAACCCT TCCAAATAGTTGAGGATACC 301 CCGAGCTATG CTCGCCACCA AGCCCTGCCG GTCAAACTCG AATCGCCTGG351 CAGCCAGAAT TTCAGTACCG AAGGCCTTTG CCTGCGCTAC GATACCGACA 401AGCCTGCCGA CATCGCCAAG CTGAAACAGC TCGGGTTTGA AGCGGTCAAA 451 CTCGACAATCGGACCATTTA CACGCGCTGC GTATCCGCCA AAGGCAAATA 501 CTACGCCACA CCGCAAAAACTGAACGCCGA TTACCATTTT GAGCAAAGTG 551 TGCCTGCCGA TATTTATTAC ACGGTTACTGAAGAACATAC CGACAAATCC 601 AAGCTGTTTG CAAATATCTT ATATACGCCC CCCTTTTTGATACTGGATGC 651 GGCGGGCGCG GTACTGGCCT TGCCTGCGGC GGCTCTGGGT GCGGTCGTGG701 ATGCCGCCCG CAAATGAThis corresponds to the amino acid sequence <SEQ ID 1432; ORF 516>:

m516.pep 1 MLFRKTTAAV LAATLMLNGC TLMLWGMNNP VSETITRKHV DKDQIRAFGV 51VAEDNAQLEK GSLVMMGGKY WFVVNPEDSA KLTGILKAGL DKPFQIVEDT 101 PSYARHQALPVKLESPGSQN FSTEGLCLRY DTDKPADIAK LKQLGFEAVK 151 LDNRTIYTRC VSAKGKYYATPQKLNADYHF EQSVPADIYY TVTEEHTDKS 201 KLFANILYTP PFLILDAAGA VLALPAAALGAVVDAARK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 516 shows 90.0% identity over a 231 aa overlap with a predicted ORF(ORF 516.ng) from N. gonorrhoeae:

m516/g516         10        20        30        40        50        60m516.pep MLFRKTTAAVLAATLMLNGCTLMLWGMNNPVSETITRKHVDKDQIRAFGVVAEDNAQLEK|||||||||||||||:|||||:|| |||||||:||||||||||||||||||||||||||| g516MLFRKTTAAVLAATLILNGCTMMLRGMNNPVSQTITRKHVDKDQIRAFGVVAEDNAQLEK        10        20        30        40        50        60        70        80        90       100       110       120 m516.pepGSLVMMGGKYWFVVNPEDSAKLTGILKAGLDKPFQIVEDTPSYARHQALPVKLESPGSQN||||||||||||:|||||||||||:|||||||||||||||||||||||||||:|:||||| g516GSLVMMGGKYWFAVNPEDSAKLTGLLKAGLDKPFQIVEDTPSYARHQALPVKFEAPGSQN        70        80        90       100       110       120       130       140       150       160       170       180 m516.pepFSTEGLCLRYDTDKPADIAKLKQLGFEAVKLDNRTIYTRCVSAKGKYYATPQKLNADYHF||| |||||||| :| |||||||| |:||||||||||||||||||||||||||||||||| g516FSTGGLCLRYDTGRPDDIAKLKQLEFKAVKLDNRTIYTRCVSAKGKYYATPQKLNADYHF       130       140       150       160       170       180       190       200       210       220       230       239 m516.pepEQSVPADIYYTVTEEHTDKSKLFANILYTPPFLILDAAGAVLALPAAALGAVVDAARK||||||||||||||:||||||||:|||||||:||||||:|||:|| | ::|: g516EQSVPADIYYTVTEKHTDKSKLFGNILYTPPLLILDAAAAVLVLPMALIAAANSSDK       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1433>:

a516.seq 1 ATGTTGTTCC GTAAAACGAC CGCCGCCGTT TTGGCGGCAA CCTTGATGTT 51GAACGGCTGT ACGGTAATGA TGTGGGGTAT GAACAGCCCG TTCAGCGAAA 101 CGACCGCCCGCAAACACGTT GACAAGGACC AAATCCGCGC CTTCGGTGTG 151 GTTGCCGAAG ACAATGCCCAATTGGAAAAG GGCAGCCTGG TGATGATGGG 201 CGGGAAATAC TGGTTCGTCG TCAATCCTGAAGATTCGGCG AAGCTGACGG 251 GCATTTTGAA GGCCGGGTTG GACAAGCAGT TTCAAATGGTTGAGCCCAAC 301 CCGCGCTTTG CCTACCAAGC CCTGCCGGTC AAACTCGAAT CGCCCGCCAG351 CCAGAATTTC AGTACCGAAG GCCTTTGCCT GCGCTACGAT ACCGACAGAC 401CTGCCGACAT CGCCAAGCTG AAACAGCTTG AGTTTGAAGC GGTCGAACTC 451 GACAATCGGACCATTTACAC GCGCTGCGTC TCCGCCAAAG GCAAATACTA 501 CGCCACACCG CAAAAACTGAACGCCGATTA TCATTTTGAG CAAAGTGTGC 551 CTGCCGATAT TTATTACACG GTTACGAAAAAACATACCGA CAAATCCAAG 601 TTGTTTGAAA ATATTGCATA TACGCCCACC ACGTTGATACTGGATGCGGT 651 GGGCGCGGTG CTGGCCTTGC CTGTCGCGGC GTTGATTGCA GCCACGAATT701 CCTCAGACAA ATGAThis corresponds to the amino acid sequence <SEQ ID 1434; ORF 516.a>:

a516.pep 1 MLFRKTTAAV LAATLMLNGC TVMMWGMNSP FSETTARKHV DKDQIRAFGV 51VAEDNAQLEK GSLVMMGGKY WFVVNPEDSA KLTGILKAGL DKQFQMVEPN 101 PRFAYQALPVKLESPASQNF STEGLCLRYD TDRPADIAKL KQLEFEAVEL 151 DNRTIYTRCV SAKGKYYATPQKLNADYHFE QSVPADIYYT VTKKHTDKSK 201 LFENIAYTPT TLILDAVGAV LALPVAALIAATNSSDK* m516/a516 86.1% identity in 238 aa overlap          10        20        30        40        50        60 m516.pep  MLFRKTTAAVLAATLMLNGCTLMLWGMNNPVSETITRKHVDKDQIRAFGVVAEDNAQLEK  |||||||||||||||||||||:|:||||:| ||| :|||||||||||||||||||||||| a516  MLFRKTTAAVLAATLMLNGCTVMMWGMNSPFSETTARKHVDKDQIRAFGVVAEDNAQLEK          10        20        30        40        50        60          70        80        90       100       110       120 m516.pep  GSLVMMGGKYWFVVNPEDSAKLTGILKAGLDKPFQIVEDTPSYARHQALPVKLESPGSQN  |||||||||||||||||||||||||||||||| ||:|| :| :| :||||||||||:||| a516  GSLVMMGGKYWFVVNPEDSAKLTGILKAGLDKQFQMVEPNPRFA-YQALPVKLESPASQN          70        80        90        100       110         130       140       150       160       170       180 m516.pep  FSTEGLCLRYDTDKPADIAKLKQLGFEAVKLDNRTIYTRCVSAKGKYYATPQKLNADYHF  |||||||||||||:|||||||||| ||||:|||||||||||||||||||||||||||||| a516  FSTEGLCLRYDTDRPADIAKLKQLEFEAVELDNRTIYTRCVSAKGKYYATPQKLNADYHF120       130       140       150       160       170         190       200       210       220       230      239 m516.pep  EQSVPADIYYTVTEEHTDKSKLFANILYTPPFLILDAAGAVLALPAAALGAVVDAARKX  |||||||||||||::|||||||| || |||  |||||:|||||||:||| |::::: || a516  EQSVPADIYYTVTKKHTDKSKLFENIAYTPTTLILDAVGAVLALPVAALIAATNSSDKX180       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1435>:

g517.seq 1 atgcatcggg tttcagacgg cattggagtg tcagtcgtgt tctgccgatt 51cgtaggcttc gacgattttt tgcaccagag gatgccggac aacgtcttcg 101 ccggtgaaggtatggaaata cagtcctgcc acgccgtgca gtttctcacg 151 tgcgtctttc aatcccgatttgatgttttt gggcaggtcg atttggctgg 201 tgtcgccggt aatgacggct ttcgcgccgaagccgatgcg ggtcaggaac 251 attttcattt gttcgggcgt ggtgttttgc gcttcgtcgaggatgatgta 301 tgcgccgttg agcgtcctgc cgcgcatata ggcgagcggg gcgatttcaa351 tcaggccttt ttcaatcagc ttggttacac ggtcaaagcc catcaggtca 401tagagggcat cataaagcgg acggaggtag gggtcgactt tttgggtcag 451 gtctccgggcaggaagccca gtttctcacc ggcttcgacg gcaggccgaa 501 ctaaThis corresponds to the amino acid sequence <SEQ ID 1436; ORF 517.ng>:

g517.pep 1 MHRVSDGIGV SVVFCRFVGF DDFLHQRMPD NVFAGEGMEI QSCHAVQFLT 51CVFQSRFDVF GQVDLAGVAG NDGFRAEADA GQEHFHLFGR GVLRFVEDDV 101 CAVERPAAHIGERGDFNQAF FNQLGYTVKA HQVIEGIIKR TEVGVDFLGQ 151 VSGQEAQFLT GFDGRPN*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1437>:

m517.seq 1 ATGCATCGGG TTTCAGACGG CATTGGAATG TCAGTCGTGT TCTGCCGATT 51CGTAGGCTTC GACGATTTTT TGCACCAAAG GATGCCGGAC AACGTCTTCG 101 CCGGTAAAGGTGTGGAAATA CAGCCCTTCC ACGTTGTGCA GTTTCTCACG 151 CGCATCTTTT AATCCCGATTTGATGTTTTT GGGCAGGTCG ATTTGGCTGG 201 TGTCGCCGGT AATGACGGCT TTCGCGCCGAAGCCGATGCG GGTCAGGAAC 251 ATTTTCATTT GTTCGGGCGT GGTGTTTTGC GCTTCGTCGAGGATGATGTA 301 TGCGCCGTTG AGCGTCCTGC CGCGCATATA GGCGAGCGGG GCGATTTCAA351 TCAGGCCTTT TTCAATCAGC TTGGTTACAC GGTCAAAGCC CATCAGGTCA 401TAGAGGGCAT CATAAAGCGG ACGAAGGTAG GGATCGACTT TCTGGGTCAG 451 GTCTCCGGGCAGGAAGCCCA GTTTCTCGCC GGCTTCGACG GCTGgGCGCA 501 CTAAThis corresponds to the amino acid sequence <SEQ ID 1438; ORF 517>:

m517.pep 1 MHRVSDGIGM SVVFCRFVGF DDFLHQRMPD NVFAGKGVEI QPFHVVQFLT 51RIFXSRFDVF GQVDLAGVAG NDGFRAEADA GQEHFHLFGR GVLRFVEDDV 101 CAVERPAAHIGERGDFNQAF FNQLGYTVKA HQVIEGIIKR TKVGIDFLGQ 151 VSGQEAQFLA GFDGWAH*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 517 shows 92.7% identity over a 164 aa overlap with a predicted ORF(ORF 517.ng) from N. gonorrhoeae:

m517/g517         10        20        30        40        50        60m517.pep MHRVSDGIGMSVVFCRFVGFDDFLHQRMPDNVFAGKGVEIQPFHVVQFLTRIFXSRFDVF|||||||||:|||||||||||||||||||||||||:|:|||  |:||||| :| |||||| g517MHRVSDGIGVSVVFCRFVGFDDFLHQRMPDNVFAGEGMEIQSCHAVQFLTCVFQSRFDVF        10        20        30        40        50        60        70        80        90       100       110       120 m517.pepGQVDLAGVAGNDGFRAEADAGQEHFHLFGRGVLRFVEDDVCAVERPAAHIGERGDFNQAF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g517GQVDLAGVAGNDGFRAEADAGQEHFHLFGRGVLRFVEDDVCAVERPAAHIGERGDFNQAF        70        80        90       100       110       120       130       140       150       160 m517.pepFNQLGYTVKAHQVIEGIIKRTKVGIDFLGQVSGQEAQFLAGFDGWAH|||||||||||||||||||||:||:||||||||||||||:|||| g517FNQLGYTVKAHQVIEGIIKRTEVGVDFLGQVSGQEAQFLIGFDGRPN       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1439>:

a517.seq 1 ATGCATCGGG TTTCAGACGG CATTGGAATG TCAGTCGTGT TCTGCCGATT 51CGTAGGCTTC GACGATTTTT TGCACCAAAG GATGCCGGAC AACGTCTTCG 101 CCGGTAAAGGTGTGGAAATA CAGCCCTTCC ACGCCGTGCA GTTTCTCACG 151 CGCATCTTTT AATCCCGATTTGATGTTTTT GGGCAGGTCG ATTTGGCTGG 201 TGTCGCCGGT AATGACGGCT TTCGCGCCGAAGCCGATGCG GGTCAGGAAC 251 ATTTTCATTT GTTCGGGCGT GGTGTTTTGC GCTTCGTCGAGGATGATGTA 301 TGCGCCGTTG AGCGTCCTGC CGCGCATATA GGCGAGCGGG GCAATCTCAA351 TCAGACCTTT TTCAATCAGC TTGGTGACAC GGTCGAAGCC CATCAGGTCA 401TAGAGGGCAT CATAAAGCGG ACGAAGGTAG GGATCGACTT TCTGGGTCAG 451 GTCACCGGGCAGAAAACCCA GTTTCTCGCC GGCTTCGACG GCAGGCCGCA 501 CTAAThis corresponds to the amino acid sequence <SEQ ID 1440; ORF 517.a>:

a517.pep 1 MHRVSDGIGM SVVFCRFVGF DDFLHQRMPD NVFAGKGVEI QPFHAVQFLT 51RIF*SRFDVF GQVDLAGVAG NDGFRAEADA GQEHFHLFGR GVLRFVEDDV 101 CAVERPAAHIGERGNLNQTF FNQLGDTVEA HQVIEGIIKR TKVGIDFLGQ 151 VTGQKTQFLA GFDGRPH*m517/a517 93.4% identity in 167 aa overlap        10        20        30        40        50        60 m517.pepMHRVSDGIGMSVVFCRFVGFDDFLHQRMPDNVFAGKGVEIQPFHVVQFLTRIFXSRFDVF||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||| a517MHRVSDGIGMSVVFCRFVGFDDFLHQRMPDNVFAGKGVEIQPFHAVQFLTRIFXSRFDVF        10        20        30        40        50        60        70        80        90       100       110       120 m517.pepGQVDLAGVAGNDGFRAEADAGQEHFHLFGRGVLRFVEDDVCAVERPAAHIGERGDFNQAF||||||||||||||||||||||||||||||||||||||||||||||||||||||::||:| a517GQVDLAGVAGNDGFRAEADAGQEHFHLFGRGVLRFVEDDVCAVERPAAHIGERGNLNQTF        70        80        90       100       110       120       130       140       150       160 m517.pepFNQLGYTVKAHQVIEGIIKRTKVGIDFLGQVSGQEAQFLAGFDGWAHX||||| ||:||||||||||||||||||||||:||::||||||||  || a517FNQLGDTVEAHQVIEGIIKRTKVGIDFLGQVTGQKTQFLAGFDGRPHX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1441>:

g518.seq 1 atgacgtttt cggcggcaaa gctcaacatt tcggcactga tgttgtgtct 51ttcggcagga atgaccgttt tactttccgc ttttttactg ctccgaccgg 101 aaggcagcatcttattcaac cattttttca gcataaatat tctgacccga 151 agagcggcat ctccacgggcaaccgtgttc agactgcatc aggcggtacg 201 attccacaag atgccgaaaa ccataagcaaaatgcgtaga aactacgccg 251 tccgaatcac gccgcctcct cgggcggcaa cgcttcattataacagattg 301 ccccttaaaa aatcagaccc tgcttttgtg gcggagtctg aaatttgaThis corresponds to the amino acid sequence <SEQ ID 1442; ORF 518.ng>:

g518.pep 1 MTFSAAKLNI SALMLCLSAG MTVLLSAFLL LRPEGSILFN HFFSINILTR 51RAASPRATVF RLHQAVRFHK MPKTISKMRR NYAVRITPPP RAATLHYNRL 101 PLKKSDPAFVAESEI*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1443>:

m518.seq 1 ATGACGTTTT CGGCGGCAAA GCTCAACATT TCGGCACGGA TGTTGTGTCT 51TTCGGCAGGA ATGACCGTTT TACTTTCCGC TTTTTTACTG CTCCGACCGG 101 AAGGCAGCATCTTATTCAAC CATTTTTTCA GCATAAATAT TCTGACCCGA 151 AGAGCGGCAT CTCCACAGGCAACCGTGTTC AGACGGCATC AGGCGCGGTT 201 TGCAAGATGC CGTACCATAA ACAAAAGGCGTAGAAACTAC GCCGTCCGAA 251 TCACGCCGCC CTCGCG.GCG GCAACGCGTC ATTATAACAGATTGCCCTCC 301 GCGGCAGGCT TAGTGCGGCG GGAGCGCCGC CGTTGCGCAG TAATATTGTC351 TAACGGGAGG AAAAAATCAG ACCCTGCTTT TGTGGCAGAG TCTGAAATTT 401 GAThis corresponds to the amino acid sequence <SEQ ID 1444; ORF 518>:

m518.pep 1 MTFSAAKLNI SARMLCLSAG MTVLLSAFLL LRPEGSILFN HFFSINILTR 51RAASPQATVF RRHQARFARC RTINKRRRNY AVRITPPSXA ATRHYNRLPS 101 AAGLVRRERRRCAVILSNGR KKSDPAFVAE SEI*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 518 shows 74.1% identity over a 135 aa overlap with a predicted ORF(ORF 518.ng) from N. gonorrhoeae:

m518/g518 m518.pep MTFSAAKLNISARMLCLSAGMTVLLSAFLLLRPEGSILFNHFFSINILTRRAASPQATVF |||||||||||| ||||||||||||||||||||||||||||||||||||||||||:|||| g518 MTFSAAKLNISALMLCLSAGMTVLLSAFLLLRPEGSILFNHFFSINILTRRAASPRATVF         10        20        30        40        50        60          70         80        90       100       110 m518.pep RRHQA-RFARC-RTINKRRRNYAVRITPPSXAATRHYNRLPSAAGLVRRERRRCAVILSN | ||| || :  :||:| |||||||||||  ||| |||||| g518 RLHQAVRFHKMPKTISKMRRNYAVRITPPPRAATLHYNRLPL------------------         70        80        90       100 120       130 m518.pep GRKKSDPAFVAESEI    ||||||||||||| g518  --KKSDPAFVAESEI         110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1445>:

a518.seq 1 ATGACGTTTT CGGCGGCAAA GCTCAACATT TCGGCACGGA TGTTGTGTCT 51TTCGGCAGGA ATGACCGTTT TACTTTCCGC TTTTTTACTG CTCCGACCGG 101 AAGGCAGCATCTTATTCAAC CATTTTTTCA GCATAAATAT TCTAACCCGA 151 AGAGCGGCAT CTCCACGGGCAACCGTGTTC AGACGGCATC AGGCGGTACG 201 ATTCCGCAAG ATGCCGACCA TAAACAAAAGGCGTAGAAAC TACGCCGTCC 251 GAATCACGCC GTCCTCG.CG GCGGCAACGC GTCATTATAACAGATTGCCC 301 TCC....... .......... .......... .......... ..........351 .......... ...AAAAAAT CAGACCCTGC TTTTGTGGCA GAGTCTGAAA 401 TTTGAThis corresponds to the amino acid sequence <SEQ ID 1446; ORF 518.a>:

a518.pep 1 MTFSAAKLNI SARMLCLSAG MTVLLSAFLL LRPEGSILFN HFFSINILTR 51RAASPRATVF RRHQAVRFRK MPTINKRRRN YAVRITPSSX AATRHYNRLP 101 S................... .KKSDPAFVA ESEI* m518/a518 79.9% identity in 134 aa overlap          10        20        30        40        50        60 m518.pep  MTFSAAKLNISARMLCLSAGMTVLLSAFLLLRPEGSILFNHFFSINILTRRAASPQATVF  |||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||| a518  MTFSAAKLNISARMLCLSAGMTVLLSAFLLLRPEGSILFNHFFSINILTRRAASPRATVF          10        20        30        40        50        60           70        80        90       100       110      119 m518.pep  RRHQA-RFARCRTINKRRRNYAVRITPPSXAATRHYNRLPSAAGLVRRERRRCAVILSNG  ||||| || :  ||||||||||||||| ||||||||||||| a518  RRHQAVRFRKMPTINKRRRNYAVRITPSSXAATRHYNRLPS-------------------          70        80        90       100 120       130 m518.pep  RKKSDPAFVAESEIX    |||||||||||||| a518   -KKSDPAFVAESEIX          110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1447>:

g519.seq 1 atggaatttt tcattatctt gttggcagcc gtcgccgttt tcggcttcaa 51atcctttgtc gtcatccccc agcaggaagt ccacgttgtc gaaaggctcg 101 ggcgtttccatcgcgccctg acggccggtt tgaatatttt gattcccttt 151 atcgaccgcg tcgcctaccgccattcgctg aaagaaatcc ctttagacgt 201 acccagccag gtctgcatca cgcgcgataatacgcaattg actgttgacg 251 gcatcatcta tttccaagta accgatccca aactcgcctcatacggttcg 301 agcaactaca ttatggcaat tacccagctt gcccaaacga cgctgcgttc351 cgttatcggg cgtatggagt tggacaaaac gtttgaagaa cgcgacgaaa 401tcaacagtac cgtcgtctcc gccctcgatg aagccgccgg ggcttggggt 451 gtgaaagtcctccgttacga aatcaaggat ttggttccgc cgcaagaaat 501 ccttcgcgca atgcaggcacaaattaccgc cgaacgcgaa aaacgcgccc 551 gtattgccga atccgaaggc cgtaaaatcgaacaaatcaa ccttgccagt 601 ggtcagcgtg aagccgaaat ccaacaatcc gaaggcgaggctcaggctgc 651 ggtcaatgcg tccaatgccg agaaaatcgc ccgcatcaac cgcgccaaag701 gcgaagcgga atccctgcgc cttgttgccg aagccaatgc cgaagccaac 751cgtcaaattg ccgccgccct tcaaacccaa agcggggcgg atgcggtcaa 801 tctgaagattgcgggacaat acgttaccgc gttcaaaaat cttgccaaag 851 aagacaatac gcggattaagcccgccaagg ttgccgaaat cgggaaccct 901 aattttcggc ggcatgaaaa attttcgccagaagcaaaaa cggccaaata 951 aThis corresponds to the amino acid sequence <SEQ ID 1448; ORF 519.ng>:

g519.pep 1 MEFFIILLAA VAVFGFKSFV VIPQQEVHVV ERLGRFHRAL TAGLNILIPF 51IDRVAYRHSL KEIPLDVPSQ VCITRDNTQL TVDGIIYFQV TDPKLASYGS 101 SNYIMAITQLAQTTLRSVIG RMELDKTFEE RDEINSTVVS ALDEAAGAWG 151 VKVLRYEIKD LVPPQEILRAMQAQITAERE KRARIAESEG RKIEQINLAS 201 GQREAEIQQS EGEAQAAVNA SNAEKIARINRAKGEAESLR LVAEANAEAN 251 RQIAAALQTQ SGADAVNLKI AGQYVTAFKN LAKEDNTRIKPAKVAEIGNP 301 NFRRHEKFSP EAKTAK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1449>:

m519.seq (partial) 1 ..TCCGTTATCG GGCGTATGGA GTTGGACAAA ACGTTTGAAGAACGCGACGA 51   AATCAACAGT ACTGTTGTTG CGGCTTTGGA CGAGGCGGCC GGGgCTTgGG101   GTGTGAAGGT TTTGCGTTAT GAGATTAAAG ACTTGGTTCC GCCGCAAGAA 151  ATCCTTCGCT CAATGCAGGC GCAAATTACT GCCGAACGCG AAAAACGCGC 201  CCGTATCGCC GAATCCGAAG GTCGTAAAAT CGAACAAATC AACCTTGCCA 251  GTGGTCAGCG CGAAGCCGAA ATCCAACAAT CCGAAGGCGA GGCTCAGGCT 301  GCGGTCAATG CGTCAAATGC CGAGAAAATC GCCCGCATCA ACCGCGCCAA 351  AGGTGAAGCG GAATCCTTGC GCCTTGTTGC CGAAGCCAAT GCCGAAGCCA 401  TCCGTCAAAT TGCCGCCGCC CTTCAAACCC AAGGCGGTGC GGATGCGGTC 451  AATCTGAAGA TTGCGGAACA ATACGTCGCT GCGTTCAACA ATCTTGCCAA 501  AGAAAGCAAT ACGCTGATTA TGCCCGCCAA TGTTGCCGAC ATCGGCAGCC 551  TGATTTCTGC CGGTATGAAA ATTATCGACA GCAGCAAAAC CGCCAAaTAAThis corresponds to the amino acid sequence <SEQ ID 1450; ORF 519>:

m519.pep (partial) 1 ..SVIGRMELDK TFEERDEINS TVVAALDEAA GAWGVKVLRYEIKDLVPPQE 51   ILRSMQAQIT AEREKRARIA ESEGRKIEQI NLASGQREAE IQQSEGEAQA101   AVNASNAEKI ARINRAKGEA ESLRLVAEAN AEAIRQIAAA LQTQGGADAV 151  NLKIAEQYVA AFNNLAKESN TLIMPANVAD IGSLISAGMK IIDSSKTAK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 519 shows 87.5% identity over a 200 aa overlap with a predicted ORF(ORF 519.ng) from N. gonorrhoeae:

m519/g519                                       10        20        30m519.pep                               SVIGRMELDKTFEERDEINSTVVAALDEAA                              |||||||||||||||||||||||:|||||| g519YFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVSALDEAA  90       100       110       120       130       140        40        50        60        70        80        90 m519.pepGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAE|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| g519GAWGVKVLRYEIKDLVPPQEILRAMQAQITAEREKRARIAESEGRKIEQINLASGQREAE 150       160       170       180       190       200       100       110       120       130       140       150 m519.pepIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAV||||||||||||||||||||||||||||||||||||||||||| ||||||||||:||||| g519IQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEANRQIAAALQTQSGADAV 210       220       230       240       250       260       160       170       180        190       200 m519.pepNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL-ISAGMKIIDSSKTAK||||| |||:||:|||||:|| | ||:||:||:  :    |:   :|||| g519NLKIAGQYVTAFKNLAKEDNTRIKPAKVAEIGNPNFRRHEKFSPEAKTAK 270       280       290       300       310The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1451>:

a519.seq 1 ATGGAATTTT TCATTATCTT GCTGGCAGCC GTCGTTGTTT TCGGCTTCAA 51ATCCTTTGTT GTCATCCCAC AGCAGGAAGT CCACGTTGTC GAAAGGCTCG 101 GGCGTTTCCATCGCGCCCTG ACGGCCGGTT TGAATATTTT GATTCCCTTT 151 ATCGACCGCG TCGCCTACCGCCATTCGCTG AAAGAAATCC CTTTAGACGT 201 ACCCAGCCAG GTCTGCATCA CGCGCGACAATACGCAGCTG ACTGTTGACG 251 GTATCATCTA TTTCCAAGTA ACCGACCCCA AACTCGCCTCATACGGTTCG 301 AGCAACTACA TTATGGCGAT TACCCAGCTT GCCCAAACGA CGCTGCGTTC351 CGTTATCGGG CGTATGGAAT TGGACAAAAC GTTTGAAGAA CGCGACGAAA 401TCAACAGCAC CGTCGTCTCC GCCCTCGATG AAGCCGCCGG AGCTTGGGGT 451 GTGAAGGTTTTGCGTTATGA GATTAAAGAC TTGGTTCCGC CGCAAGAAAT 501 CCTTCGCTCA ATGCAGGCGCAAATTACTGC TGAACGCGAA AAACGCGCCC 551 GTATCGCCGA ATCCGAAGGT CGTAAAATCGAACAAATCAA CCTTGCCAGT 601 GGTCAGCGCG AAGCCGAAAT CCAACAATCC GAAGGCGAGGCTCAGGCTGC 651 GGTCAATGCG TCAAATGCCG AGAAAATCGC CCGCATCAAC CGCGCCAAAG701 GTGAAGCGGA ATCCTTGCGC CTTGTTGCCG AAGCCAATGC CGAAGCCATC 751CGTCAAATTG CCGCCGCCCT TCAAACCCAA GGCGGTGCGG ATGCGGTCAA 801 TCTGAAGATTGCGGAACAAT ACGTCGCCGC GTTCAACAAT CTTGCCAAAG 851 AAAGCAATAC GCTGATTATGCCCGCCAATG TTGCCGACAT CGGCAGCCTG 901 ATTTCTGCCG GTATGAAAAT TATCGACAGCAGCAAAACCG CCAAATAAThis corresponds to the amino acid sequence <SEQ ID 1452; ORF 519.a>:

a519.pep 1 MEFFIILLAA VVVFGFKSFV VIPQQEVHVV ERLGRFHRAL TAGLNILIPF 51IDRVAYRHSL KEIPLDVPSQ VCITRDNTQL TVDGIIYFQV TDPKLASYGS 101 SNYIMAITQLAQTTLRSVIG RMELDKTFEE RDEINSTVVS ALDEAAGAWG 151 VKVLRYEIKD LVPPQEILRSMQAQITAERE KRARIAESEG RKIEQINLAS 201 GQREAEIQQS EGEAQAAVNA SNAEKIARINRAKGEAESLR LVAEANAEAI 251 RQIAAALQTQ GGADAVNLKI AEQYVAAFNN LAKESNTLIMPANVADIGSL 301 ISAGMKIIDS SKTAK* m519/a519 99.5% identity in 199 aaoverlap                                       10        20        30m519.pep                               SVIGRMELDKTFEERDEINSTVVAALDEAA                              |||||||||||||||||||||||:|||||| a519YFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIGRMELDKTFEERDEINSTVVSALDEAA  90       100       110       120       130       140        40        50        60        70        80        90 m519.pepGAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a519GAWGVKVLRYEIKDLVPPQEILRSMQAQITAEREKRARIAESEGRKIEQINLASGQREAE 150       160       170       180       190       200       100       110       120       130       140       150 m519.pepIQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a519IQQSEGEAQAAVNASNAEKIARINRAKGEAESLRLVAEANAEAIRQIAAALQTQGGADAV 210       220       230       240       250       260       160       170       180       190       200 m519.pepNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSLISAGMKIIDSSKTAKX|||||||||||||||||||||||||||||||||||||||||||||||||| a519NLKIAEQYVAAFNNLAKESNTLIMPANVADIGSLISAGMKIIDSSKTAKX 270       280       290       300       310The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1453>:

g519-1.seq 1 ATGGAATTTT TCATTATCTT GTTGGCAGCC GTCGCCGTTT TCGGCTTCAA 51ATCCTTTGTC GTCATCCCCC AGCAGGAAGT CCACGTTGTC GAAAGGCTCG 101 GGCGTTTCCATCGCGCCCTG ACGGCCGGTT TGAATATTTT GATTCCCTTT 151 ATCGACCGCG TCGCCTACCGCCATTCGCTG AAAGAAATCC CTTTAGACGT 201 ACCCAGCCAG GTCTGCATCA CGCGCGATAATACGCAATTG ACTGTTGACG 251 GCATCATCTA TTTCCAAGTA ACCGATCCCA AACTCGCCTCATACGGTTCG 301 AGCAACTACA TTATGGCAAT TACCCAGCTT GCCCAAACGA CGCTGCGTTC351 CGTTATCGGG CGTATGGAGT TGGACAAAAC GTTTGAAGAA CGCGACGAAA 401TCAACAGTAC CGTCGTCTCC GCCCTCGATG AAGCCGCCGG GGCTTGGGGT 451 GTGAAAGTCCTCCGTTACGA AATCAAGGAT TTGGTTCCGC CGCAAGAAAT 501 CCTTCGCGCA ATGCAGGCACAAATTACCGC CGAACGCGAA AAACGCGCCC 551 GTATTGCCGA ATCCGAAGGC CGTAAAATCGAACAAATCAA CCTTGCCAGT 601 GGTCAGCGTG AAGCCGAAAT CCAACAATCC GAAGGCGAGGCTCAGGCTGC 651 GGTCAATGCG TCCAATGCCG AGAAAATCGC CCGCATCAAC CGCGCCAAAG701 GCGAAGCGGA ATCCCTGCGC CTTGTTGCCG AAGCCAATGC CGAAGCCATC 751CGTCAAATTG CCGCCGCCCT TCAAACCCAA GGCGGGGCGG ATGCGGTCAA 801 TCTGAAGATTGCGGAACAAT ACGTAGCCGC GTTCAACAAT CTTGCCAAAG 851 AAAGCAATAC GCTGATTATGCCCGCCAATG TTGCCGACAT CGGCAGCCTG 901 ATTTCTGCCG GCATGAAAAT TATCGACAGCAGCAAAACCG CCAAATAAThis corresponds to the amino acid sequence <SEQ ID 1454; ORF 519-1.ng>:

g519-1.pep 1 MEFFIILLAA VAVFGFKSFV VIPQQEVHVV ERLGRFHRAL TAGLNILIPF 51IDRVAYRHSL KEIPLDVPSQ VCITRDNTQL TVDGIIYFQV TDPKLASYGS 101 SNYIMAITQLAQTTLRSVIG RMELDKTFEE RDEINSTVVS ALDEAAGAWG 151 VKVLRYEIKD LVPPQEILRAMQAQITAERE KRARIAESEG RKIEQINLAS 201 GQREAEIQQS EGEAQAAVNA SNAEKIARINRAKGEAESLR LVAEANAEAI 251 RQIAAALQTQ GGADAVNLKI AEQYVAAFNN LAKESNTLIMPANVADIGSL 301 ISAGMKIIDS SKTAK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1455>:

m519-1.seq 1 ATGGAATTTT TCATTATCTT GTTGGTAGCC GTCGCCGTTT TCGGTTTCAA 51ATCCTTTGTT GTCATCCCAC AACAGGAAGT CCACGTTGTC GAAAGGCTGG 101 GGCGTTTCCATCGCGCCCTG ACGGcCGGTT TGAATATTTT GATTCCCTTT 151 ATCGACCGCG TCGCCTACCGCCATTCGCTG AAAGAAATCC CTTTAGACGT 201 ACCCAGCCAG GTCTGCATCA CGCGCGACAATACGCAGCTG ACTGTTGACG 251 GCATCATCTA TTTCCAAGTA ACCGACCCCA AACTCGCCTCATACGGTTCG 301 AGCAACTACA TTATGGCGAT TACCCAGCTT GCCCAAACGA CGCTGCGTTC351 CGTTATCGGG CGTATGGAGT TGGACAAAAC GTTTGAAGAA CGCGACGAAA 401TCAACAGTAC TGTTGTTGCG GCTTTGGACG AGGCGGCCGG GGCTTGGGGT 451 GTGAAGGTTTTGCGTTATGA GATTAAAGAC TTGGTTCCGC CGCAAGAAAT 501 CCTTCGCTCA ATGCAGGCGCAAATTACTGC CGAACGCGAA AAACGCGCCC 551 GTATCGCCGA ATCCGAAGGT CGTAAAATCGAACAAATCAA CCTTGCCAGT 601 GGTCAGCGCG AAGCCGAAAT CCAACAATCC GAAGGCGAGGCTCAGGCTGC 651 GGTCAATGCG TCAAATGCCG AGAAAATCGC CCGCATCAAC CGCGCCAAAG701 GTGAAGCGGA ATCCTTGCGC CTTGTTGCCG AAGCCAATGC CGAAGCCATC 751CGTCAAATTG CCGCCGCCCT TCAAACCCAA GGCGGTGCGG ATGCGGTCAA 801 TCTGAAGATTGCGGAACAAT ACGTCGCTGC GTTCAACAAT CTTGCCAAAG 851 AAAGCAATAC GCTGATTATGCCCGCCAATG TTGCCGACAT CGGCAGCCTG 901 ATTTCTGCCG GTATGAAAAT TATCGACAGCAGCAAAACCG CCAAATAAThis corresponds to the amino acid sequence <SEQ ID 1456; ORF 519-1>:

m519-1. 1 MEFFIILLVA VAVFGFKSFV VIPQQEVHVV ERLGRFHRAL TAGLNILIPF 51IDRVAYRHSL KEIPLDVPSQ VCITRDNTQL TVDGIIYFQV TDPKLASYGS 101 SNYIMAITQLAQTTLRSVIG RMELDKTFEE RDEINSTVVA ALDEAAGAWG 151 VKVLRYEIKD LVPPQEILRSMQAQITAERE KRARIAESEG RKIEQINLAS 201 GQREAEIQQS EGEAQAAVNA SNAEKIARINRAKGEAESLR LVAEANAEAI 251 RQIAAALQTQ GGADAVNLKI AEQYVAAFNN LAKESNTLIMPANVADIGSL 301 ISAGMKIIDS SKTAK* m519-1/g519-1 99.0% identity in 315 aaoverlap         10        20        30        40        50        60g519-1.pep MEFFIILLAAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSL||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSL        10        20        30        40        50        60        70        80        90       100       110       120 g519-1.pepKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1KEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIG        70        80        90       100       110       120       130       140       150       160       170       180 g519-1.pepRMELDKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRAMQAQITAERE|||||||||||||||||||:|||||||||||||||||||||||||||||:|||||||||| m519-1RMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAERE       130       140       150       160       170       180       190       200       210       220       230       240 g519-1.pepKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1KRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLR       190       200       210       220       230       240       250       260       270       280       290       300 g519-1.pepLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1LVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL       250       260       270       280       290       300        310g519-1.pep ISAGMKIIDSSKTAKX |||||||||||||||| m519-1 ISAGMKIIDSSKTAKX       310The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1457>:

a519-1.seq 1 ATGGAATTTT TCATTATCTT GCTGGCAGCC GTCGTTGTTT TCGGCTTCAA 51ATCCTTTGTT GTCATCCCAC AGCAGGAAGT CCACGTTGTC GAAAGGCTCG 101 GGCGTTTCCATCGCGCCCTG ACGGCCGGTT TGAATATTTT GATTCCCTTT 151 ATCGACCGCG TCGCCTACCGCCATTCGCTG AAAGAAATCC CTTTAGACGT 201 ACCCAGCCAG GTCTGCATCA CGCGCGACAATACGCAGCTG ACTGTTGACG 251 GTATCATCTA TTTCCAAGTA ACCGACCCCA AACTCGCCTCATACGGTTCG 301 AGCAACTACA TTATGGCGAT TACCCAGCTT GCCCAAACGA CGCTGCGTTC351 CGTTATCGGG CGTATGGAAT TGGACAAAAC GTTTGAAGAA CGCGACGAAA 401TCAACAGCAC CGTCGTCTCC GCCCTCGATG AAGCCGCCGG AGCTTGGGGT 451 GTGAAGGTTTTGCGTTATGA GATTAAAGAC TTGGTTCCGC CGCAAGAAAT 501 CCTTCGCTCA ATGCAGGCGCAAATTACTGC TGAACGCGAA AAACGCGCCC 551 GTATCGCCGA ATCCGAAGGT CGTAAAATCGAACAAATCAA CCTTGCCAGT 601 GGTCAGCGCG AAGCCGAAAT CCAACAATCC GAAGGCGAGGCTCAGGCTGC 651 GGTCAATGCG TCAAATGCCG AGAAAATCGC CCGCATCAAC CGCGCCAAAG701 GTGAAGCGGA ATCCTTGCGC CTTGTTGCCG AAGCCAATGC CGAAGCCATC 751CGTCAAATTG CCGCCGCCCT TCAAACCCAA GGCGGTGCGG ATGCGGTCAA 801 TCTGAAGATTGCGGAACAAT ACGTCGCCGC GTTCAACAAT CTTGCCAAAG 851 AAAGCAATAC GCTGATTATGCCCGCCAATG TTGCCGACAT CGGCAGCCTG 901 ATTTCTGCCG GTATGAAAAT TATCGACAGCAGCAAAACCG CCAAATAAThis corresponds to the amino acid sequence <SEQ ID 1458; ORF 519-1.a>:

a519-1.pep. 1 MEFFIILLAA VVVFGFKSFV VIPQQEVHVV ERLGRFHRAL TAGLNILIPF 51IDRVAYRHSL KEIPLDVPSQ VCITRDNTQL TVDGIIYFQV TDPKLASYGS 101 SNYIMAITQLAQTTLRSVIG RMELDKTFEE RDEINSTVVS ALDEAAGAWG 151 VKVLRYEIKD LVPPQEILRSMQAQITAERE KRARIAESEG RKIEQINLAS 201 GQREAEIQQS EGEAQAAVNA SNAEKIARINRAKGEAESLR LVAEANAEAI 251 RQIAAALQTQ GGADAVNLKI AEQYVAAFNN LAKESNTLIMPANVADIGSL 301 ISAGMKIIDS SKTAK* m519-1/a519-1 99.0% identity in 315 aaoverlap         10        20        30        40        50        60a519-1.pep MEFFIILLAAVVVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSL||||||||:||:|||||||||||||||||||||||||||||||||||||||||||||||| m519-1MEFFIILLVAVAVFGFKSFVVIPQQEVHVVERLGRFHRALTAGLNILIPFIDRVAYRHSL        10        20        30        40        50        60        70        80        90       100       110       120 a519-1.pepKEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1KEIPLDVPSQVCITRDNTQLTVDGIIYFQVTDPKLASYGSSNYIMAITQLAQTTLRSVIG        70        80        90       100       110       120       130       140       150       160       170       180 a519-1.pepRMELDKTFEERDEINSTVVSALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAERE|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||| m519-1RMELDKTFEERDEINSTVVAALDEAAGAWGVKVLRYEIKDLVPPQEILRSMQAQITAERE       130       140       150       160       170       180       190       200       210       220       230       240 a519-1.pepKRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1KRARIAESEGRKIEQINLASGQREAEIQQSEGEAQAAVNASNAEKIARINRAKGEAESLR       190       200       210       220       230       240       250       260       270       280       290       300 a519-1.pepLVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m519-1LVAEANAEAIRQIAAALQTQGGADAVNLKIAEQYVAAFNNLAKESNTLIMPANVADIGSL       250       260       270       280       290       300        310a519-1.pep ISAGMKIIDSSKTAKX |||||||||||||||| m519-1 ISAGMKIIDSSKTAKX       310

Expression of ORF 519

The primer described in Table 1 for ORF 519 was used to locate and cloneORF 519. ORF 519 was cloned in pET and pGex vectors and expressed in E.coli as above described. The products of protein expression andpurification were analyzed by SDS-PAGE. FIG. 4A shows the results ofaffinity purification, and FIG. 4B shows the expression in E. coli.Purified Nis-fusion protein was used to immunize mice whose sera wereused for ELISA (positive result), FACS analysis (FIG. 4C), western blot(FIG. 1E), and a bactericidal assay (FIG. 4D). These experiments confirmthat 519 is a surface-exposed protein and that it is a useful immunogen.The hydrophilicity plots, antigenic index, and amphipatic regions of ORF519 are provided in FIG. 8. The AMPHI program is used to predictputative T-cell epitopes (Gao et al 1989, J. Immunol 143:3007; Robertset al. 1996, AIDS Res Human Retroviruses 12:593; Quakyi et al. 1992,Scand J Immunol Suppl 11:9). The nucleic acid sequence of ORF 519 andthe amino acid sequence encoded thereby as provided herein.

The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1459>:

g520.seq 1 atgcctgcgc ttctttcaat acgtcgggca aacgcgctgc ctttttcgcg 51catttcggaa aggatgaagt tgctggtgcc gttaataatg ccggcgatgg 101 atttaatcctgtttgccgcc aaaccttcgc gcacggcttt gatgattggg 151 ataccgcccg ctactgccgcttcaaattgg acgatgacgt tttgtttttc 201 cgccagcggg aagatttcgt tgccgtattcggcgagcagt tttttgttgg 251 cggtaacgat gtgtttgccg ttttcaatgg ctttcaacaccgcttctttg 301 gcaatgcccg tgccgccgaa caattcgacc aagacatcga cgtctttacg351 cgcgaacagt tcgaacggat cttttgacaa gggcgggcga cgggccgatt 401ttggcgggct ttttcttcgc ttaagtcgca catggcagaa atacggattt 451 cgcgccccaagcggcgggaa atttcctctg cgttgtcccg caacacggca 501 gccgcaccgc cgccgaccgtacctaagcct aaaagaccga tgtttactgg 551 cttcattgtg tctccttgta agccgactgaaatgtaaata ttgaThis corresponds to the amino acid sequence <SEQ ID 1460; ORF 520.ng>:

g520.pep 1 MPALLSIRRA NALPFSRISE RMKLLVPLIM PAMDLILFAA KPSRTALMIG 51IPPATAASNW TMTFCFSASG KISLPYSASS FLLAVTMCLP FSMAFNTASL 101 AMPVPPNNSTKTSTSLRANS SNGSFDKGGR RADFGGLFLR LSRTWQKYGF 151 RAPSGGKFPL RCPATRQPHRRRPYLSLKDR CLLASLCLLV SRLKCKY*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1461>:

m520.seq 1 ATGCCTGCGC TTCTTTCAGT ACATCG.GCA AACGCGCTGC CTTTTTCGCG 51CATTTCGGrk AGGATGAAGT TGCTGGTGCC GTTAATAATG CCGGCGATGG 101 ATTTAATCCTGTTTGCCGCC AAACCTTCGC GCAGGGCTTT GATGATTGGG 151 ATACCGCCCG CTACTGCCGCTTCAAATTGG ACGATGACGT TTTGTTTTTC 201 CGCCAGCGGG AAGATTTCGT TGCCGTATTCGGCGAGCAGT TTTTTGTTGG 251 CGGTAACGAT GTGTTTGCCG TTTTCAATGG CTTTCAACACCGCATCTTTG 301 GCAATGCCGG TACCGCCGaA CAATTCGACG ACGACATCGA CGTCTTCACG351 TGCGACCAGT TCGAACGGAT CTTTGACAAA GGCTGc.CGG ACGGGCAGGT 401TTGTCGGGCT TTTTCTTCAC TCAAATCGCA CACGGCAGAA ATACGGATTT 451 CGCGCCCCAAGCGACGGGAA ATTTCCTCCG CGTTGTCsCG CAACACGGCA 501 GCCGTACCGC CGCCGACCGTACCCAAACCT AAAAGACCGA TGTTTACTGG 551 CTTCATTGTG TCTCCTTGTA AGCCGACTGAAATGTAAATA TTGAThis corresponds to the amino acid sequence <SEQ ID 1462; ORF 520>:

m520.pep 1 MPALLSVHXA NALPFSRISX RMKLLVPLIM PAMDLILFAA KPSRRALMIG 51IPPATAASNW TMTFCFSASG KISLPYSASS FLLAVTMCLP FSMAFNTASL 101 AMPVPPNNSTTTSTSSRATS SNGSLTKAXR TGRFVGLFLH SNRTRQKYGF 151 RAPSDGKFPP RCXATRQPYRRRPYPNLKDR CLLASLCLLV SRLKCKY*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 520 shows 87.3% identity over a 197 aa overlap with a predicted ORF(ORF 520.ng) from N. gonorrhoeae:

m520/g520         10        20        30        40        50        60m520.pep MPALLSVHRANALPFSRISXRMKLLVPLIMPAMDLILFAAKPSRRALMIGIPPATAASNW||||||::||||||||||| |||||||||||||||||||||||| ||||||||||||||| g520MPALLSIRRANALPFSRISERMKLLVPLIMPAMDLILFAAKPSRTALMIGIPPATAASNW        10        20        30        40        50        60        70        80        90       100       110       120 m520.pepTMTFCFSASGKISLPYSASSFLLAVTMCLPFSMAFNTASLAMPVPPNNSTTTSTSSRATS|||||||||||||||||||||||||||||||||||||||||||||||||| |||| ||:| g520TMTFCFSASGKISLPYSASSFLLAVTMCLPFSMAFNTASLAMPVPPNNSTKTSTSLRANS        70        80        90       100       110       120       130       140       150       160       170       180 m520.pepSNGSLTKAARTGRFVGLFLHSNRTRQKYGFRAPSDGKFPPRCXATRQPYRRRPYPNLKDR ||||:|::| : | ||||: :|| ||||||||| |||| || |||||:||||| :|||| g520SNGSFDKGGRRADFGGLFLRLSRTWQKYGFRAPSGGKFPLRCPATRQPHRRRPYLSLKDR       130       140       150       160       170       180        190m520.pep CLLASLCLLVSRLKCKY ||||||||||||||||| g520 CLLASLCLLVSRLKCKY       190The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1463>:

a520.seq 1 ATGCCTGCGC TTCTTTCAGT ACATCGG.CA AACGCGCTGC CTTTTTCGCG 51CATTTCGGAG AGGATGAAGT TGCTGGTGCC GTTAATAATG CCGGCGATGG 101 ATTTAATCCTGTTTGCCGCC AAACCTTCGC GCAGGGCTTT GATGATTGGG 151 ATACCGCCCG CTACTGCCGCTTCAAATTGG ACGATGACGT TTTGTTTTTC 201 CGCCAGCGGG AAGATTTCGT TGCCGTATTCGGCGAGCAGT TTTTTGTTGG 251 CGGTAACGAT GTGTTTGCCG TTTTCAATGG CTTTCAACACCGCATCTTTG 301 GCAATGCCGG TACCGCCGAA CAATTCGACG ACGACATCGA CGTCTTCACG351 TGCGACCAGT TCGAACGGAT CTTTGACAAA GGCTG..CGG ACGGGCAGGT 401TTGTCGGGCT TTTTCTTCAC TCAAATCGCA CACGGCAGAA ATACGGATTT 451 CGCGCCCCAAGCGACGGGAA ATTTCCTCCG CGTTGTCCCG CAACACGGCA 501 GCCGTACCGC CGCCGACCGTACCCAAACCT AAAAGACCGA TGTTTACTGG 551 CTTCATTGTG TCTCCTTGTA AGCCGACTGAAATGTAAATA TTGAThis corresponds to the amino acid sequence <SEQ ID 1464; ORF 520.a>:

a520.pep 1 MPALLSVHRX NALPFSRISE RMKLLVPLIM PAMDLILFAA KPSRRALMIG 51IPPATAASNW TMTFCFSASG KISLPYSASS FLLAVTMCLP FSMAFNTASL 101 AMPVPPNNSTTTSTSSRATS SNGSLTKAXR TGRFVGLFLH SNRTRQKYGF 151 RAPSDGKFPP RCPATRQPYRRRPYPNLKDR CLLASLCLLV SRLKCKY* m520/a520 98.0% identity in 197 aaoverlap         10        20        30        40        50        60m520.pep MPALLSVHXANALPFSRISXRMKLLVPLIMPAMDLILFAAKPSRRALMIGIPPATAASNW||||||||  ||||||||| |||||||||||||||||||||||||||||||||||||||| a520MPALLSVHRXNALPFSRISERMKLLVPLIMPAMDLILFAAKPSRRALMIGIPPATAASNW        10        20        30        40        50        60        70        80        90       100       110       120 m520.pepTMTFCFSASGKISLPYSASSFLLAVTMCLPFSMAFNTASLAMPVPPNNSTTTSTSSRATS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a520TMTFCFSASGKISLPYSASSFLLAVTMCLPFSMAFNTASLAMPVPPNNSTTTSTSSRATS        70        80        90       100       110       120       130       140       150       160       170       180 m520.pepSNGSLTKAXRTGRFVGLFLHSNRTRQKYGFRAPSDGKFPPRCXATRQPYRRRPYPNLKDR|||||||||||||||||||||||||||||||||||||||||| ||||||||||||||||| a520SNGSLTKAXRTGRFVGLFLHSNRTRQKYGFRAPSDGKFPPRCPATRQPYRRRPYPNLKDR       130       140       150       160       170       180        190m520.pep CLLASLCLLVSRLKCKYX |||||||||||||||||| a520 CLLASLCLLVSRLKCKYX       190The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1465>:

g520-1.seq 1 ATGAAGTTGC TGGTGCCGTT AATAATGCCG GCGATGGATT TAATCCTGTT 51TGCCGCCAAA CCTTCGCGCA GGGCTTTGAT GATTGGGATA CCGCCCGCTA 101 CTGCCGCTTCAAATTGGACG ATGACGTTTT GTTTTTCCGC CAGCGGGAAG 151 ATTTCGTTGC CGTATTCGGCGAGCAGTTTT TTGTTGGCGG TAACGATGTG 201 TTTGCCGTTT TCAATGGCTT TCAACACCGCTTCTTTGGCA ATGCCCGTGC 251 CGccgAACAA TTCGACGACG ACATCGACGT CTTTACGCGCGACCAGTtCG 301 AACGGATCTT TGACAAAGGC GGCGGACGGG CAGATTTGGC GGGCTTTTTC351 TTCGCTTAAG TCGCACATGG CAGAAATACG GATTTCGCGC CCCAAGCGGC 401GGGAAATTTC CTCTGCGTTG TCCCGCAACA CGGCAGCCGC ACCGCCGCCG 451 ACCgTACCTAAGCCTAAAAG ACCGATGTTT ACTGGCTTCA TTGTGTCTCC 501 TTGTAAGCCG ACTGAAATGT AAThis corresponds to the amino acid sequence <SEQ ID 1466; ORF 520-1.ng>:

g520-1.pep 1 MKLLVPLIMP AMDLILFAAK PSRRALMIGI PPATAASNWT MTFCFSASGK 51ISLPYSASSF LLAVTMCLPF SMAFNTASLA MPVPPNNSTT TSTSLRATSS 101 NGSLTKAADGQIWRAFSSLK SHMAEIRISR PKRREISSAL SRNTAAAPPP 151 TVPKPKRPMF TGFIVSPCKPTEM*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1467>:

m520-1.seq 1 ATGAAGTTGC TGGTGCCGTT AATAATGCCG GCGATGGATT TAATCCTGTT 51TGCCGCCAAA CCTTCGCGCA GGGCTTTGAT GATTGGGATA CCGCCCGCTA 101 CTGCCGCTTCAAATTGGACG ATGACGTTTT GTTTTTCCGC CAGCGGGAAG 151 ATTTCGTTGC CGTATTCGGCGAGCAGTTTT TTGTTGGCGG TAACGATGTG 201 TTTGCCGTTT TCAATGGCTT TCAACACCGCATCTTTGGCA ATGCCGGTAC 251 CGCCGAACAA TTCGACGACG ACATCGACGT CTTCACGTGCGACCAGTTCG 301 AACGGATCTT TGACAAAGGC TGCGGACGGG CAGGTTTGTC GGGCTTTTTC351 TTCACTCAAA TCGCACACGG CAGAAATACG GATTTCGCGC CCCAAGCGAC 401GGGAAATTTC CTCCGCGTTG TCCCGCAACA CGGCAGCCGT ACCGCCGCCG 451 ACCGTACCCAAACCTAAAAG ACCGATGTTT ACTGGCTTCA TTGTGTCTCC 501 TTGTAAGCCG ACTGAAATGT AAThis corresponds to the amino acid sequence <SEQ ID 1468; ORF 520-1>:

m520-1.pep 1 MKLLVPLIMP AMDLILFAAK PSRRALMIGI PPATAASNWT MTFCFSASGK 51ISLPYSASSF LLAVTMCLPF SMAFNTASLA MPVPPNNSTT TSTSSRATSS 101 NGSLTKAADGQVCRAFSSLK SHTAEIRISR PKRREISSAL SRNTAAVPPP 151 TVPKPKRPMF TGFIVSPCKPTEM* g520-1/m520-1 97.1% identity in 173 aa overlap        10        20        30        40        50        60 g520-1.pepMKLLVPLIMPAMDLILFAAKPSRRALMIGIPPATAASNWTMTFCFSASGKISLPYSASSF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m520-1MKLLVPLIMPAMDLILFAAKPSRRALMIGIPPATAASNWTMTFCFSASGKISLPYSASSF        10        20        30        40        50        60        70        80        90       100       110       120 g520-1.pepLLAVTMCLPFSMAFNTASLAMPVPPNNSTTTSTSLRATSSNGSLTKAADGQIWRAFSSLK|||||||||||||||||||||||||||||||||| ||||||||||||||||: ||||||| m520-1LLAVTMCLPFSMAFNTASLAMPVPPNNSTTTSTSSRATSSNGSLTKAADGQVCRAFSSLK        70        80        90       100       110       120       130       140       150       160       170 g520-1.pepSHMAEIRISRPKRREISSALSRNTAAAPPPTVPKPKRPMFTGFIVSPCKPTEMX|| |||||||||||||||||||||||:||||||||||||||||||||||||||| m520-1SHTAEIRISRPKRREISSALSRNTAAVPPPTVPKPKRPMFTGFIVSPCKPTEMX       130       140       150       160       170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1469>:

a520-1.seq 1 ATGAAGTTGC TGGTGCCGTT AATAATGCCG GCGATGGATT TAATCCTGTT 51TGCCGCCAAA CCTTCGCGCA GGGCTTTGAT GATTGGGATA CCGCCCGCTA 101 CTGCCGCTTCAAATTGGACG ATGACGTTTT GTTTTTCCGC CAGCGGGAAG 151 ATTTCGTTGC CGTATTCGGCGAGCAGTTTT TTGTTGGCGG TAACGATGTG 201 TTTGCCGTTT TCAATGGCTT TCAACACCGCATCTTTGGCA ATGCCGGTAC 251 CGCCGAACAA TTCGACGACG ACATCGACGT CTTCACGTGCGACCAGTTCG 301 AACGGATCTT TGACAAAGGC TGCGGACGGG CAGGTTTGTC GGGCTTTTTC351 TTCACTCAAA TCGCACACGG CAGAAATACG GATTTCGCGC CCCAAGCGAC 401GGGAAATTTC CTCCGCGTTG TCCCGCAACA CGGCAGCCGT ACCGCCGCCG 451 ACCGTACCCAAACCTAAAAG ACCGATGTTT ACTGGCTTCA TTGTGTCTCC 501 TTGTAAGCCG ACTGAAATGT AAThis corresponds to the amino acid sequence <SEQ ID 1470; ORF 520-1.a>:

a520-1.pep 1 MKLLVPLIMP AMDLILFAAK PSRRALMIGI PPATAASNWT MTFCFSASGK 51ISLPYSASSF LLAVTMCLPF SMAFNTASLA MPVPPNNSTT TSTSSRATSS 101 NGSLTKAADGQVCRAFSSLK SHTAEIRISR PKRREISSAL SRNTAAVPPP 151 TVPKPKRPMF TGFIVSPCKPTEM* m520-1/a520-1 100.0% identity in 173 aa overlap        10        20        30        40        50        60 a520-1.pepMKLLVPLIMPAMDLILFAAKPSRRALMIGIPPATAASNWTMTFCFSASGKISLPYSASSF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m520-1MKLLVPLIMPAMDLILFAAKPSRRALMIGIPPATAASNWTMTFCFSASGKISLPYSASSF        10        20        30        40        50        60        70        80        90       100       110       120 a520-1.pepLLAVTMCLPFSMAFNTASLAMPVPPNNSTTTSTSSRATSSNGSLTKAADGQVCRAFSSLK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m520-1LLAVTMCLPFSMAFNTASLAMPVPPNNSTTTSTSSRATSSNGSLTKAADGQVCRAFSSLK        70        80        90       100       110       120       130       140       150       160       170 a520-1.pepSHTAEIRISRPKRREISSALSRNTAAVPPPTVPKPKRPMFTGFIVSPCKPTEMX|||||||||||||||||||||||||||||||||||||||||||||||||||||| m520-1SHTAEIRISRPKRREISSALSRNTAAVPPPTVPKPKRPMFTGFIVSPCKPTEMX       130       140       150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1471>:

g521.seq 1 ATGAAATCAA AACTCCCCTT AATCCTAATC AACCTTTCCC TGATTTCAAG 51CCCATTGGGT GCGAATGCGG CCAAAATCTA TACCTGCACA ATCAACGGAG 101 AAACCGTTTACACCACCAAG CCGTCTAAAA GCTGCCACTC AACCGATTTG 151 CCCCCAATCG GCAACTACAGCAGCGAACGC TATATCCTGC CCCAAACTCC 201 CGAACCGGCA CCATCACCGT CAAACGGCGGACAGGCTGTC AAATATAAAG 251 CCCCGGTCAA AACAGTATCC AAGCCGGCAA AATCCAATACGCCGCCTCAA 301 CAAGCACCTG TAAATAACAG CAGACGCTCC ATTCTcgaag caGaattaag351 cAatgaacgc aaagccctGa ctGaAGCCCA AAAAATGTTA TCACAagcac 401gtCtGGCAAA AGGCGgcaAC AtcaaCCatc aaaAaatcaa cgcattgtaa 451 AGCAATGTTttggacAGACA GCAAAATaTC Caagcactgc aaaGAgAATt 501 GGGACGTATG TAAThis corresponds to the amino acid sequence <SEQ ID 1472; ORF 521.ng>:

g521n.pep 1 MKSKLPLILI NLSLISSPLG ANAAKIYTCT INGETVYTTK PSKSCHSTDL 51PPIGNYSSER YILPQTPEPA PSPSNGGQAV KYKAPVKTVS KPAKSNTPPQ 101 QAPVNNSRRSILEAELSNER KALTEAQKML SQARLAKGGN INHQKINAL* 151 SNVLDRQQNI QALQRELGRM *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1473>:

m521.seq 1 ATGAAATCAA AACTCCTCTT AATCCTAATC AACTTTTCCC TGATTTCAAG 51CCCATTGGGT GCGAATGCGG CCAAAATCTA sACCTGCACA ATCAACGGAG 101 AAACCGTTTACACCAsCAAG CCGTCCAAAA GCTGCCACTC AACCGATTTG 151 CCCCCAATCG GCAACTACAGCAGCGAACGC TATATCCCGC CCCAAACGCC 201 CGAACCGGTA TCATCACCGT CAAACGGCGGACwGGTTGTC AAATATAAAG 251 CCCCGGTCAA AACAGTATCC AAGCCGGCAA AATCCArTACGCCGCCGCCG 301 CAACAAGCAC CCTCAAACAA CAGCAGACGC TCCATTCTCG AAACAGAATT351 GAGCAACGAA CGCAAAGCAT TGGTTGAAGC CCAAAAAATG TTATCACAAG 401CACGTCTGGC AAAGGGCGGC AACATCAACC ATCAAGAAAT AAATGCATTA 451 CAAAGCAATGTATTGGACAG GCAGCAAAAT ATTCAAGCCC TGCAAAGGGA 501 ACTGGGGCGT ATGTAAThis corresponds to the amino acid sequence <SEQ ID 1474; ORF 521>:

m521.pep 1 MKSKLLLILI NFSLISSPLG ANAAKIXTCT INGETVYTXK PSKSCHSTDL 51PPIGNYSSER YIPPQTPEPV SSPSNGGXVV KYKAPVKTVS KPAKSXTPPP 101 QQAPSNNSRRSILETELSNE RKALVEAQKM LSQARLAKGG NINHQEINAL 151 QSNVLDRQQN IQALQRELGR M*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 521 shows 90.6% identity over a 171 aa overlap with a predicted ORF(ORF 521.ng) from N. gonorrhoeae:

m521/g521           10        20        30        40        50        60m521.pep   MKSKLLLILINFSLISSPLGANAAKIXTCTINGETVYTXKPSKSCHSTDLPPIGNYSSER  ||||| |||||:|||||||||||||| |||||||||||:||||||||||||||||||||| g521  MKSKLPLILINLSLISSPLGANAAKIYTCTINGETVYTTKPSKSCHSTDLPPIGNYSSER          10        20        30        40        50        60          70        80        90       100       110       120 m521.pep  YIPPQTPEPVSSPSNGGXVVKYKAPVKTVSKPAKSXTPPPQQAPSNNSRRSILETELSNE  || ||||||: |||||| :|||||||||||||||| ||| |||| |||||||||:||||| g521  YILPQTPEPAPSPSNGGQAVKYKAPVKTVSKPAKSNTPP-QQAPVNNSRRSILEAELSNE          70        80        90        100       110         130       140       150       160       170 m521.pep  RKALVEAQKMLSQARLAKGGNINHQEINALQSNVLDRQQNIQALQRELGRMX  ||||:||||||||||||||||||||:|||| ||||||||||||||||||||| g521  RKALTEAQKMLSQARLAKGGNINHQKINALXSNVLDRQQNIQALQRELGRMX120       130       140       150       160       170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1475>:

a521.seq 1 ATGAAATCAA AACTCCCCTT AATCCTAATC AACTTTTCCC TGATTTCAAG 51CCCATTGGGT GCGAATGCGG CCAAAATCTA CACCTGCACA ATCAACGGAG 101 AAACCGTTTACACCACCAAG CCGTCCAAAA GCTGCCTCTC AACCGATTTG 151 CCCCCAATCG GCAACTACAGCAGCGAACGC TATATCCCGC CCCAAACATC 201 CGAACCGACA CCATCACCGT CAAACGGCGGACAGGCTGTC AAATATAAAG 251 CCCCGGTCAA AACAGTATCC AAGCCGGCAA AATCCAATACGCCGCCGCCG 301 CAACAAGCAC CCTCAAACAA CAGCAGACGC TCCATTCTCG AAACAGAATT351 GAGCAACGAA CGCAAAGCAT TGGTTGAAGC CCAAAAAATG TTATCACAAG 401CACGTCTGGC AAAAGGCGGC AACATCAACC ATCAAGAAAT CAACGCATTG 451 CAAAGCAATGTATTGGACAG GCAGCAAAAT ATCCAAGCAC TGCAAAGAGA 501 ATTGGGACGT ATGTAAThis corresponds to the amino acid sequence <SEQ ID 1476; ORF 521.a>:

a521.pep 1 MKSKLPLILI NFSLISSPLG ANAAKIYTCT INGETVYTTK PSKSCLSTDL 51PPIGNYSSER YIPPQTSEPT PSPSNGGQAV KYKAPVKTVS KPAKSNTPPP 101 QQAPSNNSRRSILETELSNE RKALVEAQKM LSQARLAKGG NINHQEINAL 151 QSVLDRQQN IQALQRELGR M*m521/a521 94.2% identity in 171 aa overlap        10        20        30        40        50        60 m521.pepMKSKLLLILINFSLISSPLGANAAKIXTCTINGETVYTXKPSKSCHSTDLPPIGNYSSER||||| |||||||||||||||||||| |||||||||||:|||||| |||||||||||||| a521MKSKLPLILINFSLISSPLGANAAKIYTCTINGETVYTTKPSKSCLSTDLPPIGNYSSER        10        20        30        40        50        60        70        80        90       100       110       120 m521.pepYIPPQTPEPVSSPSNGGXVVKYKAPVKTVSKPAKSXTPPPQQAPSNNSRRSILETELSNE |||||| ||:|||||| :|||||||||||||||| |||||||||||||||||||||||| a521YIPPQTSEPTPSPSNGGQAVKYKAPVKTVSKPAKSNTPPPQQAPSNNSRRSILETELSNE        70        80        90       100       110       120       130       140       150       160       170 m521.pepRKALVEAQKMLSQARLAKGGNINHQEINALQSNVLDRQQNIQALQRELGRMX|||||||||||||||||||||||||||||||||||||||||||||||||||| a521RKALVEAQKMLSQARLAKGGNINHQEINALQSNVLDRQQNIQALQRELGRMX       130       140       150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1477>:

g522.seq 1 atgactgagc cgaaacacga aacgccgacg gaagagcagg ttgccgcgcg 51caaaaaagca aaagccaaaa tccgcaccat ccgcatttgg gcgtgggtca 101 ttttggcgttgctcgcttca accgccctgc tctcccaatg cgcgatgtcc 151 aaaccgcagg caaaacagaaaattgtcgag tcttgcatga aaaatattcc 201 gtttgctgaa aaatggcaga acgatttgaaagcgcgcggc ttggatgcgg 251 acaatacccg tctcgccgtc gactactgca aatgtatgtgggagcagcct 301 ttggacggat tgagcgagaa acagatcagc tccttcggca aactcggtgc351 acaagaacag cttgacctgc tcggcggcgc aaacgcgttt gaaactcgag 401acaaacaatg tgtcgcggat ttgaaagccg attgaThis corresponds to the amino acid sequence <SEQ ID 1478; ORF 522.ng>:

g522.pep 1 MTEPKHETPT EEQVAARKKA KAKIRTIRIW AWVILALLAS TALLSQCAMS 51KPQAKQKIVE SCMKNIPFAE KWQNDLKARG LDADNTRLAV DYCKCMWEQP 101 LDGLSEKQISSFGKLGAQEQ LDLLGGANAF ETRDKQCVAD LKAD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1479>:

m522.seq 1 ATGACTGAGC CGAAACACGA AATGCTGACG AAAGAGCAGG TTGCCGCGCG 51CAAAAAAGCA AAAGCCAAAA TCCGCACCAT CCGCATTTGG GCGTGGGTCA 101 TTTTGGCGTTGCTCGCTTTA ACCGCCCTGC TCTCCCAATG CGCGATGTCC 151 AAACCGCAGG CAAAACAGAAAATTGTCGAG TCTTGCGTGA AGAATATTCC 201 GTTTGCCGAA AAATGGCAAA ACGATTTGCGGGCCCGCGGT TTAGATTCAA 251 ACAATACCCG CCTCGCCGTC GACTACTGCA AATGTATGTGGGAGCAGCCT 301 TTGGACAGAT TGAGCGAGAA ACAGATTAGA TCCTTCGGCA AACTCGGCGC351 ACAAGAACAG CTTGACCTGC TCGGCGGCGC AAATGCCTTT GAAGCACGTG 401ACAAGCAGTG TGTTGCCGAT TTGAAATCAG AATAAThis corresponds to the amino acid sequence <SEQ ID 1480; ORF 522>:

m522.pep 1 MTEPKHEMLT KEQVAARKKA KAKIRTIRIW AWVILALLAL TALLSQCAMS 51KPQAKQKIVE SCVKNIPFAE KWQNDLRARG LDSNNTRLAV DYCKCMWEQP 101 LDRLSEKQIRSFGKLGAQEQ LDLLGGANAF EARDKQCVAD LKSE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 522 shows 91.0% identity over a 144 aa overlap with a predicted ORF(ORF 522.ng) from N. gonorrhoeae:

m522/g522         10        20        30        40        50        60m522.pep MTEPKHEMLTKEQVAARKKAKAKIRTIRIWAWVILALLALTALLSQCAMSKPQAKQKIVE|||||||  |:|||||||||||||||||||||||||||| |||||||||||||||||||| g522MTEPKHETPTEEQVAARKKAKAKIRTIRIWAWVILALLASTALLSQCAMSKPQAKQKIVE        10        20        30        40        50        60        70        80        90       100       110       120 m522.pepSCVKNIPFAEKWQNDLRARGLDSNNTRLAVDYCKCMWEQPLDRLSEKQIRSFGKLGAQEQ||:|||||||||||||:|||||::|||||||||||||||||| |||||| |||||||||| g522SCMKNIPFAEKWQNDLKARGLDADNTRLAVDYCKCMWEQPLDGLSEKQISSFGKLGAQEQ        70        80        90       100       110       120       130       140 m522.pep LDLLGGANAFEARDKQCVADLKSEX|||||||||||:||||||||||:: g522 LDLLGGANAFETRDKQCVADLKAD       130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1481>:

a522.seq 1 ATGACTGAGC CGAAACACGA AATGCCGACG GAAGAGCAGG TTGCCGCGCG 51CAAAAAAGCA AAAGCCAAAA TCCGCACCAT CCGCATTTGG GCATGGGTCA 101 TTTTGGCGTTGCTCGCTTCA ACCGCCCTGC TCTCCCAATG CGCGATGTCC 151 AAACCGCAGG CAAAACAGAAAATTGTCGAG TCTTGCGTGA AGAATATTCC 201 GTTTGCCGAA AAATGGCAAA ACGATTTGCGGGCCCGCGGT TTAGATTCAA 251 ACAATACCCG CCTTACCGTC GACTACTGCA AATGTATGTGGGAGCAGCCT 301 TTGGACAGAT TGAGCGAGAA ACAGATTAGT TCCTTCGGCA AACTCGGCGC351 ACAAGAACAG CTTGACCTGC TCGGCGGCGC AAATGCCTTT GAAACGCGAG 401ACAAGCAGTG TGTTGCCGAT TTGAAATCAG AATAAThis corresponds to the amino acid sequence <SEQ ID 1482; ORF 522.a>:

a522.pep 1 MTEPKHEMPT EEQVAARKKA KAKIRTIRIW AWVILALLAS TALLSQCAMS 51KPQAKQKIVE SCVKNIPFAE KWQNDLRARG LDSNNTRLTV DYCKCMWEQP 101 LDRLSEKQISSFGKLGAQEQ LDLLGGANAF ETRDKQCVAD LKSE* m522/a522 95.8% identity in 144aa overlap         10        20        30        40        50        60m522.pep MTEPKHEMLTKEQVAARKKAKAKIRTIRIWAWVILALLALTALLSQCAMSKPQAKQKIVE|||||||| |:|||||||||||||||||||||||||||| |||||||||||||||||||| a522MTEPKHEMPTEEQVAARKKAKAKIRTIRIWAWVILALLASTALLSQCAMSKPQAKQKIVE        10        20        30        40        50        60        70        80        90       100       110       120 m522.pepSCVKNIPFAEKWQNDLRARGLDSNNTRLAVDYCKCMWEQPLDRLSEKQIRSFGKLGAQEQ||||||||||||||||||||||||||||:|||||||||||||||||||| |||||||||| a522SCVKNIPFAEKWQNDLRARGLDSNNTRLTVDYCKCMWEQPLDRLSEKQISSFGKLGAQEQ        70        80        90       100       110       120       130       140 m522.pep LDLLGGANAFEARDKQCVADLKSEX|||||||||||:||||||||||||| a522 LDLLGGANAFETRDKQCVADLKSEX       130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1483>:

g523.seq 1 atgactgtat ggtttgttgc cgctgttgcc gtcttaatca tcgaattatt 51gacgggaacg gtttatcttt tggttgtcag cgcggctttg gcgggttcgg 101 gcattgcctacgggctgact ggcagcacgc ctgccgccgt cttgaccgcc 151 gcactgcttt ccgcgctgggcatttggttc gtacatgcca aaaccgccgt 201 gggaaaagtt gaaacggatt catatcaggatttggatacc ggaaaatatg 251 ccgaaatcct ccgatacaca ggcggcaacc gttacgaagttttttatcgc 301 ggtacgcact ggcaggcgca aaatacgggg caggaagtgt ttgaaccggg351 aacgcgcgcc ctcatcgtcc gcaaagaagg taaccttctt atcatcgcaa 401 acccttaaThis corresponds to the amino acid sequence <SEQ ID 1484; ORF 523.ng>:

g523.pep 1 MTVWFVAAVA VLIIELLTGT VYLLVVSAAL AGSGIAYGLT GSTPAAVLTA 51ALLSALGIWF VHAKTAVGKV ETDSYQDLDT GKYAEILRYT GGNRYEVFYR 101 GTHWQAQNTGQEVFEPGTRA LIVRKEGNLL IIANP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1485>:

m523.seq (partial) 1 ..GCCGTCTTAA TCATCGAATT ATTGACGGGA ACGGTTTATCTTTTGGTTGT 51   nAGCGCGGCT TTGGCGGGTT CGGGCATTGC TTACGGGCTG ACCGGCAGTA101   CGCCTGCCGC CGTCTTGACC GnCGCTCTGC TTTCCGCGCT GGGTATTTnG 151  TTCGTACACG CCAAAACCGC CGTTAGAAAA GTTGAAACGG ATTCATATCA 201  GGATTTGGAT GCCGGACAAT ATGTCGAAAT CCTCCGACAC ACAGGCGGCA 251  ACCGTTACGA AGTTTTtTAT CGCGGTACGc ACTGGCAGGC TCAAAATACG 301  GGGCAAGAAG AGCTTGAACC AGGAACTCGC GCCCTCATTG TCCGCAAGGA 351  AGGCAACCTT CTTATTATCA CACACCCTTAAThis corresponds to the amino acid sequence <SEQ ID 1486; ORF 523>:

m523.pep (partial) 1..AVLIIELLTG TVYLLVVSAA LAGSGIAYGL TGSTPAAVLT XALLSALGIX 51   FVHAKTAVRKVETDSYQDLD AGQYVEILRH TGGNRYEVFY RGTHWQAQNT 101   GQEELEPGTR ALIVRKEGNLLIITHP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF523 shows 91.3% identity over a 126 aa overlap with a predicted ORF(ORF 523.ng) from N. gonorrhoeae:

m523/g523                  10        20        30        40        50m523.pep          AVLIIELLTGTVYLLVVSAALAGSGIAYGLTGSTPAAVLTXALLSALGIXF|||||||||||||||||||||||||||||||||||||||| |||||||| | g523MTVWFVAAVAVLIIELLTGTVYLLVVSAALAGSGIAYGLTGSTPAAVLTAALLSALGIWF        10        20        30        40        50        60       60        70        80        90       100       110 m523.pepVHAKTAVRKVETDSYQDLDAGQYVEILRHTGGNRYEVFYRGTHWQAQNTGQEELEPGTRA||||||| |||||||||||:|:|:||||:||||||||||||||||||||||| :|||||| g523VHAKTAVGKVETDSYQDLDTGKYAEILRYTGGNRYEVFYRGTHWQAQNTGQEVFEPGTRA        70        80        90       100       110       120       120m523.pep LIVRKEGNLLIITHP ||||||||||||::| g523 LIVRKEGNLLIIANPX       130The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1487>:

a523.seq 1 ATGACTGTAT GGTTTGTTGC CGCTGTTGCC GTCTTAATCA TCGAATTATT 51GACGGGAACG GTTTATCTTT TGGTTGTCAG CGCGGCTTTG GCGGGTTCGG 101 GCATTGCTTACGGGCTGACC GGCAGCACGC CTGCCGCCGT CTTGACCGCC 151 GCTCTGCTTT CCGCGCTGGGTATTTGGTTC GTACACGCCA AAACCGCCGT 201 GGGAAAAGTT GAAACGGATT CATATCAGGATTTGGATGCC GGGCAATATG 251 CCGAAATCCT CCGGCACGCA GGCGGCAACC GTTACGAAGTTTTTTATCGC 301 GGTACGCACT GGCAGGCTCA AAATACGGGG CAAGAAGAGC TTGAACCAGG351 AACGCGCGCC CTAATCGTCC GCAAGGAAGG CAACCTTCTT ATCATCGCAA 401 AACCTTAAThis corresponds to the amino acid sequence <SEQ ID 1488; ORF 523.a>:

a523.pep 1 MTVWFVAAVA VLIIELLTGT VYLLVVSAAL AGSGIAYGLT GSTPAAVLTA 51ALLSALGIWF VHAKTAVGKV ETDSYQDLDA GQYAEILRHA GGNRYEVFYR 101 GTHWQAQNTGQEELEPGTRA LIVRKEGNLL IIAKP* m523/a523 94.4% identity in 126 aa overlap                 10        20        30        40        50 m523.pep         AVLIIELLTGTVYLLVVSAALAGSGIAYGLTGSTPAAVLTXALLSALGIXF|||||||||||||||||||||||||||||||||||||||| |||||||| | a523MTVWFVAAVAVLIIELLTGTVYLLVVSAALAGSGIAYGLTGSTPAAVLTAALLSALGIWF        10        20        30        40        50        60       60        70        80        90       100       110 m523.pepVHAKTAVRKVETDSYQDLDAGQYVEILRHTGGNRYEVFYRGTHWQAQNTGQEELEPGTRA||||||| |||||||||||||||:|||||:|||||||||||||||||||||||||||||| a523VHAKTAVGKVETDSYQDLDAGQYAEILRHAGGNRYEVFYRGTHWQAQNTGQEELEPGTRA        70        80        90       100       110       120       120m523.pep LIVRKEGNLLIITHPX ||||||||||||::|| a523 LIVRKEGNLLIIAKPX       130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1489>:

g525.seq 1 atgaagtacg tccggttatt tttcctcggc acggcactcg ccggcactca 51agcggcggct gccgaaatgg ttcaaatcga aggcggcagc taccgcccgc 101 tttatctgaaaaaagatacc ggcctgatta aagtcaaacc gttcaaactg 151 gataaatatc ccgttaccaatgccgagttt gccgaatttg tcaacagcca 201 cccccaatgg caaaaaggca ggatcggttccaaacaggca gaacccgctt 251 acctgaagca ttggatgaaa aacggcagcc gcagctatgcgccgaaggcg 301 ggcgaattga aacagccggt taccaatatt tcctggtttg ccgccaacgc351 ctattgcgcc gcacaaggca aacgcctgcc gaccatcgac gaatgggaat 401ttgccggact tgcttccgcc acgcagaaaa aacggctcaa acgaacccgg 451 ctacaaccgcactattctcg attggtatgc cgacggcgga cggaaaggcc 501 tgcacgatgt cggcaaagcaccgcccgaac tactggggtg tttatgatat 551 gcacgggctg aThis corresponds to the amino acid sequence <SEQ ID 1490; ORF 525.ng>:

g525.pep 1 MKYVRLFFLG TALAGTQAAA AEMVQIEGGS YRPLYLKKDT GLIKVKPFKL 51DKYPVTNAEF AEFVNSHPQW QKGRIGSKQA EPAYLKHWMK NGSRSYAPKA 101 GELKQPVTNISWFAANAYCA AQGKRLPTID EWEFAGLASA TQKKRLKRTR 151 LQPHYSRLVC RRRTERPARCRQSTARTTGV FMICTG *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1491>:

m525.seq 1 ATGAAGTATG TCCGGTTATT TTwCCTCGGC GCGGCACTCG cCrrCACTCA 51ArCGGCGGCT GcCGAAATGG TTCAAATCGA AGGCGGCAgC TACCGCCCrC 101 TTTATCTGAAAAAAGATACC GGCCTGATTA AAGTCAAACC GTTCAAACTG 151 GATAAATATC CCGTTACCAATGCCGAGTTT GCCGAATTTG TCAACAGCCA 201 CCCCCAATGG CAAAAAGGCA GGATCGGTTCCAAACAGGCA GAACCCGCTT 251 ACCTGAAGCA TTGGATGAAA AACGGCAGCC GCAGCTATGcGCCGAAGgCG 301 GgCGAATTAA AACAACCGGT AACCAATGTT TCCTGGwTTG CCGCCAAcGC351 CTAtTGCGCC GCACAAGGCA AACGCCTGCC GACCATTGAC GAATGGGAAT 401TTGCCGGACT TGCTTCCGCC ACGCAGAAAA A.CGGCTCAA ACGAACCCGG 451 CTACAACCGCACTATTCTCG ATTGGTATGC CGACGGCGGA CGGAAAGGCC 501 TGCACGATGT CGGCA.AAGGCCGCCCGAAC TACTGGGGCG TTTATGATAT 551 GCACGGGCTG AThis corresponds to the amino acid sequence <SEQ ID 1492; ORF 525>:

m525.pep 1 MKYVRLFXLG AALAXTQXAA AEMVQIEGGS YRPLYLKKDT GLIKVKPFKL 51DKYPVTNAEF AEFVNSHPQW QKGRIGSKQA EPAYLKHWMK NGSRSYAPKA 101 GELKQPVTNVSWXAANAYCA AQGKRLPTID EWEFAGLASA TQKXRLKRTR 151 LQPHYSRLVC RRRTERPARCRXKAARTTGA FMICTG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 525 shows 94.1% identity over a 186 aa overlap with a predicted ORF(ORF 525.ng) from N. gonorrhoeae:

m525/g525         10        20        30        40        50        60m525.pep MKYVRLFXLGAALAXTQXAAAEMVQIEGGSYRPLYLKKDTGLIKVKPFKLDKYPVTNAEF||||||| ||:||| || |||||||||||||||||||||||||||||||||||||||||| g525MKYVRLFFLGTALAGTQAAAAEMVQIEGGSYRPLYLKKDTGLIKVKPFKLDKYPVTNAEF        10        20        30        40        50        60        70        80        90       100       110       120 m525.pepAEFVNSHPQWQKGRIGSKQAEPAYLKHWMKNGSRSYAPKAGELKQPVTNVSWXAANAYCA|||||||||||||||||||||||||||||||||||||||||||||||||:|| ||||||| g525AEFVNSHPQWQKGRIGSKQAEPAYLKHWMKNGSRSYAPKAGELKQPVTNISWFAANAYCA        70        80        90       100       110       120       130       140       150       160       170       180 m525.pepAQGKRLPTIDEWEFAGLASATQKXRLKRTRLQPHYSRLVCRRRTERPARCRXKAARTTGA||||||||||||||||||||||| ||||||||||||||||||||||||||| ::|||||: g525AQGKRLPTIDEWEFAGLASATQKKRLKRTRLQPHYSRLVCRRRTERPARCRQSTARTTGV       130       140       150       160       170       180 m525.pepFMICTGX ||||||| g525 FMICTGXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1493>:

a525.seq 1 ATGAAGTTTA CCCGGTTACT CTTTCTCTGT GCGGCACTCG CCGGCACTCA 51AGCGGCAGCT GCCGAAATGG TTCAAATCGA AGGCGGCAGC TACCGCCCGC 101 TTTATCTGAAAAAAGATACC GGCCTGATTA AAGTCAAACC GTTCAAACTG 151 GATAAATATC CCGTTACCAATGCCGAGTTT GCCGAATTTG TCAACAGCCA 201 CCCCCAATGG CAAAAAGGCA GGATCGGTTCCAAACAGGCA GAACCCGCTT 251 ACCTGAAGCA TTGGATGAAA AACGGCAGCC GCAGCTATGCGCCGAAGGCG 301 GGCGATTTAA AACAACCGGT AACCAATGTT TCCTGGTTCG CCGCCAACGC351 CTATTGCGCC GCACAAGGCA AACGCCTGCC GACCATTGAC GAATGGGAAT 401TTGCCGGACT TGCCTCCGCC ACGCAG.AAA AACGGCTCAA ACGAACCCGG 451 CTACAACCGCACTATTCTCG ACTGGTATGC GGATGGCGAC CGGAAAGACC 501 TGCACGATGT CGGCAAAG.GTCGCCCGAAC TACTGGGGCG TTTATGATAT 551 GCACGGTCTG AThis corresponds to the amino acid sequence <SEQ ID 1494; ORF 525.a>:

a525.pep 1 MKFTRLLFLC AALAGTQAAA AEMVQIEGGS YRPLYLKKDT GLIKVKPFKL 51DKYPVTNAEF AEFVNSHPQW QKGRIGSKQA EPAYLKHWMK NGSRSYAPKA 101 GDLKQPVTNVSWFAANAYCA AQGKRLPTID EWEFAGLASA TQXKRLKRTR 151 LQPHYSRLVC GWRPERPARCRQXVARTTGA FMICTV* m525/a525 90.8% identity in 185 aa overlap        10        20        30        40        50        60 m525.pepMKYVRLFXLGAALAXTQXAAAEMVQIEGGSYRPLYLKKDTGLIKVKPFKLDKYPVTNAEF ||::||:| |||| || |||||||||||||||||||||||||||||||||||||||||| a525MKFTRLLFLCAALAGTQAAAAEMVQIEGGSYRPLYLKKDTGLIKVKPFKLDKYPVTNAEF        10        20        30        40        50        60        70        80        90       100       110       120 m525.pepAEFVNSHPQWQKGRIGSKQAEPAYLKHWMKNGSRSYAPKAGELKQPVTNVSWXAANAYCA|||||||||||||||||||||||||||||||||||||||||:|||||||||| ||||||| a525AEFVNSHPQWQKGRIGSKQAEPAYLKHWMKNGSRSYAPKAGDLKQPVTNVSWFAANAYCA        70        80        90       100       110       120       130       140       150       160       170       180 m525.pepAQGKRLPTIDEWEFAGLASATQKXRLKRTRLQPHYSRLVCRRRTERPARCRXKAARTTGA||||||||||||||||||||||  ||||||||||||||||  | |||||||  :|||||| a525AQGKRLPTIDEWEFAGLASATQXKRLKRTRLQPHYSRLVCGWRPERPARCRQXVARTTGA       130       140       150       160       170       180 m525.pepFMICTGX ||||| a525 FMICTVXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1495>:

g525-1.seq 1 ATGAAGTACG TCCGGTTATT TTTCCTCGGC ACGGCACTCG CCGGCACTCA 51AGCGGCGGCT GCCGAAATGG TTCAAATCGA AGGCGGCAGC TACCGCCCGC 101 TTTATCTGAAAAAAGATACC GGCCTGATTA AAGTCAAACC GTTCAAACTG 151 GATAAATATC CCGTTACCAATGCCGAGTTT GCCGAATTTG TCAACAGCCA 201 CCCCCAATGG CAAAAAGGCA GGATCGGTTCCAAACAGGCA GAACCCGCTT 251 ACCTGAAGCA TTGGATGAAA AACGGCAGCC GCAGCTATGCGCCGAAGGCG 301 GGCGAATTGA AACAGCCGGT TACCAATATT TCCTGGTTTG CCGCCAACGC351 CTATTGCGCC GCACAAGGCA AACGCCTGCC GACCATCGAC GAATGGGAAT 401TTGCCGGACT TGCTTCCGCC ACGCAGAAAA ACGGCTCAAA CGAACCCGGC 451 TACAACCGCACTATTCTCGA TTGGTATGCC GACGGCGGAC GGAAAGGCCT 501 GCACGATGTC GGCAAAGACCGCCCGAACTA CTGGGGTGTT TATGATATGC 551 ACGGGCTGAT TTGGGAATGG ACGGAAGATTTCAACAGCAG CCTGCTTTCT 601 TCCGGCAATG CCAACGCGCA AATGTTTTGC AGCGGCGCATCTGTCGGGGC 651 GAGCGACTCG TCCAACTATG CCGCCTTCCT CCGCTACGGC ATCCGCACCA701 GCCTGCAATC CAAATACGTC CTGCACAACT TGGGCTTCCG CTGCGCAAGC 751 CGATAAThis corresponds to the amino acid sequence <SEQ ID 1496; ORF 525-1.ng>:

g525-1.pep 1 MKYVRLFFLG TALAGTQAAA AEMVQIEGGS YRPLYLKKDT GLIKVKPFKL 51DKYPVTNAEF AEFVNSHPQW QKGRIGSKQA EPAYLKHWMK NGSRSYAPKA 101 GELKQPVTNISWFAANAYCA AQGKRLPTID EWEFAGLASA TQKNGSNEPG 151 YNRTILDWYA DGGRKGLHDVGKDRPNYWGV YDMHGLIWEW TEDFNSSLLS 201 SGNANAQMFC SGASVGASDS SNYAAFLRYGIRTSLQSKYV LHNLGFRCAS 251 R*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1497>:

m525-1.seq 1 ATGAAGTATG TCCGGTTATT TTTCCTCGGC GCGGCACTCG CCGGCACTCA 51AGCGGCGGCT GCCGAAATGG TTCAAATCGA AGGCGGCAGC TACCGCCCGC 101 TTTATCTGAAAAAAGATACC GGCCTGATTA AAGTCAAACC GTTCAAACTG 151 GATAAATATC CCGTTACCAATGCCGAGTTT GCCGAATTTG TCAACAGCCA 201 CCCCCAATGG CAAAAAGGCA GGATCGGTTCCAAACAGGCA GAACCCGCTT 251 ACCTGAAGCA TTGGATGAAA AACGGCAGCC GCAGCTATGCGCCGAAGGCG 301 GGCGAATTAA AACAACCGGT AACCAATGTT TCCTGGTTTG CCGCCAACGC351 CTATTGCGCC GCACAAGGCA AACGCCTGCC GACCATTGAC GAATGGGAAT 401TTGCCGGACT TGCTTCCGCC ACGCAGAAAA ACGGCTCAAA CGAACCCGGC 451 TACAACCGCACTATTCTCGA TTGGTATGCC GACGGCGGAC GGAAAGGCCT 501 GCACGATGTC GGCAAAGGCCGCCCGAACTA CTGGGGCGTT TATGATATGC 551 ACGGGCTGAT TTGGGAATGG ACGGAAGATTTCAACAGCAG CCTGCTTTCT 601 TCCGGCAATG CCAACGCGCA AATGTTTTGC AGCGGCGCGTCTATCGGGTC 651 GAGCGACTCG TCCAACTATG CCGCCTTCCT CCGCTACGGC ATCCGTACCA701 GCCTGCAATC CAAATATGTC TTGCACAACT TGGGCTTCCG TTGCACAAGC 751 CGATAAThis corresponds to the amino acid sequence <SEQ ID 1498; ORF 525-1>:

m525-1.pep 1 MKYVRLFFLG AALAGTQAAA AEMVQIEGGS YRPLYLKKDT GLIKVKPFKL 51DKYPVTNAEF AEFVNSHPQW QKGRIGSKQA EPAYLKHWMK NGSRSYAPKA 101 GELKQPVTNVSWFAANAYCA AQGKRLPTID EWEFAGLASA TQKNGSNEPG 151 YNRTILDWYA DGGRKGLHDVGKGRPNYWGV YDMHGLIWEW TEDFNSSLLS 201 SGNANAQMFC SGASIGSSDS SNYAAFLRYGIRTSLQSKYV LHNLGFRCTS 251 R* m525-1/g525-1 97.6% identity in 251 aaoverlap         10        20        30        40        50        60m525-1.pep MKYVRLFFLGAALAGTQAAAAEMVQIEGGSYRPLYLKKDTGLIKVKPFKLDKYPVTNAEF||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||| g525-1MKYVRLFFLGTALAGTQAAAAEMVQIEGGSYRPLYLKKDTGLIKVKPFKLDKYPVTNAEF        10        20        30        40        50        60        70        80        90       100       110       120 m525-1.pepAEFVNSHPQWQKGRIGSKQAEPAYLKHWMKNGSRSYAPKAGELKQPVTNVSWFAANAYCA|||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||| g525-1AEFVNSHPQWQKGRIGSKQAEPAYLKHWMKNGSRSYAPKAGELKQPVTNISWFAANAYCA        70        80        90       100       110       120       130       140       150       160       170       180 m525-1.pepAQGKRLPTIDEWEFAGLASATQKNGSNEPGYNRTILDWYADGGRKGLHDVGKGRPNYWGV|||||||||||||||||||||||||||||||||||||||||||||||||||| ||||||| g525-1AQGKRLPTIDEWEFAGLASATQKNGSNEPGYNRTILDWYADGGRKGLHDVGKDRPNYWGV       130       140       150       160       170       180       190       200       210       220       230       240 m525-1.pepYDMHGLIWEWTEDFNSSLLSSGNANAQMFCSGASIGSSDSSNYAAFLRYGIRTSLQSKYV||||||||||||||||||||||||||||||||||:|:||||||||||||||||||||||| g525-1YDMHGLIWEWTEDFNSSLLSSGNANAQMFCSGASVGASDSSNYAAFLRYGIRTSLQSKYV       190       200       210       220       230       240        250m525-1.pep LHNLGFRCTSRX ||||||||:||| g525-1 LHNLGFRCASRX        250The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1499>:

a525-1.seq 1 ATGAAGTTTA CCCGGTTACT CTTTCTCTGT GCGGCACTCG CCGGCACTCA 51AGCGGCAGCT GCCGAAATGG TTCAAATCGA AGGCGGCAGC TACCGCCCGC 101 TTTATCTGAAAAAAGATACC GGCCTGATTA AAGTCAAACC GTTCAAACTG 151 GATAAATATC CCGTTACCAATGCCGAGTTT GCCGAATTTG TCAACAGCCA 201 CCCCCAATGG CAAAAAGGCA GGATCGGTTCCAAACAGGCA GAACCCGCTT 251 ACCTGAAGCA TTGGATGAAA AACGGCAGCC GCAGCTATGCGCCGAAGGCG 301 GGCGATTTAA AACAACCGGT AACCAATGTT TCCTGGTTCG CCGCCAACGC351 CTATTGCGCC GCACAAGGCA AACGCCTGCC GACCATTGAC GAATGGGAAT 401TTGCCGGACT TGCCTCCGCC ACGCAGAAAA ACGGCTCAAA CGAACCCGGC 451 TACAACCGCACTATTCTCGA CTGGTATGCG GATGGCGACC GGAAAGACCT 501 GCACGATGTC GGCAAAGGTCGCCCGAACTA CTGGGGCGTT TATGATATGC 551 ACGGTCTGAT TTGGGAATGG ACGGAAGATTTCAACAGCAG CCTGCTTTCT 601 TCCGGCAATG CCAACGCGCA AATGTTTTGC AGCGGCGCGTCTATCGGGTC 651 GAGCGACTCG TCCAACTATG CCGCCTTCCT CCGCTACGGC ATCCGCACCA701 GCCTGCAATC CAAATATGTC TTGCACAACT TGGGCTTCCG TTGCACAAGC 751 CGATAAThis corresponds to the amino acid sequence <SEQ ID 1500; ORF 525-1.a>:

a525-1.pep 1 MKFTRLLFLC AALAGTQAAA AEMVQIEGGS YRPLYLKKDT GLIKVKPFKL 51DKYPVTNAEF AEFVNSHPQW QKGRIGSKQA EPAYLKHWMK NGSRSYAPKA 101 GDLKQPVTNVSWFAANAYCA AQGKRLPTID EWEFAGLASA TQKNGSNEPG 151 YNRTILDWYA DGDRKDLHDVGKGRPNYWGV YDMHGLIWEW TEDFNSSLLS 201 SGNANAQMFC SGASIGSSDS SNYAAFLRYGIRTSLQSKYV LHNLGFRCTS 251 R* m525-1/a525-1 97.2% identity in 251 aaoverlap         10        20        30        40        50        60m525-1.pep MKYVRLFFLGAALAGTQAAAAEMVQIEGGSYRPLYLKKDTGLIKVKPFKLDKYPVTNAEF||::||:|| |||||||||||||||||||||||||||||||||||||||||||||||||| a525-1MKFTRLLFLCAALAGTQAAAAEMVQIEGGSYRPLYLKKDTGLIKVKPFKLDKYPVTNAEF        10        20        30        40        50        60        70        80        90       100       110       120 m525-1.pepAEFVNSHPQWQKGRIGSKQAEPAYLKHWMKNGSRSYAPKAGELKQPVTNVSWFAANAYCA|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| a525-1AEFVNSHPQWQKGRIGSKQAEPAYLKHWMKNGSRSYAPKAGDLKQPVTNVSWFAANAYCA        70        80        90       100       110       120       130       140       150       160       170       180 m525-1.pepAQGKRLPTIDEWEFAGLASATQKNGSNEPGYNRTILDWYADGGRKGLHDVGKGRPNYWGV|||||||||||||||||||||||||||||||||||||||||| || |||||||||||||| a525-1AQGKRLPTIDEWEFAGLASATQKNGSNEPGYNRTILDWYADGDRKDLHDVGKGRPNYWGV       130       140       150       160       170       180       190       200       210       220       230       240 m525-1.pepYDMHGLIWEWTEDFNSSLLSSGNANAQMFCSGASIGSSDSSNYAAFLRYGIRTSLQSKYV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a525-1YDMHGLIWEWTEDFNSSLLSSGNANAQMFCSGASIGSSDSSNYAAFLRYGIRTSLQSKYV       190       200       210       220       230       240        250m525-1.pep LHNLGFRCTSRX |||||||||||| a525-1 LHNLGFRCTSRX        250The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1501>:

g527.seq 1 atggttttac cagtctcctt ttttcagcct gtccagttgg cggcggtcgc 51gcttggtcgg tctgccgtcg ggatgggcgg aagtgatgcg gctgaattgg 101 tcgagctgtttgcactcttc cctcaatgct gccgttttcg cgtcttcttc 151 atacagaagc cgcgcctcgggtgccgggcg gcgttggtgg ttcaaacctt 201 taaccttgat tttatgggga agggaattgagcgtcaggtc gataatatcg 251 ccgatgtcta tggttttact gtttttgact ttcgagccgtttacttgaac 301 cctacccagt tcgatatgct tttgcgcaag ggaacgggtc ttgaaaaaac351 gtgccgccca aagccatttg tccagccgca tggcggaaga atcgtgcttg 401tctttcatac gattttgttt gaaataattg aatttgtttc gagtttagca 451 taaThis corresponds to the amino acid sequence <SEQ ID 1502; ORF 527.ng>:

g527.pep 1 MVLPVSFFQP VQLAAVALGR SAVGMGGSDA AELVELFALF PQCCRFRVFF 51IQKPRLGCRA ALVVQTFNLD FMGKGIERQV DNIADVYGFT VFDFRAVYLN 101 PTQFDMLLRKGTGLEKTCRP KPFVQPHGGR IVLVFHTILF EIIEFVSSLA 151 *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1503>:

m527.seq 1 ATGGTTTTAC CAGTCTCCTT TTTTCAGCCT GTCCAGTTGG CGGCGGTCGC 51GCTTGGTCGG TCTGCCGTCG GGATAGGCGG AAGTGATGCG GCTGAATTGG 101 TCGAGCTGTTTGCGCTCTTC CCTCAATGTT GCCGTTwTCG CGTCCTCTTC 151 ATACAGAAGC CGCGCyTCGGATGCCGGGCG GCGTTGGTGG TTCAAACCTT 201 TAACCkTGAT TTTATAGGGA AGGG.AATTkAgCkTCaGTy GrTwATaTCG 251 CsGATGTmTA TGGTTTTACT GTTTTTGACC TTCGAGCCGTTTACTTGAAC 301 CCTACCCAGT TCGATGTGCT TTTGCGCAAG GGAACGGGTC TTGAAAAAAC351 GTGCCGCCCA AAGCCATTTG TCCAGCCGCA TGGCGGAAGA ATCGTGCTTG 401TCTTTCATAC GATTTTGTTT GAAATAATTG AATTTGTTTC GAGTTTAGCA 451 TAAThis corresponds to the amino acid sequence <SEQ ID 1504; ORF 527>:

m527pep 1 MVLPVSFFQP VQLAAVALGR SAVGIGGSDA AELVELFALF PQCCRXRVLF 51IQKPRXGCRA ALVVQTFNXD FIGKXNXASV XXIADVYGFT VFDLRAVYLN 101 PTQFDVLLRKGTGLEKTCRP KPFVQPHGGR IVLVFHTILF EIIEFVSSLA 151 *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 527 shows 90.0% identity over a 150 aa overlap with a predicted ORF(ORF 527.ng) from N. gonorrhoeae:

m527/g527         10        20        30        40        50        60m527.pep MVLPVSFFQPVQLAAVALGRSAVGIGGSDAAELVELFALFPQCCRXRVLFIQKPRXGCRA||||||||||||||||||||||||:|||||||||||||||||||| ||:|||||| |||| g527MVLPVSFFQPVQLAAVALGRSAVGMGGSDAAELVELFALFPQCCRFRVFFIQKPRLGCRA        10        20        30        40        50        60        70        80        90       100       110       120 m527.pepALVVQTFNXDFIGKXNXASVXXIADVYGFTVFDLRAVYLNPTQFDVLLRKGTGLEKTCRP|||||||| ||:||    :|  |||||||||||:|||||||||||:|||||||||||||| g527ALVVQTFNLDFMGKGIERQVDNIADVYGFTVFDFRAVYLNPTQFDMLLRKGTGLEKTCRP        70        80        90       100       110       120       130       140       150 m527.pep KPFVQPHGGRIVLVFHTILFEIIEFVSSLA|||||||||||||||||||||||||||||| g527 KPFVQPHGGRIVLVFHTILFEIIEFVSSLA       130       140       150The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1505>:

a527.seq 1 ATGGTTTTAC CAGTCTCCTT TTTTCAGCCT GTCCAGTTGG CGGCGGTCGC 51GCTTGGTCGG TCTGCCGTCG GGATAGGCGG AAGTGATGCG GCTGAATTGG 101 TCGAGCTGTTTGCGCTCTTC CCTCAATGTT GCCGTTTTCG CGTCCTCTTC 151 ATACAGAAGC CGCGCCTCGGATGCCGGGCG GCGTTGGTGG TTCAAACCTT 201 TAACCTTGAT TTTATAGGGA AGGGAATTGAGCGTCAGGTC GATAATATCG 251 CCGATGTCTA TGGTTTTACT GTTTTTGACC TTCGAGCCGTTTACTTGAAC 301 CCTACCCAGT TCGATGTGCT TTTGCGCAAG GGAACGGGTC TTGAAAAAAC351 GTGCCGCCCA AAGCCATTTG TCCAGCCGCA TGGCGGAAGA ATCGTGCTTG 401TCTTTCATAC GATTTTGTTT GAAATAATTG AATTTGTTTC GAGTTTAGCA 451 TAAThis corresponds to the amino acid sequence <SEQ ID 1506; ORF 527.a>:

a527.pep 1 MVLPVSFFQP VQLAAVALGR SAVGIGGSDA AELVELFALF PQCCRFRVLF 51IQKPRLGCRA ALVVQTFNLD FIGKGIERQV DNIADVYGFT VFDLRAVYLN 101 PTQFDVLLRKGTGLEKTCRP KPFVQPHGGR IVLVFHTILF EIIEFVSSLA 151 * m527/a527 93.3%identity in 150 aa overlap        10        20        30        40        50        60 m527.pepMVLPVSFFQPVQLAAVALGRSAVGIGGSDAAELVELFALFPQCCRXRVLFIQKPRXGCRA||||||||||||||||||||||||||||||||||||||||||||| ||||||||| |||| a527MVLPVSFFQPVQLAAVALGRSAVGIGGSDAAELVELFALFPQCCRFRVLFIQKPRLGCRA        10        20        30        40        50        60        70        80        90       100       110       120 m527.pepALVVQTFNXDFIGKXNXASVXXIADVYGFTVFDLRAVYLNPTQFDVLLRKGTGLEKTCRP|||||||| |||||    :|  |||||||||||||||||||||||||||||||||||||| a527ALVVQTFNLDFIGKGIERQVDNIADVYGFTVFDLRAVYLNPTQFDVLLRKGTGLEKTCRP        70        80        90       100       110       120       130       140       150 m527.pep KPFVQPHGGRIVLVFHTILFEIIEFVSSLAX||||||||||||||||||||||||||||||| a527 KPFVQPHGGRIVLVFHTILFEIIEFVSSLAX       130       140       150The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1507>:

g528.seq 1 atggaaattc gggtaataaa atatacggca acggctgcgt tgtttgcatt 51tacggttgca ggctgccggc tggcggggtg gtatgagtgt ttgtccttgt 101 ccggctggtgtaagccgaga aaacctgccg ccatcgattt ttgggatatt 151 ggcggcgaga gtccgctgtctttagaggac tacgagatac cgctttcaga 201 cggcaatcgt tccgtcaggg caaacgaatatgaatccgcg caaaaatctt 251 acttttatag gaaaataggg aagtttgaag cctgcgggttggattggcgt 301 acgcgtgacg gcaaaccttt ggttgagagg ttcaaacagg aaggtttcga351 ctgtttggaa aagcaggggt tgcggcgcaa cggcctgtcc gagcgcgtcc 401 gatggtaaThis corresponds to the amino acid sequence <SEQ ID 1508; ORF 528.ng>:

g528.pep 1 MEIRVIKYTA TAALFAFTVA GCRLAGWYEC LSLSGWCKPR KPAAIDFWDI 51GGESPLSLED YEIPLSDGNR SVRANEYESA QKSYFYRKIG KFEACGLDWR 101 TRDGKPLVERFKQEGFDCLE KQGLRRNGLS ERVRW*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1509>:

m528.seq (partial) 1 ATGGAAATTC GGGCAATAAA ATATACGGCA ATGGCTGCGTTGCTTGCATT 51 TACGGTTGCA GGCTGCCGGC TGGCGGGGTG GTATGAGTGT TCGTCCCTCA 101CCGGCTGGTG TAAGCCGAGA AAACCGGCTG CCATCGATTT TTGGGATATT 151 GGCGGCGAGAGTCCGCCGTC TTTAGGGGAC TACGAGATAC CGCTTTCAGA 201 CGGCAATAGT TCCGTCAGGGCAAACGAATA TGAATCCGCA CAACAATCTT 251 ACTTTTACAG GAAAATAGGG AAGTTTGAAGC.TGCGGGCT GGATTGGCGT 301 ACGCGTGACG GCAAACCTTT GATTGAGACG TTCAAACAGGGAGGATTTGA 351 CTGCTTGGAA AAG....This corresponds to the amino acid sequence <SEQ ID 1510; ORF 528>:

m528.pep (partial) 1 MEIRAIKYTA MAALLAFTVA GCRLAGWYEC SSLTGWCKPRKPAAIDFWDI 51 GGESPPSLGD YEIPLSDGNS SVRANEYESA QQSYFYRKIG KFEXCGLDWR 101TRDGKPLIET FKQGGFDCLE K....Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 528 shows 89.3% identity over a 121 aa overlap with a predicted ORF(ORF 528.ng) from N. gonorrhoeae:

m528/g528         10        20        30        40        50        60m528.pep MEIRAIKYTAMAALLAFTVAGCRLAGWYECSSLTGWCKPRKPAAIDFWDIGGESPPSLGD||||:||||| |||:||||||||||||||| ||:||||||||||||||||||||| || | g528MEIRVIKYTATAALFAFTVAGCRLAGWYECLSLSGWCKPRKPAAIDFWDIGGESPLSLED        10        20        30        40        50        60        70        80        90       100       110       120 m528.pepYEIPLSDGNSSVRANEYESAQQSYFYRKIGKFEXCGLDWRTRDGKPLIETFKQGGFDCLE||||||||| |||||||||||:||||||||||| |||||||||||||:| ||| |||||| g528YEIPLSDGNRSVRANEYESAQKSYFYRKIGKFEACGLDWRTRDGKPLVERFKQEGFDCLE        70        80        90       100       110       120 m528.pep K| g528 KQGLRRNGLSERVRWThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1511>:

a528.seq 1 ATGGAAATTC GGGCAATAAA ATATACGGCA ATGGCTGCGT TGCTTGCATT 51TACGGTTGCA GGCTGCCGGT TGGCAGGTTG GTATGAGTGT TCGTCCCTGT 101 CCGGCTGGTGTAAGCCGAGA AAACCTGCCG CCATCGATTT TTGGGATATT 151 GGCGGCGAGA GTCCTCCGTCTTTAGAGGAC TACGAGATAC CGCTTTCAGA 201 CGGCAATCGT TCCGTCAGGG CAAACGAATATGAATCCGCA CAACAATCTT 251 ACTTTTACAG GAAAATAGGG AAGTTTGAAG CCTGCGGGTTGGATTGGCGT 301 ACGCGTGACG GCAAACCTTT GATTGAGACG TTCAAACAGG AAGGTTTTGA351 TTGTTTGAAA AAGCAGGGGT TGCGGCGCAA CGGTCTGTCC GAGCGCGTCC 401 GATGGTAAThis corresponds to the amino acid sequence <SEQ ID 1512; ORF 528.a>:

a528.pep 1 MEIRAIKYTA MAALLAFTVA GCRLAGWYEC SSLSGWCKPR KPAAIDFWDI 51GGESPPSLED YEIPLSDGNR SVRANEYESA QQSYFYRKIG KFEACGLDWR 101 TRDGKPLIETFKQEGFDCLK KQGLRRNGLS ERVRW* m528/a528 95.0% identity in 121 aa overlap        10        20        30        40        50        60 m528.pepMEIRAIKYTAMAALLAFTVAGCRLAGWYECSSLTGWCKPRKPAAIDFWDIGGESPPSLGD|||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| | a528MEIRAIKYTAMAALLAFTVAGCRLAGWYECSSLSGWCKPRKPAAIDFWDIGGESPPSLED        10        20        30        40        50        60        70        80        90       100       110       120 m528.pepYEIPLSDGNSSVRANEYESAQQSYFYRKIGKFEXCGLDWRTRDGKPLIETFKQGGFDCLE||||||||| ||||||||||||||||||||||| ||||||||||||||||||| |||||: a528YEIPLSDGNRSVRANEYESAQQSYFYRKIGKFEACGLDWRTRDGKPLIETFKQEGFDCLK        70        80        90       100       110       120 m528.pep K| a528 KQGLRRNGLSERVRWX        130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1513>:

g528-1.seq

g528-1.seq 1 ATGGAAATTC GGGTAATAAA ATATACGGCA ACGGCTGCGT TGTTTGCATT 51TACGGTTGCA GGCTGCCGGC TGGCGGGGTG GTATGAGTGT TCGTCCTTGT 101 CCGGCTGGTGTAAGCCGAGA AAACCTGCCG CCATCGATTT TTGGGATATT 151 GGCGGCGAGA GTCCGCTGTCTTTAGAGGAC TACGAGATAC CGCTTTCAGA 201 CGGCAATCGT TCCGTCAGGG CAAACGAATATGAATCCGCG CAAAAATCTT 251 ACTTTTATAG GAAAATAGGG AAGTTTGAAG CCTGCGGGTTGGATTGGCGT 301 ACGCGTGACG GCAAACCTTT GGTTGAGAGG TTCAAACAGG AAGGTTTCGA351 CTGTTTGGAA AAGCAGGGGT TGCGGCGCAA CGGCCTGTCC GAGCGCGTCC 401 GATGGTAAThis corresponds to the amino acid sequence <SEQ ID 1514; ORF 528-1.ng>:

g528-1.pep 1 MEIRVIKYTA TAALFAFTVA GCRLAGWYEC SSLSGWCKPR KPAAIDFWDI 51GGESPLSLED YEIPLSDGNR SVRANEYESA QKSYFYRKIG KFEACGLDWR 101 TRDGKPLVERFKQEGFDCLE KQGLRRNGLS ERVRW*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1515>:

m528-1.seq 1 ATGGAAATTC GGGCAATAAA ATATACGGCA ATGGCTGCGT TGCTTGCATT 51TACGGTTGCA GGCTGCCGGC TGGCGGGGTG GTATGAGTGT TCGTCCCTCA 101 CCGGCTGGTGTAAGCCGAGA AAACCGGCTG CCATCGATTT TTGGGATATT 151 GGCGGCGAGA GTCCGCCGTCTTTAGGGGAC TACGAGATAC CGCTTTCAGA 201 CGGCAATCGT TCCGTCAGGG CAAACGAATATGAATCCGCA CAACAATCTT 251 ACTTTTACAG GAAAATAGGG AAGTTTGAAG CCTGCGGGCTGGATTGGCGT 301 ACGCGTGACG GCAAACCTTT GATTGAGACG TTCAAACAGG GAGGATTTGA351 CTGCTTGGAA AAGCAGGGGT TGCGGCGCAA CGGTCTGTCC GAGCGCGTCC 401 GATGGTAAThis corresponds to the amino acid sequence <SEQ ID 1516; ORF 528-1>:

m528-1.pep.. 1 MEIRAIKYTA MAALLAFTVA GCRLAGWYEC SSLTGWCKPR KPAAIDFWDI 51GGESPPSLGD YEIPLSDGNR SVRANEYESA QQSYFYRKIG KFEACGLDWR 101 TRDGKPLIETFKQGGFDCLE KQGLRRNGLS ERVRW* g528-1/m528-1 92.6% identity in 135 aaoverlap         10        20        30        40        50        60g528-1.pep MEIRVIKYTATAALFAFTVAGCRLAGWYECSSLSGWCKPRKPAAIDFWDIGGESPLSLED||||:||||| |||:||||||||||||||||||:||||||||||||||||||||| || | m528-1MEIRAIKYTAMAALLAFTVAGCRLAGWYECSSLTGWCKPRKPAAIDFWDIGGESPPSLGD        10        20        30        40        50        60        70        80        90       100       110       120 g528-1.pepYEIPLSDGNRSVRANEYESAQKSYFYRKIGKFEACGLDWRTRDGKPLVERFKQEGFDCLE|||||||||||||||||||||:|||||||||||||||||||||||||:| ||| |||||| m528-1YEIPLSDGNRSVRANEYESAQQSYFYRKIGKFEACGLDWRTRDGKPLIETFKQGGFDCLE        70        80        90       100       110       120        130g528-1.pep KQGLRRNGLSERVRWX |||||||||||||||| m528-1 KQGLRRNGLSERVRWX       130The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1517>:

a528-1.seq 1 ATGGAAATTC GGGCAATAAA ATATACGGCA ATGGCTGCGT TGCTTGCATT 51TACGGTTGCA GGCTGCCGGT TGGCAGGTTG GTATGAGTGT TCGTCCCTGT 101 CCGGCTGGTGTAAGCCGAGA AAACCTGCCG CCATCGATTT TTGGGATATT 151 GGCGGCGAGA GTCCTCCGTCTTTAGAGGAC TACGAGATAC CGCTTTCAGA 201 CGGCAATCGT TCCGTCAGGG CAAACGAATATGAATCCGCA CAACAATCTT 251 ACTTTTACAG GAAAATAGGG AAGTTTGAAG CCTGCGGGTTGGATTGGCGT 301 ACGCGTGACG GCAAACCTTT GATTGAGACG TTCAAACAGG AAGGTTTTGA351 TTGTTTGAAA AAGCAGGGGT TGCGGCGCAA CGGTCTGTCC GAGCGCGTCC 401 GATGGTAAThis corresponds to the amino acid sequence <SEQ ID 1518; ORF 528-1.a>:

a528-1.pep 1 MEIRAIKYTA MAALLAFTVA GCRLAGWYEC SSLSGWCKPR KPAAIDFWDI 51GGESPPSLED YEIPLSDGNR SVRANEYESA QQSYFYRKIG KFEACGLDWR 101 TRDGKPLIETFKQEGFDCLK KQGLRRNGLS ERVRW* a528-1/m528-1 97.0% identity in 135 aaoverlap         10        20        30        40        50        60a528-1.pep MEIRAIKYTAMAALLAFTVAGCRLAGWYECSSLSGWCKPRKPAAIDFWDIGGESPPSLED|||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| | m528-1MEIRAIKYTAMAALLAFTVAGCRLAGWYECSSLTGWCKPRKPAAIDFWDIGGESPPSLGD        10        20        30        40        50        60        70        80        90       100       110       120 a528-1.pepYEIPLSDGNRSVRANEYESAQQSYFYRKIGKFEACGLDWRTRDGKPLIETFKQEGFDCLK||||||||||||||||||||||||||||||||||||||||||||||||||||| |||||: m528-1YEIPLSDGNRSVRANEYESAQQSYFYRKIGKFEACGLDWRTRDGKPLIETFKQGGFDCLE        70        80        90       100       110       120        130a528-1.pep KQGLRRNGLSERVRWX |||||||||||||||| m528-1 KQGLRRNGLSERVRWX       130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1519>:

g529.seq (partial) 1 atgacccata tcaaacccgt cattgccgcg ctcgcactcatcgggcttgc 51 cgcctgctcc ggcagcaaaa ccgaacagcc caagctcgac taccaaagcc 101ggtcgcaccg cctgatcaaa ctcgaagtcc cgcctgattt gaacaacccc 151 gaccaaggcaacctctaccg cctgcctgcc ggttcgggag ccgtccgcgc 201 cggggatttg gaaaaacgccgcacacccgc cgtccaacag ccagcggatg 251 ccggaagtat tgaaaagcgt caaaggcgtccgcttcgagc ggcgacggca 301 gccaacgcct ggcttgtcgt tgacggcaaa tcccccgccgaaatctccgc 351 cgctttctg.This corresponds to the amino acid sequence <SEQ ID 1520; ORF 529.ng>:

g529.pep (partial) 1 MTHIKPVIAA LALIGLAACS GSKTEQPKLD YQSRSHRLIKLEVPPDLNNP 51 DQGNLYRLPA GSGAVRAGDL EKRRTPAVQQ PADAGSIEKR QRRPLRAATA 101ANAWLVVDGK SPAEISAAF..The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1521>:

m529.seq 1 ATGACCCATA TCAAACCCGT CATTGCCGCG CTCGCACTCA TCGGGCTTGC 51CGCCTGCTCC GGCAGCAAAA CCGAACAGCC CAAGCTCGAC TACCAAAGCC 101 GGTCGCACCGCCTGATCAAA CTTGAAGTCC CACCTGATTT GAAAAACGCC 151 GACCAAGGCA ACCTCTACCGCCTGCCTGCC GGTTCGGGCG CCGTCCGCGC 201 CAGCGATTTG GAAAAACGCC GCACACCCGCCGTCCAACAG CCTGCCGATG 251 CCGAAGTATT GAAAAGCGTC AAAGGTGTCC GCCTCGAGCGCGACGGCAGC 301 CAACGCTGGC TCGTTGTCGA CGGCAAGTCT CCTGCCGAAA TCTGGCCGCT351 CCTGAAAGCC TTTTGGCAGG AAAACGGCTT CGACATCAAA TCCGAAGAAC 401CCGCCATCGG ACAAATGGAA ACCGAGTGGG CGGAAAACCG CGCCAAAATC 451 CCCCAAGACAGCTTGCGCCG CCTCTTCGAC AAAGTCGGCT TGGGCGGCAT 501 CTACTCCACC GGCGAGCGCGACAAATTCAT CGTCCGTATC GAACAGGGCA 551 AAAACGGCGT TTCCGACATC TTCTTCGCCCACAAAGCCAT GAAAGAAGTG 601 TACGGCGGCA AAGACAAAGA CACGACCGTA TGGCAGCCCTCCCCGTCCGA 651 TCCCAACCTC GAAGCCGCTT TCCTGACGCG CTTTATGCAA TATTTGGGCG701 TTGACGGACA GCAGGCGGAA AACGCATCGG CAAAAAAACC TACCCTTCCC 751GCCGCCAACG AAATGGCGCG TATCGAAGGC AAAAGCCTGA TTGTCTTTGG 801 CGACTACGGCAGAAACTGGC GGCGCACCGT GCTCGCCCTC GACCGCATCG 851 GGCTGACCGT CGTCGGTCAAAACACCGAAC GCCACGCCTT CCTGGTTCAA 901 AAAGCCCCGA ACGAAAGCAA TGCAGTTACCGAACAAAAAC CCGGCCTGTT 951 CAAACGCCTG CTGGGCAAAG GCAAAGCGGA GAAACCTGCCGAACAGCCGG 1001 AACTGATTGT CTATGCAGAA CCTGTCGCCA ACGGCTCGCG CATCGTCCTG1051 CTCAACAAAG ACGGCAGCGC ATATGCCGGC AAAGACGCAT CCGCATTATT 1101GGGCAAACTC CATTCCGAAC TGCGTTAAThis corresponds to the amino acid sequence <SEQ ID 1522; ORF 529>:

m529.pep 1 MTHIKPVIAA LALIGLAACS GSKTEQPKLD YQSRSHRLIK LEVPPDLNNP 51DQGNLYRLPA GSGAVRASDL EKRRTPAVQQ PADAEVLKSV KGVRLERDGS 101 QRWLVVDGKSPAEIWPLLKA FWQENGFDIK SEEPAIGQME TEWAENRAKI 151 PQDSLRRLFD KVGLGGIYSTGERDKFIVRI EQGKNGVSDI FFAHKAMKEV 201 YGGKDKDTTV WQPSPSDPNL EAAFLTRFMQYLGVDGQQAE NASAKKPTLP 251 AANEMARIEG KSLIVFGDYG RNWRRTVLAL DRIGLTVVGQNTERHAFLVQ 301 KAPNESNAVT EQKPGLFKRL LGKGKAEKPA EQPELIVYAE PVANGSRIVL351 LNKDGSAYAG KDASALLGKL HSELR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 529 shows 83.5% identity over a 115 aa overlap with a predicted ORF(ORF 529.ng) from N. gonorrhoeae:

g529/m529           10        20        30        40        50        60g529.pep   MTHIKPVIAALALIGLAACSGSKTEQPKLDYQSRSHRLIKLEVPPDLNNPDQGNLYRLPA  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m529  MTHIKPVIAALALIGLAACSGSKTEQPKLDYQSRSHRLIKLEVPPDLNNPDQGNLYRLPA          10        20        30        40        50        60          70        80        90       100       110       120 g529.pep  GSGAVRAGDLEKRRTPAVQQPADAGSIEKRQRRPLRAATAANAWLVVDGKSPAEISAAFX  |||||||:||||||||||||||||  ::: :   |:   ::: |||||||||||| m529  GSGAVRASDLEKRRTPAVQQPADAEVLKSVKGVRLER-DGSQRWLVVDGKSPAEIWPLLK          70        80        90        100       110 m529  AFWQENGFDIKSEEPAIGQMETEWAENRAKIPQDSLRRLFDKVGLGGIYSTGERDKFIVR120       130       140       150       160       170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1523>:

a529.seq 1 ATGACCCATA TCAAACCCGT CATTGCCGCG CTCGCACTCA TCGGGCTTGC 51CGCCTGCTCC GGCAGCAAAA CCGAACAGCC CAAGCTCGAC TACCAAAGCC 101 GGTCGCACCGCCTGATCAAA CTCGAAGTCC CACCTGATTT GAAAAACGCC 151 GACCAAGGCA ACCTCTACCGCCTGCCTGCC GGTTCGGGCG CCGTCCGCGC 201 CAGCGATTTG GAAAAACGCC GCACACCCGCCGTCCAACAG CCTGCCGATG 251 CCGAAGTATT GAAAAGCGTC AAAGGTGTCC GCCTCGAGCGCGACGGCAGC 301 CAACGCTGGC TCGTTGTCGA CGGCAAGTCT CATGCCGAAA TCTGGCCGCT351 CCTGAAAGCC TTTTGGCAGG AAAACGGCTT CGACATCAAA TCCGAAGAAC 401CCGCCATCGG ACAAATGGAA ACCGAGTGGG CGGAAAACCG TGCCAAAATC 451 CCCCAAGACAGCTTGCGCCG CCTATTCGAC ACAGTCGGTT TGGGCGGCAT 501 CTACTCCACC GGCGAGCGCGACAAATTCAT CGTCCGTATC GAACAGGGCA 551 AAAACGGCGT TTCCGACATC TTCTTCGCCCACAAAGCCAT GAAAGAAGTG 601 TACGGCGGCA AAGACAAAGA CACGACCGTA TGGCAGCCCTCCCCGTCCGA 651 TCCCAACCTC GAAGCCGCTT TCCTGACGCG CTTTATGCAA TATTTGGGCG701 TTGACGGACA GCAGGCGGAA AACGCATCGG CAAAAAAACC TACCCTTCCC 751GCCGCCAACG AAATGGCGCG TATCGAAGGC AAAAGCCTGA TTGTCTTTGG 801 CGACTACGGCAGAAACTGGC GGCGCACCGC GCTCGCCCTC GACCGCATCG 851 GGCTGACCGT CGTCGGTCAAAACACCGAAC GCCACGCTTT CCTGGTTCAA 901 AAAGCCCCGA ACGAAAGCAA TGCAGTTACCGAACAAAAAC CCGGCCTGTT 951 CAAACGCCTG CTGGGCAAAG GCAAAGCGGA GAAACCTGCCGAACAGCCGG 1001 AACTGATTGT CTATGCCGAG CCTGTCGCCA ACGGCTCGCG CATCGTCCTG1051 CTCAACAAAG ACGGCAGCGC ATATGCCGGC AAAGACGCAT CCGCATTATT 1101GGGCAAACTC CATTCCGAAC TGCGTTAAThis corresponds to the amino acid sequence <SEQ ID 1524; ORF 529.a>:

a529.pep 1 MTHIKPVIAA LALIGLAACS GSKTEQPKLD YQSRSHRLIK LEVPPDLNNP 51DQGNLYRLPA GSGAVRASDL EKRRTPAVQQ PADAEVLKSV KGVRLERDGS 101 QRWLVVDGKSHAEIWPLLKA FWQENGFDIK SEEPAIGQME TEWAENRAKI 151 PQDSLRRLFD TVGLGGIYSTGERDKFIVRI EQGKNGVSDI FFAHKAMKEV 201 YGGKDKDTTV WQPSPSDPNL EAAFLTRFMQYLGVDGQQAE NASAKKPTLP 251 AANEMARIEG KSLIVFGDYG RNWRRTALAL DRIGLTVVGQNTERHAFLVQ 301 KAPNESNAVT EQKPGLFKRL LGKGKAEKPA EQPELIVYAE PVANGSRIVL351 LNKDGSAYAG KDASALLGKL HSELR* m529/a529 99.2% identity in 375 aaoverlap         10        20        30        40        50        60m529.pep MTHIKPVIAALALIGLAACSGSKTEQPKLDYQSRSHRLIKLEVPPDLNNPDQGNLYRLPA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a529MTHIKPVIAALALIGLAACSGSKTEQPKLDYQSRSHRLIKLEVPPDLNNPDQGNLYRLPA        10        20        30        40        50        60        70        80        90       100       110       120 m529.pepGSGAVRASDLEKRRTPAVQQPADAEVLKSVKGVRLERDGSQRWLVVDGKSPAEIWPLLKA|||||||||||||||||||||||||||||||||||||||||||||||||| ||||||||| a529GSGAVRASDLEKRRTPAVQQPADAEVLKSVKGVRLERDGSQRWLVVDGKSHAEIWPLLKA        70        80        90       100       110       120       130       140       150       160       170       180 m529.pepFWQENGFDIKSEEPAIGQMETEWAENRAKIPQDSLRRLFDKVGLGGIYSTGERDKFIVRI|||||||||||||||||||||||||||||||||||||||| ||||||||||||||||||| a529FWQENGFDIKSEEPAIGQMETEWAENRAKIPQDSLRRLFDTVGLGGIYSTGERDKFIVRI       130       140       150       160       170       180       190       200       210       220       230       240 m529.pepEQGKNGVSDIFFAHKAMKEVYGGKDKDTTVWQPSPSDPNLEAAFLTRFMQYLGVDGQQAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a529EQGKNGVSDIFFAHKAMKEVYGGKDKDTTVWQPSPSDPNLEAAFLTRFMQYLGVDGQQAE       190       200       210       220       230       240       250       260       270       280       290       300 m529.pepNASAKKPTLPAANEMARIEGKSLIVFGDYGRNWRRTVLALDRIGLTVVGQNTERHAFLVQ||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||| a529NASAKKPTLPAANEMARIEGKSLIVFGDYGRNWRRTALALDRIGLTVVGQNTERHAFLVQ       250       260       270       280       290       300       310       320       330       340       350       360 m529.pepKAPNESNAVTEQKPGLFKRLLGKGKAEKPAEQPELIVYAEPVANGSRIVLLNKDGSAYAG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a529KAPNESNAVTEQKPGLFKRLLGKGKAEKPAEQPELIVYAEPVANGSRIVLLNKDGSAYAG       310       320       330       340       350       360        370m529.pep KDASALLGKLHSELRX |||||||||||||||| a529 KDASALLGKLHSELRX       370The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1525>:

g530.seq 1 atgagtgcga gcgcggcaat gacgggtttg atatgggtca tcgtgtcatc 51ctgtgtgatg gatattaaag tgtttgtcat gttatgccgt ccgaacggtt 101 cagacggcatggctatattt aaagttgtcc tgaggctttc agggcggcgc 151 ggacttttgc ctgtccgccttccgtcagcg gaacgagcgg caggcgcacg 201 tgcggtccgc atccgcccaa ggcggataccgcccatttcg gtgcggcggg 251 actgggttcg cagaacatgg tgtcgtaaat cggaatcagccggtcgttgaThis corresponds to the amino acid sequence <SEQ ID 1526; ORF 530.ng>:

g530.pep 1 MSASAAMTGL IWVIVSSCVM DIKVFVMLCR PNGSDGMAIF KVVLRLSGRR 51GLLPVRLPSA ERAAGARAVR IRPRRIPPIS VRRDWVRRTW CRKSESAGR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1527>:

m530.seq 1 wTGAGTGCGA GCGCGGCAAT GACGGGTyTG ATATGGGTCA TCGTGTCATC 51sTGTGTGATG GATATTAAAG TGTyTGTTGC GwTATGCCGT CCGAACGGTT 101 CGGACGGCATGGmTATATTT AAAGTTGTCC TGAGGCTTTC AGGGCGGCGC 151 GGACTkTTGC wTGTCCGTTTyCCGTCAGCG GAACGAGCGG CAGGCGGACG 201 TGCGGTTCGC ATCTGCCCAg GGCGGATACCGCCCATTTCG GTGCGGCGGG 251 GCTGGGTTCG CAGAACATGG TGTCGTAAAT CGGAATCAGTCGGTCGTTGAThis corresponds to the amino acid sequence <SEQ ID 1528; ORF 530>:

m530.pep 1 XSASAAMTGL IWVIVSSCVM DIKVXVAXCR PNGSDGMXIF KVVLRLSGRR 51GLLXVRFPSA ERAAGGRAVR ICPGRIPPIS VRRGWVRRTW CRKSESVGR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 530 shows 88.8% identity over a 98 aa overlap with a predicted ORF(ORF 530.ng) from N. gonorrhoeae:

m530/g530 m530.pepXSASAAMTGLIWVIVSSCVMDIKVXVAXCRPNGSDGMXIFKVVLRLSGRRGLLXVRFPSA 60 ||||||||||||||||||||||| |  ||||||||| ||||||||||||||| ||:||| g530MSASAAMTGLIWVIVSSCVMDIKVFVMLCRPNGSDGMAIFKVVLRLSGRRGLLPVRLPSA 60        10        20        30        40        50        60 m530.pepERAAGGRAVRICPGRIPPISVRRGWVRRTWCRKSESVGR 99|||||:||||| | ||||||||| ||||||||||||:|| g530ERAAGARAVRIRPRRIPPISVRRDWVRRTWCRKSESAGR 99The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1529>:

a530.seq 1 ATGAGTGCGA GCGCGGCAAT GACGGGTTTG ATATGGGTCA TCGTGTCATC 51CTGTGTGATG GATATTAAAG TGTTTGTTGC GTTATGCCGT CCGAACGGTT 101 CGGACGGCATGGCTATATTT AAAGTTGTCC TGAGGCTTTC AGGGCGGCGC 151 GGACTTTTGC CTGTCCGCCTTCCGTCAGCG GAACGAGCGG CAGGCGGACG 201 TGCGGTTCGC ATCTGCCCAG GGCGGATACCGCCCATTTCG GTGCGGCGGG 251 GCTGGGTTCG CAGAACATGG TGTCGTAAAT CGGAATCAGCCGGTCGTTGAThis corresponds to the amino acid sequence <SEQ ID 1530; ORF 530.a>:

a530.pep 1 MSASAAMTGL IWVIVSSCVM DIKVFVALCR PNGSDGMAIF KVVLRLSGRR 51GLLPVRLPSA ERAAGGRAVR ICPGRIPPIS VRRGWVRRTW CRKSESAGR* m530/a530 93.9%identity in 98 aa overlap        10        20        30        40        50        60 m530.pepXSASAAMTGLIWVIVSSCVMDIKVXVAXCRPNGSDGMXIFKVVLRLSGRRGLLXVRFPSA ||||||||||||||||||||||| || ||||||||| ||||||||||||||| ||:||| a530MSASAAMTGLIWVIVSSCVMDIKVFVALCRPNGSDGMAIFKVVLRLSGRRGLLPVRLPSA        10        20        30        40        50        60        70        80        90       100 m530.pepERAAGGRAVRICPGRIPPISVRRGWVRRTWCRKSESVGRX||||||||||||||||||||||||||||||||||||:||| a530ERAAGGRAVRICPGRIPPISVRRGWVRRTWCRKSESAGRX        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1531>:

g531.seq 1 ATGACCGCCC TACTCGTCAT CCTCGCCCTC GCCCTGATAG CCGTCGGCAC 51GGCAGGCATC GTCTATCCCG CCCTGCCCGG CTTGGCATTG ATGTTTGCCG 101 GAACATGGCTGCTTGCCTAT GCCGGCGGCT ATCAAATCTA CGGCGCAGGC 151 ATCTTGTGGA CGGTCGGACTCATCAGCCTT GGCGGCATAC TGGCGGACTA 201 TATGGCAGGC ATGTTGGGGG TAAAATACACTGGGGCAGGC AAACTCGCCG 251 TCCGAGGTGC ATTGGCCGGC AGCATCATCG GCATATTTTTCTCCCTTCCC 301 GGACTAATAC TCGGCCCCTT TATCGGCGCG GCGGCAGGCG AACTGATCGA351 TCGGCGCAAT ATGCTTCAGG CAGGTAAAGC GGGCTTGGGT ACGCTGTTGG 401GGCTTGTCGT CGGCACGGCG TTCAAAATCG GCTGCGCCGT ATCCATCTTG 451 TTTATCCTGTTGGTGAAATA CATCGCATAC CTGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 1532; ORF 531.ng>:

g531.pep 1 MTALLVILAL ALIAVGTAGI VYPALPGLAL MFAGTWLLAY AGGYQIYGAG 51ILWTVGLISL GGILADYMAG MLGVKYTGAG KLAVRGALAG SIIGIFFSLP 101 GLILGPFIGAAAGELIDRRN MLQAGKAGLG TLLGLVVGTA FKIGCAVSIL 151 FILLVKYIAY LFThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1533>:

m531.seq 1 ATGACCGTAC TGACCGTCAT CCTCGCCCTC GCCCTGATAG CCGTCGGCAC 51GGCGGGCATC GTTTaCCCCG CCCTGCCCGG ATTGGCATTG ATGTTTGCCG 101 GAACATGGCTGCTTGCCTAT GCCGGCGGCT ACCAAATCTA CGGCGCGGGC 151 GTTTTGTGGA CGGTCGGACTCATCAGCCTT GCCGGCATAC TGGCGGACTA 201 TGTGGCAGGC ATATGGGGGA CAAAATATACCGGAGCGGGC AAGCTCGCCG 251 TTCGCGGCGC ATTGGCCGGC AGCATCATCG GCATATTTTTCTCCCTTCCC 301 GGACTAATAC TCGGTCCCTT TATCGGCGCG GCGGCAGGCG AACTGATCGA351 ACGGCGCAAT ATGCTTCAGG CAGGTAAAGC GGGCTTGGGT ACGCTGTTGG 401GGCTTGTCGT CGGCACGGCG TTCAAAATCG GCTGCGCnGT ATCCATCTTG 451 TTTATCCTGTTGGTGAaATA CATCGCCTAC CTGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 1534; ORF 531>:

m531.pep 1 MTVLTVILAL ALIAVGTAGI VYPALPGLAL MFAGTWLLAY AGGYQIYGAG 51VLWTVGLISL AGILADYVAG IWGTKYTGAG KLAVRGALAG SIIGIFFSLP 101 GLILGPFIGAAAGELIERRN MLQAGKAGLG TLLGLVVGTA FKIGCAVSIL 151 FILLVKYIAY LF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 531 shows 94.4% identity over a 162 aa overlap with a predicted ORF(ORF 531.ng) from N. gonorrhoeae:

m531/g531         10        20        30        40        50        60m531.pep MTVLTVILALALIAVGTAGIVYPALPGLALMFAGTWLLAYAGGYQIYGAGVLWTVGLISL||:| |||||||||||||||||||||||||||||||||||||||||||||:||||||||| g531MTALLVILALALIAVGTAGIVYPALPGLALMFAGTWLLAYAGGYQIYGAGILWTVGLISL        10        20        30        40        50        60        70        80        90       100       110       120 m531.pepAGILADYVAGIWGTKYTGAGKLAVRGALAGSIIGIFFSLPGLILGPFIGAAAGELIERRN:||||||:||: |:||||||||||||||||||||||||||||||||||||||||||:||| g531GGILADYMAGMLGVKYTGAGKLAVRGALAGSIIGIFFSLPGLILGPFIGAAAGELIDRRN        70        80        90       100       110       120       130       140       150       160 m531.pepMLQAGKAGLGTLLGLVVGTAFKIGCAVSILFILLVKYIAYLF|||||||||||||||||||||||||||||||||||||||||| g531MLQAGKAGLGILLGLVVGTAFKIGCAVSILFILLVKYIAYLF       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1535>:

a531.seq 1 ATGACCGCCT TGCTCGTCAT CCTCGCCCTC GCCCTGATAG CCGCCGGTAC 51GGCGGGCATC GTTTACCCCG CCCTGCCCGG ATTGGCATTG ATGTTTGCCG 101 GAACCTGGCTGCTCGCCTAC TCCGGCGGCT ACCAAATCTA CGGCGCGGGC 151 GTTTTGTGGA CGGTCGGACTCATCAGCCTT GCCGGCATAC TGGCGGACTA 201 TGTGGCAGGC ATATGGGGGA CAAAATATACCGGAGCGGGC AAGCTCGCCG 251 TTCGCGGCGC ATTGGCCGGC AGCATCATCG GCATATTTTTCTCCCTTCCC 301 GGACTAATAC TCGGTCCCTT TATCGGCGCG GCGGCAGGCG AACTGATCGA351 ACGGCGCAAT ATGCTTCAGG CAGGTAAAGC GGGCTTGGGT ACGCTGTTGG 401GGCTTATCGT CGGTACGGCG TTCAAAATCG GCTGCGCCGT ATCCATCTTG 451 TTTATCCTGTTGGTGAAATA CATCGCCTAC CTGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 1536; ORF 531.a>:

a531.pep 1 MTALLVILAL ALIAAGTAGI VYPALPGLAL MFAGTWLLAY SGGYQIYGAG 51VLWTVGLISL AGILADYVAG IWGTKYTGAG KLAVRGALAG SIIGIFFSLP 101 GLILGPFIGAAAGELIERRN MLQAGKAGLG TLLGLIVGTA FKIGCAVSIL 151 FILLVKYIAY LF* m531/a53196.9% identity in 162 aa overlap        10        20        30        40        50        60 m531.pepMTVLTVILALALIAVGTAGIVYPALPGLALMFAGTWLLAYAGGYQIYGAGVLWTVGLISL||:| |||||||||:|||||||||||||||||||||||||:||||||||||||||||||| a531MTALLVILALALIAAGTAGIVYPALPGLALMFAGTWLLAYSGGYQIYGAGVLWTVGLISL        10        20        30        40        50        60        70        80        90       100       110       120 m531.pepAGILADYVAGIWGTKYTGAGKLAVRGALAGSIIGIFFSLPGLILGPFIGAAAGELIERRN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a531AGILADYVAGIWGTKYTGAGKLAVRGALAGSIIGIFFSLPGLILGPFIGAAAGELIERRN        70        80        90       100       110       120       130       140       150       160 m531.pepMLQAGKAGLGTLLGLVVGTAFKIGCAVSILFILLVKYIAYLFX|||||||||||||||:||||||||||||||||||||||||||| a531MLQAGKAGLGTLLGLIVGTAFKIGCAVSILFILLVKYIAYLFX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1537>:

g532.seq (partial) 1 atggctgaaa caatgaaaaa acaggcggat tcgcctgatttggtgtacgg 51 tttggaagac aggccgccgt tcggtaatgc gctcttgagc gcggttaccc 101atcttttggc gattttcgtg ccgatgatta cgcccgcgct gattgtgggc 151 ggcgcgctggaattgccggt ggagatgacg gcgtatctgg tgtcgatggc 201 gatggttgcg tcgggtgtcggcacttattt gcaggtcaac cgcttcgggt 251 cggtcggctc ggggatgctg tccatccagcgttaccgtca tgattgcgct 301 cggcgcgggg atgaaagagg gcggtttgag ...This corresponds to the amino acid sequence <SEQ ID 1538; ORF 532.ng>:

g532.pep (partial) 1 MAETMKKQAD SPDLVYGLED RPPFGNALLSAVTHLLAIFV PMITPALIVG 51 GALELPVEMT AYLVSMAMVA SGVGTYLQVN RFGSVGSGMLSIQRYRHDCA 101 RRGDERGRFE ...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1539>:

m532.seq 1 ATGAGCGGTC AGTTGGGCAA AGGTGCGGAT GCGCCTGATT TGGTGTACGG 51TTTGGAAGAC AGGCCGCCGT TCGGTAATGC GCTCTTGAGC GCGGTTACCC 101 ATCTTTTGGCGATTTTTGTG CCGATGATTA CGCCCGCGCT GATTGTGGGC 151 GGCGCGCTGG AATTGCCGGTGGAGATGACG GCGTATCTCG TGTCGATGGC 201 GATGGTTGCG TCGGGTGTCG GCACTTATTTGCAGGTCAAC CGCTTCGGGC 251 CGGTCGGTTC GGGGATGCTG TCCATCCAGT CGGTGAATTTTTCGTTCGTT 301 ACCGTGATGA TTGCGCTGGG CGCGGGGATG AAAGAGGGCG GTTTGACTAA351 GGATGCGATG ATTTCGACGC TCTTGGGCGT ATCGTTTGTC GGCGCGTTTT 401TGGTGTGTTT CTCGGCGTGG CTTCTGCCGT ATTTGAAAAA AGTGATTACG 451 CCGACGGTCAGCGGCGTGGT CGTGATGCTC ATTGGTTTGA GTTTGGTACA 501 CGTCGGCATT ACCGATTTCGGCGGCGGCTT CGGCGCGAAG GCGGACGGCA 551 CGTTCGGCTC GATGGAAAAC TTGGGGCTGGCATCGCTGGT GTTGCTGATT 601 GTGTTGGTGT TCAACTGCAT GAAAAACCCG CTGTTGCGCATGAGCGGCAT 651 TGCGGTCGGG CTGATTGCCG GCTATATCGT CGCGCTGTTT TTGGGCAAGG701 TGGATTTTTC CGCGCTGCAA AACCTGCCGC TGGTTACGCT GCCCGTACCG 751TTTAAATACG GTTTTGCTTT CGACTGGCAC GCGTTTATTG TGGCGGGCGC 801 GATTTTCTTGTTGAGCGTGT TTGAGGCGGT CGGCGATTTA ACCGCGACGG 851 CAATGGTGTC CGACCAGCCGATTGAAGGCG AGGAATACAC CAAACGCCTG 901 CGCGGCGGCG TGTTGGCTGA CGGCTTGGTGTCGGTGATTG CGACGGCTTT 951 GGGTTCGCTG CCGCTGACGA CGTTTGCGCA AAACAACGGCGTGATTCAGA 1001 TGACCGGCGT GGCTTCGCGC CATGTGGGCA AATATATTGC CGTGATTTTG1051 GTGCTGTTGG GTCTGTTCCC CGTTGTCGGT CGCGCGTTTA CGACGATTCC 1101GAGTCCGGTG TTGGGCGGCG CGATGGTTTT GATGTTCGGC TTAATTGCGA 1151 TTGCGGGCGTGCGGATTTTG GTCAGTCACG GCATCCGCAG GCGCGAAGCG 1201 GTGATTGCGG CAACGTCGGTCGGTTTGGGC TTGGGTGTCG CGTTTGAGCC 1251 GGAAGTGTTT AAAAACCTGC CCGTCTTGTTCCAAAACTCT ATTTCCGCCG 1301 GCGGCATTAC GGCAGTCTTG CTGAATTTGG TCTTGCCCGAAGATAAAACC 1351 GAGGCGGCGG TCAAGTTTGA TACCGACCAC TTGGAACACT GAThis corresponds to the amino acid sequence <SEQ ID 1540; ORF 532>:

m532.pep 1 MSGQLGKGAD APDLVYGLED RPPFGNALLS AVTHLLAIFV PMITPALIVG 51GALELPVEMT AYLVSMAMVA SGVGTYLQVN RFGPVGSGML SIQSVNFSFV 101 TVMIALGAGMKEGGLTKDAM ISTLLGVSFV GAFLVCFSAW LLPYLKKVIT 151 PTVSGVVVML IGLSLVHVGITDFGGGFGAK ADGTFGSMEN LGLASLVLLI 201 VLVFNCMKNPLLRMSGIAVG LIAGYIVALF LGKVDFSALQ NLPLVTLPVP 251FKYGFAFDWH AFIVAGAIFL LSVFEAVGDL TATAMVSDQP IEGEEYTKRL 301RGGVLADGLV SVIATALGSL PLTTFAQNNG VIQMTGVASR HVGKYIAVIL 351 VLLGLFPVVGRAFTTIPSPV LGGAMVLMFG LIAIAGVRIL VSHGIRRREA 401 VIAATSVGLG LGVAFEPEVFKNLPVLFQNS ISAGGITAVL LNLVLPEDKT 451 EAAVKFDTDH LEH*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF532 shows 91.4% identity over a 93 aa overlap with a predicted ORF(ORF 532.ng) from N. gonorrhoeae:

g532/m532         10        20        30        40        50        60g532.pep MAETMKKQADSPDLVYGLEDRPPFGNALLSAVTHLLAIFVPMITPALIVGGALELPVEMT|:  : | ||:||||||||||||||||||||||||||||||||||||||||||||||||| m532MSGQLGKGADAPDLVYGLEDRPPFGNALLSAVTHLLAIFVPMITPALIVGGALELPVEMT        10        20        30        40        50        60        70        80        90       100       110 g532.pepAYLVSMAMVASGVGTYLQVNRFGSVGSGMLSIQRYRHDCARRGDERGRFEX||||||||||||||||||||||| ||||||||| m532AYLVSMAMVASGVGTYLQVNRFGPVGSGMLSIQSVNFSFVTVMIALGAGMKEGGLTKDAM        70        80        90       100       110       120The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1541>:

a532.seq 1 ATGAGCGGTC AGTTGGGCAA AGGTGCGGAT GCGCCTGATT TGGTGTACGG 51TTTGGAGGAT AGGCCGCCGT TCGGTAATGC GCTCTTGAGC GCGGTTACCC 101 ATCTTTTGGCGATTTTTGTG CCGATGATTA CGCCCGCGCT GATTGTGGGC 151 GGCGCGCTGG AATTGCCGGTGGAGATGACG GCGTATCTCG TGTCGATGGC 201 GATGGTTGCG TCGGGTGTCG GCACTTATTTGCAGGTCAAC CGCTTCGGGC 251 CGGTCGGTTC GGGGATGCTG TCCATCCAGT CGGTGAATTTCTCGTTCGTT 301 ACCGTCATGA TTGCGCTCGG CGCGGGGATG AAAGAGGGCG GTTTGACTAA351 GGATGCGATG ATTTCGACGC TCTTGGGCGT ATCGTTTGTC GGCGCGTTTT 401TGGTGTGTTT TTCGGCGTGG CTTCTGCCGT ATTTGAAAAA AGTGATTACG 451 CCGACGGTCAGCGGTGTGGT GGTGATGCTG ATCGGCTTGA GTTTGGTACA 501 CGTCGGTATT ACCGATTTCGGCGGCGGCTT CGGCGCAAAG GCGGACGGCA 551 CGTTCGGCTC GATGGAAAAC TTGGGGCTGGCATCGCTGGT GCTGCTGATT 601 GTGCTGGTGT TCAATTGCAT GAAAAACCCG CTGCTGCGGATGAGCGGCAT 651 TGCGGTCGGT CTGATTGCCG GCTATATCGT CGCGCTGTTT TTGGGCAAGG701 TGGATTTTTC GGCACTGCAA AACCTGCCGC TGGTTACGCT GCCCGTACCG 751TTTAAATATG GTTTTGCTTT TGACTGGCAC GCATTTATTG TGGCGGGTGC 801 GATTTTCTTGTTGAGCGTGT TTGAGGCGGT CGGCGATTTG ACGGCGACGG 851 CAATGGTGTC CGACCAGCCGATTGAAGGCG AGGAATACAC CAAACGCTTG 901 CGCGGCGGCG TGTTGGCGGA CGGCTTGGTGTCGGTGATTG CGACGGCTTT 951 GGGTTCGCTG CCGCTGACGA CGTTTGCACA AAACAACGGCGTGATTCAGA 1001 TGACCGGCGT GGCTTCGCGC CATGTGGGCA AATATATTGC CGTGATTTTG1051 GTGCTGTTGG GTCTGTTCCC CGTTGTCGGA CGCGCGTTTA CGACGATTCC 1101GAGTCCGGTG TTGGGCGGCG CGATGGTTTT GATGTTCGGC TTGATTGCGA 1151 TTGCGGGCGTGCGGATTTTG GTCAGCCACG GCATCCGCAG GCGCGAAGCG 1201 GTAATTGCGG CAACGTCGGTCGGTTTGGGC TTGGGTGTCG CGTTTGAGCC 1251 GGAAGTGTTT AAAAACCTGC CCGTCTTGTTCCAAAACTCT ATTTCCGCCG 1301 GCGGCATTAC GGCAGTCTTG CTGAATTTGG TCTTGCCCGAAGATAAAACC 1351 GAGGCGGCGG TCAAGTTTGA TACCGACCAC TTGGAACACT GAThis corresponds to the amino acid sequence <SEQ ID 1542; ORF 532.a>:

a532.pep 1 MSGQLGKGAD APDLVYGLED RPPFGNALLS AVTHLLAIFV PMITPALIVG 51GALELPVEMT AYLVSMAMVA SGVGTYLQVN RFGPVGSGML SIQSVNFSFV 101 TVMIALGAGMKEGGLTKDAM ISTLLGVSFV GAFLVCFSAW LLPYLKKVIT 151PTVSGVVVML IGLSLVHVGI TDFGGGFGAK ADGTFGSMEN LGLASLVLLI 201 VLVFNCMKNPLLRMSGIAVG LIAGYIVALF LGKVDFSALQ NLPLVTLPVP 251 FKYGFAFDWHAFIVAGAIFL LSVFEAVGDL TATAMVSDQP IEGEEYTKRL 301RGGVLADGLV SVIATALGSL PLTTFAQNNG VIQMTGVASR HVGKYIAVIL 351VLLGLFPVVG RAFTTIPSPV LGGAMVLMFG LIAIAGVRIL VSHGIRRREA 401VIAATSVGLG LGVAFEPEVF KNLPVLFQNS ISAGGITAVL LNLVLPEDKT 451 EAAVKFDTDHLEH* m532/a532 100.0% identity in 463 aa overlap        10        20        30        40        50        60 m532.pepMSGQLGKGADAPDLVYGLEDRPPFGNALLSAVTHLLAIFVPMITPALIVGGALELPVEMT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a532MSGQLGKGADAPDLVYGLEDRPPFGNALLSAVTHLLAIFVPMITPALIVGGALELPVEMT        10        20        30        40        50        60        70        80        90       100       110       120 m532.pepAYLVSMAMVASGVGTYLQVNRFGPVGSGMLSIQSVNFSFVTVMIALGAGMKEGGLTKDAM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a532AYLVSMAMVASGVGTYLQVNRFGPVGSGMLSIQSVNFSFVTVMIALGAGMKEGGLTKDAM        70        80        90       100       110       120       130       140       150       160       170       180 m532.pepISTLLGVSFVGAFLVCFSAWLLPYLKKVITPTVSGVVVMLIGLSLVHVGITDFGGGFGAK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a532ISTLLGVSFVGAFLVCFSAWLLPYLKKVITPTVSGVVVMLIGLSLVHVGILDFGGGFGAK       130       140       150       160       170       180       190       200       210       220       230       240 m532.pepADGTFGSMENLGLASLVLLIVLVFNCMKNPLLRMSGIAVGLIAGYIVALFLGKVDFSALQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a532ADGTFGSMENLGLASLVLLIVLVFNCMKNPLLRMSGIAVGLIAGYIVALFLGKVDFSALQ       190       200       210       220       230       240       250       260       270       280       290       300 m532.pepNLPLVTLPVPFKYGFAFDWHAFIVAGAIFLLSVFEAVGDLTATAMVSDQPIEGEEYTKRL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a532NLPLVTLPVPFKYGFAFDWHAFIVAGAIFLLSVFEAVGDLTATAMVSDQPIEGEEYTKRL       250       260       270       280       290       300       310       320       330       340       350       360 m532.pepRGGVLADGLVSVIATALGSLPLTTFAQNNGVIQMTGVASRHVGKYIAVILVLLGLFPVVG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a532RGGVLADGLVSVIATALGSLPLTTFAQNNGVIQMTGVASRHVGKYIAVILVLLGLFPVVG       310       320       330       340       350       360       370       380       390       400       410       420 m532.pepRAFTTIPSPVLGGAMVLMFGLIAIAGVRILVSHGIRRREAVIAATSVGLGLGVAFEPEVF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a532RAFTTIPSPVLGGAMVLMFGLIAIAGVRILVSHGIRRREAVIAATSVGLGLGVAFEPEVF       370       380       390       400       410       420       430       440       450       460 m532.pepKNLPVLFQNSISAGGITAVLLNLVLPEDKTEAAVKFDTDHLEHX|||||||||||||||||||||||||||||||||||||||||||| a532KNLPVLFQNSISAGGITAVLLNLVLPEDKTEAAVKFDTDHLEHX       430       440       450       460The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1543>:

g535.seq 1 atgccctttc ccgttttcag acaantattt gcttngtcct tgctacggtt 51ttttgccgta ggtcggattc tcgaatccga catttccaac agcggttttt 101 cggaaacgataaacgcgtca aatgtttttt ttgtcggata cgaatatccg 151 gcctgcattt caaatttacatcgcttccaa tttcgcaaac ttggtatcca 201 gttctttcac gccctgtttg ccgaagttgatggtcagtcg ggcggattcg 251 cctttgtctg cggcatcgat aatcacgccg gtgccgaatttggcgtgacg 301 gacgttttgt ccgatgcgga agcctgcgta ggtttgcggc tgtttgaagt351 catcgatgat tttgtcccgt tgtacggtgg tttggcgcgt gttgccgtag 401ctgtcgaagg cgggtttttt gacggacagg tagtgcaata cttctggcgg 451 gatttcttcgacgaagcggg atgcgatgcc gaattgggtt tgtccgtgca 501 gcatgcgttg ctgtgccatggtgatgtaga ggcgtttgcg ggcgcgggtg 551 atggcgacgt acatgaggcg gcgttcttcttcgaggccgc cgcgctcggc 601 aaggctcatt tcgctgggga aacgcccctc ttccataccggtgaggaaga 651 cggcgttgaa ttccaagcct ttggcggcgt ggacggtcat cagttggacg701 gctttttcgc ctgcccctgc ttggttttcg ccggattcga gggcggcgtt 751gctcaagaag gcgaggatgg ggaaggcggg atcgtctgaThis corresponds to the amino acid sequence <SEQ ID 1544; ORF 535.ng>:

g535.pep 1 MPFPVFRQXF AXSLLRFFAV GRILESDISN SGFSETINAS NVFFVGYEYP 51ACISNLHRFQ FRKLGIQFFH ALFAEVDGQS GGFAFVCGID NHAGAEFGVT 101 DVLSDAEACVGLRLFEVIDD FVPLYGGLAR VAVAVEGGFF DGQVVQYFWR 151 DFFDEAGCDA ELGLSVQHALLCHGDVEAFA GAGDGDVHEA AFFFEAAALG 201 KAHFAGETPL FHTGEEDGVE FQAFGGVDGHQLDGFFACPC LVFAGFEGGV 251 AQEGEDGEGG IV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1545>:

m535.seq 1 aTGCCCTTtC CCGTTTTCAG ACGGCCTTTT GCTTTGTCCT TACTtACGTT 51TTTTGCCGTA AGTCAGATTC TTGTATCCGA CATTTCCAAC AGCGGTGTTT 101 CGGAAACAATAGACGCGTCA AATGTTTTTG TCGGATACGA ATATCCGACC 151 TACATTTCAA ATTTACATCTCTTCCAATTT CGCAAACTTG GTGTCCAACT 201 CTTTCACGCC CTGTTTGCCG AAATTGATGGTCAGTCGGGC GGATTCGCCT 251 TTATCTGCGG CATCGATAAT CACGCCGGTG CCGAATTTGGCGTGGCGGAC 301 GTTTTGTCCG ATACGGAAAC CTGCGTAGGT TTGGGGCTGT TTGTAGTCGT351 CGATGATTTT ATCTTTGGAT GCGGCGGTTT GGCGCGTGTT GCCGTAACTG 401TCGTAGGCAG GCTTTTTGAC GGACAGGTAG TGCAATACTT CGGGTGGGAT 451 CTCTTCGACGAAGCGGGAGA CGATGCCGAA TTGGGTTTGT CCGTGCAGCA 501 TGCGTTGTTG CGCCATGGTGATGTAGAGGC GTTTGCGGGC GCGGGTGATG 551 GCGACGTACA TGAGGCGGCG TTCTTCTTCGAGGCCGCCGC GTTCGGCAAG 601 GCTCATTTCG CTGGGGAAGC GGCCTTCTTC CATGCCGGTGAGGAAGACGG 651 CGTTAAATTC CAAGCCTTTG GCGGCGTGGA CGGTCATGAG TTGGACGGCC701 TTTTCGCCTG CGCCTGCCTG GTTTTCACCG GATTCGAGGG CGGCATTGCT 751TAGGAAGGCG AGAATGGGGA AGGCGGGGTC GTCTGAThis corresponds to the amino acid sequence <SEQ ID 1546; ORF 535>:

m535.pep 1 MPFPVFRRPF ALSLLTFFAV SQILVSDISN SGVSETIDAS NVFVGYEYPT 51YISNLHLFQF RKLGVQLFHA LFAEIDGQSG GFAFICGIDN HAGAEFGVAD 101 VLSDTETCVGLGLFVVVDDF IFGCGGLARV AVTVVGRLFD GQVVQYFGWD 151 LFDEAGDDAE LGLSVQHALLRHGDVEAFAG AGDGDVHEAA FFFEAAAFGK 201 AHFAGEAAFF HAGEEDGVKF QAFGGVDGHELDGLFACACL VFTGFEGGIA 251 XEGENGEGGV V*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 535 shows 80.9% identity over a 262 aa overlap with a predicted ORF(ORF 535.ng) from N. gonorrhoeae:

m535/g535           10        20        30        40         50       59m535.pep   MPFPVFRRPFALSLLTFFAVSQILVSDISNSGVSETIDASNVF-VGYEYPTYISNLHLFQ  |||||||: || ||| ||||::|| ||||||| ||||:||||| ||||||: ||||| || g535  MPFPVFRQXFAXSLLRFFAVGRILESDISNSGFSETINASNVFFVGYEYPACISNLHRFQ          10        20        30        40        50        60 60        70        80        90       100       110      119 m535.pep  FRKLGVQLFHALFAEIDGQSGGFAFICGIDNHAGAEFGVADVLSDTETCVGLGLFVVVDD  |||||:|:|||||||:|||||||||:|||||||||||||:|||||:|:|||| || |:|| g535  FRKLGIQFFHALFAEVDGQSGGFAFVCGIDNHAGAEFGVTDVLSDAEACVGLRLFEVIDD          70        80        90       100       110       120120       130       140       150       160       170      179 m535.pep  FIFGCGGLARVAVTVVGRLFDGQVVQYFGWDLFDEAGDDAELGLSVQHALLRHGDVEAFA  |:   ||||||||:| | :|||||||||  |:||||| ||||||||||||| |||||||| g535  FVPLYGGLARVAVAVEGGFFDGQVVQYFWRDFFDEAGCDAELGLSVQHALLCHGDVEAFA         130       140       150       160       170       180180       190       200       210       220       230      239 m535.pep  GAGDGDVHEAAFFFEAAAFGKAHFAGEAAFFHAGEEDGVKFQAFGGVDGHELDGLFACAC  ||||||||||||||||||:||||||||: :||:||||||:||||||||||:|||:||| | g535  GAGDGDVHEAAFFFEAAALGKAHFAGETPLFHTGEEDGVEFQAFGGVDGHQLDGFFACPC         190       200       210       220       230       240240       250       260 m535.pep   LVFTGFEGGIAXEGENGEGGVV  |||:|||||:| |||:||||:| g535   LVFAGFEGGVAQEGEDGEGGIV         250       260The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1547>:

a535.seq (partial) 1 TTCAGACGGC CTTTTGCCTT GTCCTTGCTA CAGTTTTTTGCCATAGGTCG 51 GATTCTCGAA TCCGACATTT CCAACAGCGG TTTTTCGGAA ACGATAGACG 101CGTCAAATAT TTTTGTCGGA TACGAGTATC CAGCCTGCAT TTCAAATTTA 151 CATCGCTTCCAATTTCGCAA ACTTGGTGTC CAACTCTTTC ACGCCCTGTT 201 TGCCGAAATT GATGGTCAGTCGGGCGGATT CGCCTTTATC TGCGGCATCG 251 ATAATCACGC CGGTGCCGAA TTTGGCGTGGCGGACGTTTT GTCCGATACG 301 GAAACCTGCG TAGGTTTGGG GCTGTTTGTA GTCGTCGATGATTTTGTCTT 351 TGGGCGCGGC GGTTTGGCGC GTGTTGCCAT AGCGGTCGTA GGCGGGTTTT401 TTGACGGACA GGTAGTGCAA TACTTCGGGC GGGATTTCTT CGACGAAGCG 451GGAGACGATG CCGAATTGGG TTTGTCCGTG CAGCATGCGT TGTTGCGCCA 501 TGGTGATGTAGAGGCGTTTG CGGGCGCGGG TGATGGCGAC GTACATCAGG 551 CGGCGTTCTT CTTCGAGGCCGCCGCGTTCG GCAAGGCTCA TTTCGCTGGG 601 GAAGCGGCCT TCTTCCATGC CGGTGAGGAATACGGCGTTA AATTCCAAGC 651 CTTTGGCGGC GTGCACGGTC ATGAGTTGTA CGGCTTTTTCGCCCGCGCCT 701 GCTTGGTTTT CGCCGGATTC GAGAGCAGCA TTGCTTAGGA AAGCGAGGAT751 GGGGAAGGCG GGGTCGTCTG AThis corresponds to the amino acid sequence <SEQ ID 1548; ORF 535.a>:

a535.pep (partial) 1 FRRPFALSLL QFFAIGRILE SDISNSGFSE TIDASNIFVGYEYPACISNL 51 HRFQFRKLGV QLFHALFAEI DGQSGGFAFI CGIDNHAGAE FGVADVLSDT 101ETCVGLGLFV VVDDFVFGRG GLARVAIAVV GGFFDGQVVQ YFGRDFFDEA 151 GDDAELGLSVQHALLRHGDV EAFAGAGDGD VHQAAFFFEA AAFGKAHFAG 201 EAAFFHAGEE YGVKFQAFGGVHGHELYGFF ARACLVFAGF ESSIA*ESED 251 GEGGVV* m535/a535 88.7% identity in256 aa overlap        10        20        30        40        50        60 m535.pepMPFPVFRRPFALSLLTFFAVSQILVSDISNSGVSETIDASNVFVGYEYPTYISNLHLFQF     |||||||||| |||:::|| ||||||| ||||||||:|||||||: ||||| ||| a535     FRRPFALSLLQFFAIGRILESDISNSGFSETIDASNIFVGYEYPACISNLHRFQF             10        20        30        40        50        70        80        90       100       110       120 m535.pepRKLGVQLFHALFAEIDGQSGGFAFICGIDNHAGAEFGVADVLSDTETCVGLGLFVVVDDF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a535RKLGVQLFHALFAEIDGQSGGFAFICGIDNHAGAEFGVADVLSDTETCVGLGLFVVVDDF   60        70        80        90       100       110       130       140       150       160       170       180 m535.pepIFGCGGLARVAVTVVGRLFDGQVVQYFGWDLFDEAGDDAELGLSVQHALLRHGDVEAFAG:|| |||||||::||| :|||||||||| |:||||||||||||||||||||||||||||| a535VFGRGGLARVAIAVVGGFFDGQVVQYFGRDFFDEAGDDAELGLSVQHALLRHGDVEAFAG  120       130       140       150       160       170       190       200       210       220       230       240 m535.pepAGDGDVHEAAFFFEAAAFGKAHFAGEAAFFHAGEEDGVKFQAFGGVDGHELDGLFACACL|||||||:||||||||||||||||||||||||||| |||||||||| |||| |:|| ||| a535AGDGDVHQAAFFFEAAAFGKAHFAGEAAFFHAGEEYGVKFQAFGGVHGHELYGFFARACL  180       190       200       210       220       230       250       260 m535.pep VFTGFEGGIAXEGENGEGGVVX||:|||::||||:|:||||||| a535 VFAGFESSIAXESEDGEGGVVX   240       250The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1549>:

g537.seq 1 atgaaatccc tttttatttg gctgcttcta ttgggctcgg cggcaggcgt 51tttctaccat acccaaaacc aatccctgcc cgcgggcgaa cttgtctatc 101 cgtccgcaccgcaaatcagg gacggcggcg atgcgctgca ctacctcaac 151 cgcatccgca cacaaatcggtttgcacgcg ctggcacacg cgccggtttt 201 ggaaaattcc gcccgcaggc acgcacgctatctcacgctc aatcccgaag 251 acggacacgg cgaacaccat cccgacaatc cgcactacaccgcacaaaag 301 ctgaccgaac gcacacgcct tgccgggtat ctctacaacg gcgtgcatga351 aaacatcagc acggaagagg aagccgccga atcgtccgac agcgacatcc 401gcacgcagca acgccaagtg gacgctttga tgagcgcaat ctaccaccgc 451 ctttcgctgcttgaccgcca taccgacgaa gcaggtgcgg catttgtgcg 501 cgaaaacggc aaaaccgtcctcgtattcaa tcagggcaac ggcagcttcg 551 agcgcgcctg tgcaaaagga aggcggcagccggaagcagg acggaaatat 601 taccgcaacg cttgccacaa cggtgcggcc gtttatgctgacgaagccat 651 gcccgtaacg gaattgcttt ataccgccta tccggttggc ggcggcgcgc701 tgccttattt ttacggggaa cgtcccgacc ccgtgccgga atatgaaatc 751acaggcaatc ctgccagcat tgatttttcc gaggcggcag gcaaaattgc 801 gatgaaaagtttcaagctgt atcagggtaa aaacgaaatc cgccccgtca 851 gggttttaac cgccggcaacgaccctaacg gcaggctgac cgcgcaccaa 901 ttcgcccttt tcccgctcaa acctttggaatacggcacgc tttatacggc 951 ggtattcgac tatgtccgca acggacggca cgcgcaggcgaaatggcagt 1001 ttagaacccg aaaacccgat tacccttatt ttgaggtaaa cggcggcgag1051 acacttgcgg ttagaaaagg cgaaaaatat ttcatccact ggcgcggacg 1101ctggtgtctg gaagcgtgta cccgttatac ctaccggcgg cagttcggca 1151 acagcctgtccatactccgg cacgaagcgg gcggcattgt cttcagcgtc 1201 agcggaatgg cgggaagccgcatcaggctt actccggaag acagcccgga 1251 acgcggtgta accctttatt tgcaggattg aThis corresponds to the amino acid sequence <SEQ ID 1550; ORF 537.ng>:

g537.pep 1 MKSLFIWLLL LGSAAGVFYH TQNQSLPAGE LVYPSAPQIR DGGDALHYLN 51RIRTQIGLHA LAHAPVLENS ARRHARYLTL NPEDGHGEHH PDNPHYTAQK 101 LTERTRLAGYLYNGVHENIS TEEEAAESSD SDIRTQQRQV DALMSAIYHR 151 LSLLDRHTDE AGAAFVRENGKTVLVFNQGN GSFERACAKG RRQPEAGRKY 201 YRNACHNGAA VYADEAMPVT ELLYTAYPVGGGALPYFYGE RPDPVPEYEI 251 TGNPASIDFS EAAGKIAMKS FKLYQGKNEI RPVRVLTAGNDPNGRLTAHQ 301 FALFPLKPLE YGTLYTAVFD YVRNGRHAQA KWQFRTRKPD YPYFEVNGGE351 TLAVRKGEKY FIHWRGRWCL EACTRYTYRR QFGNSLSILR HEAGGIVFSV 401SGMAGSRIRL TPEDSPERGV TLYLQD *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1551>:

m537.seq (partial) 1 ATGAAATCCC TTTTTATTCG GCTGCTCCTG TTGGGTTCGGCGGCAGGCGT 51 TTTCTACCAT ACCCAAAmCC AATCCCTGCC CGCGGGCGAA CTTGTCTATC 101CGTCCGCACC GCAAATCAGG GACGGCGGCG ATGCGCTGCA CTACCTCAAC 151 CGCATCCGAGCCCAAATCGG TTTGCACAAG CTGGCACACG CGCCGGTTTT 201 GGAAAACTCC GCCCGCAgGCACGCAAGCTA CCTCACGCTC AATCCCGAAG 251 ACGGACACGG CGAACACCAT CCCGACAATCCGCACTACAC CGCACAAAAG 301 CTGACCGAAC GCACACGCCT TGCCGGGTAT CTCTACAACGGCGTGCATGA 351 AAACATCAGC ACGGAAGAAG AAGCCGCCGA ATCGTCCGAC AGCGACATCC401 GCACGCAGCA ACGCCAAGTG GACGGATTAA TGAGCGCAAT CTACCACCGC 451CTTTCCCTAC TTGACCGCCA TACGGATGAG TCAGGAGCGG CATT...This corresponds to the amino acid sequence <SEQ ID 1552; ORF 537>:

m537.pep (partial) 1 MKSLFIRLLL LGSAAGVFYH TQXQSLPAGE LVYPSAPQIRDGGDALHYLN 51 RIRAQIGLHK LAHAPVLENS ARRHASYLTL NPEDGHGEHH PDNPHYTAQK 101LTERTRLAGY LYNGVHENIS TEEEAAESSD SDIRTQQRQV DGLMSAIYHR 151 LSLLDRHTDESGAA...Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 537 shows 95.7% identity over a 164 aa overlap with a predicted ORF(ORF 537.ng) from N. gonorrhoeae:

m537/g537         10        20        30        40        50        60m537.pep MKSLFIRLLLLGSAAGVFYHTQXQSLPAGELVYPSAPQIRDGGDALHYLNRIRAQIGLHK|||||| ||||||||||||||| ||||||||||||||||||||||||||||||:||||| g537MKSLFIWLLLLGSAAGVFYHTQNQSLPAGELVYPSAPQIRDGGDALHYLNRIRTQIGLHA        10        20        30        40        50        60        70        80        90       100       110       120 m537.pepLAHAPVLENSARRHASYLTLNPEDGHGEHHPDNPHYTAQKLTERTRLAGYLYNGVHENIS||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| g537LAHAPVLENSARRHARYLTLNPEDGHGEHHPDNPHYTAQKLTERTRLAGYLYNGVHENIS        70        80        90       100       110       120       130       140       150       160 m537.pepTEEEAAESSDSDIRTQQRQVDGLMSAIYHRLSLLDRHTDESGAA|||||||||||||||||||||:||||||||||||||||||:||| g537TEEEAAESSDSDIRTQQRQVDALMSAIYHRLSLLDRHTDEAGAAFVRENGKTVLVFNQGN       130       140       150       160       170       180 g537GSFERACAKGRRQPEAGRKYYRNACHNGAAVYADEAMPVTELLYTAYPVGGGALPYFYGE       190       200       210       220       230       240The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1553>:

a537.seq 1 ATGAAATCCC TTTTTATTCG GCTGCTCCTG TTGGGTTCGG CGGCCGGCGT 51TTTCTATCAT ACCCAAAACC AATCCCTGCC CGCGGGCGAA CTTGTCTATC 101 CGTCCGCACCGCAAATCAGG GACGGCGGCG ATGCGCTGCA CTACCTCAAC 151 CGCATCCGCG CCCAAATCGGTTTGCACAAG CTGGCACACG CGCCGGTTTT 201 GGAAAATTCC GCCCGCAGGC ACGCACGCTATCTCACGCTC AATCCCGAAG 251 ACGGACACGG CGAACACCAT CCCGACAATC CGCACTACACCGCACAAAAG 301 CTGACCGAAC GCACACGCCT TGCCGGGTAT CTCTACAACG GCGTGCATGA351 AAACATCAGC ACGGAAGAGG AAGCCGCCGA ATCGTCCGAC AGCGACATCC 401GCACGCAGCA ACGCCAAGTG GACGGATTAA TGAGCGCAAT CTACCACCGC 451 CTTTCCCTACTTGACCGCCA TACGGATGAG GCAGGAGCGG CATTTGTGCG 501 CGAAAACGGT AAAACCGTTCTCGTATTCAA TCAGGGCAAC GGCAGGTTTG 551 AGCGGCATTG CGCCCAAGGC AGAAATCAGCCGGAAGCAGG ACGGAAATAT 601 TACCGCAACG CCTGCCATAA CGGTGCGGTC GTGTACACCGACGAAGCCAT 651 GCCCGCACAG GAGCTGCTCT ATACAGCCTA TCCCGTCGGC AACGGCGCAC701 TGCCTTATTT CCACGGCGAG CGTCCAGACC CCGTGCCGGA ATATGAAATC 751ACGGGCAATC CTGCCAGCAT TGATTTTTCC GAGGCGGCAG GCAAAATTAC 801 GATGAAAAGTTTCAAGCTGT ATCAGGGTAA AAACGAAATC CGCCCCGTCA 851 GGGTTTTAAC CGCCGGCAACGACCCCAACG GCAGGCTGAC CGCGTACCAA 901 TTCGCGCTTT TCCCGCTCAA GCCTTTGGAATACGGTACGC TTTATACGGC 951 GGTATTCGAC TATGTCCGCA ACGGACGGCG CGCGCAGGCGAAATGGCAGT 1001 TTAGAACCCG AAAACCCGAT TACCCTTATT TTGAGGTAAA CGGCGGCGAG1051 ACACTTGCGG TTAGAAAAGG CGAAAAATAT TTCATCCACT GGCGCGGACG 1101CTGGTGTTTG GAAGCGTGTA CCCGTTATAC CTACCGGCAG CGACCCGGCA 1151 GCCGCCTGTCCATAGGAAGG CACAAGGCGG GCGGCATCGT CTTCAGCGTT 1201 GACGGAATGG CGGGCAGCCGCATCACGCTT GCACCGGAAG GAGAAACGGA 1251 ACGAGGCGTA ACCCTTTATT TACAGGATTG AThis corresponds to the amino acid sequence <SEQ ID 1554; ORF 537.a>:

a537.pep 1 MKSLFIRLLL LGSAAGVFYH TQNQSLPAGE LVYPSAPQIR DGGDALHYLN 51RIRAQIGLHK LAHAPVLENS ARRHARYLTL NPEDGHGEHH PDNPHYTAQK 101 LTERTRLAGYLYNGVHENIS TEEEAAESSD SDIRTQQRQV DGLMSAIYHR 151 LSLLDRHTDE AGAAFVRENGKTVLVFNQGN GRFERHCAQG RNQPEAGRKY 201 YRNACHNGAV VYTDEAMPAQ ELLYTAYPVGNGALPYFHGE RPDPVPEYEI 251 TGNPASIDFS EAAGKITMKS FKLYQGKNEI RPVRVLTAGNDPNGRLTAYQ 301 FALFPLKPLE YGTLYTAVFD YVRNGRRAQA KWQFRTRKPD YPYFEVNGGE351 TLAVRKGEKY FIHWRGRWCL EACTRYTYRQ RPGSRLSIGR HKAGGIVFSV 401DGMAGSRITL APEGETERGV TLYLQD* m537/a537 98.2% identity in 164 aa overlap        10        20        30        40        50        60 m537.pepMKSLFIRLLLLGSAAGVFYHTQXQSLPAGELVYPSAPQIRDGGDALHYLNRIRAQIGLHK|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| a537MKSLFIRLLLLGSAAGVFYHTQNQSLPAGELVYPSAPQIRDGGDALHYLNRIRAQIGLHK        10        20        30        40        50        60        70        80        90       100       110       120 m537.pepLAHAPVLENSARRHASYLTLNPEDGHGEHHPDNPHYTAQKLTERTRLAGYLYNGVHENIS||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| a537LAHAPVLENSARRHARYLTLNPEDGHGEHHPDNPHYTAQKLTERTRLAGYLYNGVHENIS        70        80        90       100       110       120       130       140       150       160 m537.pepTEEEAAESSDSDIRTQQRQVDGLMSAIYHRLSLLDRHTDESGAA||||||||||||||||||||||||||||||||||||||||:||| a537TEEEAAESSDSDIRTQQRQVDGLMSAIYHRLSLLDRHTDEAGAAFVRENGKTVLVFNQGN       130       140       150       160       170       180 a537GRFERHCAQGRNQPEAGRKYYRNACHNGAVVYTDEAMPAQELLYTAYPVGNGALPYFHGE       190       200       210       220       230       240The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1555>:

g538.seq 1 atgtcaggta gaacaggacg gaacagtgcc actcaggcgc aaccggaacg 51cgtcatgctg gtgggcgtaa tgttggataa agatgatacg ggcagcaatg 101 ccgcccgtctgaacggtttt cagacggcat tggcggaagc cgtcgagctg 151 gtcaaagcgg cgggcggcgattccgtacgc gtggagactg ccaaacgcga 201 ccgcccgcac actgcgctgt ttgtcggcacgggcaaggcg gcggagctgt 251 cggaagcagt tgccgcagac ggcattgatt tggtcgtattcaaccacgaa 301 cttactccca cgcaggaacg caatttggaa aaaatcctcc aatgccgcgt351 attggacaga gtggggctga ttctggcgat tttcgcccgc cgcgcccgca 401cgcaggaagg caggctgcaa gtcgagttgg cgcaattgag ccatttggcg 451 ggacgcttgatacgcggtta cggacatttg caaagccagc gcggcggtat 501 cggcatgaaa gggccgggcgaaaccaaact ggaaaccgac cgccgattaa 551 ccgcccatcg gatcaacgcc ttgaaaaaacagcttgccaa cctcaaaaaa 601 cagcgcgccc tgcgccgcaa gtcccgcgag tcgggcagaatcaaaacgtt 651 tgcgctggtc ggctatacca atgtcggcaa atccagcctg ttcaaccggc701 tgaccaagtc gggcatatat gcgaaagacc agcttttcgc cactctcgac 751acgacggcgc ggcggctgta catcagtccc gcatgcagca ttatcctgac 801 cgataccgtcggattcgtca gcgatctgcc gcacaaactg atttccgcct 851 tttccgccac cttggaagaaaccgtgcaag ccgatgtgct gctgcacgtc 901 gtcgatgctg ccgcccggaa cagcgggcagcagattgaag acgtggaaaa 951 cgtactgcaa gaaatccatg cccacgatat tccgtgcatcaaggtgtaca 1001 acaaaaccga cctgctgccg tctgaagaac aaaacacggg catatggcgc1051 gacgctgcgg gaaaaattgc cgccgtccgc atttccgttg ctgaaaatacThis corresponds to the amino acid sequence <SEQ ID 1556; ORF 538.ng>:

g538.pep 1 MSGRTGRNSA TQAQPERVML VGVMLDKDDT GSNAARLNGF QTALAEAVEL 51VKAAGGDSVR VETAKRDRPH TALFVGTGKA AELSEAVAAD GIDLVVFNHE 101 LTPTQERNLEKILQCRVLDR VGLILAIFAR RARTQEGRLQ VELAQLSHLA 151 GRLIRGYGHL QSQRGGIGMKGPGETKLETD RRLTAHRINA LKKQLANLKK 201 QRALRRKSRE SGRIKTFALV GYTNVGKSSLFNRLTKSGIY AKDQLFATLD 251 TTARRLYISP ACSIILTDTV GFVSDLPHKL ISAFSATLEETVQADVLLHV 301 VDAAARNSGQ QIEDVENVLQ EIHAHDIPCI KVYNKTDLLP SEEQNTGIWR351 DAAGKIAAVR ISVAENTGID ALREAIAEYC AAAPNTDETE MP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1557>:

m538.seq 1 ATGACAGGCA GAACAGGCGG CAACGGCAGT ACCCAAGCGC AACCCGAACG 51CGTCATGCTG GTGGGCGTAA TGTTGGACAA AGATGGTACG GGCAGTAGTG 101 CCGCCCGTCTGAACGGTTTT CAGACGGCAT TGGCGGAAGC TGTCGAGCTG 151 GTCAAAGCGG CGGGCGGCGATTCCGTGCGC GTGGAGACTG CCAAACGCGA 201 CCGTCCGCAC ACCGCGCTGT TTGTCGGCACGGGCAAGGCG GCGGAGCTGT 251 CAGAAGCAGT TGCCGCAGAC GGCATCGATT TGGTCGTATTCAACCACGAA 301 CTCACGCCCA CGCAGGAACG CAACCTTGAA AAAGAACTsA AATGCCGCGT351 ATTGGACAGG GTAGGGCTGA TTCTGGCGAT TTTCGCTCGC CGCGCCCGCA 401CGCAGGAAGG CAGGCTGCAA GTCGAGTTGG CGCAATTGAG CCATTTGGCG 451 GGACGCTTGATACGCGGTTA CGGCCATCTG CAGAGCCAGC GCGGCGGTAT 501 CGGCATGAAA GGCCCCGGCGAAACCAAACT GGAAACCGAC CGCCGATTGA 551 TCGCCCATCG GATCAATGCC TTGATAAAACAGCTTGCCAA CCTCAAAAAA 601 CAGCGCGCCC TGCGCCGCAA GTCnCGCGAA TCGGGCACAATCAAAACGTT 651 TGCGCTGGTC GGCTATACAA ATGTCGGAAA ATCCAGCCTG TTCAACCGGC701 TGACAAAGTC GGGCATATAT GCAAAGGACA AGCTTAGTCC CGAATGCAGC 751ATTATCCTGA CCGATACCGT CGGATTCGTn AGCGATCTGC CGCAcAAACT 801 GATTTCCGCCTTTTCgCC.A CGCTGGAAGA AACCGCGCAA GCCGATGTGC 851 TGCTGCACGT CGTCGATGCCGCCGCTCCGA ACAGCGGACA GCAGATTGAA 901 GACGTGGAAA ACGTACTGCA AGAAATCCATGCCGGCGATA TTCCGTGCAT 951 cAAGGTGTAC AACAAAACCG ACCTGCTGCC GTCTGAAGAACAAAACACGG 1001 GCATATGGCG CGACGCTGCG GGAAAAATTG CCGCCGTCCG CATTTCCGTT1051 GCTGAAAATA CCGGTATAGA CGCACTGCGC GAAGCcATTG CCGAGTCTTG 1101TGCCGCCGCA CCAAACACAG ACGAAACCGA AATGCCATGAThis corresponds to the amino acid sequence <SEQ ID 1558; ORF 538>:

m538.pep 1 MTGRTGGNGS TQAQPERVML VGVMLDKDGT GSSAARLNGF QTALAEAVEL 51VKAAGGDSVR VETAKRDRPH TALFVGTGKA AELSEAVAAD GIDLVVFNHE 101 LTPTQERNLEKELKCRVLDR VGLILAIFAR RARTQEGRLQ VELAQLSHLA 151 GRLIRGYGHL QSQRGGIGMKGPGETKLETD RRLIAHRINA LIKQLANLKK 201 QRALRRKSRE SGTIKTFALV GYTNVGKSSLFNRLTKSGIY AKDKLSPECS 251 IILTDTVGFV SDLPHKLISA FSXTLEETAQ ADVLLHVVDAAAPNSGQQIE 301 DVENVLQEIH AGDIPCIKVY NKTDLLPSEE QNTGIWRDAA GKIAAVRISV351 AENTGIDALR EAIAESCAAA PNTDETEMP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 538 shows 92.1% identity over a 392 aa overlap with a predicted ORF(ORF 538.ng) from N. gonorrhoeae:

m538/g538         10        20        30        40        50        60m538.pep MTGRTGGNGSTQAQPERVMLVGVMLDKDGTGSSAARLNGFQTALAEAVELVKAAGGDSVR|:|||| |::|||||||||||||||||| |||:||||||||||||||||||||||||||| g538MSGRTGRNSATQAQPERVMLVGVMLDKDDTGSNAARLNGFQTALAEAVELVKAAGGDSVR        10        20        30        40        50        60        70        80        90       100       110       120 m538.pepVETAKRDRPHTALFVGTGKAAELSEAVAADGIDLVVFNHELTPTQERNLEKELKCRVLDR||||||||||||||||||||||||||||||||||||||||||||||||||| |:|||||| g538VETAKRDRPHTALFVGTGKAAELSEAVAADGIDLVVFNHELTPTQERNLEKILQCRVLDR        70        80        90       100       110       120       130       140       150       160       170       180 m538.pepVGLILAIFARRARTQEGRLQVELAQLSHLAGRLIRGYGHLQSQRGGIGMKGPGETKLETD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g538VGLILAIFARRARTQEGRLQVELAQLSHLAGRLIRGYGHLQSQRGGIGMKGPGETKLETD       130       140       150       160       170       180       190       200       210       220       230       240 m538.pepRRLIAHRINALIKQLANLKKQRALRRKSRESGTIKTFALVGYTNVGKSSLFNRLTKSGIY||| ||||||| |||||||||||||||||||| ||||||||||||||||||||||||||| g538RRLTAHRINALKKQLANLKKQRALRRKSRESGRIKTFALVGYTNVGKSSLFNRLTKSGIY       190       200       210       220       230       240                    250       260       270       280 m538.pepAKDKL-------------SPECSIILTDTVGFVSDLPHKLISAFSXTLEETAQADVLLHV|||:|             || |||||||||||||||||||||||| |||||:|||||||| g538AKDQLFAILDTTARRLYISPACSIILTDTVGFVSDLPHKLISAFSATLEETVQADVLLHV       250       260       270       280       290       300290       300       310       320       330       340 m538.pepVDAAAPNSGQQIEDVENVLQEIHAGDIPCIKVYNKTDLLPSEEQNTGIWRDAAGKIAAVR||||| |||||||||||||||||| ||||||||||||||||||||||||||||||||||| g538VDAAARNSGQQIEDVENVLQEIHAHDIPCIKVYNKTDLLPSEEQNTGIWRDAAGKIAAVR       310       320       330       340       350       360350       360       370       380 m538.pepISVAENTGIDALREAIAESCAAAPNTDETEMPX |||||||||||||||||| |||||||||||||| g538ISVAENTGIDALREAIAEYCAAAPNTDETEMPXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1559>:

a538.seq 1 ATGACAGGCA GAACAGGCCG CAACGGCAGT ACCCAAGCGC AACCCGAACG 51CGTCATGCTG GTGGGCGTAA TGTTGGACAA AGATGGTACG GGCAGCAGTG 101 CCACCCGTCTGAACGGTTTT CAGACGGCAT TGGCGGAAGC TGTCGAGCTG 151 GTCAAAGCGG CGGGCGGCGATTCCGTGCGC GTGGAGACTG CCAAACGCGA 201 CCGTCCGCAC ACCGCGCTGT TTGTCGGCACGGGCAAGGCG GCGGAGCTGT 251 CGGAAGCAGT TGCCGCAGAC GGCATCGATT TGGTCGTATTCAACCACGAA 301 CTTACGCCCA CGCAGGAACG CAATTTGGAA AAAATCCTCC AATGCCGCGT351 ATTGGACAGA GTGGGGCTGA TTCTGGCGAT TTTCGCCCGC CGCGCCCGCA 401CGCAGGAAGG CAGGCTGCAA GTCGAGTTGG CACAATTGAG CCATTTGGCG 451 GGACGCTTGATACGCGGTTA CGGCCATCTG CAGAGCCAGC GCGGCGGTAT 501 CGGCATGAAA GGCCCCGGCGAAACCAAACT GGAAACCGAC CGCCGATTGA 551 TCGCCCATCG GATCAATGCC TTGAAAAAACAGCTTGCCAA CCTCAAAAAA 601 CAGCGCGCCC TGCGCCGCAA GTCCCGCGAA TCGGGCACAATCAAAACGTT 651 TGCGCTGGTC GGCTATACCA ATGTCGGCAA ATCCAGTCTG TTCAACCGGC701 TGACCAAGTC GGGCATATAT GCGAAAGACC AGCTTTTCGC CACACTCGAC 751ACGACGGCGC GGCGGCTGTA CATCAGTCCC GAATGCAGCA TTATCCTGAC 801 CGATACCGTCGGATTCGTCA GCGATCTGCC GCACAAACTG ATTTCCGCCT 851 TTTCCGCCAC GCTGGAAGAAACCGCGCAAG CCGATGTGCT GCTGCACGTC 901 GTCGATGCCG CCGCTCCGAA CAGCGGACAGCAGATTGAAG ACGTGGAAAA 951 CGTACTGCAA GAAATCCATG CCGGCGATAT TCCGTGCATCAAGGTGTACA 1001 ACAAAACCGA CCTGCTGCCG TCTGAAGAAC AAAACACGGG CATATGGCGC1051 GACGCTGCGG GAAAAATTGC CGCCGTCCGC ATTTCCGTTG CTGAAAATAC 1101CGGTATAGAC GCACTGCGCG AAGCCATTGC CGAGTATTGT GCCGCCGCAC 1151 CAAACACAGACGAAACCGAA ATGCCATGAThis corresponds to the amino acid sequence <SEQ ID 1560; ORF 538.a>:

a538.pep 1 MTGRTGRNGS TQAQPERVML VGVMLDKDGT GSSATRLNGF QTALAEAVEL 51VKAAGGDSVR VETAKRDRPH TALFVGTGKA AELSEAVAAD GIDLVVFNHE 101 LTPTQERNLEKILQCRVLDR VGLILAIFAR RARTQEGRLQ VELAQLSHLA 151 GRLIRGYGHL QSQRGGIGMKGPGETKLETD RRLIAHRINA LKKQLANLKK 201 QRALRRKSRE SGTIKTFALV GYTNVGKSSLFNRLTKSGIY AKDQLFATLD 251 TTARRLYISP ECSIILTDTV GFVSDLPHKL ISAFSATLEETAQADVLLHV 301 VDAAAPNSGQ QIEDVENVLQ EIHAGDIPCI KVYNKTDLLP SEEQNTGIWR351 DAAGKIAAVR ISVAENTGID ALREAIAEYC AAAPNTDETE MP* m538/a538 94.6%identity in 392 aa overlap        10        20        30        40        50        60 m538.pepMTGRTGGNGSTQAQPERVMLVGVMLDKDGTGSSAARLNGFQTALAEAVELVKAAGGDSVR|||||| |||||||||||||||||||||||||||:||||||||||||||||||||||||| a538MTGRTGRNGSTQAQPERVMLVGVMLDKDGTGSSATRLNGFQTALAEAVELVKAAGGDSVR        10        20        30        40        50        60        70        80        90       100       110       120 m538.pepVETAKRDRPHTALFVGTGKAAELSEAVAADGIDLVVFNHELTPTQERNLEKELKCRVLDR||||||||||||||||||||||||||||||||||||||||||||||||||| |:|||||| a538VETAKRDRPHTALFVGTGKAAELSEAVAADGIDLVVFNHELTPTQERNLEKILQCRVLDR        70        80        90       100       110       120       130       140       150       160       170       180 m538.pepVGLILAIFARRARTQEGRLQVELAQLSHLAGRLIRGYGHLQSQRGGIGMKGPGETKLETD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a538VGLILAIFARRARTQEGRLQVELAQLSHLAGRLIRGYGHLQSQRGGIGMKGPGETKLETD       130       140       150       160       170       180       190       200       210       220       230       240 m538.pepRRLIAHRINALIKQLANLKKQRALRRKSRESGTIKTFALVGYTNVGKSSLFNRLTKSGIY||||||||||| |||||||||||||||||||||||||||||||||||||||||||||||| a538RRLIAHRINALKKQLANLKKQRALRRKSRESGTIKTFALVGYTNVGKSSLFNRLTKSGIY       190       200       210       220       230       240                    250       260       270       280 m538.pepAKDKL-------------SPECSIILTDTVGFVSDLPHKLISAFSXTLEETAQADVLLHV|||:|             ||||||||||||||||||||||||||| |||||||||||||| a538AKDQLFATLDTTARRLYISPECSIILTDTVGFVSDLPHKLISAFSATLEETAQADVLLHV       250       260       270       280       290       300290       300       310       320       330       340 m538.pepVDAAAPNSGQQIEDVENVLQEIHAGDIPCIKVYNKTDLLPSEEQNTGIWRDAAGKIAAVR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a538VDAAAPNSGQQIEDVENVLQEIHAGDIPCIKVYNKTDLLPSEEQNTGIWRDAAGKIAAVR       310       320       330       340       350       360350       360       370       380 m538.pepISVAENTGIDALREAIAESCAAAPNTDETEMPX |||||||||||||||||| |||||||||||||| a538ISVAENTGIDALREAIAEYCAAAPNTDETEMPX        370       380       390The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1561>:

g539.seq 1 atggaggatc tgcaggaaat cgggttcgat gtcgccgccg taaaggtagg 51tcggcagcgc gaacatcatc gtctgcatca tacccagtcc ggcaacggca 101 aggcggacgatgtattgttt gcgttctttt tggttggcgg cttcgatttt 151 ttgcgcgtca tagggtgcggcggtgtagcc tgtctgccgg attttcaaca 201 gaatgtcgga gaggcggatt ttgccgtcgtcccagacgac gcggcagcgg 251 tgcgtgctgt aattgaggtc gatgcggacg atgccgtctgtgcgcaaaag 301 ctgctgttcg atcagccaga cgcaggcggc gcaggtaatg ccgctgagca351 tcagcactgc ttcgtgcgtg ccattatggg tttccacaaa gtcggattgg 401acttcgggca ggtcgtacag gcggatttgg tcgaggattt cttggggcgg 451 cagttcggtttttttcgcgt cggcggtgcg tcgtttgtaa taactgccca 501 agccggaatc gatgatgctttgtgcgactg cctgacagcc gacgcagcag 551 gtttcgcggt cttcgccttc gtagcggacggtcagatgca ggttttcggg 601 aacgtccagc ccgcagtgga aacaggtttt tttcatggcatttcggtttc 651 gtctgtgttt ggtgcggcgg cacaatactc ggcaatggct tcgcgcagtg701 cgtctatacc ggtattttca gcaacggaaa tgcggacggc ggcaattttt 751cccgcagcgt cgcgccatat gcccgtgttt tgttcttcag acggcagcag 801 gtcggttttgttgtacacct tgatgcacgg aatatcgtgg gcatggattt 851 cttgcagtac gttttccacgtcttcaatct gctgcccgct gttccgggcg 901 gcagcatcga cgacgtgcag cagcacatcggcttgcacgg tttcttccaa 951 ggtggcggaa aaggcggaaa tcagtttgtg cggcagatcgctgacgaatc 1001 cgacggtatc ggtcaggata atgctgcatg cgggactgat gtacagccgc1051 cgcgccgtcg tgtcgagagt ggcgaaaagc tggtctttcg catatatgcc 1101cgacttggtc agccggttga acaggctgga tttgccgaca ttggtatagThis corresponds to the amino acid sequence <SEQ ID 1562; ORF 539.ng>:

g539.pep 1 MEDLQEIGFD VAAVKVGRQR EHHRLHHTQS GNGKADDVLF AFFLVGGFDF 51LRVIGCGGVA CLPDFQQNVG EADFAVVPDD AAAVRAVIEV DADDAVCAQK 101 LLFDQPDAGGAGNAAEHQHC FVRAIMGFHK VGLDFGQVVQ ADLVEDFLGR 151 QFGFFRVGGA SFVITAQAGIDDALCDCLTA DAAGFAVFAF VADGQMQVFG 201 NVQPAVETGF FHGISVSSVF GAAAQYSAMASRSASIPVFS ATEMRTAAIF 251 PAASRHMPVF CSSDGSRSVL LYTLMHGISW AWISCSTFSTSSICCPLFRA 301 AASTTCSSTS ACTVSSKVAE KAEISLCGRS LTNPTVSVRI MLHAGLMYSR351 RAVVSRVAKS WSFAYMPDLV SRLNRLDLPT LV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1563>:

m539.seq (partial) 1 ATGGAGGATT TGCAGGAAAT CGGGTTCGAT GTCGCCGCCGTAAAGGTAGG 51 TCGGCAGCGC GAACATCATC GTCTGCATCA TCCCCAGCCC GGCAACGGCG 101AGGCGGACGA TGTATTGTTT GCGTTCTTTT TGGTTGGCGG CTTCGATTTT 151 TTGCGCGTCATAGGGTGCGG CGGTGTAGCC TATCTGCCTG ATTTTCAACA 201 GAATGTCGGA AAGGCGGATTTTGCCGTCGT CCCAGACGAc GCGGCaGCgG 251 TGCGTGCTGT AATTGAGGTC GATGCGGACGATGCCGTCTG TACGCAAAAG 301 CTGCTGTTCG ATCAGCCAGA CGCAGGCGGC GCAGGTGATGCCGCCGAGCA 351 TTAAAACCGC CTCGCGCGTG CCGCCGTGGG TTTCCACAAA GTCGGACTGG401 ACTTCGGGCA GGTCGTACAG GCGGATTTGG TCGAGGATTT CTTGGGGCGG 451CAgCTCGGTT TTTTGCGCGT CGGCGGTGCG TTGTTTGTAA TAACTGCCCA 501 AGCCCGCGTCAATAATGCTT TGTGCGACCG CCTGACAGCC GGCGCaCAgG 551 GTTTCGCGGT CTTCGTTTTCGTAACGGACA GTCAGGTGGA GGTGTTCGGG 601 AACATCCAGA CCGCAGTGGA AACAGGTTTTTTTCATGGCA TTTCGGTTTC 651 GTCTGTGTTT GGTGCGGCGG CACAAGACTC GGCAATgGCTTCGCGCAGTG 701 CGTCTATACC GGTATTTTCA GCAACGGAAA TGCGGACGGC GGCAATTTTT751 CCCGCAGCGT CGCGCCATAT GTCTGTGTTT TGTTCTTCAG ACGGCAGCAG 801GTCGGTTTTG TTGTACACCT TgATGCACGG AATATCGCCG GCATGGATTT 851 CTTGCAGTACGTTTTCCACG TCTTCAATCT GCTGTCCGCT GTTCGGAGCG 901 GCGGCATCGA CGACGTGCAGCAGCACATCG GCTTGCGCGG TTTCTTCCAG 951 CGTGGcG.AA AAGGCGGAAA TCAGTTTgTGCGGCAGATCG CTnACGAATC 1001 CGACGGTATC GGTCAGGATA ATGCTGCATT CGGGAC...This corresponds to the amino acid sequence <SEQ ID 1564; ORF 539>:

m539.pep (partial) 1 MEDLQEIGFD VAAVKVGRQR EHHRLHHPQPGNGEADDVLF AFFLVGGFDF 51 LRVIGCGGVA YLPDFQQNVG KADFAVVPDD AAAVRAVIEVDADDAVCTQK 101 LLFDQPDAGG AGDAAEH*NR LARAAVGFHK VGLDFGQVVQ ADLVEDFLGR151 QLGFLRVGGA LFVITAQARV NNALCDRLTA GAQGFAVFVF VTDSQVEVFG 201NIQTAVETGF FHGISVSSVF GAAAQDSAMA SRSASIPVFS ATEMRTAAIF 251 PAASRHMPVFCSSDGSRSVL LYTLMHGISP AWISCSTFST SSICCPLFGA 301 AASTTCSSTS ACAVSSSVAXKAEISLCGRS LTNPTVSVRI MLHSG....Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 539 shows 89% identity over a 345 aa overlap with a predicted ORF(ORF 539.ng) from N. gonorrhoeae:

m539/g539         10        20        30        40        50        60m539.pep MEDLQEIGFDVAAVKVGRQREHHRLHHPQPGNGEADDVLFAFFLVGGFDFLRVIGCGGVA||||||||||||||||||||||||||| | |||:|||||||||||||||||||||||||| g539MEDLQEIGFDVAAVKVGRQREHHRLHHTQSGNGKADDVLFAFFLVGGFDFLRVIGCGGVA        10        20        30        40        50        60        70        80        90       100       110       120 m539.pepYLPDFQQNVGKADFAVVPDDAAAVRAVIEVDADDAVCTQKLLFDQPDAGGAGDAAEHXNR |||||||||:||||||||||||||||||||||||||:||||||||||||||:|||| : g539CLPDFQQNVGEADFAVVPDDAAAVRAVIEVDADDAVCAQKLLFDQPDAGGAGNAAEHQHC        70        80        90       100       110       120       130       140       150       160       170       180 m539.pepLARAAVGFHKVGLDFGQVVQADLVEDFLGRQLGFLRVGGALFVITAQARVNNALCDRLTA::|| :|||||||||||||||||||||||||:||:||||| ||||||| :::|||| ||| g539FVRAIMGFHKVGLDFGQVVQADLVEDFLGRQFGFFRVGGASFVITAQAGIDDALCDCLTA       130       140       150       160       170       180       190       200       210       220       230       240 m539.pepGAQGFAVFVFVTDSQVEVFGNIQTAVETGFFHGISVSSVFGAAAQDSAMASRSASIPVFS | |||||:||:|:|::||||:| ||||||||||||||||||||| |||||||||||||| g539DAAGFAVFAFVADGQMQVFGNVQPAVETGFFHGISVSSVFGAAAQYSAMASRSASIPVFS       190       200       210       220       230       240       250       260       270       280       290       300 m539.pepATEMRTAAIFPAASRHMPVFCSSDGSRSVLLYTLMHGISPAWISCSTFSTSSICCPLFGA||||||||||||||||||||||||||||||||||||||| |||||||||||||||||| | g539ATEMRTAAIFPAASRHMPVFCSSDGSRSVLLYTLMHGISWAWISCSTFSTSSICCPLFRA       250       260       270       280       290       300       310       320       330       340 m539.pepAASTTCSSTSACAVSSSVAXKAEISLCGRSLTNPTVSVRIMLHSG||||||||||||:|||:|| |||||||||||||||||||||||:| g539AASTTCSSTSACTVSSKVAEKAEISLCGRSLTNPTVSVRIMLHAGLMYSRRAVVSRVAKS       310       320       330       340       350       360 g539WSFAYMPDLVSRLNRLDLPTLV        370       380The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1565>:

a539.seq 1 ATGGAGGATT TGCAGGAAAT CGGGTTCGAT GTCGCCGCCG TAAAGGTAGG 51TCGGCAGCGC GAACATCATC GTCTGCATCA TCCCCAGCCC GGCAACGGCG 101 AGGCGGACGATGTATTGTTT GCGTTCTTTT TGGTTGGCGG CTTCGATTTT 151 TTGCGCGTCA TAGGGTGCGGCGGTGTAGCC TATCTGCCTG ATTTTCAACA 201 GAATGTCGGA AAGGCGGATT TTGCCGTCGTCCCAGACGAC GCGGCAGCGG 251 TGCGTGCTGT AATTGAGGTC GATGCGGACG ATGCCGTCTGTACGCAAAAG 301 CTGCTGTTCG ATCAGCCAGA CGCAGGCGGC GCAGGTGATG CCGCCGAGCA351 TTAAAACCGC CTCGCGCGTG CCGCCGTGGG TTTCCACAAA GTCGGACTGG 401ACTTCGGGCA GGTCGTACAG GCGGATTTGG TCGAGGATTT CTTGGGGCGG 451 CAGCTCGGTTTTTTGCGCGT CGGCGGTGCG TTGTTTGTAA TAACTGCCCA 501 AGCCCGCGTC AATAATGCTTTGTGCGACTG CCTGACAACC GGCGCAGCAG 551 GTTTCGCGGT CTTCGTTTTC GTAACGGACGGTCAGATGCA GGTTTTCGGG 601 AACGTCCAGC CCGCAGTGGA AACAGGTTTT TTTCATGGCATTTCGGTTTC 651 GTCTGTGTTT GGTGCGGCGG CACAATACTC GGCAATGGCT TCGCGCAGTG701 CGTCTATACC GGTATTTTCA GCAACGGAAA TGCGGACGGC GGCAATTTTT 751CCCGCAGCGT CGCGCCATAT GCCCGTGTTT TGTTCTTCAG ACGGCAGCAG 801 GTCGGTTTTGTTGTACACCT TGATGCACGG AATATCGCCG GCATGGATTT 851 CTTGCAGTAC GTTTTCCACGTCTTCAATCT GCTGTCCGCT GTTCGGAGCG 901 GCGGCATCGA CGACGTGCAG CAGCACATCGGCTTGCGCGG TTTCTTCCAG 951 CGTGGCGGAA AAGGCGGAAA TCAGTTTGTG CGGCAGATCGCTGACGAATC 1001 CGACGGTATC GGTCAGGATA ATGCTGCATT CGGGACTGAT GTACAGCCGC1051 CGCGCCGTCG TGTCGAGTGT GGCGAAAAGC TGGTCTTTCG CATATATGCC 1101CGACTTGGTC AGCCGGTTGA ACAGACTGGA TTTGCCGACA TTGGTATAGThis corresponds to the amino acid sequence <SEQ ID 1566; ORF 539.a>:

a539.pep 1 MEDLQEIGFD VAAVKVGRQR EHHRLHHPQP GNGEADDVLF AFFLVGGFDF 51LRVIGCGGVA YLPDFQQNVG KADFAVVPDD AAAVRAVIEV DADDAVCTQK 101 LLFDQPDAGGAGDAAEH*NR LARAAVGFHK VGLDFGQVVQ ADLVEDFLGR 151 QLGFLRVGGA LFVITAQARVNNALCDCLTT GAAGFAVFVF VTDGQMQVFG 201 NVQPAVETGF FHGISVSSVF GAAAQYSAMASRSASIPVFS ATEMRTAAIF 251 PAASRHMPVF CSSDGSRSVL LYTLMHGISP AWISCSTFSTSSICCPLFGA 301 AASTTCSSTS ACAVSSSVAE KAEISLCGRS LTNPTVSVRI MLHSGLMYSR351 RAVVSSVAKS WSFAYMPDLV SRLNRLDLPT LV* m539/a539 97.1% identity in 345aa overlap         10        20        30        40        50        60m539.pep MEDLQEIGFDVAAVKVGRQREHHRLHHPQPGNGEADDVLFAFFLVGGFDFLRVIGCGGVA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a539MEDLQEIGFDVAAVKVGRQREHHRLHHPQPGNGEADDVLFAFFLVGGFDFLRVIGCGGVA        10        20        30        40        50        60        70        80        90       100       110       120 m539.pepYLPDFQQNVGKADFAVVPDDAAAVRAVIEVDADDAVCTQKLLFDQPDAGGAGDAAEHXNR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a539YLPDFQQNVGKADFAVVPDDAAAVRAVIEVDADDAVCTQKLLFDQPDAGGAGDAAEHXNR        70        80        90       100       110       120       130       140       150       160       170       180 m539.pepLARAAVGFHKVGLDFGQVVQADLVEDFLGRQLGFLRVGGALFVITAQARVNNALCDRLTA|||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||: a539LARAAVGFHKVGLDFGQVVQADLVEDFLGRQLGFLRVGGALFVITAQARVNNALCDCLTT       130       140       150       160       170       180       190       200       210       220       230       240 m539.pepGAQGFAVFVFVTDSQVEVFGNIQTAVETGFFHGISVSSVFGAAAQDSAMASRSASIPVFS|| ||||||||||:|::||||:| ||||||||||||||||||||| |||||||||||||| a539GAAGFAVFVFVTDGQMQVFGNVQPAVETGFFHGISVSSVFGAAAQYSAMASRSASIPVFS       190       200       210       220       230       240       250       260       270       280       290       300 m539.pepATEMRTAAIFPAASRHMPVFCSSDGSRSVLLYTLMHGISPAWISCSTFSTSSICCPLFGA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a539ATEMRTAAIFPAASRHMPVFCSSDGSRSVLLYTLMHGISPAWISCSTFSTSSICCPLFGA       250       260       270       280       290       300       310       320       330       340 m539.pepAASTTCSSTSACAVSSSVAXKAEISLCGRSLTNPTVSVRIMLHSG||||||||||||||||||| ||||||||||||||||||||||||| a539AASTTCSSTSACAVSSSVAEKAEISLCGRSLTNPTVSVRIMLHSGLMYSRRAVVSSVAKS       310       320       330       340       350       360 a539WSFAYMPDLVSRLNRLDLPTLVX        370       380The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1567>:

g540.seq 1 atgccgccct cccgacgcgg caacggggtg ttttatcaaa acggcaaact 51tgccaatgcg gtttccgctt gccgattgcc aaaccggcaa acctttcccg 101 tgccggtgccgaacccgatg ccgtctgaac cttcagacgg catcgggtgt 151 ttatttgtcc actcggacgggtgcaggttc gtattgtgtc gattcgtcgc 201 cgtaatacag cacgccgagt ttgacggggatgcgtccctg cgatttgcgg 251 tgggcgttgg aatcgcgcaa ggaatacgcg cagccgcagtattcctgctg 301 gtagaagttt tcgcgtttgc tgatttcaat catacgcgcg ccgccgccgc351 ctttgcgcca gttgaagtcc caataggcca catcatcgta aggcgcggcg 401gcacggtgtc cgcagtcgtt gatttgcgcc atatttttcc agcgtgaThis corresponds to the amino acid sequence <SEQ ID 1568; ORF 540.ng>:

g540.pep 1 MPPSRRGNGV FYQNGKLANA VSACRLPNRQ TFPVPVPNPM PSEPSDGIGC 51LFVHSDGCRF VLCRFVAVIQ HAEFDGDASL RFAVGVGIAQ GIRAAAVFLL 101 VEVFAFADFNHTRAAAAFAP VEVPIGHIIV RRGGTVSAVV DLRHIFPA *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1569>:

m540.seq (partial) 1 ..CCGAACCCGA TGCCGTCTGA ACCTTCAGAC GGCATCGGGTGTTTATTTGT 51   CCACCCGGAT GGGGGCAGGT TCGTATTGTG TCGATTCGTC GCCGTAATAC101   AGCACGCCGA GTTTGATGGG GATTCTGCCC TGTGATTTGC GGTGGGCATT 151  GGAATCCCTC AGGGAATAGG CACAACCGCA ATATTCCTGC TGGTAGAAGT 201  TTTCACGTTT GCTGATTTCA ATCATGCGCG CGCTGCCGCC GCCTTTGCGC 251  CAGTTGAAAT CCCAATACAC CACATCATCG TAAGGCGCGG CGGCGCGGTG 301  TCCGCAGTCG TTGATTTGCG CCATATTTTT CCAGCGTGAThis corresponds to the amino acid sequence <SEQ ID 1570; ORF 540>:

m540.pep (partial) 1 ..PNPMPSEPSD GIGCLFVHPD GGRFVLCRFV AVIQHAEFDGDSAL*FAVGI 51   GIPQGIGTTA IFLLVEVFTF ADFNHARAAA AFAPVEIPIH HIIVRRGGAV101   SAVVDLRHIF PA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 540 shows 85.7% identity over a 112 aa overlap with a predicted ORF(ORF 540.ng) from N. gonorrhoeae:

m540/g540                                       10        20        30m540.pep                               PNPMPSEPSDGIGCLFVHPDGGRFVLCRFV                              |||||||||||||||||| || |||||||| g540GNGVFYQNGKLANAVSACRLPNRQTFPVPVPNPMPSEPSDGIGCLFVHSDGCRFVLCRFV  10        20        30        40        50        60        40        50        60        70        80        90 m540.pepAVIQHAEFDGDSALXFAVGIGIPQGIGTTAIFLLVEVFTFADFNHARAAAAFAPVEIPIH|||||||||||::| ||||:|| ||| ::|:|||||||:||||||:||||||||||:|| g540AVIQHAEFDGDASLRFAVGVGIAQGIRAAAVFLLVEVFAFADFNHTRAAAAFAPVEVPIG  70        80        90       100       110       120       100       110 m540.pep HIIVRRGGAVSAVVDLRHIFPAX||||||||:|||||||||||||| g540 HIIVRRGGTVSAVVDLRHIFPAX  130       140L′ estremita′ N-terminale di meningococ co e′ assente perche′ intervienela fine del contigThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1571>:

a540.seq 1 ATGCCGTCCT CCCGACGCGG CAACGGGGTG TTTTATCAAA ACGGCAAACT 51TGCCAATGCG GTTTCCGATT GCAGATTGCC AAACCGGCAA ACCTTTCCCG 101 TGCCGATGCCGAACCCGATG CCGTCTGAAC CTTCAGACGG CATCGGGTGT 151 TTATTTGTCC ACCCGGATGGGTGCAGGTTC GTATTGTGTC GATTCGTCGC 201 CGTAATACAG CACGCCGAGT TTGATGGGGATTCTGCCCTG TGATTTGCGG 251 TGGGCGTTGG AATCCCTCAG GGAATAGGCA CAACCGCAATATTCCTGCTG 301 GTAGAAGTTT TCACGTTTGC TGATTTCAAT CATACGCGCG CTGCCGCCGC351 CTTTGCGCCA GTTGAAATCC CAATACACCA CATCATCGTA AGGCGCGGCG 401GCGCGGCGGC CGCAGTCGTT AATCTGGTTC ATGTTTTTCC AThis corresponds to the amino acid sequence <SEQ ID 1572; ORF 540.a>:

a540.pep (partial) 1 MPSSRRGNGV FYQNGKLANA VSDCRLPNRQ TFPVPMPNPMPSEPSDGIGC 51 LFVHPDGCRF VLCRFVAVIQ HAEFDGDSAL *FAVGVGIPQ GIGTTAIFLL 101VEFTFADFN HTRAAAAFAP VEIPIHHIIV RRGGAAAAVV NLVHVFP m540/a540 92.8%identity in 111 aa overlap                                      10        20        30 m540.pep                              PNPMPSEPSDGIGCLFVHPDGGRFVLCRFV                              ||||||||||||||||||||| |||||||| a540GNGVFYQNGKLANAVSDCRLPNRQTFPVPMPNPMPSEPSDGIGCLFVHPDGCRFVLCRFV  10        20        30        40        50        60        40        50        60        70        80        90 m540.pepAVIQHAEFDGDSALXFAVGIGIPQGIGTTAIFLLVEVFTFADFNHARAAAAFAPVEIPIH|||||||||||||||||||:|||||||||||||||||||||||||:|||||||||||||| a540AVIQHAEFDGDSALXFAVGVGIPQGIGTTAIFLLVEVFTFADFNHTRAAAAFAPVEIPIH  70        80        90       100       110       120       100       110 m540.pep HIIVRRGGAVSAVVDLRHIFPAX|||||||||::|||:| |:|| a540 HIIVRRGGAAAAVVNLVHVFP  130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1573>:

g542.seq 1 atgccgaaat ggtcgcgcat acggcgttgc agcgtccttt cgctgatgtt 51cagcgcggct gtcagccggt tgacttggtg tgcgccgccg tcgaacgcgg 101 cattcagggtgcggctgaag tcttcagacg gcatagcgtc tgcttccgcc 151 gtttgccccg ccgccggctcgatgccgtct gaaaccgtgt cccacaaatc 201 cgacagcagc cgcaacacgt ccgcctcgcggcgcaatgtt tcgcccaaat 251 gcccctttgg gacggtttgc aggcaggatg ccgccaagccgcgcaggttt 301 gggggcaaat cccatatcct gaccggttcg cggtaaThis corresponds to the amino acid sequence <SEQ ID 1574; ORF 542.ng>:

g542.pep 1 MPKWSRIRRC SVLSLMFSAA VSRLTWCAPP SNAAFRVRLK SSDGIASASA 51VCPAAGSMPS ETVSHKSDSS RNTSASRRNV SPKCPFGTVC RQDAAKPRRF 101 GGKSHILTGS R*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1575>:

m542.seq 1 ATGCCGAAAT GGTCGCGCAT ACGGCGTTGC AGCGTCCTTT CACTGATGTT 51CAGCGCGTCT GTCAGCCGGT TGACTTGGTG TGCGCCGTCG GCAAACGCGG 101 CATTTAGGGTGCGGCTGAAG TCTTCAGACG GCATAGCGTC TGCTTCCGCC 151 GTTTGCCCCG CCGCCGGCCCGATGCCGTCT GAAACCGTGT CCCACAAGTC 201 CGACAGCAGC CGCAACACGT CCGCCTCGCG.CGCAATGTT TCGCCCAAAT 251 GCCCCTTTGG GACGGCTTTC AGGCAGGATG CCGCCAAGCCGCGCAGGTTC 301 GGGGGCAAAT CCCATATCCT GACCGGTTCG CGGTAAThis corresponds to the amino acid sequence <SEQ ID 1576; ORF 542>:

m542.pep 1 MPKWSRIRRC SVLSLMFSAS VSRLTWCAPS ANAAFRVRLK SSDGIASASA 51VCPAAGPMPS ETVSHKSDSS RNTSASRAMF RPNAPLGRNV SPKCPFGTAF 101 RQDAAKPRRFGGKSHILTGS R*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 542 shows 93.7% identity over a 111 aa overlap with a predicted ORF(ORF 542.ng) from N. gonorrhoeae:

m542/g542 10        20        30        40        50        60 m542.pepMPKWSRIRRCSVLSLMFSASVSRLTWCAPSANAAFRVRLKSSDGIASASAVCPAAGPMPS|||||||||||||||||||:||||||||| :||||||||||||||||||||||||| ||| g542MPKWSRIRRCSVLSLMFSAAVSRLTWCAPPSNAAFRVRLKSSDGIASASAVCPAAGSMPS        10        20        30        40        50        60        70        80        90       100       110 m542.pepETVSHKSDSSRNTSASXRNVSPKCPFGTAFRQDAAKPRRFGGKSHILTGSRX|||||||||||||||| |||||||||||: |||||||||||||||||||||| g542ETVSHKSDSSRNTSASRRNVSPKCPFGTVCRQDAAKPRRFGGKSHILTGSRX        70        80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1577>:

a542.seq 1 ATGCCGAAAT GGTCGCGCAT ACGGCGTTGC AGCGTCCTTT CGCTGATGTT 51CAGCGTGTCT GCCAGCCGGT TGACTTGATG TGCGCCGCCG GCAAACGCGG 101 CATTCAGGATGCGGCTGAAG TCTTCAGACG GCATAGCGTC TGCTTCCGCC 151 GTTTGCCCCG CCGCCGGCCCGATGCCGTCT GAAACCGTGT CCCACAAGTC 201 CGACAGCAGC CGCAACACGT CCGCCTCGCGGCGCAATGTT TCGCCCAAAT 251 GCCCCTTTGG GACGGCTTTC AGGCAGGATG CCGCCAAGCCGCGCAGGTTC 301 GGGGGCAAAT CCCATATCCT GACCGGTTCG CGGTAAThis corresponds to the amino acid sequence <SEQ ID 1578; ORF 542.a>:

a542.pep 1 MPKWSRIRRC SVLSLMFSVS ASRLT*CAPP ANAAFRMRLK SSDGIASASA 51VCPAAGPMPS ETVSHKSDSS RNTSASRRNV SPKCPFGTAF RQDAAKPRRF 101 GGKSHILTGS R*m542/a542 94.6% identity in 111 aa overlap        10        20        30        40        50        60 m542.pepMPKWSRIRRCSVLSLMFSASVSRLTWCAPSANAAFRVRLKSSDGIASASAVCPAAGPMPS||||||||||||||||||:|:|||| ||| ||||||:||||||||||||||||||||||| a542MPKWSRIRRCSVLSLMFSVSASRLTXCAPPANAAFRMRLKSSDGIASASAVCPAAGPMPS        10        20        30        40        50        60        70        80        90       100       110 m542.pepETVSHKSDSSRNTSASXRNVSPKCPFGTAFRQDAAKPRRFGGKSHILTGSRX|||||||||||||||| ||||||||||||||||||||||||||||||||||| a542ETVSHKSDSSRNTSASRRNVSPKCPFGTAFRQDAAKPRRFGGKSHILTGSRX        70        80        90       100       110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1579>:

g543.seq 1 atggtttgtc ggttatttgc cgccgttttt ggctttcaac tcggcaatca 51gcccgtcgat gcctttggct ttgatgattt cgccgaattg gttgcggtac 101 acggtaaccaggctcgtgcc ttcgatggcg acgttgtagg tacggtattt 151 gccgccgctt tggtaggtggtaaagtccat attgacgggc ttctgaccgg 201 ggatgccgac ttcggcacgg acgacgatttccttgccgcc cttattgacg 251 atgggattgt ctttgacgtt gacggtcgcg tttttgaatttcagcatcgt 301 gccggaatag gtgcggatca gcagggtttg aaattctttg gccaacgctt351 gtttttgcgc gtcggacgcg gtacgccaag ggttgccgac cgccaatgcg 401gtcatacgtt ggaaatcgaa atagggaacc gcataggctt cggcttttgg 451 gcgtgcagaagccgcgtcgc cgcttttgag gatggtcaaa acctgtgtgg 501 cgttttggcg gatttgtcccactgcgtcgg ccggggaggc aaatgccatg 551 ccgatgctca aaataccgat gcccaatgcgctgatgaagg aggatttttt 601 cacgatgtct ttcctgaaaa tggatgtgta tgtttattctgcggcttttt 651 ccgcattgcc gccctcagcg tttttctcgg cgaagctggt catgaattta701 ccgatcaggt tttccagaac cattgcagaa ctggttacgg agatggtgtc 751gccggcagca aggttttccg tatcgccgcc ctgctgcagc ccgatgtact 801 gttcgcccaaaagtcccgaa gtcaggattt gcgcggaaac gtcactgctg 851 aactgatact tgccgtccaaatcaaggcgc accctcgcct gataggattt 901 cgggtcaagc ccgatagcgc cgacgcgcccgaccaatacg cctgcggatt 951 tgacgggggc attgaccttc aaaccgccga tgtcgccgaaatcggcataa 1001 acggcgtaag ttttgtccga accgccgaac gccgcgccgc ccgccacgcg1051 gaaagcgaga aaggcaaccg ccgccgcgcc gatcaagacg aacagtccga 1101cccaaaattc caatatgttc tttttcatta aThis corresponds to the amino acid sequence <SEQ ID 1580; ORF 543.ng>:

g543.pep 1 MVCRLFAAVF GFQLGNQPVD AFGFDDFAEL VAVHGNQARA FDGDVVGTVF 51AAALVGGKVH IDGLLTGDAD FGTDDDFLAA LIDDGIVFDV DGRVFEFQHR 101 AGIGADQQGLKFFGQRLFLR VGRGTPRVAD RQCGHTLEIE IGNRIGFGFW 151 ACRSRVAAFE DGQNLCGVLADLSHCVGRGG KCHADAQNTD AQCADEGGFF 201 HDVFPENGCV CLFCGFFRIA ALSVFLGEAGHEFTDQVFQN HCRTGYGDGV 251 AGSKVFRIAA LLQPDVLFAQ KSRSQDLRGN VTAELILAVQIKAHPRLIGF 301 RVKPDSADAP DQYACGFDGG IDLQTADVAE IGINGVSFVR TAERRAARHA351 ESEKGNRRRA DQDEQSDPKF QYVLFH*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1581>:

m543.seq 1 ATGGTTTGTC GGTTATTTGC CGCCGTTTTT GGCTTTCAAC TCGGCAATCA 51GTCCGTCCAC GCCTTTCGCT TTGATAATTT CGCCGAATTG GTTGCGGTAC 101 ACGGTAACCAGGCTCGCGCC TTCGATGGCG ACGTTGTAGG TACGGTATTT 151 ACCGCCGCTT TGGTAGGTGGTGAAGTCCAT GTTGACGGGT TTTTGCCCGG 201 GTACGCCGAC TTCGGCGCGG ACGATGATTTCTTTGCCGCC TTTATTGACG 251 ATGGGATTGT CTTTGACGTT GACGTTGGCG TTTTTTAATTTCAGCATCGT 301 GCCGGAATAG GTGCGGATCA GCAGGGTTTG AAATTCTTTG GCCAACGCTT351 GTTTTTGCGC GTCGGACGCG GTGCGCCAAG GGTTGCCGAC CGCCAATGCG 401GTCATACGTT GGAAATCGAA ATAGGGAATC GCATAGGCTT CGGCTTTTTG 451 GCGAGCGGTGTTGGCATCGC CGTTTTTTAA GATGCTCAAT ACTTGAGTGG 501 CGTTTTGACG GATTTGGCTTACCGCGTCGG CAGGGGCGGC AAATGCCATG 551 CCGATGCTCA AAATACCGAT GCCCAATGCGCTGATGAGGG AGGATTTTTT 601 CATGATTAAG TGTCCTAGTT TGAATATGAT GGCATACGTTTATTCGGCGG 651 CTTTTTCCGC ATTGCCGCCG TCGGCATTTT TCTCGGCAAA ACTCGTCATG701 AATTTGCCGA TAAGGTTTTC CAGAACCATT GCAGAACTGG TTACGGAGAT 751GGTGTCGCCG GCAGCAAGGT TTTCCGTGTC GCCGCCCTGC TGCAGCCCGA 801 TGTACTGCTCGCCCAAAAGT CCCGAAGTCA GGATTTGCGC GGAAACGTCG 851 CTGCTGAACT GATACTTGCCGTCCAAATCG AGGCGCACCC TCGCCTGATA 901 GGATTTCGGG TCAAGTCCGA TAGCGCCGACGCGCCCGACC AATACGCCTG 951 CGGATTTGAC GGGGGCATTG ACCTTCAAAC CGCCGATGTCGCCGAAATCG 1001 GCATAAACGG CGTAAGTTTT GTCCGAACCG CCGAACGCCG CACCGCCGGC1051 CACGCGGAAA GCGAGAAAGG CAACCGCCGC CGCGCCAATC AGGACGAACA 1101GTCCGACCCA AAATTCCAAT ATGTTCTTCT TCATTAAThis corresponds to the amino acid sequence <SEQ ID 1582; ORF 543>:

m543.pep 1 MVCRLFAAVF GFQLGNQSVH AFRFDNFAEL VAVHGNQARA FDGDVVGTVF 51TAALVGGEVH VDGFLPGYAD FGADDDFFAA FIDDGIVFDV DVGVFXFQHR 101 AGIGADQQGLKFFGQRLFLR VGRGAPRVAD RQCGHTLEIE IGNRIGFGFL 151 ASGVGIAVFX DAQYLSGVLTDLAYRVGRGG KCHADAQNTD AQCADEGGFF 201 HDXVSXFEYD GIRLFGGFFR IAAVGIFLGKTRHEFADKVF QNHCRTGYGD 251 GVAGSKVFRV AALLQPDVLL AQKSRSQDLR GNVAAELILAVQIEAHPRLI 301 GFRVKSDSAD APDQYACGFD GGIDLQTADV AEIGINGVSF VRTAERRTAG351 HAESEKGNRR RANQDEQSDP KFQYVLLH*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 543 shows 84.2% identity over a 379 aa overlap with a predicted ORF(ORF 543.ng) from N. gonorrhoeae:

m543/g543           10        20        30        40        50        60m543.pep   MVCRLFAAVFGFQLGNQSVHAFRFDNFAELVAVHGNQARAFDGDVVGTVFTAALVGGEVH  ||||||||||||||||| | || ||:||||||||||||||||||||||||:||||||:|| g543  MVCRLFAAVFGFQLGNQPVDAFGFDDFAELVAVHGNQARAFDGDVVGTVFAAALVGGKVH          10        20        30        40        50        60          70        80        90       100       110       120 m543.pep  VDGFLPGYADFGADDDFFAAFIDDGIVFDVDVGVFXFQHRAGIGADQQGLKFFGQRLFLR  :||:| | ||||:||||:||:||||||||||  || |||||||||||||||||||||||| g543  IDGLLTGDADFGTDDDFLAALIDDGIVFDVDGRVFEFQHRAGIGADQQGLKFFGQRLFLR          70        80        90       100       110       120         130       140       150       160       170       180 m543.pep  VGRGAPRVADRQCGHTLEIEIGNRIGFGFLASGVGIAVFXDAQYLSGVLTDLAYRVGRGG  ||||:|||||||||||||||||||||||| |    :|:| |:| | |||:||:: ||||| g543  VGRGTPRVADRQCGHTLEIEIGNRIGFGFWACRSRVAAFEDGQNLCGVLADLSHCVGRGG         130       140       150       160       170       180         190       200       210        220       230      239 m543.pep  KCHADAQNTDAQCADEGGFFHDXVSXFEYDG-IRLFGGFFRIAAVGIFLGKTRHEFADKV  ||||||||||||||||||||||    |  :| : || |||||||:::|||:: |||:|:| g543  KCHADAQNTDAQCADEGGFFHDV---FPENGCVCLFCGFFRIAALSVFLGEAGHEFTDQV         190       200       210          220       230240       250       260       270       280       290      299 m543.pep  FQNHCRTGYGDGVAGSKVFRVAALLQPDVLLAQKSRSQDLRGNVAAELILAVQIEAHPRL  ||||||||||||||||||||:|||||||||:|||||||||||||:|||||||||:||||| g543  FQNHCRTGYGDGVAGSKVFRIAALLQPDVLFAQKSRSQDLRGNVTAELILAVQIKAHPRL  240       250       260       270       280       290300       310       320       330       340       350      359 m543.pep  IGFRVKSDSADAPDQYACGFDGGIDLQTADVAEIGINGVSFVRTAERRTAGHAESEKGNR  |||||| |||||||||||||||||||||||||||||||||||||||||:| ||||||||| g543  IGFRVKPDSADAPDQYACGFDGGIDLQTADVAEIGINGVSFVRTAERRAARHAESEKGNR  300       310       320       330       340       350360       370      379 m543.pep   RRANQDEQSDPKFQYVLLHX  |||:|||||||||||||:|| g543   RRADQDEQSDPKFQYVLFHX   360       370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1583>:

a543.seq 1 ATGGCTTATG GATTACTTGC TGCCGTTTNT AGCCTTCAAC TCGNCAATCA 51GTCCGTCCAC GCCTTTCGCT TTGATAATTT CGCCGAATTG GTTGCGGTAC 101 ACGGTAACCAGGCTCGCGCC TTCGATGGCG ACGTTGTAGG TACGGTATTT 151 ACCGCCGCTT TGGTAGGTGGTGAAGTCCAT GTTGACGGGT TTTTGCCCGG 201 NNACGCCGAC TTCGGCGCGG ACGATGATTTCTTTGCCGCC TTTATTGACG 251 ATNGGATTGT CTTTGACGTT GACGTTGGCG TTTTTTAATTTCAGCATCGT 301 GCCGGAATAG GTGCGGATCA GCAGGGTTTG AAATTCTTTG GCCAACGCTT351 GTTTTTGCGC GTCGGACGCG GTGCGCCAAG GGTTGCCGAC CGCCAATGCG 401GTCATACGTT GGAAATCGAA ATAGGGAATC GCATAGGCTT CGGCTTTTTG 451 GCGGGCGGTGTTGGCATCAC CGCTTTTTAA GATGCTCAAT ACTTGAGTGG 501 CGTTTTGACG GATTTGGTTTACCGCGTCGG CAGGGGCGGC AAATGCCATG 551 CCGATGCTCA AAATACCGAT GCCCAATGCGCTGATGAAGG AGGATTTTTT 601 CATGATTAAG TGTCCTAGTT TGAATATGAT GGCATACGTTTATTCGGCGG 651 CTTTTTCCGC ATTGCCGCCG TCGGCATTTT TCTCGGCAAA ACTCGTCATG701 AATTTGCCGA TAAGGTTTTC CAGAACCATT GCAGAACTGG TTACGGAGAT 751GGTGTCGCCG GCAGCAAGGT TTTCCGTGTC GCCGCCCTGC TGCAGCCCGA 801 TGTACTGCTCGCCCAAAAGT CCCGAAGTCA GGATTTGCGC GGAAACGTCG 851 CTGCTGAACT GATACTTGCCGTCCAAATCG AGGCGCACCC TCGCCTGATA 901 GGATTTCGGG TCAAGTCCGA TAGCGCCGACGCGCCCGACC AATACGCCTG 951 CGGATTTGAC GGGGGCATTG ACCTTCAAAC CGCCGATGTCGCCGAAATCG 1001 GCATAAACGG CGTAAGTTTT GTCCGAACCG CCGAACGCCG CACCGCCGGC1051 CACGCGGAAA GCGAGAAAGG CAACCGCCGC CGCGCCAATC AGGACGAACA 1101GTCCGACCCA AAATTCCAAT ATGTTCTTTT TCATTAAThis corresponds to the amino acid sequence <SEQ ID 1584; ORF 543.a>:

a543.pep 1 MAYGLLAAVX SLQLXNQSVH AFRFDNFAEL VAVHGNQARA FDGDVVGTVF 51TAALVGGEVH VDGFLPGXAD FGADDDFFAA FIDDXIVFDV DVGVF*FQHR 101 AGIGADQQGLKFFGQRLFLR VGRGAPRVAD RQCGHTLEIE IGNRIGFGFL 151 AGGVGITAF* DAQYLSGVLTDLVYRVGRGG KCHADAQNTD AQCADEGGFF 201 HD*VS*FEYD GIRLFGGFFR IAAVGIFLGKTRHEFADKVF QNHCRTGYGD 251 GVAGSKVFRV AALLQPDVLL AQKSRSQDLR GNVAAELILAVQIEAHPRLI 301 GFRVKSDSAD APDQYACGFD GGIDLQTADV AEIGINGVSF VRTAERRTAG351 HAESEKGNRR RANQDEQSDP KFQYVLFH* m543/a543 96.0% identity in 378 aaoverlap         10        20        30        40        50        60m543.pep MVCRLFAAVFGFQLGNQSVHAFRFDNFAELVAVHGNQARAFDGDVVGTVFTAALVGGEVH|:  |:||| ::|| ||||||||||||||||||||||||||||||||||||||||||||| a543MAYGLLAAVXSLQLXNQSVHAFRFDNFAELVAVHGNQARAFDGDVVGTVFTAALVGGEVH        10        20        30        40        50        60        70        80        90       100       110       120 m543.pepVDGFLPGYADFGADDDFFAAFIDDGIVFDVDVGVFXFQHRAGIGADQQGLKFFGQRLFLR||||||| |||||||||||||||| ||||||||||||||||||||||||||||||||||| a543VDGFLPGXADFGADDDFFAAFIDDXIVFDVDVGVFXFQHRAGIGADQQGLKFFGQRLFLR        70        80        90       100       110       120       130       140       150       160       170       180 m543.pepVGRGAPRVADRQCGHTLEIEIGNRIGFGFLASGVGIAVFXDAQYLSGVLTDLAYRVGRGG|||||||||||||||||||||||||||||||:||||::||||||||||||||:||||||| a543VGRGAPRVADRQCGHTLEIEIGNRIGFGFLAGGVGITAFXDAQYLSGVLTDLVYRVGRGG       130       140       150       160       170       180       190       200       210       220       230       240 m543.pepKCHADAQNTDAQCADEGGFFHDXVSXFEYDGIRLFGGFFRIAAVGIFLGKTRHEFADKVF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a543KCHADAQNTDAQCADEGGFFHDXVSXFEYDGIRLFGGFFRIAAVGIFLGKTRHEFADKVF       190       200       210       220       230       240       250       260       270       280       290       300 m543.pepQNHCRTGYGDGVAGSKVFRVAALLQPDVLLAQKSRSQDLRGNVAAELILAVQIEAHPRLI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a543QNHCRTGYGDGVAGSKVFRVAALLQPDVLLAQKSRSQDLRGNVAAELILAVQIEAHPRLI       250       260       270       280       290       300       310       320       330       340       350       360 m543.pepGFRVKSDSADAPDQYACGFDGGIDLQTADVAEIGINGVSFVRTAERRTAGHAESEKGNRR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a543GFRVKSDSADAPDQYACGFDGGIDLQTADVAEIGINGVSFVRTAERRTAGHAESEKGNRR       310       320       330       340       350       360       370      379 m543.pep RANQDEQSDPKFQYVLLHX ||||||||||||||||:||a543 RANQDEQSDPKFQYVLFHX        370The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1585>:

g544.seq 1 atgaaaaaaa tactcaccgc cgccgccgtc gcactgatcg gcatcctcct 51cgccaccgtc ctcatccccg acagtaaaac cgcgcccgcc ttctccctgc 101 ccgacctgcacggaaaaacc gtttccaacg ccgacctgca aggcaaagtc 151 accctgatta atttttggtttccctcctgt ccgggttgtg tgagcgaaat 201 gcccaaagtc accaaaacgg caaacgactacaaaaataaa gatttccaag 251 tcctcgccgt tgcccagccc atcgatccga tagaaagcgtccgccaatac 301 gtcaaagact acggactgcc gtttaccgtc atttatgatg cggacaaagc351 cgtcggacag gcattcggca cacaggttta tccgacttcc gtccttatcg 401gcaaaaaagg cgaaatcctc aaaacttatg tcggcgaacc cgatttcggc 451 aaactctaccaagaaatcga taccgcgctg gcgcaatagThis corresponds to the amino acid sequence <SEQ ID 1586; ORF 544.ng>:

g544.pep 1 MKKILTAAAV ALIGILLATV LIPDSKTAPA FSLPDLHGKT VSNADLQGKV 51TLINFWFPSC PGCVSEMPKV TKTANDYKNK DFQVLAVAQP IDPIESVRQY 101 VKDYGLPFTVIYDADKAVGQ AFGTQVYPTS VLIGKKGEIL KTYVGEPDFG 151 KLYQEIDTAL AQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1587>:

m544.seq 1 ATGAwAAAAA TACTCACCGC CGCCGTCGTC GCACTGATCG GCATCCTCCT 51TGCCATCGTC CTCmTCCCCG ACAGCAAAAC CGCGCCCGCC TTCTCCmTGC 101 CCGACCTGCACGGAAAAACC GTTTCCAACG CCGACCTGCA AGGCAAAGTA 151 ACCCTGATTA ATTTTTGGTTTCCCTCCTGT CCGGGTTGTG TGAGCGAwAT 201 GCCCAAAATC ATTAAAACGG CAAATGACTATAAAAwCAAA AACTTCCAAG 251 TACTTGCCGT CGCCCAGCCC ATCGATCCGA TAGAAAGCGTCCGCCAATAT 301 GTCAAAGACT ACGGTTTGCC GTTTACCGTC ATGTATGATG CGGACAAAGC351 TGTCGGACAG GCGTTCGGCA CACAGGTTTA TCCGACTTCC GTCCTTATCG 401GCAAATAAGG CGAAATCTTC AAAACCTACG TCGGCGAACC CGATTTCGGC 451 AAACTCTACCAAGAAATCGA TACGCGCGTG GCGCAATAGThis corresponds to the amino acid sequence <SEQ ID 1588; ORF 544>:

m544.pep 1 MXKILTAAVV ALIGILLAIV LXPDSKTAPA FSXPDLHGKT VSNADLQGKV 51TLINFWFPSC PGCVSXMPKI IKTANDYKXK NFQVLAVAQP IDPIESVRQY 101 VKDYGLPFTVMYDADKAVGQ AFGTQVYPTS VLIGK*GEIF KTYVGEPDFG 151 KLYQEIDTRV AQ*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 544 shows 90.7% identity over a 162 aa overlap with a predicted ORF(ORF 544.ng) from N. gonorrhoeae:

m544/g544         10        20        30        40        50        60m544.pep MXKILTAAVVALIGILLAIVLXPDSKTAPAFSXPDLHGKTVSNADLQGKVTLINFWFPSC| ||||||:||||||||| || |||||||||| ||||||||||||||||||||||||||| g544MKKILTAAAVALIGILLATVLIPDSKTAPAFSLPDLHGKTVSNADLQGKVTLINFWFPSC        10        20        30        40        50        60        70        80        90       100       110       120 m544.pepPGCVSXMPKIIKTANDYKXKNFQVLAVAQPIDPIESVRQYVKDYGLPFTVMYDADKAVGQ ||||| |||:||||||| |:|||||||||||||||||||||||||||||:||||||||| g544PGCVSEMPKVTKTANDYKNKDFQVLAVAQPIDPIESVRQYVKDYGLPFTVIYDADKAVGQ        70        80        90       100       110       120       130       140       150       160 m544.pepAFGTQVYPTSVLIGKXGEIFKTYVGEPDFGKLYQEIDTRVAQX||||||||||||||| |||:|||||||||||||||||| :||| g544AFGTQVYPTSVLIGKKGEILKTYVGEPDFGKLYQEIDTALAQX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1589>:

a544.seq 1 ATGAAAAAAA TACTCACCGC CGCCGTCGTC GCACTGATCG GCATCCTCCT 51TGCCATCGTC CTCATCCCCG ACAGCAAAAC CGCGCCCGCT TTCTCCCTGT 101 CCGANCTGCACGGAAAAANC GTTTNCAACG CCGACCTGCA AGGCNAAGTT 151 ANCCTGATTA ANTTTTGGTTTCCCTCCTGT CCGGGTTGTG TGAGCGAAAT 201 GNCCANAATC ATTAAAACGG CAAATGACTATAAAAACAAA AACTTCCAAG 251 TCCTTGCCGT CGCCCAGCCC ATCGATCCGA TAGAAAGCGTCCGCCAATAT 301 GTCAAAGACT ACGGTTTGCC GTTTACCGTC ATGTATGATG CGGACAAAGC351 TGTCGGACAG GCGTTCGGCA CACAGGTTTA TCCGACTTCC GTCCTTATCG 401GCAAAAAAGG CGAAATCCTC AAAACTTATG TCGGCGAACC CGATTTCGGC 451 AAACTCTACCAAGAAATCGA TACCGCGCTG GCACAATAGThis corresponds to the amino acid sequence <SEQ ID 1590; ORF 544.a>:

a544.pep 1 MKKILTAAVV ALIGILLAIV LIPDSKTAPA FSLSXLHGKX VXNADLQGXV 51XLIXFWFPSC PGCVSEMXXI IKTANDYKNK NFQVLAVAQP IDPIESVRQY 101 VKDYGLPFTVMYDADKAVGQ AFGTQVYPTS VLIGKKGEIL KTYVGEPDFG 151 KLYQEIDTAL AQ* m544/a54488.9% identity in 162 aa overlap        10        20        30        40        50        60 m544.pepMXKILTAAVVALIGILLAIVLXPDSKTAPAFSXPDLHGKTVSNADLQGKVTLINFWFPSC| ||||||||||||||||||| ||||||||||   ||||:| |||||| |:|| |||||| a544MKKILTAAVVALIGILLAIVLIPDSKTAPAFSLSXLHGKXVXNADLQGXVXLIXFWFPSC        10        20        30        40        50        60        70        80        90       100       110       120 m544.pepPGCVSXMPKIIKTANDYKXKNFQVLAVAQPIDPIESVRQYVKDYGLPFTVMYDADKAVGQ||||| |  ||||||||| ||||||||||||||||||||||||||||||||||||||||| a544PGCVSEMXXIIKTANDYKNKNFQVLAVAQPIDPIESVRQYVKDYGLPFTVMYDADKAVGQ        70        80        90       100       110       120       130       140       150       160 m544.pepAFGTQVYPTSVLIGKXGEIFKTYVGEPDFGKLYQEIDTRVAQX||||||||||||||| |||:|||||||||||||||||| :||| a544AFGTQVYPTSVLIGKKGEILKTYVGEPDFGKLYQEIDTALAQX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1591>:

g547.seq 1 atgttcgtag ataacggatt taataaaacg gtagcgagtt ttgcccaaat 51cgtcgaaact ttcgacgtat tcttctttag gaacgattgc gcctttttta 101 cgcagatgaaacagcggtgc ggttgggtct gctcgttggt atatctcgtt 151 gatatattta caagatgcggcttcgagatt ccgaaccgct cctttaaaga 201 gcttgggctt ttgatacaga taagtctgtcggaacgtttt aggactaatg 251 ccgaagtcga gatggatgcc cattacttcc ccttactcagaaaatattta 301 aaatttataa tgttacatat agttacaaat attagagttt tttgtgtgtg351 cgtcaaggaa ttgttgacaa ttttagttaa aaatttgtct ccaaacggaa 401aaaagcggtt tgttttttgt tgttaaThis corresponds to the amino acid sequence <SEQ ID 1592; ORF 547.ng>:

g547.pep 1 MFVDNGFNKT VASFAQIVET FDVFFFRNDC AFFTQMKQRC GWVCSLVYLV 51DIFTRCGFEI PNRSFKELGL LIQISLSERF RTNAEVEMDA HYFPLLRKYL 101KFIMLHIVTN IRVFCVCVKE LLTILVKNLS PNGKKRFVFC C*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1593>:

m547.seq 1 ATGTTCGTAG ATAACGGATT TAATAAAACG GTAGCGAGTT TTGCCCAAAT 51CGTCGAAACT TTCGACGTAT TCTTCTTTAG GAACGATTGC GCCTTTTTTA 101 CGCAGATGAAACAGCGGTGC GGTTGGGTCT GCTCGTTGGT ATATCTCGTT 151 GATATCTTTC CAAGATGCGGATTCGAGATT CCGAACCGCT CCTTTAAAGA 201 GCTTGGGCTT TTGATACAGA TAAGTCTGTCGGAACGTTTT AGGACTAATG 251 CCGAAGTCGA GATGGATGCT CATTACTTCC CCTTACTCAGAAAATATTTA 301 AAATTTATAA TGTTACATAT ATTTACAAAT ATTAAAGTTT TTTwTTGTGT351 GTGCGTCAAG GAATTGTTGA CAATTTTAGT TAAAAATTTG TCTCCAAACG 401GAAAAAAGCG GTTTGTTTTT TGTTGTTAAThis corresponds to the amino acid sequence <SEQ ID 1594; ORF 547>:

m547.pep 1 MFVDNGFNKT VASFAQIVET FDVFFFRNDC AFFTQMKQRC GWVCSLVYLV 51DIFPRCGFEI PNRSFKELGL LIQISLSERF RTNAEVEMDA HYFPLLRKYL 101KFIMLHIFTN IKVFXCVCVK ELLTILVKNL SPNGKKRFVF CC*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 547 shows 97.2% identity over a 142 aa overlap with a predicted ORF(ORF 547.ng) from N. gonorrhoeae:

m547/g547           10        20        30        40        50        60m547.pep   MFVDNGFNKTVASFAQIVETFDVFFFRNDCAFFTQMKQRCGWVCSLVYLVDIFPRCGFEI  ||||||||||||||||||||||||||||||||||||||||||||||||||||| |||||| g547  MFVDNGFNKTVASFAQIVETFDVFFFRNDCAFFTQMKQRCGWVCSLVYLVDIFIRCGFEI          10        20        30        40        50        60          70        80        90       100       110       120 m547.pep  PNRSFKELGLLIQISLSERFRTNAEVEMDAHYFPLLRKYLKFIMLHIFTNIKVFXCVCVK  ||||||||||||||||||||||||||||||||||||||||||||||| |||:|| ||||| g547  PNRSFKELGLLIQISLSERFRTNAEVEMDAHYFPLLRKYLKFIMLHIVTNIRVF-CVCVK          70        80        90       100       110         130       140 m547.pep   ELLTILVKNLSPNGKKRFVFCCX  ||||||||||||||||||||||| g547   ELLTILVKNLSPNGKKRFVFCCX120       130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1595>:

a547.seq 1 ATGTTCGTAG ATAACGGATT TAATAAAACG GTAGCGAGTT TTGCCCAAAT 51CGTCGAAACT TTCGACGTAT TCTTCTTTAG GAACAATTGC ACCTTTTTTA 101 CGCAGATGAAACAGCGGTGC GGTTGGGTCT GCTCGTTGGT ATATCTCGTT 151 GATATCTTTC CAAGATGCGGCTTCGAGATT CCGAACCGCT CCTTTAAAGA 201 GCTTGGGCTT TTGATACAGA TAAGTCTGTCGGAACGTTTT AGGACTAATG 251 CCGAAGTCGA GATAGATGCT CATTACTTCC CCTTACTCAGAAAATATTTA 301 AAATTTATAA TGTTACATAT ATTTACAAAT ATTAAAGTTT TTTT.TGTGT351 GTGCGTCAAG GAATTGTTGA CAATTTTAGT TThis corresponds to the amino acid sequence <SEQ ID 1596; ORF 547.a>:

a547.pep 1 MFVDNGFNKT VASFAQIVET FDVFFFRNNC TFFTQMKQRC GWVCSLVYLV 51DIFPRCGFEI PNRSFKELGL LIQISLSERF RTNAEVEIDA HYFPLLRKYL 101KFIMLHIFTN IKVFXCVCVK ELLTILV m547/a547 97.6% identity in 127 aa overlap        10        20        30        40        50        60 m547.pepMFVDNGFNKTVASFAQIVETFDVFFFRNDCAFFTQMKQRCGWVCSLVYLVDIFPRCGFEI||||||||||||||||||||||||||||:|:||||||||||||||||||||||||||||| a547MFVDNGFNKTVASFAQIVETFDVFFFRNNCIFFTQMKQRCGWVCSLVYLVDIFPRCGFEI        10        20        30        40        50        60        70        80        90       100       110       120 m547.pepPNRSFKELGLLIQISLSERFRTNAEVEMDAHYFPLLRKYLKFIMLHIFTNIKVFXCVCVK|||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||| a547PNRSFKELGLLIQISLSERFRINAEVEIDAHYFPLLRKYLKFIMLHIFTNIKVFXCVCVK        70        80        90       100       110       120       130       140 m547.pep ELLTILVKNLSPNGKKRFVFCCX ||||||| a547ELLTILVThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1597>:

g548.seq 1 atgttttccg taccgcgttc ctttttgccg ggcgttttcg tacttgccgc 51gcttgccgcc tgcaaacctc aagacaacag tgcggcgcaa gccgcttctt 101 caagtgcatccgcgccggct gcggaaaatg cggcaaagcc gcaaacgcgc 151 ggtacggata tgcgtaaggaagacatcggc ggcgatttca cactgaccga 201 cggcgaaggc aagcctttca gcctgagcgatttgaaaggc aaggtcgtga 251 ttctgtcttt cggctttacg cactgtcccg atgtctgcccgacagggctt 301 ttgacgtaca gcgacacttt gaagcagttg ggcgggcagg ctaaggacgt351 gaaagtggtg ttcgtcagca tcgatccgga acgcgacacg cctgaaatca 401tcggcaagta tgccaaacag ttcaatccgg actttatcgg tctgacggca 451 acgggcggccaaaacctgcc ggtcatcaag cagcaatacc gcgtggtttc 501 tgccaaaatc aatcaaaaagacgacagcga aaactatttg gtcgaccact 551 cttccggtgc gtatcttatc gataaaaacggtgaggttgc cattttctcg 601 ccttacggaa gcgagccgga aacgattgct gccgatgtaaggaccctgct 651 ctgaThis corresponds to the amino acid sequence <SEQ ID 1598; ORF 548. ng>:

g548.pep 1 MFSVPRSFLP GVFVLAALAA CKPQDNSAAQ AASSSASAPA AENAAKPQTR 51GTDMRKEDIG GDFTLTDGEG KPFSLSDLKG KVVILSFGFT HCPDVCPTGL 101 LTYSDTLKQLGGQAKDVKVV FVSIDPERDT PEIIGKYAKQ FNPDFIGLTA 151 TGGQNLPVIK QQYRVVSAKINQKDDSENYL VDHSSGAYLI DKNGEVAIFS 201 PYGSEPETIA ADVRTLL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1599>:

m548.seq 1 ATGTTTTCCG TACCGCGTTC CTTTTTGCCG GGCGTTTTCG TACTTGCCGC 51GCTTGCCGCC TGCAAACCTC AAGACAACAG TGCGGCGCAA GTCGCTTCTT 101 CAAGTGCATCCGCGTCGGCT GCGGAAAATG CGGCAAAGCA AnACACGCGC 151 GGTACGGATA TGCGTAAGGAAGACATCGGC GGCGATTTCA CGCTGACCGA 201 CGGCGAAGGC AAGCCTTTCA ACCTGAGCGATTTGAAAGGC AAGGTCGTGA 251 TTCTGTCTTT CGGCTTTACG CACTGTCCCG ATGTCTGCCCGACAGAGCTT 301 TTGACGTACA GCGACACGTT GAAGCAGTTG GGCGGGCAGG CTAAGGACGT351 GAAAGTGGTG TTCGTCAGCA TCGATCCGGA ACGCGACACG CCTGAAATCA 401TCGGCAAGTA TGCCAAACAG TTCAATCCGG ACTTTATCGs TCTGACGGCA 451 ACGGGCGGCCAAAACCTGCC GGTCATCAAG CAGCAATACc GCGTGGTTTC 501 TGCCAAAGTC AATCAAAAmGACGACAGCGA AAACTATTTG GTCGACCACT 551 CTTCCGGTGC GTATCTCATC GACAAAAACGGTGAGGTTGC CATTTTCTCG 601 CCTTACGGAA GCGAGCCGGA AACGATTGCT GCCGATGTAAGGACCCTGCT 651 CTGAThis corresponds to the amino acid sequence <SEQ ID 1600; ORF 548>:

m548.pep 1 MFSVPRSFLP GVFVLAALAA CKPQDNSAAQ VASSSASASA AENAAKQXTR 51GTDMRKEDIG GDFTLTDGEG KPFNLSDLKG KVVILSFGFT HCPDVCPTEL 101 LTYSDTLKQLGGQAKDVKVV FVSIDPERDT PEIIGKYAKQ FNPDFIXLTA 151 TGGQNLPVIK QQYRVVSAKVNQXDDSENYL VDHSSGAYLI DKNGEVAIFS 201 PYGSEPETIA ADVRTLL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 548 shows 95.9% identity over a 217 aa overlap with a predicted ORF(ORF 548.ng) from N. gonorrhoeae:

m548/g548         10        20        30        40        50        60m548.pep MFSVPRSFLPGVFVLAALAACKPQDNSAAQVASSSASASAAENAAKQXTRGTDMRKEDIG||||||||||||||||||||||||||||||:||||||| |||||||  |||||||||||| g548MFSVPRSFLPGVFVLAALAACKPQDNSAAQAASSSASAPAAENAAKPQTRGTDMRKEDIG        10        20        30        40        50        60        70        80        90       100       110       120 m548.pepGDFTLTDGEGKPFNLSDLKGKVVILSFGFTHCPDVCPTELLTYSDTLKQLGGQAKDVKVV|||||||||||||:|||||||||||||||||||||||| ||||||||||||||||||||| g548GDFTLTDGEGKPFSLSDLKGKVVILSFGFTHCPDVCPTGLLTYSDTLKQLGGQAKDVKVV        70        80        90       100       110       120       130       140       150       160       170       180 m548.pepFVSIDPERDTPEIIGKYAKQFNPDFIXLTATGGQNLPVIKQQYRVVSAKVNQXDDSENYL|||||||||||||||||||||||||| ||||||||||||||||||||||:|| ||||||| g548FVSIDPERDTPETIGKYAKQFNPDFIGLTATGGQNLPVIKQQYRVVSAKINQKDDSENYL       130       140       150       160       170       180       190       200       210 m548.pepVDHSSGAYLIDKNGEVAIFSPYGSEPETIAADVRTLLX|||||||||||||||||||||||||||||||||||||| g548VDHSSGAYLIDKNGEVAIFSPYGSEPETIAADVRTLLX        190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1601>:

a548.seq 1 ATGTTTTCCG TACCGCGTTC CTTTTTGCCG GGCGTTTTCG TACTTGCCGC 51GCTTGCCGCC TGCAAACCTC AAGACAACAG TGCGGCGCAA GTCGCTTCTT 101 CAAGTGCATCCGCGTCGGCT GCGGAAAATG CGGCAAAGCC GCAAACGCGC 151 GGTACGGATA TGCGTAAGGAAGACATCGGC GGCGATTTCA CGCTGACCGA 201 CGGCGAAGGC AAGCCTTTCA ACCTGAGCGATTTGAAAGGC AAGGTCGTGA 251 TTCTGTCTTT CGGCTTTACG CACTGTCCCG ATGTCTGCCCGACAGAGCTT 301 TTGACGTACA GCGACACGTT GAAGCAGTTG GGCGGGCAGG CTAAGGACGT351 GAAAGTGGTG TTCGTCAGCA TCGATCCGGA ACGCGACACG CCTGAAATCA 401TCGGCAAGTA TGCCAAACAG TTCAATCCGG ACTTTATCGG TCTGACGGCA 451 ACGGGCGACCAAAACCTGCC GGTCATCAAG CAGCAATACC GCGTGGTTTC 501 TGCCAAAGTC AATCAAAAAGACGACAGCGA AAACTATTTG GTCGACCACT 551 CTTCCGGTGC GTATCTCATC GACAAAAACGGTGAGGTTGC CATTTTCTCG 601 CCTTACGGAA GCGAGCCGGA AACGATTGCT GCCGATGTAAGGACCCTGCT 651 CTGAThis corresponds to the amino acid sequence <SEQ ID 1602; ORF 548.a>:

a548.pep 1 MFSVPRSFLP GVFVLAALAA CKPQDNSAAQ VASSSASASA AENAAKPQTR 51GTDMRKEDIG GDFTLTDGEG KPFNLSDLKG KVVILSFGFT HCPDVCPTEL 101 LTYSDTLKQLGGQAKDVKVV FVSIDPERDT PEIIGKYAKQ FNPDFIGLTA 151 TGDQNLPVIK QQYRVVSAKVNQKDDSENYL VDHSSGAYLI DKNGEVAIFS 201 PYGSEPETIA ADVRTLL* m548/a548 97.7%identity in 217 aa overlap        10        20        30        40        50        60 m548.pepMFSVPRSFLPGVFVLAALAACKPQDNSAAQVASSSASASAAENAAKQXTRGTDMRKEDIG||||||||||||||||||||||||||||||||||||||||||||||  |||||||||||| a548MFSVPRSFLPGVFVLAALAACKPQDNSAAQVASSSASASAAENAAKPQTRGTDMRKEDIG        10        20        30        40        50        60        70        80        90       100       110       120 m548.pepGDFTLTDGEGKPFNLSDLKGKVVILSFGFTHCPDVCPTELLTYSDTLKQLGGQAKDVKVV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a548GDFTLTDGEGKPFNLSDLKGKVVILSFGFTHCPDVCPTELLTYSDTLKQLGGQAKDVKVV        70        80        90       100       110       120       130       140       150       160       170       180 m548.pepFVSIDPERDTPEIIGKYAKQFNPDFIXLTATGGQNLPVIKQQYRVVSAKVNQXDDSENYL|||||||||||||||||||||||||| ||||| ||||||||||||||||||| ||||||| a548FVSIDPERDTPEIIGKYAKQFNPDFIGLTATGDQNLPVIKQQYRVVSAKVNQKDDSENYL       130       140       150       160       170       180       190       200       210 m548.pepVDHSSGAYLIDKNGEVAIFSPYGSEPETIAADVRTLLX|||||||||||||||||||||||||||||||||||||| a548VDHSSGAYLIDKNGEVAIFSPYGSEPETIAADVRTLLX        190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1603>:

g550.seq 1 atgataacgg acaggtttca tctctttcat tttccagtat ctttcattta 51tcaatctgac aacaaaatgc cgcctgaaaa cagttcagac ggcattttaa 101 ccacaaacggcttacagctt ccattcgccc aacttggcag cgtaagcttc 151 caaatctgca atcggacgggttgccacgcc gctttccatc gctgctttgg 201 cggcagccgt agcgacgcga ggcagcaggcgggaatcgaa cggagtagga 251 atcaggtatt ccgcgccgaa ttcgaatttc ttaccgtaagcggcaaccac 301 ttcttcggtt acttcttcca tcgccaaatc tgccaaagca tacacgcagg351 cgcgtttcat ttcttcgttg atggtggttg cgccgacatc caacgcgccc 401cggaagatga acgggaagca caatacgttg ttcacttggt tcgggaagtc 451 ggagcggccggtaccgataa ccacgtccgg acgggtttct ttcgccagcg 501 gcggcaggat ttccggattcgggttggcca tggcgaacac gatgggtttt 551 tcgttcatcg tgttcaacat ttcaggcgtcagcaggtttg cgccggagag 601 gcccaagaag atgtctttgc ctttaaccgc atcggcaagtacgcgccggc 651 cgttgtcttc aacggcgtag aattttttgg attcgtccat gcggtctttg701 tcttcgcggg tttggtaaat cacgcctttg gagttgcaaa cggttacgtt 751ttcacgtttc aagcccaaat ccagcagttg gttcaggcag gcaatcgcgg 801 cggcacctgcgccggagcac accaaagtcg cttcttcgat tttacggccg 851 gtataacgca gggcgttcaatacggcggcg gcggtaatga tggccgtgcc 901 gtgctggtca tcatgaaata cggggattttgcagcgtttg cgtaaThis corresponds to the amino acid sequence <SEQ ID 1604; ORF 550.ng>:

g550.pep 1 MITDRFHLFH FPVSFIYQSD NKMPPENSSD GILTTNGLQL PFAQLGSVSF 51QICNRTGCHA AFHRCFGGSR SDARQQAGIE RSRNQVFRAE FEFLTVSGNH 101 FFGYFFHRQICQSIHAGAFH FFVDGGCADI QRAPEDEREA QYVVHLVREV 151 GAAGTDNHVR TGFFRQRRQDFRIRVGHGEH DGFFVHRVQH FRRQQVCAGE 201 AQEDVFAFNR IGKYAPAVVFNGVEFFGFVH AVFVFAGLVN HAFGVANGYV 251 FTFQAQIQQL VQAGNRGGTC AGAHQSRFFDFTAGITQGVQ YGGGGNDGRA 301 VLVIMKYGDF AAFA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1605>:

m550.seq (partial) 1 ..GACGGCATCG GCAAGCACGC GCTGGCCGTT GTCTTCAATGGCGTAGAACT 51   GTTTGGACTC GTCCATACGG TCTTTGTCTT CGCGGGTTTG GTAAATCACG101   CCTTTGGAGT CGCAAACGGT CACGTTTTCG CGTTTCAAGC CCAAATCCAG 151  CAATTGGwTC AAGCAGGCAA TCGCGGCCGC ACCTGCGCCG GAACACACCA 201  AAGTCGCTTC TTCGATTTTA CGGCCGGTAA AACGCAkGGC GTTCAATACG 251  GCGGCGGCGG TAATGATGGC CGTGCCGTGC TGGTCGTCGT GGAATACGGG 301  GATTTTGCAG CGTTTGCGTA AThis corresponds to the amino acid sequence <SEQ ID 1606; ORF 550>:

m550.pep (partial) 1 ..DGIGKHALAV VFNGVELFGL VHTVFVFAGL VNHAFGVANGHVFAFQAQIQ 51   QLXQAGNRGR TCAGTHQSRF FDFTAGKTXG VQYGGGGNDG RAVLVVVEYG101   DFAAFA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 550 shows % identity over a aa overlap with a predicted ORF (ORF550.ng) from N. gonorrhoeae:

m550/g550                                     10        20        30m550.pep                             DGIGKHALAVVFNGVELFGLVHTVFVFAGLVN                              |||:| ||||||||:||:||:||||||||| g550DGFFVHRVQHFRRQQVCAGEAQEDVFAFNRIGKYAPAVVFNGVEFFGFVHAVFVFAGLVN       190       200       210       220       230       240      40        50        60        70        80        90 m550.pepHAFGVANGHVFAFQAQIQQLXQAGNRGRTCAGTHQSRFFDFTAGKTXGVQYGGGGNDGRA||||||||:||:|||||||| |||||| ||||:||||||||||| | ||||||||||||| g550HAFGVANGYVFTFQAQIQQLVQAGNRGGTCAGAHQSRFFDFTAGITQGVQYGGGGNDGRA       250       260       270       280       290       300      100m550.pep VLVVVEYGDFAAFAX |||:::||||||||| g550 VLVIMKYGDFAAFAX        310The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1607>:

a550.seq 1 CTATATCAAT CTGACAGCAA AATGCCGCCT GAAAACAGTT CAGACGGCAT 51TTTAACCGCA AACGGCTTAC AGCTTCCATT CGCTCAGCTT GGCAGCGTAA 101 GCTTCCAAATCTGCAATCGG ACGGGTTGCC ACGCCGCTTT CCATCGCTGC 151 TTTGGCGGCA GCCGTAGCAACGCGCGGCAG CAGGCGGGAA TCGAACGGAG 201 TCGGAATCAG GTATTCCGCG CCGAATTCAAATTTCTTACC GTAAGCGGCA 251 ACCACTTCTT CGGTTACCTC TTCCATCGCC AAATCCGCCAAAGCATACAC 301 GCAGGCGCGT TTCATTTCTT CGTTGATGGT CGTCGCGCCG ACATCCAACG351 CACCGCGGAA GATGAACGGG AAGCACAATA CATTGTTCAC TTGGTTCGGG 401AAGTCGGAGC GGCCGGTACC GATAACCACG TCCGGACGGG TTTCTTTCGC 451 CAGCGGCGGCAGGATTTCCG GATTCGGGTT GGCCATAGCG AACACGATGG 501 GTTTTTCGTT CATGGTGTTCAGTATTTCAG GCGTCAGCAG GTTCGCGCCG 551 GAGAGGCCCA AGAAGATGTC TTTGCCTTTGACGGCATCGG CAAGCACGCG 601 CTGGCCGTTG TCTTCAATGG CGTAGAACTG TTTGGACTCGTCCATACGGT 651 CTTTGTCTTC GCGGGTTTGG TAAATCACGC CTTTGGAGTC GCAAACGGTC701 ACGTTTTCGC GTTTCAAGCC CAAATCCAGC AATTGGTTCA AGCAGGCAAT 751CGCGGCCGCA CCTGCGCCGG AACACACCAA AGTCGCTTCT TCGATTTTAC 801 GGCCGGTAAAACGCAGGGCG TTCAATACGG CAGCGGCGGT AATGATGGCC 851 GTGCCGTGCT GGTCGTCGTGGAATACGGGG ATTTTGCAGC GTTTGCGTAAThis corresponds to the amino acid sequence <SEQ ID 1608; ORF 550.a>:

a550.pep 1 LYQSDSKMPP ENSSDGILTA NGLQLPFAQL GSVSFQICNR TGCHAAFHRC 51FGGSRSNARQ QAGIERSRNQ VFRAEFKFLT VSGNHFFGYL FHRQIRQSIH 101 AGAFHFFVDGRRADIQRTAE DEREAQYIVH LVREVGAAGT DNHVRTGFFR 151 QRRQDFRIRV GHSEHDGFFVHGVQYFRRQQ VRAGEAQEDV FAFDGIGKHA 201 LAVVFNGVEL FGLVHTVFVF AGLVNHAFGVANGHVFAFQA QIQQLVQAGN 251 RGRTCAGTHQ SRFFDFTAGK TQGVQYGSGG NDGRAVLVVVEYGDFAAFA* m550/a550 97.2% identity in 106 aa overlap                                      10        20        30 m550.pep                              DGIGKHALAVVFNGVELFGLVHTVFVFAGL                              |||||||||||||||||||||||||||||| a550EHDGFFVHGVQYFRRQQVRAGEAQEDVFAFDGIGKHALAVVFNGVELFGLVHTVFVFAGL    170       180       190       200       210       220        40        50        60        70        80        90 m550.pepVNHAFGVANGHVFAFQAQIQQLXQAGNRGRTCAGTHQSRFFDFTAGKTXGVQYGGGGNDG|||||||||||||||||||||| ||||||||||||||||||||||||| |||||:||||| a550VNHAFGVANGHVFAFQAQIQQLVQAGNRGRTCAGTHQSRFFDFTAGKTQGVQYGSGGNDG    230       240       250       260       270       280        100m550.pep RAVLVVVEYGDFAAFAX ||||||||||||||||| a550 RAVLVVVEYGDFAAFAX    290       300The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1609>:

g552.seq 1 atgaagctga aaaccttgtt attgcccttc gccgcactgg cattgtgtgc 51caacgcattt gccgccccgc ccggcgacgc gtcgttggca cgttggctgg 101 atacgcagaatttcgaccgg gatatagaaa aaaatatgat tgaaggcttt 151 aatgccggat ttaaaccgtatgcggacaaa gcccttgccg aaatgccgga 201 agcgaaaaaa gatcaggcgg cagaagcctttaatcgttat cgtgagaatg 251 ttttgaaaga tttgattacg cccgaagtga aacaggctgtccgcaatacc 301 ttattgaaga atgcccgtga aatatacacg caagaagaaa ttgacggcat351 gattgccttt tacggttcgc ctgtcggtca gtccgtcgtt gccaaaaatc 401cgcgcttaat caagaaatcg atgagtgaaa tagcggtatc ttggactgca 451 ttgtcagggaaaatcgcgcg acatcatctg cccgagttta cggaagagtt 501 acggcgcatc atctgcggcggtatagtgga ttaaThis corresponds to the amino acid sequence <SEQ ID 1610; ORF552.ng>:

g552.pep 1 MKLKTLLLPF AALALCANAF AAPPGDASLA RWLDTQNFDR DIEKNMIEGF 51NAGFKPYADK ALAEMPEAKK DQAAEAFNRY RENVLKDLIT PEVKQAVRNT 101 LLKNAREIYTQEEIDGMIAF YGSPVGQSVV AKNPRLIKKS MSEIAVSWTA 151 LSGKIARHHL PEFTEELRRIICGGIVD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1611>:

m552.seq (partial) 1 ..ATTAAACTGA AAACCTTGTT ATTGCCCTTC GCCACGCTGGCATTGTGCAC 51   CAATGCTTTT GCCGCCCCGC CCAGCGACGC GTCGTTGGCG CGTTGGCTGG101   ATACGCAGAA TTTTGACCGG GATATAGAAA AAAATATGAT TGAGGGCTTT 151  AATGCCGGAT TTAAACCGTA TGCGGACAAA GCCCTTGCCG AAATGCCGGA 201  AGCGAAAAAA GATCAGGCGG CAGAAGCCTT TAACCGTTAT CGTGAGAATG 251  TTTTGAAAGA TTTGATTACG CCCGAAGTGA AACAGGCTGT CCGCAATACT 301  TTATTGAAGA ATGCCCGTGA GATATACACG CAAGAAGAAA TTGACGGCAT 351  GATTGCCTTT TACGGTTCGC CTGTCGGTCA GTCCGTCGTT GCCAAAAATC 401  CGCGCTTAAT CAAGAAATCG ATGAGTGAAA TAGCGGTATC TTGGACTGCA 451  TTGTCAGGGA AAATCGCGCA ACATCATCTG CCCGAGTTTA CGGAAGAGTT 501  GCGGCGCATC ATCTGCGGCG GTAAAAATCC CGATGCGGGC TGTAAACAAG 551  CCGGACAGGT TGGGAAAAGG CATCAGAAAT AAThis corresponds to the amino acid sequence <SEQ ID 1612; ORF 552>:

m552.pep (partial) 1 ..IKLKTLLLPF ATLALCTNAF AAPPSDASLA RWLDTQNFDRDIEKNMIEGF 51   NAGFKPYADK ALAEMPEAKK DQAAEAFNRY RENVLKDLIT PEVKQAVRNT101   LLKNAREIYT QEEIDGMIAF YGSPVGQSVV AKNPRLIKKS MSEIAVSWTA 151  LSGKIAQHHL PEFTEELRRI ICGGKNPDAG CKQAGQVGKR HQK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 552 shows 97.1% identity over a 174 aa overlap with a predicted ORF(ORF 552.ng) from N. gonorrhoeae:

m552/g552         10        20        30        40        50        60m552.pep IKLKTLLLPFATLALCTNAFAAPPSDASLARWLDTQNFDRDIEKNMIEGFNAGFKPYADK:||||||||||:||||:|||||||:||||||||||||||||||||||||||||||||||| g552MKLKTLLLPFAALALCANAFAAPPGDASLARWLDTQNFDRDIEKNMIEGFNAGFKPYADK        10        20        30        40        50        60        70        80        90       100       110       120 m552.pepALAEMPEAKKDQAAEAFNRYRENVLKDLITPEVKQAVRNTLLKNAREIYTQEEIDGMIAF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g552ALAEMPEAKKDQAAEAFNRYRENVLKDLITPEVKQAVRNTLLKNAREIYTQEEIDGMIAF        70        80        90       100       110       120       130       140       150       160       170       180 m552.pepYGSPVGQSVVAKNPRLIKKSMSEIAVSWTALSGKIAQHHLPEFTEELRRIICGGKNPDAG||||||||||||||||||||||||||||||||||||:||||||||||||||||| g552YGSPVGQSVVAKNPRLIKKSMSEIAVSWIALSGKIARHHLPEFTEELRRIICGGIVDX       130       140       150       160       170        190 m552.pepCKQAGQVGKRHQKXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1613>:

a552.seq 1 ATTAAACTGA AAACCTTGTT ATTGCCCTTC GCCACGCTGG CATTGTGCAC 51CAATGCTTTT GCCGCCCCGC CCAGCGACGC GTCGTTGGCG CGTTGGCTGG 101 ATACGCAGAATTTTGACCGG GATATAGAAA AAAATATGAT TGAGGGCTTT 151 AATGCCGGAT TTAAACCGTATGCGGACAAA GCCCTTGCCG AAATGCCGGA 201 AGCGAAAAAA GATCAGGCGG CAGAAGCCTTTAACCGTTAT CGTGAGAATG 251 TTTTGAAAGA TTTGATTACG CCCGAAGTGA AACAGGCTGTCCGCAATACT 301 TTATTGAAGA ATGCCCGTGA GATATACACG CAAGAAGAAA TTGACGGCAT351 GATTGCCTTT TACGGTTCGC CTGTCGGTCA GTCCGTCGTT GCCAAAAATC 401CGCGCTTAAT CAAGAAATCG ATGAGTGAAA TAGCGGTATC TTGGACTGCA 451 TTGTCAGGGAAAATCGCGCA ACATCATCTG CCCGAGTTTA CGGAAGAGTT 501 GCGGCGCATC ATCTGCGGCGGTAAAAATCC CGATGCGGGC TGTAAACAAG 551 CCGGACAGGT TGGGAAAAGG CATCAGAAAT AAThis corresponds to the amino acid sequence <SEQ ID 1614; ORF 552.a>:

a552.pep 1 IKLKTLLLPF ATLALCTNAF AAPPSDASLA RWLDTQNFDR DIEKNMIEGF 51NAGFKPYADK ALAEMPEAKK DQAAEAFNRY RENVLKDLIT PEVKQAVRNT 101 LLKNAREIYTQEEIDGMIAF YGSPVGQSVV AKNPRLIKKS MSEIAVSWTA 151 LSGKIAQHHL PEFTEELRRIICGGKNPDAG CKQAGQVGKR HQK* m552/a552 100.0% identity in 193 aa overlap        10        20        30        40        50        60 m552.pepIKLKTLLLPFATLALCTNAFAAPPSDASLARWLDTQNFDRDIEKNMIEGFNAGFKPYADK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a552IKLKILLLPFATLALCTNAFAAPPSDASLARWLDTQNFDRDIEKNMIEGFNAGFKPYADK        10        20        30        40        50        60        70        80        90       100       110       120 m552.pepALAEMPEAKKDQAAEAFNRYRENVLKDLITPEVKQAVRNTLLKNAREIYTQEEIDGMIAF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a552ALAEMPEAKKDQAAEAFNRYRENVLKDLITPEVKQAVRNTLLKNAREIYTQEEIDGMIAF        70        80        90       100       110       120       130       140       150       160       170       180 m552.pepYGSPVGQSVVAKNPRLIKKSMSEIAVSWTALSGKIAQHHLPEFTEELRRIICGGKNPDAG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a552YGSPVGQSVVAKNPRLIKKSMSEIAVSWTALSGKIAQHHLPEFTEELRRIICGGKNPDAG       130       140       150       160       170       180        190m552.pep CKQAGQVGKRHQKX |||||||||||||| a552 CKQAGQVGKRHQKX        190The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1615>:

m552-1.seq 1 TTGAATATTA AACTGAAAAC CTTGTTATTG CCCTTCGCCA CGCTGGCATT 51GTGCACCAAT GCTTTTGCCG CCCCGCCCAG CGACGCGTCG TTGGCGCGTT 101 GGCTGGATACGCAGAATTTT GACCGGGATA TAGAAAAAAA TATGATTGAG 151 GGCTTTAATG CCGGATTTAAACCGTATGCG GACAAAGCCC TTGCCGAAAT 201 GCCGGAAGCG AAAAAAGATC AGGCGGCAGAAGCCTTTAAC CGTTATCGTG 251 AGAATGTTTT GAAAGATTTG ATTACGCCCG AAGTGAAACAGGCTGTCCGC 301 AATACTTTAT TGAAGAATGC CCGTGAGATA TACACGCAAG AAGAAATTGA351 CGGCATGATT GCCTTTTACG GTTCGCCTGT CGGTCAGTCC GTCGTTGCCA 401AAAATCCGCG CTTAATCAAG AAATCGATGA GTGAAATAGC GGTATCTTGG 451 ACTGCATTGTCAGGGAAAAT CGCGCAACAT CATCTGCCCG AGTTTACGGA 501 AGAGTTGCGG CGCATCATCTGCGGCGGTAA AAATCCCGAT GCGGGCTGTA 551 AACAAGCCGG ACAGGTTGGG AAAAGGCATCAGAAATAAThis corresponds to the amino acid sequence <SEQ ID 1616; ORF 552-1>:

m552-1.pep 1 LNIKLKTLLL PFATLALCTN AFAAPPSDAS LARWLDTQNF DRDIEKNMIE 51GFNAGFKPYA DKALAEMPEA KKDQAAEAFN RYRENVLKDL ITPEVKQAVR 101 NTLLKNAREIYTQEEIDGMI AFYGSPVGQS VVAKNPRLIK KSMSEIAVSW 151 TALSGKIAQH HLPEFTEELRRIICGGKNPD AGCKQAGQVG KRHQK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1617>:

a552-1.seq 1 TTGAATATTA AACTGAAAAC CTTGTTATTG CCCTTCGCCA CGCTGGCATT 51GTGCACCAAT GCTTTTGCCG CCCCGCCCAG CGACGCGTCG TTGGCGCGTT 101 GGCTGGATACGCAGAATTTT GACCGGGATA TAGAAAAAAA TATGATTGAG 151 GGCTTTAATG CCGGATTTAAACCGTATGCG GACAAAGCCC TTGCCGAAAT 201 GCCGGAAGCG AAAAAAGATC AGGCGGCAGAAGCCTTTAAC CGTTATCGTG 251 AGAATGTTTT GAAAGATTTG ATTACGCCCG AAGTGAAACAGGCTGTCCGC 301 AATACTTTAT TGAAGAATGC CCGTGAGATA TACACGCAAG AAGAAATTGA351 CGGCATGATT GCCTTTTACG GTTCGCCTGT CGGTCAGTCC GTCGTTGCCA 401AAAATCCGCG CTTAATCAAG AAATCGATGA GTGAAATAGC GGTATCTTGG 451 ACTGCATTGTCAGGGAAAAT CGCGCAACAT CATCTGCCCG AGTTTACGGA 501 AGAGTTGCGG CGCATCATCTGCGGCGGTAA AAATCCCGAT GCGGGCTGTA 551 AACAAGCCGG ACAGGTTGGG AAAAGGCATCAGAAATAAThis corresponds to the amino acid sequence <SEQ ID 1618; ORF 552-1.a>:

a552-1.pep 1 LNIKLKTLLL PFATLALCTN AFAAPPSDAS LARWLDTQNF DRDIEKNMIE 51GFNAGFKPYA DKALAEMPEA KKDQAAEAFN RYRENVLKDL ITPEVKQAVR 101 NTLLKNAREIYTQEEIDGMI AFYGSPVGQS VVAKNPRLIK KSMSEIAVSW 151 TALSGKIAQH HLPEFTEELRRIICGGKNPD AGCKQAGQVG KRHQK* a552-1/m552-1 100.0% identity in 195 aaoverlap         10        20        30        40        50        60a552-1.pep LNIKLKTLLLPFATLALCTNAFAAPPSDASLARWLDTQNFDRDIEKNMIEGFNAGFKPYA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m552-1LNIKLKTLLLPFATLALCTNAFAAPPSDASLARWLDTQNFDRDIEKNMIEGFNAGFKPYA        10        20        30        40        50        60        70        80        90       100       110       120 a552-1.pepDKALAEMPEAKKDQAAEAFNRYRENVLKDLITPEVKQAVRNTLLKNAREIYTQEEIDGMI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m552-1DKALAEMPEAKKDQAAEAFNRYRENVLKDLITPEVKQAVRNTLLKNAREIYTQEEIDGMI        70        80        90       100       110       120       130       140       150       160       170       180 a552-1.pepAFYGSPVGQSVVAKNPRLIKKSMSEIAVSWTALSGKIAQHHLPEFTEELRRIICGGKNPD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m552-1AFYGSPVGQSVVAKNPRLIKKSMSEIAVSWTALSGKIAQHHLPEFTEELRRIICGGKNPD       130       140       150       160       170       180        190a552-1.pep AGCKQAGQVGKRHQKX |||||||||||||||| m552-1 AGCKQAGQVGKRHQKX       190The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1619>:

g553.seq 1 atggattatc tgcaaaacct gtctttgggc ttgacaaaaa agctgcccgt 51tatactgcaa acagaagtag cggagtgtgg cttggcatgt ctagcggctg 101 tggccggattttatggtttc tatacggatt tgcgcgcact gcgttcaaaa 151 tactgtctgt cacttaagggtgagaatttg gcagatattg ttcgttttgc 201 tgatgatatg gggctgacgg gacgggcgttgaggctggat ttagacgaat 251 tgggcagttt gcgcctgccc tgtattctac attgggatttgaatcatttt 301 gtggtgctgg aatcggtatc ttcggacggg gctgccgtca tggatccggc351 ttcgggacga cgcaaagtca agacggagga aatatcgcgc aagtttacgg 401gaattgcttt ggaactgtgg ccaaacacgc gtttcgaggc aggggaagaa 451 aagcaggaaatccgcatcct acccatgttg cgcgggattt ctgggctggg 501 gcggacattg tttcagcttttggctttggc agcagcaatg gaagtgtttg 551 cttttttaca aaacgtcagc ttcaagatcggacgtggtga atcgcttgcg 601 ttaatcggac gatcgggctg cggtaaatcg acacttttggatattttaag 651 cggcaatcta cctcccgaat caggcaaagt catgataaat gggcacgaca701 tttacagctt accgccacct tttattccgc aatttgagtg cgatggtcaa 751ggcaggacga tgttttatag tggattaaat ttaaaccggt agThis corresponds to the amino acid sequence <SEQ ID 1620; ORF 553.ng>:

g553.pep 1 MDYLQNLSLG LTKKLPVILQ TEVAECGLAC LAAVAGFYGF YTDLRALRSK 51YCLSLKGENL ADIVRFADDM GLTGRALRLD LDELGSLRLP CILHWDLNHF 101 VVLESVSSDGAAVMDPASGR RKVKTEEISR KFTGIALELW PNTRFEAGEE 151 KQEIRILPML RGISGLGRTLFQLLALAAAM EVFAFLQNVS FKIGRGESLA 201 LIGRSGCGKS TLLDILSGNL PPESGKVMINGHDIYSLPPP FIPQFECDGQ 251 GRTMFYSGLN LNR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1621>:

m553.seq (partial) 1 ATGGATTATT TATCAAGACT GTCCTTTGGA TTTAACAAAAAGCTACCTGT 51 CATTCTGCAA ACAGAAGTTG CTGAATGTGG TTTAGCATGC CTGACATCCA 101TCTTGTCCTA TTATGGCTTT CACACTGATT TAAGAACGTT ACGCCAAAAA 151 TACACCCTGTCATTAAAGGG CGCAAATCTT GCAGACATCA TGAGATTTGG 201 CAATGAAATG AATTTAACGCCACGAGCTTT GCGTTTAGAG TTAGATGAGC 251 TGTCAAATTT ACAACTACCC TGCATTCTCCATTGGAACTT AAACCATTTT 301 GTTGTACTTT GTTCCATTTC CAAAGACAGT ATCGTCATTATGGACCCTGC 351 TGTCGGTATG CGAAAAATCA AAATGGACGA AGTTTCACAA AAATTCACAG401 GGATTGCCCT AGAATTATTC CCCAATACCC ATTTTGAAGA GAAAAAAGAA 451ACAAAGAAAA TCAAAATATT ATCTCTATTA AGGGGGGG.T CAGGCTTAAA 501 ACGCTCTTTAATTCAAATGC TTATATTAGC TATTTCTTTG GAAGTCTTTG 551 CATTG...This corresponds to the amino acid sequence <SEQ ID 1622; ORF 553>:

m553.pep (partial) 1 MDYLSRLSFG FNKKLPVILQ TEVAECGLAC LTSILSYYGFHTDLRTLRQK 51 YTLSLKGANL ADIMRFGNEM NLTPRALRLE LDELSNLQLP CILHWNLNHF 101VVLCSISKDS IVIMDPAVGM RKIKMDEVSQ KFTGIALELF PNTHFEEKKE 151 TKKIKILSLLRGXSGLKRSL IQMLILAISL EVFAL...Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 553 shows 65.5% identity over a 185 aa overlap with a predicted ORF(ORF 553.ng) from N. gonorrhoeae:

m553/g553         10        20        30        40        50        60g553.pep MDYLQNLSLGLTKKLPVILQTEVAECGLACLAAVAGFYGFYTDLRALRSKYCLSLKGENL||||: ||:|::|||||||||||||||||||::: ::|||:||||:||:|| ||||| || m553MDYLSRLSFGFNKKLPVILQTEVAECGLACLTSILSYYGFHTDLRTLRQKYTLSLKGANL        10        20        30        40        50        60        70        80        90       100       110       120 g553.pepADIVRFADDMGLTGRALRLDLDELGSLRLPCILHWDLNHFVVLESVSSDGAAVMDPASGR|||:||:::|:|| |||||:||||::|:|||||||:||||||| |:|:|: ::|||| | m553ADIMRFGNEMNLTPRALRLELDELSNLQLPCILHWNLNHFVVLCSISKDSIVIMDPAVGM        70        80        90       100       110       120       130       140       150       160       170       180 g553.pepRKVKTEEISRKFTGIALELWPNTRFEAGEEKQEIRILPMLRGISGLGRTLFQLLALAAAM||:| :|:|:|||||||||:|||:||  :| ::|:|| :||| ||| |:|:|:| || :: m553RKIKMDEVSQKFTGIALELFPNTHFEEKKETKKIKILSLLRGXSGLKRSLIQMLILAISL       130       140       150       160       170       180       190       200       210       220       230       240 g553.pepEVFAFLQNVSFKIGRGESLALIGRSGCGKSTLLDILSGNLPPESGKVMINGHDIYSLPPP ||||: m553EVFALThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1623>:

a553.seq 1 ATGCCCCATC TGCAAAACCT GTCTTTGGGC TTAAAGAAAA AGCTGCCTGT 51TATCCTGCAA ACAGAAATAT CAGAATGCGG CTTGGCATGT CTGGCGGCTG 101 TGGCGGGATTTCATGGTTTC CATACGAATT TACGCGCACT GCGTTCAAAA 151 TACThis corresponds to the amino acid sequence <SEQ ID 1624; ORF 553.a>:

a553.pep 1 MPHLQNLSLG LKKKLPVILQ TEISECGLAC LAAVAGFHGF HTNLRALRSK 51 Ym553/a553 62.7% identity in 51 aa overlap        10        20        30        40        50        60 m553.pepMDYLSRLSFGFNKKLPVILQTEVAECGLACLTSILSYYGFHTDLRTLRQKYTLSLKGANL | :|:||:|::||||||||||::|||||||::: :::||||:||:||:|| a553MPHLQNLSLGLKKKLPVILQTEISECGLACLAAVAGFHGFHTNLRALRSKY        10        20        30        40        50        70        80        90       100       110       120 m553.pepADIMRFGNEMNLTPRALRLELDELSNLQLPCILHWNLNHFVVLCSISKDSIVIMDPAVGMThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1625>:

g554.seq.. 1 atgacagcac ataaaatcct gcccgtcctt cttcccatca tcttaggcgt 51ttctcacgca acggctgcat cgcccgcgcc caacagaccg acggtacacg 101 ccgcccccacgctccaaaca cccgaaaccc tcacggcggc acacatcgtt 151 atcgaccttc aaagcaggcagactttatcc gccaaaaaca ccaatacccc 201 tgtcgaaccg gcggcactaa cccaactgatgaccgcatat ttggttttca 251 aaaacatgaa atcgggaaat atccaatctg aagaaaacttaaaaataccc 301 gaatccgcat gggcttcaga aggaagcaga atgtttgtac gtcccggcga351 tacggtcagc accgacaaac tcttaaaagg catgattgcc ctatgcgcaa 401acgatgccgc cctaaccctt gccgaccggc tgggcaacgg ctcgattgaa 451 aattttgtgcaacaaatgaa caaagaagcc cgacgcttgg gcatgaagaa 501 caccgtattc aaaaacccgacaggcttggg tagagaagga caggtttcca 551 ccgccaaaga cctctccctg ctgtctgaagcattgatgcg cgactttccg 601 gaatattacc cgctgttttc catcaaatcg ttcaagtttgaaaacataga 651 acaaaacaac cgcaatatcc ttttatatag ggacaacaat gtaaacggcc701 tgaaagccgg gcacacagaa agcggcggct acaaccttgc cgtgtcatac 751tccggcaacg gcaggcacat ccttgtcatc acactaggtt cggaatcggc 801 ggaaacccgcgcatcggaca acagcaagct gctgaaccgg gcattgcagg 851 ccttcgatac gcccaaaatatatccgaaag gcaaaaccgt tgcccaaatc 901 caaatttccg gaggcagcaa aaaaaccgtccgcgcaggct tcctcaaaga 951 agcctacatc actctgccac ataaagaagc gaaaatggcagaacagattt 1001 tggaaaccat acagccgatt cccgccccgg taaaaaaagg gcagatttta1051 ggaaaaatca aaatcaggca aaacggacat accattgccg aaaaagaaat 1101cgtcgcactg gaaaacgtag aaaaaagaag ccggtggcaa aggctttgga 1151 cgcgtctgacagggcagtaaThis corresponds to the amino acid sequence <SEQ ID 1626; ORF 554.ng>:

g554.pep.. 1 MTAHKILPVL LPIILGVSHA TAASPAPNRP TVHAAPTLQT PETLTAAHIV 51IDLQSRQTLS AKNTNTPVEP AALTQLMTAY LVFKNMKSGN IQSEENLKIP 101 ESAWASEGSRMFVRPGDTVS TDKLLKGMIA LCANDAALTL ADRLGNGSIE 151 NFVQQMNKEA RRLGMKNTVFKNPTGLGREG QVSTAKDLSL LSEALMRDFP 201 EYYPLFSIKS FKFENIEQNN RNILLYRDNNVNGLKAGHTE SGGYNLAVSY 251 SGNGRHILVI TLGSESAETR ASDNSKLLNR ALQAFDTPKIYPKGKTVAQI 301 QISGGSKKTV RAGFLKEAYI TLPHKEAKMA EQILETIQPI PAPVKKGQIL351 GKIKIRQNGH TIAEKEIVAL ENVEKRSRWQ RLWTRLTGQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1627>:

m554.seq.. 1 ATGACAGCAC ATAAAATCCT GCCCGTCCTG CTTTCCATCA TCTTAGGCGT 51TTCTCACGCA ACGGCTGCAT CGCCCGCGCC CAACAGACCG ACGGTACACG 101 CCGCCCCCACGTTCCAAACA CCCGAAACCC TCACAGCGGC ACACATCGTT 151 ATCGACCTTC AAAGCAAACAGATTTTATCC GCCAAAAACA TCAATACCCC 201 TGTTGAACCG GCGGCACTAA CCCAACTGATGACCGCATAT CTGGTTTTCA 251 AAAACATGAA ATCGGGCAAT ATCCAATCTG AAGAAAACTTAAAAATACCC 301 GAATCCGCAT GGGCTTCAGA AGGAAGCAGA ATGTTTGTAC GTCCCGGCGA351 TACGGTCAGC ACCGACAAAC TCTTAAAAGG CATGATTGCA CTATCCGCAA 401ACGATGCCGC CCTAACCCTT GCCGGCCGGC TGGGCAACGG CTCGATTGAA 451 AATTTTGTGCAACAAATGAA CAAAGAAGCC CGACGCTTGG GCATGAAGAA 501 CACTGTATTC AAAAACCCGACAGGCTTGAG TAGAGAAGGA CAGGTTTCCA 551 CCGCCAAAGA CGTCGCACTG CTGTCTGAAGCATTGATGCG CGACTTTCCG 601 GAATATTACC CGCTGTTTTC CATCAAATCT TTCAAATTCAAAAATATAGA 651 ACAAAACAAC CGCAATATCC TTTTATATAG GGACAACAAT GTAAACGGTC701 TGAAAGCCGG ACACACAGAA AGCGGCGGCT ACAACCTTGC CGTGTCATAC 751TCCGGCAACG GCAGGCACAT CCTTGTCATC ACATTGGGTT CGGAATCGGC 801 GGAAACACGCGCATCAGACA ACAGCAAGCT GCTGAACTGG GCATTGCAGG 851 CCTTCGATAC GCCCAAAATATATCCGAAAG GCAAAACCGT TGCCCAAATC 901 CAAATTTCCG GAGGCAGCAA AAAAACCGTCCGCGCAGGCT TCCTCAAAGA 951 AGCCTACATC ACTCTGCCAC ATAAGGAAGC GAAAATGGCAGAACAAATTC 1001 TAGAAACCAT ACAGCCGATT CCCGCCCCAG TAAAAAAAGG GCAAATTTTA1051 GGAAAAATCA AAATCAGACA AAACGGATAC ACCATTGCCG AAAAAGAAAT 1101CGTCGCACTG GAAAATGTAA AAAAAAGAAG CCGGTGGCAA AGGCTTTGGG 1151 CGTGTCTGACAGGGCAGTAAThis corresponds to the amino acid sequence <SEQ ID 1628; ORF 554>:

m554.pep.. 1 MTAHKILPVL LSIILGVSHA TAASPAPNRP TVHAAPTFQT PETLTAAHIV 51IDLQSKQILS AKNINTPVEP AALTQLMTAY LVFKNMKSGN IQSEENLKIP 101 ESAWASEGSRMFVRPGDTVS TDKLLKGMIA LSANDAALTL AGRLGNGSIE 151 NFVQQMNKEA RRLGMKNTVFKNPTGLSREG QVSTAKDLAL LSEALMRDFP 201 EYYPLFSIKS FKFKNIEQNN RNILLYRDNNVNGLKAGHTE SGGYNLAVSY 251 SGNGRHILVI TLGSESAETR ASDNSKLLNW ALQAFDTPKIYPKGKTVAQI 301 QISGGSKKTV RAGFLKEAYI TLPHKEAKMA EQILETIQPI PAPVKKGQIL351 GKIKIRQNGY TIAEKEIVAL ENVKKRSRWQ RLWACLTGQ*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 554 shows 96.1% identity over a 389 aa overlap with a predicted ORF(ORF 554.ng) from N. gonorrhoeae:

m554/g554         10        20        30        40        50        60m554.pep MTAHKILPVLLSIILGVSHATAASPAPNRPTVHAAPTFQTPETLTAAHIVIDLQSKQILS||||||||||| |||||||||||||||||||||||||:|||||||||||||||||:| || g554MTAHKILPVLLPIILGVSHATAASPAPNRPTVHAAPTLQTPETLTAAHIVIDLQSRQTLS        10        20        30        40        50        60        70        80        90       100       110       120 m554.pepAKNINTPVEPAALTQLMTAYLVFKNMKSGNIQSEENLKIPESAWASEGSRMFVRPGDTVS||| |||||||||||||||||||||||||||||||||||||||||||||||||||||||| g554AKNTNTPVEPAALTQLMTAYLVFKNMKSGNIQSEENLKIPESAWASEGSRMFVRPGDTVS        70        80        90       100       110       120       130       140       150       160       170       180 m554.pepTDKLLKGMIALSANDAALTLAGRLGNGSIENFVQQMNKEARRLGMKNTVFKNPTGLSREG||||||||||| ||||||||| ||||||||||||||||||||||||||||||||||:||| g554TDKLLKGMIALCANDAALTLADRLGNGSIENFVQQMNKEARRLGMKNTVFKNPTGLGREG       130       140       150       160       170       180       190       200       210       220       230       240 m554.pepQVSTAKDLALLSEALMRDFPEYYPLFSIKSFKFKNIEQNNRNILLYRDNNVNGLKAGHTE||||||||:||||||||||||||||||||||||:|||||||||||||||||||||||||| g554QVSTAKDLSLLSEALMRDFPEYYPLFSIKSFKFENIEQNNRNILLYRDNNVNGLKAGHTE       190       200       210       220       230       240       250       260       270       280       290       300 m554.pepSGGYNLAVSYSGNGRHILVITLGSESAETRASDNSKLLNWALQAFDTPKIYPKGKTVAQI||||||||||||||||||||||||||||||||||||||| |||||||||||||||||||| g554SGGYNLAVSYSGNGRHILVITLGSESAETRASDNSKLLNRALQAFDTPKIYPKGKTVAQI       250       260       270       280       290       300       310       320       330       340       350       360 m554.pepQISGGSKKTVRAGFLKEAYITLPHKEAKMAEQILETIQPIPAPVKKGQILGKIKIRQNGY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: g554QISGGSKKTVRAGFLKEAYITLPHKEAKMAEQILETIQPIPAPVKKGQILGKIKIRQNGH       310       320       330       340       350       360       370       380       390 m554.pep TIAEKEIVALENVKKRSRWQRLWACLTGQX|||||||||||||:|||||||||: ||||| g554 TIAEKEIVALENVEKRSRWQRLWTRLTGQX       370       380       390The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1629>:

a554.seq 1 ATGACAGCAC ATAAAATCCT GCCCGTCCTG CTTTCCATCA TCTTAGGCGT 51TTCTCACGCA ACGGCTGCAT CGCCCGCGCC CAACAGACCG ACGGCACACG 101 CCGCCCCCACGTTCCAAACA CCCGAAACCC TCACAGCGGC ACACATCGTT 151 ATCGACCTTC AAAGCAAACAGATTTTATCC GCCAAAAACA TCAATACCCC 201 TGTCGAACCG GCGGCACTAA CCCAACTGATGACCGCATAT CTGGTTTTCA 251 AAAACATGAA ATCGGGAAAT ATCCGATCTG AAGAAAACTTAAAAATACCC 301 GAATCCGCAT GGGCTTCAGA AGGAAGCAGA ATGTTTGTAC GTCCCGGCGA351 TACGGTCAGC ACCGACAAAC TCTTAAAAGG CATGATTGCA CTATCCGCAA 401ACGATGCCGC CCTAACCCTT GCCGGCCGGC TGGGCAACGG CTCGATTGAA 451 AATTTTGTGCAACAAATGAA CAAAGAAGCC CGACGCTTGG GCATGAAGAA 501 CACTGTATTC AAAAATCCGACAGGCTTGAG TAGAGAAGGA CAGGTTTCCA 551 CCGCCAAAGA CCTCGCCCAG CTGTCTGAAGCATTGATGCG CGACTTTCCG 601 GAATATTACC CGCTGTTTTC CATCAAATCT TTCAAATTCAAAAATATAGA 651 GCAAAACAAC CGCAATATCC TTTTATATAG GGACAACAAT GTAAACGGTC701 TGAAAGCCGG ACACACAGAA AGCGGCGGCT ACAACCTTGC CGTGTCATAC 751TCCGGCAACG GCAGGCACAT CCTTGTCATC ACATTGGGTT CGGAATCGGC 801 GGAAACACGCGCATCAGACA ACAGCAAGCT GCTGAACTGG GCATTGCAAG 851 CCTTCGATAC GCCCAAAATATATCCGAAAG GCAAAACCGT TGCCCAAATC 901 CAAATTTCCG GAGGCAGCAA AAAAACCGTCCGCGCAGGCT TCCTCAAAGA 951 AGCCTACATC ACTCTGCCAC ATAAGGAAGC GAAAATGGCAGAACAAATTC 1001 TAGAAACCAT ACAGCCGATT CCCGCCCCAG TAAAAAAAGG GCAAATTTTA1051 GGAAAAATCA AAATCAGACA AAACGGATAC ACCATTGCCG AAAAAGAAAT 1101CGTCGCACTG GAAAATGTAA AAAAAAGAAG CCGGTGGCAA AGGCTTTGGG 1151 CGTGTCTGACAGGGCAGTAAThis corresponds to the amino acid sequence <SEQ ID 1630; ORF 554.a>:

a554.pep 1 MTAHKILPVL LSIILGVSHA TAASPAPNRP TAHAAPTFQT PETLTAAHIV 51IDLQSKQILS AKNINTPVEP AALTQLMTAY LVFKNMKSGN IRSEENLKIP 101 ESAWASEGSRMFVRPGDTVS TDKLLKGMIA LSANDAALTL AGRLGNGSIE 151 NFVQQMNKEA RRLGMKNTVFKNPTGLSREG QVSTAKDLAQ LSEALMRDFP 201 EYYPLFSIKS FKFKNIEQNN RNILLYRDNNVNGLKAGHTE SGGYNLAVSY 251 SGNGRHILVI TLGSESAETR ASDNSKLLNW ALQAFDTPKIYPKGKTVAQI 301 QISGGSKKTV RAGFLKEAYI TLPHKEAKMA EQILETIQPI PAPVKKGQIL351 GKIKIRQNGY TIAEKEIVAL ENVKKRSRWQ RLWACLTGQ* m554/a554 99.2% identityin 389 aa overlap        10        20        30        40        50        60 m554.pepMTAHKILPVLLSIILGVSHATAASPAPNRPTVHAAPTFQTPETLTAAHIVIDLQSKQILS|||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||| a554MTAHKILPVLLSIILGVSHATAASPAPNRPTAHAAPTFQTPETLTAAHIVIDLQSKQILS        10        20        30        40        50        60        70        80        90       100       110       120 m554.pepAKNINTPVEPAALTQLMTAYLVFKNMKSGNIQSEENLKIPESAWASEGSRMFVRPGDTVS|||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||| a554AKNINTPVEPAALTQLMTAYLVFKNMKSGNIRSEENLKIPESAWASEGSRMFVRPGDTVS        70        80        90       100       110       120       130       140       150       160       170       180 m554.pepTDKLLKGMIALSANDAALTLAGRLGNGSIENFVQQMNKEARRLGMKNTVFKNPTGLSREG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a554TDKLLKGMIALSANDAALTLAGRLGNGSIENFVQQMNKEARRLGMKNTVFKNPTGLSREG       130       140       150       160       170       180       190       200       210       220       230       240 m554.pepQVSTAKDLALLSEALMRDFPEYYPLFSIKSFKFKNIEQNNRNILLYRDNNVNGLKAGHTE||||||||| |||||||||||||||||||||||||||||||||||||||||||||||||| a554QVSTAKDLAQLSEALMRDFPEYYPLFSIKSFKFKNIEQNNRNILLYRDNNVNGLKAGHTE       190       200       210       220       230       240       250       260       270       280       290       300 m554.pepSGGYNLAVSYSGNGRHILVITLGSESAETRASDNSKLLNWALQAFDTPKIYPKGKTVAQI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a554SGGYNLAVSYSGNGRHILVITLGSESAETRASDNSKLLNWALQAFDTPKIYPKGKTVAQI       250       260       270       280       290       300       310       320       330       340       350       360 m554.pepQISGGSKKTVRAGFLKEAYITLPHKEAKMAEQILETIQPIPAPVKKGQILGKIKIRQNGY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a554QISGGSKKTVRAGFLKEAYITLPHKEAKMAEQILETIQPIPAPVKKGQILGKIKIRQNGY       310       320       330       340       350       360       370       380       390 m554.pep TIAEKEIVALENVKKRSRWQRLWACLTGQX|||||||||||||||||||||||||||||| a554 TIAEKEIVALENVKKRSRWQRLWACLTGQX       370       380       390The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1631>:

g556.seq.. 1 atggacaata agaccaaact gcgcttgggc ggcctgattt tactgaccac 51cgccgtttta agcctcatta tcgtattgat tgtcgattcc tggccgcttg 101 ccatcctgcttgccgccgtc atcgtcgccg ccgctgcggg cggctttgtt 151 tggacatccc gccgacagcaacgccagttt atcgaacgtc tgaaaaaatt 201 cgacatcgat cccgaaaaag gcagaatcaacgaggcaaac ctgcgccgta 251 tgtaccacag cggcggacaa caccagaaag atgcgattaccctgatctgc 301 ctgtcgcaaa aatgttcggt ggacgaggcg cacgctatgt tcaaaaaacg351 cccgacacgt caggaaatca atcaaatggc ggcaaaacag tcgcgcggtc 401agaaacgtcc gcaccgttaaThis corresponds to the amino acid sequence <SEQ ID 1632; ORF 556.ng>:

g556.pep. 1 MDNKTKLRLG GLILLTTAVL SLIIVLIVDS WPLAILLAAV IVAAAAGGFV 51WTSRRQQRQF IERLKKFDID PEKGRINEAN LRRMYHSGGQ HQKDAITLIC 101 LSQKCSVDEAHAMFKKRPTR QEINQMAAKQ SRGQKRPHR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1633>:

m556.seq.. 1 ATGGACAATA AGACCAAACT GCGCTTGGGC GGCCTGATTT TACTGACCAC 51CGCCGTTTTA AGCCTCATTA TCGTATTGAT TGTCGATTCC TGGCCGCTTG 101 CCATCCTGCTTGCAGCCGTC ATTGTCGCTG CCGCTGCGGG CGGTTTTGTT 151 TGGACATCCC GCCGACAGCAACGCCAGTTT ATCGAACGCC TGAAAAAATT 201 CGACATCGAT CCCGAAAAAG GCAGAATCAACGAGGCAAAC CTGCGCCGTA 251 TGTACCACAG CGGCGGACAA CACCAGAAAG ATGCGATTACCCTGATCTGC 301 CTGTCGCAAA AATGTTCGGT GGACGAGGCG CACGCTATGT TCAAAAAACG351 CCCGACACGT CAGGAAATCA ATCAAATGGC GGCAAAACAG TCGCGCGGTC 401AGAAACGTCC GCACCGTTAAThis corresponds to the amino acid sequence <SEQ ID 1634; ORF 556>:

m556.pep.. 1 MDNKTKLRLG GLILLTTAVL SLIIVLIVDS WPLAILLAAV IVAAAAGGFV 51WTSRRQQRQF IERLKKFDID PEKGRINEAN LRRMYHSGGQ HQKDAITLIC 101 LSQKCSVDEAHAMFKKRPTR QEINQMAAKQ SRGQKRPHR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 556 shows 100.0% identity over a 139 aa overlap with a predicted ORF(ORF 556.ng) from N. gonorrhoeae:

m556/g556         10        20        30        40        50        60m556.pep MDNKTKLRLGGLILLTTAVLSLIIVLIVDSWPLAILLAAVIVAAAAGGFVWTSRRQQRQF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g556MDNKTKLRLGGLILLTTAVLSLIIVLIVDSWPLAILLAAVIVAAAAGGFVWTSRRQQRQF        10        20        30        40        50        60        70        80        90       100       110       120 m556.pepIERLKKFDIDPEKGRINEANLRRMYHSGGQHQKDAITLICLSQKCSVDEAHAMFKKRPTR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g556IERLKKFDIDPEKGRINEANLRRMYHSGGQHQKDAITLICLSQKCSVDEAHAMFKKRPTR        70        80        90       100       110       120       130       140 m556.pep QEINQMAAKQSRGQKRPHRX ||||||||||||||||||||g556 QEINQMAAKQSRGQKRPHRX        130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1635>:

a556.seq 1 ATGGACAATA AGACCAAACT GCGCTTGGGC GGCCTGATTT TACTGACCAC 51CGCCGTTTTA AGCCTCATTA TCGTATTGAT TGTCGATTCC TGGCCGCTTG 101 CCATCCTGCTTGCCGCCGTC ATCGTCGCCG CCGCTGCGGG CGGCTTTGTT 151 TGGACATCCC GCCGACAGCAACGCCAGTTT ATCGAACGTC TGAAAAAATT 201 CGACATCGAT CCCGAAAAAG GCAGAATCAACGAGGCAAAC CTGCGCCGTA 251 TGTACCACAG CGGCGGACAA CACCAAAAAG ATGCGATTACCCTGATCTGC 301 CTGTCGCAAA AATGTTCGGT GGACGAGGCG CACGCTATGT TCAAAAAACG351 CCCGACACGT CAGGAAATCA ATCAAATGGC GGCAAAACAG TCGCGCGGTC 401AGAAACGTCC GCACCGTTAAThis corresponds to the amino acid sequence <SEQ ID 1636; ORF 556.a>:

a556.pep 1 MDNKTKLRLG GLILLTTAVL SLIIVLIVDS WPLAILLAAV IVAAAAGGFV 51WTSRRQQRQF IERLKKFDID PEKGRINEAN LRRMYHSGGQ HQKDAITLIC 101 LSQKCSVDEAHAMFKKRPTR QEINQMAAKQ SRGQKRPHR* m556/a556 100.0% identity in 139 aaoverlap         10        20        30        40        50        60m556.pep MDNKTKLRLGGLILLTTAVLSLIIVLIVDSWPLAILLAAVIVAAAAGGFVWTSRRQQRQF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a556MDNKTKLRLGGLILLTTAVLSLIIVLIVDSWPLAILLAAVIVAAAAGGFVWTSRRQQRQF        10        20        30        40        50        60        70        80        90       100       110       120 m556.pepIERLKKFDIDPEKGRINEANLRRMYHSGGQHQKDAITLICLSQKCSVDEAHAMFKKRPTR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a556IERLKKFDIDPEKGRINEANLRRMYHSGGQHQKDAITLICLSQKCSVDEAHAMFKKRPTR        70        80        90       100       110       120       130       140 m556.pep QEINQMAAKQSRGQKRPHRX ||||||||||||||||||||a556 QEINQMAAKQSRGQKRPHRX        130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1637>:

g557.seq 1 atgaacaaaa tattccttac tgccgcagcc ttggtgctgg gcgcgtgcgg 51tttccacctg aaaggtgcag acggcatttc tccgccgctg acctaccgga 101 gctggcacatcgaaggcgga caggcattgc aatttccttt ggaaaccgcg 151 ctgtatcagg cttcgggcagggtggacgat gctgccggcg cgcagatgac 201 cctgcgtata gacagcgttt cccaaaacaaggaaacctat accgttaccc 251 gtgcggcagt catcaacgaa tatcttttga tattgacggttgaagcgcag 301 gtattgaaac gcggcgagcc ggtcggcaaa ccgatgaccg tgtccgtccg351 ccgcattttg gattatgccg acaacgaaat tttgggcaaa caggaagaag 401aagaaaccct gtgggcggaa atgcggcagg atgttgccga acagattgtc 451 cgccgcctgacctttctgaa ggcggaatgaThis corresponds to the amino acid sequence <SEQ ID 1638; ORF 557.ng>:

g557.pep.. 1 MNKIFLTAAA LVLGACGFHL KGADGISPPL TYRSWHIEGG QALQFPLETA 51LYQASGRVDD AAGAQMTLRI DSVSQNKETY TVTRAAVINE YLLILTVEAQ 101 VLKRGEPVGKPMTVSVRRIL DYADNEILGK QEEEETLWAE MRQDVAEQIV 151 RRLTFLKAE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1639>:

m557.seq.. 1 ATGAACAAAC TGTTTCTTAC TGCCGCAGTG CTGATGCTGG GCGCGTGCGG 51TTTCCACCTG AAAGGTGCAG ACGGCATTTC TCCGCCGCTG ACCTACCGGA 101 GCTGGCACATCGAAGGCGGA CAGGCATTGC GGTTTCCTTT GGAAACCGCG 151 CTGTATCAGG CTTCGGGCAGGGTGGACGAT GCTGCCGGCG CGCAGATGAC 201 CCTGCGTATA GACAGCGTTT CCCAAAACAAGGAAACCTAC ACCGTTACCC 251 GTGCGGCAGT CATCAACGAA TATCTTTTGA TATTGACGGTTGAAGCGCAG 301 GTATTGAAAC GCGGCGAGCC GGTCGGTAAA CCGATGACCG TGTCCGTCCG351 CCGCGTCCTT GCTTATGCCG ACAACGAGAT CTTGGGCAAA CAGGAAGAGG 401AAGCGGCATT GTGGGCGGAA ATGCGGCAGG ATGCCGCCGA ACAGATTGTC 451 CGCCGCCTGACCTTTCTGAA GGCGGAATGAThis corresponds to the amino acid sequence <SEQ ID 1640; ORF 557>:

m557.pep.. 1 MNKLFLTAAV LMLGACGFHL KGADGISPPL TYRSWHIEGG QALRFPLETA 51LYQASGRVDD AAGAQMTLRI DSVSQNKETY TVTRAAVINE YLLILTVEAQ 101 VLKRGEPVGKPMTVSVRRVL AYADNEILGK QEEEAALWAE MRQDAAEQIV 151 RRLTFLKAE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae ORF 557 shows 94.3%identity over a 159 aa overlap with a predicted ORF (ORF 557.ng) from N.gonorrhoeae:

m557/g557         10        20        30        40        50        60m557.pep MNKLFLTAAVLMLGACGFHLKGADGISPPLTYRSWHIEGGQALRFPLETALYQASGRVDD|||:|||||:|:|||||||||||||||||||||||||||||||:|||||||||||||||| g557MNKIFLTAAALVLGACGFHLKGADGISPPLTYRSWHIEGGQALQFPLETALYQASGRVDD        10        20        30        40        50        60        70        80        90       100       110       120 m557.pepAAGAQMTLRIDSVSQNKETYTVTRAAVINEYLLILTVEAQVLKRGEPVGKPMTVSVRRVL||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:| g557AAGAQMTLRIDSVSQNKETYTVTRAAVINEYLLILTVEAQVLKRGEPVGKPMTVSVRRIL        70        80       90        100       110       120       130       140       150       160 m557.pepAYADNEILGKQEEEAALWAEMRQDAAEQIVRRLTFLKAEX |||||||||||||:||||||||:||||||||||||||| g557 DYADNEILGKQEEEETLWAEMRQDVAEQIVRRLTFLKAEX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1641>:

a557.seq 1 ATGAACAAAC TGTTTCTTAC TGCCGCAGTG CTGATGCTGG GCGCGTGCGG 51TTTCCACCTG AAAGGTGCAG ACGGCATTTC TCCGCCGCTG ACCTACCGGA 101GCTGGCACAT CGAAGGCGGA CAGGCATTGC AGTTTCCTTT GGAAACCGCG 151CTGTATCAGG CTTCGGGTAG GGTGGACGAT GCTGCCGGCG CGCAGATGAC 201CCTGCGTATA GACAGCGTTT CCCAAAACAA GGAAACCTAC ACCGTTACCC 251GTGCGGCAGT CATCAACGAA TATCTTTTGA TATTGACGGT TGAAGCGCAG 301GTATTGAAAC GCGGCGAGCC GGTCGGCAAA CCGATGACCG TGTCCGTCCG 351CCGCGTCCTT GCTTATGCCG ACAACGAGAT CTTGGGCAAA CAGGAAGAGG 401AAGCGGCATT GTGGGCGGAA ATGCGGCAGG ATGCCGCCGA ACAGATTGTC 451CGCCGCCTGA CCTTTCTGAA GGCGGAATGAThis corresponds to the amino acid sequence <SEQ ID 1642; ORF 557.a>:

a557.pep 1 MNKLFLTAAV LMLGACGFHL KGADGISPPL TYRSWHIEGG QALQFPLETA 51LYQASGRVDD AAGAQMTLRI DSVSQNKETY TVTRAAVINE YLLILTVEAQ 101VLKRGEPVGK PMTVSVRRVL AYADNEILGK QEEEAALWAE MRQDAAEQIV 151 RRLTFLKAE*m557/a557 99.4% identity in 159 aa overlap        10        20        30        40        50        60 m557.pepMNKLFLTAAVLMLGACGFHLKGADGISPPLTYRSWHIEGGQALRFPLETALYQASGRVDD|||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||| a557MNKLFLTAAVLMLGACGFHLKGADGISPPLTYRSWHIEGGQALQFPLETALYQASGRVDD        10        20        30        40        50        60        70        80        90       100       110       120 m557.pepAAGAQMTLRIDSVSQNKETYTVTRAAVINEYLLILTVEAQVLKRGEPVGKPMTVSVRRVL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a557AAGAQMTLRIDSVSQNKETYTVTRAAVINEYLLILTVEAQVLKRGEPVGKPMTVSVRRVL        70        80        90       100       110       120       130       140       150       160 m557.pepAYADNEILGKQEEEAALWAEMRQDAAEQIVRRLTFLKAEX|||||||||||||||||||||||||||||||||||||||| a557AYADNEILGKQEEEAALWAEMRQDAAEQIVRRLTFLKAEX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1643>:

g558.seq.. 1 ATGGATGCTT GTTTTTTCGT CATTCCCGCA CAGGCGGGAA TTCGGAGATT 51CGGGATTGTT TTCAAACGTT CGGGTCGGAT TCTTGCCGGT GCGGGAATGA 101TGCCCTTATA TACTTTCTCC GAGCTTTATA TGCTTCAACA GGGGACGGCA 151CATCAAGCAC CGCACTGCGT GTTGCCCGAA CGAGGCTGCC CTCCGATTAG 201ATTCTATCGC TATAAACAGA CGGGTTTCAA CCGAAAAGGA ATGGGGATAA 251AGTCCATTTC CGACACCTCT CGGGCGATGC CGTCTGAAAA CCAATCTCCA 301CTTTCAGACG GCATTGTTTA GThis corresponds to the amino acid sequence <SEQ ID 1644; ORF 558.ng>:

g558.pep.. 1 MDACFFVIPA QAGIRRFGIV FKRSGRILAG AGMMPLYTFS ELYMLQQGTA 51HQAPHCVLPE RGCPPIRFYR YKQTGFNRKG MGIKSISDTS RAMPSENQSP 101 LSDGIV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1645>:

m558.seq.. 1 ATGAATGCTT GTTTTTTCGT CATTCCCACA CAGGCGGGAA TTCGGAGATT 51CGGGATTGTT TTCAAACGTT CGGGTCGGAT TCTTGCCGGT GCAGGAATGA 101TGCCCTTATA TACTTTCTCC GAGCTTTATA TGTTTCAACA GGGGACGGCA 151CATCAAGCAC CGCACTGCGT GTTGCCCGAA CGAGACTACC CTCCGATTAG 201ATTCTATCGC CATAAACAGA CGGGTTTCAA CCGAAAAGGA ATGGGGATAA 251AGTCCATTTC CGACATCTsT CGGGCGATGC CGTCTGAAAA CCAATCTCCA 301CTTTCAGACG GCATTGTTTA GThis corresponds to the amino acid sequence <SEQ ID 1646; ORF 558>:

m558.pep.. 1 MNACFFVIPT QAGIRRFGIV FKRSGRILAG AGMMPLYTFS ELYMFQQGTA 51HQAPHCVLPE RDYPPIRFYR HKQTGFNRKG MGIKSISDIX RAMPSENQSP 101 LSDGIV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 558 shows 92.5% identity over a 106 aa overlap with a predicted ORF(ORF 558.ng) from N. gonorrhoeae:

m558/g558         10        20        30        40        50        60m558.pep MNACFFVIPTQAGIRRFGIVFKRSGRILAGAGMMPLYTFSELYMFQQGTAHQAPHCVLPE|:|||||||:||||||||||||||||||||||||||||||||||:||||||||||||||| g558MDACFFVIPAQAGIRRFGIVFKRSGRILAGAGMMPLYTFSELYMLQQGTAHQAPHCVLPE        10        20        30        40        50        60        70        80        90       100 m558.pepRDYPPIRFYRHKQTGFNRKGMGIKSISDIXRAMPSENQSPLSDGIVX | |||||||:|||||||||||||||||  ||||||||||||||||| g558RGCPPIRFYRYKQTGFNRKGMGIKSISDTSRAMPSENQSPLSDGIVX        70        80        90       100The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1647>:

a558.seq 1 ATGAATGCTT GTTTTTTCGT CATTCCCACA CAGGCGGGAA TTCGGAGATT 51CGGGATTGTT TTCAAACGTT CGGGTCGGAT TCTTGCCGGT GCGGGAATGA 101TGCCCTTATA TATAGTGGAT TAAATTTAAA TCAGGACAAG GCGACGAAGC 151CGCAGACAGT ACAAATAGTA CGGCAAGGCG AGGCAACGCC GTACTGGTTT 201AAATTTAATC CACTATACTT TCTCCGAGCT TTATATGTTT CAACAGAGGA 251CGGCACATCA AGCACCGCAC TGCGTGTTGC CCGAACGAGA CTGCCCTCCG 301ATTAGATTCT ATCGCTATAA ACAGACGGGT TTCAACCGAA AAGGAATGGG 351AATGAAGTCC GTTTCCGACA CCTCTCGGGC GATGCCGTCT GAAAACCAAT 401CTCCACTTTC AGACGGCATT GTTTAGThis corresponds to the amino acid sequence <SEQ ID 1648; ORF 558.a>:

a558.pep 1 MNACFFVIPT QAGIRRFGIV FKRSGRILAG AGMMPLYIVD *I*IRTRRRS 51RRQYK*YGKA RQRRTGLNLI HYTFSELYMF QQRTAHQAPH CVLPERDCPP 101IRFYRYKQTG FNRKGMGMKS VSDTSRAMPS ENQSPLSDGI V* m558/a55870.2% identity in 141 aa overlap         10        20        30 m558.pepMNACFFVIPTQAGIRRFGIVFKRSGRILAGAGMMPLY-----------------------||||||||||||||||||||||||||||||||||||| a558MNACFFVIPTQAGIRRFGIVFKRSGRILAGAGMMPLYIVDXIXIRTRRRSRRQYKXYGKA        10        20        30        40        50        60             40        50        60        70        80 m558.pep------------TFSELYMFQQGTAHQAPHCVLPERDYPPIRFYRHKQTGFNRKGMGIKS            |||||||||| |||||||||||||| |||||||:|||||||||||:|| a558RQRRTGLNLIHYTFSELYMFQQRTAHQAPHCVLPERDCPPIRFYRYKQTGFNRKGMGMKS        70        80        90       100       110       120   90       100 m558.pep ISDIXRAMPSENQSPLSDGIVX :||  |||||||||||||||||a558 VSDTSRAMPSENQSPLSDGIVX        130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1649>:

g560.seq 1 atgctcatca tccgcaacct gatttactgg ctgatactct gttccagcct 51gattttcctc tttcccttta tgctgctcgc ctcgcctttc cgggacgggg 101cgcacaagat ggcgcgggtc tgggtcggca tcctcaactg gtcgctcaaa 151cacatcgtcg ggctcaaata ccgcatcatc ggcgcggaac acattccgga 201ccgcccctcc gtcatctgcg ccaaacacca aagcggctgg gaaacgctcg 251cgctccaaga gatttttccg ccgcaggttt acgttgccaa gcgcgagttg 301ttcaaaatcc cctttttcgg ctggggcttg aaactggtca aaaccatagg 351catagaccgc aacaaccgcc gcgaagccaa cgaacagctc ataaaacagg 401gtttggcgcg caaaaacgaa ggttattgga ttaccatttt ccccgaaggc 451acgcgccttg cgcccggaaa acgcggcaaa tacaaactcg gcggcgcgcg 501catggcgaaa atgtttgaga tggacatcgt ccccgtcgcc ctcaacagcg 551gcgaattttg gccgaaaaat tcctttctga aatatccggg ggaaatcacc 601gtcatcatct gtccgaccat cccgcacgca agcggcagcg aagccgaatt 651gatggaaaaa tgcgaacacc tcattgaaac gcaacaaccg cttatttccg 701gcgcaggccc gtttgccgcc gaaatgccgt ctgaaaccgc atgaThis corresponds to the amino acid sequence <SEQ ID 1650; ORF 560.ng>:

g560.pep.. 1 MLIIRNLIYW LILCSSLIFL FPFMLLASPF RDGAHKMARV WVGILNWSLK 51HIVGLKYRII GAEHIPDRPS VICAKHQSGW ETLALQEIFP PQVYVAKREL 101FKIPFFGWGL KLVKTIGIDR NNRREANEQL IKQGLARKNE GYWITIFPEG 151TRLAPGKRGK YKLGGARMAK MFEMDIVPVA LNSGEFWPKN SFLKYPGEIT 201VIICPTIPHA SGSEAELMEK CEHLIETQQP LISGAGPFAA EMPSET*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1651>:

m560.seq 1 ATGCTCATCA TCCGCAACCT GATTTACTGG CTGATACTCT GTTCCACCCT 51GATTTTCCTC TTTCCCTTTA TGCTGCTCGC CTCGCCTTTC CGGGACGGGG 101CGCACAAGAT GGCGCGGGTC TGGGTCGGCA TTCTCAACTG GTCGCTCAAA 151CACATCGTCG GGCTCAAATA CCGCATCATC GGCGCGGAAA ACATCCCCGA 201CCGCCCCGCC GTCATCTGCG CCAAACACCA AAGCGGCTGG GAAACGCTCG 251CCCTTCAGGA CATTTTTCCG CCGCAGGTTT ACGTTGCCAA ACGCGAGTTG 301TTCAAAATCC CCTTTTTCGG CTGGGGCTTG AAACTGGTCA AAACCATAGG 351CATAGACCGC AACAACCGCC GCGAAGCCAA CGAGCAGCTC ATAAAACAGG 401GGTTGGTGCG CAAAAACGAA GGCTATTGGA TTACCATTTT CCCCGAAGGC 451ACGCGCCTTG CGCCCGGAAA ACGCGGCAAA TACAAACTCG GCGGCGCGCG 501CATGGCGAAA ATGTTTGAGA TGGACATCGT CCCCGTCGCC CTCAACAGCG 551GCGAATTTTG GCCGAAAAAC TCCTTTCTGA AATATCCGGG GGAAATCACC 601GTCGTCATCT GTCCGACCAT CCCGCACGCA AGCGGCAGCG AAGCCGAATT 651GATGGAAAAA TGCGAACATC TCATCGAAAC GCAACAACCG CTTATTTCCG 701GCGCAGGCCC GTTTGCCGCC AAAATGCCGT CTGAAACCGC ATGAThis corresponds to the amino acid sequence <SEQ ID 1652; ORF 560>:

m560.pep 1 MLIIRNLIYW LILCSTLIFL FPFMLLASPF RDGAHKMARV WVGILNWSLK 51HIVGLKYRII GAENIPDRPA VICAKHQSGW ETLALQDIFP PQVYVAKREL 101FKIPFFGWGL KLVKTIGIDR NNRREANEQL IKQGLVRKNE GYWITIFPEG 151TRLAPGKRGK YKLGGARMAK MFEMDIVPVA LNSGEFWPKN SFLKYPGEIT 201VVICPTIPHA SGSEAELMEK CEHLIETQQP LISGAGPFAA KMPSETA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 560 shows 97.2% identity over a 246 aa overlap with a predicted ORF(ORF 560.ng) from N. gonorrhoeae:

m560/g560         10        20        30        40        50        60m560.pep MLIIRNLIYWLILCSTLIFLFPFMLLASPFRDGAHKMARVWVGILNWSLKHIVGLKYRII||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||| g560MLIIRNLIYWLILCSSLIFLFPFMLLASPFRDGAHKMARVWVGILNWSLKHIVGLKYRII        10        20        30        40        50        60        70        80        90       100       110       120 m560.pepGAENIPDRPAVICAKHQSGWETLALQDIFPPQVYVAKRELFKIPFFGWGLKLVKTIGIDR|||:|||||:||||||||||||||||:||||||||||||||||||||||||||||||||| g560GAEHIPDRPSVICAKHQSGWETLALQEIFPPQVYVAKRELFKIPFFGWGLKLVKTIGIDR        70        80        90       100       110       120       130       140       150       160       170       180 m560.pepNNRREANEQLIKQGLVRKNEGYWITIFPEGTRLAPGKRGKYKLGGARMAKMFEMDIVPVA|||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||| g560NNRREANEQLIKQGLARKNEGYWITIFPEGTRLAPGKRGKYKLGGARMAKMFEMDIVPVA       130       140       150       160       170       180       190       200       210       220       230       240 m560.pepLNSGEFWPKNSFLKYPGEITVVICPTIPHASGSEAELMEKCEHLIETQQPLISGAGPFAA|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| g560LNSGEFWPKNSFLKYPGEITVIICPTIPHASGSEAELMEKCEHLIETQQPLISGAGPFAA       190       200       210       220       230       240 m560.pepKMPSETAX :||||| g560 EMPSETXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1653>:

a560.seq 1 ATGCTCATCA TCCGCAACCT GATTTACTGG CTGATACTCT GTTCCACCCT 51GATTTTCCTC TTTCCCTTTA TGCTGCTCGC CTCGCCTTTC CGAGACGGGG 101CGCACAAGAT GGCGCGGGTC TGGGTCAAAA TCCTCAACCT CTCGCTCAAA 151CACATCGTCG GGCTCAAATA CCGCATCATC GGCGCGGAAA ACATCCCCGA 201CCGCCCCGCC GTCATCTGCG CCAAACACCA AAGCGGCTGG GAAACGCTCG 251CCCTTCAGGA CATTTTTCCG CCGCAGGTTT ACGTTGCCAA ACGCGAGTTG 301TTCAAAATCC CCTTTTTCGG CTGGGGCTTG AAACTGGTCA AAACCATAGG 351CATAGACCGC AACAACCGCC GCGAAGCCAA CGAGCAGCTC ATAAAACAGG 401GGTTGGCGCG CAAAAACGAA GGCTATTGGA TTACCATTTT CCCCGAAGGC 451ACACGCCTTG CGCCCGGAAA ACGCGGCAAA TACAAACTCG GCGGCGCGCG 501CATGGCGAAA ATGTTTGAGA TGGACATCGT CCCCGTCGCC CTCAACAGCG 551GCGAATTTTG GCCGAAAAAC TCCTTTCTGA AATATCCGGG GGAAATCACC 601GTCGTCATCT GTCCGACCAT CCCGCACGCA AGCGGCAGCG AAGCCGAATT 651GATGGGAAAA TGCGAACACC TCATCGAAAC GCAGCAGCCG CTCATTTCCG 701GCGCAGGCCC GTTTGCCGCC AAAATGCCGT CTGAAACCGC ATGAThis corresponds to the amino acid sequence <SEQ ID 1654; ORF 560.a>:

a560.pep 1 MLIIRNLIYW LILCSTLIFL FPFMLLASPF RDGAHKMARV WVKILNLSLK 51HIVGLKYRII GAENIPDRPA VICAKHQSGW ETLALQDIFP PQVYVAKREL 101FKIPFFGWGL KLVKTIGIDR NNRREANEQL IKQGLARKNE GYWITIFPEG 151TRLAPGKRGK YKLGGARMAK MFEMDIVPVA LNSGEFWPKN SFLKYPGEIT 201VVICPTIPHA SGSEAELMGK CEHLIETQQP LISGAGPFAA KMPSETA* m560/a56098.4% identity in 247 aa overlap        10        20        30        40        50        60 m560.pepMLIIRNLIYWLILCSTLIFLFPFMLLASPFRDGAHKMARVWVGILNWSLKHIVGLKYRII|||||||||||||||||||||||||||||||||||||||||| ||| ||||||||||||| a560MLIIRNLIYWLILCSTLIFLFPFMLLASPFRDGAHKMARVWVKILNLSLKHIVGLKYRII        10        20        30        40        50        60        70        80        90       100       110       120 m560.pepGAENIPDRPAVICAKHQSGWETLALQDIFPPQVYVAKRELFKIPFFGWGLKLVKTIGIDR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a560GAENIPDRPAVICAKHQSGWETLALQDIFPPQVYVAKRELFKIPFFGWGLKLVKTIGIDR        70        80        90       100       110       120       130       140       150       160       170       180 m560.pepNNRREANEQLIKQGLVRKNEGYWITIFPEGTRLAPGKRGKYKLGGARMAKMFEMDIVPVA|||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||| a560NNRREANEQLIKQGLARKNEGYWITIFPEGTRLAPGKRGKYKLGGARMAKMFEMDIVPVA       130       140       150       160       170       180       190       200       210       220       230       240 m560.pepLNSGEFWPKNSFLKYPGEITVVICPTIPHASGSEAELMEKCEHLIETQQPLISGAGPFAA|||||||||||||||||||||||||||||||||||||| ||||||||||||||||||||| a560LNSGEFWPKNSFLKYPGEITVVICPTIPHASGSEAELMGKCEHLIETQQPLISGAGPFAA       190       200       210       220       230       240 m560.pepKMPSETAX |||||||| a560 KMPSETAXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1655>:

m561.seq. 1 ATGATACTGC CAGCCCGTTT TTCAGACGGC ATCAGCCTTT CCCTGCGCCT 51GAAACTCCTG ACCGGACTGT GGGTCGGGTT GGCGGCATTG TCTGTCGTTT 101TGACACTGCT GCTCTCTTTG CGTCTGGAAA ACGCGGCCTC CGTCATCGAA 151GAGGCGGGCA ACTTGAGAAT GCAGGCATAC CGTCTGGCAT ACATGGCGGG 201TGAAGGCTCG CCCCGTGCGC AAATTGACAA TCAGGTTGCC GAATTTGAAA 251AAAGTTTAAA ACGCATTGCC CAAAGCGATG CCATCCATCC GCTGATTCCT 301TCGGACACCC CTCTTGCTTA TGATTTGATA CAATCCATGC TGATTATAGA 351TTGGCAGGCA CACATCCTCC CCCCGCTCCA GTCCTACCGG CGACCGACTC 401AGGTCGATCT CTACCGCTTT GCCGGAAACA TCGAACTGTT TTTGCAGGCA 451TTGGAAAATG CCAACGAAAA AAACACATGG TGGCTCAGGC GTTTTCAATG 501GGCAATTATG TTGATGACGC TGGTGTCGTC TGTACTGATG CTGTTTTGGC 551ACCAGATTTG GGTTATCCGG CCGCTGCAGG CGTTAAGGGA AGGTGCGGAA 601CGCATCGGAC GGAGGTGTTT CGATATTCCG GTTCCCGAAG GCGGTACGCC 651GGAATTCAAA CAGGTCGGGC GTTGTTTCAA TCAAATGGGC GGCAGGTTGA 701AAATTTTATA TGATGATTTG GAAGGACAAG TCGCCGAGCA GACACGCAGT 751CTCGAAAAAC AAAATCAAAA CCTGACCCTG CTGTACCAAA CTACACGGGA 801CCTGCACCAA TCCTACATAC CGCAACAGGC TGCAGAACAT TTTCTAAACC 851GTATCCTGCC CGCCGTAGGA GCAGATTCCG GCAGAGTTTG TTTGGACGGC 901GGATCCGATG TTTATGTTTC CATTCATCAT GCGGATTGCG GCACAGCAGC 951TTCGGATTTG GGGAAGTACC ATGAGGAAAT CTTCCCCATT GAGTACCAGA 1001ACGAAACATT GGGCAGGCTG TTGCTCAGCT TTCCAAACGG CATTTCTCTT 1051GATGAAGACG ACCGCATCCT GCTTCAAACA CTAGGCAGGC AATTGGGCGT 1101ATCGCTTGCC GGCGCAAAAC AGGAGGAAGA AAAACGCCTG CTTGCAGTAT 1151TGCAGGAACG CAACCTGATT GCGCAAGGAT TACATGACAG CATCGCACAA 1201GCATTAACGT TCCTAAACCT ACAGGTACAG ATGCTGGAAA CCGCCTTTGC 1251CGAAAACAAA CGGGAGGAAG CCGCAGAAAA CATCAGCTTT ATCAAAACAG 1301GCGTGCAGGA ATGTTATGAA GATGTCCGCG AACTGCTGCT CAACTTCCGT 1351ACCAAAATCA GCAATAAAGA ATTTCCCGAA GCCGTTGCCG ACCTATTCGC 1401CCGCTTTACG CAACAAACCG GGATAACGGT CGAAACCGCC TGGGAAAACG 1451GTTCGTTCCT GCCGCCTCAG GAAGCGCAGC TCCAAATGAT TTTTATCCTG 1501CAGGAAAGCC TGTCCAACAT CCGCAAACAC GCCCGCGCCA CCCATGTAAA 1551ATTCACCCTT TCCGAACACG GCGGACGCTT TACCATGACC ATCCAAGACA 1601ACGGACAAGG TTTCGACACG GAGAAAATAG GAGAACCCAC GGGCAGCCAT 1651GTCGGACTGC ACATCATGCA GGAGCGTGCC AAACGCATCC ATGCCGTTTT 1701AGAAATCCGT TCCCAAGCTC AACAGGGAAC CACCGTCTCA TTGACGGTTG 1751CATCTGAAGA AAGCTTGAAA TGAThis corresponds to the amino acid sequence <SEQ ID 1656; ORF 561>:

m561.pep 1 MILPARFSDG ISLSLRLKLL TGLWVGLAAL  SVVLTLLLSL RLENAASVIE 51EAGNLRMQAY RLAYMAGEGS PRAQIDNQVA EFEKSLKRIA QSDAIHPLIP 101SDTPLAYDLI QSMLIIDWQA HILPPLQSYR RPTQVDLYRF AGNIELFLQA 151LENANEKNTW WLRRFQWAIM LMTLVSSVLM LFWHQIWVIR PLQALREGAE 201RIGRRCFDIP VPEGGTPEFK QVGRCFNQMG GRLKILYDDL EGQVAEQTRS 251LEKQNQNLTL LYQTTRDLHQ SYIPQQAAEH FLNRILPAVG ADSGRVCLDG 301GSDVYVSIHH ADCGTAASDL GKYHEEIFPI EYQNETLGRL LLSFPNGISL 351DEDDRILLQT LGRQLGVSLA GAKQEEEKRL LAVLQERNLI AQGLHDSIAQ 401ALTFLNLQVQ MLETAFAENK REEAAENISF IKTGVQECYE DVRELLLNFR 451TKISNKEFPE AVADLFARFT QQTGITVETA WENGSFLPPQ EAQLQMIFIL 501QESLSNIRKH ARATHVKFTL SEHGGRFTMT IQDNGQGFDT EKIGEPTGSH 551VGLHIMQERA KRIHAVLEIR SQAQQGTTVS LTVASEESLK *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m561/g561 89.7% identity in 223 aa overlap        10        20        30        40        50        60 m561.pepMILPARFSDGISLSLRLKLLTGLWVGLAALSVVLTLLLSLRLENAASVIEEAGNLRMQAY ||||:|||||||||||||||||||||||||||||||||:|||||||||||||||:|||| g561MILPTRFSDGIPLSLRLKLLTGLWVGLAALSVVLILLLSFRLENAASVIEEAGNLKMQAY        10        20        30        40        50        60        70        80        90       100       110       120 m561.pepRLAYMAGEGSPRAQIDNQVAEFEKSLKRIAQSDAIHPLIPSDTPLAYDLIQSMLIIDWQA||||||||||||||||||:||||||||||:||||||||||||:||||||||||||||||| g561RLAYMAGEGSPRAQIDNQIAEFEKSLKRISQSDAIHPLIPSDNPLAYDLIQSMLIIDWQA        70        80        90       100       110       120       130       140       150       160       170       180 m561.pepHILPPLQSYRRPTQVDLYRFAGNIELFLQALENANEKNTWWLRRFQWAIMLMTLVSSVLM:||||||:||||||::||||||||||||||||||:||||||||||||:|||||||||||| g561NILPPLQAYRRPTQIELYRFAGNIELFLQALENAGEKNTWWLRRFQWVIMLMTLVSSVLM       130       140       150       160       170       180       190       200       210       220       230       240 m561.pepLFWHQIWVIRPLQALREGAERIGRRCFDIPVPEGGIPEFKQVGRCFNQMGGRLKILYDDL|||||||||||||||||||||||:| |||||||   |: :: | g561LFWHQIWVIRPLQALREGAERIGQRHFDIPVPEDVRPNSNRSGGVSTKWRSGX       190       200       210       220       230       250       260       270       280       290       300 m561.pepEGQVAEQTRSLEKQNQNLTLLYQTTRDLHQSYIPQQAAEHFLNRILPAVGADSGRVCLDGThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1657>:

a561.seq 1 ATGATACTGC CAGCCCGTTT TTCAGACGGC ATCAGCCTTT CCCTGCGCCT 51GAAACTCCTG ACCGGACTGT GGGTCGGGTT GGCGGCATTG TCTGTCGTTT 101TGACACTGCT GCTCTCTTTG CGTCTGGAAA ACGCGGCCTC CGTCATCGAA 151GAGGCGGGCA ACTTGAGAAT GCAGGCATAC CGTCTGGCAT ACATGGCGGG 201TGAAGGCTCG CCCCGTGCGC AAATTGACAA TCAGGTTGCC GAATTTGAAA 251AAAGTTTAAA ACGCATTGCC CAAAGCGATG CCATCCATCC GCTGATTCCT 301TCGGACACCC CTCTTGCTTA TGATTTGATA CAATCCATGC TGATTATAGA 351TTGGCAGGCA CACATCCTCC CCCCGCTCCA GTCCTACCGG CGACCGACTC 401AGGTCGATCT CTACCGCTTT GCCGGAAACA TCGAACTGTT TTTGCAGGCA 451TTGGAAAATG CCAACGAAAA AAACACATGG TGGCTCAGGC GTTTTCAATG 501GGCAATTATG TTGATGACGC TGGTGTCGTC TGTACTGATG CTGTTTTGGC 551ACCAGATTTG GGTTATCCGG CCGCTGCAGG CGTTAAGGGA AGGTGCGGAA 601CGCATCGGAC GGAGGTGTTT CGATATTCCG GTTCCCGAAG GCGGTACGCC 651GGAATTCAAA CAGGTCGGGC GTTGTTTCAA TCAAATGGGC GGCAGGTTGA 701AAATTTTATA TGATGATTTG GAAGGACAAG TCGCCGAGCA GACACGCAGT 751CTCGAAAAAC AAAATCAAAA CCTGACCCTG CTGTACCAAA CTACACGGGA 801TCTGCACCAA TCCTACATAC CGCAACAGGC TGCAGAACAT TTTCTAAACC 851GTATCCTGCC CGCCGTAGGA GCAGATTCCG GCAGAGTTTG TTTGGACGGC 901GGATCCGATG TTTATGTTTC CATTCATCAT GCGGATTGCG GCACAGCAGC 951TTCGGATTTG GGGAAGTACC ATGAGGAAAT CTTCCCCATT GAGTACCAGA 1001ACGAAACATT GGGCAGGCTG TTGCTCAGCT TTCCAAACGG CATTTCTCTT 1051GATGAAGACG ACCGCATCCT GCTTCAAACA CTAGGCAGGC AATTGGGCGT 1101ATCGCTTGCC GGCGCAAAAC AGGAGGAAGA AAAACGCCTG CTTGCAGTAT 1151TGCAGGAACG CAACCTGATT GCGCAAGGAT TACATGACAG CATCGCACAA 1201GCATTAACGT TCCTAAACCT ACAGGTACAG ATGCTGGAAA CCGCCTTTGC 1251CGAAAACAAA CGGGAGGAAG CCGCAGAAAA CATCGGCTTC ATCAAAACAG 1301GCGTGCAGGA ATGTTATGAA GATGTCCGCG AACTGCTGCT CAACTTCCGT 1351ACCAAAATCA GTAATAAAGA ATTTCCCGAA GCCGTTGCCG ACCTATTCTC 1401GCGCTTTACG CAACAGACCG GCACGACTGT CGAAACCGCT TGGGAAAACG 1451GCACGCACCT GCCTACACAG GACGAGCAGC TCCAAATGAT TTTCATCCTG 1501CAAGAAAGCT TGTCCAACAT CCGAAAACAT GCCCACGCCA CCCATATCAA 1551ATTCAGACTG CTCAAACAGG ATGGAAGTTT TACAATGACC ATTCAAGACA 1601ACGGACAGGG TTTTGACACG GAAAACATTG GAGAACCATC GGGCAGCCAT 1651GTCGGACTGC ATATCATGCA GGAGCGTGCC AAACGCATCC ATGCCGTTTT 1701AGAAATCCGT TCCCAAGCTC AACAGGGAAC CACCGTCTCA TTGACGGTTG 1751CATCTGAAGA AAGCTTGAAA TGAThis corresponds to the amino acid sequence <SEQ ID 1658; ORF 561.a>:

a561.pep 1 MILPARFSDG ISLSLRLKLL TGLWVGLAAL SVVLTLLLSL RLENAASVIE 51EAGNLRMQAY RLAYMAGEGS PRAQIDNQVA EFEKSLKRIA QSDAIHPLIP 101SDTPLAYDLI QSMLIIDWQA HILPPLQSYR RPTQVDLYRF AGNIELFLQA 151LENANEKNTW WLRRFQWAIM LMTLVSSVLM LFWHQIWVIR PLQALREGAE 201RIGRRCFDIP VPEGGTPEFK QVGRCFNQMG GRLKILYDDL EGQVAEQTRS 251LEKQNQNLTL LYQTTRDLHQ SYIPQQAAEH FLNRILPAVG ADSGRVCLDG 301GSDVYVSIHH ADCGTAASDL GKYHEEIFPI EYQNETLGRL LLSFPNGISL 351DEDDRILLQT LGRQLGVSLA GAKQEEEKRL LAVLQERNLI AQGLHDSIAQ 401ALTFLNLQVQ MLETAFAENK REEAAENIGF IKTGVQECYE DVRELLLNFR 451TKISNKEFPE AVADLFSRFT QQTGTTVETA WENGTHLPTQ DEQLQMIFIL 501QESLSNIRKH AHATHIKFRL LKQDGSFTMT IQDNGQGFDT ENIGEPSGSH 551VGLHIMQERA KRIHAVLEIR SQAQQGTTVS LTVASEESLK * m561/a56196.9% identity in 590 aa overlap        10        20        30        40        50        60 m561.pepMILPARFSDGISLSLRLKLLTGLWVGLAALSVVLILLLSLRLENAASVIEEAGNLRMQAY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a561MILPARFSDGISLSLRLKLLTGLWVGLAALSVVLILLLSLRLENAASVIEEAGNLRMQAY        10        20        30        40        50        60        70        80        90       100       110       120 m561.pepRLAYMAGEGSPRAQIDNQVAEFEKSLKRIAQSDAIHPLIPSDTPLAYDLIQSMLIIDWQA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a561RLAYMAGEGSPRAQIDNQVAEFEKSLKRIAQSDAIHPLIPSDTPLAYDLIQSMLIIDWQA        70        80        90       100       110       120       130       140       150       160       170       180 m561.pepHILPPLQSYRRPTQVDLYRFAGNIELFLQALENANEKNTWWLRRFQWAIMLMTLVSSVLM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a561HILPPLQSYRRPTQVDLYRFAGNIELFLQALENANEKNTWWLRRFQWAIMLMTLVSSVLM       130       140       150       160       170       180       190       200       210       220       230       240 m561.pepLFWHQIWVIRPLQALREGAERIGRRCFDIPVPEGGTPEFKQVGRCFNQMGGRLKILYDDL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a561LFWHQIWVIRPLQALREGAERIGRRCFDIPVPEGGTPEFKQVGRCFNQMGGRLKILYDDL       190       200       210       220       230       240       250       260       270       280       290       300 m561.pepEGQVAEQTRSLEKQNQNLTLLYQTTRDLHQSYIPQQAAEHFLNRILPAVGADSGRVCLDG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a561EGQVAEQTRSLEKQNQNLTLLYQTTRDLHQSYIPQQAAEHFLNRILPAVGADSGRVCLDG       250       260       270       280       290       300       310       320       330       340       350       360 m561.pepGSDVYVSIHHADCGTAASDLGKYHEEIFPIEYQNETLGRLLLSFPNGISLDEDDRILLQT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a561GSDVYVSIHHADCGTAASDLGKYHEEIFPIEYQNETLGRLLLSFPNGISLDEDDRILLQT       310       320       330       340       350       360       370       380       390       400       410       420 m561.pepLGRQLGVSLAGAKQEEEKRLLAVLQERNLIAQGLHDSIAQALTFLNLQVQMLETAFAENK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a561LGRQLGVSLAGAKQEEEKRLLAVLQERNLIAQGLHDSIAQALTFLNLQVQMLETAFAENK       370       380       390       400       410       420       430       440       450       460       470       480 m561.pepREEAAENISFIKTGVQECYEDVRELLLNFRTKISNKEFPEAVADLFARFTQQTGITVETA||||||||:|||||||||||||||||||||||||||||||||||||:||||||| ||||| a561REEAAENIGFIKTGVQECYEDVRELLLNFRTKISNKEFPEAVADLFSRFTQQTGTTVETA       430       440       450       460       470       480       490       500       510       520       530       540 m561.pepWENGSFLPPQEAQLQMIFILQESLSNIRKHARATHVKFTLSEHGGRFTMTIQDNGQGFDT ||||: |||: |||||||||||||||||||:|||:|| | :: | |||||||||||||| a561WENGTHLPTQDEQLQMIFILQESLSNIRKHAHATHIKFRLLKQDGSFTMTIQDNGQGFDT       490       500       510       520       530       540       550       560       570       580       590 m561.pepEKIGEPTGSHVGLHIMQERAKRIHAVLEIRSQAQQGTTVSLTVASEESLKX|:||||:|||||||||||||||||||||||||||||||||||||||||||| a561ENIGEPSGSHVGLHIMQERAKRIHAVLEIRSQAQQGTTVSLTVASEESLKX       550       560       570       580       590The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1659>:

g562.seq.. 1 atggcaagcc cgtcgagtct gcctttcaat tcgggcaaga ccaaaccgac 51ggcttttgcc gcgccggttt tggtcggaat catgttttcc acgccgctgc 101gggcgcggcg caggtctttg tggcgcacgt cggtaacggt ttggtcgttg 151gtcagtgcgt ggatggtggt cattgcgcct ttgacgatgc cgacgctttc 201gctcaacact ttggcaaccg gcgagaggca gttggtggtg caggaagcgt 251tggaaacgac ggtcatgtcg gcggtcagga cgctgtcgtt cacgccgtac 301acgacggttg catcgacatc gtcgccgccc ggtgcggaaa tgaggacttt 351tttcgcgccg ctttcgaggt ggattttggc tttttctttg ctggtgaacg 401cgccggtgca ttccatgacc aaatcgacac cgagttcttt ccacggcagt 451tcggcagggt tgcgggtcga gaagaagggg attttgtcgc cgttgacgat 501gaggttgccg ccgtcgtggg atacgtcggc ttcaaagcgt ccgtgtacgg 551tgtcgaattt ggtcagatgg gcgttggttt caaggctgcc gctggcgttg 601acggcgacga tttggagttg gtcttgaThis corresponds to the amino acid sequence <SEQ ID 1660; ORF 562.ng>:

g562.pep 1 MASPSSLPFN SGKTKPTAFA APVLVGIMFS TPLRARRRSL WRTSVTVWSL 51VSAWMVVIAP LTMPTLSLNT LATGERQLVV QEALETTVMS AVRTLSFTPY 101TTVASTSSPP GAEMRTFFAP LSRWILAFSL LVNAPVHSMT KSTPSSFHGS 151SAGLRVEKKG ILSPLTMRLP PSWDTSASKR PCTVSNLVRW ALVSRLPLAL 201 TATIWSWS*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1661>:

m562.seq 1 ATGGCAAGCC CGTCGAGCCT GCCTTTCAAT TCGGGCAGTA CCAAACCGAC 51GGCTTTTGCC GCGCCGGTTT TGGTCGGAAT CATGTTTTCC ACGCCGCTGC 101GGGCGCGGCG CAGGTCTTTG TGGCGCACGT CGGTAACGGT TTGGTCGTTG 151GTCAGCGCGT GGATGGTGGT CATCGCGCCT TTGACGATGC CGACGCTTTC 201GCTCAACACT TTGGCAACCG GCGAGAGGCA GTTGGTGGTG CAGGAAGCGT 251TGGAAACGAC GGTCATGTCG GCGGTCAGGA CGCTGTCGTT CACGCCGTAC 301ACGACGGTTG CATCGACATC GTCGCCGCCC GGTGCGGAAA TGAGGACTTT 351TTTCGCGCCG CTTTCGAGGT GGATTTTGGC TTTTTCTTTG CTGGTGAACG 401CGCCGGTGCA TTCCATGACC AAATCGACAC CGAGTTCTTT CCACGGCAGT 451TCGGCAGGGT TGCGGGTCGA GAAGAAGGGG ATTTTGTCGC CGTTGACGAT 501GAGGTTGCCG CCGTCGTGGG ATACGTCGGC TTCAAAGCGT CCGTGCACGG 551TGTCGAATTT GGTCAGATGG GCGTTGGTTT CAAGGCTGCC GCTGGCGTTG 601ACGGCGACGA GTTGGAGTTG GTCTTGAThis corresponds to the amino acid sequence <SEQ ID 1662; ORF 562>:

m562.pep 1 MASPSSLPFN SGSTKPTAFA APVLVGIMFS TPLRARRRSL WRTSVTVWSL 51VSAWMVVIAP LTMPTLSLNT LATGERQLVV QEALETTVMS AVRTLSFTPY 101TTVASTSSPP GAEMRTFFAP LSRWILAFSL LVNAPVHSMT KSTPSSFHGS 151SAGLRVEKKG ILSPLTMRLP PSWDTSASKR PCTVSNLVRW ALVSRLPLAL 201 TATSWSWS*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m562/g562 99.0% identity in 208 aa overlap        10        20        30        40        50        60 m562.pepMASPSSLPFNSGSTKPTAFAAPVLVGIMFSTPLRARRRSLWRTSVTVWSLVSAWMVVIAP||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| g562MASPSSLPFNSGKTKPTAFAAPVLVGIMFSTPLRARRRSLWRTSVTVWSLVSAWMVVIAP        10        20        30        40        50        60        70        80        90       100       110       120 m562.pepLTMPTLSLNTLATGERQLVVQEALETTVMSAVRTLSFTPYTTVASTSSPPGAEMRTFFAP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g562LTMPTLSLNTLATGERQLVVQEALETTVMSAVRTLSFTPYTTVASTSSPPGAEMRTFFAP        70        80        90       100       110       120       130       140       150       160       170       180 m562.pepLSRWILAFSLLVNAPVHSMTKSTPSSFHGSSAGLRVEKKGILSPLTMRLPPSWDTSASKR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g562LSRWILAFSLLVNAPVHSMTKSTPSSFHGSSAGLRVEKKGILSPLTMRLPPSWDTSASKR       130       140       150       160       170       180       190       200      209 m562.pep PCTVSNLVRWALVSRLPLALTATSWSWSX||||||||||||||||||||||| ||||| g562 PCTVSNLVRWALVSRLPLALTATIWSWSXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1663>:

a562.seq 1 ATGGCAAGCC CGTCGAGTTT GTCTTTCAAT TCGGGCAGTA CCAAACCGAC 51GGCTTTTGCC GCGCCAGTTT TGGTCGGAAT CATGTTTTCC ACGCCGCTGC 101GGGCGCGGCG CAGGTCTTTG TGGCGCACGT CGGTAACGGT TTGGTCGTTG 151GTCAGCGCGT GGATGGTGGT CATCGCGCCT TTGACGATGC CGACGCTTTC 201GCTCAACACT TTGGCAACCG GCGAGAGGCA GTTGGTGGTG CAGGAAGCGT 251TGGAAACGAC GGTCATGTCG GCGGTCAGGA TGCTGTCGTT CACGCCGTAC 301ACGACGGTTG CATCGACATC GTCGCCGCCC GGTGCGGAAA TGAGGACTTT 351TTTCGCGCCG CTTTCCAGAT GAACTTTGGC TTTTTCTTTG CTGGTGAACG 401CGCCGGTGCA TTCCATGACC AAATCGACAC CGAGTTCTTT CCACGGCAGT 451TCGGCAGGGT TGCGGGTCNA GAAGAANGGG ATTTTGTCGC CGTTGACGAT 501GAGGTTGCCG CCGTCGTGGG ATACGTCGGC TTCAAAGCGT CCGTGCACGG 551TGTCGAATTT GGTGAGGTGG GCGTTGGTTT CAAGGCTGCC GCTGGCGTTG 601ACGGCGACGA TTTGGAGTTG GTCTTGAThis corresponds to the amino acid sequence <SEQ ID 1664; ORF 562.a>:

a562.pep 1 MASPSSLSFN SGSTKPTAFA APVLVGIMFS TPLRARRRSL WRTSVTVWSL 51VSAWMVVIAP LTMPTLSLNT LATGERQLVV QEALETTVMS AVRMLSFTPY 101TTVASTSSPP GAEMRTFFAP LSR*TLAFSL LVNAPVHSMT KSTPSSFHGS 151SAGLRVXKXG ILSPLTMRLP PSWDTSASKR PCTVSNLVRW ALVSRLPLAL 201 TATIWSWS*m562/a562 96.6% identity in 208 aa overlap        10        20        30        40        50        60 m562.pepMASPSSLPFNSGSTKPTAFAAPVLVGIMFSTPLRARRRSLWRTSVTVWSLVSAWMVVIAP ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a562MASPSSLSFNSGSTKPTAFAAPVLVGIMFSTPLRARRRSLWRTSVTVWSLVSAWMVVIAP        10        20        30        40        50        60        70        80        90       100       110       120 m562.pepLTMPTLSLNTLATGERQLVVQEALETTVMSAVRTLSFTPYTTVASTSSPPGAEMRTFFAP||||||||||||||||||||||||||||||||| |||||||||||||||||||||||||| a562LTMPTLSLNTLATGERQLVVQEALETTVMSAVRMLSFTPYTTVASTSSPPGAEMRTFFAP        70        80        90       100       110       120       130       140       150       160       170       180 m562.pepLSRWILAFSLLVNAPVHSMTKSTPSSFHGSSAGLRVEKKGILSPLTMRLPPSWDTSASKR ||| ||||||||||||||||||||||||||||||| | ||||||||||||||||||||| a562LSRXTLAFSLLVNAPVHSMTKSTPSSFHGSSAGLRVXKXGILSPLTMRLPPSWDTSASKR       130       140       150       160       170       180       190       200      209 m562.pep PCTVSNLVRWALVSRLPLALTATSWSWSX||||||||||||||||||||||| ||||| a562 PCTVSNLVRWALVSRLPLALTATIWSWSX       190       200The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 1665>:

g563.seq 1 ATGAACAAAA CCCTCTATCG TGTGATTTTC AACCGCAAAC GCGGTGCTGT 51GGTAGCTGTT GCCGAAACCA CCAAGCGCGA AGGTAAAAGC TGTGCCGATA 101GTGGTTCGGG CAGCGTTTAT GTGAAATCCG TTTCTTTCAT TCCTACTCAT 151TCCAAAGCCT TTTGTTTTTC TGCATTAGGC TTTTCTTTAT GTTTGGCTTT 201GGGTACGGTC AATATTGCTT TTGCTGACGG CATTATTACT GATAAAGCTG 251CTCCTAAAAC CCAACAAGCC ACGATTCTGC AAACAGGTAA CGGCATACCG 301CAAGTCAATA TTCAAACCcc tACTTCGGCa ggGGTTTCTG TTAATCAATA 351TGCCCAGTTT GATGTGGGTA ATcgcGGGGC GATTTTAAAC AACAGTCGCA 401GCAACACCCA AACACAGCTA GGCGGTTGGA TTCAAGGCAA TCCTTGGTTG 451ACAAGGGGCG AAGCACGTGT GGTTGTAAAC CAAATCAACA GCAGCCATCC 501TTCACAACTG AATGGCTATA TTGAAGTGGG TGGACGACGT GCAGAAGTCG 551TTATTGCCAA TCCGGCAGGG ATTGCAGTCA ATGGTGGTGG TTTTATCAAT 601GCTTCCCGTG CCACTTTGAC GACAGGCCAA CCGCAATATC AAGCAGGAGA 651CTTTAGCGGC TTTAAGATAA GGCAAGGCAA TGCTGTAATC GCCGGACACG 701GTTTGGATGC CCGTGATACC GATTTCACAC GTATTCTTTT GTATGCCAAC 751AAAATCACCT TGATCAGTAC GGCCGAACAA GCAGGCATTC GTAATCAAGG 801GCAGTTGTTT GCTTCTTCCG GTAATGTGGC GATTGATGCA AATGGCCGTT 851TGGTCAATAG TGGCACGATG GCTGCCGCCA ATGTGCAAGA TATGAATAAT 901ACAGCGGAAC ACAAAGTCAA TATCCGCAGT CAAGCCTTTG AAAACAGCGG 951TACGGCGGTA TCGCAACAAG GCACTCAAAT TCACAGTCAA TCGATTCAAA 1001ACACTGGCAA ATTATTGTCG GCAGGAACAG AGGATTTAGC CGTTTCAGGC 1051AGCCTGAACA ATCAAAATGG CGAAATAGCG ACCAATCAAC AACTGATTAT 1101TCACGATGGT CAGCAATCTA CCGTTGTCAT TGATAATACG AATGGCACGA 1151TACAATCAGG CCGTGATGTT GCCATTCAGG CAAAATCGTT ATCCAACAAC 1201GGCACACTTG CCGCTGATAA TAAACTGGAT ATTGCGTTAC AAGATGATTT 1251TTATGTAGAA CGCAAGATCG TGGCGGGCAA TGAATTGTCG CTCAGTACAC 1301GAGGCAGCCT GAAAAATTCA CATACCTTGC AAGCAGGAAA ACGCATTCGG 1351ATTAAAGCAA ATAACCTTGA TAATGCAGTA CAAGGCAACA TTCAATCCGG 1401CGGTACGACA GACATTGGCA CGCAGCACAA TTTAACCAAT AGAGGCTTGA 1451TTGACGGACA ACAAACCAAA ATCCAAGCCG GGCAAATGAA TAATATCGGT 1501ACAGGTCGGA TTTATGGCGA CAATATCGCT ATTGCGGCTA CCCGCTTAGA 1551CAATCAAGAT GAAAACGGTA CAGGTGCCGC CATTGCGGCA CGCGAAAACC 1601TGAATTTAGG CATTGAACAA TTAAATAACC GTGAAAACAG TCTGATTTAC 1651AGCGGTAACG ATATGGCGGT TGGCGGCGCA TTAGATACCA ATGACCAAGC 1701CACAGGCAAA GCCCAAAGGA TACACAATGC CGGCGCAATC ATTGAAGCTG 1751CAGGCAAAAT GCGTTTAGGT GTAGAAAAGC TGCACAATAC CAATGAGCAT 1801TTGAAAACGC AGTTGGTAGA AACAGGGCGC GAGCGTATTG TTGATTACGA 1851AGCATTTGGA CGACACGAAT TATTGCGAGA AGGCACGCAA CATGAATTAG 1901GCTGGTTTGT CTACAACAAT GAATCAGACC ACTTACGCAC CCCTGATGGA 1951GTGGCGCATG AAAATTGGCA TAAATACGAT TATGAAAAAG TAACGCAAGA 2001AACTCAAGTA ACCGGAACTG CGCCTGCTAA AATCATTGCA GGTAGCGATT 2051TGATTATTGA TAGCAAAGCA GTCTTCAACA GCGACAGCCG AATCATTGCC 2101GGCGGCCAAT TGCTTGTGCA AACAGAAAAA GACGGTTTGC ATAACGAGCA 2151AACCTTTGGC GAGAAGAAAG TCTTCAGCGA AAATGGTAAG TTGCACAACT 2201ACTGGCGTGC GCGTCGTAAA GGACATGATG AAACAGGGCA TCGTGAACAA 2251AATTATACTT TGCCGGAGGA AATCACACGC GACATTTCAC TGGGTTCATT 2301TGCCTATGAA TCGCATAGCA AAGCATTAAG CCGTCATGCG CCCAGCCAAG 2351GCACTGAGTT GCCACAAAGT AACCGGGATA ATATCCGTAC TGCGAAAAGC 2401AACGGTATTT CGCTACCCTA TACGCCCAAT TCTTTTACCC CATTACCCGG 2451CAGCAGCTTA TACATTATCA ATCCTGCCAA TAAAGGCTAT CTTGTTGAAA 2501CCGATCCACG CTTTGCCAAC TACCGTCAAT GGTTGGGTAG TGACTATATG 2551CTGGGCAGCC TCAAACTAGA CCCAAACAAT TTACATAAAC GTTTGGGTGA 2601TGGTTATTAC GAGCAACGTT TAATCAATGA ACAAATCGCA GAGCTGACAG 2651GGCATCGTCG TTTAGACGGT TATCAAAACG ACGAAGAACA ATTTAAAGCC 2701TTAATGGATA ATGGCGCGAC TGCGGCACGT TCGATGAATC TCAGCGTTGG 2751CATTGCATTA AGTGCCGAGC AAGCAGCGCA ACTGACCAGC GATATTGTTT 2801GGTTGGTACA AAAAGAAGTT AAACTTCCTG ATGGCGGCAC ACAAACCGTA 2851TTGATGCCAC AGGTTTATGT ACGCGTTAAA AATGGCGGCA TAGACGGTAA 2901AGGTGCATTG TTGTCAGGCA GCAATACACA AATCAATGTT TCAGGCAGCC 2951TGAAAAACTC AGGCACGATT GCAGGGCGCA ATGCGCTTAT TATCAATACC 3001GATACGCTAG ACAATATCGG TGGGCGTATT CATGCGCAAA AATCAGCGGT 3051TACGGCCACA CAAGACATCA ATAATATTGG CGGCATTCTT TCTGCCGAAC 3101AGACATTATT GCTCAATGCG GGTAACAACA TCAACAACCA AAGCACGGCC 3151AAGAGCAGTC AAAATGCACA AGGTAGCAGC ACCTACCTAG ACCGAATGGC 3201AGGTATTTAT ATCACAGGCA AAGAAAAAGG TGTTTTAGCA GCGCAGGCAG 3251GCAAAGACAT CAACATCATT GCCGGTCAAA TCAGCAATCA ATCAGATCAA 3301GGGCAAACCC GGCTGCAGGC AGGACGCGAC ATTAACCTGG ATACGGTACA 3351AACCGGCAAA TATCAAGAAA TCCATTTTGA TGCCGATAAC CATACCATCC 3401GAGGTTCAAC GAACGAAGTC GGCAGCAGCA TTCAAACAAA AGGCGATGTT 3451ACCCtatTGT CAGGGAATAA TCTCAATGCC AAAGCTGCCG AAGTCGGCAG 3501CGCAAAAGGC ACACTTGCCG TGTATGCTAA AAATGACATT ACTATCAGCT 3551CAGGCATCCA TGCCGGCCAA GTTGATGATG CGTCCAAACA TACAGGCAGA 3601AGCGGCGGCG GTAATAAATT AGTCATTACC GATAAAGCCC AAAGTCATCA 3651CGAAACTGCT CAAAGCAGCA CCTTTGAAGG CAAGCAAGTT GTATTGCAGG 3701CAGGAAACGA TGCCAACATC CTTGGCAGTA ATGTTATTTC CGATAATGGC 3751ACCCGGATTC AAGCAGGCAA TCATGTTCGC ATTGGTACAA CCCAAACTCA 3801AAGCCAAAGC GAAACCTATC ATCAAACCCA AAAATCAGGA TTGATGAGTG 3851CAGGTATCGG CTTCACTATT GGCAGCAAGA CAAACACACA AGAAAACCAA 3901TCCCAAAGCA ACGAACATAC AGGCAGTACC GTAGGCAGCC TGAAAGGCGA 3951TACCACCATT GTTGCAAGCA AACACTACGA ACAAACCGGC AGCAACGTTT 4001CCAGCCCTGA GGGCAACAAC CTTATCAGCA CGCAAAGTAT GGATATTGGC 4051GCAGCACAAA ACCAATTAAA CAGCAAAACC ACCCAAACCT ACGAACAAAA 4101AGGCTTAACG GTGGGCATTC AGTTCGCCCG TTACCGATTT GGCACAACAA 4151GCGATTGCCG TAGCACACAA AGCAGCAAAC AAGTCGGACA AAGCAAAAAC 4201GACCGCGTTA ATGCCATGGC GGCTGCCAAT GCAGGTTGGC AGGCCTATCA 4251AACAGGCAAA GGCGCACAAA ACTTAGCCAA TGGTACAACC AATGCCAAAC 4301AAGTCAGCAT CTCCATAACC TACGGCGAAC AGCAAAACCG ACAAACCACC 4351CAAGTTCAAG CCAATCAAGC CCAAGCGAGT CAAATTCAAG CAGGCGGCAA 4401AACTACCCTT TATTGCCGAA GGTGCGGCGA ACAATCCAAT ATCAACATCA 4451CAGGCTCAGG TGTTTCAGGC AGAGCAGGAA CCGGCCTGAT TGCCGATAAG 4501CAAATCCATC TGCAATCAGC CGAGCAAAGC AATACCGAAC GCAGCCAAAA 4551CAAATCAGCA GGCTGGAACG CAGGTGCTGC CGTATCATTC GGACAAGGAG 4601GCTGGTCATT AGGCGTTGCC GCAGGCGGCA ATGTCGGCAA AGGCTACGGC 4651TATGGCGATA GCGTAACCCA CCGCCATAGC CATATTGGCG ACAAAGGCAG 4701CCAAACCCTT ATCCAAAGTG GTGGCGATAC CATCATCAAA GGCGCGCAAG 4751TACGCGGCAA AGGCGTACAA GTCAATGCCA AAAACCTAAG CATTCAAAGT 4801GTACAAGATA GAGAAACTTA TCAAAGCAAA CAACAAAACG CCGGTGCACA 4851AGTTACCGTA GGTTATGGCT TCAGTGCCAG TGGCGATTAC AGCCAAAGCA 4901AAATCCGAGC CGACCATGCT TCGGTAACCG AGCAAAGCGG TATTTATGCC 4951GGAGAAGACG GCTATCAAAT CAAGGTCGGA AACCATACAG GCCTCAAAGG 5001CGGCATCATC ACCAGCAGCC AAAGCGCAAA AGACAAGGGT AAAAACCGAT 5051TCAGCACAGG CACACTCGCC GGCAGTGATA TTCAAAATTA CAGCCAATAC 5101GAAGGAAAAA GTTTTGGATT GGGTGCCAGC GTTGCCGTAA GCGGCAAAAC 5151ACTGGGACAG GGCGCAAAAA ATAAACCTCA AGACAAACAC CTGACAAGCA 5201TAGCCGATAA AAACGGCGCA AGTTCATCAG TAGGGTACGG CAGCGACAGC 5251GACAGTCAAA GCAGCATCAC AAAAAGCGGC ATCAATACCC CCAAAAACAT 5301TCAAATCACA GACGAAGCCG CACAAATCAG GCTGACAGGC AAAATAGCGG 5351CACAAACCAA AGCCGATATT GATACAAACG TAACCACAGA CACCGCCGAA 5401CGACATTCGG GCAGCCTGAA AAACATATTT GACAAAGATA GAGTGCAAAG 5451TGAACTGGAT TTACAAAgaA CCGTCAGCCA AGATTTTAGT AAAAATGTTC 5501AACAAACCAA TACCGAGATT AACCAACATT TAGACAAACT CAAAGCAGAC 5551AAAGAAGCAG CCGAAACAGC AGCAGCCGAG GCATTAGCCA ATGGCGATAT 5601GGAAACTGCC AAACGCAAAG CCCATGAAGC TCAAGATGCG GCAGCAAAAG 5651CAGATAATTG GCAACAAGGC AAAGTCATTC TCAACATGTT AGCCTCAGGT 5701TTAGCTGAGC CGACCCAAAG CGGAGCgggc ATCGCTGCGG CTACCGCATC 5751GCCagaCGTA TCGTATGCGA TTGGACAGCA CTTTAAagaT TTAGCCGGTC 5801AAAACGCGAA TGGCAAACTA ACCGCCAGTC AagaAACCGC TCACGTTCTT 5851GCCCACGCGG TATTAGGAGC AGCGGTTGCC GCAGCATGAG GCAACAATGC 5901CCCGGCAGGA GCATTGGGTG CGGGCGGGTc ggAagcggCC GCCCCAATCA 5951TCGGCAAATG GCTGTACGGC AAAGGAGAcg gcggcagccT GAATgcggag 6001gaaaAAGaga CCGTTTCGGC GATTACAAGG ATGCTGggta cGgctGCCGG 6051AGCAGCTGAG GGAAACTCGT CCGCCGATGC TGTGTGGGGT TGTTTTcaaa 6101cggctTCaga TTTCGCTTCC TCTTTTTCAT ATCCTATAAA CATGTGAThis corresponds to the amino acid sequence <SEQ ID 1666; ORF 563.ng>:

g563.pep.. 1 MNKTLYRVIF NRKRGAVVAV AETTKREGKS CADSGSGSVY VKSVSFIPTH 51SKAPFCFSALG FSLCLALGTV NIAFADGIIT DKAAPKTQQA TILQTGNGIP 101 QVNIQTPTSAGVSVNQYAQF DVGNRGAILN NSRSNTQTQL GGWIQGNPWL 151 TRGEARVVVN QINSSHPSQLNGYIEVGGRR AEVVIANPAG IAVNGGGFIN 201 ASRATLTTGQ PQYQAGDFSG FKIRQGNAVIAGHGLDARDT DFTRILLYAN 251 KITLISTAEQ AGIRNQGQLF ASSGNVAIDA NGRLVNSGTMAAANVQDMNN 301 TAEHKVNIRS QAFENSGTAV SQQGTQIHSQ SIQNTGKLLS AGTEDLAVSG351 SLNNQNGEIA TNQQLIIHDG QQSTVVIDNT NGTIQSGRDV AIQAKSLSNN 401GTLAADNKLD IALQDDFYVE RKIVAGNELS LSTRGSLKNS HTLQAGKRIR 451 IKANNLDNAVQGNIQSGGTT DIGTQHNLTN RGLIDGQQTK IQAGQMNNIG 501 TGRIYGDNIA IAATRLDNQDENGTGAAIAA RENLNLGIEQ LNNRENSLIY 551 SGNDMAVGGA LDTNDQATGK AQRIHNAGAIIEAAGKMRLG VEKLHNTNEH 601 LKTQLVETGR ERIVDYEAFG RHELLREGTQ HELGWFVYNNESDHLRTPDG 651 VAHENWHKYD YEKVTQETQV TGTAPAKIIA GSDLIIDSKA VFNSDSRIIA701 GGQLLVQTEK DGLHNEQTFG EKKVFSENGK LHNYWRARRK GHDETGHREQ 751NYTLPEEITR DISLGSFAYE SHSKALSRHA PSQGTELPQS NRDNIRTAKS 801 NGISLPYTPNSFTPLPGSSL YIINPANKGY LVETDPRFAN YRQWLGSDYM 851 LGSLKLDPNN LHKRLGDGYYEQRLINEQIA ELTGHRRLDG YQNDEEQFKA 901 LMDNGATAAR SMNLSVGIAL SAEQAAQLTSDIVWLVQKEV KLPDGGTQTV 951 LMPQVYVRVK NGGIDGKGAL LSGSNTQINV SGSLKNSGTIAGRNALIINT 1001 DTLDNIGGRI HAQKSAVTAT QDINNIGGIL SAEQTLLLNA GNNINNQSTA1051 KSSQNAQGSS TYLDRMAGIY ITGKEKGVLA AQAGKDINII AGQISNQSDQ 1101GQTRLQAGRD INLDTVQTGK YQEIHFDADN HTIRGSTNEV GSSIQTKGDV 1151 TLLSGNNLNAKAAEVGSAKG TLAVYAKNDI TISSGIHAGQ VDDASKHTGR 1201 SGGGNKLVIT DKAQSHHETAQSSTFEGKQV VLQAGNDANI LGSNVISDNG 1251 TRIQAGNHVR IGTTQTQSQS ETYHQTQKSGLMSAGIGFTI GSKTNTQENQ 1301 SQSNEHTGST VGSLKGDTTI VASKHYEQTG SNVSSPEGNNLISTQSMDIG 1351 AAQNQLNSKT TQTYEQKGLT VGIQFARYRF GTTSDCRSTQ SSKQVGQSKN1401 DRVNAMAAAN AGWQAYQTGK GAQNLANGTT NAKQVSISIT YGEQQNRQTT 1451QVQANQAQAS QIQAGGKTTL YCRRCGEQSN INITGSGVSG RAGTGLIADK 1501 QIHLQSAEQSNTERSQNKSA GWNAGAAVSF GQGGWSLGVA AGGNVGKGYG 1551 YGDSVTHRHS HIGDKGSQTLIQSGGDTIIK GAQVRGKGVQ VNAKNLSIQS 1601 VQDRETYQSK QQNAGAQVTV GYGFSASGDYSQSKIRADHA SVTEQSGIYA 1651 GEDGYQIKVG NHTGLKGGII TSSQSAKDKG KNRFSTGTLAGSDIQNYSQY 1701 EGKSFGLGAS VAVSGKTLGQ GAKNKPQDKH LTSIADKNGA SSSVGYGSDS1751 DSQSSITKSG INTPKNIQIT DEAAQIRLTG KIAAQTKADI DTNVTTDTAE 1801RHSGSLKNIF DKDRVQSELD LQRTVSQDFS KNVQQTNTEI NQHLDKLKAD 1851 KEAAETAAAEALANGDMETA KRKAHEAQDA AAKADNWQQG KVILNMLASG 1901 LAEPTQSGAG IAAATASPDVSYAIGQHFKD LAGQNANGKL TASQETAHVL 1951 AHAVLGAAVA AAXGNNAPAG ALGAGGSEAAAPIIGKWLYG KGDGGSLNAE 2001 EKETVSAITR MLGTAAGAAE GNSSADAVWG CFQTASDFASSFSYPINM*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1667>:

m563.seq.. 1 ATGAATAAAA CTCTCTATCG TGTAATTTTC AACCGCAAAC GTGGGGCTGT 51GGTAGCCGTT GCTGAAACTA CCAAGCGCGA AGGTAAAAGC TGTGCCGATA 101 GTGATTCAGGCAGCGCTCAT GTGAAATCTG TTCCTTTTGG TACTACTCAT 151 GCACCTGTTT GTCGTTCAAATATCTTTTCT TTTTCTTTAT TGGGCTTTTC 201 TTTATGTTTG GCTGTAGGTA CGGCCAATATTGCTTTTGCT GATGGCATTA 251 TTGCTGATAA AGCTGCTCCT AAAACTCAAC AAGCCACGATTCTGCAAACA 301 GGTAACGGCA TACCGCAAGT CAATATTCAA ACCCCTACTT CGGCAGGGGT351 TTCTGTTAAT CAATACGCCC AGTTTGATGT GGGTAATCGC GGGGCGATTT 401TAAACAACAG CCGCAGCAAC ACCCAAACAC AGCTAGGCGG TTGGATTCAA 451 GGTAATCCTTGGTTGGCAAG GGGCGAAGCA CGTGTGGTTG TAAACCAAAT 501 CAACAGCAGC CATTCTTCACAAATGAATGG CTATATTGAA GTGGGCGGAC 551 GACGTGCAGA AGTCGTTATT GCCAATCCGGCAGGGATTGC AGTCAATGGT 601 GGTGGTTTTA TCAATGCTTC CCGTGCCACT TTGACGACAGGCCAACCGCA 651 ATATCAAGCA GGAGACCTTA GCGGCTTTAA GATAAGGCAA GGCAATGTTG701 TAATCGCCGG ACACGGTTTG GATGCCCGTG ATACCGATTT CACACGTATT 751CTCAGTTATC ATTCCAAAAT TGATGCACCC GTATGGGGAC AAGATGTTCG 801 TGTCGTCGCGGGACAAAACG ATGTGGTCGC AACAGGTAAT GCACATTCGC 851 CTATTCTCAA TAATGCTGCTGCCAATACGT CAAACAATAC AGCCAACAAC 901 GGCACACATA TCCCTTTATT TGCGATTGATACAGGCAAAT TAGGAGGTAT 951 GTATGCCAAC AAAATCACCT TGATCAGTAC GGCCGAGCAAGCAGGCATTC 1001 GTAATCAAGG GCAGTTGTTT GCTTCTTCCG GTAATGTGGC GATTGATGCA1051 AATGGCCGTT TAGTCAATAG TGGCACGATG GCTGCCGCCA ATGCGAAAGA 1101TACGGATAAT ACAGCGGAAC ACAAAGTCAA TATCCGCAGT CAGGGCGTTG 1151 AAAACAGCGGTACGGCGGTA TCGCAACAAG GCACTCAAAT TCACAGTCAG 1201 TCGATTCAAA ACACTGGCACATTATTGTCC TCAGGCGAAA TATTGATTCA 1251 CAATTCGGGC AGCCTGAAAA ATGAAACATCAGGCACCATT GAAGCCGCTC 1301 GTTTGGCTAT TGATACCGAC ACACTTAATA ATCAAGGCAAACTCTCTCAA 1351 ACAGGTTCAC AAAAACTCCA TATTGATGCA CAAGGCAAAA TGGATAACCG1401 TGGCCGCATG GGTTTACAAG ATACCGCACC AACCGCGTCA AATGGTTCAA 1451GCAATCAAAC CGGCAATAGT TACAATGCAT CTTTCCATTC ATCCACTACC 1501 ACACCAACAACGGCAACAGG TACGGGTACT GCAACCGTTT CTATATCAAA 1551 CATAACTGCG CCTACCTTTGCTGATGGGAC AATTCGCACT CATGGTGCAC 1601 TGGATAATTC AGGCAGTATT ATTGCCAATGGTCAAACAGA TGTTAGTGCG 1651 CAACAAGGTT TAAATAATGC AGGACAAATA GACATTCATCAGTTAAATGC 1701 AAAAGGTTCG GCGTTTGACA ATCACAATGG AACAATTATC AGTGATGCGG1751 TCCACATTCA AGCCGGCAGC CTGAATAATC AAAATGGCAA CATCACAACA 1801CGCCAACAGT TAGAGATTGA AACCGATCAA CTGGATAACG CTCATGGCAA 1851 GTTATTATCAGCAGAAATAG CGGATTTAGC CGTTTCAGGC AGCCTGAACA 1901 ATCAAAATGG CGAAATAGCGACCAATCAAC AACTGATTAT TCACGATGGT 1951 CAGCAATCTA CCGCTGTCAT TGATAATACGAATGGCACGA TACAATCAGG 2001 CCGTGATGTT GCTATTCAGG CAAAATCGTT ATCCAACAACGGCACACTTG 2051 CCGCTGATAA TAAACTGGAT ATTGCGTTAC AAGATGATTT TTATGTAGAA2101 CGCAATATCG TGGCGGGCAA TGAATTGTCG CTCAGTACAC GAGGCAGCCT 2151GAAAAATTCA CATACTTTGC AAGCAGGAAA ACGCATTCGG ATTAAAGCAA 2201 ATAACCTTGATAATGCAGCA CAAGGCAACA TTCAATCCGG CGGTACGACA 2251 GACATTGGCA CGCAGCACAATTTAACCAAT AGAGGCTTGA TTGACGGACA 2301 ACAAACCAAA ATCCAAGCCG GGCAAATGAATAATATCGGT ACAGGTCGGA 2351 TTTATGGCGA CAATATCGCT ATTGCGGCTA CCCGCTTAGACAATCAAGAT 2401 GAAAACGGTA CAGGTGCCGC CATTGCGGCA CGTGAAAACC TGAATTTAGG2451 CATCGGACAA TTAAACAACC GTGAAAACAG TCTGATTTAC AGCGGTAACG 2501ATATGGCGGT TGGCGGCGCA TTAGATACCA ATGGCCAAGC CACAGGCAAA 2551 GCCCAAAGGATACACAATGC CGGCGCAACC ATTGAAGCTG CAGGCAAAAT 2601 GCGTTTAGGT GTAGAAAAGCTGCACAATAC CAATGAGCAT TTGAAAACGC 2651 AGTTGGTAGA AACAGGGCGC GAGCATATTGTTGATTACGA AGCATTTGGA 2701 CGACACGAAT TATTGCGAGA AGGCACGCAA CATGAATTAGGCTGGTCTGT 2751 CTATAACGAT GAATCAGACC ACTTACGCAC CCCTGATGGA GCGGCGCATG2801 AAAATTGGCA TAAATACGAT TATGAAAAAG TCACCCAAAA AACCCAAGTT 2851ACCCAAACTG CGCCAGCCAA AATCATTTCA GGTAATGATT TAACCATTGA 2901 TGGTAAAGAAGTATTTAATA CCGATAGCCA AATCATTGCT GGTGGCAATC 2951 TCATTGTACA AACAGAAAAAGACGGTTTGC ATAACGAGCA AACCTTTGGC 3001 GAAAAGAAAG TATTCAGTGA AAATGGCAAATTACACAGCT ATTGGCGTGA 3051 GAAACATAAA GGACGAGACT CAACGGGACA TAGCGAACAAAATTACACTT 3101 TGCCGGAGGA AATCACACGC AACATTTCAC TGGGTTCATT TGCCTATGAA3151 TCGCATCGCA AAGCATTAAG CCATCATGCG CCCAGCCAAG GCACTGAGTT 3201GCCGCAAAGC AACGGTATTT CGCTACCCTA TACGTCCAAT TCTTTTACCC 3251 CATTACCCAGCAGCAGCTTA TACATTATCA ATCCTGTCAA TAAAGGCTAT 3301 CTTGTTGAAA CCGATCCACGCTTTGCCAAC TACCGTCAAT GGTTGGGTAG 3351 TGACTATATG CTGGACAGCC TCAAACTAGACCCAAACAAT TTACATAAAC 3401 GTTTGGGTGA TGGTTATTAC GAGCAACGTT TAATCAATGAACAAATCGCA 3451 GAGCTGACAG GGCATCGTCG TTTAGACGGT TATCAAAACG ACGAAGAACA3501 ATTTAAAGCC TTAATGGATA ATGGCGCGAC TGCGGCACGT TCGATGAATC 3551TCAGCGTTGG CATTGCATTA AGTGCCGAGC AAGTAGCGCA ACTGACCAGC 3601 GATATTGTTTGGTTGGTACA AAAAGAAGTT AAGCTTCCTG ATGGCGGCAC 3651 ACAAACCGTA TTGGTGCCACAGGTTTATGT ACGCGTTAAA AATGGCGACA 3701 TAGACGGTAA AGGTGCATTG TTGTCAGGCAGCAATACACA AATCAATGTT 3751 TCAGGCAGCC TGAAAAACTC AGGCACGATT GCAGGGCGCAATGCGCTTAT 3801 TATCAATACC GATACGCTAG ACAATATCGG TGGGCGTATT CATGCGCAAA3851 AATCAGCGGT TACGGCCACA CAAGACATCA ATAATATTGG CGGCATGCTT 3901TCTGCCGAAC AGACATTATT GCTCAACGCA GGCAACAACA TCAACAGCCA 3951 AAGCACCACCGCCAGCAGTC AAAATACACA AGGCAGCAGC ACCTACCTAG 4001 ACCGAATGGC AGGTATTTATATCACAGGCA AAGAAAAAGG TGTTTTAGCA 4051 GCGCAGGCAG GAAAAGACAT CAACATCATTGCCGGTCAAA TCAGCAATCA 4101 ATCAGAGCAA GGGCAAACCC GGCTGCAAGC AGGGCGCGACATTAACCTAG 4151 ATACGGTACA AACCAGCAAA CATCAAGCAA CCCATTTTGA TGCCGATAAC4201 CATGTTATTC GCGGTTCAAC GAACGAAGTC GGCAGCAGCA TTCAAACAAA 4251AGGCGATGTT ACCCTATTGT CAGGGAATAA CCTCAATGCC AAAGCTGCCG 4301 AAGTCAGCAGCGCAAACGGT ACACTCGCTG TGTCTGCCAA AAATGACATC 4351 AACATCAGCG CAGGCATCAACACGACCCAT GTTGATGATG CGTCCAAACA 4401 CACAGGCAGA AGCGGTGGTG GCAATAAATTAGTCATTACC GATAAAGCCC 4451 AAAGTCATCA CGAAACCGCC CAAAGCAGCA CCTTTGAAGGCAAGCAAGTT 4501 GTATTGCAGG CAGGAAACGA TGCCAACATC CTTGGCAGCA ATGTTATTTC4551 CGATAATGGC ACCCAGATTC AAGCAGGCAA TCATGTTCGC ATTGGTACAA 4601CCCAAACTCA AAGCCAAAGC GAAACCTATC ATCAAACCCA GAAATCAGGA 4651 TTGATGAGTGCAGGTATCGG CTTCACTATT GGCAGCAAGA CAAACACACA 4701 AGAAAACCAA TCCCAAAGCAACGAACATAC AGGCAGTACC GTAGGCAGCT 4751 TGAAAGGCGA TACCACCATT GTTGCAGGCAAACACTACGA ACAAATCGGC 4801 AGTACCGTTT CCAGCCCGGA AGGCAACAAT ACCATCTATGCCCAAAGCAT 4851 AGACATTCAA GCGGCACACA ACAAATTAAA CAGTAATACC ACCCAAACCT4901 ATGAACAAAA AGGCCTAACG GTGGCATTCA GTTCGCCCGT TACCGATTTG 4951GCACAACAAG CGATTGCCGT AGCACAAAGC AGCAAACAAG TCGGACAAAG 5001 CAAAAACGACCGCGTTAATG CCATGGCGGC TGCCAATGCA GGCTGGCAAG 5051 CCTATCAAAC AGGTAAGAGTGCACAAAACT TAGCCAATGG TACAACCAAT 5101 GCCAAACAAG TCAGCATCTC CATAACCTACGGCGAACAGC AAAACCGACA 5151 AACCACCCAA GTTCAAGCCA ATCAAGCCCA AGCGAGTCAAATTCAAGCAG 5201 GTGGTAAAAC CACATTAATC GCCACAGGCG CAGCAGAACA ATCCAATATC5251 AACATCGCAG GCTCAGATGT TGCCGGCAAA GCAGGCACAA TCCTGATTGC 5301CGATAACGAC ATCACACTCC AATCAGCCGA GCAAAGCAAT ACCGAACGCG 5351 GCCAAAACAAATCGGCAGGC TGGAACGCAG GTGCTGCCGT ATCATTCGGA 5401 CAAGGAGGCT GGTCATTAGGCGTTACCGCA GGCGGCAATG TCGGCAAAGG 5451 CTACGGCAAT GGCGACAGCA TCACCCACCGCCATAGCCAT ATCGGCGACA 5501 AAGGCAGCCA AACCCTTATC CAAAGCGGTG GCGACACTACCATCAAAGGC 5551 GCGCAAGTAC GCGGCAAAGG CGTACAAGTC AATGCCAAAA ACCTAAGTAT5601 TCAAAGCGTA CAAGATAGAG AAACCTATCA AAGCAAACAA CAAAACGCCA 5651GTGCACAAGT TACCGTAGGT TATGGCTTCA GTGCCGGTGG CGATTACAGC 5701 CAAAGCAAAATCCGAGCCGA CCATGTTTCA GTAACCGAGC AAAGCGGTAT 5751 TTATGCCGGA GAAGACGGCTATCAAATCAA GGTCGGAAAC CATACAGACC 5801 TCAAAGGCGG CATCATCACC AGTACCCAAAGCGCAGAAGA CAAGGGTAAA 5851 AACCGCTTTC AGACGGCCAC CCTCACCCAT AGCGACATCAAAAACCACAG 5901 CCAATACAAA GGCGAAAGTT TTGGATTGGG CGCAAGTGCG TCCATAAGCG5951 GCAAAACACT GGGACAGGGC GCACAAAATA AACCTCAAAA CAAACACCTG 6001ACAAGCGTAG CCGATAAAAA CAGCGCAAGT TCATCAGTGG GTTATGGCAG 6051 CGACAGCGACAGTCAAAGCA GCATCACAAA AAGCGGCATC AACACCCGCA 6101 ACATTCAAAT CACCGACGAAGCCGCACAAA TCCGGCTGAC AGGCAAAACA 6151 GCGGCACAAA CCAAAGCCGA TATTGATACAAACGTAACCA CAGACACCGC 6201 CGAACGACAT TCGGGCAGCT TGAAGAACAC CTTCAACAAAGAAGCGGTGC 6251 AAAGTGAACT GGATTTACAA AGAACCGTCA GCCAAGATTT TAGTAAAAAT6301 GTTCAACAAG CCAATACCGA GATTAACCAA CATTTAGACA AACTCAAAGC 6351AGACAAAGAA GCAGCCGAAA CAGCAGCAGC CGAGGCATTA GCCAATGGCG 6401 ATATGGAAACTGCCAAACGC AAAGCCCATG AAGCTCAAGA TGCGGCAGCA 6451 AAAGCAGATA ATTGGCAACAAGGCAAAGTC ATTCTCAACA TGTTAGCCTC 6501 AGGTTTAGCT GCGCCGACCC AAAGCGGAGCGGGCATCGCT GCGGCTACCG 6551 CATCGCCAGC CGTATCGTAT GCGATTGGAC AGCACTTTAAAGATTTAGCC 6601 GGTCAAAACG CGAATGGTAA ACTAACCGCC AGTCAAGAAA CCGCACACGT6651 TCTTGCCCAC GCGGTATTAG GAGCAGCGGT TGCCGCAGTA GGAGACAACA 6701ATGCTCTAGC AGGAGCATTG AGTGCGGGCG GGTCGGAAGC GGCTGCGCCT 6751 TACATCAGCAAATGGTTATA CGGCAAAGAA AAAGGAAGCG ACTTAACGGC 6801 GGAAGAGAAA GAGACTGTAACAGCGATTAC AAATGTATTG GGTACGGCTA 6851 CGGGTGCGGC AGTCGGCAAC AGCGCAACAGATGCAGCGCA AGGCAGCCTG 6901 AATGCGCAAA GTGCGGTGGA GAATAATGAT ACTGTAGAGCAAGTGAAATT 6951 TGCTCTTAGG CACCCTAGAA TTGCTATTGC AATTGGATCT GTACATAAAG7001 ATCCTGGCTC TACATTAGAG CCTAATATTT CAACAATTGC TTCAACTTTT 7051CAATTAAATT TATTTCCTAA TAGTGAATTT GGTGGTGAAG GTGGAGTTGG 7101 CAATGCATTCAGGCACGTTT TATGGCAAGC AACCATCACA CGAGAATTTG 7151 GCAAAGATAT TGCTGTTAAAGTAGGAAATA GTCATGAAAG TGGGGAAAAA 7201 ATTAATTATT CTATAAGACG TAATCTTTCATTAGATAAAG CAGATGAAAT 7251 GATTGATCAA CTAAATAACG AAATAGGAAG AGAAATAGCATTAAATACCA 7301 ATAGGTTAAA CACAAAAGAG TTAGTTGGAT TAATTCTGGA AACTTATAAA7351 AATAATGGTT TTTATCAAGC AGAAAGAAAC AGTAATGGAA ATTATGATGT 7401TGTAAGAAAA AGATTATCTG AAAAAGATTA CCAGAATACA AGCAATATAT 7451 TGATTCACTTAGATAATACT GGTGCCGGAT TTAAAATTCA GCAGAGGAGA 7501 AAACAAATCA GAGCACAAATTTCAGCCAGA CAATGGAGAA GATAAThis corresponds to the amino acid sequence <SEQ ID 1668; ORF 563>:

m563.pep.. 1 MNKTLYRVIF NRKRGAVVAV AETTKREGKS CADSDSGSAH VKSVPFGTTH 51APVCRSNIFS FSLLGFSLCL AVGTANIAFA DGIIADKAAP KTQQATILQT 101 GNGIPQVNIQTPTSAGVSVN QYAQFDVGNR GAILNNSRSN TQTQLGGWIQ 151 GNPWLARGEA RVVVNQINSSHSSQMNGYIE VGGRRAEVVI ANPAGIAVNG 201 GGFINASRAT LTTGQPQYQA GDLSGFKIRQGNVVIAGHGL DARDTDFTRI 251 LSYHSKIDAP VWGQDVRVVA GQNDVVATGN AHSPILNNAAANTSNNTANN 301 GTHIPLFAID TGKLGGMYAN KITLISTAEQ AGIRNQGQLF ASSGNVAIDA351 NGRLVNSGTM AAANAKDTDN TAEHKVNIRS QGVENSGTAV SQQGTQIHSQ 401SIQNTGTLLS SGEILIHNSG SLKNETSGTI EAARLAIDTD TLNNQGKLSQ 451 TGSQKLHIDAQGKMDNRGRM GLQDTAPTAS NGSSNQTGNS YNASFHSSTT 501 TPTTATGTGT ATVSISNITAPTFADGTIRT HGALDNSGSI IANGQTDVSA 551 QQGLNNAGQI DIHQLNAKGS AFDNHNGTIISDAVHIQAGS LNNQNGNITT 601 RQQLEIETDQ LDNAHGKLLS AEIADLAVSG SLNNQNGEIATNQQLIIHDG 651 QQSTAVIDNT NGTIQSGRDV AIQAKSLSNN GTLAADNKLD IALQDDFYVE701 RNIVAGNELS LSTRGSLKNS HTLQAGKRIR IKANNLDNAA QGNIQSGGTT 751DIGTQHNLTN RGLIDGQQTK IQAGQMNNIG TGRIYGDNIA IAATRLDNQD 801 ENGTGAAIAARENLNLGIGQ LNNRENSLIY SGNDMAVGGA LDTNGQATGK 851 AQRIHNAGAT IEAAGKMRLGVEKLHNTNEH LKTQLVETGR EHIVDYEAFG 901 RHELLREGTQ HELGWSVYND ESDHLRTPDGAAHENWHKYD YEKVTQKTQV 951 TQTAPAKIIS GNDLTIDGKE VFNTDSQIIA GGNLIVQTEKDGLHNEQTFG 1001 EKKVFSENGK LHSYWREKHK GRDSTGHSEQ NYTLPEEITR NISLGSFAYE1051 SHRKALSHHA PSQGTELPQS NGISLPYTSN SFTPLPSSSL YIINPVNKGY 1101LVETDPRFAN YRQWLGSDYM LDSLKLDPNN LHKRLGDGYY EQRLINEQIA 1151 ELTGHRRLDGYQNDEEQFKA LMDNGATAAR SMNLSVGIAL SAEQVAQLTS 1201 DIVWLVQKEV KLPDGGTQTVLVPQVYVRVK NGDIDGKGAL LSGSNTQINV 1251 SGSLKNSGTI AGRNALIINT DTLDNIGGRIHAQKSAVTAT QDINNIGGML 1301 SAEQTLLLNA GNNINSQSTT ASSQNTQGSS TYLDRMAGIYITGKEKGVLA 1351 AQAGKDINII AGQISNQSEQ GQTRLQAGRD INLDTVQTSK HQATHFDADN1401 HVIRGSTNEV GSSIQTKGDV TLLSGNNLNA KAAEVSSANG TLAVSAKNDI 1451NISAGINTTH VDDASKHTGR SGGGNKLVIT DKAQSHHETA QSSTFEGKQV 1501 VLQAGNDANILGSNVISDNG TQIQAGNHVR IGTTQTQSQS ETYHQTQKSG 1551 LMSAGIGFTI GSKTNTQENQSQSNEHTGST VGSLKGDTTI VAGKHYEQIG 1601 STVSSPEGNN TIYAQSIDIQ AAHNKLNSNTTQTYEQKGLT VAFSSPVTDL 1651 AQQAIAVAQS SKQVGQSKND RVNAMAAANA GWQAYQTGKSAQNLANGTTN 1701 AKQVSISITY GEQQNRQTTQ VQANQAQASQ IQAGGKTTLI ATGAAEQSNI1751 NIAGSDVAGK AGTILIADND ITLQSAEQSN TERGQNKSAG WNAGAAVSFG 1801QGGWSLGVTA GGNVGKGYGN GDSITHRHSH IGDKGSQTLI QSGGDTTIKG 1851 AQVRGKGVQVNAKNLSIQSV QDRETYQSKQ QNASAQVTVG YGFSAGGDYS 1901 QSKIRADHVS VTEQSGIYAGEDGYQIKVGN HTDLKGGIIT STQSAEDKGK 1951 NRFQTATLTH SDIKNHSQYK GESFGLGASASISGKTLGQG AQNKPQNKHL 2001 TSVADKNSAS SSVGYGSDSD SQSSITKSGI NTRNIQITDEAAQIRLTGKT 2051 AAQTKADIDT NVTTDTAERH SGSLKNTFNK EAVQSELDLQ RTVSQDFSKN2101 VQQANTEINQ HLDKLKADKE AAETAAAEAL ANGDMETAKR KAHEAQDAAA 2151KADNWQQGKV ILNMLASGLA APTQSGAGIA AATASPAVSY AIGQHFKDLA 2201GQNANGKLTA SQETAHVLAH AVLGAAVAAV GDNNALAGAL SAGGSEAAAP 2251 YISKWLYGKEKGSDLTAEEK ETVTAITNVL GTATGAAVGN SATDAAQGSL 2301 NAQSAVENND TVEQVKFALRHPRIAIAIGS VHKDPGSTLE PNISTIASTF 2351 QLNLFPNSEF GGEGGVGNAF RHVLWQATITREFGKDIAVK VGNSHESGEK 2401 INYSIRRNLS LDKADEMIDQ LNNEIGREIA LNTNRLNTKELVGLILETYK 2451 NNGFYQAERN SNGNYDVVRK RLSEKDYQNT SNILIHLDNT GAGFKIQQRR2501 KQIRAQISAR QWRR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeae ORF 563 shows 79.1%identity over a 2316 aa overlap with a predicted ORF (ORF 563.ng) fromN. gonorrhoeae:

m563/g563            10        20        30        40        50 g563.pep   MNKTLYRVIFNRKRGAVVAVAETTKREGKSCADSGSGSVYVKSVSFIPTH-----SKAFC   |||||||||||||||||||||||||||||||||| |||::|||| |  ||     |: | m563.pep   MNKTLYRVIFNRKRGAVVAVAETTKREGKSCADSDSGSAHVKSVPFGTTHAPVCRSNIFS           10        20        30        40        50        60      60        70        80        90       100       110 g563.pep   FSALGFSLCLALGTVNIAFADGIITDKAAPKTQQATILQTGNGIPQVNIQTPTSAGVSVN   || ||||||||:||:|||||||||:||||||||||||||||||||||||||||||||||| m563.pep   FSLLGFSLCLAVGTANIAFADGIIADKAAPKTQQATILQTGNGIPQVNIQTPTSAGVSVN           70        80        90       100       110       120     120       130       140       150       160       170 g563.pep   QYAQFDVGNRGAILNNSRSNTQTQLGGWIQGNPWLTRGEARVVVNQINSSHPSQLNGYIE   |||||||||||||||||||||||||||||||||||:||||||||||||||| ||:||||| m563.pep   QYAQFDVGNRGAILNNSRSNTQTQLGGWIQGNPWLARGEARVVVNQINSSHSSQMNGYIE          130       140       150       160       170       180     180       190       200       210       220       230 g563.pep   VGGRRAEVVIANPAGIAVNGGGFINASRATLTTGQPQYQAGDFSGFKIRQGNAVIAGHGL   ||||||||||||||||||||||||||||||||||||||||||:|||||||||:||||||| m563.pep   VGGRRAEVVIANPAGIAVNGGGFINASRATLTTGQPQYQAGDLSGFKIRQGNVVIAGHGL          190       200       210       220       230       240      240g563.pep    DARDTDFTRIL-------------------------------------------------   ||||||||||| m563.pep   DARDTDFTRILSYHSKIDAPVWGQDVRVVAGQNDVVATGNAHSPILNNAAANTSNNTANN          250       260       270       280       290       300                    250       260       270       280       290 g563.pep   ----------------LYANKITLISTAEQAGIRNQGQLFASSGNVAIDANGRLVNSGTM                   :||||||||||||||||||||||||||||||||||||||||||| m563.pep   GTHIPLFAIDTGKLGGMYANKITLISTAEQAGIRNQGQLFASSGNVAIDANGRLVNSGTM          310       320       330       340       350       360          300       310       320       330       340 g563.pep   AAANVQDMNNTAEHKVNIRSQAFENSGTAVSQQGTQIHSQSIQNTGKLLSAGT-------   ||||::| :||||||||||||: ||||||||||||||||||||||| |||:| m563.pep   AAANAKDTDNTAEHKVNIRSQGVENSGTAVSQQGTQIHSQSIQNTGTLLSSGEILIHNSG          370       380       390       400       410       420 g563.pep   ------------------------------------------------------------ m563.pep    SLKNETSGTIEAARLAIDTDTLNNQGKLSQTGSQKLHIDAQGKMDNRGRMGLQDTAPTAS          430       440       450       460       470       480 g563.pep   ------------------------------------------------------------ m563.pep    NGSSNQTGNSYNASFHSSTTTPTTATGTGTATVSISNITAPTFADGTIRTHGALDNSGSI          490       500       510       520       530       540 g563.pep   ------------------------------------------------------------ m563.pep    IANGQTDVSAQQGLNNAGQIDIHQLNAKGSAFDNHNGTIISDAVHIQAGSLNNQNGNITT          550       560       570       580       590       600                              350       360       370       380 g563.pep   -----------------------EDLAVSGSLNNQNGEIATNQQLIIHDGQQSTVVIDNT                           ||||||||||||||||||||||||||||||:||||| m563.pep   RQQLEIETDQLDNAHGKLLSAEIADLAVSGSLNNQNGEIATNQQLIIHDGQQSTAVIDNT          610       620       630       640       650       660          390       400       410       420       430       440 g563.pep   NGTIQSGRDVAIQAKSLSNNGTLAADNKLDIALQDDFYVERKIVAGNELSLSTRGSLKNS   |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| m563.pep   NGTIQSGRDVAIQAKSLSNNGTLAADNKLDIALQDDFYVERNIVAGNELSLSTRGSLKNS          670       680       690       700       710       720          450       460       470       480       490       500 g563.pep   HTLQAGKRIRIKANNLDNAVQGNIQSGGTTDIGTQHNLTNRGLIDGQQTKIQAGQMNNIG   |||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||| m563.pep   HTLQAGKRIRIKANNLDNAAQGNIQSGGTTDIGTQHNLTNRGLIDGQQTKIQAGQMNNIG          730       740       750       760       770       780          510       520       530       540       550       560 g563.pep   TGRIYGDNIAIAATRLDNQDENGTGAAIAARENLNLGIEQLNNRENSLIYSGNDMAVGGA   |||||||||||||||||||||||||||||||||||||| ||||||||||||||||||||| m563.pep    TGRIYGDNIAIAATRLDNQDENGTGAAIAARENLNLGIGQLNNRENSLIYSGNDMAVGGA          790       800       810       820       830       840          570       580       590       600       610       620 g563.pep   LDTNDQATGKAQRIHNAGAIIEAAGKMRLGVEKLHNTNEHLKTQLVETGRERIVDYEAFG   |||| |||||||||||||| |||||||||||||||||||||||||||||||:|||||||| m563.pep    LDTNGQATGKAQRIHNAGATIEAAGKMRLGVEKLHNTNEHLKTQLVETGREHIVDYEAFG          850       860       870       880       890       900          630       640       650       660       670       680 g563.pep   RHELLREGTQHELGWFVYNNESDHLRTPDGVAHENWHKYDYEKVTQETQVTGTAPAKIIA   ||||||||||||||| |||:||||||||||:|||||||||||||||:|||| |||||||: m563.pep   RHELLREGTQHELGWSVYNDESDHLRTPDGAAHENWHKYDYEKVTQKTQVTQTAPAKIIS          910       920       930       940       950       960          690       700       710       720       730       740 g563.pep   GSDLIIDSKAVFNSDSRIIAGGQLLVQTEKDGLHNEQTFGEKKVFSENGKLHNYWRARRK   |:|| ||:| |||:||:|||||:|:|||||||||||||||||||||||||||:||| ::| m563.pep   GNDLTIDGKEVFNTDSQIIAGGNLIVQTEKDGLHNEQTFGEKKVFSENGKLHSYWREKHK          970       980       990      1000      1010      1020          750       760       770       780       790       800 g563.pep   GHDETGHREQNYTLPEEITRDISLGSFAYESHSKALSRHAPSQGTELPQSNRDNIRTAKS   |:| ||| ||||||||||||:|||||||||| |||||:||||||||||||| m563.pep   GRDSTGHSEQNYTLPEEITRNISLGSFAYESHRKALSHHAPSQGTELPQSN---------         1030      1040      1050      1060      1070          810       820       830       840       850       860 g563.pep   NGISLPYTPNSFTPLPGSSLYIINPANKGYLVETDPRFANYRQWLGSDYMLGSLKLDPNN    ||||||| |||||||:||||||||:|||||||||||||||||||||||| ||||||||| m563.pep   -GISLPYTSNSFTPLPSSSLYIINPVNKGYLVETDPRFANYRQWLGSDYMLDSLKLDPNN         1080      1090      1100      1110      1120      1130          870       880       890       900       910       920 g563.pep   LHKRLGDGYYEQRLINEQIAELTGHRRLDGYQNDEEQFKALMDNGATAARSMNLSVGIAL   |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m563.pep   LHKRLGDGYYEQRLINEQIAELTGHRRLDGYQNDEEQFKALMDNGATAARSMNLSVGIAL         1140      1150      1160      1170      1180      1190          930       940       950       960       970       980 g563.pep   SAEQAAQLTSDIVWLVQKEVKLPDGGTQTVLMPQVYVRVKNGGIDGKGALLSGSNTQINV   ||||:||||||||||||||||||||||||||:|||||||||| ||||||||||||||||| m563.pep   SAEQVAQLTSDIVWLVQKEVKLPDGGTQTVLVPQVYVRVKNGDIDGKGALLSGSNTQINV         1200      1210      1220      1230      1240      1250          990      1000      1010      1020      1030      1040 g563.pep   SGSLKNSGTIAGRNALIINTDTLDNIGGRIHAQKSAVTATQDINNIGGILSAEQTLLLNA   ||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||| m563.pep   SGSLKNSGTIAGRNALIINTDTLDNIGGRIHAQKSAVTATQDINNIGGMLSAEQTLLLNA         1260      1270      1280      1290      1300      1310         1050      1060      1070      1080      1090      1100 g563.pep   GNNINNQSTAKSSQNAQGSSTYLDRMAGIYITGKEKGVLAAQAGKDINIIAGQISNQSDQ   |||||:|||: ||||:||||||||||||||||||||||||||||||||||||||||||:| m563.pep   GNNINSQSTTASSQNTQGSSTYLDRMAGIYITGKEKGVLAAQAGKDINIIAGQISNQSEQ         1320      1330      1340      1350      1360      1370         1110      1120      1130      1140      1150      1160 g563.pep   GQTRLQAGRDINLDTVQTGKYQEIHFDADNHTIRGSTNEVGSSIQTKGDVTLLSGNNLNA   ||||||||||||||||||:|:|  |||||||:|||||||||||||||||||||||||||| m563.pep   GQTRLQAGRDINLDTVQTSKHQATHFDADNHVIRGSTNEVGSSIQTKGDVTLLSGNNLNA         1380      1390      1400      1410      1420      1430         1170      1180      1190      1200      1210      1220 g563.pep   KAAEVGSAKGTLAVYAKNDITISSGIHAGQVDDASKHTGRSGGGNKLVITDKAQSHHETA   |||||:||:||||| |||||:||:||:: :|||||||||||||||||||||||||||||| m563.pep   KAAEVSSANGTLAVSAKNDINISAGINTTHVDDASKHTGRSGGGNKLVITDKAQSHHETA         1440      1450      1460      1470      1480      1490         1230      1240      1250      1260      1270      1280 g563.pep   QSSTFEGKQVVLQAGNDANILGSNVISDNGTRIQAGNHVRIGTTQTQSQSETYHQTQKSG   |||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||| m563.pep   QSSTFEGKQVVLQAGNDANILGSNVISDNGTQIQAGNHVRIGTTQTQSQSETYHQTQKSG         1500      1510      1520      1530      1540      1550         1290      1300      1310      1320      1330      1340 g563.pep   LMSAGIGFTIGSKTNTQENQSQSNEHTGSTVGSLKGDTTIVASKHYEQTGSNVSSPEGNN   ||||||||||||||||||||||||||||||||||||||||||:||||| ||:|||||||| m563.pep   LMSAGIGFTIGSKTNTQENQSQSNEHTGSTVGSLKGDTTIVAGKHYEQIGSTVSSPEGNN         1560      1570      1580      1590      1600      1610         1350      1360      1370      1380      1390      1400 g563.pep   LISTQSMDIGAAQNQLNSKTTQTYEQKGLTVGIQFARYRFGTTSDCRSTQSSKQVGQSKN    | :||:|| ||:|:|||:||||||||||||:::     ::  :    :||||||||||| m563.pep   TIYAQSIDIQAAHNKLNSNTTQTYEQKGLTVAFSSPVTDLAQQA-IAVAQSSKQVGQSKN         1620      1630      1640      1650       1660         1410      1420      1430      1440      1450      1460 g563.pep   DRVNAMAAANAGWQAYQTGKGAQNLANGTTNAKQVSISITYGEQQNRQTTQVQANQAQAS   ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||| m563.pep   DRVNAMAAANAGWQAYQTGKSAQNLANGTTNAKQVSISITYGEQQNRQTTQVQANQAQAS1670      1680      1690      1700      1710      1720         1470      1480      1490      1500      1510      1520 g563.pep   QIQAGGKTTLYCRRCGEQSNINITGSGVSGRAGTGLIADKQIHLQSAEQSNTERSQNKSA   ||||||||||     :|||||||:|| |:|:||| ||||::| |||||||||||:||||| m563.pep    QIQAGGKTTLIATGAAEQSNINIAGSDVAGKAGTILIADNDITLQSAEQSNTERGQNKSA1730      1740      1750      1760      1770      1780         1530      1540      1550      1560      1570      1580 g563.pep   GWNAGAAVSFGQGGWSLGVAAGGNVGKGYGYGDSVTHRHSHIGDKGSQTLIQSGGDTIIK   |||||||||||||||||||:|||||||||| |||:|||||||||||||||||||||| || m563.pep   GWNAGAAVSFGQGGWSLGVTAGGNVGKGYGNGDSITHRHSHIGDKGSQTLIQSGGDTTIK1790      1800      1810      1820      1830      1840         1590      1600      1610      1620      1630      1640 g563.pep   GAQVRGKGVQVNAKNLSIQSVQDRETYQSKQQNAGAQVTVGYGFSASGDYSQSKIRADHA   ||||||||||||||||||||||||||||||||||:|||||||||||:||||||||||||: 563.pep   GAQVRGKGVQVNAKNLSIQSVQDRETYQSKQQNASAQVTVGYGFSAGGDYSQSKIRADHV1850      1860      1870      1880      1890      1900         1650      1660      1670      1680      1690      1700 g563.pep   SVTEQSGIYAGEDGYQIKVGNHTGLKGGIITSSQSAKDKGKNRFSTGTLAGSDIQNYSQY   ||||||||||||||||||||||| ||||||||:|||:|||||||:|:||: |||:|:||| m563.pep   SVTEQSGIYAGEDGYQIKVGNHTDLKGGIITSTQSAEDKGKNRFQTATLTHSDIKNHSQY1910      1920      1930      1940      1950      1960         1710      1720      1730      1740      1750      1760 g563.pep   EGKSFGLGASVAVSGKTLGQGAKNKPQDKHLTSIADKNGASSSVGYGSDSDSQSSITKSG   :|:|||||||:::|||||||||:||||:|||||:||||:||||||||||||||||||||| m563.pep    KGESFGLGASASISGKTLGQGAQNKPQNKHLTSVADKNSASSSVGYGSDSDSQSSITKSG1970      1980      1990      2000      2010      2020         1770      1780      1790      1800      1810      1820 g563.pep   INTPKNIQITDEAAQIRLTGKIAAQTKADIDTNVTTDTAERHSGSLKNIFDKDRVQSELD   ||| :|||||||||||||||| |||||||||||||||||||||||||| |:|: |||||| m563.pep   INT-RNIQITDEAAQIRLTGKTAAQTKADIDTNVTTDTAERHSGSLKNTFNKEAVQSELD2030       2040      2050      2060      2070      2080         1830      1840      1850      1860      1870      1880 g563.pep   LQRTVSQDFSKNVQQTNTEINQHLDKLKADKEAAETAAAEALANGDMETAKRKAHEAQDA   |||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||| m563.pep   LQRTVSQDFSKNVQQANTEINQHLDKLKADKEAAETAAAEALANGDMETAKRKAHEAQDA 2090      2100      2110      2120      2130      2140         1890      1900      1910      1920      1930      1940 g563.pep   AAKADNWQQGKVILNMLASGLAEPTQSGAGIAAATASPDVSYAIGQHFKDLAGQNANGKL   |||||||||||||||||||||| ||||||||||||||| ||||||||||||||||||||| m563.pep   AAKADNWQQGKVILNMLASGLAAPTQSGAGIAAATASPAVSYAIGQHFKDLAGQNANGKL 2150      2160      2170      2180      2190      2200         1950      1960      1970      1980      1990      2000 g563.pep   TASQETAHVLAHAVLGAAVAAAXGNNAPAGALGAGGSEAAAPIIGKWLYGKGDGGSLNAE   |||||||||||||||||||||:  ||| ||||:||||||||| |:||||||  |::|:|| m563.pep   TASQETAHVLAHAVLGAAVAAVGDNNALAGALSAGGSEAAAPYISKWLYGKEKGSDLTAE 2210      2220      2230      2240      2250      2260         2010      2020      2030      2040     2049 g563.pep   EKETVSAITRMLGTAAGAAEGNSSADAVWGCFQTASDFASSFSYPINMX   |||||:||| :||||:||| |||::||: | ::: | m563.pep   EKETVTAITNVLGTATGAAVGNSATDAAQGSLNAQSAVENNDTVEQVKFALRHPRIAIAI 2270      2280      2290      2300      2310      2320 m563.pep   GSVHKDPGSTLEPNISTIASTFQLNLFPNSEFGGEGGVGNAFRHVLWQATITREFGKDIA         2330      2340      2350      2360      2370      2380The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1669>:

m564.seq 1 ATGAACCGCA CCCTGTACAA AGTTGTATTT AACAAACATC GAAACTGCAT 51GATAGCCGTT GCTGAAAATG CCAAACGCGA GGGCAAAAAC ACAGCCGACA 101 CCCAAGCTGTAGGTATTTTG CCAAATGATA TTGCGGGCTT TGCGGGTTTT 151 ATCCATTCTA TCTCTGTTATCTCATTCTCC CTTTCATTAC TGCTCGGTTC 201 TGCCCTTATC CTGACTTCTT CTTCTGCTACTGCCCAAGGT ATCGTTGCCG 251 ACAAATCCGC ACCTGCACAG CAACAGCCTA CCATCCTGCAAACAGGTAAC 301 GGCATACCGC AAGTCAATAT TCAAACCCCT ACTTCGGCAG GGGTTTCTGT351 TAATCAATAC GCCCAGTTTG ATGTGGGTAA TCGCGGGGCG ATTTTAAACA 401ACAGTCGCAG CAACACCCAA ACACAGCTAG GCGGTTGGAT TCAAGGCAAT 451 CCTTGGTTGGCAAGGGGCGA AGCACGTGTG GTTGTAAACC AAATCAACAG 501 CAGCCATTCT TCACAACTGAATGGCTATAT TGAAGTGGGC GGACGACGTG 551 CAGAAGTCGT TATTGCCAAT CCGGCAGGGATTGCAGTCAA TGGTGGTGGT 601 TTTATCAATG CTTCCCGTGC CACTTTGACG ACAGCCCAACCGCAATATCA 651 AGCAGGAGAC CTTAGCGGCT TTAAGATAAG GCAAGGCAAT GTTGTAATCG701 CCGGACACGG TTTGGATGCA CGTGATACCG ATTACACACG TATTCTCAGT 751TATCATTCCA AAATTGATGC ACCCGTATGG GGACAAGATG TTCGTGTCGT 801 CGCGGGACAAAACGATGTGG CCGCAACAGG TGATGCACAT TCGCCTATTC 851 TCAATAATGC TGCTGCCAATACGTCAAACA ATACAGCCAA CAACGGCACA 901 CATATCCCTT TATTTGCGAT TGATACAGGCAAATTAGGAG GTATGTATGC 951 CAACAAAATC ACCTTGATCA GTACGGTCGA GCAAGCAGGCATTCGTAATC 1001 AAGGGCAATG GTTTGCCTCA GCCGGCAATG TGGCAGTGAA TGCTGAGGGT1051 AAACTGGTCA ACACGGGCAT GATTGCAGCG ACGGGAGAAA ATCATGCGGT 1101TTCACTTCAT GCCGGCAATG TTCATAATAG CGGTACGGTT GCCTCACAGG 1151 ATGATGCCAATATTCACAGC CAGACGCTGG ACAATTCAGG TACGGTCTTA 1201 TCCTCAGGTC GATTGACTGTTCGTAATTTA GGCCGTCTGA AAAACCAAAA 1251 CAACGGTACG ATCCAGGCTG CCCGCTTAGATATGTCAACA GGTGGTTTGG 1301 ATAACACAGG TAATATTACT CAAACAGGTT CACAAGCATTGGATTTGGTA 1351 TCTGCCGGCA AATTCGATAA CAGTGGCAAG ATTGGTGTAA GTGACGTTCC1401 ACAGACCGGT TTGAATCCCA ATCCATCAGT CATACCACAG ATTCCGAGTA 1451CTGCAACAGG TTCAGGCAGC AGCACTGTCT CGGTATCTAA GCCTGGTTCA 1501 AACAATCCCGTTTCACCTAC AGCACCTGCA AAAAACTACG CCGTAGGACG 1551 CATTCAAACA ACAGGAGCATTTGACAATGC AGGATCAATT AATGCGGGTG 1601 GGCAAATTGA CATTGCCGCC CAAAACGGTTTGGGAAATTC GGGTAGTCTG 1651 AATGCGGCTA AACTACGAGT ATCAGGCGAT TCATTTAACAATACGGTAAA 1701 AGGCAAACTC CAGGCACACG ATCTGGCTGT TAACACTCAA ACTGCTAAAA1751 ACAGCGGTCA CTTATTAACT CAAACCGGCA AGATTGATAA CCGTGAACTG 1801CATAATGCCG GAGAAATTGC CGCCAACAAT CTGACACTCA TTCATTCGGG 1851 CCGCTTGAGCAATGATAAAA AAGGCAATAT TCGAGCTGCA CATTTACAGC 1901 TTGATACCGC CGGTTTACATAATGCAGGTA ACATTCTTGC CGATAGTGGA 1951 ACCGTTACCA CCAAGAATAA TCTTCGCAATACAGGAAAAG TTTCTGTTGC 2001 ACGACTGAAT ACCGAAGGTC AGACTCTAGA TAATACGCGCGGACGTATAG 2051 AGGCTGAAAC GGTTAACATC CAAAGTCAGC AACTGACTAA CCAAAGCGGC2101 CATATTACTG CTACCGAACA ACTGACTATC AATAGTCGAA ATGTAGACAA 2151CCAAAACGGC AAACTCCTAT CTGCAAACCA AGCACAATTA GCTGTTTCAG 2201 ACGGCCTATACAACCAACAT GGTGAAATTG CCACCAACCG GCAGTTGTCT 2251 ATTCACGATA AAAATCAAAACACTTTGGCG TTAAACAATG CGGATGGCAC 2301 GATTCAATCT GCCGGTAATG TATCGCTACAAGCCAAATCA CTCGCCAACA 2351 ATGGCACATT AACAGCCGGT AACAAACTGG ATATTGCTTTGACGGACGAT 2401 TTCGTCGTAG AGCGCGACCT CACTGCAGGC AAACAATTAA ATCTAAGCAT2451 AAAAGGCCGT CTGAAAAATA CCCATACCCT ACAAGCAGGC CATACGCTCA 2501AACTCAATGC CGGCAATATA GATAACCAAG TTACAGGCAA AATTATTGGT 2551 GGAGAACAAACGGACATCAC ATCCGAACAG CATGTTGACA ACAGGGGCTT 2601 GATCAACAGC GACGGTTTGACCCACATCGG TGCAGGTCAA ACCCTGACCA 2651 ACACCGGGAC AGGCAAAATC TATGGCAACCATATTGCCCT GGACGCGCAA 2701 ATACTGCTTA ACCGGGAAGA AACGACGGAA GGCAGTACCAAAGCGGGGGC 2751 AATAGCTGCA AGGAAACGTT TGGATATTGG AGCGAAAGAG ATTCATAACC2801 AAGAAGGTGC CCTACTATCC AGCGAAGGTA TTTTTGCCGT AgGTAATCGA 2851CTGGATGAAC AACATCATGC GGCAGGCATG GCCGATACCT TTGTTAATGG 2901 CAGTGCCGGTTTGGAAGTAC AAGGTGATGC ATTGATGTCC GTTCGGAATA 2951 TGCAGAATAT CAATAATCACTTTAAAACAG AGACATACTT AGCCAAAGCG 3001 GAAAAGCAAG TCCGCGACTA CACCGTACTGGGGCAAAATA CCTACTATCA 3051 GGCGGGAAAA GACGGTTTAT TCGACAACTC GCAAGGACAAAAAGACCAAA 3101 CTACTGCTAC GTTCCATTTA AAAAATGGTT CTCGTATTGA GGCCAACCAA3151 TGGCATGTCC GAGACTACCA CATCGAGACT TATAAAGAAC GCATCATCGA 3201AAACCGGCCG GCACACATTA CTGTGGGCGG TGATTTGACT GCCTCAGGTC 3251 AAAATTGGCTGAACAAAGAC AGCCGGATTG TAGTAGGCGG GCGTATTATC 3301 ACTGATGATT TAAACCAGAAAGAAATTACC AATCAAAGTA CAACAGGCAA 3351 AGGTCGCACA GATGCTGTCG GCACACAGTGGGATTCAGTT ACAAAAAAAG 3401 GATGGTACAG CGGTAGAAAA AGACAACGCC GTACTGAAAGAAACCATACT 3451 CCTTACCATG ATACCCAACT ATTTACCCAC GACTTCGACA CGCCTGTATC3501 CGTCATCCAA CAGAATGCCG CCTCCCCTTC CTTTCAACCC GCCGCATCTG 3551CAATCAAACT GATTGACGGA GTATCCACGG CAGCCGTCAA TGGTCAGCGC 3601 ATCCATACCGGTAATGTGGT CTCGTTAAAT AACGCTACTG TTACTCTGCC 3651 TAACAGCAGC CTCTATACCACCCATCCTGA CAATAAAGGC TGGTTGGTTG 3701 AAACCGATCC TCAATTTGCA GACTACCGCCGCTGGTTGGG CAGCGACTAC 3751 ATGTTGCAAC AACTGCAATT GGACACCAAT CATCTACACAAACGGCTTGG 3801 CGACGGCTAC TACGAACAAA AACTTGTTAA TGAACAAATC CATCAGTTAA3851 CAGGCTACCG CCGACTCGAC GGCTACAGGA GTGATGAAGA ACAATTCAAA 3901GCTCTGATGG ACAACGGCCT TACTGCTGCC AAAACATTCG GTCTCACCCC 3951 AGGTATCGCCTTGAGTGCAG AGCAAGTTGC CCGCTTAACT TCAGATATCG 4001 TTTGGATGGA AAATCAAACCGTCACCCTGT CTGACGGTTC GACTCAAACC 4051 GTACTGGTTC CTAAAGTCTA TGCCCTGGCGCGCAAAGGTG ATCTCAATAC 4101 CTCCGGTGGC CTGATTAGTG CCGAACAAGT CTTACTTAAACTGCAAAACG 4151 GCAACCTGAC TAACAGCGGT ACCATTGCGG GGCGACAGGC CGTACTCATC4201 CAGGCACGGA ATATTAACAG CAACGGTAAC ATTCAAGCCG ACCAAATCGG 4251CTTAAAAGCT GAAAAAAGTA TCAATATCGA CGGCGGGCAG GTACAAGCAG 4301 GCAGACTGCTGACTGCCCAA GCGCAAAATA TCAACCTTAA CGGTACAACC 4351 CAAACTTCCG GTAATGAACGTAACGGCAAT ACCGCCATCG ATCGTATGGC 4401 CGGCATTAAC GTGGTCGGAA GCCATACTGAACAAGTAGAT AACAGAACTT 4451 CAGACGGCAT CCTATCCCTG CATGCCAGCA ACGATATCAACCTCAATGCG 4501 GCCACCGTCT CTAACCAAGT TAAAGACGGC ACTACCCAAA TTACCGCCGG4551 CAATAATCTC AACCTCGGCA CCATCCGTAC CGAACATCGC GAAGCCTATG 4601GTACATTAGA TGACGAGAAC CATCGCCATG TCCGCCAAAG TACCGAAGTC 4651 GGCAGCAGTATCCGCACGCA AAACGGCGCA CTGCTTAGAG CCGGTAACGA 4701 CTTAAAAATC CGCCAAGGCGAACTGGAGGC CGAAGAAGGC AAAACCGTCC 4751 TTGCCGCAGG ACGTGATGTC ACTATCAGCGAAGGACGCCA AATAACCGAA 4801 CTGGATACCT CGGTAAGCGG AAAAAGCAAA GGCATCCTTTCCAGTACCAA 4851 AACACACGAC CGCTACCGCT TCAGTCATGA TGAAGCAGTC GGCAGCAACA4901 TCGGCGGCGG CAAAATGATT GTTGCAGCCG GGCAGGATAT CAATGTACGC 4951GGCAGCAACC TTATTTCTGA TAAGGGCATT GTTTTAAAAG CAGGACACGA 5001 CATCGATATTTCTACTGCCC ATAATCGCTA TACCGGCAAT GAATACCACG 5051 AGAGCAAAAA ATCAGGCGTCATGGGTACTG GCGGATTGGG CTTTACTATC 5101 GGTAACCGGA AAACTACCGA TGACACTGATCGTACCAATA TTGTCCATAC 5151 AGGCAGCATT ATAGGCAGCC TGAATGGAGA CACCGTTACAGTTGCAGGAA 5201 ACCGCTACCG ACAAACCGGC AGTACCGTCT CCAGCCCCGA GGGGCGCAAT5251 ACCGTCACAG CCAAAAGCAT AGATGTAGAG TTCGCAAACA ACCGGTATGC 5301CACTGACTAC GCCCATACCC AGGAACAAAA AGGCCTTACC GTCGCCCTCA 5351 ATGTCCCGGTTGTCCAAGCT GCACAAAACT TCATACAAGC AGCCCAAAAT 5401 GTGGGCAAAA GTAAAAATAAACGCGTTAAT GCCATGGCTG CAGCCAATGC 5451 TGCATGGCAG AGTTATCAAG CAAAACAACAAATGCAACAA TTTGCTCCAA 5501 GCAGCAGTGC GGGACAAGGT CAAAACAACA ATCAAAGCCCCAGTATCAGT 5551 GTGTCCATTA CCTACGGCGA ACAGAAAAGT CGTAACGAGC AAAAAAGACA5601 TTACACCGAA GCGGCAGCAA GTCAAATTAT CGGCAAAGGG CAAACCACAC 5651TTGCGGCAAC AGGAAGTGGG GAGCAGTCCA ATATCAATAT TACAGGTTCC 5701 GATGTCATCGGCCATGCAGG TACTGCCCTC ATTGCCGACA ACCATATCAG 5751 ACTCCAATCT GCCAAACAGGACGGCAGCGA GCAAAGCAAA AACAAAAGCA 5801 GTGGTTGGAA TGCAGGCGTA GCCGTCAAAATAGGCAACGG CATCAGGTTT 5851 GGAATTACCG CCGGAGGAAA TATCGGTAAA GGTAAAGAGCAAGGGGGAAG 5901 TACTACCCAC CGCCACACCC ATGTCGGCAG CACAACCGGC AAAACTACCA5951 TCCGAAGCGG CGGGGATACC ACCCTCAAAG GTGTGCAGCT CATCGGCAAA 6001GGCATACAGG CAGATACGCG CAACCTGCAT ATAGAAAGTG TTCAAGATAC 6051 TGAAACCTATCAGAGCAAAC AGCAAAACGG CAATGTCCAA GTTACTGTCG 6101 GTTACGGATT CAGTGCAAGCGGCAGTTACC GCCAAAGCAA AGTCAAAGCA 6151 GACCATGCCT CCGTAACCGG GCAAAGCGGTATTTATGCCG GAGAAGACGG 6201 CTATCAAATC AAAGTCAGAG ACAACACAGA CCTCAAGGGCGGTATCATCA 6251 CGTCTAGCCA AAGCGCAGAA GATAAGGGCA AAAACCTTTT TCAGACGGCC6301 ACCCTTACTG CCAGCGACAT TCAAAACCAC AGCCGCTACG AAGGCAGAAG 6351CTTCGGCATA GGCGGCAGTT TCGACCTGAA CGGCGGCTGG GACGGCACGG 6401 TTACCGACAAACAAGGCAGG CCTACCGACA GGATAAGCCC GGCAGCCGGC 6451 TACGGCAGCG ACGGAGACAGCAAAAACAGC ACCACCCGCA GCGGCGTCAA 6501 CACCCACAAC ATACACATCA CCGACGAAGCGGGACAACTT GCCCGAACAG 6551 GCAGGACTGC AAAAGAAACC GAAGCGCGTA TCTACACCGGCATCGACACC 6601 GAAACTGCGG ATCAACACTC AGGCCATCTG AAAAACAGCT TCGACAAAGA6651 CGCGGTCGCC AAAGAGATCA ACCTGCAAAG GGAAGTAACG AAGGAGTTCG 6701GCAGAAACGC CGCCCAAGCC GTAGCGGCCG TTGCCGACAA ACTCGGCAAT 6751 ACCCAAAGTTACGAACGGTA TCAGGAAGCC CGAACCCTGC TGGAGGCCGA 6801 ACTGCAAAAC ACGGACAGCGAAGCCGAAAA AGCCGCCTTC CGCGCATCCC 6851 TCGGCCAAGT AAACGCCTAT CTTGCCGAAAACCAAAGCCG CTACGACACC 6901 TGGAAAGAAG GCGGCATAGG CAGGAGCATA CTGCACGGGGCGGCAGGCGG 6951 ACTGACGACC GGCAGCCTCG GCGGCATACT GGCCGGCGGC GGCACTTCCC7001 TTGCCGCACC GTATTTGGAC AAAGCGGCGG AAAACCTCGG TCCGGCGGGC 7051AAAGCGGCGG TCAACGCACT GGGCGGTGCG GCCATCGGCT ATGCAACTGG 7101 TGGTAGTGGTGGTGCTGTGG TGGGTGCGAA TGTAGATTGG AACAATAGGC 7151 AGCTGCATCC GAAAGAAATGGCGTTGGCCG ACAAATATGC CGAAGCCCTC 7201 AAGCGCGAAG TTGAAAAACG CGAAGGCAGAAAAATCAGCA GCCAAGAAGC 7251 GGCAATGAGA ATCCGCAGGC AGATACTGCG TTGGGTGGACAAAGGTTCCC 7301 AAGACGGCTA TACCGACCAA AGCGTCATAT CCCTTATCGG AATGAAAGGC7351 GAAGACAAAG CCTTGGGTTA TACTTGGGAC TACCGCGACT ACGGCGCAAG 7401AAATCCGCAA ACCTACAACG ATCCGAAGCT GTTTGAGGAA TACCGCCGAC 7451 AGGACAAACCCGAATACCGC AACCTGACCT GGCTGCACAG CGGGACGAAA 7501 GACACCAAAA TCAGGCAGGGAGAGCGGAAA AACGAAGAGT TTGCACTGAA 7551 CGTTGCCGAA GGACTGACGA GCCTTGTCAACCCCAATCCG AGGATAAAAG 7601 TCCCGATTCT TGCAGGCATC CGCAACCTGA AAAACATCAAGCCGACAGTT 7651 ACCGGCAGCG ATCCCTTATT GGCGGGTGCG GGGAATATCC GTATCCCTGC7701 AAACGGCAAT GTTGCGAAGG GGGACAGGAT TCCGGATACG GCATTGGCTA 7751GCAAGGGAAT CAAACATAAA GATCGTAAAG ATCAACTGGA GAAAAAATAAThis corresponds to the amino acid sequence <SEQ ID 1670. ORF 564>:

m564.pep 1 MNRTLYKVVF NKHRNCMIAV AENAKREGKN TADTQAVGIL PNDIAGFAGF 51IHSISVISFS LSLLLGSALI LTSSSATAQG IVADKSAPAQ QQPTILQTGN 101 GIPQVNIQTPTSAGVSVNQY AQFDVGNRGA ILNNSRSNTQ TQLGGWIQGN 151 PWLARGEARV VVNQINSSHSSQLNGYIEVG GRRAEVVIAN PAGIAVNGGG 201 FINASRATLT TAQPQYQAGD LSGFKIRQGNVVIAGHGLDA RDTDYTRILS 251 YHSKIDAPVW GQDVRVVAGQ NDVAATGDAH SPILNNAAANTSNNTANNGT 301 HIPLFAIDTG KLGGMYANKI TLISTVEQAG IRNQGQWFAS AGNVAVNAEG351 KLVNTGMIAA TGENHAVSLH ARNVHNSGTV ASQDDANIHS QTLDNSGTVL 401SSGRLTVRNL GRLKNQNNGT IQAARLDMST GGLDNTGNIT QTGSQALDLV 451 SAGKFDNSGKIGVSDVPQTG LNPNPSVIPQ IPSTATGSGS STVSVSKPGS 501 NNPVSPTAPA KNYAVGRIQTTGAFDNAGSI NAGGQIDIAA QNGLGNSGSL 551 NAAKLRVSGD SFNNTVKGKL QAHDLAVNTQTAKNSGHLLT QTGKIDNREL 601 HNAGEIAANN LTLIHSGRLS NDKKGNIRAA HLQLDTAGLHNAGNILADSG 651 TVTTKNNLRN TGKVSVARLN TEGQTLDNTR GRIEAETVNI QSQQLTNQSG701 HITATEQLTI NSRNVDNQNG KLLSANQAQL AVSDGLYNQH GEIATNRQLS 751IHDKNQNTLA LNNADGTIQS AGNVSLQAKS LANNGTLTAG NKLDIALTDD 801 FVVERDLTAGKQLNLSIKGR LKNTHTLQAG HTLKLNAGNI DNQVTGKIIG 851 GEQTDITSEQ HVDNRGLINSDGLTHIGAGQ TLTNTGTGKI YGNHIALDAQ 901 ILLNREETTE GSTKAGAIAA RKRLDIGAKEIHNQEGALLS SEGIFAVGNR 951 LDEQHHAAGM ADTFVNGSAG LEVQGDALMS VRNMQNINNHFKTETYLAKA 1001 EKQVRDYTVL GQNTYYQAGK DGLFDNSQGQ KDQTTATFHL KNGSRIEANQ1051 WHVRDYHIET YKERIIENRP AHITVGGDLT ASGQNWLNKD SRIVVGGRII 1101TDDLNQKEIT NQSTTGKGRT DAVGTQWDSV TKKGWYSGRK RQRRTERNHT 1151 PYHDTQLFTHDFDTPVSVIQ QNAASPSFQP AASAIKLIDG VSTAAVNGQR 1201 IHTGNVVSLN NATVTLPNSSLYTTHPDNKG WLVETDPQFA DYRRWLGSDY 1251 MLQQLQLDTN HLHKRLGDGY YEQKLVNEQIHQLTGYRRLD GYRSDEEQFK 1301 ALMDNGLTAA KTFGLTPGIA LSAEQVARLT SDIVWMENQTVTLSDGSTQT 1351 VLVPKVYALA RKGDLNTSGG LISAEQVLLK LQNGNLTNSG TIAGRQAVLI1401 QARNINSNGN IQADQIGLKA EKSINIDGGQ VQAGRLLTAQ AQNINLNGTT 1451QTSGNERNGN TAIDRMAGIN VVGSHTEQVD NRTSDGILSL HASNDINLNA 1501 ATVSNQVKDGTTQITAGNNL NLGTIRTEHR EAYGTLDDEN HRHVRQSTEV 1551 GSSIRTQNGA LLRAGNDLKIRQGELEAEEG KTVLAAGRDV TISEGRQITE 1601 LDTSVSGKSK GILSSTKTHD RYRFSHDEAVGSNIGGGKMI VAAGQDINVR 1651 GSNLISDKGI VLKAGHDIDI STAHNRYTGN EYHESKKSGVMGTGGLGFTI 1701 GNRKTTDDTD RTNIVHTGSI IGSLNGDTVT VAGNRYRQTG STVSSPEGRN1751 TVTAKSIDVE FANNRYATDY AHTQEQKGLT VALNVPVVQA AQNFIQAAQN 1801VGKSKNKRVN AMAAANAAWQ SYQATQQMQQ FAPSSSAGQG QNNNQSPSIS 1851 VSITYGEQKSRNEQKRHYTE AAASQIIGKG QTTLAATGSG EQSNINITGS 1901 DVIGHAGTAL IADNHIRLQSAKQDGSEQSK NKSSGWNAGV AVKIGNGIRF 1951 GITAGGNIGK GKEQGGSTTH RHTHVGSTTGKTTIRSGGDT TLKGVQLIGK 2001 GIQADTRNLH IESVQDTETY QSKQQNGNVQ VTVGYGFSASGSYRQSKVKA 2051 DHASVTGQSG IYAGEDGYQI KVRDNTDLKG GIITSSQSAE DKGKNLFQTA2101 TLTASDIQNH SRYEGRSFGI GGSFDLNGGW DGTVTDKQGR PTDRISPAAG 2151YGSDGDSKNS TTRSGVNTHN IHITDEAGQL ARTGRTAKET EARIYTGIDT 2201 ETADQHSGHLKNSFDKDAVA KEINLQREVT KEFGRNAAQA VAAVADKLGN 2251 TQSYERYQEA RTLLEAELQNTDSEAEKAAF RASLGQVNAY LAENQSRYDT 2301 WKEGGIGRSI LHGAAGGLTT GSLGGILAGGGTSLAAPYLD KAAENLGPAG 2351 KAAVNALGGA AIGYATGGSG GAVVGANVDW NNRQLHPKEMALADKYAEAL 2401 KREVEKREGR KISSQEAAMR IRRQILRWVD KGSQDGYTDQ SVISLIGMKG2451 EDKALGYTWD YRDYGARNPQ TYNDPKLFEE YRRQDKPEYR NLTWLHSGTK 2501DTKIRQGERK NEEFALNVAE GLTSLVNPNP RIKVPILAGI RNLKNIKPTV 2551 TGSDPLLAGAGNIRIPANGN VAKGDRIPDT ALASKGIKHK DRKDQLEKK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m564/fha ID FHAB_BORPE STANDARD; PRT; 3591 AA. AC P12255; DT 01-OCT-1989(REL. 12, CREATED) DT 01-FEB-1996 (REL. 33, LAST SEQUENCE UPDATE) DT01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE) DE FILAMENTOUSHEMAGGLUTININ.... SCORES Init1: 190 Initn: 524 Opt: 594 Smith-Watermanscore: 866; 21.7% identity in 2427 aa overlap          10        20        30        40        50        60 m564.pep  MNRTLYKVVFNKHRNCMIAVAENAKREGKNTADTQAVGILPNDIAGFAGFIHSISVISFS  || :||::||:: |: :: |:|:    | ||   :: |   :  :|  :   |::  :::fhab_borpe  MNTNLYRLVFSHVRGMLVPVSEHCTV-G-NTFCGRTRG---QARSGARATSLSVAPNALA          10        20          30           40        50           70        80        90       100       110      119 m564.pep  LSLLLG-SALILTSSSATAQGIVADKSAPAQQQPTILQTGNGIPQVNIQTPTSAGVSVNQ    :|:|:::| |::    |||:|     | | |  :|| || :| |||  |:|:||| |: fhab_borpe  WALMLACTGLPLVTH---AQGLV-----P-QGQTQVLQGGNKVPVVNIADPNSGGVSHNK     60        70                 80        90       100120       130       140       150       160       170      179 m564.pep  YAQFDVGNRGAILNNSRSNTQTQLGGWIQGNPWLARGEARVVVNQINSSHSSQLNGYIEV   :||:|:| |:::||: ::  :::|| :  || |:| :| ::: :::::  |:| | :|| fhab_borpe  FQQFNVANPGVVFNNGLTDGVSRIGGALTKNPNLTR-QASAILAEVTDTSPSRLAGTLEV   110       120       130       140        150       160180       190       200       210       220       230      239 m564.pep  GGRRAEVVIANPAGIAVNGGGFINASRATLTTAQPQYQAGDLSGFKIRQGNVVIAGHGLD    |:|:::|||| ||:||| : :|||  ||||::|: ::| : |: ::||:|:|   |:: fhab_borpe  YGKGADLIIANPNGISVNGLSTLNASNLTLTTGRPSVNGGRI-GLDVQQGTVTIERGGVN    170       180       190       200        210       220240       250          260          270       280       290 m564.pep  ARDTDYTRILSYHSKIDAPV---WGQ---DVRVVAGQNDVAATGDAHSPILNNAAANTSN  |    |  :::   |::: |    |:   |: |||| |    :    :||    ||:: :fhab_borpe  ATGLGYFDVVARLVKLQGAVSSKQGKPLADIAVVAGANRYDHATRRATPI----AAGARG     230       240       250       260       270           280      300       310       320       330       340       350 m564.pep  NTANNGTHIPLFAIDTGKLGGMYANKITLISTVEQAGIRNQGQWFASAGNVAVNAEGKLV   :|:       :|||    |:||:::|||:|:    |:|: |: ::| : ::|:::|:::fhab_borpe  AAAGA------YAIDGTAAGAMYGKHITLVSSDSGLGVRQLGS-LSSPSAITVSSQGEIA               290       300       310        320       330      360       370       380       390       400       410 m564.pep  NTGMIAATGENHAVSLHARNVHNSGTVASQDDANIHSQTLDNSGTVLSSGRLTVRNLGRL     :  || :   :||:: :| ::| :||   |     :: ::|:|  :   :: ::| |fhab_borpe  ---LGDATVQRGPLSLKGAGVVSAGKLASGGGAV----NVAGGGAVKIA---SASSVGNL         340       350       360           370          380      420       430       440       450       460       470 m564.pep  KNQNNGTIQAARLDMSTGGLDNTGNITQTGSQALDLVSAGKFDNSGKIGVSDVPQTGLNP    |::| :||: |: :       |::  :| ||::| :|:: :  :  : : :    |: fhab_borpe  AVQGGGKVQATLLNAG-------GTLLVSGRQAVQLGAASSRQALSVNAGGALKADKLSA      390              400       410       420       430       480       490       500       510       520        530 m564.pep  NPSV-IPQIPSTATGSGSSTVSVSKPGSNNPVSPTAPAKNYAVGRIQTTGAFD-NAGSIN  :  | :    ::| ||:||::   : |:         :|  |:||::: |    : ||: fhab_borpe  TRRVDVDGKQAVALGSASSNALSVRAGGA-----LKAGKLSATGRLDVDGKQAVTLGSVA   440       450       460            470       480       490        540       550      55     560             570      579 m564.pep  AGGQIDIAAQNGLGNSGSLNAAKLRVSG------DSFNNT------VKGKLQAHDLAVNT   :| ::::| ::|  :  :::|:|:| |      |: :::      : | | |::|  : fhab_borpe  SDGALSVSAGGNLRANELVSSAQLEVRGQREVALDDASSARGMTVVAAGALAARNLQSKG        500       510       520       530       540       550580       590       600         610       620       630 m564.pep  QTAKNSGHLLTQTGKIDNRELH--NAGEIAANNLTLIHSGRLSNDKKGNIRAAHLQLDTA     :::|: :: ::  :: ||:  : |::  ::|:  ::: :|:: : ||  |: : |: fhab_borpe  AIGVQGGEAVSVANANSDAELRVRGRGQVDLHDLSAARGADISGEGRVNIGRARSDSDVK        560       570       580       590       600       610  640       650       660       670       680       690 m564.pep  GLHNAGNILADSGTVTTKNNLRNTGKVSVARLNTEGQTLDNTRGRIEAETVNIQSQQLTN   :   | :  || |:    :::  |:||:  : ::| :  :  |     :||: : | fhab_borpe  -VSAHGALSIDSMTALGAIGVQAGGSVSAKDMRSRGAVTVSGGG-----AVNLGDVQ---         620       630       640       650            660  700       710       720       730       740       750 m564.pep  QSGHITATEQLTINSRNVDNQNGKLLSANQAQLAVSDGLYNQHGEIATNRQLSIHDKNQN   ::|::||   ::: |:|         |  |:||:: |   | | : :   :::: :: fhab_borpe  SDGQVRATSAGAMTVRDV---------AAAADLALQAGDALQAGFLKSAGAMTVNGRDAV       670       680                690       700       710  760       770       780       790       800       810 m564.pep  TLALNNADGTIQSAGNVSLQAKSLANNGTLTAGNKLDIALTDDFVVERDLTAGKQL-NLS   |     ||: :::|:: ::: : |  |:|:| ::| :: :   :|  :|   |:| |:|fhab_borpe  RL-----DGA-HAGGQLRVSSDGQAALGSLAAKGELTVSAARAATVA-EL---KSLDNIS            720       730       740       750           760   820        830        840       850       860       870 m564.pep  IKGRLK-NTHTLQAGHTLKLNA-GNIDNQVTGKIIGGEQTDITSEQHVDNRGLINSDGLT   : |  :::::::::  : ::| | :|   :||:  : :: |  |    : | :::|:| fhab_borpe  VTGGERVSVQSVNSASRVAISAHGALD---VGKV--SAKSGIGLE----GWGAVGADSL-      770       780       790            800           810     880       890       900       910       920        930 m564.pep  HIGAGQTLTNTGTGKIYGNHIALDAQILLNREETTEGSTKAGAIAARKRLDI-GAKEIHN    |:  ::: :|   :  ::    |:| |:    :||::  ||: |   :|: |:: : fhab_borpe  --GSDGAISVSGRDAVRVDQARSLADISLG----AEGGATLGAVEAAGSIDVRGGSTV--        820       830       840           850       860      940       950       960       970       980       990 m564.pep  QEGALLSSEGIFAVGNRLDEQHHAAGMADTFVNGSAGLEVQGDALMSVRNMQNINNHFKT    ::| ::: : : |:  |  : :|: :   :: |:| :::  |::: |:   :::   :fhab_borpe  AANSLHANRDVRVSGK--DAVRVTAATSGGGLHVSSGRQLDLGAVQA-RGALALDGGAGV    870       880         890       900       910        920     1000        1010      1020      1030      1040      1050 m564.pep  ETYLAKAEK--QVRDYTVLGQNTYYQAGKDGLFDNSQGQKDQTTATFHLKNGSRIEANQ-      |||    :|:    |  :|   :|   :    :|  |  :| :    |: ::|:: fhab_borpe  ALQSAKASGTLHVQGGEHLDLGTLAAVGAVDV----NGTGDVRVAKLVSDAGADLQAGRS       930       940       950           960       970          1060      1070      1080      1090      1100 m564.pep  --WHVRDYHIETYKERIIENRPAHITVGGDLTASGQNWLNKDSRIVVGGRIITDDLNQKE       :|   :   :   : : : :   | | |:: : |:  :  |:|:  ::   :| fhab_borpe  MTLGIVDTTGDLQARAQQKLELGSVKSDGGLQAAAGGALSLAAAEVAGALELS---GQGV 980       990      1000      1010      1020      10301110      1120      1130        1140      1150      1160 m564.pep  ITNQSTTGKGRTDAVGTQWDSVTKKGWY--SGRKRQRRTERNHTPYHDTQLFTHDFDTPV   :::::::::| |::|:   :: | |    :: :| ||: |            :|| || fhab_borpe  TVDRASASRARIDSTGSVGIGALKAGAVEAASPRRARRALR------------QDFFTPG   1040      1050      1060      1070                  1080     1170      1180      1190      1200      1210      1220 m564.pep  SVI---QQNAASPSFQPAASAIKLIDGVSTAAVNGQRIHTGNVVSLNNATVTLPNSSLYT  ||:   | |::    :|  :::   | :  |  :|  :   | :  :|:|||:  :| fhab_borpe  SVVVRAQGNVTVGRGDPHQGVLAQGDIIMDA--KGGTLLLRNDALTENGTVTISADSAVL     1090      1100      1110        1120      1130      1140     1230       1240      1250      1260      1270      1280 m564.pep  THPDNKGWLVETD-PQFADYRRWLGSDYMLQQLQLDTNHLHKRLGDGYYEQKLVNEQIHQ    |   ::: ::     :|  :   |  : ::| |  |   : ::|:  :: : ::|| fhab_borpe  EHSTIESKISQSVLAAKGDKGKPAVSVKVAKKLFL--NGTLRAVNDN--NETMSGRQIDV       1150      1160      1170        1180        1190      1290      1300      1310       1320      1330      1340 m564.pep  LTGYRRLDGYRSDEEQFKALMDNGLTAAKTFGLTPG-IALSAEQVARLTSDIVWMENQTV   :|  ::    :|    :|  |:::::  ::    | |:: | :::  :: |   :|: fhab_borpe  VDGRPQI----TDAVTGEARKDESVVSDAALVADGGPIVVEAGELVSHAGGIGNGRNK-- 1200          1210      1220      1230      1240      1250       1350      1360      1370      1380      1390      1400 m564.pep  TLSDGSTQTVLVPKVYALARKGDLNTSGGLISAEQVLLKLQNGNLTNSGTIAGRQAVLIQ      :|::|| :         |:| ::| : :::| :|:: :| |||   :::  :  |: fhab_borpe  --ENGASVTVRTT--------GNLVNKGYISAGKQGVLEV-GGALTNEFLVGSDGTQRIE         1260              1270      1280       1290      1300       1410             1420      1430      1440          1450 m564.pep  ARNINSNGNIQ-------ADQIGLKAEKSINIDGGQVQAGRLLTAQ----AQNINLNGTT   |: |::|::|       |  : :|| ::|  || ::  |::  |     : ::: :: : fhab_borpe  AQRIENRGTFQSQAPAGTAGALVVKAAEAIVHDGVMATKGEMQIAGKGGGSPTVTAGAKA        1310      1320      1330      1340      1350      1360        1460       1470       1480       1490      1500 m564.pep  QTSGNERNGNTAI-DRMAGINVV-GSHTEQVDNRTSD-GILSLHASNDINLNAATVSNQV    ||:|:: ::|  |  :::::  |:    | :| :: | :|::::  :: :| ::: || fhab_borpe  TTSANKLSVDVASWDNAGSLDIKKGGAQVTVAGRYAEHGEVSIQGDYTVSADAIALAAQV        1370      1380      1390      1400      1410      1420   1510      1520          1530      1540               1550 m564.pep  --KDGTTQITAGNNLNLGT-IRTE---HREAYGTLDDENHRHVRQST---------EVGS     :|::::|: ::  ::: ||     : :| | ::: :: :||:::         |:|: fhab_borpe  TQRGGAANLTSRHDTRFSNKIRLMGPLQVNAGGPVSNTGNLKVREGVTVTAASFDNETGA        1430      1440      1450      1460      1470      1480      1560      1570      1580      1590        1600 m564.pep  SIRTQNGALLRAGNDLKIRQGELEAEEGKTVLAAGRDV--TISEGRQITELDTS---VSG    ::::::|  :|   :   |:::::|: |::||: :   |:: |::||  : :     | fhab_borpe  EVMAKSATLTTSGAARN--AGKMQVKEAATIVAASVSNPGTFTAGKDITVISRGGFDNEG        1490        1500      1510      1520      1530    1610      1620         1630       1640      1650      1660 m564.pep  K---SKGILSSTKTHDRYRF---SHDEAV-GSNIGGGKMIVAAGQDINVRGSNLISDKGI  |   :| |: :|:  :  |    :|| :| :|: : ::  : ||:|::|::: :  |:: fhab_borpe  KMESNKDIVIKTEQFSNGRVLDAKHDLTVTASGQADNRGSLKAGHDFTVQAQRI--DNSG1540      1550      1560      1570      1580      1590        1670     16    1680      1690      1700      1710 m564.pep  VLKAGHDIDISTAHNRYTG-----NEYHESKKSGVMGTGGLGFTIGNRKTTDDTDRTNIV   ::||||  ::: | | ||     :: |  ::: : :|| :     |  : | :| || fhab_borpe  TMAAGHDATLKAPHLRNTGQVVAGHDIHIINSAKLENTGRV--DARNDIALDVADFTN--  1600      1610      1620      1630        1640      1650   1720      1730     1    1740      1750      1760      1770 m564.pep  HTGSIIGSLNGDTVTVAGNRYRQT----GSTVSSPEGRNTVTAKSIDVEFANNRYATDYA    |||::  :: |:|:| :  |:        :   ||   | |||: :|: ::  ::  | fhab_borpe  -TGSLYAEHDA-TLTLAQGTQRDLVVDQDHILPVAEGTLRVKAKSLTTEIETGNPGSLIA       1660       1670      1680      1690      1700      1710       1780      1790      1800      1810       1820      1830 m564.pep  HTQEQKGLTVALNVPVVQAAQNFIQAAQNVGKSKNKRVNAMAAANAA-WQSYQATQQMQQ  ::||        |:   ||    | :::::  | : : |:   |||  | : : | : |:fhab_borpe  EVQE--------NIDNKQA----IVVGKDLTLS-SAHGNVANEANALLWAAGELTVKAQN                1720          1730       1740      1750        1840      1850      1860      1870      1880      1890 m564.pep  FAPSSSAGQGQNNNQSPSISVSITYGEQKSRNEQKRHYTEAAASQIIGKGQTTLAATGSG   :: ::|    ::|   : :|::     : |  :  |     | :|    ::|   :| fhab_borpe  ITNKRAALIEAGGNARLTAAVALLNKLGRIRAGEDMHLD---APRI----ENTAKLSGEV 1760      1770      1780      1790         1800          1810        1900      1910      1920      1930      1940      1950 m564.pep  EQSNINITGSDVIGHAGTALIADNHIRLQSAKQDGSEQSKNKSSGWNAGVAVKIGNGIRF   :::::::|:   |: :    ::  :|  ::|: |:      :: | :|  :   : |: fhab_borpe  QRKGVQDVGGGEHGRWSGIGYVNYWLRAGNGKKAGT-----IAAPWYGGDLTAEQSLIEV        1820      1830      1840           1850      1860        1960      1970      1980      1990      2000      2010 m564.pep  GITAGGNIGKGKEQGGSTTHRHTHVGSTTGKTTIRSGGDTTLKGVQLIGKGIQADTRNLH  |     | |  |::     |||       :: :|::||   : |        ::|:|:: fhab_borpe  GKDLYLNAGARKDE-----HRHL-----LNEGVIQAGGHGHIGG--------DVDNRSV-   1870           1880           1890              1900        2020      2030      2040      2050           2060 m564.pep  IESVQDTETYQSKQQNGNVQVTVGYGFSASGSYRQSKVKA-----DHASVTGQSGIYAGE  :::|:  | :::    : : :    |:| :    ||  :      |:       |:| fhab_borpe  VRTVSAMEYFKTPLPVSLTALDNRAGLSPATWNFQSTYELLDYLLDQNRYEYIWGLYPTY  1910      1920      1930      1940      1950      1960   2070      2080      2090      2100      2110        2120 m564.pep  DGYQIKVRDNTDLKGGIITSSQSAEDKGKNLFQTATLTASDIQNHS--RYEGRSFGIGGS    :::::  | || |     : :|    |           |:::|:    |||:: :| fhab_borpe  TEWSVNTLKNLDL-GYQAKPAPTAPPMPKA-------PELDLRGHTLESAEGRKI-FGEY  1970       1980      1990             2000      2010     2130           2140      2150      2160      2170 m564.pep  FDLNGGWDGT-----VTDKQGRPTDRISPAAGYGSDGDSKNSTTRSGVNTHNIHITDEAG    |:| :: :     :::  |: | |:    |      :: : : :|::::: :: fhab_borpe  KKLQGEYEKAKMAVQAVEAYGEATRRVHDQLG------QRYGKALGGMDAETKEVDGIIQ 2020      2030      2040            2050      2060      20702180      2190      2200      2210      2220      2230 m564.pep  QLARTGRTAKETEARIYTGIDTETADQHSGHLKNSFDKDAVAKEINLQREVTKEFGRNAA  ::|   ||:   :|   | ||:|| |: : : |:::|  ||  :     :||  :::  :fhab_borpe  EFAADLRTVYAKQADQAT-IDAET-DKVAQRYKSQID--AVRLQADQPGRVT--LAKALS       2080       2090       2100        2110        21202240      2250      2260       2270      2280      2290 m564.pep  QAVAAVADKLGNTQSYERYQEARTLLE-AELQNTDSEAEKAAFRASLGQVNAYL------   |::|    ||::| ::|::: ::  : ||:    :|    |  |:|   |: : fhab_borpe  AALGADWRALGHSQLMQRWKDFKAGKRGAELAFYPKEQTVLAAGAGLTLSNGAIHNGENA   2130      2140      2150      2160      2170      2180       2300      2310      2320      2330      2340      2350 m564.pep  AENQSRYDTWKEGGIGRSILHGAAGGLTTGSLGGILAGGGTSLAAPYLDKAAENLGPAGK  |:|::| :  | |: : : : |:  :| fhab_borpe  AQNRGRPEGLKIGAHSATSVSGSFDALRDVGLEKRLDIDDALAAVLVNPHIFTRIGAAQT   2190      2200      2210      2220      2230      2240The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1671>:

g565.seq 1 atggacagca cattgtctaa aacgtgttgc gtttcgtgca tattgttgag 51cgtaaccacc accattttcg cccgtcccag accggcggct tccaatactt 101 ccctgcgtttcgcatcgccg aacgacaccg gctcgcctgc acttctggct 151 acctgcacgc gtgcgatgtccaagtcgagc gcgaaatacg gaatatcctc 201 tttgggcgaa gacgcgtccg accgtctgcccgcccctgcc gaagccgaca 251 atcagcacat gatcagactt gctcatcgct tccaccaacatgctgtgcag 301 atcgagcgac ttcatgtccc agcttgaThis corresponds to the amino acid sequence <SEQ ID 1672; ORF 565.ng>:

g565.pep 1 MDSTLSKTCC VSCILLSVTT TIFARPRPAA SNTSLRFASP NDTGSPALLA 51TCTRAMSKSS AKYGISSLGE DASDRLPAPA EADNQHMIRL AHRFHQHAVQ 101 IERLHVPA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1673>:

m565.seq 1 ATGGACAGCA CATTGTCTAA AACGTGTTGC GTTTCGTGCA TATTGTTGAG 51CGTAACCACC ACCATTTTCG CCCGTCCCAG ACCGGCGGCT TCCAATACTT 101 CCCTGCGTTTCGCATCGCCG AACGACACCG GTTCGCCCGC ACTTCTGGCA 151 ACCTGCACCC GCGCAATGTCCAAGTCGAGC GCGAAATACG GAATATCCTC 201 TTGGGCAAGG ACGCGTCCGA CCGTCTGCCCGCCCCTGCCG AAGCCGACAA 251 TCAGCACATG GTCGGACTTG CTCATGGTTT CTACCAGCATACTGTGCAGA 301 TCGAGCGACT TCATGTCCCA GCTTGACTTG ACCAAACGCC CGACCAGCGC351 ATCGCTGCCG CCCAAGAGGA AGGGCGCGAT AATCATCGAC AGCAGAACCG 401CCGCCGTCGC CGCCTGTTCC CATTCTGGCG AAACCATATC AAGCTGCCCG 451 GCAATGGCCAGCATCACGAA GCCGAACTCG CCGCCCTGCG CGAGATACAA 501 AGCCGTTTTG AGGCTGTCGCCGACCGAATG TTTCATTTTG AAGGCAATGG 551 CAAACACAAC CAGTGCCTTC AACACCAGCAGCATTGCCAA CAGCATCAAT 601 ACCTGCCGCC AGCCGCCGAT CAATGCCTGAThis corresponds to the amino acid sequence <SEQ ID 1674; ORF 565>:

m565.pep 1 MDSTLSKTCC VSCILLSVTT TIFARPRPAA SNTSLRFASP NDTGSPALLA 51TCTRAMSKSS AKYGISSWAR TRPTVCPPLP KPTISTWSDL LMVSTSILCR 101 SSDFMSQLDLTKRPTSASLP PKRKGAIIID SRTAAVAACS HSGETISSCP 151 AMASITKPNS PPCARYKAVLRLSPTECFIL KAMANTTSAF NTSSIANSIN 201 TCRQPPINA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m565/g565 100.0% identity in 67 aa overlap        10        20        30        40        50        60 m565.pepMDSTLSKTCCVSCILLSVTTTIFARPRPAASNTSLRFASPNDTGSPALLATCTRAMSKSS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g565MDSTLSKTCCVSCILLSVTTTIFARPRPAASNTSLRFASPNDTGSPALLATCTRAMSKSS        10        20        30        40        50        60        70        80        90       100       110       120 m565.pepAKYGISSWARTRPTVCPPLPKPTISTWSDLLMVSTSILCRSSDFMSQLDLTKRPTSASLP |||||||g565 AKYGISSLGEDASDRLPAPAEADNQHMIRLAHRFHQHAVQIERLHVPAXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1675>:

a565.seq 1 ATGGACAGCA CATTGTCTAA AACGTGTTGC GTTTCGTGCA TATTGTTGAG 51CGTAACCACC ACCATTTTCG CCCGTCCCAG ACCGGCGGCT TCCAATACTT 101 CCCTGCGTTTCGCATCGCCG AACGACACCG GTTCGCCCGC ACTTCTGGCA 151 ACCTGCACCC GCGCAATGTCCAAGTCGAGC GCGAAATACG GAATATCCTC 201 TTGGGCAAGG ACGCGTCCGA CCGTCTGCCCGCCCCTGCCG AAGCCGACAA 251 TCAGCACATG GTCGGACTTG CTCATGGTTT CTACCAGCATACTGTGCAGA 301 TCGAGCGACT TCATGTCCCA GCTTGACTTG ACCAAACGCC CGACCAGTGC351 ATCGCTGCCG CCCAAGAGGA AGGGCGCGAT AATCATCGAC AGCAGAACCG 401CCGCCGTCGC CGCCTGTTCC CATTCTAGCG AAACCATATC AAGCTGCCCG 451 GCAATGGCCAGCATCACGAA GCCGAACTCG CCGCCCTGCG CGAGATACAA 501 AGCCGTTTTG AGGCTGTCGCCGACCGAATG TTTCATTTTG AAGGCAATGG 551 CAAACACAAC CAGTGCCTTC AACACCAGCAGCATTGCCAA CAGCATCAAT 601 ACCTGCCGCC AGCCGCCGAT TAATGCCTGAThis corresponds to the amino acid sequence <SEQ ID 1676; ORF 565.a>:

a565.pep 1 MDSTLSKTCC VSCILLSVTT TIFARPRPAA SNTSLRFASP NDTGSPALLA 51TCTRAMSKSS AKYGISSWAR TRPTVCPPLP KPTISTWSDL LMVSTSILCR 101 SSDFMSQLDLTKRPTSASLP PKRKGAIIID SRTAAVAACS HSSETISSCP 151 AMASITKPNS PPCARYKAVLRLSPTECFIL KAMANTTSAF NTSSIANSIN 201 TCRQPPINA* m565/a565 99.5% identityin 209 aa overlap        10        20        30        40        50        60 m565.pepMDSTLSKTCCVSCILLSVTTTIFARPRPAASNTSLRFASPNDTGSPALLATCTRAMSKSS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a565MDSTLSKTCCVSCILLSVTTTIFARPRPAASNTSLRFASPNDTGSPALLATCTRAMSKSS        10        20        30        40        50        60        70        80        90       100       110       120 m565.pepAKYGISSWARTRPTVCPPLPKPTISTWSDLLMVSTSILCRSSDFMSQLDLTKRPTSASLP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a565AKYGISSWARTRPTVCPPLPKPTISTWSDLLMVSTSILCRSSDFMSQLDLTKRPTSASLP        70        80        90       100       110       120       130       140       150       160       170       180 m565.pepPKRKGAIIIDSRTAAVAACSHSGETISSCPAMASITKPNSPPCARYKAVLRLSPTECFIL||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||| a565PKRKGAIIIDSRTAAVAACSHSSETISSCPAMASITKPNSPPCARYKAVLRLSPTECFIL       130       140       150       160       170       180       190       200       210 m565.pep KAMANTTSAFNTSSIANSINTCRQPPINAX|||||||||||||||||||||||||||||| a565 KAMANTTSAFNTSSIANSINTCRQPPINAX       190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1677>:

g566.seq.. 1 atgccgtctg aacaatatct tttcagacgg cattttgtat gggggttaac 51ggttgttcag cccgagtacg tcctgcatat cgtacaaacc cgttttgccg 101 tttacccaaactgcggcgcg gacggcaccg gcggcaaagg tcatgcggct 151 gccggctttg tgggtgatttccacgcgttc gccgtcggtg gcgaagaggg 201 cggtgtggtc gccgactatg tcgcctgcgcggacggtggc aaagccgatg 251 gtggaaggat cgcgcggacc agtgtggcct tcgcggccgtaaacggcgca 301 ttgtttgagg tcgcggccga gcgcgccggc gatgacttcg cccattcgta351 aThis corresponds to the amino acid sequence <SEQ ID 1678; ORF 566.ng>:

g566.pep.. 1 MPSEQYLFRR HFVWGLTVVQ PEYVLHIVQT RFAVYPNCGA DGTGGKGHAA 51AGFVGDFHAF AVGGEEGGVV ADYVACADGG KADGGRIART SVAFAAVNGA 101 LFEVAAERAGDDFAHS*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1679>:

m566.seq.. 1 ATGCCGTCTG AACAATATCT TTTCAGACGG CATTTTGTAT GGGGGTTAAC 51GGTTGTTCAG CCCGAGTACG TCCTGCATAT CGTACAAACC CGTTTTGCCG 101 TTGACCCAAACTGCGGCGCG GACGGCACCG GCGGCAAAGG TCATGCGGCT 151 GCTGGCCTTG TGGGTGATTTCCACGCGCTC GCCGTCGGTG GCGAAGAGGG 201 CGGTGTGGTC GCCGACGATG TCGCCTGCGCGGACGGTGGC AAAGCCGATG 251 GTCGACGGAT CGCGCGGACC GGTGTGGCCT TCGCGGCCGTAAACGGCGCA 301 TTGTTTGAGG TCTCTGCCGA GCGCGCCGGC GATGACTTCG CCCATGCGTA351 AThis corresponds to the amino acid sequence <SEQ ID 1680; ORF 566>:

m566.pep.. 1 MPSEQYLFRR HFVWGLTVVQ PEYVLHIVQT RFAVDPNCGA DGTGGKGHAA 51AGLVGDFHAL AVGGEEGGVV ADDVACADGG KADGRRIART GVAFAAVNGA 101 LFEVSAERAGDDFAHA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m566/g566 93.1% identity in 116 aa overlap        10        20        30        40        50        60 m566.pepMPSEQYLFRRHFVWGLTVVQPEYVLHIVQTRFAVDPNCGADGTGGKGHAAAGLVGDFHAL|||||||||||||||||||||||||||||||||| |||||||||||||||||:||||||: g566MPSEQYLFRRHFVWGLTVVQPEYVLHIVQTRFAVYPNCGADGTGGKGHAAAGFVGDFHAF        10        20        30        40        50        60        70        80        90       100       110 m566.pepAVGGEEGGVVADDVACADGGKADGRRIARTGVAFAAVNGALFEVSAERAGDDFAHAX|||||||||||| ||||||||||| |||||:|||||||||||||:||||||||||:| g566AVGGEEGGVVADYVACADGGKADGGRIARTSVAFAAVNGALFEVAAERAGDDFAHSX        70        80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1681>:

a566.seq 1 ATGCCGTCTG AACAATATCT TTTCAGACGG CATTTTGTAT GGGGGTTAAC 51GGTTGTTCAG CCCGAGTACG TCCTGCATAT CGTACAAACC CGTTTTACCG 101 TTTACCCAAACTGCGGCGCG GACGGCGCCG GCGGCAAAGG TCATGCGGCT 151 GCTTGCCTTG TGGGTGATTTCCACGCGCTC GCCGTCGGTG GCGAAGAGGG 201 CGGTGTGGTC GCCGACGATG TCGCCCGCGCGGACGGTGGC AAAGCCGATG 251 GTGGACGGAT CGCGCGGGCC GGTGTGGCCT TCGCGGCCGTAAACGGCGCA 301 TTGTTTGAGG TCTCTGCCGA GCGCGCCGGC GATGACTTCG CCCATGCGTA351 AThis corresponds to the amino acid sequence <SEQ ID 1682; ORF 566.a>:

a566.pep 1 MPSEQYLFRR HFVWGLTVVQ PEYVLHIVQT RFTVYPNCGA DGAGGKGHAA 51ACLVGDFHAL AVGGEEGGVV ADDVARADGG KADGGRIARA GVAFAAVNGA 101 LFEVSAERAGDDFAHA* m566/a566 94.0% identity in 116 aa overlap        10        20        30        40        50        60 m566.pepMPSEQYLFRRHFVWGLTVVQPEYVLHIVQTRFAVDPNCGADGTGGKGHAAAGLVGDFHAL||||||||||||||||||||||||||||||||:| |||||||:|||||||| |||||||| a566MPSEQYLFRRHFVWGLTVVQPEYVLHIVQTRFTVYPNCGADGAGGKGHAAACLVGDFHAL        10        20        30        40        50        60        70        80        90       100       110 m566.pepAVGGEEGGVVADDVACADGGKADGRRIARTGVAFAAVNGALFEVSAERAGDDFAHAX||||||||||||||| |||||||| ||||:||||||||||||||||||||||||||| a566AVGGEEGGVVADDVARADGGKADGGRIARAGVAFAAVNGALFEVSAERAGDDFAHAX        70        80        90       100       110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1683>:

g567.seq.. 1 atgcgacgac gggcagcggc atcgacaagg cgggtttgca gtccggcgtt 51tatcaggtct tattgggcga tgcggacgtg cagtcggcgg cggtacgcag 101 caaagagggcggatacggcg tgttgggtgc gaacgcgcgc gcttgccggc 151 gcggaaatcg agctggtgcaggaaatcgcc cgggaagtgc gtttgaaaaa 201 cgcgctcaag gcagtggcgg aagattacgactttatcctg atcgactgtc 251 cgccttcgct gacgctgttg acgcttaacg gcttggtggcggcgggcggc 301 gtgattgtgc cgatgttgtg cgaatattac gcgctggaag ggatttccga351 tttgattgcg accgtgcgca aaatccgtca ggcggtcaat cccgatttgg 401acatcacggg catcgtgcgt acgatgtacg acagccgcag caggctggtt 451 gccgaagtcagcgaacagtt gcgcagccat ttcggggatt tgctttttga 501 aaccgccatc ccgcgcaatatccgccttgc ggaagcgccg agccacggta 551 tgccggtgat ggcttacgac gcgcaggcaaagggtgccaa ggcgtatctt 601 gccttggcgg acgaactggc ggcgagggtg tcggggaaat agThis corresponds to the amino acid sequence <SEQ ID 1684; ORF 567.ng>:

g567.pep 1 MRRRAAASTR RVCSPAFIRS YWAMRTCSRR RYAAKRADTA CWVRTRALAG 51AEIELVQEIA REVRLKNALK AVAEDYDFIL IDCPPSLTLL TLNGLVAAGG 101 VIVPMLCEYYALEGISDLIA TVRKIRQAVN PDLDITGIVR TMYDSRSRLV 151 AEVSEQLRSH FGDLLFETAIPRNIRLAEAP SHGMPVMAYD AQAKGAKAYL 201 ALADELAARV SGK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1685>:

m567.seq.. 1 ATGAGTGCGA ACATCCTTGC CATCGCCAAT CAGAAGGGCG GTGTGGGCAA 51AACGACGACG ACGGTAAATT TGGCGGCTTC GCTGGCATCG CGCGGCAAAC 101 GCGTGCTGGTGGTCGATTTG GATCCGCAGG GCAATGCGAC GACGGGCAGC 151 GGCATCGACA AGGCGGGTTTGCAGTCCGGC GTTTATCAGG TCTTATTGGG 201 CGATGCGGAC GTGCAGTCGG CGGCGGTACGCAGCAAAGAG GGCGGATACG 251 CTGTGTTGGG TGCGAACCGC GCGCTGGCCG GCGCGGAAATCGAACTGGTG 301 CAGGAAATCG CCCGGGAAGT GCGTTTGAAA AACGCGCTCA AGGCAGTGGA351 AGAAGATTAC GACTTTATCC TGATCGACTG CCCGCCTTCG CTGACGCTGT 401TGACGCTTAA CGGGCTGGTG GCGGCGGGCG GCGTGATTGT GCCGATGTTG 451 TGCGAATATTACGCGCTGGA AGGGATTTCC GATTTGATTG CGACCGTGCG 501 CAAAATCCGT CAGGCGGTCAATCCCGATTT GGACATCACG GGCATCGTGC 551 GCACGATGTA CGACAGCCGC AGCAGGCTGGTTGCCGAAGT CAGCGAACAG 601 TTGCGCAGCC ATTTCGGGGA TTTGCTTTTT GAAACCGTCATCCCGCGCAA 651 TATCCGCCTT GCGGAAGCGC CGAGCCACGG TATGCCGGTG ATGGCTTACG701 ACGCGCAGGC AAAGGGTACC AAGGCGTATC TTGCCTTGGC GGACGAGCTG 751GCGGCGAGGG TGTCGGGGAA ATAGThis corresponds to the amino acid sequence <SEQ ID 1686; ORF 567>:

m567.pep.. 1 MSANILAIAN QKGGVGKTTT TVNLAASLAS RGKRVLVVDL DPQGNATTGS 51GIDKAGLQSG VYQVLLGDAD VQSAAVRSKE GGYAVLGANR ALAGAEIELV 101 QEIAREVRLKNALKAVEEDY DFILIDCPPS LTLLTLNGLV AAGGVIVPML 151 CEYYALEGIS DLIATVRKIRQAVNPDLDIT GIVRTMYDSR SRLVAEVSEQ 201 LRSHFGDLLF ETVIPRNIRL AEAPSHGMPVMAYDAQAKGT KAYLALADEL 251 AARVSGK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m567/g567 98.2% identity in 168 aa overlap 60        70        80        90       100       110      119 m567.pep  GVYQVLLGDADVQSAAVRSKEGGYAVLGANRALAGAEIELVQEIAREVRLKNALKAVEED                                ||||||||||||||||||||||||||| || g567  AFIRSYWAMRTCSRRRYAAKRADTACWVRTRALAGAEIELVQEIAREVRLKNALKAVAED     20        30        40        50        60        70120       130       140       150       160       170      179 m567.pep  YDFILIDCPPSLTLLTLNGLVAAGGVIVPMLCEYYALEGISDLIATVRKIRQAVNPDLDI  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g567  YDFILIDCPPSLTLLTLNGLVAAGGVIVPMLCEYYALEGISDLIATVRKIRQAVNPDLDI     80        90       100       110       120       130180       190       200       210       220       230      239 m567.pep  TGIVRTMYDSRSRLVAEVSEQLRSHFGDLLFETVIPRNIRLAEAPSHGMPVMAYDAQAKG  |||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||| g567  TGIVRTMYDSRSRLVAEVSEQLRSHFGDLLFETAIPRNIRLAEAPSHGMPVMAYDAQAKG    140       150       160       170       180       190  240       250 m567.pep   TKAYLALADELAARVSGKX   :|||||||||||||||||||g567   AKAYLALADELAARVSGKX   200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1687>:

a567.seq 1 ATGAGTGCGA ACATCCTTGC CATCGCCAAT CAGAAGGGCG GTGTGGGCAA 51AACGACGACG ACGGTAAATT TGGCGGCTTC GCTGGCATCG CGCGGCAAAC 101 GCGTGCTGGTGGTCGATTTG GATCCGCAGG GCAATGCGAC GACGGGCAGC 151 GGCATCGACA AGGCGAGTTTGCAGTCCGGC GTTTATCAGG TCTTATTGGG 201 CGATGCGGAC GTGAAATCGG CGGCGGTACGCAGCAAAGAG GGCGGATACG 251 GCGTGTTGGG TGCGAACCGC GCGCTGGCCG GCGCGGAAATCGAGCTGGTG 301 CAGGAAATCG CCCGGGAAGT GCGTTTGAAA AACGCGCTCA AGGCAGTGGC351 GGAAGATTAC GACTTTATCC TGATCGACTG CCCGCCTTCG CTGACGCTGT 401TGACGCTTAA CGGCTTGGTG GCGGCAGGCG GCGTGATTGT GCCGATGTTG 451 TGCGAATATTACGCGCTGGA AGGGATTTCC GATTTGATTG CGACCGTGCG 501 CAAAATCCGT CAGGCGGTCAATCCCGATTT GGATATCACG GGCATCGTGC 551 GTACGATGTA CGACAGCCGC AGCAGGCTAGTTGCCGAAGT CAGCGAACAG 601 TTGCGCAGCC ATTTCGGGGA TTTGCTGTTT GAAACCGTCATCCCGCGCAA 651 TATCCGCCTT GCGGAAGCGC CGAGCCACGG TATGCCGGTG ATGGCTTATG701 ATGCGCAGGC AAAGGGTGCC AAGGCGTATC TTGCCTTGGC GGACGAGCTG 751ATGGCGAGGG TGTCGGGGAA ATAGThis corresponds to the amino acid sequence <SEQ ID 1688; ORF 567.a>:

a567.pep 1 MSANILAIAN QKGGVGKTTT TVNLAASLAS RGKRVLVVDL DPQGNATTGS 51GIDKASLQSG VYQVLLGDAD VKSAAVRSKE GGYGVLGANR ALAGAEIELV 101 QEIAREVRLKNALKAVAEDY DFILIDCPPS LTLLTLNGLV AAGGVIVPML 151 CEYYALEGIS DLIATVRKIRQAVNPDLDIT GIVRTMYDSR SRLVAEVSEQ 201 LRSHFGDLLF ETVIPRNIRL AEAPSHGMPVMAYDAQAKGA KAYLALADEL 251 MARVSGK* m567/a567 97.7% identity in 257 aaoverlap         10        20        30        40        50        60m567.pep MSANILAIANQKGGVGKTTTTVNLAASLASRGKRVLVVDLDPQGNATTGSGIDKAGLQSG|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||| a567MSANILAIANQKGGVGKTTTTVNLAASLASRGKRVLVVDLDPQGNATTGSGIDKASLQSG        10        20        30        40        50        60        70        80        90       100       110       120 m567.pepVYQVLLGDADVQSAAVRSKEGGYAVLGANRALAGAEIELVQEIAREVRLKNALKAVEEDY|||||||||||:|||||||||||:|||||||||||||||||||||||||||||||| ||| a567VYQVLLGDADVKSAAVRSKEGGYGVLGANRALAGAEIELVQEIAREVRLKNALKAVAEDY        70        80        90       100       110       120       130       140       150       160       170       180 m567.pepDFILIDCPPSLTLLTLNGLVAAGGVIVPMLCEYYALEGISDLIATVRKIRQAVNPDLDIT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a567DFILIDCPPSLTLLTLNGLVAAGGVIVPMLCEYYALEGISDLIATVRKIRQAVNPDLDIT       130       140       150       160       170       180       190       200       210       220       230       240 m567.pepGIVRTMYDSRSRLVAEVSEQLRSHFGDLLFETVIPRNIRLAEAPSHGMPVMAYDAQAKGT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: a567GIVRTMYDSRSRLVAEVSEQLRSHFGDLLFETVIPRNIRLAEAPSHGMPVMAYDAQAKGA       190       200       210       220       230       240        250m567.pep KAYLALADELAARVSGKX |||||||||| ||||||| a567 KAYLALADEL MARVSGKX       250The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1689>:

g568.seq 1 atgctcaggg tcagaccggt attatttgcc gtcaaggctt ccgcctcttc 51gataccttgc agaatctgcc gattaaagcg ttcgcggctg cccaatattt 101 tcaggcgcatattgttttcg tgcaggcggc gtacctgttt ttgcaaagcc 151 tgtaaaaaca gccccatcaggaacgaaact tcgtcttcgg ggcgacgcca 201 gttttcggtt gaaaaggcaa acacggtcagatattgcacg cccagtttgg 251 cgcaatgctt caccatattt tccaacgcgt ccaagccgcgtttgtgtccc 301 attatacgcg ggagaaaacg ttttttcgcc caacggccgt tgccgtccat351 aattacggcg atgtgcctcg ggatggcggt gtgttccaaa atggtctgcg 401tgctgctctt catatctgcc tttcgcggtt cggcgttcaa atgccgtctg 451 aacgccgcgccgtgaThis corresponds to the amino acid sequence <SEQ ID 1690; ORF 568.ng>:

g568.pep 1 MLRVRPVLFA VKASASSIPC RICRLKRSRL PNIFRRILFS CRRRTCFCKA 51CKNSPIRNET SSSGRRQFSV EKANTVRYCT PSLAQCFTIF SNASKPRLCP 101 IIRGRKRFFAQRPLPSIITA MCLGMAVCSK MVCVLLFISA FRGSAFKCRL 151 NAAP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1691>:

m568.seq 1 ATGCTCAGGG TCAGGCCGGT ATTGTTTGCC GTCAACGCTT CCGCCTCTTC 51GATGCCTTGC AGAATCTGCC GGTTGAAGCG TTCGCGGCTG CCCAATATCT 101 TCAGGCGCATATTGTTTTCG TGCAGGCGGC GTACCTGTTT TTGCAAAGCC 151 TGTAAAAACA GCCCCATCAGGAACGAAACT TCGTCTTCGG GGCGGCGCCA 201 GTTTTCGGTT GAAAAGGCAA ACACGGTCAGATATTGCACA CCCAGTTTGG 251 CGCAATGCTT CACCATATTT TCCAATGCGT CCAAACCGCGTTTGTGTCCC 301 ATTATGCGCG GGAGGAAACG TTTTTTCGCC CAACGGCCGT TGCCGTCCAT351 AATCACGGCG ATATGCTTGG GAATGGCGGT GTGTTCCAAA ACGGCCTGCG 401TGCTGCTTTT CATGTCTGCC TTTCGCGGTT CGGCATTCAA ATGCCGTCTG 451 AACGCCGAACCGTGCAGGTT AAATTGCCAT CAAATCTTCT TCTTTGGCAG 501 TCAGGAGTTT GTCGGCTTCGGTAATGTATT TGTCGGTCAG TTTTTGAACC 551 GCTTCTTCGC CGCGACGTGC CTCGTCTTCGGAAATTTCTT TGTCTTTGAG 601 GAGTTTTTTG ATGTGGTCGT TGGCATCGCG GCGCACGTTGCGGATAGAGA 651 CGCGGCCTTC TTCCGCTTCG CCGCGTACGA CTTTAATCAG GTCTTTGCGG701 CGTTCCTCGG TCAGCATGGG CATCGGCACG CGGATCAGGT CGCCGACAGC 751TGCCGGGTTC AGTCCCAAGT TTGAThis corresponds to the amino acid sequence <SEQ ID 1692; ORF 568>:

m568.pep.. 1 MLRVRPVLFA VNASASSMPC RICRLKRSRL PNIFRRILFS CRRRTCFCKA 51CKNSPIRNET SSSGRRQFSV EKANTVRYCT PSLAQCFTIF SNASKPRLCP 101 IMRGRKRFFAQRPLPSIITA ICLGMAVCSK TACVLLFMSA FRGSAFKCRL 151 NAEPCRLNCH QIFFFGSQEFVGFGNVFVGQ FLNRFFAATC LVFGNFFVFE 201 EFFDVVVGIA AHVADRDAAF FRFAAYDFNQVFAAFLGQHG HRHADQVADS 251 CRVQSQV*Computer analysis of this amino acid sequence gave the followingresults:

m568/g568 94.8% identity in 154 aa overlap        10        20        30        40        50        60 m568.pepMLRVRPVLFAVNASASSMPCRICRLKRSRLPNIFRRILFSCRRRTCFCKACKNSPIRNET|||||||||||:|||||:|||||||||||||||||||||||||||||||||||||||||| g568MLRVRPVLFAVKASASSIPCRICRLKRSRLPNIFRRILFSCRRRTCFCKACKNSPIRNET        10        20        30        40        50        60        70        80        90       100       110       120 m568.pepSSSGRRQFSVEKANTVRYCTPSLAQCFTIFSNASKPRLCPIMRGRKRFFAQRPLPSIITA|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| g568SSSGRRQFSVEKANTVRYCTPSLAQCFTIFSNASKPRLCPIIRGRKRFFAQRPLPSIITA        70        80        90       100       110       120       130       140       150       160       170       180 m568.pepICLGMAVCSKTACVLLFMSAFRGSAFKCRLNAEPCRLNCHQIFFFGSQEFVGFGNVFVGQ:||||||||| :|||||:|||||||||||||| | g568MCLGMAVCSKMVCVLLFISAFRGSAFKCRLNAAPX        130       140       150       190       200       210       220       230       240 m568.pepFLNRFFAATCLVFGNFFVFEEFFDVVVGIAAHVADRDAAFFRFAAYDFNQVFAAFLGQHGThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1693>:

a568.seq 1 ATGCTCAGGG TCAGGCCGGT ATTGTTTGCC GTCAAGGCTT CCGCCTCTTC 51GATGCCCTTC AGGATTTGAC GGTTGAAGCG TTCGCGGCTG CCCAGTATTT 101 TCAGGCGCATATTGTTTTCG TGCAGGCGGC GTACCTGTTT TTGCAAAGCC 151 TGTAAAAACA GCCCCATCAGGAACGAAACT TCGTCTTCGG GGCGGCGCCA 201 GTTTTCGGTT GAAAAGGCAA ACACGGTCAGATATTGCACA CCCAGTTTGG 251 CGCAATGCTT CACCATATTT TCCAATGCGT CCAAACCGCGTTTGTGTCCC 301 ATTATGCGCG GGAGGAAACG TTTTTTCGCC CAACGGCCGT TGCCGTCCAT351 AATCACGGCG ATATGCTTGG GAATGGCGGT GTGTTCCAAA ACGGCCTGCG 401TGCTGCTTTT CATGTCTGCC TTTCGCGGTT CGGCATTCAA ATGCCGTCTG 451 AACGCCGAACCGTGCAGGTT AAATTGCCAT CAAATCTTCT TCTTTGGCAG 501 TCAGGAGTTT GTCGGCTTCGGTAATGTATT TGTCGGTCAG TTTTTGAACC 551 GCTTCTTCGC CGCGACGTGC CTCGTCTTCGGAAATTTCTT TGTCTTTGAG 601 GAGTTTTTTG ATGTGGTCGT TGGCATCGCG GCGCACGTTGCGGATGGAGA 651 CGCGGCCTTC TTCCGCTTCG CCGCGTACGA CTTTAATCAG GTCTTTGCGG701 CGTTCCTCGG TCAGCATGGG CATCGGCACG CGGATCAGGT CGCCGACAGC 751TGCCGGGTTC AGTCCCAAGT TTGAThis corresponds to the amino acid sequence <SEQ ID 1694; ORF 568.a>:

a568.pep 1 MLRVRPVLFA VKASASSMPF RI*RLKRSRL PSIFRRILFS CRRRTCFCKA 51CKNSPIRNET SSSGRRQFSV EKANTVRYCT PSLAQCFTIF SNASKPRLCP 101 IMRGRKRFFAQRPLPSIITA ICLGMAVCSK TACVLLFMSA FRGSAFKCRL 151 NAEPCRLNCH QIFFFGSQEFVGFGNVFVGQ FLNRFFAATC LVFGNFFVFE 201 EFFDVVVGIA AHVADGDAAF FRFAAYDFNQVFAAFLGQHG HRHADQVADS 251 CRVQSQV* m568/a568 98.1% identity in 257 aaoverlap         10        20        30        40        50        60m568.pep MLRVRPVLFAVNASASSMPCRICRLKRSRLPNIFRRILFSCRRRTCFCKACKNSPIRNET|||||||||||:||||||| || ||||||||:|||||||||||||||||||||||||||| a568MLRVRPVLFAVKASASSMPFRIXRLKRSRLPSIFRRILFSCRRRTCFCKACKNSPIRNET        10        20        30        40        50        60        70        80        90       100       110       120 m568.pepSSSGRRQFSVEKANTVRYCTPSLAQCFTIFSNASKPRLCPIMRGRKRFFAQRPLPSIITA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a568SSSGRRQFSVEKANTVRYCTPSLAQCFTIFSNASKPRLCPIMRGRKRFFAQRPLPSIITA        70        80        90       100       110       120       130       140       150       160       170       180 m568.pepICLGMAVCSKTACVLLFMSAFRGSAFKCRLNAEPCRLNCHQIFFFGSQEFVGFGNVFVGQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a568ICLGMAVCSKTACVLLFMSAFRGSAFKCRLNAEPCRLNCHQIFFFGSQEFVGFGNVFVGQ       130       140       150       160       170       180       190       200       210       220       230       240 m568.pepFLNRFFAATCLVFGNFFVFEEFFDVVVGIAAHVADRDAAFFRFAAYDFNQVFAAFLGQHG||||||||||||||||||||||||||||||||||| |||||||||||||||||||||||| a568FLNRFFAATCLVFGNFFVFEEFFDVVVGIAAHVADGDAAFFRFAAYDFNQVFAAFLGQHG       190       200       210       220       230       240        250m568.pep HRHADQVADSCRVQSQVX |||||||||||||||||| a568 HRHADQVADSCRVQSQVX       250The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1695>:

g569.seq.. 1 atgctgaaac aacgggtaat aaccgctatg tggctgctgc cgctgatgct 51gggcatgctg ttttacgcgc cgcaatggct gtgggctgca ttttgcgggc 101 tgattgccctgaccgccttg tgggagtatg cccgtatggc cggtttgtgc 151 aaaaccgaaa ccaaccattacctcgccgca accttggttt tcggcgtagt 201 tgcctatgcg ggcggctgga tgctgcctaatttggtttgg tatgttgttt 251 tggcattttg gctcgccgtt atgcctttgt ggttgagattcaaatggagg 301 ctcaacggcg gttggcaggt ttatgccgtc ggctggcttt tgctcatgcc351 gttttggttc gcgctcgtat ccctggcgcc cgcatcccga tgaThis corresponds to the amino acid sequence <SEQ ID 1696; ORF 569.ng>:

g569.pep 1 MLKQRVITAM WLLPLMLGML FYAPQWLWAA FCGLIALTAL WEYARMAGLC 51KTETNHYLAA TLVFGVVAYA GGWMLPNLVW YVVLAFWLAV MPLWLRFKWR 101LNGGWQVYAV GWLLLMPFWF ALVSLAPASR *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1697>:

m569.seq.. 1 ATGCTGAAAC AACGGGTAAT AACCGCCATG TGGCTGCTGC CGCTGATGCT 51GGGCATGCTG TTTTACGCGC CGCAATGGTT GTGGGCTGCA TTTTGCGGAC 101 TGATTGCCCTGATTGCCTTG TGGGAATATG CCCGTATGGG CGGTTTGTGC 151 AAAATTAAAA CCAACCATTACCTCGCCGCA ACCTTGGTTT TCGGCGTGGT 201 TGCCTATGCG GGCGGCTGGA TGCTGCCTAATTTGGTTTGG TATGTTGTTT 251 TGGCATTTTG GCTCGCCGTT ATGCCTTTAT GGTTGAGATTCAAATGGAGG 301 CTCAACGGCG GTTGGCAGGT TTATGCCGTC GGCTGGCTTC TGGTCATGCC351 GTTTTGGTTC GCGCTCGTAT CCCTGCGCCC GCATCCCGAT GATGCCCTGC 401CGCTGCTCGC CGTGATGGGT TTGGTGTGGG TTGCCGATAT TTGCGCGTAT 451 TTCAGCGGCAAGGCGTTCGG CAAACACAAA ATCGCGCCGG CAATCAGCCC 501 CGGCAAAAGC TGGGAAGGTGCAATCGGCGG CGCGGTTTGC GTGGCAGTGT 551 ACATGACCGC CGTACGAAGT GCCGGCTGGCTGGCATTCGA TACAGGCTGG 601 TTCGATACCG TGTTAATCGG TTTGGTGCTG ACCGTTGTCAGCGTATGCGG 651 CGACCTTTTG GAAAGCTGGC TCAAGCGCGC GGCAGGCATC AAAGACAGCA701 GCAAGCTGCT GCCCGGACAC GGCGGCGTGT TCGACCGTAC CGACAGCCTG 751ATTGCCGTTA TCAGCGTCTA TGCAGCGATG ATGTCGGTTT TAAATTGAThis corresponds to the amino acid sequence <SEQ ID 1698; ORF 569>:

m569.pep.. 1 MLKQRVITAM WLLPLMLGML FYAPQWLWAA FCGLIALIAL WEYARMGGLC 51KIKTNHYLAA TLVFGVVAYA GGWMLPNLVW YVVLAFWLAV MPLWLRFKWR 101LNGGWQVYAV GWLLVMPFWF ALVSLRPHPD DALPLLAVMG LVWVADICAY 151 FSGKAFGKHKIAPAISPGKS WEGAIGGAVC VAVYMTAVRS AGWLAFDTGW 201 FDTVLIGLVL TVVSVCGDLLESWLKRAAGI KDSSKLLPGH GGVFDRTDSL 251 IAVISVYAAM MSVLN* m569/g569 95.3%identity in 127 aa overlap        10        20        30        40        50        60 m569.pepMLKQRVITAMWLLPLMLGMLFYAPQWLWAAFCGLIALIALWEYARMGGLCKIKTNHYLAA||||||||||||||||||||||||||||||||||||| ||||||||:|||| :||||||| g569MLKQRVITAMWLLPLMLGMLFYAPQWLWAAFCGLIALTALWEYARMAGLCKTETNHYLAA        10        20        30        40        50        60        70        80        90       100       110       120 m569.pepTLVFGVVAYAGGWMLPNLVWYVVLAFWLAVMPLWLRFKWRLNGGWQVYAVGWLLVMPFWF||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| g569TLVFGVVAYAGGWMLPNLVWYVVLAFWLAVMPLWLRFKWRLNGGWQVYAVGWLLLMPFWF        70        80        90       100       110       120       130       140       150       160       170       180 m569.pepALVSLRPHPDDALPLLAVMGLVWVADICAYFSGKAFGKHKIAPAISPGKSWEGAIGGAVC ||||| |g569 ALVSLAPASRX        130The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1699>:

a569.seq 1 ATGCTGAAAC AACGGGTGAT AACCGCCATG TGGCTGCTGC CGCTGATGCT 51GGGCATGCTG TTTTACGCGC CGCAATGGTT GTGGGCTGCA TTTTGCGGAC 101 TGATTGCCCTGATTGCCTTG TGGGAATATG CCCGTATGGG CGGTTTGTGC 151 AAAATTAAAA CCAACCATTACCTCGCCGCA ACCTTGGTTT TCGGCGTGGT 201 TGCCTATGCG GGCGGCTGGA TGCTGCCTAATTTGGTTTGG TATGTTGTTT 251 TGGCATTTTG GCTCGCCGTT ATGCCTTTAT GGTTGAGATTCAAATGGAGG 301 CTCAACGGCG GTTGGCAGGT TTATGCCGTC GGCTGGCTTC TGGTCATGCC351 GTTTTGGTTC GCGCTCGTAT CCCTGCGCCC GCATCCCGAT GATGCCCTGC 401CGCTGCTCGC CGTGATGGGT TTGGTGTGGG TTGCCGATAT TTGCGCGTAT 451 TTCAGCGGCAAGGCGTTCGG CAAACACAAA ATCGCACCGG CAATCAGCCC 501 CGGCAAAAGC TGGGAAGGTGCAATCGGCGG CGCGGTTTGC GTGGCCGTGT 551 ACATGACCGC CGTACGAAGT GCCGGCTGGCTGGCATTCGA TACAGGCTGG 601 TTCGATACCG TGTTAATCGG TTTGGTGTTG ACCGTTGTCAGCGTATGCGG 651 CGACCTTTTG GAAAGCTGGC TCAAGCGCGC GGCAGGCATC AAAGACAGCA701 GCAACCTGCT GCCCGGACAC GGCGGCGTGT TCGACCGCAC CGACAGCCTG 751ATTGCCGTTA TCAGCGTCTA TGCAGCGATG ATGTCGGTTT TAAATTGAThis corresponds to the amino acid sequence <SEQ ID 1700; ORF 569.a>:

a569.pep 1 MLKQRVITAM WLLPLMLGML FYAPQWLWAA FCGLIALIAL WEYARMGGLC 51KIKTNHYLAA TLVFGVVAYA GGWMLPNLVW YVVLAFWLAV MPLWLRFKWR 101LNGGWQVYAV GWLLVMPFWF ALVSLRPHPD DALPLLAVMG LVWVADICAY 151 FSGKAFGKHKIAPAISPGKS WEGAIGGAVC VAVYMTAVRS AGWLAFDTGW 201FDTVLIGLVL TVVSVCGDLL ESWLKRAAGI KDSSNLLPGH GGVFDRTDSL 251IAVISVYAAM MSVLN* m569/a569 99.6% identity in 265 aa overlap        10        20        30        40        50        60 m569.pepMLKQRVITAMWLLPLMLGMLFYAPQWLWAAFCGLIALIALWEYARMGGLCKIKTNHYLAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a569MLKQRVITAMWLLPLMLGMLFYAPQWLWAAFCGLIALIALWEYARMGGLCKIKTNHYLAA        10        20        30        40        50        60        70        80        90       100       110       120 m569.pepTLVFGVVAYAGGWMLPNLVWYVVLAFWLAVMPLWLRFKWRLNGGWQVYAVGWLLVMPFWF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a569TLVFGVVAYAGGWMLPNLVWYVVLAFWLAVMPLWLRFKWRLNGGWQVYAVGWLLVMPFWF        70        80        90       100       110       120       130       140       150       160       170       180 m569.pepALVSLRPHPDDALPLLAVMGLVWVADICAYFSGKAFGKHKIAPAISPGKSWEGAIGGAVC|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a569ALVSLRPHPDDALPLLAVMGLVWVADICAYFSGKAFGKHKIAPAISPGKSWEGAIGGAVC       130       140       150       160       170       180       190       200       210       220       230       240 m569.pepVAVYMTAVRSAGWLAFDTGWFDTVLIGLVLTVVSVCGDLLESWLKRAAGIKDSSKLLPGH||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| a569VAVYMTAVRSAGWLAFDTGWFDTVLIGLVLTVVSVCGDLLESWLKRAAGIKDSSNLLPGH       190       200       210       220       230       240       250       260 m569.pep GGVFDRTDSLIAVISVYAAMMSVLNX|||||||||||||||||||||||||| a569 GGVFDRTDSLIAVISVYAAMMSVLNX       250       260The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1701>:

g570.seq.. 1 atgatccgtt tgacccgcgc gtttgccgcc gccctgatcg gtttatgctg 51caccacaggc gcgcacgccg acaccttcca aaaaatcggc tttatcaaca 101ccgagcgcat ctacctcgaa tccaagcagg cgcgcaacat ccaaaaaacg 151ctggacggcg aattttccgc ccgtcaggac gaattgcaaa aactgcaacg 201cgaaggcttg gatttggaaa ggcagctcgc cggcggcaaa cttaaggacg 251caaaaaaggc gcaagccgaa gaaaaatggc gcgggctggt cgaagcgttc 301cgcaaaaaac aggcgcagtt tgaagaagac tacaacctcc gccgcaacga 351agagtttgcc tccctccagc aaaacgccaa ccgcgtcatc gtcaaaatcg 401ccaaacagga aggttacgat gtcattttgc aggacgtgat ttacgtcaac 451acccaatacg acgttaccga cagcgtcatt aaagaaatga acgcccgctg 501 aThis corresponds to the amino acid sequence <SEQ ID 1702; ORF 570.ng>:

g570.pep.. 1 MIRLTRAFAA ALIGLCCTTG AHADTFQKIG FINTERIYLE SKQARNIQKT 51LDGEFSARQD ELQKLQREGL DLERQLAGGK LKDAKKAQAE EKWRGLVEAF 101RKKQAQFEED YNLRRNEEFA SLQQNANRVI VKIAKQEGYD VILQDVIYVN 151TQYDVTDSVI KEMNAR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1703>:

m570.seq.. 1 ATGACCCGTT TGACCCGCGC GTTTGCCGCG GCTCTGATCG GTTTGTGCTG 51CACCGCAGGC GCGCACGCCG ACACCTTCCA AAAAATCGGC TTTATCAACA 101CCGAGCGCAT CTACCTCGAA TCCAAGCAGG CGCGCAAGAT TCAAAAAACG 151CTGGACAGCG AATTTTCCGC TCGTCAGGAC GAATTGCAAA AACTGCAACG 201CGAAGGTCTG GATTTGGAAA GGCAGCTTGC CGAAGGCAAA CTCAGAAACG 251CAAAAAAGGC GCAAGCCGAA GAAAAATGGC GCGGGCTGGT CGCAGCGTTC 301CGCAAAAAAC AGGCGCAGTT TGAAGAAGAC TACAACCTCC GCCGCAACGA 351AGAGTTTGCC TCCCTCCAGC AAAACGCCAA CCGCGTCATC GTCAAAATCG 401CCAAACAGGA AGGTTACGAT GTCATTTTGC AGAACGTGAT TTACGTCAAC 451ACCCAATACG ACGTTACCGA CAGCGTCATT AAAGAAATGA ACGCCCGCTG 501 AThis corresponds to the amino acid sequence <SEQ ID 1704; ORF 570>:

m570.pep 1 MTRLTRAFAA ALIGLCCTAG AHADTFQKIG FINTERIYLE SKQARKIQKT 51LDSEFSARQD ELQKLQREGL DLERQLAEGK LRNAKKAQAE EKWRGLVAAF 101RKKQAQFEED YNLRRNEEFA SLQQNANRVI VKIAKQEGYD VILQNVIYVN 151TQYDVTDSVI KEMNAR* m570/g570 94.6% identity in 166 aa overlap        10        20        30        40        50        60 m570.pepMTRLTRAFAAALIGLCCTAGAHADTFQKIGFINTERIYLESKQARKIQKTLDSEFSARQD |||||||||||||||||:||||||||||||||||||||||||||:||||||:||||||| g570MIRLTRAFAAALIGLCCTTGAHADTFQKIGFINTERIYLESKQARNIQKTLDGEFSARQD        10        20        30        40        50        60        70        80        90       100       110       120 m570.pepELQKLQREGLDLERQLAEGKLRNAKKAQAEEKWRGLVAAFRKKQAQFEEDYNLRRNEEFA||||||||||||||||| |||::||||||||||||| ||||||||||||||||||||||| g570ELQKLQREGLDLERQLAGGKLKDAKKAQAEEKWRGLVEAFRKKQAQFEEDYNLRRNEEFA        70        80        90       100       110       120       130       140       150       160 m570.pepSLQQNANRVIVKIAKQEGYDVILQNVIYVNTQYDVTDSVIKEMNARX||||||||||||||||||||||||:|||||||||||||||||||||| g570SLQQNANRVIVKIAKQEGYDVILQDVIYVNTQYDVTDSVIKEMNARX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1705>:

a570.seq 1 ATGACCCGTT TGACCCGCGC GTTTGCCGCG GCTCTGATCG GTTTGTGCTG 51CACCGCAGGC GCGCACGCCG ACACCTTCCA AAAAATCGGC TTTATCAACA 101CCGAGCGCAT CTACCTCGAA TCCAAGCAGG CGCGCAAGAT TCAAAAAACG 151CTGGACAGCG AATTTTCCGC CCGCCAGGAC GAATTGCAAA AACTGCAACG 201CGAAGGTCTG GATTTGGAAA GGCAGCTTGC CGAAGGCAAA CTCAAAGACG 251CAAAAAAGGC GCAAGCCGAA GAAAAATGGT GCGGGCTGGT CGCAGCGTTC 301CGCAAAAAAC AGGCGCAGTT TGAAGAAGAC TACAACCTCC GCCGCAACGA 351AGAGTTTGCC TCCCTCCAGC AAAACGCCAA CCGCGTCATC GTCAAAATCG 401CCAAACAGGA AGGTTACGAT GTCATTTTGC AGGACGTGAT TTACGTCAAC 451ACCCAATACG ACGTTACCGA CAGCGTCATT AAAGAAATGA ACGCCCGCTG 501 AThis corresponds to the amino acid sequence <SEQ ID 1706; ORF 570.a>:

a570.pep 1 MTRLTRAFAA ALIGLCCTAG AHADTFQKIG FINTERIYLE SKQARKIQKT 51LDSEFSARQD ELQKLQREGL DLERQLAEGK LKDAKKAQAE EKWCGLVAAF 101RKKQAQFEED YNLRRNEEFA SLQQNANRVI VKIAKQEGYD VILQDVIYVN 151TQYDVTDSVI KEMNAR* m570/a570 97.6% identity in 166 aa overlap        10        20        30        40        50        60 m570.pepMTRLTRAFAAALIGLCCTAGAHADTFQKIGFINTERIYLESKQARKIQKTLDSEFSARQD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a570MIRLTRAFAAALIGLCCIAGAHADTFQKIGFINTERIYLESKQARKIQKTLDSEFSARQD        10        20        30        40        50        60        70        80        90       100       110       120 m570.pepELQKLQREGLDLERQLAEGKLRNAKKAQAEEKWRGLVAAFRKKQAQFEEDYNLRRNEEFA|||||||||||||||||||||::|||||||||| |||||||||||||||||||||||||| a570ELQKLQREGLDLERQLAEGKLKDAKKAQAEEKWCGLVAAFRKKQAQFEEDYNLRRNEEFA        70        80        90       100       110       120       130        140        150        160 m570.pepSLQQNANRVIVKIAKQEGYDVILQNVIYVNTQYDVTDSVIKEMNARX||||||||||||||||||||||||:|||||||||||||||||||||| a570SLQQNANRVIVKIAKQEGYDVILQDVIYVNTQYDVTDSVIKEMNARX       130        140        150        160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1707>:

g571.seq (partial) 1atgcgcgttt tccgagtaaa ccgatttgtt gttaccgttt tcggcggcgg 51tataggttct gccgtcccac acgctgcctg cgtcggcaaa caggctcagg 101cggacggtgc gtgcgtcttt cgcaccgggc atcgggaaga gcagctcggc 151ggagacgttg gcttttttgt tgccgccgta gctgattttt tcgccgtatt 201cgtcatacac tttcgggccg agcgtgccgc tttcgtagcc gcgcaccgaa 251cccaggccgc cgccgtagaa gttttcaaag aaggggattt ctttggttct 301gccgtagccg cccgcaatgc cgacttcgcc gccgagcatc agcgtgaagg 351 ttttgct...This corresponds to the amino acid sequence <SEQ ID 1708; ORF 571.ng>:

g571.pep (partial) 1MRVFRVNRFV VTVFGGGIGS AVPHAACVGK QAQADGACVF RTGHREEQLG 51GDVGFFVAAV ADFFAVFVIH FRAERAAFVA AHRTQAAAVE VFKEGDFFGS 101AVAARNADFA AEHQREGFA...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1709>:

m571.seq 1 ATGGGTATTG CCGGCGCCGT AAATGTTTTG AACCCTGCCG CCGGTCGCGG 51AACTGCTGTT GTCGTCGTAG GTTTTGCCGT CCCACACGCT GCCTGCGTCG 101GCAAACAGGC TCAGGCGGAC GGTGCGCGCG TCTTTCGCGC CGGGCATCGG 151GAAGAGCAGC TCGGCGGAGA CGTTGGCTTT TTTGTTGCCG CCGTAGCTGA 201TTTTTTCGCC GTATTCGTCA TAGACTTTCG GACCGAGCGT GCCGCTTTCG 251TATCCGCGCA CCGAACCCAG GCCGCCGCCG TAGAAGTTTT CAAAGAAGGG 301GATTTCTTTG GTTCTGCCGT AGCCGCCCGC AATGCCGACT TCGCCGCCGA 351GCATCAGCGT GAAGGTTTTG CTCAGGGGGA AGAACCAGGT TTGGTTGTGG 401GTGGCGGAGT AGTATTGCAG TTTGCTGCCA GGCAGGGCGA TTTCGGCGTT 451CACGCCCGTC AGGTAGCCGC GCGTCGGCCA TAAThis corresponds to the amino acid sequence <SEQ ID 1710; ORF 571>:

m571.pep 1 MGIAGAVNVL NPAAGRGTAV VVVGFAVPHA ACVGKQAQAD GARVFRAGHR 51EEQLGGDVGF FVAAVADFFA VFVIDFRTER AAFVSAHRTQ AAAVEVFKEG 101DFFGSAVAAR NADFAAEHQR EGFAQGEEPG LVVGGGVVLQ FAARQGDFGV 151 HARQVAARRP *m571/g571 93.1% identity in 102 aa overlap        10        20        30        40        50        60 m571.pepMGIAGAVNVLNPAAGRGTAVVVVGFAVPHAACVGKQAQADGARVFRAGHREEQLGGDVGF                      :| ||||||||||||||||| g571     MRVFRVNRFVVTVFGGGIGSAVPHAACVGKQAQADGACVFRTGHREEQLGGDVGF             10        20        30        40        50        70        80        90       100       110       120 m571.pepFVAAVADFFAVFVIDFRTERAAFVSAHRTQAAAVEVFKEGDFFGSAVAARNADFAAEHQR|||||||||||||| ||:||||||:||||||||||||||||||||||||||||||||||| g571FVAAVADFFAVFVIHFRAERAAFVAAHRTQAAAVEVFKEGDFFGSAVAARNADFAAEHQR   60        70        80        90       100       110       130       140       150       160 m571.pepEGFAQGEEPGLVVGGGVVLQFAARQGDFGVHARQVAARRPX |||| g571 EGFA  119The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1711>:

a571.seq 1 ATGGGTATTG CCGGCGCCGT AAATGTTTTG AACCCTGCCG CCGGTCGCGG 51AACTGCTGTT GTCGTCGTAG GTTTTGCCGT CCCACACGCT GCCTGCGTCG 101GCAAACAGGC TCAGGCGGAC GGTGCGCGCG TCTTTCGCGC CGGGCATCGG 151GAAGAGCAGC TCGGCGGAGA CGTTGGCTTT TTTGTTGCCG CCGTAGCTGA 201TTTTTTCGCC GTATTCGTCA TACACTTTCG GACCGAGCGT GCCGCTTTCG 251TATCCGCGCA CCGAACCCAG GCCGCCGCCG TAGAAGTTTT CAAAGAAGGG 301GATTTCTTTG GTTCTGCCGT AGCCGCCCGC AATGCCGACT TCGCCGCCGA 351GCATCAGCGT GAAGGTTTTG CTTAAGGGGA AGAACCAGGT TTGGTTGTGG 401GTGGCGGAGT AGTATTGCAG TTTGCTGCCG GGCAGGGCGA TTTCGGCGTT 451CACGCCCGTC AGGTAGCCGC GCGTCGGCCA TAAThis corresponds to the amino acid sequence <SEQ ID 1712; ORF 571.a>:

a571.pep 1 MGIAGAVNVL NPAAGRGTAV VVVGFAVPHA ACVGKQAQAD GARVFRAGHR 51EEQLGGDVGF FVAAVADFFA VFVIHFRTER AAFVSAHRTQ AAAVEVFKEG 101DFFGSAVAAR NADFAAEHQR EGFA*GEEPG LVVGGGVVLQ FAAGQGDFGV 151 HARQVAARRP *m571/a571 98.1% identity in 160 aa overlap        10        20        30        40        50        60 m571.pepMGIAGAVNVLNPAAGRGTAVVVVGFAVPHAACVGKQAQADGARVFRAGHREEQLGGDVGF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a571MGIAGAVNVLNPAAGRGTAVVVVGFAVPHAACVGKQAQADGARVFRAGHREEQLGGDVGF        10        20        30        40        50        60        70        80        90       100       110       120 m571.pepFVAAVADFFAVFVIDFRTERAAFVSAHRTQAAAVEVFKEGDFFGSAVAARNADFAAEHQR|||||||||||||| ||||||||||||||||||||||||||||||||||||||||||||| a571FVAAVADFFAVFVIHFRTERAAFVSAHRTQAAAVEVFKEGDFFGSAVAARNADFAAEHQR        70        80        90       100       110       120       130       140       150       160 m571.pepEGFAQGEEPGLVVGGGVVLQFAARQGDFGVHARQVAARRPX |||| ||||||||||||||||||||||||||||||||||| a571 EGFAXGEEPGLVVGGGVVLQFAAGQGDFGVHARQVAARRPX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1713>:

g572.seq.. 1 atgtgcgcca tcgtcggggc ggcggggctg ccttccgcgc tcgcagcggc 51gcaaaaaggc aaaaccattt atctggcaaa caaagaaacg ctggtggttt 101ccggcgcgtt gtttatggaa accgcccgcg caaacggcgc ggcagtgttg 151cccgtcgaca gcgaacacaa cgccattttc caagttttgc cgcgcgatta 201cacagaccgt ctgaacgaac acggcatcga ttcgattatc ctgaccgctt 251ccggcggccc gtttttaaca accgatttaa gcacgttcga cagcattacg 301cccgagcagg cggtcaaaca ccccaattgg cgtatggggc gcaaaatctc 351cgtcgattca gccactatgg caaacaaggg cttggaactg attgaagcgc 401attggctgtt caactgtccg cccgacaaac tcgaagtcgt catccatccc 451caatccgtga tacacagtat ggtgcgctac cgcgacggct ccgtgctggc 501gcaactgggc aatcccgata tgcgaacgcc catcgcctat tgtttgggct 551tgcccgagcg catcgattcg ggtgtcggca aactcgattt cggcgcattg 601tccgcgctga ccttccaaaa gcccgacttc ggccgcttcc cctgcctgaa 651gttcgcctat gaaaccataa acgcaggcgg agccgcgccc tgcgtattga 701acgccgccaa cgaaaccgcc gtcgccgcct ttttggacgg acagattaag 751tttaccgaca ttgccaaaac cgtcgcccac tgtcttgcac aagacttttc 801aaacggcatg ggcgatatag aaggactgtt ggcgcaagat gcccggacac 851gcgcacaagc gcgggcattt atcggcacac tgcgctgaThis corresponds to the amino acid sequence <SEQ ID 1714; ORF 572.ng>:

g572.pep.. 1 MCAIVGAAGL PSALAAAQKG KTIYLANKET LVVSGALFME TARANGAAVL 51PVDSEHNAIF QVLPRDYTDR LNEHGIDSII LTASGGPFLT TDLSTFDSIT 101PEQAVKHPNW RMGRKISVDS ATMANKGLEL IEAHWLFNCP PDKLEVVIHP 151QSVIHSMVRY RDGSVLAQLG NPDMRTPIAY CLGLPERIDS GVGKLDFGAL 201SALTFQKPDF GRFPCLKFAY ETINAGGAAP CVLNAANETA VAAFLDGQIKThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1715>:

m572.seq.. 1 ATGTGCGCCA TCGTCGGGGC GGTGGGGCTG CCTTCCGCGC TCGCAGCGGC 51GCAAAAAGGC AAAACCATTT ATCTGGCAAA CAAAGAAACG CTGGTGGTTT 101CCGGCGCGTT GTTTATGGAA ACCGCCCGTG CAAACGGCGC GGCAGTGCTG 151CCCGTCGACA GCGAACACAA CGCCGTTTTC CAAGTTTTGC CGCGCGATTA 201CGCCGGCCGT CTGAACGAAC ACGGCATCGC TTCGATTATC CTGACCGCTT 251CCGGCGGCCC GTTTCTGACC GCCGATTTAA ACACGTTCGA CCGCATTACG 301CCCGCCCAAG CGGTCAAACA CCCCAATTGG CGTATGGGAC GCAAAATCTC 351CGTCGATTCC GCCACCATGA TGAACAAAGG TTTGGAGCTG ATTGAAGCGC 401ATTGGCTGTT CAACTGTCCG CCCGACAAAC TCGAAGTCGT CATCCATCCG 451CAATCCGTGA TACACAGCAT GGTGCGCTAC CGCGACGGCT CCGTGCTGGC 501GCAACTGGGC AATCCCGATA TGCGAACGCC CATCGCTTAT TGTTTGGGTT 551TGCCCGAGCG CATCGATTCG GGTGTCGGCG ACCTGGATTT CGACGCATTG 601TCCGCGCTGA CCTTCCAAAA GCCCGACTTT GACCGCTTCC CCTGCCTGAG 651GCTCGCCTAT GAAGCCATGA ACGCAGGCGG AGCCGCGCCC TGCGTATTGA 701ACGCCGCCAA CGAAGCCGCC GTCGCCGCCT TTTTGGACGG ACAGATTAAG 751TTTACCGACA TTGCCAAAAC CGTCGCCCAC TGTCTTGCAC AAGACTTTTC 801AGACGGCATA GGCGATATAG GGGGGCTCTT GGCGCAAGAT GCCCGGACAC 851GCGCACAAGC GCGAGCATTT ATCGGCACAC TGCGCTGAThis corresponds to the amino acid sequence <SEQ ID 1716; ORF 572>:

m572.pep.. 1 MCAIVGAVGL PSALAAAQKG KTIYLANKET LVVSGALFME TARANGAAVL 51PVDSEHNAVF QVLPRDYAGR LNEHGIASII LTASGGPFLT ADLNTFDRIT 101 PAQAVKHPNWRMGRKISVDS ATMMNKGLEL IEAHWLFNCP PDKLEVVIHP 151 QSVIHSMVRY RDGSVLAQLGNPDMRTPIAY CLGLPERIDS GVGDLDFDAL 201 SALTFQKPDF DRFPCLRLAY EAMNAGGAAPCVLNAANEAA VAAFLDGQIK 251 FTDIAKTVAH CLAQDFSDGI GDIGGLLAQD ARTRAQARAFIGTLR* m572/g572 92.9% identity in 295 aa overlap        10        20        30        40        50        60 m572.pepMCAIVGAVGLPSALAAAQKGKTIYLANKETLVVSGALFMETARANGAAVLPVDSEHNAVF|||||||:||||||||||||||||||||||||||||||||||||||||||||||||||:| g572MCAIVGAAGLPSALAAAQKGKTIYLANKETLVVSGALFMETARANGAAVLPVDSEHNAIF        10        20        30        40        50        60        70        80        90       100       110       120 m572.pepQVLPRDYAGRLNEHGIASIILTASGGPFLTADLNTFDRITPAQAVKHPNWRMGRKISVDS |||||||:||||||| |||||||||||||:||:||| ||| |||||||||||||||||| g572QVLPRDYTDRLNEHGIDSIILTASGGPFLTTDLSTFDSITPEQAVKHPNWRMGRKISVDS        70        80        90       100       110       120       130       140       150       160       170       180 m572.pepATMMNKGLELIEAHWLFNCPPDKLEVVIHPQSVIHSMVRYRDGSVLAQLGNPDMRTPIAY||| |||||||||||||||||||||||||||||||||||||||||||||||||||||||| g572ATMANKGLELIEAHWLFNCPPDKLEVVIHPQSVIHSMVRYRDGSVLAQLGNPDMRTPIAY       130       140       150       160       170       180       190       200       210       220       230       240 m572.pepCLGLPERIDSGVGDLDFDALSALTFQKPDFDRFPCLRLAYEAMNAGGAAPCVLNAANEAA||||||||||||| ||| |||||||||||| |||||::|||::|||||||||||||||:| g572CLGLPERIDSGVGKLDFGALSALTFQKPDFGRFPCLKFAYETINAGGAAPCVLNAANETA       190       200       210       220       230       240       250       260       270       280       290 m572.pepVAAFLDGQIKFTDIAKTVAHCLAQDFSDGIGDIGGLLAQDARTRAQARAFIGTLRX|||||||||||||||||||||||||||:|:||| |||||||||||||||||||||| g572VAAFLDGQIKFTDIAKTVAHCLAQDFSNGMGDIEGLLAQDARTRAQARAFIGTLRX       250       260       270       280       290The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1717>:

a572.seq 1 ATGTGCGCCA TCGTCGGGGC GGTGGGGCTG CCTTCCGCGC TCGCAGCGGC 51GCAAAAAGGC AAAACCATTT ATCTGGCGAA CAAAGAGACG CTGGTGGTTT 101 CCGGCGCGTTGTTTATGGAA ACCGCCCGTG CAAACGGCGC GGCAGTGCTG 151 CCCGTCGACA GCGAACACAACGCCGTTTTC CAAGTTTTGC CGCGCGATTA 201 CACAGGTCGC CTGAACGAAC ACGGCATCGCTTCGATTATC CTGACCGCTT 251 CCGGCGGCCC GTTTCTGACC GCCGATTTAA ACACGTTCGACAGCATTACG 301 CCCGACCAAG CGGTCAAACA CCCCAATTGG CGTATGGGAC GCAAAATCTC351 CGTCGATTCC GCCACCATGA TGAACAAAGG TTTGGAGCTG ATTGAAGCGC 401ATTGGCTGTT CAACTGTCCG CCCGACAAAC TCGAAGTCGT CATCCATCCG 451 CAATCTGTGATACACAGCAT GGTGCGCTAC CGCGACGGCT CCGTGTTGGC 501 GCAACTGGGC AATCCCGATATGCGAACGCC TATCGCTTAT TGTTTGGGTT 551 TGCCCGAGCG CATCGATTCG GGTGTCGGCGACCTGGATTT CGACGCATTG 601 TCCGCGCTGA CCTTCCAAAA GCCCGACTTT GACCGCTTCCCCTGCCTGAA 651 GCTCGCCTAT GAAGCCATGA ACGCAGGCGG AGCCGCGCCC TGCGTATTGA701 ACGCCGCCAA CGAAGCCGCC GTCGCCGCCT TTTTGGACGG ACAGATTAAG 751TTTACCGACA TTGCCAAAAC CGTCGCCCAT TGTCTTTCAC AAGACTTTTC 801 AGACGGCATAGGCGACATAG GGGGGCTCTT GGCGCAAGAT GCCCGGACAC 851 GCGCACAAGC GCGGGCATTTATCGGCACAC TGCGCTGAThis corresponds to the amino acid sequence <SEQ ID 1718; ORF 572.a>:

a572.pep 1 MCAIVGAVGL PSALAAAQKG KTIYLANKET LVVSGALFME TARANGAAVL 51PVDSEHNAVF QVLPRDYTGR LNEHGIASII LTASGGPFLT ADLNTFDSIT 101 PDQAVKHPNWRMGRKISVDS ATMMNKGLEL IEAHWLFNCP PDKLEVVIHP 151 QSVIHSMVRY RDGSVLAQLGNPDMRTPIAY CLGLPERIDS GVGDLDFDAL 201 SALTFQKPDF DRFPCLKLAY EAMNAGGAAPCVLNAANEAA VAAFLDGQIK 251 FTDIAKTVAH CLSQDFSDGI GDIGGLLAQD ARTRAQARAFIGTLR* m572/a572 98.3% identity in 295 aa overlap        10        20        30        40        50        60 m572.pepMCAIVGAVGLPSALAAAQKGKTIYLANKETLVVSGALFMETARANGAAVLPVDSEHNAVF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a572MCAIVGAVGLPSALAAAQKGKTIYLANKETLVVSGALFMETARANGAAVLPVDSEHNAVF        10        20        30        40        50        60        70        80        90       100       110       120 m572.pepQVLPRDYAGRLNEHGIASIILTASGGPFLTADLNTFDRITPAQAVKHPNWRMGRKISVDS|||||||:||||||||||||||||||||||||||||| ||| |||||||||||||||||| a572QVLPRDYTGRLNEHGIASIILTASGGPFLTADLNIFDSITPDQAVKHPNWRMGRKISVDS        70        80        90       100       110       120       130       140       150       160       170       180 m572.pepATMMNKGLELIEAHWLFNCPPDKLEVVIHPQSVIHSMVRYRDGSVLAQLGNPDMRTPIAY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a572ATMMNKGLELIEAHWLFNCPPDKLEVVIHPQSVIHSMVRYRDGSVLAQLGNPDMRTPIAY       130       140       150       160       170       180       190       200       210       220       230       240 m572.pepCLGLPERIDSGVGDLDFDALSALTFQKPDFDRFPCLRLAYEAMNAGGAAPCVLNAANEAA||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||| a572CLGLPERIDSGVGDLDFDALSALTFQKPDFDRFPCLKLAYEAMNAGGAAPCVLNAANEAA       190       200       210       220       230       240       250       260       270       280       290 m572.pepVAAFLDGQIKFTDIAKTVAHCLAQDFSDGIGDIGGLLAQDARTRAQARAFIGTLRX||||||||||||||||||||||:||||||||||||||||||||||||||||||||| a572VAAFLDGQIKFTDIAKTVAHCLSQDFSDGIGDIGGLLAQDARTRAQARAFIGILRX       250       260       270       280       290The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1719>:

g573.seq.. 1 atgccctgtt tgtgccgcct taatcgcaat atcggcagtt tccaaatcac 51gaatctcacc gaccataatg atgtccgggt cctgacgcag gaaagacttc 101 aaagcagcggcaaaagtcag accctgctta tcattgacgt taacctgatt 151 gatgcccggc aggttaatctcggcagggtc ttccgccgtt gcaatattta 201 ccgactccgt attcaaaata ttcaaacaggtatagagcga caccgtctta 251 cccgaacccg tcggaccggt taccagcacc atcccgtaaggacggtgaat 301 cgcttccaac aacaattttt tctggaacgg ctcaaaaccg agctggtcga351 tgttcaaaga cgcggcatcg gaattcaaaa tccgcatcac gaccttttcg 401ccaaacagcg tcggcaatgt gctgacacgg aaatcgacag gcttgccgcc 451 cttttgaaaggtcagctgca tcctaccgtc ctgcggtatc cgtttttcgg 501 aaatgtccaa acgcgacattaccttaatcc gggaagcaag ctgccccctt 551 accgcaatgg gcggctgaac cacctcgcggagctgcccgt ccacacggaa 601 acggatacgc gcattgtgtt cgtaaaactc gaaatggatgtcggatgccc 651 cgctacgcaa ggcatccgac aaagttttat ggataaacct cggaacaggg701 ccgtcttctg cctcctcgtc gtcgatatac agggtgtggc tttcctcttc 751ctcttgcccc tccccaagct cctgaagcag cgatgtcgaa cgcgaaccca 801 cccaatcgagcaaacccgcc aactggtcat cctcgacaat gaccaactca 851 accgcaatcc ctgcggcagaaaccgttttc tgaatttgcg gcatctgggt 901 cggatcggaa accgcaaaaa atactttgtcgcccccacgg aaaaccggca 951 cacagtggaa ctccaccatc tgctcctccg tcaacacccccatcagcacc 1001 ctgtggcgcg gataatgacg caaatcaaga atcgaataac tgaacaccct1051 cgcaatcaat gccgcaagcg acttgggcga aatgacaccg tctgaThis corresponds to the amino acid sequence <SEQ ID 1720; ORF 573.ng>:

g573.pep.. 1 MPCLCRLNRN IGSFQITNLT DHNDVRVLTQ ERLQSSGKSQ TLLIIDVNLI 51DARQVNLGRV FRRCNIYRLR IQNIQTGIER HRLTRTRRTG YQHHPVRTVN 101 RFQQQFFLERLKTELVDVQR RGIGIQNPHH DLFAKQRRQC ADTEIDRLAA 151 LLKGQLHPTV LRYPFFGNVQTRHYLNPGSK LPPYRNGRLN HLAELPVHTE 201 TDTRIVFVKL EMDVGCPATQ GIRQSFMDKPRNRAVFCLLV VDIQGVAFLF 251 LLPLPKLLKQ RCRTRTHPIE QTRQLVILDN DQLNRNPCGRNRFLNLRHLG 301 RIGNRKKYFV APTENRHTVE LHHLLLRQHP HQHPVARIMT QIKNRITEHP351 RNQCRKRLGR NDTV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1721>:

m573.seq.. 1 ATGCCCTGTT TGTGCCGCCT TAATCGCAAT ATCGGCAGTT TCCAAATCAC 51GAATCTCACC GACCATAATG ATGTCCGGGT CCTGACGCAG GAAAGACTTC 101 AAAGCAGCGGCAAAAGTCAG GCCCTGCTTA TCATTGACGT TAACCTGATT 151 GATGCCCGGC AGGTTAATCTCGGCAGGGTC TTCCGCCGTT GCAATATTTA 201 CCGACTCCGT ATTCAAAATA TTCAAACAGGTATAGAGCGA CACCGTCTTA 251 CCCGAACCCG TCGGACCGGT TACCAGCACC ATCCCGTAGGGACGGTGAAT 301 CGCTACCAAC aCaw.TTTTT TCTGAAACGG CTCAAAACCG AGCTGGTCGA351 TGTTCAAAGA CGCGGCATCG GAATTCAAAA TCCGCATCAC GACCTTTTCG 401CCAAACAGCG TCGGCAATGT GCTGACACGG AAATCGACAG GCTTGCCGCC 451 CTTTTGAAAGGTCAGCTGCA TCCTGCCGTC CTGCGGTATC CGTTTTTCGG 501 AAATGTCCAA ACGCGACATTACCTTAATCC GTGAAGCAAG CTGCCCCCTT 551 ACCGCAATGG GCGGCTGAAC CACCTCGCGGAGCTGCCCGT CCACACGGAA 601 ACGGATACGG GCATTGTGTT CGTAAAACTC GAAATGGATGTCCGATGCCC 651 CGCTGCGCAA GGCATCCGAC AAAGTCTTAT GGATAAACCT CGGAACAGGG701 CCGTCTTCTG CCTCCTCGTT GTCGATATAC AGGGTGTGGC TTTCCTCTTC 751CTCCTGCCCC TCCCCAAGCT CCTGAAGCAG CGATGTCGAA CGCGAACCCA 801 CCCAATCGAGCAAACCCGCC AACTGGTCAT CCTCGACAAT GACCAACTCA 851 ACCTCAATCC CTGCGGCAGAAACGGTTTTC TGAATTTGCG GCATCTGTGT 901 CGGATCGGAA ACCGCAAAAA ATACTTTGTCGCCCCGACGG AAAACCGGCA 951 CACAGTGGAA CTCCACCATC TGCTCCTCCG TCAACACCCCCATCAGCACC 1001 CTGTGGCGCG GATAATGACG CAAATCAAGA ATCGAATAAC TGAACACCCT1051 CGCAATCAAT GCCGCAAGCG ACTTGGGCGA AATGACACCG TCTGAThis corresponds to the amino acid sequence <SEQ ID 1722; ORF 573>:

m573.pep.. 1 MPCLCRLNRN IGSFQITNLT DHNDVRVLTQ ERLQSSGKSQ ALLIIDVNLI 51DARQVNLGRV FRRCNIYRLR IQNIQTGIER HRLTRTRRTG YQHHPVGTVN 101 RYQHXFFLKRLKTELVDVQR RGIGIQNPHH DLFAKQRRQC ADTEIDRLAA 151 LLKGQLHPAV LRYPFFGNVQTRHYLNP*SK LPPYRNGRLN HLAELPVHTE 201 TDTGIVFVKL EMDVRCPAAQ GIRQSLMDKPRNRAVFCLLV VDIQGVAFLF 251 LLPLPKLLKQ RCRTRTHPIE QTRQLVILDN DQLNLNPCGRNGFLNLRHLC 301 RIGNRKKYFV APTENRHTVE LHHLLLRQHP HQHPVARIMT QIKNRITEHP351 RNQCRKRLGR NDTV* m573/g573 95.9% identity in 364 aa overlap        10        20        30        40        50        60 m573.pepMPCLCRLNRNIGSFQITNLTDHNDVRVLTQERLQSSGKSQALLIIDVNLIDARQVNLGRV||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||| g573MPCLCRLNRNIGSFQITNLTDHNDVRVLTQERLQSSGKSQTLLIIDVNLIDARQVNLGRV        10        20        30        40        50        60        70        80        90       100       110       120 m573.pepFRRCNIYRLRIQNIQTGIERHRLTRTRRTGYQHHPVGTVNRYQHXFFLKRLKTELVDVQR|||||||||||||||||||||||||||||||||||| ||||:|: |||:||||||||||| g573FRRCNIYRLRIQNIQTGIERHRLTRTRRTGYQHHPVRTVNRFQQQFFLERLKTELVDVQR        70        80        90       100       110       120       130       140       150       160       170       180 m573.pepRGIGIQNPHHDLFAKQRRQCADTEIDRLAALLKGQLHPAVLRYPFFGNVQTRHYLNPXSK||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| || g573RGIGIQNPHHDLFAKQRRQCADTEIDRLAALLKGQLHPTVLRYPFFGNVQTRHYLNPGSK       130       140       150       160       170       180       190       200       210       220       230       240 m573.pepLPPYRNGRLNHLAELPVHTELDTGIVFVKLEMDVRCPAAQGIRQSLMDKPRNRAVFCLLV||||||||||||||||||||||| |||||||||| |||:||||||:|||||||||||||| g573LPPYRNGRLNHLAELPVHTELDTRIVFVKLEMDVGCPATQGIRQSFMDKPRNRAVFCLLV       190       200       210       220       230       240       250       260       270       280       290       300 m573.pepVDIQGVAFLFLLPLPKLLKQRCRTRTHPIEQTRQLVILDNDQLNLNPCGRNGFLNLRHLC|||||||||||||||||||||||||||||||||||||||||||| |||||| ||||||| g573VDIQGVAFLFLLPLPKLLKQRCRTRTHPIEQTRQLVILDNDQLNRNPCGRNRFLNLRHLG       250       260       270       280       290       300       310       320       330       340       350       360 m573.pepRIGNRKKYFVAPTENRHTVELHHLLLRQHPHQHPVARIMTQIKNRITEHPRNQCRKRLGR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g573RIGNRKKYFVAPTENRHTVELHHLLLRQHPHQHPVARIMTQIKNRITEHPRNQCRKRLGR       310       320       330       340       350       360 m573.pepNDTVX ||||| g573 NDTVXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1723>:

a573.seq 1 ATGCCCTGTT TGTGCCGCCT TAATCGCAAT ATCGGCAGTT TCCAAATCAC 51GAATCTCACC GACCATAATG ATGTCCGGGT CCTGACGCAG GAAAGACTTC 101 AAAGCAGCGGCAAAAGTCAG ACCCTGCTTA TCATTGACGT TAACCTGATT 151 GATGCCCGGC AGGTTAATCTCGGCAGGGTC TTCCGCCGTT GCAATATTTA 201 CCGACTCCGT ATTCAAAATA TTCAAACAGGTATAGAGCGA CACCGTCTTA 251 CCCGAACCCG TCGGACCGGT TACCAGCACC ATCCCGTAGGGACGGTGAAT 301 CGCTTCCAAC AACAATTTTT TCTGAAACGG CTCAAAACCG AGCTGGTCGA351 TGTTCAAAGA CGCGGCATCG GAATTCAAAA TCCGCATCAC GACCTTTTCG 401CCAAACAGCG TCGGCAATGT GCTGACACGG AAATCGACAG GCTTGCCGCC 451 CTTTTGAAAGGTCAGCTGCA TCCTGCCGTC CTGCGGTATC CGTTTTTCGG 501 AAATGTCCAA ACGCGACATTACCTTAATCC GGGAAGCAAG CTGCCCCCTT 551 ACCGCAATGG GCGGCTGAAC CACCTCGCGGAGCTGCCCGT CCACACGGAA 601 ACGGATACGG GCATTGTGTT CGTAAAACTC GAAATGGATGTCCGATGCCC 651 CGCTGCGCAA GGCATCCGAC AAAGTCTTAT GGATAAACCT CGGAACAGGG701 CCGTCTTCTG CCTCCTCGTT GTCGATATAC AGGGTGTGGC TTTCCTCTTC 751CTCCTGCCCC TCCCCAAGCT CCTGAAGCAG CGATGTCGAA CGCGAACCCA 801 CCCAATCGAGCAAACCCGCC AACTGGTCAT CCTCGACAAT GACCAACTCA 851 ACCTCAATCC CTGCGGCAGAAACGGTTTTC TGAATTTGCG GCATCTGTGT 901 CGGATCGGAA ACCGCAAAAA ATACTTTGTCGCCCCGACGG AAAACCGGCA 951 CACAGTGGAA CTCCACCATC TGCTCCTCCG TCAACACCCCCATCAGCACC 1001 CTGTGGCGCG GATAATGACG CAAATCAAGA ATCGAATAAC TGAACACCCT1051 CGCAATCAAT GCCGCAAGCG ACTTGGGCGA AATGACACCG TCTGAThis corresponds to the amino acid sequence <SEQ ID 1724; ORF 573.a>:

a573.pep 1 MPCLCRLNRN IGSFQITNLT DHNDVRVLTQ ERLQSSGKSQ TLLIIDVNLI 51DARQVNLGRV FRRCNIYRLR IQNIQTGIER HRLTRTRRTG YQHHPVGTVN 101 RFQQQFFLKRLKTELVDVQR RGIGIQNPHH DLFAKQRRQC ADTEIDRLAA 151 LLKGQLHPAV LRYPFFGNVQTRHYLNPGSK LPPYRNGRLN HLAELPVHTE 201 TDTGIVFVKL EMDVRCPAAQ GIRQSLMDKPRNRAVFCLLV VDIQGVAFLF 251 LLPLPKLLKQ RCRTRTHPIE QTRQLVILDN DQLNLNPCGRNGFLNLRHLC 301 RIGNRKKYFV APTENRHTVE LHHLLLRQHP HQHPVARIMT QIKNRITEHP351 RNQCRKRLGR NDTV* m573/a573 98.6% identity in 364 aa overlap        10        20        30        40        50        60 m573.pepMPCLCRLNRNIGSFQITNLTDHNDVRVLTQERLQSSGKSQALLIIDVNLIDARQVNLGRV||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||| a573MPCLCRLNRNIGSFQITNLTDHNDVRVLTQERLQSSGKSQTLLIIDVNLIDARQVNLGRV        10        20        30        40        50        60        70        80        90       100       110       120 m573.pepFRRCNIYRLRIQNIQTGIERHRLTRTRRTGYQHHPVGTVNRYQHXFFLKRLKTELVDVQR|||||||||||||||||||||||||||||||||||||||||:|: ||||||||||||||| a573FRRCNIYRLRIQNIQTGIERHRLTRTRRTGYQHHPVGTVNRFQQQFFLKRLKTELVDVQR        70        80        90       100       110       120       130       140       150       160       170       180 m573.pepRGIGIQNPHHDLFAKQRRQCADTEIDRLAALLKGQLHPAVLRYPFFGNVQTRHYLNPXSK||||||||||||||||||||||||||||||||||||||||||||||||||||||||| || a573RGIGIQNPHHDLFAKQRRQCADTEIDRLAALLKGQLHPAVLRYPFFGNVQTRHYLNPGSK       130       140       150       160       170       180       190       200       210       220       230       240 m573.pepLPPYRNGRLNHLAELPVHTETDTGIVFVKLEMDVRCPAAQGIRQSLMDKPRNRAVFCLLV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a573LPPYRNGRLNHLAELPVHTETDTGIVFVKLEMDVRCPAAQGIRQSLMDKPRNRAVFCLLV       190       200       210       220       230       240       250       260       270       280       290       300 m573.pepVDIQGVAFLFLLPLPKLLKQRCRTRTHPIEQTRQLVILDNDQLNLNPCGRNGFLNLRHLC|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a573VDIQGVAFLFLLPLPKLLKQRCRTRTHPIEQTRQLVILDNDQLNLNPCGRNGFLNLRHLC       250       260       270       280       290       300       310       320       330       340       350       360 m573.pepRIGNRKKYFVAPTENRHTVELHHLLLRQHPHQHPVARIMTQIKNRITEHPRNQCRKRLGR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a573RIGNRKKYFVAPTENRHTVELHHLLLRQHPHQHPVARIMTQIKNRITEHPRNQCRKRLGR       310       320       330       340       350       360 m573.pepNDTVX ||||| a573 NDTVXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1725>:

g574.seq 1 atgctgccga atctgccaaa cagccttaag aaagccgata tggacaacga 51attgtggatt atcctgctgc cgattatcct tttgcccgtc ttcttcacga 101 tgggctggtttgccgcccgc gtggatatga aaaccgtatt gaagcaggca 151 aaaagcatcc cttcgggattttataaaagc ctggacgctt tggtcgaccg 201 caacagcggg cgcgcggcaa gggagttggcggaagtcgtc gacggccggc 251 cgcaatcgta tgatttgaac cttaccctcg gcaaactttaccgtcagcgc 301 ggcgaaaacg acaaagccat caacatacac cggacaatgc tcgattctcc351 cgatacggtc ggcgaaaagc gcgcgcgcgt cctgtttgaa ttggcgcaaa 401actaccaaag cgcgggtttg gtcgatcgtg ccgaacagat ttttttgggg 451 ctgcaagacggtgaaatggc gcgtgaagcc agacagcacc tgctcaatat 501 ctaccagcag gacagggattgggaaaaagc ggttgaaacc gcccaacttc 551 ttagtcacga cgaacagaca tatcagtttgagattgcaca gttttattgc 601 gaacttgccc aagccgcgct gttcaagtcc aatttcgatgccgcgcgttt 651 caatgtcggc aaggcactcg aagccaacaa aaaatgcacc cgcgccaaca701 tgattttggg cgacattgaa caccgacaag gcaatttccc tgccgccgtc 751gaagcctatg ccgccatcga gcagcaaaac catgcatact tgagcatggt 801 cggcgagaagctttacgaag cctatgccgc gcagggaaaa cctgaagaag 851 gcttgaaccg tctgacaggatatatgcaga cgtttcccga acttgacctg 901 atcaatgtcg tgtacgagaa atccctgctgcttaagggcg agaaagaagc 951 cgcgcaaacc gccgtcgagc ttgtccgccg caagcccgaccttaacggcg 1001 tgtaccgcct gctcggtttg aaactcagcg atttggatcc ggcttggaaa1051 gccgatgccg acatgatgcg ttcggttatc ggacggcagc tccagcgcag 1101cgtgatgtac cgttgccgca actgccactt caaatcccaa gtctttttct 1151 ggcactgtcccgcctgcaac aaatggcaga cgtttacgcc gaataaaatc 1201 gaagtttaaThis corresponds to the amino acid sequence <SEQ ID 1726; ORF 574.ng>:

g574.pep.. 1 MLPNLPNSLK KADMDNELWI ILLPIILLPV FFTMGWFAAR VDMKTVLKQA 51KSIPSGFYKS LDALVDRNSG RAARELAEVV DGRPQSYDLN LTLGKLYRQR 101 GENDKAINIHRTMLDSPDTV GEKRARVLFE LAQNYQSAGL VDRAEQIFLG 151 LQDGEMAREA RQHLLNIYQQDRDWEKAVET AQLLSHDEQT YQFEIAQFYC 201 ELAQAALFKS NFDAARFNVG KALEANKKCTRANMILGDIE HRQGNFPAAV 251 EAYAAIEQQN HAYLSMVGEK LYEAYAAQGK PEEGLNRLTGYMQTFPELDL 301 INVVYEKSLL LKGEKEAAQT AVELVRRKPD LNGVYRLLGL KLSDLDPAWK351 ADADMMRSVI GRQLQRSVMY RCRNCHFKSQ VFFWHCPACN KWQTFTPNKI 401 EV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1727>:

m574.seq.. 1 ATGCGCCCGA ATCTACCAAA CAGCCTTAAG AAAGCCGATA TGGACAACGA 51ATTGTGGATT ATCCTGCTGC CGATTATCCT TTTGCCCGTC TTCTTCGCGA 101 TGGGCTGGTTTGCCGCCCGC GTGGATATGA AAACCGTATT GAAGCAGGCA 151 AAAAGCATCC CTTCGGGATTTTATAAAAGC TTGGACGCTT TGGTCGACCG 201 CAACAGCGGG CGCGCGGCAA GGGAGTTGGCGGAAGTCGTC GACGGCCGGC 251 CGCAATCGTA TGATTTGAAC CTCACCCTCG GCAAACTTTACCGCCAGCGT 301 GGCGAAAACG ACAAAGCCAT CAACATACAC CGGACAATGC TCGATTCTCC351 CGATACGGTC GGCGAAAAGC GCGCGCGCGT CCTGTTTGAA TTGGCGCAAA 401ACTACCAAAG TGCGGGGTTG GTCGATCGTG CCGAACAGAT TTTTTTGGGG 451 CTGCAAGACGGTAAAATGGC GCGTGAAGCC AGACAGCACC TGCTCAATAT 501 CTACCAACAG GACAGGGATTGGGAAAAAGC GGTTGAAACC GCCCGGCTGC 551 TCAGCCATGA CGATCAGACC TATCAGTTTGAAATCGCCCA GTTTTATTGC 601 GAACTTGCCC AAGCCGCGCT GTTCAAGTCC AATTTCGATGTCGCGCGTTT 651 CAATGTCGGC AAGGCACTCG AAGCCAACAA AAAATGCACC CGCGCCAACA701 TGATTTTGGG CGACATCGAA CACCGACAAG GCAATTTCCC TGCCGCCGTC 751GAAGCCTATG CCGCCATCGA GCAGCAAAAC CATGCATACT TGAGCATGGT 801 CGGCGAGAAGCTTTACGAAG CCTATGCCGC GCAGGGAAAA CCTGAAGAAG 851 GCTTGAACCG TCTGACAGGATATATGCAGA CGTTTCCCGA ACTTGACCTG 901 ATCAATGTCG TGTACGAGAA ATCCCTGCTGCTTAAGTGCG AGAAAGAAGC 951 CGCGCAAACC GCCGTCGAGC TTGTCCGCCG CAAGCCCGACCTTAACGGCG 1001 TGTACCGCCT GCTCGGTTTG AAACTCAGCG ATATGAATCC GGCTTGGAAA1051 GCCGATGCCG ACATGATGCG TTCGGTTATC GGACGGCAGC TACAGCGCAG 1101CGTGATGTAC CGTTGCCGCA ACTGCCACTT CAAATCCCAA GTCTTTTTCT 1151 GGCACTGCCCCGCCTGCAAC AAATGGCAGA CGTTTACCCC GAATAAAATC 1201 GAAGTTTAAThis corresponds to the amino acid sequence <SEQ ID 1728; ORF 574>:

m574.pep.. 1 MRPNLPNSLK KADMDNELWI ILLPIILLPV FFAMGWFAAR VDMKTVLKQA 51KSIPSGFYKS LDALVDRNSG RAARELAEVV DGRPQSYDLN LTLGKLYRQR 101 GENDKAINIHRTMLDSPDTV GEKRARVLFE LAQNYQSAGL VDRAEQIFLG 151 LQDGKMAREA RQHLLNIYQQDRDWEKAVET ARLLSHDDQT YQFEIAQFYC 201 ELAQAALFKS NFDVARFNVG KALEANKKCTRANMILGDIE HRQGNFPAAV 251 EAYAAIEQQN HAYLSMVGEK LYEAYAAQGK PEEGLNRLTGYMQTFPELDL 301 INVVYEKSLL LKCEKEAAQT AVELVRRKPD LNGVYRLLGL KLSDMNPAWK351 ADADMMRSVI GRQLQRSVMY RCRNCHFKSQ VFFWHCPACN KWQTFTPNKI 401 EV*m573/g573 97.8% identity in 402 aa overlap        10        20        30        40        50        60 m574.pepMRPNLPNSLKKADMDNELWIILLPIILLPVFFAMGWFAARVDMKTVLKQAKSIPSGFYKS| ||||||||||||||||||||||||||||||:||||||||||||||||||||||||||| g574MLPNLPNSLKKADMDNELWIILLPIILLPVFFTMGWFAARVDMKTVLKQAKSIPSGFYKS        10        20        30        40        50        60        70        80        90       100       110       120 m574.pepLDALVDRNSGRAARELAEVVDGRPQSYDLNLTLGKLYRQRGENDKAINIHRTMLDSPDTV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g574LDALVDRNSGRAARELAEVVDGRPQSYDLNLTLGKLYRQRGENDKAINIHRTMLDSPDTV        70        80        90       100       110       120       130       140       150       160       170       180 m574.pepGEKRARVLFELAQNYQSAGLVDRAEQIFLGLQDGKMAREARQHLLNIYQQDRDWEKAVET||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||| g574GEKRARVLFELAQNYQSAGLVDRAEQIFLGLQDGEMAREARQHLLNIYQQDRDWEKAVET       130       140       150       160       170       180       190       200       210       220       230       240 m574.pepARLLSHDDQTYQFEIAQFYCELAQAALFKSNFDVARFNVGKALEANKKCTRANMILGDIE|:|||||:|||||||||||||||||||||||||:|||||||||||||||||||||||||| g574AQLLSHDEQTYQFEIAQFYCELAQAALFKSNFDAARFNVGKALEANKKCTRANMILGDIE       190       200       210       220       230       240       250       260       270       280       290       300 m574.pepHRQGNFPAAVEAYAAIEQQNHAYLSMVGEKLYEAYAAQGKPEEGLNRLTGYMQTFPELDL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g574HRQGNFPAAVEAYAAIEQQNHAYLSMVGEKLYEAYAAQGKPEEGLNRLTGYMQTFPELDL       250       260       270       280       290       300       310       320       330       340       350       360 m574.pepINVVYEKSLLLKCEKEAAQTAVELVRRKPDLNGVYRLLGLKLSDMNPAWKADADMMRSVI|||||||||||| |||||||||||||||||||||||||||||||::|||||||||||||| g574INVVYEKSLLLKGEKEAAQTAVELVRRKPDLNGVYRLLGLKLSDLDPAWKADADMMRSVI       310       320       330       340       350       360       370       380       390       400 m574.pepGRQLQRSVMYRCRNCHFKSQVFFWHCPACNKWQTFTPNKIEVX||||||||||||||||||||||||||||||||||||||||||| g574GRQLQRSVMYRCRNCHFKSQVFFWHCPACNKWQTFTPNKIEVX       370       380       390       400The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1729>:

a574.seq 1 ATGCGCCCGA ATCTGCCAAA CAGCCTTGAG AAAGCCGATA TGGACAATGA 51ATTGTGGATT ATCCTGCTGC CGATTATCCT TTTGCCCGTT TTCTTCGCGA 101 TGGGCTGGTTTGCCGCCCGC GTGGATATGA AGACTGTATT AAAGCAGGCA 151 AAAAGCATAC CGTCGGGATTTTATAAAAGT CTGGATGCCT TGGTTGACCG 201 CAACAGCGGG CGCGCGGCAA GGGAGTTGGCGGAAGTCGTC GACGGCCGGC 251 CGCAATCGTA TGATTTGAAC CTCACCCTCG GCAAACTTTACCGCCAGCGT 301 GGCGAAAACG ACAAAGCCAT CAATATGCAC CAAACATTGC TTGACTCTCC351 CGATACAACC GGAGCCAAGC GCGCGCGCGT CCTGTTTGAA TTGGCGCAAA 401ACTACCAAAG TGCGGGGTTG GTCGATCGTG CCGAACAGAT TTTTTTGGGG 451 CTGCAAGACGGTGAAATGGC GCGTGAAGCC AGACAGCACC TGCTCAATAT 501 CTACCAACAG GACAGGGATTGGGAAAAAGC GGTTGAAACC GCCCGGCTGC 551 TCAGCCATGA CGATCAGACC TATCAGTTTGAAATCGCCCA GTTTTATTGC 601 GAACTTGCCC AAGCCGCGCT GTTCAAGTCC AATTTCGATGCCGCGCGTTT 651 CAATGTCGGC AAGGCACTCG AAGCCAACAA AAAATGCACC CGCGCCAACA701 TGATTTTGGG CGACATCGAA CACCGACAAG GCAATTTCCC TGCCGCCGTC 751GAAGCCTATG CCGCCATCGA GCAGCAAAAC CATGCATACT TGAGTATGGT 801 CGGCGAGAAGCTTTACGAAG CCTATGCCGC GCAGGGAAAA CCTGAAGAAG 851 GCTTGAACCG TCTGACAGGATATATGCAGA CGTTTCCCGA ACTTGACCTG 901 ATCAATGTCG TGTACGAGAA ATCCCTGCTGCTTAAGTGCG AGAAAGAAGC 951 CGCGCAAACC GCCGTCGAGC TTGTCCGCCG CAAGCCCGACCTCAACGGCG 1001 TGTACCGCCT GCTTGGTTTG AAACTCAGCG ATTTGGATCC GGCTTGGAAA1051 GCCGATGCCG ATATGATGCG TTCGGTTATC GGACGGCAGC TACAGCGCAG 1101CGTGATGTAC CGGTGCCGAA ACTGCCACTT CAAATCACAA GTCTTTTTCT 1151 GGCATTGTCCTGCCTGCAAC AAATGGCAGA CGTTTACGCC AAACAAAATC 1201 GAAGTTTAAThis corresponds to the amino acid sequence <SEQ ID 1730; ORF 574.a>:

a574.pep 1 MRPNLPNSLE KADMDNELWI ILLPIILLPV FFAMGWFAAR VDMKTVLKQA 51KSIPSGFYKS LDALVDRNSG RAARELAEVV DGRPQSYDLN LTLGKLYRQR 101 GENDKAINMHQTLLDSPDTT GAKRARVLFE LAQNYQSAGL VDRAEQIFLG 151 LQDGEMAREA RQHLLNIYQQDRDWEKAVET ARLLSHDDQT YQFEIAQFYC 201 ELAQAALFKS NFDAARFNVG KALEANKKCTRANMILGDIE HRQGNFPAAV 251 EAYAAIEQQN HAYLSMVGEK LYEAYAAQGK PEEGLNRLTGYMQTFPELDL 301 INVVYEKSLL LKCEKEAAQT AVELVRRKPD LNGVYRLLGL KLSDLDPAWK351 ADADMMRSVI GRQLQRSVMY RCRNCHFKSQ VFFWHCPACN KWQTFTPNKI 401 EV*m574/a574 97.5% identity in 402 aa overlap        10        20        30        40        50        60 m574.pepMRPNLPNSLKKADMDNELWIILLPIILLPVFFAMGWFAARVDMKTVLKQAKSIPSGFYKS|||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||| a574MRPNLPNSLEKADMDNELWIILLPIILLPVFFAMGWFAARVDMKTVLKQAKSIPSGFYKS        10        20        30        40        50        60        70        80        90       100       110       120 m574.pepLDALVDRNSGRAARELAEVVDGRPQSYDLNLTLGKLYRQRGENDKAINIHRTMLDSPDTV||||||||||||||||||||||||||||||||||||||||||||||||:|:|:||||||: a574LDALVDRNSGRAARELAEVVDGRPQSYDLNLTLGKLYRQRGENDKAINMHQTLLDSPDTT        70        80        90       100       110       120       130       140       150       160       170       180 m574.pepGEKRARVLFELAQNYQSAGLVDRAEQIFLGLQDGKMAREARQHLLNIYQQDRDWEKAVET| ||||||||||||||||||||||||||||||||:||||||||||||||||||||||||| a574GAKRARVLFELAQNYQSAGLVDRAEQIFLGLQDGEMAREARQHLLNIYQQDRDWEKAVET       130       140       150       160       170       180       190       200       210       220       230       240 m574.pepARLLSHDDQTYQFEIAQFYCELAQAALFKSNFDVARFNVGKALEANKKCTRANMILGDIE|||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||| a574ARLLSHDDQTYQFEIAQFYCELAQAALFKSNFDAARFNVGKALEANKKCTRANMILGDIE       190       200       210       220       230       240       250       260       270       280       290       300 m574.pepHRQGNFPAAVEAYAAIEQQNHAYLSMVGEKLYEAYAAQGKPEEGLNRLTGYMQTFPELDL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a574HRQGNFPAAVEAYAAIEQQNHAYLSMVGEKLYEAYAAQGKPEEGLNRLTGYMQTFPELDL       250       260       270       280       290       300       310       320       330       340       350       360 m574.pepINVVYEKSLLLKCEKEAAQTAVELVRRKPDLNGVYRLLGLKLSDMNPAWKADADMMRSVI||||||||||||||||||||||||||||||||||||||||||||::|||||||||||||| a574INVVYEKSLLLKCEKEAAQTAVELVRRKPDLNGVYRLLGLKLSDLDPAWKADADMMRSVI       310       320       330       340       350       360       370       380       390       400 m574.pepGRQLQRSVMYRCRNCHFKSQVFFWHCPACNKWQTFTPNKIEVX||||||||||||||||||||||||||||||||||||||||||| a574GRQLQRSVMYRCRNCHFKSQVFFWHCPACNKWQTFTPNKIEVX       370       380       390       400The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1731>:

g575.seq (partial) 1..atgccgtgcc tccgccggca agcagcaagg tgtacgaacc gccgaacaga 51  ccgtcaaaca gtccgctttc ggtttcttct tcggcagaaa cctgttcgac 101  aggttcggca acgggttcgg cggcaacttc actggctgtt tccgcaacag 151  gttcggaaac ggtgttaccg gtttcgtcgg tcggcgtgtc gatggcagaa 201  gcggcggctt cttggggggg cggattcggc agcggtttcc gatgcggcag 251  tatttgcagc gggtacaggt ccgggttggc gttctgtcgc cgaagccgga 301  gtttcggaca ctgcgggttt gggttcgggt cgaacggccg gtttttccgc 351  ttttgcttcg ggcgcggcaa cttttgcttc aggtttttca accggttttt 401  cgacaggttt ctctatcggt ttctccacag ttgcctgttt ggacggttca 451  gacggcatgg atgcagtttc ggctttgggt ttcgccgttt gcggtttggg 501  ttgttccgct ttgatttttt tgggtgctgc cgctttgatc ctgttcagat 551  tcggaatgtg a*This corresponds to the amino acid sequence <SEQ ID 1732; ORF 575.ng>:

g575.pep (partial) 1..MPCLRRQAAR CTNRRTDRQT VRFRFLLRQK PVRQVRQRVR RQLHWLFPQQ 51  VRKRCYRFRR SACRWQKRRL LGGADSAAVS DAAVFAAGTG PGWRSVAEAG 101  VSDTAGLGSG RTAGFSAFAS GAATFASGFS TGFSTGFSIG FSTVACLDGS 151  DGMDAVSALG FAVCGLGCSA LIFLGAAALI LFRFGM*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1733>:

m575.seq.. 1 ATGGTTTCGG GCGAGGAAGC CTTCAGGAAG CCTGCCAGTC CGGAGGGTGA 51GGCAGGTTTT GCGGAAGCTG TTTCTTCTGT GCCGATATGG TTGTTTGAGG 101GCAGGTTGTC GGAGAAATCG GTATCGACGG TTTCCGGTTT GTTTTCGGCA 151GTTTGGGCGA CAGATTCCGG TTCGGGCGTG TCGATGACGA TTTCGACAGG 201GTTGTACGGG TTGAAGGTCT CGGGCTCGTA CACGCTGTCT GTGGATTCGA 251TGGCGTTCCA ATCGGCATCC GCGCGTTTTT GGGTTTCTTC ATCCTGCGTA 301AGTGCGCCGG ATAAAATGCC GTTTTGCGCG GCTGCCAGGC TGTCGAAATC 351CAAGTCGATG CGGTTGGAAG GCGTATCGGT TTCGACATCG AACGTTTGTT 401TTGCCGATAA CTCTTCTTCA GATTCCCCAT CTAAGGCAAG TGTGTCGTTT 451ACATCGTTTT TCGGAGCGGG TTCGGGCGTT GCCGGAGTTT CGACTTCGGC 501AAAGGTGATT TCTATGCCGT CGTCTGCCGC GTCGTCAAGG TCAGGCTCTT 551CCTCAGGGAC GGATTCTTCG GTACGGCGCG CGCGTTTGGA TTGGGCAAGG 601CGCAAAAGCA GCAGCAGGGC GATTAATGCC GCGCCTCCGC CGGCAAGCAG 651CAAGGTGTAC GAACCGCCGA ACAGACCGTC AAACAGTCCG CTTTCGGTTT 701CTTCTTCGGC AGAAACCTGT TCGACAGGTT CGGAAACGGC GTTACCGGTT 751TCGTCGGTCG GCGTGTCGAT GGCAGAAGCG GCGGCTTCTT GGGGGGCGGA 801TTCGGCAGCG GTTTCCGATG CGGCAGTATT TGCAGCGGGT ACAGGTTCGG 851GTCGAACGGC CGGTTTTTCC GCTTTTGCTT CGGGCGCGGC AACTTTTGCT 901TCAGGTTTTT CAACCGGTTT CTCTACCGTT GCCTGTTTGG ACGGTTCGGA 951CGGCATGGAT GCGGTTTCGG CTTTGGGTTT CGCCGTTTGC GGTTTGGGTT 1001GTTCCGCTTT GATCCTGTTC AGATTCGGAA TGTGAThis corresponds to the amino acid sequence <SEQ ID 1734; ORF 575>:

m575.pep 1 MVSGEEAFRK PASPEGEAGF AEAVSSVPIW LFEGRLSEKS VSTVSGLFSA 51VWATDSGSGV SMTISTGLYG LKVSGSYTLS VDSMAFQSAS ARFWVSSSCV 101SAPDKMPFCA AARLSKSKSM RLEGVSVSTS NVCFADNSSS DSPSKASVSF 151TSFFGAGSGV AGVSTSAKVI SMPSSAASSR SGSSSGTDSS VRRARLDWAR 201RKSSSRAINA APPPASSKVY EPPNRPSNSP LSVSSSAETC STGSETALPV 251SSVGVSMAEA AASWGADSAA VSDAAVFAAG TGSGRTAGFS AFASGAATFA 301SGFSTGFSTV ACLDGSDGMD AVSALGFAVC GLGCSALILF RFGM* m575/g57570.2% identity in 114 aa overlap    240       250       260       270       280 m575.pep SSAETCSTGSETALPVSSVGVSMAEAAASWGADSAAVSDAAVFAAGTG------------                               |||||||||||||||||| g575 LHWLFPQQVRKRCYRFRRSACRWQKRRLLGGADSAAVSDAAVFAAGTGPGWRSVAEAGVS       50        60        70        80        90       100            290       300      309      310       320 m575.pep ------SGRTAGFSAFASGAATFASGFSTGFST--------VACLDGSDGMDAVSALGFA       |||||||||||||||||||||||||||        ||||||||||||||||||| g575 DTAGLGSGRTAGFSAFASGAATFASGFSTGFSTGFSIGFSTVACLDGSDGMDAVSALGFA      110       120       130       140       150       160330               340 m575.pep  VCGLGCSALI--------LFRFGMX  ||||||||||       ||||||| g575  VCGLGCSALIFLGAAALILFRFGMX       170       180The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1735>:

a575.seq 1 ATGGTTTCGG GCGAGGAAGC CTTCAGGAAG CCTGCCAGTC CGGAGGGTGA 51GGCAGGTTTT GCGGAAGCTG TTTCTTCTGT GCCGATATGG TTGTTTGAGG 101GCAGGTTGTC GGAGAAATCG GTATCGACGG TTTCCGGTTT GTTTTCGGCA 151GTTTGGGCGA CAGATTCCGG TTCGGGCGTG TCGATGACGA TTTCGACAGG 201GTTGTACGGG TTGAAGGTCT CGGGCTCGTA CACGCTGTCT GTGGATTCGA 251TGGCGTTCCA ATCGGCATCC GCGCGTTTTT GGGTTTCTTC ATCCTGCGTA 301AGTGCGCCGG ATAAAATGCC GTTTTGCGCG GCTGCCAGGC TGTCGAAATC 351CAAGTCGATG CGGTTGGAAG GCGTATCGGT TTCGACATCG AACGTTTGTT 401TTGCCGACAA CTCTTCTTCA GATTCCCCAT CTAAGGCAAG TGTGTCGTTT 451ACATCGTTTT TCGGAGCGGG TTCGGGCGTT GCCGGAGTTT CGACTTCGGC 501AAAGGTGATT TCTATGCCGT CGTCTGCCGC GTCGTCAAGG TCAGGCTCTT 551CCTCAGGGAC GGATTCTTCG GTACGGCGCG CGCGTTTGGA TTGGGCAAGG 601CGCAAAAGCA GCAGCAGGGC GATCAATGCC GCGCCTCCGC CGGCAAGCAG 651CAAGGTGTAC GAACCGCCGA ACAGTCCGCT TTCGGTTTCT TCTTCGGCAG 701AAACCTGTTC GACAGGTTCG GAAACGGCGT TACCGGTTTC GTCGGTCGGC 751GTGTCGATGG CAGAAGCGGC GGCTTCTTGG GGGGCGGATT CGGCAGCGGT 801TTCCGATGCG GCAGTATTTG CAGCGGGTAC AGGTTCGGGT CGAACGGCCG 851GTTTTTCCGC TTTTGCTTCG GGCGCGGCAA CTTTTGCTTC AGGTTTTTCA 901ACCGGTTTCT CTACCGTTGC CTGTTTGGAC GGTTCGGACG GCATGGATGC 951GGTTTCGGCT TTGGGTTTCG CCGTTTGCGG TTTGGGTTGT TCCGCTTTGA 1001TCCTGTTCAG ATTCGGAATG TGAThis corresponds to the amino acid sequence <SEQ ID 1736; ORF 575.a>:

a575.pep 1 MVSGEEAFRK PASPEGEAGF AEAVSSVPIW LFEGRLSEKS VSTVSGLFSA 51VWATDSGSGV SMTISTGLYG LKVSGSYTLS VDSMAFQSAS ARFWVSSSCV 101SAPDKMPFCA AARLSKSKSM RLEGVSVSTS NVCFADNSSS DSPSKASVSF 151TSFFGAGSGV AGVSTSAKVI SMPSSAASSR SGSSSGTDSS VRRARLDWAR 201RKSSSRAINA APPPASSKVY EPPNSPLSVS SSAETCSTGS ETALPVSSVG 251VSMAEAAASW GADSAAVSDA AVFAAGTGSG RTAGFSAFAS GAATFASGFS 301TGFSTVACLD GSDGMDAVSA LGFAVCGLGC SALILFRFGM * m575/a57598.8% identity in 344 aa overlap        10        20        30        40        50        60 m575.pepMVSGEEAFRKPASPEGEAGFAEAVSSVPIWLFEGRLSEKSVSTVSGLFSAVWATDSGSGV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a575MVSGEEAFRKPASPEGEAGFAEAVSSVPIWLFEGRLSEKSVSTVSGLFSAVWATDSGSGV        10        20        30        40        50        60        70        80        90       100       110       120 m575.pepSMTISTGLYGLKVSGSYTLSVDSMAFQSASARFWVSSSCVSAPDKMPFCAAARLSKSKSM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a575SMTISTGLYGLKVSGSYTLSVDSMAFQSASARFWVSSSCVSAPDKMPFCAAARLSKSKSM        70        80        90       100       110       120       130       140       150       160       170       180 m575.pepRLEGVSVSTSNVCFADNSSSDSPSKASVSFTSFFGAGSGVAGVSTSAKVISMPSSAASSR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a575RLEGVSVSTSNVCFADNSSSDSPSKASVSFTSFFGAGSGVAGVSTSAKVISMPSSAASSR       130       140       150       160       170       180       190       200       210       220       230       240 m575.pepSGSSSGTDSSVRRARLDWARRKSSSRAINAAPPPASSKVYEPPNRPSNSPLSVSSSAETC||||||||||||||||||||||||||||||||||||||||||||    |||||||||||| a575SGSSSGTDSSVRRARLDWARRKSSSRAINAAPPPASSKVYEPPN----SPLSVSSSAETC       190       200       210       220           230       250       260       270       280       290       300 m575.pepSTGSETALPVSSVGVSMAEAAASWGADSAAVSDAAVFAAGTGSGRTAGFSAFASGAATFA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a575STGSETALPVSSVGVSMAEAAASWGADSAAVSDAAVFAAGTGSGRTAGFSAFASGAATFA 240       250       260       270       280       290       310       320       330       340 m575.pepSGFSTGFSTVACLDGSDGMDAVSALGFAVCGLGCSALILFRFGMX||||||||||||||||||||||||||||||||||||||||||||| a575SGFSTGFSTVACLDGSDGMDAVSALGFAVCGLGCSALILFRFGMX 300       310       320       330       340The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1737>:

g576.seq..(partial) 1..atgggcgtgg acatcggacg ctccctgaaa caaatgaagg aacagggcgc 51  ggaaatcgat ttgaaagtct ttaccgatgc catgcaggca gtgtatgacg 101  gcaaagaaat caaaatgacc gaagagcagg cccaggaagt gatgatgaaa 151  ttcctgcagg agcagcaggc taaagccgta gaaaaacaca aggcggatgc 201  gaaggccaac aaagaaaaag gcgaagcctt cctgaaggaa aatgccgccg 251  aagacggcgt gaagaccact gcttccggtc tgcagtacaa aatcaccaaa 301  cagggtgaag gcaaacagcc gacaaaagac gacatcgtta ccgtggaata 351  cgaaggccgc ctgattgacg gtaccgtatt cgacagcagc aaagccaacg 401  gcggcccggc caccttccct ttgagccaag tgattccggg ttggaccgaa 451  ggcgtacggc ttctgaaaga aggcggcgaa gccacgttct acatcccgtc 501  caaccttgcc taccgcgaac agggtgcggg cgaaaaaatc ggtccgaacg 551  ccactttggt atttgacgtg aaactggtca aaatcggcgc acccgaaaac 601  gcgcccgcca agcagccgga tcaagtcgac atcaaaaaag taaattaaThis corresponds to the amino acid sequence <SEQ ID 1738; ORF 576.ng>:

g576.pep..(partial) 1..MGVDIGRSLK QMKEQGAEID LKVFTDAMQA VYDGKEIKMT EEQAQEVMMK 51  FLQEQQAKAV EKHKADAKAN KEKGEAFLKE NAAEDGVKTT ASGLQYKITK 101  QGEGKQPTKD DIVTVEYEGR LIDGTVFDSS KANGGPATFP LSQVIPGWTE 151  GVRLLKEGGE ATFYIPSNLA YREQGAGEKI GPNATLVFDV KLVKIGAPEN 201  APAKQPDQVD IKKVN*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1739>:

m576.seq.. (partial) 1..ATGCAGCAGG CAAGCTATGC GATGGGCGTG GACATCGGAC GCTCCCTGAA 51  GCAAATGAAG GAACAGGGCG CGGAAATCGA TTTGAAAGTC TTTACCGAAG 101  CCATGCAGGC AGTGTATGAC GGCAAAGAAA TCAAAATGAC CGAAGAGCAG 151  GCTCAGGAAG TCATGATGAA ATTCCTTCAG GAACAACAGG CTAAAGCCGT 201  AGAAAAACAC AAGGCGGACG CGAAGGCCAA TAAAGAAAAA GGCGAAGCCT 251  TTCTGAAAGA AAATGCCGCC AAAGACGGCG TGAAGACCAC TGCTTCCGGC 301  CTGCAATACA AAATCACCAA ACAGGGCGAA GGCAAACAGC CGACCAAAGA 351  CGACATCGTT ACCGTGGAAT ACGAAGGCCG CCTGATTGAC GGTACGGTAT 401  TCGACAGCAG CAAAGCCAAC GGCGGCCCGG TCACCTTCCC TTTGAGCCAA 451  GTGATTCCGG GTTGGACCGA AGgCGTACAG CTTCTGAAAG AAGGCGGCGA 501  AGCCACGTTC TACATCCCGT CCAACCTTGC CTACCGCGAA CAGGGTGCGG 551  GCGACAAAAT CGGTCCGAAC GCCACTTTGG TATTTGATGT GAAACTGGTC 601  AAAATCGGCG CACCCGAAAA CGCGCCCGCC AAGCAGCCGG CTCAAGTCGA 651  CATCAAAAAA GTAAATTAAThis corresponds to the amino acid sequence <SEQ ID 1740; ORF 576>:

m576.pep.. (partial) 1..MQQASYAMGV DIGRSLKQMK EQGAEIDLKV FTEAMQAVYD GKEIKMTEEQ 51  AQEVMMKFLQ EQQAKAVEKH KADAKANKEK GEAFLKENAA KDGVKTTASG 101  LQYKITKQGE GKQPTKDDIV TVEYEGRLID GTVFDSSKAN GGPVTFPLSQ 151  VIPGWTEGVQ LLKEGGEATF YIPSNLAYRE QGAGDKIGPN ATLVFDVKLV 201  KIGAPENAPA KQPAQVDIKK VN*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m576/g576 97.2% identity in 215 aa overlap        10        20        30        40        50        60 m576.pepMQQASYAMGVDIGRSLKQMKEQGAEIDLKVFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQ       |||||||||||||||||||||||||:||||||||||||||||||||||||||| g576       MGVDIGRSLKQMKEQGAEIDLKVFTDAMQAVYDGKEIKMTEEQAQEVMMKFLQ               10        20        30        40        50        70        80        90       100       110       120 m576.pepEQQAKAVEKHKADAKANKEKGEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIV||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||| g576EQQAKAVEKHKADAKANKEKGEAFLKENAAEDGVKTTASGLQYKITKQGEGKQPTKDDIV     60        70        80        90       100       110       130       140       150       160       170       180 m576.pepTVEYEGRLIDGTVFDSSKANGGPVTFPLSQVIPGWTEGVQLLKEGGEATFYIPSNLAYRE|||||||||||||||||||||||:|||||||||||||||:|||||||||||||||||||| g576TVEYEGRLIDGTVFDSSKANGGPATFPLSQVIPGWTEGVRLLKEGGEATFYIPSNLAYRE    120       130       140       150       160       170       190       200       210       220 m576.pepQGAGDKIGPNATLVFDVKLVKIGAPENAPAKQPAQVDIKKVNX||||:|||||||||||||||||||||||||||| ||||||||| g576QGAGEKIGPNATLVFDVKLVKIGAPENAPAKQPDQVDIKKVNX    180       190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1741>:

a576.seq 1 ATGAACACCA TTTTCAAAAT CAGCGCACTG ACCCTTTCCG CCGCTTTGGC 51ACTTTCCGCC TGCGGCAAAA AAGAAGCCGC CCCCGCATCT GCATCCGAAC 101CTGCCGCCGC TTCTTCCGCG CAGGGCGACA CCTCTTCGAT CGGCAGCACG 151ATGCAGCAGG CAAGCTATGC GATGGGCGTG GACATCGGAC GCTCCCTGAA 201GCAAATGAAG GAACAGGGCG CGGAAATCGA TTTGAAAGTC TTTACCGAAG 251CCATGCAGGC AGTGTATGAC GGCAAAGAAA TCAAAATGAC CGAAGAGCAG 301GCTCAGGAAG TCATGATGAA ATTCCTTCAG GAACAACAGG CTAAAGCCGT 351AGAAAAACAC AAGGCGGACG CGAAGGCCAA TAAAGAAAAA GGCGAAGCCT 401TTCTGAAAGA AAATGCCGCC AAAGACGGCG TGAAGACCAC TGCTTCCGGC 451CTGCAATACA AAATCACCAA ACAGGGCGAA GGCAAACAGC CGACCAAAGA 501CGACATCGTT ACCGTGGAAT ACGAAGGCCG CCTGATTGAC GGTACGGTAT 551TCGACAGCAG CAAAGCCAAC GGCGGCCCGG TCACCTTCCC TTTGAGCCAA 601GTGATTCTGG GTTGGACCGA AGGCGTACAG CTTCTGAAAG AAGGCGGCGA 651AGCCACGTTC TACATCCCGT CCAACCTTGC CTACCGCGAA CAGGGTGCGG 701GCGACAAAAT CGGCCCGAAC GCCACTTTGG TATTTGATGT GAAACTGGTC 751AAAATCGGCG CACCCGAAAA CGCGCCCGCC AAGCAGCCGG CTCAAGTCGA 801CATCAAAAAA GTAAATTAAThis corresponds to the amino acid sequence <SEQ ID 1742; ORF 576.a>:

a576.pep 1 MNTIFKISAL TLSAALALSA CGKKEAAPAS ASEPAAASSA QGDTSSIGST 51MQQASYAMGV DIGRSLKQMK EQGAEIDLKV FTEAMQAVYD GKEIKMTEEQ 101AQEVMMKFLQ EQQAKAVEKH KADAKANKEK GEAFLKENAA KDGVKTTASG 151LQYKITKQGE GKQPTKDDIV TVEYEGRLID GTVFDSSKAN GGPVTFPLSQ 201VILGWTEGVQ LLKEGGEATF YIPSNLAYRE QGAGDKIGPN ATLVFDVKLV 251KIGAPENAPA KQPAQVDIKK VN* m576/a576 99.5% identity in 222 aa overlap                                      10        20        30 m576.pep                              MQQASYAMGVDIGRSLKQMKEQGAEIDLKV                              |||||||||||||||||||||||||||||| a576CGKKEAAPASASEPAAASSAQGDTSSIGSTMQQASYAMGVDIGRSLKQMKEQGAEIDLKV        30        40        50        60        70        80        40        50        60        70        80        90 m576.pepFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKHKADAKANKEKGEAFLKENAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a576FTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKHKADAKANKEKGEAFLKENAA        90       100       110       120       130       140       100       110       120       130       140       150 m576.pepKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLIDGTVFDSSKANGGPVTFPLSQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a576KDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLIDGTVFDSSKANGGPVTFPLSQ       150       160       170       180       190       200       160       170       180       190       200       210 m576.pepVIPGWTEGVQLLKEGGEATFYIPSNLAYREQGAGDKIGPNATLVFDVKLVKIGAPENAPA ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a576VILGWTEGVQLLKEGGEATFYIPSNLAYREQGAGDKIGPNATLVFDVKLVKIGAPENAPA       210       220       230       240       250       260        220m576.pep KQPAQVDIKKVNX ||||||||||||| a576 KQPAQVDIKKVNX        270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1743>:

g576-1.seq 1 ATGAACACCA TTTTCAAAAT CAGCGCACTG ACCCTTTCCG CCGCTTTGGC 51ACTTTCCGCC TGCGGCAAAA AAGAAGCCGC CCCCGCATCT GCATCCGAAC 101CTGCCGCCGC TTCTGCCGCG CAGGGCGACA CCTCTTCAAT CGGCAGCACG 151ATGCAGCAGG CAAGCTATGC AATGGGCGTG GACATCGGAC GCTCCCTGAA 201ACAAATGAAG GAACAGGGCG CGGAAATCGA TTTGAAAGTC TTTACCGATG 251CCATGCAGGC AGTGTATGAC GGCAAAGAAA TCAAAATGAC CGAAGAGCAG 301GCCCAGGAAG TGATGATGAA ATTCCTGCAG GAGCAGCAGG CTAAAGCCGT 351AGAAAAACAC AAGGCGGATG CGAAGGCCAA CAAAGAAAAA GGCGAAGCCT 401TCCTGAAGGA AAATGCCGCC AAAGACGGCG TGAAGACCAC TGCTTCCGGT 451CTGCAGTACA AAATCACCAA ACAGGGTGAA GGCAAACAGC CGACAAAAGA 501CGACATCGTT ACCGTGGAAT ACGAAGGCCG CCTGATTGAC GGTACCGTAT 551TCGACAGCAG CAAAGCCAAC GGCGGCCCGG CCACCTTCCC TTTGAGCCAA 601GTGATTCCGG GTTGGACCGA AGGCGTACGG CTTCTGAAAG AAGGCGGCGA 651AGCCACGTTC TACATCCCGT CCAACCTTGC CTACCGCGAA CAGGGTGCGG 701GCGAAAAAAT CGGTCCGAAC GCCACTTTGG TATTTGACGT GAAACTGGTC 751AAAATCGGCG CACCCGAAAA CGCGCCCGCC AAGCAGCCGG ATCAAGTCGA 801CATCAAAAAA GTAAATTAAThis corresponds to the amino acid sequence <SEQ ID 1744; ORF 576-1.ng>:

g576-1.pep 1 MNTIFKISAL TLSAALALSA CGKKEAAPAS ASEPAAASAA QGDTSSIGST 51MQQASYAMGV DIGRSLKQMK EQGAEIDLKV FTDAMQAVYD GKEIKMTEEQ 101AQEVMMKFLQ EQQAKAVEKH KADAKANKEK GEAFLKENAA KDGVKTTASG 151LQYKITKQGE GKQPTKDDIV TVEYEGRLID GTVFDSSKAN GGPATFPLSQ 201VIPGWTEGVR LLKEGGEATF YIPSNLAYRE QGAGEKIGPN ATLVFDVKLV 251KIGAPENAPA KQPDQVDIKK VN*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1745>:

m576-1.seq 1 ATGAACACCA TTTTCAAAAT CAGCGCACTG ACCCTTTCCG CCGCTTTGGC 51ACTTTCCGCC TGCGGCAAAA AAGAAGCCGC CCCCGCATCT GCATCCGAAC 101 CTGCCGCCGCTTCTTCCGCG CAGGGCGACA CCTCTTCGAT CGGCAGCACG 151 ATGCAGCAGG CAAGCTATGCGATGGGCGTG GACATCGGAC GCTCCCTGAA 201 GCAAATGAAG GAACAGGGCG CGGAAATCGATTTGAAAGTC TTTACCGAAG 251 CCATGCAGGC AGTGTATGAC GGCAAAGAAA TCAAAATGACCGAAGAGCAG 301 GCTCAGGAAG TCATGATGAA ATTCCTTCAG GAACAACAGG CTAAAGCCGT351 AGAAAAACAC AAGGCGGACG CGAAGGCCAA TAAAGAAAAA GGCGAAGCCT 401TTCTGAAAGA AAATGCCGCC AAAGACGGCG TGAAGACCAC TGCTTCCGGC 451 CTGCAATACAAAATCACCAA ACAGGGCGAA GGCAAACAGC CGACCAAAGA 501 CGACATCGTT ACCGTGGAATACGAAGGCCG CCTGATTGAC GGTACGGTAT 551 TCGACAGCAG CAAAGCCAAC GGCGGCCCGGTCACCTTCCC TTTGAGCCAA 601 GTGATTCCGG GTTGGACCGA AGGCGTACAG CTTCTGAAAGAAGGCGGCGA 651 AGCCACGTTC TACATCCCGT CCAACCTTGC CTACCGCGAA CAGGGTGCGG701 GCGACAAAAT CGGTCCGAAC GCCACTTTGG TATTTGATGT GAAACTGGTC 751AAAATCGGCG CACCCGAAAA CGCGCCCGCC AAGCAGCCGG CTCAAGTCGA 801 CATCAAAAAAGTAAATTAAThis corresponds to the amino acid sequence <SEQ ID 1746; ORF 576-1>:

m576-1.pep 1 MNTIFKISAL TLSAALALSA CGKKEAAPAS ASEPAAASSA QGDTSSIGST 51MQQASYAMGV DIGRSLKQMK EQGAEIDLKV FTEAMQAVYD GKEIKMTEEQ 101 AQEVMMKFLQEQQAKAVEKH KADAKANKEK GEAFLKENAA KDGVKTTASG 151 LQYKITKQGE GKQPTKDDIVTVEYEGRLID GTVFDSSKAN GGPVTFPLSQ 201 VIPGWTEGVQ LLKEGGEATF YIPSNLAYREQGAGDKIGPN ATLVFDVKLV 251 KIGAPENAPA KQPAQVDIKK VN* g576-1/m576-1 97.8%identity in 272 aa overlap        10        20        30        40        50        60 g576-1.pepMNTIFKISALTLSAALALSACGKKEAAPASASEPAAASAAQGDTSSIGSTMQQASYAMGV||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||| m576-1MNTIFKISALTLSAALALSACGKKEAAPASASEPAAASSAQGDTSSIGSTMQQASYAMGV        10        20        30        40        50        60        70        80        90       100       110       120 g576-1.pepDIGRSLKQMKEQGAEIDLKVFTDAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKH||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||| m576-1DIGRSLKQMKEQGAEIDLKVFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKH        70        80        90       100       110       120       130       140       150       160       170       180 g576-1.pepKADAKANKEKGEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLID|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m576-1KADAKANKEKGEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLID       130       140       150       160       170       180       190       200       210       220       230       240 g576-1.pepGTVFDSSKANGGPATFPLSQVIPGWTEGVRLLKEGGEATFYIPSNLAYREQGAGEKIGPN|||||||||||||:|||||||||||||||:||||||||||||||||||||||||:||||| m576-1GTVFDSSKANGGPVTFPLSQVIPGWTEGVQLLKEGGEATFYIPSNLAYREQGAGDKIGPN       190       200       210       220       230       240       250       260       270 g576-1.pepATLVFDVKLVKIGAPENAPAKQPDQVDIKKVNX ||||||||||||||||||||||| |||||||||m576-1 ATLVFDVKLVKIGAPENAPAKQPAQVDIKKVNX        250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1747>:

a576-1.seq 1 ATGAACACCA TTTTCAAAAT CAGCGCACTG ACCCTTTCCG CCGCTTTGGC 51ACTTTCCGCC TGCGGCAAAA AAGAAGCCGC CCCCGCATCT GCATCCGAAC 101 CTGCCGCCGCTTCTTCCGCG CAGGGCGACA CCTCTTCGAT CGGCAGCACG 151 ATGCAGCAGG CAAGCTATGCGATGGGCGTG GACATCGGAC GCTCCCTGAA 201 GCAAATGAAG GAACAGGGCG CGGAAATCGATTTGAAAGTC TTTACCGAAG 251 CCATGCAGGC AGTGTATGAC GGCAAAGAAA TCAAAATGACCGAAGAGCAG 301 GCTCAGGAAG TCATGATGAA ATTCCTTCAG GAACAACAGG CTAAAGCCGT351 AGAAAAACAC AAGGCGGACG CGAAGGCCAA TAAAGAAAAA GGCGAAGCCT 401TTCTGAAAGA AAATGCCGCC AAAGACGGCG TGAAGACCAC TGCTTCCGGC 451 CTGCAATACAAAATCACCAA ACAGGGCGAA GGCAAACAGC CGACCAAAGA 501 CGACATCGTT ACCGTGGAATACGAAGGCCG CCTGATTGAC GGTACGGTAT 551 TCGACAGCAG CAAAGCCAAC GGCGGCCCGGTCACCTTCCC TTTGAGCCAA 601 GTGATTCTGG GTTGGACCGA AGGCGTACAG CTTCTGAAAGAAGGCGGCGA 651 AGCCACGTTC TACATCCCGT CCAACCTTGC CTACCGCGAA CAGGGTGCGG701 GCGACAAAAT CGGCCCGAAC GCCACTTTGG TATTTGATGT GAAACTGGTC 751AAAATCGGCG CACCCGAAAA CGCGCCCGCC AAGCAGCCGG CTCAAGTCGA 801 CATCAAAAAAGTAAATTAAThis corresponds to the amino acid sequence <SEQ ID 1748; ORF 576-1.a>:

a576-1.pep 1 MNTIFKISAL TLSAALALSA CGKKEAAPAS ASEPAAASSA QGDTSSIGST 51MQQASYAMGV DIGRSLKQMK EQGAEIDLKV FTEAMQAVYD GKEIKMTEEQ 101 AQEVMMKFLQEQQAKAVEKH KADAKANKEK GEAFLKENAA KDGVKTTASG 151 LQYKITKQGE GKQPTKDDIVTVEYEGRLID GTVFDSSKAN GGPVTFPLSQ 201 VILGWTEGVQ LLKEGGEATF YIPSNLAYREQGAGDKIGPN ATLVFDVKLV 251 KIGAPENAPA KQPAQVDIKK VN* a576-1/m576-1 99.6%identity in 272 aa overlap        10        20        30        40        50        60 a576-1.pepMNTIFKISALTLSAALALSACGKKEAAPASASEPAAASSAQGDTSSIGSTMQQASYAMGV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m576-1MNTIFKISALTLSAALALSACGKKEAAPASASEPAAASSAQGDTSSIGSTMQQASYAMGV        10        20        30        40        50        60        70        80        90       100       110       120 a576-1.pepDIGRSLKQMKEQGAEIDLKVFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m576-1DIGRSLKQMKEQGAEIDLKVFTEAMQAVYDGKEIKMTEEQAQEVMMKFLQEQQAKAVEKH        70        80        90       100       110       120       130       140       150       160       170       180 a576-1.pepKADAKANKEKGEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLID|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m576-1KADAKANKEKGEAFLKENAAKDGVKTTASGLQYKITKQGEGKQPTKDDIVTVEYEGRLID       130       140       150       160       170       180       190       200       210       220       230       240 a576-1.pepGTVFDSSKANGGPVTFPLSQVILGWTEGVQLLKEGGEATFYIPSNLAYREQGAGDKIGPN|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| m576-1GTVFDSSKANGGPVTFPLSQVIPGWTEGVQLLKEGGEATFYIPSNLAYREQGAGDKIGPN       190       200       210       220       230       240       250       260       270 a576-1.pepATLVFDVKLVKIGAPENAPAKQPAQVDIKKVNX |||||||||||||||||||||||||||||||||m576-1 ATLVFDVKLVKIGAPENAPAKQPAQVDIKKVNX        250       260       270

Expression of ORF 576

The primer described in Table 1 for ORF 576 was used to locate and cloneORF 576. ORF 576 was cloned in pET and pGex vectors and expressed in E.coli as above described. The products of protein expression andpurification were analyzed by SDS-PAGE. FIG. 3A shows the results ofaffinity purification and FIG. 3B shows the expression in E. coli.Purified His-fusion protein was used to immunize mice, whose sera wereused for ELISA (positive result), FACS analysis (FIG. 3C), western blot(FIG. 3D). These experiments confirm that ORF 576 is a surface-exposedprotein and that it is a useful immunogen. The hydrophilicity plots,antigenic index, and amphipatic regions of ORF 576 are provided in FIG.7. The AMPHI program is used to predict putative T-cell epitopes (Gao etal 1989, J. Immunol 143:3007; Roberts et al. 1996, AIDS Res HumanRetroviruses 12:593; Quakyi et al. 1992, Scand J Immunol Suppl 11:9).The nucleic acid sequence of ORF 576 and the amino acid sequence encodedthereby is provided in Example 1.

The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1749>:

g577.seq.. 1 atggaaagga gcggtgtatt tggtaaaatt gtcggcaatc gcatactccg 51tatgccgtcc gaacacgctg ccgcattcta tccgaaaccg tgcaaatcgt 101 ttaaactaacgcaatcttgg ttcagagtgc gaagctgtcc gtgcggcgtt 151 tttatttacg gagcaaacatgaaacttatc tataccgtca tcaaaatcat 201 tatcctgctg ctcttcctgc tgcttgccgtcattaatatg gatgccgtta 251 ccttttccta tcttccgggg cagagtgtca atctgccgctgattgtcgta 301 ttgttcggcg cgtttgtcgt cggcatcgtg ttcggaatgt ttgccctgtt351 cgggcggctg ctgtccttgc gcggcgaaaa cagccgcctg cgtgcggaag 401tgaagaaaag tgcgcgcttg agcggacaga aattgactgc accgccgata 451 caaaatgctgccgaatctgc caaacagcct taaThis corresponds to the amino acid sequence <SEQ ID 1750; ORF 577.ng>:

g577.pep 1 MERSGVFGKI VGNRILRMPS EHAAAFYPKP CKSFKLTQSW FRVRSCPCGV 51FIYGANMKLI YTVIKIIILL LFLLLAVINM DAVTFSYLPG QSVNLPLIVV 101LFGAFVVGIV FGMFALFGRL LSLRGENSRL RAEVKKSARL SGQKLTAPPI 151 QNAAESAKQP *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1751>:

m577.seq.. 1 ATGGAAAGGA ACGGTGTATT TGGTAAAATT GTCGGCAATC GCATACTCCG 51TATGTCGTCC GAACACGCTG CCGCATCCTA TCCGAAACCG TGCAAATCGT 101 TTAAACTAGCGCAATCTTGG TTCAGAGTGC GAAGCTGTCT GGGCGGCGTT 151 TTTATTTACG GAGCAAACATGAAACTTATC TATACCGTCA TCAAAATCAT 201 TATCCTGCTG CTCTTCCTGC TGCTTGCCGTCATTAATACG GATGCCGTTA 251 CCTTTTCCTA CCTGCCGGGG CAAAAATTCG ATTTGCCGCTGATTGTCGTA 301 TTGTTCGGCG CATTTGTAGT CGGTATTATT TTTGGAATGT TTGCCTTGTT351 CGGACGGTTG TTGTCGTTAC GTGGCGAGAA CGGCAGGTTG CGTGCCGAAG 401TAAAGAAAAA TGCGCGTTTG ACGGGGAAGG AGCTGACCGC ACCACCGGCG 451 CAAAATGCGCCCGAATCTAC CAAACAGCCT TAAThis corresponds to the amino acid sequence <SEQ ID 1752; ORF 577>:

m577.pep.. 1 MERNGVFGKI VGNRILRMSS EHAAASYPKP CKSFKLAQSW FRVRSCLGGV 51FIYGANMKLI YTVIKIIILL LFLLLAVINT DAVTFSYLPG QKFDLPLIVV 101LFGAFVVGII FGMFALFGRL LSLRGENGRL RAEVKKNARL TGKELTAPPA 151 QNAPESTKQP *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m577/g577 88.1% identity in 160 aa overlap        10        20        30        40        50        60 m577.pepMERNGVFGKIVGNRILRMSSEHAAASYPKPCKSFKLAQSWFRVRSCLGGVFIYGANMKLI|||:|||||||||||||| |||||| ||||||||||:|||||||||  |||||||||||| g577MERSGVFGKIVGNRILRMPSEHAAAFYPKPCKSFKLIQSWFRVRSCPCGVFIYGANMKLI        10        20        30        40        50        60        70        80        90       100       110       120 m577.pepYTVIKIIILLLFLLLAVINTDAVTFSYLPGQKFDLPLIVVLFGAFVVGIIFGMFALFGRL||||||||||||||||||| |||||||||||: :|||||||||||||||:|||||||||| g577YTVIKIIILLLFLLLAVINMDAVTFSYLPGQSVNLPLIVVLFGAFVVGIVFGMFALFGRL        70        80        90       100       110       120       130       140       150       160 m577.pepLSLRGENGRLRAEVKKNARLTGKELTAPPAQNAPESTKQPX|||||||:||||||||:|||:|::||||| ||| ||:|||| g577LSLRGENSRLRAEVKKSARLSGQKLTAPPIQNAAESAKQPX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1753>:

a577.seq 1 ATGGAAAGGA ACGGTGTATT TGGTAAAATT GTCGGCAATC GCATACTCCG 51TATGTCGTCC GAACACGCTG CCGCATCCTA TCCGAAACCG TGCAAATCGT 101 TTAAACTAGCGCAATCTTGG TTCAGAGTGC GAAGCTGTCC GGGCGGCGTT 151 TTTATTTACG GAGCAAACATGAAACTTATC TATACCGTCA TCAAAATCAT 201 TATCCTGCTG CTCTTCCTGC TGCTTGCTGTCATTAATACG GATGCCGTTA 251 CCTTTTCCTA CCTGCCGGGG CAAAAATTCG ATTTGCCGCTGATTGTCGTA 301 TTGTTCGGCG CGTTTGTCGT CGGCATCGTG TTCGGAATGT TTGCCTTGTT351 CGGACGGTTG TTGTCGTTAC GTGGCGAGAA CGGCAGGTTG CGTGCCGAAG 401TAAAGAAAAA TGCGCGTTTG ACGGGGAAGG AGCTGACCGC ACCACCGGCG 451 CAAAATGCGCCCGAATCTGC CAAACAGCCT TGAThis corresponds to the amino acid sequence <SEQ ID 1754; ORF 577.a>:

a577.pep 1 MERNGVFGKI VGNRILRMSS EHAAASYPKP CKSFKLAQSW FRVRSCPGGV 51FIYGANMKLI YTVIKIIILL LFLLLAVINT DAVTFSYLPG QKFDLPLIVV 101LFGAFVVGIV FGMFALFGRL LSLRGENGRL RAEVKKNARL TGKELTAPPA 151 QNAPESAKQP *m577/a577 98.1% identity in 160 aa overlap        10        20        30        40        50        60 m577.pepMERNGVFGKIVGNRILRMSSEHAAASYPKPCKSFKLAQSWFRVRSCLGGVFIYGANMKLI|||||||||||||||||||||||||||||||||||||||||||||| ||||||||||||| a577MERNGVFGKIVGNRILRMSSEHAAASYPKPCKSFKLAQSWFRVRSCPGGVFIYGANMKLI        10        20        30        40        50        60        70        80        90       100       110       120 m577.pepYTVIKIIILLLFLLLAVINTDAVTFSYLPGQKFDLPLIVVLFGAFVVGIIFGMFALFGRL|||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||| a577YTVIKIIILLLFLLLAVINTDAVIFSYLPGQKFDLPLIVVLFGAFVVGIVFGMFALFGRL        70        80        90       100       110       120       130       140       150       160 m577.pepLSLRGENGRLRAEVKKNARLTGKELTAPPAQNAPESTKQPX||||||||||||||||||||||||||||||||||||:|||| a577LSLRGENGRLRAEVKKNARLTGKELTAPPAQNAPESAKQPX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1755>:

g578.seq.. 1 atgggaaagc tcgacatcgg gatattgttt gccgatttct tcaaagattt 51cgcgccacag ttcggtggtt tccaaaacgt tggctttgcc tacggagcag 101 acttttttgctgcgtttttg ggcggattgg aaggccacgt gggcgatgcg 151 gcggatttcg ctttcgctgtatttcatggt gttgtagcct tcgtgttcgc 201 cgttttccaa aacacggatg ccgcgcggttcgccgaaata aatatcgccg 251 gtaagttcgc gcacaatcaa aatatccaaa ccggcaacgatttcaggctt 301 gagcgtggag gcgttggcta aThis corresponds to the amino acid sequence <SEQ ID 1756; ORF 578.ng>:

g578.pep 1 MGKLDIGILF ADFFKDFAPQ FGGFQNVGFA YGADFFAAFL GGLEGHVGDA 51ADFAFAVFHG VVAFVFAVFQ NTDAARFAEI NIAGKFAHNQ NIQTGNDFRL 101 ERGGVG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1757>:

m578.seq.. 1 ATGGGAAAGC TCGACATCAG GGTACTCTTT GCCGATTTCT TCAAAGATTT 51CGCGCCACAA TTCGGTGGTT TCCAAAACGT TGGCTTTGCC TACGGAACAG 101 ACTTTTTTGCTGCGTTTTTG GGCGGATTGG AAGGCAACAT GGGCAATACG 151 GCGGATTTCG CTTTCGCTGTATTTCATGGT GTTGTAGCCT TCGCGTTCGC 201 CGTTTTCCAG AACGCGGATG CCGCGCGGTTCGCCGAAATA GATGTCGCCG 251 GTGAGTTCGC GCACAATCAA AATATCCAAA CCGGCAACGATTTCAGGCTTThis corresponds to the amino acid sequence <SEQ ID 1758; ORF 578>:

m578.pep.. 1 MGKLDIRVLF ADFFKDFAPQ FGGFQNVGFA YGTDFFAAFL GGLEGNMGNT 51ADFAFAVFHG VVAFAFAVFQ NADAARFAEI DVAGEFAHNQ NIQTGNDFRL 101 QRGGVG*m578/g578 87.7% identity in 106 aa overlap        10        20        30        40        50        60 m578.pepMGKLDIRVLFADFFKDFAPQFGGFQNVGFAYGTDFFAAFLGGLEGNMGNTADFAFAVFHG|||||| :||||||||||||||||||||||||:||||||||||||::|::|||||||||| g578MGKLDIGILFADFFKDFAPQFGGFQNVGFAYGADFFAAFLGGLEGHVGDAADFAFAVFHG        10        20        30        40        50        60        70        80        90       100 m578.pepVVAFAFAVFQNADAARFAEIDVAGEFAHNQNIQTGNDFRLQRGGVGX||||:||||||:||||||||::||:|||||||||||||||:|||||| g578VVAFVFAVFQNTDAARFAEINIAGKFAHNQNIQTGNDFRLERGGVGX        70        80        90       100The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1759>:

a578.seq 1 ATGGGAAAGC TCGACATCAG GGTATTCTTT GCCGATTTCT TCAAAGATTT 51CGCGCCACAA TTCGGTGGTT TCCAAAACGT TGGCTTTGCC TACGGAGCAG 101ACTTTTTTGC TGCGTTTTTG GGCGGATTGG AAGGCGACGT GGGCAATACG 151GCGGATTTCG CTTTCGCTGT ATTTCATGGT GTTGTAGCCT TCGCGTTCGC 201CGTTTTCCAG AACACGGATG CCGCGCGGTT CGCCGAAATA AATATCGCCG 251GTGAGTTCGC GCACAATCAA AATATCCAAA CCCGCAACGA TTTCAGACTT 301GAGCGTGGAG GCGTTGGCTA GThis corresponds to the amino acid sequence <SEQ ID 1760; ORF 578.a>:

a578.pep 1 MGKLDIRVFF ADFFKDFAPQ FGGFQNVGFA YGADFFAAFL GGLEGDVGNT 51ADFAFAVFHG VVAFAFAVFQ NTDAARFAEI NIAGEFAHNQ NIQTRNDFRL 101 ERGGVG*m578/a578 91.5% identity in 106 aa overlap        10        20        30        40        50        60 m578.pepMGKLDIRVLFADFFKDFAPQFGGFQNVGFAYGTDFFAAFLGGLEGNMGNTADFAFAVFHG||||||||:|||||||||||||||||||||||:||||||||||||::||||||||||||| a578MGKLDIRVFFADFFKDFAPQFGGFQNVGFAYGADFFAAFLGGLEGDVGNTADFAFAVFHG        10        20        30        40        50        60        70        80        90       100 m578.pepVVAFAFAVFQNADAARFAEIDVAGEFAHNQNIQTGNDFRLQRGGVGX|||||||||||:||||||||::|||||||||||| |||||:|||||| a578VVAFAFAVFQNTDAARFAEINIAGEFAHNQNIQTRNDFRLERGGVGX        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1761>:

g579.seq.. 1 ATGAGGGCGG CGATGACGCG CGCGCAGGTC GATGCCACGC TGATTAGTTT 51TTTGTGTAAT GTTGCCAATA TCGGCTTATT GATTTTGGTG ATTATTGCCG 101CATTGGGACG GTTGGGCGTT TCCACAACAT CCGTAACCGC CTTAATCGGC 151GGCGCGGGTT TGGCGGTGGC GTTGTCCTTA AAAGACCAGC TGTCCAATTT 201TGCCGCCGGC GCGCTGATTA TCCTGTTCCG CCCGTTCAAA GTCGGCGACT 251TTATCCGTGT CGGCGGTTTT GAAGGATATG TCCGGGAAAT CAAAATGGTG 301CAGACTTCTT TGCGGACGAC CGACAACGAA GAAGTCGTGC TGCCCAACAG 351CGTGGTGATG GGCAACAGCA TCGTCAACCG TTCCAGCCTG CCGCTTTGCC 401GCGCCCAAGT GATAGTCGGC GTCGATTACA ACTGCGATTT GAAAGTGGCG 451AAAGAGGCGG TGTTGAAAGC CGCCGCCGAA CACCCCTTGA GCGTTCAAAA 501CGAAGAGCGG CAGCCCGCCG CCTACATCAC CGCCTTGGGC GACAATGCCA 551TCGAAATCAC ATTATGGGCT TGGGCAAACG AAGCAGACCG CTGGACGCTG 601CAATGCGACT TGAACGAACA AGTGGTCGAA AACCTCCGCA AAGTCAATAT 651CAACATCCCG TTCCCGCAAC GCGACATACA CATCATCAAT TCTTAAThis corresponds to the amino acid sequence <SEQ ID 1762; ORF 579.ng>:

g579.pep.. 1 MRAAMTRAQV DATLISFLCN VANIGLLILV IIAALGRLGV STTSVTALIG 51GAGLAVALSL KDQLSNFAAG ALIILFRPFK VGDFIRVGGF EGYVREIKMV 101QTSLRTTDNE EVVLPNSVVM GNSIVNRSSL PLCRAQVIVG VDYNCDLKVA 151KEAVLKAAAE HPLSVQNEER QPAAYITALG DNAIEITLWA WANEADRWTL 201QCDLNEQVVE NLRKVNINIP FPQRDIHIIN S*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1763>:

m579.seq.. 1 ATGAGGGCGG CGATGACGCG CGCGCAGGTC GATGCCACGC TGATTAGTTT 51TTTGTGTAAT GTTGCCAATA TCGGCTTATT GATTTTGGTG ATTATTGCCG 101CATTGGGCAG ATTGGGCGTT TCCACAACAT CCGTAACCGC CTTAATCGGC 151GGCGCGGGTT TGGCGGTGGC GTTGTCCCTG AAAGACCAGC TGTCCAATTT 201TGCCGCCGGC GCACTGATTA TCCTGTTCCG CCCGTTCAAA GTCGGCGATT 251TTATCCGCGT CGGCGGTTTT GAAGGATATG TCCGAGAGAT TAAAATGGTG 301CAGACTTCTT TGCGGACGAC CGACAACGAA GAAGTCGTGC TGCCCAACAG 351CGTGGTGATG GGCAACAGCA TCGTCAACCG TTCCACACTG CCGCTGTGCC 401GCGCCCAAGT GATAGTCGGC GTCGATTACA ACTGCGATTT GAAAGTGGCG 451AAAGAGGCGG TGTTGAAAGC CGCCGTCGAA CACCCCTTGA GCGTTCAAAA 501CGAAGAGCGG CAGGCTGCCG CCTACATCAC CGCCTTGGGC GACAATGCCA 551TCGAAATCAC ATTATGGGCT TGGGCAAACG AAGCAGACCG CTGGACGCTG 601CAATGCGACT TGAACGAACA AGTGGTCGAA AACCTCCGCA AAGTCAATAT 651CAACATCCCG TTCCCGCAAC GCGACATACA CATCATCAAT TCTTAAThis corresponds to the amino acid sequence <SEQ ID 1764; ORF 579>:

m579.pep.. 1 MRAAMTRAQV DATLISFLCN VANIGLLILV IIAALGRLGV STTSVTALIG 51GAGLAVALSL KDQLSNFAAG ALIILFRPFK VGDFIRVGGF EGYVREIKMV 101QTSLRTTDNE EVVLPNSVVM GNSIVNRSTL PLCRAQVIVG VDYNCDLKVA 151KEAVLKAAVE HPLSVQNEER QAAAYITALG DNAIEITLWA WANEADRWTL 201QCDLNEQVVE NLRKVNINIP FPQRDIHIIN S*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m579/g579 98.7% identity in 231 aa overlap        10        20        30        40        50        60 m579.pepMRAAMTRAQVDATLISFLCNVANIGLLILVIIAALGRLGVSTTSVTALIGGAGLAVALSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g579MRAAMTRAQVDATLISFLCNVANIGLLILVIIAALGRLGVSTTSVTALIGGAGLAVALSL        10        20        30        40        50        60        70        80        90       100       110       120 m579.pepKDQLSNFAAGALIILFRPFKVGDFIRVGGFEGYVREIKMVQTSLRTTDNEEVVLPNSVVM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g579KDQLSNFAAGALIILFRPFKVGDFIRVGGFEGYVREIKMVQTSLRTTDNEEVVLPNSVVM        70        80        90       100       110       120       130       140       150       160       170       180 m579.pepGNSIVNRSTLPLCRAQVIVGVDYNCDLKVAKEAVLKAAVEHPLSVQNEERQAAAYITALG||||||||:|||||||||||||||||||||||||||||:|||||||||||| |||||||| g579GNSIVNRSSLPLCRAQVIVGVDYNCDLKVAKEAVLKAAAEHPLSVQNEERQPAAYITALG       130       140       150       160       170       180       190       200       210       220       230 m579.pepDNAIEITLWAWANEADRWTLQCDLNEQVVENLRKVNINIPFPQRDIHIINSX|||||||||||||||||||||||||||||||||||||||||||||||||||| g579DNAIEITLWAWANEADRWTLQCDLNEQVVENLRKVNINIPFPQRDIHIINSX       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1765>:

a579.seq 1 ATGAGGGCGG CGATGACGCG CGCGCAGGTC GATGCCACGC TGATTAGTTT 51TTTGTGTAAT GTTGCCAATA TCGGCTTATT GATTTTGGTG ATTATTGCCG 101CATTGGGCAG ATTGGGCGTT TCCACAACAT CCGTAACCGC CTTAATCGGC 151GGCGCGGGTT TGGCGGTGGC GTTGTCCTTG AAAGACCAGC TGTCCAATTT 201TGCCGCCGGC GCGCTGATTA TCCTGTTCCG CCCGTTCAAA GTCGGCGATT 251TTATCCGCGT CGGCGGTTTT GAAGGATATG TCCGAGAGAT TAAAATGGTG 301CAGACTTCTT TGCGGACGAC CGACAACGAA GAAGTCGTGC TGCCCAACAG 351CGTGGTGATG GGCAACAGCA TCGTCAACCG TTCCACACTG CCGCTGTGCC 401GCGCCCAAGT GATAGTCGGC GTCGATTACA ACTGCGATTT GAAAGTGGCG 451AAAGAGGCGG TGTTGAAAGC CGCCGTCGAA CACCCCTTGA GCGTTCAAAA 501CGAAGAGCGG CAGGCCGCCG CCTACATCAC CGCCTTGGGC GACAATGCCA 551TCGAAATCAC ATTATGGGCT TGGGCAAACG AAGCAGACCG CTGGACGCTG 601CAATGCGACT TGAACGAACA AGTGGTCGAA AACCTCCGCA AAGTCAATAT 651CAACATCCCG TTCCCGCAAC GCGACATACA CATCATCAAT TCTTAAThis corresponds to the amino acid sequence <SEQ ID 1766; ORF 579.a>:

a579.pep 1 MRAAMTRAQV DATLISFLCN VANIGLLILV IIAALGRLGV STTSVTALIG 51GAGLAVALSL KDQLSNFAAG ALIILFRPFK VGDFIRVGGF EGYVREIKMV 101QTSLRTTDNE EVVLPNSVVM GNSIVNRSTL PLCRAQVIVG VDYNCDLKVA 151KEAVLKAAVE HPLSVQNEER QAAAYITALG DNAIEITLWA WANEADRWTL 201QCDLNEQVVE NLRKVNINIP FPQRDIHIIN S* m579/a579100.0% identity in 231 aa overlap        10        20        30        40        50        60 m579.pepMRAAMTRAQVDATLISFLCNVANIGLLILVIIAALGRLGVSTTSVTALIGGAGLAVALSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a579MRAAMTRAQVDATLISFLCNVANIGLLILVIIAALGRLGVSTTSVTALIGGAGLAVALSL        10        20        30        40        50        60        70        80        90       100       110       120 m579.pepKDQLSNFAAGALIILFRPFKVGDFIRVGGFEGYVREIKMVQTSLRTTDNEEVVLPNSVVM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a579KDQLSNFAAGALIILFRPFKVGDFIRVGGFEGYVREIKMVQTSLRTIDNEEVVLPNSVVM        70        80        90       100       110       120       130       140       150       160       170       180 m579.pepGNSIVNRSTLPLCRAQVIVGVDYNCDLKVAKEAVLKAAVEHPLSVQNEERQAAAYITALG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a579GNSIVNRSTLPLCRAQVIVGVDYNCDLKVAKEAVLKAAVEHPLSVQNEERQAAAYITALG       130       140       150       160       170       180       190       200       210       220       230 m579.pepDNAIEITLWAWANEADRWTLQCDLNEQVVENLRKVNINIPFPQRDIHIINSX|||||||||||||||||||||||||||||||||||||||||||||||||||| a579DNAIEITLWAWANEADRWTLQCDLNEQVVENLRKVNINIPFPQRDIHIINSX       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1767>:

g579-1.seq 1 ATGGACTTCA AACAATTTGA TTTTTTACAC CTGATCAGTG TTTCCGGTTG 51GGGGCATCTG GCTGAAAAGG CGTGGGCGTT CGGGCTGAAC CTTGCCGCCG 101CGCTGCTTAT TTTCTTGGTC GGGAAATGGG CGGCGAAACG CATTGTCGCC 151GTAATGAGGG CGGCGATGAC GCGCGCGCAG GTCGATGCCA CGCTGATTAG 201TTTTTTGTGT AATGTTGCCA ATATCGGCTT ATTGATTTTG GTGATTATTG 251CCGCATTGGG ACGGTTGGGC GTTTCCACAA CATCCGTAAC CGCCTTAATC 301GGCGGCGCGG GTTTGGCGGT GGCGTTGTCC TTAAAAGACC AGCTGTCCAA 351TTTTGCCGCC GGCGCGCTGA TTATCCTGTT CCGCCCGTTC AAAGTCGGCG 401ACTTTATCCG TGTCGGCGGT TTTGAAGGAT ATGTCCGGGA AATCAAAATG 451GTGCAGACTT CTTTGCGGAC GACCGACAAC GAAGAAGTCG TGCTGCCCAA 501CAGCGTGGTG ATGGGCAACA GCATCGTCAA CCGTTCCAGC CTGCCGCTTT 551GCCGCGCCCA AGTGATAGTC GGCGTCGATT ACAACTGCGA TTTGAAAGTG 601GCGAAAGAGG CGGTGTTGAA AGCCGCCGCC GAACACCCCT TGAGCGTTCA 651AAACGAAGAG CGGCAGCCCG CCGCCTACAT CACCGCCTTG GGCGACAATG 701CCATCGAAAT CACATTATGG GCTTGGGCAA ACGAAGCAGA CCGCTGGACG 751CTGCAATGCG ACTTGAACGA ACAAGTGGTC GAAAACCTCC GCAAAGTCAA 801TATCAACATC CCGTTCCCGC AACGCGACAT ACACATCATC AATTCTTAAThis corresponds to the amino acid sequence <SEQ ID 1768; ORF 008.ng>:

g579-1.pep 1 MDFKQFDFLH LISVSGWGHL AEKAWAFGLN LAAALLIFLV GKWAAKRIVA 51VMRAAMTRAQ VDATLISFLC NVANIGLLIL VIIAALGRLG VSTTSVTALI 101GGAGLAVALS LKDQLSNFAA GALIILFRPF KVGDFIRVGG FEGYVREIKM 151VQTSLRTTDN EEVVLPNSVV MGNSIVNRSS LPLCRAQVIV GVDYNCDLKV 201AKEAVLKAAA EHPLSVQNEE RQPAAYITAL GDNAIEITLW AWANEADRWT 251LQCDLNEQVV ENLRKVNINI PFPQRDIHII NS*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1769>:

m579-1.seq 1 ATGGACTTCA AACAATTTGA TTTTTTACAC CTGATCAGTG TTTCCGGTTG 51GGAGCATCTG GCTGAAAAGG CGTGGGCGTT CGGGCTGAAC CTTGCCGCCG 101CGCTGCTTAT TTTTTTGGTC GGAAAATGGG CGGCGAAACG CATTGTCGCT 151GTGATGAGGG CGGCGATGAC GCGCGCGCAG GTCGATGCCA CGCTGATTAG 201TTTTTTGTGT AATGTTGCCA ATATCGGCTT ATTGATTTTG GTGATTATTG 251CCGCATTGGG CAGATTGGGC GTTTCCACAA CATCCGTAAC CGCCTTAATC 301GGCGGCGCGG GTTTGGCGGT GGCGTTGTCC CTGAAAGACC AGCTGTCCAA 351TTTTGCCGCC GGCGCACTGA TTATCCTGTT CCGCCCGTTC AAAGTCGGCG 401ATTTTATCCG CGTCGGCGGT TTTGAAGGAT ATGTCCGAGA GATTAAAATG 451GTGCAGACTT CTTTGCGGAC GACCGACAAC GAAGAAGTCG TGCTGCCCAA 501CAGCGTGGTG ATGGGCAACA GCATCGTCAA CCGTTCCACA CTGCCGCTGT 551GCCGCGCCCA AGTGATAGTC GGCGTCGATT ACAACTGCGA TTTGAAAGTG 601GCGAAAGAGG CGGTGTTGAA AGCCGCCGTC GAACACCCCT TGAGCGTTCA 651AAACGAAGAG CGGCAGGCTG CCGCCTACAT CACCGCCTTG GGCGACAATG 701CCATCGAAAT CACATTATGG GCTTGGGCAA ACGAAGCAGA CCGCTGGACG 751CTGCAATGCG ACTTGAACGA ACAAGTGGTC GAAAACCTCC GCAAAGTCAA 801TATCAACATC CCGTTCCCGC AACGCGACAT ACACATCATC AATTCTTAAThis corresponds to the amino acid sequence <SEQ ID 1770; ORF 579-1>:

m579-1.pep 1 MDFKQFDFLH LISVSGWEHL AEKAWAFGLN LAAALLIFLV GKWAAKRIVA 51VMRAAMTRAQ VDATLISFLC NVANIGLLIL VIIAALGRLG VSTTSVTALI 101GGAGLAVALS LKDQLSNFAA GALIILFRPF KVGDFIRVGG FEGYVREIKM 151VQTSLRTTDN EEVVLPNSVV MGNSIVNRST LPLCRAQVIV GVDYNCDLKV 201AKEAVLKAAV EHPLSVQNEE RQAAAYITAL GDNAIEITLW AWANEADRWT 251LQCDLNEQVV ENLRKVNINI PFPQRDIHII NS* m579-1/g579-198.6% identity in 282 aa overlap        10        20        30        40        50        60 m579-1.pepMDFKQFDFLHLISVSGWEHLAEKAWAFGLNLAAALLIFLVGKWAAKRIVAVMRAAMTRAQ||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||| g579-1MDFKQFDFLHLISVSGWGHLAEKAWAFGLNLAAALLIFLVGKWAAKRIVAVMRAAMTRAQ        10        20        30        40        50        60        70        80        90       100       110       120 m579-1.pepVDATLISFLCNVANIGLLILVIIAALGRLGVSTTSVTALIGGAGLAVALSLKDQLSNFAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g579-1VDATLISFLCNVANIGLLILVIIAALGRLGVSTTSVTALIGGAGLAVALSLKDQLSNFAA        70        80        90       100       110       120       130       140       150       160       170       180 m579-1.pepGALIILFRPFKVGDFIRVGGFEGYVREIKMVQTSLRTTDNEEVVLPNSVVMGNSIVNRST|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: g579-1GALIILFRPFKVGDFIRVGGFEGYVREIKMVQTSLRTTDNEEVVLPNSVVMGNSIVNRSS       130       140       150       160       170       180       190       200       210       220       230       240 m579-1.pepLPLCRAQVIVGVDYNCDLKVAKEAVLKAAVEHPLSVQNEERQAAAYITALGDNAIEITLW|||||||||||||||||||||||||||||:|||||||||||| ||||||||||||||||| g579-1LPLCRAQVIVGVDYNCDLKVAKEAVLKAAAEHPLSVQNEERQPAAYITALGDNAIEITLW       190       200       210       220       230       240       250       260       270       280 m579-1.pepAWANEADRWTLQCDLNEQVVENLRKVNINIPFPQRDIHIINSX||||||||||||||||||||||||||||||||||||||||||| g579-1AWANEADRWTLQCDLNEQVVENLRKVNINIPFPQRDIHIINSX       250       260       270       280The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1771>:

a579-1.seq 1 ATGGACTTCA AACAATTTGA TTTTTTACAC CTGATAAGTG CTTCCGGCTG 51GGAGCATCTG GCTGAAAAGG CGTGGGCGTT CGGGCTGAAC CTTGCCGCCG 101CGCTGCTTAT TTTTTTGGTC GGAAAATGGG CGGCGAAACG CATTGTCGCC 151GTGATGAGGG CGGCGATGAC GCGCGCGCAG GTCGATGCCA CGCTGATTAG 201TTTTTTGTGT AATGTTGCCA ATATCGGCTT ATTGATTTTG GTGATTATTG 251CCGCATTGGG CAGATTGGGC GTTTCCACAA CATCCGTAAC CGCCTTAATC 301GGCGGCGCGG GTTTGGCGGT GGCGTTGTCC TTGAAAGACC AGCTGTCCAA 351TTTTGCCGCC GGCGCGCTGA TTATCCTGTT CCGCCCGTTC AAAGTCGGCG 401ATTTTATCCG CGTCGGCGGT TTTGAAGGAT ATGTCCGAGA GATTAAAATG 451GTGCAGACTT CTTTGCGGAC GACCGACAAC GAAGAAGTCG TGCTGCCCAA 501CAGCGTGGTG ATGGGCAACA GCATCGTCAA CCGTTCCACA CTGCCGCTGT 551GCCGCGCCCA AGTGATAGTC GGCGTCGATT ACAACTGCGA TTTGAAAGTG 601GCGAAAGAGG CGGTGTTGAA AGCCGCCGTC GAACACCCCT TGAGCGTTCA 651AAACGAAGAG CGGCAGGCCG CCGCCTACAT CACCGCCTTG GGCGACAATG 701CCATCGAAAT CACATTATGG GCTTGGGCAA ACGAAGCAGA CCGCTGGACG 751CTGCAATGCG ACTTGAACGA ACAAGTGGTC GAAAACCTCC GCAAAGTCAA 801TATCAACATC CCGTTCCCGC AACGCGACAT ACACATCATC AATTCTTAAThis corresponds to the amino acid sequence <SEQ ID 1772; ORF 579-1.a>:

a579-1.pep 1 MDFKQFDFLH LISASGWEHL AEKAWAFGLN LAAALLIFLV GKWAAKRIVA 51VMRAAMTRAQ VDATLISFLC NVANIGLLIL VIIAALGRLG VSTTSVTALI 101GGAGLAVALS LKDQLSNFAA GALIILFRPF KVGDFIRVGG FEGYVREIKM 151VQTSLRTTDN EEVVLPNSVV MGNSIVNRST LPLCRAQVIV GVDYNCDLKV 201AKEAVLKAAV EHPLSVQNEE RQAAAYITAL GDNAIEITLW AWANEADRWT 251LQCDLNEQVV ENLRKVNINI PFPQRDIHII NS* a579-1/m579-199.6% identity in 282 aa overlap        10        20        30        40        50        60 a579-1.pepMDFKQFDFLHLISASGWEHLAEKAWAFGLNLAAALLIFLVGKWAAKRIVAVMRAAMTRAQ|||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||| m579-1MDFKQFDFLHLISVSGWEHLAEKAWAFGLNLAAALLIFLVGKWAAKRIVAVMRAAMTRAQ        10        20        30        40        50        60        70        80        90       100       110       120 a579-1.pepVDATLISFLCNVANIGLLILVIIAALGRLGVSTTSVTALIGGAGLAVALSLKDQLSNFAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m579-1VDATLISFLCNVANIGLLILVIIAALGRLGVSTTSVTALIGGAGLAVALSLKDQLSNFAA        70        80        90       100       110       120       130       140       150       160       170       180 a579-1.pepGALIILFRPFKVGDFIRVGGFEGYVREIKMVQTSLRTTDNEEVVLPNSVVMGNSIVNRST|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m579-1GALIILFRPFKVGDFIRVGGFEGYVREIKMVQTSLRTTDNEEVVLPNSVVMGNSIVNRST       130       140       150       160       170       180       190       200       210       220       230       240 a579-1.pepLPLCRAQVIVGVDYNCDLKVAKEAVLKAAVEHPLSVQNEERQAAAYITALGDNAIEITLW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m579-1LPLCRAQVIVGVDYNCDLKVAKEAVLKAAVEHPLSVQNEERQAAAYITALGDNAIEITLW       190       200       210       220       230       240       250       260       270       280 a579-1.pepAWANEADRWTLQCDLNEQVVENLRKVNINIPFPQRDIHIINSX||||||||||||||||||||||||||||||||||||||||||| m579-1AWANEADRWTLQCDLNEQVVENLRKVNINIPFPQRDIHIINSX       250       260       270       280The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1773>:

g580.seq 1 atggattcgc ccaaggtcgg gtgcgggtgg atggttttgc cgatgtctgc 51cgcgtcgcag cccatttcga tggcaaggca gacttcgccg atcatgtcgc 101 caccgttcggaccgacaatg ccgccgccga tgatgcggcc ggtttcggca 151 tcgaaaatca gcttggtaaagccgttgtcg caaccgttgg caatcgcacg 201 accggaagcc gcccatggga agttggctttggtaattttg cggcctgatg 251 ctttggcaga caattcggtt tcaccgaccc atgccacttcgggggaagtg 301 tagThis corresponds to the amino acid sequence <SEQ ID 1774; ORF 580.ng>:

g580.pep.. 1 MDSPKVGCGW MVLPMSAASQ PISMARQTSP IMSPPFGPTM PPPMMRPVSA 51SKISLVKPLS QPLAIARPEA AHGKLALVIL RPDALADNSV SPTHATSGEV 101 *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1775>:

m580.seq.. 1 ATGGATTCGC CCAAGGTCGG GTGCGGGTGG ATGGTTTTGC CGATGTCTGC 51CGCGTCGCAG CCCATTTCGA TGGCAAGGCA GACTTCGCCG ATCATATCGC 101 CACCGTTCGGACCGACAATG CCGCCGCCGA TGATGCGGCC GGTTTCGGCA 151 TCAAAAATCA GCTTGGTAAAGCCGTTGTCG CAACCGTTGG CAATCGCACG 201 GCCGGAAGCC GCCCACGGGA AGTTGGCTTTGGTGATTTTG CGGCCGGAGG 251 CTTTGGCGGA CAGTTCGGTT TCGCCCACCC ACGCCACTTCGGGGGAAGTG 301 TAGThis corresponds to the amino acid sequence <SEQ ID 1776; ORF 580>:

m580.pep.. 1 MDSPKVGCGW MVLPMSAASQ PISMARQTSP IISPPFGPTM PPPMMRPVSA 51SKISLVKPLS QPLAIARPEA AHGKLALVIL RPEALADSSV SPTHATSGEV 101 * m580/g58097.0% identity in 100 aa overlap        10        20        30        40        50        60 m580.pepMDSPKVGCGWMVLPMSAASQPISMARQTSPIISPPFGPTMPPPMMRPVSASKISLVKPLS|||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||| g580MDSPKVGCGWMVLPMSAASQPISMARQTSPIMSPPFGPTMPPPMMRPVSASKISLVKPLS        10        20        30        40        50        60        70        80        90       100 m580.pepQPLAIARPEAAHGKLALVILRPEALADSSVSPTHATSGEVX||||||||||||||||||||||:||||:||||||||||||| g580QPLAIARPEAAHGKLALVILRPDALADNSVSPTHATSGEVX        70        80        90       100The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1777>:

a580.seq 1 ATGGATTCGC CCAAGGTCGG GTGCGGGTGG ATGGTTTTGC CGATGTCTGC 51CGCGTCGCAG CCCATTTCGA TGGCAAGGCA GACTTCGCCG ATCATGTCGC 101 CACCGTTCGGACCGACAATG CCGCCGCCGA TGATGCGGCC GGTTTCAGCA 151 TCAAAAATCA GCTTGGTGAAACCATTGTCG CAACCGTTGG CAATCGCACG 201 GCCGGAAGCA GCCCATGGGA AGTTGGCTTTGGTGATTTTG CGGCCGGAGG 251 CTTTGGCAGA CAATTCGGTT TCGCCCACCC ATGCCACTTCAGGAGAAGTG 301 TAAThis corresponds to the amino acid sequence <SEQ ID 1778; ORF 580.a>:

a580.pep 1 MDSPKVGCGW MVLPMSAASQ PISMARQTSP IMSPPFGPTM PPPMMRPVSA 51SKISLVKPLS QPLAIARPEA AHGKLALVIL RPEALADNSV SPTHATSGEV 101 * m580/a58098.0% identity in 100 aa overlap        10        20        30        40        50        60 m580.pepMDSPKVGCGWMVLPMSAASQPISMARQTSPIISPPFGPTMPPPMMRPVSASKISLVKPLS|||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| a580MDSPKVGCGWMVLPMSAASQPISMARQTSPIMSPPFGPIMPPPMMRPVSASKISLVKPLS        10        20        30        40        50        60        70        80        90       100 m580.pepQPLAIARPEAAHGKLALVILRPEALADSSVSPTHATSGEVX||||||||||||||||||||||:||||:||||||||||||| a580QPLAIARPEAAHGKLALVILRPEALADNSVSPTHATSGEVX        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1779>:

g581.seq.. 1 atgcacttcg cccagcttgt gggtcaaacc ggtatagaac aaaatacgtt 51ctgtcgtcgt ggttttaccc gcatcgatat gggcggaaat accgatgttg 101 cggtacaggctgatcggggt cttacgagcc attttattag cctttcaaaa 151 ttagaaacgg aagtgagagaatgctttgtt ggcttcagcc atacggtgta 201 cttcttcacg ttttttcaac gcaccgccacggccttcgga cgcatcaatc 251 aactcgcctg ccaaacgcag atccatggat ttctcaccacgtttgcgggc 301 cgcgtcgcga acccaacgca ttgccaaagc cagacggcgt gaThis corresponds to the amino acid sequence <SEQ ID 1780; ORF 581.ng>:

g581.pep.. 1 MHFAQLVGQT GIEQNTFCRR GFTRIDMGGN TDVAVQADRG LTSHFISLSK 51LETEVRECFV GFSHTVYFFT FFQRTATAFG RINQLACQTQ IHGFLTTFAG 101 RVANPTHCQSQTA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1781>:

m581.seq.. 1 ATGCACTTCG CCCAGCTTGT GGGTCAAACC GGTATAGAAC AAAATACGTT 51CTGTCGTCGT GGTTTTACCC GCGTCAATAT GGGCGGAAAT ACCGATGTTA 101 CGGTACAGGCTGATCGGGGT CTTACGAGCC ATTTTATTAG CCTTTCAAAA 151 TTAGAAACGG AAGTGAGAGAATGCTTTGTT GGCTTCAGCC ATACGGTGTA 201 CTTCTTCACG TTTTTTCAAC GCACCGCCACGGCCTTCGGA CGCATCAATC 251 AATTCGCCTG CCAAACGCAG GTCCATGGAT TTCTCACCACGTTTGCGGGC 301 CGCATCGCGA ACCCAGCGCA TTGCCAAAGC CAAACGGCGT GAThis corresponds to the amino acid sequence <SEQ ID 1782; ORF 581>:

m581.pep.. 1 MHFAQLVGQT GIEQNTFCRR GFTRVNMGGN TDVTVQADRG LTSHFISLSK 51LETEVRECFV GFSHTVYFFT FFQRTATAFG RINQFACQTQ VHGFLTTFAG 101 RIANPAHCQSQTA* m581/g581 93.8% identity in 113 aa overlap        10        20        30        40        50        60 m581.pepMHFAQLVGQTGIEQNTFCRRGFTRVNMGGNTDVTVQADRGLTSHFISLSKLETEVRECFV||||||||||||||||||||||||::|||||||:|||||||||||||||||||||||||| g581MHFAQLVGQTGIEQNTFCRRGFTRIDMGGNTDVAVQADRGLTSHFISLSKLETEVRECFV        10        20        30        40        50        60        70        80        90       100       110 m581.pepGFSHTVYFFTFFQRTATAFGRINQFACQTQVHGFLTTFAGRIANPAHCQSQTAX||||||||||||||||||||||||:|||||:||||||||||:|||:|||||||| g581GFSHTVYFFTFFQRTATAFGRINQLACQTQIHGFLTTFAGRVANPTHCQSQTAX        70        80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1783>:

a581.seq 1 ATGCACTTCG CCCAGCTTGT GGGTCAAACC GGTATAGAAC AAAATACGTT 51CTGTCGTCGT GGTTTTACCC GCATCGATAT GGGCGGAAAT ACCGATGTTA 101 CGGTACAGGCTGATCGGGGT CTTACGAGCC ATTTTATTAG CCTTTCAAAA 151 TTAGAAACGG AAGTGAGAGAATGCTTTGTT GGCTTCAGCC ATACGGTGTA 201 CTTCTTCACG TTTTTTCAAC GCACCGCCACGGCCTTCGGA CGCATCAATC 251 AATTCGCCTG CCAAACGCAG GTCCATGGAT TTCTCACCACGTTTGCGGGC 301 CGCATCGCGA ACCCAGCGCA TTGCCAAAGC CAAACGGCGT GAThis corresponds to the amino acid sequence <SEQ ID 1784; ORF 581.a>:

a581.pep 1 MHFAQLVGQT GIEQNTFCRR GFTRIDMGGN TDVTVQADRG LTSHFISLSK 51LETEVRECFV GFSHTVYFFT FFQRTATAFG RINQFACQTQ VHGFLTTFAG 101 RINPAHCQSQTA* m581/a581 98.2% identity in 113 aa overlap        10        20        30        40        50        60 m581.pepMHFAQLVGQTGIEQNTFCRRGFTRVNMGGNTDVTVQADRGLTSHFISLSKLETEVRECFV||||||||||||||||||||||||::|||||||||||||||||||||||||||||||||| a581MHFAQLVGQTGIEQNTFCRRGFTRIDMGGNTDVTVQADRGLTSHFISLSKLETEVRECFV        10        20        30        40        50        60        70        80        90       100       110 m581.pepGFSHTVYFFTFFQRTATAFGRINQFACQTQVHGFLTTFAGRIANPAHCQSQTAX|||||||||||||||||||||||||||||||||||||||||||||||||||||| a581GFSHTVYFFTFFQRTATAFGRINQFACQTQVHGFLTTFAGRIANPAHCQSQTAX        70        80        90       100       110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1785>:

g582.seq.. 1 atgcgctata ttcttttgac aggactgttg ccgacggcat ccgcttttgg 51agagaccgcg ctgcaatgcg ccgctttgac ggacaatgtt acgcgtttgg 101 cgtgttacgacaggattttt gcggcacagc ttccgtcttc ggcagggcag 151 gaagggcagg agtcgaaagccgtactcaat ctgacggaaa ccgtccgcag 201 cagcttggat aagggcgagg cggtcattgttgttgaaaaa ggcggggatg 251 cgcttcctgc cgacagtgcg ggcgaaaccg ccgatatctatacgcctttg 301 agcctgatgt acgacttgga caaaaacgat ttgcgcgggc tgttgggcgt351 acgcgaacac aatccgatgt accttatgcc gttttggtat aacaattcgc 401ccaactatgc cccgagttcg ccgacgcgcg gtacgactgt acaggaaaaa 451 ttcggacagcagaaacgtgc ggaaaccaaa ttgcaggttt cgttcaaaag 501 caaaattgcc gaaaatttgtttaaaacccg cgcggatctg tggttcggct 551 acacccaaag atccgattgg cagatttacaaccaaggcag gaaatccgcg 601 ccgttccgca atacggatta caaacctgaa attttcctgacccagcctgt 651 gaaggcggat ttgccgttcg gcggcaggct gcgtatgctc ggtgcgggtt701 ttgtccacca gtccaacgga cagagccgtc ccgaatcgcg ttcgtggaac 751aggatttatg ccatggcagg catggaatgg ggcaaattga cggtgattcc 801 gcgcgtgtgggtgcgtgcgt tcgatcagag cggcgataaa aacgacaatc 851 ccgatattgc cgactatatggggtatggcg acgtgaagct gcagtaccgc 901 ctgaacgaca ggcagaatgt gtattccgtattgcgctaca accccaaaac 951 gggctacggc gcgattgaag ccgcctacac gtttccgattaagggcaaac 1001 tcaaaggcgt ggtacgcgga ttccacggtt acggcgagag cctgatcgac1051 tacaaccaca agcagaacgg tatcggtatc gggttgatgt tcaacgactg 1101ggacggcatc tgaThis corresponds to the amino acid sequence <SEQ ID 1786; ORF 582.ng>:

g582.pep .. 1 MRYILLTGLL PTASAFGETA LQCAALTDNV TRLACYDRIF AAQLPSSAGQ 51EGQESKAVLN LTETVRSSLD KGEAVIVVEK GGDALPADSA GETADIYTPL 101 SLMYDLDKNDLRGLLGVREH NPMYLMPFWY NNSPNYAPSS PTRGTTVQEK 151 FGQQKRAETK LQVSFKSKIAENLFKTRADL WFGYTQRSDW QIYNQGRKSA 201 PFRNTDYKPE IFLTQPVKAD LPFGGRLRMLGAGFVHQSNG QSRPESRSWN 251 RIYAMAGMEW GKLTVIPRVW VRAFDQSGDK NDNPDIADYMGYGDVKLQYR 301 LNDRQNVYSV LRYNPKTGYG AIEAAYTFPI KGKLKGVVRG FHGYGESLID351 YNHKQNGIGI GLMFNDWDGI *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1787>:

m582.seq .. 1 ATGCGCTATA TTCTTTTGAC AGGACTGTTG CCGATGGCAT CCGCTTTTGG 51AGAGACCGCG CTGCAATGCG CCGCTTTGAC GGACAATGTT ACGCGTTTGG 101 CGTGTTACGACAGGATTTTT GCGGCACAGC TTCCGTCTTC GGCAGGGCAG 151 GAAGGGCAGG AGTCGAAAGCCGTACTCAAT CTGACGGAAA CCGTCCGCAG 201 CAGCCTGGAT AAGGGCGAGG CGGTCATTGTTGTTGAAAAA GGCGGGGATG 251 CGCTTCCTGC CGACAGTGCG GGCGAAACCG CCGACATCTATACGCCTTTG 301 AGCCTGATGT ACGACTTGGA CAAAAACGAT TTGCGCGGGC TGTTGGGCGT351 ACGCGAACAC AATCCGATGT ACCTTATGCC GCTCTGGTAC AACAATTCGC 401CCAACTATGC CCCGGGTTCG CCGACGCGCG GTACGACTGT ACAGGAAAAA 451 TTCGGACAGCAGAAACGTGC GGAAACCAAA TTGCAGGTTT CGTTCAAAAG 501 CAAAATTGCC GAAGATTTGTTTAAAACCCG CGCGGATCTG TGGTTCGGCT 551 ACACCCAAAG ATCCGATTGG CAGATTTACAACCAAGGCAG GAAATCCGCG 601 CCGTTCCGCA ATACGGATTA CAAACCTGAA ATTTTCCTGACCCAGCCTGT 651 GAAGGCGGAT TTGCCGTTCG GCGGCAGGCT GCGTATGCTC GGTGCGGGTT701 TTGTCCACCA GTCCAACGGA CAGAGCCGTC CCGAATCGCG TTCGTGGAAC 751AGGATTTACG CCATGGCAGG CATGGAATGG GGCAAATTGA CGGTGATTCC 801 GCGCGTGTGGGTGCGTGCGT TCGATCAGAG CGGCGATAAA AACGACAATC 851 CCGATATTGC CGACTATATGGGGTATGGCG ACGTGAAGCT GCAGTACCGC 901 CTGAACGACA GGCAGAATGT GTATTCCGTATTGCGCTACA ACCCCAAAAC 951 GGGCTACGGC GCGATTGAAG CCGCCTACAC GTTTCCGATTAAGGGCAAAC 1001 TCAAAGGCGT GGTACGCGGA TTCCACGGTT ACGGCGAGAG CCTGATCGAC1051 TACAACCACA AGCAGAACGG TATCGGTATC GGGTTGATGT TCAACGACTT 1101GGACGGCATC TGAThis corresponds to the amino acid sequence <SEQ ID 1788; ORF 582>:

m582.pep 1 MRYILLTGLL PMASAFGETA LQCAALTDNV TRLACYDRIF AAQLPSSAGQ 51EGQESKAVLN LTETVRSSLD KGEAVIVVEK GGDALPADSA GETADIYTPL 101 SLMYDLDKNDLRGLLGVREH NPMYLMPLWY NNSPNYAPGS PTRGTTVQEK 151 FGQQKRAETK LQVSFKSKIAEDLFKTRADL WFGYTQRSDW QIYNQGRKSA 201 PFRNTDYKPE IFLTQPVKAD LPFGGRLRMLGAGFVHQSNG QSRPESRSWN 251 RIYAMAGMEW GKLTVIPRVW VRAFDQSGDK NDNPDIADYMGYGDVKLQYR 301 LNDRQNVYSV LRYNPKTGYG AIEAAYTFPI KGKLKGVVRG FHGYGESLID351 YNHKQNGIGI GLMFNDLDGI * m582/g582 98.6% identity in 370 aa overlap        10        20        30        40        50        60 m582.pepMRYILLTGLLPMASAFGETALQCAALTDNVTRLACYDRIFAAQLPSSAGQEGQESKAVLN||||||||||| |||||||||||||||||||||||||||||||||||||||||||||||| g582MRYILLTGLLPTASAFGETALQCAALTDNVTRLACYDRIFAAQLPSSAGQEGQESKAVLN        10        20        30        40        50        60        70        80        90       100       110       120 m582.pepLTETVRSSLDKGEAVIVVEKGGDALPADSAGETADIYTPLSLMYDLDKNDLRGLLGVREH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g582LTETVRSSLDKGEAVIVVEKGGDALPADSAGETADIYTPLSLMYDLDKNDLRGLLGVREH        70        80        90       100       110       120       130       140       150       160       170       180 m582.pepNPMYLMPLWYNNSPNYAPGSPTRGTTVQEKFGQQKRAETKLQVSFKSKIAEDLFKTRADL|||||||:||||||||||:||||||||||||||||||||||||||||||||:|||||||| g582NPMYLMPFWYNNSPNYAPSSPTRGTTVQEKFGQQKRAETKLQVSFKSKIAENLFKTRADL       130       140       150       160       170       180       190       200       210       220       230       240 m582.pepWFGYTQRSDWQIYNQGRKSAPFRNTDYKPEIFLTQPVKADLPFGGRLRMLGAGFVHQSNG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g582WEGYTQRSDWQIYNQGRKSAPFRNTDYKPEIFLTQPVKADLPFGGRLRMLGAGFVHQSNG       190       200       210       220       230       240       250       260       270       280       290       300 m582.pepQSRPESRSWNRIYAMAGMEWGKLTVIPRVWVRAFDQSGDKNDNPDIADYMGYGDVKLQYR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g582QSRPESRSWNRIYAMAGMEWGKLTVIPRVWVRAFDQSGDKNDNPDIADYMGYGDVKLQYR       250       260       270       280       290       300       310       320       330       340       350       360 m582.pepLNDRQNVYSVLRYNPKTGYGAIEAAYTFPIKGKLKGVVRGFHGYGESLIDYNHKQNGIGI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g582LNDRQNVYSVLRYNPKTGYGAIEAAYTFPIKGKLKGVVRGFHGYGESLIDYNHKQNGIGI       310       320       330       340       350       360        370m582.pep GLMFNDLDGIX |||||| |||| g582 GLMFNDWDGIX        370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1789>:

a582.seq 1 ATGCGCTATA TTCTTTTGAC AGGACTGTTG CCGATGGCAT CCGCTTTTGG 51AGAGACCGCG CTGCAATGCG CCGCTTTGAC GGACAATGTT ACGCGTTTGG 101 CGTGTTACGACAGGATTTTT GCGGCACAGC TTCCGTCTTC GGCAGGGCAG 151 GAAGGGCAGG AGTCGAAAGCCGTACTCAAT CTGACGGAAA CCGTCCGCAG 201 CAGCCTGGAT AAGGGCGAGG CGGTCATTGTTGTTGAAAAA GGCGGGGATG 251 CGCTTCCTGC CGACAGTGCG GGCGAAACCG CCGACATCTATACGCCTTTG 301 AGCCTGATGT ACGACTTGGA CAAAAACGAT TTGCGCGGGC TGTTGGGCGT351 ACGCGAACAC AATCCGATGT ACCTTATGCC GCTCTGGTAC AACAATTCGC 401CCAACTATGC CCCGGGTTCG CCGACGCGCG GTACGACTGT ACAGGAAAAA 451 TTCGGACAGCAGAAACGTGC GGAAACCAAA TTGCAGGTTT CGTTCAAAAG 501 CAAAATTGCC GAAGATTTGTTTAAAACCCG CGCGGATCTG TGGTTCGGCT 551 ACACCCAAAG ATCCGATTGG CAGATTTACAACCAAGGCAG GAAATCCGCG 601 CCGTTCCGCA ATACGGATTA CAAACCTGAA ATTTTCCTGACCCAGCCTGT 651 GAAGGCGGAT TTGCCGTTCG GCGGCAGGCT GCGTATGCTC GGTGCGGGTT701 TTGTCCACCA GTCCAACGGA CAGAGCCGTC CCGAATCGCG TTCGTGGAAC 751AGGATTTACG CCATGGCAGG CATGGAATGG GGCAAATTGA CGGTGATTCC 801 GCGCGTGTGGGTGCGTGCGT TCGATCAGAG CGGCGATAAA AACGACAATC 851 CCGATATTGC CGACTATATGGGGTATGGCG ACGTGAAGCT GCAGTACCGC 901 CTGAACGACA GGCAGAATGT GTATTCCGTATTGCGCTACA ATCCCAAAAC 951 GGGCTACGGC GCGATTGAAG CCGCCTACAC GTTTCCGATTAAGGGCAAAC 1001 TCAAAGGCGT GGTACGCGGA TTCCACGGTT ACGGCGAGAG CCTGATCGAC1051 TACAACCACA AGCAGAACGG TATCGGTATC GGGTTGATGT TCAACGACTT 1101GGACGGCATC TGAThis corresponds to the amino acid sequence <SEQ ID 1790; ORF 582.a>:

a582.pep 1 MRYILLTGLL PMASAFGETA LQCAALTDNV TRLACYDRIF AAQLPSSAGQ 51EGQESKAVLN LTETVRSSLD KGEAVIVVEK GGDALPADSA GETADIYTPL 101 SLMYDLDKNDLRGLLGVREH NPMYLMPLWY NNSPNYAPGS PTRGTTVQEK 151 FGQQKRAETK LQVSFKSKIAEDLFKTRADL WFGYTQRSDW QIYNQGRKSA 201 PFRNTDYKPE IFLTQPVKAD LPFGGRLRMLGAGFVHQSNG QSRPESRSWN 251 RIYAMAGMEW GKLTVIPRVW VRAFDQSGDK NDNPDIADYMGYGDVKLQYR 301 LNDRQNVYSV LRYNPKTGYG AIEAAYTFPI KGKLKGVVRG FHGYGESLID351 YNHKQNGIGI GLMFNDLDGI * m582/a582 100.0% identity in 370 aa overlap        10        20        30        40        50        60 m582.pepMRYILLTGLLPMASAFGETALQCAALTDNVTRLACYDRIFAAQLPSSAGQEGQESKAVLN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a582MRYILLTGLLPMASAFGETALQCAALTDNVTRLACYDRIFAAQLPSSAGQEGQESKAVLN        10        20        30        40        50        60        70        80        90       100       110       120 m582.pepLTETVRSSLDKGEAVIVVEKGGDALPADSAGETADIYTPLSLMYDLDKNDLRGLLGVREH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a582LTETVRSSLDKGEAVIVVEKGGDALPADSAGETADIYTPLSLMYDLDKNDLRGLLGVREH        70        80        90       100       110       120       130       140       150       160       170       180 m582.pepNPMYLMPLWYNNSPNYAPGSPTRGTTVQEKFGQQKRAETKLQVSFKSKIAEDLFKTRADL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a582NPMYLMPLWYNNSPNYAPGSPTRGTTVQEKFGQQKRAETKLQVSFKSKIAEDLFKTRADL       130       140       150       160       170       180       190       200       210       220       230       240 m582.pepWFGYTQRSDWQIYNQGRKSAPFRNTDYKPEIFLTQPVKADLPFGGRLRMLGAGFVHQSNG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a582WFGYTQRSDWQIYNQGRKSAPFRNTDYKPEIFLTQPVKADLPFGGRLRMLGAGFVHQSNG       190       200       210       220       230       240       250       260       270       280       290       300 m582.pepQSRPESRSWNRIYAMAGMEWGKLIVIPRVWVRAFDQSGDKNDNPDIADYMGYGDVKLQYR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a582QSRPESRSWNRIYAMAGMEWGKLIVIPRVWVRAFDQSGDKNDNPDIADYMGYGDVKLQYR       250       260       270       280       290       300       310       320       330       340       350       360 m582.pepLNDRQNVYSVLRYNPKTGYGAIEAAYTFPIKGKLKGVVRGFHGYGESLIDYNHKQNGIGI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a582LNDRQNVYSVLRYNPKTGYGAIEAAYTFPIKGKLKGVVRGFHGYGESLIDYNHKQNGIGI       310       320       330       340       350       360        370m582.pep GLMFNDLDGIX ||||||||||| a582 GLMFNDLDGIX        370The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1791>:

g583.seq.. 1 atgataattg accaaagcca aatatttacc catcttgcct tctgtgcctt 51ttgcgggatt ggagccgtaa ctgccggcaa tcgactgcat aatcggatgt 101 ataatgccgccgccgcgcgc ggtattggaa ggggtaacgg gagccagcag 151 cagttcggaa agagcgagactgtaaccgat gcccagcgtt tttcttccaa 201 aaacggcgat aaacaaatat ccgatacgcatccccagccc tgttttgagc 251 aaaccgcgcg aaatcataac tgcgatggca atcagccaaatcaacggatt 301 ggcgaacgca ctcaacgcat cgctcatcgc cgcgcccggt ttgtcggcgg351 ttacgccggt tactgcgacc aacccgacgg caataatcga cagcgcgccc 401aacggcataa ccttgccgat aatggcggca atcacaccga caaacatagc 451 cagcagcgtccaagcctgag gcttgacccc gtcgggtacg ggcagtgcca 501 aaaccagggc gcacaatactgcggcaatgg cgaggggtat cggtttgaaa 551 cccaatttca tcatattgac ctccgtaaaaaagaccgtcc cgaaaaatcg 601 gaaaaataaThis corresponds to the amino acid sequence <SEQ ID 1792; ORF 583.ng>:

g583.pep.. 1 MIIDQSQIFT HLAFCAFCGI GAVTAGNRLH NRMYNAAAAR GIGRGNGSQQ 51QFGKSETVTD AQRFSSKNGD KQISDTHPQP CFEQTARNHN CDGNQPNQRI 101 GERTQRIAHRRARFVGGYAG YCDQPDGNNR QRAQRHNLAD NGGNHTDKHS 151 QQRPSLRLDP VGYGQCQNQGAQYCGNGEGY RFETQFHHID LRKKDRPEKS 201 EK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1793>:

m583.seq.. 1 ATGATAGTTG ACCAAAGCCA AATATTTACC CATCTTGCCT TCTGTGCCTT 51TTGCGGGATT GGAGCCGTAA CTGCCGGCAA TCGACTGCAT AATCGGATGT 101 ATAATGCCGCCGCCGCGCGC GGTATTGGAA GGGGTAACGG GAGCCAGCAG 151 CAGTTCGGAA AGAGCGAGACTGTAACCGAT GCCCAGCGTT TTTCTTCCAA 201 AAACGGCGAT AAACAAATAT CCGATACGCATCCCCAGCCC TGTTTTGAGC 251 AAACCGCGCG AAATCATAAC TGCGATGGCA ATCAGCCAAATCAACGGATT 301 GGCGAACGCA CTCAACGCAT CGCTCATCGC CGCGCCCGGT TTGTCGGCGG351 TTACGCCGGT TACTGCGACC AACCCGACGG CAATAATCGA CAGCGCGCCC 401AACGGCATGG CCTTGCCGAT AATGGCGGCA ATCACACCGA CAAACATGGC 451 CAGCAGCGTCCAAGCCTGAG GCTTGACCCC GTCGGGTACG GGCAGTGCCA 501 AAACCAGGGC GCACAATACTGCGGCAATGG CGAGGGGTAT CGGTTTGAAA 551 CCCAATTTCA TCATATTGAC CTCCGTAAAAAAGACCGTCC CGAAAAATCG 601 GAAAAATAAThis corresponds to the amino acid sequence <SEQ ID 1794; ORF 583>:

m583.pep.. 1 MIVDQSQIFT HLAFCAFCGI GAVTAGNRLH NRMYNAAAAR GIGRGNGSQQ 51QFGKSETVTD AQRFSSKNGD KQISDTHPQP CFEQTARNHN CDGNQPNQRI 101 GERTQRIAHRRARFVGGYAG YCDQPDGNNR QRAQRHGLAD NGGNHTDKHG 151 QQRPSLRLDP VGYGQCQNQGAQYCGNGEGY RFETQFHHID LRKKDRPEKS 201 EK* m583/g583 98.5% identity in 202aa overlap         10        20        30        40        50        60m583.pep MIVDQSQIFTHLAFCAFCGIGAVTAGNRLHNRMYNAAAARGIGRGNGSQQQFGKSETVTD||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g583MIIDQSQIFTHLAFCAFCGIGAVTAGNRLHNRMYNAAAARGIGRGNGSQQQFGKSETVTD        10        20        30        40        50        60        70        80        90       100       110       120 m583.pepAQRFSSKNGDKQISDTHPQPCFEQTARNHNCDGNQPNQRIGERTQRIAHRRARFVGGYAG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g583AQRFSSKNGDKQISDTHPQPCFEQTARNHNCDGNQPNQRIGERTQRIAHRRARFVGGYAG        70        80        90       100       110       120       130       140       150       160       170       180 m583.pepYCDQPDGNNRQRAQRHGLADNGGNHTDKHGQQRPSLRLDPVGYGQCQNQGAQYCGNGEGY||||||||||||||||:||||||||||||:|||||||||||||||||||||||||||||| g583YCDQPDGNNRQRAQRHNLADNGGNHTDKHSQQRPSLRLDPVGYGQCQNQGAQYCGNGEGY       130       140       150       160       170       180       190       200 m583.pep RFETQFHHIDLRKKDRPEKSEKX||||||||||||||||||||||| g583 RFETQFHHIDLRKKDRPEKSEKX       190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1795>:

a583.seq 1 ATGATAGTTG ACCAAAGCCA AATATTTACC CATCTTGCCT TCTGTGCCTT 51TTGCGGGATT GGAGCCGTAA CTGCCGGCAA TCGACTGCAT AATCGGATGT 101 ATAATGCCGCCGCCGCGCGC GGTATTGGAA GGGGTAACGG GAGCCAGCAG 151 CAGTTCGGAA AGAGCGAGACTGTAACCGAT GCCCAGCGTT TTTCTTCCAA 201 AAACGGCGAT AAACAAATAT CCGATACGCATCCCCAGCCC TGTTTTGAGC 251 AAACCGCGCG AAATCATAAC TGCGATGGCA ATCAGCCAAATCAACGGATT 301 GGCGAACGCA CTCAACGCAT CGCTCATCGC CGCACCCGGT TTGTCGGCGG351 TTACGCCGGT TACTGCGACC AACCCGACGG CAATAATCGA CAGCGCACCC 401AACGGCATGG CCTTGCCGAT AATGGCGGCA ATCACACCGA TAAACATGGC 451 CAGCAGCGTCCAAGCCTGAG GCTTGACCCC GTCGGGTACG GGCAGTGCCA 501 AAACCAAGGC GCACAATACTGCGGCAATGG CGAGGGGTAT CGGTTTGAAA 551 CCCAATTTCA TCATATTGAC CTCCGTAAAAAAGACCGTCC CGAAAAATCG 601 GAAAAATAAThis corresponds to the amino acid sequence <SEQ ID 1796; ORF 583.a>:

a583.pep 1 MIVDQSQIFT HLAFCAFCGI GAVTAGNRLH NRMYNAAAAR GIGRGNGSQQ 51QFGKSETVTD AQRFSSKNGD KQISDTHPQP CFEQTARNHN CDGNQPNQRI 101 GERTQRIAHRRTRFVGGYAG YCDQPDGNNR QRTQRHGLAD NGGNHTDKHG 151 QQRPSLRLDP VGYGQCQNQGAQYCGNGEGY RFETQFHHID LRKKDRPEKS 201 EK* m583/a583 99.0% identity in 202aa overlap         10        20        30        40        50        60m583.pep MIVDQSQIFTHLAFCAFCGIGAVTAGNRLHNRMYNAAAARGIGRGNGSQQQFGKSETVTD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a583MIVDQSQIFTHLAFCAFCGIGAVTAGNRLHNRMYNAAAARGIGRGNGSQQQFGKSETVTD        10        20        30        40        50        60        70        80        90       100       110       120 m583.pepAQRFSSKNGDKQISDTHPQPCFEQTARNHNCDGNQPNQRIGERTQRIAHRRARFVGGYAG|||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||| a583AQRFSSKNGDKQISDTHPQPCFEQTARNHNCDGNQPNQRIGERTQRIAHRRTRFVGGYAG        70        80        90       100       110       120       130       140       150       160       170       180 m583.pepYCDQPDGNNRQRAQRHGLADNGGNHTDKHGQQRPSLRLDPVGYGQCQNQGAQYCGNGEGY||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| a583YCDQPDGNNRQRTQRHGLADNGGNHTDKHGQQRPSLRLDPVGYGQCQNQGAQYCGNGEGY       130       140       150       160       170       180       190       200 m583.pep RFETQFHHIDLRKKDRPEKSEKX||||||||||||||||||||||| a583 RFETQFHHIDLRKKDRPEKSEKX       190       200The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1797>:

g584.seq.. 1 atgctgcgtt ctattttggc ggcttccctg ctggcggtat cttttccggc 51ggcggctgag gcattgaatt acaatattgt cgaattttcc gaatcggcgg 101 gtatcgaggtggctcaggat acaatgtccg cgcgtttcca ggtggcggcg 151 gaaggacggg acaaaaatgccgtcaatgcc gagtttgtta aaaaattcaa 201 caatttcacc agaaaatcga aaaatggtagctttaaaacc gaattggtat 251 cgcgcagtgc gatgccgcgc tatcaatata ccaacggcagacgcattcaa 301 acaggctggg aggagcgtgc ggaatttaag gcggagggca gggattttga351 tgctttaaac cgttttattg ctgatgttca gacggatgct tcgcttgaag 401ataccgattt cagcgtgtcg cgcgaacgcc gaaacgaggt catcgatcag 451 gtcagcaaggatgccgtttt gcgtttcaag gcgcgtgccg aaaaactggc 501 gggcgttctg ggtgcgtccggttataaaat cgtcaaattg aattttgggc 551 aaatcggcag ccatattgcg ggcgatggggctgttcgggc aaaaatgctg 601 cgcgcgatgc cgatggcggc aagcgtcaat atgaagggtacggattcagc 651 cgcaccgggt gtggaggaaa tcagcatcag catcaatggg acggttcagt701 tctaaThis corresponds to the amino acid sequence <SEQ ID 1798; ORF 584.ng>:

g584.pep Length:.. 1 MLRSILAASL LAVSFPAAAE ALNYNIVEFS ESAGIEVAQDTMSARFQVAA 51 EGRDKNAVNA EFVKKFNNFT RKSKNGSFKT ELVSRSAMPR YQYTNGRRIQ 101TGWEERAEFK AEGRDFDALN RFIADVQTDA SLEDTDFSVS RERRNEVIDQ 151 VSKDAVLRFKARAEKLAGVL GASGYKIVKL NFGQIGSHIA GDGAVRAKML 201 RAMPMAASVN MKGTDSAAPGVEEISISING TVQF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1799>:

m584.seq.. 1 ATGTTGCGTC TTGTTTTGGC GGCTTCGCTG TCGGCGGTAT CTTTTCCGGC 51AGCGGCTGAA GCATTGAATT ACAATATTGT CGAATTTTCC GAATCGGCGG 101 GTGTCGAGGTGGCTCAGGAT ACAATGTCCG CACGTTTCCA AGTGACGGCG 151 GAAGGACGGG ACAAAAATGCCGTCAATGCT GAGTTTGTTA AAAAATTCAA 201 CAAGTTCATC AGAAAATCGA AAAATGGTAGCTTTAAAACC GAATTGGTAT 251 CGCGCAGTGC GATGCCGCGC TATCAATATA CCAACGGCAGACGCATTCAA 301 ACAGGCTGGG AGGAGCGTGC GGAATTTAAG GTCGAAGGTA GAGATTTTGA351 TGAGTTAAAC CGTTTTATTG CCGATATTCA AGCAGATGCC GCGTTGGmAT 401ATACGGATTT CCATGTGTCG CGCGAACGCC GCAACGAGGT CATCkATCAG 451 GTCAGCAAGGATGCCGTTTT GCGTTTCAAG GCGCGTGCCG AAAAGTTGGC 501 GGGCGTTTTG GGTGCGTCCGGTTATAAAAT CGTCAAATTG AATTTGGGAC 551 ACATCGGCAG CCATATCGCG GGAGGGGGAGCTGCTCAGGC AAAAATGCTT 601 CGTGCCATGC CGATGGCGGC AAGCGTCAAT ATGGAGGGTGCGGATTCCGC 651 CGCGCCTGGT GTGGAGGAAA TCAGCATCAG CGTCAATGGG ACGGTTCAGT701 TCTGAThis corresponds to the amino acid sequence <SEQ ID 1800; ORF 584>:

m584.pep.. 1 MLRLVLAASL SAVSFPAAAE ALNYNIVEFS ESAGVEVAQD TMSARFQVTA 51EGRDKNAVNA EFVKKFNKFI RKSKNGSFKT ELVSRSAMPR YQYTNGRRIQ 101 TGWEERAEFKVEGRDFDELN RFIADIQADA ALXYTDFHVS RERRNEVIXQ 151 VSKDAVLRFK ARAEKLAGVLGASGYKIVKL NLGHIGSHIA GGGAAQAKML 201 RAMPMAASVN MEGADSAAPG VEEISISVNGTVQF* m584/g584 89.7% identity in 234 aa overlap        10        20        30        40        50        60 m584.pepMLRLVLAASLSAVSFPAAAEALNYNIVEFSESAGVEVAQDTMSARFQVTAEGRDKNAVNA||| :||||| |||||||||||||||||||||||:|||||||||||||:||||||||||| g584MLRSILAASLLAVSFPAAAEALNYNIVEFSESAGIEVAQDTMSARFQVAAEGRDKNAVNA        10        20        30        40        50        60        70        80        90       100       110       120 m584.pepEFVKKFNKFIRKSKNGSFKTELVSRSAMPRYQYTNGRRIQTGWEERAEFKVEGRDFDELN|||||||:| ||||||||||||||||||||||||||||||||||||||||:|||||| || g584EFVKKENNFTRKSKNGSFKTELVSRSAMPRYQYTNGRRIQTGWEERAEFKAEGRDFDALN        70        80        90       100       110       120       130       140       150       160       170       180 m584.pepRFIADIQADAALXYLDFHVSRERRNEVIXQVSKDAVLRFKARAEKLAGVLGASGYKIVKL|||||:|:||:|  ||| |||||||||| ||||||||||||||||||||||||||||||| g584RFIADVQTDASLEDTDFSVSRERRNEVIDQVSKDAVLRFKARAEKLAGVLGASGYKIVKL       130       140       150       160       170       180       190       200       210       220       230 m584.pepNLGHIGSHIAGGGAAQAKMLRAMPMAASVNMEGADSAAPGVEEISISVNGTVQFX|:|:||||||| ||::|||||||||||||||:|:|||||||||||||:||||||| g584NFGQIGSHIAGDGAVRAKMLRAMPMAASVNMKGTDSAAPGVEEISISINGTVQFX       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1801>:

a584.seq 1 ATGTTGCGTT CTATTTTGGC GGCTTCCCTG CTG....... .......... 51.......... .......... .....ATTGT CGAATTTTCT GAATCGGCGG 101 GTGTCGAGGCGGTTCAGGAT ACAATGTCCG CACGTTTCCA AGTGACGGCG 151 GAAGGACGGG ACAAAAATGCCGTCAATGCC GAGTTTGTTA AAAAATTCAA 201 CAATTTCACC AGAAAATCAA AAAATGGTAGCTTTAAAACC GAATTGGTAT 251 CGCGCAGTGC GATGCCGCGC TATCAATATA CCAACGGCAGACGCATTCAA 301 ACAGGTTGGG AGGAGCGTGC GGAATTTAAG GTCGAGGGTA GGAATTTTGA351 TGCGTTGAAC CGTTTTATTG CCGATGTTCA GGCAGATGCC GCGTTGGAAT 401ATACGGATTT CCATGTGTCG CGCGAACGCC GCAACGAGGT CATCGATCAG 451 GTCAGCAAGGATGCCGTTTT GCGTTTCAAG GCGCGTGCCG AAAAGTTGGC 501 GGGCGTTTTG GGTGCGTCCGGTTATAAAAT CGTCAAATTG AATTTGGGAC 551 ACATCGGCAG CCATATCGCG GGAGGGGGAGCTGCTCAGGC AAAAATGCTT 601 CGTGCCATGC CGATGGCGGC AAGCGTCAAT ATGGAGGGTGCGGATTCCGC 651 CGCGCCTGGT GTGGAGGAAA TCAGCATCAG CGTCAATGGG ACGGTTCAGT701 TCTGAThis corresponds to the amino acid sequence <SEQ ID 1802; ORF 584.a>:

a584.pep 1 MLRSILAASL L......... .....IVEFS ESAGVEAVQD TMSARFQVTA 51EGRDKNAVNA EFVKKFNNFT RKSKNGSFKT ELVSRSAMPR YQYTNGRRIQ 101 TGWEERAEFKVEGRNFDALN RFIADVQADA ALEYTDFHVS RERRNEVIDQ 151 VSKDAVLRFK ARAEKLAGVLGASGYKIVKL NLGHIGSHIA GGGAAQAKML 201 RAMPMAASVN MEGADSAAPG VEEISISVNGTVQF* m584/a584 88.9% identity in 234 aa overlap        10        20        30        40        50        60 m584.pepMLRLVLAASLSAVSFPAAAEALNYNIVEFSESAGVEVAQDTMSARFQVTAEGRDKNAVNA||| :|||||||||||||||||||||||||||||||::|||||||||||||||||||||| a584MLRSILAASLL--------------IVEFSESAGVEAVQDTMSARFQVTAEGRDKNAVNA        10                      20        30        40        70        80        90       100       110       120 m584.pepEFVKKFNKFIRKSKNGSFKTELVSRSAMPRYQYTNGRRIQTGWEERAEFKVEGRDFDELN|||||||:| ||||||||||||||||||||||||||||||||||||||||||||:|| || a584EFVKKFNNFTRKSKNGSFKTELVSRSAMPRYQYTNGRRIQTGWEERAEFKVEGRNFDALN  50        60        70        80        90       100       130       140       150       160       170       180 m584.pepRFIADIQADAALXYTDFHVSRERRNEVIXQVSKDAVLRFKARAEKLAGVLGASGYKIVKL|||||:|||||| ||||||||||||||| ||||||||||||||||||||||||||||||| a584RFIADVQADAALEYTDFHVSRERRNEVIDQVSKDAVLRFKARAEKLAGVLGASGYKIVKL 110       120       130       140       150       160       190       200       210       220       230 m584.pepNLGHIGSHIAGGGAAQAKMLRAMPMAASVNMEGADSAAPGVEEISISVNGTVQFX||||||||||||||||||||||||||||||||||||||||||||||||||||||| a584NLGHIGSHIAGGGAAQAKMLRAMPMAASVNMEGADSAAPGVEEISISVNGTVQFX 170       180       190       200       210       220The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1803>:

g585.seq.. 1 atgaaactgt tccaacgcat tttcgccaca ttttgcgcgg ttatcgtctg 51cgcaatcttt gtggcgagtt tttctttttg gctggtgcag aacacccttg 101 ccgaaaaccaattcaaccaa cgccgcacca tcgaaaccac attgatgggc 151 agcattattt ccgcattcaagacacggggc gacaacggcg cgcgcgaaat 201 cctgaccgaa tggaaaaaca gccccgtctcatccgccgtt tacgtcatac 251 agggcgacga gaaaaaagac atcttaaacc gctatatcgacaattacacc 301 atagaacgcg cccggctgtt tgccgccaac aacccccatt ccaaccttgt351 ccgcatcgaa tacgaccgtt tcggcgaaga atacctgttc ttcattaaag 401gctgggacaa ccaccaggca caacgcctgc ccagcccgct gtttatcccg 451 ggcctgccgcttgccccgat ttggcacgaa ttcatcatcc tctccttcat 501 catcattgtc ggactgctgatggcatatat ccttgccggc aacattgcca 551 aacccatcag aatcttaggc aacggcatggacagggtggc agaacgagaa 601 cttgaagacc gcgtttgcca acaggttcgc gaccgcgacgacgaattggc 651 cgatgttgcc atgcaattcg acacaatggt ggaaaaactg gaataaThis corresponds to the amino acid sequence <SEQ ID 1804; ORF 585.ng>:

g585.pep.. 1 MKLFQRIFAT FCAVIVCAIF VASFSFWLVQ NTLAENQFNQ RRTIETTLMG 51SIISAFKTRG DNGAREILTE WKNSPVSSAV YVIQGDEKKD ILNRYIDNYT 101 IERARLFAANNPHSNLVRIE YDRFGEEYLF FIKGWDNHQA QRLPSPLFIP 151 GLPLAPIWHE FIILSFIIIVGLLMAYILAG NIAKPIRILG NGMDRVAERE 201 LEDRVCQQVR DRDDELADVA MQFDTMVEKL E*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1805>:

m585.seq.. 1 ATGAAACTGT TCCAACGCAT TTTCGCCACA TTTTGCGCGG TTATCGTCTG 51TGCAATCTTT GTGGCGAGTT TTTCTTTCTG GCTGGTGCAG AACACCCTTG 101 CCGAAAACCAGTTCAACCAA CGCCGCACCA TCGAAACCAC TTTGATGGGC 151 AGCATCATTT CCGCATTCCGGGCACGCGGG GACGCGGGTG CGCGCGAAAT 201 CCTGACGGAA TGGAAAGACA GCCCCGTCTCATCGGGCGTG TACGTTATAC 251 AGGGCGACGA GAAAAAAGAT ATCCTGAACC GGTATATCGACAGCTATACC 301 ATCGAACGCG CCCGGCTTTT CGCCGCCGGA CACCCGCATT CCAACCTCGT351 CCATATCGAA TACGACCGCT TCGGCGAAGA ATACCTGTTC TTCACCAAAG 401ACTGGGACAA ACTCCAAGCC CGCCGCCTGC CCAGCCCCCT GTTGATCCCC 451 GGCCTGCCGCTCGCCCCGAT TTGGCACGAA CTCATCATAT TGTCCTTCAT 501 CATCATCGTC GGACTGCTGATGGCATATAT CCTCGCCGGC AACATTGCCA 551 AACCCATCAG AATCTTAGGC AACGGCATGGACAGGGTGGC AAACGGAGAA 601 CTTGAAACCC GTATCTCCCA ACAGGTCGAC GACCGCGACGACGAATTGTC 651 CCATCTTGCC ATCCAATTCG ACAAAATGGT GGAAAAACTC GAAAAACTCG701 TTGCCAAAGA ACGCCACCTG CTCCATCACG TCTCCCATGA AATGCGTTCT 751CCCCTTGCGC GCATGCAGGC AATTGTCGGA CTGATTCAGG CGCAGCCCCA 801 AAAACAGGAGCAATATCTCA AACGGCTGGA AGGCGAACTG ACCCGCATGG 851 ATACGCTGGC CGGGGAACTGTTAACCCTGT CCCGTCTCGA AACTTCCAAT 901 ATGGCTTTGG AAAAAGAAAG CCTGAAACTCCTGCCCTTCC TGGGCAACCT 951 GGTAGAAGAC AATCAAAGCA TTGCCCAGAA AAACGGACAAACGGTTACCC 1001 TGTCTGCCGA CGGAAAAATC CCCGAAAACA CAACCATCCT TGCCAACGAA1051 AGCTACCTGT ACCGCGCCTT CGACAACGTC ATCCGCAACG CCGTCAACTA 1101CAGTCCCGAA GGCAGCACCA TCCTGATCAA CATCGGACAA GACCACAAAC 1151 ACTGGATAATCGACGTTACC GACAACGGCC CCGGCGTGGA CGAAATGCAG 1201 CTCCCGCACA TCTTCACCGCTTTCTACCGT GCAGACTCCA GTGCCAACAA 1251 ACCCGGAACA GGACTGGGGC TTGCATTGACCCAACATATT ATTGAACAGC 1301 ACTGCGGCAA AATCATCGCC GAAAACATCA AACCGAACGGTCTGCGGATG 1351 CGCTTTATCC TGCCCAAGAA AAAAACCGGT TCCAAAACAG AAAAAAGTGC1401 GAACTGAThis corresponds to the amino acid sequence <SEQ ID 1806; ORF 585>:

m585.pep.. 1 MKLFQRIFAT FCAVIVCAIF VASFSFWLVQ NTLAENQFNQ RRTIETTLMG 51SIISAFRARG DAGAREILTE WKDSPVSSGV YVIQGDEKKD ILNRYIDSYT 101 IERARLFAAGHPHSNLVHIE YDRFGEEYLF FTKDWDKLQA RRLPSPLLIP 151 GLPLAPIWHE LIILSFIIIVGLLMAYILAG NIAKPIRILG NGMDRVANGE 201 LETRISQQVD DRDDELSHLA IQFDKMVEKLEKLVAKERHL LHHVSHEMRS 251 PLARMQAIVG LIQAQPQKQE QYLKRLEGEL TRMDTLAGELLTLSRLETSN 301 MALEKESLKL LPFLGNLVED NQSIAQKNGQ TVTLSADGKI PENTTILANE351 SYLYRAFDNV IRNAVNYSPE GSTILINIGQ DHKHWIIDVT DNGPGVDEMQ 401LPHIFTAFYR ADSSANKPGT GLGLALTQHI IEQHCGKIIA ENIKPNGLRM 451 RFILPKKKTGSKTEKSAN* m585/g585 88.3% identity in 231 aa overlap        10        20        30        40        50        60 m585.pepMKLFQRIFATFCAVIVCAIFVASFSFWLVQNTLAENQFNQRRTIETTLMGSIISAFRARG||||||||||||||||||||||||||||||||||||||||||||||||||||||||::|| g585MKLFQRIFATFCAVIVCAIFVASFSFWLVQNTLAENQFNQRRTIETTLMGSIISAFKTRG        10        20        30        40        50        60        70        80        90       100       110       120 m585.pepDAGAREILTEWKDSPVSSGVYVIQGDEKKDILNRYIDSYTIERARLFAAGHPHSNLVHIE| ||||||||||:|||||:||||||||||||||||||:|||||||||||::||||||:|| g585DNGAREILTEWKNSPVSSAVYVIQGDEKKDILNRYIDNYTIERARLFAANNPHSNLVRIE        70        80        90       100       110       120       130       140       150       160       170       180 m585.pepYDRFGEEYLFFTKDWDKLQARRLPSPLLIPGLPLAPIWHELIILSFIIIVGLLMAYILAG||||||||||| | ||: ||:||||||:||||||||||||:||||||||||||||||||| g585YDRFGEEYLFFIKGWDNHQAQRLPSPLFIPGLPLAPIWHEFIILSFIIIVGLLMAYILAG       130       140       150       160       170       180       190       200       210       220       230       240 m585.pepNIAKPIRILGNGMDRVANGELETRISQQVDDRDDELSHLAIQFDKMVEKLEKLVAKERHL|||||||||||||||||: ||| |: ||| ||||||: :|:||| |||||| g585NIAKPIRILGNGMDRVAERELEDRVCQQVRDRDDELADVAMQFDTMVEKLEX       190       200       210       220       230       250       260       270       280       290       300 m585.pepLHHVSHEMRSPLARMQAIVGLIQAQPQKQEQYLKRLEGELTRMDTLAGELLTLSRLETSNThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1807>:

a585.seq 1 ATGAAACTGT TCCAACGCAT CTTCGCCACA TTTTGCGCGG TTATCGTCTG 51TGCAATCTTT GTGGCGAGTT TTTCTTTCTG GCTGGTGCAG AACACCCTTG 101 CCGAAAACCAGTTCAACCAA CGCCGCACCA TCGAAACCAC TTTGATGGGC 151 AGCATCATTT CCGCATTCCGGGCACGCGGG GACGCGGGTG CGCGCGAAAT 201 CCTGACGGAA TGGAAAGACA GCCCCGTCTCATCGGGCGTG TACGTTATAC 251 AGGGCGACGA GAAAAAAGAT ATCCTGCACC GGTATATCGACAGCTACACC 301 ATCGAACGCG CCCGGCTTTT CGCCGCCGGA CACCCGCATT CCAACCTCGT351 CCATATCGAA TACGACCGCT TCGGCGAAGA ATACCTGTTC TTCACCAAAG 401ACTGGGACAA ACTCCAAGCC CGCCGCCTGC CCAGCCCCCT GTTGATCCCC 451 GGCCTGCCGCTCGCCCCGAT TTGGCACGAA CTCATCATAT TGTCCTTCAT 501 CATCATCGTC GGACTGCTGATGGCGTACAT CCTCGCCGGC AACATTGCCA 551 AACCCATCAG AATCTTAGGC AACGGCATGGACAGGGTGGC AAACGGAGAA 601 CTTGAAACCC GTATCTCCCA ACAGGTCGAC GACCGCGACGACGAATTGTC 651 CCATCTTGCC ATCCAATTCG ACAAAATGGT GGAAAAACTC GAAAAACTCG701 TTGCCAAAGA ACGCCACCTG CTCCATCACG TCTCCCATGA AATGCGTTCT 751CCCCTTGCGC GCATGCAGGC AATTGTCGGA CTGATTCAGG CGCAGCCCCA 801 AAAACAGGAGCAATATCTCA AACGGCTGGA AGGCGAACTG AACGGCATGG 851 ATACGCTGGC CGGGGAACTGTTAACCCTGT CCCGTCTCGA AACTTCCAAT 901 ATGGCTTTGG AAAAAGAAAG CCTGAAACTCCTGCCCTTCC TGGGCAACCT 951 GGTAGAAGAC AATCAAAGCA TTGCCCAGAA AAACGGACAAACGGTTACCC 1001 TGTCTGCCGA CGGAAAAATC CCCGAAAACA CAACCATCCT TGCCAACGAA1051 AGCTACCTGT ACCGCGCCTT CGACAACGTC ATCCGCAACG CCGTCAACTA 1101CAGTCCCGAA GGCAGCACCA TCCTGATCAA CATCGGACAA GACCACAAAC 1151 ACTGGATAATCGACGTTACC GACAACGGCC CCGGCGTGGA CGAAATGCAG 1201 CTCCCGCACA TCTTCACCGCTTTCTACCGT GCAGACTCCA GTGCCAACAA 1251 ACCCGGAACA GGACTGGGGC TTGCATTGACCCAACATATT ATTGAACAGC 1301 ACTGCGGCAA AATCATCGCC GAAAACATCA AACCGAACGGTCTGCGGATG 1351 CGCTTTATCC TGCCCAAGAA AAAAACCGGT TCCAAAACAG AAAAAAGTGC1401 GAACTGAThis corresponds to the amino acid sequence <SEQ ID 1808; ORF 585.a>:

a585.pep 1 MKLFQRIFAT FCAVIVCAIF VASFSFWLVQ NTLAENQFNQ RRTIETTLMG 51SIISAFRARG DAGAREILTE WKDSPVSSGV YVIQGDEKKD ILHRYIDSYT 101 IERARLFAAGHPHSNLVHIE YDRFGEEYLF FTKDWDKLQA RRLPSPLLIP 151 GLPLAPIWHELIILSFIIIV GLLMAYILAG NIAKPIRILG NGMDRVANGE 201 LETRISQQVD DRDDELSHLAIQFDKMVEKL EKLVAKERHL LHHVSHEMRS 251 PLARMQAIVG LIQAQPQKQE QYLKRLEGELTRMDTLAGEL LTLSRLETSN 301 MALEKESLKL LPFLGNLVED NQSIAQKNGQ TVTLSADGKIPENTTILANE 351 SYLYRAFDNV IRNAVNYSPE GSTILINIGQ DHKHWIIDVT DNGPGVDEMQ401 LPHIFTAFYR ADSSANKPGT GLGLALTQHI IEQHCGKIIA ENIKPNGLRM 451RFILPKKKTG SKTEKSAN* m585/a585 99.8% identity in 468 aa overlap        10        20        30        40        50        60 m585.pepMKLFQRIFATFCAVIVCAIFVASFSFWLVQNTLAENQFNQRRTIETTLMGSIISAFRARG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a585MKLFQRIFATFCAVIVCAIFVASFSFWLVQNTLAENQFNQRRTIETTLMGSIISAFRARG        10        20        30        40        50        60        70        80        90       100       110       120 m585.pepDAGAREILTEWKDSPVSSGVYVIQGDEKKDILNRYIDSYTIERARLFAAGHPHSNLVHIE||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||| a585DAGAREILTEWKDSPVSSGVYVIQGDEKKDILHRYIDSYTIERARLFAAGHPHSNLVHIE        70        80        90       100       110       120       130       140       150       160       170       180 m585.pepYDRFGEEYLFFTKDWDKLQARRLPSPLLIPGLPLAPIWHELIILSFIIIVGLLMAYILAG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a585YDRFGEEYLFFTKDWDKLQARRLPSPLLIPGLPLAPIWHELIILSFIIIVGLLMAYILAG       130       140       150       160       170       180       190       200       210       220       230       240 m585.pepNIAKPIRILGNGMDRVANGELETRISQQVDDRDDELSHLAIQFDKMVEKLEKLVAKERHL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a585NIAKPIRILGNGMDRVANGELETRISQQVDDRDDELSHLAIQFDKMVEKLEKLVAKERHL       190       200       210       220       230       240       250       260       270       280       290       300 m585.pepLHHVSHEMRSPLARMQAIVGLIQAQPQKQEQYLKRLEGELTRMDTLAGELLTLSRLETSN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a585LHHVSHEMRSPLARMQAIVGLIQAQPQKQEQYLKRLEGELTRMDTLAGELLTLSRLETSN       250       260       270       280       290       300       310       320       330       340       350       360 m585.pepMALEKESLKLLPFLGNLVEDNQSIAQKNGQTVTLSADGKIPENTTILANESYLYRAFDNV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a585MALEKESLKLLPFLGNLVEDNQSIAQKNGQTVILSADGKIPENTTILANESYLYRAFDNV       310       320       330       340       350       360       370       380       390       400       410       420 m585.pepIRNAVNYSPEGSTILINIGQDHKHWIIDVTDNGPGVDEMQLPHIFTAFYRADSSANKPGT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a585IRNAVNYSPEGSTILINIGQDHKHWIIDVIDNGPGVDEMQLPHIFTAFYRADSSANKPGT       370       380       390       400       410       420       430       440       450       460      469 m585.pepGLGLALTQHIIEQHCGKIIAENIKPNGLRMRFILPKKKTGSKTEKSANX||||||||||||||||||||||||||||||||||||||||||||||||| a585GLGLALTQHIIEQHCGKIIAENIKPNGLRMRFILPKKKTGSKTEKSANX       430       440       450       460The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1809>:

g586.seq.. 1 atggcagccc atctcgaaga acaacaagag ttagacaact ttaaatattt 51ttggaaaacc acgggcaaat ggctgtttgc cctgctgatt ttggcggcac 101 tcggctacttgggatacacg gtttaccaaa accgtgcggc ttcccaaaat 151 caggaagcgg cggcggtgctggcaaacatc gtggaaaagg cgcaaaacaa 201 agccccgcaa agcgaaatca atgccgaactgtccaaactc caacaaagct 251 acccccattc catttccgcc gcccaagcca cgctgatggcggcggcaacc 301 gaatttgacg cgcagcgtta cgatgttgcc gaaggtcatt tgaaatgggt351 gttgtccaac caaaaagaca gcctgattca ggcgttggcg gcgcagcgtc 401tgggcgttgt gttgttgcaa caaaaaaaat acgatgccgc gcttgccgca 451 ctcgacacgccggttgaggc ggacttcgcc cccctgctga tggaaactaa 501 aggcgatgtt tatgccgcacaggaaaaaag ccaggaagcc ttaaaaaact 551 acggacaggc tttggaaaaa atgcctcaagattctgtcgg tcgcgaattg 601 cttcaaatga aactcgattc gctgaaataaThis corresponds to the amino acid sequence <SEQ ID 1810; ORF 586.ng>:

g586.pep.. 1 MAAHLEEQQE LDNFKYFWKT TGKWLFALLI LAALGYLGYT VYQNRAASQN 51QEAAAVLANI VEKAQNKAPQ SEINAELSKL QQSYPHSISA AQATLMAAAT 101 EFDAQRYDVAEGHLKWVLSN QKDSLIQALA AQRLGVVLLQ QKKYDAALAA 151 LDTPVEADFA PLLMETKGDVYAAQEKSQEA LKNYGQALEK MPQDSVGREL 201 LQMKLDSLK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1811>:

m586.seq 1 ATGGCAGCCC ATCTCGAAGA ACAACAAGAG TTAGACAACT TTAAATATTT 51TTGGAAAACC ACGGGCAAAT GGCTGTTTGC CTTGCTGATT TTGGCGGCAC 101 TCGGCTACTTGGGATACACG GTTTACCAAA ACCGTAAAGT TTCCCAAAAT 151 CAGGAAGCGG CGGCGGTGCTGGCAAACATC GTAGAAAAGG CGCAAAGCAA 201 AGCCCCGCAA AGCGAAATCA ATGCCGAATTGACCAAACTC CAACAAAGCT 251 ACCCGCATTC CATTTCCGCC GCCCAAGCCA CACTGATGGCGGCGGCAACC 301 GAATTTGACG CGCAGCGTTA CGATGTTGCC GAAGGCCATT TGAAATGGGT351 GTTGTCCAAC CAAAAAGACA GCCTGATTCA AGCGTTGGCG GCGCAGCGTC 401TGGGCGTTGT GTTGTTGCAA CAAAAAAAAT ACGATGCCGC GCTTGCCGCG 451 CTCGATACGCCGGTTGAAGC GGACTTCGCC CCCCTGCTGA TGGAAACCAA 501 AGGCGATGTC TATGCCGCACAGGGAAAAAG CCAGGAAGCC TTAAAAAACT 551 ACGGACAGGC TTTAGAAAAA ATGCCTCAAGATTCTGTCGG TCGCGAATTG 601 GTTCAAATGA AACTTGATTC GCTGAAATAAThis corresponds to the amino acid sequence <SEQ ID 1812; ORF 586>:

m586.pep 1 MAAHLEEQQE LDNFKYFWKT TGKWLFALLI LAALGYLGYT VYQNRKVSQN 51QEAAAVLANI VEKAQSKAPQ SEINAELTKL QQSYPHSISA AQATLMAAAT 101 EFDAQRYDVAEGHLKWVLSN QKDSLIQALA AQRLGVVLLQ QKKYDAALAA 151 LDTPVEADFA PLLMETKGDVYAAQGKSQEA LKNYGQALEK MPQDSVGREL 201 VQMKLDSLK* m586/g586 97.1% identityin 209 aa overlap        10        20        30        40        50        60 m586.pepMAAHLEEQQELDNFKYFWKTTGKWLFALLILAALGYLGYLVYQNRKVSQNQEAAAVLANI||||||||||||||||||||||||||||||||||||||||||||| :||||||||||||| g586MAAHLEEQQELDNFKYFWKTTGKWLFALLILAALGYLGYLVYQNRAASQNQEAAAVLANI        10        20        30        40        50        60        70        80        90       100       110       120 m586.pepVEKAQSKAPQSEINAELTKLQQSYPHSISAAQATLMAAATEFDAQRYDVAEGHLKWVLSN|||||:|||||||||||:|||||||||||||||||||||||||||||||||||||||||| g586VEKAQNKAPQSEINAELSKLQQSYPHSISAAQATLMAAATEFDAQRYDVAEGHLKWVLSN        70        80        90       100       110       120       130       140       150       160       170       180 m586.pepQKDSLIQALAAQRLGVVLLQQKKYDAALAALDTPVEADFAPLLMETKGDVYAAQGKSQEA|||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||| g586QKDSLIQALAAQRLGVVLLQQKKYDAALAALDTPVEADFAPLLMETKGDVYAAQEKSQEA       130       140       150       160       170       180       190       200       210 m586.pep LKNYGQALEKMPQDSVGRELVQMKLDSLKX||||||||||||||||||||:||||||||| g586 LKNYGQALEKMPQDSVGRELLQMKLDSLKX       190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1813>:

a586.seq 1 ATGGCAGCCC ATTTGGAAGA ACAACAAGAG TTGGACAACT TTAAATATTT 51TTGGAAAACC ACGGGCAAAT GGCTGTTTGC CGTGCTGATT TTGGCGGCAC 101 TCGGCTACTTGGGATACACG GTTTACCAAA ACCGTGCGGC TTCCCAAAAT 151 CAGGAAGCGG CGGCGGTGCTGGCAAACATC GTGGAAAAGG CGCAAAACAA 201 AGCCCCGCAA AGCGAAATCA ATGCCGAATTGGCCAAGCTC CAACAAAGCT 251 ACCCCCATTC CATTTCCGCC GCCCAAGCCA CGCTGATGGCGGCAGCAACC 301 GAATTTGACG CGCAGCGTTA CGATGTTGCC GAAGGCCATT TGAAATGGGT351 ATTGTCCAAC CAAAAAGACA GCCTGATCCA GGCGTTGGCG GCGCAGCGTC 401TGGGCGTTGT GTTGTTGCAA CAAAAAAAAT ACGATGCCGC GCTTGCCGCA 451 CTCGACACGCCGGTTGAAGC GGACTTCGCC CCCCTGCTGA TGGAAACCAA 501 AGGCGATGTC TATGCCGCACAGGGAAAAAG CCAGGAAGCC TTAAAAAACT 551 ACGGACAGGC TTTAGAAAAA ATGCCTCAAGATTCTGTCGG TCGCGAATTG 601 GTTCAAATGA AACTTGATTC GCTGAAATAAThis corresponds to the amino acid sequence <SEQ ID 1814; ORF 586.a>:

a586.pep 1 MAAHLEEQQE LDNFKYFWKT TGKWLFAVLI LAALGYLGYT VYQNRAASQN 51QEAAAVLANI VEKAQNKAPQ SEINAELAKL QQSYPHSISA AQATLMAAAT 101 EFDAQRYDVAEGHLKWVLSN QKDSLIQALA AQRLGVVLLQ QKKYDAALAA 151 LDTPVEADFA PLLMETKGDVYAAQGKSQEA LKNYGQALEK MPQDSVGREL 201 VQMKLDSLK* m586/a586 97.6% identityin 209 aa overlap        10        20        30        40        50        60 m586.pepMAAHLEEQQELDNFKYFWKTTGKWLFALLILAALGYLGYTVYQNRKVSQNQEAAAVLANI|||||||||||||||||||||||||||:||||||||||||||||| :||||||||||||| a586MAAHLEEQQELDNFKYFWKTTGKWLFAVLILAALGYLGYTVYQNRAASQNQEAAAVLANI        10        20        30        40        50        60        70        80        90       100       110       120 m586.pepVEKAQSKAPQSEINAELTKLQQSYPHSISAAQATLMAAATEFDAQRYDVAEGHLKWVLSN|||||:|||||||||||:|||||||||||||||||||||||||||||||||||||||||| a586VEKAQNKAPQSEINAELAKLQQSYPHSISAAQATLMAAATEFDAQRYDVAEGHLKWVLSN        70        80        90       100       110       120       130       140       150       160       170       180 m586.pepQKDSLIQALAAQRLGVVLLQQKKYDAALAALDTPVEADFAPLLMETKGDVYAAQGKSQEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a586QKDSLIQALAAQRLGVVLLQQKKYDAALAALDTPVEADFAPLLMETKGDVYAAQGKSQEA       130       140       150       160       170       180       190       200       210 m586.pep LKNYGQALEKMPQDSVGRELVQMKLDSLKX|||||||||||||||||||||||||||||| a586 LKNYGQALEKMPQDSVGRELVQMKLDSLKX       190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1815>:

g587.seq.. 1 atgaaacgta tctttttgcc cgccttgccc gccatcctgc ctttatccgc 51ttatgccgac ctgcccttga cgattgaaga cataatgacc gacaagggaa 101 aatggaaactggaaacttcc cttacctatc tgaatagcga aaacagccgc 151 gccgcacttg ccgcaccggtttacattcaa accggcgcaa cctcgtttat 201 ccccattccg accgaaattc aagaaaacggcagcaatacc gatatgctcg 251 ccggcacgct cggtttgcgc tacggactga ccggcaataccgacatttac 301 ggcagcggca gctatctgtg gcacgaagaa cgcaaactcg acggcaacgg351 caaaacccgc aacaaacgga tgtccgacat atccgccggc atcagccaca 401ccttccttaa agacggcaaa aaccccgccc taatcagctt tcttgaaagc 451 acggtttacgaaaaatcgcg caacaaagcc tcgttaatca aaaaaagggg 501 gctttgcccc ttttataacttaaggataaa ttatgaatat taaThis corresponds to the amino acid sequence <SEQ ID 1816; ORF 587.ng>:

g587.pep.. 1 MKRIFLPALP AILPLSAYAD LPLTIEDIMT DKGKWKLETS LTYLNSENSR 51AALAAPVYIQ TGATSFIPIP TEIQENGSNT DMLAGTLGLR YGLTGNTDIY 101 GSGSYLWHEERKLDGNGKTR NKRMSDISAG ISHTFLKDGK NPALISFLES 151 TVYEKSRNKA SLIKKRGLCPFYNLRINYEY *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1817>:

m587.seq.. 1 ATGAAGCGCA TCTTTTTGCC CGCCTTGCCC GCCATCCTGC CTTTATCCAC 51TTATGCCGAC CTGCCCTTGA CGATTGAAGA CATAATGACC GACAAGGGAA 101 AATGGAAACTGGAAACTTCC CTTACCTACC TGAACAGCGA AAACAACCGC 151 GCCGAACTTG CCGCACCGGTTTACATTCAA ACCGGCGCAA CCTCGTTTAT 201 CCCCATTCCG ACCGAAATCC AAGAAAACGGCAGCAATACC GATATGCTCG 251 TCGGCACGCT CGGTTTGCGC TACGGACTGA CCGGGAATACCGACATTTAC 301 GGCAGCGGCA GCTATCTGTG GCACGAAGAA CGCAAACTCG ACGGCAACAG351 CAAAACCCGC AACAAACGGA TGTCCGACGT ATCCCTCGGC ATCAGCCACA 401CTTTCCTTAA AGACGACAAA AACCCCGCCC TAATCAGCTT TCTTGAAAGC 451 ACGGTTTACGAAAAATCGCG CAACAAAGCC TCGTCGGGAA AATCCTGGCT 501 CATCGGCGCC ACCACCTACAAAGCCATAGA TCCGATTGTC CTTTCCTTCA 551 CCGCCGCCTA CCGCATCAAC GGCAGCAAAACCCTTTCAGA CGGCATCCGC 601 TACAAATCGG GCAACTACCT GCTGCTCAAC CCCAACATCTCATTTGCTGC 651 CAACGACAGA ATCAGCCTGA CCGGAGGCAT CCAATGGCTG GGCAGGCAGC701 CCGACCGGAC GGACGGCAAA CGGGAATCCT CCAGAAACAC ATCCACCTAC 751GCCCATTTCG GCGCAGGTTT CGGTTTCACC AAAACCACGG CTTTAAACGC 801 ATCCGCACGTTTCAACGTTT CAGGGCAAAG CAGTTCCGAA CTGAAATTTG 851 GCGTACAGCA TACATTTTAAThis corresponds to the amino acid sequence <SEQ ID 1818; ORF 587>:

m587.pep.. 1 MKRIFLPALP AILPLSTYAD LPLTIEDIMT DKGKWKLETS LTYLNSENNR 51AELAAPVYIQ TGATSFIPIP TEIQENGSNT DMLVGTLGLR YGLTGNTDIY 101GSGSYLWHEE RKLDGNSKTR NKRMSDVSLG ISHTFLKDDK NPALISFLES 151TVYEKSRNKA SSGKSWLIGA TTYKAIDPIV LSLTAAYRIN GSKTLSDGIR 201YKSGNYLLLN PNISFAANDR ISLTGGIQWL GRQPDRTDGK RESSRNTSTY 251AHFGAGFGFT KTTALNASAR FNVSGQSSSE LKFGVQHTF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m587/g587 95.0% identity in 161 aa overlap        10        20        30        40        50        60 m587.pepMKRIFLPALPAILPLSTYADLPLTIEDIMTDKGKWKLETSLTYLNSENNRAELAAPVYIQ||||||||||||||||:|||||||||||||||||||||||||||||||:|| |||||||| g587MKRIFLPALPAILPLSAYADLPLTIEDIMTDKGKWKLETSLTYLNSENSRAALAAPVYIQ        10        20        30        40        50        60        70        80        90       100       110       120 m587.pepTGATSFIPIPTEIQENGSNTDMLVGTLGLRYGLTGNTDIYGSGSYLWHEERKLDGNSKTR|||||||||||||||||||||||:||||||||||||||||||||||||||||||||:||| g587TGATSFIPIPTEIQENGSNTDMLAGTLGLRYGLTGNTDIYGSGSYLWHEERKLDGNGKTR        70        80        90       100       110       120       130       140       150       160       170       180 m587.pepNKRMSDVSLGISHTFLKDDKNPALISFLESTVYEKSRNKASSGKSWLIGATTYKAIDPIV ||||||:|||||||||| |||||||||||||||||||||| g587NKRMSDISAGISHTFLKDGKNPALISFLESTVYEKSRNKASLIKKRGLCPFYNLRINYEY       130       140       150       160       170       180       190       200       210       220       230       240 m587.pepLSLTAAYRINGSKTLSDGIRYKSGNYLLLNPNISFAANDRISLTGGIQWLGRQPDRTDGK g587 XThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1819>:

a587.seq 1 ATGAAGCGCA TCTTTTTGCC CGCCTTGCCC GCCATCCTGC CTTTATCCGC 51TTATGCCGAC CTGCCCTTGA CGATTGAAGA CATAATGACC GACAAGGGCA 101AATGGAAACT GGAAACTTCC CTTACCTACC TGAACAGCGA AAACAACCGC 151GCCGAACTTG CCGCACCGGT TTACATCCAA ACCGGCGCAA CCTCGTTTAT 201CCCCATTCCG ACCGAAATCC AAGAAAACGG CAGCAATACC GATATGCTCG 251TTGGCACGCT CGGTTTGCGC TACGGACTGA CCGGGAATAC CGACATTTAC 301GGCAGCGGCA GCTATCTGTG GCACGAAGAA CGCAAACTCG ACGGCAACGG 351CAAAACCCGA AACAAACGGA TGTCCGACGT ATCCCTCGGC ATCAGCCACA 401CCTTCCTTAA AGACGACAAA AACCCCGCCC TAATCAGCTT TCTTGAAAGC 451ACGGTTTACG AAAAATCGCG CAACAAAGCC TCGTCGGGAA AATCCTGGCT 501CATCGGCGCC ACCACCTACA AAGCCATCGA CCCCGTCGTC CTCTCATTGA 551CCGCTGCCTA CCGTATCAAC GGCAGCAAAA CCCTTTCAAG CAACACCAAA 601TACAAAGCAG GCAATTACTG GATGCTGAAT CCCAATATAT CCTTCGCCGC 651CAACGACAGA ATCAGCCTCA CGGGCGGCAT CCAATGGCTG GGCAAGCAGC 701CCGACCGTCT GGACGGCAAA AAAGAATCCG CAAGAAACAC ATCCACCTAT 751GCCCATTTCG GCGCAGGTTT CGGTTTCACC AAAACCACGG CTTTAAACGC 801ATCCGCACGT TTCAACGTTT CAGGGCAAAG CAGTTCCGAA CTGAAATTTG 851GCGTACAGCA TACGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 1820; ORF 587.a>:

a587.pep 1 MKRIFLPALP AILPLSAYAD LPLTIEDIMT DKGKWKLETS LTYLNSENNR 51AELAAPVYIQ TGATSFIPIP TEIQENGSNT DMLVGTLGLR YGLTGNTDIY 101GSGSYLWHEE RKLDGNGKTR NKRMSDVSLG ISHTFLKDDK NPALISFLES 151TVYEKSRNKA SSGKSWLIGA TTYKAIDPVV LSLTAAYRIN GSKTLSSNTK 201YKAGNYWMLN PNISFAANDR ISLTGGIQWL GKQPDRLDGK KESARNTSTY 251AHFGAGFGFT KTTALNASAR FNVSGQSSSE LKFGVQHTF* m587/a58795.2% identity in 289 aa overlap        10        20        30        40        50        60 m587.pepMKRIFLPALPAILPLSTYADLPLTIEDIMTDKGKWKLETSLTYLNSENNRAELAAPVYIQ||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||| a587MKRIFLPALPAILPLSAYADLPLTIEDIMTDKGKWKLETSLTYLNSENNRAELAAPVYIQ        10        20        30        40        50        60        70        80        90       100       110       120 m587.pepTGATSFIPIPTEIQENGSNTDMLVGTLGLRYGLTGNTDIYGSGSYLWHEERKLDGNSKTR||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||| a587TGATSFIPIPTEIQENGSNTDMLVGTLGLRYGLTGNTDIYGSGSYLWHEERKLDGNGKTR        70        80        90       100       110       120       130       140       150       160       170       180 m587.pepNKRMSDVSLGISHTFLKDDKNPALISFLESTVYEKSRNKASSGKSWLIGATTYKAIDPIV||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:| a587NKRMSDVSLGISHTFLKDDKNPALISFLESTVYEKSRNKASSGKSWLIGATTYKAIDPVV       130       140       150       160       170       180       190       200       210       220       230       240 m587.pepLSLTAAYRINGSKTLSDGIRYKSGNYLLLNPNISFAANDRISLTGGIQWLGRQPDRTDGK||||||||||||||||:: :||:||| :|||||||||||||||||||||||:|||| ||| a587LSLTAAYRINGSKTLSSNTKYKAGNYWMLNPNISFAANDRISLTGGIQWLGKQPDRLDGK       190       200       210       220       230       240       250       260       270       280       290 m587.pepRESSRNTSTYAHFGAGFGFTKTTALNASARFNVSGQSSSELKFGVQHTFX:||:|||||||||||||||||||||||||||||||||||||||||||||| a587KESARNTSTYAHFGAGFGFTKTTALNASARFNVSGQSSSELKFGVQHTFX       250       260       270       280       290The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1821>:

g588.seq 1 atgcttaaac atctcgcatt cctactgccc gccatgatgt tcgccctccc 51cgcccagacc gccgtcctaa gcccctatca ggaaaccggc tgcacctacg 101aaggcgggat cggaaaagac gggcttcctt caggcaaagg catatggcgt 151tgccgggatg ggcgcggtta taccggttca ttcaaaaacg gcaaattcga 201cgggcaaggc gtttataccg ttgccgccgg ccgcgaagta tttctcgagc 251cgttcaattc cgacagtacc aaattccgca atatggcatt gtcgggcacg 301ttcaaacaag gcttggcaca cggcaggttc gccgcctcgc aaaacggcga 351aaccctcttt tattatgaaa tgcgaacacg gcatgattaaThis corresponds to the amino acid sequence <SEQ ID 1822; ORF 588.ng>:

g588.pep.. 1 MLKHLAFLLP AMMFALPAQT AVLSPYQETG CTYEGGIGKD GLPSGKGIWR 51CRDGRGYTGS FKNGKFDGQG VYTVAAGREV FLEPFNSDST KFRNMALSGT 101FKQGLAHGRF AASQNGETLF YYEMRTRHD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1823>:

m588.seq.. 1 ATGCTTAAAC ATCTCGCATT CCTACTGCCC GCCATGATGT TCGCCCTCCC 51CACTTCGGCC GCCGTCCTGA CTTCCTATCA AGAACCAGGC TGCACCTACG 101ACGGCAATGT CGGCAAAGAC GGTAAACCCG CCGGCAAAGG CACATGGCGC 151TGCCAAGACG GGCGCAACTA TACCGGTTCG TTTAAAAACG GCAAATTCGA 201CGGGCAAGGC GTTTATACCG TTGCCGCCAA CCGCGAAATA TTTATCGAAC 251CGTTCAATTC CGACAGTACC AAATTCCGCA ACATGGTACT CTCGGGCACG 301TTCAAAAAAG GCTTGGCACA CGGCAGATTT ACCGTCTCGC AAAACGGCGA 351AACCCTCTTC ATTATGAAAT GCGAAAACGG CATGATTAAA GAAGTGAAAC 401TGCCCAAAAA CAAATAAThis corresponds to the amino acid sequence <SEQ ID 1824; ORF 588>:

m588.pep.. 1 MLKHLAFLLP AMMFALPTSA AVLTSYQEPG CTYDGNVGKD GKPAGKGTWR 51CQDGRNYTGS FKNGKFDGQG VYTVAANREI FIEPFNSDST KFRNMVLSGT 101FKKGLAHGRF TVSQNGETLF IMKCENGMIK EVKLPKNK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m588/g588 82.5% identity in 120 aa overlap        10        20        30        40        50        60 m588.pepMLKHLAFLLPAMMFALPTSAAVLTSYQEPGCTYDGNVGKDGKPAGKGTWRCQDGRNYTGS|||||||||||||||||:::|||: ||| ||||:|::|||| |:||| |||:|||:|||| g588MLKHLAFLLPAMMFALPAQTAVLSPYQETGCTYEGGIGKDGLPSGKGIWRCRDGRGYTGS        10        20        30        40        50        60        70        80        90       100       110       120 m588.pepFKNGKFDGQGVYTVAANREIFIEPFNSDSTKFRNMVLSGTFKKGLAHGRFTVSQNGETLF||||||||||||||||:||:|:|||||||||||||:||||||:|||||||::|||||||| g588FKNGKFDGQGVYTVAAGREVFLEPFNSDSTKFRNMALSGTFKQGLAHGRFAASQNGETLF        70        80        90       100       110       120       130      139 m588.pep IMKCENGMIKEVKLPKNKX g588 YYEMRTRHDX       130The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1825>:

a588.seq 1 ATGCTTAAAC ATCTCGCATT CCTACTGCCC GCCATGATGT TCGCCCTCCC 51CGCCGCGTCC GCCGTTCTGA CTTCCTATCA AGAACCCGGC TGCACCTACG 101AAGGCGATGT CGGCAAAGAC GGTAAACCCG CCGGCAAAGG CACATGGCGC 151TGCCAAGACG GGCGCAACTA TACCGGTTCG TTTAAAAATG GCAAATTCGA 201CGGACAAGGC GTTTATACCG TTGCCGCCAA CCGCGAAATA TTTATCGAAC 251CGTTCAATTC CGACAGTACC AAATTCCGCA ACATGGTACT CTCGGGCACA 301TTCAAAAAAG GCTTGGCACA CGGCAGATTT ACCGTCTCGC AAAACGGCGA 351AACCCTCTTC ATTATGAAAT GCGAAAACGG CATGATTAAA GAAGTGAAGC 401TGCCCAAAAA CAAATAAThis corresponds to the amino acid sequence <SEQ ID 1826; ORF 588.a>:

a588.pep 1 MLKHLAFLLP AMMFALPAAS AVLTSYQEPG CTYEGDVGKD GKPAGKGTWR 51CQDGRNYTGS FKNGKFDGQG VYTVAANREI FIEPFNSDST KFRNMVLSGT 101FKKGLAHGRF TVSQNGETLF IMKCENGMIK EVKLPKNK* m588/a58896.4% identity in 138 aa overlap        10        20        30        40        50        60 m588.pepMLKHLAFLLPAMMFALPTSAAVLTSYQEPGCTYDGNVGKDGKPAGKGTWRCQDGRNYTGS|||||||||||||||||:::|||||||||||||:|:|||||||||||||||||||||||| a588MLKHLAFLLPAMMFALPAASAVLTSYQEPGCTYEGDVGKDGKPAGKGTWRCQDGRNYTGS        10        20        30        40        50        60        70        80        90       100       110       120 m588.pepFKNGKFDGQGVYTVAANREIFIEPFNSDSTKFRNMVLSGTFKKGLAHGRFTVSQNGETLF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a588FKNGKFDGQGVYTVAANREIFIEPFNSDSTKFRNMVLSGTFKKGLAHGRFTVSQNGETLF        70        80        90       100       110       120       130      139 m588.pep IMKCENGMIKEVKLPKNKX |||||||||||||||||||a588 IMKCENGMIKEVKLPKNKX        130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1827>:

g589.seq.. 1 atgcaacaaa aaatccgttt ccaaatcgag gcgatgacct gtcaggcatg 51tgcttcgcgc attgaaaaag tgttgaacaa aaaagatttt gtcgaatcgg 101cgggagtgaa ctttgccagt gaggaagcgc aggttacgtt tgacggcagc 151aaaacctcgg ttgccgacat tgccaaaatc attgagaaaa ccggttacgg 201cgcgaaggaa aaaacggaag atacattgcc gcaacctgaa gcagaacacc 251atatcggctg gcggttgtgg cttttgctga ccatcaatat cccgttcctt 301atcggtatgg tagggatgat gctaaaaggg ctgaattgga cacggcacga 351ttggatgatt ccgcctgtat ggcagtttgt actggcaagc atagtgcaac 401tttggctggc aatcccgttt tacaaaagcg cgtgggcaag cattaaaggc 451gggctggcga atatggacgt actcgttacc atcggcacgg tgtcgattta 501cctgtattcc gtttatatgc tgtttttcag ttcgcatgcg gcgcacggta 551tggcgcatgt gtattttgaa gcgggcgtga tggtgatcgg ttttgtgtcg 601ctgggtaagt ttttggaaca ccgcaccaaa aaatccagcc tgaacagctt 651gggcttactg ctaaaactca cgccgaccca agtcaacgtg caacgcaacg 701gcgaatggaa acaactgccc atcgaccaag tgcaaatcgg cgaccttatc 751cgcaccaacc acggcgaacg catcgctgcc gacggcatta tcgaaagcgg 801cagcggttgg gcggacgaaa gccaccttac cggcgaatcc aatcccgaag 851agaaaaaggc gggcggcaaa gtgttggcgg gcgcgctgat gaccgaaggc 901agcgtggtgt accgcgccgc gcagctcggc agccaaaccc tgctcggcga 951catgatgaac gcgctctctg aagcacaagg cagtaaagca ccgattgcgc 1001gcgtggccga taaagcggcg gcggtatttg tgccaactgt cgtgggcatc 1051gcgcttctga cttttatcgt tgcttggctg attaagggcg attggacggt 1101cgcactgatg cacgccgttg ccgttttggt gattgcctgc ccgtgcgcgc 1151tcggtctggc gacccctgcc gcgattatgg tcggcatggg caaagcggtg 1201aaacacggca tttggtttaa agacgcggcg gcaatggagg aagcagccca 1251cgtcgatgcc gtcgtattgg acaaaaccgg tacgctgacc gaaggcaggc 1301cgcaggttgc cgccgtttat tacgttcccg acagcggctt tgacgaagac 1351gctttgtacc gcatcgccgc cgccgtcgag caaaacgccg cccacccgct 1401cgcccgcgcc atcgtctccg ccgcacaagc gcgcggtttg gagattcccg 1451ctgcacaaaa tgcgcaaacc gttgtcggag caggcattac cgccgaagtg 1501gaaggcgtgg gtttggtgaa atcaggcaaa gccgaatttg ccgaactgac 1551cttgccgaag ttttcagacg gcgtttggga aatcgccagt gcggttaccg 1601tatctgtaaa cggcaaaccg atcggcgcat tcgcactctc cgacgcgttg 1651aaagccgata ccgccgaagc cataggccgt ctgaaaaaac acaatatcga 1701tgtctatatt atgagcggcg ataaccaaag tacggtcgaa tacgtcgcca 1751aacaactggg catcgcacac gccttcggta atatgagtcc gtgcgacaaa 1801gccgccgaag tgcagaaact caaagccgcc ggcaaaaccg tggcgatggt 1851cggcgacggc atcaacgacg cgcccgcgct tgccgccgcc aacgtcagct 1901tcgccatgaa aggcggtgcg gacgttgccg aacacaccgc ctccgccacg 1951ctgatgcagc attcggtcaa tcagctcgcc gatgccctgc tgatatcgca 2001ggcaacgttg gaaaacatca agcaaaacct atttttcgcc ttcttctaca 2051atatattggg cattccgctc gccgcgctcg gctttttaaa tcccgtcata 2101gcaggcgcgg caatggcggc aagctcggtt tcggtattgg gcaatgccct 2151gcgcctgaaa tgggtaaaaa tcgattgaThis corresponds to the amino acid sequence <SEQ ID 1828; ORF 589.ng>:

g589.pep.. 1 MQQKIRFQIE AMTCQACASR IEKVLNKKDF VESAGVNFAS EEAQVTFDGS 51KTSVADIAKI IEKTGYGAKE KTEDTLPQPE AEHHIGWRLW LLLTINIPFL 101IGMVGMMLKG LNWTRHDWMI PPVWQFVLAS IVQLWLAIPF YKSAWASIKG 151GLANMDVLVT IGTVSIYLYS VYMLFFSSHA AHGMAHVYFE AGVMVIGFVS 201LGKFLEHRTK KSSLNSLGLL LKLTPTQVNV QRNGEWKQLP IDQVQIGDLI 251RTNHGERIAA DGIIESGSGW ADESHLTGES NPEEKKAGGK VLAGALMTEG 301SVVYRAAQLG SQTLLGDMMN ALSEAQGSKA PIARVADKAA AVFVPTVVGI 351ALLTFIVAWL IKGDWTVALM HAVAVLVIAC PCALGLATPA AIMVGMGKAV 401KHGIWFKDAA AMEEAAHVDA VVLDKTGTLT EGRPQVAAVY YVPDSGFDED 451ALYRIAAAVE QNAAHPLARA IVSAAQARGL EIPAAQNAQT VVGAGITAEV 501EGVGLVKSGK AEFAELTLPK FSDGVWEIAS AVTVSVNGKP IGAFALSDAL 551KADTAEAIGR LKKHNIDVYI MSGDNQSTVE YVAKQLGIAH AFGNMSPCDK 601AAEVQKLKAA GKTVAMVGDG INDAPALAAA NVSFAMKGGA DVAEHTASAT 651LMQHSVNQLA DALLISQATL ENIKQNLFFA FFYNILGIPL AALGFLNPVI 701AGAAMAASSV SVLGNALRLK WVKID*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1829>:

m589.seq.. 1 ATGCAACAAA AAATCCGTTT CCAAATCGAA GGCATGACCT GCCAGGCCTG 51CGCTTCGCGC ATTGAAAAAG TGTTGAACAA AAAAGATTTT GTCGAATCGG 101CGGGGGTAAA CTTCGCCAGC GAAGAGGCGC AGGTAGTGTT TGACGACAGC 151AAAACCTCAG TAGCCGACAT TGCCAAAATC ATTGAGAAAA CCGGTTACGG 201CGCGAAGGAA AAAACGGAAG ATACATTGCC GCAACCCGAA GCAGAACACC 251ATATCGGCTG GCGGCTGTGG CTGCTGTTCA CCATCAACGT CCCGTTCCTT 301ATCGGCATGG CGGGGATGAT GATCGGCAGA CACGATTGGA TGATTCCGCC 351GTTGTGGCAG TTCGCATTGG CAAGCGTGGT GCAGCTTTGG CTGGCAATCC 401CGTTTTACAA AAGCGCGTGG GCGAGCATTA AGGGCGGACT GGCGAATATG 451GACGTGCTGG TTACCATCGG CACGGTCTCG ATTTACCTGT ATTCCGTCTA 501TATGCTGTTT TTCAGCCCGC ACGCGGCGTA CGGTATGGCG CATGTGTATT 551TTGAAGTGGG CGTGATGGTG ATCGGTTTTG TGTCACTGGG TAAATTTTTG 601GAACACCGTA CCAAAAAATC CAGCCTCAAC AGCTTGGGCT TGCTGCTCAA 651ACTTACACCA ACCCAAGTCA ACGTGCAACG CAACGGCGAA TGGAAACAGC 701TTCCCATCGA CCAAGTGCAA ATCGGCGACC TTATCCGCGC CAACCACGGC 751GAACGCATTG CCGCAGACGG CATCATTGAA AGCGGCAGCG GTTGGGCGGA 801CGAGAGCCAT CTTACCGGCG AATCCAATCC TGAAGAAAAA AAGGCGGGCG 851GCAAAGTGTT GGCGGGCGCG TTAATGACCG AAGGCAGTGT GGTGTACCGC 901GCCACGCAGC TCGGCAGCCA AACCCAGCTC GGCGACATGA TGAACGCGCT 951CTCTGAAGCA CAAGGCAGTA AAGCACCGAT TGCGCGCGTA GCCGATAAAG 1001CGGCTGCGGT ATTCGTGCCT GCCGTCGTGG GCATTGCGTT GTTGACTTTT 1051ATTGTTACTT GGCTGATTAA GGGCGATTGG ACGGTTGCGC TGATGCACGC 1101CGTCGCCGTT TTGGTGATTG CCTGCCCGTG CGCGCTGGGT CTGGCAACCC 1151CTGCCGCGAT TATGGTCGGT ATGGGCAAAG CGGTTAAACA CGGTATTTGG 1201TTTAAAGACG CGGCAGCAAT GGAGGAAGCC GCCCACGTCG ATGCCGTCGT 1251GTTGGACAAA ACCGGTACGC TGACCGAAGG CAGCCCGCAG GTTGCCGCCG 1301TTTATTGCGT TCCCGACAGC GGCTTTGACG AAGACGCTTT GTACCGCATC 1351GCCGCCGCCG TCGAACAAAA CGCCGCCCAT CCGCTCGCCC GTGCCATCGT 1401CTCCGCCGCC CAAGCGCGCG GTTTGGACAT TCCCGCCGCA CAAAACGCAC 1451AAACCGTTGT CGGCGCAGGC ATTACCGCCG AAGTGGAAGG CGTGGGTTTG 1501GTGAAAGCAG GCAAAGCCGA ATTTGCCGAA CTGGCCTTGC CGAAGTTTTT 1551AGACGGCGTT TGGGATATTG CAAGCATTGT TGCGGTCTCA GTCGATAACA 1601AACCCATCGG CGCATTCGCA CTTGCCGACG CGTTGAAAGC CGATACCGCC 1651GAAGCCATAG GCCGTCTGAA AAAACACAAT ATCGATGTCT ATATTATGAG 1701CGGCGACAAC CAAGGCACGG TCGAATACGT CGCCAAACAA CTGGGCATCG 1751CACACGCCTT CGGCAACATG AGTCCGCGCG ATAAAGCTGC CGAAGTGCAA 1801AAACTCAAAG CCGCCGGCAA AACCGTGGCG ATGGTCGGCG ACGGCATCAA 1851CGACGCGCCC GCGCTTGCCG CCGCTAACGT CAGCTTCGCC ATGAAAGGCG 1901GAGCGGACGT TGCCGAACAT ACCGCATCCG CCACGCTGAT GCAGCATTCG 1951GTCAACCAAC TCGCCGATGC TCTGCTGGTG TCGCAAGCCA CTTTGAAAAA 2001CATCAAGCAA AACCTGTTTT TCGCCTTCTT CTACAATATT TTGGGCATTC 2051CTCTCGCCGC GCTTGGCTTT TTAAATCCCG TCATCGCTGG CGCGGCAATG 2101GCGGCAAGCT CGGTTTCCGT GTTGAGCAAT GCCTTGCGCC TGAAACGGGT 2151AAAAATCGAT TAGThis corresponds to the amino acid sequence <SEQ ID 1830; ORF 589>:

m589.pep.. 1 MQQKIRFQIE GMTCQACASR IEKVLNKKDF VESAGVNFAS EEAQVVFDDS 51KTSVADIAKI IEKTGYGAKE KTEDTLPQPE AEHHIGWRLW LLFTINVPFL 101IGMAGMMIGR HDWMIPPLWQ FALASVVQLW LAIPFYKSAW ASIKGGLANM 151DVLVTIGTVS IYLYSVYMLF FSPHAAYGMA HVYFEVGVMV IGFVSLGKFL 201EHRTKKSSLN SLGLLLKLTP TQVNVQRNGE WKQLPIDQVQ IGDLIRANHG 251ERIAADGIIE SGSGWADESH LTGESNPEEK KAGGKVLAGA LMTEGSVVYR 301ATQLGSQTQL GDMMNALSEA QGSKAPIARV ADKAAAVFVP AVVGIALLTF 351IVTWLIKGDW TVALMHAVAV LVIACPCALG LATPAAIMVG MGKAVKHGIW 401FKDAAAMEEA AHVDAVVLDK TGTLTEGSPQ VAAVYCVPDS GFDEDALYRI 451AAAVEQNAAH PLARAIVSAA QARGLDIPAA QNAQTVVGAG ITAEVEGVGL 501VKAGKAEFAE LALPKFLDGV WDIASIVAVS VDNKPIGAFA LADALKADTA 551EAIGRLKKHN IDVYIMSGDN QGTVEYVAKQ LGIAHAFGNM SPRDKAAEVQ 601KLKAAGKTVA MVGDGINDAP ALAAANVSFA MKGGADVAEH TASATLMQHS 651VNQLADALLV SQATLKNIKQ NLFFAFFYNI LGIPLAALGF LNPVIAGAAM 701AASSVSVLSN ALRLKRVKID *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m589/g589 94.2% identity in 725 aa overlap        10        20        30        40        50        60 m589.pepMQQKIRFQIEGMTCQACASRIEKVLNKKDFVESAGVNFASEEAQVVFDDSKTSVADIAKI||||||||||:||||||||||||||||||||||||||||||||||:|| ||||||||||| g589MQQKIRFQIEAMTCQACASRIEKVLNKKDFVESAGVNFASEEAQVTFDGSKTSVADIAKI        10        20        30        40        50        60        70        80        90       100      1     110 m589.pepIEKTGYGAKEKTEDTLPQPEAEHHIGWRLWLLFTINVPFLIGMAGMMIG-----RHDWMI||||||||||||||||||||||||||||||||:|||:||||||:|||:      |||||| g589IEKTGYGAKEKTEDTLPQPEAEHHIGWRLWLLLTINIPFLIGMVGMMLKGLNWTRHDWMI        70        80        90       100       110       120  120       130       140       150       160       170 m589.pepPPLWQFALASVVQLWLAIPFYKSAWASIKGGLANMDVLVTIGTVSIYLYSVYMLFFSPHA||:|||:|||:|||||||||||||||||||||||||||||||||||||||||||||| || g589PPVWQFVLASIVQLWLAIPFYKSAWASIKGGLANMDVLVTIGTVSIYLYSVYMLFFSSHA       130       140       150       160       170       180  180       190       200       210       220       230 m589.pepAYGMAHVYFEVGVMVIGFVSLGKFLEHRTKKSSLNSLGLLLKLTPTQVNVQRNGEWKQLP|:||||||||:||||||||||||||||||||||||||||||||||||||||||||||||| g589AHGMAHVYFEAGVMVIGFVSLGKFLEHRTKKSSLNSLGLLLKLTPTQVNVQRNGEWKQLP       190       200       210       220       230       240  240       250       260       270       280       290 m589.pepIDQVQIGDLIRANHGERIAADGIIESGSGWADESHLTGESNPEEKKAGGKVLAGALMTEG|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||| g589IDQVQIGDLIRTNHGERIAADGIIESGSGWADESHLTGESNPEEKKAGGKVLAGALMTEG       250       260       270       280       290       300  300       310       320       330       340       350 m589.pepSVVYRATQLGSQTQLGDMMNALSEAQGSKAPIARVADKAAAVFVPAVVGIALLTFIVTWL||||||:|||||| ||||||||||||||| |||||||||||||||:|||||||||||:|| g589SVVYRAAQLGSQTLLGDMMNALSEAQGSKAPIARVADKAAAVFVPTVVGIALLTFIVAWL       310       320       330       340       350       360  360       370       380       390       400       410 m589.pepIKGDWTVALMHAVAVLVIACPCALGLATPAAIMVGMGKAVKHGIWFKDAAAMEEAAHVDA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g589IKGDWTVALMHAVAVLVIACPCALGLATPAAIMVGMGKAVKHGIWFKDAAAMEEAAHVDA       370       380       390       400       410       420  420       430       440       450       460       470 m589.pepVVLDKTGTLTEGSPQVAAVYCVPDSGFDEDALYRIAAAVEQNAAHPLARAIVSAAQARGL|||||||||||| ||||||| ||||||||||||||||||||||||||||||||||||||| g589VVLDKTGTLTEGRPQVAAVYYVPDSGFDEDALYRIAAAVEQNAAHPLARAIVSAAQARGL       430       440       450       460       470       480  480       490       500       510       520       530 m589.pepDIPAAQNAQTVVGAGITAEVEGVGLVKAGKAEFAELALPKFLDGVWDIASIVAVSVDNKP:||||||||||||||||||||||||||:||||||||:|||| ||||:||| |:|||::|| g589EIPAAQNAQTVVGAGITAEVEGVGLVKSGKAEFAELTLPKFSDGVWEIASAVTVSVNGKP       490       500       510       520       530       540  540       550       560       570       580       590 m589.pepIGAFALADALKADTAEAIGRLKKHNIDVYIMSGDNQGTVEYVAKQLGIAHAFGNMSPRDK||||||:|||||||||||||||||||||||||||||:|||||||||||||||||||| || g589IGAFALSDALKADTAEAIGRLKKHNIDVYIMSGDNQSTVEYVAKQLGIAHAFGNMSPCDK       550       560       570       580       590       600  600       610       620       630       640       650 m589.pepAAEVQKLKAAGKTVAMVGDGINDAPALAAANVSFAMKGGADVAEHTASATLMQHSVNQLA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g589AAEVQKLKAAGKTVAMVGDGINDAPALAAANVSFAMKGGADVAEHTASATLMQHSVNQLA610       620       630       640       650       660  660       670       680       690       700       710 m589.pepDALLVSQATLKNIKQNLFFAFFYNILGIPLAALGFLNPVIAGAAMAASSVSVLSNALRLK||||:|||||:||||||||||||||||||||||||||||||||||||||||||:|||||| g589DALLISQATLENIKQNLFFAFFYNILGIPLAALGFLNPVIAGAAMAASSVSVLGNALRLK       670       680       690       700       710       720   720m589.pep RVKIDX  ||||| g589 WVKIDXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1831>:

a589.seq 1 ATGCAACAAA AAGTCCGTTT CCAAATCGAA GGCATGACCT GCCAGGCATG 51TGCTTCGCGC ATTGAAAAAG TGTTGAACAA AAAAGATTTT GTCGAATCGG 101 CGGGGGTAAACTTCGCCAGC GAAGAGGCTC AGGTAGTGTT TGACGACAGC 151 AAAACCTCAG TAGCCGACATTGCCAAAATC ATTGAGAAAA CCGGTTACGG 201 CGCGAAGGAA AAAACGGAAG ATACATTGCCGCAACCCGAA GCAGAACACC 251 ATATCGGCTG GAGGTTGTGG CTTTTGCTGG CCATCAATATCCCGTTCCTT 301 ATCGGTATGG TAGGGATGAT GCTAAAAGGG CTGAATTGGA CACGGCATGA351 TTGGATGTTG TCGCCCTTGT TGCAGTTTGC ATTGGCGAGT GTGGTGCAGC 401TTTGGCTGGC GGTGCCATTT TACAAAAGCG CGTGGGCGAG CATTAAAGGC 451 GGGCTGGCGAATATGGACGT ACTCGTTACC ATCGGCACGG TCTCGATTTA 501 CCTGTATTCC GTCTATATGCTGTTTTTCAG CCCGCACGCG GCGTACGGTA 551 TGGCGCATGT GTATTTTGAA GTAGGCATAATGGTGATTGG TTTTGTGTCA 601 CTGGGTAAAT TTTTGGAACA CCGCACCAAA AAATCCAGCCTGAACAGCTT 651 GGGCTTGCTG CTCAAACTCA CGCCAACCCA AGTCAACGTG CAACGCGATG701 GCGAATGGCG GCAGCTACCC ATCGACCAAG TGCAAATCGG CGACCTAATC 751CGCGCCAATC ACGGCGAACG CATTGCCGCC GACGGCATCA TAGAAAGCGG 801 CAGCGGCTGGGCGGACGAAA GCCATCTTAC CGGCGAATCC AATCCCGAAG 851 AGAAAAAGGC AGGCGGCAAAGTATTGGCGG GCGCGCTGAT GACTGAAGGC 901 AGCGTGGTGT ACCGCGCCGC GCAGCTCGGCAGCCAAACCC TGCTCGGCGA 951 CATGATGAAC GCGCTCTCCG AAGCGCAAGG CAGTAAAGCACCGATTGCGC 1001 GTGTGGCGGA CAAGGCGGCG GCGGTATTCG TGCCTGCCGT TGTGGGCATC1051 GCACTTTTGA CTTTTATCGC TACTTGGCTG ATTAAGGGCG ATTGGACGCT 1101CGCATTGATG CACGCCGTCG CCGTTTTGGT GATTGCCTGC CCGTGTGCAC 1151 TCGGTTTGGCAACCCCTGCT GCGATTATGG TCGGTATGGG CAAAGCGGTT 1201 AAACACGGTA TTTGGTTTAAAGACGCGGCA GCAATGGAAG AAGCCGCCCA 1251 CGTTGATGCC GTCGTGCTGG ACAAAACCGGCACGCTGACC GAAGGCAAGC 1301 CGCAGGTTGC CGCCGTTTAT TGTGTTCCCG ACAGCGGCTTTGACGAAGAC 1351 GCTTTGTACC GCATCGCCGC CGCCGTCGAA CAAAACGCCG CCCATCCGCT1401 CGCCCGTGCC ATCGTCTCCG CCGCCCAGGC GCGCGGTTTG GAGATTCCCA 1451CCGCACAAAA TGCCCAAACC ATTGTCGGCG CGGGCATTAC CGCCGAAGTA 1501 AAAGGCGCGGGTTTGGTAAA AGCAGGCAAA GCCGAATTTG CCGAACTGAC 1551 CTTGCCGAAG TTTTCAGACGGCGTTTGGGA AATCGCCAGT GTGGTTGCCG 1601 TATCTGTAAA CGGCAAACCT ATCGGCGCATTCGCACTCGC CGACGCGTTG 1651 AAAGCCGATA CCGCCGAAGC CATAGGCCGT CTGAAAAAACACAATATCGA 1701 TGTCTATATT ATGAGCGGCG ATAACCAAGG CACGGTCGAG TACGTCGCCA1751 AACAACTGGG CATCGCACAC GCCTTCGGTA ATATGAGTCC GCGCGACAAA 1801GCCGCCGAAG TGCAGAAACT CAAAGCCGCC GGCAAAACCG TGGCGATGGT 1851 CGGCGACGGCATCAACGACG CGCCCGCGCT CGCCGCCGCC AACGTCAGCT 1901 TCGCCATGAA AGGCGGTGCAGACGTTGCCG AACACACCGC ATCCGCCACA 1951 CTGATGCAGC ATTCGGTCAA CCAGCTCGCCGATGCGCTAT CGGTATCGCG 2001 AGCGACGTTG AAAAACATCA AGCAAAACCT GTTTTTCGCCTTCTTCTACA 2051 ATATTTTGGG CATTCCGCTC GCCGCGCTCG GCTTTTTAAA CCCCGTCATC2101 GCAGGCGCGG CAATGGCGGC AAGCTCGGTT TCCGTGTTGA GCAACGCCTT 2151GCGCCTGAAA CGGGTAAAAA TCGATTGAThis corresponds to the amino acid sequence <SEQ ID 1832; ORF 589.a>:

a589.pep 1 MQQKVRFQIE GMTCQACASR IEKVLNKKDF VESAGVNFAS EEAQVVFDDS 51KTSVADIAKI IEKTGYGAKE KTEDTLPQPE AEHHIGWRLW LLLAINIPFL 101 IGMVGMMLKGLNWTRHDWML SPLLQFALAS VVQLWLAVPF YKSAWASIKG 151GLANMDVLVT IGTVSIYLYS VYMLFFSPHA AYGMAHVYFE VGIMVIGFVS 201 LGKFLEHRTKKSSLNSLGLL LKLTPTQVNV QRDGEWRQLP IDQVQIGDLI 251 RANHGERIAA DGIIESGSGWADESHLTGES NPEEKKAGGK VLAGALMTEG 301 SVVYRAAQLG SQTLLGDMMN ALSEAQGSKAPIARVADKAA AVFVPAVVGI 351 ALLTFIATWL IKGDWTLALM HAVAVLVIAC PCALGLATPAAIMVGMGKAV 401 KHGIWFKDAA AMEEAAHVDA VVLDKTGTLT EGKPQVAAVY CVPDSGFDED451 ALYRIAAAVE QNAAHPLARA IVSAAQARGL EIPTAQNAQT IVGAGITAEV 501KGAGLVKAGK AEFAELTLPK FSDGVWEIAS VVAVSVNGKP IGAFALADAL 551 KADTAEAIGRLKKHNIDVYI MSGDNQGTVE YVAKQLGIAH AFGNMSPRDK 601 AAEVQKLKAA GKTVAMVGDGINDAPALAAA NVSFAMKGGA DVAEHTASAT 651 LMQHSVNQLA DALSVSRATLKNIKQNLFFA FFYNILGIPL AALGFLNPVI 701 AGAAMAASSV SVLSNALRLK RVKID*m589/a589 94.9% identity in 725 aa overlap        10        20        30        40        50        60 m589.pepMQQKIRFQIEGMTCQACASRIEKVLNKKDFVESAGVNFASEEAQVVFDDSKTSVADIAKI||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||| a589MQQKVRFQIEGMTCQACASRIEKVLNKKDFVESAGVNFASEEAQVVFDDSKTSVADIAKI        10        20        30        40        50        60        70        80        90       100      1     110 m589.pepIEKTGYGAKEKTEDTLPQPEAEHHIGWRLWLLFTINVPFLIGMAGMMIG-----RHDWMI||||||||||||||||||||||||||||||||::||:||||||:|||:      |||||||||: a589IEKTGYGAKEKTEDTLPQPEAEHHIGWRLWLLLAINIPFLIGMVGMMLKGLNWTRHDWML        70        80        90       100       110       120  120       130       140       150       160       170 m589.pepPPLWQFALASVVQLWLAIPFYKSAWASIKGGLANMDVLVTIGTVSIYLYSVYMLFFSPHA || |||||||||||||:|||||||||||||||||||||||||||||||||||||||||| a589SPLLQFALASVVQLWLAVPFYKSAWASIKGGLANMDVLVTIGTVSIYLYSVYMLFFSPHA       130       140       150       160       170       180  180       190       200       210       220       230 m589.pepAYGMAHVYFEVGVMVIGFVSLGKFLEHRTKKSSLNSLGLLLKLTPTQVNVQRNGEWKQLP||||||||||||:|||||||||||||||||||||||||||||||||||||||:|||:||| a589AYGMAHVYFEVGIMVIGFVSLGKFLEHRTKKSSLNSLGLLLKLTPTQVNVQRDGEWRQLP       190       200       210       220       230       240  240       250       260       270       280       290 m589.pepIDQVQIGDLIRANHGERIAADGIIESGSGWADESHLTGESNPEEKKAGGKVLAGALMTEG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a589IDQVQIGDLIRANHGERIAADGIIESGSGWADESHLTGESNPEEKKAGGKVLAGALMTEG       250       260       270       280       290       300  300       310       320       330       340       350 m589.pepSVVYRATQLGSQTQLGDMMNALSEAQGSKAPIARVADKAAAVFVPAVVGIALLTFIVTWL||||||:|||||| ||||||||||||||||||||||||||||||||||||||||||:||| a589SVVYRAAQLGSQILLGDMMNALSEAQGSKAPIARVADKAAAVFVPAVVGIALLIFIATWL       310       320       330       340       350       360  360       370       380       390       400       410 m589.pepIKGDWTVALMHAVAVLVIACPCALGLATPAAIMVGMGKAVKHGIWFKDAAAMEEAAHVDA||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||| a589IKGDWTLALMHAVAVLVIACPCALGLATPAAIMVGMGKAVKHGIWFKDAAAMEEAAHVDA       370       380       390       400       410       420  420       430       440       450       460       470 m589.pepVVLDKTGTLTEGSPQVAAVYCVPDSGFDEDALYRIAAAVEQNAAHPLARAIVSAAQARGL||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| a589VVLDKTGTLTEGKPQVAAVYCVPDSGFDEDALYRIAAAVEQNAAHPLARAIVSAAQARGL       430       440       450       460       470       480  480       490       500       510       520       530 m589.pepDIPAAQNAQTVVGAGITAEVEGVGLVKAGKAEFAELALPKFLDGVWDIASIVAVSVDNKP:||:||||||:|||||||||:|:|||||||||||||:|||| ||||:|||:|||||::|| a589EIPTAQNAQTIVGAGITAEVKGAGLVKAGKAEFAELTLPKFSDGVWEIASVVAVSVNGKP       490       500       510       520       530       540  540       550       560       570       580       590 m589.pepIGAFALADALKADTAEAIGRLKKHNIDVYIMSGDNQGTVEYVAKQLGIAHAFGNMSPRDK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a589IGAFALADALKADTAEAIGRLKKHNIDVYIMSGDNQGTVEYVAKQLGIAHAFGNMSPRDK       550       560       570       580       590       600  600       610       620       630       640       650 m589.pepAAEVQKLKAAGKTVAMVGDGINDAPALAAANVSFAMKGGADVAEHTASATLMQHSVNQLA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a589AAEVQKLKAAGKTVAMVGDGINDAPALAAANVSFAMKGGADVAEHTASATLMQHSVNQLA       610       620       630       640       650       660  660       670       680       690       700       710 m589.pepDALLVSQATLKNIKQNLFFAFFYNILGIPLAALGFLNPVIAGAAMAASSVSVLSNALRLK||| ||:||||||||||||||||||||||||||||||||||||||||||||||||||||| a589DALSVSRATLKNIKQNLFFAFFYNILGIPLAALGFLNPVIAGAAMAASSVSVLSNALRLK       670       680       690       700       710       720   720m589.pep RVKIDX |||||| a589 RVKIDXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1833>:

g590.seq.. 1 atgaaaaaac ctttgatttc agttgcggca gtattgctcg gcgttgcttt 51gggtacacct tattatttgg gtgtcaaagc agaagaaagt ctgacgcagc 101 agcaaaaaatattgcagaaa acgggctttt tgaccgtcga atcgcaccag 151 tatgatcgag gctggtttacctctacggaa acgacggtca tccgtctgaa 201 acccgagttg ctgcataatg cgcagaaatacctgccggat aacttgaaaa 251 tagtgttgga acagccggtt acgctggtaa accatatcacgcacggccct 301 ttcgccggcg gattcggcac gcaggcgcac attgaaaccg agttcaaata351 cgcgcctgaa acggaaaaag ttttggaacg cttttttggg aaacaagttc 401cggtttccct tgccaatacc gtttatttca acggcagcgg taaaatggaa 451 gtcagtgttcccgctttcga ttatgaagaa ctgtcgggca tcaggctgca 501 ctgggaaggc ctgacgggggaaacggttta tcaaaaaggt ttcaaaagct 551 accgcaacag ctatgatgcg cccttgttcaaaatcaagct ggcagacaaa 601 ggcgatgccg cgtttgaaaa agcgcatttc gattcggaaacttcagacgg 651 catcaatccg cttgctttgg gcagcagcaa tctgactttg gaaaaatttt701 cgctcgaatg gaaagagggt gtcgattaca acgtcaaatt gaacgaactg 751gtcaacctcg ttaccgattt gcagatcggc gcgtttatca atcccaacgg 801 cagcatcgcaccttccaaaa tcgaagtcgg caagctggct ttttcaacca 851 agaccgggga atcgggcgcgtttatcgaca gcgaagggcg gttccgtttc 901 gatacgttgg tgtacggcga tgaaaaatacggcccgctgg acatccatat 951 cgctgccgaa cacctcgatg cttctgcctt aaccgtattgaaacgcaagt 1001 ttgcacaaat ttctgccaaa aaaatgactg aggaacaaat ccgcaatgat1051 ttgattgcgg cagtcaaagg cgatgcttcc ggattattta cccatgaccc 1101ggtactaaat atcaaaattt tccgtttcac cctgcctcag ggaaaaattg 1151 atgtgggcggaaaaatcatg tttaaaggca tgaagaagga agatttgaac 1201 caattgggac tgatgttaaagaaaaccgag gcaaacatca gaatgagtat 1251 tcctcaaaaa atgttggaag atttggcggtaagtcaggct ggaaatattt 1301 tcagtgtaaa tgccgaagat gaggcggaag ccagagcaagcattgccgat 1351 attaatgaaa cattgcgcct gatggtggac agtacggtcc aaagtatggc1401 aagggaaaaa tatcttactt tagacggtaa tcagattgat acggtcattt 1451cccttaaaaa caacgccctg aagttaaacg ggaaaacgct gcaaaatgaa 1501 cccgatcctgattttgacga gggagatatg gtttccggcc agccgcatta 1551 aThis corresponds to the amino acid sequence <SEQ ID 1834; ORF 590.ng>:

g590.pep.. 1 MKKPLISVAA VLLGVALGTP YYLGVKAEES LTQQQKILQK TGFLTVESHQ 51YDRGWFTSTE TTVIRLKPEL LHNAQKYLPD NLKIVLEQPV TLVNHITHGP 101 FAGGFGTQAHIETEFKYAPE TEKVLERFFG KQVPVSLANT VYFNGSGKME 151 VSVPAFDYEE LSGIRLHWEGLTGETVYQKG FKSYRNSYDA PLFKIKLADK 201 GDAAFEKAHF DSETSDGINP LALGSSNLTLEKFSLEWKEG VDYNVKLNEL 251 VNLVTDLQIG AFINPNGSIA PSKIEVGKLA FSTKTGESGAFIDSEGRFRF 301 DTLVYGDEKY GPLDIHIAAE HLDASALTVL KRKFAQISAK KMTEEQIRND351 LIAAVKGDAS GLFTHDPVLN IKIFRFTLPQ GKIDVGGKIM FKGMKKEDLN 401QLGLMLKKTE ANIRMSIPQK MLEDLAVSQA GNIFSVNAED EAEARASIAD 451 INETLRLMVDSTVQSMAREK YLTLDGNQID TVISLKNNAL KLNGKTLQNE 501 PDPDFDEGDM VSGQPH*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1835>:

m590.seq (partial) .. 1 ..TGGTTTACCT CTATGGAAAC GACGGTCATC CGTCTGAAACCCGAGTTGCT 51   GAATAATGCC CGAAAATACC TGCCGGATAA CCTGAAAACA GTGTTGGAAC101   AGCCGGTTAC GCTGGTTAAC CATATCACGC ACGGCCCTTT CGCCGGCGGA 151  TTCGGCACGC AGGCGTACAT TGAAACCGAG TTCAAATACG CGCCTGAAAC 201  GGAAAAAGTT CTGGAACGCT TTTTTGGAAA ACAAGTCCCG GCTTCCCTTG 251  CCAATACCGT TTATTTTAAC GGCAGCGGTA AAATGGAAGT CAGTGTTCCC 301  GCCTTCGATT ATGAAGAGCT GTCGGGCATc AG.CTGCACT GGGAAkGCCT 351  GACGGGAGAA ACGGTTTATC AAAAAGGTTT CAAAAGCTAC CGGAACGGCT 401  ATGATGCCCC CTTGTTTAAA ATCAAGCTGG CAGACAAAGG CGATGCCGCG 451  TTTGAAAAAG TGCATTTCGA TTCGGAAACT TCAGACGGCA TCAATCCGCT 501  TGCTTTGGGC AGCAGCAATC TGACCTTGGA AAAATTCTCC CTAGAATGGA 551  AAGAGGGTGT CGATTACAAC GTCAAGTTAA ACGAACTGGT CAATCTTGTT 601  ACCGATTTGC AGATTGGCGC GTTTATCAAT CCCAACGGCA GCATCGCACC 651  TTCCAAAATC GAAGTCGGCA AACTGGCTTT TTCAACCAAG ACCGGGGAAT 701  CAGGCGCGTT TATCAACAGT GAAGGGCAGT TCCGTTTCGA TACACTGGTG 751  TACGGCGATG AAAAATACGG CCCGCTGGAC ATCCATATCG CTGCCGAACA 801  CCTCGATGCT TCTGCCTTAA CCGTATTGAA ACGCAAGTTT GCACAAATTT 851  CCGCCAAAAA AATGACCGAG GAACAAATCC GCAATGATTT GATTGCCGCC 901  GTCAAAGGAG AGGCTTCCGG ACTGTTCACC AACAATCCCG TATTGGACAT 951  TAAAACTTTC CGATTCACGC TGCCATCGGG AAAAATCGAT GTGGGCGGAA 1001  AAATCATGTT TAAAGACATG AAGAAGGAAG ATTTGAATCA ATTGGGTTTG 1051  ATGCTGAAGA AAACCGAAGC CGACATCAGA ATGAGTATTC CCCAAAAAAT 1101  GCTGGAAGAC TTGGCGGTCA GTCAAGCAGG CAATATTTTC AGCGTCAATG 1151  CCGAAGATGA GGCGGAAGGC AGGGCAAGTC TTGACGACAT CAACGAGACC 1201  TTGCGCCTGA TGGTGGACAG TACGGTTCAG AGTATGGCAA GGGAAAAATA 1251  TCTGACTTTG AACGGCGACC AGATTGATAC TGCCATTTCT CTGAAAAACA 1301  ATCAGTTGAA ATTGAACGGT AAAACGTTGC AAAACGAACC GGAGCCGGAT 1351  TTTGATGAAG GCGGTATGGT TTCAGAGCCG CAGCAGTAAThis corresponds to the amino acid sequence <SEQ ID 1836; ORF 590>:

m590.pep..(partial) 1 ..WFTSMETTVI RLKPELLNNA RKYLPDNLKT VLEQPVTLVNHITHGPFAGG 51   FGTQAYIETE FKYAPETEKV LERFFGKQVP ASLANTVYFN GSGKMEVSVP101   AFDYEELSGI XLHWEXLTGE TVYQKGFKSY RNGYDAPLFK IKLADKGDAA 151  FEKVHFDSET SDGINPLALG SSNLTLEKFS LEWKEGVDYN VKLNELVNLV 201  TDLQIGAFIN PNGSIAPSKI EVGKLAFSTK TGESGAFINS EGQFRFDTLV 251  YGDEKYGPLD IHIAAEHLDA SALTVLKRKF AQISAKKMTE EQIRNDLIAA 301  VKGEASGLFT NNPVLDIKTF RFTLPSGKID VGGKIMFKDM KKEDLNQLGL 351  MLKKTEADIR MSIPQKMLED LAVSQAGNIF SVNAEDEAEG RASLDDINET 401  LRLMVDSTVQ SMAREKYLTL NGDQIDTAIS LKNNQLKLNG KTLQNEPEPD 451  FDEGGMVSEP QQ* m590/g590 93.1% identity in 462 aa overlap                                      10        20        30 m590.pep                              WFTSMETTVIRLKPELLNNARKYLPDNLKT                              |||| ||||||||||||:||:|||||||| g590VKAEESLTQQQKILQKTGFLTVESHQYDRGWFTSTETTVIRLKPELLHNAQKYLPDNLKI    30        40        50        60        70        80        40        50        60        70        80        90 m590.pepVLEQPVTLVNHITHGPFAGGFGTQAYIETEFKYAPETEKVLERFFGKQVPASLANTVYFN|||||||||||||||||||||||||:||||||||||||||||||||||||:||||||||| g590VLEQPVTLVNHITHGPFAGGFGTQAHIETEFKYAPETEKVLERFFGKQVPVSLANTVYFN    90       100       110       120       130       140       100       110       120       130       140       150 m590.pepGSGKMEVSVPAFDYEELSGIXLHWEXLTGETVYQKGFKSYRNGYDAPLFKIKLADKGDAA|||||||||||||||||||| |||| ||||||||||||||||:||||||||||||||||| g590GSGKMEVSVPAFDYEELSGIRLHWEGLTGETVYQKGFKSYRNSYDAPLFKIKLADKGDAA   150       160       170       180       190       200       160       170       180       190       200       210 m590.pepFEKVHFDSETSDGINPLALGSSNLTLEKFSLEWKEGVDYNVKLNELVNLVTDLQIGAFIN|||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||| g590FEKAHFDSETSDGINPLALGSSNLTLEKFSLEWKEGVDYNVKLNELVNLVTDLQIGAFIN   210       220       230       240       250       260       220       230       240       250       260       270 m590.pepPNGSIAPSKIEVGKLAFSTKTGESGAFINSEGQFRFDTLVYGDEKYGPLDIHIAAEHLDA||||||||||||||||||||||||||||:|||:||||||||||||||||||||||||||| g590PNGSIAPSKIEVGKLAFSTKTGESGAFIDSEGRFRFDTLVYGDEKYGPLDIHIAAEHLDA   270       280       290       300       310       320       280       290       300       310       320       330 m590.pepSALTVLKRKFAQISAKKMTEEQIRNDLIAAVKGEASGLFTNNPVLDIKTFRFTLPSGKID|||||||||||||||||||||||||||||||||:||||||::|||:|| ||||||:|||| g590SALTVLKRKFAQISAKKMTEEQIRNDLIAAVKGDASGLFTHDPVLNIKIFRFTLPQGKID   330       340       350       360       370       380       340       350       360       370       380       390 m590.pepVGGKIMFKDMKKEDLNQLGLMLKKTEADIRMSIPQKMLEDLAVSQAGNIFSVNAEDEAEG|||||||| ||||||||||||||||||:|||||||||||||||||||||||||||||||: g590VGGKIMFKGMKKEDLNQLGLMLKKTEANIRMSIPQKMLEDLAVSQAGNIFSVNAEDEAEA   390       400       410       420       430       440       400       410       420       430       440       450 m590.pepRASLDDINETLRLMVDSTVQSMAREKYLTLNGDQIDTAISLKNNQLKLNGKTLQNEPEPD |||:|||||||||||||||||||||||||:|:||||:|||||| ||||||||||||:|| g590RASIADINETLRLMVDSTVQSMAREKYLTLDGNQIDTVISLKNNALKLNGKTLQNEPDPD   450       460       470       480       490       500         460m590.pep FDEGGMVS-EPQQX |||| ||| :|: g590 FDEGDMVSGQPHX    510The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1837>:

a590.seq 1 ATGAAAAAAC CTTTGATTTC GGTTGCGGCA GCATTGCTCG GCGTTGCTTT 51GGGCACGCCT TATTATTTGG GTGTCAAAGC CGAAGAAAGC TTGACGCAGC 101 AGCAAAAAATATTGCAGGAA GCGGGCTTCT TGACCGTCGA ATCGCACCAA 151 TATGAGCGCG GCTGGTTTACCTCTACGGAA ACGACGGTCA TCCGCTTGAA 201 ACCCGAGTTG CTGCATAATG CGCAGAAATACCTGCCGGAT AACCTGAAAA 251 CAGTGTTGGA ACAGCCGGTT ACGCTGGTAA ACCATATCACGCACGGTCCT 301 TTTGCCGGCG GATTCGGCAC GCAGGCGTAC ATTGAAACCG AGTTCAAATA351 CGCGCCTGAA ACGGAAAAAG TTCTGGAACG CTTTTTTGGA AAACAAGTCC 401CGGTTTCCCT TGCCAATACC GTTTATTTTA ACGGCAGCGG TAAAATGGAA 451 GTCAGTGTTCCCGCCTTCGA TTATGAAGAG CTGTCGGGCA TCAGGCTGCA 501 CTGGGAAGGC CTGACGGGAGAAACGGTTTA TCAAAAAGGT TTCAAAAGCT 551 ACCGGAACGG CTATGATGCC CCCTTGTTTAAAATCAAGCT GGCAGACAAA 601 GGCGATGCCG CGTTTGAAAA AGTGCATTTC GATTCGGAAACTTCAGACGG 651 CATCAACCCG CTTGCTTTGG GCAGCAGCAA TCTGACCTTG GAAAAATTTT701 CCTTAGAATG GAAAGAGGGT GTCGATTACA ACGTCAAGTT AAACGAACTG 751GTCAATCTTG TTACCGATTT GCAGATTGGC GCGTTTATCA ATCCCAACGG 801 CAGCATCGCACCTTCCAAAA TCGAAGTCGG CAAGCTGGCT TTTTCAACCA 851 AGACCGGGGA ATCGGGCGCGTTTATCGATA GCGAAGGGCA GTTCCGTTTT 901 GGCACGCTGG TTTACGGCGA TGAAAAATACGGCCCTCTGG ACATCCATAT 951 CGCTGCCGAA CACCTCGATG CTTCTGCCTT AACCGTATTGAAACGCAAGT 1001 TTGCACGAAT TTCTGCCAAA AAAATGACTG AAGAACAAAT CCGCAATGAT1051 TTGATTGCGG CAGTCAAAGG CGAGGCTTCC GGATTATTTA CCCATAACCC 1101AGTATTGGAC ATTAAAACTT TCCGATTCAC GCTGCCATCG GGAAAAATCG 1151 ATGTGGGCGGAAAAATCATG TTTAAAGACA TGAAGAAGGA AGATTTGAAC 1201 CAATTGGGTT TGATGCTGAAGAAAACCGAA GCCGACATCA GAATGAGTAT 1251 TCCCCAAAAA ATGCTGGAAG ACTTGGCGGTCAGTCAAGCA GGCAATATTT 1301 TCAGCGTCAA TGCCGAAGAT GAGGCGGAAG GCAGGGCAAGTCTTGACGAC 1351 ATCAACGAGA CCTTGCGCCT GATGGTGGAC AGTACGGTTC AGAGTATGGC1401 AAGGGAAAAA TATCTGACTT TGAACGGCGA CCAGATTGAT ACTGCCATTT 1451CTCTGAAAAA CAATCAGTTG AAATTGAACG GTAAAACGTT GCAAAACGAA 1501 CCGGAGCCGGATTTTGATGA AGGCGGTATG GTTTCAGAGC CGCAGCAGTA 1551 AThis corresponds to the amino acid sequence <SEQ ID 1838; ORF 590.a>:

a590.pep 1 MKKPLISVAA ALLGVALGTP YYLGVKAEES LTQQQKILQE AGFLTVESHQ 51YERGWFTSTE TTVIRLKPEL LHNAQKYLPD NLKTVLEQPV TLVNHITHGP 101 FAGGFGTQAYIETEFKYAPE TEKVLERFFG KQVPVSLANT VYFNGSGKME 151 VSVPAFDYEE LSGIRLHWEGLTGETVYQKG FKSYRNGYDA PLFKIKLADK 201 GDAAFEKVHF DSETSDGINP LALGSSNLTLEKFSLEWKEG VDYNVKLNEL 251 VNLVTDLQIG AFINPNGSIA PSKIEVGKLA FSTKTGESGAFIDSEGQFRF 301 GTLVYGDEKY GPLDIHIAAE HLDASALTVL KRKFARISAK KMTEEQIRND351 LIAAVKGEAS GLFTHNPVLD IKTFRFTLPS GKIDVGGKIM FKDMKKEDLN 401QLGLMLKKTE ADIRMSIPQK MLEDLAVSQA GNIFSVNAED EAEGRASLDD 451 INETLRLMVDSTVQSMAREK YLTLNGDQID TAISLKNNQL KLNGKTLQNE 501 PEPDFDEGGM VSEPQQ*m590/a590 97.8% identity in 462 aa overlap                                      10        20        30 m590.pep                              WFTSMETTVIRLKPELLNNARKYLPDNLKT                              |||| ||||||||||||:||:||||||||| a590VKAEESLTQQQKILQEAGFLTVESHQYERGWFTSTETTVIRLKPELLHNAQKYLPDNLKT    30        40        50        60        70        80        40        50        60        70        80        90 m590.pepVLEQPVTLVNHITHGPFAGGFGTQAYIETEFKYAPETEKVLERFFGKQVPASLANTVYFN||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| a590VLEQPVTLVNHITHGPFAGGFGTQAYIETEFKYAPETEKVLERFFGKQVPVSLANTVYFN    90       100       110       120       130       140       100       110       120       130       140       150 m590.pepGSGKMEVSVPAFDYEELSGIXLHWEXLTGETVYQKGFKSYRNGYDAPLFKIKLADKGDAA|||||||||||||||||||| |||| |||||||||||||||||||||||||||||||||| a590GSGKMEVSVPAFDYEELSGIRLHWEGLTGETVYQKGFKSYRNGYDAPLFKIKLADKGDAA   150       160       170       180       190       200       160       170       180       190       200       210 m590.pepFEKVHFDSETSDGINPLALGSSNLTLEKFSLEWKEGVDYNVKLNELVNLVTDLQIGAFIN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a590FEKVHFDSETSDGINPLALGSSNLTLEKFSLEWKEGVDYNVKLNELVNLVTDLQIGAFIN   210       220       230       240       250       260       220       230       240       250       260       270 m590.pepPNGSIAPSKIEVGKLAFSTKTGESGAFINSEGQFRFDTLVYGDEKYGPLDIHIAAEHLDA||||||||||||||||||||||||||||:||||||| ||||||||||||||||||||||| a590PNGSIAPSKIEVGKLAFSTKTGESGAFIDSEGQFRFGTLVYGDEKYGPLDIHIAAEHLDA   270       280       290       300       310       320       280       290       300       310       320       330 m590.pepSALTVLKRKFAQISAKKMTEEQIRNDLIAAVKGEASGLFTNNPVLDIKTFRFTLPSGKID|||||||||||:||||||||||||||||||||||||||||:||||||||||||||||||| a590SALTVLKRKFARISAKKMTEEQIRNDLIAAVKGEASGLFTHNPVLDIKTFRFTLPSGKID   330       340       350       360       370       380       340       350       360       370       380       390 m590.pepVGGKIMFKDMKKEDLNQLGLMLKKTEADIRMSIPQKMLEDLAVSQAGNIFSVNAEDEAEG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a590VGGKIMFKDMKKEDLNQLGLMLKKTEADIRMSIPQKMLEDLAVSQAGNIFSVNAEDEAEG   390       400       410       420       430       440       400       410       420       430       440       450 m590.pepRASLDDINETLRLMVDSTVQSMAREKYLTLNGDQIDTAISLKNNQLKLNGKTLQNEPEPD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a590RASLDDINETLRLMVDSTVQSMAREKYLTLNGDQIDTAISLKNNQLKLNGKTLQNEPEPD   450       460       470       480       490       500        460m590.pep FDEGGMVSEPQQX ||||||||||||| a590 FDEGGMVSEPQQX    510The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1839>:

m590-1.seq 1 ATGAAAAAAC CTTTGATTTC GGTTGCGGCA GCATTGCTCG GCGTTGCTTT 51GGGCACGCCT TATTATTTGG GTGTCAAAGC CGAAGAAAGC TTGACGCAGC 101 AGCAAAAAATATTGCAGGAA ACGGGCTTCT TGACCGTCGA ATCGCACCAA 151 TATGAGCGCG GCTGGTTTACCTCTATGGAA ACGACGGTCA TCCGTCTGAA 201 ACCCGAGTTG CTGAATAATG CCCGAAAATACCTGCCGGAT AACCTGAAAA 251 CAGTGTTGGA ACAGCCGGTT ACGCTGGTTA ACCATATCACGCACGGCCCT 301 TTCGCCGGCG GATTCGGCAC GCAGGCGTAC ATTGAAACCG AGTTCAAATA351 CGCGCCTGAA ACGGAAAAAG TTCTGGAACG CTTTTTTGGA AAACAAGTCC 401CGGCTTCCCT TGCCAATACC GTTTATTTTA ACGGCAGCGG TAAAATGGAA 451 GTCAGTGTTCCCGCCTTCGA TTATGAAGAG CTGTCGGGCA TCAGGCTGCA 501 CTGGGAAGGC CTGACGGGAGAAACGGTTTA TCAAAAAGGT TTCAAAAGCT 551 ACCGGAACGG CTATGATGCC CCCTTGTTTAAAATCAAGCT GGCAGACAAA 601 GGCGATGCCG CGTTTGAAAA AGTGCATTTC GATTCGGAAACTTCAGACGG 651 CATCAATCCG CTTGCTTTGG GCAGCAGCAA TCTGACCTTG GAAAAATTCT701 CCCTAGAATG GAAAGAGGGT GTCGATTACA ACGTCAAGTT AAACGAACTG 751GTCAATCTTG TTACCGATTT GCAGATTGGC GCGTTTATCA ATCCCAACGG 801 CAGCATCGCACCTTCCAAAA TCGAAGTCGG CAAACTGGCT TTTTCAACCA 851 AGACCGGGGA ATCAGGCGCGTTTATCAACA GTGAAGGGCA GTTCCGTTTC 901 GATACACTGG TGTACGGCGA TGAAAAATACGGCCCGCTGG ACATCCATAT 951 CGCTGCCGAA CACCTCGATG CTTCTGCCTT AACCGTATTGAAACGCAAGT 1001 TTGCACAAAT TTCCGCCAAA AAAATGACCG AGGAACAAAT CCGCAATGAT1051 TTGATTGCCG CCGTCAAAGG AGAGGCTTCC GGACTGTTCA CCAACAATCC 1101CGTATTGGAC ATTAAAACTT TCCGATTCAC GCTGCCATCG GGAAAAATCG 1151 ATGTGGGCGGAAAAATCATG TTTAAAGACA TGAAGAAGGA AGATTTGAAT 1201 CAATTGGGTT TGATGCTGAAGAAAACCGAA GCCGACATCA GAATGAGTAT 1251 TCCCCAAAAA ATGCTGGAAG ACTTGGCGGTCAGTCAAGCA GGCAATATTT 1301 TCAGCGTCAA TGCCGAAGAT GAGGCGGAAG GCAGGGCAAGTCTTGACGAC 1351 ATCAACGAGA CCTTGCGCCT GATGGTGGAC AGTACGGTTC AGAGTATGGC1401 AAGGGAAAAA TATCTGACTT TGAACGGCGA CCAGATTGAT ACTGCCATTT 1451CTCTGAAAAA CAATCAGTTG AAATTGAACG GTAAAACGTT GCAAAACGAA 1501 CCGGAGCCGGATTTTGATGA AGGCGGTATG GTTTCAGAGC CGCAGCAGTA 1551 AThis corresponds to the amino acid sequence <SEQ ID 1840; ORF 590-1>:

m590-1.pep 1 MKKPLISVAA ALLGVALGTP YYLGVKAEES LTQQQKILQE TGFLTVESHQ 51YERGWFTSME TTVIRLKPEL LNNARKYLPD NLKTVLEQPV TLVNHITHGP 101 FAGGFGTQAYIETEFKYAPE TEKVLERFFG KQVPASLANT VYFNGSGKME 151 VSVPAFDYEE LSGIRLHWEGLTGETVYQKG FKSYRNGYDA PLFKIKLADK 201 GDAAFEKVHF DSETSDGINP LALGSSNLTLEKFSLEWKEG VDYNVKLNEL 251 VNLVTDLQIG AFINPNGSIA PSKIEVGKLA FSTKTGESGAFINSEGQFRF 301 DTLVYGDEKY GPLDIHIAAE HLDASALTVL KRKFAQISAK KMTEEQIRND351 LIAAVKGEAS GLFTNNPVLD IKTFRFTLPS GKIDVGGKIM FKDMKKEDLN 401QLGLMLKKTE ADIRMSIPQK MLEDLAVSQA GNIFSVNAED EAEGRASLDD 451 INETLRLMVDSTVQSMAREK YLTLNGDQID TAISLKNNQL KLNGKTLQNE 501 PEPDFDEGGM VSEPQQ*m590-1/g590 93.6% identity in 516 aa overlap        10        20        30        40        50        60 m590-1.pepMKKPLISVAAALLGVALGTPYYLGVKAEESLTQQQKILQETGFLTVESHQYERGWFTSME||||||||||:||||||||||||||||||||||||||||:|||||||||||:|||||| | g590MKKPLISVAAVLLGVALGTPYYLGVKAEESLTQQQKILQKTGFLTVESHQYDRGWFTSTE        10        20        30        40        50        60        70        80        90       100       110       120 m590-1.pepTTVIRLKPELLNNARKYLPDNLKTVLEQPVTLVNHITHGPFAGGFGTQAYIETEFKYAPE|||||||||||:||:|||||||| |||||||||||||||||||||||||:|||||||||| g590TTVIRLKPELLHNAQKYLPDNLKIVLEQPVTLVNHITHGPFAGGFGTQAHIETEFKYAPE        70        80        90       100       110       120       130       140       150       160       170       180 m590-1.pepTEKVLERFFGKQVPASLANTVYFNGSGKMEVSVPAFDYEELSGIRLHWEGLTGETVYQKG||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||| g590TEKVLERFFGKQVPVSLANTVYFNGSGKMEVSVPAFDYEELSGIRLHWEGLTGETVYQKG       130       140       150       160       170       180       190       200       210       220       230       240 m590-1.pepFKSYRNGYDAPLFKIKLADKGDAAFEKVHFDSETSDGINPLALGSSNLTLEKFSLEWKEG||||||:||||||||||||||||||||:|||||||||||||||||||||||||||||||| g590FKSYRNSYDAPLFKIKLADKGDAAFEKAHFDSETSDGINPLALGSSNLTLEKFSLEWKEG       190       200       210       220       230       240       250       260       270       280       290       300 m590-1.pepVDYNVKLNELVNLVTDLQIGAFINPNGSIAPSKIEVGKLAFSTKTGESGAFINSEGQFRF||||||||||||||||||||||||||||||||||||||||||||||||||||:|||:||| g590VDYNVKLNELVNLVTDLQIGAFINPNGSIAPSKIEVGKLAFSTKTGESGAFIDSEGRFRF       250       260       270       280       290       300       310       320       330       340       350       360 m590-1.pepDTLVYGDEKYGPLDIHIAAEHLDASALTVLKRKFAQISAKKMTEEQIRNDLIAAVKGEAS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| g590DTLVYGDEKYGPLDIHIAAEHLDASALTVLKRKFAQISAKKMTEEQIRNDLIAAVKGDAS       310       320       330       340       350       360       370       380       390       400       410       420 m590-1.pepGLFTNNPVLDIKTFRFTLPSGKIDVGGKIMFKDMKKEDLNQLGLMLKKTEADIRMSIPQK||||::|||:|| ||||||:|||||||||||| ||||||||||||||||||:|||||||| g590GLFTHDPVLNIKIFRFTLPQGKIDVGGKIMFKGMKKEDLNQLGLMLKKTEANIRMSIPQK       370       380       390       400       410       420       430       440       450       460       470       480 m590-1.pepMLEDLAVSQAGNIFSVNAEDEAEGRASLDDINETLRLMVDSTVQSMAREKYLTLNGDQID|||||||||||||||||||||||:|||: |||||||||||||||||||||||||:|:||| g590MLEDLAVSQAGNIFSVNAEDEAEARASIADINETLRLMVDSTVQSMAREKYLTLDGNQID       430       440       450       460       470       480       490       500       510 m590-1.pepTAISLKNNQLKLNGKTLQNEPEPDFDEGGMVS-EPQQX|:|||||| ||||||||||||:|||||| ||| :|: g590TVISLKNNALKLNGKTLQNEPDPDFDEGDMVSGQPHX        490       500       510a590/m590-1 98.3% identity in 516 aa overlap        10        20        30        40        50        60 a590.pepMKKPLISVAAALLGVALGTPYYLGVKAEESLTQQQKILQEAGFLTVESHQYERGWFTSTE||||||||||||||||||||||||||||||||||||||||:||||||||||||||||| | m590-1MKKPLISVAAALLGVALGTPYYLGVKAEESLTQQQKILQETGFLTVESHQYERGWFTSME        10        20        30        40        50        60        70        80        90       100       110       120 a590.pepTTVIRLKPELLHNAQKYLPDNLKTVLEQPVTLVNHITHGPFAGGFGTQAYIETEFKYAPE|||||||||||:||:||||||||||||||||||||||||||||||||||||||||||||| m590-1TTVIRLKPELLNNARKYLPDNLKTVLEQPVTLVNHITHGPFAGGFGTQAYIETEFKYAPE        70        80        90       100       110       120       130       140       150       160       170       180 a590.pepTEKVLERFFGKQVPVSLANTVYFNGSGKMEVSVPAFDYEELSGIRLHWEGLTGETVYQKG||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||| m590-1TEKVLERFFGKQVPASLANTVYFNGSGKMEVSVPAFDYEELSGIRLHWEGLTGETVYQKG       130       140       150       160       170       180       190       200       210       220       230       240 a590.pepFKSYRNGYDAPLFKIKLADKGDAAFEKVHFDSETSDGINPLALGSSNLTLEKFSLEWKEG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m590-1FKSYRNGYDAPLFKIKLADKGDAAFEKVHFDSETSDGINPLALGSSNLTLEKFSLEWKEG       190       200       210       220       230       240       250       260       270       280       290       300 a590.pepVDYNVKLNELVNLVTDLQIGAFINPNGSIAPSKIEVGKLAFSTKTGESGAFIDSEGQFRF||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||| m590-1VDYNVKLNELVNLVTDLQIGAFINPNGSIAPSKIEVGKLAFSTKTGESGAFINSEGQFRF       250       260       270       280       290       300       310       320       330       340       350       360 a590.pepGTLVYGDEKYGPLDIHIAAEHLDASALTVLKRKFARISAKKMTEEQIRNDLIAAVKGEAS||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| m590-1DTLVYGDEKYGPLDIHIAAEHLDASALTVLKRKFAQISAKKMTEEQIRNDLIAAVKGEAS       310       320       330       340       350       360       370       380       390       400       410       420 a590.pepGLFTHNPVLDIKTFRFTLPSGKIDVGGKIMFKDMKKEDLNQLGLMLKKTEADIRMSIPQK||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||| m590-1GLFTNNPVLDIKTFRFTLPSGKIDVGGKIMFKDMKKEDLNQLGLMLKKTEADIRMSIPQK       370       380       390       400       410       420       430       440       450       460       470       480 a590.pepMLEDLAVSQAGNIFSVNAEDEAEGRASLDDINETLRLMVDSTVQSMAREKYLTLNGDQID|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m590-1MLEDLAVSQAGNIFSVNAEDEAEGRASLDDINETLRLMVDSTVQSMAREKYLTLNGDQID       430       440       450       460       470       480       490       500       510 a590.pepTAISLKNNQLKLNGKTLQNEPEPDFDEGGMVSEPQQX||||||||||||||||||||||||||||||||||||| m590-1TAISLKNNQLKLNGKTLQNEPEPDFDEGGMVSEPQQX        490       500       510The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1841>:

g591.seq 1 TTGCAAACCC TTCTAGCTTT TATCTTCGCC ATCCTGATTT TGGTCAGCCT 51GCACGAATTC GGACACTACA TCGTCGCCAG GTTGTGCGGC GTCAAGGTTG 101 TGCGTTTTTCCGTCGGCTTC GGCAAACCGT TTTTCACCCG AAAGCGCGGC 151 GACACCGAAT GGTGCCTCGCCCCGATTCCG TTGGGCGGCT ACGTCAAAAT 201 GGTCGATACG CGCGAAGGCG AAGTATCAGAAGCCGATTTA CCCTACGCTT 251 TTGACAAACA ACACCCCGCC AAGCGCATCG CCATCGTCGCCGCCGGTCCG 301 CTGACCAACC TCGCActggc ggTTTTGCTG TACGGACTGa gctTttcctt351 cggcgtaaCC GAACTGCGGC CCtatgtcgg cacagtcgaA cccgacaccg 401ttgccgCCCG CACCGGCTTC caaagcggcg acaaAATACa atccgtcaac 451 ggcgtTtccgtCCAAGACTG GAGCAGCGCG CAAACCGAAA TCGTcctcAA 501 CCTCGAAGCC GgcaaagtcgccgtcggcgT TCAGACGGCA TCGGGCGCGC 551 AAACCGTCCG CACCAtcgAT GCCGCAGGCACGCCGGAAGC CGGTAAAATC 601 GCAAAAAACC AAGGCTACAT CGGACTGATG CCCTTTAAAATCACAACCGT 651 TGCCGGCGGC GTGGAAAAAG GCAGCCCCGC CGAAAAAGCA GGCCTGAAAC701 CGGGCGACAG GCTGACTGCC GCCGACGGCA AACCCATCGc ctcaTGGCAG 751GAATGggcaa acctgACccg cCAAAGCCCg ggcAAAAAAA Tcaccctgac 801 ctacgAaCGCGCcggacaaa cccaTAccgc CGACATCCGC CccgATactg 851 TCGAAcagcc cgACCACACCCTGATCgggc gcgTCGGCCT CCGtccgcaG 901 CCGGACAGGG CGTGGGACGC GCAAATCCGCCGCAGCTACC GTCCGTCTGT 951 TGTCCGCGCA TTCGGCATGG GCTGGGAAAA AACCGTTTCCCACTCGTGGA 1001 CAACCCTCAA ATTTTTCGGC AAACTAATCA GCGGCAACGC CTCTGTCAGC1051 CATATTTCCG GGCCGCTGAC CATTGCCGAC ATTGCCGGAC AGTCCGCCGA 1101ACTCGGCTTG CAAAGTTATT TGGAATTTTT AGCGTTGGTC AGCATCAGCC 1151 TCGGCGTGCTGAACCTGCTG CCCGTCCCCG TTTTGGACGG CGGGCACCTC 1201 GTGTTTTATA CTGTCGAATGGATACGCGGC AAACCTTTGG GCGAACGTGT 1251 CCAAAACATC GGTTTGCGCT TCGGGCTCGCCCTGATGATG CTGATGATGG 1301 CGGCCGCCTT CTTCAACGAC GTTACCCGGC TGATCGGTTA GThis corresponds to the amino acid sequence <SEQ ID 1842; ORF 591.ng>:

g591.pep.. 1 LQTLLAFIFA ILILVSLHEF GHYIVARLCG VKVVRFSVGF GKPFFTRKRG 51DTEWCLAPIP LGGYVKMVDT REGEVSEADL PYAFDKQHPA KRIAIVAAGP 101 LTNLALAVLLYGLSFSFGVT ELRPYVGTVE PDTVAARTGF QSGDKIQSVN 151 GVSVQDWSSA QTEIVLNLEAGKVAVGVQTA SGAQTVRTID AAGTPEAGKI 201 AKNQGYIGLM PFKITTVAGG VEKGSPAEKAGLKPGDRLTA ADGKPIASWQ 251 EWANLTRQSP GKKITLTYER AGQTHTADIR PDTVEQPDHTLIGRVGLRPQ 301 PDRAWDAQIR RSYRPSVVRA FGMGWEKTVS HSWTTLKFFG KLISGNASVS351 HISGPLTIAD IAGQSAELGL QSYLEFLALV SISLGVLNLL PVPVLDGGHL 401VFYTVEWIRG KPLGERVQNI GLRFGLALMM LMMAAAFFND VTRLIG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1843>:

m591.seq 1 TTGCACACCC TTCTAGCTTT TATCTTCGCC ATCCTGATTT TGGTCAGCCT 51GCACGAGTTC GGACACTACA TCGTTGCCAG ATTGTGCGGC GTCAAAGTCG 101 TACGCTTTTCCGTCGGCTTC GGCAAACCGT TTTTCACCCG AAAGCGCGGC 151 GACACCGAAT GGTGCCTCGCCCCGATTCCG TTGGGCGGTT ACGTCAAAAT 201 GGTCGATACG CGCGAAGGCG AAGTATCAGAAGCCGATTTA CCCTACGCTT 251 TTGACAAACA ACACCCCGCC AAGCGCATCG CCATCGTCGCCGCCGGCCCA 301 CTGACCAACC TCGCACTGGC GGTTTTGCTG TACGGACTGA GCTTTTCCTT351 CGGCGTAACC GAACTGCGCC CCTACGTCGG CACAGTCGAA CCCGACACCA 401TTGCCGCCCG CGCCGGCTTC CAAAGCGGCG ACAAAATACA ATCCGTCAAC 451 GGCACACCCGTTGCAGATTG GGGCAGCGCG CAAACCGAAA TCGTCCTCAA 501 CCTCGAAGCC GGCAAAGTCGCCGTCGGCGT TCAGACGGCA TCGGGCGCGC 551 AAACCGTCCG CACCATCGAT GCCGCAGGCACGCCGGAAGC CGGTAAAATC 601 GCAAAAAACC AAGGCTACAT CGGACTGATG CCCTTTAAAATCACAACCGT 651 TGCCGGCGGC GTGGAAAAAG GCAGCCCCGC CGAAAAAGCA GGCCTGAAAC701 CGGGCGACAG GCTGACTGCC GCCGACGGCA AACCCATCGC CTCATGGCAA 751GAATGGGCAA ACCTGACCCG CCAAAGCCCC GGCAAAAAAA TCACCCTGAA 801 CTACGAACGCGCCGGACAAA CCCATACCGC CGACATCCGC CCCGATACTG 851 TCGAACAGTC CGACCACACCCTGATCGGGC GCGTCGGCCT CCGTCCGCAG 901 CCGGACAGGG CGTGGGACGC GCAAATCCGCCGCAGCTACC GTCCGTCTGT 951 TGTCCGCGCA TTCGGCATGG GCTGGGAAAA AACCGTTTCCCACTCGTGGA 1001 CAACCCTCAA ATTTTTCGGC AAACTAATCA GCGGCAACGC CTCCGTCAGC1051 CATATTTCCG GGCCGCTGAC CATTGCCGAC ATTGCCGGAC AGTCCGCCGA 1101ACTCGGCTTG CAAAGTTATT TGGAATTTTT AGCACTGGTC AGCATCAGCC 1151 TCGGCGTGCTGAACCTACTG CCCGTCCCTG TTTTGGACGG CGGGCACCTC 1201 GTGTTTTATA CTGCCGAATGGATACGCGGC AAACCTTTGG GCGAACGCGT 1251 CCAAAACATC GGTTTGCGCT TCGGGCTCGCCCTCATGATG CTGATGATGG 1301 CGGTCGCCTT CTTCAACGAC GTTACCCGGC TGCTCGGTTA GThis corresponds to the amino acid sequence <SEQ ID 1844; ORF 591>:

m591.pep.. 1 LHTLLAFIFA ILILVSLHEF GHYIVARLCG VKVVRFSVGF GKPFFTRKRG 51DTEWCLAPIP LGGYVKMVDT REGEVSEADL PYAFDKQHPA KRIAIVAAGP 101 LTNLALAVLLYGLSFSFGVT ELRPYVGTVE PDTIAARAGF QSGDKIQSVN 151 GTPVADWGSA QTEIVLNLEAGKVAVGVQTA SGAQTVRTID AAGTPEAGKI 201 AKNQGYIGLM PFKITTVAGG VEKGSPAEKAGLKPGDRLTA ADGKPIASWQ 251 EWANLTRQSP GKKITLNYER AGQTHTADIR PDTVEQSDHTLIGRVGLRPQ 301 PDRAWDAQIR RSYRPSVVRA FGMGWEKTVS HSWTTLKFFG KLISGNASVS351 HISGPLTIAD IAGQSAELGL QSYLEFLALV SISLGVLNLL PVPVLDGGHL 401VFYTAEWIRG KPLGERVQNI GLRFGLALMM LMMAVAFFND VTRLLG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m591/g591 97.3% identity in 446 aa overlap        10        20        30        40        50        60 m591.pepLHTLLAFIFAILILVSLHEFGHYIVARLCGVKVVRFSVGFGKPFFTRKRGDTEWCLAPIP|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g591LQTLLAFIFAILILVSLHEFGHYIVARLCGVKVVRFSVGFGKPFFTRKRGDTEWCLAPIP        10        20        30        40        50        60        70        80        90       100       110       120 m591.pepLGGYVKMVDTREGEVSEADLPYAFDKQHPAKRIAIVAAGPLTNLALAVLLYGLSFSFGVT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g591LGGYVKMVDTREGEVSEADLPYAFDKQHPAKRIAIVAAGPLTNLALAVLLYGLSFSFGVT        70        80        90       100       110       120       130       140       150       160       170       180 m591.pepELRPYVGTVEPDTIAARAGFQSGDKIQSVNGTPVADWGSAQTEIVLNLEAGKVAVGVQTA|||||||||||||:|||:|||||||||||||: | ||:|||||||||||||||||||||| g591ELRPYVGTVEPDTVAARTGFQSGDKIQSVNGVSVQDWSSAQTEIVLNLEAGKVAVGVQTA       130       140       150       160       170       180       190       200       210       220       230       240 m591.pepSGAQTVRTIDAAGTPEAGKIAKNQGYIGLMPFKITTVAGGVEKGSPAEKAGLKPGDRLTA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g591SGAQTVRTIDAAGTPEAGKIAKNQGYIGLMPFKITTVAGGVEKGSPAEKAGLKPGDRLTA       190       200       210       220       230       240       250       260       270       280       290       300 m591.pepADGKPIASWQEWANLTRQSPGKKITLNYERAGQTHTADIRPDTVEQSDHTLIGRVGLRPQ||||||||||||||||||||||||||:||||||||||||||||||| ||||||||||||| g591ADGKPIASWQEWANLTRQSPGKKITLTYERAGQTHTADIRPDTVEQPDHTLIGRVGLRPQ       250       260       270       280       290       300       310       320       330       340       350       360 m591.pepPDRAWDAQIRRSYRPSVVRAFGMGWEKTVSHSWTTLKFFGKLISGNASVSHISGPLTIAD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g591PDRAWDAQIRRSYRPSVVRAFGMGWEKTVSHSWTTLKFFGKLISGNASVSHISGPLTIAD       310       320       330       340       350       360       370       380       390       400       410       420 m591.pepIAGQSAELGLQSYLEFLALVSISLGVLNLLPVPVLDGGHLVFYTAEWIRGKPLGERVQNI||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||| g591IAGQSAELGLQSYLEFLALVSISLGVLNLLPVPVLDGGHLVFYTVEWIRGKPLGERVQNI       370       380       390       400       410       420       430       440 m591.pep GLRFGLALMMLMMAVAFFNDVTRLLGX||||||||||||||:|||||||||:|| g591 GLRFGLALMMLMMAAAFFNDVTRLIGX       430       440The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1845>:

a591.seq 1 TTGCACACCC TTCTAGCTTT TATCTTCGCC ATCCTGATTT TGGTCAGCCT 51GCACGAATTC GGACACTACA TCGTCGCCAG ATTGTGCGGC GTCAAGGTTG 101 TGCGTTTTTCCGTCGGCTTC GGCAAACCGT TTTTCACCCG AAAGCGCGGC 151 GACACCGAAT GGTGCCTCGCCCCGATTCCG TTGGGCGGTT ACGTCAAAAT 201 GGTCGACACG CGCGAAGGCG AAGTATCAGAAGCCGATTTA CCCTACGCTT 251 TTGACAAACA ACACCCCGCC AAGCGCATCG CCATCGTCGCCGCCGGCCCG 301 CTGACCAACC TCGCACTGGC GGTTTTGCTG TACGGACTGA GCTTTTCCTT351 CGGCGTTACC GAACTGCGCC CCTATGTCGG CACAGTCGAA CCCGACACCA 401TTGCCGCCCG CGCCGGCTTC CAAAGCGGCG ACAAAATACA ATCCGTCAAC 451 GGCACACCCGTTGCAGATTG GGGCAGCGCG CAAACCGAAA TCGTCCTCAA 501 CCTCGAAGCC GGCAAAGTCGCCGTCGGCGT TCAGACGGCA TCGGGCGCGC 551 AAACCGTCCG CACCATCGAT GCCGCAGGCACGCCGGAAGC CGGTAAAATC 601 GCAAAAAACC AAGGCTACAT CGGACTGATG CCCTTTAAAATCACAACCGT 651 TGCCGGCGGC GTGGAAAAAG GCAGCCCCGC CGAAAAAGCA GGCCTGAAAC701 CGGGCGACAG GCTGACTGCC GCCGACGGCA AACCCATCGC CTCATGGCAA 751GAATGGGCAA ACCTGACCCG CCAAAGCCCC GGCAAAAAAA TCACCCTGAC 801 CTACGAACGCGCCGGACAAA CCCATACCGC CGACATCCGC CCCGATACTG 851 TCGAACAGCC CGACCACACCCTGATCGGGC GCGTCGGCCT CCGTCCGCAG 901 CCGGACAGGG CGTGGGACGC GCAAATCCGCCGCAGCTACC GTCCGTCTGT 951 TGTCCGCGCA TTCGGCATGG GCTGGGAAAA AACCGTTTCCCACTCGTGGA 1001 CAACCCTCAA ATTTTTCGGC AAACTAATCA GCGGCAACGC CTCCGTCAGC1051 CATATTTCCG GTCCGCTGAC CATTGCCGAT ATTGCCGGAC AGTCCGCCGA 1101ACTCGGCTTG CAAAGTTATT TGGAATTTTT GGCACTGGTC AGCATCAGCC 1151 TCGGCGTGCTGAACCTGCTG CCCGTCCCCG TTTTGGACGG CGGCCACCTC 1201 GTGTTTTATA CTGCCGAATGGATACGCGGC AAACCTTTGG GCGAACGCGT 1251 CCAAAACATC GGTTTGCGCT TCGGGCTTGCCCTCATGATG CTGATGATGG 1301 CGGTCGCCTT CTTCAACGAC GTTACCCGGC TGCTCGGTTA GThis corresponds to the amino acid sequence <SEQ ID 1846; ORF 591.a>:

a591.pep 1 LHTLLAFIFA ILILVSLHEF GHYIVARLCG VKVVRFSVGF GKPFFTRKRG 51DTEWCLAPIP LGGYVKMVDT REGEVSEADL PYAFDKQHPA KRIAIVAAGP 101 LTNLALAVLLYGLSFSFGVT ELRPYVGTVE PDTIAARAGF QSGDKIQSVN 151 GTPVADWGSA QTEIVLNLEAGKVAVGVQTA SGAQTVRTID AAGTPEAGKI 201 AKNQGYIGLM PFKITTVAGG VEKGSPAEKAGLKPGDRLTA ADGKPIASWQ 251 EWANLTRQSP GKKITLTYER AGQTHTADIR PDTVEQPDHTLIGRVGLRPQ 301 PDRAWDAQIR RSYRPSVVRA FGMGWEKTVS HSWTTLKFFG KLISGNASVS351 HISGPLTIAD IAGQSAELGL QSYLEFLALV SISLGVLNLL PVPVLDGGHL 401VFYTAEWIRG KPLGERVQNI GLRFGLALMM LMMAVAFFND VTRLLG* m591/a591 99.6%identity in 446 aa overlap        10        20        30        40        50        60 m591.pepLHTLLAFIFAILILVSLHEFGHYIVARLCGVKVVRFSVGFGKPFFTRKRGDTEWCLAPIP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a591LHTLLAFIFAILILVSLHEFGHYIVARLCGVKVVRFSVGFGKPFFTRKRGDTEWCLAPIP        10        20        30        40        50        60        70        80        90       100       110       120 m591.pepLGGYVKMVDTREGEVSEADLPYAFDKQHPAKRIAIVAAGPLTNLALAVLLYGLSFSFGVT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a591LGGYVKMVDTREGEVSEADLPYAFDKQHPAKRIAIVAAGPLTNLALAVLLYGLSFSFGVT        70        80        90       100       110       120       130       140       150       160       170       180 m591.pepELRPYVGTVEPDTIAARAGFQSGDKIQSVNGTPVADWGSAQTEIVLNLEAGKVAVGVQTA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a591ELRPYVGTVEPDTIAARAGFQSGDKIQSVNGTPVADWGSAQTEIVLNLEAGKVAVGVQTA       130       140       150       160       170       180       190       200       210       220       230       240 m591.pepSGAQTVRTIDAAGTPEAGKIAKNQGYIGLMPFKITTVAGGVEKGSPAEKAGLKPGDRLTA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a591SGAQTVRTIDAAGTPEAGKIAKNQGYIGLMPFKITTVAGGVEKGSPAEKAGLKPGDRLTA       190       200       210       220       230       240       250       260       270       280       290       300 m591.pepADGKPIASWQEWANLTRQSPGKKITLNYERAGQTHTADIRPDTVEQSDHTLIGRVGLRPQ||||||||||||||||||||||||||:|||||||||||||||||||′||||||||||||| a591ADGKPIASWQEWANLTRQSPGKKITLTYERAGQTHTADIRPDTVEQPDHTLIGRVGLRPQ       250       260       270       280       290       300       310       320       330       340       350       360 m591.pepPDRAWDAQIRRSYRPSVVRAFGMGWEKTVSHSWTTLKFFGKLISGNASVSHISGPLTIAD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a591PDRAWDAQIRRSYRPSVVRAFGMGWEKTVSHSWTTLKFFGKLISGNASVSHISGPLTIAD       310       320       330       340       350       360       370       380       390       400       410       420 m591.pepIAGQSAELGLQSYLEFLALVSISLGVLNLLPVPVLDGGHLVFYTAEWIRGKPLGERVQNI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a591IAGQSAELGLQSYLEFLALVSISLGVLNLLPVPVLDGGHLVFYTAEWIRGKPLGERVQNI       370       380       390       400       410       420       430       440 m591.pep GLRFGLALMMLMMAVAFFNDVTRLLGX||||||||||||||||||||||||||| a591 GLRFGLALMMLMMAVAFFNDVTRLLGX       430       440The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1847>:

g592.seq.. 1 atgattccgg acgtgttcgg tcagattttt tcgggcgcgt tcaaattcga 51cgcggcagca ggcggcttac tcggcggtct gatttcgcaa acgatgatga 101 tgggcatcaaacgcggcctg tattccaacg aggcgggtat gggttccgcg 151 ccgaacgccg ccgccgccgccgaagtgaaa caccctgttt cgcaaggtat 201 gattcaaatg ctgggcgtgt ttgtcgataccatcatcgtt tgttcttgca 251 ccgccttcat catcttgatt taccaacagc cttatggcgatttgagcggt 301 gcggcgctga cgcaggcggc gattgtcagc caagtggggc aatggggcgc351 gggtttcctc gccgtcatcc tgtttatgtt tgccttttcc accgttatcg 401gcaactatgc ctatgccgag tccaacgtcc aattcatcaa aagccattgg 451 ctgattaccgccgttttccg tatgctggtt ttggcgtggg tctatttcgg 501 cgcggttgcc aatgtgcctttggtctggga tatggcggat atggcgatgg 551 gcatcatggc gtggatcaac ctcgtcgccatcctgctgct ctcgccattg 601 gcgtttatgc tgctgcgcga ttacaccgcc aagctgaaaatgggcaaaga 651 ccccgagttc aaactttccg aacatccggg cctgaaacgc cgcatcaaat701 ccgatgtttg gtaaThis corresponds to the amino acid sequence <SEQ ID 1848; ORF 592.ng>:

g592.pep .. 1 MIPDVFGQIF SGAFKFDAAA GGLLGGLISQ TMMMGIKRGL YSNEAGMGSA 51PNAAAAAEVK HPVSQGMIQM LGVFVDTIIV CSCTAFIILI YQQPYGDLSG 101 AALTQAAIVSQVGQWGAGFL AVILFMFAFS TVIGNYAYAE SNVQFIKSHW 151LITAVFRMLV LAWVYFGAVA NVPLVWDMAD MAMGIMAWIN LVAILLLSPL 201 AFMLLRDYTAKLKMGKDPEF KLSEHPGLKR RIKSDVW*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1849>:

m592.seq .. 1 ATGATTCCGG ACGTGTTCGG TCAGATTTTT TCGGGCGCGT TCAAATTCGA 51CGCGGCAGCA GGCGGCTTAC TCGGCGGTCT GATTTCGCAA ACGATGATGA 101 TGGGCATCAAACGCGGCCTG TATTCCAACG AGGCGGGTAT GGGTTCCGCG 151 CCGAACGCCG CCGCCGCCGCCGAAGTGAAA CACCCTGTTT CGCAAGGTAT 201 GATTCAAATG CTGGGCGTGT TTGTCGATACCATCATCGTT TGTTCTTGCA 251 CCGCCTTCAT CATCTTGATT TACCAACAGC CTTACGGCGATTTGAGCGGT 301 GCGGCGCTGA CGCAGGCGGC GATTGTCAGC CAAGTGGGGC AATGGGGCGC351 GGGCTTCCTC GCCGTCATCC TGTTTATGTT TGCCTTTTCC ACCGTTATCG 401GCAACTATGC CTATGCCGAG TCCAACGTCC AATTCATCAA AAGCCATTGG 451 CTGATTACCGCCGTTTTCCG TATGCTGGTT TTGGCGTGGG TCTATTTCGG 501 CGCGGTTGCC AATGTGCCTTTGGTCTGGGA TATGGCGGAT ATGGCGATGG 551 GCATTATGGC GTGGATCAAC CTTGTCGCCATCCTGCTGCT CTCGCCCTTG 601 GCGTTTATGC TGCTGCGCGA TTACACCGCC AAGCTGAAAATGGGCAAAGA 651 CCCCGAGTTC AAACTTTCCG AACATCCGGG CCTGAAACGC CGTATCAAAT701 CCGACGTTTG GTAAThis corresponds to the amino acid sequence <SEQ ID 1850; ORF 592>:

m592.pep .. 1 MIPDVFGQIF SGAFKFDAAA GGLLGGLISQ TMMMGIKRGL YSNEAGMGSA 51PNAAAAAEVK HPVSQGMIQM LGVFVDTIIV CSCTAFIILI YQQPYGDLSG 101 AALTQAAIVSQVGQWGAGFL AVILFMFAFS TVIGNYAYAE SNVQFIKSHW 151LITAVFRMLV LAWVYFGAVA NVPLVWDMAD MAMGIMAWIN LVAILLLSPL 201 AFMLLRDYTAKLKMGKDPEF KLSEHPGLKR RIKSDVW* m592/g592 100.0% identity in 237 aaoverlap         10        20        30        40        50        60m592.pep MIPDVFGQIFSGAFKFDAAAGGLLGGLISQLMMMGIKRGLYSNEAGMGSAPNAAAAAEVK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g592MIPDVFGQIFSGAFKFDAAAGGLLGGLISQLMMMGIKRGLYSNEAGMGSAPNAAAAAEVK        10        20        30        40        50        60        70        80        90       100       110       120 m592.pepHPVSQGMIQMLGVFVDTIIVCSCTAFIILIYQQPYGDLSGAALTQAAIVSQVGQWGAGFL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g592HPVSQGMIQMLGVFVDTIIVCSCTAFIILIYQQPYGDLSGAALTQAAIVSQVGQWGAGFL        70        80        90       100       110       120       130       140       150       160       170       180 m592.pepAVILFMFAFSTVIGNYAYAESNVQFIKSHWLITAVFRMLVLAWVYFGAVANVPLVWDMAD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g592AVILFMFAFSTVIGNYAYAESNVQFIKSHWLITAVFRMLVLAWVYFGAVANVPLVWDMAD       130       140       150       160       170       180       190       200       210       220       230 m592.pepMAMGIMAWINLVAILLLSPLAFMLLRDYTAKLKMGKDPEFKLSEHPGLKRRIKSDVWX|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g592MAMGIMAWINLVAILLLSPLAFMLLRDYTAKLKMGKDPEFKLSEHPGLKRRIKSDVWX       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1851>:

a592.seq 1 ATGATTCCGG ACGTGTTCGG TCAGATTTTT TCGGGCGCGT TCAAATTCGA 51CGCGGCAGCA GGCGGCTTAC TCGGCGGTCT GATTTCGCAA ACGATGATGA 101 TGGGCATCAAACGCGGCCTG TATTCCAACG AGGCGGGTAT GGGTTCCGCG 151 CCGAACGCCG CCGCCGCCGCCGAAGTGAAA CACCCTGTTT CGCAAGGTAT 201 GATTCAAATG CTGGGCGTGT TTGTCGATACCATCATCGTT TGTTCTTGCA 251 CCGCCTTCAT CATCTTGATT TACCAACAGC CTTACGGCGATTTGAGCGGT 301 GCGGCGCTGA CGCAGGCGGC GATTGTCAGC CAAGTGGGGC AATGGGGCGC351 GGGCTTCCTC GCCGTCATCC TGTTTATGTT TGCCTTTTCC ACCGTTATCG 401GCAACTATGC CTATGCCGAG TCCAACGTCC AATTCATCAA AAGCCATTGG 451 CTGATTACCGCCGTTTTCCG TATGCTGGTT TTGGCGTGGG TCTATTTCGG 501 CGCGGTTGCC AATGTGCCTTTGGTCTGGGA TATGGCGGAT ATGGCGATGG 551 GCATTATGGC GTGGATCAAC CTTGTCGCCATCCTGCTGCT CTCGCCCTTG 601 GCGTTTATGC TGCTGCGCGA TTACACCGCC AAGCTGAAAATGGGCAAAGA 651 CCCCGAGTTC AAACTTTCCG AACATCCGGG CCTGAAACGC CGTATCAAAT701 CCGACGTTTG GTAAThis corresponds to the amino acid sequence <SEQ ID 1852; ORF 592.a>:

a592.pep 1 MIPDVFGQIF SGAFKFDAAA GGLLGGLISQ TMMMGIKRGL YSNEAGMGSA 51PNAAAAAEVK HPVSQGMIQM LGVFVDTIIV CSCTAFIILI YQQPYGDLSG 101 AALTQAAIVSQVGQWGAGFL AVILFMFAFS TVIGNYAYAE SNVQFIKSHW 151LITAVFRMLV LAWVYFGAVA NVPLVWDMAD MAMGIMAWIN LVAILLLSPL 201 AFMLLRDYTAKLKMGKDPEF KLSEHPGLKR RIKSDVW* m592/a592 100.0% identity in 237 aaoverlap         10        20        30        40        50        60m592.pep MIPDVFGQIFSGAFKFDAAAGGLLGGLISQTMMMGIKRGLYSNEAGMGSAPNAAAAAEVK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a592MIPDVFGQIFSGAFKFDAAAGGLLGGLISQTMMMGIKRGLYSNEAGMGSAPNAAAAAEVK        10        20        30        40        50        60        70        80        90       100       110       120 m592.pepHPVSQGMIQMLGVFVDTIIVCSCTAFIILIYQQPYGDLSGAALTQAAIVSQVGQWGAGFL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a592HPVSQGMIQMLGVFVDTIIVCSCTAFIILIYQQPYGDLSGAALTQAAIVSQVGQWGAGFL        70        80        90       100       110       120       130       140       150       160       170       180 m592.pepAVILFMFAFSTVIGNYAYAESNVQFIKSHWLITAVFRMLVLAWVYFGAVANVPLVWDMAD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a592AVILFMFAFSTVIGNYAYAESNVQFIKSHWLITAVFRMLVLAWVYFGAVANVPLVWDMAD       130       140       150       160       170       180       190       200       210       220       230 m592.pepMAMGIMAWINLVAILLLSPLAFMLLRDYTAKLKMGKDPEFKLSEHPGLKRRIKSDVWX|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a592MAMGIMAWINLVAILLLSPLAFMLLRDYTAKLKMGKDPEFKLSEHPGLKRRIKSDVWX       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1853>:

g593.seq.. 1 atgcttgaac tgaacggact ctgcaaatgc ttcggcggca aaacggtcgc 51cgacaacatc tgcctgactg tcgggcgcgg caaaatactc gccgtactgg 101 ggcggtcgggctgcggcaaa tccaccctgc tgaatatgat tgcgggcatc 151 gtccggccgg acggcggcgaaattcggctg aacggggaaa acattacctg 201 tatgccgccc gaaaaacgcc gtatctcgctgatgtttcaa gattacgcgc 251 tgtttcccca tatgagtgcg ctggaaaata cggcattcggtttgaaaatg 301 caaaaaatgc cgaaagccga agccgaacgc ctcgccttgt cggcacttgc351 cgaagtcggg ctggaaaacg aggcgcaccg caagcctgaa aaactttccg 401gaggcgagaa gcaacggttg gcactggcgc gcgctttggt tgtccgccct 451 tccctgctgttgctggatga atcgttttcc agtttggaca cgcatttgcg 501 cgaccggctg cgccgtatgaccgccgaacg catccgcaag ggcggcatcc 551 ctgccgtttt ggtaacgcat tcgcccgaagaggcctgcac ggcggcggac 601 gaaatcgccg tcatgcacga ggggaaaatc cttcaatgcggtacgcccga 651 aaccttgatt caaacgcctg ccggcgtgca ggtcgcccgt ctgatggggc701 tgcccaatac cgacgatgac cgccatattc cgcaaaatgc cgtgtgcttg 751gacaatcatg gaacggaatg ccgtctgctg tccctcgtcc gcctgcccga 801 ctcgctccggctttccgccg tccatcccga acacggcgag ctgaccttaa 851 acctgactgt cggacaacatacggacggta tttccggaaa cggtacggtc 901 cgcatccgcg tcgatgaagg gcgtatcgtccgtttccgat gaThis corresponds to the amino acid sequence <SEQ ID 1854; ORF 593.ng>:

g593.pep.. 1 MLELNGLCKC FGGKTVADNI CLTVGRGKIL AVLGRSGCGK STLLNMIAGI 51VRPDGGEIRL NGENITCMPP EKRRISLMFQ DYALFPHMSA LENTAFGLKM 101 QKMPKAEAERLALSALAEVG LENEAHRKPE KLSGGEKQRL ALARALVVRP 151 SLLLLDESFS SLDTHLRDRLRRMTAERIRK GGIPAVLVTH SPEEACTAAD 201 EIAVMHEGKI LQCGTPETLI QTPAGVQVARLMGLPNTDDD RHIPQNAVCL 251 DNHGTECRLL SLVRLPDSLR LSAVHPEHGE LTLNLTVGQHTDGISGNGTV 301 RIRVDEGRIV RFR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1855>:

m593.seq 1 ATGCTTGAAC TGAACGGACT CTGCAAACGC TTCGGCAATA AAACCGTCGC 51CGACAACATC TGCCTGACTG TCGGGCGCGG CAAAATACTC GCCGTTTTGG 101 GGCGGTCGGGCTGCGGAAAA TCCACCCTGC TGAATATAAT TGCGGGGATT 151 GTCCGGCCGG ACGGCGGGGAAATATGGCTG AACGGAGAAA ACATTACCCG 201 TATGCCGCCC GAAAAACGCC GTATCTCGCTGATGTTTCAA GATTACGCGC 251 TGTTTCCCCA TATGAGTGCG CTGGAAAATG CGGCATTCGGTTTGAAAATG 301 CAAAAAATGC CGAAAGCCGA AGCCGAACGC CTCGCCATGG CGGCACTTGC351 CGAAGTCGGA CTGGAAAACG AGGCGCACCG CAAGCCTGAA AAACTTTCCG 401GAGGCGAGAA GCAACGGCTG GCGTTGGCGC GCGCTTTGGT TGTCCGCCCT 451 TCCCTGCTGCTGTTGGACGA ATCGTTTTCC AGTTTGGACA CGCATTTGCG 501 CGGCACGCTG CGCCGTATGACTGCCGAACG TATCCGAAAC GGCGGCATCC 551 CTGCCGTTTT GGTAACGCAT TCGCCCGAAGAAGCCTGTAC GACGGCAGAC 601 GAAATCGCCG TGATGCATAA AGGGAGGATT CTACAATACGGTACGCCCGA 651 AACATTGGTC AAAACACCAT CCTGCGTGCA GGTCGCCCGA CTGATGGGTT701 TGCCCAATAC CGACGATAAC CGCCATATTC CGCAACATGC GGTGCGTTTC 751GACCAAGACG GCATGGAGTG CCGCGTATTA TCCCGTACCT GTTTGCCCGA 801 ATCGTTCAGCCTGTCCGTCC TCCATCCGGA ACACGGCATC CTGTGGCTGA 851 ACCTCGATAT GCGGCACGCCGGGGCGGTAT CGGGCAAGGA TACGGTACGC 901 ATCCATATCG AAGAACGGGA AATCGTCCGCTTCCGCTGAThis corresponds to the amino acid sequence <SEQ ID 1856; ORF 593>:

m593.pep .. 1 MLELNGLCKR FGNKTVADNI CLTVGRGKIL AVLGRSGCGK STLLNIIAGI 51VRPDGGEIWL NGENITRMPP EKRRISLMFQ DYALFPHMSA LENAAFGLKM 101 QKMPKAEAERLAMAALAEVG LENEAHRKPE KLSGGEKQRL ALARALVVRP 151 SLLLLDESFS SLDTHLRGTLRRMTAERIRN GGIPAVLVTH SPEEACTTAD 201 EIAVMHKGRI LQYGTPETLV KTPSCVQVARLMGLPNTDDN RHIPQHAVRF 251 DQDGMECRVL SRTCLPESFS LSVLHPEHGI LWLNLDMRHAGAVSGKDTVR 301 IHIEEREIVR FR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m593/g593 83.4% identity in 313 aa overlap          10        20        30        40        50        60 m593.pep  MLELNGLCKRFGNKTVADNICLTVGRGKILAVLGRSGCGKSTLLNIIAGIVRPDGGEIWL  ||||||||| ||:||||||||||||||||||||||||||||||||:|||||||||||| | g593  MLELNGLCKCFGGKTVADNICLTVGRGKILAVLGRSGCGKSTLLNMIAGIVRPDGGEIRL          10        20        30        40        50        60          70        80        90       100       110       120 m593.pep  NGENITRMPPEKRRISLMFQDYALFPHMSALENAAFGLKMQKMPKAEAERLAMAALAEVG  |||||| ||||||||||||||||||||||||||:||||||||||||||||||::|||||| g593  NGENITCMPPEKRRISLMFQDYALFPHMSALENTAFGLKMQKMPKAEAERLALSALAEVG          70        80        90       100       110       120         130       140       150       160       170       180 m593.pep  LENEAHRKPEKLSGGEKQRLALARALVVRPSLLLLDESFSSLDTHLRGTLRRMTAERIRN  ||||||||||||||||||||||||||||||||||||||||||||||| ||||||||||: g593  LENEAHRKPEKLSGGEKQRLALARALVVRPSLLLLDESFSSLDTHLRDRLRRMTAERIRK         130       140       150       160       170       180         190       200       210       220       230       240 m593.pep  GGIPAVLVTHSPEEACTTADEIAVMHKGRILQYGTPETLVKTPSCVQVARLMGLPNTDDN  |||||||||||||||||:||||||||:|:||| ||||||::||: ||||||||||||||: g593  GGIPAVLVTHSPEEACTAADEIAVMHEGKILQCGTPETLIQTPAGVQVARLMGLPNTDDD         190       200       210       220       230       240         250       260       270       280       290       299 m593.pep  RHIPQHAVRFDQDGMECRVLSRTCLPESFSLSVLHPEHGILWLNLDM-RHAGAVSGKDTV  |||||:|| :|: | |||:|| : ||:|: ||::||||| | ||| : :|: ::||: || g593  RHIPQNAVCLDNHGTECRLLSLVRLPDSLRLSAVHPEHGELTLNLTVGQHTDGISGNGTV         250       260       270       280       290       300300       310 m593.pep   RIHIEEREIVRFRX   ||:::| :|||||| g593  RIRVDEGRIVRFRX          310The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1857>:

a593.seq 1 ATGCTTGAAC TGAACGGACT CTGCAAACGC TTCGGCGGCA AAACGGTTGC 51CGACGATATC TGCCTGACTG TCGGGCGCGG CAAAATACTC GCCGTTTTGG 101 GGCGGTCGGGCTGCGGCAAA TCCACCCTGC TGAATATGAT TGCGGGCATC 151 GTCCGGCCGG ACGGCGGGGAAATATGGCTG AATGGGGAAA ACATTACCCG 201 TATGCCGCCC GAAAAACGCC GTATTTCGCTGATGTTTCAA GATTACGCGC 251 TGTTTCCCCA TATGAGTGCA CTGGAAAATG CGGCATTCGGTTTGAAAATG 301 CAAAAAATGC CGAAAGCCGA AGCCGAAAGC CTCGCCATGG CGGCACTTGC351 CGAAGTCGGA CTGGAAAACG AGGCGCACCG CAAGCCTGAN AAACTTTCCG 401GAGGCGAAAA GCAACGGTTG GCACTGGCGC GCGCTTTGGT TGTCCGCCCT 451 TCCCTGCTGCTGTTGGACGA ATCGTTTTCC AGTTTGGACA CGCATTTGCG 501 CGACCGGCTG CGCCGCATGACTGCCGAACG TATCCGCAAG GGCGGCATCC 551 CTGCCGTTTT GGTAACGCAT TCGCCCGAAGAGGCCTGCAC GGCGGCAGAC 601 GAAATCGCCG TCATGCACGA GGGGAAAATC CTTCAATGCGGTACGCCCGA 651 AACCTTGGTT CAAACGCCTG CCGGCGTGCA GGTCGCCCAT CTGATGGGGC701 TGCCCAATAC CGACGATGAC CGCCATATTC CGCAACATGC GGTGCGTTTC 751GACCAAGACG GCATGGAGTG CCGCGTATTA TCCCGTACCT GTTTGCCCGA 801 ATCGTTCAGCCTGTCCGTCC TCCATCCGGA ACACGGCATC CTGTGGCTGA 851 ACCTCGATAT GCCGCACGCCGGTGAAATAT CGGGAAACGA TACGGTACGC 901 ATCCATATCG AAGACAGGGA AATCGTCCGCTTCCGCTGAThis corresponds to the amino acid sequence <SEQ ID 1858; ORF 593.a>:

a593.pep 1 MLELNGLCKR FGGKTVADDI CLTVGRGKIL AVLGRSGCGK STLLNMIAGI 51VRPDGGEIWL NGENITRMPP EKRRISLMFQ DYALFPHMSA LENAAFGLKM 101 QKMPKAEAESLAMAALAEVG LENEAHRKPX KLSGGEKQRL ALARALVVRP 151 SLLLLDESFS SLDTHLRDRLRRMTAERIRK GGIPAVLVTH SPEEACTAAD 201 EIAVMHEGKI LQCGTPETLV QTPAGVQVAHLMGLPNTDDD RHIPQHAVRF 251 DQDGMECRVL SRTCLPESFS LSVLHPEHGI LWLNLDMPHAGEISGNDTVR 301 IHIEDREIVR FR* m593/a593 92.9% identity in 312 aa overlap        10        20        30        40        50        60 m593.pepMLELNGLCKRFGNKTVADNICLTVGRGKILAVLGRSGCGKSTLLNIIAGIVRPDGGEIWL||||||||||||:|||||:||||||||||||||||||||||||||:|||||||||||||| a593MLELNGLCKRFGGKTVADDICLTVGRGKILAVLGRSGCGKSTLLNMIAGIVRPDGGEIWL        10        20        30        40        50        60        70        80        90       100       110       120 m593.pepNGENITRMPPEKRRISLMFQDYALFPHMSALENAAFGLKMQKMPKAEAERLAMAALAEVG||||||||||||||||||||||||||||||||||||||||||||||||| |||||||||| a593NGENITRMPPEKRRISLMFQDYALFPHMSALENAAFGLKMQKMPKAEAESLAMAALAEVG        70        80        90       100       110       120       130       140       150       160       170       180 m593.pepLENEAHRKPEKLSGGEKQRLALARALVVRPSLLLLDESFSSLDTHLRGTLRRMTAERIRN||||||||| ||||||||||||||||||||||||||||||||||||| ||||||||||: a593LENEAHRKPXKLSGGEKQRLALARALVVRPSLLLLDESFSSLDTHLRDRLRRMTAERIRK       130       140       150       160       170       180       190       200       210       220       230       240 m593.pepGGIPAVLVTHSPEEACTTADEIAVMHKGRILQYGTPETLVKTPSCVQVARLMGLPNTDDN|||||||||||||||||:||||||||:|:||| |||||||:||: ||||:|||||||||: a593GGIPAVLVTHSPEEACTAADEIAVMHEGKILQCGTPETLVQTPAGVQVAHLMGLPNTDDD       190       200       210       220       230       240       250       260       270       280       290       300 m593.pepRHIPQHAVRFDQDGMECRVLSRTCLPESFSLSVLHPEHGILWLNLDMRHAGAVSGKDTVR||||||||||||||||||||||||||||||||||||||||||||||| ||| :||:|||| a593RHIPQHAVRFDQDGMECRVLSRTCLPESFSLSVLHPEHGILWLNLDMPHAGEISGNDTVR       250       260       270       280       290       300        310m593.pep IHIEEREIVRFRX ||||:|||||||| a593 IHIEDREIVRFRX        310The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1859>:

g594.seq.. 1 atgggtgcag ataccgatgg cgacaaggat gttcggctta atcgaacggg 51tctcgttttt agcatactcc ggctgctgtt ccgcatcgga attgggatcg 101 gtaagttcgccgttcaggcc tttcaggtct ttaagctgct gatctgtacg 151 gttgagcacc caaatcggtttgccttgcca ctcggcggtc agcagctgac 201 ccgcttcgat tttactgaca tccacctcgacggcagcacc ggaggccttg 251 gctttttccg aagggaaaaa actggccaca aacggcgttgccacacccaa 301 tgctgccact ccgcccgcgc cgcaggtcgc aagtgtcagg aaacggcggc351 ggccgttgtt gatttcttga ttatccatta ttcagtcgtc ctaatatttt 401gggaatgccg agccattaaa cattgcaatt ttacccagtt tgcagtgata 451 ctcaaagcattatttaaaat aaggtaaThis corresponds to the amino acid sequence <SEQ ID 1860; ORF 594.ng>:

g594.pep 1 MGADTDGDKD VRLNRTGLVF SILRLLFRIG IGIGKFAVQA FQVFKLLICT 51VEHPNRFALP LGGQQLTRFD FTDIHLDGST GGLGFFRREK TGHKRRCHTQ 101 CCHSARAAGRKCQETAAAVV DFLIIHYSVV LIFWECRAIK HCNFTQFAVI 151 LKALFKIR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1861>:

m594.seq 1 ATGGGTGCAG ATACCGATGG CGACAAGGAT GTTCGGCTTA ATCGAACGGG 51TCTCGTTTTT AGCATACTCC GGCTGCTGTT CCGCATCGGA ATTGGGATCG 101 GTAAGTTCGCCGTTCAGGCC TTTCAGGTCT TTAAGCTGCT GATCTGTACG 151 GTTGAGCACC CAAATCGGTTTGCCTTGCCA CTCGGCGGTC AGCAGCTGAC 201 CCGCTTCGAT TTTACTGACA TCCACCTCGACGGCAGCACC GGCGGCCTTG 251 GCTTTTTCCG AAGGGAAAAA ACTGGCCACA AACGGCGTTGCCACACCCAA 301 TGCTGCCACT CCGCCCGCGC CGCAGGTCGC GAGTGTCAGG AAACGGCGGC351 GGCCGTTGTT GATTTCTTGA TTATCCATTA TTCAGTCGTC CTAATATTTT 401GGGAATACCG AGCCATTAAA CGTTGCAATT TTACCCAGTT TGCAGTGATA 451 CTCAAAGCATTATTTAAAAT AAGGTAAThis corresponds to the amino acid sequence <SEQ ID 1862; ORF 594>:

m594.pep 1 MGADTDGDKD VRLNRTGLVF SILRLLFRIG IGIGKFAVQA FQVFKLLICT 51VEHPNRFALP LGGQQLTRFD FTDIHLDGST GGLGFFRREK TGHKRRCHTQ 101 CCHSARAAGRECQETAAAVV DFLIIHYSVV LIFWEYRAIK RCNFTQFAVI 151 LKALFKIR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m594/g594 98.1% identity in 158 aa overlap        10        20        30        40        50        60 m594.pepMGADTDGDKDVRLNRTGLVFSILRLLFRIGIGIGKFAVQAFQVFKLLICTVEHPNRFALP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g594MGADTDGDKDVRLNRTGLVFSILRLLFRIGIGIGKFAVQAFQVFKLLICTVEHPNRFALP        10        20        30        40        50        60        70        80        90       100       110       120 m594.pepLGGQQLTRFDFTDIHLDGSTGGLGFFRREKTGHKRRCHTQCCHSARAAGRECQETAAAVV||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| g594LGGQQLTRFDFTDIHLDGSTGGLGFFRREKTGHKRRCHTQCCHSARAAGRKCQETAAAVV        70        80        90       100       110       120       130       140       150      159 m594.pepDFLIIHYSVVLIFWEYRAIKRCNFTQFAVILKALFKIRX||||||||||||||| ||||:|||||||||||||||||| g594DFLIIHYSVVLIFWECRAIKHCNFTQFAVILKALFKIRX        130       140       150The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1863>:

a594.seq 1 ATGGGTGCAG ATACCGATGG CGACAAGGAT GTTCGGCTTA ATCGAACGGG 51TCTCGTTTTT AGCATACTCC GGCTGCTGTT CCGCATCGGA ATTGGGATCG 101 GTAAGTTCGCCGTTCAGGCC TTTCAGGTCT TTAAGCTGCT GATCTGTACG 151 GTTGAGCACC CAAATCGGTTTGCCTTGCCA CTCGGCGGTC AGCAACTGAC 201 CCGCTTCGAT TTTACTGACA TCCACCTCGACGGCAGCACC GGCGGCCTTG 251 GCTTTTTCCG AAGGGAAAAA ACTGGCCACA AACGGCGTTGCCACACCCAA 301 TGCTGCCACT CCGCCCGCGC CGCAGGTCGC GAGTGTCAGG AAACGGCGGC351 GGCCGTTGTT GATTTCTTGA TTATCCATTA TTCAGTCGTC CTAATATTTT 401GGGAATACCG AGCCATTAAA CGTTGCAATT TTACCCAGTT TGCAGTGATA 451 CTCAAAGCATTATTTAAAAT AAGGTAAThis corresponds to the amino acid sequence <SEQ ID 1864; ORF 594.a>:

a594.pep 1 MGADTDGDKD VRLNRTGLVF SILRLLFRIG IGIGKFAVQA FQVFKLLICT 51VEHPNRFALP LGGQQLTRFD FTDIHLDGST GGLGFFRREK TGHKRRCHTQ 101 CCHSARAAGRECQETAAAVV DFLIIHYSVV LIFWEYRAIK RCNFTQFAVI 151 LKALFKIR* m594/a594100.0% identity in 158 aa overlap        10        20        30        40        50        60 m594.pepMGADTDGDKDVRLNRTGLVFSILRLLFRIGIGIGKFAVQAFQVFKLLICTVEHPNRFALP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a594MGADTDGDKDVRLNRTGLVFSILRLLFRIGIGIGKFAVQAFQVFKLLICTVEHPNRFALP        10        20        30        40        50        60        70        80        90       100       110       120 m594.pepLGGQQLTRFDFTDIHLDGSTGGLGFFRREKTGHKRRCHTQCCHSARAAGRECQETAAAVV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a594LGGQQLTRFDFTDIHLDGSTGGLGFFRREKTGHKRRCHTQCCHSARAAGRECQETAAAVV        70        80        90       100       110       120       130       140       150      159 m594.pepDFLIIHYSVVLIFWEYRAIKRCNFTQFAVILKALFKIRX||||||||||||||||||||||||||||||||||||||| a594DFLIIHYSVVLIFWEYRAIKRCNFTQFAVILKALFKIRX        130       140       150The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1865>:

g595.seq.. 1 atgagaaaat tcaatttgac cgcattgtcc gtgatgcttg ccttgggttt 51gaccgcgtgc cagccgccgg aggcggagaa agccgcgccg gccgcgtccg 101 gtgagacccaatccgccaac gaaggcggtt cggtcggtat cgccgtcaac 151 gacaatgcct gcgaaccgatgaatctgacc gtgccgagcg gacaggttgt 201 gttcaatatt aaaaacaaca gcggccgcaagctcgaatgg gaaatcctga 251 agggcgtgat ggtggtggac gaacgcgaaa atatcgccccggggctttcc 301 gacaaaatga accgtaacct gctgccgggc gaatacgaaa tgacctgcgg351 ccttttgacc aatccgcgcg gcaagctggt ggtagccgac agcggcttta 401aagacaccgc caacgaagcg gatttggaaa aactgcccca accgctcgcc 451 gactataaagcctacgttca aggcgaggtt aaagagctgg cggcgaaaac 501 caaaaccttt accgaagccgtcaaagcagg cgacattgaa aaggcgaaat 551 ccctgtttgc cgccacccgc gtccattacgaacgcatcga accgattgcc 601 gagcttttca gcgaactcga ccccgtcatc gatgcgtgtgaagacgactt 651 caaagacggt gcgaaagatg ccgggtttac cggcttccac cgtatcgaac701 acgccctttg ggtggaaaaa gacgtatccg gcgtgaagga aaccgcggcc 751aaactgatga ccgatgtcga agccctgcaa aaagaaatcg acgcattggc 801 gttccctccgggcaaagtgg tcggcggcgc gtccgaactg attgaagaag 851 cggcgggcag taaaatcagcggcgaagaag accgttacag ccacaccgat 901 ttgagcgact tccaagctaa tgcggacggatctaaaaaaa tcgtcgattt 951 gttccgtccg ttgattgagg ccaaaaacaa agccttgttggaaaaaaccg 1001 ataccaactt caaacaggtc aacgaaattc tggcgaaata ccgcaccaaa1051 gacggttttg aaacctacga caagctgagc gaagccgacc gcaaagcatt 1101acaggctcct attaacgcgc ttgccgaaga ccttgcccaa cttcgcggca 1151 tactcggcttgaaataaThis corresponds to the amino acid sequence <SEQ ID 1866; ORF 595.ng>:

g595.pep .. 1 MRKFNLTALS VMLALGLTAC QPPEAEKAAP AASGETQSAN EGGSVGIAVN 51DNACEPMNLT VPSGQVVFNI KNNSGRKLEW EILKGVMVVD ERENIAPGLS 101 DKMNRNLLPGEYEMTCGLLT NPRGKLVVAD SGFKDTANEA DLEKLPQPLA 151 DYKAYVQGEV KELAAKTKTFTEAVKAGDIE KAKSLFAATR VHYERIEPIA 201 ELFSELDPVI DACEDDFKDG AKDAGFTGFHRIEHALWVEK DVSGVKETAA 251 KLMTDVEALQ KEIDALAFPP GKVVGGASEL IEEAAGSKISGEEDRYSHTD 301 LSDFQANADG SKKIVDLFRP LIEAKNKALL EKTDTNFKQV NEILAKYRTK351 DGFETYDKLS EADRKALQAP INALAEDLAQ LRGILGLK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1867>:

m595.seq 1 ATGAGAAAAT TCAATTTGAC CGCATTGTCC GTGATGCTTG CCTTAGGTTT 51GACCGCGTGC CAGCCGCCGG AGGCGGAGAA AGCTGCGCCG GCAGCGTCCG 101 GTGAGGCGCAAACCGCCAAC GAGGGCGGTT CGGTCAGTAT CGCCGTCAAC 151 GACAATGCCT GCGAACCGATGGAACTGACC GTGCCGAGCG GACAGGTTGT 201 GTTCAATATT AAAAACAACA GCGGCCGCAAGCTCGAATGG GAAATCCTGA 251 AAGGCGTGAT GGTGGTGGAC GAGCGCGAAA ACATCGCCCCCGGACTTTCC 301 GATAAAATGA CCGTCACCCT GTTGCCGGGC GAATACGAAA TGACTTGCGG351 TCTTTTGACC AATCCGCGCG GCAAGCTGGT GGTAACCGAC AGCGGCTTTA 401AAGACACCGC CAACGAAGCG GATTTGGAAA AACTGTCCCA ACCGCTCGCC 451 GACTATAAAGCCTACGTTCA AGGCGAGGTT AAAGAGCTGG TGGCGAAAAC 501 CAAAACTTTT ACCGAAGCCGTCAAAGCAGG CGACATTGAA AAGGCGAAAT 551 CCCTGTTTGC CGACACCCGC GTCCATTACGAACGCATCGA ACCGATTGCC 601 GAGCTTTTCA GCGAACTCGA CCCCGTCATC GATGCGCGTGAAGACGACTT 651 CAAAGACGGC GCGAAAGATG CCGGATTTAC CGGCTTTCAC CGTATCGAAT701 ACGCCCTTTG GGTGGAAAAA GACGTGTCCG GCGTGAAGGA AATTGCAGCG 751AAACTGATGA CCGATGTCGA AGCCCTGCAA AAAGAAATCG ACGCATTGGC 801 GTTTCCTCCGGGCAAGGTGG TCGGCGGCGC GTCCGAACTG ATTGAAGAAG 851 TGGCGGGCAG TAAAATCAGCGGCGAAGAAG ACCGGTACAG CCACACCGAT 901 TTGAGCGACT TCCAAGCCAA TGTGGACGGATCTAAAAAAA TCGTCGATTT 951 GTTCCGTCCG CTGATCGAGG CCAAAAACAA AGCCTTGTTGGAAAAAACCG 1001 ATACCAACTT CAAACAGGTC AACGAAATTC TGGCGAAATA CCGGACTAAA1051 GACGGTTTTG AAACCTACGA CAAGCTGGGC GAAGCCGACC GCAAAGCGTT 1101ACAGGCCTCT ATTAACGCGC TTGCCGAAGA CCTTGCCCAA CTTCGCGGCA 1151 TACTCGGCTTGAAATAAThis corresponds to the amino acid sequence <SEQ ID 1868; ORF 595>:

m595.pep 1 MRKFNLTALS VMLALGLTAC QPPEAEKAAP AASGEAQTAN EGGSVSIAVN 51DNACEPMELT VPSGQVVFNI KNNSGRKLEW EILKGVMVVD ERENIAPGLS 101 DKMTVTLLPGEYEMTCGLLT NPRGKLVVTD SGFKDTANEA DLEKLSQPLA 151 DYKAYVQGEV KELVAKTKTFTEAVKAGDIE KAKSLFADTR VHYERIEPIA 201 ELFSELDPVI DAREDDFKDG AKDAGFTGFHRIEYALWVEK DVSGVKEIAA 251 KLMTDVEALQ KEIDALAFPP GKVVGGASEL IEEVAGSKISGEEDRYSHTD 301 LSDFQANVDG SKKIVDLFRP LIEAKNKALL EKTDTNFKQV NEILAKYRTK351 DGFETYDKLG EADRKALQAS INALAEDLAQ LRGILGLK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m595/g595 95.4% identity in 388 aa overlap        10        20        30        40        50        60 m595.pepMRKFNLTALSVMLALGLTACQPPEAEKAAPAASGEAQTANEGGSVSIAVNDNACEPMELT|||||||||||||||||||||||||||||||||||:|:|||||||:|||||||||||:|| g595MRKFNLTALSVMLALGLTACQPPEAEKAAPAASGETQSANEGGSVGIAVNDNACEPMNLT        10        20        30        40        50        60        70        80        90       100       110       120 m595.pepVPSGQVVFNIKNNSGRKLEWEILKGVMVVDERENIAPGLSDKMTVTLLPGEYEMTCGLLT|||||||||||||||||||||||||||||||||||||||||||: :|||||||||||||| g595VPSGQVVFNIKNNSGRKLEWEILKGVMVVDERENIAPGLSDKMNRNLLPGEYEMTCGLLT        70        80        90       100       110       120       130       140       150       160       170       180 m595.pepNPRGKLVVTDSGFKDTANEADLEKLSQPLADYKAYVQGEVKELVAKTKTFTEAVKAGDIE||||||||:|||||||||||||||| |||||||||||||||||:|||||||||||||||| g595NPRGKLVVADSGFKDTANEADLEKLPQPLADYKAYVQGEVKELAAKTKTFTEAVKAGDIE       130       140       150       160       170       180       190       200       210       220       230       240 m595.pepKAKSLFADTRVHYERIEPIAELFSELDPVIDAREDDFKDGAKDAGFTGFHRIEYALWVEK||||||| |||||||||||||||||||||||| ||||||||||||||||||||:|||||| g595KAKSLFAATRVHYERIEPIAELFSELDPVIDACEDDFKDGAKDAGFTGFHRIEHALWVEK       190       200       210       220       230       240       250       260       270       280       290       300 m595.pepDVSGVKEIAAKLMTDVEALQKEIDALAFPPGKVVGGASELIEEVAGSKISGEEDRYSHTD||||||| |||||||||||||||||||||||||||||||||||:|||||||||||||||| g595DVSGVKETAAKLMTDVEALQKEIDALAFPPGKVVGGASELIEEAAGSKISGEEDRYSHTD       250       260       270       280       290       300       310       320       330       340       350       360 m595.pepLSDFQANVDGSKKIVDLFRPLIEAKNKALLEKTDTNFKQVNEILAKYRTKDGFETYDKLG|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||: g595LSDFQANADGSKKIVDLFRPLIEAKNKALLEKTDTNFKQVNEILAKYRTKDGFETYDKLS       310       320       330       340       350       360       370       380      389 m595.pep EADRKALQASINALAEDLAQLRGILGLKX||||||||| ||||||||||||||||||| g595 EADRKALQAPINALAEDLAQLRGILGLKX       370       380The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1869>:

a595.seq 1 ATGAGAAAAT TCAATTTGAC CGCATTGTCC GTGATGCTTG CCTTAGGTTT 51GACCGCGTGC CAGCCGCCGG AGGCGGAGAA AGCTGCGCCG GCAGCGTCCG 101 GTGAGGCGCAAACCGCCAAC GAGGGCGGTT CGGTCAGTAT CGCCGTCAAC 151 GACAATGCCT GCGAACCGATGGAACTGACC GTGCCGAGCG GACAGGTTGT 201 GTTCAATATT AAAAACAACA GCGGCCGCAAGCTCGAATGG GAAATCCTGA 251 AAGGCGTGAT GGTGGTGGAC GAGCGCGAAA ACATCGCCCCCGGACTTTCC 301 GATAAAATGA CCGTCACCCT GTTGCCGGGC GAATACGAAA TGACTTGCGG351 TCTTTTGACC AATCCGCGCG GCAAGCTGGT GGTAACCGAC AGCGGCTTTA 401AAGACACCGC CAACGAAGCG GATTTGGAAA AACTGTCCCA ACCGCTCGCC 451 GACTATAAAGCCTATGTTCA AGGCGAAGTC AAAGAGCTGG TGGCGAAAAC 501 CAAAACCTTT ACCGAAGCCGTCAAAGCAGG CGACATTGAA AAGGCGAAAT 551 CCCTGTTTGC CGACACCCGC GTCCATTACGAACGCATCGA ACCGATTGCC 601 GAGCTTTTCA GCGAACTCGA CCCCGTCATC GATGCGCGTGAAGACGACTT 651 CAAAGACGGC GCGAAAGATG CCGGATTTAC CGGCTTCCAC CGTATCGAAT701 ACGCCCTTTG GGTGGAAAAA GACGTGTCCG GCGTGAAGGA AATTGCAGCG 751AAACTGATGA CCGATGTCGA AGCCCTGCAA AAAGAAATCG ACGCATTGGC 801 GTTTCCTCCGGGCAAGGTGG TCGGCGGCGC GTCCGAACTG ATTGAAGAAG 851 TGGCGGGCAG TAAAATCAGCGGCGAAGAAG ACCGGTACAG CCACACCGAT 901 TTGAGCGACT TCCAAGCCAA TGTGGACGGATCGAAAAAAA TCGTCGATTT 951 GTTCCGTCCG TTGATCGAGA CCAAAAACAA AGCCTTGTTGGAAAAAACCG 1001 ATACCAACTT CAAACAGGTC AACGAAATTC TGGCGAAATA CCGGACTAAA1051 GACGGTTTTG AAACCTACGA CAAGCTGGGC GAAGCCGACC GCAAAGCGTT 1101ACAGGCCTCT ATTAACGCGC TTGCCGAAGA CCTTGCCCAA CTTCGCGGCA 1151 TACTCGGCTTGAAATAAThis corresponds to the amino acid sequence <SEQ ID 1870; ORF 595.a>:

a595.pep 1 MRKFNLTALS VMLALGLTAC QPPEAEKAAP AASGEAQTAN EGGSVSIAVN 51DNACEPMELT VPSGQVVFNI KNNSGRKLEW EILKGVMVVD ERENIAPGLS 101 DKMTVTLLPGEYEMTCGLLT NPRGKLVVTD SGFKDTANEA DLEKLSQPLA 151 DYKAYVQGEV KELVAKTKTFTEAVKAGDIE KAKSLFADTR VHYERIEPIA 201 ELFSELDPVI DAREDDFKDG AKDAGFTGFHRIEYALWVEK DVSGVKEIAA 251 KLMTDVEALQ KEIDALAFPP GKVVGGASEL IEEVAGSKISGEEDRYSHTD 301 LSDFQANVDG SKKIVDLFRP LIETKNKALL EKTDTNFKQV NEILAKYRTK351 DGFETYDKLG EADRKALQAS INALAEDLAQ LRGILGLK* m595/a595 99.7% identityin 388 aa overlap        10        20        30        40        50        60 m595.pepMRKFNLTALSVMLALGLTACQPPEAEKAAPAASGEAQTANEGGSVSIAVNDNACEPMELT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a595MRKFNLTALSVMLALGLTACQPPEAEKAAPAASGEAQTANEGGSVSIAVNDNACEPMELT        10        20        30        40        50        60        70        80        90       100       110       120 m595.pepVPSGQVVFNIKNNSGRKLEWEILKGVMVVDERENIAPGLSDKMTVTLLPGEYEMTCGLLT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a595VPSGQVVFNIKNNSGRKLEWEILKGVMVVDERENIAPGLSDKMTVTLLPGEYEMTCGLLT        70        80        90       100       110       120       130       140       150       160       170       180 m595.pepNPRGKLVVTDSGFKDTANEADLEKLSQPLADYKAYVQGEVKELVAKTKTFTEAVKAGDIE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a595NPRGKLVVTDSGFKDTANEADLEKLSQPLADYKAYVQGEVKELVAKTKTFTEAVKAGDIE       130       140       150       160       170       180       190       200       210       220       230       240 m595.pepKAKSLFADTRVHYERIEPIAELFSELDPVIDAREDDFKDGAKDAGFTGFHRIEYALWVEK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a595KAKSLFADTRVHYERIEPIAELFSELDPVIDAREDDFKDGAKDAGFTGFHRIEYALWVEK       190       200       210       220       230       240       250       260       270       280       290       300 m595.pepDVSGVKEIAAKLMTDVEALQKEIDALAFPPGKVVGGASELIEEVAGSKISGEEDRYSHTD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a595DVSGVKEIAAKLMTDVEALQKEIDALAFPPGKVVGGASELIEEVAGSKISGEEDRYSHTD       250       260       270       280       290       300       310       320       330       340       350       360 m595.pepLSDFQANVDGSKKIVDLFRPLIEAKNKALLEKTDTNFKQVNEILAKYRTKDGFETYDKLG|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| a595LSDFQANVDGSKKIVDLFRPLIETKNKALLEKTDTNFKQVNEILAKYRTKDGFETYDKLG       310       320       330       340       350       360       370       380      389 m595.pep EADRKALQASINALAEDLAQLRGILGLKX||||||||||||||||||||||||||||| a595 EADRKALQASINALAEDLAQLRGILGLKX       370       380The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1871>:

g596.seq. (partial). 1 ..atgctgctct tggacgagcc gaccaaccac ttggatgcggaatcggtgga 51   atggctggag caattcctcg tgcgcttccc cggcacagtg gtcgcggtaa101   cgcacgaccg ctacttcctc gacaacgccg ccgaatggat tttggaactc 151  gaccgcggac acggcattcc gtggaaaggc aattactcgt cttggctgga 201  gcagaaagaa aaacgcttgg aaaacgaggc gaaatccgaa gccgcgcgcg 251  tgaaggcgat gaagcaggaa ttggaatggg tgcgccaaaa tgccaaaggc 301  cgccaagcca agcccaaagc gcgtttggcg cgttttgaag aaatgagcaa 351  ctacgaatac caaaaacgca acgaaactca ggaaatcttt atccctgttg 401  ccgagcgttt gggtaacgaa gtgattgaat ttgtgaatgt ttccaaatcg 451  ttcggcgata aagtgctgat tgacggtttg agcttcaaag tgccggcggg 501  cgcgattgtc ggcatcatcg gcccgaacgg cgcgggtaaa tcgacgctgt 551  tcaaaatgat tgcgggcaaa gagcagcccg attcgggcga agtgaaaatc 601  gggcaaaccg tgaaaatgag cttgattgac caaagccgcg aaggtttgca 651  aaacgacaaa accgtgttcg acaacattgc cgaaggtcgc gatattttgc 701  aggtcggaca gtttgaaatc cccgcccgcc aatatttggg acgcttcaac 751  tttaaaggca gcgaccaaag caaaatcgca aggcagcttt ccggcggcga 801  acgcggccgt ctgcacttgg caaaaacctt gttgggcggc ggcaatgtgt 851  tgctgctgga cgaaccgtcc aacgatctcg acgtggaaac cctgcgcgcg 901  ttggaagacg cattgttgga atttgccggc agcgtgatgg tgatttcgca 951  cgaccgctgg tttctcgacc gcatagccac gcatatcttg gcgtgtgaag 1001  gcgactccaa atgggtgttc ttcgacggca actatcaaga atacgaagcc 1051  gacaagaaac gccgactcgg caaagaaggc gcgaaaccga aacgcatcaa 1101  atacaaaccg gtaacgcgtt aaThis corresponds to the amino acid sequence <SEQ ID 1872; ORF 596.ng>:

g596.pep (partial). 1 ..MLLLDEPTNH LDAESVEWLE QFLVRFPGTV VAVTHDRYFLDNAAEWILEL 51   DRGHGIPWKG NYSSWLEQKE KRLENEAKSE AARVKAMKQE LEWVRQNAKG101   RQAKPKARLA RFEEMSNYEY QKRNETQEIF IPVAERLGNE VIEFVNVSKS 151  FGDKVLIDGL SFKVPAGAIV GIIGPNGAGK STLFKMIAGK EQPDSGEVKI 201  GQTVKMSLID QSREGLQNDK TVFDNIAEGR DILQVGQFEI PARQYLGRFN 251  FKGSDQSKIA RQLSGGERGR LHLAKTLLGG GNVLLLDEPS NDLDVETLRA 301  LEDALLEFAG SVMVISHDRW FLDRIATHIL ACEGDSKWVF FDGNYQEYEA 351  DKKRRLGKEG AKPKRIKYKP VTR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1873>:

m596.seq.. 1 ATGTCCCAAC AATACGTCTA TTCTATGCTG CGCGTGAGCA AGGTTGTGCC 51GCCGCAGAAA ACCATCATTA AAGATATTTC CCTTTCTTTC TTCCCCGGCG 101 CGAAAATCGGCCTGCTCGGT TTGAACGGCG CGGGCAAGTC CACCGTGCTG 151 CGGATTATGG CGGGCGTGGATAAGGAATTT GAGGGCGAAG CCGTGCCGAT 201 GGGCGGCATC AAAATCGGCT ACCTGCCGCAAGAGCCTGAG CTTGATCCGG 251 AAAAAACCGT GCGCGAGGAA GTGGAAAGCG GTTTGGGCGAAGTGGCTGCC 301 GCGCAGAAAC GTTTGGAAGA AGTGTATGCC GAGTACGCCA ATCCTGATGC351 GGATTTTGAC GCGTTGGCAG AAGAGCAGGG CCGCTTGGAA GCGATTATTG 401CGGCAGGTTC GTCCACGGGC GGCGGTGCGG AACACGAATT GGAAATCGCC 451 GCCGACGCGCTGCGCCTGCC GGAATGGGAT GCCAAAATCG ATAATTTGTC 501 CGGCGGTGAA AAACGCCGCGTTGCCTTGTG CAAACTCTTG TTGAGCAAGC 551 CCGATATGCT TTTGCTGGAC GAGCCGACCAACCACTTGGA TGCGGAATCG 601 GTCGAGTGGC TGGAGCAATT TCTCGTGCGC TTCCCCGGCACAGTCGTTGC 651 GGTAACGCAC GACCGCTACT TCCTCGACAA CGCCGCCGAA TGGATTTTGG701 AACTCGACCG CGGCCATGGT ATTCCGTGGA AAGGCAATTA CTCGTCTTGG 751CTGGAGCAGA AAGAAAAACG CTTGGAAAAC GAGGCAAAAT CCGAAGCCGC 801 GCGCGTGAAGGCGATGAAGC AGGAATTGGA ATGGGTGCGC CAAAATGCCA 851 AAGGCCGCCA AGCCAAGTCCAAAGCGCGTT TGGCTCGTTT TGAAGAAATG 901 AGCAACTACG AATACCAAAA ACGCAATGAAACGCAGGAAA TCTTTATTCC 951 CGTTGCCGAG CGTTTGGGTA ACGAAGTGAT TGAATTTGTAAATGTTTCCA 1001 AATCGTTCGG CGATAAAGTG CTGATTGACG ATTTGAGCTT CAAAGTGCCT1051 GCGGGCGCGA TTGTCGGCAT CATCGGCCCG AACGGCGCGG GTAAATCTAC 1101GCTGTTCAAA ATGATTTCGG GCAAAGAGCA GCCTGATTCC GGCGAGGTGA 1151 AAATCGGACAAACCGTGAAA ATGAGCTTGA TTGACCAAAG CCGCGAAGGT 1201 TTGCAAAACG ACAAAACCGTGTTCGACAAC ATTGCCGAAG GCCGCGACAT 1251 TTTGCAGGTT GGTCAGTTTG AAATTCCCGCCCGCCAATAT TTGGGGCGTT 1301 TCAACTTCAA AGGCAGCGAC CAAAGCAAAA TTGCAGGTCAATTGTCTGGC 1351 GGCGAACGCG GTCGTCTGCA CTTGGCAAAA ACCTTGTTGA GCGGCGGCAA1401 TGTATTGCTG CTGGATGAAC CGTCTAACGA CCTTGACGTG GAAACCCTGC 1451GCGCGTTGGA AGACGCATTG TTGGAATTTG CCGGCAGCGT GATGGTGATT 1501 TCGCACGACCGTTGGTTCCT CGACCGCATC GCCACGCATA TCTTGGCGTG 1551 TGAAGGCGAC TCTAAATGGGTGTTCTTCGA CGGCAACTAT CAGGAATACG 1601 AAGCCGACAA GAAACGCCGT TTGGGCGAAGAAGGCGCGAA ACCGAAACGC 1651 ATCAAATACA AACCGGTAAC GCGTTAAThis corresponds to the amino acid sequence <SEQ ID 1874; ORF 596>:

m596.pep.. 1 MSQQYVYSML RVSKVVPPQK TIIKDISLSF FPGAKIGLLG LNGAGKSTVL 51RIMAGVDKEF EGEAVPMGGI KIGYLPQEPE LDPEKTVREE VESGLGEVAA 101 AQKRLEEVYAEYANPDADFD ALAEEQGRLE AIIAAGSSTG GGAEHELEIA 151 ADALRLPEWD AKIDNLSGGEKRRVALCKLL LSKPDMLLLD EPTNHLDAES 201 VEWLEQFLVR FPGTVVAVTH DRYFLDNAAEWILELDRGHG IPWKGNYSSW 251 LEQKEKRLEN EAKSEAARVK AMKQELEWVR QNAKGRQAKSKARLARFEEM 301 SNYEYQKRNE TQEIFIPVAE RLGNEVIEFV NVSKSFGDKV LIDDLSFKVP351 AGAIVGIIGP NGAGKSTLFK MISGKEQPDS GEVKIGQTVK MSLIDQSREG 401LQNDKTVFDN IAEGRDILQV GQFEIPARQY LGRFNFKGSD QSKIAGQLSG 451 GERGRLHLAKTLLSGGNVLL LDEPSNDLDV ETLRALEDAL LEFAGSVMVI 501 SHDRWFLDRI ATHILACEGDSKWVFFDGNY QEYEADKKRR LGEEGAKPKR 551 IKYKPVTR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m596 g596 98.4% identity in 373 aa overlap  160       170       180       190       200       210 m596.pepLPEWDAKIDNLSGGEKRRVALCKLLLSKPDMLLLDEPTNHLDAESVEWLEQFLVRFPGTV                              |||||||||||||||||||||||||||||| g596                              MLLLDEPTNHLDAESVEWLEQFLVRFPGTV                                      10        20        30  220       230       240       250       260       270 m596.pepVAVTHDRYFLDNAAEWILELDRGHGIPWKGNYSSWLEQKEKRLENEAKSEAARVKAMKQE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g596VAVTHDRYFLDNAAEWILELDRGHGIPWKGNYSSWLEQKEKRLENEAKSEAARVKAMKQE        40        50        60        70        80        90  280       290       300       310       320       330 m596.pepLEWVRQNAKGRQAKSKARLARFEEMSNYEYQKRNETQEIFIPVAERLGNEVIEFVNVSKS|||||||||||||| ||||||||||||||||||||||||||||||||||||||||||||| g596LEWVRQNAKGRQAKPKARLARFEEMSNYEYQKRNETQEIFIPVAERLGNEVIEFVNVSKS       100       110       120       130       140       150  340       350       360       370       380       390 m596.pepFGDKVLIDDLSFKVPAGAIVGIIGPNGAGKSTLFKMISGKEQPDSGEVKIGQTVKMSLID|||||||| ||||||||||||||||||||||||||||:|||||||||||||||||||||| g596FGDKVLIDGLSFKVPAGAIVGIIGPNGAGKSTLFKMIAGKEQPDSGEVKIGQTVKMSLID       160       170       180       190       200       210  400       410       420       430       440       450 m596.pepQSREGLQNDKTVFDNIAEGRDILQVGQFEIPARQYLGRFNFKGSDQSKIAGQLSGGERGR|||||||||||||||||||||||||||||||||||||||||||||||||| ||||||||| g596QSREGLQNDKIVFDNIAEGRDILQVGQFEIPARQYLGRFNFKGSDQSKIARQLSGGERGR       220       230       240       250       260       270  460       470       480       490       500       510 m596.pepLHLAKTLLSGGNVLLLDEPSNDLDVETLRALEDALLEFAGSVMVISHDRWFLDRIATHIL||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||| g596LHLAKTLLGGGNVLLLDEPSNDLDVETLRALEDALLEFAGSVMVISHDRWFLDRIATHIL       280       290       300       310       320       330  520       530       540       550      559 m596.pepACEGDSKWVFFDGNYQEYEADKKRRLGEEGAKPKRIKYKPVTRX|||||||||||||||||||||||||||:|||||||||||||||| g596ACEGDSKWVFFDGNYQEYEADKKRRLGKEGAKPKRIKYKPVTRX       340       350       360       370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1875>:

a596.seq 1 ATGTCCCAAC AATACGTCTA TTCTATGCTG CGCGTGAGCA AGGTTGTGCC 51GCCGCAGAAA ACCATCATTA AAGATATTTC CCTTTCTTTC TTCCCCGGCG 101 CGAAAATCGGTTTGCTCGGT TTGAACGGCG CGGGCAAGTC CACCGTGCTG 151 CGGATTATGG CGGGCGTGGATAAAGAATTT GAGGGCGAAG CCGTGCCGAT 201 GGGCGGTATT AAAATCGGCT ACCTGCCGCAAGAGCCTGAG CTTGATCCGG 251 AAAAAACCGT GCGTGAGGAA GTGGAAAGCG GTTTGGGCGAAGTGGCTGCC 301 GCGCAGAAAC GTTTGGAGGA AGTGTATGCC GAGTACGCCA ATCCCGATGC351 GGATTTTGAC GCGTTGGCGG AAGAGCAGGG GCGTTTGGAA GCGATTATTG 401CGGCGGGTTC GTCCACGGGC GGCGGTGCGG AACACGAATT GGAAATCGCT 451 GCCGACGCGCTGCGCCTGCC GGAATGGGAT GCCAAAATCG ATAATTTGTC 501 CGGCGGTGAA AAACGCCGCGTCGCTTTGTG CAAACTCTTG TTGAGCAAGC 551 CCGATATGCT TTTGCTGGAC GAGCCGACCAACCACTTGGA TGCGGAATCG 601 GTCGAGTGGC TGGAGCAATT TCTCGTGCGC TTCCCCGGTACAGTCGTTGC 651 CGTAACACAC GACCGCTACT TCCTCGACAA CGCCGCCGAA TGGATTTTGG701 AACTCGACCG CGGGCACGGT ATTCCGTGGA AAGGAAATTA CTCGTCTTGG 751TTGGAGCAGA AAGAAAAACG TTTGGAAAAC GAGGCGAAAT CCGAAGCCGC 801 GCGCGTGAAAGCGATGAAGC AGGAATTGGA ATGGGTGCGC CAAAATGCCA 851 AAGGCCGTCA AGCCAAGTCCAAAGCGCGTT TGGCGCGTTT TGAAGAAATG 901 AGCAACTATG AATACCAAAA ACGCAATGAAACGCAGGAAA TCTTCATTCC 951 CGTCGCCGAG CGTTTGGGTA ACGAAGTGAT TGAATTTGTGAATGTTTCCA 1001 AATCGTTCGG CGACAAAGTG CTGATTGACG ATTTGAGCTT CAAAGTGCCT1051 GCGGGCGCGA TTGTCGGCAT CATCGGTCCG AACGGCGCGG GTAAATCGAC 1101ACTGTTTAAA ATGATTGCGG GCAAAGAGCA GCCCGATTCC GGTGAAGTGA 1151 AAATCGGGCAAACCGTGAAA ATGAGCTTGA TTGACCAAAG CCGCGAAGGT 1201 TTGCAAAACG ACAAAACCGTGTTCGACAAC ATTGCCGAAG GTCGCGATAT 1251 TTTACAGGTC GGGCAGTTTG AAATCCCCGCCCGCCAATAT TTGGGACGCT 1301 TCAATTTCAA AGGCAGCGAC CAAAGCAAAA TCACGGGGCAGCTTTCCGGC 1351 GGCGAACGCG GACGTTTGCA CTTGGCAAAA ACCTTGTTGG GCGGTGGCAA1401 TGTGTTGCTG CTGGACGAAC CGTCCAACGA CCTCGACGTG GAAACCCTGC 1451GCGCGTTGGA AGACGCATTG CTGGAATTTG CCGGCAGCGT GATGGTGATT 1501 TCGCACGACCGCTGGTTCCT CGACCGTATT GCTACGCATA TCTTGGCTTG 1551 CGAAGGCGAC TCCAAATGGGTGTTCTTTGA CGGCAACTAT CAGGAATACG 1601 AAGCCGACAA GAAACGCCGA CTCGGCGAAGAAGGCACGAA ACCGAAACGC 1651 ATCAAATACA AACCGGTAAC GCGTTAAThis corresponds to the amino acid sequence <SEQ ID 1876; ORF 596.a>:

a596.pep 1 MSQQYVYSML RVSKVVPPQK TIIKDISLSF FPGAKIGLLG LNGAGKSTVL 51RIMAGVDKEF EGEAVPMGGI KIGYLPQEPE LDPEKTVREE VESGLGEVAA 101 AQKRLEEVYAEYANPDADFD ALAEEQGRLE AIIAAGSSTG GGAEHELEIA 151 ADALRLPEWD AKIDNLSGGEKRRVALCKLL LSKPDMLLLD EPTNHLDAES 201 VEWLEQFLVR FPGTVVAVTH DRYFLDNAAEWILELDRGHG IPWKGNYSSW 251 LEQKEKRLEN EAKSEAARVK AMKQELEWVR QNAKGRQAKSKARLARFEEM 301 SNYEYQKRNE TQEIFIPVAE RLGNEVIEFV NVSKSFGDKV LIDDLSFKVP351 AGAIVGIIGP NGAGKSTLFK MIAGKEQPDS GEVKIGQTVK MSLIDQSREG 401LQNDKTVFDN IAEGRDILQV GQFEIPARQY LGRFNFKGSD QSKITGQLSG 451 GERGRLHLAKTLLGGGNVLL LDEPSNDLDV ETLRALEDAL LEFAGSVMVI 501 SHDRWFLDRI ATHILACEGDSKWVFFDGNY QEYEADKKRR LGEEGTKPKR 551 IKYKPVTR* 9396/a596 99.3% identityin 558 aa overlap        10        20        30        40        50        60 m596.pepMSQQYVYSMLRVSKVVPPQKTIIKDISLSFFPGAKIGLLGLNGAGKSTVLRIMAGVDKEF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a596MSQQYVYSMLRVSKVVPPQKTIIKDISLSFFPGAKIGLLGLNGAGKSTVLRIMAGVDKEF        10        20        30        40        50        60        70        80        90       100       110       120 m596.pepEGEAVPMGGIKIGYLPQEPELDPEKTVREEVESGLGEVAAAQKRLEEVYAEYANPDADFD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a596EGEAVPMGGIKIGYLPQEPELDPEKTVREEVESGLGEVAAAQKRLEEVYAEYANPDADFD        70        80        90       100       110       120       130       140       150       160       170       180 m596.pepALAEEQGRLEAIIAAGSSTGGGAEHELEIAADALRLPEWDAKIDNLSGGEKRRVALCKLL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a596ALAEEQGRLEAIIAAGSSTGGGAEHELEIAADALRLPEWDAKIDNLSGGEKRRVALCKLL       130       140       150       160       170       180       190       200       210       220       230       240 m596.pepLSKPDMLLLDEPTNHLDAESVEWLEQFLVRFPGTVVAVTHDRYFLDNAAEWILELDRGHG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a596LSKPDMLLLDEPTNHLDAESVEWLEQFLVRFPGTVVAVTHDRYFLDNAAEWILELDRGHG       190       200       210       220       230       240       250       260       270       280       290       300 m596.pepIPWKGNYSSWLEQKEKRLENEAKSEAARVKAMKQELEWVRQNAKGRQAKSKARLARFEEM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a596IPWKGNYSSWLEQKEKRLENEAKSEAARVKAMKQELEWVRQNAKGRQAKSKARLARFEEM       250       260       270       280       290       300       310       320       330       340       350       360 m596.pepSNYEYQKRNETQEIFIPVAERLGNEVIEFVNVSKSFGDKVLIDDLSFKVPAGAIVGIIGP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a596SNYEYQKRNETQEIFIPVAERLGNEVIEFVNVSKSFGDKVLIDDLSFKVPAGAIVGIIGP       310       320       330       340       350       360       370       380       390       400       410       420 m596.pepNGAGKSTLFKMISGKEQPDSGEVKIGQTVKMSLIDQSREGLQNDKTVFDNIAEGRDILQV||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| a596NGAGKSTLFKMIAGKEQPDSGEVKIGQTVKMSLIDQSREGLQNDKTVFDNIAEGRDILQV       370       380       390       400       410       420       430       440       450       460       470       480 m596.pepGQFEIPARQYLGRFNFKGSDQSKIAGQLSGGERGRLHLAKTLLSGGNVLLLDEPSNDLDV||||||||||||||||||||||||:||||||||||||||||||:|||||||||||||||| a596GQFEIPARQYLGRFNFKGSDQSKITGQLSGGERGRLHLAKTLLGGGNVLLLDEPSNDLDV       430       440       450       460       470       480       490       500       510       520       530       540 m596.pepETLRALEDALLEFAGSVMVISHDRWFLDRIATHILACEGDSKWVFFDGNYQEYEADKKRR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a596ETLRALEDALLEFAGSVMVISHDRWFLDRIATHILACEGDSKWVFFDGNYQEYEADKKRR       490       500       510       520       530       540       550      559 m596.pep LGEEGAKPKRIKYKPVTRX |||||:|||||||||||||a596 LGEEGTKPKRIKYKPVTRX        550The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1877>

g597.seq 1 ATGCTGCTTC ATGTCAGCAA TTCCCTCAAA CAGCTTCAGG AAGAGCGTAT 51CCGCCAAGAA CGTATCCGCC AAGAGCGTAT CCGTCAGGCG CGCGGCAACC 101 TTGCTTCCGTCAACCGCAAA CAGCGCGAGG CTTGGGACAA ATTCCAAAAA 151 CTCAATACCG AGCTGAACCGTTTGAAAACG GAAGTCGCCG CTACGAAAGC 201 GCAGATTTCC CGTTTCGTAT CGGGGAACTATAAAAACAGC CGGCCGAATG 251 CGGTTGCCCT GTTCCTGAAA AACGCCGAAC CGGGTCAGAAAAACCGCTTT 301 TTGCGTTATA CGCGTTATGT AAACGCCTCC AATCGGGAAG TTGTCAAGGA351 TTTGGAAAAA CAGCAGAAGG CTTTGGCGGT ACAAGAGCAG AAAATCAACA 401ATGAGCTTGC CCGTTTGAAG AAAATTCAGG CAAACGTGCA ATCCCTGCTG 451 AAAAAACAGGGTGTAACCGA TGCGGCGGAA CAGACGGAAA GCCGCAGACA 501 GAATGCCAAA ATCTCCAAAGATGCCCGAAA ACTGCTGGAA CAGAAAGGGA 551 ACGAGCAGCA GCTGAACAAG CTCTTGAGCAATTTGgagaa aaAAAaagcc 601 gaacaccgCA TTcaggAtgc ggAagcaaAA agaAAATTGGCTGAagcCaa 651 actGgcggca gccgAAAAAG CCAGAAAAGA AGCGGCGCAG CAGAAGGCTG701 AAGCGCGACG TGCGGAAATG TCCAACCTGA CCGCCGAAGA CAGGAACATC 751CAAGCGCCTT CGGTTATGGG TATCGGCAGT GCCGACGgTT TCAGCCGCAT 801 GCAGGGACGTTTGAAAAAAC CGGTTGACGG TGTGCCGACC GGGCTTTTCG 851 GGCAGAACCG GAGCGGcggCGATGTTTGGA AAGGCGTGTT CTATTCCACT 901 GCGCCTGCAA CGGTTGAAAG CATTGCGCcggGAACggtaa GCTATGCGGA 951 cgaGTTGGAC GGCTACGGCA AAGTGGTCGT GATCGATCACGGCGAGAACT 1001 ACATCAGCAT CTATGCCGGT TTGAGCGAAA TTTCCGCCGG CAAGGGTTAT1051 ACGGTCGCGG CAGGAAGCAA AATCGGCACG AGCGGGTCGC TGCCGGACGG 1101GGAAGAGGGG CTTTACCTGC AAATACGTTA TCGAGGTCAG GTGTTGAACC 1151 CTTCGGGCTGGATACGTTGAThis corresponds to the amino acid sequence <SEQ ID 1878; ORF 597>:

g597.pep 1 MLLHVSNSLK QLQEERIRQE RIRQERIRQA RGNLASVNRK QREAWDKFQK 51LNTELNRLKT EVAATKAQIS RFVSGNYKNS RPNAVALFLK NAEPGQKNRF 101 LRYTRYVNASNREVVKDLEK QQKALAVQEQ KINNELARLK KIQANVQSLL 151 KKQGVTDAAE QTESRRQNAKISKDARKLLE QKGNEQQLNK LLSNLEKKKA 201 EHRIQDAEAK RKLAEAKLAA AEKARKEAAQQKAEARRAEM SNLTAEDRNI 251 QAPSVMGIGS ADGFSRMQGR LKKPVDGVPT GLFGQNRSGGDVWKGVFYST 301 APATVESIAP GTVSYADELD GYGKVVVIDH GENYISIYAG LSEISAGKGY351 TVAAGSKIGT SGSLPDGEEG LYLQIRYRGQ VLNPSGWIR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1879>:

m597.seq 1 ATGCTGCTTC ATGTCAGCAA TTCCCTCAAA CAGCTTCAGG AAGAGCGTAT 51CCGCCAAGAG CGTATCCGTC AGGCGCGCGG CAACCTTGCT TCCGTCAACC 101 GCAAACAGCGCGAGGCTTGG GACAAGTTCC AAAAACTCAA TACCGAGCTG 151 AACCGTTTGA AAACGGAAGTCGCCGCTACG AAAGCGCAGA TTTCCCGTTT 201 CGTATCGGGG AACTATAAAA ACAGCCAGCCGAATGCGGTT GCCCTGTTCC 251 TGAAAAACGC CGAACCGGGT CAGAAAAACC GCTTTTTGCGTTATACGCGT 301 TATGTAAACG CCTCCAATCG GGAAGTTGTC AAGGATTTGG AAAAACAGCA351 GAAGGCTTTG GCGGTACAAG AGCAGAAAAT CAACAATGAG CTTGCCCGTT 401TGAAGAAAAT TCAGGCAAAC GTGCAATCTC TGCTGAAAAA ACAGGGTGTA 451 ACCGATGCGGCGGAACAGAC GGAAAGCCGC AGACAGAATG CCAAAATCGC 501 CAAAGATGCC CGAAAACTGCTGGAACAGAA AGGGAACGAG CAGCAGCTGA 551 ACAAGCTCTT GAGCAATTTG GAGAAGAAAAAGGCCGAACA CCGCATTCAG 601 GATGCGGAAG CAAAAAGAAA ATTGGCTGAA GCCAGACTGGCGGCAGCCGA 651 AAAAGCCAGA AAAGAAGCGG CGCAGCAGAA GGCTGAAGCA CGACGTGCGG701 AAATGTCCAA CCTGACCGCC GAAGACAGGA ACATCCAAGC GCCTTCGGTT 751ATGGGTATCG GCAGTGCCGA CGGTTTCAGC CGCATGCAAG GACGTTTGAA 801 AAAACCGGTTGACGGTGTGC CGACCGGACT TTTCGGGCAG AACCGGAGCG 851 GCGGCGATAT TTGGAAAGGCGTGTTCTATT CCACTGCACC GGCAACGGTT 901 GAAAGCATTG CGCCGGGAAC GGTAAGCTATGCGGACGAGT TGGACGGCTA 951 CGGCAAAGTG GTCGTGGTCG ATCACGGCGA GAACTACATCAGCATCTATG 1001 CCGGTTTGAG CGAAATTTCC GTCGGCAAGG GTTATATGGT CGCGGCAGGA1051 AGCAAAATCG GCTCGAGCGG GTCGCTGCCG GACGGGGAAG AGGGGCTTTA 1101CCTGCAAATA CGTTATCAAG GTCAGGTATT GAACCCTTCG AGCTGGATAC 1151 GTTGAThis corresponds to the amino acid sequence <SEQ ID 1880; ORF 597>:

m597.pep 1 MLLHVSNSLK QLQEERIRQE RIRQARGNLA SVNRKQREAW DKFQKLNTEL 51NRLKTEVAAT KAQISRFVSG NYKNSQPNAV ALFLKNAEPG QKNRFLRYTR 101 YVNASNREVVKDLEKQQKAL AVQEQKINNE LARLKKIQAN VQSLLKKQGV 151 TDAAEQTESR RQNAKIAKDARKLLEQKGNE QQLNKLLSNL EKKKAEHRIQ 201 DAEAKRKLAE ARLAAAEKAR KEAAQQKAEARRAEMSNLTA EDRNIQAPSV 251 MGIGSADGFS RMQGRLKKPV DGVPTGLFGQ NRSGGDIWKGVFYSTAPATV 301 ESIAPGTVSY ADELDGYGKV VVVDHGENYI SIYAGLSEIS VGKGYMVAAG351 SKIGSSGSLP DGEEGLYLQI RYQGQVLNPS SWIR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 597 shows 96.1% identity over a 389 aa overlap with a predicted ORF(ORF 597) from N. gonorrhoeae:

m597/g597 96.1% identity in 389 aa overlap        10        20        30        40        50        60 g597.pepMLLHVSNSLKQLQEERIRQERIRQERIRQARGNLASVNRKQREAWDKFQKLNTELNRLKT||||||||||||||||||||||||     ||||||||||||||||||||||||||||||| m597MLLHVSNSLKQLQEERIRQERIRQ-----ARGNLASVNRKQREAWDKFQKLNTELNRLKT        10        20             30        40        50        70        80        90       100       110       120 g597.pepEVAATKAQISRFVSGNYKNSRPNAVALFLKNAEPGQKNRFLRYTRYVNASNREVVKDLEK||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||| m597EVAATKAQISRFVSGNYKNSQPNAVALFLKNAEPGQKNRFLRYTRYVNASNREVVKDLEK        60        70        80        90       100       110       130       140       150       160       170       180 g597.pepQQKALAVQEQKINNELARLKKIQANVQSLLKKQGVTDAAEQTESRRQNAKISKDARKLLE|||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||| m597QQKALAVQEQKINNELARLKKIQANVQSLLKKQGVTDAAEQTESRRQNAKIAKDARKLLE  120       130       140       150       160       170       190       200       210       220       230       240 g597.pepQKGNEQQLNKLLSNLEKKKAEHRIQDAEAKRKLAEAKLAAAEKARKEAAQQKAEARRAEM||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||| m597QKGNEQQLNKLLSNLEKKKAEHRIQDAEAKRKLAEARLAAAEKARKEAAQQKAEARRAEM  180       190       200       210       220       230       250       260       270       280       290       300 g597.pepSNLTAEDRNIQAPSVMGIGSADGFSRMQGRLKKPVDGVPTGLFGQNRSGGDVWKGVFYST|||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||| m597SNLTAEDRNIQAPSVMGIGSADGFSRMQGRLKKPVDGVPTGLFGQNRSGGDIWKGVFYST  240       250       260       270       280       290       310       320       330       340       350       360 g597.pepAPATVESIAPGTVSYADELDGYGKVVVIDHGENYISIYAGLSEISAGKGYLVAAGSKIGT|||||||||||||||||||||||||||:|||||||||||||||||:|||| ||||||||: m597APATVESIAPGTVSYADELDGYGKVVVVDHGENYISIYAGLSEISVGKGYMVAAGSKIGS  300       310       320       330       340       350       370       380       390 g597.pep SGSLPDGEEGLYLQIRYRGQVLNPSGWIRX|||||||||||||||||:|||||||:|||| m597 SGSLPDGEEGLYLQIRYQGQVLNPSSWIRX  360       370       380The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1881>

a597.seq 1 ATGCTGCTTC ATGTCAGCAA TTCCCTCAAG CAGCTTCAGG AAGAGCGTAT 51CCGCCAAGAA CGTATCCGCC AAGAGCGTAT CCGTCAGGCG CGCGGCAACC 101 TTGCTTCCGTCAACCGCAAA CAGCGCGAGG CTTGGGACAA GTTCCAAAAA 151 CTCAATACCG AGCTGAACCGTTTGAAAACG GAAGTCGCCG CTACGAAAGC 201 GCAGATTTCC CGTTTCGTAT CGGGGAACTATAAAAACAGC CAGCCGAATG 251 CGGTTGCCCT GTTCCTGAAA AACGCCGAAC CGGGTCAGAAAAACCGCTTT 301 TTGCGTTATA CGCGTTATGT AAACGCCTCC AATCGGGAAG TTGTCAAGGA351 TTTGGAAAAA CAGCAGAAGG CTTTGGCGGT ACAAGAGCAG AAAATCAACA 401ATGAGCTTGC CCGTTTGAAG AAAATTCAGG CAAACGTGCA ATCCCTGCTG 451 AAAAAACAGGGTGTAACCGA TGCGGCGGAA CAGACGGAAA GCCGCAGACA 501 GAATGCCAAA ATCGCCAAAGATGCCCGAAA ACTGCTGGAA CAGAAAGGGA 551 ACGAGCAGCA GCTGAACAAG CTCTTGAGCAATTTGGAGAA GAAAAAGGCC 601 GAACACCGCA TTCAGGATGC GGAAGCAAAA AGAAAATTGGCTGAAGCCAG 651 ACTGGCGGCA GCCGAAAAAG CCAGAAAAGA AGCGGCGCAG CAGAAGGCTG701 AAGCACGACG TGCGGAAATG TCCAACCTGA CCGCCGAAGA CAGGAACATC 751CAAGCGCCTT CGGTTATGGG TATCGGCAGT GCCGACGGTT TCAGCCGCAT 801 GCAAGGACGTTTGAAAAAAC CGGTTGACGG TGTGCCGACC GGACTTTTCG 851 GGCAGAACCG GAGCGGCGGCGATGTTTGGA AAGGCGTGTT CTATTCCACT 901 GCACCGGCAA CGGTTGAAAG CATTGCGCCGGGAACGGTAA GCTATGCGGA 951 CGAGTTGGAC GGCTACGGCA AAGTGGTCGT GGTCGATCACGGCGAGAACT 1001 ACATCAGCAT CTATGCCGGT TTGAGCGAAA TTTCCGTCGG CAAGGGTTAT1051 ATGGTCGCGG CAGGAAGCAA AATCGGCTCG AGCGGGTCGC TGCCGGACGG 1101GGAAGAGGGG CTTTACCTGC AAATACGTTA TCAAGGTCAG GTATTGAACC 1151 CTTCGAGCTGGATACGTTGAThis corresponds to the amino acid sequence <SEQ ID 1882; ORF 597.a>:

a597.pep 1 MLLHVSNSLK QLQEERIRQE RIRQERIRQA RGNLASVNRK QREAWDKFQK 51LNTELNRLKT EVAATKAQIS RFVSGNYKNS QPNAVALFLK NAEPGQKNRF 101 LRYTRYVNASNREVVKDLEK QQKALAVQEQ KINNELARLK KIQANVQSLL 151 KKQGVTDAAE QTESRRQNAKIAKDARKLLE QKGNEQQLNK LLSNLEKKKA 201 EHRIQDAEAK RKLAEARLAA AEKARKEAAQQKAEARRAEM SNLTAEDRNI 251 QAPSVMGIGS ADGFSRMQGR LKKPVDGVPT GLFGQNRSGGDVWKGVFYST 301 APATVESIAP GTVSYADELD GYGKVVVVDH GENYISIYAG LSEISVGKGY351 MVAAGSKIGS SGSLPDGEEG LYLQIRYQGQ VLNPSSWIR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 597 shows 98.5% identity over a 389 aa overlap with a predicted ORF(ORF 597) from N. meningitidis

m597/a597 98.5% identity in 389 aa overlap        10        20        30        40        50        60 a597.pepMLLHVSNSLKQLQEERIRQERIRQERIRQARGNLASVNRKQREAWDKFQKLNTELNRLKT||||||||||||||||||||||||     ||||||||||||||||||||||||||||||| m597MLLHVSNSLKQLQEERIRQERIRQ-----ARGNLASVNRKQREAWDKFQKLNTELNRLKT        10             20        30        40        50        70        80        90       100       110       120 a597.pepEVAATKAQISRFVSGNYKNSQPNAVALFLKNAEPGQKNRFLRYTRYVNASNREVVKDLEK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m597EVAATKAQISRFVSGNYKNSQPNAVALFLKNAEPGQKNRFLRYTRYVNASNREVVKDLEK   60        70        80        90       100       110       130       140       150       160       170       180 a597.pepQQKALAVQEQKINNELARLKKIQANVQSLLKKQGVTDAAEQTESRRQNAKIAKDARKLLE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m597QQKALAVQEQKINNELARLKKIQANVQSLLKKQGVTDAAEQTESRRQNAKIAKDARKLLE  120       130       140       150       160       170       190       200       210       220       230       240 a597.pepQKGNEQQLNKLLSNLEKKKAEHRIQDAEAKRKLAEARLAAAEKARKEAAQQKAEARRAEM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m597QKGNEQQLNKLLSNLEKKKAEHRIQDAEAKRKLAEARLAAAEKARKEAAQQKAEARRAEM  180       190       200       210       220       230       250       260       270       280       290       300 a597.pepSNLTAEDRNIQAPSVMGIGSADGFSRMQGRLKKPVDGVPTGLFGQNRSGGDVWKGVFYST|||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||| m597SNLTAEDRNIQAPSVMGIGSADGFSRMQGRLKKPVDGVPTGLFGQNRSGGDIWKGVFYST  240       250       260       270       280       290       310       320       330       340       350       360 a597.pepAPATVESIAPGTVSYADELDGYGKVVVVDHGENYISIYAGLSEISVGKGYMVAAGSKIGS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m597APATVESIAPGTVSYADELDGYGKVVVVDHGENYISIYAGLSEISVGKGYMVAAGSKIGS  300       310       320       330       340       350       370       380       390 a597.pep SGSLPDGEEGLYLQIRYQGQVLNPSSWIRX|||||||||||||||||||||||||||||| m597 SGSLPDGEEGLYLQIRYQGQVLNPSSWIRX  360       370       380The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1883>:

g601.seq 1 ATGTTCCCAA CCGGCAATTT GGTCGACGAA ATTGATGTGC CGAATATAGG 51TCGTCTGAAA GCCACGCTCA TCAACGCGGG CATTCCGACC GTTTTCCTGA 101 ACGCCGCCGACTTGGGCTAC ACGGGCAAAG AGTTGCAGGA CGACATCAAC 151 AACGATGCCG CCGCGCTGGAAAAATTTGAA ACCATCCGCG CATATGGCGC 201 GCTGAAAATG GGTTTGATCA GCGACGTATCCGAAGCCGCC GCCCGCGCGC 251 GCACGCCGAA ACCCGCCTTC GTCGCGCCCG CCGCCGATTACACCGCCTCC 301 AGCGGCAAAA CCGTAAACGC CGCCGACATC GATTTGCCGG TACGCGCCCT351 GAGCATGGGC AAACTGCACC ACGCTATGAT GGGCATCGCC TCGGTCGCCA 401TCGCCGCCGC CGTGCTCGGT ACGCTGGTCA ACCTTGCCGC AGGCGGCGGA 451 ACGCGTAAAGAAGTGCGCTT CGGGCATCCG TCAGGTACGC TGCGTGTCGG 501 TGCTGCCGCC GAATGTCAGGACGGACAATG GACGGCCGCc aaagcggtca 551 tgaGCCGCAG CGCACgcgtg attatggaaagttgGGTGCg cgttcccgat 601 gattGTTTTT GAThis corresponds to the amino acid sequence <SEQ ID 1884; ORF 601.ng>:

g601.pep 1 MFPTGNLVDE IDVPNIGRLK ATLINAGIPT VFLNAADLGY TGKELQDDIN 51NDAAALEKFE TIRAYGALKM GLISDVSEAA ARARTPKPAF VAPAADYTAS 101 SGKTVNAADIDLPVRALSMG KLHHAMMGIA SVAIAAAVLG TLVNLAAGGG 151 TRKEVRFGHP SGTLRVGAAAECQDGQWTAA KAVMSRSARV IMESWVRVPD 201 DCF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1885>:

m601.seq 1 ATGTTCCCAA CCGGCAATTT GGTCGATGAA ATTGATGTGC CGAATATAGG 51CCGTTTGAAA GCCACGCTCA TCAACGCGGG CATTCCGACC GTTTTCTTGA 101 ATGCCGCCGACTTGGGCTAC ACAGGCAAAG AGTTGCAAGA CGACATCAAC 151 AACGATGCCG CGGCTTTGGAAAAATTCGAG AAAATCCGCG CTTACGGTGC 201 GCTGAAAATG GGTCTGATCA GCGACGTATCCGAAGCTGCC GCTCGCGCGC 251 ACACGCCGAA AGTCGCCTTC GTCGCGCCCG CCGCCGATTACACCGCCTCC 301 AGTGGCAAAA CCGTGAACGC CGCCGACATC GATTTGCTGG TACGCGCCCT351 GAGCATGGGC AAACTGCACC ACGCGATGAT GGGTACCGCC TCTGTTGCCA 401TTGCGACCGC CGCCGCCGTA CCCGGTACGC TGGTCAACCT TGCCGCAGGC 451 GGCGGAACGCGTAAAGAAGT GCGCTTCGGG CATCCTTCCG GCACATTGCG 501 CGTCGGTGCA GCCGCCGAATGTCAGGACGG ACAATGGACG GCCACCAAAG 551 CGGTCATGAG CCGTAGCGCA CGCGTGATGATGGAAGGTTG GGTCAGGGTG 601 CCTGAGGATT GTTTTTAAThis corresponds to the amino acid sequence <SEQ ID 1886; ORF 601>:

m601.pep 1 MFPTGNLVDE IDVPNIGRLK ATLINAGIPT VFLNAADLGY TGKELQDDIN 51NDAAALEKFE KIRAYGALKM GLISDVSEAA ARAHTPKVAF VAPAADYTAS 101 SGKTVNAADIDLLVRALSMG KLHHAMMGTA SVAIATAAAV PGTLVNLAAG 151 GGTRKEVRFG HPSGTLRVGAAAECQDGQWT ATKAVMSRSA RVMMEGWVRV 201 PEDCF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 601 shows 94.1% identity over a 205 aa overlap with a predicted ORF(ORF 601.ng) from N. gonorrhoeae:

m601/g601          10        20        30        40        50        60m601.pep  MFPTGNLVDEIDVPNIGRLKATLINAGIPTVFLNAADLGYTGKELQDDINNDAAALEKFE |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g601 MFPTGNLVDEIDVPNIGRLKATLINAGIPTVFLNAADLGYTGKELQDDINNDAAALEKFE         10        20        30        40        50        60         70        80        90       100       110       120 m601.pep KIRAYGALKMGLISDVSEAAARAHTPKVAFVAPAADYTASSGKTVNAADIDLLVRALSMG  ||||||||||||||||||||||:||| |||||||||||||||||||||||| ||||||| g601 TIRAYGALKMGLISDVSEAAARARTPKPAFVAPAADYTASSGKTVNAADIDLPVRALSMG         70        80        90       100       110       120        130       140       150       160       170       180 m601.pep KLHHAMMGTASVAIATAAAVPGTLVNLAAGGGTRKEVRFGHPSGTLRVGAAAECQDGQWT |||||||| |||||  |||| ||||||||||||||||||||||||||||||||||||||| g601 KLHHAMMGIASVAI--AAAVLGTLVNLAAGGGTRKEVRFGHPSGTLRVGAAAECQDGQWT        130         140       150       160       170        190       200 m601.pep  ATKAVMSRSARVMMEGWVRVPEDCFX |:||||||||||:||:|||||:|||| g601  AAKAVMSRSARVIMESWVRVPDDCFX180       190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1887>:

a601.seq 1 ATGTTCCCAA CCGGCAATTT GGTCGATGAA ATTGATGTGC CGAATATAGG 51CCGTTTGAAA GCCACGCTCA TCAACGCGGG CATTCCGACC GTTTTCCTGA 101 ATGCCGCCGACTTGGGCTAC ACGGGCAAAG AGTTGCAAGA CGACATCAAC 151 AACGATGCCG CAGCTTTGGAAAAATTCGAG AAAATCCGCG CTTACGGTGC 201 GCTGAAAATG GGTCTGATCA GCGACGTATCCGAAGCTGCC GCCCGCGCGC 251 ACACGCCGAA AGTCGCCTTC GTCGCGCCCG CCGCCGATTACACCGCCTCC 301 AGTGGCAAAA CCGTGAATGC CGCCGACATC GATTTGCTGG TACGCGCCCT351 GAGCATGGGC AAATTGCACC ACGCGATGAT GGGTACCGCC TCTGTTGCCA 401TTGCGACCGC CGCCGCCGTG CCCGGTACGC TGGTCAACCT TGCCGCAGGC 451 GGCGGAACGCGTAAAGAAGT GCGCTTCGGG CATCCTTCCG GCACATTGCG 501 CGTCGGTGCA GCCGCCGAATGTCAGGACGG ACAATGGACG GCCACCAAAG 551 CGGTTATGAG CCGCAGCGCA CGCGTGATGATGGAAGGTTG GGTCAGGGTG 601 CCGGAAGATT GTTTTTAAThis corresponds to the amino acid sequence <SEQ ID 1888; ORF 601.a>:

a601.pep 1 MFPTGNLVDE IDVPNIGRLK ATLINAGIPT VFLNAADLGY TGKELQDDIN 51NDAAALEKFE KIRAYGALKM GLISDVSEAA ARAHTPKVAF VAPAADYTAS 101 SGKTVNAADIDLLVRALSMG KLHHAMMGTA SVAIATAAAV PGTLVNLAAG 151 GGTRKEVRFG HPSGTLRVGAAAECQDGQWT ATKAVMSRSA RVMMEGWVRV 201 PEDCF* m601/a601 100.0% identity in205 aa overlap        10        20        30        40        50        60 m601.pepMFPTGNLVDEIDVPNIGRLKATLINAGIPTVFLNAADLGYTGKELQDDINNDAAALEKFE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a601MFPTGNLVDEIDVPNIGRLKATLINAGIPTVFLNAADLGYTGKELQDDINNDAAALEKFE        10        20        30        40        50        60        70        80        90       100       110       120 m601.pepKIRAYGALKMGLISDVSEAAARAHTPKVAFVAPAADYTASSGKTVNAADIDLLVRALSMG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a601KIRAYGALKMGLISDVSEAAARAHTPKVAFVAPAADYTASSGKTVNAADIDLLVRALSMG        70        80        90       100       110       120       130       140       150       160       170       180 m601.pepKLHHAMMGTASVAIATAAAVPGTLVNLAAGGGTRKEVRFGHPSGTLRVGAAAECQDGQWT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a601KLHHAMMGTASVAIATAAAVPGTLVNLAAGGGTRKEVRFGHPSGTLRVGAAAECQDGQWT       130       140       150       160       170       180       190       200 m601.pep ATKAVMSRSARVMMEGWVRVPEDCFX|||||||||||||||||||||||||| a601 ATKAVMSRSARVMMEGWVRVPEDCFX       190       200The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1889>:

g602.seq 1 ATGTTGCTCC ATCAATGCGA CAAAGCGCGA CATATGCGTC CCTTTCTGCT 51CGGCGGGCAG ATAAACCGTC ATCGTCAGGC GAGCAACCGT GGATTGTGTT 101 CCTTCGGCGGTTTTCAGGGT AATCGGGAAG CGCAGGTCTT TAATGCCGAC 151 CTGATTGATC GGCAGGTTGCGCAAATCTCT GCTGGATTGC ACGTCTGCAA 201 TGGCGTTCAT GCGTTGTTTG TCCTTAATATTCAGATAATT ATTGAGATGT 251 GTGTATTGTA TGGCAGGcag atgccgtctg aAAAAacgctgtcggCCGCC 301 TGCCTGCAAA TgcgagattA TATCACTTGC TTTtggcgGC TGCATTGAThis corresponds to the amino acid sequence <SEQ ID 1890; ORF 602.ng>:

g602.pep 1 MLLHQCDKAR HMRPFLLGGQ INRHRQASNR GLCSFGGFQG NREAQVFNAD 51LIDRQVAQIS AGLHVCNGVH ALFVLNIQII IEMCVLYGRQ MPSEKTLSAA 101 CLQMRDYITCFWRLH*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1891>:

m602.seq 1 ATGTTGCTCC ATCAATGCGA CAAAACGCGA CATATGCGTC CCCTTCTGCT 51CAGCAGGCAG GTAAACCGTC ATGGTCAGAC GGGCAATGGT GGACTGGATG 101 CCTTCTGCAGTTTGCAGGGT AATCGGAAAG CGCAGGTCTT TGATACCGAC 151 CTGATTGATC GGCAGATTGCGCAAATCTCG GCTGGATTGC ACGTCTGCAA 201 TAGTGTTCAT GAGTTGTTTT TCCTTAATATTCATGTAATT GTTGAGATGT 251 GTGCATGGTA TGGCGTTTCC GCCGGGGAAT ATACCGTCAATCTGCAAATG 301 CGAGATTATA TCACTCGCTT TTAGCAGCTG CATTGAThis corresponds to the amino acid sequence <SEQ ID 1892; ORF 602>:

m602.pep 1 MLLHQCDKTR HMRPLLLSRQ VNRHGQTGNG GLDAFCSLQG NRKAQVFDTD 51LIDRQIAQIS AGLHVCNSVH ELFFLNIHVI VEMCAWYGVS AGEYTVNLQM 101 RDYITRF*QL H*m602/g602 65.2% identity in 115 aa overlap        10        20        30        40        50        60 m602.pepMLLHQCDKTRHMRPLLLSRQVNRHGQTGNGGLDAFCSLQGNRKAQVFDTDLIDRQIAQIS||||||||:|||||:||: |:||| |::| || :| ::||||:||||::||||||:|||| g602MLLHQCDKARHMRPFLLGGQINRHRQASNRGLCSFGGFQGNREAQVFNADLIDRQVAQIS        10        20        30        40        50        60        70        80        90           100       110 m602.pepAGLHVCNSVHELFFLNIHVIVEMCAWYGVSA-GEYTVN---LQMRDYITRFXQLHX|||||||:|| || |||::|:|||: || :  :| |::   |||||||| | :||| g602AGLHVCNGVHALFVLNIQIIIEMCVLYGRQMPSEKTLSAACLQMRDYITCFWRLHX        70        80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1893>:

a602.seq 1 ATGTTGCTCC ATCAATGCGA CAAAGCGCGA CATATGCGTA CCCTTCTGCT 51CGGCAGGCAG GTAAACCGTC ATGGTCAGAC GGGCAACTGT GGACTGGATG 101 CCTTCTGCAGTTTGCAGGGT AATCGGAAAG CGCAGGTCTT TGATACCGAC 151 CTGATTGATC GGCAGATTGCGCAAATCTCG GCTGGATTGC ACGTCTGCAA 201 TAGTGTTCAT GAGTTGTTTT TCCTTAATATTCATGTAATT GTTGAGATGT 251 GTGCATGGTA TGGCGTTTCC ACCGGGGAAT ATACCGTCAATCTGCAAATG 301 CGAGATTATA TCACTCGCTT TTAGCAGCTG CATTGAThis corresponds to the amino acid sequence <SEQ ID 1894; ORF 602.a>:

a602.pep 1 MLLHQCDKAR HMRTLLLGRQ VNRHGQTGNC GLDAFCSLQG NRKAQVFDTD 51LIDRQIAQIS AGLHVCNSVH ELFFLNIHVI VEMCAWYGVS TGEYTVNLQM 101 RDYITRF*QL H*m602/a602 95.5% identity in 111 aa overlap        10        20        30        40        50        60 m602.pepMLLHQCDKTRHMRPLLLSRQVNRHGQTGNGGLDAFCSLQGNRKAQVFDTDLIDRQIAQIS||||||||:|||| |||:||||||||||| |||||||||||||||||||||||||||||| a602MLLHQCDKARHMRTLLLGRQVNRHGQTGNCGLDAFCSLQGNRKAQVFDTDLIDRQIAQIS        10        20        30        40        50        60        70        80        90       100       110 m602.pepAGLHVCNSVHELFFLNIHVIVEMCAWYGVSAGEYTVNLQMRDYITRFXQLHX||||||||||||||||||||||||||||||:||||||||||||||||||||| a602AGLHVCNSVHELFFLNIHVIVEMCAWYGVSTGEYTVNLQMRDYITRFXQLHX        70        80        90       100       110The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 1895>:

g603.seq 1 ATGGATTCCC GCCTGCGTGG GAATGACGCT AGGAAATACG GCATACGCTT 51TGCCCAAAGA GGCCGTCTGA AACACACTCC GCCCAACGCC CATCCTTTTT 101 CAGACGGCCCCGCACCAAAA AAACAACCAC AAACTACAAG GAGAAACATC 151 ATGTCCGACC AACTCATTCTTGTCCTGAAC TGCGTCAGTT CATCGCTCAA 201 AGGCGCCGTT ATCGACCGCA AAAGCGGCAGCGTCGTCCTA AGCTGCCTCG 251 GGGAACGCCT GACTACGCCC GAAGCCGTCA TTACCTTCAACAAAGACGGC 301 AACAAACGCC AAGTTCCCCT GAGCGGCCGC AACTGCCACG CCGGCGCGGT351 GGGTATGCTG TTGAACGAAC TGGAAAAACA CGGACTGCAC GACCGCATCA 401AAGCCATCGG CCGCCGCATC GCCCACGGCG GCGAAAAATA TCACGAGTCC 451 GTCCTCATCGACCAAGACGT CCTTGACGAA CTGAAAGCCT GCATCCCGTT 501 CGCCCCGCTG CACAACCCCGCCAACATCAG CGGCATCCTC GCCGCGCAGG 551 AACACTTTCC CGGCCTGCCC AACGTCGGCGTGATGGACAC CTCGTTCCAC 601 CAAACCATGC CGGAGCGGGC CTACACTTAT GCCGTGCCGCGCGAATTGCG 651 CAAAAAATAC GCCTTCCGCC GCTACGGTTT CCACGGTACC GGTATGCGTT701 ACGTCGCCCC TGAAGCCGCA CGCATCTTGG GCAAACCTct ggaaGACATC 751CGCATGATTA TTGCCCACTT AGGCAACGGC GCATCTATTA CCGCCGTCAA 801 AAACGGCAAATCCGTCGATA CCGGTATGGG TTTCACGCCG ATCGAAGGTT 851 TGGTAATGGG TACACGTTGCGGCGACACCG ATCCGGGCGT ATACAGCTAT 901 CCGACTTTCC ACGCAGGGAT GGATGTTGCCCAAGTTGATG AAATGCTGAA 951 CGAAAAATCA GGTTTCCCCG GTATTTCcgA actTCCCAACGACTGCCGCA 1001 CCCTCGAAAT CGCCGCCGAC GAAGGCCGCG AAGGCGCGCG CCTCGCCCTc1051 gaAGTCATGA CCTGCCGCCT CGCCAAATAC ATCGCTTCGA TGGCTGTGGC 1101CTGCGGCAGT GTTGACGCAC TCGTGTTCAC CGGCGGTATC GGCGAAAACT 1151 CGCGTAATATCCGTGCCAAA ACCGTTTCCT ATCTTGATTT CTTGGGTCTG 1201 CACATCGACA CCAAAGCCAATATGGAAAAA CGCTACGGCA ATTCGGGCAT 1251 TATCAGCCCG ACCGATTCTT CTCCGGCTGTTTTGGTCGTC CCGACCAATG 1301 AAGAACTGAT GATTGCCTGC GACACTGCCG AACTTGCCGGCATCTTGTAGThis corresponds to the amino acid sequence <SEQ ID 1896; ORF 603.ng>:

g603.pep 1 MDSRLRGNDA RKYGIRFAQR GRLKHTPPNA HPFSDGPAPK KQPQTTRRNI 51MSDQLILVLN CVSSSLKGAV IDRKSGSVVL SCLGERLTTP EAVITFNKDG 101 NKRQVPLSGRNCHAGAVGML LNELEKHGLH DRIKAIGRRI AHGGEKYHES 151 VLIDQDVLDE LKACIPFAPLHNPANISGIL AAQEHFPGLP NVGVMDTSFH 201 QTMPERAYTY AVPRELRKKY AFRRYGFHGTGMRYVAPEAA RILGKPLEDI 251 RMIIAHLGNG ASITAVKNGK SVDTGMGFTP IEGLVMGTRCGDTDPGVYSY 301 PTFHAGMDVA QVDEMLNEKS GFPGISELPN DCRTLEIAAD EGREGARLAL351 EVMTCRLAKY IASMAVACGS VDALVFTGGI GENSRNIRAK TVSYLDFLGL 401HIDTKANMEK RYGNSGIISP TDSSPAVLVV PTNEELMIAC DTAELAGIL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1897>:

m603.seq 1 CTGTCCTCGC GTAGGCGGGG ACGGAATAAC GATAGAAAAT GCGGCATACG 51CTTTGCCCAA AGAGGCCGTC TGAAACACCT TGCGCCTGAT GTCTGC.CTT 101TTTCAGACGA CCCCACACTA AAAAAACAAC CACAAACTAC AAGGAGAAAC 151ATCATGTCCG ACCAACTCAT CCTCGTTCTG AACTGCGGCA GTTCATCGCT 201CAAAGGCGCC GTTATCGACC GAmAAAGCGG CAGCGTCGTC CTAAGCTGCC 251TCGGCGAACG cCtGACCACG CCCGAAGCCG TCATTACGTT CAACAAAGAC 301GGCAACAAAC GCCAAGTTCC CCTGAGCGGC CGAAATTGCC ACGCCGGCGC 351GGTGGGTATG CTTTTGAACG AACTGGAAAA ACACGGTCTG CACGACCGCA 401TCAAAGCCAT CGGCCACCGC ATCGCCCACG GCGGCGAAAA ATACAGCGAG 451TCTGTTTTGA TCGACCAGGC CGTAATGGAC GAACTCAATG CCTGCATTCC 501GCTTGCGCCG CTGCACAACC CCGCCAACAT CAGCGGCATC CTTGCCGCAC 551AGGAACATTT CCCCGGTCTG CCCAATGTCG GCGTGATGGA TACTTCGTTC 601CACCAAACCA TGCCGGAGCG TGCCTACACT TATGCCGTGC CGCGCGAGTT 651GCGTAAAAAA TACGCTTTCC GCCGCTACGG TTTCCACGGC ACCAGTATGC 701GTTACGTTGC CCCTGAAGCC GCACGCATCT TGGGCAAACC TCTGGAAGAC 751ATCCGCATGA TTATTGCCCA CTTAGGCAAC GGCGCATCCA TTACCGCCAT 801CAAAAACGGC AAATCCGTCG ATACCAGTAT GGGTTTCACG CCGATCGAAG 851GTTTGGTAAT GGGTACACGT TGCGGCGACA TCGATCCGGG CGTATACAGC 901TATCTGACTT CCCACGCCGG GATGGATGTT GCCCAAGTGG ATGAAATGCT 951GAACAAAAAA TCAGGTTTGC TCGGTATTTC CGAACTTTCC AACGACTGCC 1001GCACCCTCGA AATCGCCGCC GACGAAGGCC ACGAAGGCGC GCGCCTCGCC 1051CTCGAAGTCA TGACCTACCG CCTCGCCAAA TACATCGCTT CGATGGCTGT 1101GGGCTGCGGC GGCGTTGACG CACTCGTGTT CACCGGCGGT ATCGGCGAAA 1151ACTCGCGTAA TATCCGTGCC AAAACCGTTT CCTATCTTGA TTTCTTGGGT 1201CTGCACATCG ACACCAAAGC CAATATGGAA AAACGCTACG GCAATTCGGG 1251CATTATCAGC CCGACCGATT CTTCTCCGGC TGTTTTGGTT GTCCCGACCA 1301ATGAAGAACT GATGATTGCC TGCGACACTG CCGAACTTGC CGGCATCTTG 1351 TAGThis corresponds to the amino acid sequence <SEQ ID 1898; ORF 603>:

m603.pep 1 LSSRRRGRNN DRKCGIRFAQ RGRLKHLAPD VCXFSDDPTL KKQPQTTRRN 51IMSDQLILVL NCGSSSLKGA VIDRXSGSVV LSCLGERLTT PEAVITFNKD 101GNKRQVPLSG RNCHAGAVGM LLNELEKHGL HDRIKAIGHR IAHGGEKYSE 151SVLIDQAVMD ELNACIPLAP LHNPANISGI LAAQEHFPGL PNVGVMDTSF 201HQTMPERAYT YAVPRELRKK YAFRRYGFHG TSMRYVAPEA ARILGKPLED 251IRMIIAHLGN GASITAIKNG KSVDTSMGFT PIEGLVMGTR CGDIDPGVYS 301YLTSHAGMDV AQVDEMLNKK SGLLGISELS NDCRTLEIAA DEGHEGARLA 351LEVMTYRLAK YIASMAVGCG GVDALVFTGG IGENSRNIRA KTVSYLDFLG 401LHIDTKANME KRYGNSGIIS PTDSSPAVLV VPTNEELMIA CDTAELAGIL 451 *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 603 shows 91.6% identity over a 450 aa overlap with a predicted ORF(ORF 603.ng) from N. gonorrhoeae:

m603/g603           10        20        30        40        50        60m603.pep   LSSRRRGRNNDRKCGIRFAQRGRLKHLAPDVCXFSDDPTLKKQPQTTRRNIMSDQLILVL  ::|| || |: || ||||||||||||  |::  ||| |: |||||||||||||||||||| g603  MDSRLRG-NDARKYGIRFAQRGRLKHTPPNAHPFSDGPAPKKQPQTTRRNIMSDQLILVL           10        20        30        40        50          70        80        90       100       110       120 m603.pep  NCGSSSLKGAVIDRXSGSVVLSCLGERLTTPEAVITFNKDGNKRQVPLSGRNCHAGAVGM   ||||||||||||| ||||||||||||||||||||||||||||||||||||||||||||| g603  NCVSSSLKGAVIDRKSGSVVLSCLGERLTTPEAVITFNKDGNKRQVPLSGRNCHAGAVGM 60        70        80        90       100       110         130       140       150       160       170       180 m603.pep  LLNELEKHGLHDRIKAIGHRIAHGGEKYSESVLIDQAVMDELNACIPLAPLHNPANISGI  ||||||||||||||||||:||||||||| ||||||| |:|||:||||:|||||||||||| g603  LLNELEKHGLHDRIKAIGRRIAHGGEKYHESVLIDQDVLDELKACIPFAPLHNPANISGI120       130       140       150       160       170         190       200       210       220       230       240 m603.pep  LAAQEHFPGLPNVGVMDTSFHQTMPERAYTYAVPRELRKKYAFRRYGFHGTSMRYVAPEA  |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||| g603  LAAQEHFPGLPNVGVMDTSFHQTMPERAYTYAVPRELRKKYAFRRYGFHGTGMRYVAPEA180       190       200       210       220       230         250       260       270       280       290       300 m603.pep  ARILGKPLEDIRMIIAHLGNGASITAIKNGKSVDTSMGFTPIEGLVMGTRCGDIDPGVYS  ||||||||||||||||||||||||||:||||||||:||||||||||||||||| |||||| g603  ARILGKPLEDIRMIIAHLGNGASITAVKNGKSVDTGMGFTPIEGLVMGTRCGDTDPGVYS240       250       260       270       280       290         310       320       330       340       350       360 m603.pep  YLTSHAGMDVAQVDEMLNKKSGLLGISELSNDCRTLEIAADEGHEGARLALEVMTYRLAK   | |||||||||||||||:|||: ||||| |||||||||||||:||||||||||| |||| g603  YPTFHAGMDVAQVDEMLNEKSGFPGISELPNDCRTLEIAADEGREGARLALEVMTCRLAK300       310       320       330       340       350         370       380       390       400       410       420 m603.pep  YIASMAVGCGGVDALVFTGGIGENSRNIRAKTVSYLDFLGLHIDTKANMEKRYGNSGIIS  |||||||:||:||||||||||||||||||||||||||||||||||||||||||||||||| g603  YIASMAVACGSVDALVFIGGIGENSRNIRAKTVSYLDFLGLHIDTKANMEKRYGNSGIIS360       370       380       390       400       410         430       440       450 m603.pep  PTDSSPAVLVVPTNEELMIACDTAELAGILX   ||||||||||||||||||||||||||||||| g603  PTDSSPAVLVVPTNEELMIACDTAELAGILX 420       430       440       450The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1899>:

a603.seq 1 CTGTCCTCGC GTAGGCGGGG ACGGAATAAC GATAGAAAAT GCGGCATACG 51CTTTGCCCAA AGAGGCCGTC TGAAACACAC TCCGCCCAAC GCCCATCCTT 101TTTCAGACGA CCCCACACC. AAAAAACAAC CACAAACTAC AAGGAGAAAC 151ATCATGTCCG ACCAACTCAT TCTTGTTCTG AACTGCGGCA GTTCATCGCT 201CAAAGGTGCC GTTATCGACC GCAAAAGCGG CAGCGTCGTC CTAAGCTGCC 251TCGGCGAACG CCTGACCACG CCCGAAGCCG TCATTACGTT CAGCAAAGAC 301GGCAACAAAC GCCAAGTTCC CCTGAGCGGC CGGAACTGCC ACGCCGGCGC 351GGTGGGTATG CTGTTGAACG AACTGGAAAA ACACGAACTG CACGACCGCA 401TTCAAGCCGT CGGCCACCGC ATCGCCCACG GCGGCGAAAA ATACAGCGAG 451TCTGTTTTGA TCGACCAGGC CGTAATGGAC GAACTCAATG CCTGCATTCC 501GCTTGCGCCG CTGCACAACC CCGCCAACAT CAGCGGCATC CTCGCCGCAC 551AGGAACATTT CCCCGGTCTG CCCAATGTCG GCGTGATGGA TACTTCGTTC 601CACCAAACCA TGCCGGAGCG TGCCTACACT TATGCCGTGC CGCGCGAGTT 651GCGTAAAAAA TACGCTTTCC GCCGCTACGG TTTCCACGGC ACCAGTATGC 701GTTACGTTGC CCCTGAAGCC GCATGCATCT TGGGCAAACC TCTGGAAGAC 751ATCCGCATGA TTATTGCCCA CTTAGGCAAC GGCGCATCCA TTACCGCCAT 801CAAAAACGGC AAATCCGTCG ATACCAGTAT GGGTTTCACG CCGATCGAAG 851GTTTGGTAAT GGGTACGCGC TGCGGCGATA TCGACCCGGG CGTATACAGC 901TATCTGACTT CACACGCCGG TTTGGATGTT GCACAAGTTG ATGAAATGCT 951GAATAAAAAA TCAGGCTTGC TCGGTATTTC CGAACTCTCC AACGACTGCC 1001GCACCCTCGA AATCGCCGCC GACGAAGGCC ACGAAGGCGC GCGCCTCGCC 1051CTCGAAGTTA TGACCTACCG CCTCGCCAAA TACATCGCTT CGATGGCTGT 1101GGGCTGCGGC GGCGTTGACG CACTCGTGTT CACCGGCGGT ATCGGCGAAA 1151ACTCGCGTAA TATCCGTGCC AAAACCGTTT CCTATCTTGA TTTCTTGGGT 1201CTGCACATCG ACACCAAAGC CAATATGGAA AAACGCTACG GCAATTCGGG 1251TATTATCAGC CCGACCGATT CTTCTCCGGC TGTTTTGGTT GTCCCGACCA 1301ATGAAGAACT GATGATTGCC TGCGACACTG CCGAACTTGT CGGCATCTTG 1351 TAGThis corresponds to the amino acid sequence <SEQ ID 1900; ORF 603.a>:

a603.pep 1 LSSRRRGRNN DRKCGIRFAQ RGRLKHTPPN AHPFSDDPTX KKQPQTTRRN 51IMSDQLILVL NCGSSSLKGA VIDRKSGSVV LSCLGERLTT PEAVITFSKD 101GNKRQVPLSG RNCHAGAVGM LLNELEKHEL HDRIQAVGHR IAHGGEKYSE 151SVLIDQAVMD ELNACIPLAP LHNPANISGI LAAQEHFPGL PNVGVMDTSF 201HQTMPERAYT YAVPRELRKK YAFRRYGFHG TSMRYVAPEA ACILGKPLED 251IRMIIAHLGN GASITAIKNG KSVDTSMGFT PIEGLVMGTR CGDIDPGVYS 301YLTSHAGLDV AQVDEMLNKK SGLLGISELS NDCRTLEIAA DEGHEGARLA 351LEVMTYRLAK YIASMAVGCG GVDALVFTGG IGENSRNIRA KTVSYLDFLG 401LHIDTKANME KRYGNSGIIS PTDSSPAVLV VPTNEELMIA CDTAELVGIL 451 * m603/a60396.7% identity in 450 aa overlap        10        20        30        40        50        60 m603.pepLSSRRRGRNNDRKCGIRFAQRGRLKHLAPDVCXFSDDPTLKKQPQTTRRNIMSDQLILVL||||||||||||||||||||||||||  |::  |||||| |||||||||||||||||||| a603LSSRRRGRNNDRKCGIRFAQRGRLKHTPPNAHPFSDDPTXKKQPQTTRRNIMSDQLILVL        10        20        30        40        50        60        70        80        90       100       110       120 m603.pepNCGSSSLKGAVIDRXSGSVVLSCLGERLTTPEAVITFNKDGNKRQVPLSGRNCHAGAVGM|||||||||||||| ||||||||||||||||||||||:|||||||||||||||||||||| a603NCGSSSLKGAVIDRKSGSVVLSCLGERLTTPEAVITFSKDGNKRQVPLSGRNCHAGAVGM        70        80        90       100       110       120       130       140       150       160       170       180 m603.pepLLNELEKHGLHDRIKAIGHRIAHGGEKYSESVLIDQAVMDELNACIPLAPLHNPANISGI |||||||||||||:|:||||||||||||||||||||||||||||||||||||||||||| a603LLNELEKHELHDRIQAVGHRIAHGGEKYSESVLIDQAVMDELNACIPLAPLHNPANISGI       130       140       150       160       170       180       190       200       210       220       230       240 m603.pepLAAQEHFPGLPNVGVMDTSFHQTMPERAYTYAVPRELRKKYAFRRYGFHGTSMRYVAPEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a603LAAQEHFPGLPNVGVMDTSFHQTMPERAYTYAVPRELRKKYAFRRYGFHGTSMRYVAPEA       190       200       210       220       230       240       250       260       270       280       290       300 m603.pepARILGKPLEDIRMIIAHLGNGASITAIKNGKSVDTSMGFTPIEGLVMGTRCGDIDPGVYS ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a603ACILGKPLEDIRMIIAHLGNGASITAIKNGKSVDTSMGFTPIEGLVMGTRCGDIDPGVYS       250       260       270       280       290       300       310       320       330       340       350       360 m603.pepYLTSHAGMDVAQVDEMLNKKSGLLGISELSNDCRTLEIAADEGHEGARLALEVMTYRLAK|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||| a603YLTSHAGLDVAQVDEMLNKKSGLLGISELSNDCRTLEIAADEGHEGARLALEVMTYRLAK       310       320       330       340       350       360       370       380       390       400       410       420 m603.pepYIASMAVGCGGVDALVFTGGIGENSRNIRAKTVSYLDFLGLHIDTKANMEKRYGNSGIIS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a603YIASMAVGCGGVDALVFIGGIGENSRNIRAKTVSYLDFLGLHIDTKANMEKRYGNSGIIS       370       380       390       400       410       420       430       440       450 m603.pep PTDSSPAVLVVPTNEELMIACDTAELAGILX||||||||||||||||||||||||||:|||| a603 PTDSSPAVLVVPTNEELMIACDTAELVGILX       430       440       450The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1901>:

g604.seq 1 ATGCCCGAAG CGCACTTCTT TACGCGTTCC GCCGCCTGCG GCAAGGTTGA 51CCAGCGTACC GAGCACGGCG GCGGCGATGG CGACCGAGGC GATGCCCATC 101ATAGCGTGGT GCAGTTTGCC CATGCTCAGG GCGCGTACCG GCAAATCGAT 151GTCGGCGGCG TTTACGGTTT TGCCGCTGGA GGCGGTGTAA TCGGCGGCGG 201GCGCGACGAA GGCGGGTTTC GGCGTGCGCG CGCGGGCGGC GGCTTCGGAT 251ACGTCGCTGA TCAAACCCAT TTTCAGCGCG CCATATGCGC GGATGGTTTC 301AAATTTTTCC AGCGCGGCGG CATCGTTGTT GATGTCGTCC TGCAACTCTT 351TGCCCGTGTA GCCCAAGTCG GCGGCGTTCA GGAAAACGGT CGGAATGCCC 401GCGTTGATGA GCGTGGCTTT CAGACGACCT ATATTCGGCA CATCAATTTC 451GTCGACCAAA TTGCCGGTTG GGAACATACT GCCTTcgcCG TCGGCTGGAT 501 CTAAThis corresponds to the amino acid sequence <SEQ ID 1902; ORF 604.ng>:

g604.pep 1 MPEAHFFTRS AACGKVDQRT EHGGGDGDRG DAHHSVVQFA HAQGAYRQID 51VGGVYGFAAG GGVIGGGRDE GGFRRARAGG GFGYVADQTH FQRAICADGF 101KFFQRGGIVV DVVLQLFARV AQVGGVQENG RNARVDERGF QTTYIRHINF 151VDQIAGWEHT AFAVGWI*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1903>:

m604.seq 1 ATGCCCGAAG CGCACTTCTT TACGCGTTCC GCCGCCTGCG GCAAGGTTGA 51CCAGCGTACC GGGTACGGCG GCGGCGGTCG CAATGGCAAC AGAGGCGGTA 101CCCATCATCG CGTGGTGCAG TTTGCCCATG CTCAGGGCGC GTACCAGCAA 151ATCGATGTCG GCGGCGTTCA CGGTTTTGCC ACTGGAGGCG GTGTAATCGG 201CGGCGGGCGC GACGAAGGCG ACTTTCGGCG TGTGCGCGCG AGCGGCAGCT 251TCGGATACGT CGCTGATCAG ACCCATTTTC AGCGCACCGT AAGCGCGGAT 301TTTCTCGAAT TTTTCCAAAG CCGCGGCATC GTTGTTGATG TCGTCTTGCA 351ACTCTTTGCC TGTGTAGCCC AAGTCGGCGG CATTCAAGAA AACGGTCGGA 401ATGCCCGCGT TGATGAGCGT GGCTTTCAAA CGGCCTATAT TCGGCACATC 451AATTTCATCG ACCAAATTGC CGGTTGGGAA CATACTGCCT TCGCCGTCGG 501 CTGGATCThis corresponds to the amino acid sequence <SEQ ID 1904; ORF 604>:

m604.pep 1 MPEAHFFTRS AACGKVDQRT GYGGGGRNGN RGGTHHRVVQ FAHAQGAYQQ 51IDVGGVHGFA TGGGVIGGGR DEGDFRRVRA SGSFGYVADQ THFQRTVSAD 101FLEFFQSRGI VVDVVLQLFA CVAQVGGIQE NGRNARVDER GFQTAYIRHI 151NFIDQIAGWE HTAFAVGWIComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 604 shows 83.4% identity over a 169 aa overlap with a predicted ORF(ORF 604.ng) from N. gonorrhoeae:

m604/g604          10        20        30        40        50        60m604.pep  MPEAHFFTRSAACGKVDQRTGYGGGGRNGNRGGTHHRVVQFAHAQGAYQQIDVGGVHGFA |||||||||||||||||||| :|||  :|:|| :|| |||||||||||:|||||||:||| g604 MPEAHFFTRSAACGKVDQRTEHGGG--DGDRGDAHHSVVQFAHAQGAYRQIDVGGVYGFA         10        20        30        40        50         70        80        90       100       110       120 m604.pep TGGGVIGGGRDEGDFRRVRASGSFGYVADQTHFQRTVSADFLEFFQSRGIVVDVVLQLFA :|||||||||||| |||:||:|:||||||||||||:: || ::|||  |||||||||||| g604 AGGGVIGGGRDEGGFRRARAGGGFGYVADQTHFQRAICADGFKFFQRGGIVVDVVLQLFA 60        70        80        90       100       110        130       140       150       160      169 m604.pep CVAQVGGIQENGRNARVDERGFQTAYIRHINFIDQIAGWEHTAFAVGWI  ||||||:||||||||||||||||:|||||||:|||||||||||||||| g604 RVAQVGGVQENGRNARVDERGFQTTYIRHINFVDQIAGWEHTAFAVGWIX120       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1905>:

a604.seq 1 ATGCCCGAAG CGCACTTCTT TACGCGTTCC GCCGCCTGCG GCAAGGTTGA 51CCAGCGTACC GGGCACGGCG GCGGCGGTCG CAATGGCAAC AGAGGCGGTA 101CCCATCATCG CGTGGTGCAA TTTGCCCATG CTCAGGGCGC GTACCAGCAA 151ATCGATGTCG GCGGCATTCA CGGTTTTGCC ACTGGAGGCG GTGTAATCGG 201CGGCGGGCGC GACGAAGGCG ACTTTCGGCG TGTGCGCGCG GGCGGCAGCT 251TCGGATACGT CGCTGATCAG ACCCATTTTC AGCGCACCGT AAGCGCGGAT 301TTTCTCGAAT TTTTCCAAAG CTGCGGCATC GTTGTTGATG TCGTCTTGCA 351ACTCTTTGCC CGTGTAGCCC AAGTCGGCGG CATTCAGGAA AACGGTCGGA 401ATGCCCGCGT TGATGAGCGT GGCTTTCAAA CGGCCTATAT TCGGCACATC 451AATTTCATCG ACCAAATTGC CGGTTGGGAA CATACTGCCT TCGCCGTCGG 501CTGGATCAAG AAATTCGATT TGTACTTCGG CTGCCGGGAA CGTTACGCCG 551TCGAGCTCAA AATCGCCTGT TTCCAAAACT GCGCCGTTTT GCATCGGTAC 601ATGGGCAATA ATGGTTTTGC CGATGTTTTT CTGCCAGATT TTGACTGTGC 651AGATGCCGTC TGAThis corresponds to the amino acid sequence <SEQ ID 1906; ORF 604.a>:

a604.pep 1 MPEAHFFTRS AACGKVDQRT GHGGGGRNGN RGGTHHRVVQ FAHAQGAYQQ 51IDVGGIHGFA TGGGVIGGGR DEGDFRRVRA GGSFGYVADQ THFQRTVSAD 101FLEFFQSCGI VVDVVLQLFA RVAQVGGIQE NGRNARVDER GFQTAYIRHI 151NFIDQIAGWE HTAFAVGWIK KFDLYFGCRE RYAVELKIAC FQNCAVLHRY 201MGNNGFADVF LPDFDCADAV * m604/a604 97.0% identity in 169 aa overlap        10        20        30        40        50        60 m604.pepMPEAHFFTRSAACGKVDQRTGYGGGGRNGNRGGTHHRVVQFAHAQGAYQQIDVGGVHGFA|||||||||||||||||||||:|||||||||||||||||||||||||||||||||:|||| a604MPEAHFFTRSAACGKVDQRTGHGGGGRNGNRGGTHHRVVQFAHAQGAYQQIDVGGIHGFA        10        20        30        40        50        60        70        80        90       100       110       120 m604.pepTGGGVIGGGRDEGDFRRVRASGSFGYVADQTHFQRTVSADFLEFFQSRGIVVDVVLQLFA||||||||||||||||||||:|||||||||||||||||||||||||| |||||||||||| a604TGGGVIGGGRDEGDFRRVRAGGSFGYVADQTHFQRTVSADFLEFFQSCGIVVDVVLQLFA        70        80        90       100       110       120       130       140       150       160      169 m604.pepCVAQVGGIQENGRNARVDERGFQTAYIRHINFIDQIAGWEHTAFAVGWI|||||||||||||||||||||||||||||||||||||||||||||||| a604RVAQVGGIQENGRNARVDERGFQTAYIRHINFIDQIAGWEHTAFAVGWIKKFDLYFGCRE       130       140       150       160       170       180 a604RYAVELKIACFQNCAVLHRYMGNNGFADVFLPDFDCADAVX       190       200       210       220The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 1907>:

g605.seq 1 ATGATGACCG AAATGCAACA ACGCGCCCAA CTGCACCGCC AAATTTGGAA 51AATCGCCGAC GAAGTACGCG GCGCGGTGGA TGGCTGGGAC TTTAAACAAT 101ACGTTCTCGG CACACTTTTC TACCGCTTTA TCAGCGAAAA CTTCACCGAC 151TATATGCAGG CCGGCGACAG CAGCATTGAT TACGCCGCta tGCCGGACAG 201CATCATCACG CCCGAAATCA AAGACGATgc cgtcaaagtc aaAGGCTATT 251TCATCtacCc cgGCCAGCTT TTTTgcaata ttgccgccga agcCCATCAA 301AACGAAGAGC TCAACACCAA GCTGAAAGAa atCTTTACCG CGATTGAAAG 351CTCCGCCTCC GGCTAcccgT CCGAACAAGG CATCAAAGGC TTGTTTGACG 401ACTTCgACAC CACCAGCAGC CGGCTCGGCA GCACCGTTGC CGACAAAAAC 451AAACGCCTTG CCGCCGTCCT TAAAGGCGTG GCGGAACTCG ATTTCGGCAA 501TTTTGAAGAC CACCGCATCG ACCTTTTCGG TGATGCCTAC GAATACCTGA 551TTTCCAACTA CGCcgcCAAC GCAGGCAAAT CCGGCGGCGA ATTTTTCACC 601CCGCAAAGCG TCTCCAAGCT GATTGCGCGG CTGGCGGTGC ACGGGCAGGA 651GAAAGTCAAC AAAATCTACG ACCCCGCCTG CGGCTCGGGC AGCCTGCTCT 701TGCAGGCGAA AAAACAGTTT GACGAACACA TCATCGAAGA AGGCTTCTTC 751GGGCAGGAAA TCAACCACAC CACCTACAAC CTCGCCCGCA TGAATATGTT 801TCTGCACAAC GTCAATTACA ACAAATTCCA CATCGAATTG GGCGACACGC 851TGACCAACCC CAAACTCAAA GACAGCAAAC CCTTTGATGC CGTCGTCTCC 901AATCCGCCCT ATTCCATCGA CTGGATAGGC AGCGACGACC CCACCTtgaT 951CAACGACGAC CGCTTTGCCC CCGCAGGCGT ACTCGCACCG AAATCCAAAG 1001CCGATTTTGC CTTCATCCTG CACGCACTGA ACTACCTTTC CGGCAGAGGC 1051CGCGCCGCTA TCGTCTCATT CCCCGGCATT TTCTATCGCG GCGGCGCAGA 1101GCAGAAAATc CGCCAATATC TGGTGGAGGG CAACTATGTG GAAACCGTGA 1151TTGCCCTTGC GCCCAATCTC TTTTACGGCA CCTGCATCGC CGTCAATATC 1201CTGGTTTTGT CCAAACACAA AGACAATACC GACATCCAAT TCATCGACGC 1251AAGCGGCTTC TTTAAAAAAG AAACCAACAA CAACGTCTTA ACCGAAGAAC 1301ACATTGCCGA AATCGTCAAA CTCTTCGCCG ACAAAGCCGA TGTGCCGCAT 1351ATCGCCCAAA ACGCCGCCCA GCAAACCGTC AAAGACAACG GCTACAACCT 1401CGCCGTCAGC AGCTATGTCG AAGCCGAAGA CACCCGCGAG GTCATCGACA 1451TCAGACAGCT CAACGCCGAA ATCAGCGAAA CCgtcgCcaa AATCGAACGG 1501CTGCGGCGTG AAATTGACGA AGTGATTGCA GAGATTGAAA CCTAGThis corresponds to the amino acid sequence <SEQ ID 1908; ORF 605.ng>:

g605.pep 1 MMTEMQQRAQ LHRQIWKIAD EVRGAVDGWD FKQYVLGTLF YRFISENFTD 51YMQAGDSSID YAAMPDSIIT PEIKDDAVKV KGYFIYPGQL FCNIAAEAHQ 101NEELNTKLKE IFTAIESSAS GYPSEQGIKG LFDDFDTTSS RLGSTVADKN 151KRLAAVLKGV AELDFGNFED HRIDLFGDAY EYLISNYAAN AGKSGGEFFT 201PQSVSKLIAR LAVHGQEKVN KIYDPACGSG SLLLQAKKQF DEHIIEEGFF 251GQEINHTTYN LARMNMFLHN VNYNKFHIEL GDTLTNPKLK DSKPFDAVVS 301NPPYSIDWIG SDDPTLINDD RFAPAGVLAP KSKADFAFIL HALNYLSGRG 351RAAIVSFPGI FYRGGAEQKI RQYLVEGNYV ETVIALAPNL FYGTCIAVNI 401LVLSKHKDNT DIQFIDASGF FKKETNNNVL TEEHIAEIVK LFADKADVPH 451IAQNAAQQTV KDNGYNLAVS SYVEAEDTRE VIDIRQLNAE ISETVAKIER 501LRREIDEVIA EIET*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1909>:

m605.seq 1 ATGATGACCG AAATGCAACA ACGCGCCCAA CTGCACCGCC AAATTTGGAA 51AATTGCCGAC GAAGTACGCG GCGCGGTGGA TGGCTGGGAC TTTAAACAAT 101ACGTTCTCGG CACACTTTTC TACCGCTTTA TCAGCGAAAA CTTCACCGAC 151TATATGCAGG CAGGCGACAG CAGTATTGAT TACGCCGCTA TGCCGGACAG 201CATCATCACG CCCGAAATCA AAGACGATGC CGTCAAAGTT AAAGGCTATT 251TCATCTACCC CGGCCAGCTT TTTTGCAATA TTGCCGCCGA AGCCCATCAA 301AACGAAGAGC TCAACACCAA GCTGAAAGAA ATTTTTACCG CGATTGAAAG 351CTCCGCCTCC GGCTATCCGT CCGAACAGGA CATCAAAGGC CTGTTTGACG 401ACTTCGACAC CACCAGCAGC CGGCTCGGCA GCACTGTTGC CGACAAGAAC 451AAACGCCTTG CCGCCGTCCT CAAAGGCGTG GCGGAACTCG ATTTCGGCAA 501TTTTGAAAAC CACCACATCG ACCTTTTCGG CGATGCCTAC GAATACCTGA 551TTTCCAACTA CGCTGCCAAC GCAGGCAAAT CCGGCGGCGA ATTTTTCACC 601CCGCAAAGCG TATCCAAGCT GATTGCGCGG CTGGCGGTGC ACGGACAGGA 651GAAAGTCAAC AAAATCTACG ACCCAGCTTG CGGCTCGGGC AGTCTGCTCT 701TGCAGGCGAA AAAACAGTTT GACGAGCACA TCATCGAAGA AGGCTTCTTC 751GGGCAGGAAA TCAACCACAC CACCTACAAC CTCGCCCGCA TGAACATGTT 801CCTGCACAAC GTCAATTACA ACCAATTCCA CATCGAATTG GGCGACACAC 851TGACCAACCC AAAGCTCAAA GACAGCAAAC CCTTTGATGC CATCGTTTCC 901AATCCGCCTT ATTCCATCAA CTGGATAGGC AGCGACGACC CCACCTTAAT 951CAACGACGAC CGCTTTGCCC CCGCAGGCGT ACTTGCCCCG AAATCCAAAG 1001CCGATTTTGC CTTCATCCTG CACGCACTGA ACTACCTTTC CGGCAGAGGC 1051CGCGCCGCCA TCGTCTCATT CCCCGGCATT TTCTATCGCG GCGGCGCAGA 1101ACAGAAAATC CGCCAATATC TGGTGGAGGG CAACTACGTG GAAACCGTGA 1151TTGCCCTTGC GCCCAATCTC TTTTACGGCA CCGGCATCGC CGTCAATATC 1201CTGGTTTTGT CCAAACACAA AGACAATACC GACATCCAAT TCATCGACGC 1251AAGCGGCTTC TTTAAAAAAG AAACCAACAA CAACGTCTTA ATCGAAGAAC 1301ACATTGCTGA AATCGTCAAA CTCTTCGCCG ATAAAGCCGA TGTGCCGCAT 1351ATCGCCCAAA ACGCTGCCCA GCAAACCGTC AAAGACAACG GCTACAACCT 1401CGCCGTCAGC AGCTATGTCG AAGCCGAAGA CACACGCGAA ATTATCGACA 1451TCAAACAGCT CAACGCCGAA ATCGGCGAAA CCGTCGCCAA AATCGAACGG 1501CTGCGGCGTG AAATTGACGA AGTGATTGCA GAGATTGAAG CATGAThis corresponds to the amino acid sequence <SEQ ID 1910; ORF 605>:

m605.pep 1 MMTEMQQRAQ LHRQIWKIAD EVRGAVDGWD FKQYVLGTLF YRFISENFTD 51YMQAGDSSID YAAMPDSIIT PEIKDDAVKV KGYFIYPGQL FCNIAAEAHQ 101 NEELNTKLKEIFTAIESSAS GYPSEQDIKG LFDDFDTTSS RLGSTVADKN 151 KRLAAVLKGV AELDFGNFENHHIDLFGDAY EYLISNYAAN AGKSGGEFFT 201 PQSVSKLIAR LAVHGQEKVN KIYDPACGSGSLLLQAKKQF DEHIIEEGFF 251 GQEINHTTYN LARMNMFLHN VNYNQFHIEL GDTLTNPKLKDSKPFDAIVS 301 NPPYSINWIG SDDPTLINDD RFAPAGVLAP KSKADFAFIL HALNYLSGRG351 RAAIVSFPGI FYRGGAEQKI RQYLVEGNYV ETVIALAPNL FYGTGIAVNI 401LVLSKHKDNT DIQFIDASGF FKKETNNNVL IEEHIAEIVK LFADKADVPH 451 IAQNAAQQTVKDNGYNLAVS SYVEAEDTRE IIDIKQLNAE IGETVAKIER 501 LRREIDEVIA EIEA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 605 shows 97.9% identity over a 513 aa overlap with a predicted ORF(ORF 605.ng) from N. gonorrhoeae:

m605/g605         10        20        30        40        50        60m605.pep MMTEMQQRAQLHRQIWKIADEVRGAVDGWDFKQYVLGTLFYRFISENFTDYMQAGDSSID|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g605MMTEMQQRAQLHRQIWKIADEVRGAVDGWDFKQYVLGTLFYRFISENFTDYMQAGDSSID        10        20        30        40        50        60        70        80        90       100       110       120 m605.pepYAAMPDSIITPEIKDDAVKVKGYFIYPGQLFCNIAAEAHQNEELNTKLKEIFTAIESSAS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g605YAAMPDSIITPEIKDDAVKVKGYFIYPGQLFCNIAAEAHQNEELNTKLKEIFTAIESSAS        70        80        90       100       110       120       130       140       150       160       170       180 m605.pepGYPSEQDIKGLFDDFDTTSSRLGSTVADKNKRLAAVLKGVAELDFGNFENHHIDLFGDAY|||||| ||||||||||||||||||||||||||||||||||||||||||:|:|||||||| g605GYPSEQGIKGLFDDFDTTSSRLGSTVADKNKRLAAVLKGVAELDFGNFEDHRIDLFGDAY       130       140       150       160       170       180       190       200       210       220       230       240 m605.pepEYLISNYAANAGKSGGEFFTPQSVSKLIARLAVHGQEKVNKIYDPACGSGSLLLQAKKQF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g605EYLISNYAANAGKSGGEFFTPQSVSKLIARLAVHGQEKVNKIYDPACGSGSLLLQAKKQF       190       200       210       220       230       240       250       260       270       280       290       300 m605.pepDEHIIEEGFFGQEINHTTYNLARMNMFLHNVNYNQFHIELGDTLTNPKLKDSKPFDAIVS||||||||||||||||||||||||||||||||||:||||||||||||||||||||||:|| g605DEHIIEEGFFGQEINHITYNLARMNMFLHNVNYNKFHIELGDTLINPKLKDSKPFDAVVS       250       260       270       280       290       300       310       320       330       340       350       360 m605.pepNPPYSINWIGSDDPTLINDDRFAPAGVLAPKSKADFAFILHALNYLSGRGRAAIVSFPGI||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||| g605NPPYSIDWIGSDDPILINDDRFAPAGVLAPKSKADFAFILHALNYLSGRGRAAIVSFPGI       310       320       330       340       350       360       370       380       390       400       410       420 m605.pepFYRGGAEQKIRQYLVEGNYVETVIALAPNLFYGTGIAVNILVLSKHKDNTDIQFIDASGF|||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||| g605FYRGGAEQKIRQYLVEGNYVETVIALAPNLFYGTCIAVNILVLSKHKDNTDIQFIDASGF       370       380       390       400       410       420       430       440       450       460       470       480 m605.pepFKKETNNNVLIEEHIAEIVKLFADKADVPHIAQNAAQQTVKDNGYNLAVSSYVEAEDTRE|||||||||| ||||||||||||||||||||||||||||||||||||||||||||||||| g605FKKETNNNVLTEEHIAEIVKLFADKADVPHIAQNAAQQTVKDNGYNLAVSSYVEAEDTRE       430       440       450       460       470       480       490       500       510 m605.pepIIDIKQLNAEIGETVAKIERLRREIDEVIAEIEAX :|||:||||||:|||||||||||||||||||||:g605 VIDIRQLNAEISETVAKIERLRREIDEVIAEIETX        490       500       510The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1911>:

a605.seq 1 ATGATGACCG AAATACAACA ACGCGCCCAA CTGCACCGCC AAATTTGGAA 51AATTGCCGAC GAAGTACGCG GCGCGGTGGA TGGCTGGGAC TTCAAACAAT 101 ACGTTCTCGGCACACTTTTC TACCGCTTTA TCAGCGAAAA CTTTACCGAC 151 TATATGCAGG CAGGCGACAGCAGTATTGAT TACGCCGCTA TGCCGGACAG 201 CATCATCACG CCCGAAATCA AAGACGATGCCGTCAAAGTC AAAGGCTATT 251 TCATCTACCC CGGCCAGCTT TTTTGCAATA TTGCCGCCGAAGCCCATCAA 301 AACGAAGAGC TCAACACCAA GCTGAAAGAA ATTTTTACCG CGATTGAAAG351 CTCCGCCTCC GGCTATCCGT CCGAACAAGA CATTAAAGGC CTGTTTGACG 401ACTTCGACAC CACCAGCAGC CGGCTCGGCA GCACCGTTGC CGACAAGAAC 451 AAACGCCTTGCCGCCGTCCT AAAAGGCGTG GCGGAACTCG ATTTCGGCAG 501 TTTTGAAGAC CACCACATCGACCTTTTCGG CGATGCCTAC GAATACCTGA 551 TTTCCAACTA CGCTGCCAAC GCAGGCAAATCCGGCGGCGA ATTTTTCACC 601 CCGCAAAGCG TATCCAAGCT GATTGCGCGG CTGGCGGTGCACGGGCAGGA 651 GAAAGTAAAC AAAATCTACG ACCCAGCTTG CGGCTCGGGC AGCCTGCTCT701 TGCAGGCGAA AAAACAGTTT GACGAGCACA TCATCGAAGA AGGCTTCTTC 751GGGCAGGAAA TCAACCACAC CACCTACAAC CTCGCCCGCA TGAATATGTT 801 TCTGCACAACGTCAATTACA ACAAATTCCA CATCGAATTG GGCGACACAC 851 TGACCAATCC CAAACTCAAAGACAGCAAAC CCTTTGATGC CGTCGTTTCC 901 AATCCGCCCT ATTCCATCAA CTGGATAGGCAGCGGCGACC CCACCTTAAT 951 CAACGACGAC CGCTTTGCCC CTGCAGGCGT ACTCGCCCCGAAATCCAAAG 1001 CCGATTTTGC CTTCATTCTG CACGCACTGA ACTACCTTTC CGGCAGAGGC1051 CGCGCCGCCA TCGTCTCATT CCCCGGCATT TTCTATCGCG GCGGCGCAGA 1101GCAGAAAATC CGCCAATATC TGGTGGAGGG CAACTACGTG GAAACCGTCA 1151 TCGCCCTTGCGCCCAATCTC TTTTACGGCA CCGGCATCGC CGTCAATATA 1201 CTGGTTTTGT CCAAACACAAAGACAATACC GACATCCAAT TCATCGACGC 1251 AGGCGGCTTC TTTAAAAAAG AAACCAACAACAACGTCTTA ACCGAAGAAC 1301 ACATTGCCGA AATCGTCAAA CTCTTCGCCG ATAAAGCCGATGTGCCGCAT 1351 ATCGCCCAAA ACGCCGCCCA GCAAACCGTC AAAGACAACG GCTACAACCT1401 CGCCGTCAGC AGCTATGTTG AACCCGAAGA CACCCGCGAA ATTATCGACA 1451TCAAACAGCT TAACGCCGAA ATCAGCGAAA CCGTTGCCAA AATCGAACGG 1501 CTGCGGCGTGAAATTGACGA AGTGATTGCA GAGATTGAAG CATGAThis corresponds to the amino acid sequence <SEQ ID 1912; ORF 605.a>:

a605.pep 1 MMTEIQQRAQ LHRQIWKIAD EVRGAVDGWD FKQYVLGTLF YRFISENFTD 51YMQAGDSSID YAAMPDSIIT PEIKDDAVKV KGYFIYPGQL FCNIAAEAHQ 101 NEELNTKLKEIFTAIESSAS GYPSEQDIKG LFDDFDTTSS RLGSTVADKN 151 KRLAAVLKGV AELDFGSFEDHHIDLFGDAY EYLISNYAAN AGKSGGEFFT 201 PQSVSKLIAR LAVHGQEKVN KIYDPACGSGSLLLQAKKQF DEHIIEEGFF 251 GQEINHTTYN LARMNMFLHN VNYNKFHIEL GDTLTNPKLKDSKPFDAVVS 301 NPPYSINWIG SGDPTLINDD RFAPAGVLAP KSKADFAFIL HALNYLSGRG351 RAAIVSFPGI FYRGGAEQKI RQYLVEGNYV ETVIALAPNL FYGTGIAVNI 401LVLSKHKDNT DIQFIDAGGF FKKETNNNVL TEEHIAEIVK LFADKADVPH 451 IAQNAAQQTVKDNGYNLAVS SYVEPEDTRE IIDIKQLNAE ISETVAKIER 501 LRREIDEVIA EIEA*m605/a605 98.1% identity in 514 aa overlap        10        20        30        40        50        60 m605.pepMMTEMQQRAQLHRQIWKIADEVRGAVDGWDFKQYVLGTLFYRFISENFTDYMQAGDSSID||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||| a605MMTEIQQRAQLHRQIWKIADEVRGAVDGWDFKQYVLGTLFYRFISENFIDYMQAGDSSID        10        20        30        40        50        60        70        80        90       100       110       120 m605.pepYAAMPDSIITPEIKDDAVKVKGYFIYPGQLFCNIAAEAHQNEELNTKLKEIFTAIESSAS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a605YAAMPDSIITPEIKDDAVKVKGYFIYPGQLFCNIAAEAHQNEELNTKLKEIFTAIESSAS        70        80        90       100       110       120       130       140       150       160       170       180 m605.pepGYPSEQDIKGLFDDFDTTSSRLGSTVADKNKRLAAVLKGVAELDFGNFENHHIDLFGDAY||||||||||||||||||||||||||||||||||||||||||||||:||:|||||||||| a605GYPSEQDIKGLFDDFDTTSSRLGSTVADKNKRLAAVLKGVAELDFGSFEDHHIDLFGDAY       130       140       150       160       170       180       190       200       210       220       230       240 m605.pepEYLISNYAANAGKSGGEFFTPQSVSKLIARLAVHGQEKVNKIYDPACGSGSLLLQAKKQF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a605EYLISNYAANAGKSGGEFFTPQSVSKLIARLAVHGQEKVNKIYDPACGSGSLLLQAKKQF       190       200       210       220       230       240       250       260       270       280       290       300 m605.pepDEHIIEEGFFGQEINHTTYNLARMNMFLHNVNYNQFHIELGDTLTNPKLKDSKPFDAIVS||||||||||||||||||||||||||||||||||:||||||||||||||||||||||:|| a605DEHIIEEGFFGQEINHITYNLARMNMFLHNVNYNKFHIELGDTLINPKLKDSKPFDAVVS       250       260       270       280       290       300       310       320       330       340       350       360 m605.pepNPPYSINWIGSDDPTLINDDRFAPAGVLAPKSKADFAFILHALNYLSGRGRAAIVSFPGI||||||||||| |||||||||||||||||||||||||||||||||||||||||||||||| a605NPPYSINWIGSGDPILINDDRFAPAGVLAPKSKADFAFILHALNYLSGRGRAAIVSFPGI       310       320       330       340       350       360       370       380       390       400       410       420 m605.pepFYRGGAEQKIRQYLVEGNYVETVIALAPNLFYGTGIAVNILVLSKHKDNTDIQFIDASGF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| a605FYRGGAEQKIRQYLVEGNYVETVIALAPNLFYGTGIAVNILVLSKHKDNTDIQFIDAGGF       370       380       390       400       410       420       430       440       450       460       470       480 m605.pepFKKETNNNVLIEEHIAEIVKLFADKADVPHIAQNAAQQTVKDNGYNLAVSSYVEAEDTRE|||||||||| ||||||||||||||||||||||||||||||||||||||||||| ||||| a605FKKETNNNVLTEEHIAEIVKLFADKADVPHIAQNAAQQTVKDNGYNLAVSSYVEPEDTRE       430       440       450       460       470       480       490       500       510 m605.pepIIDIKQLNAEIGETVAKIERLRREIDEVIAEIEAX |||||||||||:|||||||||||||||||||||||a605 IIDIKQLNAEISETVAKIERLRREIDEVIAEIEAX        490       500       510The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 1913>:

g606.seq 1 ATGTCCAAAT TTATCGCCAA ACAATCGGTC GGTGCGGAAG TCATCGACAC 51GCCGcgCACC GAAGAAGAAG CCTGGCTTCT GAACACTGTC GAAGCCCAAg 101 cgcGGCAATGGAATCTGAAA ACGCCAGAAG TCGCCATCTA CCACTCCCCC 151 GAACCCAATG CCTTTGCCACGGGCGCATCG AGAAACAGCT CCCTGATCGC 201 CGTCAGCacc ggtttgctcg accaTAtgaCGCGCGACgaa gtggaagccg 251 tgTTGGCGCA CGAAATGGCG CACGTCGGCA ACGGCGACATGGTTACGCTG 301 ACGCTGAtTC AAGGCGTGGT CAATACCTTT GTCGTGTTCC TGTCGCGCAT351 TATTGCCAAC CTGATTGCCC GAAACAACGA CGGCAGCCAG TCCCAGGGAA 401CTTATTTCCT AGTCAGCATG GTATTCCAAA TCCTGTTCGG CTTCCTTGCC 451 AGCCTGATTGTCATGTGGTT CAGCCGCCAA CGCGAATACC GCGCCGAcgc 501 gggCGcggCA AAACTGGTCGGCGCACCGAA AATGATTTCC GCCCTGCAAA 551 GGCTTAAAGG CAACCCGGTC GATTTGCCCGAAGAAATGAA CGCAATGGGC 601 ATCGCCGGAG ATACGCGCGA CTCCCTGCTC AGCACCCACCCTTCGCTGGA 651 CAACCGAATC GCCCGCCTCA AATCGCTTTA AThis corresponds to the amino acid sequence <SEQ ID 1914; ORF606.ng>:

g606.pep 1 MSKFIAKQSV GAEVIDTPRT EEEAWLLNTV EAQARQWNLK TPEVAIYHSP 51EPNAFATGAS RNSSLIAVST GLLDHMTRDE VEAVLAHEMA HVGNGDMVTL 101TLIQGVVNTF VVFLSRIIAN LIARNNDGSQ SQGTYFLVSM VFQILFGFLA 151 SLIVMWFSRQREYRADAGAA KLVGAPKMIS ALQRLKGNPV DLPEEMNAMG 201 IAGDTRDSLL STHPSLDNRIARLKSL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1915>:

m606.seq 1 ATGTCCAAAT TTATCGCCAA ACAATCGGTC GGCGCGGAAG TTATCGACAC 51GCCGCGCACC GAAGAAGAAG CCTGGCTTTT GAACACTGTC GAAGCCCAAG 101 CGCGGCAATGGAACCTGAAA ACGCCCGAAG TCGCCATCTA CCACTCCCCC 151 GAACCCAATG CCTTTGCCACGGGCGCATCG AGAAACAGCT CCCTGATCGC 201 CGTCAGCACC GGTTTGCTCG ACCATATGACGCGTGACGAA GTGGAAGCCG 251 TATTGGCGCA CGAAATGGCA CACGTCGGCA ACGGCGATATGGTTACGCTG 301 ACGCTGATTC AAGGCGTGGT CAATACCTTT GTCGTGTTCC TGTCGCGCAT351 TATTGCCAAC CTGATTGCCC GAAACAACGA CGGCAGCCAG TCCCAGGGAA 401CTTATTTCCT GGTCAGCATG GTATTCCAAA TCCTGTTCGG CTTCCTTGCC 451 AGCTTAATTGTCATGTGGTT CAGCCGACAA CGCGAATACC GCGCCGATGC 501 GGGCGCGGCA AAACTGGTCGGCGCGCCGAA AATGATTTCC GCCCTGCAAA 551 GGCTCAAAGG CAACCCGGTC GATTTGCCCGAAGAAATGAA CGCAATGGGC 601 ATCGCCGGAG ATACGCGCGA CTCCCTGCTC AGCACCCACCCTTCGCTGGA 651 CAACCGTATC GCCCGCCTCA AATCGCTTTA AThis corresponds to the amino acid sequence <SEQ ID 1916; ORF 606>:

m606.pep 1 MSKFIAKQSV GAEVIDTPRT EEEAWLLNTV EAQARQWNLK TPEVAIYHSP 51EPNAFATGAS RNSSLIAVST GLLDHMTRDE VEAVLAHEMA HVGNGDMVTL 101TLIQGVVNTF VVFLSRIIAN LIARNNDGSQ SQGTYFLVSM VFQILFGFLA 151 SLIVMWFSRQREYRADAGAA KLVGAPKMIS ALQRLKGNPV DLPEEMNAMG 201 IAGDTRDSLL STHPSLDNRIARLKSL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 606 shows 100.0% identity over a 225 aa overlap with a predicted ORF(ORF 606.ng) from N. gonorrhoeae:

m606/g606         10        20        30        40        50        60m606.pep MSKFIAKQSVGAEVIDTPRTEEEAWLLNTVEAQARQWNLKTPEVAIYHSPEPNAFATGAS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g606MSKFIAKQSVGAEVIDTPRTEEEAWLLNTVEAQARQWNLKTPEVAIYHSPEPNAFATGAS        10        20        30        40        50        60        70        80        90       100       110       120 m606.pepRNSSLIAVSTGLLDHMTRDEVEAVLAHEMAHVGNGDMVTLTLIQGVVNTFVVFLSRIIAN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g606RNSSLIAVSTGLLDHMTRDEVEAVLAHEMAHVGNGDMVTLTLIQGVVNTFVVFLSRIIAN        70        80        90       100       110       120       130       140       150       160       170       180 m606.pepLIARNNDGSQSQGTYFLVSMVFQILFGFLASLIVMWFSRQREYRADAGAAKLVGAPKMIS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g606LIARNNDGSQSQGTYFLVSMVFQILFGFLASLIVMWFSRQREYRADAGAAKLVGAPKMIS       130       140       150       160       170       180       190       200       210       220 m606.pepALQRLKGNPVDLPEEMNAMGIAGDTRDSLLSTHPSLDNRIARLKSLX||||||||||||||||||||||||||||||||||||||||||||||| g606ALQRLKGNPVDLPEEMNAMGIAGDTRDSLLSTHPSLDNRIARLKSLX       190       200       210       220The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1917>:

a606.seq 1 ATGTCCAAAT TCATCGCCAA ACAATCGGTC GGCGCGGAAG TTATCGACAC 51GCCGCGCACC GAAGAAGAAG CCTGGCTTTT GAACACTGTC GAAGCCCAAG 101 CGCGGCAATGGAACCTGAAA ACGCCCGAAG TCGCCATCTA CCACTCCCCC 151 GAACCCAATG CCTTTGCCACGGGCGCATCG AGAAACAGCT CCCTGATCGC 201 CGTCAGCACC GGTTTGCTCG ACCATATGACGCGTGACGAA GTGGAAGCCG 251 TATTGGCGCA CGAAATGGCA CACGTCGGCA ACGGCGATATGGTTACGCTG 301 ACGCTGATTC AAGGCGTGGT CAATACCTTT GTCGTGTTCC TGTCGCGCAT351 TATTGCCAAC CTGATTGCCC GAAACAACGA CGGCAGCCAG TCCCAGGGAA 401CTTATTTCCT GGTCAGCATG GTATTCCAAA TCCTGTTCGG CTTCCTTGCC 451 AGCTTAATTGTCATGTGGTT CAGCCGACAA CGCGAATACC GCGCCGACGC 501 GGGCGCGGCA AAACTGGTCGGCGCGCCGAA AATGATTTCC GCCCTGCAAA 551 GGCTTAAAGG CAACCCGGTC GATTTGCCCGAAGAAATGAA CGCAATGGGC 601 ATCGCCGGAG ATACGCGCGA CTCCCTGCTC AGCACCCACCCTTCGCTGGA 651 CAACCGAATC GCCCGCCTCA AATCGCTTTA AThis corresponds to the amino acid sequence <SEQ ID 1918; ORF 606.a>:

a606.pep 1 MSKFIAKQSV GAEVIDTPRT EEEAWLLNTV EAQARQWNLK TPEVAIYHSP 51EPNAFATGAS RNSSLIAVST GLLDHMTRDE VEAVLAHEMA HVGNGDMVTL 101TLIQGVVNTF VVFLSRIIAN LIARNNDGSQ SQGTYFLVSM VFQILFGFLA 151 SLIVMWFSRQREYRADAGAA KLVGAPKMIS ALQRLKGNPV DLPEEMNAMG 201 IAGDTRDSLL STHPSLDNRIARLKSL* m606/a606 100.0% identity in 226 aa overlap        10        20        30        40        50        60 m606.pepMSKFIAKQSVGAEVIDTPRTEEEAWLLNTVEAQARQWNLKTPEVAIYHSPEPNAFATGAS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a606MSKFIAKQSVGAEVIDTPRTEEEAWLLNTVEAQARQWNLKTPEVAIYHSPEPNAFATGAS        10        20        30        40        50        60        70        80        90       100       110       120 m606.pepRNSSLIAVSTGLLDHMTRDEVEAVLAHEMAHVGNGDMVTLTLIQGVVNTFVVFLSRIIAN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a606RNSSLIAVSTGLLDHMTRDEVEAVLAHEMAHVGNGDMVTLTLIQGVVNTFVVFLSRIIAN        70        80        90       100       110       120       130       140       150       160       170       180 m606.pepLIARNNDGSQSQGTYFLVSMVFQILFGFLASLIVMWFSRQREYRADAGAAKLVGAPKMIS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a606LIARNNDGSQSQGTYFLVSMVFQILFGFLASLIVMWFSRQREYRADAGAAKLVGAPKMIS       130       140       150       160       170       180       190       200       210       220 m606.pepALQRLKGNPVDLPEEMNAMGIAGDTRDSLLSTHPSLDNRIARLKSLX||||||||||||||||||||||||||||||||||||||||||||||| a606ALQRLKGNPVDLPEEMNAMGIAGDTRDSLLSTHPSLDNRIARLKSLX       190       200       210       220The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1919>:

g607.seq 1 ATGCTGCTCG accTcgaCCG CTTTTCCTtt tccGTCTTCC TGAAAGAAAT 51CCGCCTGCTG ACCGCCCTTG CCCTGCCCAT GCTGTTGGCG CAGGTCGCGC 101 AGGTGGGCATCGGTTTCGTC GATACCGTGA TGGCGGGCGG TGCGGGCAAG 151 GAAGATTTGG CGGCGGTGGCTTTGGGCAGC AGCGCGTTTG CCACGGTTTA 201 TATTACCTTT ATGGGCATTA TGGCGGCGCTGAACCCGATG ATTGCCCAGC 251 TTTACGGCGC GGGTAAAACC GgtgAAGCAG GCGAAACGGGGCGGCAGGGG 301 ATTTGGTTCG GGCTGATTTT GGGGATTTTC GGCATGATTT TGATGTGGGC351 GGCGATTACG CCGTTCCGCA ACTGGCTGAC TTTGAGCGAT TATGTGGAAG 401gcacAAtggc gcAGTATATG CTGTTCACCA GCTTGGCGAT GCCGGCGGCA 451 ATGGTACACCGCGCACTGCA CGCCTACGCT TCCAGCCTGA ACCGCCCGCG 501 CCTGATTATG TTGGTCAGCTTTGCGGCGTT TGTGTTGAAC GTGCCGCTGA 551 ACTATATTTT CGTTTACGGC AAATTCGGTATGCCCGCTTT GGGTGGCGCA 601 GGTTGCGGCG TGGCGACAAT GGCGGTGTTT TGGTTCAGCGCGCTGGCATT 651 GTGGATTTAT ATCGCCAAGG AAAAATTCTT CCGCCCGTTC GGACTGACAG701 CGAAATTCGg caaACCGGat tGGgcGGTGT TCAAACAGAT TtGGAAAATC 751gGcgcgCCCA TCGGGCTGTC TTATTTTTTG GAAgccaGcg cGTTTTCGTT 801 TATCGTGTTTTTGATTGCGC CTttcggCGA GGATTATGTG GCGGCGCAGC 851 AGGTCGGCAT CAGTTTGTCGGGGATTCTCT ATATGATTCC GCAAAGCGTC 901 GGCTCGGCAG GGACGGTGCG CATCGGCTTTTCGCTTGGGC GGCGCGAATT 951 TTCGCGGGCG CGTTATATTT CAGGAGTGTC GCTGGTGTCGGGCTGGGTGC 1001 TCGCCGTGAT TACCGTGCTT TCCTTGGTAT TATTCCGTTC GCCGCTGGCA1051 AGCATGTACA ACGATGaTCC GGCAGTTTTA AGCATCGCCT CCACCGTCCT 1101GCTGTTCGCC GGCCTGTtcc aACCGGCAGA CTTCACCCAA TGTATCGCGT 1151 CCTATGCCCTGCGCGGCTAC AAAGTCACCA AGGTGCCGAT GTTCATCCAC 1201 GCCGCCGCCT TCTGGGGCTGCGGCCTGCTG CCGGGCTATC TGCTCGCCTA 1251 CCGTTTCGAT ATGGGCATTT ACGGCTTCTGGACGGCATTG ATTGCCTCGC 1301 TCACCATCGC AGCCGTCGCC TTGGTGTGGT GCTTGGAAAAATACAGTATG 1351 GAGTTGGTCA AATCACACAA GGCCGTCTGAThis corresponds to the amino acid sequence <SEQ ID 1920; ORF 607.ng>:

g607.pep 1 MLLDLDRFSF SVFLKEIRLL TALALPMLLA QVAQVGIGFV DTVMAGGAGK 51EDLAAVALGS SAFATVYITF MGIMAALNPM IAQLYGAGKT GEAGETGRQG 101IWFGLILGIF GMILMWAAIT PFRNWLTLSD YVEGTMAQYM LFTSLAMPAA 151 MVHRALHAYASSLNRPRLIM LVSFAAFVLN VPLNYIFVYG KFGMPALGGA 201 GCGVATMAVF WFSALALWIYIAKEKFFRPF GLTAKFGKPD WAVFKQIWKI 251 GAPIGLSYFL EASAFSFIVF LIAPFGEDYVAAQQVGISLS GILYMIPQSV 301 GSAGTVRIGF SLGRREFSRARYISGVSLVS GWVLAVITVL SLVLFRSPLA 351 SMYNDDPAVL SIASTVLLFA GLFQPADFTQCIASYALRGY KVTKVPMFIH 401 AAAFWGCGLL PGYLLAYRFDMGIYGFWTAL IASLTIAAVA LVWCLEKYSM 451 ELVKSHKAV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1921>:

m607.seq 1 ATGCTGCTCG ACCTCAACCG CTTTTCCTTT CCCGTCTTCC TGAAAGAAGT 51CCGCCTGCTG ACCACTCTTG CCCTGCCCAT GCTGTTGGCG CAGGTCGCGC 101 AGGTGGGCATCGGTTTTGTC GATACTGTGA TGGCGGGCGG TGCGGGCAAG 151 GAAGACTTGG CGGCGGTGGCTTTGGGCAGC AGCGCGTTTG CCACGGTTTA 201 TATTACCTTT ATGGGCATTA TGGCGGCGCTGAACCCGATG ATTGCCCAGC 251 TTTACGGCGC GGGTAAAACC GACGAAGTGG GCGAAACGGGGCGGCAGGGG 301 ATTTGGTTCG GGCTGTTTTT GGGCGTGTTC GGCATGGTCT TGATGTGGGC351 GGCGATTACG CCGTTCCGCA ACTGGCTGAC CTTGAGCGAT TATGTGGAAG 401GCACGATGGC GCAGTATATG TTGTTCACCA GCTTGGCGAT GCCGGCGGCA 451 ATGGTACACCGCGCGCTGCA CGCCTACACT TCCAGCCTGA ACCGCCCGCG 501 CCTGATTATG TTGGTCAGCTTTGCGGCGTT TGTGTTGAAC GTGCCGCTGA 551 ACTATATTTT CGTTTACGGC AAATTCGGTATGCCCGCTTT GGGCGGCGCA 601 GGCTGCGGAC TGGCGACGAT GGCGGTGTTT TGGTTCAGCGCGCTGGCATT 651 GTGGATTTAT ATCGCCAAGG AAAATTTCTT CCGCCCATTC GGACTGACGG701 CGAAATTCGG CAAACCGGAT TGGGCGGTGT TCAAACAGAT TTGGAAAATC 751GGCGCACCCA TCGGGCTGTC TTATTTTTTG GAAGCCAGCG CGTTTTCGTT 801 TATCGTGTTTTTGATTGCGC CTTTCGGCGA GGATTATGTG GCGGCGCAGC 851 AGGTCGGCAT CAGTTTGTCGGGGATTCTCT ATATGATTCC GCAAAGCGTC 901 GGCTCGGCGG GGACGGTGCG CATCGGCTTTTCGCTTGGGC GGCGCGAATT 951 TTCGCGGGCG CGTTATATTT CGGGCGTGTC ACTGGTGTTAGGATGGATGC 1001 TCGCCGTGAT TACCGTGCTT TCCTTGGTAT TATTCCGTTC GCCGCTGGTA1051 AGTATGTACA ACAATGATCC GGCGGTTTTA AGCATCGCCG CCACCGTCTT 1101ACTGTTCGCC GGCTTGTTCC AACCGGCAGA CTTCACCCAA TGTATCGCCT 1151 CCTACGCCTTGCGCGGCTAC AAAGTTACAA AGGTGCCGAT GTTCATCCAC 1201 GCCGCCGCCT TTTGGGGCTGCGGCCTGCTG CCGGGCTATC TGCTCGCCTA 1251 CCGTTTCAAT ATGGGCATTT ACGGCTTCTGGACGGCATTG ATTGCCTCGC 1301 TCACCATCGC CGCCATCGCC TTGGTGTGGT GCTTGGAATTGTGCAGTAGG 1351 GAGATGGTCA GATCGCATAA GGCCGTCTGAThis corresponds to the amino acid sequence <SEQ ID 1922; ORF 607>:

m607.pep 1 MLLDLNRFSF PVFLKEVRLL TTLALPMLLA QVAQVGIGFV DTVMAGGAGK 51EDLAAVALGS SAFATVYITF MGIMAALNPM IAQLYGAGKT DEVGETGRQG 101IWFGLFLGVF GMVLMWAAIT PFRNWLTLSD YVEGTMAQYM LFTSLAMPAA 151 MVHRALHAYTSSLNRPRLIM LVSFAAFVLN VPLNYIFVYG KFGMPALGGA 201 GCGLATMAVF WFSALALWIYIAKENFFRPF GLTAKFGKPD WAVFKQIWKI 251 GAPIGLSYFL EASAFSFIVF LIAPFGEDYVAAQQVGISLS GILYMIPQSV 301 GSAGTVRIGF SLGRREFSRARYISGVSLVL GWMLAVITVL SLVLFRSPLV 351 SMYNNDPAVL SIAATVLLFA GLFQPADFTQCIASYALRGY KVTKVPMFIH 401 AAAFWGCGLL PGYLLAYRFNMGIYGFWTAL IASLTIAAIA LVWCLELCSR 451 EMVRSHKAV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 607 shows 94.8% identity over a 459 aa overlap with a predicted ORF(ORF 607.ng) from N. gonorrhoeae:

m607/g607         10        20        30        40        50        60m607.pep MLLDLNRFSFPVFLKEVRLLTTLALPMLLAQVAQVGIGFVDTVMAGGAGKEDLAAVALGS|||||:|||| |||||:||||:|||||||||||||||||||||||||||||||||||||| g607MLLDLDRFSFSVFLKEIRLLTALALPMLLAQVAQVGIGFVDTVMAGGAGKEDLAAVALGS        10        20        30        40        50        60        70        80        90       100       110       120 m607.pepSAFATVYITFMGIMAALNPMIAQLYGAGKTDEVGETGRQGIWFGLFLGVFGMVLMWAAIT|||||||||||||||||||||||||||||| |:||||||||||||:||:|||:||||||| g607SAFATVYITFMGIMAALNPMIAQLYGAGKTGEAGETGRQGIWFGLILGIFGMILMWAAIT        70        80        90       100       110       120       130       140       150       160       170       180 m607.pepPFRNWLTLSDYVEGTMAQYMLFTSLAMPAAMVHRALHAYTSSLNRPRLIMLVSFAAFVLN|||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||| g607PFRNWLTLSDYVEGTMAQYMLFTSLAMPAAMVHRALHAYASSLNRPRLIMLVSFAAFVLN       130       140       150       160       170       180       190       200       210       220       230       240 m607.pepVPLNYIFVYGKFGMPALGGAGCGLATMAVFWFSALALWIYIAKENFFRPFGLTAKFGKPD|||||||||||||||||||||||:||||||||||||||||||||:||||||||||||||| g607VPLNYIFVYGKFGMPALGGAGCGVATMAVFWFSALALWIYIAKEKFFRPFGLTAKFGKPD       190       200       210       220       230       240       250       260       270       280       290       300 m607.pepWAVFKQIWKIGAPIGLSYFLEASAFSFIVFLIAPFGEDYVAAQQVGISLSGILYMIPQSV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g607WAVFKQIWKIGAPIGLSYFLEASAFSFIVFLIAPFGEDYVAAQQVGISLSGILYMIPQSV       250       260       270       280       290       300       310       320       330       340       350       360 m607.pepGSAGTVRIGFSLGRREFSRARYISGVSLVLGWMLAVITVLSLVLFRSPLVSMYNNDPAVL||||||||||||||||||||||||||||| ||:||||||||||||||||:||||:||||| g607GSAGIVRIGFSLGRREFSRARYISGVSLVSGWVLAVITVLSLVLFRSPLASMYNDDPAVL       310       320       330       340       350       360       370       380       390       400       410       420 m607.pepSIAATVLLFAGLFQPADFTQCIASYALRGYKVTKVPMFIHAAAFWGCGLLPGYLLAYRFN|||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||: g607SIASTVLLFAGLFQPADFTQCIASYALRGYKVTKVPMFIHAAAFWGCGLLPGYLLAYRFD       370       380       390       400       410       420       430       440       450       460 m607.pepMGIYGFWTALIASLTIAAIALVWCLELCSREMVRSHKAVX||||||||||||||||||:|||||||  | |:|:|||||| g607MGIYGFWTALIASLTIAAVALVWCLEKYSMELVKSHKAVX       430       440       450       460The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1923>:

a607.seq 1 ATGCTGCTCG ACCTCAACCG CTTTTCCTTT TCCGTCTTCC TGAAAGAAGT 51CCGCCTGCTG ACCGCTCTTG CCCTGCCCAT GCTGTTGGCG CAGGTCGCGC 101 AGGTGGGCATCGGTTTTGTC GATACCGTGA TGGCGGGCGG TGCGGGCAAG 151 GAAGACTTGG CGGCGGTGGCTTTGGGCAGC AGCGCGTTTG CCACGGTTTA 201 TATTACCTTT ATGGGCATTA TGGCGGCGCTGAACCCGATG ATTGCCCAGC 251 TTTACGGCGC GGGTAAAACC GACGAAGTGG GCGAAACGGGACGGCAGGGG 301 ATTTGGTTCG GGCTGTTTTT GGGCGTGTTC GGCATGGTCT TGATGTGGGC351 GGCGATTACG CCGTTCCGCA ACTGGCTGAC CTTGAGCGAT TATGTGGAAG 401GCACAATGGC GCAGTATATG CTGTTCACCA GCTTGGCGAT GCCGGCGGCA 451 ATGGTACACCGCGCACTGCA CGCCTACGCC TCCAGCCTGA ACCGCCCGCG 501 CCTGATTATG TTGGTCAGCTTTGCGGCGTT TGTGTTGAAC GTGCCGCTGA 551 ACTATATTTT CGTTTACGGC AAATTCGGTATGCCCGCTTT GGGCGGCGCA 601 GGCTGCGGAC TGGCGACGAT GGCGGTGTTT TGGTTCAGCGCGCTGGCATT 651 GTGGATTTAT ATCGCCAAGG AAAATTTCTT CCGCCCATTC GGACTGACGG701 CGAAATTCGG CAAACCGGAT TGGGCGGTGT TCAAACAGAT TTGGAAAATC 751GGCGCACCCA TCGGGCTGTC TTATTTTTTG GAAGCCAGCG CGTTTTCGTT 801 TATCGTGTTTTTGATTGCGC CTTTCGGCGA GGATTATGTG GCGGCGCAGC 851 AGGTCGGCAT CAGTTTGTCGGGGATTCTCT ATATGATTCC GCAAAGCGTC 901 GGCTCGGCGG GGACGGTGCG CATCGGCTTTTCGCTTGGGC GGCGCGAATT 951 TTCGCGGGCG CGTTATATTT CGGGCGTGTC ACTGGTGTCAGGATGGATGC 1001 TCGCCGTGAT TACCGTGCTT TCCTTGGTAT TATTCCGTTC GCCGCTGGTA1051 AGTATGTACA ACAATGATCC GGCGGTTTTA AGCATCGCCG CCACCGTCTT 1101ACTGTTCGCC GGCTTGTTCC AACCGGCAGA CTTCACCCAA TGTATCGCCT 1151 CCTACGCCTTGCGCGGCTAC AAAGTTACAA AGGTGCCGAT GTTCATCCAC 1201 GCCGCCGCCT TTTGGGGCTGCGGTCTGCTG CCGGGCTACC TGCTCGCCTA 1251 CCGTTTCGAT ATGGGCATTT ACGGCTTCTGGACGGCATTG ATTGCCTCGC 1301 TCACCATCGC CGCCATCGCC TTGGTGTGGT GCTTGGAATTGTGCAGTAGG 1351 GAGATGGTCA GATCGCATAA GGCTGTCTGAThis corresponds to the amino acid sequence <SEQ ID 1924; ORF 607.a>:

a607.pep 1 MLLDLNRFSF SVFLKEVRLL TALALPMLLA QVAQVGIGFV DTVMAGGAGK 51EDLAAVALGS SAFATVYITF MGIMAALNPM IAQLYGAGKT DEVGETGRQG 101IWFGLFLGVF GMVLMWAAIT PFRNWLTLSD YVEGTMAQYM LFTSLAMPAA 151 MVHRALHAYASSLNRPRLIM LVSFAAFVLN VPLNYIFVYG KFGMPALGGA 201 GCGLATMAVF WFSALALWIYIAKENFFRPF GLTAKFGKPD WAVFKQIWKI 251 GAPIGLSYFL EASAFSFIVF LIAPFGEDYVAAQQVGISLS GILYMIPQSV 301 GSAGTVRIGF SLGRREFSRARYISGVSLVS GWMLAVITVL SLVLFRSPLV 351 SMYNNDPAVL SIAATVLLFA GLFQPADFTQCIASYALRGY KVTKVPMFIH 401 AAAFWGCGLL PGYLLAYRFDMGIYGFWTAL IASLTIAAIA LVWCLELCSR 451 EMVRSHKAV* m607/a607 98.9% identityin 459 aa overlap        10        20        30        40        50        60 m607.pepMLLDLNRFSFPVFLKEVRLLTTLALPMLLAQVAQVGIGFVDTVMAGGAGKEDLAAVALGS|||||||||| ||||||||||:|||||||||||||||||||||||||||||||||||||| a607MLLDLNRFSFSVFLKEVRLLTALALPMLLAQVAQVGIGFVDTVMAGGAGKEDLAAVALGS        10        20        30        40        50        60        70        80        90       100       110       120 m607.pepSAFATVYITFMGIMAALNPMIAQLYGAGKTDEVGETGRQGIWFGLFLGVFGMVLMWAAIT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a607SAFATVYITFMGIMAALNPMIAQLYGAGKTDEVGETGRQGIWFGLFLGVFGMVLMWAAIT        70        80        90       100       110       120       130       140       150       160       170       180 m607.pepPFRNWLTLSDYVEGTMAQYMLFTSLAMPAAMVHRALHAYTSSLNRPRLIMLVSFAAFVLN|||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||| a607PFRNWLTLSDYVEGTMAQYMLFTSLAMPAAMVHRALHAYASSLNRPRLIMLVSFAAFVLN       130       140       150       160       170       180       190       200       210       220       230       240 m607.pepVPLNYIFVYGKFGMPALGGAGCGLATMAVFWFSALALWIYIAKENFFRPFGLTAKFGKPD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a607VPLNYIFVYGKFGMPALGGAGCGLATMAVFWFSALALWIYIAKENFFRPFGLTAKFGKPD       190       200       210       220       230       240       250       260       270       280       290       300 m607.pepWAVFKQIWKIGAPIGLSYFLEASAFSFIVFLIAPFGEDYVAAQQVGISLSGILYMIPQSV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a607WAVFKQIWKIGAPIGLSYFLEASAFSFIVFLIAPFGEDYVAAQQVGISLSGILYMIPQSV       250       260       270       280       290       300       310       320       330       340       350       360 m607.pepGSAGTVRIGFSLGRREFSRARYISGVSLVLGWMLAVITVLSLVLFRSPLVSMYNNDPAVL||||||||||||||||||||||||||||| |||||||||||||||||||||||||||||| a607GSAGTVRIGFSLGRREFSRARYISGVSLVSGWMLAVITVLSLVLFRSPLVSMYNNDPAVL       310       320       330       340       350       360       370       380       390       400       410       420 m607.pepSIAATVLLFAGLFQPADFTQCIASYALRGYKVTKVPMFIHAAAFWGCGLLPGYLLAYRFN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: a607SIAATVLLFAGLFQPADFTQCIASYALRGYKVTKVPMFIHAAAFWGCGLLPGYLLAYRFD       370       380       390       400       410       420       430       440       450       460 m607.pepMGIYGFWTALIASLTIAAIALVWCLELCSREMVRSHKAVX|||||||||||||||||||||||||||||||||||||||| a607MGIYGFWTALIASLTIAAIALVWCLELCSREMVRSHKAVX       430       440       450       460The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 1925>:

g608.seq 1 ATGTCCGCCC TCCTCCCCAT CATCAACCGC CTGATTCTGC AAAGCCCGGA 51CAGCCGCTCG GAACTTACCT CCTTTGCAGG CAAAACACTG ACCCTGAACA 101 TTGCCGGGCTGAAACTGGCG GGACGCATCA CAGAAGACGG TTTGCTCTCG 151 GCGGGAAACG GCTTTGCAGACACCGAAATT ACCTTCCGCA ACAGCGCGAT 201 ACGGAAAATC CTCCAAGGCG GCGAACCCGGGGCTGGCGAC ATCAGGCTCG 251 AAGGCGACCT CATCCTCGGC ATcGCGGTAC TGTCCCTGCTCGGCAGCCTG 301 CGTTCCCGCG CATCGGacgA ATTGGCACGG ATTTTCGGCA CGCAGGCAGg351 catcggcagc CGTGCCACCG ACATCGGACA CGGCaTCaaa cAAATCGGCA 401GGAACATCGC CGAACAAATC GGCGGATTTT CCCGCGAACC CGAGTCcgCa 451 aacaccggcaacgaagccct tgccgactgc ctCGACGAAA TAAGCAGACT 501 GCGCGACGGC GTGGAACGCCTCAACGAACG CCTCGACAGG CTCGAACGCG 551 ACATTTGGAT AGACTAAThis corresponds to the amino acid sequence <SEQ ID 1926; ORF 608.ng>:

g608.pep 1 MSALLPIINR LILQSPDSRS ELTSFAGKTL TLNIAGLKLA GRITEDGLLS 51AGNGFADTEI TFRNSAIRKI LQGGEPGAGD IRLEGDLILG IAVLSLLGSL 101 RSRASDELARIFGTQAGIGS RATDIGHGIK QIGRNIAEQI GGFSREPESA 151 NTGNEALADC LDEISRLRDGVERLNERLDR LERDIWID*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1927>:

m608.seq 1 ATGTCCGCCC TCCTCCCCAT CATCAACCGC CTGATTCTGC AAAGCCCGGA 51CAGCCGCTCG GAACTTGCCG CCTTTGCAGG CAAAACACTG ACCCTGAACA 101 TTGCCGGGCTGAAACTGGCG GGACGCATCA CGGAAGACGG TTTGCTCTCG 151 GCGGGAAACG GCTTTGCAGACACCGAAATT ACCTTCCGCA ACAGCGCGGT 201 ACAGAAAATC CTCCAAGGAG GCGAACCCGGGGCGGGCGAC ATCGGGCTCG 251 AAGGCGACCT CATCCTCGGC ATCGCGGTAC TGTCCCTGCTCGGCAGCCTG 301 CGTTCCCGCG CATCGGACGA ATTGGCACGG ATTTTCGGCA CGCAGGCAGA351 CATCGGCAGC CGTGCCGCCG ACATCGGACA CGGCATCAAA CAAATCGGCA 401GGAACATCGC CGAACAAATC GGCGGATTTT CCCGCGAATC CGAGTCCGCA 451 AACATCGGCAACGAAGCCCT TGCCGACTGC CTCGACGAAA TAAGCAGACT 501 GCGCGACGGC GTGGAACGCCTCAACGAACG CCTCGACCGG CTCGAACGCG 551 ACATTTGGAT AGACTAAThis corresponds to the amino acid sequence <SEQ ID 1928; ORF 608>:

m608.pep 1 MSALLPIINR LILQSPDSRS ELAAFAGKTL TLNIAGLKLA GRITEDGLLS 51AGNGFADTEI TFRNSAVQKI LQGGEPGAGD IGLEGDLILG IAVLSLLGSL 101 RSRASDELARIFGTQADIGS RAADIGHGIK QIGRNIAEQI GGFSRESESA 151 NIGNEALADC LDEISRLRDGVERLNERLDR LERDIWID*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 608 shows 95.2% identity over a 188 aa overlap with a predicted ORF(ORF 608.ng) from N. gonorrhoeae:

m608/g608         10        20        30        40        50        60m608.pep MSALLPIINRLILQSPDSRSELAAFAGKTLTLNIAGLKLAGRITEDGLLSAGNGFADTEI||||||||||||||||||||||::|||||||||||||||||||||||||||||||||||| g608MSALLPIINRLILQSPDSRSELTSFAGKILTLNIAGLKLAGRITEDGLLSAGNGFADTEI        10        20        30        40        50        60        70        80        90       100       110       120 m608.pepTFRNSAVQKILQGGEPGAGDIGLEGDLILGIAVLSLLGSLRSRASDELARIFGTQADIGS||||||::||||||||||||| |||||||||||||||||||||||||||||||||| ||| g608TFRNSAIRKILQGGEPGAGDIRLEGDLILGIAVLSLLGSLRSRASDELARIFGTQAGIGS        70        80        90       100       110       120       130       140       150       160       170       180 m608.pepRAADIGHGIKQIGRNIAEQIGGFSRESESANIGNEALADCLDEISRLRDGVERLNERLDR||:||||||||||||||||||||||| |||| |||||||||||||||||||||||||||| g608RATDIGHGIKQIGRNIAEQIGGFSREPESANIGNEALADCLDEISRLRDGVERLNERLDR       130       140       150       160       170       180       189m608.pep LERDIWIDX ||||||||| g608 LERDIWIDXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1929>:

a608.seq 1 ATGTCCGCCC TCCTCCCCAT CATCAACCGC CTGATTCTGC AAAGCCCGGA 51CAGCCGCTCG GAACTTGCCG CCTTCGCAGG CAAAACACTG ACCCTGAACA 101 TTGCCGGGTTGAAACTGGCG GGACGCATCA CGGAAGACGG TTTGCTCTCG 151 GCGGGAAACG GCTTTGCAGACACCGAAATC ACCTTCCGCA ACAGCGCGGT 201 ACAGAAAATC CTCCAAGGCG GCGAACCCGGGGCGGGCGAC ATCGGGCTCG 251 AAGGCGACCT CATCCTCGGC ATCGCGGTAC TGTCCCTGCTCGGCAGCCTG 301 CGTTCCCGCG CATCGGACGA ATTGGCACGG ATTTTCGGCA CGCAGGCAGA351 CATCGGCAGC CGTGCCGCCG ACATCGGACA CGGCATCAAA CAAATCGGCA 401GGAACATCGC CGAACAAATC GGCAGATTTT CCCGCGAACC CGAGTCCGCA 451 AACATCGGCAACGAAGCCCT TGCCGACTGC CTCGACGAAA TAAGCAGACT 501 GCGCGACGGC GTGGAACGCCTCAACGAACG CCTCGACCGG CTCGAACGCG 551 ACATTTGGAT AGACTAAThis corresponds to the amino acid sequence <SEQ ID 1930; ORF 608.a>:

a608.pep 1 MSALLPIINR LILQSPDSRS ELAAFAGKTL TLNIAGLKLA GRITEDGLLS 51AGNGFADTEI TFRNSAVQKI LQGGEPGAGD IGLEGDLILG IAVLSLLGSL 101 RSRASDELARIFGTQADIGS RAADIGHGIK QIGRNIAEQI GRFSREPESA 151 NIGNEALADC LDEISRLRDGVERLNERLDR LERDIWID* m608/a608 98.9% identity in 188 aa overlap        10        20        30        40        50        60 m608.pepMSALLPIINRLILQSPDSRSELAAFAGKTLTLNIAGLKLAGRITEDGLLSAGNGFADTEI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a608MSALLPIINRLILQSPDSRSELAAFAGKILTLNIAGLKLAGRITEDGLLSAGNGFADTEI        10        20        30        40        50        60        70        80        90       100       110       120 m608.pepTFRNSAVQKILQGGEPGAGDIGLEGDLILGIAVLSLLGSLRSRASDELARIFGTQADIGS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a608TFRNSAVQKILQGGEPGAGDIGLEGDLILGIAVLSLLGSLRSRASDELARIFGTQADIGS        70        80        90       100       110       120       130       140       150       160       170       180 m608.pepRAADIGHGIKQIGRNIAEQIGGFSRESESANIGNEALADCLDEISRLRDGVERLNERLDR||||||||||||||||||||| |||| ||||||||||||||||||||||||||||||||| a608RAADIGHGIKQIGRNIAEQIGRFSREPESANIGNEALADCLDEISRLRDGVERLNERLDR       130       140       150       160       170       180       189m608.pep LERDIWIDX ||||||||| a608 LERDIWIDXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1931>:

g609.seq 1 ATGGTTGTGG ATAGACTCGA AATTCTCGCT CTCGACGACG AAACTCTTGA 51TGCGTTTGTC GGCAATCAGC GAAGTAGCGA CATCGCGCAC CATATCTTCC 101 ACGAATTTCGGGTTTTCGTA GGCCTTTTCG GTAACGTATT TTTCATCGGG 151 GCGTTTGAGC AGGCCGTAGAGTTGGCAGCT CGCCTGCGTT TCCACATAAT 201 CGATAACTTC CTCGATACCG ACTTCGGCATCGGAAGTCAG GCTGACGGTA 251 ACGTGCGAAC GCTGATTATG CGCGCCATAT TGGGAAATTTCTTTGGAACA 301 CGGGCAAAGC GAGGTTACGG GAATCATGAC CTTCATACTG TGGCCGTATG351 CCCCGTCTTT CATTTCACCC GTGAGGCTGA CATCATAATC CAGtaaThis corresponds to the amino acid sequence <SEQ ID 1932; ORF 609.ng>:

g609.pep 1 MVVDRLEILA LDDETLDAFV GNQRSSDIAH HIFHEFRVFV GLFGNVFFIG 51AFEQAVELAA RLRFHIIDNF LDTDFGIGSQ ADGNVRTLIM RAILGNFFGT 101 RAKRGYGNHDLHTVAVCPVF HFTREADIII Q*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1933>:

m609.seq 1 ATGGTTGTGG ATAGACTCGA AATTCTCGCT CTCGACGACG AAACTCTTGA 51TGCGTTTGTC GGCAATCAGC GAAGTAGCGA CATCGCGCAC CATATCTTCC 101 ACGAATTTCGGGTTTTCGTA GGCTTTTTCG GTAACGTATT TTTCATCGGG 151 GCGTTTGAGC AGGCCGTAGAGTTGGCAGCT CGCCTGCGCC TCCACATAAT 201 CGATGACTTC CTCGATACCG ACTTCGGCATCGGCAGTCAG GCTGACGGTA 251 ACGTGCGAAC GCTGGTTGTG CGCGCCGTAT TGGGAAATTTCTTTGGAACA 301 CGGGCAAAGC GAGGTTACGG GAATCATGAC CTTCATACTG TGGCCGTATG351 CCCCGTCTTT GATTTCGCCC GTGAGACAGA CATCATAATC CAGTAAThis corresponds to the amino acid sequence <SEQ ID 1934; ORF 609>:

m609.pep 1 MVVDRLEILA LDDETLDAFV GNQRSSDIAH HIFHEFRVFV GFFGNVFFIG 51AFEQAVELAA RLRLHIIDDF LDTDFGIGSQ ADGNVRTLVV RAVLGNFFGT 101 RAKRGYGNHDLHTVAVCPVF DFARETDIII Q* m609/g609 93.1% identity in 131 aa overlap        10        20        30        40        50        60 m609.pepMVVDRLEILALDDETLDAFVGNQRSSDIAHHIFHEFRVFVGFFGNVFFIGAFEQAVELAA|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| g609MVVDRLEILALDDETLDAFVGNQRSSDIAHHIFHEFRVFVGLFGNVFFIGAFEQAVELAA        10        20        30        40        50        60        70        80        90       100       110       120 m609.pepRLRLHIIDDFLDTDFGIGSQADGNVRTLVVRAVLGNFFGTRAKRGYGNHDLHTVAVCPVF|||:||||:|||||||||||||||||||::||:||||||||||||||||||||||||||| g609RLRFHIIDNFLDTDFGIGSQADGNVRTLIMRAILGNFFGTRAKRGYGNHDLHTVAVCPVF        70        80        90       100       110       120        130m609.pep DFARETDIIIQX |:||:|||||| g609 HFTREADIIIQX        130The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1935>:

a609.seq 1 ATGGTTGTGG ATAGACTCGA AATTCTCGCT CTCGACGACG AAACTCTTGA 51TGCGTTTGTC GGCAATCAGC GAAGTAGCGA CATCGCGCAC CATATCTTCC 101 ACGAATTTCGGGTTTTCGTA GGCTTTTTCG GTAACGTATT TTTCATCGGG 151 GCGTTTGAGC AGGCCGTAGAGTTGGCAGCT CGCCTGCGCC TCCACATAAT 201 CGATGACTTC CTCGATACCG ACTTCGGCATCGGCAGTCAG GCTGACGGTA 251 ACGTGCGAAC GCTGGTTGTG CGCGCCATAT TGGGAAATTTCTTTGGAACA 301 CGGGCAAAGC GAGGTTACGG GAATCATGAC CTTCATACTG TGGCCGTATG351 CACCGTCTTT CATTTCGCCC GTGAGGCTGA CATCATAATC CAGTAAThis corresponds to the amino acid sequence <SEQ ID 1936; ORF 609.a>:

a609.pep 1 MVVDRLEILA LDDETLDAFV GNQRSSDIAH HIFHEFRVFV GFFGNVFFIG 51AFEQAVELAA RLRLHIIDDF LDTDFGIGSQ ADGNVRTLVV RAILGNFFGT 101 RAKRGYGNHDLHTVAVCTVF HFAREADIII Q* m609/a609 96.9% identity in 131 aa overlap        10        20        30        40        50        60 m609.pepMVVDRLEILALDDETLDAFVGNQRSSDIAHHIFHEFRVFVGFFGNVFFIGAFEQAVELAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a609MVVDRLEILALDDETLDAFVGNQRSSDIAHHIFHEFRVFVGFFGNVFFIGAFEQAVELAA        10        20        30        40        50        60        70        80        90       100       110       120 m609.pepRLRLHIIDDFLDTDFGIGSQADGNVRTLVVRAVLGNFFGTRAKRGYGNHDLHTVAVCPVF||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| || a609RLRLHIIDDFLDTDFGIGSQADGNVRTLVVRAILGNFFGTRAKRGYGNHDLHTVAVCTVF        70        80        90       100       110       120        130m609.pep DFARETDIIIQX 1111:111111 a609 HFAREADIIIQX        130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1937>:

g610.seq 1 ATGATTGGAG GGCTTATGCA ATTTCCTTAC CGCAATGTTC CGGCTTCGCG 51TATGCGCCGT ATGCGCAGGG ATGATTTTTC ACGCCGCCTG ATGCGCGAGC 101 ATATGCTGACCGCCGATGAT TTGATTTATC CGGTGTTCGT ATTGGAGGGG 151 GCGGCGCGCG AGGAGGATGTGCCTTCTATG CCGGGCGTGA AGCGTCAGAG 201 TTTGGACAGG CTGCTGTTTA CGGCGGAAGAGGCGGTGAAG CTCGGTATTC 251 CGATGTTGGC ACTCTTTCCC GTGGTTACGG CAAACAAAACCGGGCGTGCG 301 CAGGAGGCGT ACAATCCCGA AGGACTCGTG CCGTCAACTG tccgagccTT351 GCGCGAGAGG TttcCcgaac tggggattat gacggatgtc gcgctcgAtc 401cttatacggt gcacGGTCAG GACGGACTGA CGGACgaaaa cggttaCGTG 451 ATGAatgATgaaaCCGTAGA AGTCTTGGTG AAACAGGCTT TATGTCATGC 501 AGAGGCGGGC ACGCAGGTCGTTGCTCCTTC CGATATGATG GACGGGCGTA 551 TCGGCGCCAT CCGCGAGGCT TTGGAGGATGCCGGACATAT CCATACGCGG 601 ATTATGGCAT ATTCCGCCAA ATATGCTTCT GCATTCTACGGCCCTTTCCG 651 TGATGCGGTA GGCAGTTCGG GCAATTTGGG AAAGGCAGAT AAAAAGACCT701 ATCAGATGGA TCCTGCAAAT ACCGATGAGG CGCTGCATGA AGTGGCGCTC 751GATATTCAGG AAGGTGCGGA TATGGTGATG GTGAAGCCCG GTTTGCCGTA 801 TTTGGACGTTGTCCGCCGCG TGAAGGACGA GTTCGGCGTA CCGACTTATG 851 CCTATCAGGT TTCGGGCGAATATGCGATGT TGCAGGCGGC GGTTGCCAAC 901 GGCTGGCTGG ACGGCGGCAA AGTGGTTTTGGAAAGCCTGC TGGCATTCAA 951 ACGTGCGGGT GCGGACGGGA TTTTGACCTA TTACGCCATTGAGGCGGCAA 1001 AGATGCTGAA GCGTTGAThis corresponds to the amino acid sequence <SEQ ID 1938; ORF 610.ng>:

g610.pep 1 MIGGLMQFPY RNVPASRMRR MRRDDFSRRL MREHMLTADD LIYPVFVLEG 51AAREEDVPSM PGVKRQSLDR LLFTAEEAVK LGIPMLALFP VVTANKTGRA 101 QEAYNPEGLVPSTVRALRER FPELGIMTDV ALDPYTVHGQ DGLTDENGYV 151 MNDETVEVLV KQALCHAEAGTQVVAPSDMM DGRIGAIREA LEDAGHIHTR 201 IMAYSAKYAS AFYGPFRDAV GSSGNLGKADKKTYQMDPAN TDEALHEVAL 251 DIQEGADMVM VKPGLPYLDV VRRVKDEFGV PTYAYQVSGEYAMLQAAVAN 301 GWLDGGKVVL ESLLAFKRAG ADGILTYYAI EAAKMLKR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1939>:

m610.seq 1 ATGATTGGAG GGCTTATGCA GTTTCCTTAC CGCAATGTTC CGGCTTCGCG 51TATGCGCCGT ATGCGCAGGG ACGATTTTTC ACGCCGCCTG ATGCGCGAAC 101 ACACGCTGACCGCCGATGAT TTGATTTATC CGGTGTTCGT ATTGGAGGGG 151 TCGGCGCGCG AGGAGGATGTGCCTTCTATG CCGGGTGTGA AGCGTCAAAG 201 TTTGGACAGG CTGCTGTTTA CGGCGGAAGAGGCGGTAAAG CTCGGTATTC 251 CGATGTTGGC ACTGTTCCCC GTGGTTACGG CAAACAAAACCGAGCGTGCG 301 CAGGAGGCGT ACAATCCCGA AGGACTCGTG CCGTCAACTG TCCGCGCCTT351 GCGCGAGAGG TTTCCCGAAC TGGGCATTAT GACGGATGTC GCGCTCGATC 401CTTATACGGT TCACGGTCAG GACGGGCTGA CGGACGAAAA CGGTTATGTG 451 ATGAACGATGAAACCGTAGA GGTTTTGGTC AAGCAGGCTT TGTGCCACGC 501 TGAAGCGGGC GCGCAGGTGGTTGCCCCTTC CGATATGATG GACGGGCGTA 551 TCGGTGCGAT TCGCGAGGCG TTGGAGGATGCCGGGCATAT CCATACGCGG 601 ATTATGGCGT ATTCCGCCAA ATATGCTTCT GCATTTTACGGCCCTTTCCG 651 TGATGCGGTA GGCAGTTCGG GCAATTTGGG CAAGGCAGAT AAAAAGACCT701 ACCAGATGGA TCCGGCAAAT ACCGATGAGG CGTTGCACGA AGTGGCGTTG 751GACATTCAGG AAGGTGCGGA TATGGTAATG GTCAAGCCCG GTTTGCCGTA 801 TTTGGACGTTGTCCGCCGCG TAAAGGACGA GTTCGGTGTG CCGACTTATG 851 CCTATCAGGT TTCGGGAGAATACGCGATGT TGCAGGCAGC GATTGCCAAC 901 GGCTGGCTGG ACGGCGGCAA AGTGGTTTTGGAAAGCCTGC TGGCATTCAA 951 ACGTGCGGGT GCGGACGGGA TTTTGACCTA TTACGCTATTGAGGCGGCAA 1001 AGATGTTGAA GCGTTGAThis corresponds to the amino acid sequence <SEQ ID 1940; ORF 610>:

m610.pep 1 MIGGLMQFPY RNVPASRMRR MRRDDFSRRL MREHTLTADD LIYPVFVLEG 51SAREEDVPSM PGVKRQSLDR LLFTAEEAVK LGIPMLALFP VVTANKTERA 101 QEAYNPEGLVPSTVRALRER FPELGIMTDV ALDPYTVHGQ DGLTDENGYV 151 MNDETVEVLV KQALCHAEAGAQVVAPSDMM DGRIGAIREA LEDAGHIHTR 201 IMAYSAKYAS AFYGPFRDAV GSSGNLGKADKKTYQMDPAN TDEALHEVAL 251 DIQEGADMVM VKPGLPYLDV VRRVKDEFGV PTYAYQVSGEYAMLQAAIAN 301 GWLDGGKVVL ESLLAFKRAG ADGILTYYAI EAAKMLKR* m610/g61098.5% identity in 338 aa overlap        10        20        30        40        50        60 m610.pepMIGGLMQFPYRNVPASRMRRMRRDDFSRRLMREHTLTADDLIYPVFVLEGSAREEDVPSM|||||||||||||||||||||||||||||||||| |||||||||||||||:||||||||| g610MIGGLMQFPYRNVPASRMRRMRRDDFSRRLMREHMLTADDLIYPVFVLEGAAREEDVPSM        10        20        30        40        50        60        70        80        90       100       110       120 m610.pepPGVKRQSLDRLLFTAEEAVKLGIPMLALFPVVTANKTERAQEAYNPEGLVPSTVRALRER||||||||||||||||||||||||||||||||||||| |||||||||||||||||||||| g610PGVKRQSLDRLLFTAEEAVKLGIPMLALFPVVTANKTGRAQEAYNPEGLVPSTVRALRER        70        80        90       100       110       120       130       140       150       160       170       180 m610.pepFPELGIMTDVALDPYTVHGQDGLTDENGYVMNDETVEVLVKQALCHAEAGAQVVAPSDMM||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| g610FPELGIMTDVALDPYTVHGQDGLTDENGYVMNDETVEVLVKQALCHAEAGTQVVAPSDMM       130       140       150       160       170       180       190       200       210       220       230       240 m610.pepDGRIGAIREALEDAGHIHTRIMAYSAKYASAFYGPFRDAVGSSGNLGKADKKTYQMDPAN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g610DGRIGAIREALEDAGHIHTRIMAYSAKYASAFYGPFRDAVGSSGNLGKADKKTYQMDPAN       190       200       210       220       230       240       250       260       270       280       290       300 m610.pepTDEALHEVALDIQEGADMVMVKPGLPYLDVVRRVKDEFGVPLYAYQVSGEYAMLQAAIAN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| g610TDEALHEVALDIQEGADMVMVKPGLPYLDVVRRVKDEFGVPLYAYQVSGEYAMLQAAVAN       250       260       270       280       290       300       310       320       330      339 m610.pepGWLDGGKVVLESLLAFKRAGADGILTYYAIEAAKMLKRX||||||||||||||||||||||||||||||||||||||| g610GWLDGGKVVLESLLAFKRAGADGILTYYAIEAAKMLKRX        310       320       330The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1941>:

a610.seq 1 ATGATTGGAG GGCTTATGCA GTTTCCTTAC CGCAATGTTT CGGCTTCGCG 51TATGCGCCGT ATGCGCAGGG ACGATTTTTC ACGCCGCCTG ATGCGCGAGC 101 ATACGCTGACTGCCGATGAT TTGATTTATC CGGTGTTCGT ATTGGAGGGG 151 TCGGCGCGCG AGGAGGATGTGCCTTCTATG CCGGGCGTGA AGCGTCAGAG 201 TTTGGACAGG CTGCTGTTTA CGGCGGAAGAGGCGGTAAAG CTCGGTATTC 251 CGATGTTGGC ACTGTTCCCC GTGGTTACGG CAAACAAAACCGAGCGTGCG 301 CAGGAGGCGT ACAATCCCGA AGGACTCGTG CCGTCAACTG TCCGCGCCTT351 GCGCGAGAGG TTTCCCGAAC TGGGCATTAT GACGGATGTC GCGCTCGATC 401CTTATACGGT GCACGGTCAG GACGGGCTGA CGGACGAAAA CGGTTATGTG 451 ATGAACGATGAAACCGTAGA GGTTTTGGTC AAGCAGGCTT TGTGTCATGC 501 AGAGGCAGGC GCACAGGTCGTTGCTCCTTC CGATATGATG GATGGGCGTA 551 TCGGTGCGAT TCGCGAGGCG TTGGAGGATGCCGGGCATAT CCATACGCGG 601 ATTATGGCGT ATTCCGCCAA ATATGCTTCT GCATTTTACGGCCCTTTCCG 651 TGATGCGGTA GGCAGTTCGG GCAATTTGGG CAAGGCAGAT AAAAAGACCT701 ACCAGATGGA TCCGGCAAAT ACCGATGAGG CGTTGCACGA AGTGGCGTTG 751GACATTCAGG AAGGTGCGGA TATGGTGATG GTCAAGCCCG GTTTGCCGTA 801 TTTGGACGTTGTCCGCCGCG TGAAGGACGA GTTCGGCGTG CCGACTTATG 851 CCTATCAGGT TTCGGGAGAATACGCGATGC TGCAGGCGGC GGTTGCCAAC 901 GGCTGGCTGG ACGGCGGCAA AGTGGTTTTGGAAAGCCTGC TGGCATTCAA 951 ACGTGCGGGT GCGGATGGGA TTTTGACCTA TTACGCCATTGAGGCGGCAA 1001 AGATGCTGAA GCGTTGAThis corresponds to the amino acid sequence <SEQ ID 1942; ORF 610.a>:

a610.pep 1 MIGGLMQFPY RNVSASRMRR MRRDDFSRRL MREHTLTADD LIYPVFVLEG 51SAREEDVPSM PGVKRQSLDR LLFTAEEAVK LGIPMLALFP VVTANKTERA 101 QEAYNPEGLVPSTVRALRER FPELGIMTDV ALDPYTVHGQ DGLTDENGYV 151 MNDETVEVLV KQALCHAEAGAQVVAPSDMM DGRIGAIREA LEDAGHIHTR 201 IMAYSAKYAS AFYGPFRDAV GSSGNLGKADKKTYQMDPAN TDEALHEVAL 251 DIQEGADMVM VKPGLPYLDV VRRVKDEFGV PTYAYQVSGEYAMLQAAVAN 301 GWLDGGKVVL ESLLAFKRAG ADGILTYYAI EAAKMLKR* m610/a61099.4% identity in 338 aa overlap        10        20        30        40        50        60 m610.pepMIGGLMQFPYRNVPASRMRRMRRDDFSRRLMREHTLTADDLIYPVFVLEGSAREEDVPSM||||||||||||| |||||||||||||||||||||||||||||||||||||||||||||| a610MIGGLMQFPYRNVSASRMRRMRRDDFSRRLMREHTLTADDLIYPVFVLEGSAREEDVPSM        10        20        30        40        50        60        70        80        90       100       110       120 m610.pepPGVKRQSLDRLLFTAEEAVKLGIPMLALFPVVTANKTERAQEAYNPEGLVPSTVRALRER|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a610PGVKRQSLDRLLFTAEEAVKLGIPMLALFPVVTANKTERAQEAYNPEGLVPSTVRALRER        70        80        90       100       110       120       130       140       150       160       170       180 m610.pepFPELGIMTDVALDPYTVHGQDGLTDENGYVMNDETVEVLVKQALCHAEAGAQVVAPSDMM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a610FPELGIMTDVALDPYTVHGQDGLTDENGYVMNDETVEVLVKQALCHAEAGAQVVAPSDMM       130       140       150       160       170       180       190       200       210       220       230       240 m610.pepDGRIGAIREALEDAGHIHTRIMAYSAKYASAFYGPFRDAVGSSGNLGKADKKTYQMDPAN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a610DGRIGAIREALEDAGHIHTRIMAYSAKYASAFYGPFRDAVGSSGNLGKADKKTYQMDPAN       190       200       210       220       230       240       250       260       270       280       290       300 m610.pepTDEALHEVALDIQEGADMVMVKPGLPYLDVVRRVKDEFGVPTYAYQVSGEYAMLQAAIAN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| a610TDEALHEVALDIQEGADMVMVKPGLPYLDVVRRVKDEFGVPTYAYQVSGEYAMLQAAVAN       250       260       270       280       290       300       310       320       330      339 m610.pepGWLDGGKVVLESLLAFKRAGADGILTYYAIEAAKMLKRX||||||||||||||||||||||||||||||||||||||| a610GWLDGGKVVLESLLAFKRAGADGILTYYAIEAAKMLKRX        310       320       330The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1943>:

g611.seq 1 ATGCCGTCTG AAAACGGGAT GGGAAAACGG CAGCTTGCGG GCTGCCGTTT 51GTTCGGGAAG TTAAGCCTTG TTTTCAGGCT GCTGCCCGGA CTCTGTCGAG 101 GCGGTGTCTGCCGGGGCAGG TGCTTCGGTT TTTTCCCGAG TCGGAGCGTG 151 CGGCGCGTTA TCTTCCGCCGCGTCCGCATT Ctcgcgcagg ttgtGGCtgt 201 tatcctTGGG CGGGCTGggt tgtttgcccgccataaTTtc cagtacctgA 251 TcgcgGTCta tggtttcCCa ttCcatcagg gctttgcacaTCGTTTCCAT 301 cttgTCGCGG TTTTcatcga ggaTTTTGTA ggcaacCTGA TACTgctcgt351 ccaaaAtccg Gcggatttcc gcgtcgAtgt cctgctgggt tTTCTCGGAA 401ATGTTTTGCG AACGGgttac gctGCGCCCC AAGAAGACTT CGCCTTCGTT 451 TTCCGCATAAACCATCACGC CCATTTTGtc gCTCAtgcCG TAGCGCGTTA 501 CCATTTCGCG TGCCATTTGGGTTGCGCGTT CAAAGTCGTT TGAThis corresponds to the amino acid sequence <SEQ ID 1944; ORF 611.ng>:

g611.pep 1 MPSENGMGKR QLAGCRLFGK LSLVFRLLPG LCRGGVCRGR CFGFFPSRSV 51RRVIFRRVRI LAQVVAVILG RAGLFARHNF QYLIAVYGFP FHQGFAHRFH 101LVAVFIEDFV GNLILLVQNP ADFRVDVLLG FLGNVLRTGY AAPQEDFAFV 151 FRINHHAHFVAHAVARYHFA CHLGCAFKVV *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1945>:

m611.seq 1 ATGCCGTCTG AAAACGGGAT GGGAAAACGG CAGCTTGCGG GCTGCCGTTT 51GTTCGGGAAG TTAAGCCTTG TTTTCAGGCT GCTGCTCGGA CTCTGTCGAA 101 GCGGTGTCTGCCGGGGCAGG TGCTTCGGTT TCTTCCCGAG TCGGAGCGTG 151 CGGCGCGTTA TCTTCCGCCGCGTCCGCATT CTCGCGCAGG TTGTGGCTGT 201 AATCTTTGGG CGGGCTGGGT TGTTTGCCCGCCATGATTTC CAGTACCTGA 251 TCGCGGTCGA TGGTTTCCCA TTCCATCAGG GCTTTGCACATCGTTTCCAT 301 CTTGTCGCGG TTTTCATCGA GGATTTTGTA GGCAACCTGA TATTGCTCGT351 CCAAAATCCG GCGGATTTCC GCGTCGATGT CCTGCTGGGT TTTCTCGGAA 401ATGTTTTGCG AACGGGTTAC GCTGCGTCCC AAGAAGACTT CGCCTTCGTT 451 TTCCGCATAAACCATCACGC CCATTTTGTC GCTCATGCCG TAGCGCGTTA 501 CCATTTCGCG CGCCATTTGGGTTGCGCGTT CAAAGTCGTT TGAThis corresponds to the amino acid sequence <SEQ ID 1946; ORF 611>:

m611.pep 1 MPSENGMGKR QLAGCRLFGK LSLVFRLLLG LCRSGVCRGR CFGFFPSRSV 51RRVIFRRVRI LAQVVAVIFG RAGLFARHDF QYLIAVDGFP FHQGFAHRFH 101LVAVFIEDFV GNLILLVQNP ADFRVDVLLG FLGNVLRTGY AASQEDFAFV 151 FRINHHAHFVAHAVARYHFA RHLGCAFKVV * m611/g611 96.1% identity in 180 aa overlap        10        20        30        40        50        60 m611.pepMPSENGMGKRQLAGCRLFGKLSLVFRLLLGLCRSGVCRGRCFGFFPSRSVRRVIFRRVRI|||||||||||||||||||||||||||| ||||:|||||||||||||||||||||||||| g611MPSENGMGKRQLAGCRLFGKLSLVFRLLPGLCRGGVCRGRCFGFFPSRSVRRVIFRRVRI        10        20        30        40        50        60        70        80        90       100       110       120 m611.pepLAQVVAVIFGRAGLFARHDFQYLIAVDGFPFHQGFAHRFHLVAVFIEDFVGNLILLVQNP||||||||:|||||||||:||||||| ||||||||||||||||||||||||||||||||| g611LAQVVAVILGRAGLFARHNFQYLIAVYGFPFHQGFAHRFHLVAVFIEDFVGNLILLVQNP        70        80        90       100       110       120       130       140       150       160       170       180 m611.pepADFRVDVLLGFLGNVLRTGYAASQEDFAFVFRINHHAHFVAHAVARYHFARHLGCAFKVV|||||||||||||||||||||| ||||||||||||||||||||||||||| ||||||||| g611ADFRVDVLLGFLGNVLRTGYAAPQEDFAFVFRINHHAHFVAHAVARYHFACHLGCAFKVV       130       140       150       160       170       180 m611.pep X| g611 XThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1947>:

a611.seq 1 ATGCCGTCTG AAAACAGGAT GGGAAAACGG CAGCTTGCGG GCTGCCGTTT 51GTTCGGGAAG TTAAGCCTTG TTTTCAGGCT GCTGCTCGGA CTCTGTCGAA 101 GCGGTGTCTGCCGGGGCAGG TGCTTCGGTT TCTTCCCGAG TCGGAGCGTG 151 CGGCGCGTTA TCTTCCGCCGCGTCCGCATT CTCGCGCAGG TTGTGGCTGT 201 AATCTTTGGG CGGGCTGGGT TGTTTGCCCGCCATGATTTC CAGTACCTGA 251 TCGCGGTCGA TGGTTTCCCA TTCCATCAGG GCTTTGCACATCGTTTCCAT 301 CTTGTCGCGG TTTTCATCGA GGATTTTGTA GGCAACCTGA TACTGCTCGT351 CCAAAATCCG GCGGATTTCC GCATCGATGT CCTGCTGGGT TTTCTCGGAA 401ATGTTTTGCG AACGGGTTAC GCTGCGTCCC AAGAAGACTT CGCCTTCGTT 451 TTCCGCATAAACCATCACGC CCATTTTGTC GCTCATGCCG TAGCGCGTTA 501 CCATTTCGCG CGCCATTTGGGTTGCGCGTT CAAAGTCGTT TGAThis corresponds to the amino acid sequence <SEQ ID 1948; ORF 611.a>:

a611.pep 1 MPSENRMGKR QLAGCRLFGK LSLVFRLLLG LCRSGVCRGR CFGFFPSRSV 51RRVIFRRVRI LAQVVAVIFG RAGLFARHDF QYLIAVDGFP FHQGFAHRFH 101LVAVFIEDFV GNLILLVQNP ADFRIDVLLG FLGNVLRTGY AASQEDFAFV 151 FRINHHAHFVAHAVARYHFA RHLGCAFKVV * m611/a611 98.9% identity in 180 aa overlap        10        20        30        40        50        60 m611.pepMPSENGMGKRQLAGCRLFGKLSLVFRLLLGLCRSGVCRGRCFGFFPSRSVRRVIFRRVRI||||| |||||||||||||||||||||||||||||||||||||||||||||||||||||| a611MPSENRMGKRQLAGCRLFGKLSLVFRLLLGLCRSGVCRGRCFGFFPSRSVRRVIFRRVRI        10        20        30        40        50        60        70        80        90       100       110       120 m611.pepLAQVVAVIFGRAGLFARHDFQYLIAVDGFPFHQGFAHRFHLVAVFIEDFVGNLILLVQNP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a611LAQVVAVIFGRAGLFARHDFQYLIAVDGFPFHQGFAHRFHLVAVFIEDFVGNLILLVQNP        70        80        90       100       110       120       130       140       150       160       170       180 m611.pepADFRVDVLLGFLGNVLRTGYAASQEDFAFVFRINHHAHFVAHAVARYHFARHLGCAFKVV||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||| a611ADFRIDVLLGFLGNVLRTGYAASQEDFAFVFRINHHAHFVAHAVARYHFARHLGCAFKVV       130       140       150       160       170       180 m611.pep X| a611 XThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1949>:

g612.seq 1 ATGGgcttcg gcggcaatat tgcAAAAAAG CTGGCcggGg taGATGAAAT 51AGCCTttgac tttgacggcA TCGTCTTTGA TTTCGGGCGT GATGATGCTG 101 TCCGGCataGCGGCGTAATC AATGCTGCTG TCGCCGGCCT GCATATAGTC 151 GGTGAAGTTT TCGCTGATAAAGCGGTAGAA AAGTGTGCCG AGAACGTATT 201 GTTTAAAGTC CCAGCCATCC ACCGCGCCGCGTACTTCGTC GGCGATTTTC 251 CAAATTTGGC GGTGCAGTTG GGCGCGTTGT TGCATTTCGGTCATCATCGA 301 AATCCATATA TAAAGTTAAA CAAATCAAAA TCGCCTGATA TTTTCAGACG351 ATTTTTTTAC GGGCATTCAA ATTAAThis corresponds to the amino acid sequence <SEQ ID 1950; ORF 612.ng>:

g612.pep 1 MGFGGNIAKK LAGVDEIAFD FDGIVFDFGR DDAVRHSGVI NAAVAGLHIV 51GEVFADKAVE KCAENVLFKV PAIHRAAYFV GDFPNLAVQL GALLHFGHHR 101 NPYIKLNKSKSPDIFRRFFY GHSN*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1951>:

m612.seq 1 ATGGGCTTCG GCGGCAATAT TGCAAAAAAG CTGGCCGGGG TAGATGAAAT 51AGCCTTTAAC TTTGACGGCA TCGTCTTTGA TTTCGGGCGT GATGATGCTG 101 TCCGGCATAGCGGCGTAATC AATACTGCTG TCGCCTGCCT GCATATAGTC 151 GGTGAAGTTT TCGCTGATAAAGCGGTAGAA AAGTGTGCCG AGAACGTATT 201 GTTTAAAGTC CCAGCCATCC ACCGCGCCGCGTACTTCGTC GGCAATTTTC 251 CAAATTTGGC GGTGCAGTTG GGCGCGTTGT TGCATTTCGGTCATCATCGA 301 AATCCATATA .AAAGTTAAA CAAATCAAAA TCGCCTGATA TTTTCAGACG351 ATTTTTTTAC GGGCATTCAA ATTAAThis corresponds to the amino acid sequence <SEQ ID 1952; ORF 612>:

m612.pep 1 MGFGGNIAKK LAGVDEIAFN FDGIVFDFGR DDAVRHSGVI NTAVACLHIV 51GEVFADKAVE KCAENVLFKV PAIHRAAYFV GNFPNLAVQL GALLHFGHHR 101 NPYXKLNKSKSPDIFRRFFY GHSN* m612/g612 96.0% identity in 124 aa overlap        10        20        30        40        50        60 m612.pepMGFGGNIAKKLAGVDEIAFNFDGIVFDFGRDDAVRHSGVINTAVACLHIVGEVFADKAVE|||||||||||||||||||:|||||||||||||||||||||:||| |||||||||||||| g612MGFGGNIAKKLAGVDEIAFDFDGIVFDFGRDDAVRHSGVINAAVAGLHIVGEVFADKAVE        10        20        30        40        50        60        70        80        90       100       110       120 m612.pepKCAENVLFKVPAIHRAAYFVGNFPNLAVQLGALLHFGHHRNPYXKLNKSKSPDIFRRFFY|||||||||||||||||||||:||||||||||||||||||||| |||||||||||||||| g612KCAENVLFKVPAIHRAAYFVGDFPNLAVQLGALLHFGHHRNPYIKLNKSKSPDIFRRFFY        70        80        90       100       110       120 m612.pepGHSNX ||||| g612 GHSNXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 1953>:

a612.seq 1 ATGGGCTTCG GCGGCAATAT TGCAAAAAAG CTGGCCGGGG TAGATGAAAT 51AGCCTTTGAC TTTGACGGCA TCGTCTTTGA TTTCGGGCGT GATGATGCTG 101 TCCGGCATAGCGGCGTAATC AATACTGCTG TCGCCTGCCT GCATATAGTC 151 GGTAAAGTTT TCGCTGATAAAGCGGTAGAA AAGTGTGCCG AGAACGTATT 201 GTTTGAAGTC CCAGCCATCC ACCGCGCCGCGTACTTCGTC GGCAATTTTC 251 CAAATTTGGC GGTGCAGTTG GGCGCGTTGT TGTATTTCGGTCATCATCGA 301 AATCCATAT. AAAAGTTAAA CAAATCAAAA TCGCCTGATA TTTTCAGACG351 ATTTTTT.AC GGGCATTCAA ATTAAThis corresponds to the amino acid sequence <SEQ ID 1954: ORF 612.a>:

a612.pep 1 MGFGGNIAKK LAGVDEIAFD FDGIVFDFGR DDAVRHSGVI NTAVACLHIV 51GKVFADKAVE KCAENVLFEV PAIHRAAYFV GNFPNLAVQL GALLYFGHHR 101 NPYXKLNKSKSPDIFRRFFX GHSN* m612/a612 96.0% identity in 124 aa overlap        10        20        30        40        50        60 m612.pepMGFGGNIAKKLAGVDEIAFNFDGIVFDFGRDDAVRHSGVINTAVACLHIVGEVFADKAVE|||||||||||||||||||:|||||||||||||||||||||||||||||||:|||||||| a612MGFGGNIAKKLAGVDEIAFDFDGIVFDFGRDDAVRHSGVINTAVACLHIVGKVFADKAVE        10        20        30        40        50        60        70        80        90       100       110       120 m612.pepKCAENVLFKVPAIHRAAYFVGNFPNLAVQLGALLHFGHHRNPYXKLNKSKSPDIFRRFFY||||||||:|||||||||||||||||||||||||:|||||||||||||||||||||||| a612KCAENVLFEVPAIHRAAYFVGNFPNLAVQLGALLYFGHHRNPYXKLNKSKSPDIFRRFFX        70        80        90       100       110       120 m612.pepGHSNX ||||| a612 GHSNXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1955>:

g613.seq 1 ATGTCGCGTT CGAGCCTGTC GAGGCGTTCG TTGAGGCGTT CCACGCCGTC 51GCGCAGTCTG CTTATTTCGT CGaggcagtc ggcaagggct tcgttgccgg 101 tgtttGcgGACTCGGGTTCG CGGGAAAATC CGCCGATTTG TTCGGCGATG 151 TTCCTGCCGA TTTgtttGAtGCCGTGTCCG ATGTCGGTGG CACGgctgcc 201 gatgcCTGCC TGCGTGCCGA AAATCCGTGCCAATTcgtCC GATGCGCGGG 251 AACGCAGGCT GCCGAGCAGG GACAGTACCG CgATGCCGAGGATGAGGTCG 301 CCTTCGAGCC TGATGTCGCC AGCCCCGGGT TCGCCGCCTT GGAGGATTTT351 CCGTATCGCG CTGTTGCGGA AGGTAATTTC GGTGTCTGCA AAGCCGTTTC 401CCGCCGAGAG CAAACCGTCT TCTGTGATGC GTCCCGCCAG TTTCAGCCCG 451 GCAATGTTCAGGGTCAGTGT TTTGCCTGCA AAGGAGGTAA GTTCCGAGCG 501 GCTGTCCGGG CTTTGCAGAATCAGGCGGTT GATGATGGGG AGGAGGGCGG 551 ACATATTTTC TGATTGGGGC GGAGAATGCCTGTTGTTGCT GTTGCCGCTT 601 ATTTTACAGG CTTAAThis corresponds to the amino acid sequence <SEQ ID 1956; ORF 613.ng>:

g613.pep 1 MSRSSLSRRS LRRSTPSRSL LISSRQSARA SLPVFADSGS RENPPICSAM 51FLPICLMPCP MSVARLPMPA CVPKIRANSS DARERRLPSR DSTAMPRMRS 101 PSSLMSPAPGSPPWRIFRIA LLRKVISVSA KPFPAESKPS SVMRPASFSP 151 AMFRVSVLPA KEVSSERLSGLCRIRRLMMG RRADIFSDWG GECLLLLLPL 201 ILQA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1957>:

m613.seq 1 ATGTCGCGTT CGAGCCGGTC GAGGCGTTCG TTGAGGCGTT CCACGCCGTC 51GCGCAGTCTG CTTATTTCGT CGAGGCAGTC GGCAAGGGCT TCGTTGCCGA 101 TGTTTGCGGACTCGGATTCG CGGGAAAATC CGCCGATTTG TTCGGCGATG 151 TTCCTGCCGA TTTGTTTGATGCCGTGTCCG ATGTCGGCGG CACGGCTGCC 201 GATGTCTGCC TGCGTGCCGA AAATCCGTGCCAATTCGTCC GATGCGCGGG 251 AACGCAGGCT GCCGAGCAGG GACAGTACCG CGATGCCGAGGATGAGGTCG 301 CCTTCGAGCC CGATGTCGCC CGCCCCGGGT TCGCCTCCTT GGAGGATTTT351 CTGTACCGCG CTGTTGCGGA AGGTAATTTC GGTGTCTGCA AAGCCGTTTC 401CCGCCGAGAG CAAACCGTCT TCCGTGATGC GTCCCGCCAG TTTCAGCCCG 451 GCAATGTTCAGGGTCAGTGT TTTGCCTGCA AAGGCGGCAA GTTCCGAGCG 501 GCTGTCCGGG CTTTGCAGAATCAGGCGGTT GATGATGGGG AGGAGGGCGG 551 ACATATTTTC TGATCGGGGC GGAGAATGCCTGTTGTTGCT GTTGCCGCTT 601 ATTTTACAGG CTTAAThis corresponds to the amino acid sequence <SEQ ID 1958; ORF 613>:

m613.pep 1 MSRSSRSRRS LRRSTPSRSL LISSRQSARA SLPMFADSDS RENPPICSAM 51FLPICLMPCP MSAARLPMSA CVPKIRANSS DARERRLPSR DSTAMPRMRS 101 PSSPMSPAPGSPPWRIFCTA LLRKVISVSA KPFPAESKPS SVMRPASFSP 151 AMFRVSVLPA KAASSERLSGLCRIRRLMMG RRADIFSDRG GECLLLLLPL 201 ILQA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m613/g613 94.6% identity in 204 aa overlap        10        20        30        40        50        60 m613.pepMSRSSRSRRSLRRSTPSRSLLISSRQSARASLPMFADSDSRENPPICSAMFLPICLMPCP||||| |||||||||||||||||||||||||||:|||| ||||||||||||||||||||| g613MSRSSLSRRSLRRSTPSRSLLISSRQSARASLPVFADSGSRENPPICSAMFLPICLMPCP        10        20        30        40        50        60        70        80        90       100       110       120 m613.pepMSAARLPMSACVPKIRANSSDARERRLPSRDSTAMPRMRSPSSPMSPAPGSPPWRIFCTA||:||||| |||||||||||||||||||||||||||||||||| |||||||||||||  | g613MSVARLPMPACVPKIRANSSDARERRLPSRDSTAMPRMRSPSSLMSPAPGSPPWRIFRIA        70        80        90       100       110       120       130       140       150       160       170       180 m613.pepLLRKVISVSAKPFPAESKPSSVMRPASFSPAMFRVSVLPAKAASSERLSGLCRIRRLMMG||||||||||||||||||||||||||||||||||||||||| :||||||||||||||||| g613LLRKVISVSAKPFPAESKPSSVMRPASFSPAMFRVSVLPAKEVSSERLSGLCRIRRLMMG       130       140       150       160       170       180       190       200 m613.pep RRADIFSDRGGECLLLLLPLILQAX|||||||| |||||||||||||||| g613 RRADIFSDWGGECLLLLLPLILQAX       190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1959>:

a613.seq 1 ATGTCGCGTT CGAGCCGGTC GAGGCGTTCG TTGAGGCGTT CCACGCCGTC 51GCGCAGTCTG CTTATTTCGT CGAGGCAGTC GGCAAGGGCT TCGTTGCCGA 101 TGTTTGCGGACTCGGGTTCG CGGGAAAATC TGCCGATTTG TTCGGCGATG 151 TTCCTGCCGA TTTGTTTGATGCCGTGTCCG ATGTCGGCGG CACGGCTGCC 201 GATGTCTGCC TGCGTGCCGA AAATCCGTGCCAATTCGTCC GATGCGCGGG 251 AACGCAGGCT GCCGAGCAGG GACAGTACCG CGATGCCGAGGATGAGGTCG 301 CCTTCGAGCC CGATGTCGCC CGCCCCGGGT TCGCCGCCTT GGAGGATTTT351 CTGTACCGCG CTGTTGCGGA AGGTGATTTC GGTGTCTGCA AAGCCGTTTC 401CCGCCGAGAG CAAACCGTCT TCCGTGATGC GTCCCGCCAG TTTCAACCCG 451 GCAATGTTCAGGGTCAGTGT TTTGCCTGCG AAGGCGGCAA GTTCCGAGCG 501 GCTGTCCGGG CTTTGCAGAATCAGGCGGTT GATGATGGGG AGGAGGGCGG 551 ACATATTTTC TGATCGGGGC GGAGAATGCCTGTTGTTGCT GTTGACGCTT 601 ATTTTACAGG CTTAAThis corresponds to the amino acid sequence <SEQ ID 1960; ORF 613.a>:

a613.pep 1 MSRSSRSRRS LRRSTPSRSL LISSRQSARA SLPMFADSGS RENLPICSAM 51FLPICLMPCP MSAARLPMSA CVPKIRANSS DARERRLPSR DSTAMPRMRS 101 PSSPMSPAPGSPPWRIFCTA LLRKVISVSA KPFPAESKPS SVMRPASFNP 151 AMFRVSVLPA KAASSERLSGLCRIRRLMMG RRADIFSDRG GECLLLLLTL 201 ILQA* m613/a613 98.0% identity in204 aa overlap        10        20        30        40        50        60 m613.pepMSRSSRSRRSLRRSTPSRSLLISSRQSARASLPMFADSDSRENPPICSAMFLPICLMPCP|||||||||||||||||||||||||||||||||||||| |||| |||||||||||||||| a613MSRSSRSRRSLRRSTPSRSLLISSRQSARASLPMFADSGSRENLPICSAMFLPICLMPCP        10        20        30        40        50        60        70        80        90       100       110       120 m613.pepMSAARLPMSACVPKIRANSSDARERRLPSRDSTAMPRMRSPSSPMSPAPGSPPWRIFCTA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a613MSAARLPMSACVPKIRANSSDARERRLPSRDSTAMPRMRSPSSPMSPAPGSPPWRIFCTA        70        80        90       100       110       120       130       140       150       160       170       180 m613.pepLLRKVISVSAKPFPAESKPSSVMRPASFSPAMFRVSVLPAKAASSERLSGLCRIRRLMMG||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||| a613LLRKVISVSAKPFPAESKPSSVMRPASFNPAMFRVSVLPAKAASSERLSGLCRIRRLMMG       130       140       150       160       170       180       190       200 m613.pep RRADIFSDRGGECLLLLLPLILQAX|||||||||||||||||| |||||| a613 RRADIFSDRGGECLLLLLTLILQAX       190       200The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1961>:

g614.seq 1 AtggcTgcgt tcAacgcttt ggacggcaaa aaagaagaca acgggcaaat 51cgaaTATTCT CAGTTCATCC GACAGGTCAA CAACGGCGAA GTATCCGGCG 101 TCAACATCGAAGGATCCGTC GTCAGCGGTT ACCTGATTAA AGGCGAGCGC 151 ACCGACAAAA GCACCTTCTTCACCAACGCG CCCTTGGATG ACAACCTGAT 201 TCAAACCCTT TTGAACAAAA ACGTCCGCGTAAAAGTAACG CCGGAAGAAA 251 AACCGAGCGC GCTGACTGCC CTGTTTTACA GCCTGCTGCCCGTCCTGCTG 301 CTGATTGGCG CATGGTTCTA CTTTATGCGT ATGCAGGCGG GCGGCGGCGG351 AAAAGGCGGC GCATTCTCCT TCGGCAAAAG CCGCGCCCGC CTGCTGGACA 401AAGATGCCAA CAAAGTTACC TTTGCCGATG TCGCCGGCTG CGACGAAGCC 451 AAAGAAGAAGTGCAGGAAAT CGTCGATTAC CTCAAAGCAC CGAACCGCta 501 tcaAAGcctc ggcggccgtgttcCGCGCGG CATCCtgCtg gcgGgcagcc 551 CGGGAaccgg taaAACACTC TTGGCGAAAGCCATTGCAGG CGAGGCCGGC 601 GTGCCGTTCT TCAGCATTTC CGGTTCCGAT TTTGTCGAAATGTTCGTCGG 651 TGTCGGTGCA AGCCGCGTCC GCGATATGTT CGAGCAGGCA AAGAAAAACG701 CCCCATGCAT TATCTTTATC GACGAGATTG ACGCGGTAGG CCGCCAACGC 751GGCGCAGgTT TGGGCGGCGG CAATGATGAG CGCGAGCAAA CATTAAACCA 801 ATTATTGGTTGAAATGGACG GTTTTGAGAG CAATCAGACT GTAATTGTGA 851 TTGCGGCAAC CAACCGCCCCGACGTACTCG ATCCTGCGCT GCAACGCCCC 901 GGCCGCTTCG ACCGCCAAGT CGTCGTCCCCCTGCCGGACA TCCGGGGGCG 951 CGAACAGatn ttGAACGTCC ATTCtaaAAA AGTGCcttTGgacgaATCTg 1001 tggaTTTATT GTCCCTCGCG CGCGGCACGC ccggtttTTc cggcgcggat1051 tTggcgaaac tggtcaacga agcccccctg tttgccggcc gccgcaacaa 1101agtgaaagtc gatcaaagcg attTGAAGAC GCCAAAGACA AAATCTATAT 1151 GGGTCCGGAACGCCGCAGTA TGGTGAThis corresponds to the amino acid sequence <SEQ ID 1962; ORF 614.ng>:

g614.pep 1 MAAFNALDGK KEDNGQIEYS QFIRQVNNGE VSGVNIEGSV VSGYLIKGER 51TDKSTFFTNA PLDDNLIQTL LNKNVRVKVT PEEKPSALTA LFYSLLPVLL 101 LIGAWFYFMRMQAGGGGKGG AFSFGKSRAR LLDKDANKVT FADVAGCDEA 151 KEEVQEIVDY LKAPNRYQSLGGRVPRGILL AGSPGTGKTL LAKAIAGEAG 201 VPFFSISGSD FVEMFVGVGA SRVRDMFEQAKKNAPCIIFI DEIDAVGRQR 251 GAGLGGGNDE REQTLNQLLV EMDGFESNQT VIVIAATNRPDVLDPALQRP 301 GRFDRQVVVP LPDIRGREQX LNVHSKKVPL DESVDLLSLA RGTPGFSGAD351 LAKLVNEAPL FAGRRNKVKV DQSDLKTPKT KSIWVRNAAV W*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1963>:

m614.seq 1 ATGGCTGCGT TCAACGCTTT AGACGGTAAA AAAGAAGACA ACGGGCAAAT 51CGAATACTCT CAGTTCATCC AACAGGTCAA CAACGGCGAA GTATCCGGCG 101 TCAACATCGAAGGATCCGTC GTCAGCGGCT ACCTGATTAA GGGCGAGCGC 151 ACCGACAAAA GCACTTTCTTCACCAACGCG CCTTTGGACG ACAACCTAAT 201 TAAAACACTG CTCGACAAAA ACGTCCGCGTAAAAGTAACG CCGGAAGAAA 251 AACCGAGCGC GCTGGCTGCC CTGTTTTACA GCCTGCTGCCCGTCCTGCTG 301 CTGATTGGCG CATGGTTCTA CTTCATGCGT ATGCAGACGG GCGGCGGCGG351 AAAAGGCGGC GCATTCTCAT TCGGTAAAAG CCGCGCCCGC CTGCTGGACA 401AAGATGCCAA CAAAGTGACC TTTGCCGATG TCGCCGGCTG CGACGAAGCC 451 AAAGAAGAAGTACAGGAAAT CGTCGATTAC CTCAAAGCGC CGAACCGCTA 501 TCAAAGCCTG GGCGGGCGCGTGCCGCGCGG CATCCTGCTG GCGGGCAGCC 551 CGGGTACGGG TAAGACGCTT TTGGCGAAAGCGATTGCAGG CGAAGCCGGC 601 GTGCCGTTCT TCAGCATTTC AGGTTCCGAC TTTGTCGAAATGTTCGTCGG 651 TGTCGGTGCG AGCCGCGTCC GCGATATGTT CGAGCAGGCG AAGAAAAACG701 CCCCCTGCAT CATCTTTATC GACGAGATTG ACGCAGTCGG CCGCCAACGC 751GGCGCAGGTT TGGGCGGCGG CAATGATGAG CGCGAGCAAA CATTAAACCA 801 ATTGTTGGTTGAAATGGACG GTTTTGAGAG CAATCAGACT GTAATTGTGA 851 TTGCGGCAAC CAACCGCCCCGACGTACTCG ATCCTGCGCT GCAACGCCCC 901 GGCCGTTTCG ACCGCCAAGT GGTTGTCCCCCTGCCGGACA TCCGAGGGCG 951 CGAACAGATT TTGAACGTCC ATTCTAAAAA AGTGCCTTTGGACGAATCTG 1001 TGGATTTATT GTCCCTCGCG CGCGGCACGC CGGGTTTTTC CGGCGCGGAT1051 TTGGCGAACT TGGTCAACGA AGCCGCCCTG TTTGCCGGCC GCCGCAATAA 1101AGTCAAAGTC GATCAGAGCG ATTTGAAGAC GCCAAAGACA AAATCTATAT 1151 GGGTCCGGAACGCCGCAGTA TGGTGAThis corresponds to the amino acid sequence <SEQ ID 1964; ORF 614>:

m614.pep 1 MAAFNALDGK KEDNGQIEYS QFIQQVNNGE VSGVNIEGSV VSGYLIKGER 51TDKSTFFTNA PLDDNLIKTL LDKNVRVKVT PEEKPSALAA LFYSLLPVLL 101 LIGAWFYFMRMQTGGGGKGG AFSFGKSRAR LLDKDANKVT FADVAGCDEA 151 KEEVQEIVDY LKAPNRYQSLGGRVPRGILL AGSPGTGKTL LAKAIAGEAG 201 VPFFSISGSD FVEMFVGVGA SRVRDMFEQAKKNAPCIIFI DEIDAVGRQR 251 GAGLGGGNDE REQTLNQLLV EMDGFESNQT VIVIAATNRPDVLDPALQRP 301 GRFDRQVVVP LPDIRGREQI LNVHSKKVPL DESVDLLSLA RGTPGFSGAD351 LANLVNEAAL FAGRRNKVKV DQSDLKTPKT KSIWVRNAAV W*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m614/g614 98.0% identity in 391 aa overlap        10        20        30        40        50        60 m614.pepMAAFNALDGKKEDNGQIEYSQFIQQVNNGEVSGVNIEGSVVSGYLIKGERTDKSTFFTNA|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| g614MAAFNALDGKKEDNGQIEYSQFIRQVNNGEVSGVNIEGSVVSGYLIKGERTDKSTFFTNA        10        20        30        40        50        60        70        80        90       100       110       120 m614.pepPLDDNLIKTLLDKNVRVKVTPEEKPSALAALFYSLLPVLLLIGAWFYFMRMQTGGGGKGG|||||||:|||:||||||||||||||||:|||||||||||||||||||||||:||||||| g614PLDDNLIQTLLNKNVRVKVTPEEKPSALTALFYSLLPVLLLIGAWFYFMRMQAGGGGKGG        70        80        90       100       110       120       130       140       150       160       170       180 m614.pepAFSFGKSRARLLDKDANKVTFADVAGCDEAKEEVQEIVDYLKAPNRYQSLGGRVPRGILL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g614AFSFGKSRARLLDKDANKVTFADVAGCDEAKEEVQEIVDYLKAPNRYQSLGGRVPRGILL       130       140       150       160       170       180       190       200       210       220       230       240 m614.pepAGSPGTGKTLLAKAIAGEAGVPFFSISGSDFVEMFVGVGASRVRDMFEQAKKNAPCIIFI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g614AGSPGIGKILLAKAIAGEAGVPFFSISGSDFVEMFVGVGASRVRDMFEQAKKNAPCIIFI       190       200       210       220       230       240       250       260       270       280       290       300 m614.pepDEIDAVGRQRGAGLGGGNDEREQTLNQLLVEMDGFESNQTVIVIAATNRPDVLDPALQRP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g614DEIDAVGRQRGAGLGGGNDEREQTLNQLLVEMDGFESNQTVIVIAATNRPDVLDPALQRP       250       260       270       280       290       300       310       320       330       340       350       360 m614.pepGRFDRQVVVPLPDIRGREQILNVHSKKVPLDESVDLLSLARGTPGFSGADLANLVNEAAL||||||||||||||||||| ||||||||||||||||||||||||||||||||:||||| | g614GRFDRQVVVPLPDIRGREQXLNVHSKKVPLDESVDLLSLARGTPGFSGADLAKLVNEAPL       310       320       330       340       350       360       370       380       390 m614.pep FAGRRNKVKVDQSDLKTPKTKSIWVRNAAVWX|||||||||||||||||||||||||||||||| g614 FAGRRNKVKVDQSDLKTPKTKSIWVRNAAVWX       370       380       390The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1965>:

a614.seq 1 ATGGCTGCGT TCAACGCTTT AGACGGTAAA AAAGAAGACA ACGGGCAAAT 51CGAATATTCT CAGTTCATCC AACAGGTCAA CAACGGCGAA GTATCCGGCG 101 TCAACATCGAAGGATCCGTC GTCAGCGGCT ACCTGATTAA GGGCGAGCGC 151 ACCGACAAAA GCACCTTCTTCACCAACGCG CCTTTGGACG ACAACCTGAT 201 TAAAACACTG CTCGACAAAA ACGTCCGTGTAAAAGTAACG CCGGAAGAAA 251 AACCGAGCGC GCTGGCTGCC CTGTTTTACA GCCTGCTGCCCGTCCTGCTG 301 CTGATTGGCG CGTGGTTCTA CTTTATGCGT ATGCAGACGG GCGGCGGCGG351 AAAAGGCGGC GCATTCTCAT TCGGCAAAAG CCGCGCCCGC CTACTGGACA 401AAGATGCCAA CAAAGTTACC TTTGCCGATG TCGCCGGCTG CGACGAAGCC 451 AAAGAAGAAGTGCAGGAAAT CGTCGATTAC CTCAAAGCGC CGAACCGCTA 501 TCAAAGCCTG GGCGGGCGCGTGCCGCGCGG CATCCTGCTG GCGGGCAGCC 551 CGGGTACGGG TAAGACGCTT TTGGCGAAAGCGATTGCAGG CGAAGCCGGC 601 GTGCCGTTCT TCAGCATTTC AGGTTCCGAC TTTGTCGAAATGTTCGTCGG 651 TGTCGGTGCA AGCCGCGTCC GCGATATGTT CGAGCAGGCG AAGAAAAACG701 CCCCCTGCAT CATCTTTATC GACGAGATTG ACGCAGTCGG CCGCCAACGC 751GGCGCAGGTT TGGGCGGCGG TAATGATGAG CGCGAGCAAA CATTAAACCA 801 ATTGTTGGTTGAAATGGACG GTTTTGAGAG CAATCAGACT GTAATTGTGA 851 TTGCGGCAAC CAACCGCCCCGACGTACTCG ATCCTGCGCT GCAACGCCCC 901 GGCCGTTTCG ACCGCCAAGT GGTTGTCCCCCTGCCGGACA TCCGGGGGCG 951 CGAACAGATT TTGAACGTCC ACTCTAAAAA AGTGCCTTTGGACAAATCTG 1001 TGGATTTATT GTCCCTCGCG CGCGGCACGC CGGGTTTTTC CGGCGCGGAT1051 TTGGCGAACT TGGTCAACGA AGCCGCCCTG TTTGCCGGCC GCCGCAATAA 1101AGTCAAAGTC GATCAGAGCG ATTTGAAGAC GCCAAAGACA AAATCTATAT 1151 GGGTCCGGAACGCCGCAGTA TGGTGAThis corresponds to the amino acid sequence <SEQ ID 1966; ORF 614.a>:

a614.pep 1 MAAFNALDGK KEDNGQIEYS QFIQQVNNGE VSGVNIEGSV VSGYLIKGER 51TDKSTFFTNA PLDDNLIKTL LDKNVRVKVT PEEKPSALAA LFYSLLPVLL 101 LIGAWFYFMRMQTGGGGKGG AFSFGKSRAR LLDKDANKVT FADVAGCDEA 151 KEEVQEIVDY LKAPNRYQSLGGRVPRGILL AGSPGTGKTL LAKAIAGEAG 201 VPFFSISGSD FVEMFVGVGA SRVRDMFEQAKKNAPCIIFI DEIDAVGRQR 251 GAGLGGGNDE REQTLNQLLV EMDGFESNQT VIVIAATNRPDVLDPALQRP 301 GRFDRQVVVP LPDIRGREQI LNVHSKKVPL DKSVDLLSLA RGTPGFSGAD351 LANLVNEAAL FAGRRNKVKV DQSDLKTPKT KSIWVRNAAV W* m614/a614 99.7%identity in 391 aa overlap        10        20        30        40        50        60 m614.pepMAAFNALDGKKEDNGQIEYSQFIQQVNNGEVSGVNIEGSVVSGYLIKGERTDKSTFFTNA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a614MAAFNALDGKKEDNGQIEYSQFIQQVNNGEVSGVNIEGSVVSGYLIKGERTDKSTFFTNA        10        20        30        40        50        60        70        80        90       100       110       120 m614.pepPLDDNLIKTLLDKNVRVKVTPEEKPSALAALFYSLLPVLLLIGAWFYFMRMQTGGGGKGG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a614PLDDNLIKTLLDKNVRVKVTPEEKPSALAALFYSLLPVLLLIGAWFYFMRMQTGGGGKGG        70        80        90       100       110       120       130       140       150       160       170       180 m614.pepAFSFGKSRARLLDKDANKVTFADVAGCDEAKEEVQEIVDYLKAPNRYQSLGGRVPRGILL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a614AFSFGKSRARLLDKDANKVTFADVAGCDEAKEEVQEIVDYLKAPNRYQSLGGRVPRGILL       130       140       150       160       170       180       190       200       210       220       230       240 m614.pepAGSPGTGKTLLAKAIAGEAGVPFFSISGSDFVEMFVGVGASRVRDMFEQAKKNAPCIIFI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a614AGSPGIGKILLAKAIAGEAGVPFFSISGSDFVEMFVGVGASRVRDMFEQAKKNAPCIIFI       190       200       210       220       230       240       250       260       270       280       290       300 m614.pepDEIDAVGRQRGAGLGGGNDEREQTLNQLLVEMDGFESNQTVIVIAATNRPDVLDPALQRP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a614DEIDAVGRQRGAGLGGGNDEREQTLNQLLVEMDGFESNQTVIVIAATNRPDVLDPALQRP       250       260       270       280       290       300       310       320       330       340       350       360 m614.pepGRFDRQVVVPLPDIRGREQILNVHSKKVPLDESVDLLSLARGTPGFSGADLANLVNEAAL|||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||| a614GRFDRQVVVPLPDIRGREQILNVHSKKVPLDKSVDLLSLARGTPGFSGADLANLVNEAAL       310       320       330       340       350       360       370       380       390 m614.pep FAGRRNKVKVDQSDLKTPKTKSIWVRNAAVWX|||||||||||||||||||||||||||||||| a614 FAGRRNKVKVDQSDLKTPKTKSIWVRNAAVWX       370       380       390The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1967>:

g615.seq 1 ATGTGGAAAC GGCGGCGGCG CGGTGtcggC AGCTTtgaag agcagcGaAT 51agatgCCGCC GGCAAACCAC AATGCGGAAa gcaggCtgaa gcGGTTgcgC 101 GGCagcTTcatGCCGCCTCC TcGTCCaGCC ACGtttGgca gattttggac 151 aggcgcAGga ATTTGCcgCcgcgtgcggCA agtatgtcgc gcCAttgtgc 201 cacttcttcg gcggacggTG cttcgtcgaTgctgCATTCG TACagcagga 251 aatcgagggt ttcttcgatg acggGgatgg AttccgTTTGGataAgCTgc 301 ttgagttcgt tcatgactGt TCgGATAcgg aaatcgggaa aatgccgtct351 gAaagggctt CAGACGGCat tggATTATTT GCTGTGCAGG AAgcgcgttg 401cctcttccca tttgcCGGAA AtgATGTCGg gtacggcctg cAGGGATttg 451 gCGACGGcatcgtcgatttg ccgGcggtgc ttCcgcgctc ggtttGTTca 501 agacgtagcc gaCGACGaggttgcggtcGC CGGGGtggcC GATGCCGAGG 551 CGCAGGCGGt aatagtctgC CGTGCCGAGTTTTGCctgAA TGTCTTTCAA 601 GCCGTTGTGT CcgcCGttgc cgcCGCCGAG TTTGAATTTgATCCGTCCGC 651 AAGGGATGTC GAGTTCGTCG TGGACGACGA GGATTTCTTC GGGTTTGATT701 TTGTAGAACT GTGCAAGCGC GGCAACCGCC TGTCCGGAAC GGTTCATGAA 751CGTGGCCGGT TTGAGCAGCC AAACATCGCC GTCGGGCAGG GCGGCGCGGG 801 CAACTTCGCCGAAGAATTTT TTTTCTTCTT TAAACGAAGC CTTCCATTTC 851 CACGCCAGTT CGTCGAGGAACCAAAAGCCC GCATTGTGGC GGGTCTGTTC 901 GTATTCTTTG CCCGGGTTGC CCAAGCCGACAACCATTTTG ATTGTGttcg 951 acatgataTT TtccgtgTTT CTgTCGaatg cggtCtgaAGGCTTCAGacg 1001 gcatggTtaT TCTTCTTgaT TTtgaACgcg tgtgcggCGC GCTTCTTTGG1051 GGTCGATCAA CAGCGGGCGG TACACTTCGA TGCGGTCGCC GTCGCGCAGC 1101GGCGTGTCGT CTTTGAThis corresponds to the amino acid sequence <SEQ ID 1968: ORF 615.ng>:

g615.pep 1 MWKRRRRGVG SFEEQRIDAA GKPQCGKQAE AVARQLHAAS SSSHVWQILD 51RRRNLPPRAA SMSRHCATSS ADGASSMLHS YSRKSRVSSM TGMDSVWISC 101 LSSFMTVRIRKSGKCRLKGL QTALDYLLCR KRVASSHLPE MMSGTACRDL 151 ATASSICRRC FRARFVQDVADDEVAVAGVA DAEAQAVIVC RAEFCLNVFQ 201 AVVSAVAAAE FEFDPSARDV EFVVDDEDFFGFDFVELCKR GNRLSGTVHE 251 RGRFEQPNIA VGQGGAGNFA EEFFFFFKRS LPFPRQFVEEPKARIVAGLF 301 VFFARVAQAD NHFDCVRHDI FRVSVECGLK ASDGMVILLD FERVCGALLW351 GRSTAGGTLR CGRRRAAACR L*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1969>:

m615.seq Length: 1116 1 ATGCGGAAAA GGCGGTGGCG CGGTTTCGGC AGCTTTGAAAAGCAGTGAGT 51 AAATGCTGCC TGCAAACCAC AATGCCGAGA GCAGGATAAA GCGGTTGCGT 101GGCAGATTCA TGCTTGTTCC TCTTCAAGCC ATGTCTGGCA TAGTTTGGAT 151 AGGCGCAGGAATTTTCCGCC GCGTGCGGCC AGCATATCGC GCCAAACGGC 201 AATTTCTTCG GCGGAGGGGGCATCGTCTAT GCTGCATTCG TAGAGCAGGA 251 AATCGAGGGT TTCTTCGATG ACGGGGATGGATTCGGTTTG GATAAGCTGC 301 TTGAGTTCGG TCATGACTGT TCGGATATGG AAATCGGGAACATGCCGTCT 351 GAAAGGGCTT CAGACGGCAT CGGGTCATTT GCTGTGCAGG AAGCGGGTTG401 CTTCTTCCCA TTTGCCGGCA AGGATGTCGG GTATGGCTTG CAGGGATTTG 451GCGACGGCAT CGTCAATCTG TCGGCGGTGT .TCCGTACTG GGTTTGTTCA 501 GGACATAGCCGACGACGAGG TTGCGGTCGC CCGGGTGGCC GATGCCGAGG 551 CGCAGGCGGT AATAGTCTGCCGTGCCGAGT TTTGCCTGAA TGTCTTTCAA 601 GCCGTTGTGT CCGCCGTTGC CGCCGCCGAGTTTGAATTTG ATCCGTCCGC 651 AGGGAATGTC GAGTTCGTCG TGGACGACGA GGATTTCTTCGGGTTTGATT 701 TTGTAGAACT GTGCAAGCGC GGCAACTGCC TGTCCGGAAC GGTTCATGAA751 CGTGGCAGGT TTGAGCAGCC AAACGTCGCC GTCGGGCAGG GCGGCACGGG 801CGACTTCGCC GAAGAATTTT TTTTCTTCTT TAAATGAAGC CTTCCATTTC 851 CACGCCAGTTCGTCGAGGAA CCAAAAACCC GCATTGTGGC GTGTCTGTTC 901 GTATTCTTTG CCCGGGTTGCCCAAGCCGAC AACCATTTTG ATTGTGTTTG 951 ACATGATATT TTCCGTGTTT CTGTCGAATGCTGTCTGAAG GCTTCAGACG 1001 GCATGGTTAT TCTTCTTGAT TTTGAACGCG TTTGCGGCGCGCTTCTTTGG 1051 GGTCGATCAA CAGCGGGCGG TACACTTCGA TGCGGTCGCC GTCGCGCAGC1101 GGCGTGTCGT CTTTGAThis corresponds to the amino acid sequence <SEQ ID 1970; ORF 615>:

m615.pep Length: 372 1 MRKRRWRGFG SFEKQXVNAA CKPQCREQDK AVAWQIHACSSSSHVWHSLD 51 RRRNFPPRAA SISRQTAISS AEGASSMLHS XSRKSRVSSM TGMDSVWISC 101LSSVMTVRIW KSGTCRLKGL QTASGHLLCR KRVASSHLPA RMSGMACRDL 151 ATASSICRRCXRTGFVQDIA DDEVAVARVA DAEAQAVIVC RAEFCLNVFQ 201 AVVSAVAAAE FEFDPSAGNVEFVVDDEDFF GFDFVELCKR GNCLSGTVHE 251 RGRFEQPNVA VGQGGTGDFA EEFFFFFKXSLPFPRQFVEE PKTRIVACLF 301 VFFARVAQAD NHFDCVXHDI FRVSVECCLK ASDGMVILLDFERVCGALLW 351 GRSTAGGTLR CGRRRAAACR L*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m615/g615 86.8% identity in 371 aa overlap        10        20        30        40        50        60 m615.pepMRKRRWRGFGSFEKQXVNAACKPQCREQDKAVAWQIHACSSSSHVWHSLDRRRNFPPRAA| ||| || ||||:| ::|| |||| :| :||| |:|| |||||||: ||||||:||||| g615MWKRRRRGVGSFEEQRIDAAGKPQCGKQAEAVARQLHAASSSSHVWQILDRRRNLPPRAA        10        20        30        40        50        60        70        80        90       100       110       120 m615.pepSISRQTAISSAEGASSMLHSXSRKSRVSSMTGMDSVWISCLSSVMTVRIWKSGTCRLKGL |:||:| |||:|||||||| |||||||||||||||||||||| ||||| ||| |||||| g615SMSRHCATSSADGASSMLHSYSRKSRVSSMTGMDSVWISCLSSFMTVRIRKSGKCRLKGL        70        80        90       100       110       120       130       140       150       160       170       180 m615.pepQTASGHLLCRKRVASSHLPARMSGMACRDLATASSICRRCXRTGFVQDIADDEVAVARVA||| :|||||||||||||  ||| ||||||||||||||| |: ||||:|||||||| || g615QTALDYLLCRKRVASSHLPEMMSGTACRDLATASSICRRCFRARFVQDVADDEVAVAGVA       130       140       150       160       170       180       190       200       210       220       230       240 m615.pepDAEAQAVIVCRAEFCLNVFQAVVSAVAAAEFEFDPSAGNVEFVVDDEDFFGFDFVELCKR||||||||||||||||||||||||||||||||||||| :||||||||||||||||||||| g615DAEAQAVIVCRAEFCLNVFQAVVSAVAAAEFEFDPSARDVEFVVDDEDFFGFDFVELCKR       190       200       210       220       230       240       250       260       270       280       290       300 m615.pepGNCLSGTVHERGRFEQPNVAVGQGGTGDFAEEFFFFFKXSLPFPRQFVEEPKTRIVACLF|| |||||||||||||||:||||||:|:|||||||||| |||||||||||||:|||| || g615GNRLSGTVHERGRFEQPNIAVGQGGAGNFAEEFFFFFKRSLPFPRQFVEEPKARIVAGLF       250       260       270       280       290       300       310       320       330       340       350       360 m615.pepVFFARVAQADNHFDCVXHDIFRVSVECCLKASDGMVILLDFERVCGALLWGRSTAGGTLR|||||||||||||||| |||||||||| |||||||||||||||||||||||||||||||| g615VFFARVAQADNHFDCVRHDIFRVSVECGLKASDGMVILLDFERVCGALLWGRSTAGGTLR       310       320       330       340       350       360        370m615.pep CGRRRAAACRLX |||||||||||| g615 CGRRRAAACRLX        370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1971>:

a615.seq 1 ATGCGGAAAC GGCGGCGGCG CGGTGTCGGC AGCTTTGAAG AGCAGCGAAT 51AGATGCCGCC GGCAAACCAC AATGCGGAAA GCAGGCTGAA GCGGTTGCGC 101 GGCAGCTTCATGCCGCCTCC TCGTCCAGCC ACGTTTGGCA GATTTTGGAC 151 AGGCGCAGGA ATTTGCCGCCGCGTGCGGCA AGTATGTCGC GCCATTGTGC 201 CACTTCTTCG GCGGATGGTG CGTCGTCGATGCTGCATTCG TACAGCAGGA 251 AATCGAGGGT TTCTTCGATG ACGGGGATGG ATTCGGTTTGGATAAGCTGC 301 TTGAGTTCGG TCATGACTGT TCGGATATGG AAATCGGGAA CATGCCGTCT351 GAAAGGGCTT CAGACGGCAT CGGGTCATTT GCTGTGCAGG AAGCGGGTTG 401CCTCTTCACA TTTGCCGGCA AGGATGTCGG GTATGGCTTG CAGGGATTTG 451 GCGACGGCATCGTCAATCTG TCGGCGGTG. TTCCGTACTG GGTTTGTTCA 501 GGACATAGCC GACGACGAGGTTGCGGTCGC CCGGGTGGCC GATGCCGAGG 551 CGCAGGCGGT AATAGTCTGC CGTGCCGAGTTTTGCCTGAA TGTCTTTCAA 601 GCCGTTGTGT CCACCGTTGC CGCCGCCGAG TTTGAATTTGATCCGTCCGC 651 AGGGAATGTC GAGTTCGTCG TGGACGACGA GGATTTCTTC GGGTTTGATT701 TTATAAAACT GCGCAAGGGC GGCAACTGCC TGTCCGGAAC GGTTCATGAA 751CGTGGTCGGC TTGAGCAGCC AGACATCGCC GTCGGGCAGG GTAGCACGGG 801 CGACTTCGCCGAAGAATTTT TTTTCTTCTT TAAATGAAGC CTTCCATTTC 851 CACGCCAGTT CGTCGAGGAACCAAAAACCC GCATTGTGGC GTGTCTGTTC 901 GTATTCTTTG CCCGGGTTGC CCAAGCCGACAACCATTTTG ATTGTGTTTG 951 ACATGATATT TTCCGTGTTT CTGCCGAATG CCGTCTGAAGGCTTCAGACG 1001 GCATGGTTAT TCTTCTTGAT TTTGAACGCG TTTGCGGCGC GCTTCTTTGG1051 GGTCGATCAA CAGCGGGCGG TACACTTCGA TGCGGTCGCC GTCGCGCAGC 1101GGCGTGTCGT CTTTGAThis corresponds to the amino acid sequence <SEQ ID 1972; ORF 615.a>:

a615.pep 1 MRKRRRRGVG SFEEQRIDAA GKPQCGKQAE AVARQLHAAS SSSHVWQILD 51RRRNLPPRAA SMSRHCATSS ADGASSMLHS YSRKSRVSSM TGMDSVWISC 101 LSSVMTVRIWKSGTCRLKGL QTASGHLLCR KRVASSHLPA RMSGMACRDL 151 ATASSICRRX FRTGFVQDIADDEVAVARVA DAEAQAVIVC RAEFCLNVFQ 201 AVVSTVAAAE FEFDPSAGNV EFVVDDEDFFGFDFIKLRKG GNCLSGTVHE 251 RGRLEQPDIA VGQGSTGDFA EEFFFFFK*S LPFPRQFVEEPKTRIVACLF 301 VFFARVAQAD NHFDCV*HDI FRVSAECRLK ASDGMVILLD FERVCGALLW351 GRSTAGGTLR CGRRRAAACR L* m615/a615 90.3% identity in 371 aa overlap        10        20        30        40        50        60 m615.pepMRKRRWRGFGSFEKQXVNAACKPQCREQDKAVAWQIHACSSSSHVWHSLDRRRNFPPRAA||||| || ||||:| ::|| |||| :| :||| |:|| |||||||: ||||||:||||| a615MRKRRRRGVGSFEEQRIDAAGKPQCGKQAEAVARQLHAASSSSHVWQILDRRRNLPPRAA        10        20        30        40        50        60        70        80        90       100       110       120 m615.pepSISRQTAISSAEGASSMLHSXSRKSRVSSMTGMDSVWISCLSSVMTVRIWKSGTCRLKGL |:||:| |||:|||||||| ||||||||||||||||||||||||||||||||||||||| a615SMSRHCATSSADGASSMLHSYSRKSRVSSMTGMDSVWISCLSSVMTVRIWKSGTCRLKGL        70        80        90       100       110       120       130       140       150       160       170       180 m615.pepQTASGHLLCRKRVASSHLPARMSGMACRDLATASSICRRCXRTGFVQDIADDEVAVARVA|||||||||||||||||||||||||||||||||||||||  ||||||||||||||||||| a615QTASGHLLCRKRVASSHLPARMSGMACRDLATASSICRRXFRTGFVQDIADDEVAVARVA       130       140       150       160       170       180       190       200       210       220       230       240 m615.pepDAEAQAVIVCRAEFCLNVFQAVVSAVAAAEFEFDPSAGNVEFVVDDEDFFGFDFVELCKR||||||||||||||||||||||||:|||||||||||||||||||||||||||||::| | a615DAEAQAVIVCRAEFCLNVFQAVVSTVAAAEFEFDPSAGNVEFVVDDEDFFGFDFIKLRKG       190       200       210       220       230       240       250       260       270       280       290       300 m615.pepGNCLSGTVHERGRFEQPNVAVGQGGTGDFAEEFFFFFKXSLPFPRQFVEEPKTRIVACLF|||||||||||||:|||::|||||:||||||||||||||||||||||||||||||||||| a615GNCLSGTVHERGRLEQPDIAVGQGSTGDFAEEFFFFFKXSLPFPRQFVEEPKTRIVACLF       250       260       270       280       290       300       310       320       330       340       350       360 m615.pepVFFARVAQADNHFDCVXHDIFRVSVECCLKASDGMVILLDFERVCGALLWGRSTAGGTLR||||||||||||||||||||||||:|| |||||||||||||||||||||||||||||||| a615VFFARVAQADNHFDCVXHDIFRVSAECRLKASDGMVILLDFERVCGALLWGRSTAGGTLR       310       320       330       340       350       360        370m615.pep CGRRRAAACRLX |||||||||||| a615 CGRRRAAACRLX        370The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1973>:

g616.seq 1 atgtcgaaCA CAATCAAAAT GGTTGTCGGC TTGGGCAACC CGGGCAAAGA 51ATACGAACAG ACCCGCCACA ATGCGGGCTT TTGGTTCCTC GACGAACTGG 101 CGTGGAAATGGAAGGCTTCG TTTAAAGAAG AAAAAAAATT CTTCGGCGAA 151 GTTGCCCGCG CCGCCCTGCCCGACGGCGAT GTTTGGCTGC TCAAACCGGC 201 CACGTTCATG AACCGTTCCG GACAGGCGGTTGCCGCGCTT GCACAGTTCT 251 ACAAAATCAA ACCCGAAGAA ATCCTCGTCG TCCACGACGAACTCGACATC 301 CCTTGCGGAC GGATcAAATT CAAACTCGGC GgcggcaaCG gcgGACACAA351 CGGCTTGAAA GACATTcagG CAAAACTCGG CACGGcagac tattaCCGCC 401TGCGCCTCGG CATCGgccaC CCCGGCgacc gcaacctCGT CGtcggctac 451 gtcttgAACaaaccgagcgc gGaagcaccg Ccggcaaatc gacgatgCCG 501 TCGccaaATC CCTgcaggccgtaccCGACA TcaTTTCCGg caaatgggaa 551 gaggcaacgc gcTTCCTGCA CAGCAAATAATccaatGCCG TCTGaagccc 601 ttTcagacgg cattttcccg atttccgTAT CcGAaCagtcatgaacgaac 651 tcaagcAGcT tatCCAAAcg gaaTccatcC ccgtcatcga agaaaccctc701 gatttcctgc tGTACGAATG cagcAtcgac gaagCAccgt ccgccgaaga 751agtggcacaa TGgcgcgaca tactTGccgc acgcgGcgGC AAATtcCTgc 801 gcctgtccaaaatctgcCaa aCGTGGCtGG ACgAGGAGGC GGCatgAAgc 851 tGCCGcgcAA CCgcttcaGcctgctTTCCG CATTGTGGTT TGCCGGCGGc 901 atctATtCgc tgctcttcaA AGCTGccgaCACCGCGCCGC CGCCGTTTCC 951 ACATTtcgaC AAAGCAGCAC ACCTTGCCCT GTTTTTCGCACAaatCTTgt 1001 tTctGGCCAA AGCATTCAAA ACCGGAAAAC TTCCCATCCC CTACCGCAGC1051 CTGATTGCGT TCGCCTTCTG TTTTGCCGTC GGCAGCGAAT GCGCGCAGGC 1101ATGGTTTACC GCAACGCGAA CCGGCAGTTT GGGCGATGTC CTTGCCgACC 1151 TGACGGGCGCAGCCCTTGCC CTCTTTGCCG CGCGTTCTGC CTGCCGcccg 1201 gactaaThis corresponds to the amino acid sequence <SEQ ID 1974: ORF 616.ng>:

g616.pep 1 MSNTIKMVVG LGNPGKEYEQ TRHNAGFWFL DELAWKWKAS FKEEKKFFGE 51VARAALPDGD VWLLKPATFM NRSGQAVAAL AQFYKIKPEE ILVVHDELDI 101 PCGRIKFKLGGGNGGHNGLK DIQAKLGTAD YYRLRLGIGH PGDRNLVVGY 151 VLNKPSAEAP PANRRCRRQIPAGRTRHHFR QMGRGNALPA QQIIQCRLKP 201 FQTAFSRFPY PNSHERTQAA YPNGIHPRHRRNPRFPAVRM QHRRSTVRRR 251 SGTMARHTCR TRRQIPAPVQ NLPNVAGRGGGMKLPRNRFS LLSALWFAGG 301 IYSLLFKAAD TAPPPFPHFD KAAHLALFFA QILFLAKAFKTGKLPIPYRS 351 LIAFAFCFAV GSECAQAWFT ATRTGSLGDV LADLTGAALA LFAARSACRP401 D*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1975>:

m616.seq 1 ATGTCAAACA CAATCAAAAT GGTTGTCGGC TTGGGCAACC CGGGCAAAGA 51ATACGAACAG ACACGCCACA ATGCGGGTTT TTGGTTCCTC GACGAACTGG 101 CGTGGAAATGGAAGGCTTCA TTTAAAGAAG AAAAAAAATT CTTCGGCGAA 151 GTCGCCCGTG CCGCCCTGCCCGACGGCGAC GTTTGGCTGC TCAAACCTGC 201 CACGTTCATG AACCGTTCCG GACAGGCAGTTGCCGCGCTT GCACAGTTCT 251 ACAAAATCAA ACCCGAAGAA ATCCTCGTCG TCCACGACGAACTCGACATT 301 CCCTGCGGAC GGATCAAATT CAAACTCGGC GGCGGCAACG GCGGACACAA351 CGGCTTGAAA GACATTCAGG CAAAACTCGG CACGGCAGAC TATTACCGCC 401TGCGCCTCGG CATCGGCCAC CCGGGCGACC GCAACCTCGT CGTCGGCTAT 451 GTCCTGAACAAACCCAGTAC GGAACA.CCG CCGACAGATT GACGATGCCG 501 TCGCCAAATC CCTGCAAGCCATACCCGACA TCCTTGCCGG CAAATGGGAA 551 GAAGCAACCC GCTTCCTGCA CAGCAAATGACCCGATGCCG TCTGAAGCCC 601 TTTCAGACGG CATGTTCCCG ATTTCCATAT CCGAACAGTCATGACCGAAC 651 TCAAGCAGCT TATCCAAACC GAATCCATCC CCGTCATCGA AGAAACCCTC701 GATTTCCTGC TCTACGAATG CAGCATAGAC GATGCCCCCT CCGCCGAAGA 751AATTGCCGTT TGGCGCGATA TGCTGGCCGC ACGCGGCGGA AAATTCCTGC 801 GCCTATCCAAACTATGCCAG ACATGGCTTG AAGAGGAACA AGCATGAATC 851 TGCCACGCAA CCGCTTTATCCTGCTCTCGG CATTGTGGTT TGCAGGCAGC 901 ATTTACTCAC TGCTTTTCAA AGCTGCCGAAACCGCGCCAC CGCCTTTTCC 951 GCATTTTGAC AAAGTGGCGC ACCTCGCCCT GTTTTTCGCACAAATCTGGC 1001 TTCTGACCAA AGCATTCAGA ACCGACAACC GCCCCATCCC CTATCGCAGC1051 CTGATGGTCT TTGCCCTCTG TTTCGCCCTC TTCAGCGAAT GCGCGCAGGC 1101ATGGTTTACC GCAACGAGAA CCGGCAGTTT GGGCGATGTC CTTGCCGACC 1151 TGACGGGCGCAGCCCTTGCC CTCTTTACCG CGCGAGCTGC CTGCCGCCCG 1201 GACTAAThis corresponds to the amino acid sequence <SEQ ID 1976: ORF 616>:

m616.pep 1 MSNTIKMVVG LGNPGKEYEQ TRHNAGFWFL DELAWKWKAS FKEEKKFFGE 51VARAALPDGD VWLLKPATFM NRSGQAVAAL AQFYKIKPEE ILVVHDELDI 101 PCGRIKFKLGGGNGGHNGLK DIQAKLGTAD YYRLRLGIGH PGDRNLVVGY 151 VLNKPSTEXP PTDXRCRRQIPASHTRHPCR QMGRSNPLPA QQMTRCRLKP 201 FQTACSRFPY PNSHDRTQAA YPNRIHPRHRRNPRFPALRM QHRRCPLRRR 251 NCRLARYAGR TRRKIPAPIQ TMPDMAXRGTSMNLPRNRFI LLSALWFAGS 301 IYSLLFKAAE TAPPPFPHFD KVAHLALFFA QIWLLTKAFRTDNRPIPYRS 351 LMVFALCFAL FSECAQAWFT ATRTGSLGDV LADLTGAALA LFTARAACRP401 D* m616/g616 86.0% identity in 401 aa overlap        10        20        30        40        50        60 m616.pepMSNTIKMVVGLGNPGKEYEQTRHNAGFWFLDELAWKWKASFKEEKKFFGEVARAALPDGD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g616MSNTIKMVVGLGNPGKEYEQTRHNAGFWFLDELAWKWKASFKEEKKFFGEVARAALPDGD        10        20        30        40        50        60        70        80        90       100       110       120 m616.pepVWLLKPATFMNRSGQAVAALAQFYKIKPEEILVVHDELDIPCGRIKFKLGGGNGGHNGLK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g616VWLLKPATFMNRSGQAVAALAQFYKIKPEEILVVHDELDIPCGRIKFKLGGGNGGHNGLK        70        80        90       100       110       120       130       140       150       160       170       180 m616.pepDIQAKLGTADYYRLRLGIGHPGDRNLVVGYVLNKPSTEXPPTDXRCRRQIPASHTRHPCR||||||||||||||||||||||||||||||||||||:| ||:: ||||||||::|||  | g616DIQAKLGTADYYRLRLGIGHPGDRNLVVGYVLNKPSAEAPPANRRCRRQIPAGRTRHHFR       130       140       150       160       170       180       190       200       210       220       230       240 m616.pepQMGRSNPLPAQQMTRCRLKPFQTACSRFPYPNSHDRTQAAYPNRIHPRHRRNPRFPALRM||||:| |||||: :||||||||| |||||||||:|||||||| |||||||||||||:|| g616QMGRGNALPAQQIIQCRLKPFQTAFSRFPYPNSHERTQAAYPNGIHPRHRRNPRFPAVRM       190       200       210       220       230       240       250       260       270       280       290       300 m616.pepQHRRCPLRRRNCRLARYAGRTRRKIPAPIQTMPDMAXRGTSMNLPRNRFILLSALWFAGS||||  :|||:  :||:: ||||:||||:|::|::| || :|:|||||| |||||||||: g616QHRRSTVRRRSGTMARHTCRTRRQIPAPVQNLPNVAGRGGGMKLPRNRFSLLSALWFAGG       250       260       270       280       290       300       310       320       330       340       350       360 m616.pepIYSLLFKAAETAPPPFPHFDKVAHLALFFAQIWLLTKAFRLDNRPIPYRSLMVFALCFAL|||||||||:|||||||||||:|||||||||| :|:|||:| : ||||||::||:|||: g616IYSLLFKAADTAPPPFPHFDKAAHLALFFAQILFLAKAFKTGKLPIPYRSLIAFAFCFAV       310       320       330       340       350       360       370       380       390       400 m616.pepFSECAQAWFTATRTGSLGDVLADLTGAALALFTARAACRPDX|||||||||||||||||||||||||||||||:||:|||||| g616GSECAQAWFTATRTGSLGDVLADLTGAALALFAARSACRPDX       370       380       390       400The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1977>:

a616.seq 1 ATGTCAAACA CAATCAAAAT GGTTGTCGGC TTGGGCAACC CGGGCAAAGA 51ATACGAACAG ACACGCCACA ATGCGGGTTT TTGGTTCCTC GACGAACTGG 101 CGTGGAAATGGAAGGCTTCA TTTAAAGAAG AAAAAAAATT CTTCGGCGAA 151 GTCGCCCGTG CTACCCTGCCCGACGGCGAT GTCTGGCTGC TCAAGCCGAC 201 CACGTTCATG AACCGTTCCG GACAGGCAGTTGCCGCCCTT GCGCAGTTTT 251 ATAAAATCAA ACCCGAAGAA ATCCTCGTCG TCCACGACGAACTCGACATT 301 CCCTGCGGAC GGATCAAATT CAAACTCGGC GGCGGCAACG GTGGACACAA351 CGGCTTGAAA GACATTCAGG CAAAACTCGG CACGGCAGAC TATTACCGCC 401TGCGCCTCGG CATCGGCCAC CCGGGCGACC GCAACCTCGT CGTCGGCTAT 451 GTCCTGAACAAACCCAGTAC GGAA.CACCG CCGACAGATT GACGATGCCG 501 TCGCCAAATC CCTGCAAGCCATACCCGACA TCCTTGCCGG CAAATGTGAA 551 GAGGCAACCC GCTTCCTGCA CAGCAAATGACCCGATGCCG TCTGAAGCCC 601 TTTCAGACGG CATGTTCCCG ATTTCCATAT CCGAACAGTCATGACCGAAC 651 TCAAGCAGCT TATCCAAACC GAATCCATCC CCGTCATCGA AGAAACCCTC701 GATTTCCTGC TGTACGAATG CAGCATCGAC GACGCACCAT CCGCCGAAGA 751AGTGGCACAA TGGCGCGACA TACTTGCCGC ACGCGGCGGC AAATTCCTGC 801 GCCTGTCCAAAATCTGCCAA ACGTGGCTGG ACGAGGAGGC GGCATGAAGC 851 TGCCGCGCAA CCGCTTCAGCCTGCTTTCCG CATTGTGGTT TGCCGGCGGC 901 ATCTATTCGC TGCTCTTCAA AGCTGCCGACACCGCGCCGC CGCCGTTTCC 951 GCATTTCGAC AAAGCAGCAC ACCTTGCCCT GTTTTTCGCACAAATCTGGC 1001 TTTTGACCAA AGCATTCAAA ACCGGAAAAC TTCCCATCCC CTACCGCAGC1051 CTGATGGTCT TTGCCCTCTG TTTCGCCCTC TTCAGCGAAT GCGCGCAGGC 1101ATGATTTACC GCAACGAGAA CCGGCAGTTT GGGCGATGTT CTTGCCGATA 1151 TGGCAGGTACGGTTCTCGCA CTCTTTGCCG CCCGCGCCGC CGACCGCCCG 1201 GACTGAThis corresponds to the amino acid sequence <SEQ ID 1978; ORF 616.a>:

a616.pep 1 MSNTIKMVVG LGNPGKEYEQ TRHNAGFWFL DELAWKWKAS FKEEKKFFGE 51VARATLPDGD VWLLKPTTFM NRSGQAVAAL AQFYKIKPEE ILVVHDELDI 101 PCGRIKFKLGGGNGGHNGLK DIQAKLGTAD YYRLRLGIGH PGDRNLVVGY 151 VLNKPSTEXP PTD*RCRRQIPASHTRHPCR QM*RGNPLPA QQMTRCRLKP 201 FQTACSRFPY PNSHDRTQAA YPNRIHPRHRRNPRFPAVRM QHRRRTIRRR 251 SGTMARHTCR TRRQIPAPVQ NLPNVAGRGGGMKLPRNRFS LLSALWFAGG 301 IYSLLFKAAD TAPPPFPHFD KAAHLALFFA QIWLLTKAFKTGKLPIPYRS 351 LMVFALCFAL FSECAQA*FT ATRTGSLGDV LADMAGTVLA LFAARAADRP401 D* m616/a616 90.0% identity in 401 aa overlap        10        20        30        40        50        60 m616.pepMSNTIKMVVGLGNPGKEYEQTRHNAGFWFLDELAWKWKASFKEEKKFFGEVARAALPDGD||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| a616MSNTIKMVVGLGNPGKEYEQTRHNAGFWFLDELAWKWKASFKEEKKFFGEVARATLPDGD        10        20        30        40        50        60        70        80        90       100       110       120 m616.pepVWLLKPATFMNRSGQAVAALAQFYKIKPEEILVVHDELDIPCGRIKFKLGGGNGGHNGLK||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||| a616VWLLKPTTFMNRSGQAVAALAQFYKIKPEEILVVHDELDIPCGRIKFKLGGGNGGHNGLK        70        80        90       100       110       120       130       140       150       160       170       180 m616.pepDIQAKLGTADYYRLRLGIGHPGDRNLVVGYVLNKPSTEXPPTDXRCRRQIPASHTRHPCR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a616DIQAKLGTADYYRLRLGIGHPGDRNLVVGYVLNKPSTEXPPTDXRCRRQIPASHTRHPCR       130       140       150       160       170       180       190       200       210       220       230       240 m616.pepQMGRSNPLPAQQMTRCRLKPFQTACSRFPYPNSHDRTQAAYPNRIHPRHRRNPRFPALRM|| |:||||||||||||||||||||||||||||||||||||||||||||||||||||:|| a616QMXRGNPLPAQQMTRCRLKPFQTACSRFPYPNSHDRTQAAYPNRIHPRHRRNPRFPAVRM       190       200       210       220       230       240       250       260       270       280       290       300 m616.pepQHRRCPLRRRNCRLARYAGRTRRKIPAPIQTMPDMAXRGTSMNLPRNRFILLSALWFAGS||||  :|||:  :||:: ||||:||||:|::|::| || :|:|||||| |||||||||: a616QHRRRTIRRRSGTMARHTCRTRRQIPAPVQNLPNVAGRGGGMKLPRNRFSLLSALWFAGG       250       260       270       280       290       300       310       320       330       340       350       360 m616.pepIYSLLFKAAETAPPPFPHFDKVAHLALFFAQIWLLTKAFRTDNRPIPYRSLMVFALCFAL|||||||||:|||||||||||:|||||||||||||||||:| : |||||||||||||||| a616IYSLLFKAADTAPPPFPHFDKAAHLALFFAQIWLLTKAFKTGKLPIPYRSLMVFALCFAL       310       320       330       340       350       360       370       380       390       400 m616.pepFSECAQAWFTATRTGSLGDVLADLTGAALALFTARAACRPDX||||||| |||||||||||||||::|::||||:|||| |||| a616FSECAQAXFTATRTGSLGDVLADMAGTVLALFAARAADRPDX       370       380       390       400The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1979>:

g619.seq 1 ATGCCGTCTG AAAAAAATAT CGGTTTTATG GCAGGAAGCA GCCGTCCGTT 51GCGGGTCGCC TTTGCGCTGT TGCTGGTTTC CTGCATCCTG TTTATGACGC 101 TCAACGTCAAAGGAGATTGG GACTTTGTCT TGCACCTGCG CCTGACCAAG 151 CTTGCCGCGC TGCTGATGGTCGCCTATGCG GTCGGCGTGT CCACTCAACT 201 CTTCCAAACG CTGACCAACA ACCCGATTCTGACCCCTTCG ATTTTGGGTT 251 TCGATTCGCT GTATGTGTTT TTGCAGACCT TGCTGgtGTTTACGTtcgGC 301 GGCGTGGGCT ATAcatccct gccgttgacg gGCAAATTCG GCTTTGAACT351 GGTTGTTATG ATGGGCGGCT CGCTGCTGCT GTTTTACACG CTCATCCGTC 401AGGGCGGGCG CGATTTGCCG CACATGATTT TAATCGGCGT GATTTTCGGG 451 ATTTTGTTCCGCAGCCTTTC CTCGCTGCTT TCGCGCATGA TAGACCCCGA 501 AGAATTTACC GCCGCGCAGGCGAATATGTT TGCCGGATTC AATACCGTCC 551 GCAGCGAGCT TTTAGGCATA GGCGCGCTGGTCCTGCTCGT CAGCGCGGCG 601 GTCGTTTGGC ACGAACGCTA CCGCTCGGAC GTACACCTTTTGGGGCGCGA 651 CCAAGCCGTC AATTTGGGCA TCAGCTACAC GCGCAACACC TTATGGATAC701 TGCTTTGGAT TGCCGCATTG GTGGCGACGG CGACCGCCGT TGTCGGCCCG 751GTGAGCTTTT TCGGGCTTCT CGCCGCCTCG CTTGCCAACC ACTTTTCCCc 801 gtCCGTGCGCCATTCCGTCC GCCTGCcgat gacggtttGC gtcgGcggCA 851 TCCTCTTGgt cggCggacaAACCGTATTCG AACACTTCTT GGGCATGAag 901 gCggTATTAA GCGTGGTGGt cgAATTTGCGggcggactcG TTTTCCTCTA 951 TCTCGTTTTA AAACACAAAA AATGAThis corresponds to the amino acid sequence <SEQ ID 1980; ORF 619.a>:

g619.pep 1 MPSEKNIGFM AGSSRPLRVA FALLLVSCIL FMTLNVKGDW DFVLHLRLTK 51LAALLMVAYA VGVSTQLFQT LTNNPILTPS ILGFDSLYVF LQTLLVFTFG 101 GVGYTSLPLTGKFGFELVVM MGGSLLLFYT LIRQGGRDLP HMILIGVIFG 151 ILFRSLSSLL SRMIDPEEFTAAQANMFAGF NTVRSELLGI GALVLLVSAA 201 VVWHERYRSD VHLLGRDQAV NLGISYTRNTLWILLWIAAL VATATAVVGP 251 VSFFGLLAAS LANHFSPSVRHSVRLPMTVC VGGILLVGGQ TVFEHFLGMK 301 AVLSVVVEFA GGLVFLYLVL KHKK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1981>:

m619.seq 1 ATGCCGTCTG AAAAAAATAT CGGTTTTATG GCAGGAAGCA GCCGCCCGTT 51GTGGGTCGCC TTTGCGCTGT TGCTGGTTTC CTGCGTCCTG TTTATGACGC 101 TCAACGTCAAAGGCGATTGG GATTTTGTTT TGCAACTGCG GCTGACCAAA 151 CTTGCCGCGC TGCTGATGGTCGCCTATGCG GTCGGCGTGT CCACGCAACT 201 CTTCCAAACG CTGACCAATA ATCCGATTCTGACCCCTTCA ATTTTGGGTT 251 TCGATTCGCT GTATGTGTTT TTGCAGACCT TGCTGGTGTTTACGTTCGGC 301 GGCGTGGGCT ATGCTTCCCT GCCGTTGACG GGCAAATTCG GCTTTGAACT351 GGTCGTCATG ATGGGCGGCT CGCTGCTGCT GTTCTACACG CTCATCAAAC 401AGGGCGGACG CGATTTGTCG CGCATGATTT TAATCGGCGT GATTTTCGGG 451 ATTTTGTTCCGCAGCCTGTC GTCGCTGCTT TCGCGCATGA TCGATCCCGA 501 AGAATTTACC GCCGCGCAGGCGAATATGTT TGCCGGATTC AATACCGTCC 551 ACAGCGAGCT TTTGGGCATA GGCGCGCTGATTCTGCTCGT CAGCGCGGCG 601 GTCGTTTGGC GCGAACGCTA CCGCTTGGAC GTTTACCTTTTGGGGCGTGA 651 CCAAGCCGTC AATTTGGGCA TCAGCTACAC GCGCAACACC TTATGGATAC701 TGCTTTGGAT TGCCGCATTG GTGGCGACGG CGACCGCCGT GGTCGGCCCC 751GTAAGCTTTT TCGGGCTTCT CGCCGCCTCG CTTGCCAACC ACTTTTCCCC 801 GTCGGTCAAACATTCCGTCC GCCTGCCGAT GACGGTTTGT ATCGGCGGCA 851 TCCTCTTGGT CGGCGGACAGACCGTGTTCG AACACCTGCT CGGTATGCAG 901 GCAGTGTTGA GCGTAGTAGT AGAATTTGCCGGCGGACTCG TTTTCCTCTA 951 TCTCGTTTTA AAACACAAAA AATGAThis corresponds to the amino acid sequence <SEQ ID 1982: ORF 619>:

m619.pep 1 MPSEKNIGFM AGSSRPLWVA FALLLVSCVL FMTLNVKGDW DFVLQLRLTK 51LAALLMVAYA VGVSTQLFQT LTNNPILTPS ILGFDSLYVF LQTLLVFTFG 101 GVGYASLPLTGKFGFELVVM MGGSLLLFYT LIKQGGRDLS RMILIGVIFG 151 ILFRSLSSLL SRMIDPEEFTAAQANMFAGF NTVHSELLGI GALILLVSAA 201 VVWRERYRLD VYLLGRDQAV NLGISYTRNTLWILLWIAAL VATATAVVGP 251 VSFFGLLAAS LANHFSPSVKHSVRLPMTVC IGGILLVGGQ TVFEHLLGMQ 301 AVLSVVVEFA GGLVFLYLVL KHKK*m619/g619 95.1% identity in 324 aa overlap        10        20        30        40        50        60 m619.pepMPSEKNIGFMAGSSRPLWVAFALLLVSCVLFMTLNVKGDWDFVLQLRLTKLAALLMVAYA||||||||||||||||| ||||||||||:|||||||||||||||:||||||||||||||| g619MPSEKNIGFMAGSSRPLRVAFALLLVSCILFMTLNVKGDWDFVLHLRLTKLAALLMVAYA        10        20        30        40        50        60        70        80        90       100       110       120 m619.pepVGVSTQLFQTLTNNPILTPSILGFDSLYVFLQTLLVFTFGGVGYASLPLTGKFGFELVVM||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||| g619VGVSTQLFQTLTNNPILTPSILGFDSLYVFLQTLLVFTFGGVGYTSLPLTGKFGFELVVM        70        80        90       100       110       120       130       140       150       160       170       180 m619.pepMGGSLLLFYLLIKQGGRDLSRMILIGVIFGILFRSLSSLLSRMIDPEEFTAAQANMFAGF||||||||||||:|||||| :||||||||||||||||||||||||||||||||||||||| g619MGGSLLLFYLLIRQGGRDLPHMILIGVIFGILFRSLSSLLSRMIDPEEFTAAQANMFAGF       130       140       150       160       170       180       190       200       210       220       230       240 m619.pepNTVHSELLGIGALILLVSAAVVWRERYRLDVYLLGRDQAVNLGISYTRNTLWILLWIAAL|||:|||||||||:|||||||||:|||| ||:|||||||||||||||||||||||||||| g619NTVRSELLGIGALVLLVSAAVVWHERYRSDVHLLGRDQAVNLGISYTRNTLWILLWIAAL       190       200       210       220       230       240       250       260       270       280       290       300 m619.pepVATATAVVGPVSFFGLLAASLANHFSPSVKHSVRLPMTVCIGGILLVGGQTVFEHLLGMQ|||||||||||||||||||||||||||||:||||||||||:||||||||||||||:|||: g619VATATAVVGPVSFFGLLAASLANHFSPSVRHSVRLPMTVCVGGILLVGGQTVFEHFLGMK       250       260       270       280       290       300       310       320 m619.pep AVLSVVVEFAGGLVFLYLVLKHKKX||||||||||||||||||||||||| g619 AVLSVVVEFAGGLVFLYLVLKHKKX       310       320The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1983>:

a619.seq 1 ATGCCGTCTG AAAAAAATAT CGGTTTTATG GCAGGAAGCA GCCGTCCGTT 51GTGGGTTGCC TTTGCGCTGT TGCTGGTTTC CTGCATCCTG TTTATGACGC 101 TCAACGTCAAAGGCGATTGG GATTTTGTTT TGCACCTGCG CCTGACCAAG 151 CTTGCCGCGC TGCTGATGGTCGCCTATGCG GTCGGCGTTT CGACCCAGCT 201 TTTTCAAACG CTGACCAACA ATCCGATTCTGACCCCTTCG ATTTTGGGTT 251 TCGATTCGCT GTATGTGTTT TTGCAGACCT TGCTGGTGTTTACGTTCGGC 301 GGCGTGGGCT ATGCTTCCCT GCCGTTGACG GGCAAATTCG GCTTTGAACT351 GGTCGTTATG ATGGGCGGCT CGCTGCTGCT GTTTTACACG CTCATCAAAC 401AGGGCGGGCG CGATTTGCCG CGTATGATTT TAATCGGCGT GATTTTCGGG 451 ATTTTGTTCCGCAGCCTGTC GTCGCTGCTT TCGCGCATGA TCGACCCCGA 501 AGAATTTACG GCGGCGCAGGCGAATATGTT TGCCGGATTC AATACCGTCC 551 ACAGCGAGCT TTTAGGCATA GGCGCGCTGATTCTGCTCGT CAGCGCGGCG 601 GTCGTTTGGC GCGAACGCTA CCGCTTGGAC GTACACCTTTTGGGGCGCGA 651 CCAAGCCATA AATTTGGGCA TCAGCTACAC GCGCAACACC TTATGGATAC701 TGCTTTGGAT TGCCGCGCTG GTGGCGACGG CGACCGCCGT TGTCGGCCCG 751GTAAGCTTTT TCGGGCTTCT CGCCGCCTCG CTTGCCAACC ACTTTTCCCC 801 GTCGGTCAAACATTCCGTCC GCCTGCCGAT GACGGTTTGT GTCGGCGGCA 851 TCCTCTTGGT CGGCGGACAGACCGTATTCG AACACTTCTT GGGCATGAAG 901 GCGGTATTAA GCGTGGTGGT CGAATTTGCGGGCGGACTCG TTTTCCTCTA 951 TCTCGTTTTA AGACACAAAA AATGAThis corresponds to the amino acid sequence <SEQ ID 1984; ORF 619.a>:

a619.pep 1 MPSEKNIGFM AGSSRPLWVA FALLLVSCIL FMTLNVKGDW DFVLHLRLTK 51LAALLMVAYA VGVSTQLFQT LTNNPILTPS ILGFDSLYVF LQTLLVFTFG 101 GVGYASLPLTGKFGFELVVM MGGSLLLFYT LIKQGGRDLP RMILIGVIFG 151 ILFRSLSSLL SRMIDPEEFTAAQANMFAGF NTVHSELLGI GALILLVSAA 201 VVWRERYRLD VHLLGRDQAI NLGISYTRNTLWILLWIAAL VATATAVVGP 251 VSFFGLLAAS LANHFSPSVKHSVRLPMTVC VGGILLVGGQ TVFEHFLGMK 301 AVLSVVVEFA GGLVFLYLVL RHKK*m619/a619 97.2% identity in 324 aa overlap        10        20        30        40        50        60 m619.pepMPSEKNIGFMAGSSRPLWVAFALLLVSCVLFMTLNVKGDWDFVLQLRLTKLAALLMVAYA||||||||||||||||||||||||||||:|||||||||||||||:||||||||||||||| a619MPSEKNIGFMAGSSRPLWVAFALLLVSCILFMTLNVKGDWDFVLHLRLTKLAALLMVAYA        10        20        30        40        50        60        70        80        90       100       110       120 m619.pepVGVSTQLFQTLTNNPILTPSILGFDSLYVFLQTLLVFTFGGVGYASLPLTGKFGFELVVM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a619VGVSTQLFQTLTNNPILTPSILGFDSLYVFLQTLLVFTFGGVGYASLPLTGKFGFELVVM        70        80        90       100       110       120       130       140       150       160       170       180 m619.pepMGGSLLLFYTLIKQGGRDLSRMILIGVIFGILFRSLSSLLSRMIDPEEFTAAQANMFAGF||||||||||||||||||| |||||||||||||||||||||||||||||||||||||||| a619MGGSLLLFYTLIKQGGRDLPRMILIGVIFGILFRSLSSLLSRMIDPEEFTAAQANMFAGF       130       140       150       160       170       180       190       200       210       220       230       240 m619.pepNTVHSELLGIGALILLVSAAVVWRERYRLDVYLLGRDQAVNLGISYTRNTLWILLWIAAL|||||||||||||||||||||||||||||||:|||||||:|||||||||||||||||||| a619NTVHSELLGIGALILLVSAAVVWRERYRLDVHLLGRDQAINLGISYTRNTLWILLWIAAL       190       200       210       220       230       240       250       260       270       280       290       300 m619.pepVATATAVVGPVSFFGLLAASLANHFSPSVKHSVRLPMTVCIGGILLVGGQTVFEHLLGMQ||||||||||||||||||||||||||||||||||||||||:||||||||||||||:|||: a619VATATAVVGPVSFFGLLAASLANHFSPSVKHSVRLPMTVCVGGILLVGGQTVFEHFLGMK       250       260       270       280       290       300       310       320 m619.pep AVLSVVVEFAGGLVFLYLVLKHKKX||||||||||||||||||||:|||| a619 AVLSVVVEFAGGLVFLYLVLRHKKX       310       320The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1985>:

g620.seq 1 ATGAAGAAAA CCCTGTTGGc AATTGTTGCC gtTTTCGCCT TAAGTGCCTG 51CCGGCaggcg gaAGaggcac cgccgCCTTT ACCCCGGCAG AtTAGCGacc 101 gttcggtcggaCACTAttgC Agtatgaacc tgaccgaaca caacggcccc 151 aaagcccaga tttttttgaacGGCAAACCC GATCAGCCCG TTTGGTTCTC 201 CACCGTcaag cagatgttcg GCTATACCAAGCTGCCCGAA GAGCCCAAAG 251 GCATCCGCGT GATTTACGTT ACCGATATGG GCAATGTTACCGATTGGACG 301 AATCCTAATG CCGACACGGA GTGGATAGAT GCGAAAAAAG CCTTTTACGT351 CATCGACAGC GGCTTTATCG GCGGTATGGG CGCGGAAGAC GCGCTGCCGT 401TCGGCAACAA GGAGCAGGCT GAAAAATTTG CAAAGGATAA AGGCGGCAAG 451 GTCGTCGGTTTTGACGATAT GCCCGATGCT TACATTTTCA AGTAAThis corresponds to the amino acid sequence <SEQ ID 1986; ORF 620.ng>:

g620.pep 1 MKKTLLAIVA VFALSACRQA EEAPPPLPRQ ISDRSVGHYC SMNLTEHNGP 51KAQIFLNGKP DQPVWFSTVK QMFGYTKLPE EPKGIRVIYV TDMGNVTDWT 101 NPNADTEWIDAKKAFYVIDS GFIGGMGAED ALPFGNKEQA EKFAKDKGGK 151 VVGFDDMPDA YIFK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1987>:

m620.seq 1 ATGAAAAAAA CCCTGTTGGC AATTGTTGCC GTTTCCGCCT TAAGTGCCTG 51CCGGCAGGCG GAAGAGGGAC CGCCGCCTTT ACCCCGGCAG ATTAGCGACC 101 GTTCGGTCGGACACTATTGC AGTATGAACC TGACCGAACA CAACGGCCCC 151 AAAGCCCAGA TTTTCTTGAACGGCAAACCC GATCAGCCCG TTTGGTTCTC 201 CACCATCAAG CAGATGTTCG GCTATACCAAGCTGCCCGAA GAGCCTAAAG 251 GCATCCGCGT GATTTACGTT ACCGATATGG GCAATGTTACCGATTGGACG 301 AATCCCAATG CCGACACGGA GTGGATGGAT GCGAAAAAAG CCTTTTACGT351 CATCGACAGC GGCTTTATCG GCGGTATGGG TGCGGAAGAC GCGCTGCCGT 401TCGGCAACAA AGAGCAGGCT GAGAAATTTG CAAAGGATAA AGGCGGTAAG 451 GTTGTCGGTTTCGACGATAT GCCTGATACC TATATTTTCA AATAAThis corresponds to the amino acid sequence <SEQ ID 1988: ORF 620>:

m620.pep 1 MKKTLLAIVA VSALSACRQA EEGPPPLPRQ ISDRSVGHYC SMNLTEHNGP 51KAQIFLNGKP DQPVWFSTIK QMFGYTKLPE EPKGIRVIYV TDMGNVTDWT 101 NPNADTEWMDAKKAFYVIDS GFIGGMGAED ALPFGNKEQA EKFAKDKGGK 151 VVGFDDMPDT YIFK*m620/g620 97.0% identity in 164 aa overlap        10        20        30        40        50        60 m620.pepMKKTLLAIVAVSALSACRQAEEGPPPLPRQISDRSVGHYCSMNLTEHNGPKAQIFLNGKP||||||||||| ||||||||||:||||||||||||||||||||||||||||||||||||| g620MKKTLLAIVAVFALSACRQAEEAPPPLPRQISDRSVGHYCSMNLTEHNGPKAQIFLNGKP        10        20        30        40        50        60        70        80        90       100       110       120 m620.pepDQPVWFSTIKQMFGYTKLPEEPKGIRVIYVTDMGNVTDWTNPNADTEWMDAKKAFYVIDS||||||||:|||||||||||||||||||||||||||||||||||||||:||||||||||| g620DQPVWFSTVKQMFGYTKLPEEPKGIRVIYVTDMGNVTDWTNPNADTEWIDAKKAFYVIDS        70        80        90       100       110       120       130       140       150       160 m620.pepGFIGGMGAEDALPFGNKEQAEKFAKDKGGKVVGFDDMPDTYIFKX|||||||||||||||||||||||||||||||||||||||:||||| g620GFIGGMGAEDALPFGNKEQAEKFAKDKGGKVVGFDDMPDAYIFKX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1989>:

a620.seq 1 ATGAAAAAAA CCCTGTTGGC AATTGTTGCC GTTTCCGCCT TAAGTGCCTG 51CCGGCAGGCG GAAGAGGGAC CGCCGCCTTT ACCCCGGCAG ATTAGCGACC 101 GTTCGGTCGGACACTATTGC AGTATGAACC TGACCGAACA CAACGGCCCC 151 AAAGCCCAGA TTTTCTTGAACGGCAAACCC GATCAGCCCG TTTGGTTCTC 201 CACCATCAAG CAGATGTTCG GCTATACCAAGCTGCCCGAA GAGCCTAAAG 251 GCATCCGCGT GATTTACGTT ACCGATATGG GCAATGTTACCGATTGGACG 301 AATCCCAATG CCGACACGGA GTGGATGGAT GCGAAAAAAG CCTTTTACGT351 CATCGACAGC GGCTTTATCG GCGGTATGGG TGCGGAAGAC GCGCTGCCGT 401TCGGCAACAA AGAGCAGGCT GAGAAATTTG CAAAGGATAA AGGCGGTAAG 451 GTTGTCGGTTTCGACGATAT GCCTGATACC TATATTTTCA AATAAThis corresponds to the amino acid sequence <SEQ ID 1990; ORF 620.a>:

a620.pep 1 MKKTLLAIVA VSALSACRQA EEGPPPLPRQ ISDRSVGHYC SMNLTEHNGP 51KAQIFLNGKP DQPVWFSTIK QMFGYTKLPE EPKGIRVIYV TDMGNVTDWT 101 NPNADTEWMDAKKAFYVIDS GFIGGMGAED ALPFGNKEQA EKFAKDKGGK 151 VVGFDDMPDT YIFK*m620/a620 100.0% identity in 164 aa overlap        10        20        30        40        50        60 m620.pepMKKTLLAIVAVSALSACRQAEEGPPPLPRQISDRSVGHYCSMNLTEHNGPKAQIFLNGKP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a620MKKTLLAIVAVSALSACRQAEEGPPPLPRQISDRSVGHYCSMNLTEHNGPKAQIFLNGKP        10        20        30        40        50        60        70        80        90       100       110       120 m620.pepDQPVWFSTIKQMFGYTKLPEEPKGIRVIYVTDMGNVTDWTNPNADTEWMDAKKAFYVIDS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a620DQPVWFSTIKQMFGYTKLPEEPKGIRVIYVTDMGNVTDWTNPNADTEWMDAKKAFYVIDS        70        80        90       100       110       120       130       140       150       160 m620.pepGFIGGMGAEDALPFGNKEQAEKFAKDKGGKVVGFDDMPDTYIFKX||||||||||||||||||||||||||||||||||||||||||||| a620GFIGGMGAEDALPFGNKEQAEKFAKDKGGKVVGFDDMPDTYIFKX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1991>:

g622.seq 1 ATGCAactta ccgctgtcgg ACTCAATCAT CAAACCGCAC CTTTAAGCAT 51ACGGGAAAag ctggCGTTTG CCGCCGCCGC CCTGCCAGAA gccgTccgCA 101 ATCTTGCCCGAAGCAATGCG GCAACGGAGG CGGTAATCCT TTCTACCTGC 151 AACCGCACCG AGCTTTACTGCGTCGGCGAT TCGGAAgaaa TCATCCGATG 201 GCTTGCCGAT TACCACAGTT TGCCGATTGAAGAAATCCGT CCGTATCTGT 251 ACACGCTGGA TATGCAGGAA ACCGTGCGCC ACGCCTTCCGCGTTGCCTGC 301 GGCTTGGATT CGATGGTTTT GGGCGAGCCG CAGATTTTGG GGCAGATTAA351 AGATGCGGTG CGTGCGGCTC AAGAACAGGA AAGTATGGGG GCAAAACTCA 401ATGCCCTGTT CCAAAAAACC TTTTCCGTTG CTAAAGAAGT CCGTACCGAT 451 ACCGCTGTCGGCGAAAATTC GGTTTCGATG GCTTCCGCGT CCGTCAAGTT 501 GGCGGAACAG ATTTTTCCCGACATCGGCGA TTTGAACGTA TTGTTTATCG 551 GCGCAGGCGA AATGATTGAG CTGGTTGCCACTTATTTTGC CGCCAAAAAT 601 CCCCGGCTGA TGACGGTTGC CAACCGGACG CTGGCGCGTGCACAGGAGTT 651 GTGCGACAAG CTCGGTGTTA ACGCCGAACC GTGCCTGCTG TCCGATCTGC701 CTGCCATTCT GCACGATTAC GACGTGGTGG TTTCTTCAAC GGCGAGCCAG 751CTTCCGATAG TCGGCAAAGG CATGGTCGAA CGCGCATTGA AACAGCGTCA 801 GAGTATGCCGTTGTTCATGC TTGACTTGGC CGTGCCGCGC GATATTGAAG 851 CGGAAGTCGG CGATTTGAACGATGCGTATC TTTATACGGT GGACGATATG 901 GTCAACATCG TCCAAAGCGg caaggaggcaaggcagaaag ccgccgcCgc 951 cgccgaaacg ctggTGTCCG AAAAGGTTGC CGAATTTGTCAGGCAGCAGC 1001 AGGGCAGGCA GagcgttcCG CTGATTAAGG CCTTGCGGGA CGAGGGCGAG1051 AAAGCGCGCA AGCAGGTGTT GGAAAATGCG ATGAAACAGC TTGCCAAAGG 1101CGcaaCGGCG GAAGaggttt TGgaacggct gtccgtcCAA CTGACCAACA 1151 AGCTGCTGCATTCGCCAACT CAAACCTTGA ATAAGGCGGG GGAAGAAGAT 1201 AAAGatttGG TTCATGCCgtcGCGCAGATt tatcatttGG ACAAATAAThis corresponds to the amino acid sequence <SEQ ID 1992; ORF 622.ng>:

g622.pep 1 MQLTAVGLNH QTAPLSIREK LAFAAAALPE AVRNLARSNA ATEAVILSTC 51NRTELYCVGD SEEIIRWLAD YHSLPIEEIR PYLYTLDMQE TVRHAFRVAC 101 GLDSMVLGEPQILGQIKDAV RAAQEQESMG AKLNALFQKT FSVAKEVRTD 151 TAVGENSVSM ASASVKLAEQIFPDIGDLNV LFIGAGEMIE LVATYFAAKN 201 PRLMTVANRT LARAQELCDK LGVNAEPCLLSDLPAILHDY DVVVSSTASQ 251 LPIVGKGMVE RALKQRQSMP LFMLDLAVPR DIEAEVGDLNDAYLYTVDDM 301 VNIVQSGKEA RQKAAAAAET LVSEKVAEFV RQQQGRQSVP LIKALRDEGE351 KARKQVLENA MKQLAKGATA EEVLERLSVQ LTNKLLHSPT QTLNKAGEED 401KDLVHAVAQI YHLDK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1993>:

m622.seq 1 ATGCAACTTA CCGCTGTCGG ACTCAATCAT CAAACCGCAC CTTTAAGCAT 51ACGGGAAAAG CTGGCGTTTG CCGCCGCCGC CCTGCCTAAA GCCGTCCGCA 101 ATCTTGCCCGAAGCAATGCG GCAACGGAGG CGGTAATCCT TTCTACCTGC 151 AACCGCACCG AGCTTTACTGCGTCGGTGAT TCGGAAGAAA TCATCCGATG 201 GCTTGCCGAT TACCACAGTT TGCCGATTGAAGAAATCCGT CCGTATCTGT 251 ACGCGCTGGA TATGCAGGAG ACTGTGCGCC ATGCTTTCCGCGTCGCCTGC 301 GGGCTGGATT CGATGGTGTT GGGCGAGCCG CAGATTTTAG GACAGATTAA351 GGATGCCGTT AGGGTTGCTC AAGAGCAGGA AAGTATGGGT AAGAAACTCA 401ATGCCCTGTT CCAAAAAACC TTTTCCGTTG CTAAAGAGGT CCGTACCGAT 451 ACTGCCGTCGGCGAAAACTC GGTTTCCATG GCTTCCGCTT CCGTCAAATT 501 GGCGGAACAG ATTTTTCCCGACATCGGCGA TTTGAATGTC TTGTTTATCG 551 GCGCAGGCGA AATGATTGAG CTGGTTGCCACTTATTTTGC CGCCAAAAGT 601 CCCCGGCTGA TGACGGTTGC CAACCGGACG CTGGCGCGTGCACAGGAGTT 651 GTGCGACAAG CTCGGTGTCA ACGCCGAACC GTGCCTGCTG TCCGATCTGC701 CTGCCATTCT GCACGATTAC GACGTAGTGG TTTCTTCAAC GGCAAGCCAG 751TTGCCCATTG TCGGCAAAGG CATGGTGGAG CGTGCATTGA AACAAAGGCA 801 GAGTATGCCGTTGTTCATGC TTGATTTGGC AGTGCCGCGT GACATTGAAG 851 CGGAAGTCGG CGATTTGAATGATGCCTATC TTTATACGGT GGACGATATG 901 GTCAATATCG TCCAAAGCGG CAAGGAGGCAAGGCAGAAGG CCGCCGCCGC 951 CGCCGAAACG CTGGTGTCCG AGAAAGTTGC CGAATTTGTCAGGCAGCAGC 1001 AGGGCAGGCA GAGTGTCCCC TTGATTAAGG CGTTGCGGGA CGAGGGCGAG1051 AAAGCGCGCA AACAGGTGTT GGAAAATGCC ATGAAACAGC TTGCCAAAGG 1101CGCAACGGCA GAAGAGGTTT TGGAACGGCT GTCCGTCCAA CTGACCAACA 1151 AGCTGCTGCATTCGCCGACC CAAACCTTGA ATAAGGCGGG GGAAGAAGAT 1201 AAAGATTTGG TTCATGCCGTCGCGCAGATT TATCATTTGG ACAAATAAThis corresponds to the amino acid sequence <SEQ ID 1994; ORF 622>:

m622.pep 1 MQLTAVGLNH QTAPLSIREK LAFAAAALPK AVRNLARSNA ATEAVILSTC 51NRTELYCVGD SEEIIRWLAD YHSLPIEEIR PYLYALDMQE TVRHAFRVAC 101 GLDSMVLGEPQILGQIKDAV RVAQEQESMG KKLNALFQKT FSVAKEVRTD 151 TAVGENSVSM ASASVKLAEQIFPDIGDLNV LFIGAGEMIE LVATYFAAKS 201 PRLMTVANRT LARAQELCDK LGVNAEPCLLSDLPAILHDY DVVVSSTASQ 251 LPIVGKGMVE RALKQRQSMP LFMLDLAVPR DIEAEVGDLNDAYLYTVDDM 301 VNIVQSGKEA RQKAAAAAET LVSEKVAEFV RQQQGRQSVP LIKALRDEGE351 KARKQVLENA MKQLAKGATA EEVLERLSVQ LTNKLLHSPT QTLNKAGEED 401KDLVHAVAQI YHLDK* m622/g622 98.8% identity in 415 aa overlap        10        20        30        40        50        60 m622.pepMQLTAVGLNHQTAPLSIREKLAFAAAALPKAVRNLARSNAATEAVILSTCNRTELYCVGD|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| g622MQLTAVGLNHQTAPLSIREKLAFAAAALPEAVRNLARSNAATEAVILSTCNRTELYCVGD        10        20        30        40        50        60        70        80        90       100       110       120 m622.pepSEEIIRWLADYHSLPIEEIRPYLYALDMQETVRHAFRVACGLDSMVLGEPQILGQIKDAV||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||| g622SEEIIRWLADYHSLPIEEIRPYLYTLDMQETVRHAFRVACGLDSMVLGEPQILGQIKDAV        70        80        90       100       110       120       130       140       150       160       170       180 m622.pepRVAQEQESMGKKLNALFQKTFSVAKEVRTDTAVGENSVSMASASVKLAEQIFPDIGDLNV|:|||||||| ||||||||||||||||||||||||||||||||||||||||||||||||| g622RAAQEQESMGAKLNALFQKTFSVAKEVRTDTAVGENSVSMASASVKLAEQIFPDIGDLNV       130       140       150       160       170       180       190       200       210       220       230       240 m622.pepLFIGAGEMIELVATYFAAKSPRLMTVANRTLARAQELCDKLGVNAEPCLLSDLPAILHDY|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||| g622LFIGAGEMIELVATYFAAKNPRLMTVANRTLARAQELCDKLGVNAEPCLLSDLPAILHDY       190       200       210       220       230       240       250       260       270       280       290       300 m622.pepDVVVSSTASQLPIVGKGMVERALKQRQSMPLFMLDLAVPRDIEAEVGDLNDAYLYTVDDM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g622DVVVSSTASQLPIVGKGMVERALKQRQSMPLFMLDLAVPRDIEAEVGDLNDAYLYTVDDM       250       260       270       280       290       300       310       320       330       340       350       360 m622.pepVNIVQSGKEARQKAAAAAELLVSEKVAEFVRQQQGRQSVPLIKALRDEGEKARKQVLENA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g622VNIVQSGKEARQKAAAAAETLVSEKVAEFVRQQQGRQSVPLIKALRDEGEKARKQVLENA       310       320       330       340       350       360       370       380       390       400       410 m622.pepMKQLAKGATAEEVLERLSVQLTNKLLHSPTQTLNKAGEEDKDLVHAVAQIYHLDKX|||||||||||||||||||||||||||||||||||||||||||||||||||||||| g622MKQLAKGATAEEVLERLSVQLTNKLLHSPTQTLNKAGEEDKDLVHAVAQIYHLDKX       370       380       390       400       410The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1995>:

a622.seq 1 ATGCAACTTA CCGCTGTCGG ACTCAATCAT CAAACCGCAC CTTTAAGCAT 51ACGGGAAAAG CTGGCGTTTG CCGCGGCCTG CCTGCCCGAA GCCGTCCGCA 101 ATCTTGCCCGAAGCAATGCG GCAACGGAGG CGGTAATCCT TTCTACCTGC 151 AACCGTACCG AGCTTTACTGTGTAGGTGAT TCGGAAGAAA TCATCCGTTG 201 GCTCGCAGAC TATCACAGCC TTCCCATAGAAGAAATCAGC CCCTACCTTT 251 ATACTTTGGG GATGCAGGAG ACTGTGCGCC ATGCTTTCCGCGTCGCCTGC 301 GGCTTGGATT CGATGGTGTT GGGCGAGCCG CAGATTTTAG GACAGATTAA351 GGATGCGGTC AGGGTTGCTC AAGAGCAGGA AAGTATGGGT AAGAAACTCA 401ATGCCCTGTT CCAAAAAACC TTTTCTGTTG CTAAAGAGGT CCGTACCGAT 451 ACTGCCGTCGGCGAAAACTC GGTTTCCATG GCTTCCGCTT CCGTCAAGTT 501 GGCAGAGCAG ATTTTCCCCGACATCGGCGA TTTGAATGTC TTGTTTATCG 551 GTGCGGGTGA GATGATTGAG CTGGTTGCCACTTATTTTGC CGCCAAAAGT 601 CCCCGGCTGA TGACGGTTGC CAACCGGACG CTGGCGCGTGCACAGGAGTT 651 GTGCGACAAG CTCGGTGTCA ACGCCGAACC GTGCCTGCTG TCCGATCTGC701 CTGCCATTTT GCATGAGTAC GACGTGGTGG TTTCTTCAAC GGCAAGCCAG 751TTGCCCATTG TCGGCAAAGG TATGGTGGAG CGCGCATTGA AACAAAGGCA 801 GAGTATGCCGTTGTTTATGC TTGACTTGGC CGTGCCGCGA GACATTGAGG 851 CGGAAGTCGG AGATTTGAACGATGCCTATC TTTATACGGT GGACGATATG 901 GTCAATATCG TCCAAAGCGG CAAGGAGGCAAGGCAGAAGG CCGCCGCCGC 951 CGCCGAAACG CTGGTGTCCG AGAAGGTTGC CGAATTTGTCAGGCAGCAGC 1001 AGGGCAGGCA GAGTGTCCCG TTAATCAGGG CATTGAGGGA TGAGGGAGAG1051 AAAGCGCGCA AACAGGTCTT GGAAAATGCG ATGAAACAGC TTGCCAAAGG 1101CGCAACGGCA GAAGAGGTTT TGGAAAGGCT GTCGATCCAA CTGACCAACA 1151 AGCTGCTGCATTCGCCGACC CAAACCTTGA ATAAGGCGGG GGAAGAAGAT 1201 AAAGATTTGG TTCACGCCGTCGCGCAGATT TATCATTTGG ACAAATAAThis corresponds to the amino acid sequence <SEQ ID 1996; ORF 622.a>:

a622.pep 1 MQLTAVGLNH QTAPLSIREK LAFAAACLPE AVRNLARSNA ATEAVILSTC 51NRTELYCVGD SEEIIRWLAD YHSLPIEEIS PYLYTLGMQE TVRHAFRVAC 101 GLDSMVLGEPQILGQIKDAV RVAQEQESMG KKLNALFQKT FSVAKEVRTD 151 TAVGENSVSM ASASVKLAEQIFPDIGDLNV LFIGAGEMIE LVATYFAAKS 201 PRLMTVANRT LARAQELCDK LGVNAEPCLLSDLPAILHEY DVVVSSTASQ 251 LPIVGKGMVE RALKQRQSMP LFMLDLAVPR DIEAEVGDLNDAYLYTVDDM 301 VNIVQSGKEA RQKAAAAAET LVSEKVAEFV RQQQGRQSVP LIRALRDEGE351 KARKQVLENA MKQLAKGATA EEVLERLSIQ LTNKLLHSPT QTLNKAGEED 401KDLVHAVAQI YHLDK* m622/a622 98.1% identity in 415 aa overlap        10        20        30        40        50        60 m622.pepMQLTAVGLNHQTAPLSIREKLAFAAAALPKAVRNLARSNAATEAVILSTCNRTELYCVGD|||||||||||||||||||||||||| ||:|||||||||||||||||||||||||||||| a622MQLTAVGLNHQTAPLSIREKLAFAAACLPEAVRNLARSNAATEAVILSTCNRTELYCVGD        10        20        30        40        50        60        70        80        90       100       110       120 m622.pepSEEIIRWLADYHSLPIEEIRPYLYALDMQETVRHAFRVACGLDSMVLGEPQILGQIKDAV||||||||||||||||||| ||||:| ||||||||||||||||||||||||||||||||| a622SEEIIRWLADYHSLPIEEISPYLYTLGMQETVRHAFRVACGLDSMVLGEPQILGQIKDAV        70        80        90       100       110       120       130       140       150       160       170       180 m622.pepRVAQEQESMGKKLNALFQKTFSVAKEVRTDTAVGENSVSMASASVKLAEQIFPDIGDLNV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a622RVAQEQESMGKKLNALFQKTFSVAKEVRTDTAVGENSVSMASASVKLAEQIFPDIGDLNV       130       140       150       160       170       180       190       200       210       220       230       240 m622.pepLFIGAGEMIELVATYFAAKSPRLMTVANRTLARAQELCDKLGVNAEPCLLSDLPAILHDY||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:| a622LFIGAGEMIELVATYFAAKSPRLMTVANRTLARAQELCDKLGVNAEPCLLSDLPAILHEY       190       200       210       220       230       240       250       260       270       280       290       300 m622.pepDVVVSSTASQLPIVGKGMVERALKQRQSMPLFMLDLAVPRDIEAEVGDLNDAYLYTVDDM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a622DVVVSSTASQLPIVGKGMVERALKQRQSMPLFMLDLAVPRDIEAEVGDLNDAYLYTVDDM       250       260       270       280       290       300       310       320       330       340       350       360 m622.pepVNIVQSGKEARQKAAAAAETLVSEKVAEFVRQQQGRQSVPLIKALRDEGEKARKQVLENA||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||| a622VNIVQSGKEARQKAAAAAETLVSEKVAEFVRQQQGRQSVPLIRALRDEGEKARKQVLENA       310       320       330       340       350       360       370       380       390       400       410 m622.pepMKQLAKGATAEEVLERLSVQLTNKLLHSPTQTLNKAGEEDKDLVHAVAQIYHLDKX||||||||||||||||||:||||||||||||||||||||||||||||||||||||| a622MKQLAKGATAEEVLERLSIQLTNKLLHSPTQTLNKAGEEDKDLVHAVAQIYHLDKX       370       380       390       400       410The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 1997>:

g624.seq 1 ATGATCCGTT ATCTTTTAAT TGCCTGCGGC GGCATCTCCC TGCTGTTGGG 51GATAATCGGC ATTTTTTTGC CGCTGTTGCC GACCACGCCG TTCGTACTAC 101 TCTCCGCCGCCTGCTGGGCA AAGGCAtccc cgcgcTTTCa ccgCTGGCTG 151 CACcgGCacc gCTATTTCGGCCCGATGGTT CATAACTGGG AACAAAACGG 201 CGCAGTGCCG CGCAAAGCCA AGATTTTCGCCATCAGCATG AtaaccgcAt 251 cctgcctcat gatctTTtgg CattTTCccc aacnctggtgggtcGGGGCG 301 GTTTCATCGG TTTTTTGTTC CCTTGTcacC ATacggatgt gGcacAGacC351 cgaatCTTGAThis corresponds to the amino acid sequence <SEQ ID 1998; ORF 624.ng>:

g624.pep 1 MIRYLLIACG GISLLLGIIG IFLPLLPTTP FVLLSAACWA KASPRFHRWL 51HRHRYFGPMV HNWEQNGAVP RKAKIFAISM ITASCLMIFW HFPQXWWVGA 101 VSSVFCSLVTIRMWHRPES*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 1999>:

m624.seq 1 ATGATACGTT ATCTTTTAAT TGCCTGCGGC TGCATTTCCC TACTGTTGGG 51TATCATCGGC ATTTTTTTGC CGCTGTTGCC GACCACGCCG TTCGTACTGC 101 TCTCCGCCGCCTGCTGGGCA AAGGCATCCC CGCGCTTTTA CCGCTGGCTG 151 CACCGGCACC GCTATTTCGGCCCGATGGTT CATAACTGGG AACAAAACGG 201 CGCAGTGCCG CGCAAAGCCA AAATATTCGCCATCAGTATG ATGACCGCAT 251 CCTGCCTGAT AATGTTTTGG CAGTTTCCCC AACGCTGGTGGGTCGGGGCG 301 GTTTCATCGG TTTTTTGTTC CCTTGTCGCC ATATGGATGT GGCGCAGGCC351 CGAATCTTGAThis corresponds to the amino acid sequence <SEQ ID 2000; ORF 624>:

m624.pep 1 MIRYLLIACG CISLLLGIIG IFLPLLPTTP FVLLSAACWA KASPRFYRWL 51HRHRYFGPMV HNWEQNGAVP RKAKIFAISM MTASCLIMFW QFPQRWWVGA 101 VSSVFCSLVAIWMWRRPES* m624/g624 91.6% identity in 119 aa overlap        10        20        30        40        50        60 m624.pepMIRYLLIACGCISLLLGIIGIFLPLLPTTPFVLLSAACWAKASPRFYRWLHRHRYFGPMV|||||||| |||||||||||||||||||||||||||||||||||:||||||||||||| g624MIRYLLIACGGISLLLGIIGIFLPLLPTTPFVLLSAACWAKASPRFHRWLHRHRYFGPMV        10        20        30        40        50        60        70        80        90       100       110       120 m624.pepHNWEQNGAVPRKAKIFAISMMTASCLIMFWQFPQRWWVGAVSSVFCSLVAIWMWRRPESX||||||||||||||||||||:|||||::||:||| ||||||||||||||:| ||:||||| g624HNWEQNGAVPRKAKIFAISMITASCLMIFWHFPQXWWVGAVSSVFCSLVTIRMWHRPESX        70        80        90       100       110       120The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2001>:

a624.seq 1 ATGATACGTT ATCTTTTAAT TGCCTGCGGC TGCATTTCCC TGCTGTTGGG 51TATCATCGGC ATTTTTTTGC CGCTGTTGCC GACCACGCCG TTCGTACTGC 101 TCTCCGCCGCCTGCTGGGCA AAGGCATCCC CGCGCTTTCA CCGCTGGCTG 151 CACCGGCACC GCTATTTCGGTCCGATGGTT CATAACTGGG AACAAAACGG 201 CGCAGTGCCG CGCAAAGCCA AAATATTCGCCATCAGTATG ATGACCGCAT 251 CCTGCCTGAT AATGTTTTGG CAGTTTCCCC AACGCTGGTGGGTCGGGGCG 301 GTTTCATCGG TTTTTTGTTC CCTTGTCGCC ATATGGATGT GGCGCAGGCC351 CGAATCTTGAThis corresponds to the amino acid sequence <SEQ ID 2002; ORF 624.a>:

a624.pep 1 MIRYLLIACG CISLLLGIIG IFLPLLPTTP FVLLSAACWA KASPRFHRWL 51HRHRYFGPMV HNWEQNGAVP RKAKIFAISM MTASCLIMFW QFPQRWWVGA 101VSSVFCSLVA IWMWRRPES* m624/a624 99.2% identity in 119 aa overlap        10        20        30        40        50        60 m624.pepMIRYLLIACGCISLLLGIIGIFLPLLPTTPFVLLSAACWAKASPRFYRWLHRHRYFGPMV||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||| a624MIRYLLIACGCISLLLGIIGIFLPLLPTTPFVLLSAACWAKASPRFHRWLHRHRYFGPMV        10        20        30        40        50        60        70        80        90       100       110       120 m624.pepHNWEQNGAVPRKAKIFAISMMTASCLIMFWQFPQRWWVGAVSSVFCSLVAIWMWRRPESX|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a624HNWEQNGAVPRKAKIFAISMMTASCLIMFWQFPQRWWVGAVSSVFCSLVAIWMWRRPESX        70        80        90       100       110       120The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2003>:

a625.seq 1 ATGTTTGCAA CCAGGAAAAT GAAGAAGATG ACGATGTGCA CGCGGCGGGT 51ACGGTTTTGG TTGGCTTTCA GCAGCGGACG AATCATCAGC ATTGCTGCGC 101 CGGTCGTTCCCATGATAGAG GCAAGTGCCG TACCGACGGC AAGCAGGGCG 151 GTGTTGAGCT TGGGTGTGCCGTTCAAGTCG CCCCAAACCA AAATGCCGCC 201 TGAAATGGTG TACAGGGCAA GCAGCAGCAGGATGAAAGGG ATGTATTCTT 251 CAACGAGTGC GTGTGCGACG GTATGGATAC CGGCGGACGCGCCAAAAACC 301 AAACTGAACG GGATGAGGAA GAGCAATGTC CAAAAGGCGG TAATTTTGCC351 GTAAThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2004>:

g625.seq 1 atGTTTGCAA CCAGGAAAAT GAAGAAGATG ACGATGTGCA CGCGGCGGGT 51ACGGtcTTGG TTGGCTTTCA GCAGCGGACG AATCATCAGC AttgCCGCGC 101 CGGtcgttcCCATGATAGAG GCAAGTGCCG TACCGACGGC AAGCAGGGCG 151 GTGTTGAGCT TGGGTGTGCCGTTCAAGTCG CCCCAAACCA AAATGCCGCC 201 TGAAATGGTG TACAGGGCAA GCAGCAGCAGGATGAAGGGG ATATATTCTT 251 CAACGAGTGC GTGTGCGACG GTATGGATAC CGGCGGACGCGCCAAAAACC 301 AAACTGAACG GGATGAGGAA GAGCAATGTC CAAAAGGCGG TGATTTTGCc351 gtAAThis corresponds to the amino acid sequence <SEQ ID 2005; ORF 625.ng>:

g625.pep 1 MFATRKMKKM TMCTRRVRSW LAFSSGRIIS IAAPVVPMIE ASAVPTASRA 51VLSLGVPFKS PQTKMPPEMV YRASSSRMKG IYSSTSACAT VWIPADAPKT 101 KLNGMRKSNVQKAVILP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2006>:

m625.seq 1 ATGTTTGCAA CCAGGAAAAT GAAGAAGATG ACGATGTGCA CGCGGCGGGT 51ACGGTTTTGG TTGGCTTTCA GCAGCGGACG AATCATCAGC ATTGCTGCGC 101 CGGTCGTTCCCATGATAGAG GCAAGTGCCG TACCGACGGC AAGCAGGGCG 151 GTGTTGAGCT TGGGTGTGCCGTTCAAGTCG CCCCAAACCA AAATGCCGCC 201 TGAAATGGTG TACAGGGCAA GCAGCAGCAGGATGAAAGGG ATGTATTCTT 251 CAACGAGTGC GTGTGCGACG GTATGGATAC CGGCGGACGCGCCAAAAACC 301 AAACTGAACG GGATGAGGAA GAGCAATGTC CAAAAGGCGG TAATTTTGCC351 GTAAThis corresponds to the amino acid sequence <SEQ ID 2007; ORF 625>:

m625.pep 1 MFATRKMKKM TMCTRRVRFW LAFSSGRIIS IAAPVVPMIE ASAVPTASRA 51VLSLGVPFKS PQTKMPPEMV YRASSSRMKG MYSSTSACAT VWIPADAPKT 101 KLNGMRKSNVQKAVILP* m625/g625 98.3% identity in 117 aa overlap        10        20        30        40        50        60 m625.pepMFATRKMKKMTMCTRRVRFWLAFSSGRIISIAAPVVPMIEASAVPTASRAVLSLGVPFKS|||||||||||||||||| ||||||||||||||||||||||||||||||||||||||||| g625MFATRKMKKMTMCTRRVRSWLAFSSGRIISIAAPVVPMIEASAVPTASRAVLSLGVPFKS        10        20        30        40        50        60        70        80        90       100       110 m625.pepPQTKMPPEMVYRASSSRMKGMYSSTSACATVWIPADAPKTKLNGMRKSNVQKAVILPX||||||||||||||||||||:||||||||||||||||||||||||||||||||||||| g625PQTKMPPEMVYRASSSRMKGIYSSTSACATVWIPADAPKTKLNGMRKSNVQKAVILPX        70        80        90       100       110This corresponds to the amino acid sequence <SEQ ID 2008; ORF 625.a>:

a625.pep 1 MFATRKMKKM TMCTRRVRFW LAFSSGRIIS IAAPVVPMIE ASAVPTASRA 51VLSLGVPFKS PQTKMPPEMV YRASSSRMKG MYSSTSACAT VWIPADAPKT 101KLNGMRKSNV QKAVILP* m625/a625 100.0% identity in 117 aa overlap        10        20        30        40        50        60 m625.pepMFATRKMKKMTMCTRRVRFWLAFSSGRIISIAAPVVPMIEASAVPTASRAVLSLGVPFKS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a625MFATRKMKKMTMCTRRVRFWLAFSSGRIISIAAPVVPMIEASAVPTASRAVLSLGVPFKS        10        20        30        40        50        60        70        80        90       100       110 m625.pepPQTKMPPEMVYRASSSRMKGMYSSTSACATVWIPADAPKTKLNGMRKSNVQKAVILPX|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a625PQTKMPPEMVYRASSSRMKGMYSSTSACATVWIPADAPKTKLNGMRKSNVQKAVILPX        70        80        90       100       110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2009>:

g627.seq 1 ATGTCCGGCC TTTGGAAACC CGAACACCCG GGATTTGAAA TCCTCGGCAG 51CCGTTACGCC CTGCAAAACC TTGTCCGCGA TGTCATCCTG ATTACATTGA 101CCGCCGTATC TATGGCAATC ACGCCCAAAC AAGTCCGCGC AGGCAACGAA 151TTCAACTTTG AACCCATCGC CGAAGTGGGC AAACTCTTCC TCGGCATCTT 201CATCACCATC TTCCCCGTCC TGAGCATTCT GAAAGCAGGC GAGGCAGGCG 251CGCTGGGCGG GGTGGTATCG CTGGTTCACG ATACGGCAGG TCATCCGATT 301AATACGATGT ATTTCTGGAT GAGCGGCATA TTGTCGGCAT TCTTGGATAA 351CGCGCCCACT TATCTCGTGT TTTTCAATAT GGCGGGCGGC GATGCCCAAG 401CCTTAATGAC GGGTCCCCTG TTTCATTcgc TGCTGGCGGT TTCTAtgggT 451tCGGTATTCA TGGGCGCACT GaccTACATc gGCAAcgcac cgaactTCAT 501GGTcaaggcc aTTGCCGaaC agcgcgGCgt accgaTGCcg actTTCTTcc 551ggtaTAtgat gtggtcggtc gcCTTCCTGa caCCCGTCTT CAtcgTACAT 601ACCCTcgtCT TTTTcgTTtt cAAACTACTg taaThis corresponds to the amino acid sequence <SEQ ID 2010: ORF 627.ng>:

g627.pep 1 MSGLWKPEHP GFEILGSRYA LQNLVRDVIL ITLTAVSMAI TPKQVRAGNE 51FNFEPIAEVG KLFLGIFITI FPVLSILKAG EAGALGGVVS LVHDTAGHPI 101NTMYFWMSGI LSAFLDNAPT YLVFFNMAGG DAQALMTGPL FHSLLAVSMG 151SVFMGALTYI GNAPNFMVKA IAEQRGVPMP TFFRYMMWSV AFLTPVFIVH 201 TLVFFVFKLL *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2011>:

m627.seq 1 ATGTCCGGCC TTTGGAAACC CGAACACCCG GGATTTGAAA TCCTCGGCAG 51CCGTTACGCC CTGCAAAACC TCGTCCGCGA TGTCATCCTG ATTGCATTGA 101CCGCCGTATC TATGGCAATC ACGCCCAAAC AAGTCCGCGC AGGCAACGAA 151TTCAACTTTG AACCCATCGC CGAAGTGGGC AAACTCTTCC TCGGCATCTT 201CATCACCATC TTTCCCGTCC TGAGCATTCT GAAAGCAGGC GAGGCAGGCG 251CGCTGGGCGG GGTGGTATCG CTGGTTCACG ATACGGCAGG TCATCCGATT 301AATGTGATGT ATTTTTGGAT GAGCGGCATA TTGTCGGCAT TCTTGGATAA 351CGCGCCCACT TATCTCGTTT TTTTCAATAT GGCGGGCGGC GATGCCCAAG 401CCTTGATGAC GGGTACCCTG TTTCATTCGC TGCTGGCGGT TTCTATGGGT 451TCGGTATTCA TGGGCGCACT GACCTACATC GGCAACGCAC CGAACTTCAT 501GGTCAAGGCC ATTGCCGAAC AGCGCGGCGT ACCGATGCCG ACTTTCTTCG 551GCTATATGAT GTGGTCGGTC GCCTTCCTGA CACCCGTCTT CATCGTACAT 601ACCCTTATCT TTTTCGTTTT CAAACTGCTG TAAThis corresponds to the amino acid sequence <SEQ ID 2012; ORF 627>:

m627.pep 1 MSGLWKPEHP GFEILGSRYA LQNLVRDVIL IALTAVSMAI TPKQVRAGNE 51FNFEPIAEVG KLFLGIFITI FPVLSILKAG EAGALGGVVS LVHDTAGHPI 101NVMYFWMSGI LSAFLDNAPT YLVFFNMAGG DAQALMTGTL FHSLLAVSMG 151SVFMGALTYI GNAPNFMVKA IAEQRGVPMP TFFGYMMWSV AFLTPVFIVH 201 TLIFFVFKLL *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m627/g627 97.6% identity in 210 aa overlap        10        20        30        40        50        60 m627.pepMSGLWKPEHPGFEILGSRYALQNLVRDVILIALTAVSMAITPKQVRAGNEFNFEPIAEVG|||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||| g627MSGLWKPEHPGFEILGSRYALQNLVRDVILITLTAVSMAITPKQVRAGNEFNFEPIAEVG        10        20        30        40        50        60        70        80        90       100       110       120 m627.pepKLFLGIFITIFPVLSILKAGEAGALGGVVSLVHDTAGHPINVMYFWMSGILSAFLDNAPT|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| g627KLFLGIFITIFPVLSILKAGEAGALGGVVSLVHDTAGHPINTMYFWMSGILSAFLDNAPT        70        80        90       100       110       120       130       140       150       160       170       180 m627.pepYLVFFNMAGGDAQALMTGTLFHSLLAVSMGSVFMGALTYIGNAPNFMVKAIAEQRGVPMP|||||||||||||||||| ||||||||||||||||||||||||||||||||||||||||| g627YLVFFNMAGGDAQALMTGPLFHSLLAVSMGSVFMGALTYIGNAPNFMVKAIAEQRGVPMP       130       140       150       160       170       180       190       200       210 m627.pep TFFGYMMWSVAFLTPVFIVHTLIFFVFKLLX||| ||||||||||||||||||:|||||||| g627 IFFRYMMWSVAFLTPVFIVHILVFFVFKLLX       190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2013>:

a627.seq 1 ATGTCCGGCC TTTGGAAACC CGAACACCCG GGATTTGAAA TCCTCGGCAG 51CCGTTACGCC CTGCAAAACC TCGTCCGCGA TGTCATCCTG ATTGCATTGA 101CCGCCGTATC TATGGCAATC ACGCCCAAAC AAGTCCGCGC AGGCAACGAA 151TTCAACTTTG AACCCATCGC CGAAGTGGGC AAACTCTTCC TCGGCATCTT 201CATCACCATC TTTCCCGTCC TGAGCATTCT GAAAGCAGGC GAGGCAGGCG 251CGCTGGGCGG GGTGGTATCG CTGGTTCACG ATACGGCAGG TCATCCGATT 301AATGTGATGT ATTTTTGGAT GAGCGGCATA TTGTCGGCAT TCTTGGATAA 351CGCGCCCACT TATCTCGTTT TTTTCAATAT GGCGGGCGGC GATGCCCAAG 401CCTTGATGAC GGGTTCCCTG TTTCATTCGC TGCTGGCGGT TTCTATGGGT 451TCGGTATTCA TGGGCGCACT GACCTACATC GGCAACGCAC CGAACTTCAT 501GGTCAAGGCC ATTGCCGAAC AGCGCGGCGT ACCGATGCCG ACTTTCTTCG 551GCTATATGAT GTGGTCGGTC GCCTTCCTGA CACCCGTCTT CATCGTACAT 601ACCCTTATCT TTTTCGTTTT CAAACTGCTG TAAThis corresponds to the amino acid sequence <SEQ ID 2014; ORF 627.a>:

a627.pep 1 MSGLWKPEHP GFEILGSRYA LQNLVRDVIL IALTAVSMAI TPKQVRAGNE 51FNFEPIAEVG KLFLGIFITI FPVLSILKAG EAGALGGVVS LVHDTAGHPI 101NVMYFWMSGI LSAFLDNAPT YLVFFNMAGG DAQALMTGSL FHSLLAVSMG 151SVFMGALTYI GNAPNFMVKA IAEQRGVPMP TFFGYMMWSV AFLTPVFIVH 201 TLIFFVFKLL *m627/a627 99.5% identity in 210 aa overlap        10        20        30        40        50        60 m627.pepMSGLWKPEHPGFEILGSRYALQNLVRDVILIALTAVSMAITPKQVRAGNEFNFEPIAEVG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a627MSGLWKPEHPGFEILGSRYALQNLVRDVILIALTAVSMAITPKQVRAGNEFNFEPIAEVG        10        20        30        40        50        60        70        80        90       100       110       120 m627.pepKLFLGIFITIFPVLSILKAGEAGALGGVVSLVHDTAGHPINVMYFWMSGILSAFLDNAPT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a627KLFLGIFITIFPVLSILKAGEAGALGGVVSLVHDTAGHPINVMYFWMSGILSAFLDNAPT        70        80        90       100       110       120       130       140       150       160       170       180 m627.pepYLVFFNMAGGDAQALMTGTLFHSLLAVSMGSVFMGALTYIGNAPNFMVKAIAEQRGVPMP||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||| a627YLVFFNMAGGDAQALMTGSLFHSLLAVSMGSVFMGALTYIGNAPNFMVKAIAEQRGVPMP       130       140       150       160       170       180       190       200       210 m627.pep TFFGYMMWSVAFLTPVFIVHTLIFFVFKLLX||||||||||||||||||||||||||||||| a627 TFFGYMMWSVAFLTPVFIVHTLIFFVFKLLX       190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2015>:

g628.seq 1 ATGTGCGTGC CACTCAAGCC GGCAGGATGC GGGCCGCCAA ATTCATGTGT 51TTCGATATTG GCAGCATTTT CAGACGGCAC GTCTGCGCCT GCTGCTTTAC 101ACACATGGAT TTTACGTTCG GTCAGGCGGC TCAATACCAA CAGGCCGCGT 151TTGAAGTCTT CGGCGGCTTC TTTGATGATG ACCGTAGGGT CGGCAGCCAG 201CGGATTGGTG TCCATCGCAT TGACGAAGAT GGCGAACGGC TCGGCATCTA 251CGGCAGGGAT TTTGCTGAAC GGACGGGTGC GAAGCGCAGT CCATAAGCCT 301GATTGAATCA GGTTGCGGCG CACTTTTTCG CTGCTCAATT TTGCCAGCGC 351TTCAGGTacg TAGThis corresponds to the amino acid sequence <SEQ ID 2016; ORF 628.ng>:

g628.pep 1 MCVPLKPAGC GPPNSCVSIL AAFSDGTSAP AALHTWILRS VRRLNTNRPR 51LKSSAASLMM TVGSAASGLV SIALTKMANG SASTAGILLN GRVRSAVHKP 101D*IRLRRTFS LLNFASASGT *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2017>:

m628.seq 1 ATGTGCGTGC CACTCAAACC GGCAGGATGC GGGCCGCCGA ATTCATGTGT 51TTCGATGTTG GCAGCATTTT CAGACGGCAC GTCTGCGCCA GCTGCCTTAC 101AAACATGGAT TTTGCGTTCG GTCAAACGGC TCAATACCAA CAGGCCGCGT 151TTGAAATCCT CGGCGGCTTC TTTGATAATG ACCGTAGGGT CGGCAGCCAG 201CGGATTGGTG TCCATCGCAT TGACGAAGAT GGCGAACGGC TCGGCATCGA 251CGGCAGGAAT TTTGCTGAAC GGACGGGTGC GCAGCGCAGT CCACAAACCG 301GATTGGATCA GGTTGCGGCG CACTTCTTCG CCGCTTAAGT TTGCCAGCGC 351TTCAGGTGCG TAGThis corresponds to the amino acid sequence <SEQ ID 2018: ORF 628>:

m628.pep 1 MCVPLKPAGC GPPNSCVSML AAFSDGTSAP AALQTWILRS VKRLNTNRPR 51LKSSAASLIM TVGSAASGLV SIALTKMANG SASTAGILLN GRVRSAVHKP 101DWIRLRRTSS PLKFASASGA *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m628/g628 93.3% identity in 119 aa overlap        10        20        30        40        50        60 m628.pepMCVPLKPAGCGPPNSCVSMLAAFSDGTSAPAALQTWILRSVKRLNTNRPRLKSSAASLIM||||||||||||||||||:||||||||||||||:|||||||:||||||||||||||||:| g628MCVPLKPAGCGPPNSCVSILAAFSDGTSAPAALHTWILRSVRRLNTNRPRLKSSAASLMM        10        20        30        40        50        60        70        80        90       100       110       120 m628.pepTVGSAASGLVSIALTKMANGSASTAGILLNGRVRSAVHKPDWIRLRRTSSPLKFASASGA||||||||||||||||||||||||||||||||||||||||| |||||| | |:||||||: g628TVGSAASGLVSIALTKMANGSASTAGILLNGRVRSAVHKPDXIRLRRIFSLLNFASASGT        70        80        90       100       110       120 m628.pep Xg628 XThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2019>:

a628.seq 1 ATGTGCGTGC CACTCAAACC GGCCGGATGC GGGCCGCCGA ATTCATGTGT 51TTCGATGTTG GCAGCATTTT CAGACGGCAC GTCTGCGCCA GCTGCCTTAC 101ACACATGGAT TTTACGCTCG GTCAAACGGC TCAATACCAG CAAACCTCGT 151CTGAAATCCT CGGCGGCTTC TTTGATCACA ACCACAGGGT CTGCCGCCAG 201CGGATTGGTG TCCATCGCAT TGACGAAGAT GGCGAACGGC TCGGCATCGA 251CGGCAGGGAT TTTGCTGAAC GGACGGGTAC GCAGCGCAGT CCACAAACCG 301GATTGGATCA GATTGCGGCG CACTTCTTCG CCGCTTAAGT TTGCCAACGC 351TTCGGGCGCG TAGThis corresponds to the amino acid sequence <SEQ ID 2020; ORF 628.a>:

a628.pep 1 MCVPLKPAGC GPPNSCVSML AAFSDGTSAP AALHTWILRS VKRLNTSKPR 51LKSSAASLIT TTGSAASGLV SIALTKMANG SASTAGILLN GRVRSAVHKP 101DWIRLRRTSS PLKFANASGA * m628/a628 95.0% identity in 120 aa overlap        10        20        30        40        50        60 m628.pepMCVPLKPAGCGPPNSCVSMLAAFSDGTSAPAALQTWILRSVKRLNTNRPRLKSSAASLIM|||||||||||||||||||||||||||||||||:||||||||||||::||||||||||| a628MCVPLKPAGCGPPNSCVSMLAAFSDGTSAPAALHTWILRSVKRLNTSKPRLKSSAASLIT        10        20        30        40        50        60        70        80        90       100       110       120 m628.pepTVGSAASGLVSIALTKMANGSASTAGILLNGRVRSAVHKPDWIRLRRTSSPLKFASASGA|:|||||||||||||||||||||||||||||||||||||||||||||||||||||:|||| a628TTGSAASGLVSIALTKMANGSASTAGILLNGRVRSAVHKPDWIRLRRTSSPLKFANASGA        70        80        90       100       110       120 m628.pep X| a628 XThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2021>:

g629.seq 1 ATGACTGCca aacCTTTTTC CCTCAACCTG GCcaaCCTCC TGCTGCCggc 51ggtatTGTTT GCCGTCAGcc tGtcggTCGG cattgccgaT TTCCGCTGGT 101 CGGATGTGTTTTCGCTGTCC GACAGCCAGC AAGTGATGTT CATCAGCCGC 151 CTGCCGCGCA CGTTTGcgaTTGTGTTGACG GGCgcgtcga tagcgGtggc 201 gGGGAtgatt atgcagATTC TGATGCGCAACcgtTTTGTC GAGCCTtcta 251 tggcgGGTGC GGGCCAAAGt gcgGCTTTGG GTttgcttctgAtgtccctg 301 ctgctgcctg CcgcGccgct gccggtcaAA ATGTCGGtag Ccgccgttgc351 CGCGCTGATC GGGATGTTGG tctTtatgct gctaatccgC Cgcctgccac 401cgacggcgca gctgatgGTg ccgCTGGTGG Gg.ttATTTT CGGCGGCGTG 451 GttgaGGCGGTGGCGACGTT TGTCGCGTAT GAGTTTGAGA TGCTGCAAAT 501 GTTGGGCGTG TGGCAGCAGGGCGACTTTTC AAGCGTGCTG CTGGGGCGGT 551 ACGAGCTGCT TTGGATTACG GGCGGTTTGGCGGTGTTTGC CTACCTGATT 601 GCCGACCGGC TGACGATTTT GGGGCTGGGC GAGACGGTGAGCGTGAATTT 651 GGGTTTGAAC CGGACGGCGG TGTTGTGGTC GGGTTTGATT ATTGTGGCAC701 TGATTACATC GCTGGTCATT GTAACGGTCG GCAATATTCC GTTTATCGGG 751CTGGTCGTGC CGAATATCGT CAGCCGCCTG ATGGGCGACA GGCTGCGCCA 801 AAGCCTGCCTGCGGTCGCCC TCTTGGGCGC GTCTTTGGTT TTATTGTGCG 851 ACATTATCGG ACGCATGATTGTGTTTCCGT TTGAAATTCC GGTCTCCACG 901 GTTTTTGGTG TGTTGGGTAC GGCTTTGTTTTTGTGGCTTT TGTTGAGGAA 951 ACCCGCCTAT GCCGTCTGAThis corresponds to the amino acid sequence <SEQ ID 2022; ORF 629.ng>:

g629.pep 1 MTAKPFSLNL ANLLLPAVLF AVSLSVGIAD FRWSDVFSLS DSQQVMFISR 51LPRTFAIVLT GASIAVAGMI MQILMRNRFV EPSMAGAGQS AALGLLLMSL 101 LLPAAPLPVKMSVAAVAALI GMLVFMLLIR RLPPTAQLMV PLVGXIFGGV 151 VEAVATFVAY EFEMLQMLGVWQQGDFSSVL LGRYELLWIT GGLAVFAYLI 201 ADRLTILGLG ETVSVNLGLNRTAVLWSGLI IVALITSLVI VTVGNIPFIG 251 LVVPNIVSRLMGDRLRQSLP AVALLGASLV LLCDIIGRMI VFPFEIPVST 301 VFGVLGTALF LWLLLRKPAYAV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2023>:

m629.seq 1 ATGACTGCCA AACCTTTTTC CCTCAACCTG ACCAACCTGC TGCTGCTGGC 51GGTGTTGTTT GCCGTCAGCC TGTCGGTGGG CGTTGCCGAT TTCCGCTGGT 101 CTGATGTGTTTTCACTGTCC GACAGCCAGC AGGTCATGTT CATCAGCCGC 151 CTGCCGCGCA CGTTTGCGATTGTGCTGACG GGCGCGTCGA TGGCGGTGGC 201 CGGCATGATT ATGCAGATTT TGATGCGCAACCGTTTTGTC GAACCGTCGA 251 TGGTGGGCGC AAGCCAAAGC GCGGCTTTAG GTTTGCTGCTGATGACCCTG 301 CTGCTGCCGG CCGCGCCGCT GCCGGCGAAA ATGTCGGTTG CCGCCGTTGC351 CGCGCTGATC GGGATGTTGG TCTTTATGCT GCTGATCCGC CGCCTGCCGC 401CGACCGCGCA ACTGATGGTG CCTTTGGTCG GGATTATTTT CGGCGGTGTG 451 ATTGAGGCGGTAGCCACCTT TATCGCGTAT GAAAACGAAA TGCTGCAAAT 501 GCTCGGCGTG TGGCAGCAGGGCGATTTTTC GAGCGTGCTG CTGGGGCGGT 551 ACGAGCTGCT TTGGATTACG GGCGGTTTGGCGGTGTTTGC CTATCTGATT 601 GCCGACCGGC TGACGATTTT GGGGCTGGGC GAAACGGTAAGCGTGAATTT 651 GGGTTTGAAC CGGACGGCGG TGTTGTGGTC GGGTTTGATT ATTGTGGCTT701 TGATTACGTC GCTGGTTATC GTTACGGTCG GCAATATTCC GTTTATCGGG 751CTGGTCGTGC CGAACATCAT CAGCCGCCTG ATGGGCGACA GGTTGCGCCA 801 AAGCCTGCCTGCGGTGGCCT TGCTGGGCGC ATCTTTGGTG TTGCTGTGCG 851 ACATTATCGG ACGCGTGATTGTGTTTCCGT TTGAAATTCC GGTCTCTACG 901 GTTTTTGGTG TATTGGGTAC GGCTTTGTTTTTGTGGCTTT TGTTGAGGAA 951 ACCCGCCTAT GCCGTCTGAThis corresponds to the amino acid sequence <SEQ ID 2024; ORF 629>:

m629.pep 1 MTAKPFSLNL TNLLLLAVLF AVSLSVGVAD FRWSDVFSLS DSQQVMFISR 51LPRTFAIVLT GASMAVAGMI MQILMRNRFV EPSMVGASQS AALGLLLMTL 101 LLPAAPLPAKMSVAAVAALI GMLVFMLLIR RLPPTAQLMV PLVGIIFGGV 151 IEAVATFIAY ENEMLQMLGVWQQGDFSSVL LGRYELLWIT GGLAVFAYLI 201 ADRLTILGLG ETVSVNLGLNRTAVLWSGLI IVALITSLVI VTVGNIPFIG 251 LVVPNIISRLMGDRLRQSLP AVALLGASLV LLCDIIGRVI VFPFEIPVST 301 VFGVLGTALF LWLLLRKPAYAV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m629/g629 95.7% identity in 322 aa overlap        10        20        30        40        50        60 m629.pepMTAKPFSLNLTNLLLLAVLFAVSLSVGVADFRWSDVFSLSDSQQVMFISRLPRTFAIVLT||||||||||:|||| |||||||||||:|||||||||||||||||||||||||||||||| g629MTAKPFSLNLANLLLPAVLFAVSLSVGIADFRWSDVFSLSDSQQVMFISRLPRTFAIVLT        10        20        30        40        50        60        70        80        90       100       110       120 m629.pepGASMAVAGMIMQILMRNRFVEPSMVGASQSAALGLLLMTLLLPAAPLPAKMSVAAVAALI|||:||||||||||||||||||||:||:||||||||||:|||||||||:||||||||||| g629GASIAVAGMIMQILMRNRFVEPSMAGAGQSAALGLLLMSLLLPAAPLPVKMSVAAVAALI        70        80        90       100       110       120       130       140       150       160       170       180 m629.pepGMLVFMLLIRRLPPTAQLMVPLVGIIFGGVIEAVATFIAYENEMLQMLGVWQQGDFSSVL|||||||||||||||||||||||| |||||: ||||||:||| |||||||||||||||||| g629GMLVFMLLIRRLPPTAQLMVPLVGXIFGGVVEAVATFVAYEFEMLQMLGVWQQGDFSSVL       130       140       150       160       170       180       190       200       210       220       230       240 m629.pepLGRYELLWITGGLAVFAYLIADRLTILGLGETVSVNLGLNRTAVLWSGLIIVALITSLVI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g629LGRYELLWITGGLAVFAYLIADRLTILGLGETVSVNLGLNRTAVLWSGLIIVALITSLVI       190       200       210       220       230       240       250       260       270       280       290       300 m629.pepVTVGNIPFIGLVVPNIISRLMGDRLRQSLPAVALLGASLVLLCDIIGRVIVFPFEIPVST||||||||||||||||:|||||||||||||||||||||||||||||||:||||||||||| g629VTVGNIPFIGLVVPNIVSRLMGDRLRQSLPAVALLGASLVLLCDIIGRMIVFPFEIPVST       250       260       270       280       290       300       310       320 m629.pep VFGVLGTALFLWLLLRKPAYAVX||||||||||||||||||||||| g629 VFGVLGTALFLWLLLRKPAYAVX       310       320The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2025>:

a629.seq 1 ATGACTGCCA AACCTTTTTC CCTCAACCTG ACTAACCTCC TGCTGCTGGC 51GGTGTTGTTT GCCGTCAGCC TGTCGGTGGG CGTTGCCGAT TTCCGCTGGT 101 CGGATGTGTTTTCGCTGTCG GACAGCCAGC AGGTTATGTT CATCAGCCGC 151 CTGCCGCGCA CGTTTGCGATTGTGTTGACG GGCGCGTCGA TGGCGGTGGC 201 GGGGATGATT ATGCAGATTC TGATGCGTAACCGTTTTGTC GAGCCTTCTA 251 TGGCGGGCGC GGGTCAGAGT GCGGCTTTGG GTTTGCTTCTGATGTCCCTG 301 CTGCTGCCTG CCGCGCCGCT GCCGGTCAAA ATGTCGGTTG CCGCCGTTGC351 CGCGTTAATC GGGATGTTGG TGTTTATGAT GCTTATCCGC CGCCTGCCGC 401CGACGGCGCA ACTGATGGTG CCTTTGGTCG GGATTATTTT CGGCGGCGTG 451 GTTGAGGCGGTGGCCACCTT TATTGCGTAT GAAAACGAAA TGCTGCAAAT 501 GCTGGGCGTG TGGCAACAGGGCGATTTTTC CGGCGTGTTG CTCGGACGGT 551 ATGAACTGTT GTGGGCAACG GGGATTTTGGCTTTGTTTGC CTATTTGATT 601 GCCGACCAGC TGACGATTTT GGGTTTGGGC GAAACGGTAAGCGTGAACTT 651 GGGGCTGAAC CGGACGGCGA TTCTGTGGTC GGGGCTGATT ATTGTGGCTT701 TGATTACGTC GCTGGTTATC GTTACGGTCG GCAATATTCC GTTTATCGGG 751CTGGTCGTGC CGAACATCAT CAGCCGCCTG ATAGGCGACA GGCTGCGCCA 801 AAGCCTGCCTGCGGTGGCTT TGCTGGGTGC GTCTTTGGTT TTATTGTGCG 851 ACATTATCGG ACGAGTGATTGTGTTTCCGT TTGAAATTCC GGTATCGACC 901 GTCTTCGGCG TATTGGGTAC GGCGTTGTTTTTATGGCTTT TGTTAAGGAA 951 ACCTGCTCAT GCCGTCTGAThis corresponds to the amino acid sequence <SEQ ID 2026; ORF 629.a>:

a629.pep 1 MTAKPFSLNL TNLLLLAVLF AVSLSVGVAD FRWSDVFSLS DSQQVMFISR 51LPRTFAIVLT GASMAVAGMI MQILMRNRFV EPSMAGAGQS AALGLLLMSL 101 LLPAAPLPVKMSVAAVAALI GMLVFMMLIR RLPPTAQLMV PLVGIIFGGV 151 VEAVATFIAY ENEMLQMLGVWQQGDFSGVL LGRYELLWAT GILALFAYLI 201 ADQLTILGLG ETVSVNLGLNRTAILWSGLI IVALITSLVI VTVGNIPFIG 251 LVVPNIISRL IGDRLRQSLPAVALLGASLV LLCDIIGRVI VFPFEIPVST 301 VFGVLGTALF LWLLLRKPAH AV* m629/a62995.7% identity in 322 aa overlap        10        20        30        40        50        60 m629.pepMTAKPFSLNLNLLLLAVLFAVSLSVGVADFRWSDVFSLSDSQQVMFISRLPRTFAIVLT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a629MTAKPFSLNLTNLLLLAVLFAVSLSVGVADFRWSDVFSLSDSQQVMFISRLPRTFAIVLT        10        20        30        40        50        60        70        80        90       100       110       120 m629.pepGASMAVAGMIMQILMRNRFVEPSMVGASQSAALGLLLMTLLLPAAPLPAKMSVAAVAALI||||||||||||||||||||||||:||:||||||||||:|||||||||:||||||||||| a629GASMAVAGMIMQILMRNRFVEPSMAGAGQSAALGLLLMSLLLPAAPLPVKMSVAAVAALI        70        80        90       100       110       120       130       140       150       160       170       180 m629.pepGMLVFMLLIRRLPPTAQLMVPLVGIIFGGVIEAVATFIAYENEMLQMLGVWQQGDFSSVL||||||:|||||||||||||||||||||||:||||||||||||||||||||||||||:|| a629GMLVFMMLIRRLPPTAQLMVPLVGIIFGGVVEAVATFIAYENEMLQMLGVWQQGDFSGVL       130       140       150       160       170       180       190       200       210       220       230       240 m629.pepLGRYELLWITGGLAVFAYLIADRLTILGLGETVSVNLGLNRTAVLWSGLIIVALITSLVI|||||||| || ||:|||||||:||||||||||||||||||||:|||||||||||||||| a629LGRYELLWATGILALFAYLIADQLTILGLGETVSVNLGLNRTAILWSGLIIVALITSLVI       190       200       210       220       230       240       250       260       270       280       290       300 m629.pepVTVGNIPFIGLVVPNIISRLMGDRLRQSLPAVALLGASLVLLCDIIGRVIVFPFEIPVST||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||| a629VTVGNIPFIGLVVPNIISRLIGDRLRQSLPAVALLGASLVLLCDIIGRVIVFPFEIPVST       250       260       270       280       290       300       310       320 m629.pep VFGVLGTALFLWLLLRKPAYAVX|||||||||||||||||||:||| a629 VFGVLGTALFLWLLLRKPAHAVX       310       320The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2027>:

g630.seq (partial) 1 aTgatGATTT TGGTGTGGCT ggctttgttt ccccccatgttttacggcat 51 gtacaacgtc GGCGCACAGG CATTCGGTGC CTTAACGCCC GAtttgctgc 101aacaaagcat cgcccacgac ggcaattacg ccctcgccaa cgctttgggc 151 atcaatatgtcccccgaaGc gggcgtgtTg ggcaaaatgc tgttcgGCGC 201 GATttacttc ctgccgatttacgcgaccgt aTTTATTGTG GGcggcttct 251 ggGaagtCTT GTTCGCATCc gtACGCAAACACGAAATCAA CGAAGGTTTC 301 TTCGTTACTT CGATTCTGTT TGCCTTAATC GTTCCGCCCACGCTGCCGCT 351 GTGGCAGGCG GCTTTGGGTA TTTCTTTCGG CGTTGTGGTT GCGAAAGAAG401 TATTCGGCGG TACAGGTAAA AACTTCATGA ACCCTGCGCT GGCAGGCCGC 451GCCTTCCTGT TCTTCGCCTA CCCCGCCAAC TTGAGCGGCG ATGCGGTTTG 501 GACGGCGGTTGACGGCTATT CCGGCGCAAC CGCGCTGGCG CAATGGGCGG 551 CACACGGTGC AGACGGCCTGAAAAACGCCG TAACCGGTCA AACCATCACT 601 TGGATGGACG CGTTTATCGG CAAACTGCCCGGCTCCATCG GCGAAGTCTC 651 CACTTTGGCA CTCTTAATCG GCGGCGCGTT TATCGTGTTTGCCCGCATCG 701 CTtcttgGCG CATTATTGCc ggCGTGATGA TCGGTatGat tGcgatgTCT751 tcgctgatta acttcatCGg ttctgacacc aaagctatgt ttgctatgca 801cttggtacat ggcacttggt GGAaagatGa ttAtcactca ctgtacatta 851 aa.....This corresponds to the amino acid sequence <SEQ ID 2028; ORF 630.ng>:

g630.pep 1 MMILVWLALF PPMFYGMYNV GAQAFGALTP DLLQQSIAHD GNYALANALG 51INMSPEAGVL GKMLFGAIYF LPIYATVFIV GGFWEVLFAS VRKHEINEGF 101FVTSILFALI VPPTLPLWQA ALGISFGVVV AKEVFGGTGK NFMNPALAGR 151 AFLFFAYPANLSGDAVWTAV DGYSGATALA QWAAHGADGL KNAVTGQTIT 201 WMDAFIGKLPGSIGEVSTLA LLIGGAFIVF ARIASWRIIA GVMIGMIAMS 251 SLINFIGSDT KAMFAMHLVHGTWWKDDYHS LYIK....The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2029>:

m630.seq 1 ATGATGATTT TGGTGTGGCT GGCTTTGTTC CCTGCCATGT TCTACGGTAT 51GTACAACGTC GGCGCGCAGG CATTCGGTGC GTTAACGCCT GATTTGCTGC 101 AACAAAACATCGCCAACGAC TGGCATTACG CCTTTGCCAA CGCTTTGGGC 151 ATCAATATGT CGTCTGAAGCGGGCGTGTCG GACAAAATGC TGTTTGGCGC 201 GATTTACTTC CTGCCGATTT ACGCGACTGTATTTGTTGTG GGCGGTTTCT 251 GGGAAGTTTT GTTCGCCACC GTGCGCAAAC ACGAAATCAACGAAGGTTTC 301 TTCGTTACTT CGATTCTGTT TGCCTTAATC GTTCCGCCCA CGCTGCCGCT351 GTGGCAGGCG GCTTTGGGTA TTTCTTTCGG CGTTGTGGTT GCGAAAGAAG 401TATTCGGCGG TACAGGTAAA AACTTCATGA ACCCTGCGCT GGCAGGCCGT 451 GCTTTCCTGTTCTTCGCCTA CCCTGCCAAC TTGAGCGGCG ATGCGGTTTG 501 GACGGCGGTT GACGGCTATTCCGGCGCAAC CGCACTGGCG CAATGGGCGG 551 CACACGGTGC AGACGGCCTG AAAAACGCCGTAACCGGTCA AACCATCACT 601 TGGATGGACG CGTTTATCGG CAAACTGCCC GGCTCCATTGGCGAAGTCTC 651 CACTTTGGCA CTCTTAATCG GCGGCGCGTT TATCGTGTTT GCCCGCATCG701 CTTCTTGGCG CATTATTGCC GGCGTGATGA TCGGTATGAT TGCGATGTCT 751TCGCTGTTCA ACTTCATCGG TTCGGACACC AACGCTATGT TTGCTATGCC 801 TTGGTACTGGCACTTGGTGG TCGGCGGCTT CGCCATCGGT ATGCTGTTTA 851 TGGCGACCGA CCCTGTTTCCGCTTCCTTTA CCAATGTCGG CAAATGGTGG 901 TACGGCGCAC TGATCGGTGT GATGTGCGTATTAATCCGCG TGGTCAATCC 951 GGCTTACCCC GAAGGCATGA TGTTGGCGAT TCTGTTTGCCAACCTGTTTG 1001 CCCCGATTTT CGACTATTTC GTCGCACAAG CGAACATCAA ACGCAGAAAG1051 GCGCGCAGCA ATGGCTAAThis corresponds to the amino acid sequence <SEQ ID 2030; ORF 630>:

m630.pep 1 MMILVWLALF PAMFYGMYNV GAQAFGALTP DLLQQNIAND WHYAFANALG 51INMSSEAGVS DKMLFGAIYF LPIYATVFVV GGFWEVLFAT VRKHEINEGF 101FVTSILFALI VPPTLPLWQA ALGISFGVVV AKEVFGGTGK NFMNPALAGR 151 AFLFFAYPANLSGDAVWTAV DGYSGATALA QWAAHGADGL KNAVTGQTIT 201 WMDAFIGKLPGSIGEVSTLA LLIGGAFIVF ARIASWRIIA GVMIGMIAMS 251 SLFNFIGSDTNAMFAMPWYW HLVVGGFAIG MLFMATDPVS ASFTNVGKWW 301 YGALIGVMCV LIRVVNPAYPEGMMLAILFA NLFAPIFDYF VAQANIKRRK 351 ARSNG* m630/g630 93.5% identity in275 aa overlap        10        20        30        40        50        60 m630.pepMMILVWLALFPAMFYGMYNVGAQAFGALTPDLLQQNIANDWHYAFANALGINMSSEAGVS||||||||||| |||||||||||||||||||||||:||:|:| ||:||||||||| |||| g630MMILVWLALFPPMFYGMYNVGAQAFGALTPDLLQQSIAHDGNYALANALGINMSPEAGVL        10        20        30        40        50        60        70        80        90       100       110       120 m630.pepDKMLFGAIYFLPIYATVFVVGGFWEVLFATVRKHEINEGFFVTSILFALIVPPTLPLWQA |||||||||||||||||:||||||||||:|||||||||||||||||||||||||||||| g630GKMLFGAIYFLPIYATVFIVGGFWEVLFASVRKHEINEGFFVTSILFALIVPPTLPLWQA        70        80        90       100       110       120       130       140       150       160       170       180 m630.pepALGISFGVVVAKEVFGGTGKNFMNPALAGRAFLFFAYPANLSGDAVWTAVDGYSGATALA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g630ALGISFGVVVAKEVFGGTGKNFMNPALAGRAFLFFAYPANLSGDAVWTAVDGYSGATALA       130       140       150       160       170       180       190       200       210       220       230       240 m630.pepQWAAHGADGLKNAVTGQTITWMDAFIGKLPGSIGEVSTLALLIGGAFIVFARIASWRIIA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g630QWAAHGADGLKNAVTGQTITWMDAFIGKLPGSIGEVSTLALLIGGAFIVFARIASWRIIA       190       200       210       220       230       240       250       260       270       280       290       300 m630.pepGVMIGMIAMSSLFNFIGSDTNAMFAMPWYWHLVVGGFAIGMLFMATDPVSASFTNVGKWW||||||||||||:|||||||:|||||    ||| | g630GVMIGMIAMSSLINFIGSDTKAMFAM----HLVHGTWWKDDYHSLYIK.       250       260           270       280       310       320       330       340       350 m630.pepYGALIGVMCVLIRVVNPAYPEGMMLAILFANLFAPIFDYFVAQANIKRRKARSNGXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2031>:

a630.seq 1 ATGATGATTT TGGTGTGGCT GGCTTTGTTC CCTGCCATGT TCTACGGTAT 51GTACAACGTC GGCGCACAGG CATTCGGTGC GTTAACGCCC GATTTGCTGC 101 AACAAAGCATCGCCAACGAC TGGCATTACG CCCTTGCCAA CGCTTTGGGC 151 ATCAATATGT CGTCTGAAGCGGGCGTGTTG GGCAAAATGC TGTTCGGCGC 201 GATTTACTTC CTGCCGATTT ACGCGACCGTATTTATTGTC GGCGGTTTCT 251 GGGAAGTTTT GTTCGCCACC GTGCGCAAAC ATGAAATCAACGAAGGTTTC 301 TTTGTTACCT CGATTCTGTT TGCCTTAATC GTTCCGCCCA CGCTGCCGCT351 GTGGCAGGCA GCTTTGGGTA TTTCTTTCGG CGTTGTGGTT GCGAAAGAAG 401TATTCGGCGG TACAGGTAAA AACTTCATGA ACCCTGCGCT GGCAGGCCGT 451 GCCTTCCTGTTCTTCGCCTA CCCTGCCAAC TTGAGCGGCG ATGCGGTTTG 501 GACGGCGGTT GACGGCTATTCCGGCGCAAC CGCGCTGGCG CAATGGGCGG 551 CACACGGTGC AGACGGCCTG AAAAACGCCATAACCGGTCA AACCATCACT 601 TGGATGGATG CGTTTATCGG CAAACTGCCC GGCTCCATCGGCGAAGTCTC 651 CACTTTGGCA CTCTTAATCG GCGGCGCGTT TATCGTGTTT GCCCGCATCG701 CTTCTTGGCG CATTATTGCC GGCGTGATGA TCGGTATGAT TGCCATGTCT 751TCGCTGTTCA ACTTCATCGG TTCGGACACC AACGCTATGT TTGCTATGCC 801 TTGGTACTGGCATTTGGTCG TCGGCGGCTT CGCCATCGGT ATGCTGTTTA 851 TGGCGACCGA CCCCGTTTCCGCTTCCTTTA CCAATGTCGG CAAATGGTGG 901 TACGGCGCAC TGATCGGTGT GATGTGCGTATTAATCCGCG TGGTCAATCC 951 GGCTTACCCC GAAGGCATGA TGTTGGCGAT TCTGTTTGCCAACCTGTTTG 1001 CCCCGATTTT CGACTATTTC GTCGCACAAG CGAACATCAA ACGCAGAAAG1051 GCGCGCAGCA ATGGCTAAThis corresponds to the amino acid sequence <SEQ ID 2032; ORF 630.a>:

a630.pep 1 MMILVWLALF PAMFYGMYNV GAQAFGALTP DLLQQSIAND WHYALANALG 51INMSSEAGVL GKMLFGAIYF LPIYATVFIV GGFWEVLFAT VRKHEINEGF 101FVTSILFALI VPPTLPLWQA ALGISFGVVV AKEVFGGTGK NFMNPALAGR 151 AFLFFAYPANLSGDAVWTAV DGYSGATALA QWAAHGADGL KNAITGQTIT 201 WMDAFIGKLPGSIGEVSTLA LLIGGAFIVF ARIASWRIIA GVMIGMIAMS 251 SLFNFIGSDTNAMFAMPWYW HLVVGGFAIG MLFMATDPVS ASFTNVGKWW 301 YGALIGVMCV LIRVVNPAYPEGMMLAILFA NLFAPIFDYF VAQANIKRRK 351 ARSNG* m630/a630 98.3% identity in355 aa overlap        10        20        30        40        50        60 m630.pepMMILVWLALFPAMFYGMYNVGAQAFGALTPDLLQQNIANDWHYAFANALGINMSSEAGVS|||||||||||||||||||||||||||||||||||:||||||||:|||||||||||||| a630MMILVWLALFPAMFYGMYNVGAQAFGALTPDLLQQSIANDWHYALANALGINMSSEAGVL        10        20        30        40        50        60        70        80        90       100       110       120 m630.pepDKMLFGAIYFLPIYATVFVVGGFWEVLFATVRKHEINEGFFVTSILFALIVPPTLPLWQA |||||||||||||||||:||||||||||||||||||||||||||||||||||||||||| a630GKMLFGAIYFLPIYATVFIVGGFWEVLFATVRKHEINEGFFVTSILFALIVPPTLPLWQA        70        80        90       100       110       120       130       140       150       160       170       180 m630.pepALGISFGVVVAKEVFGGTGKNFMNPALAGRAFLFFAYPANLSGDAVWTAVDGYSGATALA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a630ALGISFGVVVAKEVFGGTGKNFMNPALAGRAFLFFAYPANLSGDAVWTAVDGYSGATALA       130       140       150       160       170       180       190       200       210       220       230       240 m630.pepQWAAHGADGLKNAVTGQTITWMDAFIGKLPGSIGEVSTLALLIGGAFIVFARIASWRIIA|||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||| a630QWAAHGADGLKNAITGQTITWMDAFIGKLPGSIGEVSTLALLIGGAFIVFARIASWRIIA       190       200       210       220       230       240       250       260       270       280       290       300 m630.pepGVMIGMIAMSSLFNFIGSDTNAMFAMPWYWHLVVGGFAIGMLFMATDPVSASFTNVGKWW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a630GVMIGMIAMSSLFNFIGSDTNAMFAMPWYWHLVVGGFAIGMLFMATDPVSASFTNVGKWW       250       260       270       280       290       300       310       320       330       340       350 m630.pepYGALIGVMCVLIRVVNPAYPEGMMLAILFANLFAPIFDYFVAQANIKRRKARSNGX|||||||||||||||||||||||||||||||||||||||||||||||||||||||| a630YGALIGVMCVLIRVVNPAYPEGMMLAILFANLFAPIFDYFVAQANIKRRKARSNGX       310       320       330       340       350The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2033>:

g635.seq 1 ATGACCCGGC GACGGGTCGG CAAGCAAAAC CGTATTGCCA TCCACTCCGC 51GCAATACCGA AAAATGGTCG TCTTTGCGGT ATTTCAGATA CACGATGACG 101 GGGATTTTCAACTGCGCGAG CTGTTCGAAA GACAGGGCAT AGCCTTTCGC 151 CTCAAAACCC AAATCGGGCATAATGCGCCG CATATCCTCA AACGACGCGC 201 GCATCTGTTC CTTACCCAGT TTTTCCAACACTTCTTCTTC CGTCAGCTTT 251 TGCCCGTAAA AATTGTTCAA AAGCGTCGCC ACCGAAGCCGCCCCGCAGGA 301 AAAATCCAAA TCCTGCTTTA CAATATTGAA ATCCCGCCGC GCTTTCCAAC351 TCTGCAATTT GATTTTTCCG TAAACAACAG GATTATCGTT AAACATCGGT 401GCAGCATTCA AACGATAAGA CAAGGGTCTG TACCAGATTA GThis corresponds to the amino acid sequence <SEQ ID 2034; ORF 635.ng>:

g635.pep 1 MTRRRVGKQN RIAIHSAQYR KMVVFAVFQI HDDGDFQLRE LFERQGIAFR 51LKTQIGHNAP HILKRRAHLF LTQFFQHFFF RQLLPVKIVQ KRRHRSRPAG 101 KIQILLYNIEIPPRFPTLQF DFSVNNRIIV KHRCSIQTIR QGSVPD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2035>:

m635.seq 1 ATGACCCAGC GACGGGTCGG CAAGCAAAAC CGTATTGCCG TCTATACCGC 51GCAATACCGA GAAATGATCA TCCTTGCGGT ATTTCAGATA CACGATGACG 101 GGGATTTGCAACTGTGCAAG CTGCTCGAAA GACAGGGCAT AGCCTTTCGC 151 TTCAAAACCC AAATCAGGCATAATGCGCCG CATATCCTCA AACGACGCGG 201 GCATCTGCTC CTTATCCAGT TTTTTTAACACGTCCTCTTC CGTCAGCTTT 251 TGCCCGTAAA AATTGTTCAA AAGCGTCACC ACCGAAGCCGCCCCGCAGGA 301 AAAATCCAAA TCCTGCTTTA CAATATTGAA ATCGCGCCTT TCTTTCCAAC351 TCTGCACTTT GATTTTTCCA TAAGCAACAG GATTATAGTG GATTAAThis corresponds to the amino acid sequence <SEQ ID 2036; ORF 635>:

m635.pep 1 MTQRRVGKQN RIAVYTAQYR EMIILAVFQI HDDGDLQLCK LLERQGIAFR 51FKTQIRHNAP HILKRRGHLL LIQFF*HVLF RQLLPVKIVQ KRHHRSRPAG 101 KIQILLYNIEIAPFFPTLHF DFSISNRIIV D* m635/g635 80.0% identity in 130 aa overlap        10        20        30        40        50        60 m635.pepMTQRRVGKQNRIAVYTAQYREMIILAVFQIHDDGDLQLCKLLERQGIAFRFKTQIRHNAP||:||||||||||:::||||:|:::||||||||||:|| :|:||||||||:|||| |||| g635MTRRRVGKQNRIAIHSAQYRKMVVFAVFQIHDDGDFQLRELFERQGIAFRLKTQIGHNAP        10        20        30        40        50        60        70        80        90       100       110       120 m635.pepHILKRRGHLLLIQFFXHVLFRQLLPVKIVQKRHHRSRPAGKIQILLYNIEIAPFFPTLHF||||||:||:| ||| | :|||||||||||||:|||||||||||||||||| | ||||:| g635HILKRRAHLFLTQFFQHFFFRQLLPVKIVQKRRHRSRPAGKIQILLYNIEIPPRFPTLQF        70        80        90       100       110       120        130m635.pep DFSISNRIIVDX |||::||||| g635 DFSVNNRIIVKHRCSIQTIRQGSVPDX       130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2037>:

a635.seq 1 ATGACCCAGC GACGGGTCGG CAAGCAAAAC CGTATTGCCG TCTATACCGC 51GCAATACCGA GAAATGATCA TCCTTGCGGT ATTTCAGATA CACGATGACG 101 GGGATTTGCAACTGTGCAAG CTGCTCGAAA GACAGGGCAT AGCCTTTCGC 151 CTCAAAACCC AAATCAGGCATGATGCGCCG CATATCCTCA AACGACGCGC 201 GCATCTGCTC CTTATCCAGC TTTTTCAACACGTCCTCTTC CGTCAGCTTT 251 TGCCCGTGAA AATTGTTCAA AAGCGTCGCC ACCGAAGCCGCCCCGCAGGA 301 AAAATCCAAA TCCTGCTTTA CAATATTGAA ATCGCGCCTT TCTTTCCAAC351 TCTGCACTTT GATTTTTCCA TAAGCAACAG GATTATAGTG GATTAAThis corresponds to the amino acid sequence <SEQ ID 2038; ORF 635.a>:

a635.pep 1 MTQRRVGKQN RIAVYTAQYR EMIILAVFQI HDDGDLQLCK LLERQGIAFR 51LKTQIRHDAP HILKRRAHLL LIQLFQHVLF RQLLPVKIVQ KRRHRSRPAG 101 KIQILLYNIEIAPFFPTLHF DFSISNRIIV D* m635/a635 95.4% identity in 131 aa overlap        10        20        30        40        50        60 m635.pepMTQRRVGKQNRIAVYTAQYREMIILAVFQIHDDGDLQLCKLLERQGIAFRFKTQIRHNAP||||||||||||||||||||||||||||||||||||||||||||||||||:||||||:|| a635MTQRRVGKQNRIAVYTAQYREMIILAVFQIHDDGDLQLCKLLERQGIAFRLKTQIRHDAP        10        20        30        40        50        60        70        80        90       100       110       120 m635.pepHILKRRGHLLLIQFFXHVLFRQLLPVKIVQKRHHRSRPAGKIQILLYNIEIAPFFPTLHF||||||:||||||:| ||||||||||||||||:||||||||||||||||||||||||||| a635HILKRRAHLLLIQLFQHVLFRQLLPVKIVQKRRHRSRPAGKIQILLYNIEIAPFFPTLHF        70        80        90       100       110       120        130m635.pep DFSISNRIIVDX |||||||||||| a635 DFSISNRIIVDX        130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2039>:

g638.seq 1 ATGATTGGCG GACAGTTTAT CGTAGttgGc atTGTAGGCA AAAACGCACT 51TGCCCGCTTT GTTGATAATA ttgtcGTGAA TAtcGGAATA GTTGACATAG 101 TTGAGCATGATGCCCTAATC GCGGCTGCCG ACGGCGATAT TGTCGAACAC 151 TTTGAGCCGT TCGGAAAACATCAGCACATA GCCCATATTG TtgcCCACGG 201 AAATATTGCC GCTGacttcg ctgtcgTTGGTGTACATATA GTGGACGGCG 251 AAACGCAGGT CGCTGAAGCG GTTGTTTTTA TAGGTGTTGTGCGTGCTGGT 301 ATTGGAAAAA ATGCCGTCCC GCCCTTTGGA AATGTCGTTG ccgACGACCT351 GCGCgccggg CgcgtTCCAA ACGGTAACGC CATTGCCGCG CTCATTCACG 401CGCAAGGTcg catcgCCGAC GATTTTATTC TCGCGCACCA TCGCATCGGC 451 AGAACCATGAAGGTATACGC CGAACGAATT ATCAAAAATA TTGTTGTGTT 501 CAACCAGGGC GCGCGGGGCGGCTTTTTCGA GATAAATACC GGCATCCATT 551 GCTGGCAGGC TCATACCGGA ACGGGTAACGGTCAGGTTGC GGAGCGTTAC 601 GTCCGGCGCG TGTACGGCTA TGGTACGCCC GCTCTTGTCCCCTTCGATGG 651 TTGCGGAACG GTCGGCAGGC CCTTCAATCG TAATCGGTTT GTCGATATAA701 AGTTTGGTTT GATATACGCC GGAAGCCAGT TTGATCGTAT CGCCCGCCCG 751GGCGCGGGCA AAAATTTCGG CAAGGTTGTC TTGCGGGGAA ACGTGGACGA 801 CGGCTGCCGATGCCGTCTGA AAAATGCTGC CGGCGGCAAG TATCAGCACG 851 GCCTTCAGCC ATATACGGAGCGCGGATGTG TGCATAGTGT CCCTCTGTTT 901 CGTTCGGTAT GGCCGAACAA AATAAAGCATCATTCAAATG TGCCTGTTTT 951 TATAGCGAAA CCGCCTGAAA CGGTACGGCA AGCGGTTTGGCTATAAThis corresponds to the amino acid sequence <SEQ ID 2040; ORF 638.ng>:

g638.pep 1 MIGGQFIVVG IVGKNALARF VDNIVVNIGI VDIVEHDALI AAADGDIVEH 51FEPFGKHQHI AHIVAHGNIA ADFAVVGVHI VDGETQVAEA VVFIGVVRAG 101 IGKNAVPPFGNVVADDLRAG RVPNGNAIAA LIHAQGRIAD DFILAHHRIG 151 RTMKVYAERI IKNIVVFNQGARGGFFEINT GIHCWQAHTG TGNGQVAERY 201 VRRVYGYGTP ALVPFDGCGT VGRPFNRNRFVDIKFGLIYA GSQFDRIARP 251 GAGKNFGKVV LRGNVDDGCR CRLKNAAGGK YQHGLQPYTERGCVHSVPLF 301 RSVWPNKIKH HSNVPVFIAK PPETVRQAVW L*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2041>:

m638.seq 1 ATGATTGGCG AAAAGTTTAT CGTAGTTGGC ATTATAGGCA AATACGCACT 51TGCCTGCCTT GTTGATAATG TTGTCGTGAA TATCGGAATA GTTGACATAG 101 TTGAGCATAATGCCCTGATC GCGGCTGCCG ACGGCGATAT TGTCGAATAC 151 TTTGAGCCGC TCGGAAAACATCAGCACATA GCCCATATTG TTGCCCACGG 201 AAATATTGCC GCTGATTTCG CTGTCGTTGGTGTACATATA GTGGACGGCG 251 AAACGCAAAT CGCTGAAGCG GTTGTTTTTG TAGGTGTTGTGCGTGCTGGT 301 ATTGGAAAAA ATGCCGTCCC GCCCTTTGGA AATGTCGTTG CCGACGACCT351 GCGCACCGGG TGCGTTCCAA ACGGTAACGC CGTTGCCGCG CTCGTTCACG 401CGCAAAGTCG CGTCGCCGAC GATTTTATTC TCGCGCACCA TCGCATCGGC 451 AGAACCATGCAGATATACGC CGACCGAATT ATCCAAAATA TTGTTGTGTT 501 CAATCAGGGC GCGCGGGGCAGTTTCTTCGA GATAAATACC GGCATCCATT 551 GCGGGCAGGC TCATACCGGA ACGGGTAACGGTCAGGTTGC GGAGCGTTAC 601 GTCCGGCGCG TGTACGGCTA TGGTACGCCC GCTCCTGTCGCCTTCGATGG 651 TTGCGGAACG GTCGGCAGGC CCTTCAATCG TAATCGGTTT GTCAATGTGA701 AGTTTGGTTT TATATACGCC GGAAGCCAGT TTGAGCGTAT CGCCCGCCCG 751GGCGCGGGCA AATGCGGGAT ACCGATCAGC ATAATCGGTT CGTGAThis corresponds to the amino acid sequence <SEQ ID 2042; ORF 638>:

m638.pep 1 MIGEKFIVVG IIGKYALACL VDNVVVNIGI VDIVEHNALI AAADGDIVEY 51FEPLGKHQHI AHIVAHGNIA ADFAVVGVHI VDGETQIAEA VVFVGVVRAG 101 IGKNAVPPFGNVVADDLRTG CVPNGNAVAA LVHAQSRVAD DFILAHHRIG 151 RTMQIYADRI IQNIVVFNQGARGSFFEINT GIHCGQAHTG TGNGQVAERY 201 VRRVYGYGTP APVAFDGCGT VGRPFNRNRFVNVKFGFIYA GSQFERIARP 251 GAGKCGIPIS IIGS* m638/g638 88.2% identity in254 aa overlap        10        20        30        40        50        60 m638.pepMIGEKFIVVGIIGKYALACLVDNVVVNIGIVDIVEHNALIAAADGDIVEYFEPLGKHQHI||| :||||||:|| ||| :|||:||||||||||||:||||||||||||:|||:|||||| g638MIGGQFIVVGIVGKNALARFVDNIVVNIGIVDIVEHDALIAAADGDIVEHFEPFGKHQHI        10        20        30        40        50        60        70        80        90       100       110       120 m638.pepAHIVAHGNIAADFAVVGVHIVDGETQIAEAVVFVGVVRAGIGKNAVPPFGNVVADDLRTG||||||||||||||||||||||||||:||||||:||||||||||||||||||||||||:| g638AHIVAHGNIAADFAVVGVHIVDGETQVAEAVVFIGVVRAGIGKNAVPPFGNVVADDLRAG        70        80        90       100       110       120       130       140       150       160       170       180 m638.pepCVPNGNAVAALVHAQSRVADDFILAHHRIGRTMQIYADRIIQNIVVFNQGARGSFFEINT|||||||:|||:|||:|:|||||||||||||||::||:|||:|||||||||||:|||||| g638RVPNGNAIAALIHAQGRIADDFILAHHRIGRTMKVYAERIIKNIVVFNQGARGGFFEINT       130       140       150       160       170       180       190       200       210       220       230       240 m638.pepGIHCGQAHTGTGNGQVAERYVRRVYGYGTPAPVAFDGCGTVGRPFNRNRFVNVKFGFIYA|||| |||||||||||||||||||||||||| | |||||||||||||||||::|||:||| g638GIHCWQAHTGTGNGQVAERYVRRVYGYGTPALVPFDGCGTVGRPFNRNRFVDIKFGLIYA       190       200       210       220       230       240       250       260 m638.pep GSQFERIARPGAGKCGIPISIIGSX ||||:|||||||||g638 GSQFDRIARPGAGKNFGKVVLRGNVDDGCRCRLKNAAGGKYQHGLQPYTERGCVHSVPLF       250       260       270       280       290       300The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2043>:

a638.seq 1 ATGATTGGCG GACAGTTTAT CGTAGTTGGC ATTGTAGGCA AAAACGCACT 51TGCCCGCTTT GTTGATAATG TTGTCGTGAA TATCGGAATA GTTGACATAG 101 TTGAGCATGATGCCTTGGTC GCGGCTGCCG ACGGCGATAT TGTCAAACAC 151 TTTGAGCCGC TCGGAAAACATCAGCACATA GCCCATATTG TTGCCCACGG 201 AAATATTGCC GCTGATTTCG CTGTCGTTGGTGTACATATA GTGGACGGCG 251 AAACGCAAAT CGCTGAAGCG GTTGTTTTTA TAGGTGTTGTGCGTGCTGGT 301 ATTGGAAAAA ATGCCGTCCC GCCCTTTGGA AATATCGTTG CCGACGACCT351 GCGCGCCGGG CGCGTTCCAA ACGGTAACGC CATTGCCGCG CTCGTTCACG 401CGCAAAGTCG CGTCGCCGAC GATTTTATTC TCCCGCACCA TCGCATCGGC 451 AGAACCATGCAGATAGACGC CGACCGAATT ATCCAAAATA TTATTGTGTT 501 CAATCAGGGC GCGCGGGGCAGTTTCTTCGA GATAAATACC GGCATCCATT 551 GCGGGCAGGC TCATACCGGA ACGGGTAACGGTCAGGTTGC GGAGCGTTAC 601 GTCCGGCGCG TGTACGGCTA TGGTACGCCC GCTCCTGTCTCCTTCGATGG 651 TTGCAGAACG GTCGGCAGGC CCTTCAATCG TAATCGGTTT GTCGATGTGA701 AGTTTGGTTT GATATACGCC GGAAGCCAGT TTGAGCGTAT CGCCCGCCCG 751GGCGCGGGCA AATGCGGGAT ACCGATCAGC ATAATCGACT CATGGTGAThis corresponds to the amino acid sequence <SEQ ID 2044; ORF 638.a>:

a638.pep 1 MIGGQFIVVG IVGKNALARF VDNVVVNIGI VDIVEHDALV AAADGDIVKH 51FEPLGKHQHI AHIVAHGNIA ADFAVVGVHI VDGETQIAEA VVFIGVVRAG 101 IGKNAVPPFGNIVADDLRAG RVPNGNAIAA LVHAQSRVAD DFILPHHRIG 151 RTMQIDADRI IQNIIVFNQGARGSFFEINT GIHCGQAHTG TGNGQVAERY 201 VRRVYGYGTP APVSFDGCRT VGRPFNRNRFVDVKFGLIYA GSQFERIARP 251 GAGKCGIPIS IIDSW* m638/a638 91.3% identity in264 aa overlap        10        20        30        40        50        60 m638.pepMIGEKFIVVGIIGKYALACLVDNVVVNIGIVDIVEHNALIAAADGDIVEYFEPLGKHQHI||| :||||||:|| ||| :||||||||||||||||:||:||||||||::|||||||||| a638MIGGQFIVVGIVGKNALARFVDNVVVNIGIVDIVEHDALVAAADGDIVKHFEPLGKHQHI        10        20        30        40        50        60        70        80        90       100       110       120 m638.pepAHIVAHGNIAADFAVVGVHIVDGETQIAEAVVFVGVVRAGIGKNAVPPFGNVVADDLRTG|||||||||||||||||||||||||||||||||:|||||||||||||||||:||||||:| a638AHIVAHGNIAADFAVVGVHIVDGETQIAEAVVFIGVVRAGIGKNAVPPFGNIVADDLRAG        70        80        90       100       110       120       130       140       150       160       170       180 m638.pepCVPNGNAVAALVHAQSRVADDFILAHHRIGRTMQIYADRIIQNIVVFNQGARGSFFEINT||||||:|||||||||||||||| |||||||||| ||||||||:||||||||||||||| a638RVPNGNAIAALVHAQSRVADDFILPHHRIGRTMQIDADRIIQNIIVFNQGARGSFFEINT       130       140       150       160       170       180       190       200       210       220       230       240 m638.pepGIHCGQAHTGTGNGQVAERYVRRVYGYGTPAPVAFDGCGTVGRPFNRNRFVNVKFGFIYA|||||||||||||||||||||||||||||||||:|||| ||||||||||||:||||:||| a638GIHCGQAHTGTGNGQVAERYVRRVYGYGTPAPVSFDGCRTVGRPFNRNRFVDVKFGLIYA       190       200       210       220       230       240       250       260 m638.pep GSQFERIARPGAGKCGIPISIIGSX|||||||||||||||||||||| | a638 GSQFERIARPGAGKCGIPISIIDSWX       250       260The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2045>:

g639-1.seq 1 ATGAGCCTGC CAGCAATGGA TGCCGGTATT TATCTCGAAA AAGCCGCCCC 51GCGCGCCCTG GTTGAACACA ACAATATTTT TGATAATTCG TTCGGCGTAT 101 ACCTTCATGGTTCTGCCGAT GCGATGGTGC GCGAGAATAA AATCGTCGGC 151 GATGCGACCT TGCGCGTGAATGAGCGCGGC AATGGCGTTA CCGTTTGGAA 201 CGCGCCCGGC GCGCAGGTCG TCGGCAACGACATTTCCAAA GGGCGGGACG 251 GCATTTTTTC CAATACCAGC ACGCACAACA CCTATAAAAACAACCGCTTC 301 AGCGACCTGC GTTTCGCCGT CCACTATATG TACACCAACG ACAGCGAAGT351 CAGCGGCAAT ATTTCCGTGG GCAACAATAT GGGCTATGTG CTGATGTTTT 401CCGAACGGCT CAAAGTGTTC GACAATATCG CCGTCGGCAG CCGCGATTAG 451 GGCATCATGCTCAACTATGT CAACTATTCC GATATTCACG ACAATATTAT 501 CAACAAAGCG GGCAAGTGCGTTTTTGCCTA CAATGCCAAC TACGATAAAC 551 TGTCCGCCAA TCATTTTGAA AACTGCCAAATCGGCATGCA CTTTACCGCC 601 GCCATCGAAG GCACGTCCCT GCACGACAAT TCCTTTATCAACAACGGAAG 651 CCAGGTCAAA TATGTCAGTA CGCGCTTTCT CGACTGGAGC GAGGGCGGAC701 ACGGCAACTA CTGGAGCGAC AACAGCCCGT TCGATTTGAA CGGCGACGGC 751TTCGGAGACA GCGCGTACCG TCCCGACGGC ATCATCGACC AAATCATCTG 801 GCGCGCGCCCGTATCGCGCC TCTTGATGAA CAGTCCCGCA ATCAGCATCG 851 TCAAATGGGC GCAGGCGCAGTTTCCCGCCG TTCTGCCCGG CGGCGTGGTG 901 GACAGCAAAC CGCTGATGAA GCCTTATGCCCCCAAAATTC AAACCCGTTA 951 TCAGGCGATG AAGGACGAGT TGCTCAAAGA AGCCGAAACGCGGCAGTCGG 1001 AACGGGGCAG GGCGGAAAAC GGTTCTTTGA ACTAGThis corresponds to the amino acid sequence <SEQ ID 2046; ORF 639-1.ng>:

g639-1.pep 1 MSLPAMDAGI YLEKAAPRAL VEHNNIFDNS FGVYLHGSAD AMVRENKIVG 51DATLRVNERG NGVTVWNAPG AQVVGNDISK GRDGIFSNTS THNTYKNNRF 101 SDLRFAVHYMYTNDSEVSGN ISVGNNMGYV LMFSERLKVF DNIAVGSRD* 151 GIMLNYVNYS DIHDNIINKAGKCVFAYNAN YDKLSANHFE NCQIGMHFTA 201 AIEGTSLHDN SFINNGSQVK YVSTRFLDWSEGGHGNYWSD NSPFDLNGDG 251 FGDSAYRPDG IIDQIIWRAP VSRLLMNSPA ISIVKWAQAQFPAVLPGGVV 301 DSKPLMKPYA PKIQTRYQAM KDELLKEAET RQSERGRAEN GSLN*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2047>:

m639-1.seq 1 ATGAGCCTGC CCGCAATGGA TGCCGGTATT TATCTCGAAG AAACTGCCCC 51GCGCGCCCTG ATTGAACACA ACAATATTTT GGATAATTCG GTCGGCGTAT 101 ATCTGCATGGTTCTGCCGAT GCGATGGTGC GCGAGAATAA AATCGTCGGC 151 GACGCGACTT TGCGCGTGAACGAGCGCGGC AACGGCGTTA CCGTTTGGAA 201 CGCACCCGGT GCGCAGGTCG TCGGCAACGACATTTCCAAA GGGCGGGACG 251 GCATTTTTTC CAATACCAGC ACGCACAACA CCTACAAAAACAACCGCTTC 301 AGCGATTTGC GTTTCGCCGT CCACTATATG TACACCAACG ACAGCGAAAT351 CAGCGGCAAT ATTTCCGTGG GCAACAATAT GGGCTATGTG CTGATGTTTT 401CCGAGCGGCT CAAAGTATTC GACAATATCG CCGTCGGCAG CCGCGATCAG 451 GGCATTATGCTCAACTATGT CAACTATTCC GATATTCACG ACAACATTAT 501 CAACAAGGCA GGCAAGTGCGTATTTGCCTA TAATGCCAAC TACGATAAAC 551 TTTTCGCCAA TCATTTTGAA AACTGTCAAATCGGCATACA CTTTACCGCC 601 GCCATCGAAG GCACGTCCTT GCATGACAAT TCCTTTATCAACAACGAAAG 651 CCAGGTCAAA TACGTCAGCA CGCGCTTTCT CGATTGGAGC GAGGGCGGAC701 ACGGCAACTA TTGGAGCGAC AACAGCGCGT TCGATTTGAA CGGCGACGGC 751TTCGGAGACA GCGCGTACCG CCCCAACGGC ATCATCGACC AAATCATCTG 801 GCGCGCGCCCGTATCGCGCC TTTTGATGAA CAGTCCCGCA ATCAGCATCG 851 TCAAATGGGC GCAGGCGCAGTTTCCCGCCG TTCTGCCTGG CGGCGTGGTG 901 GACAGCAAAC CGCTGATGAA GCCTTATGCCCCCAAAATTC AAACCCGTTA 951 TCAGGCGATG AAGGACGAGC TACTCAAAGA AGTCGAAACGCGGCAGTCGG 1001 AATGGGGCAG GGCGGAAAAC GGTTCTTTGA ACTAGThis corresponds to the amino acid sequence <SEQ ID 2048; ORF 639-1>:

m639-1.pep 1 MSLPAMDAGI YLEETAPRAL IEHNNILDNS VGVYLHGSAD AMVRENKIVG 51DATLRVNERG NGVTVWNAPG AQVVGNDISK GRDGIFSNTS THNTYKNNRF 101 SDLRFAVHYMYTNDSEISGN ISVGNNMGYV LMFSERLKVF DNIAVGSRDQ 151 GIMLNYVNYS DIHDNIINKAGKCVFAYNAN YDKLFANHFE NCQIGIHFTA 201 AIEGTSLHDN SFINNESQVK YVSTRFLDWSEGGHGNYWSD NSAFDLNGDG 251 FGDSAYRPNG IIDQIIWRAP VSRLLMNSPA ISIVKWAQAQFPAVLPGGVV 301 DSKPLMKPYA PKIQTRYQAM KDELLKEVET RQSEWGRAEN GSLN*g639-1/m639-1 95.9% identity in 344 aa overlap        10        20        30        40        50        60 g639-1.pepMSLPAMDAGIYLEKAAPRALVEHNNIFDNSFGVYLHGSADAMVRENKIVGDATLRVNERG|||||||||||||::|||||:|||||:||| ||||||||||||||||||||||||||||| m639-1MSLPAMDAGIYLEETAPRALIEHNNILDNSVGVYLHGSADAMVRENKIVGDATLRVNERG        10        20        30        40        50        60        70        80        90       100       110       120 g639-1.pepNGVTVWNAPGAQVVGNDISKGRDGIFSNTSTHNTYKNNRFSDLRFAVHYMYTNDSEVSGN||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||| m639-1NGVTVWNAPGAQVVGNDISKGRDGIFSNTSTHNTYKNNRFSDLRFAVHYMYTNDSEISGN        70        80        90       100       110       120       130       140       150       160       170       180 g639-1.pepISVGNNMGYVLMFSERLKVFDNIAVGSRDXGIMLNYVNYSDIHDNIINKAGKCVFAYNAN||||||||||||||||||||||||||||| |||||||||||||||||||||||||||||| m639-1ISVGNNMGYVLMFSERLKVFDNIAVGSRDQGIMLNYVNYSDIHDNIINKAGKCVFAYNAN       130       140       150       160       170       180       190       200       210       220       230       240 g639-1.pepYDKLSANHFENCQIGMHFLAAIEGTSLHDNSFINNGSQVKYVSTRFLDWSEGGHGNYWSD|||| ||||||||||:||||||||||||||||||| |||||||||||||||||||||||| m639-1YDKLFANHFENCQIGIHFLAAIEGTSLHDNSFINNESQVKYVSTRFLDWSEGGHGNYWSD       190       200       210       220       230       240       250       260       270       280       290       300 g639-1.pepNSPFDLNGDGFGDSAYRPDGIIDQIIWRAPVSRLLMNSPAISIVKWAQAQFPAVLPGGVV|| |||||||||||||||:||||||||||||||||||||||||||||||||||||||||| m639-1NSAFDLNGDGFGDSAYRPNGIIDQIIWRAPVSRLLMNSPAISIVKWAQAQFPAVLPGGVV       250       260       270       280       290       300       310       320       330       340 g639-1.pepDSKPLMKPYAPKIQTRYQAMKDELLKEAETRQSERGRAENGSLNX|||||||||||||||||||||||||||:|||||| |||||||||| m639-1DSKPLMKPYAPKIQTRYQAMKDELLKEVETRQSEWGRAENGSLNX       310       320       330       340The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2049>:

a639-1.seq 1 ATGAGCCTGC CCGCAATGGA TGCCGGTATT TATCTCGAAG AAACTGCCCC 51GCGCGCCCTG ATTGAACACA ATAATATTTT GGATAATTCG GTCGGCGTCT 101 ATCTGCATGGTTCTGCCGAT GCGATGGTGC GGGAGAATAA AATCGTCGGC 151 GACGCGACTT TGCGCGTGAACGAGCGCGGC AATGGCGTTA CCGTTTGGAA 201 CGCGCCCGGC GCGCAGGTCG TCGGCAACGATATTTCCAAA GGGCGGGACG 251 GCATTTTTTC CAATACCAGC ACGCACAACA CCTATAAAAACAACCGCTTC 301 AGCGATTTGC GTTTCGCCGT CCACTATATG TACACCAACG ACAGCGAAAT351 CAGCGGCAAT ATTTCCGTGG GCAACAATAT GGGCTATGTG CTGATGTTTT 401CCGAGCGGCT CAAAGTGTTT GACAATATCG CCGTCGGCAG CCGCGACCAA 451 GGCATCATGCTCAACTATGT CAACTATTCC GATATTCACG ACAACATTAT 501 CAACAAAGCG GGCAAGTGCGTTTTTGCCTA CAATGCCAAC TACGATAAAC 551 TGTCCGCCAA TCATTTTGAA AACTGCCAAATCGGCATACA CTTTACCGCC 601 GCCATCGAAG GCACGTCCCT GCACGACAAT TCCTTTATCAACAACGAAAG 651 CCAGGTCAAA TACGTCAGCA CGCGCTTTCT CGACTGGAGC GAGGGCGGAC701 ACGGCAACTA TTGGAGCGAC AACAGCGCGT TCGATTTGAA CGGCGACGGC 751TTCGGAGACA GCGCGTACCG TCCCAACGGC ATCATCGACC AAATCATCTG 801 GCGCGCACCCGTATCGCGCC TCTTGATGAA CAGTCCCGCA ATCAGCATCG 851 TCAAATGGGC GCAGGCGCAATTTCCCGCCG TTTTGCCTGG CGGCGTGGTG 901 GACAGCAAAC CGCTGATGAA GCCTTATGCCCCCAAAATTC AAACCCGTTA 951 TCAGGCGATG AAGGACGGGC TGCTCAAAAA AGTCGAAACGCGGCAGTTGG 1001 AATGGGGCAG GGCGGAAAAC GGTTCTTTGA ACTAGThis corresponds to the amino acid sequence <SEQ ID 2050; ORF 639-1.a>:

a639-1.pep 1 MSLPAMDAGI YLEETAPRAL IEHNNILDNS VGVYLHGSAD AMVRENKIVG 51DATLRVNERG NGVTVWNAPG AQVVGNDISK GRDGIFSNTS THNTYKNNRF 101 SDLRFAVHYMYTNDSEISGN ISVGNNMGYV LMFSERLKVF DNIAVGSRDQ 151 GIMLNYVNYS DIHDNIINKAGKCVFAYNAN YDKLSANHFE NCQIGIHFTA 201 AIEGTSLHDN SFINNESQVK YVSTRFLDWSEGGHGNYWSD NSAFDLNGDG 251 FGDSAYRPNG IIDQIIWRAP VSRLLMNSPA ISIVKWAQAQFPAVLPGGVV 301 DSKPLMKPYA PKIQTRYQAM KDGLLKKVET RQLEWGRAEN GSLN*a639-1/m639-1 98.8% identity in 344 aa overlap        10        20        30        40        50        60 a639-1.pepMSLPAMDAGIYLEETAPRALIEHNNILDNSVGVYLHGSADAMVRENKIVGDATLRVNERG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m639-1MSLPAMDAGIYLEETAPRALIEHNNILDNSVGVYLHGSADAMVRENKIVGDATLRVNERG        10        20        30        40        50        60        70        80        90       100       110       120 a639-1.pepNGVTVWNAPGAQVVGNDISKGRDGIFSNTSTHNTYKNNRFSDLRFAVHYMYTNDSEISGN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m639-1NGVTVWNAPGAQVVGNDISKGRDGIFSNTSTHNTYKNNRFSDLRFAVHYMYTNDSEISGN        70        80        90       100       110       120       130       140       150       160       170       180 a639-1.pepISVGNNMGYVLMFSERLKVFDNIAVGSRDQGIMLNYVNYSDIHDNIINKAGKCVFAYNAN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m639-1ISVGNNMGYVLMFSERLKVFDNIAVGSRDQGIMLNYVNYSDIHDNIINKAGKCVFAYNAN       130       140       150       160       170       180       190       200       210       220       230       240 a639-1.pepYDKLSANHFENCQIGIHFLAAIEGTSLHDNSFINNESQVKYVSTRFLDWSEGGHGNYWSD|||| ||||||||||||||||||||||||||||||||||||||||||||||||||||||| m639-1YDKLFANHFENCQIGIHFLAAIEGTSLHDNSFINNESQVKYVSTRFLDWSEGGHGNYWSD       190       200       210       220       230       240       250       260       270       280       290       300 a639-1.pepNSAFDLNGDGFGDSAYRPNGIIDQIIWRAPVSRLLMNSPAISIVKWAQAQFPAVLPGGVV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m639-1NSAFDLNGDGFGDSAYRPNGIIDQIIWRAPVSRLLMNSPAISIVKWAQAQFPAVLPGGVV       250       260       270       280       290       300       310       320       330       340 a639-1.pepDSKPLMKPYAPKIQTRYQAMKDGLLKKVETRQLEWGRAENGSLNX|||||||||||||||||||||| |||:||||| |||||||||||| m639-1DSKPLMKPYAPKIQTRYQAMKDELLKEVETRQSEWGRAENGSLNX       310       320       330       340The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2051>:

g640.seq 1 ATGATTCATA TAATATCAAT ATTAAAGAGT ATCGGTATAT CGGGGATAGC 51TATGTCCTGT TTTTCAATCC GGCGTATGTC TGCGTTTCGG GCGCGGATAA 101 CGGCGTTTTTTACCGCCTTT GTCTTTTTGA CGGcggcACT GCCCGCTTAT 151 GcggAgcgTc tgcctGATTTTCTGgcgAAA ATacAgcctT CGGAAATTTT 201 TCCGGGTGCG GATCGTTACG GCAAGCCGGAaggcAAGCCT AtggtTGCCC 251 GCgtttACAA AGgcgATGAG CAGCTCGGTT TGGTTTATATCACGACCGAT 301 GCGGTCAATA CGCGCGGTTA TTCGAGCAAA CCGATCGATA CGCTGATGGC351 TTTGGCAAAC GACGGCACGA TAGCCGGGGC GAAACTGGTC GATCATCACG 401AACCGATTAT GCTGATCGGT ATCCCGCAAT CGCGTGTCGA TAAGTTCATC 451 GACAAATATATCGGTCTGAA TTTTATTAAA AATCCGCCGA CCCCGAGCGT 501 GGCGCCGGGC GACATCATCAGcggtGCGAC TgttaCACTG ATGGTGGTTA 551 ACGACAGCAT CCAGCGTTCG TACAAGGTCATTGCCAACCA ATACCGTCTG 601 GGTTCGGACA AGGCCCTTCA GACGGCATCC GCTTCCGATGTTCGGGAAGC 651 CGCGCCTGCG TCAGAAACCC GTCCGCGCCG TATGGCAAAT CCCGACAAGC701 AGGATATTTT GTCTTGGGAC GAACTTTTGA AACAAAAGGC CGTCGGCCAT 751CTGCATATCA CGCTCGATCA AATCAACAAA CTGTTTGAGA AAGGCGGCAA 801 GGCCGGCGTGGCCGATCACG CCGAACAGGG CGATCCTGAC GATACCTTTA 851 TTGATTTGTA TGTTGCCTTGGTCAGCCAGC CTTCCATCGG TAAAAGCCTG 901 CTGGGTGAGG ACGGCTGGGC GCATCTGCAAAAACGGCTGA AACCCGGGCA 951 GCAGGCGGTT TTGGTTGCCG GAGAGGGCCG TTATTCTTGGAAAGGTTCGG 1001 GCTATGTGCG CGGCGGTATT TTCGACCGTA TCGAGATGAT TCAGGGGGAG1051 AACAGCTTCC GTTTTACCGA TGCCCAACAC GAACGCGTCG TCGAGCTGTC 1101TGCCGCCGAT GCGCCGCGTT TTAAAGAAGT TTCTTGGTTT ACCATCCCTG 1151 AAGGCGTAGCGTTTGACGGT GCGGAGCCGT GGCGGCTGTA AThis corresponds to the amino acid sequence <SEQ ID 2052; ORF 640.ng>:

g640.pep 1 MIHIISILKS IGISGIAMSC FSIRRMSAFR ARITAFFTAF VFLTAALPAY 51AERLPDFLAK IQPSEIFPGA DRYGKPEGKP MVARVYKGDE QLGLVYITTD 101 AVNTRGYSSKPIDTLMALAN DGTIAGAKLV DHHEPIMLIG IPQSRVDKFI 151 DKYIGLNFIKNPPTPSVAPG DIISGATVTL MVVNDSIQRS YKVIANQYRL 201 GSDKALQTAS ASDVREAAPASETRPRRMAN PDKQDILSWD ELLKQKAVGH 251 LHITLDQINK LFEKGGKAGV ADHAEQGDPDDTFIDLYVAL VSQPSIGKSL 301 LGEDGWAHLQ KRLKPGQQAV LVAGEGRYSW KGSGYVRGGIFDRIEMIQGE 351 NSFRFTDAQH ERVVELSAAD APRFKEVSWF TIPEGVAFDG AEPWRL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2053>:

m640.seq (partial) 1 ATGATTCATA TAATATCAAT ATTAAAGAGT ATCGGTATATCGGGGATAGT 51 CATGTCCTGT TTTTCAATCA AACGTATGTC CGCGTTTCGG GCGCGGATAA 101CGGCGTTTTT TGCCGCCTTT GTCTTTTTGA CGGCGGCACT GCCCGCTTAT 151 GCGGAGCGTCTGCCTGATTT TCTGGCGAAA ATACAGCCTT CGGAAATTTT 201 TCCGGGTGCG GACCGTTACGGCAAGCCGGA AGGTAAGCCT ATGGTTGCCC 251 GCGTTTACAA AGGCGATGAG CAGTTGGGCTTGGTCTATAT CACGACCGAT 301 GCGGTCAATA CGCGCGGTTA TTCGAGCAAA CCGATTGATACGCTGATGGT 351 GTTGGCAAAC GACGGCACGA TAGCCGGGGC GAAACTGGTC GACCATCACG401 AACCGATTAT GCTGATCGGT ATCCCGCAT...This corresponds to the amino acid sequence <SEQ ID 2054; ORF 640>:

m640.pep (partial) 1MIHIISILKS IGISGIVMSC FSIKRMSAFR ARITAFFAAF VFLTAALPAY 51 AERLPDFLAKIQPSEIFPGA DRYGKPEGKP MVARVYKGDE QLGLVYITTD 101 AVNTRGYSSK PIDTLMVLANDGTIAGAKLV DHHEPIMLIG IPH... m640/g640 96.5% identity in 143 aa overlap        10        20        30        40        50        60 m640.pepMIHIISILKSIGISGIVMSCFSIKRMSAFRARITAFFAAFVFLTAALPAYAERLPDFLAK||||||||||||||||:||||||:|||||||||||||:|||||||||||||||||||||| g640MIHIISILKSIGISGIAMSCFSIRRMSAFRARITAFFTAFVFLTAALPAYAERLPDFLAK        10        20        30        40        50        60        70        80        90       100       110       120 m640.pepIQPSEIFPGADRYGKPEGKPMVARVYKGDEQLGLVYITTDAVNTRGYSSKPIDTLMVLAN||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||| g640IQPSEIFPGADRYGKPEGKPMVARVYKGDEQLGLVYITTDAVNTRGYSSKPIDTLMALAN        70        80        90       100       110       120       130       140 m640.pep DGTIAGAKLVDHHEPIMLIGIPH||||||||||||||||||||||: g640DGTIAGAKLVDHHEPIMLIGIPQSRVDKFIDKYIGLNFIKNPPTPSVAPGDIISGATVTL       130       140       150       160       170       180The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2055>:

a640.seq (partial) 1 ATGATTCATA TAATATCAAT ATTAAAGAGT ATCGGTATATCGGGGATAGT 51 CATGTCCTGT TTTTCAATCA AACGTATGTC CGCGTTTCGG GCGCGGATAA 101CGGCGTTTTT TGCCGCCTTT GTCTTTTTGA CGGCGGCACT GCCCGCTTAT 151 GCGGAGCGTCTGCCTGATTT TCTGGCGAAA ATACAGCCTT CGGAAATTGT 201 TCCGGGTGCG GACCGTTACAGCAAGCCGGA AGGTAAGCCT ATGGTTGCCC 251 GCGTTTACAA AGGCGATGAG CAGTTGGGCTTGGTCTATAT CACGACCGAT 301 GCGGTCAATA CGCGCGGTTA TTCGAGCAAA CCGATTGATACGCTGATGGC 351 GTTGGCTAAA GACGGTACGA TAGCCGGAGC GAAATTGGTT GATCACCATG401 AGTCGATTAT GCTGATCGGT ATCCCGCAT...This corresponds to the amino acid sequence <SEQ ID 2056; ORF 640.a>:

a640.pep (partial) Length: 143 1MIHIISILKS IGISGIVMSC FSIKRMSAFR ARITAFFAAF VFLTAALPAY 51 AERLPDFLAKIQPSEIVPGA DRYSKPEGKP MVARVYKGDE QLGLVYITTD 101 AVNTRGYSSK PIDTLMALAKDGTIAGAKLV DHHESIMLIG IPH... m640/a640 96.5% identity in 143 aa overlap        10        20        30        40        50        60 m640.pepMIHIISILKSIGISGIVMSCFSIKRMSAFRARITAFFAAFVFLTAALPAYAERLPDFLAK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a640MIHIISILKSIGISGIVMSCFSIKRMSAFRARITAFFAAFVFLTAALPAYAERLPDFLAK        10        20        30        40        50        60        70        80        90       100       110       120 m640.pepIQPSEIFPGADRYGKPEGKPMVARVYKGDEQLGLVYITTDAVNTRGYSSKPIDTLMVLAN|||||| ||||||:||||||||||||||||||||||||||||||||||||||||||:||: a640IQPSEIVPGADRYSKPEGKPMVARVYKGDEQLGLVYITTDAVNTRGYSSKPIDTLMALAK        70        80        90       100       110       120       130       140 m640.pep DGTIAGAKLVDHHEPIMLIGIPH|||||||||||||| |||||||| a640 DGTIAGAKLVDHHESIMLIGIPH       130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2057>:

g642.seq 1 ATGCGGTATC CGCCGCAATC GGCGGTTTTG CAGAATGCCG CGCGTTGCCT 51TTTGCGCCGC CCGAAATCTG CCTGCCGCCG TATTTGCCCG CTATCCGCAA 101 TATCGGCAGTCCAATATATC TTTGCGGATG TCGTTCAGCA GGAAGGCTGT 151 GGTGTCTTCG TGTTCCTCCTGTACGAAGAC AAAAAGTCGG GCGATGATTT 201 TGCCGATGAA GACTTTTTGC AGGGCGCAGGCGTCGGTCAG GGTGTGTTCC 251 TGCAGGAAGC TGCGGATGTC TTCGGGCAAA GCGTAgtCgcgGGCAACGGC 301 GGcaaagcgG ACatcggtTT Gcacggcgtc gagCAGGGtt tggtTTTTGT351 CCAACTTAAT GCCTGCTTCT TTTTCTTCGG CGGTGGCGCG GACGAACTGG 401TCGTAAATTT CGGCATAAAG CATATCGTTC GGGCCTTCAA AAATCGTGAA 451 GGGGCGGATATCGATGGCGA TATTGCCGGC TGGGTGTCCG CGTTCAAAAC 501 CCTTCGCGCC CAAGAGTTTTTGCAACATTT GCGCGGCGgc gTAAGTGTAT 551 TCCGTGGCGa ggGTTTTGAc gatgTTCGCCTCCATCAATT GATGGGCGAc 601 ggGCGcgacg ggCGAAACGG AATGGCAGAC GTAGCGGTAAAGGATTTCGG 651 AAACCTGATG GCGGCGTTGG ATTTCGCGGC GTTCGTAATC GACGAATCTG701 ATATCGTTGC GGACATATCG GTTCAGGTTG TCAAGGATGT ATTCCATAAT 751GCCGTGCGTC ATGCCGATCA GTTGCAGGCG GCTGCGGATA AAGATGTTTT 801 GGAACGCGCGCAAACCGGCA GCGTCGCCCC GGGAGAGTTT CATCACGGCG 851 GTTGCAGGCA TTTCGGCATCGATGCGGTTG ACGGCGTAAC GGACGGCGCG 901 CAGGCCTTCG GATGCGAGGG TTTCGCAGCGGATGTATGTT TTGGGGACGA 951 GCAGCAGGTC GATGactttg gcgagtttgC Cgtttttgcgctctttggcg 1001 gcaacgaggA GGAAGTCGCT TTGCGAATTG CCCTGCCAGT ATTTCGCGGC1051 GttgACGTAA ATGGTTtgtt cgtcggtata ttcgtagcag gactgcaTTT 1101CGCGTGCAAt cgCcgcgccg gaggtTtcgg gttcggtaAc gcccaaacgg 1151 cggctttcgcctTTGAAAAT CATGTCCAAA CCTTGTGCGA CTTGCgcttc 1201 gccgccgaac tCTTGCAGAGGCTGCAACAC CAGCGCGCCT TCGATGCCGG 1251 TACGCAGCGT AACGGGCACG CCGTAATGCCCCGCAATCCT TAGThis corresponds to the amino acid sequence <SEQ ID 2058; ORF 642.ng>:

g642.pep 1 MRYPPQSAVL QNAARCLLRR PKSACRRICP LSAISAVQYI FADVVQQEGC 51GVFVFLLYED KKSGDDFADE DFLQGAGVGQ GVFLQEAADV FGQSVVAGNG 101 GKADIGLHGVEQGLVFVQLN ACFFFFGGGA DELVVNFGIK HIVRAFKNRE 151 GADIDGDIAG WVSAFKTLRAQEFLQHLRGG VSVFRGEGFD DVRLHQLMGD 201 GRDGRNGMAD VAVKDFGNLM AALDFAAFVIDESDIVADIS VQVVKDVFHN 251 AVRHADQLQA AADKDVLERA QTGSVAPGEF HHGGCRHFGIDAVDGVTDGA 301 QAFGCEGFAA DVCFGDEQQV DDFGEFAVFA LFGGNEEEVA LRIALPVFRG351 VDVNGLFVGI FVAGLHFACN RRAGGFGFGN AQTAAFAFEN HVQTLCDLRF 401AAELLQRLQH QRAFDAGTQR NGHAVMPRNP *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2059>:

m642.seq (partial) 1 GCCTGCCGCC GTATTTGCCC GCTACCCGCA ATATCGGCAGTCCAATATAT 51 CTTTGCGGAT GTCGTTCAGC AGGAAGGCTG CGGTGTCTTC GTGTTTCGCC 101TGTACGAAGA CAAAGAGTCG GGCGATGATT TTGCCGATAA AGACTTTTTG 151 CAGGGCGCAGGCATCGGTCA GGGTGTGTTC CTGCAGGAAG CTGCGGATGT 201 CTTCAGGCAA AGTGTAGTCGCGGGCGACGG CGGCAAAGCG GGCATCGGTT 251 TGCAGGCGGT CGAGCAGGGT TTGGTTTTTGTCCAACTTCA TGCCTGCTTC 301 TTTTTCTTCG GCGGTGGCGC GGACAAACTG GTCGTAAATTTCGGCATAAA 351 GCATATCGTT CGGGCCTTCA AAAATCGTGA AGGGGCGGAT GTCGATAGCG401 ATATTGCCGG CGGTGTGTCC GCGTTCAAAA CCCTTCGCAC CCAAGAGTTT 451TTGCAACATT TGCGCGGCGG CGTAAGTGTA TTCCGTGGCG AGGGTTTTGA 501 CGATGTTCGCCTCCATCAGC TGATGGGCGA CGGGGGCAAC AGGCGAAACG 551 GAATGGCAGA CGTAGCGGTAAAGAATCTCG GAAACCTGAT GGCGGCGCCG 601 GATTTCGCGG CGTTCGTAAT CGACGAATTTGATGTCGTTG CGGACGTATC 651 GTTCCAGATT TTCAAGGATG TATTCCATAA TGCCGTGCGTCATGCCGATC 701 AGTTGCAGGC GGCTGCGGAT AAAGATGTTT TGGAACGCGC GCAAACCGGC751 AGCGTCGCTC TGGGAGAGTT TCATCACGGC GGTTGCAGGC ATTTCGGCAT 801CGATGCGGTT GACGGCGTAA CGGACGGCGC GCAAGCCTTC GGATGCGAGG 851 GTTTCGCAGCGGATGTATGT TTTGGGGACG AGCAGCAGGT CGATGACTTT 901 GGCGAGTTTG CCGTTTTTGCGCTCTTTGGC GGCAACGAGG AGGAAGTCGC 951 TTTGCGAGTT GCCCTGCCAG TATTTCGCGGCGTTGACGTA AATGGTTTGT 1001 CCGTCGATAT ATTCGTAGTA GGACTGCATT TCGCGTGCAATCGCCGCGCC 1051 GGAGGTTTCG GGTTCGGTAA CACCCAAACC GCCGCCCTCG CCTTTGAAAA1101 TCATCTCCAA ACCTTGCGCG ACTTGCGCTT CATCGCCGAA CTCTTGCAGT 1151GGCTGCAACA CCAGCGCGCC TTCGATGCCG GTACGCAGCG TAACGGGCAC 1201 GCCGTAATGCCCCGCAATCC GThis corresponds to the amino acid sequence <SEQ ID 2060; ORF 642>:

m642.pep (partial) 1 ACRRICPLPA ISAVQYIFAD VVQQEGCGVF VFRLYEDKESGDDFADKDFL 51 QGAGIGQGVF LQEAADVFRQ SVVAGDGGKA GIGLQAVEQG LVFVQLHACF 101FFFGGGADKL VVNFGIKHIV RAFKNREGAD VDSDIAGGVS AFKTLRTQEF 151 LQHLRGGVSVFRGEGFDDVR LHQLMGDGGN RRNGMADVAV KNLGNLMAAP 201 DFAAFVIDEF DVVADVSFQIFKDVFHNAVR HADQLQAAAD KDVLERAQTG 251 SVALGEFHHG GCRHFGIDAV DGVTDGAQAFGCEGFAADVC FGDEQQVDDF 301 GEFAVFALFG GNEEEVALRV ALPVFRGVDV NGLSVDIFVVGLHFACNRRA 351 GGFGFGNTQT AALAFENHLQ TLRDLRFIAE LLQWLQHQRA FDAGTQRNGH401 AVMPRNP m642/g642 90.4% identity in 407 aa overlap                               10        20        30 m642.pep                       ACRRICPLPAISAVQYIFADVVQQEGCGVFVFRLYED                       |||||||| ||||||||||||||||||||||| |||| g642MRYPPQSAVLQNAARCLLRRPKSACRRICPLSAISAVQYIFADVVQQEGCGVFVFLLYED        10        20        30        40        50        60 40        50        60        70        80        90 m642.pepKESGDDFADKDFLQGAGIGQGVFLQEAADVFRQSVVAGDGGKAGIGLQAVEQGLVFVQLH|:|||||||:|||||||:||||||||||||| ||||||:|||| |||::||||||||||: g642KKSGDDFADEDFLQGAGVGQGVFLQEAADVFGQSVVAGNGGKADIGLHGVEQGLVFVQLN        70        80        90       100       110       120100       110       120       130       140       150 m642.pepACFFFFGGGADKLVVNFGIKHIVRAFKNREGADVDSDIAGGVSAFKTLRTQEFLQHLRGG|||||||||||:|||||||||||||||||||||:|:|||| ||||||||:|||||||||| g642ACFFFFGGGADELVVNFGIKHIVRAFKNREGADIDGDIAGWVSAFKTLRAQEFLQHLRGG       130       140       150       160       170       180160       170       180       190       200       210 m642.pepVSVFRGEGFDDVRLHQLMGDGGNRRNGMADVAVKNLGNLMAAPDFAAFVIDEFDVVADVS||||||||||||||||||||| : ||||||||||::|||||| ||||||||| |:|||:| g642VSVFRGEGFDDVRLHQLMGDGRDGRNGMADVAVKDFGNLMAALDFAAFVIDESDIVADIS       190       200       210       220       230       240220       230       240       250       260       270 m642.pepFQIFKDVFHNAVRHADQLQAAADKDVLERAQTGSVALGEFHHGGCRHFGIDAVDGVTDGA  |:|||||||||||||||||||||||||||||||| ||||||||||||||||||||||| g642VQVVKDVFHNAVRHADQLQAAADKDVLERAQTGSVAPGEFHHGGCRHFGIDAVDGVTDGA       250       260       270       280       290       300280       290       300       310       320       330 m642.pepQAFGCEGFAADVCFGDEQQVDDFGEFAVFALFGGNEEEVALRVALPVFRGVDVNGLSVDI||||||||||||||||||||||||||||||||||||||||||:||||||||||||| | | g642QAFGCEGFAADVCFGDEQQVDDFGEFAVFALFGGNEEEVALRIALPVFRGVDVNGLFVGI       310       320       330       340       350       360340       350       360       370       380       390 m642.pepFVVGLHFACNRRAGGFGFGNTQTAALAFENHLQTLRDLRFIAELLQWLQHQRAFDAGTQR||:|||||||||||||||||:||||:|||||:||| |||| ||||| ||||||||||||| g642FVAGLHFACNRRAGGFGFGNAQTAAFAFENHVQTLCDLRFAAELLQRLQHQRAFDAGTQR       370       380       390       400       410       420 400m642.pep NGHAVMPRNP |||||||||| g642 NGHAVMPRNPX        430The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2061>:

a642.seq (partial) 1 GCCTGCCGCC GTATTTGCCC GCTATCCGCA ATATCGGCAGTCCAATATGT 51 CTTTGCGGAT GTCGTTCAGC AGGAAGGCTG CGGTGTCTTC GTGTTCCGCC 101TGTACGAAGA CAAAGAGTCG GGCGATGATT TTGCCGATAA AGACTTTTTG 151 CAGGGCGCAGGCATCGGTCA GGGTGTGTTC CTGCAGGAAG CTGCGGATGT 201 CTTCGGGCAA AGTGTAGTCGCGGGCGACGG CGGCAAAGCG GGCATCGGTT 251 TGCAGGCGGT CGAGCAGGGT TTGGTTTTTGTCCAACTTCA TGCCTGCTTC 301 TTTTTCTTCG GCGGTGGCGC GGACAAACTG GTCGTAAATTTCGGCATAAA 351 GCATATCGTT CGGGCCTTCA AAAATCGTGA AGGGGCGGAT GTCGATAGCG401 ATATTGCCGG CGGTGTGTCC GCGTTCAAAA CCCTTCGCGC CCAAGAGTTT 451TTGCAACATT TGCGCGGCGG CGTAAGTGTA TTCCGTGGCG AGGGTTTTGA 501 CGATGTTCGCCTCCATCAGT TGATGGGCGA CGGGTGCAAC GGGCGAAACG 551 GAATGGCAGA CGTAGCGGTAAAGAATCTCG GAAACCTGAT GGCGGCGCCG 601 GATTTCGCGG CGTTCGTAAT CGACGAATCTGATGTCGTTG CGGACGTATC 651 GTTCCAGGTT TTCAAGGGTG TATTCCATAA TGCCGTGCGTCATGCCGATC 701 AGTTGCAGGC GGCTGCGGAT AAAGATGTTT TGGAACGCGC GCAAACCGGC751 AGCGTCGCTC TGGGAGAGTT TCATCACGGC GGTTGCAGGC ATTTCGGCAT 801CGATGCGGTT GACGGCGTAA CGGACGGCGC GCAAGCCTTC GGATGCGAGG 851 GTTTCGCAGCGGATGTATGT TTTGGGGACG AGCAGCAGGT CGATGACTTT 901 GGCGAGTTTG CCGTTTTTGCGCTCTTTGGC GGCAACGAGG AGGAAGTCGC 951 TTTGCGAGTT GCCCTGCCAG TATTTCGCGGCGTTGACGTA AATGGTTTGT 1001 CCGTCGGTAT ATTCGTAGTA AGACTGCATT TCTCGGGCAATCGCCGCGCC 1051 GGAGGTTTCG GGTTCGGTAA CGCCTAAACC GCCGCCCTCG CCTTTGAAAA1101 CCATGTCCAA ACCCTGTGCG ATTTGCGCTT CATCGCCGAA CTCTTGCAGT 1151GGCTGCAACA CCAGCGCGCC TTCGATGCCG GTACGCAGCG TAACGGGCAC 1201 GCCGTAATGCCCCGCAATCC GThis corresponds to the amino acid sequence <SEQ ID 2062; ORF 642.a>:

a642.pep Length: 407 1 ACRRICPLSA ISAVQYVFAD VVQQEGCGVF VFRLYEDKESGDDFADKDFL 51 QGAGIGQGVF LQEAADVFGQ SVVAGDGGKA GIGLQAVEQG LVFVQLHACF 101FFFGGGADKL VVNFGIKHIV RAFKNREGAD VDSDIAGGVS AFKTLRAQEF 151 LQHLRGGVSVFRGEGFDDVR LHQLMGDGCN GRNGMADVAV KNLGNLMAAP 201 DFAAFVIDES DVVADVSFQVFKGVFHNAVR HADQLQAAAD KDVLERAQTG 251 SVALGEFHHG GCRHFGIDAV DGVTDGAQAFGCEGFAADVC FGDEQQVDDF 301 GEFAVFALFG GNEEEVALRV ALPVFRGVDV NGLSVGIFVVRLHFSGNRRA 351 GGFGFGNA*T AALAFENHVQ TLCDLRFIAE LLQWLQHQRA FDAGTQRNGH401 AVMPRNP m642/a642 95.8% identity in 407 aa overlap        10        20        30        40        50        60 m642.pepACRRICPLPAISAVQYIFADVVQQEGCGVFVFRLYEDKESGDDFADKDFLQGAGIGQGVF|||||||| |||||||:||||||||||||||||||||||||||||||||||||||||||| a642ACRRICPLSAISAVQYVFADVVQQEGCGVFVFRLYEDKESGDDFADKDFLQGAGIGQGVF        10        20        30        40        50        60        70        80        90       100       110       120 m642.pepLQEAADVFRQSVVAGDGGKAGIGLQAVEQGLVFVQLHACFFFFGGGADKLVVNFGIKHIV|||||||| ||||||||||||||||||||||||||||||||||||||||||||||||||| a642LQEAADVFGQSVVAGDGGKAGIGLQAVEQGLVFVQLHACFFFFGGGADKLVVNFGIKHIV        70        80        90       100       110       120       130       140       150       160       170       180 m642.pepRAFKNREGADVDSDIAGGVSAFKTLRTQEFLQHLRGGVSVFRGEGFDDVRLHQLMGDGGN||||||||||||||||||||||||||:||||||||||||||||||||||||||||||| | a642RAFKNREGADVDSDIAGGVSAFKTLRAQEFLQHLRGGVSVFRGEGFDDVRLHQLMGDGCN       130       140       150       160       170       180       190       200       210       220       230       240 m642.pepRRNGMADVAVKNLGNLMAAPDFAAFVIDEFDVVADVSFQIFKDVFHNAVRHADQLQAAAD|||||||||||||||||||||||||||| |||||||||:|| ||||||||||||||||| a642GRNGMADVAVKNLGNLMAAPDFAAFVIDESDVVADVSFQVFKGVFHNAVRHADQLQAAAD       190       200       210       220       230       240       250       260       270       280       290       300 m642.pepKDVLERAQTGSVALGEFHHGGCRHFGIDAVDGVTDGAQAFGCEGFAADVCFGDEQQVDDF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a642KDVLERAQTGSVALGEFHHGGCRHFGIDAVDGVTDGAQAFGCEGFAADVCFGDEQQVDDF       250       260       270       280       290       300       310       320       330       340       350       360 m642.pepGEFAVFALFGGNEEEVALRVALPVFRGVDVNGLSVDIFVVGLHFACNRRAGGFGFGNTQT||||||||||||||||||||||||||||||||||| |||| |||: |||||||||||: | a642GEFAVFALFGGNEEEVALRVALPVFRGVDVNGLSVGIFVVRLHFSGNRRAGGFGFGNAXT       310       320       330       340       350       360       370       380       390       400 m642.pepAALAFENHLQTLRDLRFIAELLQWLQHQRAFDAGTQRNGHAVMPRNP||||||||:||| |||||||||||||||||||||||||||||||||| a642AALAFENHVQTLCDLRFIAELLQWLQHQRAFDAGTQRNGHAVMPRNP       370       380       390       400The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2063>:

g643.seq 1 ATGGTGTTGC CTTTGATGTT GTTGGCGACA ATCAGgTcgg CTACGCTGAc 51gttgtancGt TTGGcaATGt tGaaCAgggt gtcgccTTCT ACAACGCGGT 101 GGATGCTGGCATGGagcGGG GAGGTTTCGG CTTCGCCGTC GGCAGCTTTG 151 GCTACGCGCG TTTCCAAACGTGCCCGGCGT TtgCCGTCGG CGGCAACGGT 201 ATGTTGCGGA GATGAGGAAA TGTTGTGTTCGGCAACTGTG TCAGGCGTGC 251 CGATGACGGC GGagaTGGTT TCTTCAGCCT GCCGGCGCaggTTGTTTCGG 301 GCAACAAGCT GCATGAGTTC GTCTGCCGCC TGCATGTCGT TTGGGGGGAt351 GACCTGCGCg aGTGtTGCGG TTTGGGTTTC agacgGCATG GCAGTCTGTT 401TTTcggTTTG aThis corresponds to the amino acid sequence <SEQ ID 2064; ORF 643>:

g643.pep 1 MVLPLMLLAT IRSATLTLXR LAMLNRVSPS TTRWMLAWSG EVSASPSAAL 51ATRVSKRARR LPSAATVCCG DEEMLCSATV SGVPMTAEMV SSACRRRLFR 101 ATSCMSSSAACMSFGGMTCA SVAVWVSDGM AVCFSV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2065>:

m643.seq 1 ATGGTGTTGC CTTTGATGTT GTTGGCGACA ATCAGGTCGG CTACACTGAC 51GTTGTAGCGT TTGGCAATGT TGAACAGGGT GTCGCCTTCT ACAACGCGGT 101 GGATGCTGGCATGGAGCGGG GAGATTTCGG CTTCGCCGTC GGCAGCTTTG 151 GCTACGCGCG TTTCCAAACGTACCCGGCGT TTGCCGTCGG CGGCAGCGGT 201 ATGTTGCGGA GATGCGGAAA TTTTGTGTTCGGCAACTGTG TCAGGCGTGC 251 CGATGACGGC GGAGATGGTT TCTTCAGCCT GTCGGCGCAGGTTGTTTCGG 301 GCAACAAGCT GCATGAGTTC GTCTGCCGCC TGCATGTCGT TTTGGGGGAT351 GATCTGCGCG AGTGTTGCGG TTTGGGTTTC AGACGGCATG GCGGTCTGTT 401TTTCGGTTTG AThis corresponds to the amino acid sequence <SEQ ID 2066; ORF 643>:

m643.pep 1 MVLPLMLLAT IRSATLTL*R LAMLNRVSPS TTRWMLAWSG EISASPSAAL 51ATRVSKRTRR LPSAAAVCCG DAEILCSATV SGVPMTAEMV SSACRRRLFR 101 ATSCMSSSAACMSFWGMICA SVAVWVSDGM AVCFSV*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 643 shows 94.9% identity over a 136 aa overlap with a predicted ORF(ORF643.a) from N. gonorrhoeae:

m643/g643         10        20        30        40        50        60m643.pep MVLPLMLLATIRSATLTLXRLAMLNRVSPSTTRWMLAWSGEISASPSAALATRVSKRTRR|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||:|| g643MVLPLMLLATIRSATLTLXRLAMLNRVSPSTTRWMLAWSGEVSASPSAALATRVSKRARR        10        20        30        40        50        60        70        80        90       100       110       120 m643.pepLPSAAAVCCGDAEILCSATVSGVPMTAEMVSSACRRRLFRATSCMSSSAACMSFWGMICA|||||:||||| |:|||||||||||||||||||||||||||||||||||||||| || || g643LPSAATVCCGDEEMLCSATVSGVPMTAEMVSSACRRRLFRATSCMSSSAACMSFGGMTCA        70        80        90       100       110       120        130m643.pep SVAVWVSDGMAVCFSVX ||||||||||||||||| g643 SVAVWVSDGMAVCFSVX       130The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2067>:

a643.seq 1 ATGGTGTTGC CTTTGATGTT GTTGGCGACA ATCAGGTCGG CTACACTGAC 51GTTGTAGCGT TTGGCAATGT TGAACAGGGT GTCGCCTTCT ACAACGCGGT 101 GGATGCTGGCATGGAGCGGG GAGATTTCGG CTTCGCCGTC GGCAGCTTTG 151 GCTACGCGCG TTTCCAAACGTACCCGGCGT TTGCCGTCGG CGGCAACGGT 201 ATGTTGCGGA GATGAGGAAA TGTTGTGTTCGGCAACTGTG TCAGGCGTGC 251 CGATGACGGC AGAGATGGTT TCTTCAGCCT GTCGGCGCAGGTTGTTTCGG 301 GCAACAAGCT GCATGAGTTC GTCTGCCGCC TGCATGTCGT TTTGGGGGAC351 GATCTGCGCG AGTGTTGCGG TTTGGGTTTC AGACGGCATG GCGGTCTGTT 401TTTCGGTTTG AThis corresponds to the amino acid sequence <SEQ ID 2068; ORF 643.a>:

a643.pep 1 MVLPLMLLAT IRSATLTL*R LAMLNRVSPS TTRWMLAWSG EISASPSAAL 51ATRVSKRTRR LPSAATVCCG DEEMLCSATV SGVPMTAEMV SSACRRRLFR 101 ATSCMSSSAACMSFWGTICA SVAVWVSDGM AVCFSV* m643/a643 97.1% identity in 136 aa overlap        10        20        30        40        50        60 m643.pepMVLPLMLLATIRSATLTLXRLAMLNRVSPSTTRWMLAWSGEISASPSAALATRVSKRTRR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a643MVLPLMLLATIRSATLTLXRLAMLNRVSPSTTRWMLAWSGEISASPSAALATRVSKRTRR        10        20        30        40        50        60        70        80        90       100       110       120 m643.pepLPSAAAVCCGDAEILCSATVSGVPMTAEMVSSACRRRLFRATSCMSSSAACMSFWGMICA|||||:||||| |:|||||||||||||||||||||||||||||||||||||||||| ||| a643LPSAATVCCGDEEMLCSATVSGVPMTAEMVSSACRRRLFRATSCMSSSAACMSFWGTICA        70        80        90       100       110       120        130m643.pep SVAVWVSDGMAVCFSVX ||||||||||||||||| a643 SVAVWVSDGMAVCFSVX       130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2069>:

g644.seq 1 ATGCCGTCTG AAAGGccgGC GGATTGTTGC CCGGTGCACT TTGTGGTAAA 51GTTTAGAAAA TTAACTCTAA ACTGTGGCAG GCGGTTTGAC CGGCCGCCGA 101 TTAATGGGAACCGACAGAGG AAGCCGATGA TACACACCGA ACCGAGCGCG 151 CAGCCGTCAA CCATGGACACGGCTGCTTTT TTAAagcaca tcgaatCCGC 201 ATTcCCCCGC ATTTTTTCAG ACGGCATCGACCTGATGCGA TACCTGCCCG 251 AAGACAAATG GCTTGCCTTG AAGCAGGCGG GTTTGCTGTTGCCCTTCCTC 301 GACAAAAAAC ACGGCGGGCG CAAGGGCAGT CAGTTTGAAA TCCAAGAAGT351 CCTAAGGATT GCGGGGCATT ACGGCGTGCC CGTTACGCTG CGTACCGGCA 401TCGAAGGCGC GCTGGTGTTG CAGCCTCTGC AAGagttcgg cggcgaagcG 451 CAAGTCGCACAAGGTTTGGA CATGATTTTC AAaggcgaaa gccgccgttt 501 gggcgTtacc gaacccgaAacctccggcgc gGcgaTTGCA CGCGAAAtgc 551 agtcctgcta cgaatatacc gacgaacaAACCATTTACGT caaCGCCGCG 601 AAATACTGGC AGGGCAATTC GCAAAGCGAC TTCCTcctcgttgccgccaa 651 agagcgcaaa aacGGcaaac tcgccaaagt CATCGACCTG CTGCTCGTCC701 CCAAAACATA CATCCGCTGC GAAACCCTCG CATCCGAAGG CCTGCGCGCC 751GTCCGTTACG CCGTCAACCG CATCGATGCC GAAATGCCTG CAACCGCCGT 801 GATGAAACTCTCCCGGGGCG ACGCTGCCGG TTTGCGCGCG TTCCAAAACA 851 TCTTTATCCG CAGCCGCCTGCAACTGATCG GCATGACGCA CGGCATTATG 901 GAATACATCC TTGACAACCT GAACCGATATGTCCGCAACG ATATCAGATT 951 CGTCGATTAC GAACGCCGCG AAATCCAACG CCGCCATCAGGTTTCCGAAA 1001 TCCTTTACCG CTACGTCTGC CATTCCGTTT CGcccgtcgC GCccgTCGCC1051 CATCAATTGA TGGAGGCGAA catcgTCAAA ACcctCGCCA CGGAATACAC 1101TTAcgcCGCC GCGCAAATGT TGCAAAAACT CTTGGGCGCG AAGGGTTTTG 1151 AACGCGGACACCCAGCCGGC AATATCGCCA TCGATATCCG CCCCTTCACG 1201 ATTTTTGAAG GCCCGAACGATATGCTTTAT GCCGAAATTT ACGACCAGTT 1251 CGTCCGCGCC ACCGCCGAAG AAAAAGAAGCAGGCATTAAG TTGGACAAAA 1301 accaaaCCCT Gctcgacgcc gtgCAAaccg atGTCcgctttgCCGCCGTT 1351 GCCcgcGacT ACGCTTTGCC CGAAGACATC CGCAGCTTCC TGCAGGAACA1401 CACCCTGACC GACGCCTGCG CCCTGCAAAA AGTCTTCATC GGCAAAATCA 1451TCGCCCGACT TTTTGTCTTC GTACAGGAGG AACACGAAGA CACCACAGCC 1501 TTCCTGCTGAACGACATCCG CAAAGATATA TTGGACTGCC GATATTGCGG 1551 ATAGThis corresponds to the amino acid sequence <SEQ ID 2070; ORF 644.ng>:

g644.pep 1 MPSERPADCC PVHFVVKFRK LTLNCGRRFD RPPINGNRQR KPMIHTEPSA 51QPSTMDTAAF LKHIESAFPR IFSDGIDLMR YLPEDKWLAL KQAGLLLPFL 101 DKKHGGRKGSQFEIQEVLRI AGHYGVPVTL RTGIEGALVL QPLQEFGGEA 151 QVAQGLDMIF KGESRRLGVTEPETSGAAIA REMQSCYEYT DEQTIYVNAA 201 KYWQGNSQSD FLLVAAKERK NGKLAKVIDLLLVPKTYIRC ETLASEGLRA 251 VRYAVNRIDA EMPATAVMKL SRGDAAGLRA FQNIFIRSRLQLIGMTHGIM 301 EYILDNLNRY VRNDIRFVDY ERREIQRRHQ VSEILYRYVC HSVSPVAPVA351 HQLMEANIVK TLATEYTYAA AQMLQKLLGA KGFERGHPAG NIAIDIRPFT 401IFEGPNDMLY AEIYDQFVRA TAEEKEAGIK LDKNQTLLDA VQTDVRFAAV 451 ARDYALPEDIRSFLQEHTLT DACALQKVFI GKIIARLFVF VQEEHEDTTA 501 FLLNDIRKDI LDCRYCG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2071>:

m644.seq 1 ATGCCGTCTG AAAGGTCGGC GGATTGTTGC CCGGCGCACT TTGTGGTAAA 51GTTTAGAAAA TCAACTCTAA ACTGTGGCAG GCGGTTTGAC CGGCCGCCGA 101 TTAATGGGAACCGACAGAGG AAGCCGATGA TACACACCGA ACCGAGCGCG 151 CAGCCGTCAA CTATGGACACGGCTGCTTTT TTAAAGCACA TCGAATCCGC 201 ATTCCGCCGC ATTTTTTCAG ACGGTATCGACCTGATGCGA TACCTGCCCG 251 AAGACAAATG GCTTGCCTTG AAGCAGGCGG GTTTGCTGTTGCCCTTCCTC 301 GACAAAAAAT ACGGCGGGCG CAAGGGCAGC CAGTTTGAAA TCCAAGAAGT351 CcTGCGGATT GCGGGGCATT ACGGCGTGCC CGTTACGCTG CGTACCGGCA 401TCGAAGGCGC GCTGGTGTTG CAGCCACTGC AAGAGTTCGG CGATGAAGCG 451 CAAGTCGCGCAAGGTTTGGA GATGATTTTC AAAGGCGAGG GCGGCGGTTT 501 GGGTGTTACC GAACCCGAAACCTCCGGCGC GGCGATTGCA CGCGAAATGC 551 AGTCCTACTA CGAATATATC GACGGACAAACCATTTACGT CAACGCCGCG 601 AAATACTGGC AGGGCAACTC GCAAAGCGAC TTCCTCCTCGTTGCCGCCAA 651 AGAGCGCAAA AACGGCAAAC TCGCCAAAGT CATCGACCTG CTGCTCGTCC701 CCAAAACATA CATCCGCTGC GAAACCCTCG CATCCGAAGG CTTGCGCGCC 751GTCCGTTACG CCGTCAACCG CATCGATGCC GAAATGCCTG CAACCGCCGT 801 GATGAAACTCTCCCAGAGCG ACGCTGCCGG TTTGCGCGCG TTCCAAAACA 851 TCTTTATCCG CAGCCGCCTGCAACTGATCG GCATGACGCA CGGCATTATG 901 GAATACATCC TTGAAAATCT GGAACGATACGTCCGCAACG ACATCAAATT 951 CGTCGATTAC GAACGCCGCG AAATCCGGCG CCGCCATCAGGTTTCCGAGA 1001 TTCTTTACCG CTACGTCTGC CATTCCGTTT CGCCTGTTGC CCCCGTCGCC1051 CATCAGCTGA TGGAGGCGAA CATCGTCAAA ACCCTCGCCA CGGAATACAC 1101TTACGCCGCC GCGCAAATGT TGCAAAAACT CTTGGGTGCG AAGGGTTTTG 1151 AACGCGGACACACCGCCGGC AATATCGCTA TCGACATCCG CCCCTTCACG 1201 ATTTTTGAAG GCCCGAACGATATGCTTTAT GCCGAAATTT ACGACCAGTT 1251 TGTCCGCGCC ACCGCCGAAG AAAAAGAAGCAGGCATGAAG TTGGACAAAA 1301 ACCAAACCCT GCTCGACCGC CTGCAAACCG ATGCCCGCTTTGCCGCCGTC 1351 GCCCGCGACT ACACTTTGCC TGAAGACATC CGCAGCTTCC TGCAGGAACA1401 CACCCTGACC GATGCCTGCG CCCTGCAAAA AGTCTTTATC GGCAAAATCA 1451TCGCCCGACT CTTTGTCTTC GTACAGGCGA AACACGAAGA CACCGCAGCC 1501 TTCCTGCTGAACGACATCCG CAAAGATATA TTGGACTGCC GATATTGCGG 1551 GTAGThis corresponds to the amino acid sequence <SEQ ID 2072; ORF 644>:

m644.pep 1 MPSERSADCC PAHFVVKFRK STLNCGRRFD RPPINGNRQR KPMIHTEPSA 51QPSTMDTAAF LKHIESAFRR IFSDGIDLMR YLPEDKWLAL KQAGLLLPFL 101 DKKYGGRKGSQFEIQEVLRI AGHYGVPVTL RTGIEGALVL QPLQEFGDEA 151 QVAQGLEMIF KGEGGGLGVTEPETSGAAIA REMQSYYEYI DGQTIYVNAA 201 KYWQGNSQSD FLLVAAKERK NGKLAKVIDLLLVPKTYIRC ETLASEGLRA 251 VRYAVNRIDA EMPATAVMKL SQSDAAGLRA FQNIFIRSRLQLIGMTHGIM 301 EYILENLERY VRNDIKFVDY ERREIRRRHQ VSEILYRYVC HSVSPVAPVA351 HQLMEANIVK TLATEYTYAA AQMLQKLLGA KGFERGHTAG NIAIDIRPFT 401IFEGPNDMLY AEIYDQFVRA TAEEKEAGMK LDKNQTLLDR LQTDARFAAV 451 ARDYTLPEDIRSFLQEHTLT DACALQKVFI GKIIARLFVF VQAKHEDTAA 501 FLLNDIRKDI LDCRYCG*m644/g644 94.6% identity in 517 aa overlap        10        20        30        40        50        60 m644.pepMPSERSADCCPAHFVVKFRKSTLNCGRRFDRPPINGNRQRKPMIHTEPSAQPSTMDTAAF||||| |||||:|||||||| ||||||||||||||||||||||||||||||||||||||| g644MPSERPADCCPVHFVVKFRKLTLNCGRRFDRPPINGNRQRKPMIHTEPSAQPSTMDTAAF        10        20        30        40        50        60        70        80        90       100       110       120 m644.pepLKHIESAFRRIFSDGIDLMRYLPEDKWLALKQAGLLLPFLDKKYGGRKGSQFEIQEVLRI|||||||| ||||||||||||||||||||||||||||||||||:|||||||||||||||| g644LKHIESAFPRIFSDGIDLMRYLPEDKWLALKQAGLLLPFLDKKHGGRKGSQFEIQEVLRI        70        80        90       100       110       120       130       140       150       160       170       180 m644.pepAGHYGVPVTLRTGIEGALVLQPLQEFGDEAQVAQGLEMIFKGEGGGLGVTEPETSGAAIA||||||||||||||||||||||||||| ||||||||:||||||:  |||||||||||||| g644AGHYGVPVTLRTGIEGALVLQPLQEFGGEAQVAQGLDMIFKGESRRLGVTEPETSGAAIA       130       140       150       160       170       180       190       200       210       220       230       240 m644.pepREMQSYYEYIDGQTIYVNAAKYWQGNSQSDFLLVAAKERKNGKLAKVIDLLLVPKTYIRC||||| ||| | |||||||||||||||||||||||||||||||||||||||||||||||| g644REMQSCYEYTDEQTIYVNAAKYWQGNSQSDFLLVAAKERKNGKLAKVIDLLLVPKTYIRC       190       200       210       220       230       240       250       260       270       280       290       300 m644.pepETLASEGLRAVRYAVNRIDAEMPATAVMKLSQSDAAGLRAFQNIFIRSRLQLIGMTHGIM|||||||||||||||||||||||||||||||::||||||||||||||||||||||||||| g644ETLASEGLRAVRYAVNRIDAEMPATAVMKLSRGDAAGLRAFQNIFIRSRLQLIGMTHGIM       250       260       270       280       290       300       310       320       330       340       350       360 m644.pepEYILENLERYVRNDIKFVDYERREIRRRHQVSEILYRYVCHSVSPVAPVAHQLMEANIVK||||:||:|||||||:|||||||||:|||||||||||||||||||||||||||||||||| g644EYILDNLNRYVRNDIRFVDYERREIQRRHQVSEILYRYVCHSVSPVAPVAHQLMEANIVK       310       320       330       340       350       360       370       380       390       400       410       420 m644.pepTLATEYTYAAAQMLQKLLGAKGFERGHTAGNIAIDIRPFTIFEGPNDMLYAEIYDQFVRA||||||||||||||||||||||||||| |||||||||||||||||||||||||||||||| g644TLATEYTYAAAQMLQKLLGAKGFERGHPAGNIAIDIRPFTIFEGPNDMLYAEIYDQFVRA       370       380       390       400       410       420       430       440       450       460       470       480 m644.pepTAEEKEAGMKLDKNQTLLDRLQTDARFAAVARDYTLPEDIRSFLQEHTLTDACALQKVFI||||||||:|||||||||| :|||:|||||||||:||||||||||||||||||||||||| g644TAEEKEAGIKLDKNQTLLDAVQTDVRFAAVARDYALPEDIRSFLQEHTLTDACALQKVFI       430       440       450       460       470       480       490       500       510 m644.pepGKIIARLFVFVQAKHEDTAAFLLNDIRKDILDCRYCGX|||||||||||| :||||:||||||||||||||||||| g644GKIIARLFVFVQEEHEDTTAFLLNDIRKDILDCRYCGX        490       500       510The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2073>:

a644.seq 1 ATGCCGTCTG AAAGGTCGGC GGATTGTTGC CCGGCGCACT TTGTGGTAAA 51GTTTAGAAAA TCAACTCTAA ACTGTGGCAG GCGGTTTGAC CGGCCGCCGA 101 TTAATGGGAACCGACAGAGG AAGCCGATGA TACACACCGA ACCGAGCGCG 151 CAGCCGTCAA CTATGGACACGGCTGCTTTT TTAAAGCACA TCGAATCCGC 201 ATTCCGCCGC ATTTTTGCAG ACGGTATCGACCTGATGCGA TACCTGCCCG 251 AAGACAAATG GCTTGCCTTG AAGCAGGCGG GTTTGCTGTTGCCCTTCCTC 301 GACAAAAAAT ACGGCGGGCG CAAGGGCAGC CAGTTTGAAA TTCAGGAAGT351 CTTGCGGATT GCGGGGCATT ACGGCGTGCC CGTTANNNNN NNNNNNNNNN 401NNGAAGGCGC GCTGGTGTTG CAGCCACTGC AAGAGTTCGG CGATGAAGCG 451 CAAATCGCACAGGGTTTGGA CATGGTTTTC AAAGGCGAGG GCGGCGGTTT 501 AGGCGTTACC GAACCCGAAACCTCCGGCGC GGCGATTGCC CGAGAAATGC 551 AGTCTTACTA CGAATATACC GACGGACAAACCATTTACGT CAACGCCGCG 601 AAATACTGGC AGGGCAACTC GCAAAGCGAC TTCCTCCTCGTTGCCGCCAA 651 AGAGCGCAAA AACGGCAAAC TCGCCAAAGT CATCGACCTG CTGCTCGTCC701 CCAAAACATA CATCCGCTGC GAAACCCTCG CATCCGAAGG CTTGCGCGCC 751GTCCGTTACG CCGTCAACCG CATCGATGCC GAAATGCCTG CAACCGCCGT 801 GATGAAACTCTCCCAGAGCG ACGCTGCCGG TTTGCGCGCG TTCCAAAACA 851 TCTTTATCCG CAGCCGCCTGCAACTGATCG GCATGACGCA CGGCATTATG 901 GAATACACCC TTGAAAACCT GGAACGATACGTCCGCAACG ACATCAGATT 951 CGTCGATTAC GAACGCCGCG AAATCCGGCG CCGCCATCAGGTTTCCGAGA 1001 TTCTTTACCG CTACGTCTGC CATTCCGTTT CGCCCGTTGC ACCCGTCGCC1051 CATCAACTGA TGGAGGCGAA CATCGTCAAA ACCCTCGCCA CGGAATACAC 1101TTACGCCGCC GCGCAAATGT TGCAAAAACT CTTGGGCGCG AAGGGTTTTG 1151 AACGCGGACACACCGCCGGC AATATCGCTA TCGACATCCG CCCCTTCACG 1201 ATTTTTGAAG GCCCGAACGATATGCTTTAT GCCGAAATTT ACGACCAGTT 1251 TGTCCGCGCC ACCGCCGAAG AAAAAGAAGCAGGCATGAAG TTGGACAAAA 1301 ACCAAACCCT GCTCGACCGC CTGCAAACCG ATGCCCGCTTTGCCGCCGTC 1351 GCCCGCGACT ACACTTTGCC CGAAGACATC CGCAGCTTCC TGCAGGAACA1401 CACCCTGACC GATGCCTGCG CCCTGCAAAA AGTCTTTATC GGCAAAATCA 1451TCGCCCGACT CTTTGTCTTC GTACAGGCGG AACACGAAGA CACCGCAGCC 1501 TTCCTGCTGAACGACATCCG CAAAGACATA TTGGACTGCC GATATTGCGG 1551 ATAGThis corresponds to the amino acid sequence <SEQ ID 2074; ORF 644.a>:

a644.pep 1 MPSERSADCC PAHFVVKFRK STLNCGRRFD RPPINGNRQR KPMIHTEPSA 51QPSTMDTAAF LKHIESAFRR IFADGIDLMR YLPEDKWLAL KQAGLLLPFL 101 DKKYGGRKGSQFEIQEVLRI AGHYGVPVXX XXXXEGALVL QPLQEFGDEA 151 QIAQGLDMVF KGEGGGLGVTEPETSGAAIA REMQSYYEYT DGQTIYVNAA 201 KYWQGNSQSD FLLVAAKERK NGKLAKVIDLLLVPKTYIRC ETLASEGLRA 251 VRYAVNRIDA EMPATAVMKL SQSDAAGLRA FQNIFIRSRLQLIGMTHGIM 301 EYTLENLERY VRNDIRFVDY ERREIRRRHQ VSEILYRYVC HSVSPVAPVA351 HQLMEANIVK TLATEYTYAA AQMLQKLLGA KGFERGHTAG NIAIDIRPFT 401IFEGPNDMLY AEIYDQFVRA TAEEKEAGMK LDKNQTLLDR LQTDARFAAV 451 ARDYTLPEDIRSFLQEHTLT DACALQKVFI GKIIARLFVF VQAEHEDTAA 501 FLLNDIRKDI LDCRYCG*m644/a644 97.3% identity in 517 aa overlap        10        20        30        40        50        60 m644.pepMPSERSADCCPAHFVVKFRKSTLNCGRRFDRPPINGNRQRKPMIHTEPSAQPSTMDTAAF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a644MPSERSADCCPAHFVVKFRKSTLNCGRRFDRPPINGNRQRKPMIHTEPSAQPSTMDTAAF        10        20        30        40        50        60        70        80        90       100       110       120 m644.pepLKHIESAFRRIFSDGIDLMRYLPEDKWLALKQAGLLLPFLDKKYGGRKGSQFEIQEVLRI||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| a644LKHIESAFRRIFADGIDLMRYLPEDKWLALKQAGLLLPFLDKKYGGRKGSQFEIQEVLRI        70        80        90       100       110       120       130       140       150       160       170       180 m644.pepAGHYGVPVTLRTGIEGALVLQPLQEFGDEAQVAQGLEMIFKGEGGGLGVTEPETSGAAIA||||||||:  :  |||||||||||||||||:||||:|:||||||||||||||||||||| a644AGHYGVPVXXXXXXEGALVLQPLQEFGDEAQIAQGLDMVFKGEGGGLGVTEPETSGAAIA       130       140       150       160       170       180       190       200       210       220       230       240 m644.pepREMQSYYEYIDGQTIYVNAAKYWQGNSQSDFLLVAAKERKNGKLAKVIDLLLVPKTYIRC||||||||| |||||||||||||||||||||||||||||||||||||||||||||||||| a644REMQSYYEYTDGQTIYVNAAKYWQGNSQSDFLLVAAKERKNGKLAKVIDLLLVPKTYIRC       190       200       210       220       230       240       250       260       270       280       290       300 m644.pepETLASEGLRAVRYAVNRIDAEMPATAVMKLSQSDAAGLRAFQNIFIRSRLQLIGMTHGIM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a644ETLASEGLRAVRYAVNRIDAEMPATAVMKLSQSDAAGLRAFQNIFIRSRLQLIGMTHGIM       250       260       270       280       290       300       310       320       330       340       350       360 m644.pepEYILENLERYVRNDIKFVDYERREIRRRHQVSEILYRYVCHSVSPVAPVAHQLMEANIVK|| ||||||||||||:|||||||||||||||||||||||||||||||||||||||||||| a644EYTLENLERYVRNDIRFVDYERREIRRRHQVSEILYRYVCHSVSPVAPVAHQLMEANIVK       310       320       330       340       350       360       370       380       390       400       410       420 m644.pepTLATEYTYAAAQMLQKLLGAKGFERGHTAGNIAIDIRPFTIFEGPNDMLYAEIYDQFVRA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a644TLATEYTYAAAQMLQKLLGAKGFERGHTAGNIAIDIRPFTIFEGPNDMLYAEIYDQFVRA       370       380       390       400       410       420       430       440       450       460       470       480 m644.pepTAEEKEAGMKLDKNQTLLDRLQTDARFAAVARDYTLPEDIRSFLQEHTLTDACALQKVFI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a644TAEEKEAGMKLDKNQTLLDRLQTDARFAAVARDYTLPEDIRSFLQEHTLTDACALQKVFI       430       440       450       460       470       480       490       500       510 m644.pepGKIIARLFVFVQAKHEDTAAFLLNDIRKDILDCRYCGX|||||||||||||:|||||||||||||||||||||||| a644GKIIARLFVFVQAEHEDTAAFLLNDIRKDILDCRYCGX        490       500       510The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2075>:

g645.seq 1 ATGATGATGG TGTTGGCGTT GGGGATGTCG ATGCCGGTTT CGATGATGGT 51GGAACAGAGC AACACATTGA ATCTTTGCTG CAAAAAGTCG CGCATGACTT 101 GTTCCAGCTCGCGCTCACGC AGTTGTCCGT GCGCCACGCC GATACGGGCT 151 TCGGGCAGCA GGGTTTCCAGCCGCTCGCGC ATATTCTCAA TCGTATCTAC 201 TTCATTGTGC AGGAAAAata cCTGTCCTCCGCGTTTGAGT TCGCGCAACA 251 CGGCTTCGCG CACGCTGCCT TCGCTGAACG GTTTGACAAAGGTTTTCACG 301 GCGAGGCGGC GGCTCGGTGC AGTGGTAATC AGCGAGAAGT CGCGCAGACC351 TTCGAGCGCC ATGCTGAGGG TGCGCGGAAT CGGCGTGGCG GTCATGGTTA 401GGATGTCGAC ATTGGCGCGC AGGCGTTTGA GCTGCTCTTT CTGTCGCACG 451 CCGAAGCGGTGTTCTTCATC GATAATCAAT AAACCTAAGT TTTTGAATTT 501 TATGTCGTCC TGCACCAATTTGTGCGTACC GATAACGATA TCGACAGTAC 551 CGTCCGCCAT GCCTTCGAGC GTGGCTTTGGTGGCTTTGCT GTTGTTGAAA 601 CGCGAAAGGC TGGCGACTTT CACGGGGAAA TCGGCGAAACGGTCGGCGAA 651 GTTTTGCGCG TGCTGCTCGA CCAGAAGCGT GGTCGGGGCG AGTACGGCGA701 CCTGTTTGCC GCCCATCACC GCCACAAACG CGGCGCGAAG GGCGACTTCG 751GTTTTGCCGA AACCGACATC GCCGCACACA AGTCGGTCCA TCGGCTTCGC 801 CTGCGTCAAATCTTTAATCA CGGcggcgat ggcggcggcC TGGTCTTCGG 851 TTTCCTCGTA GThis corresponds to the amino acid sequence <SEQ ID 2076; ORF 645.ng>:

g645.pep 1 MMMVLALGMS MPVSMMVEQS NTLNLCCKKS RMTCSSSRSR SCPCATPIRA 51SGSRVSSRSR IFSIVSTSLC RKNTCPPRLS SRNTASRTLP SLNGLTKVFT 101 ARRRLGAVVISEKSRRPSSA MLRVRGIGVA VMVRMSTLAR RRLSCSFCRT 151 PKRCSSSIIN KPKFLNFMSSCTNLCVPITI STVPSAMPSS VALVALLLLK 201 RERLATFTGK SAKRSAKFCA CCSTRSVVGASTATCLPPIT ATNAARRATS 251 VLPKPTSPHT SRSIGFACVK SLITAAMAAA WSSVSS*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2077>:

m645.seq 1 ATGATGATGG TGTTGGCGTT GGGGATATCG ATACCGGTTT CGATGATGGT 51GGAACAGAGC AACACGTTAA ATCGTTGCTG CAAAAAGTCG CGCATGACTT 101 GTTCCAGCTCGCGCTCGCGC AGTTGTCCGT GCGCCACGCC GATGCGGGCT 151 TCGGGCAGCA GGGTTTCCAGCCGCTCGCGC ATATTTTCAA TCGTATCTAC 201 TTCATTGTGC AGGAAAAATA CCTGTCCTCCGCGTTTGAGT TCGCGCAACA 251 CGGCTTCGCG CACGCTGCCT TCGCTAAAGG GTTTGACAAAGGTTTTGACG 301 GCGAGGCGGC GGCTGGGCGC GGTGGTAATC AGCGAGAAGT CGCGCAGTCC351 TTCCAACGCC ATACTTAAAG TACGCGGAAT CGGCGTGGCG GTCATGGTAA 401GGATATCAAC ATTGGCGCGC AGGCGTTTGA GCTGCTCTTT CTGACGCACG 451 CCGAAGCGGTGTTCTTCGTC GATAATCACT AAACCTAAGT TTTTGAATTT 501 GATGTCGTCC TGCACCAGTTTGTGCGTACC GATAACAATA TCGACCGTGC 551 CGTCTGCCAT GCCTTCCAGC GCGGCTTTGGTGGCTTTGCT GTTGTTGAAA 601 CGCGAAAGGC TGGCGACTTT CACGGGGAAA TCGGCGAAACGGTCGGCGAA 651 GTTTTGCGCG TGCTGCTCGA CCAAAAGCGT GGTCGGAGCA AGTACGGCGA701 CCTGTTTGCC GCCCATCACC GCCACAAACG CGGCGCGCAG GGCGACTTCG 751GTTTTGCCGA AGCCGACATC GCCGCACACA AGGCGATCCA TCGGCTTCGC 801 TTGCGTCAAATCTTTAATCA CGGCGGCGAT GGCGGCGGCC TGGTCTTCGG 851 TTTCCTCGTA GThis corresponds to the amino acid sequence <SEQ ID 2078; ORF 645>:

m645.pep 1 MMMVLALGIS IPVSMMVEQS NTLNRCCKKS RMTCSSSRSR SCPCATPMRA 51SGSRVSSRSR IFSIVSTSLC RKNTCPPRLS SRNTASRTLP SLKGLTKVLT 101 ARRRLGAVVISEKSRSPSNA ILKVRGIGVA VMVRISTLAR RRLSCSF*RT 151 PKRCSSSIIT KPKFLNLMSSCTSLCVPITI STVPSAMPSS AALVALLLK 201 RERLATFTGK SAKRSAKFCA CCSTKSVVGASTATCLPPIT ATNAARRATS 251 VLPKPTSPHT RRSIGFACVK SLITAAMAAA WSSVSS*m645/g645 93.7% identity in 286 aa overlap        10        20        30        40        50        60 m645.pepMMMVLALGISIPVSMMVEQSNTLNRCCKKSRMTCSSSRSRSCPCATPMRASGSRVSSRSR||||||||:|:||||||||||||| ||||||||||||||||||||||:|||||||||||| g645MMMVLALGMSMPVSMMVEQSNTLNLCCKKSRMTCSSSRSRSCPCATPIRASGSRVSSRSR        10        20        30        40        50        60        70        80        90       100       110       120 m645.pepIFSIVSTSLCRKNTCPPRLSSRNTASRTLPSLKGLTKVLTARRRLGAVVISEKSRSPSNA||||||||||||||||||||||||||||||||:|||||:|||||||||||||||| ||:| g645IFSIVSTSLCRKNTCPPRLSSRNTASRTLPSLNGLTKVFTARRRLGAVVISEKSRRPSSA        70        80        90       100       110       120       130       140       150       160       170       180 m645.pepILKVRGIGVAVMVRISTLARRRLSCSFXRTPKRCSSSIITKPKFLNLMSSCTSLCVPITI:|:|||||||||||:|||||||||||| |||||||||||:||||||:|||||:||||||| g645MLRVRGIGVAVMVRMSTLARRRLSCSFCRTPKRCSSSIINKPKFLNFMSSCTNLCVPITI       130       140       150       160       170       180       190       200       210       220       230       240 m645.pepSTVPSAMPSSAALVALLLLKRERLATFTGKSAKRSAKFCACCSTKSVVGASTATCLPPIT||||||||||:|||||||||||||||||||||||||||||||||:||||||||||||||| g645STVPSAMPSSVALVALLLLKRERLATFTGKSAKRSAKFCACCSTRSVVGASTATCLPPIT       190       200       210       220       230       240       250       260       270       280 m645.pepATNAARRATSVLPKPTSPHTRRSIGFACVKSLITAAMAAAWSSVSSX|||||||||||||||||||| |||||||||||||||||||||||||| g645ATNAARRATSVLPKPTSPHTSRSIGFACVKSLITAAMAAAWSSVSSX       250       260       270       280The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2079>:

a645.seq 1 ATGATGATGG TGTTGGCGTT GGGAATGTCG ATACCGGTTT CGATGATGGT 51GGAACAGAGC AACACGTTAA ATCGTTGCTG CAAAAAGTCG CGCATGACTT 101 GTTCCAGCTCGCGCTCGCGC AGTTGTCCGT GCGCCACGCC GATGCGGGCT 151 TCGGGCAGCA GGGTTTCCAGCCGCTCACGC ATGTTTTCGA TGGTATCCAC 201 TTCATTGTGC AGGAAAAATA CTTGCCCGCCGCGTTTGAGT TCGCGCAATA 251 CGGCTTCGCG CACGCTGCCT TCGCTGAACG GTTTGACAAAGGTTTTGACG 301 GCGAGGCGGC GGCTGGGCGC AGTGGTAATC AGCGAGAAGT CGCGCAGTCC351 TTCCAGCGCC ATACTTAAAG TACGCGGAAT CGGCGTAGCG GTCATGGTAA 401GGATGTCGAC ATTGGCGCGC AGGCGTTTGA GCTGCTCTTT CTGACGCACG 451 CCGAAGCGGTGTTCTTCGTC GATAATCACT AAACCTACGT TTTTGAATTT 501 TATGTCGTCC TGCACCAGTTTGTGCGTACC GATAACAATA TCGACCGTGC 551 CGTCCGCCAT GCCTTCCAGC GCGGCTTTGGTGGCTTTGCT GTTGTTGAAA 601 CGCGAAAGGC TGGCGACTTT CACGGGGAAA TCGGCGAAGCGGTCGGCAAA 651 ATTTTGCGCG TGCTGCTCGA CCAGAAGCGT GGTCGGTGCG AGTACGGCAA701 CTTGTTTGCC ACCCATTACC GCCACAAACG CGGCGCGCAG GGCGACTTCG 751GTTTTGCCGA AACCGACATC GCCGCACACG AGGCGGTCCA TCGGCTTCGC 801 CTGCGTCAAATCTTTAATCA CGGCGGCGAT GGCGGCTGCC TGGTCTTCGG 851 TTTCTTCGTA GThis corresponds to the amino acid sequence <SEQ ID 2080; ORF 645.a>:

a645.pep 1 MMMVLALGMS IPVSMMVEQS NTLNRCCKKS RMTCSSSRSR SCPCATPMRA 51SGSRVSSRSR MFSMVSTSLC RKNTCPPRLS SRNTASRTLP SLNGLTKVLT 101 ARRRLGAVVISEKSRSPSSA ILKVRGIGVA VMVRMSTLAR RRLSCSF*RT 151 PKRCSSSIIT KPTFLNFMSSCTSLCVPITI STVPSAMPSS AALVALLLLK 201 RERLATFTGK SAKRSAKFCA CCSTRSVVGASTATCLPPIT ATNAARRATS 251 VLPKPTSPHT RRSIGFACVK SLITAAMAAA WSSVSS*m645/a645 96.9% identity in 286 aa overlap        10        20        30        40        50        60 m645.pepMMMVLALGISIPVSMMVEQSNTLNRCCKKSRMTCSSSRSRSCPCATPMRASGSRVSSRSR||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||| a645MMMVLALGMSIPVSMMVEQSNTLNRCCKKSRMTCSSSRSRSCPCATPMRASGSRVSSRSR        10        20        30        40        50        60        70        80        90       100       110       120 m645.pepIFSIVSTSLCRKNTCPPRLSSRNTASRTLPSLKGLTKVLTARRRLGAVVISEKSRSPSNA:||:||||||||||||||||||||||||||||:|||||||||||||||||||||||||:| a645MFSMVSTSLCRKNTCPPRLSSRNTASRTLPSLNGLTKVLTARRRLGAVVISEKSRSPSSA        70        80        90       100       110       120       130       140       150       160       170       180 m645.pepILKVRGIGVAVMVRISTLARRRLSCSFXRTPKRCSSSIITKPKFLNLMSSCTSLCVPITI||||||||||||||:||||||||||||||||||||||||||| |||:||||||||||||| a645ILKVRGIGVAVMVRMSTLARRRLSCSFXRTPKRCSSSIITKPTFLNFMSSCTSLCVPITI       130       140       150       160       170       180       190       200       210       220       230       240 m645.pepSTVPSAMPSSAALVALLLLKRERLATFTGKSAKRSAKFCACCSTKSVVGASTATCLPPIT||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||| a645STVPSAMPSSAALVALLLLKRERLATFTGKSAKRSAKFCACCSTRSVVGASTATCLPPIT       190       200       210       220       230       240       250       260       270       280 m645.pepATNAARRATSVLPKPTSPHTRRSIGFACVKSLITAAMAAAWSSVSSX||||||||||||||||||||||||||||||||||||||||||||||| a645ATNAARRATSVLPKPTSPHTRRSIGFACVKSLITAAMAAAWSSVSSX       250       260       270       280The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2081>:

g647.seq 1 ATGCAAAGGC TCGCCGCAGA CGGCATCCAA ATCTTTTTTG TAGGTGTCGA 51TGGGCAGTTT GCCTTGCGAA TAAACGGTTT GGTTAAAGAG CGTGCACGCT 101 CCGTATTCTTTGGCAAGGTT TGCCGATGCT TTGAGCAGGT AATACTGTAT 151 GGCTTCAAAG GTACGGTGGGTCAGACCGAG CGCGGAACCG TCGCTGTAGC 201 GGACACCGTT TTTCGCCAGA TAGTAGGCGTAGTTGATGAC ACCGATGCCG 251 AGCGAACGGC GGTCCATAGT AGAGGTACGC GCGGCTTCTACCGGATATCC 301 CTGATAATCT AAThis corresponds to the amino acid sequence <SEQ ID 2082; ORF 647.ng>:

g647.pep 1 MQRLAADGIQ IFFVGVDGQF ALRINGLVKE RARSVFFGKV CRCFEQVILY 51GFKGTVGQTE RGTVAVADTV FRQIVGVVDD TDAERTAVHS RGTRGFYRIS 101 LII*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2083>:

m647.seq 1 ATGCAAAGGC TCGCCGCAGA CGGCATCCAA ATCTTTTTTG TAAGTGTCGA 51TGGGCAGTTT GCCTTGCGAA TAAACGGTTT GGTTAAAGAG CGTGCACGCA 101 CCGTATTCTTTGGCAAGGTT TGCCGATGCT TTGAGCAGGT AATACTGTAT 151 GGCTTCAAAG GTACGGTGGGTCAGACCGAG CGCGGAACCG TCGCTGTAGC 201 GGACACCGTT TTTCGCCAGA TAATAAGCATAGTTAATCAC GCCGATGCCG 251 AGCGAACGGC GGCCCATAGT AGAGGTACGC GCGGCTTCTACCGGATATCC 301 CTGATAATCT AAThis corresponds to the amino acid sequence <SEQ ID 2084; ORF 647>:

m647.pep 1 MQRLAADGIQ IFFVSVDGQF ALRINGLVKE RARTVFFGKV CRCFEQVILY 51GFKGTVGQTE RGTVAVADTV FRQIISIVNH ADAERTAAHS RGTRGFYRIS 101 LII*m647/g647 91.3% identity in 103 aa overlap        10        20        30        40        50        60 m647.pepMQRLAADGIQIFFVSVDGQFALRINGLVKERARTVFFGKVCRCFEQVILYGFKGTVGQTE||||||||||||||:||||||||||||||||||:|||||||||||||||||||||||||| g647MQRLAADGIQIFFVGVDGQFALRINGLVKERARSVFFGKVCRCFEQVILYGFKGTVGQTE        10        20        30        40        50        60        70        80        90       100 m647.pepRGTVAVADTVFRQIISIVNHADAERTAAHSRGTRGFYRISLIIX ||||||||||||||:::|::||||||:|||||||||||||||| g647RGTVAVADTVFRQIVGVVDDTDAERTAVHSRGTRGFYRISLIIX        70        80        90       100The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2085>:

a647.seq 1 GTGCAAAGGC TCGTTACACA CAGCGTCCAA GTCTTTTTTG TAGGTGTCGA 51TGGGCAGTTT GCCTTGCGAA TAAACGGTTT GGTTAAAGAG CGTGCACGCA 101 CCGTATTCTTTGGCAAGGTT TGCCGATGCT TTGAGCAGGT AATACTGTAT 151 GGCTTCAAAG GTACGGTGGGTCAGACCGAG CGCGGAGCCG TCGCTGTAGC 201 GGACACCGTT TTTCGCCAAA TAATACGCATAGTTGATCAC GCCGATACCG 251 AGCGAACGGC GGCCCATAGT GGAGGTACGC GCGGCTTCTACCGGATATCC 301 CTGATAATCT AAThis corresponds to the amino acid sequence <SEQ ID 2086; ORF 647.a>:

a647.pep 1 VQRLVTHSVQ VFFVGVDGQF ALRINGLVKE RARTVFFGKV CRCFEQVILY 51GFKGTVGQTE RGAVAVADTV FRQIIRIVDH ADTERTAAHS GGTRGFYRIS 101 LII*m647/a647 87.4% identity in 103 aa overlap        10        20        30        40        50        60 m647.pepMQRLAADGIQIFFVSVDGQFALRINGLVKERARTVFFGKVCRCFEQVILYGFKGTVGQTE :|||::::|:|||:||||||||||||||||||||||||||||||||||||||||||||| a647VQRLVTHSVQVFFVGVDGQFALRINGLVKERARTVFFGKVCRCFEQVILYGFKGTVGQTE        10        20        30        40        50        60        70        80        90       100 m647.pepRGTVAVADTVFRQIISIVNHADAERTAAHSRGTRGFYRISLIIX||:|||||||||||| ||:|||:||||||| ||||||||||||| a647RGAVAVADTVFRQIIRIVDHADTERTAAHSGGIRGFYRISLIIX        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2087>:

g648.seq 1 ATGAACAGGC GCAACGCGCG GATCGAACGG GCTGTGCGTA TTGCAGTGAT 51CGACGTTTTG AATGTAGATG CGCCCGGTCC CGGCACGCTC CTGCATCAGC 101 GTGGAAAACAGGTCGGCAGC CGGAATGATA CGCTTGCGTA TGTTCGGGTC 151 TTGCTCGTAT TTCGTATAGAGCCGCTCAAA TTCGTCTTGG TCGGCAAAAA 201 ACGCTTCGTA CAACCCCGAA ACCTCGTTGGGCGAAAACAG CGTAATGTTG 251 CCGCCCTTAA TCAGGCGGGT GTACAGCAGG CGGTTGATTTGCACGCCATA 301 ATCAAGCTGG CGGATACGGT TGTCTTCCAC GCCCCGGTTG TTTTTCAACA351 CCAGCAGGCT TTCGGCTTCA ATATGCCACA AGGGGTAGAA CAAGGTTGCC 401GCGCCGCCGC GCACGCCACC TTGCGAACAA GATTTGACCG CCGCCTGAAA 451 CATCTTAAAGAAGGGAATGC AGCCGGTATG CCGGGCTTCA CCGCCCCGGA 501 TTTCGCTGTC CAGCCCGCGGATACGTCCGG CATTGATGCC GATGCCCGCG 551 CGTTGGGAAA CGTATTTCAC AATCGCGCTGGTAGTGGCAT TGATGGAATC 601 CAAACTATCG TCGCATTCAA TCAGCACACA GCTTGAThis corresponds to the amino acid sequence <SEQ ID 2088; ORF 648.ng>:

g648.pep 1 MNRRNARIER AVRIAVIDVL NVDAPGPGTL LHQRGKQVGS RNDTLAYVRV 51LLVFRIEPLK FVLVGKKRFV QPRNLVGRKQ RNVAALNQAG VQQAVDLHAI 101IKLADTVVFH APVVFQHQQA FGFNMPQGVE QGCRAAAHAT LRTRFDRRLK 151 HLKEGNAAGMPGFTAPDFAV QPADTSGIDA DARALGNVFH NRAGSGIDGI 201 QTIVAFNQHT A*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2089>:

m648.seq 1 ATGAACAGGC GCGACGCGCG GATCGAACGG GCTGTGCGTA TTGCAGTGAT 51CGACGTTTTG AATGTAGATG CGCCCGGTTC CGGCACGCTC CTGCATCAGC 101 GTGGAAAACAGGTCGGCAGC CGGAATGATG CGCTTGCGGA TATCAGGGTC 151 TTGCTCGTAT TTCGTATAGAGCCGCTCAAA TTCGTCTTGG TCGGCAAAAA 201 ACGCTTCGTA CAATCCCGGA ACCTCGTTGGGCGAAAACAG CGTAATGTTG 251 CCGCCCTTAA TCAGGCGGGT GTACAGCAGG CGGTTGATTTGCACGCCGTA 301 ATCAAGCTGA CGGATACGGT TGTCTTCCAC ACCGCGGTTG TTTTTCAACA351 CCAGCAGGCT TTCGGCTTCG ATATGCCACA AGGGGTAGAA CAAGGTTGCC 401GCGCCGCCGC GCACGCCGCC TTGCGAACAG GATTTGACCG CCGCCTGAAA 451 CATTTTAAAGAAGGGAATGC AGCCGGTATG CCGCGCTTCG CCGCCCCGGA 501 TTTCGCTGTC CAAACCGCGGATACGTCCGG CATTGATGCC GATGCCCGCA 551 CGCTGGGAAA CGTATTTCAC AATCGCGCTGGTAGTGGCAT TGATGGAATC 601 CAAACTATCG TCGCATTCAA TCAGCACACA GCTTGAThis corresponds to the amino acid sequence <SEQ ID 2090; ORF 648>:

m648.pep 1 MNRRDARIER AVRIAVIDVL NVDAPGSGTL LHQRGKQVGS RNDALADIRV 51LLVFRIEPLK FVLVGKKRFV QSRNLVGRKQ RNVAALNQAG VQQAVDLHAV 101IKLTDTVVFH TAVVFQHQQA FGFDMPQGVE QGCRAAAHAA LRTGFDRRLK 151 HFKEGNAAGMPRFAAPDFAV QTADTSGIDA DARTLGNVFH NRAGSGIDGI 201 QTIVAFNQHT A* m648/g64891.5% identity in 211 aa overlap        10        20        30        40        50        60 m648.pepMNRRDARIERAVRIAVIDVLNVDAPGSGTLLHQRGKQVGSRNDALADIRVLLVFRIEPLK||||:|||||||||||||||||| |||||||||||||||||||:|| :|||||||||||| g648MNRRNARIERAVRIAVIDVLNVDAPGPGTLLHQRGKQVGSRNDTLAYVRVLLVFRIEPLK        10        20        30        40        50        60        70        80        90       100       110       120 m648.pepFVLVGKKRFVQSRNLVGRKQRNVAALNQAGVQQAVDLHAVIKLTDTVVFHTAVVFQHQQA||||||||||| |||||||||||||||||||||||||||:|||:||||||: |||||||| g648FVLVGKKRFVQPRNLVGRKQRNVAALNQAGVQQAVDLHAIIKLADTVVFHAPVVFQHQQA        70        80        90       100       110       120       130       140       150       160       170       180 m648.pepFGFDMPQGVEQGCRAAAHAALRTGFDRRLKHFKEGNAAGMPRFAAPDFAVQTADTSGIDA|||:|||||||||||||||:||| |||||||:||||||||| |:||||||| |||||||| g648FGFNMPQGVEQGCRAAAHATLRTRFDRRLKHLKEGNAAGMPGFTAPDFAVQPADTSGIDA       130       140       150       160       170       180       190       200       210 m648.pep DARTLGNVFHNRAGSGIDGIQTIVAFNQHTAX|||:|||||||||||||||||||||||||||| g648 DARALGNVFHNRAGSGIDGIQTIVAFNQHTAX       190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2091>:

a648.seq 1 ATGAACAGGC GCAACGCGCG GATCGAACGG GCTGTGCGTA TTGCAGTGAT 51CGACGTTTTG AATGTAGATG CGCCCGGTTC CGGCACGCTC CTGCATCAGC 101 GTGGAAAACAGGTCGGCAGC CGGAATGATG CGCTTGCGGA TATCAGGGTC 151 TTGCTCGTAT TTCGTATAGAGCCGCTCAAA TTCGTCTTGG TCGGCAAAAA 201 ACGCTTCGTA CAATCCCGGA ACCTCGTTGGGCGAAAACAG CGTAATGTTG 251 CCGCCCTTAA TCAGGCGGGT GTACAGCAGG CGGTTGATTTGCACGCCGTA 301 ATCAAGCTGA CGGATACGGT TGTCTTCCAC GCCCCGGTTG TTTTTCAACA351 CCAGCAGGCT TTCGGCTTCG ATATGCCACA AGGGGTAGAA CAAGGTTGCC 401GCGCCGCCGC GCACGCCACC TTGCGAACAG GATTTGACTG CCGCCTGAAA 451 CATTTTAAAGAAGGGAATGC AGCCGGTATG CCGTGCTTCG CCGCCCCGGA 501 TTTCGCTGTC CAGTCCGCGGATACGTCCGG CATTGATGCC GATGCCCGCA 551 CGCTGGGAAA CGTATTTCAC AATCGCGCTGGTAGTGGCGT TGATGGAATC 601 CAGGCTGTCG TCGCATTCGA TCAATACGCA GCTTGAThis corresponds to the amino acid sequence <SEQ ID 2092; ORF 648.a>:

a648.pep 1 MNRRNARIER AVRIAVIDVL NVDAPGSGTL LHQRGKQVGS RNDALADIRV 51LLVFRIEPLK FVLVGKKRFV QSRNLVGRKQ RNVAALNQAG VQQAVDLHAV 101 IKLTDTVVFHAPVVFQHQQA FGFDMPQGVE QGCRAAAHAT LRTGFDCRLK 151 HFKEGNAAGM PCFAAPDFAVQSADTSGIDA DARTLGNVFH NRAGSGVDGI 201 QAVVAFDQYA A* m648/a648 93.8%identity in 211 aa overlap        10        20        30        40        50        60 m648.pepMNRRDARIERAVRIAVIDVLNVDAPGSGTLLHQRGKQVGSRNDALADIRVLLVFRIEPLK||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||| a648MNRRNARIERAVRIAVIDVLNVDAPGSGTLLHQRGKQVGSRNDALADIRVLLVFRIEPLK        10        20        30        40        50        60        70        80        90       100       110       120 m648.pepFVLVGKKRFVQSRNLVGRKQRNVAALNQAGVQQAVDLHAVIKLTDTVVFHTAVVFQHQQA||||||||||||||||||||||||||||||||||||||||||||||||||: |||||||| a648FVLVGKKRFVQSRNLVGRKQRNVAALNQAGVQQAVDLHAVIKLTDTVVFHAPVVFQHQQA        70        80        90       100       110       120       130       140       150       160       170       180 m648.pepFGFDMPQGVEQGCRAAAHAALRTGFDRRLKHFKEGNAAGMPRFAAPDFAVQTADTSGIDA|||||||||||||||||||:|||||| |||||||||||||| |||||||||:|||||||| a648FGFDMPQGVEQGCRAAAHATLRTGFDCRLKHFKEGNAAGMPCFAAPDFAVQSADTSGIDA       130       140       150       160       170       180       190       200       210 m648.pep DARTLGNVFHNRAGSGIDGIQTIVAFNQHTAX||||||||||||||||:||||::|||:|::|| a648 DARTLGNVFHNRAGSGVDGIQAVVAFDQYAAX       190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2093>:

g649.seq 1 ATGCTTGCCA TACTGTTGTC TGCAATACTG GGACTGGTAT CAACAACTGC 51CGCTGCCGGT ACGTCAGAAC CCGCCCACCG ACATACCAAA CATATCAGCA 101 AGGCAAACAAGCAGATGCTG CACCCCGAAT GCAGGAAATA TTTGGAACGC 151 CGTGCCGCGT GGTACCGATCGCAAGGCAAC GTGCAGGAAT TGCGCGAAAA 201 CAAAAAGGCG CGCAAAGCAT TCCGCACCCTGCCTTATGCG GAACAGAAAA 251 TCCAATGCCG GGCGGCTTAT GAGGCTTTCG ATGATTTCGACGGCGGCAGG 301 TTCCGCCGTT AAThis corresponds to the amino acid sequence <SEQ ID 2094; ORF 649.ng>:

g649.pep 1 MLAILLSAIL GLVSTTAAAG TSEPAHRHTK HISKANKQML HPECRKYLER 51RAAWYRSQGN VQELRENKKA RKAFRTLPYA EQKIQCRAAY EAFDDFDGGR 101 FRR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2095>:

m649.seq 1 ATGCTTGCCA TACTGTTGTC TGCAATATTG GGACTGGTAT CGACAACTGC 51CGCTGCCGGT ACGTCAGAAC CCGCCCACCG CGATACCAAA CATATCCGCA 101 AGGCAAACAAGCAGATGCTG CACCCCGAAT GCAGGAAATA TTTGGAACGC 151 CGTGCCGCGT GGTACCGATCGCAAGGCAAC GTGCAGGAAT TGCGCGAAAA 201 CAAAAAGGCG CGCAAAGCAT TCCGCTCCCTGCCTTATGCG GAACAGAAAA 251 TCCAATGCCG GGCGGCTTAT GAGGCTTTCG ATGATTTCGACGGCGGCAGT 301 TTCCGCCGTT AAThis corresponds to the amino acid sequence <SEQ ID 2096; ORF 649>:

m649.pep 1 MLAILLSAIL GLVSTTAAAG TSEPAHRDTK HIRKANKQML HPECRKYLER 51RAAWYRSQGN VQELRENKKA RKAFRSLPYA EQKIQCRAAY EAFDDFDGGS 101 FRR*m649/g649 96.1% identity in 103 aa overlap        10        20        30        40        50        60 m649.pepMLAILLSAILGLVSTTAAAGTSEPAHRDTKHIRKANKQMLHPECRKYLERRAAWYRSQGN||||||||||||||||||||||||||| |||| ||||||||||||||||||||||||||| g649MLAILLSAILGLVSTTAAAGTSEPAHRHTKHISKANKQMLHPECRKYLERRAAWYRSQGN        10        20        30        40        50        60        70        80        90       100 m649.pepVQELRENKKARKAFRSLPYAEQKIQCRAAYEAFDDFDGGSFRRX|||||||||||||||:||||||||||||||||||||||| |||| g649VQELRENKKARKAFRTLPYAEQKIQCRAAYEAFDDFDGGRFRRX        70        80        90       100The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2097>:

a649.seq 1 ATGCTTGCCA TACTGTTGTC TGCAATATTG GGACTGGTAT CGACAACTGC 51CGCTGCCGGT ACGTCAGAAC CCGCCCACCG CGATACCAAA CATATCCGCA 101 AGGCAAACAAGCAGATGCTG CACCCCGAAT GCAGGAAATA TTTGGAACGC 151 CGTGCCGCGT GGTACCGATCGCAAGGCAAC GTGCAGGAAT TGCGCGAAAA 201 CAAAAAGGCG CGCAAAGCAT TCCGCTCCCTGCCTTATAAG GAACAGAAAA 251 CCCAATGCCG GGCGGCTTAT GAGGCTTTCG ATGATTTCGACGGCAGCAGG 301 TTCCGCCGTT AAThis corresponds to the amino acid sequence <SEQ ID 2098; ORF 649.a>:

a649.pep 1 MLAILLSAIL GLVSTTAAAG TSEPAHRDTK HIRKANKQML HPECRKYLER 51RAAWYRSQGN VQELRENKKA RKAFRSLPYK EQKTQCRAAY EAFDDFDGSR 101 FRR*m649/a649 96.1% identity in 103 aa overlap        10        20        30        40        50        60 m649.pepMLAILLSAILGLVSTTAAAGTSEPAHRDTKHIRKANKQMLHPECRKYLERRAAWYRSQGN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a649MLAILLSAILGLVSTTAAAGTSEPAHRDTKHIRKANKQMLHPECRKYLERRAAWYRSQGN        10        20        30        40        50        60        70        80        90       100 m649.pepVQELRENKKARKAFRSLPYAEQKIQCRAAYEAFDDFDGGSFRRX||||||||||||||||||| ||| ||||||||||||||: |||| a649VQELRENKKARKAFRSLPYKEQKTQCRAAYEAFDDFDGSFRRX        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2099>:

g650.seq 1 ATGTCCAAAC TCAAAACCAT CGCCCTGACC GCATCAGGTC TGTCCGTTTG 51TCCGGGTTTC CTATATGCCC AAAACACCTC ATCACACCAA GTCGGTTTAG 101 CGATTATGCGGTTAAACTCT TCAATACTCG ACCTGCCACC GACAAAACAA 151 TATTTCCAAT CCGGCAGCCTGTGGGACGAG CTGCGCCAAG GCTTCCGGAT 201 GGGCGAAGTC AATCCCGAAC TGGTACGCCGCCACGAAAGC AAATTCATCG 251 CAAGCCGCAG CTATTTCGAC AGGGTCGTCA ACCGGAGCCGACCCTATATG 301 TACCATATCG CCAACGAAGT CAAAAAACGC AATATGCCCG CCGAAGCCGC351 CCTGCTTCCC TTCATCGAAA GCGCGTTCGT CACCAAAGCC AAATCACACG 401TCGGCGCATC GGGCCTGTGG CAGTTCATGC CCGCTACCGG CAGGCATTAC 451 GGCTTGGAAAAAACaccgGT TTACGacggc aggcacGacg TTtacgcaGc 501 taccgatgcc gcacTCAACTAtctGcAATA TCTCTAtggA CTGTTCGGCG 551 ACTGGCCGCT CGCCTTTGCC GCCTACAACTGGGGTGAAGG CAACGTCGGA 601 CGCGCCGTCA ACCGCGCCCG CGACCAAGGG CTCGAACCGACCTACGAAAA 651 CCTGCGTATG CCCAACGAAA CGCGCAACTA TGTCCCCAAG CTGCTCGCCG701 TGCGCAACAT TATTGCCACC CCCCAATCTT TCGGCATGAA TATCAGCGAC 751ATAGACAACA AACCCTATTT TCAGGCAGTC GAACCGGGCC GTCCGCTCGA 801 caacGAagcCATCGCCCGGC TTGCCGGCAT CACGCAAAGC GAGCTGCTCG 851 CCCTGAATCC TGCATTCAACGTCCCCGCgt tcatCCCCAA AAAcaaacgc 901 aaacTGCTGC TTCCTGTCGC GTCCGTCCAAACCTTccaaa gcaACTACCT 951 CAACGCCGCA CCCGACAGCC TGTTTTCATG GGAAGTCTATACGCCTGCCG 1001 CCAAAACCAG CCTGTCCGAC ATCTCGACGG CAACCGGCAT GAGCATTGCC1051 GACATCAAAC GCCTCAACAA CCTGAACGGC AACCTTGTCA ACGCAGGACG 1101CAGCATCCTT GTCGCCAAGA ACGGCAAGAC CCTTCATACG GCATCGGAat 1151 ccGTCGTTTCCATCGACATC GACAATACGC CcgacacCTa ccgttccaaT 1201 ATGCcggcag gcaCGGTGAACGTCAGCATt gccCgaatcc aacCCgccgc 1251 cgcaCAGACA gcggacatta ccgtcgcacctttgccgcaa gaaaccgtcc 1301 gtacgggaac ccgatcccct tgtccgcaTt accgaacccgccctTGCGAC 1351 AGCCGCAGCg CaacctCAAA ccgAAAAACA GACTGCCATG CcgtctGAThis corresponds to the amino acid sequence <SEQ ID 2100; ORF 650.ng>:

g650.pep 1 MSKLKTIALT ASGLSVCPGF LYAQNTSSHQ VGLAIMRLNS SILDLPPTKQ 51YFQSGSLWDE LRQGFRMGEV NPELVRRHES KFIASRSYFD RVVNRSRPYM 101 YHIANEVKKRNMPAEAALLP FIESAFVTKA KSHVGASGLW QFMPATGRHY 151 GLEKTPVYDG RHDVYAATDAALNYLQYLYG LFGDWPLAFA AYNWGEGNVG 201 RAVNRARDQG LEPTYENLRM PNETRNYVPKLLAVRNIIAT PQSFGMNISD 251 IDNKPYFQAV EPGRPLDNEA IARLAGITQS ELLALNPAFNVPAFIPKNKR 301 KLLLPVASVQ TFQSNYLNAA PDSLFSWEVY TPAAKTSLSD ISTATGMSIA351 DIKRLNNLNG NLVNAGRSIL VAKNGKTLHT ASESVVSIDI DNTPDTYRSN 401MPAGTVNVSI ARIQPAAAQT ADITVAPLPQ ETVRTGTRSP CPHYRTRPCD 451 SRSATSNRKTDCHAV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2101>:

m650.seq 1 ATGTCCAAAC TCAAAACCAT CGCTCTGACC GCATCAGGTC TGTCCGTTTG 51TCCGGGTTTC CTATACGCCC AAAACACCTC ATCACACCAA ATCGGTTTGG 101 CGATTATGCGCTTAAACTCT TCAATACTCG ACCTGCCCCC GACAAAACAA 151 TATTTCCAAT CCGGCAGCCTGTGGGGCGAG CTGCGCCAAG GCTTCCGGAT 201 GGGCGAAGTC AATCCCGAAC TGGTACGCCGCCACGAAAGC AAATTCATCG 251 CAAGCCACAG CTATTTCAAC AGGGTCATCA ACCGGAGTAGACCCTATATG 301 TACCATATCG CCAACGAAGT CAAAAAACGC AATATGCCCG CCGAAGCCGC351 CCTGCTTCCC TTCATCGAAA GCGCGTTCGT CACCAAAGCC AAATCACACG 401TCGGCGCATC AGGATTATGG CAGTTTATGC CCGCTACCGG CAGGCATTAC 451 GGCCTGGAAAAAACACCGGT TTACGACGGC AGGCACGACG TTTACGCCGC 501 CACCGATGCC GCACTCAACTATCTGCAATA CCTCTATGGA CTGTTCGGCG 551 ACTGGCCGCT TGCCTTTGCC GCCTACAACTGGGGTGAAGG CAACGTCGGA 601 CGCGCCATCA ACCGCGCCCG CGCCCAAGGG CTCGAACCGACCTACGAAAA 651 CCTGCGTATG CCCAACGAAA CGCGCAACTA TGTCCCCAAG CTGCTCGCCG701 TGCGCAACAT TATTGCCACT CCCCAATCTT TCGGCATGAA TATCAGCGAC 751ATAGACAACA AACCCTATTT TCAGGCAGTC GAACCGGATC GTCCGCTCGA 801 CAACGAAGCCATCGCCCGGC TTGCCGGCAT CACGCAAAGC GAGCTGCTCG 851 CCCTAAACCC CGCATTCAACGTCCCCGCGT TTATCCCCAA AAGCAAACGC 901 AAACTGCTGC TTCCTGTCGC GTCCGTACAAACCTTCCAAA GCAACTACCT 951 CAACGCCGCA CCCGACAGCC TGTTTTCATG GGAAGTCTATACGCCTGCCG 1001 CCAAAACCAG CCTGTCCGAC ATCTCGACGG CAACCGGCAT GAGCATTGCC1051 GACATCAAAC GCCTCAACAA CCTGAACGGC AACCTTGTCA ACGCAGGACG 1101CAGCATCCTT GTCGCCAAGA ACGGCAAAAC CCTTCAGACG GCATCGGAAT 1151 CCGTCGTTTCCATCGACATC GACAATACGC CCGACACCTA CCGTTCCAAT 1201 ATGCCGGCAG GCACGGTGAACGTCGGCATT GCCCGAATCC GACCCGCCGC 1251 CGCACAGACA GCGGACATTA CCGTCGCACCTTTGCCGCAG AAAACCGTCC 1301 GTACGG.AAC CCGATCCCCT TGTCCGTATT GCCGAACCTGCCCTTGCGAC 1351 AGCCGCAGCG CAACCTCAAA CCGAAAAACA GACCGCCATG CCGTCTGAThis corresponds to the amino acid sequence <SEQ ID 2102; ORF 650>:

m650.pep 1 MSKLKTIALT ASGLSVCPGF LYAQNTSSHQ IGLAIMRLNS SILDLPPTKQ 51YFQSGSLWGE LRQGFRMGEV NPELVRRHES KFIASHSYFN RVINRSRPYM 101 YHIANEVKKRNMPAEAALLP FIESAFVTKA KSHVGASGLW QFMPATGRHY 151 GLEKTPVYDG RHDVYAATDAALNYLQYLYG LFGDWPLAFA AYNWGEGNVG 201 RAINRARAQG LEPTYENLRM PNETRNYVPKLLAVRNIIAT PQSFGMNISD 251 IDNKPYFQAV EPDRPLDNEA IARLAGITQS ELLALNPAFNVPAFIPKSKR 301 KLLLPVASVQ TFQSNYLNAA PDSLFSWEVY TPAAKTSLSD ISTATGMSIA351 DIKRLNNLNG NLVNAGRSIL VAKNGKTLQT ASESVVSIDI DNTPDTYRSN 401MPAGTVNVGI ARIRPAAAQT ADITVAPLPQ KTVRTXTRSP CPYCRTCPCD 451 SRSATSNRKTDRHAV* m650/g650 96.1% identity in 465 aa overlap        10        20        30        40        50        60 m650.pepMSKLKTIALTASGLSVCPGFLYAQNTSSHQIGLAIMRLNSSILDLPPTKQYFQSGSLWGE||||||||||||||||||||||||||||||:||||||||||||||||||||||||||| | g650MSKLKTIALTASGLSVCPGFLYAQNTSSHQVGLAIMRLNSSILDLPPTKQYFQSGSLWDE        10        20        30        40        50        60        70        80        90       100       110       120 m650.pepLRQGFRMGEVNPELVRRHESKFIASHSYFNRVINRSRPYMYHIANEVKKRNMPAEAALLP|||||||||||||||||||||||||:|||:||:||||||||||||||||||||||||||| g650LRQGFRMGEVNPELVRRHESKFIASRSYFDRVVNRSRPYMYHIANEVKKRNMPAEAALLP        70        80        90       100       110       120       130       140       150       160       170       180 m650.pepFIESAFVTKAKSHVGASGLWQFMPATGRHYGLEKTPVYDGRHDVYAATDAALNYLQYLYG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g650FIESAFVTKAKSHVGASGLWQFMPATGRHYGLEKTPVYDGRHDVYAATDAALNYLQYLYG       130       140       150       160       170       180       190       200       210       220       230       240 m650.pepLFGDWPLAFAAYNWGEGNVGRAINRARAQGLEPTYENLRMPNETRNYVPKLLAVRNIIAT||||||||||||||||||||||:|||| |||||||||||||||||||||||||||||||| g650LFGDWPLAFAAYNWGEGNVGRAVNRARDQGLEPTYENLRMPNETRNYVPKLLAVRNIIAT       190       200       210       220       230       240       250       260       270       280       290       300 m650.pepPQSFGMNISDIDNKPYFQAVEPDRPLDNEAIARLAGITQSELLALNPAFNVPAFIPKSKR|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||:|| g650PQSFGMNISDIDNKPYFQAVEPGRPLDNEAIARLAGITQSELLALNPAFNVPAFIPKNKR       250       260       270       280       290       300       310       320       330       340       350       360 m650.pepKLLLPVASVQTFQSNYLNAAPDSLFSWEVYTPAAKTSLSDISTATGMSIADIKRLNNLNG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g650KLLLPVASVQTFQSNYLNAAPDSLFSWEVYTPAAKTSLSDISTATGMSIADIKRLNNLNG       310       320       330       340       350       360       370       380       390       400       410       420 m650.pepNLVNAGRSILVAKNGKTLQTASESVVSIDIDNTPDTYRSNMPAGTVNVGIARIRPAAAQT||||||||||||||||||:|||||||||||||||||||||||||||||:||||:|||||| g650NLVNAGRSILVAKNGKTLHTASESVVSIDIDNTPDTYRSNMPAGTVNVSIARIQPAAAQT       370       380       390       400       410       420       430       440       450       460 m650.pepADITVAPLPQKTVRTXTRSPCPYCRTCPCDSRSATSNRKTDRHAVX ||||||||||:|||| ||||||:|| |||||||||||||| |||| g650ADITVAPLPQETVRTGTRSPCPHYRTRPCDSRSATSNRKTDCHAVX       430       440       450       460The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2103>:

a650.seq 1 ATGTCCAAAC TCAAAACCAT CGCCCTGACC GCGTCAGGTC TGTCCGTTTG 51TCCGGGTTTC CTATACGCCC AAAACACCTC ATCACACCAA ATCGGTTTGG 101 CGATTATGCGCTTAAACTCT TCAATACTCG ACCTGCCACC GACAAAACAA 151 TATTTCCAAT CCGGCAGCCTGTGGAGCGAG CTGCGCCAAG GCTTCCGGAT 201 GGGCGAAGTC AATCCCGAAC TGGTACGCCGCCACGAAAGC AAATTCATCG 251 CAAGCCACAG CTATTTCAAC AGGGTCATCA ACCGGAGTAGACCCTATATG 301 TACCATATCG CCAACGAAGT CAAAAAACGC AATATGCCCG CCGAAGCCGC351 CCTGCTTCCC TTCATCGAAA GCGCGTTCGT CACCAAAGCC AAATCACACG 401TCGGCGCATC GGGCCTGTGG CAGTTCATGC CCGCTACCGG CAGGCATTAC 451 GGCCTGGAAAAAACACCGGT TTACGACGGC AGGCACGACA TTTACGCCGC 501 CACCGATGCC GCACTCAACTATCTGCAATA CCTCTATGGA CTGTTCGGCG 551 ACTGGCCGCT CGCCTTTGCC GCCTACAACTGGGGTGAAGG CAACGTCGGA 601 CGCGCCATCA ACCGCGCCCG CGCCCAAGGG CTCGAACCGACCTACGAAAA 651 CCTGCGTATG CCCAACGAAA CGCGCAACTA TGTTCCCAAG CTGCTCGCCG701 TGCGCAACAT CATTGCCGCC CCCCAATCTT TCGGCATGAA TATCAGCGAC 751ATAGACAACA AACCGTATTT TCAGGCAGTC GAACCGGACC GTCCGCTCGA 801 CAACGAAGCCATCGCCCGGC TTGCCGGCAT CACGCAAAGC GAGCTGCTCG 851 CCCTAAACCC CGCATTCAACGTCCCCGCGT TCATCCCCAA AAGCAAACGC 901 AAACTGCTGC TTCCTGTCGC GTCCGTACAAACCTTCCAAA GCAACTACCT 951 CAACGCCGCA CCCGACAGCC TGTTTTCATG GGAAGTCTATACGCCTGCCG 1001 CCAAAACCAG CTTGTCCGAC ATCTCGACGG CAACCGGCAT GAGCATTGCC1051 GACATCAAAC GCCTCAACAA CCTGAACGGC AACCTTGTCA ACGCAGGACG 1101CAGCATCCTT GTCGCCAAGA ACGGCAAAAC CCTTCAGACG GCATCGGAAT 1151 CCGTCGTTTCCATCGACATC GACAATACGC CCAACACCTA CCGTTCCAAT 1201 ATGCCGGCAG GCACGGTGAACGTCGGCATT GCCCGAATCC GACCCGCCGC 1251 CGCACAGACA GCGGACATTA CCGTCGCACCTTTGCCGCAG AAAACCGTCC 1301 GTACGG.AAC CCGATCCCCT TGTCCGTATT GCCGAACCTGCCCTTGCGAC 1351 AGCCGCAGCG CAACCTCAAA CCGAAAAACA GACCGCCATG CCGTCTGAThis corresponds to the amino acid sequence <SEQ ID 2104; ORF 650.a>:

a650.pep 1 MSKLKTIALT ASGLSVCPGF LYAQNTSSHQ IGLAIMRLNS SILDLPPTKQ 51YFQSGSLWSE LRQGFRMGEV NPELVRRHES KFIASHSYFN RVINRSRPYM 101 YHIANEVKKRNMPAEAALLP FIESAFVTKA KSHVGASGLW QFMPATGRHY 151 GLEKTPVYDG RHDIYAATDAALNYLQYLYG LFGDWPLAFA AYNWGEGNVG 201 RAINRARAQG LEPTYENLRM PNETRNYVPKLLAVRNIIAA PQSFGMNISD 251 IDNKPYFQAV EPDRPLDNEA IARLAGITQS ELLALNPAFNVPAFIPKSKR 301 KLLLPVASVQ TFQSNYLNAA PDSLFSWEVY TPAAKTSLSD ISTATGMSIA351 DIKRLNNLNG NLVNAGRSIL VAKNGKTLQT ASESVVSIDI DNTPNTYRSN 401MPAGTVNVGI ARIRPAAAQT ADITVAPLPQ KTVRTXTRSP CPYCRTCPCD 451 SRSATSNRKTDRHAV* m650/a650 99.1% identity in 465 aa overlap        10        20        30        40        50        60 m650.pepMSKLKTIALTASGLSVCPGFLYAQNTSSHQIGLAIMRLNSSILDLPPTKQYFQSGSLWGE||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:| a650MSKLKTIALTASGLSVCPGFLYAQNTSSHQIGLAIMRLNSSILDLPPTKQYFQSGSLWSE        10        20        30        40        50        60        70        80        90       100       110       120 m650.pepLRQGFRMGEVNPELVRRHESKFIASHSYFNRVINRSRPYMYHIANEVKKRNMPAEAALLP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a650LRQGFRMGEVNPELVRRHESKFIASHSYFNRVINRSRPYMYHIANEVKKRNMPAEAALLP        70        80        90       100       110       120       130       140       150       160       170       180 m650.pepFIESAFVTKAKSHVGASGLWQFMPATGRHYGLEKTPVYDGRHDVYAATDAALNYLQYLYG|||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||| a650FIESAFVTKAKSHVGASGLWQFMPATGRHYGLEKTPVYDGRHDIYAATDAALNYLQYLYG       130       140       150       160       170       180       190       200       210       220       230       240 m650.pepLFGDWPLAFAAYNWGEGNVGRAINRARAQGLEPTYENLRMPNETRNYVPKLLAVRNIIAT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: a650LFGDWPLAFAAYNWGEGNVGRAINRARAQGLEPTYENLRMPNETRNYVPKLLAVRNIIAA       190       200       210       220       230       240       250       260       270       280       290       300 m650.pepPQSFGMNISDIDNKPYFQAVEPDRPLDNEAIARLAGITQSELLALNPAFNVPAFIPKSKR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a650PQSFGMNISDIDNKPYFQAVEPDRPLDNEATARLAGITQSELLALNPAFNVPAFIPKSKR       250       260       270       280       290       300       310       320       330       340       350       360 m650.pepKLLLPVASVQTFQSNYLNAAPDSLFSWEVYTPAAKTSLSDISTATGMSIADIKRLNNLNG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a650KLLLPVASVQTFQSNYLNAAPDSLFSWEVYTPAAKTSLSDISTATGMSIADIKRLNNLNG       310       320       330       340       350       360       370       380       390       400       410       420 m650.pepNLVNAGRSILVAKNGKTLQTASESVVSIDIDNTPDTYRSNMPAGTVNVGIARIRPAAAQT|||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| a650NLVNAGRSILVAKNGKTLQTASESVVSIDIDNTPNTYRSNMPAGTVNVGIARIRPAAAQT       370       380       390       400       410       420       430       440       450       460 m650.pepADITVAPLPQKTVRTXTRSPCPYCRTCPCDSRSATSNRKTDRHAVX|||||||||||||||||||||||||||||||||||||||||||||| a650ADITVAPLPQKTVRTXTRSPCPYCRTCPCDSRSATSNRKTDRHAVX       430       440       450       460The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2105>:

g652.seq 1 ATGATCGAAT TGGACGGTAC TGAAAACAAA GGCAATTTGG GTGCGAATGC 51GACTTTGGCG GTCTCTATGG CGGTTGCACG CGCCGCTGCC GAAGACTCAG 101 GCCTGCCGCTTTACCGCTAC TTGGGGGGCG CAGGTCCGAT GTCCCTGCCC 151 GTACCGATGA TGAACGTCATCAACGGCGGC GAACACGCCA ACAACAGCCT 201 GAACATCCAA GAGTTTATGA TTATGCCCGTCGGCGCAAAA TCTTTCCGCG 251 AAGCGTTGCG CTGCGGTGCG GAAATTTTCC ACGCCTTGAAAAAACTGTGC 301 GACAGTAAAG GCTTCCCGAC CACAGTCGGC GACGAAGGCG GTTTCGCCCC351 CAACCTGAAC AGCCACAAAG AAGCCCTGCA ACTGATGGTC GAAGCGGCCG 401AAGCCGCCGG CTACAAGGCG GGCGAAGACG TATTATTCGC ATTGGACTGC 451 GCGTCCAGCGAGTTCTACAA AGACGGCAAA TACCACTTGG AAGCCGAAGG 501 CCGCTCCTAC ACCAACGCGGAATTTGCCGA ATACTTGGAA GGCTTGGTTA 551 ACGAATTCCC GATTATTTCC ATTGAAGACGGGATGGACGA AAACGACTGG 601 GAAGGCTGGA AACTGCTGAC CGAAAAATTG GGCAAAAAAGTTCAATTGGT 651 CGGCGACGAC TTGTTCGTAA CCAATCCGAA AATTCTTGCC GAAGGCATCG701 AAAAAGGCGT AGCAAACGCA TTGCTGGTCA AAGTCAACCA AATCGGTACT 751TTAAGCGAAA CCCTGAAAGc cgtcgatctg gCAAAATGCA accgctacGc 801 cagCGTGATGAGCCAccgct ccggCGAAAC CGAAGACAGT Accattgccg 851 ACTTGGCAGT CGCCACCAACTGTATGCAGA TTAAAAccgG TTCTTTGAGc 901 cgTTCCGACC GCATGGCGAA ATACAACCAactGCTGCGTA TCGAGGAAGA 951 ATTGGCGGAA GCcgcctACT ACCCCGGCAA AGCCGCATTCTACCAACTGG 1001 GCAAATAAThis corresponds to the amino acid sequence <SEQ ID 2106; ORF 652.ng>:

g652.pep 1 MIELDGTENK GNLGANATLA VSMAVARAAA EDSGLPLYRY LGGAGPMSLP 51VPMMNVINGG EHANNSLNIQ EFMIMPVGAK SFREALRCGA EIFHALKKLC 101 DSKGFPTTVGDEGGFAPNLN SHKEALQLMV EAAEAAGYKA GEDVLFALDC 151 ASSEFYKDGK YHLEAEGRSYTNAEFAEYLE GLVNEFPIIS IEDGMDENDW 201 EGWKLLTEKL GKKVQLVGDD LFVTNPKILAEGIEKGVANA LLVKVNQIGT 251 LSETLKAVDL AKCNRYASVM SHRSGETEDS TIADLAVATNCMQIKTGSLS 301 RSDRMAKYNQ LLRIEEELAE AAYYPGKAAF YQLGK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2107>:

m652.seq 1 ATGATCGAAT TGGACGGTAC TGAAAACAAA GGCAATTTGG GTGCGAATGC 51GACTTTGGCG GTTTCTATGG CGGTTGCACG CGCCGCTGCC GAAGACTCAG 101 GCCTGCCGCTTTACCGCTAC TTGGGCGGCG CAGGCCCGAT GTCCCTGCCC 151 GTACCGATGA TGAACGTCATCAACGGCGGC GAACACGCCA ACAACAGCCT 201 GAACATCCAA GAGTTTATGA TTATGCCCGTCGGCGCAAAA TCTTTCCGCG 251 AAGCGTTGCG CTGCGGTGCG GAAATTTTCC ACGCCTTGAAAAAACTGTGC 301 GACAGCAAAG GCTTCCCGAC CACAGTCGGC GACGAAGGCG GTTTCGCCCC351 CAACCTGAAC AGCCACAAAG AAGCCCTGCA ACTGATGGTC GAGGCGACCG 401AAGCCGCCGG CTACAAAGCG GGCGAAGACG TATTATTCGC ATTGGACTGC 451 GCCTCCAGCGAGTTCTACAA AGACGGCAAA TACCACTTGG AAGCCGAAGG 501 CCGCTCCTAC ACCAACGCGGAATTTGCCGA ATATCTGGAA GGCCTGGTCA 551 ACGAGTTCCC CATCATCTCC ATCGAAGACGGCATGGATGA AAACGACTGG 601 GAAGGCTGGA AACTGCTGAC CGAAAAACTG GGCGGTAGAGTTCAATTGGT 651 TGGCGACGAC TTGTTCGTAA CCAATCCAAA AATCTTGGCC GAAGGCATCG701 AAAAAGGCGT AGCAAACGCA TTGCTGGTCA AAGTCAATCA AATCGGTACT 751TTGAGCGAGA CCCTGAAAGC CGTCGACTTA GCCAAACGCA ACCGCTACGC 801 CAGCGTAATGAGCCACCGCT CCGGCGAAAC CGAAGACAGC ACCATTGCCG 851 ACTTGGCAGT CGCCACCAACTGTATGCAGA TCAAAACCGG TTCTTTGAGC 901 CGTTCCGACC GCATGGCGAA ATACAACCAACTGCTGCGTA TCGAGGAAGA 951 ATTGGCGGAA GCCGCCGACT ACCCCAGCAA AGCCGCATTCTACCAACTGG 1001 GCAAATAAThis corresponds to the amino acid sequence <SEQ ID 2108; ORF 652>:

m652.pep 1 MIELDGTENK GNLGANATLA VSMAVARAAA EDSGLPLYRY LGGAGPMSLP 51VPMMNVINGG EHANNSLNIQ EFMIMPVGAK SFREALRCGA EIFHALKKLC 101 DSKGFPTTVGDEGGFAPNLN SHKEALQLMV EATEAAGYKA GEDVLFALDC 151 ASSEFYKDGK YHLEAEGRSYTNAEFAEYLE GLVNEFPIIS IEDGMDENDW 201 EGWKLLTEKL GGRVQLVGDD LFVTNPKILAEGIEKGVANA LLVKVNQIGT 251 LSETLKAVDL AKRNRYASVM SHRSGETEDS TIADLAVATNCMQIKTGSLS 301 RSDRMAKYNQ LLRIEEELAE AADYPSKAAF YQLGK* m652/g652 98.2%identity in 335 aa overlap        10        20        30        40        50        60 m652.pepMIELDGTENKGNLGANATLAVSMAVARAAAEDSGLPLYRYLGGAGPMSLPVPMMNVINGG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g652MIELDGTENKGNLGANATLAVSMAVARAAAEDSGLPLYRYLGGAGPMSLPVPMMNVINGG        10        20        30        40        50        60        70        80        90       100       110       120 m652.pepEHANNSLNIQEFMIMPVGAKSFREALRCGAEIFHALKKLCDSKGFPTTVGDEGGFAPNLN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g652EHANNSLNIQEFMIMPVGAKSFREALRCGAEIFHALKKLCDSKGFPTTVGDEGGFAPNLN        70        80        90       100       110       120       130       140       150       160       170       180 m652.pepSHKEALQLMVEATEAAGYKAGEDVLFALDCASSEFYKDGKYHLEAEGRSYTNAEFAEYLE||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| g652SHKEALQLMVEAAEAAGYKAGEDVLFALDCASSEFYKDGKYHLEAEGRSYTNAEFAEYLE       130       140       150       160       170       180       190       200       210       220       230       240 m652.pepGLVNEFPIISIEDGMDENDWEGWKLLTEKLGGRVQLVGDDLFVTNPKILAEGIEKGVANA||||||||||||||||||||||||||||||| :||||||||||||||||||||||||||| g652GLVNEFPIISIEDGMDENDWEGWKLLTEKLGKKVQLVGDDLFVTNPKILAEGIEKGVANA       190       200       210       220       230       240       250       260       270       280       290       300 m652.pepLLVKVNQIGTLSETLKAVDLAKRNRYASVMSHRSGETEDSTIADLAVATNCMQIKTGSLS|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| g652LLVKVNQIGTLSETLKAVDLAKCNRYASVMSHRSGETEDSTIADLAVATNCMQIKTGSLS       250       260       270       280       290       300       310       320       330 m652.pepRSDRMAKYNQLLRIEEELAEAADYPSKAAFYQLGKX|||||||||||||||||||||| ||:|||||||||| g652RSDRMAKYNQLLRIEEELAEAAYYPGKAAFYQLGKX        310       320       330The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2109>:

a652.seq 1 ATGATCGAAT TGGACGGTAC TGAAAACAAA GGCAATTTGG GTGCGAATGC 51GACTTTGGCG GTTTCTATGG CGGTTGCACG CGCCGCTGCC GAAGACTCAG 101 GCCTGCCGCTTTACCGCTAC TTGGGCGGCG CAGGCCCGAT GTCCCTGCCC 151 GTACCGATGA TGAACGTCATCAACGGCGGC GAACACGCCA ACAACAGCCT 201 GAACATCCAA GAGTTTATGA TTATGCCCGTCGGCGCAAAA TCTTTCCGCG 251 AAGCGTTGCG CTGCGGTGCG GAAATTTTCC ACGCCTTGAAAAAACTGTGC 301 GACAGCAAAG GCTTCCCGAC CACAGTCGGC GACGAAGGCG GTTTCGCCCC351 CAACCTGAAC AGCCACAAAG AAGCCCTGCA ACTGATGGTC GAGGCGACCG 401AAGCCGCCGG CTACAAAGCG GGCGAAGACG TATTATTCGC ATTGGACTGC 451 GCGTCCAGCGAGTTCTACAA AGACGGCAAA TACCACTTGG AAGCCGAAGG 501 CCGCTCCTAC ACCAACGCGGAATTTGCCGA ATATCTGGAA GGCCTGGTCA 551 ACGAGTTCCC CATCATCTCC ATCGAAGACGGGATGGATGA AAACGACTGG 601 GAAGGCTGGA AACTGCTGAC CGAAAAACTG GGCGGCAAAGTCCAACTCGT 651 TGGCGACGAC CTCTTCGTTA CCAACCCGAA AATCCTTGCC GAAGGCATTG701 AAAAAGGCGT GGCAAACGCA CTATTGGTCA AAGTCAACCA AATCGGTACT 751TTGAGTGAAA CCCTGAAAGC CGTCGACTTA GCCAAACGCA ACCGCTACGC 801 CAGCGTAATGAGCCACCGCT CCGGCGAAAC CGAAGACAGC ACCATTGCCG 851 ACTTGGCAGT CGCCACCAACTGTATGCAGA TCAAAACCGG TTCTTTGAGC 901 CGTTCCGACC GCATGGCGAA ATACAACCAACTGCTGCGTA TCGAGGAAGA 951 ATTGGCGGAA GCCGCCGACT ACCCCAGCAA AGCCGCATTCTACCAACTGG 1001 GCAAATAAThis corresponds to the amino acid sequence <SEQ ID 2110; ORF 652.a>:

a652.pep 1 MIELDGTENK GNLGANATLA VSMAVARAAA EDSGLPLYRY LGGAGPMSLP 51VPMMNVINGG EHANNSLNIQ EFMIMPVGAK SFREALRCGA EIFHALKKLC 101 DSKGFPTTVGDEGGFAPNLN SHKEALQLMV EATEAAGYKA GEDVLFALDC 151 ASSEFYKDGK YHLEAEGRSYTNAEFAEYLE GLVNEFPIIS IEDGMDENDW 201 EGWKLLTEKL GGKVQLVGDD LFVTNPKILAEGIEKGVANA LLVKVNQIGT 251 LSETLKAVDL AKRNRYASVM SHRSGETEDS TIADLAVATNCMQIKTGSLS 301 RSDRMAKYNQ LLRIEEELAE AADYPSKAAF YQLGK* m652/a652 99.7%identity in 335 aa overlap        10        20        30        40        50        60 m652.pepMIELDGTENKGNLGANATLAVSMAVARAAAEDSGLPLYRYLGGAGPMSLPVPMMNVINGG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a652MIELDGTENKGNLGANATLAVSMAVARAAAEDSGLPLYRYLGGAGPMSLPVPMMNVINGG        10        20        30        40        50        60        70        80        90       100       110       120 m652.pepEHANNSLNIQEFMIMPVGAKSFREALRCGAEIFHALKKLCDSKGFPTTVGDEGGFAPNLN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a652EHANNSLNIQEFMIMPVGAKSFREALRCGAEIFHALKKLCDSKGFPTTVGDEGGFAPNLN        70        80        90       100       110       120       130       140       150       160       170       180 m652.pepSHKEALQLMVEATEAAGYKAGEDVLFALDCASSEFYKDGKYHLEAEGRSYTNAEFAEYLE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a652SHKEALQLMVEATEAAGYKAGEDVLFALDCASSEFYKDGKYHLEAEGRSYTNAEFAEYLE       130       140       150       160       170       180       190       200       210       220       230       240 m652.pepGLVNEFPIISIEDGMDENDWEGWKLLTEKLGGRVQLVGDDLFVTNPKILAEGIEKGVANA||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||| a652GLVNEFPIISIEDGMDENDWEGWKLLTEKLGGKVQLVGDDLFVTNPKILAEGIEKGVANA       190       200       210       220       230       240       250       260       270       280       290       300 m652.pepLLVKVNQIGTLSETLKAVDLAKRNRYASVMSHRSGETEDSTIADLAVATNCMQIKTGSLS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a652LLVKVNQIGTLSETLKAVDLAKRNRYASVMSHRSGETEDSTIADLAVATNCMQIKTGSLS       250       260       270       280       290       300       310       320       330 m652.pepRSDRMAKYNQLLRIEEELAEAADYPSKAAFYQLGKX|||||||||||||||||||||||||||||||||||| a652 RSDRMAKYNQ LLRIEEELAEAADYPSKAAFYQLGKX        310       320       330The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2111>:

g652-1.seq 1 ATGAGCGCAA TCGTTGATAT TTTCGCCCGC GAAATTTTGG ACTCACGCGG 51CAACCCCACA GTCGAGTGTG ATGTATTGCT CGAATCCGGC GTAATGGGAC 101 GTGCGGCCGTACCGAGCGGC GCATCCACCG GTCAGAAAGA AGCTTTGGAA 151 CTTCGCGACG GCGACAAATCCCGCTATTCC GGCAAAGGCG TATTGAAGGC 201 CGTCGAACAC GTCAACAACC AAATCGCCCAAGCCCTCATC GGTATCGATG 251 CCAACGAGCA ATCTTATATC GACCAAATCA TGATCGAATTGGACGGTACT 301 GAAAACAAAG GCAATTTGGG TGCGAATGCG ACTTTGGCGG TCTCTATGGC351 GGTTGCACGC GCCGCTGCCG AAGACTCAGG CCTGCCGCTT TACCGCTACT 401TGGGGGGCGC AGGTCCGATG TCCCTGCCCG TACCGATGAT GAACGTCATC 451 AACGGCGGCGAACACGCCAA CAACAGCCTG AACATCCAAG AGTTTATGAT 501 TATGCCCGTC GGCGCAAAATCTTTCCGCGA AGCGTTGCGC TGCGGTGCGG 551 AAATTTTCCA CGCCTTGAAA AAACTGTGCGACAGTAAAGG CTTCCCGACC 601 ACAGTCGGCG ACGAAGGCGG TTTCGCCCCC AACCTGAACAGCCACAAAGA 651 AGCCCTGCAA CTGATGGTCG AAGCGGCCGA AGCCGCCGGC TACAAGGCGG701 GCGAAGACGT ATTATTCGCA TTGGACTGCG CGTCCAGCGA GTTCTACAAA 751GACGGCAAAT ACCACTTGGA AGCCGAAGGC CGCTCCTACA CCAACGCGGA 801 ATTTGCCGAATACTTGGAAG GCTTGGTTAA CGAATTCCCG ATTATTTCCA 851 TTGAAGACGG GATGGACGAAAACGACTGGG AAGGCTGGAA ACTGCTGACC 901 GAAAAATTGG GCAAAAAAGT TCAATTGGTCGGCGACGACT TGTTCGTAAC 951 CAATCCGAAA ATTCTTGCCG AAGGCATCGA AAAAGGCGTAGCAAACGCAT 1001 TGCTGGTCAA AGTCAACCAA ATCGGTACTT TAAGCGAAAC CCTGAAAGCC1051 GTCGATCTGG CAAAATGCAA CCGCTACGCC AGCGTGATGA GCCACCGCTC 1101CGGCGAAACC GAAGACAGTA CCATTGCCGA CTTGGCAGTC GCCACCAACT 1151 GTATGCAGATTAAAACCGGT TCTTTGAGCC GTTCCGACCG CATGGCGAAA 1201 TACAACCAAC TGCTGCGTATCGAGGAAGAA TTGGCGGAAG CCGCCTACTA 1251 CCCCGGCAAA GCCGCATTCT ACCAACTGGGCAAATAAThis corresponds to the amino acid sequence <SEQ ID 2112; ORF 652-1.ng>:

g652-1.pep 1 MSAIVDIFAR EILDSRGNPT VECDVLLESG VMGRAAVPSG ASTGQKEALE 51LRDGDKSRYS GKGVLKAVEH VNNQIAQALI GIDANEQSYI DQIMIELDGT 101 ENKGNLGANATLAVSMAVAR AAAEDSGLPL YRYLGGAGPM SLPVPMMNVI 151 NGGEHANNSL NIQEFMIMPVGAKSFREALR CGAEIFHALK KLCDSKGFPT 201 TVGDEGGFAP NLNSHKEALQ LMVEAAEAAGYKAGEDVLFA LDCASSEFYK 251 DGKYHLEAEG RSYTNAEFAE YLEGLVNEFP IISIEDGMDENDWEGWKLLT 301 EKLGKKVQLV GDDLFVTNPK ILAEGIEKGV ANALLVKVNQ IGTLSETLKA351 VDLAKCNRYA SVMSHRSGET EDSTIADLAV ATNCMQIKTG SLSRSDRMAK 401YNQLLRIEEE LAEAAYYPGK AAFYQLGK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2113>:

m652-1.seq 1 ATGAGCGCAA TCGTTGATAT TTTCGCCCGC GAAATTTTGG ACTCACGCGG 51CAACCCCACA GTCGAGTGTG ATGTATTGCT CGAATCCGGC GTAATGGGAC 101 GCGCAGCCGTACCGAGCGGC GCGTCCACCG GTCAAAAAGA GGCTTTGGAA 151 CTTCGCGACG GCGACAAATCCCGTTATTCG GGCAAGGGCG TATTGAAGGC 201 GGTCGAACAC GTCAACAACC AAATCGCCCAAGCCCTCATT GGTATCGATG 251 CCAACGAGCA ATCTTATATC GACCAAATCA TGATCGAATTGGACGGTACT 301 GAAAACAAAG GCAATTTGGG TGCGAATGCG ACTTTGGCGG TTTCTATGGC351 GGTTGCACGC GCCGCTGCCG AAGACTCAGG CCTGCCGCTT TACCGCTACT 401TGGGCGGCGC AGGCCCGATG TCCCTGCCCG TACCGATGAT GAACGTCATC 451 AACGGCGGCGAACACGCCAA CAACAGCCTG AACATCCAAG AGTTTATGAT 501 TATGCCCGTC GGCGCAAAATCTTTCCGCGA AGCGTTGCGC TGCGGTGCGG 551 AAATTTTCCA CGCCTTGAAA AAACTGTGCGACAGCAAAGG CTTCCCGACC 601 ACAGTCGGCG ACGAAGGCGG TTTCGCCCCC AACCTGAACAGCCACAAAGA 651 AGCCCTGCAA CTGATGGTCG AGGCGACCGA AGCCGCCGGC TACAAAGCGG701 GCGAAGACGT ATTATTCGCA TTGGACTGCG CCTCCAGCGA GTTCTACAAA 751GACGGCAAAT ACCACTTGGA AGCCGAAGGC CGCTCCTACA CCAACGCGGA 801 ATTTGCCGAATATCTGGAAG GCCTGGTCAA CGAGTTCCCC ATCATCTCCA 851 TCGAAGACGG CATGGATGAAAACGACTGGG AAGGCTGGAA ACTGCTGACC 901 GAAAAACTGG GCGGTAGAGT TCAATTGGTTGGCGACGACT TGTTCGTAAC 951 CAATCCAAAA ATCTTGGCCG AAGGCATCGA AAAAGGCGTAGCAAACGCAT 1001 TGCTGGTCAA AGTCAATCAA ATCGGTACTT TGAGCGAGAC CCTGAAAGCC1051 GTCGACTTAG CCAAACGCAA CCGCTACGCC AGCGTAATGA GCCACCGCTC 1101CGGCGAAACC GAAGACAGCA CCATTGCCGA CTTGGCAGTC GCCACCAACT 1151 GTATGCAGATCAAAACCGGT TCTTTGAGCC GTTCCGACCG CATGGCGAAA 1201 TACAACCAAC TGCTGCGTATCGAGGAAGAA TTGGCGGAAG CCGCCGACTA 1251 CCCCAGCAAA GCCGCATTCT ACCAACTGGGCAAATAAThis corresponds to the amino acid sequence <SEQ ID 2114; ORF 652-1>:

m652-1.pep 1 MSAIVDIFAR EILDSRGNPT VECDVLLESG VMGRAAVPSG ASTGQKEALE 51LRDGDKSRYS GKGVLKAVEH VNNQIAQALI GIDANEQSYI DQIMIELDGT 101 ENKGNLGANATLAVSMAVAR AAAEDSGLPL YRYLGGAGPM SLPVPMMNVI 151 NGGEHANNSL NIQEFMIMPVGAKSFREALR CGAEIFHALK KLCDSKGFPT 201 TVGDEGGFAP NLNSHKEALQ LMVEATEAAGYKAGEDVLFA LDCASSEFYK 251 DGKYHLEAEG RSYTNAEFAE YLEGLVNEFP IISIEDGMDENDWEGWKLLT 301 EKLGGRVQLV GDDLFVTNPK ILAEGIEKGV ANALLVKVNQ IGTLSETLKA351 VDLAKRNRYA SVMSHRSGET EDSTIADLAV ATNCMQIKTG SLSRSDRMAK 401YNQLLRIEEE LAEAADYPSK AAFYQLGK* m652-1/g652-1 98.6% identity in 428 aaoverlap         10        20        30        40        50        60m652-1 MSAIVDIFAREILDSRGNPTVECDVLLESGVMGRAAVPSGASTGQKEALELRDGDKSRYS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g652-1MSAIVDIFAREILDSRGNPTVECDVLLESGVMGRAAVPSGASTGQKEALELRDGDKSRYS        10        20        30        40        50        60        70        80        90       100       110       120 m652-1GKGVLKAVEHVNNQIAQALIGIDANEQSYIDQIMIELDGTENKGNLGANATLAVSMAVAR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g652-1GKGVLKAVEHVNNQIAQALIGIDANEQSYIDQIMIELDGTENKGNLGANATLAVSMAVAR        70        80        90       100       110       120       130       140       150       160       170       180 m652-1AAAEDSGLPLYRYLGGAGPMSLPVPMMNVINGGEHANNSLNIQEFMIMPVGAKSFREALR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g652-1AAAEDSGLPLYRYLGGAGPMSLPVPMMNVINGGEHANNSLNIQEFMIMPVGAKSFREALR       130       140       150       160       170       180       190       200       210       220       230       240 m652-1CGAEIFHALKKLCDSKGFPTTVGDEGGFAPNLNSHKEALQLMVEATEAAGYKAGEDVLFA|||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||| g652-1CGAEIFHALKKLCDSKGFPTTVGDEGGFAPNLNSHKEALQLMVEAAEAAGYKAGEDVLFA       190       200       210       220       230       240       250       260       270       280       290       300 m652-1LDCASSEFYKDGKYHLEAEGRSYTNAEFAEYLEGLVNEFPIISIEDGMDENDWEGWKLLT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g652-1LDCASSEFYKDGKYHLEAEGRSYTNAEFAEYLEGLVNEFPIISIEDGMDENDWEGWKLLT       250       260       270       280       290       300       310       320       330       340       350       360 m652-1EKLGGRVQLVGDDLFVTNPKILAEGIEKGVANALLVKVNQIGTLSETLKAVDLAKRNRYA|||| :||||||||||||||||||||||||||||||||||||||||||||||||| |||| g652-1EKLGKKVQLVGDDLFVTNPKILAEGIEKGVANALLVKVNQIGTLSETLKAVDLAKCNRYA       310       320       330       340       350       360       370       380       390       400       410       420 m652-1SVMSHRSGETEDSTIADLAVATNCMQIKTGSLSRSDRMAKYNQLLRIEEELAEAADYPSK||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||:| g652-1SVMSHRSGETEDSTIADLAVATNCMQIKTGSLSRSDRMAKYNQLLRIEEELAEAAYYPGK       370       380       390       400       410       420       429m652-1 AAFYQLGKX ||||||||| g652-1 AAFYQLGKXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2115>:

a652-1.seq 1 ATGAGCGCAA TCGTTGATAT TTTCGCCCGC GAAATTTTGG ACTCACGCGG 51CAACCCCACA GTCGAGTGTG ATGTATTGCT CGAATCCGGC GTAATGGGAC 101 GCGCAGCCGTACCGAGCGGC GCGTCCACCG GTCAAAAAGA GGCTTTGGAA 151 CTTCGCGACG GCGACAAATCCCGTTATTCG GGCAAGGGCG TATTGAAGGC 201 GGTCGAACAC GTCAACAACC AAATCGCCCAAGCCCTCATT GGTATCGATG 251 CCAACGAGCA ATCTTATATC GACCAAATCA TGATCGAATTGGACGGTACT 301 GAAAACAAAG GCAATTTGGG TGCGAATGCG ACTTTGGCGG TTTCTATGGC351 GGTTGCACGC GCCGCTGCCG AAGACTCAGG CCTGCCGCTT TACCGCTACT 401TGGGCGGCGC AGGCCCGATG TCCCTGCCCG TACCGATGAT GAACGTCATC 451 AACGGCGGCGAACACGCCAA CAACAGCCTG AACATCCAAG AGTTTATGAT 501 TATGCCCGTC GGCGCAAAATCTTTCCGCGA AGCGTTGCGC TGCGGTGCGG 551 AAATTTTCCA CGCCTTGAAA AAACTGTGCGACAGCAAAGG CTTCCCGACC 601 ACAGTCGGCG ACGAAGGCGG TTTCGCCCCC AACCTGAACAGCCACAAAGA 651 AGCCCTGCAA CTGATGGTCG AGGCGACCGA AGCCGCCGGC TACAAAGCGG701 GCGAAGACGT ATTATTCGCA TTGGACTGCG CGTCCAGCGA GTTCTACAAA 751GACGGCAAAT ACCACTTGGA AGCCGAAGGC CGCTCCTACA CCAACGCGGA 801 ATTTGCCGAATATCTGGAAG GCCTGGTCAA CGAGTTCCCC ATCATCTCCA 851 TCGAAGACGG GATGGATGAAAACGACTGGG AAGGCTGGAA ACTGCTGACC 901 GAAAAACTGG GCGGCAAAGT CCAACTCGTTGGCGACGACC TCTTCGTTAC 951 CAACCCGAAA ATCCTTGCCG AAGGCATTGA AAAAGGCGTGGCAAACGCAC 1001 TATTGGTCAA AGTCAACCAA ATCGGTACTT TGAGTGAAAC CCTGAAAGCC1051 GTCGACTTAG CCAAACGCAA CCGCTACGCC AGCGTAATGA GCCACCGCTC 1101CGGCGAAACC GAAGACAGCA CCATTGCCGA CTTGGCAGTC GCCACCAACT 1151 GTATGCAGATCAAAACCGGT TCTTTGAGCC GTTCCGACCG CATGGCGAAA 1201 TACAACCAAC TGCTGCGTATCGAGGAAGAA TTGGCGGAAG CCGCCGACTA 1251 CCCCAGCAAA GCCGCATTCT ACCAACTGGGCAAATAAThis corresponds to the amino acid sequence <SEQ ID 2116; ORF 652-1.a>:

a652-1.pep 1 MSAIVDIFAR EILDSRGNPT VECDVLLESG VMGRAAVPSG ASTGQKEALE 51LRDGDKSRYS GKGVLKAVEH VNNQIAQALI GIDANEQSYI DQIMIELDGT 101 ENKGNLGANATLAVSMAVAR AAAEDSGLPL YRYLGGAGPM SLPVPMMNVI 151 NGGEHANNSL NIQEFMIMPVGAKSFREALR CGAEIFHALK KLCDSKGFPT 201 TVGDEGGFAP NLNSHKEALQ LMVEATEAAGYKAGEDVLFA LDCASSEFYK 251 DGKYHLEAEG RSYTNAEFAE YLEGLVNEFP IISIEDGMDENDWEGWKLLT 301 EKLGGKVQLV GDDLFVTNPK ILAEGIEKGV ANALLVKVNQ IGTLSETLKA351 VDLAKRNRYA SVMSHRSGET EDSTIADLAV ATNCMQIKTG SLSRSDRMAK 401YNQLLRIEEE LAEAADYPSK AAFYQLGK* m652-1/a652-1 99.8% identity in 428 aaoverlap         10        20        30        40        50        60m652-1 MSAIVDIFAREILDSRGNPTVECDVLLESGVMGRAAVPSGASTGQKEALELRDGDKSRYS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a652-1MSAIVDIFAREILDSRGNPTVECDVLLESGVMGRAAVPSGASTGQKEALELRDGDKSRYS        10        20        30        40        50        60        70        80        90       100       110       120 m652-1GKGVLKAVEHVNNQIAQALIGIDANEQSYIDQIMIELDGTENKGNLGANATLAVSMAVAR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a652-1GKGVLKAVEHVNNQIAQALIGIDANEQSYIDQIMIELDGTENKGNLGANATLAVSMAVAR        70        80        90       100       110       120       130       140       150       160       170       180 m652-1AAAEDSGLPLYRYLGGAGPMSLPVPMMNVINGGEHANNSLNIQEFMIMPVGAKSFREALR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a652-1AAAEDSGLPLYRYLGGAGPMSLPVPMMNVINGGEHANNSLNIQEFMIMPVGAKSFREALR       130       140       150       160       170       180       190       200       210       220       230       240 m652-1CGAEIFHALKKLCDSKGFPTTVGDEGGFAPNLNSHKEALQLMVEATEAAGYKAGEDVLFA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a652-1CGAEIFHALKKLCDSKGFPTTVGDEGGFAPNLNSHKEALQLMVEATEAAGYKAGEDVLFA       190       200       210       220       230       240       250       260       270       280       290       300 m652-1LDCASSEFYKDGKYHLEAEGRSYTNAEFAEYLEGLVNEFPIISIEDGMDENDWEGWKLLT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a652-1LDCASSEFYKDGKYHLEAEGRSYTNAEFAEYLEGLVNEFPIISIEDGMDENDWEGWKLLT       250       260       270       280       290       300       310       320       330       340       350       360 m652-1EKLGGRVQLVGDDLFVTNPKILAEGIEKGVANALLVKVNQIGTLSETLKAVDLAKRNRYA|||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||| a652-1EKLGGKVQLVGDDLFVTNPKILAEGIEKGVANALLVKVNQIGTLSETLKAVDLAKRNRYA       310       320       330       340       350       360       370       380       390       400       410       420 m652-1SVMSHRSGETEDSTIADLAVATNCMQIKTGSLSRSDRMAKYNQLLRIEEELAEAADYPSK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a652-1SVMSHRSGETEDSTIADLAVATNCMQIKTGSLSRSDRMAKYNQLLRIEEELAEAADYPSK       370       380       390       400       410       420       429m652-1 AAFYQLGKX ||||||||| a652-1 AAFYQLGKXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2117>:

g653.seq 1 ATGGCGGcgg aaccgatgcg gAtgccggag gtaAcgtaCG GTTTTTCCGG 51ATCGTTCGGG ATGGCGTTTT TGTtgacggT GATGTGCGCt ttgcccaAAG 101 CGGCTtcggcggctttgcCg gtgaTTTTCA TCGGTTGCAG GtcgacgaGG 151 AAaacgTGGC TTTCGGTGCGGCCGGAAacg atgcgCaaac cgCGTttaac 201 caactcttcc gcCATGACGG CAGCATTGATTTTCACTTGT TTTGCGTATT 251 GTTTGAactC GGGTTGcaac gcttctTTAA acgctACGGCTttgGCGGCG 301 ATAACGTgca tcaACGGAcc gCCTTGCAGG CTTGGGAAGA TGGAAGAGTT351 CAGCGCTTTT TCGTGGGTAT TGTCACGGCA CAAAATCACA CCGCCGCGAG 401GGCCGCGTAG GGTTTTGTGG GTGGTAGTGg ttACgaaGTc GCAGAatggc 451 ACGGGgttaggatattcgcc gccGGCAACC AgtccgGCAT AgThis corresponds to the amino acid sequence <SEQ ID 2118; ORF 653.ng>:

g653.pep 1 MAAEPMRMPE VTYGFSGSFG MAFLLTVMCA LPKAASAALP VIFIGCRSTR 51KTWLSVRPET MRKPRLTNSS AMTAALIFTC FAYCLNSGCN ASLNATALAA 101 ITCINGPPCRLGKMEEFSAF SWVLSRHKIT PPRGPRRVLW VVVVTKSQNG 151 TGLGYSPPAT SPA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2119>:

m653.seq 1 ATGGCAGCGG AGCCGATGCG GATGCCGGAG GTAACGAAGG GTTTTTCCGG 51ATCGTTCGGA ATGGCGTTTT TGTTGACGGT GATGTGCGCT TTGCCCAAAG 101 CGGCTTCGGCGGCTTTGCCG GTAATTTTCA TCGGTTGCAG GTCAACGAGG 151 AAAACGTGGC TTTCGGTGCGGCCGGAAACG ATGCGCAAAC CGCGTTTAAC 201 CAACTCTTCC GCCATGGCGG CTGCATTGATTTTCACTTGT TTTGCGTATT 251 GTTTGAACTC GGGTTGCAAT GCTTCTTTAA ACGCCACGGCTTTGGCGGCG 301 ATAACGTGCA TCAGCGGACC GCCTTGCAGG CTTGGGAAGA TGGAAGAGTT351 CAACGCTTTT TCGTGGGTAT TGTCGCGGCA CAAAATTACG CCGCCGCGAG 401GACCGCGCAG GGTTTTGTGG GTGGTGGTGG TCACGAAGTC GCAGAACGGC 451 ACCGGGTTGGGATATTCGCC GCCGGCAACC AGACCGGCAT AGThis corresponds to the amino acid sequence <SEQ ID 2120; ORF 653>:

m653.pep 1 MAAEPMRMPE VTKGFSGSFG MAFLLTVMCA LPKAASAALP VIFIGCRSTR 51KTWLSVRPET MRKPRLTNSS AMAAALIFTC FAYCLNSGCN ASLNATALAA 101 ITCISGPPCRLGKMEEFNAF SWVLSRHKIT PPRGPRRVLW VVVVTKSQNG 151 TGLGYSPPAT RPA*m653/g653 96.9% identity in 163 aa overlap        10        20        30        40        50        60 m653.pepMAAEPMRMPEVTKGFSGSFGMAFLLTVMCALPKAASAALPVIFIGCRSTRKTWLSVRPET|||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||| g653MAAEPMRMPEVTYGFSGSFGMAFLLTVMCALPKAASAALPVIFIGCRSTRKTWLSVRPET        10        20        30        40        50        60        70        80        90       100       110       120 m653.pepMRKPRLTNSSAMAAALIFTCFAYCLNSGCNASLNATALAAITCISGPPCRLGKMEEFNAF||||||||||||:|||||||||||||||||||||||||||||||:||||||||||||:|| a653MRKPRLTNSSAMTAALIFTCFAYCLNSGCNASLNATALAAITCINGPPCRLGKMEEFSAF        70        80        90       100       110       120       130       140       150       160 m653.pepSWVLSRHKITPPRGPRRVLWVVVVTKSQNGTGLGYSPPATRPAX|||||||||||||||||||||||||||||||||||||||| ||| a653SWVLSRHKITPPRGPRRVLWVVVVTKSQNGTGLGYSPPATSPAX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2121>:

a653.seq 1 ATGGCGGCGG AACCGATGCG GATGCCGGAG GTAACGAAGG GTTTTTCCGG 51ATCATTCGGG ATGGCGTTTT TGTTGACAGT GATGTGCGCT TTGCCCAAAG 101 CAGCTTCGGCGGCTTTGCCG GTAATTTTCA TCGGTTGCAG GTCAACGAGG 151 AAAACGTGGC TTTCGGTGCGGCCGGAAACG ATGCGCAAAC CGCGTTTAAC 201 CAACTCTTCC GCCATGGCGG CTGCATTGATTTTCACTTGT TTTGCGTATT 251 GTTTGAACTC GGGTTGCAAT GCTTCTTTAA ACGCCACGGCTTTGGCGGCG 301 ATAACGTGCA TCAGCGGGCC ACCTTGCAGG CTTGGGAAGA TGGAAGAGTT351 CAACGCTTTT TCGTGGGTAT TGTCGCGGCA CAAAATTACG CCGCCGCGAG 401GACCGCGCAG GGTTTTGTGG GTGGTGGTGG TAACGAAGTC GCAGAACGGC 451 ACGGGATTGGGATATTCGCC GCCGGCAACC AGACCGGCAT AGThis corresponds to the amino acid sequence <SEQ ID 2122; ORF 653.a>:

a653.pep 1 MAAEPMRMPE VTKGFSGSFG MAFLLTVMCA LPKAASAALP VIFIGCRSTR 51KTWLSVRPET MRKPRLTNSS AMAAALIFTC FAYCLNSGCN ASLNATALAA 101 ITCISGPPCRLGKMEEFNAF SWVLSRHKIT PPRGPRRVLW VVVVTKSQNG 151 TGLGYSPPAT RPA*m653/a653 100.0% identity in 163 aa overlap        10        20        30        40        50        60 m653.pepMAAEPMRMPEVTKGFSGSFGMAFLLTVMCALPKAASAALPVIFIGCRSTRKTWLSVRPET|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a653MAAEPMRMPEVTKGFSGSFGMAFLLTVMCALPKAASAALPVIFIGCRSTRKTWLSVRPET        10        20        30        40        50        60        70        80        90       100       110       120 m653.pepMRKPRLTNSSAMAAALIFTCFAYCLNSGCNASLNATALAAITCISGPPCRLGKMEEFNAF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a653MRKPRLTNSSAMAAALIFTCFAYCLNSGCNASLNATALAAITCISGPPCRLGKMEEFNAF        70        80        90       100       110       120       130       140       150       160 m653.pepSWVLSRHKITPPRGPRRVLWVVVVTKSQNGTGLGYSPPATRPAX|||||||||||||||||||||||||||||||||||||||||||| a653 SWVLSRHKIT PPRGPRRVLWVVVVTKSQNG TGLGYSPPAT RPAX        130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2123>:

g656.seq 1 ATGCCGCGTT TCTCCGGTTC GATTTCTTCG ATGATTTCCA TCGCGCGGAC 51TTTtggcGCG CCGGAGAGTG TGCcggcagg gAAGGTGGCG GCGAGGATGT 101 CCATATTGGTAACGCCCTCT TTCAAACAGc ctTCGACGTT GGAAACGATG 151 TGCATCACAT GGGAGTATTTTTCAATCACC ATTTTGTCGG TGACTTTGAC 201 TTCGCCTGTT TTGCTGATGC GTCCGACATCGTTGCGCCCC AAATCGATAA 251 GCATAACGTG TTCGGCgatt TCTTTGGCGT CGCTTAACAAATCTTGTTCG 301 TTGGCAAGGT CTTCGGCGGG GGTTTTGCCG CGCAGGCGCG TGCCGGCGAT351 GGGGCGGACG ATGACGTcat CGCGTTCGCG GCGGACGAGG ATTTCGGGCG 401AGGAACCGAC GATGTGGAAA TCGCCGAAAT CGTAGThis corresponds to the amino acid sequence <SEQ ID 2124; ORF 656.ng>:

g656.pep 1 MPRFSGSISS MISIARTFGA PESVPAGKVA ARMSILVTPS FKQPSTLETM 51CITWEYFSIT ILSVTLTSPV LLMRPTSLRP KSISITCSAI SLASLNKSCS 101 LARSSAGVLPRRRVPAMGRT MTSSRSRRTR ISGEEPTMWK SPKS*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2125>:

m656.seq 1 ATGCCGCGTT TGCTCGGTTC GACTTCTTCG ATGATTTCCA TGGCGCGGAC 51TTTGGGTGCG CCGGAGAGTG TGCCGGCAGG GAAGGTAGCG GCGAGGATGT 101 CCATGTTGGTCATGCCGTCT TTCAGACGGC CTTCGACGTT GGAAACGATG 151 TGCATTACAT GGGAGTATTTTTCAATCACC ATTTTGTCGG TAACTTTGAC 201 TTCGCCGGTT TTACTGATGC GGCCGACGTCGTTGCGTCCT AAGTCAATCA 251 ACATGACGTG TTCGGCGATT TCTTTGGCAT CGCTTAACAAATCTTGTTCG 301 TTGGCAAGGT CTTCGGCGGG GGTTTTGCCG CGCAGGCGCG TGCCGGCGAT351 GGGGCGGACG ATAACGTCGT TGCGTTCGCG TCGGACGAGG ATTTCGGGCG 401AGGAGCCGAC GATGTGGAAA TCGCCGAAAT CGTAGThis corresponds to the amino acid sequence <SEQ ID 2126; ORF 656>:

m656.pep 1 MPRLLGSTSS MISMARTLGA PESVPAGKVA ARMSMLVMPS FRRPSTLETM 51CITWEYFSIT ILSVTLTSPV LLMRPTSLRP KSINMTCSAI SLASLNKSCS 101 LARSSAGVLPRRRVPAMGRT ITSLRSRRTR ISGEEPTMWK SPKS*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m656/g656 91.0% identity in 144 aa overlap        10        20        30        40        50        60 m656.pepMPRLLGSTSSMISMARTLGAPESVPAGKVAARMSMLVMPSFRRPSTLETMCITWEYFSIT |||:|| |||||:|||:||||||||||||||||:|| |||::||||||||||||||||| g656MPRFSGSISSMISIARTFGAPESVPAGKVAARMSILVTPSFKQPSTLETMCITWEYFSIT        10        20        30        40        50        60        70        80        90       100       110       120 m656.pepILSVTLTSPVLLMRPTSLRPKSINMTCSAISLASLNKSCSLARSSAGVLPRRRVPAMGRT|||||||||||||||||||||||::||||||||||||||||||||||||||||||||||| g656ILSVTLTSPVLLMRPTSLRPKSISITCSAISLASLNKSCSLARSSAGVLPRRRVPAMGRT        70        80        90       100       110       120       130       140 m656.pep ITSLRSRRTRISGEEPTMWKSPKSX:|| ||||||||||||||||||||| g656 MTSSRSRRTRISGEEPTMWKSPKSX       130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2127>:

a656.seq 1 ATGCCGCGTT TGCTCGGTTC GACTTCTTCG ATGATTTCCA TGGCGCGGAC 51TTTGGGTGCG CCGGAGAGTG TGCCGGCAGG GAAGGTAGCG GCGAGGATGT 101 CCATGTTGGTCATGCCGTCT TTCAGACGGC CTTCGACGTT GGAAACGATG 151 TGCATTACAT GGGAGTATTTTTCAATCACC ATTTTGTCGG TAACTTTGAC 201 TTCGCCGGTT TTACTGATGC GGCCGACGTCGTTGCGTCCT AAGTCAATCA 251 ACATGACGTG TTCGGCGATT TCTTTGGCAT CGCTTAACAAATCTTGTTCG 301 TTGGCAAGGT CTTCGGCGGG GGTTTTGCCG CGCAGGCGCG TGCCGGCGAT351 GGGGCGGACG ATGACATCGT CGCGTTCGCG GCGGACGAGG ATTTCGGGCG 401AGGAGCCGAC GATGTGGAAA TCGCCGAAAT CGTAGThis corresponds to the amino acid sequence <SEQ ID 2128; ORF 656.a>:

a656.pep 1 MPRLLGSTSS MISMARTLGA PESVPAGKVA ARMSMLVMPS FRRPSTLETM 51CITWEYFSIT ILSVTLTSPV LLMRPTSLRP KSINMTCSAI SLASLNKSCS 101 LARSSAGVLPRRRVPAMGRT MTSSRSRRTR ISGEEPTMWK SPKS* m656/a656 98.6% identity in 144aa overlap         10        20        30        40        50        60m656.pep MPRLLGSTSSMISMARTLGAPESVPAGKVAARMSMLVMPSFRRPSTLETMCITWEYFSIT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a656MPRLLGSTSSMISMARTLGAPESVPAGKVAARMSMLVMPSFRRPSTLETMCITWEYFSIT        10        20        30        40        50        60        70        80        90       100       110       120 m656.pepILSVTLTSPVLLMRPTSLRPKSINMTCSAISLASLNKSCSLARSSAGVLPRRRVPAMGRT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a656ILSVTLTSPVLLMRPTSLRPKSINMTCSAISLASLNKSCSLARSSAGVLPRRRVPAMGRT        70        80        90       100       110       120       130        140 m656.pep ITSLRSRRTRISGEEPTMWKSPKSX:|| ||||||||||||||||||||| a656 MTSSRSRRTRISGEEPTMWKSPKSX       130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2129>:

g657.seq 1 ATGAACACAC CCCCCATCCT TCCTCCCGCC ATGCTCGGCA TCCTCGGCGG 51CGGACAATTa ggcagAATGT TTGCCGTTGC CGCTAAAACC ATGGGCTACA 101 AAGTAACCGTTCTCGATCCC GACCCGAATG CGCCGGCGGC GGAATTTGCC 151 GACCGCCATT TGTGCGCGCCGTTTGACGAC CGGGCCGCGT TGGACGAATT 201 GGCAAAATGC GCGGCGGTta cgACCGAATTTGAAAacgtc aaTGCCGACG 251 CGATGCGCTC TCTGGCAAAG CATACCAACG TTTCCCCCAGCGGCGACTGC 301 GTGTCCATTG CACAAAACCG CATTCAGGAA AAAGCGTGGA TACGCAAAGC351 AGGCTTGCAA ACCGCGCCGT ATCAGGCGGT TTGCAAGGCC GAAGACATTA 401CTGAAGCAAG CGCGCAATTT TTGCCCGGCA TCCTGAAAAC GGCTACGTTG 451 GGCTACGACGGCAAAGGTCA AATCCGCGTC AAAACGTTGG ACGAACTCAA 501 AGCCGCGTTT GCCGAACACGGCGGCGTGGA TTGCGTTTTG GAAAAAATGG 551 TGGACTTGCG CGGCGAGATT TCCGTGATCGTATGCCGTCT GAACGATGAA 601 AACGTGCAAA CCTTCGACCC CGCCGAAAAC ATCCACGAAAACGGCATCTT 651 GGCTTattcC ATCGTCcccg CGCGGCTGAG TGCCGACGTG CAGCAACAGG701 CGCGGCAGAC GGCGCAACgc tTGGCGGACG AATTGGATTA TGTCGGCgta 751TTGGCGGTAG AAATGTTTGT TGTCGGCGAC ACACATGAAT TGCTCGTCAA 801 TGAAACCGCCCCGCGCACGC ACAATTCCGG CCACCATACG ATAGATGCCT 851 GCGCCGCAGA CCAGTTCCAACAGCAGGTAC GCATTATGTG CAAcctGCCG 901 cccGccgACA CCAAATTATT aTCCCCttgCTGTATGGCGA ATATTTTGGg 951 CGACGTTTGG CAGGAAGATG GCGGCGAACC GGATTGGCTGCCGTTGCAAA 1001 GCCGGCCGAA TGCACACCTG CACCTATACG GAAAAAAAAC CGCACAGAAA1051 GGTCGGAAAA TGGGACACTT TaccgTTTTG ACCACCGATT CGGACaccgC 1101ATTTCAAGAA GCAAAAAAAC TGCATCAGTC CCTATAAThis corresponds to the amino acid sequence <SEQ ID 2130; ORF 657.ng>:

g657.pep 1 MNTPPILPPA MLGILGGGQL GRMFAVAAKT MGYKVTVLDP DPNAPAAEFA 51DRHLCAPFDD RAALDELAKC AAVTTEFENV NADAMRSLAK HTNVSPSGDC 101 VSIAQNRIQEKAWIRKAGLQ TAPYQAVCKA EDITEASAQF LPGILKTATL 151 GYDGKGQIRV KTLDELKAAFAEHGGVDCVL EKMVDLRGEI SVIVCRLNDE 201 NVQTFDPAEN IHENGILAYS IVPARLSADVQQQARQTAQR LADELDYVGV 251 LAVEMFVVGD THELLVNETA PRTHNSGHHT IDACAADQFQQQVRIMCNLP 301 PADTKLLSPC CMANILGDVW QEDGGEPDWL PLQSRPNAHL HLYGKKTAQK351 GRKMGHFTVL TTDSDTAFQE AKKLHQSL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2131>:

m657.seq 1 ATGAAAAACA TATCTCTTTC TCCGCCCGCC ATGCTTGGCA TCCTCGGCGG 51CGGACAATTA GGCAGAATGT TTACCGTTGC CGCCAAAACC ATGGGCTACA 101 AAGTAACCGTTCTCGACCCC GATCCGGACG CGCCGGCAGC AGAATTTGCC 151 GACCGCCATT TGTGCGCGCCGTTTAACGAC CAAGCTGCTT TGGACGAATT 201 GGCAAAATGC GCGGCGGTGA CCACTGAATTTGAAAACGTC AATGCCGATG 251 CGATGCGCTT TTTGGCAAAA CATACCAATG TTTCCCCTAGCGGCGATTGT 301 GTGGCGATTG CACAAAACCG CATTCAGGAA AAGGCATGGA TACGCAAAGC351 GGGATTGCAA ACCGCGCCGT ATCAAGTGGT TTGTAAGGCT GAAGACATCA 401CTGAAGCAAG CGCGCAATTT TTGCCCGGCA TCCTGAAAAC GGCTACGTTG 451 GGCTACGACGGCAAAGGTCA AATCCGCGTA AAAACATTGG ATGAACTCAA 501 AGCCGCGTTT GCCGAACACGGCGGCGTGGA TTGCGTTTTG GAAAAAATGG 551 TGGATTTGCG CAGTGAAATT TCCGTAATCGTATGCCGTTT GAACAATGAC 601 AACGTGCAAA CTTTCGACCC TGCCGAAAAC ATCCACGAAAACGGCATCTT 651 GGCTTATTCC ATCGTCCCCG CGCGACTGAG TGCCGACGTG CAGCAACAGG701 CGCGGCAGAT GGCGCAACGC TTGGCGGACG AATTGGATTA TGTCGGCGTA 751TTGGCGGTAG AAATGTTTGT TGTCGGTGAC ACGCATGAAT TGGTCGTCAA 801 CGAAATCGCCCCGCGCCCGC ACAATTCCGG ACACCATACG ATAGATGCCT 851 GCGCAGCAGA CCAGTTCCAGCAGCAGGTAC GCATTATGTG CAACCTGCCG 901 CCTGCCGATA CCAAATTACT GAGTTCTTGCTGTATGGCAA ATATTTTGGG 951 CGACGTTTGG CAGGAAGACG GCGGCGAACC GGATTGGCTGCCCTTGCAAA 1001 GCCATCCGAA TGCACACCTG CACCTTTACG GCAAAAAAAC CGCGCACAAA1051 GGGCGGAAAA TGGGACACTT TACCGTTTTA ACCACCGATT CGGACACCGC 1101ATTTCAAGAA GCAAAAAAAC TGCATCAGTC CCTATAAThis corresponds to the amino acid sequence <SEQ ID 2132; ORF 657>:

m657.pep 1 MKNISLSPPA MLGILGGGQL GRMFTVAAKT MGYKVTVLDP DPDAPAAEFA 51DRHLCAPFND QAALDELAKC AAVTTEFENV NADAMRFLAK HTNVSPSGDC 101 VAIAQNRIQEKAWIRKAGLQ TAPYQVVCKA EDITEASAQF LPGILKTATL 151 GYDGKGQIRV KTLDELKAAFAEHGGVDCVL EKMVDLRSEI SVIVCRLNND 201 NVQTFDPAEN IHENGILAYS IVPARLSADVQQQARQMAQR LADELDYVGV 251 LAVEMFVVGD THELVVNEIA PRPHNSGHHT IDACAADQFQQQVRIMCNLP 301 PADTKLLSSC CMANILGDVW QEDGGEPDWL PLQSHPNAHL HLYGKKTAHK351 GRKMGHFTVL TTDSDTAFQE AKKLHQSL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m657/g657 93.9% identity in 378 aa overlap        10        20        30        40        50        60 m657.pepMKNISLSPPAMLGILGGGQLGRMFTVAAKTMGYKVTVLDPDPDAPAAEFADRHLCAPFND |::  :|||||||||||||||||:|||||||||||||||||:|||||||||||||||:| g657MNTPPILPPAMLGILGGGQLGRMFAVAAKTMGYKVTVLDPDPNAPAAEFADRHLCAPFDD        10        20        30        40        50        60        70        80        90       100       110       120 m657.pepQAALDELAKCAAVTTEFENVNADAMRFLAKHTNVSPSGDCVAIAQNRIQEKAWIRKAGLQ:||||||||||||||||||||||||| ||||||||||||||:|||||||||||||||||| g657RAALDELAKCAAVTTEFENVNADAMRSLAKHTNVSPSGDCVSIAQNRIQEKAWIRKAGLQ        70        80        90       100       110       120       130       140       150       160       170       180 m657.pepTAPYQVVCKAEDITEASAQFLPGILKTATLGYDGKGQIRVKTLDELKAAFAEHGGVDCVL|||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||| g657TAPYQAVCKAEDITEASAQFLPGILKTATLGYDGKGQIRVKILDELKAAFAEHGGVDCVL       130       140       150       160       170       180       190       200       210       220       230       240 m657.pepEKMVDLRSEISVIVCRLNNDNVQTFDPAENIHENGILAYSIVPARLSADVQQQARQMAQR|||||||:||||||||||::|||||||||||||||||||||||||||||||||||| ||| g657EKMVDLRGEISVIVCRLNDENVQTFDPAENIHENGILAYSIVPARLSADVQQQARQTAQR       190       200       210       220       230       240       250       260       270       280       290       300 m657.pepLADELDYVGVLAVEMFVVGDTHELVVNEIAPRPHNSGHHTIDACAADQFQQQVRIMCNLP||||||||||||||||||||||||:||| ||| ||||||||||||||||||||||||||| g657LADELDYVGVLAVEMFVVGDTHELLVNETAPRTHNSGHHTIDACAADQFQQQVRIMCNLP       250       260       270       280       290       300       310       320       330       340       350       360 m657.pepPADTKLLSSCCMANILGDVWQEDGGEPDWLPLQSHPNAHLHLYGKKTAHKGRKMGHFTVL|||||||| |||||||||||||||||||||||||:|||||||||||||:||||||||||| g657PADTKLLSPCCMANILGDVWQEDGGEPDWLPLQSRPNAHLHLYGKKTAQKGRKMGHFTVL       310       320       330       340       350       360       370      379 m657.pep TTDSDTAFQEAKKLHQSLX |||||||||||||||||||g657 TTDSDTAFQEAKKLHQSLX        370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2133>:

a657.seq 1 ATGAAAAACA TATCTCTTTC TCCGCCCGCC ATGCTCGGCA TTCTTGGCGG 51CGGACAATTA GGCAGAATGT TTACTGTTGC TGCCAAAACC ATGGGCTACA 101 AAGTAACCGTACTCGATCCC AACCCGAATG CGCCGGCAGC GGAATTTGCC 151 GACCGCCATT TGTGTGCGCCGTTTGACAAC CAAACCGCTT TGGAAGAATT 201 GGCAAAATGT GCGGCTGTTA CGACCGAGTTCGAAAACGTC AATGCCGATG 251 CGATGCGTTT TCTCGCCAAA CATACCAATG TTTCCCCCAGCGGCGACTGC 301 GTTGCCATCG CGCAAAACCG CATTCAGGAA AAGGCATGGA TACGCAAAGC351 AGGCCTGCAA ACCGCGCCGT ATCAAGCAAT TTGCAAAGCC GAAGACATCA 401CTGAAGAAAG CATACAATTT CTGCCCGGCA TCCTGAAAAC CGCTACATTG 451 GGCTATGACGGCAAAGGCCA AATCCGCGTC AAAACGGTGG ATGAACTCAA 501 AGCCGCGTTT GCCGAACACCGCGGCGTGGA TTGCGTTTTG GAAAAAATGG 551 TGGACTTGCG CGGCGAAATT TCCGTTATCGTATGCCGTCT GAACAATGAC 601 AACGTGCAAA CTTTCGATCC TGCCGAAAAC ATTCACGAAAACGGTATCCT 651 CGCCTACTCC ATCGTCCCAG CCCGACTGAG TGCCGACATT CAGCAACAGG701 CGCGACAAAT GGCGCAGCGT TTGGCCGATG AATTGAACTA CGTCGGCGTA 751TTGGCGGTAG AAATGTTTGT TGTCGGCGAC ACGCATGAAT TGGTCGTCAA 801 CGAAATCGCGCCGCGTCCGC ACAATTCCGG CCACCATACC GTCGACGCCT 851 GCGCGGCAGA CCAATTCCAGCAACAGGTCC GCCTGATGTG CAACCTGCCA 901 CCTGCTGACA CCAAATTGCT GAGTTCTTGCTGTATGGCGA ATATTTTGGG 951 CGACGTTTGG CAGGAAGACG GCGGCGAACC GGATTGGTTTCCCCTGCAAA 1001 GCCGGCCGGA CGCGCACCTG CACCTTTACG GCAAAAAAAC CGCGCACAAA1051 GGGCGGAAAA TGGGACACTT TACCATTTTA AGCACCGATT CGGACACCGC 1101ATTTCAAGAA GCAAAAAAAC TGCATCAGTC CCTATAAThis corresponds to the amino acid sequence <SEQ ID 2134; ORF 657.a>:

a657.pep 1 MKNISLSPPA MLGILGGGQL GRMFTVAAKT MGYKVTVLDP NPNAPAAEFA 51DRHLCAPFDN QTALEELAKC AAVTTEFENV NADAMRFLAK HTNVSPSGDC 101 VAIAQNRIQEKAWIRKAGLQ TAPYQAICKA EDITEESIQF LPGILKTATL 151 GYDGKGQIRV KTVDELKAAFAEHRGVDCVL EKMVDLRGEI SVIVCRLNND 201 NVQTFDPAEN IHENGILAYS IVPARLSADIQQQARQMAQR LADELNYVGV 251 LAVEMFVVGD THELVVNEIA PRPHNSGHHT VDACAADQFQQQVRLMCNLP 301 PADTKLLSSC CMANILGDVW QEDGGEPDWF PLQSRPDAHL HLYGKKTAHK351 GRKMGHFTIL STDSDTAFQE AKKLHQSL* m657/a657 94.2% identity in 378 aaoverlap         10        20        30        40        50        60m657.pep MKNISLSPPAMLGILGGGQLGRMFTVAAKTMGYKVTVLDPDPDAPAAEFADRHLCAPFND||||||||||||||||||||||||||||||||||||||||:|:|||||||||||||||:: a657MKNISLSPPAMLGILGGGQLGRMFTVAAKTMGYKVTVLDPNPNAPAAEFADRHLCAPFDN        10        20        30        40        50        60        70        80        90       100       110       120 m657.pepQAALDELAKCAAVTTEFENVNADAMRFLAKHTNVSPSGDCVAIAQNRIQEKAWIRKAGLQ|:||:||||||||||||||||||||||||||||||||||||||||||||||||||||||| a657QTALEELAKCAAVTTEFENVNADAMRFLAKHTNVSPSGDCVAIAQNRIQEKAWIRKAGLQ        70        80        90       100       110       120       130       140       150       160       170       180 m657.pepTAPYQVVCKAEDITEASAQFLPGILKTATLGYDGKGQIRVKTLDELKAAFAEHGGVDCVL|||||::||||||| |||||||||||||||||||||||||:|||||||||| |||||| a657TAPYQAICKAEDITEESIQFLPGILKTATLGYDGKGQIRVKTVDELKAAFAEHRGVDCVL       130       140       150       160       170       180       190       200       210       220       230       240 m657.pepEKMVDLRSEISVIVCRLNNDNVQTFDPAENIHENGILAYSIVPARLSADVQQQARQMAQR|||||||:|||||||||||||||||||||||||||||||||||||||||:|||||||||| a657EKMVDLRGEISVIVCRLNNDNVQTFDPAENIHENGILAYSIVPARLSADIQQQARQMAQR       190       200       210       220       230       240       250       260       270       280       290       300 m657.pepLADELDYVGVLAVEMFVVGDTHELVVNEIAPRPHNSGHHTIDACAADQFQQQVRIMCNLP|||||:||||||||||||||||||||||||||||||||||:|||||||||||||:||||| a657LADELNYVGVLAVEMFVVGDTHELVVNEIAPRPHNSGHHTVDACAADQFQQQVRLMCNLP       250       260       270       280       290       300       310       320       330       340       350       360 m657.pepPADTKLLSSCCMANILGDVWQEDGGEPDWLPLQSHPNAHLHLYGKKTAHKGRKMGHFTVL|||||||||||||||||||||||||||||:||||:|:|||||||||||||||||||||:| a657PADTKLLSSCCMANILGDVWQEDGGEPDWFPLQSRPDAHLHLYGKKTAHKGRKMGHFTIL       310       320       330       340       350       360       370       379 m657.pep TTDSDTAFQEAKKLHQSLX :||||||||||||||||||a657 STDSDTAFQEAKKLHQSLX        370The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2135>:

g658.seq 1 ATGGTGGCCG GAATTGTGCG TGCGCGGGGC GGTTTCATTG ACGAGCAATT 51CATGTGTGTC GCCGACAACA AACATTTCTA CCGCCAAtac GCCGACATAA 101 TCCAATTCGTCCGCCAagcG TTGCGCCGTC TGCCGCGCCT GTTGCTGCAC 151 GTCGGCACTC AGCCGCGcgggGACGATGga atAAGCCAAG ATGCCGTTTT 201 CGTGGATGTT TTCGGCGGGG TCGAAGGTTTGCACGTTTTC ATCGTTCAGA 251 CGGCATACGA TCACGGAAAT CTCGCCGCGC AAGTCCACCATTTTTTCCAA 301 AACGCAATCC ACGCCGCCGT GTTCGGCAAA CGCGGCTTTG AGTTCGTCCA351 ACGTTTTGAC GCGGATTTGA CCTTTGCCGT CGTAGCCCAA CGTAGCCGTT 401TTCAGGATGC CGGGCAAAAA TTGCGCGCTT GCTTCAGTAA TGTCTTCGGC 451 CTTGCAAACCGCCTGATACG GCGCGGTTTG CAAGCCTGCT TTGCGTATCC 501 ACGCTTTTTC CTGAATGCGGTTTTGTGCAA TGGACACGCA GTCGCCGCTG 551 GGGGAAACGT TGGTATGCTT TGCCAGAGAGCGCATCGCGT CGGCAttgac 601 gtTTTCAAAT TCGGTcgtaA CCGCCGCGCA TTTTGCCAATTCGTCCAACG 651 CGGCCCGGTC GTCAAACGGC GCGCACAAAT GGCGGTCGGC AAATTCCGCC701 GCCGGCGCAT TCGGGTCGGG ATCGAGAACG GTTACTTTGT AGCCCATGGT 751TTTAGCGGCA ACGGCAAACA TTctgcctAAThis corresponds to the amino acid sequence <SEQ ID 2136; ORF 658.ng>:

g658.pep 1 MVAGIVRARG GFIDEQFMCV ADNKHFYRQY ADIIQFVRQA LRRLPRLLLH 51VGTQPRGDDG ISQDAVFVDV FGGVEGLHVF IVQTAYDHGN LAAQVHHFFQ 101 NAIHAAVFGKRGFEFVQRFD ADLTFAVVAQ RSRFQDAGQK LRACFSNVFG 151 LANRLIRRGL QACFAYPRFFLNAVLCNGHA VAAGGNVGML CQRAHRVGID 201 VFKFGRNRRA FCQFVQRGPV VKRRAQMAVGKFRRRRIRVG IENGYFVAHG 251 FSGNGKHSA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2137>:

m658.seq 1 ATGGTGTCCG GAATTGTGCG GGCGCGGGGC GATTTCGTTG ACGACCAATT 51CATGCGTGTC ACCGACAACA AACATTTCTA CCGCCAATAC GCCGACATAA 101 TCCAATTCGTCCGCCAAGCG TTGCGCCATC TGCCGCGCCT GTTGCTGCAC 151 GTCGGCACTC AGTCGCGCGGGGACGATGGA ATAAGCCAAG ATGCCGTTTT 201 CGTGGATGTT TTCGGCAGGG TCGAAAGTTTGCACGTTGTC ATTGTTCAAA 251 CGGCATACGA TTACGGAAAT TTCACTGCGC AAATCCACCATTTTTTCCAA 301 AACGCAATCC ACGCCGCCGT GTTCGGCAAA CGCGGCTTTG AGTTCATCCA351 ATGTTTTTAC GCGGATTTGA CCTTTGCCGT CGTAGCCCAA CGTAGCCGTT 401TTCAGGATGC CGGGCAAAAA TTGCGCGCTT GCTTCAGTGA TGTCTTCAGC 451 CTTACAAACCACTTGATACG GCGCGGTTTG CAATCCCGCT TTGCGTATCC 501 ATGCCTTTTC CTGAATGCGGTTTTGTGCAA TCGCCACACA ATCGCCGCTA 551 GGGGAAACAT TGGTATGTTT TGCCAAAAAGCGCATCGCAT CGGCATTGAC 601 GTTTTCAAAT TCAGTGGTCA CCGCCGCGCA TTTTGCCAATTCGTCCAAAG 651 CAGCTTGGTC GTTAAACGGC GCGCACAAAT GGCGGTCGGC AAATTCTGCT701 GCCGGCGCGT CCGGATCGGG GTCGAGAACG GTTACTTTGT AGCCCATGGT 751TTTGGCGGCA ACGGTAAACA TTCTGCCTAAThis corresponds to the amino acid sequence <SEQ ID 2138; ORF 658>:

m658.pep 1 MVSGIVRARG DFVDDQFMRV TDNKHFYRQY ADIIQFVRQA LRHLPRLLLH 51VGTQSRGDDG ISQDAVFVDV FGRVESLHVV IVQTAYDYGN FTAQIHHFFQ 101 NAIHAAVFGKRGFEFIQCFY ADLTFAVVAQ RSRFQDAGQK LRACFSDVFS 151 LTNHLIRRGL QSRFAYPCLFLNAVLCNRHT IAARGNIGMF CQKAHRIGID 201 VFKFSGHRRA FCQFVQSSLV VKRRAQMAVGKFCCRRVRIG VENGYFVAHG 251 FGGNGKHSA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m658/g658 82.2% identity in 259 aa overlap        10        20        30        40        50        60 m658.pepMVSGIVRARGDFVDDQFMRVTDNKHFYRQYADIIQFVRQALRHLPRLLLHVGTQSRGDDG||:||||||| |:|:||| |:|||||||||||||||||||||:||||||||||| ||||| g658MVAGIVRARGGFIDEQFMCVADNKHFYRQYADIIQFVRQALRRLPRLLLHVGTQPRGDDG        10        20        30        40        50        60        70        80        90       100       110       120 m658.pepISQDAVFVDVFGRVESLHVVIVQTAYDYGNFTAQIHHFFQNAIHAAVFGKRGFEFIQCFY|||||||||||| ||:||| |||||||:||::||:||||||||||||||||||||:| | g658ISQDAVFVDVFGGVEGLHVFIVQTAYDHGNLAAQVHHFFQNAIHAAVFGKRGFEFVQRFD        70        80        90       100       110       120       130       140       150       160       170       180 m658.pepADLTFAVVAQRSRFQDAGQKLRACFSDVFSLTNHLIRRGLQSRFAYPCLFLNAVLCNRHT||||||||||||||||||||||||||:||:|:|:|||||||: |||| :|||||||| |: g658ADLTFAVVAQRSRFQDAGQKLRACFSNVFGLANRLIRRGLQACFAYPRFFLNAVLCNGHA       130       140       150       160       170       180       190       200       210       220       230       240 m658.pepIAARGNIGMFCQKAHRIGIDVFKFSGHRRAFCQFVQSSLVVKRRAQMAVGKFCCRRVRIG:|| ||:||:||:|||:|||||||: :||||||||| : |||||||||||||  ||:|:| g658VAAGGNVGMLCQRAHRVGIDVFKFGRNRRAFCQFVQRGPVVKRRAQMAVGKFRRRRIRVG       190       200       210       220       230       240       250       260 m658.pep VENGYFVAHGFGGNGKHSAX :||||||||||:||||||||g658 IENGYFVAHGFSGNGKHSAX        250       260The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2139>:

a658.seq 1 ATGGTGGCCG GAATTGTGCG GACGCGGCGC GATTTCGTTG ACGACCAATT 51CATGCGTGTC GCCGACAACA AACATTTCTA CCGCCAATAC GCCGACGTAG 101 TTCAATTCATCGGCCAAACG CTGCGCCATT TGTCGCGCCT GTTGCTGAAT 151 GTCGGCACTC AGTCGGGCTGGGACGATGGA GTAGGCGAGG ATACCGTTTT 201 CGTGAATGTT TTCGGCAGGA TCGAAAGTTTGCACGTTGTC ATTGTTCAGA 251 CGGCATACGA TAACGGAAAT TTCGCCGCGC AAGTCCACCATTTTTTCCAA 301 AACGCAATCC ACGCCGCGGT GTTCGGCAAA CGCGGCTTTG AGTTCATCCA351 CCGTTTTGAC GCGGATTTGG CCTTTGCCGT CATAGCCCAA TGTAGCGGTT 401TTCAGGATGC CGGGCAGAAA TTGTATGCTT TCTTCAGTGA TGTCTTCGGC 451 TTTGCAAATTGCTTGATACG GCGCGGTTTG CAGGCCTGCT TTGCGTATCC 501 ATGCCTTTTC CTGAATGCGGTTTTGCGCGA TGGCAACGCA GTCGCCGCTG 551 GGGGAAACAT TGGTATGTTT GGCGAGAAAACGCATCGCAT CGGCATTGAC 601 GTTTTCGAAC TCGGTCGTAA CAGCCGCACA TTTTGCCAATTCTTCCAAAG 651 CGGTTTGGTT GTCAAACGGC GCACACAAAT GGCGGTCGGC AAATTCCGCT701 GCCGGCGCAT TCGGGTTGGG ATCGAGTACG GTTACTTTGT AGCCCATGGT 751TTTGGCAGCA ACAGTAAACA TTCTGCCTAAThis corresponds to the amino acid sequence <SEQ ID 2140; ORF 658.a>:

a658.pep 1 MVAGIVRTRR DFVDDQFMRV ADNKHFYRQY ADVVQFIGQT LRHLSRLLLN 51VGTQSGWDDG VGEDTVFVNV FGRIESLHVV IVQTAYDNGN FAAQVHHFFQ 101 NAIHAAVFGKRGFEFIHRFD ADLAFAVIAQ CSGFQDAGQK LYAFFSDVFG 151 FANCLIRRGL QACFAYPCLFLNAVLRDGNA VAAGGNIGMF GEKTHRIGID 201 VFELGRNSRT FCQFFQSGLV VKRRTQMAVGKFRCRRIRVG IEYGYFVAHG 251 FGSNSKHSA* m658/a658 75.3% identity in 259 aaoverlap         10        20        30        40        50        60m658.pep MVSGIVRARGDFVDDQFMRVTDNKHFYRQYADIIQFVRQALRHLPRLLLHVGTQSRGDDG||:||||:| ||||||||||:|||||||||||::||: |:|||| ||||:|||||  ||| a658MVAGIVRTRRDFVDDQFMRVADNKHFYRQYADVVQFIGQTLRHLSRLLLNVGTQSGWDDG        10        20        30        40        50        60        70        80        90       100       110       120 m658.pepISQDAVFVDVFGRVESLHVVIVQTAYDYGNFTAQIHHFFQNAIHAAVFGKRGFEFIQCFY:::|:|||:||||:||||||||||||| |||:||:|||||||||||||||||||||: | a658VGEDTVFVNVFGRIESLHVVIVQTAYDNGNFAAQVHHFFQNAIHAAVFGKRGFEFIHRFD        70        80        90       100       110       120       130       140       150       160       170       180 m658.pepADLTFAVVAQRSRFQDAGQKLRACFSDVFSLTNHLIRRGLQSRFAYPCLFLNAVLCNRHT|||:|||:|| | |||||||| | |||||:::| |||||||: |||||||||||| : :: a658ADLAFAVIAQCSGFQDAGQKLYAFFSDVFGFANCLIRRGLQACFAYPCLFLNAVLRDGNA       130       140       150       160       170       180       190       200       210       220       230       240 m658.pepIAARGNIGMFCQKAHRIGIDVFKFSGHRRAFCQFVQSSLVVKRRAQMAVGKFCCRRVRIG:|| |||||| :|:||||||||::: : |:|||| ||:||||||:||||||| |||:|:| a658VAAGGNIGMFGEKTHRIGIDVFELGRNSRTFCQFFQSGLVVKRRTQMAVGKFRCRRIRVG       190       200       210       220       230       240       250       260 m658.pep VENGYFVAHGFGGNGKHSAX :| |||||||||:|:|||||a658 IEYGYFVAHGFGSNSKHSAX        250       260The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2141>:

g661.seq 1 ATGCACATCG GCGGTTATTT TATCGACAAC CCCATCGCAC TTGCGCCGAT 51GGCGGGCATT GCCGACAAAC CCTTCCGCCG CCTCTGTCGG GCGTTTGGCG 101 CAGGTTGGGCGGTGTGCGAA ATGCTGGCCA GCGATCCGAC GCTCAGGAAT 151 ACCGGAAAAA CCCtgcaccgcagtgaTTTt gccgatgaag gCGGCATCGT 201 TGCCGTGCAG ATTGCCGGCA GCGACCccgaacaGATGGCG Gatgcggcgc 251 gttacAACGT CGGACTCGGG GCGCAGGTCA TCGACATcaaTATGGGCTGC 301 cccgccaaGA AAGTGTGCAA CGTCCAAGCC GGTAGCGCgc tGATGCAGGA351 CGAGccgctg gttgcCgcca tTTtggaggc ggtggtcAAG GCGGCGGgcg 401TACCCGTTAC cctCAAAACc cgtTtgggtt ggcacgacga cgatcaaaac 451 ctgcCcgccgtcgccaaaat cgccgaagat tgcggcattg ccgccCttgc 501 cgttccacgg gcgCGCgcgCACGCAAATGT ACAAAGGCGA GGCgcGTTAC 551 Gaactcatcg CCGAGACCAA AAGccgTCTGAACATCCCGG cctGggtCAA 601 CGGCGACATC actTCgccgc AAAAAGCCGC CGccgTCCTCAAACAAACCG 651 CCGCCGACGG CATCATGATA GGGCGCGGCG CGCAAGGCAG GCCGTGGTTT701 TTCCGCGATT TGAAGCATTA TGCCGAACAC GGCGTTTTAC CGCCTGCCTT 751GAGTTTGGCA GAATGCAGAG CCGCCATTTT GAACCACATC CGCGCCATGC 801 ACGCGTTTTATGGTGAGACC GTCGGTGTGC GCATCGCACG CAAACACATA 851 GGCTGGTACA TCGGCGAAATGCCCGACGGC GAACAGGCGC GGCGTGAThis corresponds to the amino acid sequence <SEQ ID 2142; ORF 661.ng>:

g661.pep 1 MHIGGYFIDN PIALAPMAGI ADKPFRRLCR AFGAGWAVCE MLASDPTLRN 51TGKTLHRSDF ADEGGIVAVQ IAGSDPEQMA DAARYNVGLG AQVIDINMGC 101 PAKKVCNVQAGSALMQDEPL VAAILEAVVK AAGVPVTLKT RLGWHDDDQN 151 LPAVAKIAED CGIAALAVPRARAHANVQRR GALRTHRRDQ KPSEHPGLGQ 201 RRHHFAAKSR RRPQTNRRRR HHDRARRARQAVVFPRFEAL CRTRRFTACL 251 EFGRMQSRHF EPHPRHARVL WXDRRCAHRT QTHRLVHRRNARRRTGAA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2143>:

m661.seq 1 ATGCACATCG GCGGCTATTT TATCGACAAC CCCATCGCAC TTGCGCCGAT 51GGCGGGCATT ACCGACAAAC CGTTCCGCCG ACTTTGCCGA GATTTTGGCG 101 CAGGTTGGGCGGTGTGCGAA ATGCTGACCA GCGACCCGAC GCTCAGAAAT 151 ACTAGAAAAA CCTTGCACCGCAGCGATTTT GCCGATGAAG GCGGCATTGT 201 TGCCGTGCAG ATTGCCGGAA GCGATCCGCAGCAGATGGCG GATGCCGCGC 251 GTTACAACGT CAGCCTTGGG GCGCAGCTTA TCGACATCAACATGGGCTGT 301 CCCGCTAAAA AAGTCTGCAA TGTCCAAGCC GGTAGCGCGC TGATGCAGAA351 CGAGCCGCTG GTTGCCGCCA TTTTGGAAGC CGTCGTCCGT GCGGCAGGCG 401TACCCGTTAC CCTCAAAACC CGTTTGGGTT GGCACGACGA CCATCAAAAC 451 CTGCCCGTCATCGCCAAAAT CGCCGAAGAT TGCGGCATCG CCGCCCTTGC 501 CGTCC.ACGG ACGCACGCGTACGCAAATGT ACAAAGGCGA AGCGCGTTAC 551 GAACTCATCG CCGAAACCAA ATGCCGTCTGAACATCCCGG TCTGGGTCAA 601 CGGCGACATT ACTTCGCCGC AAAAAGCCCA AGCCGTCCTCAAACAAACCG 651 CCGCCGACGG CATTATGATA GGGCGCGGCG CGCAAGGCAG GCCGTGGTTC701 TTCCGCGATT TGAAACATTA TGCCGAACAC GGTGTTTTGC CGCCTGCCTT 751GAGTTTGGCA GAATGCGCCG CCGCTATTTT GAACCACATC CGCGCCATAC 801 ACGCGTTTTACGGCGACACC GCCGGTGTGC GCATCGCACG CAAACACATA 851 GGCTGGTACA TCGACGAAATGCCCGACGGC GAACAGACAC GTCGTGAThis corresponds to the amino acid sequence <SEQ ID 2144; ORF 661>:

m661.pep 1 MHIGGYFIDN PIALAPMAGI TDKPFRRLCR DFGAGWAVCE MLTSDPTLRN 51TRKTLHRSDF ADEGGIVAVQ IAGSDPQQMA DAARYNVSLG AQLIDINMGC 101 PAKKVCNVQAGSALMQNEPL VAAILEAVVR AAGVPVTLKT RLGWHDDHQN 151 LPVIAKIAED CGIAALAVXRTHAYANVQRR SALRTHRRNQ MPSEHPGLGQ 201 RRHYFAAKSP SRPQTNRRRR HYDRARRARQAVVLPRFETL CRTRCFAACL 251 EFGRMRRRYF EPHPRHTRVL RRHRRCAHRT QTHRLVHRRNARRRTDTS*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m661/g661 88.5% identity in 295 aa overlap        10        20        30        40        50        60 m661.pepMHIGGYFIDNPIALAPMAGITDKPFRRLCRDFGAGWAVCEMLTSDPTLRNTRKTLHRSDF||||||||||||||||||||:||||||||| |||||||||||:|||||||| |||||||| g661MHIGGYFIDNPIALAPMAGIADKPFRRLCRAFGAGWAVCEMLASDPTLRNTGKTLHRSDF        10        20        30        40        50        60        70        80        90       100       110       120 m661.pepADEGGIVAVQIAGSDPQQMADAARYNVSLGAQLIDINMGCPAKKVCNVQAGSALMQNEPL||||||||||||||||:||||||||||:||||:|||||||||||||||||||||||:||| g661ADEGGIVAVQIAGSDPEQMADAARYNVGLGAQVIDINMGCPAKKVCNVQAGSALMQDEPL        70        80        90       100       110       120       130       140       150       160       170       180 m661.pepVAAILEAVVRAAGVPVTLKTRLGWHDDHQNLPVIAKIAEDCGIAALAVXRTHAYANVQRR|||||||||:||||||||||||||||| ||||::|||||||||||||| |::|:|||||| g661VAAILEAVVKAAGVPVTLKTRLGWHDDDQNLPAVAKIAEDCGIAALAVPRARAHANVQRR       130       140       150       160       170       180       190       200       210       220       230       240 m661.pepSALRTHRRNQMPSEHPGLGQRRHYFAAKSPSRPQTNRRRRHYDRARRARQAVVLPRFETL:|||||||:| ||||||||||||:|||||  ||||||||||:|||||||||||:||||:| g661GALRTHRRDQKPSEHPGLGQRRHHFAAKSRRRPQTNRRRRHHDRARRARQAVVFPRFEAL       190       200       210       220       230       240       250       260       270       280       290      299 m661.pepCRTRCFAACLEFGRMRRRYFEPHPRHTRVLRRHRRCAHRTQTHRLVHRRNARRRTDTSX|||| |:||||||||: |:|||||||:|||   |||||||||||||||||||||| g661CRTRRFTACLEFGRMQSRHFEPHPRHARVLWXDRRCAHRTQTHRLVHRRNARRRTGAAX       250       260       270       280       290The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2145>:

a661.seq 1 ATGCACATCG GCGGCTATTT TATCGACAAC CCCATCGCAC TTGCGCCGAT 51GGCGGGCATT ACCGACAAAC CGTTCCGCCG ACTTTGCCGA GATTTTGGCG 101 CAGGTTGGGCGGTGTGCGAA ATGCTGACCA GCGACCCGAC GCTCAGAAAT 151 ACTAGAAAAA CCTTGCACCGCAGCGATTTT GCCGATGAAG GCGGCATTGT 201 TGCCGTGCAG ATTGCCGGAA GCGATCCGCAGCAGATGGCG GATGCCGCGC 251 GTTACAACGT CAGCCTTGGG GCGCAGCTTA TCGACATCAACATGGGCTGT 301 CCCGCTAAAA AAGTCTGCAA TGTCCAAGCC GGTAGCGCGC TGATGCAGAA351 CGAGCCGCTG GTTGCCGCCA TTTTGGAGGC GGTGGTCAAA GCGGCGGGCG 401TACCCGTTAC CCTCAAAACC CGTTTGGGTT GGCACGACGA CCATCAAAAC 451 CTGCCCGTCATCGCCAAAAT CGCCGAAGAT TGCGGCATTG CCGCCCTTGC 501 CG.TCCACGG ACGCACGCGCACGCAAATGT ACAAAGGCGA AGCGGCTTAC 551 GACCTGATTG CCGAAACCAA ATGCCGTCTGAACATCCCGG TCTGGGTCAA 601 CGGCGACATT ACCTCGCCGC AAAAAGCCCA AGCCGTCCTCAAACAAACCG 651 CCGCAGACGG CATTATGATA GGGCGCGGCG CGCAAGGCAG ACCGTGGTTC701 TTCCGCGATT TGAAACATTA CGCCGAACAC GGTGTTTTAC CGCCTGCCTT 751GAGTTTGGCA GAATGTACCG CCACTATTTT GAACCACATC CGAGCCATGC 801 ACGCGTTTTACGGCGACACC GCCGGTGTGC GCATCGCACG CAAACACATA 851 GGCTGGTACA TCGACGAAATGCCCGACGGC GAACAGACAC GTCGTGAThis corresponds to the amino acid sequence <SEQ ID 2146; ORF 661.a>:

a661.pep 1 MHIGGYFIDN PIALAPMAGI TDKPFRRLCR DFGAGWAVCE MLTSDPTLRN 51TRKTLHRSDF ADEGGIVAVQ IAGSDPQQMA DAARYNVSLG AQLIDINMGC 101 PAKKVCNVQAGSALMQNEPL VAAILEAVVK AAGVPVTLKT RLGWHDDHQN 151 LPVIAKIAED CGIAALAXPRTHAHANVQRR SGLRPDCRNQ MPSEHPGLGQ 201 RRHYLAAKSP SRPQTNRRRR HYDRARRARQTVVLPRFETL RRTRCFTACL 251 EFGRMYRHYF EPHPSHARVL RRHRRCAHRT QTHRLVHRRNARRRTDTS* m661/a661 94.6% identity in 298 aa overlap        10        20        30        40        50        60 m661.pepMHIGGYFIDNPIALAPMAGITDKPFRRLCRDFGAGWAVCEMLTSDPTLRNTRKTLHRSDF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a661MHIGGYFIDNPIALAPMAGITDKPFRRLCRDFGAGWAVCEMLTSDPTLRNTRKTLHRSDF        10        20        30        40        50        60        70        80        90       100       110       120 m661.pepADEGGIVAVQIAGSDPQQMADAARYNVSLGAQLIDINMGCPAKKVCNVQAGSALMQNEPL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a661ADEGGIVAVQIAGSDPQQMADAARYNVSLGAQLIDINMGCPAKKVCNVQAGSALMQNEPL        70        80        90       100       110       120       130       140       150       160       170       180 m661.pepVAAILEAVVRAAGVPVTLKTRLGWHDDHQNLPVIAKIAEDCGIAALAVXRTHAYANVQRR|||||||||:|||||||||||||||||||||||||||||||||||||  ||||:|||||| a661VAAILEAVVKAAGVPVTLKTRLGWHDDHQNLPVIAKIAEDCGIAALAXPRTHAHANVQRR       130       140       150       160       170       180       190       200       210       220       230       240 m661.pepSALRTHRRNQMPSEHPGLGQRRHYFAAKSPSRPQTNRRRRHYDRARRARQAVVLPRFETL|:||   |||||||||||||||||:|||||||||||||||||||||||||:||||||||| a661SGLRPDCRNQMPSEHPGLGQRRHYLAAKSPSRPQTNRRRRHYDRARRARQTVVLPRFETL       190       200       210       220       230       240       250       260       270       280       290      299 m661.pepCRTRCFAACLEFGRMRRRYFEPHPRHTRVLRRHRRCAHRTQTHRLVHRRNARRRTDTSX|||||:|||||||| |:|||||| |:|||||||||||||||||||||||||||||||| a661RRTRCFTACLEFGRMYRHYFEPHPSHARVLRRHRRCAHRTQTHRLVHRRNARRRTDTSX       250       260       270       280       290The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2147>:

g663.seq 1 ATGTGTACCG AGATGAAATT TATATTTTTT GTACTGTATG TTTTGCAGTT 51TCTGCCGTTT GCGCTGCTGC ACAAGATTGC CGGCCTGATC GGTTCGCTTG 101 CCTACCTTCTGGTCAAACCG CGCCGCCGTA TCGGCGAAAT CAATTTGGCA 151 AAATGTTTTC CCGAATGGGACGAAGAAAAG CGTAAAACCG TGTTGAAACA 201 GCATTTCAAA CACATGGCAA AACTGATGCTCGAATACGGC TTATATTGGT 251 ACGCGtctGC CAAATGCCTG AAATCGCTGG TGCGCTACCGCAATAAGCAT 301 TATTTGGACG ACGCGCTGGC GGCGGGGGAA AAAGTCATCA TCCTGTACCC351 GCACTTTACC GCGTTCGAGA TGGCGGTGTA CGCGCTTAAT CAGGATGTCC 401CGCTGATCAG TATGTATTCC CACCAAAAAA ACAAGATATT GGACGAACAG 451 ATTTTGAAAggccgcaACCG CTATCACAAC GTCTTCCTTA TCGGGCGCAC 501 CGAagggctg cgCGCCCtcgTCAAACAGTT CCGCAAAAGC AGTGCGCCGT 551 TCCTGTATCT GCCCGATCAG GATTTCGGACGCAACAATTC GGTTTTTGTG 601 GATTTTTTCG GCATtcagaC GGCAACGATT ACCGGCTTGAGCCGCATTGC 651 CGCGCTTGCA AATGCAAAAG TGATACCCGC CATTCCCGTC CGCGAGGCGG701 ACAATACGGT TACATTGCAA TTCTATCCCG CTTGGAAATC CTTTCCGAGT 751GAAGACGCGC AAGCCGACGC GCAACGTATG AACCGCTTTA TCGAAGAACG 801 CGTGCGCGAACACCCGGAAC AATATTTCTG GCTGCACAAG CGTTTCAAAA 851 CCCGTCCGGA AGGCAGCCCCGATTTTTACT GAThis corresponds to the amino acid sequence <SEQ ID 2148; ORF 663.ng>:

g663.pep 1 MCTEMKFIFF VLYVLQFLPF ALLHKIAGLI GSLAYLLVKP RRRIGEINLA 51KCFPEWDEEK RKTVLKQHFK HMAKLMLEYG LYWYASAKCL KSLVRYRNKH 101 YLDDALAAGEKVIILYPHFT AFEMAVYALN QDVPLISMYS HQKNKILDEQ 151 ILKGRNRYHN VFLIGRTEGLRALVKQFRKS SAPFLYLPDQ DFGRNNSVFV 201 DFFGIQTATI TGLSRIAALA NAKVIPAIPVREADNTVTLQ FYPAWKSFPS 251 EDAQADAQRM NRFIEERVRE HPEQYFWLHK RFKTRPEGSPDFY*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2149>:

m663.seq 1 ATGTGTATCG AGATGAAATT TATATTTTTT GTACTGTATG TTTTGCAGTT 51TCTGCCGTTT GCGCTGCTGC ACAAGATTGC CGACCTGACG GGTTTGCTTG 101 CCTACCTTCTGGTCAAACCG CGCCGCCGTA TCGGCGAAAT CAATTTGGCA 151 AAATGTTTTT CCGAATGGAGTGAGGAAAAG CGTAAAACCG TGTTGAAACA 201 GCATTTCAAA CACATGGCGA AACTGATGTTGGAATACGGT TTATATTGGT 251 ACGCGCCTGC CGGACGTTTG AAATCGCTGG TGCGCTACCGCAATAAGCAT 301 TATTTGGACG ACGCGCTGGC GGCGGGGGAA AAAGTCATCA TCCTGTATCC351 GCACTTCACC GCGTTCGAGA TGGCGGTGTA CGCGCTTAAT CAGGATATCC 401CGCTGATCAG TATGTATTCC CATCAAAAAA ACAAGATATT GGACGAACAG 451 ATTTTGAAAGGCCGCAACCG CTATCACAAC GTCTTCCTTA TCGGGCGCAC 501 CGAAGGGCTG CGCGCCCTCGTCAAACAGTT CCGCAAAAGC AGCGCGCCGT 551 TTCTGTATCT GCCCGATCAG GATTTCGGACGCAACGATTC GGTTTTTGTG 601 GATTTTTTCG GTATTCAGAC GGCAACGATT ACCGGATTGAGCCGCATTGC 651 CGCGCTTGCA AATGCAAAAG TGATACCCGC CATTCCCGTC CGCGAGGCAG701 ACAATACGGT TACATTGCAT TTCTACCCTG CTTGGAAATC CTTTCCGGGT 751GAAGACGCGA AAGCCGACGC GCAGCGCATG AACCGTTTTA TCGAAGACAG 801 GGTGCGCGAACATCCGGAAC AATATTTTTG GCTGCACAAG CGTTTTAAAA 851 CCCGTCCGGA AGGCAGCCCCGATTTTTACT GAThis corresponds to the amino acid sequence <SEQ ID 2150; ORF 663>:

m663.pep 1 MCIEMKFIFF VLYVLQFLPF ALLHKIADLT GLLAYLLVKP RRRIGEINLA 51KCFSEWSEEK RKTVLKQHFK HMAKLMLEYG LYWYAPAGRL KSLVRYRNKH 101 YLDDALAAGEKVIILYPHFT AFEMAVYALN QDIPLISMYS HQKNKILDEQ 151 ILKGRNRYHN VFLIGRTEGLRALVKQFRKS SAPFLYLPDQ DFGRNDSVFV 201 DFFGIQTATI TGLSRIAALA NAKVIPAIPVREADNTVTLH FYPAWKSFPG 251 EDAKADAQRM NRFIEDRVRE HPEQYFWLHK RFKTRPEGSPDFY*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m663/g663 94.9% identity in 293 aa overlap        10        20        30        40        50        60 m663.pepMCIEMKFIFFVLYVLQFLPFALLHKIADLTGLLAYLLVKPRRRIGEINLAKCFSEWSEEK|| |||||||||||||||||||||||| | | ||||||||||||||||||||| ||:||| g663MCTEMKFIFFVLYVLQFLPFALLHKIAGLIGSLAYLLVKPRRRIGEINLAKCFPEWDEEK        10        20        30        40        50        60        70        80        90       100       110       120 m663.pepRKTVLKQHFKHMAKLMLEYGLYWYAPAGRLKSLVRYRNKHYLDDALAAGEKVIILYPHFT||||||||||||||||||||||||| |  ||||||||||||||||||||||||||||||| g663RKTVLKQHFKHMAKLMLEYGLYWYASAKCLKSLVRYRNKHYLDDALAAGEKVIILYPHFT        70        80        90       100       110       120       130       140       150       160       170       180 m663.pepAFEMAVYALNQDIPLISMYSHQKNKILDEQILKGRNRYHNVFLIGRTEGLRALVKQFRKS||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| g663AFEMAVYALNQDVPLISMYSHQKNKILDEQILKGRNRYHNVFLIGRTEGLRALVKQFRKS       130       140       150       160       170       180       190       200       210       220       230       240 m663.pepSAPFLYLPDQDFGRNDSVFVDFFGIQTATITGLSRIAALANAKVIPAIPVREADNTVTLH|||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||: g663SAPFLYLPDQDFGRNNSVFVDFFGIQTATITGLSRIAALANAKVIPAIPVREADNTVTLQ       190       200       210       220       230       240       250       260       270       280       290 m663.pepFYPAWKSFPGEDAKADAQRMNRFIEDRVREHPEQYFWLHKRFKTRPEGSPDFYX|||||||||:|||:|||||||||||:|||||||||||||||||||||||||||| g663FYPAWKSFPSEDAQADAQRMNRFIEERVREHPEQYFWLHKRFKTRPEGSPDFYX       250       260       270       280       290The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2151>:

a663.seq 1 ATGTGTATCG AGATGAAATT TATATTTTTT GTACTGTATG TTTTGCAGTT 51TCTGCCGTTT GCGCTGCTGC ACAAACTTGC TGATCTGACA GGCTTGCTCG 101 CCTACCTTTTGGTCAAACCC CGCCGCCGTA TCGGCGAAAT CAATTTGGCA 151 AAATGCTTTC CCGAGTGGGACGGAAAAAAG CGTAAAACCG TGTTGAAACA 201 GCATTTCAAA CATATGGCGA AACTGATGTTGGAATACGGT TTATATTGGT 251 ACGCGCCCGC CGGGCGTTTG AAATCACTGG TGCGCTACCGCAACAAACAT 301 TATTTGGACG ACGCTCTGGC GGCAGGGGAA AAAGTCATCA TCCTGTATCC351 GCACTTCACC GCGTTCGAGA TGGCGGTGTA CGCGCTCAAT CAGGATGTTC 401CGCTGATCAG TATGTATTCC CACCAAAAAA ACAAGATATT GGACGAACAG 451 ATTTTGAAAGGCCGCAACCG CTATCACAAC GTTTTCCTTA TCGGGCGCAC 501 CGAAGGGCTG CGCGCCCTCGTCAAACAGTT CCGCAAAAGC AGCGCGCCGT 551 TTCTGTATCT GCCCGATCAG GATTTCGGACGCAACGATTC GGTTTTTGTC 601 GATTTCTTCG GTATTCGGAC GGCAACGATT ACCGGCTTGAGCCGCATTGC 651 CGCGCTTGCA AATGCAAAAG TGATACCCGC CATCCCTGTC CGCGAGGCGG701 ACAATACGGT TACATTGCAT TTCTACCCTG CTTGGGAATC CTTTCCGAGT 751GAAGATGCGC AGGCCGACGC GCAGCGCATG AACCGTTTTA TCGAGGAACG 801 CGTGCGCGAACATCCCGAGC AGTATTTTTG GCTGCACAAG CGTTTCAAAA 851 CCCGTCCGGA AGGCAGCCCCGATTTTTACT GAThis corresponds to the amino acid sequence <SEQ ID 2152; ORF 663.a>:

a663.pep 1 MCIEMKFIFF VLYVLQFLPF ALLHKLADLT GLLAYLLVKP RRRIGEINLA 51KCFPEWDGKK RKTVLKQHFK HMAKLMLEYG LYWYAPAGRL KSLVRYRNKH 101 YLDDALAAGEKVIILYPHFT AFEMAVYALN QDVPLISMYS HQKNKILDEQ 151 ILKGRNRYHN VFLIGRTEGLRALVKQFRKS SAPFLYLPDQ DFGRNDSVFV 201 DFFGIRTATI TGLSRIAALA NAKVIPAIPVREADNTVTLH FYPAWESFPS 251 EDAQADAQRM NRFIEERVRE HPEQYFWLHK RFKTRPEGSPDFY* m663/a663 96.2% identity in 293 aa overlap        10        20        30        40        50        60 m663.pepMCIEMKFIFFVLYVLQFLPFALLHKIADLTGLLAYLLVKPRRRIGEINLAKCFSEWSEEK|||||||||||||||||||||||||:||||||||||||||||||||||||| ||: :| a663MCIEMKFIFFVLYVLQFLPFALLHKLADLTGLLAYLLVKPRRRIGEINLAKCFPEWDGKK        10        20        30        40        50        60        70        80        90       100       110       120 m663.pepRKTVLKQHFKHMAKLMLEYGLYWYAPAGRLKSLVRYRNKHYLDDALAAGEKVIILYPHFT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a663RKTVLKQHFKHMAKLMLEYGLYWYAPAGRLKSLVRYRNKHYLDDALAAGEKVIILYPHFT        70        80        90       100       110       120       130       140       150       160       170       180 m663.pepAFEMAVYALNQDIPLISMYSHQKNKILDEQILKGRNRYHNVFLIGRTEGLRALVKQFRKS||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| a663AFEMAVYALNQDVPLISMYSHQKNKILDEQILKGRNRYHNVFLIGRTEGLRALVKQFRKS       130       140       150       160       170       180       190       200       210       220       230       240 m663.pepSAPFLYLPDQDFGRNDSVFVDFFGIQTATITGLSRIAALANAKVIPAIPVREADNLVTLH|||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||| a663SAPFLYLPDQDFGRNDSVFVDFFGIRTATITGLSRIAALANAKVIPAIPVREADNLVTLH       190       200       210       220       230       240       250       260       270       280       290 m663.pepFYPAWKSFPGEDAKADAQRMNRFIEDRVREHPEQYFWLHKRFKTRPEGSPDFYX|||||:|||:|||:|||||||||||:|||||||||||||||||||||||||||| a663FYPAWESFPSEDAQADAQRMNRFIEERVREHPEQYFWLHKRFKTRPEGSPDFYX       250       260       270       280       290The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2153>:

g664.seq 1 ATGATACATC CGCACCACTT CCGCGCCTTT TTCATAAACG GTCATGGTGT 51AGAAATTGTT CATCTCCTCA TAGCTGAcgg gGCGCACCGG ATGGGCGGTC 101 GGGCCTGCGTCTTCGGGGAA CTGGTTCTGG CGCAGCAGGC GGATGTTCTC 151 GATGCGGCGC ACGGCGCGGCCGGCGCGGTC GCCGGAAAAC TCTTGGTCGC 201 GGAACACGGT CAGCCCTTCC TTCAGCGAAAGCTGGAACCA GTCGCGGCAG 251 GTTACGCGGT TGCCCGTCCA GTTGTGGAAA TATTCGTGTCCGACCACGGA 301 TTCAATGCCT TCGAAATCGG TATCGGTGGC GGTGCGGCTG TCGGCGAGGA351 CGAACTTGGT GTTAAAAATG TTCAAACCCT TGTTTTCCAT CGCGCCCATA 401TTGAAATCGC CTACGGCGAC GACCATGAaa atatccaagt cataTTCcaa 451 cCcgaagcgcgtttcgtcCc acttcatcgC gtTTTTTCAA cgaTTCCACG 501 GCAAAGCCGA CCTTGGGTTTGTCCGCTTCG GTGGTGTAAA ACTCGATTTT 551 GAThis corresponds to the amino acid sequence <SEQ ID 2154; ORF 664.ng>:

g664.pep 1 MIHPHHFRAF FINGHGVEIV HLLIADGAHR MGGRACVFGE LVLAQQADVL 51DAAHGAAGAV AGKLLVAEHG QPFLQRKLEP VAAGYAVARP VVEIFVSDHG 101 FNAFEIGIGGGAAVGEDELG VKNVQTLVFH RAHIEIAYGD DHENIQVIFQ 151 PEARFVPLHR VFSTIPRQSRPWVCPLRWCK TRF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2155>:

m664.seq 1 GTGATACATC CGCACTACTT CCGCGCCTTT TTCATAAACG GTCATGGTGT 51AGAAATTGTT CATCTCCTCA TAGCTGGCGG GGCGCACCGG ATGGGCGGTC 101 GGGCCTGCGTCTTCGGGGAA CTGGTGCTGG CGCAGCAGGC GGATGTTTTC 151 GATGCGGCGC ACGGCGCGGCTGGCGCGGTC GCCGGAAAAT TCTTGGTCGC 201 GGAACACGGT CAGCCCTTCC TTCAGCGAAAGCTGGAACCA GTCGCGGCAG 251 GTTACGCGGT TGCCCGTCCA GTTGTGGAAA TACTCGTGTCCGACCACGGA 301 TTCGATGCCT TCGAAATCGG TATCGGTGGC GGTGCGGCTG TCGGCAAGGA351 CGAACTTGGT GTTAAAGATG TTCAAACCCT TGTTTTCCAT CGCGCCCATA 401TTGAAATCGC CCACGGCGAC GACCATGAAA ATATCCAAGT CGTATTCCAA 451 ACCGAAGCGCGTTTCGTCCC ATTTCATCGC GTTTTT.CAA CGATTCCACG 501 GCAAAGCCGA CCTTGGGCTTGTCCGCTTCG GTGGTGTAAA ACTCGATTTT 551 GAThis corresponds to the amino acid sequence <SEQ ID 2156; ORF 664>:

m664.pep 1 VIHPHYFRAF FINGHGVEIV HLLIAGGAHR MGGRACVFGE LVLAQQADVF 51DAAHGAAGAV AGKFLVAEHG QPFLQRKLEP VAAGYAVARP VVEILVSDHG 101 FDAFEIGIGGGAAVGKDELG VKDVQTLVFH RAHIEIAHGD DHENIQVVFQ 151 TEARFVPFHR VFXTIPRQSRPWACPLRWCK TRF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m664/g664 91.8% identity in 183 aa overlap        10        20        30        40        50        60 m664.pepVIHPHYFRAFFINGHGVEIVHLLIAGGAHRMGGRACVFGELVLAQQADVFDAAHGAAGAV:||||:||||||||||||||||||| |||||||||||||||||||||||:|||||||||| g664MIHPHHFRAFFINGHGVEIVHLLIADGAHRMGGRACVFGELVLAQQADVLDAAHGAAGAV        10        20        30        40        50        60        70        80        90       100       110       120 m664.pepAGKFLVAEHGQPFLQRKLEPVAAGYAVARPVVEILVSDHGFDAFEIGIGGGAAVGKDELG|||:||||||||||||||||||||||||||||||:||||||:|||||||||||||:|||| g664AGKLLVAEHGQPFLQRKLEPVAAGYAVARPVVEIFVSDHGFNAFEIGIGGGAAVGEDELG        70        80        90       100       110       120       130       140       150       160       170       180 m664.pepVKDVQTLVFHRAHIEIAHGDDHENIQVVFQTEARFVPFHRVFXTIPRQSRPWACPLRWCK||:||||||||||||||:|||||||||:|| ||||||:|||| |||||||||:||||||| g664VKNVQTLVFHRAHIEIAYGDDHENIQVIFQPEARFVPLHRVFSTIPRQSRPWVCPLRWCK       130       140       150       160       170       180 m664.pepTRFX |||| g664 TRFXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2157>:

a664.seq. 1 GTGATACATC CGCACCACTT CCGCGCCTTT TTCATAAACG GTCATGGTGT 51AGAAATTGTT CATCTCCTCA TATCGGGCGG GGCGCACCGG ATGTGCGGTC 101 GGACCTGCGTCTTCGGGGAA CTGGTGCTGG CGCAGCAGGC GGATGTTTTC 151 GATACGGCGC ACGGCGCGGCTGGCGCGGTC GCCGGAAAAT TCTTGGTCGC 201 GGAACACGGT CAACCCTTCC TTCAGCGAAAGCTGGAACCA GTCGCGGCAG 251 GTCACGCGGT TGCCCGTCCA GTTGTGGAAA TATTCGTGTCCGACCACGGA 301 TTCGATGCCT TCAAAATCGG TATCGGTGGC GGTACGGCTG TCGGCAAGGA351 CGAACTTGGT GTTAAAGATG TTCAAACCCT TGTTTTCCAT CGCACCCATA 401TTGAAATCGC CCACGGCGAC GACCATGAAA ATATCCAAGT CGTATTCCAA 451 ACCGAAGCGCGTTTCGTCCC ACTTCATTGC GTTTTT.CAG CGATTCCACG 501 GCAAAGCCGA CCTTGGGCTTGTCCGCTTCG GTGGTGTAAA ACTCGATTTT 551 GAThis corresponds to the amino acid sequence <SEQ ID 2158; ORF 664.a>:

a664.pep 1 VIHPHHFRAF FINGHGVEIV HLLISGGAHR MCGRTCVFGE LVLAQQADVF 51DTAHGAAGAV AGKFLVAEHG QPFLQRKLEP VAAGHAVARP VVEIFVSDHG 101 FDAFKIGIGGGTAVGKDELG VKDVQTLVFH RTHIEIAHGD DHENIQVVFQ 151 TEARFVPLHC VFXAIPRQSRPWACPLRWCK TRF* m664/a664 92.9% identity in 183 aa overlap        10        20        30        40        50        60 m664.pepVIHPHYFRAFFINGHGVEIVHLLIAGGAHRMGGRACVFGELVLAQQADVFDAAHGAAGAV|||||:||||||||||||||||||:|||||| ||:||||||||||||||||:|||||||| a664VIHPHHFRAFFINGHGVEIVHLLISGGAHRMCGRTCVFGELVLAQQADVFDTAHGAAGAV        10        20        30        40        50        60        70        80        90       100       110       120 m664.pepAGKFLVAEHGQPFLQRKLEPVAAGYAVARPVVEILVSDHGFDAFEIGIGGGAAVGKDELG||||||||||||||||||||||||:|||||||||:|||||||||:||||||:|||||||| a664AGKFLVAEHGQPFLQRKLEPVAAGHAVARPVVEIFVSDHGFDAFKIGIGGGTAVGKDELG        70        80        90       100       110       120       130       140       150       160       170       180 m664.pepVKDVQTLVFHRAHIEIAHGDDHENIQVVFQTEARFVPFHRVFXTIPRQSRPWACPLRWCK|||||||||||:|||||||||||||||||||||||||:| |||:|||||||||||||||| a664VKDVQTLVFHRTHIEIAHGDDHENIQVVFQTEARFVPLHCVFXAIPRQSRPWACPLRWCK       130       140       150       160       170       180 m664.pepTRFX |||| a664 TRFXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2159>:

g665.seq 1 atgaagtgGg acgaaacgcg cttcgGgttg GAAtatgact tggatatttT 51CATGGTCGTC GCCGTAGGCG ATTTCAATAT GGGCGCGATG GAAAACAAGG 101 GTTTGAACATTTTTAACACC AAGTTCGTCC TCGCCGACAG CCGCACCGCC 151 ACCGATACCG ATTTCGAAGGCATTGAATCC GTGGTCGGAC ACGAATATTT 201 CCACAACTGG ACGGGCAACC GCGTAACCTGCCGCGACTGG TTCCAGCTTT 251 CGCTGAAGGA AGGGCTGACC GTGTTCCGCG ACCAAGAGTTTTCCGGCGAC 301 CGCGCCGGCC GCGCCGTGCG CCGCATCGAG AACATCCGCC TGCTGCGCCA351 GAACCAGTTC CCCGAAGACG CAGGCCCGAC CGCCCATCCG GTGCGCcccg 401TCAGCTATGA GGAGATGAAC AATTTCTACA CCATGACCGT TTATGAAAAA 451 GGCGCGGAAGTGGTGCGGAT GTATCATACC CTGCTCGGCG AAGAGGGCTT 501 CCAAAAAGGC ATGAAGCTATATTTCcaacg CCACGACGGA CAGGCAGTGA 551 CCTGCGACGA TTTCCGCGCG GCGatggcggATGCGAACGG CATCAATCTC 601 GACCAGTTCG CCTTGTGGTA CAGCCAGGCG GGCACGCCCGTTTTGGAAGC 651 CGAAGGCCGT CTGAAAAACA ATGTTTTCGA GTTAACCATT AAACAAACCG701 TGCCGCCCAC GCCCGATATG GCGGACAAAC AGCCGATGAT GATTCCCGTC 751AAAGTCGGGC TTCTGAACCG CAACGGCGAA GCGGTGGCAT TCGATTATCA 801 GGGCAAACGCGCAACCGAAG CCGTGTTGCT GATGACCGAA GCCGAACagg 851 CCTTCCCGCT CGAAGGTGTAACCGAAGCCG TCGTTCCCTC GCTGCTGCGC 901 GGGTTCAGCG CGCCAGTGTA TCTGAACTATCCGTACAGCG ACGACGACCT 951 GCTGCTCCTG CTCGCCCACG ACAGCGACGC TTTCACGTGCTGGGAAGCCG 1001 CCCAAACGCT CTACCGTCGC GCCGTCGCCG CCAACCTTGC CGCGCTTTCA1051 GACGGCATCG GGTTGCCGAA ACACGAAAAA CTGCTTGCCG CCGTCGAAAA 1101AGTCATTTCA GACGACCTCT TGGACAACGC CTTCAAAGCC CTGCTTTTGG 1151 GCGTGCCGTCCGAAGCCGAa ctGTGGGACG GCACGGAAAA CATcgaCCCG 1201 CTGCGCTACC ATCAGGCGCGCGAAGCCTTG TTGGATACGC TTGCCGtcCG 1251 CttcctgcCG AAATGGCACG AATTGGaccgtcaggcggcg aagCAggaaa 1301 accaaagtTA CGAATACAGC CCCGAAACCG CCGACTGGCGCACGCTGCGC 1351 AACGTCTGCC GCGCCTtcgt cctGCGCGCC GACCCCGCGC acatcgAAAC1401 TGTTGCCGAA Aaatacggcg AAATGGCGCA AAACATGACC CACGAATGGG 1451GCATCCTGTC CGCCGTCAAC GGCAACGAAA GCGATACGCG CAACTGCCTG 1501 CTGGCGCAGTTTGCCGAcaa gTtttcAGAC GACGCGCTGG TGATGGACAA 1551 ATATTTCGCC CTTATCGGCTCAAGccgccg cagCGACACC CTGCAACAGG 1601 TTCAAACCGC CTTGCAGCAT CCGAAATTCAGTCTCGAAAA CCCCAACAAA 1651 GCCCGTTCGC TCATCGGCAG CTTCAGCCGC AACGTCCCGCATTTTCACGC 1701 ACAAGACGGC AGCGGCTACC GCTTCATCGC CGACAAAGTC ATCGAAATCG1751 ACCGCTTCAA cCCGCAggtc gccGCCCGCC TGGTGCAGGC GTTCAACCTC 1801TGCAACAAGC TCGAGCCGCA CCGCAAAAAC TTgGTGAAAC AAGAATTGCA 1851 GTGCATTCGGGCGCAGGAAG GATTGTCGAA AGacGTGGGC GAaatcgtCG 1901 GCAAGATTTT GGGTTGAThis corresponds to the amino acid sequence <SEQ ID 2160; ORF 665.ng>:

g665.pep 1 MKWDETRFGL EYDLDIFMVV AVGDFNMGAM ENKGLNIFNT KFVLADSRTA 51TDTDFEGIES VVGHEYFHNW TGNRVTCRDW FQLSLKEGLT VFRDQEFSGD 101 RAGRAVRRIENIRLLRQNQF PEDAGPTAHP VRPVSYEEMN NFYTMTVYEK 151 GAEVVRMYHT LLGEEGFQKGMKLYFQRHDG QAVTCDDFRA AMADANGINL 201 DQFALWYSQA GTPVLEAEGR LKNNVFELTIKQTVPPTPDM ADKQPMMIPV 251 KVGLLNRNGE AVAFDYQGKR ATEAVLLMTE AEQAFPLEGVTEAVVPSLLR 301 GFSAPVYLNY PYSDDDLLLL LAHDSDAFTC WEAAQTLYRR AVAANLAALS351 DGIGLPKHEK LLAAVEKVIS DDLLDNAFKA LLLGVPSEAE LWDGTENIDP 401LRYHQAREAL LDTLAVRFLP KWHELDRQAA KQENQSYEYS PETADWRTLR 451 NVCRAFVLRADPAHIETVAE KYGEMAQNMT HEWGILSAVN GNESDTRNCL 501 LAQFADKFSD DALVMDKYFALIGSSRRSDT LQQVQTALQH PKFSLENPNK 551 ARSLIGSFSR NVPHFHAQDG SGYRFIADKVIEIDRFNPQV AARLVQAFNL 601 CNKLEPHRKN LVKQELQCIR AQEGLSKDVG EIVGKILG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2161>:

m665.seq 1 ATGAAATGGG ACGAAACGCG CTTCGGTTTG GAATACGACT TGGATATTTT 51CATGGTCGTC GCCGTGGGCG ATTTCAATAT GGGCGCGATG GAAAACAAGG 101 GTTTGAACATCTTTAACACC AAGTTCGTCC TTGCCGACAG CCGCACCGCC 151 ACCGATACCG ATTTCGAAGGCATCGAATCC GTGGTCGGAC ACGAGTATTT 201 CCACAACTGG ACGGGCAACC GCGTAACCTGCCGCGACTGG TTCCAGCTTT 251 CGCTGAAGGA AGGGCTGACC GTGTTCCGCG ACCAAGAATTTTCCGGCGAC 301 CGCGCCAGCC GCGCCGTGCG CCGCATCGAA AACATCCGCC TGCTGCGCCA351 GCACCAGTTC CCCGAAGACG CAGGCCCGAC CGCCCATCCG GTGCGCCCCG 401CCAGCTATGA GGAGATGAAC AATTTCTACA CCATGACCGT TTATGAAAAA 451 GGCGCGGAAGTAGTGCGGAT GTATCACACC CTGCTCGGCG AAGAGGGCTT 501 CCAGAAAGGC ATGAAGCTCTATTTCCAACG CCACGACGGA CAGGCCGTTA 551 CCTGCGACGA TTTCCGCGCG GCGATGGCGGACGCGAACGG CATCAATCTC 601 GACCAGTTCG CCTTGTGGTA CAGCCAGGCG GGCACGCCCGTTTTGGAAGC 651 GGAAGGTCGT CTGAAAAACA ATATTTTCGA GTTGACCGTC AAACAAACCG701 TGCCGCCCAC GCCCGATATG ACGGATAAAC AGCCGATGAT GATTCCCGTC 751AAGGTCGGGC TGCTGAACCG CAACGGCGAA GCGGTGGCAT TCGACTATCA 801 GGGCAAACGCGCGACCGAAG CCGTGTTGCT GCTGACCGAA GCCGAACAGA 851 CCTTCCTGCT CGAAGGCGTAACCGAAGCCG TCGTTCCCTC GCTGCTGCGC 901 GGGTTCAGCG CGCCGGTGCA TCTGAACTATCCGTACAGCG ACGACGACCT 951 GCTGCTCCTG CTCGCCCATG ACAGCGACGC CTTCACGCGCTGGGAAGCCG 1001 CCCAAACGCT CTACCGCCGC GCCGTCGCCG CCAACCTTGC CACGCTTTCA1051 GACGGCGTTG AGCTGCCGAA ACACGAAAAA CTGCTTGCCG CCGTCGAAAA 1101AGTCATTTCA GACGACCTCT TAGACAACGC CTTCAAAGCC CTGCTTTTGG 1151 GCGTGCCATCCGAAGCCGAG CTGTGGGACG GCGCAGAAAA CATCGACCCG 1201 CTGCGCTACC ATCAGGCGCGCGAAGCCTTG TTGGATACGC TTGCCGTCCA 1251 CTTCCTGCCG AAATGGCACG AATTGAACCGTCAGGCGGCG AAGCAGGAAA 1301 ACCAAAGCTA CGAATACAGC CCCGAAGCCG CCGGCTGGCGCACGCTGCGC 1351 AACGTCTGCC GCGCCTTTGT CCTGCGCGCC GACCCCGCGC ACATCGAAAC1401 CGTTGCCGAA AAATACGGCG AAATGGCGCA AAACATGACC CACGAATGGG 1451GCATCCTGTC CGCCGTCAAC GGCAACGAAA GCGATACGCG CAACCGCCTG 1501 CTGGCGCAGTTTGCCGACAA GTTTTCAGAC GACGCGCTGG TGATGGACAA 1551 ATATTTTGCC CTCGTCGGCTCAAGCCGCCG CAGCGACACC CTGCAACAGG 1601 TTCGAACCGC CTTGCAGCAT CCGAAATTCAGCCTCGAAAA CCCCAACAAA 1651 GCCCGTTCGC TCATCGGCAG CTTCAGCCGC AACGTCCCGCATTTCCACGC 1701 AGAAGACGGC AGCGGCTACC GCTTCATCGC CGACAAAGTC ATCGAAATCG1751 ACCGCTTCAA CCCGCAGGTC GCCGCCCGCT TAGTGCAGGC GTTCAACCTC 1801TGCAACAAGC TCGAGCCGCA CCGCAAAAAC TTGGTGAAAC AAGCATTGCA 1851 GCGCATTCGGGCGCAGGAAG GATTGTCGAA AGACGTGGGC GAAATCGTCG 1901 GCAAAATTTT GGATTGAThis corresponds to the amino acid sequence <SEQ ID 2162; ORF 665>:

m665.pep 1 MKWDETRFGL EYDLDIFMVV AVGDFNMGAM ENKGLNIFNT KFVLADSRTA 51TDTDFEGIES VVGHEYFHNW TGNRVTCRDW FQLSLKEGLT VFRDQEFSGD 101 RASRAVRRIENIRLLRQHQF PEDAGPTAHP VRPASYEEMN NFYTMTVYEK 151 GAEVVRMYHT LLGEEGFQKGMKLYFQRHDG QAVTCDDFRA AMADANGINL 201 DQFALWYSQA GTPVLEAEGR LKNNIFELTVKQTVPPTPDM TDKQPMMIPV 251 KVGLLNRNGE AVAFDYQGKR ATEAVLLLTE AEQTFLLEGVTEAVVPSLLR 301 GFSAPVHLNY PYSDDDLLLL LAHDSDAFTR WEAAQTLYRR AVAANLATLS351 DGVELPKHEK LLAAVEKVIS DDLLDNAFKA LLLGVPSEAE LWDGAENIDP 401LRYHQAREAL LDTLAVHFLP KWHELNRQAA KQENQSYEYS PEAAGWRTLR 451 NVCRAFVLRADPAHIETVAE KYGEMAQNMT HEWGILSAVN GNESDTRNRL 501 LAQFADKFSD DALVMDKYFALVGSSRRSDT LQQVRTALQH PKFSLENPNK 551 ARSLIGSFSR NVPHFHAEDG SGYRFIADKVIEIDRFNPQV AARLVQAFNL 601 CNKLEPHRKN LVKQALQRIR AQEGLSKDVG EIVGKILD*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m665/g665 96.1% identity in 637 aa overlap        10        20        30        40        50        60 m665.pepMKWDETRFGLEYDLDIFMVVAVGDFNMGAMENKGLNIFNTKFVLADSRTATDTDFEGIES|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g665MKWDETRFGLEYDLDIFMVVAVGDFNMGAMENKGLNIFNTKFVLADSRTATDTDFEGIES        10        20        30        40        50        60        70        80        90       100       110       120 m665.pepVVGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSGDRASRAVRRIENIRLLRQHQF||||||||||||||||||||||||||||||||||||||||||:||||||||||||||:|| g665VVGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSGDRAGRAVRRIENIRLLRQNQF        70        80        90       100       110       120       130       140       150       160       170       180 m665.pepPEDAGPTAHPVRPASYEEMNNFYTMTVYEKGAEVVRMYHTLLGEEGFQKGMKLYFQRHDG|||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||| g665PEDAGPTAHPVRPVSYEEMNNFYTMTVYEKGAEVVRMYHTLLGEEGFQKGMKLYFQRHDG       130       140       150       160       170       180       190       200       210       220       230       240 m665.pepQAVTCDDFRAAMADANGINLDQFALWYSQAGTPVLEAEGRLKNNIFELTVKQTVPPTPDM||||||||||||||||||||||||||||||||||||||||||||:||||:|||||||||| g665QAVTCDDFRAAMADANGINLDQFALWYSQAGTPVLEAEGRLKNNVFELTIKQTVPPTPDM       190       200       210       220       230       240       250       260       270       280       290       300 m665.pepTDKQPMMIPVKVGLLNRNGEAVAFDYQGKRATEAVLLLTEAEQTFLLEGVTEAVVPSLLR:||||||||||||||||||||||||||||||||||||:|||||:| |||||||||||||| g665ADKQPMMIPVKVGLLNRNGEAVAFDYQGKRATEAVLLMTEAEQAFPLEGVTEAVVPSLLR       250       260       270       280       290       300       310       320       330       340       350       360 m665.pepGFSAPVHLNYPYSDDDLLLLLAHDSDAFTRWEAAQTLYRRAVAANLATLSDGVELPKHEK||||||:|||||||||||||||||||||| |||||||||||||||||:||||: |||||| g665GFSAPVYLNYPYSDDDLLLLLAHDSDAFTCWEAAQTLYRRAVAANLAALSDGIGLPKHEK       310       320       330       340       350       360       370       380       390       400       410       420 m665.pepLLAAVEKVISDDLLDNAFKALLLGVPSEAELWDGAENIDPLRYHQAREALLDTLAVHFLP||||||||||||||||||||||||||||||||||:|||||||||||||||||||||:||| g665LLAAVEKVISDDLLDNAFKALLLGVPSEAELWDGTENIDPLRYHQAREALLDTLAVRFLP       370       380       390       400       410       420       430       440       450       460       470       480 m665.pepKWHELNRQAAKQENQSYEYSPEAAGWRTLRNVCRAFVLRADPAHIETVAEKYGEMAQNMT|||||:||||||||||||||||:| ||||||||||||||||||||||||||||||||||| g665KWHELDRQAAKQENQSYEYSPETADWRTLRNVCRAFVLRADPAHIETVAEKYGEMAQNMT       430       440       450       460       470       480       490       500       510       520       530       540 m665.pepHEWGILSAVNGNESDTRNRLLAQFADKFSDDALVMDKYFALVGSSRRSDTLQQVRTALQH|||||||||||||||||| ||||||||||||||||||||||:||||||||||||:||||| g665HEWGILSAVNGNESDTRNCLLAQFADKFSDDALVMDKYFALIGSSRRSDTLQQVQTALQH       490       500       510       520       530       540       550       560       570       580       590       600 m665.pepPKFSLENPNKARSLIGSFSRNVPHFHAEDGSGYRFIADKVIEIDRFNPQVAARLVQAFNL|||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||| g665PKFSLENPNKARSLIGSFSRNVPHFHAQDGSGYRFIADKVIEIDRFNPQVAARLVQAFNL       550       560       570       580       590       600       610       620       630       639 m665.pepCNKLEPHRKNLVKQALQRIRAQEGLSKDVGEIVGKILDX|||||||||||||| || ||||||||||||||||||| g665CNKLEPHRKNLVKQELQCIRAQEGLSKDVGEIVGKILGX        610       620       630The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2163>:

a665.seq 1 ATGAAGTGGG ACGAAACGCG CTTCGGTTTG GAATACGACT TGGATATTTT 51CATGGTCGTC GCCGTGGGCG ATTTCAATAT GGGTGCGATG GAAAACAAGG 101 GTTTGAACATCTTTAACACC AAGTTCGTCC TTGCCGACAG CCGTACCGCC 151 ACCGATACCG ATTTTGAAGGCATCGAATCC GTGGTCGGAC ACGAATATTT 201 CCACAACTGG ACGGGCAACC GCGTGACCTGCCGCGACTGG TTCCAGCTTT 251 CGCTGAAGGA AGGGTTGACC GTGTTCCGCG ACCAAGAATTTTCCGGCGAC 301 CGCGCCAGCC GCGCCGTGCG CCGTATCGAA AACATCCGCC TGCTGCGCCA351 GCACCAGTTC CCCGAAGACG CAGGTCCGAC CGCACATCCG GTGCGCCCCG 401CCCGATATGA GGAGATGAAC AATTTCTACA CCATGACCGT TTATGAAAAA 451 GGCGCGGAAGTGGTGCGGAT GTATCACACC TTGCTCGGCG AAGAGGGCTT 501 CCAAAAAGGT ATGAAGCTCTATTTCCAACG CCACGACGGA CAGGCTGTTA 551 CCTGCGACGA TTTCCGCGCG GCGATGGTGGACGCGAACGG CATCAACCTC 601 GACCAATTCG CCTTGTGGTA CAGCCAAGCA GGTACGCCGGTTTTAGATGC 651 TCAAGGGCGT CTGAAAAACA ATGTGTTCGA GTTAACCATC AAACAAACCG701 TGCCGCCCAC GCCCGATATG GCGGACAAAC AGCCGATGAT GATTCCCGTC 751AAAATCGGGC TGCTGAACTG CAACGGCGAA GCGGTGGCAT TTGATTATCA 801 GGGCAAACGCGCGACCGAAG CCGTGTTGCT GCTGACCGAA GCCGAACAGA 851 CCTTCCAGTT CGAAAGCGTAACCGAAGCCG TCGTTCCCTC GCTGCTGCGC 901 GGGTTCAGCG CGCCGGTGCA TCTGAACTATCCGTACAGCG ACGACGACCT 951 GCTGCTTCTG CTCGCCCATG ACAGCGACGC CTTCACGCGCTGGGAAGCCG 1001 CACAAACGCT CTACCGCCGT GCCGTCGCCG CCAACCTTGC CGCGCTTTCA1051 GACGGCGTCG AGTTGCCGAA ACACGAAAAA CTGCTTGCCG CCGTCGAAAA 1101AGTCATTTCA GACGACCTCT TAGACAACGC TTTCAAAGCC CTGCTTTTGG 1151 GTGTGCCGTCTGAAGCCGAG CTGTGGGACG GCGCGGAAAA CATCGACCCG 1201 CTGCGCTACC ATCAGGCGCGCGAAGCCTTG TTGGATATAC TTGCCGTCCG 1251 CTTTCTGCCG AAATGGCACG AATTGAACCGTCAGGCGGCG AAGCAGGAAA 1301 ACCAAAGCTA CGAGTACAGC CCCGAAGCCG CCGGTTGGCGCACGCTGCGC 1351 AATGTCTGCC GCGCCTTCGT CCTGCGCGCC GATCCCGCGC ACATCGAAAC1401 CGTTGCCGAG AAATACGCCG AAATGGCGCA AAACATGACC CACGAATGGG 1451GCATCCTGTC CGCCGTCAAC GGCAACGAAA GCGATACGCG CAACCGCCTG 1501 CTGGCGCAGTTTGCCGACAA GTTTTCAGAC GACGCGCTGG TGATGGACAA 1551 ATATTTCGCC CTCGTCGGCTCAAGCCGCCG CAGCGACACC CTGCAACAGG 1601 TTCAAACCGC CTTGCAGCAT CCGAAGTTCAGCCTCGAAAA TCCCAACAAA 1651 GCCCGCTCGC TCATCGGCAG CTTCAGCCGC AACGTCCCGCATTTCCACGC 1701 AGAAGACGGC AGCGGCTACC GCTTCATCGC CGACAAAGTC ATCGAAATCG1751 ACCGCTTTAA CCCGCAGGTC GCCGCCCGCC TGGTGCAGGC GTTCAACCTC 1801TGCAACAAGC TCGAGCCGCA CCGCAAAAAC TTGGTGAAAC AAGCATTGCA 1851 GCGCATTCGGGCGCAGGAAG GATTGTCGAA AGACGTGGGC GAAATCGTCG 1901 GCAAAATTTT GGATTGAThis corresponds to the amino acid sequence <SEQ ID 2164; ORF 665.a>:

a665.pep 1 MKWDETRFGL EYDLDIFMVV AVGDFNMGAM ENKGLNIFNT KFVLADSRTA 51TDTDFEGIES VVGHEYFHNW TGNRVTCRDW FQLSLKEGLT VFRDQEFSGD 101 RASRAVRRIENIRLLRQHQF PEDAGPTAHP VRPARYEEMN NFYTMTVYEK 151 GAEVVRMYHT LLGEEGFQKGMKLYFQRHDG QAVTCDDFRA AMVDANGINL 201 DQFALWYSQA GTPVLDAQGR LKNNVFELTIKQTVPPTPDM ADKQPMMIPV 251 KIGLLNCNGE AVAFDYQGKR ATEAVLLLTE AEQTFQFESVTEAVVPSLLR 301 GFSAPVHLNY PYSDDDLLLL LAHDSDAFTR WEAAQTLYRR AVAANLAALS351 DGVELPKHEK LLAAVEKVIS DDLLDNAFKA LLLGVPSEAE LWDGAENIDP 401LRYHQAREAL LDILAVRFLP KWHELNRQAA KQENQSYEYS PEAAGWRTLR 451 NVCRAFVLRADPAHIETVAE KYAEMAQNMT HEWGILSAVN GNESDTRNRL 501 LAQFADKFSD DALVMDKYFALVGSSRRSDT LQQVQTALQH PKFSLENPNK 551 ARSLIGSFSR NVPHFHAEDG SGYRFIADKVIEIDRFNPQV AARLVQAFNL 601 CNKLEPHRKN LVKQALQRIR AQEGLSKDVG EIVGKILD*m665/a665 97.3% identity in 638 aa overlap        10        20        30        40        50        60 m665.pepMKWDETRFGLEYDLDIFMVVAVGDFNMGAMENKGLNIFNTKFVLADSRTATDTDFEGIES|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a665MKWDETRFGLEYDLDIFMVVAVGDFNMGAMENKGLNIFNTKFVLADSRTATDTDFEGIES        10        20        30        40        50        60        70        80        90       100       110       120 m665.pepVVGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSGDRASRAVRRIENIRLLRQHQF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a665VVGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSGDRASRAVRRIENIRLLRQHQF        70        80        90       100       110       120       130       140       150       160       170       180 m665.pepPEDAGPTAHPVRPASYEEMNNFYTMTVYEKGAEVVRMYHTLLGEEGFQKGMKLYFQRHDG|||||||||||||| ||||||||||||||||||||||||||||||||||||||||||||| a665PEDAGPTAHPVRPARYEEMNNFYTMTVYEKGAEVVRMYHTLLGEEGFQKGMKLYFQRHDG       130       140       150       160       170       180       190       200       210       220       230       240 m665.pepQAVTCDDFRAAMADANGINLDQFALWYSQAGTPVLEAEGRLKNNIFELTVKQTVPPTPDM||||||||||||:||||||||||||||||||||||:|:||||||:||||:|||||||||| a665QAVTCDDFRAAMVDANGINLDQFALWYSQAGTPVLDAQGRLKNNVFELTIKQTVPPTPDM       190       200       210       220       230       240       250       260       270       280       290       300 m665.pepTDKQPMMIPVKVGLLNRNGEAVAFDYQGKRATEAVLLLTEAEQTFLLEGVTEAVVPSLLR:||||||||||:|||| |||||||||||||||||||||||||||| :|:||||||||||| a665ADKQPMMIPVKIGLLNCNGEAVAFDYQGKRATEAVLLLTEAEQTFQFESVTEAVVPSLLR       250       260       270       280       290       300       310       320       330       340       350       360 m665.pepGFSAPVHLNYPYSDDDLLLLLAHDSDAFTRWEAAQTLYRRAVAANLATLSDGVELPKHEK|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||| a665GFSAPVHLNYPYSDDDLLLLLAHDSDAFTRWEAAQTLYRRAVAANLAALSDGVELPKHEK       310       320       330       340       350       360       370       380       390       400       410       420 m665.pepLLAAVEKVISDDLLDNAFKALLLGVPSEAELWDGAENIDPLRYHQAREALLDTLAVHFLP|||||||||||||||||||||||||||||||||||||||||||||||||||| |||:||| a665LLAAVEKVISDDLLDNAFKALLLGVPSEAELWDGAENIDPLRYHQAREALLDILAVRFLP       370       380       390       400       410       420       430       440       450       460       470       480 m665.pepKWHELNRQAAKQENQSYEYSPEAAGWRTLRNVCRAFVLRADPAHIETVAEKYGEMAQNMT||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||| a665KWHELNRQAAKQENQSYEYSPEAAGWRTLRNVCRAFVLRADPAHIETVAEKYAEMAQNMT       430       440       450       460       470       480       490       500       510       520       530       540 m665.pepHEWGILSAVNGNESDTRNRLLAQFADKFSDDALVMDKYFALVGSSRRSDTLQQVRTALQH||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| a665HEWGILSAVNGNESDTRNRLLAQFADKFSDDALVMDKYFALVGSSRRSDTLQQVQTALQH       490       500       510       520       530       540       550       560       570       580       590       600 m665.pepPKFSLENPNKARSLIGSFSRNVPHFHAEDGSGYRFIADKVIEIDRFNPQVAARLVQAFNL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a665PKFSLENPNKARSLIGSFSRNVPHFHAEDGSGYRFIADKVIEIDRFNPQVAARLVQAFNL       550       560       570       580       590       600       610       620       630      639 m665.pepCNKLEPHRKNLVKQALQRIRAQEGLSKDVGEIVGKILDX||||||||||||||||||||||||||||||||||||||| a665CNKLEPHRKNLVKQALQRIRAQEGLSKDVGEIVGKILDX        610       620       630The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2165>:

g665-1.seq 1 ATGAGCAAAA CCGTCCGTTA TCTGAAAGAT TACCAAACGC CTGCCTACCG 51CATTCTTGAA ACCGAACTGC ATTTCGACAT TGCCGAACCG CAAACCGTCG 101 TGAAGTCGCGTTTGACGGTC GAGCCGCAGA GGGCGGGCGA GCCGCTGGTG 151 TTGGACGGTT CGGCAAAACTCTTGTCCGTC AAAATCAACG GCGCGGCGGC 201 GGATTATGTG TTGGAAGGCG AGACGCTGACGATTGCAGAC GTACCGTCCG 251 AACGCTTCAC CGTCGAAGTG GAAACCGAAA TCCTGCCGGCGGAAAACAAA 301 TCGCTGATGG GGCTGTATGC TTCCGGCGGC AATCTGTTTA CCCAGTGCGA351 GCCGGAGGGC TTCCGCAAAA TCACGTTCTA CATCGACCGT CCGGATGTGA 401TGTCCAAGTT CACGACCACC ATCGTCGCGG ACAAAAAACG CTATCCCGTT 451 TTGCTTTCCAACGGCAACAA AATCGACGGC GGCGAGTTTT CAGACGGCCG 501 CCATTGGGTG AAATGGGAAGACCCGTTTGC CAAACCGAGT TATCTGTTTG 551 CTTTGGTCGC GGGCGATTTG GCGGTAACGGAAGACCGTTT CACCACCATG 601 AGCGGCAGAA ACGTCAAAAT CGAGTTTTAC ACCACCGAAGCGGACAAACC 651 CAAGGTCGGC TTTGCCGTGG AATCGTTGAA AAACGCGATG AAGTGGGACG701 AAACGCGCTT CGGGTTGGAA TATGACTTGG ATATTTTCAT GGTCGTCGCC 751GTAGGCGATT TCAATATGGG CGCGATGGAA AACAAGGGTT TGAACATTTT 801 TAACACCAAGTTCGTCCTCG CCGACAGCCG CACCGCCACC GATACCGATT 851 TCGAAGGCAT TGAATCCGTGGTCGGACACG AATATTTCCA CAACTGGACG 901 GGCAACCGCG TAACCTGCCG CGACTGGTTCCAGCTTTCGC TGAAGGAAGG 951 GCTGACCGTG TTCCGCGACC AAGAGTTTTC CGGCGACCGCGCCGGCCGCG 1001 CCGTGCGCCG CATCGAGAAC ATCCGCCTGC TGCGCCAGAA CCAGTTCCCC1051 GAAGACGCAG GCCCGACCGC CCATCCGGTG CGCCCCGTCA GCTATGAGGA 1101GATGAACAAT TTCTACACCA TGACCGTTTA TGAAAAAGGC GCGGAAGTGG 1151 TGCGGATGTATCATACCCTG CTCGGCGAAG AGGGCTTCCA AAAAGGCATG 1201 AAGCTATATT TCCAACGCCACGACGGACAG GCAGTGACCT GCGACGATTT 1251 CCGCGCGGCG ATGGCGGATG CGAACGGCATCAATCTCGAC CAGTTCGCCT 1301 TGTGGTACAG CCAGGCGGGC ACGCCCGTTT TGGAAGCCGAAGGCCGTCTG 1351 AAAAACAATG TTTTCGAGTT AACCATTAAA CAAACCGTGC CGCCCACGCC1401 CGATATGGCG GACAAACAGC CGATGATGAT TCCCGTCAAA GTCGGGCTTC 1451TGAACCGCAA CGGCGAAGCG GTGGCATTCG ATTATCAGGG CAAACGCGCA 1501 ACCGAAGCCGTGTTGCTGAT GACCGAAGCC GAACAGGCCT TCCCGCTCGA 1551 AGGTGTAACC GAAGCCGTCGTTCCCTCGCT GCTGCGCGGG TTCAGCGCGC 1601 CAGTGTATCT GAACTATCCG TACAGCGACGACGACCTGCT GCTCCTGCTC 1651 GCCCACGACA GCGACGCTTT CACGTGCTGG GAAGCCGCCCAAACGCTCTA 1701 CCGTCGCGCC GTCGCCGCCA ACCTTGCCGC GCTTTCAGAC GGCATCGGGT1751 TGCCGAAACA CGAAAAACTG CTTGCCGCCG TCGAAAAAGT CATTTCAGAC 1801GACCTCTTGG ACAACGCCTT CAAAGCCCTG CTTTTGGGCG TGCCGTCCGA 1851 AGCCGAACTGTGGGACGGCA CGGAAAACAT CGACCCGCTG CGCTACCATC 1901 AGGCGCGCGA AGCCTTGTTGGATACGCTTG CCGTCCGCTT CCTGCCGAAA 1951 TGGCACGAAT TGGACCGTCA GGCGGCGAAGCAGGAAAACC AAAGTTACGA 2001 ATACAGCCCC GAAACCGCCG ACTGGCGCAC GCTGCGCAACGTCTGCCGCG 2051 CCTTCGTCCT GCGCGCCGAC CCCGCGCACA TCGAAACTGT TGCCGAAAAA2101 TACGGCGAAA TGGCGCAAAA CATGACCCAC GAATGGGGCA TCCTGTCCGC 2151CGTCAACGGC AACGAAAGCG ATACGCGCAA CTGCCTGCTG GCGCAGTTTG 2201 CCGACAAGTTTTCAGACGAC GCGCTGGTGA TGGACAAATA TTTCGCCCTT 2251 ATCGGCTCAA GCCGCCGCAGCGACACCCTG CAACAGGTTC AAACCGCCTT 2301 GCAGCATCCG AAATTCAGTC TCGAAAACCCCAACAAAGCC CGTTCGCTCA 2351 TCGGCAGCTT CAGCCGCAAC GTCCCGCATT TTCACGCACAAGACGGCAGC 2401 GGCTACCGCT TCATCGCCGA CAAAGTCATC GAAATCGACC GCTTCAACCC2451 GCAGGTCGCC GCCCGCCTGG TGCAGGCGTT CAACCTCTGC AACAAGCTCG 2501AGCCGCACCG CAAAAACTTG GTGAAACAAG AATTGCAGTG CATTCGGGCG 2551 CAGGAAGGATTGTCGAAAGA CGTGGGCGAA ATCGTCGGCA AGATTTTGGG 2601 TTGAThis corresponds to the amino acid sequence <SEQ ID 2166; ORF 665-1.ng>:

g665-1.pep 1 MSKTVRYLKD YQTPAYRILE TELHFDIAEP QTVVKSRLTV EPQRAGEPLV 51LDGSAKLLSV KINGAAADYV LEGETLTIAD VPSERFTVEV ETEILPAENK 101 SLMGLYASGGNLFTQCEPEG FRKITFYIDR PDVMSKFTTT IVADKKRYPV 151 LLSNGNKIDG GEFSDGRHWVKWEDPFAKPS YLFALVAGDL AVTEDRFTTM 201 SGRNVKIEFY TTEADKPKVG FAVESLKNAMKWDETRFGLE YDLDIFMVVA 251 VGDFNMGAME NKGLNIFNTK FVLADSRTAT DTDFEGIESVVGHEYFHNWT 301 GNRVTCRDWF QLSLKEGLTV FRDQEFSGDR AGRAVRRIEN IRLLRQNQFP351 EDAGPTAHPV RPVSYEEMNN FYTMTVYEKG AEVVRMYHTL LGEEGFQKGM 401KLYFQRHDGQ AVTCDDFRAA MADANGINLD QFALWYSQAG TPVLEAEGRL 451 KNNVFELTIKQTVPPTPDMA DKQPMMIPVK VGLLNRNGEA VAFDYQGKRA 501 TEAVLLMTEA EQAFPLEGVTEAVVPSLLRG FSAPVYLNYP YSDDDLLLLL 551 AHDSDAFTCW EAAQTLYRRA VAANLAALSDGIGLPKHEKL LAAVEKVISD 601 DLLDNAFKAL LLGVPSEAEL WDGTENIDPL RYHQAREALLDTLAVRFLPK 651 WHELDRQAAK QENQSYEYSP ETADWRTLRN VCRAFVLRAD PAHIETVAEK701 YGEMAQNMTH EWGILSAVNG NESDTRNCLL AQFADKFSDD ALVMDKYFAL 751IGSSRRSDTL QQVQTALQHP KFSLENPNKA RSLIGSFSRN VPHFHAQDGS 801 GYRFIADKVIEIDRFNPQVA ARLVQAFNLC NKLEPHRKNL VKQELQCIRA 851 QEGLSKDVGE IVGKILG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2167>:

m665-1.seq 1 ATGAGCAAAA CCGTGCATTA TCTCAAAGAC TATCAAACGC CCGCCTACCA 51TATTCTCAAA ACCGATTTAC ATTTTGATAT TAATGAACCG CAAACCGTCG 101 TGAAGTCGCGTTTGACGGTT GAGCCGCAGA GGGTAGGGGA GCCGCTGGTG 151 TTGGACGGTT CGGCGAAACTCTTGTCCGTC AAAATCAACG GGGCGGCGGC 201 GGATTATGTG TTGGAAGGAG AGACGCTGACGATTGCGGGC GTGCCGTCCG 251 AACGCTTCAC CGTCGAAGTG GAAACCGAAA TCCTGCCGGCGGAAAACAAA 301 TCGCTGATGG GGCTGTATGC TTCCGGCGGC AATTTGTTTA CCCAGTGCGA351 GCCGGAGGGC TTCCGCAAAA TCACATTTTA CATCGACCGT CCGGATGTGA 401TGTCCAAGTT CACCACCACC ATCGTCGCCG ACAAAAAACG CTATCCCGTT 451 TTGCTTTCCAACGGCAACAA AATCGACGGC GGCGAGTTTT CAGACGGCCG 501 CCATTGGGTG AAATGGGAAGACCCGTTTTC CAAACCGAGC TATCTGTTTG 551 CTTTGGTCGC GGGCGATTTG GCGGTAACGGAAGACTATTT CACCACCATG 601 AGCGGCAGAA ACGTCAAAAT CGAGTTTTAC ACCACCGAAGCGGACAAGCC 651 CAAGGTCGGC TTTGCCGTGG AATCGTTGAA AAACGCGATG AAATGGGACG701 AAACGCGCTT CGGTTTGGAA TACGACTTGG ATATTTTCAT GGTCGTCGCC 751GTGGGCGATT TCAATATGGG CGCGATGGAA AACAAGGGTT TGAACATCTT 801 TAACACCAAGTTCGTCCTTG CCGACAGCCG CACCGCCACC GATACCGATT 851 TCGAAGGCAT CGAATCCGTGGTCGGACACG AGTATTTCCA CAACTGGACG 901 GGCAACCGCG TAACCTGCCG CGACTGGTTCCAGCTTTCGC TGAAGGAAGG 951 GCTGACCGTG TTCCGCGACC AAGAATTTTC CGGCGACCGCGCCAGCCGCG 1001 CCGTGCGCCG CATCGAAAAC ATCCGCCTGC TGCGCCAGCA CCAGTTCCCC1051 GAAGACGCAG GCCCGACCGC CCATCCGGTG CGCCCCGCCA GCTATGAGGA 1101GATGAACAAT TTCTACACCA TGACCGTTTA TGAAAAAGGC GCGGAAGTAG 1151 TGCGGATGTATCACACCCTG CTCGGCGAAG AGGGCTTCCA GAAAGGCATG 1201 AAGCTCTATT TCCAACGCCACGACGGACAG GCCGTTACCT GCGACGATTT 1251 CCGCGCGGCG ATGGCGGACG CGAACGGCATCAATCTCGAC CAGTTCGCCT 1301 TGTGGTACAG CCAGGCGGGC ACGCCCGTTT TGGAAGCGGAAGGTCGTCTG 1351 AAAAACAATA TTTTCGAGTT GACCGTCAAA CAAACCGTGC CGCCCACGCC1401 CGATATGACG GATAAACAGC CGATGATGAT TCCCGTCAAG GTCGGGCTGC 1451TGAACCGCAA CGGCGAAGCG GTGGCATTCG ACTATCAGGG CAAACGCGCG 1501 ACCGAAGCCGTGTTGCTGCT GACCGAAGCC GAACAGACCT TCCTGCTCGA 1551 AGGCGTAACC GAAGCCGTCGTTCCCTCGCT GCTGCGCGGG TTCAGCGCGC 1601 CGGTGCATCT GAACTATCCG TACAGCGACGACGACCTGCT GCTCCTGCTC 1651 GCCCATGACA GCGACGCCTT CACGCGCTGG GAAGCCGCCCAAACGCTCTA 1701 CCGCCGCGCC GTCGCCGCCA ACCTTGCCAC GCTTTCAGAC GGCGTTGAGC1751 TGCCGAAACA CGAAAAACTG CTTGCCGCCG TCGAAAAAGT CATTTCAGAC 1801GACCTCTTAG ACAACGCCTT CAAAGCCCTG CTTTTGGGCG TGCCATCCGA 1851 AGCCGAGCTGTGGGACGGCG CAGAAAACAT CGACCCGCTG CGCTACCATC 1901 AGGCGCGCGA AGCCTTGTTGGATACGCTTG CCGTCCACTT CCTGCCGAAA 1951 TGGCACGAAT TGAACCGTCA GGCGGCGAAGCAGGAAAACC AAAGCTACGA 2001 ATACAGCCCC GAAGCCGCCG GCTGGCGCAC GCTGCGCAACGTCTGCCGCG 2051 CCTTTGTCCT GCGCGCCGAC CCCGCGCACA TCGAAACCGT TGCCGAAAAA2101 TACGGCGAAA TGGCGCAAAA CATGACCCAC GAATGGGGCA TCCTGTCCGC 2151CGTCAACGGC AACGAAAGCG ATACGCGCAA CCGCCTGCTG GCGCAGTTTG 2201 CCGACAAGTTTTCAGACGAC GCGCTGGTGA TGGACAAATA TTTTGCCCTC 2251 GTCGGCTCAA GCCGCCGCAGCGACACCCTG CAACAGGTTC GAACCGCCTT 2301 GCAGCATCCG AAATTCAGCC TCGAAAACCCCAACAAAGCC CGTTCGCTCA 2351 TCGGCAGCTT CAGCCGCAAC GTCCCGCATT TCCACGCAGAAGACGGCAGC 2401 GGCTACCGCT TCATCGCCGA CAAAGTCATC GAAATCGACC GCTTCAACCC2451 GCAGGTCGCC GCCCGCTTAG TGCAGGCGTT CAACCTCTGC AACAAGCTCG 2501AGCCGCACCG CAAAAACTTG GTGAAACAAG CATTGCAGCG CATTCGGGCG 2551 CAGGAAGGATTGTCGAAAGA CGTGGGCGAA ATCGTCGGCA AAATTTTGGA 2601 TTGAThis corresponds to the amino acid sequence <SEQ ID 2168; ORF 665-1>:

m665-1.pep 1 MSKTVHYLKD YQTPAYHILK TDLHFDINEP QTVVKSRLTV EPQRVGEPLV 51LDGSAKLLSV KINGAAADYV LEGETLTIAG VPSERFTVEV ETEILPAENK 101 SLMGLYASGGNLFTQCEPEG FRKITFYIDR PDVMSKFTTT IVADKKRYPV 151 LLSNGNKIDG GEFSDGRHWVKWEDPFSKPS YLFALVAGDL AVTEDYFTTM 201 SGRNVKIEFY TTEADKPKVG FAVESLKNAMKWDETRFGLE YDLDIFMVVA 251 VGDFNMGAME NKGLNIFNTK FVLADSRTAT DTDFEGIESVVGHEYFHNWT 301 GNRVTCRDWF QLSLKEGLTV FRDQEFSGDR ASRAVRRIEN IRLLRQHQFP351 EDAGPTAHPV RPASYEEMNN FYTMTVYEKG AEVVRMYHTL LGEEGFQKGM 401KLYFQRHDGQ AVTCDDFRAA MADANGINLD QFALWYSQAG TPVLEAEGRL 451 KNNIFELTVKQTVPPTPDMT DKQPMMIPVK VGLLNRNGEA VAFDYQGKRA 501 TEAVLLLTEA EQTFLLEGVTEAVVPSLLRG FSAPVHLNYP YSDDDLLLLL 551 AHDSDAFTRW EAAQTLYRRA VAANLATLSDGVELPKHEKL LAAVEKVISD 601 DLLDNAFKAL LLGVPSEAEL WDGAENIDPL RYHQAREALLDTLAVHFLPK 651 WHELNRQAAK QENQSYEYSP EAAGWRTLRN VCRAFVLRAD PAHIETVAEK701 YGEMAQNMTH EWGILSAVNG NESDTRNRLL AQFADKFSDD ALVMDKYFAL 751VGSSRRSDTL QQVRTALQHP KFSLENPNKA RSLIGSFSRN VPHFHAEDGS 801 GYRFIADKVIEIDRFNPQVA ARLVQAFNLC NKLEPHRKNL VKQALQRIRA 851 QEGLSKDVGE IVGKILD*m665-1/g665-1 96.1% identity in 866 aa overlap        10        20        30        40        50        60 m665-1.pepMSKTVHYLKDYQTPAYHILKTDLHFDINEPQTVVKSRLTVEPQRVGEPLVLDGSAKLLSV|||||:||||||||||:||:|:||||| ||||||||||||||||:||||||||||||||| g665-1MSKTVRYLKDYQTPAYRILETELHFDIAEPQTVVKSRLTVEPQRAGEPLVLDGSAKLLSV        10        20        30        40        50        60        70        80        90       100       110       120 m665-1.pepKINGAAADYVLEGELLTIAGVPSERFTVEVETEILPAENKSLMGLYASGGNLFTQCEPEG||||||||||||||||||| |||||||||||||||||||||||||||||||||||||||| g665-1KINGAAADYVLEGELLTIADVPSERFTVEVETEILPAENKSLMGLYASGGNLFTQCEPEG        70        80        90       100       110       120       130       140       150       160       170       180 m665-1.pepFRKITFYIDRPDVMSKFTTTIVADKKRYPVLLSNGNKIDGGEFSDGRHWVKWEDPFSKPS||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||| g665-1FRKITFYIDRPDVMSKFTTTIVADKKRYPVLLSNGNKIDGGEFSDGRHWVKWEDPFAKPS       130       140       150       160       170       180       190       200       210       220       230       240 m665-1.pepYLFALVAGDLAVTEDYFTTMSGRNVKIEFYTTEADKPKVGFAVESLKNAMKWDETRFGLE||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| g665-1YLFALVAGDLAVTEDRFTTMSGRNVKIEFYTTEADKPKVGFAVESLKNAMKWDETRFGLE       190       200       210       220       230       240       250       260       270       280       290       300 m665-1.pepYDLDIFMVVAVGDFNMGAMENKGLNIFNTKFVLADSRTATDTDFEGIESVVGHEYFHNWT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g665-1YDLDIFMVVAVGDFNMGAMENKGLNIFNTKFVLADSRTATDTDFEGIESVVGHEYFHNWT       250       260       270       280       290       300       310       320       330       340       350       360 m665-1.pepGNRVTCRDWFQLSLKEGLTVERDQEFSGDRASRAVRRIENIRLLRQHQFPEDAGPTAHPV|||||||||||||||||||||||||||||||:||||||||||||||:||||||||||||| g665-1GNRVTCRDWFQLSLKEGLTVERDQEFSGDRAGRAVRRIENIRLLRQNQFPEDAGPTAHPV       310       320       330       340       350       360       370       380       390       400       410       420 m665-1.pepRPASYEEMNITFYTMTVYEKGAEVVRMYHTLLGEEGFQKGMKLYFQRHDGQAVTCDDFRAA||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g665-1RPVSYEEMNITFYTMTVYEKGAEVVRMYHTLLGEEGFQKGMKLYFQRHDGQAVTCDDFRAA       370       380       390       400       410       420       430       440       450       460       470       480 m665-1.pepMADANGINLDQFALWYSQAGTPVLEAEGRLKNNIFELTVKQTVPPTPDMTDKQPMMIPVK|||||||||||||||||||||||||||||||||:||||:||||||||||:|||||||||| g665-1MADANGINLDQFALWYSQAGTPVLEAEGRLKNNVFELTIKQTVPPTPDMADKQPMMIPVK       430       440       450       460       470       480       490       500       510       520       530       540 m665-1.pepVGLLNRNGEAVAFDYQGKRATEAVLLLTEAEQTFLLEGVTEAVVPSLLRGFSAPVHLNYP||||||||||||||||||||||||||:|||||:| ||||||||||||||||||||:|||| g665-1VGLLNRNGEAVAFDYQGKRATEAVLLMTEAEQAFPLEGVTEAVVPSLLRGFSAPVYLNYP       490       500       510       520       530       540       550       560       570       580       590       600 m665-1.pepYSDDDLLLLLAHDSDAFTRWEAAQTLYRRAVAANLATLSDGVELPKHEKLLAAVEKVISD|||||||||||||||||| |||||||||||||||||:||||: ||||||||||||||||| g665-1YSDDDLLLLLAHDSDAFTCWEAAQTLYRRAVAANLAALSDGIGLPKHEKLLAAVEKVISD       550       560       570       580       590       600       610       620       630       640       650       660 m665-1.pepDLLDNAFKALLLGVPSEAELWDGAENIDPLRYHQAREALLDTLAVHFLPKWHELNRQAAK|||||||||||||||||||||||:|||||||||||||||||||||:||||||||:||||| g665-1DLLDNAFKALLLGVPSEAELWDGTENIDPLRYHQAREALLDTLAVRFLPKWHELDRQAAK       610       620       630       640       650       660       670       680       690       700       710       720 m665-1.pepQENQSYEYSPEAAGWRTLRNVCRAFVLRADPAHIETVAEKYGEMAQNMTHEWGILSAVNG|||||||||||:| |||||||||||||||||||||||||||||||||||||||||||||| g665-1QENQSYEYSPETADWRTLRNVCRAFVLRADPAHIETVAEKYGEMAQNMTHEWGILSAVNG       670       680       690       700       710       720       730       740       750       760       770       780 m665-1.pepNESDTRNRLLAQFADKFSDDALVMDKYFALVGSSRRSDTLQQVRTALQHPKFSLENPNKA||||||| ||||||||||||||||||||||:||||||||||||:|||||||||||||||| g665-1NESDTRNCLLAQFADKFSDDALVMDKYFALIGSSRRSDTLQQVQTALQHPKFSLENPNKA       730       740       750       760       770       780       790       800       810       820       830       840 m665-1.pepRSLIGSFSRNVPHFHAEDGSGYRFIADKVIEIDRFNPQVAARLVQAFNLCNKLEPHRKNL||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||| g665-1RSLIGSFSRNVPHFHAQDGSGYRFIADKVIEIDRFNPQVAARLVQAFNLCNKLEPHRKNL       790       800       810       820       830       840       850       860 m665-1.pep VKQALQRIRAQEGLSKDVGEIVGKILDX||| || ||||||||||||||||||| g665-1 VKQELQCIRAQEGLSKDVGEIVGKILGX       850       860The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2169>:

a665-1.seq 1 ATGAGCAAAA CCGTGCATTA TCTCAAAGAC TATCAAACGC CCGCCTACCA 51TATTCTCAAA ACCGATTTAC ATTTTGATAT TAACGAACCG CAAACCATTG 101 TGAAGTCGCGTTTGACGGTC GAGCCGAAGA GGGTGGGAGA GCCGCTGGTG 151 TTGGACGGTT CGGCGAAACTCTTGTCCGTC AAAATCAACG GCGTGGCGGC 201 GGATTATGTG TTGGAAGGCG AGACGCTGACGATTGCGGAC GTGCCGTCCG 251 AACGCTTCAC CGTCGAAGTG GAAACCGAAA TCCTGCCGGCGGAAAACAAA 301 TCGCTGATGG GGCTGTATGC GTCCGCCGGT AACCTGTTTA CCCAGTGCGA351 GCCGGAGGGC TTCCGCAAAA TCACGTTCTA TATCGACCGT CCGGATGTCA 401TGTCCAAGTT CACGACCACC ATCGTCGCGG ACAAAAAACG CTATCCCGTT 451 TTGCTCTCCAACGGCAACAA AATCGACGGC GGCGAGTATT CAGACGGCCG 501 CCATTGGGTG AAATGGGAAGACCCGTTTGC CAAACCGAGT TATCTGTTTG 551 CTTTGGTCGC GGGCGATTTG GCGGTCACGGAAGACTATTT CACCACCATG 601 AGCGGCAGAA ACGTCAAAAT CGAGTTTTAC ACCACCGAAGCGGACAAGCC 651 CAAGGTCGGC TTTGCCGTGG AATCGCTGAA AAACGCAATG AAGTGGGACG701 AAACGCGCTT CGGTTTGGAA TACGACTTGG ATATTTTCAT GGTCGTCGCC 751GTGGGCGATT TCAATATGGG TGCGATGGAA AACAAGGGTT TGAACATCTT 801 TAACACCAAGTTCGTCCTTG CCGACAGCCG TACCGCCACC GATACCGATT 851 TTGAAGGCAT CGAATCCGTGGTCGGACACG AATATTTCCA CAACTGGACG 901 GGCAACCGCG TGACCTGCCG CGACTGGTTCCAGCTTTCGC TGAAGGAAGG 951 GTTGACCGTG TTCCGCGACC AAGAATTTTC CGGCGACCGCGCCAGCCGCG 1001 CCGTGCGCCG TATCGAAAAC ATCCGCCTGC TGCGCCAGCA CCAGTTCCCC1051 GAAGACGCAG GTCCGACCGC ACATCCGGTG CGCCCCGCCC GATATGAGGA 1101GATGAACAAT TTCTACACCA TGACCGTTTA TGAAAAAGGC GCGGAAGTGG 1151 TGCGGATGTATCACACCTTG CTCGGCGAAG AGGGCTTCCA AAAAGGTATG 1201 AAGCTCTATT TCCAACGCCACGACGGACAG GCTGTTACCT GCGACGATTT 1251 CCGCGCGGCG ATGGTGGACG CGAACGGCATCAACCTCGAC CAATTCGCCT 1301 TGTGGTACAG CCAAGCAGGT ACGCCGGTTT TAGATGCTCAAGGGCGTCTG 1351 AAAAACAATG TGTTCGAGTT AACCATCAAA CAAACCGTGC CGCCCACGCC1401 CGATATGGCG GACAAACAGC CGATGATGAT TCCCGTCAAA ATCGGGCTGC 1451TGAACTGCAA CGGCGAAGCG GTGGCATTTG ATTATCAGGG CAAACGCGCG 1501 ACCGAAGCCGTGTTGCTGCT GACCGAAGCC GAACAGACCT TCCAGTTCGA 1551 AAGCGTAACC GAAGCCGTCGTTCCCTCGCT GCTGCGCGGG TTCAGCGCGC 1601 CGGTGCATCT GAACTATCCG TACAGCGACGACGACCTGCT GCTTCTGCTC 1651 GCCCATGACA GCGACGCCTT CACGCGCTGG GAAGCCGCACAAACGCTCTA 1701 CCGCCGTGCC GTCGCCGCCA ACCTTGCCGC GCTTTCAGAC GGCGTCGAGT1751 TGCCGAAACA CGAAAAACTG CTTGCCGCCG TCGAAAAAGT CATTTCAGAC 1801GACCTCTTAG ACAACGCTTT CAAAGCCCTG CTTTTGGGTG TGCCGTCTGA 1851 AGCCGAGCTGTGGGACGGCG CGGAAAACAT CGACCCGCTG CGCTACCATC 1901 AGGCGCGCGA AGCCTTGTTGGATATACTTG CCGTCCGCTT TCTGCCGAAA 1951 TGGCACGAAT TGAACCGTCA GGCGGCGAAGCAGGAAAACC AAAGCTACGA 2001 GTACAGCCCC GAAGCCGCCG GTTGGCGCAC GCTGCGCAATGTCTGCCGCG 2051 CCTTCGTCCT GCGCGCCGAT CCCGCGCACA TCGAAACCGT TGCCGAGAAA2101 TACGCCGAAA TGGCGCAAAA CATGACCCAC GAATGGGGCA TCCTGTCCGC 2151CGTCAACGGC AACGAAAGCG ATACGCGCAA CCGCCTGCTG GCGCAGTTTG 2201 CCGACAAGTTTTCAGACGAC GCGCTGGTGA TGGACAAATA TTTCGCCCTC 2251 GTCGGCTCAA GCCGCCGCAGCGACACCCTG CAACAGGTTC AAACCGCCTT 2301 GCAGCATCCG AAGTTCAGCC TCGAAAATCCCAACAAAGCC CGCTCGCTCA 2351 TCGGCAGCTT CAGCCGCAAC GTCCCGCATT TCCACGCAGAAGACGGCAGC 2401 GGCTACCGCT TCATCGCCGA CAAAGTCATC GAAATCGACC GCTTTAACCC2451 GCAGGTCGCC GCCCGCCTGG TGCAGGCGTT CAACCTCTGC AACAAGCTCG 2501AGCCGCACCG CAAAAACTTG GTGAAACAAG CATTGCAGCG CATTCGGGCG 2551 CAGGAAGGATTGTCGAAAGA CGTGGGCGAA ATCGTCGGCA AAATTTTGGA 2601 TTGAThis corresponds to the amino acid sequence <SEQ ID 2170; ORF 665-1.a>:

a665-1.pep 1 MSKTVHYLKD YQTPAYHILK TDLHFDINEP QTIVKSRLTV EPKRVGEPLV 51LDGSAKLLSV KINGVAADYV LEGETLTIAD VPSERFTVEV ETEILPAENK 101 SLMGLYASAGNLFTQCEPEG FRKITFYIDR PDVMSKFTTT IVADKKRYPV 151 LLSNGNKIDG GEYSDGRHWVKWEDPFAKPS YLFALVAGDL AVTEDYFTTM 201 SGRNVKIEFY TTEADKPKVG FAVESLKNAMKWDETRFGLE YDLDIFMVVA 251 VGDFNMGAME NKGLNIFNTK FVLADSRTAT DTDFEGIESVVGHEYFHNWT 301 GNRVTCRDWF QLSLKEGLTV FRDQEFSGDR ASRAVRRIEN IRLLRQHQFP351 EDAGPTAHPV RPARYEEMNN FYTMTVYEKG AEVVRMYHTL LGEEGFQKGM 401KLYFQRHDGQ AVTCDDFRAA MVDANGINLD QFALWYSQAG TPVLDAQGRL 451 KNNVFELTIKQTVPPTPDMA DKQPMMIPVK IGLLNCNGEA VAFDYQGKRA 501 TEAVLLLTEA EQTFQFESVTEAVVPSLLRG FSAPVHLNYP YSDDDLLLLL 551 AHDSDAFTRW EAAQTLYRRA VAANLAALSDGVELPKHEKL LAAVEKVISD 601 DLLDNAFKAL LLGVPSEAEL WDGAENIDPL RYHQAREALLDILAVRFLPK 651 WHELNRQAAK QENQSYEYSP EAAGWRTLRN VCRAFVLRAD PAHIETVAEK701 YAEMAQNMTH EWGILSAVNG NESDTRNRLL AQFADKFSDD ALVMDKYFAL 751VGSSRRSDTL QQVQTALQHP KFSLENPNKA RSLIGSFSRN VPHFHAEDGS 801 GYRFIADKVIEIDRFNPQVA ARLVQAFNLC NKLEPHRKNL VKQALQRIRA 851 QEGLSKDVGE IVGKILD*a665-1/m665-1 97.2% identity in 867 aa overlap        10        20        30        40        50        60 a665-1.pepMSKTVHYLKDYQTPAYHILKTDLHFDINEPTIVKSRLTVEPKRVGEPLVLDGSAKLLSV||||||||||||||||||||||||||||||||:|||||||||:||||||||||||||||| m665-1MSKTVHYLKDYQTPAYHILKTDLHFDINEPQTVVKSRLTVEPQRVGEPLVLDGSAKLLSV        10        20        30        40        50        60        70        80        90       100       110       120 a665-1.pepKINGVAADYVLEGELLTIADVPSERFTVEVETEILPAENKSLMGLYASAGNLFTQCEPEG||||:|||||||||||||| ||||||||||||||||||||||||||||:||||||||||| m665-1KINGAAADYVLEGELLTIAGVPSERFTVEVETEILPAENKSLMGLYASGGNLFTQCEPEG        70        80        90       100       110       120       130       140       150       160       170       180 a665-1.pepFRKITFYIDRPDVMSKFTTTIVADKKRYPVLLSNGNKIDGGEYSDGRHWVKWEDPFAKPS||||||||||||||||||||||||||||||||||||||||||:|||||||||||||:||| m665-1FRKITFYIDRPDVMSKFTTTIVADKKRYPVLLSNGNKIDGGEFSDGRHWVKWEDPFSKPS       130       140       150       160       170       180       190       200       210       220       230       240 a665-1.pepYLFALVAGDLAVTEDYFTTMSGRNVKIEFYTTEADKPKVGFAVESLKNAMKWDETRFGLE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m665-1YLFALVAGDLAVTEDYFTTMSGRNVKIEFYTTEADKPKVGFAVESLKNAMKWDETRFGLE       190       200       210       220       230       240       250       260       270       280       290       300 a665-1.pepYDLDIFMVVAVGDFNMGAMENKGLNIFNTKFVLADSRTATDTDFEGIESVVGHEYFHNWT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m665-1YDLDIFMVVAVGDFNMGAMENKGLNIFNTKFVLADSRTATDTDFEGIESVVGHEYFHNWT       250       260       270       280       290       300       310       320       330       340       350       360 a665-1.pepGNRVTCRDWFQLSLKEGLTVERDQEFSGDRASRAVRRIENIRLLRQHQFPEDAGPTAHPV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m665-1GNRVTCRDWFQLSLKEGLTVERDQEFSGDRASRAVRRIENIRLLRQHQFPEDAGPTAHPV       310       320       330       340       350       360       370       380       390       400       410       420 a665-1.pepRPARYEEMNITFYTMTVYEKGAEVVRMYHTLLGEEGFQKGMKLYFQRHDGQAVTCDDFRAA||| |||||||||||||||||||||||||||||||||||||||||||||||||||||||| m665-1RPASYEEMNITFYTMTVYEKGAEVVRMYHTLLGEEGFQKGMKLYFQRHDGQAVTCDDFRAA       370       380       390       400       410       420       430       440       450       460       470       480 a665-1.pepMVDANGINLDQFALWYSQAGTPVLDAQGRLKNNVFELTIKQTVPPTPDMADKQPMMIPVK|:||||||||||||||||||||||:|:||||||:||||:||||||||||:|||||||||| m665-1MADANGINLDQFALWYSQAGTPVLEAEGRLKNNIFELTVKQTVPPTPDMTDKQPMMIPVK       430       440       450       460       470       480       490       500       510       520       530       540 a665-1.pepIGLLNCNGEAVAFDYQGKRATEAVLLLTEAEQTFQFESVTEAVVPSLLRGFSAPVHLNYP:|||| |||||||||||||||||||||||||||| :|:|||||||||||||||||||||| m665-1VGLLNRNGEAVAFDYQGKRATEAVLLLTEAEQTFLLEGVTEAVVPSLLRGFSAPVHLNYP       490       500       510       520       530       540       550       560       570       580       590       600 a665-1.pepYSDDDLLLLLAHDSDAFTRWEAAQTLYRRAVAANLAALSDGVELPKHEKLLAAVEKVISD||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||| m665-1YSDDDLLLLLAHDSDAFTRWEAAQTLYRRAVAANLATLSDGVELPKHEKLLAAVEKVISD       550       560       570       580       590       600       610       620       630       640       650       660 a665-1.pepDLLDNAFKALLLGVPSEAELWDGAENIDPLRYHQAREALLDILAVRFLPKWHELNRQAAK||||||||||||||||||||||||||||||||||||||||| |||:|||||||||||||| m665-1DLLDNAFKALLLGVPSEAELWDGAENIDPLRYHQAREALLDTLAVHFLPKWHELNRQAAK       610       620       630       640       650       660       670       680       690       700       710       720 a665-1.pepQENQSYEYSPEAAGWRTLRNVCRAFVLRADPAHIETVAEKYAEMAQNMTHEWGILSAVNG|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| m665-1QENQSYEYSPEAAGWRTLRNVCRAFVLRADPAHIETVAEKYGEMAQNMTHEWGILSAVNG       670       680       690       700       710       720       730       740       750       760       770       780 a665-1.pepNESDTRNRLLAQFADKFSDDALVMDKYFALVGSSRRSDTLQQVQTALQHPKFSLENPNKA|||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||| m665-1NESDTRNRLLAQFADKFSDDALVMDKYFALVGSSRRSDTLQQVRTALQHPKFSLENPNKA       730       740       750       760       770       780       790       800       810       820       830       840 a665-1.pepRSLIGSFSRNVPHFHAEDGSGYRFIADKVIEIDRFNPQVAARLVQAFNLCNKLEPHRKNL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m665-1RSLIGSFSRNVPHFHAEDGSGYRFIADKVIEIDRFNPQVAARLVQAFNLCNKLEPHRKNL       790       800       810       820       830       840       850       860 a665-1.pep VKQALQRIRAQEGLSKDVGEIVGKILDX|||||||||||||||||||||||||||| m665-1 VKQALQRIRAQEGLSKDVGEIVGKILDX       850       860The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2171>:

g666.seq 1 ATGCTTTGTA TGAATTATCA ATCAAACTCA GGCGAAGGAG TGCTTGTAGC 51TAAAACATAT TTATTGACTG CATTGATAAT GTCTATGGTA ATCTCCGGAT 101 GTCAAGTCATCCATGCCAAT CAAGGTAAGG TTAATACTAA TTCTGCTGTC 151 ATCGCAGGTG CAGACGCTCACACGCCTGAA CATGTAACGG GACTGACCGA 201 ACAAAAGCAG GTGATTGCAA GTGATTTTATAGTAGCGTCA GCCAATCCAT 251 TAGCAACACA AGCTGGCTAT GATATCTTAA AGCAAGGCGGTAGCGCTGCA 301 GATGCGATGG TGGCGGTGCA GACGACACTA AGCTTGGTAG AGCCACAGTC351 GTCAGGCTTG GGCGGTGGTG CATTTGTGTT GTATTGGGAC AATACCGCCA 401AAACATTGAC CACATTTGAT GGGCGTGAGA CGGCACCGAT GCGTGCGACG 451 CCAGAATTATTTTTGGATAA AGATGGTTAA CCATTGAAAT TTATGGAAGC 501 GGTGGTCGCT CGGTAGGTACGCCTGCTATC CCTAAACTGAThis corresponds to the amino acid sequence <SEQ ID 2172; ORF 666.ng>:

g666.pep 1 MLCMNYQSNS GEGVLVAKTY LLTALIMSMV ISGCQVIHAN QGKVNTNSAV 51IAGADAHTPE HVTGLTEQKQ VIASDFIVAS ANPLATQAGY DILKQGGSAA 101 DAMVAVQTTLSLVEPQSSGL GGGAFVLYWD NTAKTLTTFD GRETAPMRAT 151 PELFLDKDGX PLKFMEAVVARXVRLLSLN*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2173>:

m666.seq 1 ATGCCTTGTA TGAATCATCA ATCAAACTCA GGCGAAGGAG TGCTTGTGGC 51TAAAACATAT TTATTGACTG CATTGATAAT GTCTATGACA ATCTCTGGAT 101 GTCAAGTCATCCATGCCAAT CAAGGTAAGG TTAATACTCA TTCTGCTGTC 151 ATCACAGGTG CAGACGCTCACACGCCTGAA CATGCAACGG GACTGACCGA 201 ACAAAAGCAG GTGATTGCAA GTGATTTTATGGTAGCGTCA GCCAATCCAT 251 TAGCAACACA AGCTGGCTAT GATATCTTAA AGCAAGGCGGTAGCGCTGCA 301 GATGCGATGG TGGCGGTGCA GACGACACTA AGCTTGGTAG AGCCACAGTC351 GTCAGGCTTG GGCGGTGGTG CATTTGTGTT GTATTGGGAT AATACCGCCA 401AAACATTGAC CACATTTGAT GGGCGTGAGA CGGCACCGAT GCGTGCGACG 451 CCGGAATTATTTTTGGATAA AGATGGTCAA CCATTGAAAT TTATGGAAGC 501 GGTGGTCGTG GTCGCTCGGTGGGTACGCCT GCTATCCCTA AACTGAThis corresponds to the amino acid sequence <SEQ ID 2174; ORF 666>:

m666.pep 1 MPCMNHQSNS GEGVLVAKTY LLTALIMSMT ISGCQVIHAN QGKVNTHSAV 51ITGADAHTPE HATGLTEQKQ VIASDFMVAS ANPLATQAGY DILKQGGSAA 101 DAMVAVQTTLSLVEPQSSGL GGGAFVLYWD NTAKTLTTFD GRETAPMRAT 151 PELFLDKDGQ PLKFMEAVVVVARWVRLLSL N*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m666/g666 93.9% identity in 181 aa overlap         10        20        30        40        50         60 m666.pep MPCMNHQSNSGEGVLVAKTYLLTALIMSMTISGCQVIHANQGKVNTHSAVITGADAHTPE | |||:|||||||||||||||||||||||:||||||||||||||||:||||:|||||||| g666 MLCMNYQSNSGEGVLVAKTYLLTALIMSMVISGCQVIHANQGKVNTNSAVIAGADAHTPE         10        20        30        40        50        60         70        80        90       100       110       120 m666.pep HATGLTEQKQVIASDFMVASANPLATQAGYDILKQGGSAADAMVAVQTTLSLVEPQSSGL |:||||||||||||||:||||||||||||||||||||||||||||||||||||||||||| g666 HVTGLTEQKQVIASDFIVASANPLATQAGYDILKQGGSAADAMVAVQTTLSLVEPQSSGL         70        80        90       100       110       120        130       140       150       160       170       180 m666.pep GGGAFVLYWDNTAKTLTTFDGRETAPMRATPELFLDKDGQPLKFMEAVVVVARWVRLLSL ||||||||||||||||||||||||||||||||||||||| ||||||||| || |||||| g666 GGGAFVLYWDNTAKTLTTFDGRETAPMRATPELFLDKDGXPLKFMEAVV--ARXVRLLSL        130       140       150       160         170 m666.pep  NX  ||g666  NX 180The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2175>:

a666.seq 1 ATGCCTTGTA TGAATCATCA ATCAAACTCA GGCGAAGGAG TGCTTGTGGC 51TAAAACATAT TTATTGACTG CATTGATAAT GTCTATGACA ATCTCTGGAT 101 GTCAAGTCATCCATGCCAAT CAAGGTAAGG TTAATACTCA TTCTGCTGTC 151 ATCACAGGTG CAGACGCTCACACGCCTGAA CATGCAACGG GACTGACCGA 201 ACAAAAGCAG GTGATTGCAA GTGATTTTATGGTAGCGTCA GCCAATCCAT 251 TAGCAACACA AGCTGGCTAT GATATCTTAA AGCAAGGCGGTAGCGCTGCA 301 GATGCGATGG TGGCGGTGCA GACGACACTA AGCTTGGTAG AGCCACAGTC351 GTCAGGCTTG GGCGGTGGTG CATTTGTGTT GTATTGGGAT AATACCGCCA 401AAACATTGAC CACATTTGAT GGGCGTGAGA CGGCACCGAT GCGTGCGACG 451 CCGGAATTATTTTTGGATAA AGATGGTCAA CCATTGAAAT TTATGGAAGC 501 GGTGGTCGTG GTCGCTCGGTGGGTACGCCT GCTATCCCTA AACTGAThis corresponds to the amino acid sequence <SEQ ID 2176; ORF 666.a>:

a666.pep 1 MPCMNHQSNS GEGVLVAKTY LLTALIMSMT ISGCQVIHAN QGKVNTHSAV 51ITGADAHTPE HATGLTEQKQ VIASDFMVAS ANPLATQAGY DILKQGGSAA 101 DAMVAVQTTLSLVEPQSSGL GGGAFVLYWD NTAKTLTTFD GRETAPMRAT 151 PELFLDKDGQ PLKFMEAVVVVARWVRLLSL N* m666/a666 100.0% identity in 181 aa overlap        10        20        30        40        50        60 m666.pepMPCMNHQSNSGEGVLVAKTYLLTALIMSMTISGCQVIHANQGKVNTHSAVITGADAHTPE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a666MPCMNHQSNSGEGVLVAKTYLLTALIMSMTISGCQVIHANQGKVNTHSAVITGADAHTPE        10        20        30        40        50        60        70        80        90       100       110       120 m666.pepHATGLTEQKQVIASDFMVASANPLATQAGYDILKQGGSAADAMVAVQTTLSLVEPQSSGL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a666HATGLTEQKQVIASDFMVASANPLATQAGYDILKQGGSAADAMVAVQTTLSLVEPQSSGL        70        80        90       100       110       120       130       140       150       160       170       180 m666.pepGGGAFVLYWDNTAKTLTTFDGRETAPMRATPELFLDKDGQPLKFMEAVVVVARWVRLLSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a666GGGAFVLYWDNTAKTLTTFDGRETAPMRATPELFLDKDGQPLKFMEAVVVVARWVRLLSL       130       140       150       160       170       180 m666.pep NX|| a666 NXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2177>:

g667.seq 1 atgcggtttg tcttctgttt gggcgGAGAG ATAGtttctg atccgtgtga 51tttccAtttg gtattcgtcc gcgtcgaatc tgccgctgAc CAGAcagaaa 101 cgCAGatacatCaaatacgt attcacggca tcggtttcgc aatAAttgcg 151 GAtttccttc agcgtgcccgcgtgGAacgc ttcccacact ttgctgccgt 201 ccataCCCAg ctTGCCCGGA AAGCCGCACAGTTTcgcCat atcgtccagC 251 GGCACATTcg ccctcggctG GTAAAGCGCG AGCAAATCCATCAAATCGCA 301 GTGGCGTTGG TGATAACGGC TGATGTAGTT GTTCCActtg AAATCGCGGC351 tgtcgccgAA ATCGccgTCG CCCGTATCCC AATAGCGCGC GGCGTTGATG 401CCGTATATCA GGGAGCGGTA ATGCAGTACG GGCAGGTCGA AACCGCCGCC 451 GTTCCAGCTGACCAGTTGCG GCGTATGTTT TTCAACCAAT TCGAAAAACT 501 TGGCAATCAC GACTTCTTCGCCATCGTCCA TCTCGCCGAT GGTGCCGACA 551 TGAACCTTGT CCTGCCCCCA GCGCATACAGCAGGAAACCG CCACAACCTG 601 ATGGAGGTGG TGCTGCATAA AATCGCCGCC GGTCTGTGCGCGGCGTTTCT 651 GCTGCGCGAA CAGCACCACT TCGTCATCCG GCAGGGAAGA CGGCAAGTCA701 TACAACGTAC GGATACCCTG CACATCGGGT ACGGTTTCAA TATCGAAAGC 751CAAAATCGTA TTCATGGCAg tACCTTGCAT tcaAAAACAG ACtTGCGCCT 801 ATTgTgtcaTTAAThis corresponds to the amino acid sequence <SEQ ID 2178; ORF 667.ng>:

g667.pep 1 MRFVFCLGGE IVSDPCDFHL VFVRVESAAD QTETQIHQIR IHGIGFAIIA 51DFLQRARVER FPHFAAVHTQ LARKAAQFRH IVQRHIRPRL VKREQIHQIA 101VALVITADVV VPLEIAAVAE IAVARIPIAR GVDAVYQGAV MQYGQVETAA 151 VPADQLRRMFFNQFEKLGNH DFFAIVHLAD GADMNLVLPP AHTAGNRHNL 201 MEVVLHKIAA GLCAAFLLREQHHFVIRQGR RQVIQRTDTL HIGYGFNIES 251 QNRIHGSTLH SKTDLRLLCH *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2179>:

m667.seq (PARTIAL) 1 ATGCGGCTTT TCCCCGGCTT GTGCGGACAG GTAATTCCGCATCCGTTTGA 51 TTTCCATTTC GTATTCGTCC GCATCCAGCC TGCCGCTGAC CAGACAGAAA 101CGCAGGTACA TCAGATAAGT GTTTGCCGCG TCGGTTTCGC AATAATTGCG 151 GATTTCCTTCAGCCTGCCCG TATGGAATGC CTCCCAAACC TTGCTGCCGT 201 CCATACCCAG CTTGCCCGGAAAACCGCACA GTTTCGCCAT ATCGTCCAGC 251 GGCACGTTTG CCCTCGGCTG GTAAAGCGCGAGCAAATCCA TCAAATCGCA 301 GTGGCGTTGG TGATAACGGC TGATGTAGTT GTTCCACTTGAAATCGCGGC 351 TGTCGCCGAA ATCGCCGTCG CCCATATCCC AATAGCGCGC GGCGTTGATG401 CCGTATATCA GGGAGCGGTA ATGCAGTACG GGCAGATCGA AACCGCCGCC 451GTTCCAACTG ACCAGTTGCG GCGTATGTTT TTCAATCAAT TCGAAAAATT 501 TAGCAATGACCACTTCCTCG CCGTCATCCA TCTCGCCGAT GGTGCCGACA 551 TGTACTTTAT CCTGCCCCCAACGCATGCAG CACGAAATCG CCACAACCTG 601 ATGAAGATGA TGCTGCATAA AATCGCCGCCCGTCTGAGCA CGGCGTTTGT 651 GCTGGGCAAT CAGCACCACT TG...This corresponds to the amino acid sequence <SEQ ID 2180; ORF 667>:

m667.pep (partial) 1 MRLFPGLCGQ VIPHPFDFHF VFVRIQPAAD QTETQVHQISVCRVGFAIIA 51 DFLQPARMEC LPNLAAVHTQ LARKTAQFRH IVQRHVCPRL VKREQIHQIA 101VALVITADVV VPLEIAAVAE IAVAHIPIAR GVDAVYQGAV MQYGQIETAA 151 VPTDQLRRMFFNQFEKFSND HFLAVIHLAD GADMYFILPP THAARNRHNL 201 MKMMLHKIAA RLSTAFVLGNQHHL...Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m667/g667 75.0% identity in 224 aa overlap        10        20        30        40        50        60 m667.pepMRLFPGLCGQVIPHPFDFHFVFVRIQPAADQTETQVHQISVCRVGFAIIADFLQPARMEC||:   | |:::  | |||:||||:: ||||||||:||| :  :|||||||||| ||:| g667MRFVFCLGGEIVSDPCDFHLVFVRVESAADQTETQIHQIRIHGIGFAIIADFLQRARVER        10        20        30        40        50        60        70        80        90       100       110       120 m667.pepLPNLAAVHTQLARKTAQFRHIVQRHVCPRLVKREQIHQIAVALVITADVVVPLEIAAVAE :|::||||||||||:||||||||||: |||||||||||||||||||||||||||||||| g667FPHFAAVHTQLARKAAQFRHIVQRHIRPRLVKREQIHQIAVALVITADVVVPLEIAAVAE        70        80        90       100       110       120       130       140       150       160       170       180 m667.pepIAVAHIPIARGVDAVYQGAVMQYGQIETAAVPTDQLRRMFFNQFEKFSNDHFLAVIHLAD||||:||||||||||||||||||||:||||||:|||||||||||||::|  |:|::|||| g667IAVARIPIARGVDAVYQGAVMQYGQVETAAVPADQLRRMFFNQFEKLGNHDFFAIVHLAD       130       140       150       160       170       180       190       200       210       220 m667.pepGADMYFILPPTHAARNRHNLMKMMLHKIAARLSTAFVLGNQHHL|||| ::|||:|:| ||||||:::|||||| | :||:| |||: g667GADMNLVLPPAHTAGNRHNLMEVVLHKIAAGLCAAFLLREQHHFVIRQGRRQVIQRTDTL       190       200       210       220       230       240 g667HIGYGFNIESQNRIHGSTLHSKTDLRLLCHX        250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2181>:

a667.seq 1 ATGCGGTTTG TCTTCTGTTT GGGCGGAGAG ATAGTTTCTG ATCCGCTTGA 51TTTCCATTTC GTATTCGTCT GCGTCGAATC TGCCGCTGAC CAGACAGAAA 101 CGCAGATACATCAGATAGGT ATTTACCGCA TCGGTTTCGC AATAATTGCG 151 GATTTCCTTC AGCCTGCCCGCGTGGAACGC CTCCCACACC TTGCTGCCGT 201 CCATACCCAG CTTGCCCGGA AAACCGCACAGTTTCGCCAT ATCGTCCAAC 251 GGCACATTCG CCCTCGGCTG GTAAAGCGCG AGCAAATCCATCAAATCGCA 301 ATGACGTTGG TGGTAGCGGC TGATGTAGTT GTTCCACTTG AAATCGCGGC351 TGTCGCCGAA ATCGCCGTCG CCCATATCCC AATAGCGCGC GGCGTTGATG 401CCGTGTAGCA GCGAACGGTA ATGCAGAACC GGCAGGTCGA AACCGCCGCC 451 GTTCCAACTGACCAGTTGCG GCGTATGTTT TTCAATCAAC TCGAAAAATT 501 TGGCGATAAC CACTTCCTCGCCGTCATCCA TCTCGCCGAT TGTACCGACA 551 TGGACTTTAT CCTGCCCCCA ACGCATGCAGCACGAAATCG CCACAATCTG 601 ATGAAGATGA TGCTGCATAA AATCCCCACC CGTCTGAGCACGGCGTTTTT 651 GCTGGGCAAA CAGCACCACT TCATCGTCGG GCAGCGAGGA CGGCAAGTCA701 TACAGCGTAC GGATACACTG CACATCGGGT ACGGTTTCAA TATCGAAAGC 751CAAAATCGTG GTCATGACAG CACCTTGTAT TTAAAA.CAG ACTTGCGCCT 801 ATTGTGTCATTAAThis corresponds to the amino acid sequence <SEQ ID 2182; ORF 667.a>:

a667.pep 1 MRFVFCLGGE IVSDPLDFHF VFVCVESAAD QTETQIHQIG IYRIGFAIIA 51DFLQPARVER LPHLAAVHTQ LARKTAQFRH IVQRHIRPRL VKREQIHQIA 101MTLVVAADVV VPLEIAAVAE IAVAHIPIAR GVDAV*QRTV MQNRQVETAA 151 VPTDQLRRMFFNQLEKFGDN HFLAVIHLAD CTDMDFILPP THAARNRHNL 201 MKMMLHKIPT RLSTAFLLGKQHHFIVGQRG RQVIQRTDTL HIGYGFNIES 251 QNRGHDSTLY LKXDLRLLCH * m667/a66779.0% identity in 224 aa overlap        10        20        30        40        50        60 m667.pepMRLFPGLCGQVIPHPFDFHFVFVRIQPAADQTETQVHQISVCRVGFAIIADFLQPARMEC||:   | |:::  |:||||||| :: ||||||||:|||:: |:|||||||||||||:| a667MRFVFCLGGEIVSDPLDFHFVFVCVESAADQTETQIHQIGIYRIGFAIIADFLQPARVER        10        20        30        40        50        60        70        80        90       100       110       120 m667.pepLPNLAAVHTQLARKTAQFRHIVQRHVCPRLVKREQIHQIAVALVITADVVVPLEIAAVAE||:||||||||||||||||||||||: |||||||||||||::||::|||||||||||||| a667LPHLAAVHTQLARKTAQFRHIVQRHIRPRLVKREQIHQIAMTLVVAADVVVPLEIAAVAE        70        80        90       100       110       120       130       140       150       160       170       180 m667.pepIAVAHIPIARGVDAVYQGAVMQYGQIETAAVPTDQLRRMFFNQFEKFSNDHFLAVIHLAD||||||||||||||| | :|||  |:|||||||||||||||||:|||:::|||||||||| a667IAVAHIPIARGVDAVXQRTVMQNRQVETAAVPTDQLRRMFFNQLEKFGDNHFLAVIHLAD       130       140       150       160       170       180       190       200       210       220 m667.pepGADMYFILPPTHAARNRHNLMKMMLHKIAARLSTAFVLGNQHHL :|| ||||||||||||||||||||||| :||||||:||:|||: a667CTDMDFILPPTHAARNRHNLMKMMLHKIPTRLSTAFLLGKQHHFIVGQRGRQVIQRTDTL       190       200       210       220       230       240 a667HIGYGFNIESQNRGHDSTLYLKXDLRLLCHX        250       260       270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2183>:

g669.seq 1 ATGCGCCGCA TCGTTAAAAA ACACCAGCCC GTAAACGCGC CACATATCGT 51TTTGGAAATT CGGATAATGA AACTGCATCG CGCGTTTGTC TTCCTTGGGC 101 GGAAACGTCCCCATCATCAT GACCGCAGCC TTCGGCGGCA ACACGGGATC 151 GAAGGGATGG GTTTCGATTTCAAGCAGATT TTCAGACACG TTCAATCCTC 201 CAACAGGCAA AGCGGCAGAC AGCCGGTTTGCACCAAACCG CCAAACACGG 251 CAAGCCTTCA AACAGCATTA TCACGCCCTG CCGTTTTCGGTTACAATGCC 301 GACATCAAAC GGATACTGTA AThis corresponds to the amino acid sequence <SEQ ID 2184; ORF 669.ng>:

g669.pep 1 MRRIVKKHQP VNAPHIVLEI RIMKLHRAFV FLGRKRPHHH DRSLRRQHGI 51EGMGFDFKQI FRHVQSSNRQ SGRQPVCTKP PNTASLQTAL SRPAVFGYNA 101 DIKRILThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2185>:

m669.seq 1 ATGCGCCGCA TCATTAAAAA ACACCAGCCC ATAAACGCGC CACATATCGT 51TTTGGAAATT CGGATAATGA AACTGCATCG CGCGTTTGTC TTCCTTGGGC 101 GGAAACGTCCCCATCATCAT GACAGCAGCC TTCGGCGGCA ACACGGGATC 151 GAAGGGATGG GTTTCGATTTCAAGCAGATT TTCAGACACG TTCAATCCTC 201 CAACAGGCAA AACGGCAGAC AGCCGGTTTGCACCAAACCG CCAAACACGG 251 CAAGCCTTCA AACAGCATTA TCACGCCCTG CCGTTTTCGGTTACAATGCC 301 GACATCAAAC GGATACTGTA AThis corresponds to the amino acid sequence <SEQ ID 2186; ORF 669>:

m669.pep 1 MRRIIKKHQP INAPHIVLEI RIMKLHRAFV FLGRKRPHHH DSSLRRQHGI 51EGMGFDFKQI FRHVQSSNRQ NGRQPVCTKP PNTASLQTAL SRPAVFGYNA 101 DIKRIL*Computer analysis of this amino acid sequence gave the followingresults:

m669/g669 96.2% identity in 106 aa overlap        10        20        30        40        50        60 m669.pepMRRIIKKHQPINAPHIVLEIRIMKLHRAFVFLGRKRPHHHDSSLRRQHGIEGMGFDFKQI||||:|||||:|||||||||||||||||||||||||||||| |||||||||||||||||| g669MRRIVKKHQPVNAPHIVLEIRIMKLHRAFVFLGRKRPHHHDRSLRRQHGIEGMGFDFKQI        10        20        30        40        50        60        70        80        90       100 m669.pepFRHVQSSNRQNGRQPVCTKPPNTASLQTALSRPAVFGYNADIKRILX||||||||||:|||||||||||||||||||||||||||||||||||| g669FRHVQSSNRQSGRQPVCTKPPNTASLQTALSRPAVFGYNADIKRILX        70        80        90       100The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2187>:

a669.seq 1 ATGCGCCGCA TCATTAAAAA ACACCAGCCC GTAAACGCGC CACATATCGT 51TTTGGAAATT CGGATAATGA AACTGCATCG CGCGTTTGTC TTCCTTGGGC 101 GGAAACGTCCCCATCATCAT GACCGCAGCC TTCGGCGGCA ACACGGAATC 151 GAAGGGATGG GTTTCGATTTCAAGCAGATT TTCAGACACG TTCAATCCTC 201 CAACAGGCAA AACGGCAGAC AGCCGGTTTGCACCAAACCG CCAAACACGG 251 CAAGCCTTCA AACAGCATTA TCACGCCCTG CCGTTTTCGGTTACAATGCC 301 GACATCAAAC GGATACTGTA AThis corresponds to the amino acid sequence <SEQ ID 2188; ORF 669.a>:

a669.pep 1 MRRIIKKHQP VNAPHIVLEI RIMKLHRAFV FLGRKRPHHH DRSLRRQHGI 51EGMGFDFKQI FRHVQSSNRQ NGRQPVCTKP PNTASLQTAL SRPAVFGYNA 101 DIKRIL*m669/a669 98.1% identity in 106 aa overlap        10        20        30        40        50        60 m669.pepMRRIIKKHQPINAPHIVLEIRIMKLHRAFVFLGRKRPHHHDSSLRRQHGIEGMGFDFKQI||||:|||||:|||||||||||||||||||||||||||||| |||||||||||||||||| a669MRRIIKKHQPVNAPHIVLEIRIMKLHRAFVFLGRKRPHHHDRSLRRQHGIEGMGFDFKQI        10        20        30        40        50        60        70        80        90       100 m669.pepFRHVQSSNRQNGRQPVCTKPPNTASLQTALSRPAVFGYNADIKRILX||||||||||||||||||||||||||||||||||||||||||||||| a669FRHVQSSNRQNGRQPVCTKPPNTASLQTALSRPAVFGYNADIKRILX        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2189>:

g670.seq 1 ATGACTTGTT GCAGGAACTG CTTGGCGCGT TCGTGTTTCG GGTTGGTGAA 51AAACGCTTCC GGCGTTTCGT CTTCAAGGAT TTGCCCTTTA TCGACGAAAA 101 TCACGCGGTCGGCAACTTCG CGGGCAAACC CCATTTCGTG GGTTACGCAC 151 ATCATCGTCA TGCCGCTTTCCGCCAAGTCT TTCATCACTT TCAACACTTC 201 GCCGACCATT TCGGGGTCGA GTGCGGAAGTCGGCTCGTCA AACAGCATCA 251 CGCGCGGCTC CATCGCCAGC CCGCGCGCAA TCGCCACGCGTTGCTGCTGG 301 CCGCCGGAAA GTTGGGAAGG GAAGGCGTCT TTTTTGTGTG CCAGTCCGAC351 GCGTTCCAAA AGCTCCATTG CCTTTTTCTC CGCCTGTTCC GCATTTTGCC 401CCTTAACCTT CATCGGTGCG AGGGTGATGT TGTCCAACAC GGTCAGGTGC 451 GGGTAGThis corresponds to the amino acid sequence <SEQ ID 2190; ORF 670.ng>:

g670.pep 1 MTCCRNCLAR SCFGLVKNAS GVSSSRICPL STKITRSATS RANPISWVTH 51IIVMPLSAKS FITFNTSPTI SGSSAEVGSS NSITRGSIAS PRAIATRCCW 101 PPESWEGKASFLCASPTRSK SSIAFFSACS AFCPLTFIGA RVMLSNTVRC 151 G*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2191>:

m670.seq 1 ATGACCTGTT GCAGGAACTG CTTGGCGCGT TCGTGTTTCG GGTTGGTAAA 51AAACGCTTCG GGCGTTTCGT CTTCGAGGAT TTGCCCTTTA TCGACGAAAA 101 TCACGCGGTCGGCAACTTCG CGGGCAAACC CCATTTCGTG GGTTACGCAC 151 ATCATCGTCA TGCCGCTTTCTGCCAAGTCT TTCATCACTT TCAACACTTC 201 GCCGACCATT TCGGGGTCGA GTGCGGAGGTCGGTTCGTCA AACAACATTA 251 CGCGCGGTTC CATCGCCAAA CCGCGTGCAA TCGCCACGCGTTGCTGCTGG 301 CCGCCGGAAA GTTGGGAAGG GAAGGCGTCT TTTTTGTGTG CCAGTCCGAC351 GCGTTCCAAA AGCTCCATTG CCTTTTTCTC CGCCTGTTCC GCATTTTGCC 401CCTTAACCTT CATCGGTGCG AGGGTAATGT TTTCCAACAC GGTCAGGTGC 451 GGGTAGThis corresponds to the amino acid sequence <SEQ ID 2192; ORF 670>:

m670.pep 1 MTCCRNCLAR SCFGLVKNAS GVSSSRICPL STKITRSATS RANPISWVTH 51IIVMPLSAKS FITFNTSPTI SGSSAEVGSS NNITRGSIAK PRAIATRCCW 101 PPESWEGKASFLCASPTRSK SSIAFFSACS AFCPLTFIGA RVMFSNTVRC 151 G*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m670/g670 98.0% identity in 151 aa overlap        10        20        30        40        50        60 m670.pepMTCCRNCLARSCFGLVKNASGVSSSRICPLSTKITRSATSRANPISWVTHIIVMPLSAKS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g670MICCRNCLARSCFGLVKNASGVSSSRICPLSTKITRSATSRANPISWVIHIIVMPLSAKS        10        20        30        40        50        60        70        80        90       100       110       120 m670.pepFITFNTSPTISGSSAEVGSSNNITRGSIAKPRAIATRCCWPPESWEGKASFLCASPTRSK|||||||||||||||||||||:|||||||:|||||||||||||||||||||||||||||| g670FITFNTSPTISGSSAEVGSSNSITRGSIASPRAIATRCCWPPESWEGKASFLCASPTRSK        70        80        90       100       110       120       130       140       150 m670.pep SSIAFFSACSAFCPLTFIGARVMFSNTVRCGX|||||||||||||||||||||||:|||||||| g670 SSIAFFSACSAFCPLIFIGARVMLSNIVRCGX       130       140       150The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2193>:

a670.seq 1 ATGACCTGTT GCAGGAACTG CTTGGCGCGT TCGTGTTTCG GGTTGGTAAA 51AAACGCTTCC GGCGTTTCGT CTTCGAGGAT TTGCCCTTTA TCGACGAAAA 101 TCACGCGGTCGGCAACTTCG CGGGCAAACC CCATTTCGTG GGTTACGCAC 151 ATCATGGTCA TACCGCTTTCCGCCAAGTCT TTCATCACTT TCAACACTTC 201 GCCGACCATT TCGGGGTCGA GTGCGGAGGTCGGTTCGTCA AACAACATTA 251 CGCGCGGTTC CATCGCCAAA CCGCGTGCAA TCGCCACGCGTTGCTGCTGG 301 CCGCCGGAAA GTTGGGAAGG GAAGGCGTCT TTTTTGTGTG CCAGTCCGAC351 GCGTTCCAAA AGTTCCATCG CTTTTTTCTC TGCCTGTTCC GCATTTTGAC 401CTTTAACCTT CATCGGTGCG AGGGTAATGT TTTCCAACAC GGTCAGGTGC 451 GGGTAGThis corresponds to the amino acid sequence <SEQ ID 2194; ORF 670.a>:

a670.pep 1 MTCCRNCLAR SCFGLVKNAS GVSSSRICPL STKITRSATS RANPISWVTH 51IMVIPLSAKS FITFNTSPTI SGSSAEVGSS NNITRGSIAK PRAIATRCCW 101 PPESWEGKASFLCASPTRSK SSIAFFSACS AF*PLTFIGA RVMFSNTVRC 151 G* m670/a670 98.0%identity in 151 aa overlap        10        20        30        40        50        60 m670.pepMTCCRNCLARSCFGLVKNASGVSSSRICPLSTKITRSATSRANPISWVTHIIVMPLSAKS|||||||||||||||||||||||||||||||||||||||||||||||||||:|:|||||| a670MTCCRNCLARSCFGLVKNASGVSSSRICPLSTKITRSATSRANPISWVTHIMVIPLSAKS        10        20        30        40        50        60        70        80        90       100       110       120 m670.pepFITFNTSPTISGSSAEVGSSNNITRGSIAKPRAIATRCCWPPESWEGKASFLCASPTRSK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a670FITFNTSPTISGSSAEVGSSNNITRGSIAKPRAIATRCCWPPESWEGKASFLCASPTRSK        70        80        90       100       110       120       130       140       150 m670.pep SSIAFFSACSAFCPLTFIGARVMFSNTVRCGX|||||||||||| ||||||||||||||||||| a670 SSIAFFSACSAFXPLTFIGARVMFSNTVRCGX       130       140       150The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2195>:

g671.seq 1 ATGATCAGCA GGGTAACAAT CAAAACGCCT TTCAATGCAC CGAATACACC 51GCCCAAAATG CGGTTGGCAA AGCCCAGACC GACCGCCGAA ACTGCGCCGG 101 TCAGCAGCGAACGGAGCATT TTCTGGATCA GACAGGCAAT GACGAACAGG 151 GAAATGAATG ACAGagccaaTGCAAACAgg cggggTTGGA ACGaggCAAA 201 GGCGAGGTcg gcgaaggGTG CGGCaaAGAGTTTggcaaAA AAGAaggAAA 251 ccaccCATGC cACCATCgaa ccTGCTTCCG CAATCACGCCGCGCATCGTG 301 GAAATGACGA TGCAGGCGGC GATGACGGcg gAGGCGAGGA GGTCGGCAAT351 GGGGAGGCTA TTCATTCGTT ACCTGGCCGG CGATGCCGTG CACGCGCAGT 401TTGTTCAAAT CGCGTTCGGC ATCCCTTGCG TTTTTATAGT TGCTTGAThis corresponds to the amino acid sequence <SEQ ID 2196; ORF 671.ng>:

g671.pep 1 MISRVTIKTP FNAPNTPPKM RLAKPRPTAE TAPVSSERSI FWIRQAMTNR 51EMNDRANANR RGWNEAKARS AKGAAKSLAK KKETTHATIE PASAITPRIV 101 EMTMQAAMTAEARRSAMGRL FIRYLAGDAV HAQFVQIAFG IPCVFIVA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2197>:

m671.seq 1 ATGACCAGCA GGGTAACAAT CAAAACGCCT TTCAATGCAC CGAATACGCC 51GCCCAAAATG CGGTTGGCAA AGCCCAAACC GACCGCCGAA ACTGCGCTGG 101 TCAGCAGCGAACGGAGCATT TTCTGGATCA GACAGGCAAT GACGAACAGG 151 GAAATGAACG ACAGAGCCAATGCAAACAGG CGGGGTTGGA ACGAGGCAAA 201 GGCGAGGTCG GCGAAGGAGG CGGCAAAGAGTTTGGCGAAA AAGAAGGAAA 251 CCACCCATGC CGCCATTGAG CCTGCCTCCG CAATCACGCCGCGCATCGCG 301 GATAGCACGA TGCAGGCGGC GATGACGGCG GAGACGAGGA GGTCGGCAAT351 GGGGAGGCTA TTCATTCGTT ACCTGACCGG CGATACCGTG TACGCGCAAT 401TTGTTCAAAT CGCGTTCGGC ATCCCTTGCG TTTTTATAGT TGCTTGAThis corresponds to the amino acid sequence <SEQ ID 2198; ORF 671>:

m671.pep 1 MTSRVTIKTP FNAPNTPPKM RLAKPKPTAE TALVSSERSI FWIRQAMTNR 51EMNDRANANR RGWNEAKARS AKEAAKSLAK KKETTHAAIE PASAITPRIA 101 DSTMQAAMTAETRRSAMGRL FIRYLTGDTV YAQFVQIAFG IPCVFIVA*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m671/g671 91.9% identity in 148 aa overlap        10        20        30        40        50        60 m671.pepMTSRVTIKTPFNAPNTPPKMRLAKPKPTAETALVSSERSIFWIRQAMTNREMNDRANANR| |||||||||||||||||||||||:|||||| ||||||||||||||||||||||||||| g671MISRVTIKTPFNAPNTPPKMRLAKPRPTAETAPVSSERSIFWIRQAMTNREMNDRANANR        10        20        30        40        50        60        70        80        90       100       110       120 m671.pepRGWNEAKARSAKEAAKSLAKKKETTHAAIEPASAITPRIADSTMQAAMTAETRRSAMGRL|||||||||||| ||||||||||||||:|||||||||||:: |||||||||:|||||||| g671RGWNEAKARSAKGAAKSLAKKKETTHATIEPASAITPRIVEMTMQAAMTAEARRSAMGRL        70        80        90       100       110       120       130       140       149 m671.pep FIRYLTGDTVYAQFVQIAFGIPCVFIVAX|||||:||:|:|||||||||||||||||| g671 FIRYLAGDAVHAQFVQIAFGIPCVFIVAX       130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2199>:

a671.seq 1 ATGACCAGCA GGGTAATAAT CAAAATGCCT TTCAATGCAC CGAATACGCC 51GCCCAAAATG CGGTTGGCAA AGCCCAAACC GACCGCCGAA ACTGCCCCGG 101 TCAGCAGCGAGCGGAGTATT TTCTGGATCA GACAGGCAAT GACGAATAGG 151 GAAATGAACG ACAGAGCCAATGCAAACAGG CGGGGTTGGA ACGATGCAAA 201 GGCGATGTCG GCGAAGGGTG CGGCAAAGAGTTTGGCGAAA AAAAAGGCAA 251 CCACCCATGC CGCCATTGAG CCAGCCTCCG CAATCACGCCGCGCATCGCG 301 GATAGCACGA TGCAGGCGGC GATGATGGCG GAGACGAGGA GGTCGGCAAC351 GGGGAGGTTA TTCATTCGTT ACCTGACCGG CGATACCGTG TACGCGCAAT 401TTGTTCAAAT CGCGTTCGGC ATCCCTTGCG TTTTTATAGT TGCTTGAThis corresponds to the amino acid sequence <SEQ ID 2200; ORF 671.a>:

a671.pep 1 MTSRVIIKMP FNAPNTPPKM RLAKPKPTAE TAPVSSERSI FWIRQAMTNR 51EMNDRANANR RGWNDAKAMS AKGAAKSLAK KKATTHAAIE PASAITPRIA 101 DSTMQAAMMAETRRSATGRL FIRYLTGDTV YAQFVQIAFG IPCVFIVA* m671/a671 93.9% identity in148 aa overlap        10        20        30        40        50        60 m671.pepMTSRVTIKTPFNAPNTPPKMRLAKPKPTAETALVSSERSIFWIRQAMTNREMNDRANANR||||| || ||||||||||||||||||||||| ||||||||||||||||||||||||||| a671MTSRVIIKMPFNAPNTPPKMRLAKPKPTAETAPVSSERSIFWIRQAMTNREMNDRANANR        10        20        30        40        50        60        70        80        90       100       110       120 m671.pepRGWNEAKARSAKEAAKSLAKKKETTHAAIEPASAITPRIADSTMQAAMTAETRRSAMGRL||||:||| ||| ||||||||| ||||||||||||||||||||||||| ||||||| ||| a671RGWNDAKAMSAKGAAKSLAKKKATTHAAIEPASAITPRIADSTMQAAMMAETRRSATGRL        70        80        90       100       110       120       130       140       149 m671.pep FIRYLTGDTVYAQFVQIAFGIPCVFIVAX||||||||||||||||||||||||||||| a671 FIRYLTGDTVYAQFVQIAFGIPCVFIVAX       130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2201>:

g672.seq 1 ATGAGGAAAA TCCGCACCAA AATCTGCGGC ATCACCACAC CGGAAGACGC 51ACTGTATGCC GCCCACGCCG GCGCAGACGC ATTGGGACTG GTTTTTTACC 101 CCCAAAGCCCCCGCGCTATC GACATCATTA AAGCACAAAA AATCGCCGCC 151 GCACTGCCGC CGTTTGTCAGCGTTGTCGCC CTTTTCGTCA ACGAAAGCGC 201 GCAAAACATC CGCCGCATCC TTGCCGAAGTGCCGATACAC ATCATCCAAT 251 TCCACGGCGA CGAAGACGAT GCATTCTGCC GGCAGTTCGACCGCCCCTAT 301 ATTAAAGCCA TTCGTGTTCA GACGGCATCA GACATCCGAA ACGCCGCCAC351 GCGCTTCCCC AACGCTCAGG CACTGCTGTT CGATGCCTAT CACCCTTCGG 401AATACGGCGG CACCGGACAC CGCTTCGact GGacgctgtt ggcggAATAT 451 TCGGGCAAGCCGTGGGTGCT TGCCGGCGGG CTGACCCCTG AAAACGTCGG 501 CGAAGCCGTC CGCATCACCGGAGCGGAAGC GGTCGACGTA TCCGGCGGCG 551 TGGAAGCGTC TAAAGGCAAA AAAGACCCCGCCAAAGTCGC CGCCTTTATC 601 GCAACCGCCA ACCGCCTATC CCGTTAAThis corresponds to the amino acid sequence <SEQ ID 2202; ORF 672.ng>:

g672.pep 1 MRKIRTKICG ITTPEDALYA AHAGADALGL VFYPQSPRAI DIIKAQKIAA 51ALPPFVSVVA LFVNESAQNI RRILAEVPIH IIQFHGDEDD AFCRQFDRPY 101 IKAIRVQTASDIRNAATRFP NAQALLFDAY HPSEYGGTGH RFDWTLLAEY 151 SGKPWVLAGG LTPENVGEAVRITGAEAVDV SGGVEASKGK KDPAKVAAFI 201 ATANRLSR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2203>:

m672.seq 1 ATGAGGAAAA TCCGCACCAA AATCTGCGGC ATCACCACAC CGGAAGACGC 51AGCTGCCGCC GCAGCGGCAG GTGCGGATGC CGTCGGGCTG GTCTTTTTCC 101 AAGGCAGCAGCCGGGCCGTC GATATTGCCC GCGCCAAAAA AATCACCGCC 151 GCACTGCCGC CGTTTGTCAGCGTTGTCGCC CTTTTCGTCA ACGAAAGCGC 201 GCAAAACATC CGCCGCATCC TTGCCGAAGTGCCGATACAC ATCATCCAAT 251 TCCACGGCGA CGAAGACGAC GCATTCTGCC GCCAGTTCCACCGCCCCTAT 301 ATCAAAGCCA TTCGTGTTCA GACGGCATCA GACATCCGAA ACGCCGCCAC351 GCGCTTCCCC GACGCTCAGG CACTGCTGTT CGATGCCTAC CATCCTTCGG 401AATACGGCGG CACCGGAAAC CGCTTCGACT GGACGCTGCT GGCGGAATAT 451 TCGGGCAAACCGTGGGTGCT TGCCGGCGGG CTGACCCCTG AAAACGTCGG 501 CGAAGCCGTC CGCATCACCGGAGCGGAATC GGTCGATGTA TCCGGCGGTG 551 TGGAAGCGTC TAAAGGCAAA AAAGATGCCGCCAAAGTCGC CGCCTTTATC 601 GCAACCGCCA ACCGCCTATC CCGTTAAThis corresponds to the amino acid sequence <SEQ ID 2204; ORF 672>:

m672.pep 1 MRKIRTKICG ITTPEDAAAA AAAGADAVGL VFFQGSSRAV DIARAKKITA 51ALPPFVSVVA LFVNESAQNI RRILAEVPIH IIQFHGDEDD AFCRQFHRPY 101 IKAIRVQTASDIRNAATRFP DAQALLFDAY HPSEYGGTGN RFDWTLLAEY 151 SGKPWVLAGG LTPENVGEAVRITGAESVDV SGGVEASKGK KDAAKVAAFI 201 ATANRLSR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m672/g672 91.3% identity in 208 aa overlap        10        20        30        40        50        60 m672.pepMRKIRTKICGITTPEDAAAAAAAGADAVGLVFFQGSSRAVDIARAKKITAALPPFVSVVA|||||||||||||||||  || ||||:||||:  | ||:|| :|:||:||||||||||| g672MRKIRTKICGITTPEDALYAAHAGADALGLVFYPQSPRAIDIIKAQKIAAALPPFVSVVA        10        20        30        40        50        60        70        80        90       100       110       120 m672.pepLFVNESAQNIRRILAEVPIHIIQFHGDEDDAFCRQFHRPYIKAIRVQTASDIRNAATRFP|||||||||||||||||||||||||||||||||||| ||||||||||||||||||||||| g672LFVNESAQNIRRILAEVPIHIIQFHGDEDDAFCRQFDRPYIKAIRVQTASDIRNAATRFP        70        80        90       100       110       120       130       140       150       160       170       180 m672.pepDAQALLFDAYHPSEYGGTGNRFDWTLLAEYSGKPWVLAGGLTPENVGEAVRITGAESVDV:||||||||||||||||||:||||||||||||||||||||||||||||||||||||:||| g672NAQALLFDAYHPSEYGGTGHRFDWTLLAEYSGKPWVLAGGLTPENVGEAVRITGAEAVDV       130       140       150       160       170       180       190       200       209 m672.pep SGGVEASKGKKDAAKVAAFIATANRLSRX|||||||||||| |||||||||||||||| g672 SGGVEASKGKKDPAKVAAFIATANRLSRX       190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2205>:

a672.seq 1 ATGAGGAAAA TCCGCACCAA AATCTGCGGC ATCACCACAC CGGAAGACGC 51ACTGTATGCC GCCCACGCCG GCGCAGACGC ATTGGGACTG GTTTTTTACC 101 CCCAAAGCCCCCGCGCTGTC GACATCATTA AAGCACAAAA AATCACCGCC 151 GCACTGCCGC CGTTTGTCAGCGTTGTCGCC CTTTTCGTCA ACGAAAGCGC 201 GCAAAACATC CGCCGCATCC TTGCCGAAGTACCGATACAC ATCATCCAAT 251 TCCACGGCGA CGAAGACGAC GCATTCTGCC GCCAGTTCCACCGCCCCTAT 301 ATCAAGGCCA TTCGTGTTCA GACGGCATCA GACATCCGAA ACGCCGCCGA351 CCGCTTCCCC GACGCTCAGG CACTGCTGTT CGATGCCTAC CATCCTTCGG 401AATACGGCGG CACCGGACAC CGCTTCGACT GGACGCTGTT GGCGGAATAT 451 TCGGGCAAACCGTGGGTGCT TGCCGGCGGG CTGACCCCTG AAAACGTCGA 501 CGAAGCCATC CGCATCACCGGAGCGGAAGC GGTCGATGTA TCCGGCGGCG 551 TGGAAGCGTC TAAAGGCAAA AAAGACCCAGCCAAAGTTGC CGCCTTTATC 601 GCAACCGCCA ACCGCCTATC CCGTTAAThis corresponds to the amino acid sequence <SEQ ID 2206; ORF 672.a>:

a672.pep 1 MRKIRTKICG ITTPEDALYA AHAGADALGL VFYPQSPRAV DIIKAQKITA 51ALPPFVSVVA LFVNESAQNI RRILAEVPIH IIQFHGDEDD AFCRQFHRPY 101 IKAIRVQTASDIRNAADRFP DAQALLFDAY HPSEYGGTGH RFDWTLLAEY 151 SGKPWVLAGG LTPENVDEAIRITGAEAVDV SGGVEASKGK KDPAKVAAFI 201 ATANRLSR* m672/a672 91.8% identityin 208 aa overlap        10        20        30        40        50        60 m672.pepMRKIRTKICGITTPEDAAAAAAAGADAVGLVFFQGSSRAVDIARAKKITAALPPFVSVVA|||||||||||||||||  || |||||:||||:  | ||||| :|:|||||||||||||| a672MRKIRTKICGITTPEDALYAAHAGADALGLVFYPQSPRAVDIIKAQKITAALPPFVSVVA        10        20        30        40        50        60        70        80        90       100       110       120 m672.pepLFVNESAQNIRRILAEVPIHIIQFHGDEDDAFCRQFHRPYIKAIRVQTASDIRNAATRFP|||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||| a672LFVNESAQNIRRILAEVPIHIIQFHGDEDDAFCRQFHRPYIKAIRVQTASDIRNAADRFP        70        80        90       100       110       120       130       140       150       160       170       180 m672.pepDAQALLFDAYHPSEYGGTGNRFDWTLLAEYSGKPWVLAGGLTPENVGEAVRITGAESVDV|||||||||||||||||||:|||||||||||||||||||||||||| ||:||||||:||| a672DAQALLFDAYHPSEYGGTGHRFDWTLLAEYSGKPWVLAGGLTPENVDEAIRITGAEAVDV       130       140       150       160       170       180       190       200      209 m672.pep SGGVEASKGKKDAAKVAAFIATANRLSRX|||||||||||| |||||||||||||||| a672 SGGVEASKGKKDPAKVAAFIATANRLSRX       190       200The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2207>:

g673.seq 1 ATGGATATTG AAACCTTCCT TGCAGGGGAA CGCGCCGCCG GCGGATACCG 51TTGCGGCTTC GTGGCGATTG TCGGTCGTCC GAACGTGGGC AAATCAACGC 101 TGATGAACCATCTCATCGGT CAGAAAATCA GTATTACCAG CAAAAAGGCG 151 CAGACGACGC GCAACCGCGTAACGGGGATT TATACCGACG ATACCGCGCA 201 GTTCGTGTTT GTCGATACGC CGGGCTTTCAAACCGACCAC CGCAACGCGC 251 TCAACGACAG GCTGAATCAA AATGTTACCG AGGCGCTCGGCGGTGTGGAT 301 GTGGTGGTTT TCGTCGTGGA GGCGATGCGC CTTACCGATG CCGACCGCGT351 CGTGTTGAAA CAACTGCCCA AGCACACGCC GGTCATTTTA GTGATCAACA 401AAATCGACAA GGACAAGGCG AAAGACCGTT ACGCGCTGGA GGCGTTTGTT 451 GCCCAAGTGCGCGCCGAATT TGAATTTGCG GCGGCGGAGG CGGTCAGTGC 501 GAAACACGGT TTGCGGATTGCCAACCTGTT GGAGCTGCTC AAGCCGTATC 551 TGCCCGAAAG CGTACCGATG TATCCCGAAGACATGGTTAC GGACAAATCG 601 GCGCGTTTTT TGGCGATGGA AATCGTGCGT GAAAAACTCTTCCGCTATTT 651 GGGCGAGGAG CTGCCTTATG CGATGAACGT CGAAGTGGAG CAGTTTGAAG701 AGGGAGACGG TTTGAACCGC ATCTACatcg cCGTTTTGGT CGACAAAGAA 751AGCCAAAAGG CGATTTTGAT CGGTAAAGGC GGGGAGCGTT TGAAAAAAAT 801 TTCCACCGAAGCGCGGCTGG ATATGGAAAA ACTGTTTGAT AACAAAGTAT 851 TTTTGAAGGT CTGGGTCAAAGTCAAATCCG GTTGGGCAGA CGACATTCGC 901 TTCCTGCGCG AGCTGGGTTT GTAGThis corresponds to the amino acid sequence <SEQ ID 2208; ORF 673.ng>:

g673.pep 1 MDIETFLAGE RAAGGYRCGF VAIVGRPNVG KSTLMNHLIG QKISITSKKA 51QTTRNRVTGI YTDDTAQFVF VDTPGFQTDH RNALNDRLNQ NVTEALGGVD 101VVVFVVEAMR LTDADRVVLK QLPKHTPVIL VINKIDKDKA KDRYALEAFV 151 AQVRAEFEFAAAEAVSAKHG LRIANLLELL KPYLPESVPM YPEDMVTDKS 201 ARFLAMEIVR EKLFRYLGEELPYAMNVEVE QFEEGDGLNR IYIAVLVDKE 251 SQKAILIGKG GERLKKISTE ARLDMEKLFDNKVFLKVWVK VKSGWADDIR 301 FLRELGL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2209>:

m673.seq 1 ATGGATATTG AAACCTTCCT TGCAGGGGAA CGCGCCGCCG GCGGATACCG 51TTGCGGCTTC GTAGCGATTG TCGGCCGTCC GAACGTGGGC AAATCAACGC 101 TGATGAACCATCTCATCGGT CAGAAAATCA GTATTACCAG CAAAAAGGCG 151 CAGACGACGC GCAACCGCGTAACGGGGATT TATACCGACG ATACCGCGCA 201 GTTCGTGTTT GTCGATACGC CCGGCTTTCAAACCGACCAC CGCAACGCGC 251 TCAACGACAG GCTGAATCAA AATGTTACCG AGGCGCTCGGCGGCGTGGAT 301 GTGGTGGTTT TCGTCGTGGA GGCGATGCGC TTTACCGATG CCGACCGCGT351 CGTGTTGAAA CAACTGCCCA AGCACACGCC GGTCATTTTA GTGGTCAACA 401AAATCGACAA GGACAAGGCG AAAGACCGTT ACGCGCTGGA GGCGTTTGTT 451 GCCCAAGTGCGCGCCGAATT TGAATTTGCG GCGGCGGAGG CGGTCAGCGC 501 GAAACACGGA TTGCGGATTGCCAACCTGTT GGAGCTGATT AAGCCGTATC 551 TGCCCGAAAG CGTGCCGATG TATCCCGAAGATATGGTTAC GGACAAATCG 601 GCGCGTTTTT TGGCGATGGA AATCGTGCGT GAAAAATTGTTCCGCTATTT 651 GGGCGAGGAA TTGCCTTATG CGATGAACGT CGAAGTGGAG CAGTTTGAAG701 AGGAAGACGG TTTGAACCGC ATCTATATCG CCGTTTTGGT CGATAAGGAA 751AGCCAAAAGG CAATTTTAAT CGGTAAAGGC GGAGAACGTT TGAAGAAAAT 801 TTCCACCGAAGCGCGGTTGG ATATGGAAAA ACTGTTTGAT ACCAAAGTAT 851 TTTTGAAGGT CTGGGTCAAAGTCAAATCCG GTTGGGCGGA CGACATCCGC 901 TTCCTGCGCG AGCTGGGTTT GTAGThis corresponds to the amino acid sequence <SEQ ID 2210; ORF 673>:

m673.pep 1 MDIETFLAGE RAAGGYRCGF VAIVGRPNVG KSTLMNHLIG QKISITSKKA 51QTTRNRVTGI YTDDTAQFVF VDTPGFQTDH RNALNDRLNQ NVTEALGGVD 101VVVFVVEAMR FTDADRVVLK QLPKHTPVIL VVNKIDKDKA KDRYALEAFV 151 AQVRAEFEFAAAEAVSAKHG LRIANLLELI KPYLPESVPM YPEDMVTDKS 201 ARFLAMEIVR EKLFRYLGEELPYAMNVEVE QFEEEDGLNR IYIAVLVDKE 251 SQKAILIGKG GERLKKISTE ARLDMEKLFDTKVFLKVWVK VKSGWADDIR 301 FLRELGL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m673/g673 98.4% identity in 307 aa overlap        10        20        30        40        50        60 m673.pepMDIETFLAGERAAGGYRCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKAQTTRNRVTGI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g673MDIETFLAGERAAGGYRCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKAQTTRNRVTGI        10        20        30        40        50        60        70        80        90       100       110       120 m673.pepYTDDTAQFVFVDTPGFQTDHRNALNDRLNQNVTEALGGVDVVVFVVEAMRFTDADRVVLK||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| g673YTDDTAQFVFVDTPGFQTDHRNALNDRLNQNVTEALGGVDVVVFVVEAMRLTDADRVVLK        70        80        90       100       110       120       130       140       150       160       170       180 m673.pepQLPKHTPVILVVNKIDKDKAKDRYALEAFVAQVRAEFEFAAAEAVSAKHGLRIANLLELI|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||: g673QLPKHTPVILVINKIDKDKAKDRYALEAFVAQVRAEFEFAAAEAVSAKHGLRIANLLELL       130       140       150       160       170       180       190       200       210       220       230       240 m673.pepKPYLPESVPMYPEDMVTDKSARFLAMEIVREKLFRYLGEELPYAMNVEVEQFEEEDGLNR|||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||| g673KPYLPESVPMYPEDMVIDKSARFLAMEIVREKLFRYLGEELPYAMNVEVEQFEEGDGLNR       190       200       210       220       230       240       250       260       270       280       290       300 m673.pepIYIAVLVDKESQKAILIGKGGERLKKISTEARLDMEKLFDTKVFLKVWVKVKSGWADDIR||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||| g673IYIAVLVDKESQKAILIGKGGERLKKISTEARLDMEKLFDNKVFLKVWVKVKSGWADDIR       250       260       270       280       290       300 m673.pepFLRELGLX |||||||| g673 FLRELGLXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2211>:

a673.seq 1 ATGGATATTG AAACCTTCCT TGCAGGGGAA CGCGCCGCCG ACGGATACCG 51TTGCGGCTTC GTAGCGATTG TCGGCCGTCC GAACGTGGGC AAATCAACGC 101 TGATGAATCATCTCATCGGT CAGAAAATCA GTATTACCAG CAAAAAGGCG 151 CAGACGACGC GCAACCGCGTAACGGGGATT TATACCGACG ATACCGCGCA 201 GTTTGTGTTT GTCGATACGC CCGGTTTTCAAACCGACCAC CGCAACGCGC 251 TCAACGACCG TTTGAATCAA AACGTTACCG AGGCACTCGGCGGCGTGGAT 301 GTGGTGGTTT TCGTCGTGGA AGCGATGCGT TTTACCGATG CCGACCGCGT351 CGTGTTGAAA CAACTGCCCA AGCACACGCC GGTCATTTTA GTGGTCAACA 401AAATCGATAA GGACAAGGCG AAAGACCGTT ACGCGCTGGA GGCGTTTGTT 451 GCCCAGGTGCGCGCCGAATT TGAATTTGCG GCGGCGGAGG CGGTCAGCGC 501 GAAACACGGA TTGCGGATTGCCAACCTGTT GGAGCTGATT AAGCCGTATC 551 TGCCCGAAAG CGTGCCGATG TATCCCGAAGATATGGTTAC GGACAAATCG 601 GCGCGTTTTT TAGCGATGGA AATCGTGCGT GAAAAATTGTTCCGCTATTT 651 GGGCGAGGAA TTGCCTTATG CGATGAACGT CGAAGTGGAG CAGTTTGAAG701 AGGAAGACGG TTTGAACCGC ATCTATATCG CCGTTTTGGT CGATAAGGAA 751AGCCAAAAGG CGATTTTAAT CGGCAAAGGC GGGGAGCGTT TGAAGAAAAT 801 TTCCACCGAAGCGCGGTTGG ATATGGAAAA ACTGTTTGAT ACCAAAGTAT 851 TTTTGAAGGT CTGGGTCAAAGTCAAATCCG GTTGGGCGGA CGACATCCGC 901 TTCCTGCGCG AGCTGGGTTT GTAGThis corresponds to the amino acid sequence <SEQ ID 2212; ORF 673.a>:

a673.pep 1 MDIETFLAGE RAADGYRCGF VAIVGRPNVG KSTLMNHLIG QKISITSKKA 51QTTRNRVTGI YTDDTAQFVF VDTPGFQTDH RNALNDRLNQ NVTEALGGVD 101VVVFVVEAMR FTDADRVVLK QLPKHTPVIL VVNKIDKDKA KDRYALEAFV 151 AQVRAEFEFAAAEAVSAKHG LRIANLLELI KPYLPESVPM YPEDMVTDKS 201 ARFLAMEIVR EKLFRYLGEELPYAMNVEVE QFEEEDGLNR IYIAVLVDKE 251 SQKAILIGKG GERLKKISTE ARLDMEKLFDTKVFLKVWVK VKSGWADDIR 301 FLRELGL* m673/a673 99.7% identity in 307 aaoverlap         10        20        30        40        50        60m673.pep MDIETFLAGERAAGGYRCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKAQTTRNRVTGI||||||||||||| |||||||||||||||||||||||||||||||||||||||||||||| a673MDIETFLAGERAADGYRCGFVAIVGRPNVGKSTLMNHLIGQKISITSKKAQTTRNRVIGI        10        20        30        40        50        60        70        80        90       100       110       120 m673.pepYTDDTAQFVFVDTPGFQTDHRNALNDRLNQNVTEALGGVDVVVFVVEAMRFTDADRVVLK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a673YTDDTAQFVFVDTPGFQTDHRNALNDRLNQNVTEALGGVDVVVFVVEAMRFTDADRVVLK        70        80        90       100       110       120       130       140       150       160       170       180 m673.pepQLPKHTPVILVVNKIDKDKAKDRYALEAFVAQVRAEFEFAAAEAVSAKHGLRIANLLELI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a673QLPKHTPVILVVNKIDKDKAKDRYALEAFVAQVRAEFEFAAAEAVSAKHGLRIANLLELI       130       140       150       160       170       180       190       200       210       220       230       240 m673.pepKPYLPESVPMYPEDMVTDKSARFLAMEIVREKLFRYLGEELPYAMNVEVEQFEEEDGLNR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a673KPYLPESVPMYPEDMVIDKSARFLAMEIVREKLFRYLGEELPYAMNVEVEQFEEEDGLNR       190       200       210       220       230       240       250       260       270       280       290       300 m673.pepIYIAVLVDKESQKAILIGKGGERLKKISTEARLDMEKLFDTKVFLKVWVKVKSGWADDIR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a673IYIAVLVDKESQKAILIGKGGERLKKISTEARLDMEKLFDTKVFLKVWVKVKSGWADDIR       250       260       270       280       290       300 m673.pepFLRELGLX |||||||| a673 FLRELGLXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2213>:

g674.seq 1 ATGAAAACAG CCCGCCGCCG TTCCCGCGAG CTTGCCGTAC AAGCCGTTTA 51CCAATCCCTT ATCAACCGCA CCGCCGCGCC CGAAATTGCT AAAAACATCC 101 GCGAAATGTCCGACTTTGCC AAAGCGGACG AAGAATTGTT CAACAAACTC 151 TTCTTCGGCA CACAAACCAATGCAGCGGAC TACATCCAAA AAATCCGCCC 201 GCTGCTCGAC AGGGACGAAA AAGACCTCAACCCCATCGAA CGCGCCGTTT 251 TGCTGACCGC CTGCCACGAG CTTTCCGCTA TGCCCGAAACGCCCTACCCC 301 GTCATTATCA ACGAAGCCAT CGAAGTTACC AAAACCTTCG GCGGCACGGA351 CGGGCACAAA TTCGTCAACG GCATCCTCGA CAAACTCGCC GCCCAAATCC 401GCCCAGACGA GCCCAAACGC CGTTGAThis corresponds to the amino acid sequence <SEQ ID 2214; ORF 674.ng>:

g674.pep 1 MKTARRRSRE LAVQAVYQSL INRTAAPEIA KNIREMSDFA KADEELFNKL 51FFGTQTNAAD YIQKIRPLLD RDEKDLNPIE RAVLLTACHE LSAMPETPYP 101 VIINEAIEVTKTFGGTDGHK FVNGILDKLA AQIRPDEPKR R*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2215>:

m674.seq 1 ATGAAAACAG CCCGCCGCCG TTCCCGCGAG CTTGCCGTAC AAGCCGTTTA 51CCAATCCCTT ATCAACCGCA CCGCCGCGCC CGAAATTGCT AAAAACATCC 101 GCGAAATGTCCGACTTTGCC AAGGCAGACG AAGAATTGTT CAACAAACTT 151 TTCTTCGGCA CGCAAACCAATGCGGCAGAG TATATCCGAC AAATCCGCCC 201 GCTACTTGAC AGGGACGAAA AAGACCTCAACCCCATCGAA CGCGCCGTTT 251 TGCTGACCGC CTGCCACGAG CTGTCCGCCA TGCCCGAAACGCCCTACCCC 301 GTCATTATCA ACGAAGCCAT CGAAGTTACC AAAACCTTCG GCGGCACGGA351 CGGGCACAAA TTCGTCAACG GCATCCTCGA CAAACTCGCC GCCCAAATCC 401GCCCCGACGA GCCCAAACGC CGTTGAThis corresponds to the amino acid sequence <SEQ ID 2216; ORF 674>:

m674.pep 1 MKTARRRSRE LAVQAVYQSL INRTAAPEIA KNIREMSDFA KADEELFNKL 51FFGTQTNAAE YIRQIRPLLD RDEKDLNPIE RAVLLTACHE LSAMPETPYP 101 VIINEAIEVTKTFGGTDGHK FVNGILDKLA AQIRPDEPKR R*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m674/g674 97.9% identity in 141 aa overlap        10        20        30        40        50        60 m674.pepMKTARRRSRELAVQAVYQSLINRTAAPEIAKNIREMSDFAKADEELFNKLFFGTQTNAAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: g674MKTARRRSRELAVQAVYQSLINRTAAPEIAKNIREMSDFAKADEELFNKLFFGTQTNAAD        10        20        30        40        50        60        70        80        90       100       110       120 m674.pepYIRQIRPLLDRDEKDLNPIERAVLLTACHELSAMPETPYPVIINEAIEVTKTFGGTDGHK||::|||||||||||||||||||||||||||||||||||||||||||||||||||||||| g674YIQKIRPLLDRDEKDLNPIERAVLLTACHELSAMPETPYPVIINEAIEVIKTFGGIDGHK        70        80        90       100       110       120       130       140 m674.pep FVNGILDKLAAQIRPDEPKRRX|||||||||||||||||||||| g674 FVNGILDKLAAQIRPDEPKRRX        130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2217>:

a674.seq 1 ATGAAAACAG CCCGCCGCCG TTCCCGCGAG CTTGCCGTAC AAGCCGTTTA 51CCAATCCCTT ATCAACCGCA CCGCCGCGCC CGAGATTGCT AAAAACATCC 101 GCGAAATGCCCGACTTTGCC AAGGCAGACG AAGAATTGTT CAACAAACTT 151 TTCTTCGGCA CGCAAACCAATGCGGCAGAG TACATCCGAC AAATCCGCCC 201 CCTGCTCGAC CGCGACGAAA AAGACCTCAACCCCATCGAA CGCGCCGTCC 251 TGCTGACCGC CTGCCACGAG CTGTCCGCCA TGCCCGAAACGCCCTACCCC 301 GTCATCATCA ACGAAGCCAT CGAAGTAACC AAAACCTTCG GCGGCACGGA351 CGGGCACAAA TTCGTCAACG GCATCCTCGA CAAACTCGCC GCCCAAATCC 401GTCCCGACGA GCCCAAACGC CGTTGAThis corresponds to the amino acid sequence <SEQ ID 2218; ORF 674.a>:

a674.pep 1 MKTARRRSRE LAVQAVYQSL INRTAAPEIA KNIREMPDFA KADEELFNKL 51FFGTQTNAAE YIRQIRPLLD RDEKDLNPIE RAVLLTACHE LSAMPETPYP 101 VIINEAIEVTKTFGGTDGHK FVNGILDKLA AQIRPDEPKR R* m674/a674 99.3% identity in 141 aaoverlap         10        20        30        40        50        60m674.pep MKTARRRSRELAVQAVYQSLINRTAAPEIAKNIREMSDFAKADEELFNKLFFGTQTNAAE|||||||||||||||||||||||||||||||||||| ||||||||||||||||||||||| a674MKTARRRSRELAVQAVYQSLINRTAAPEIAKNIREMPDFAKADEELFNKLFFGTQTNAAE        10        20        30        40        50        60        70        80        90       100       110       120 m674.pepYIRQIRPLLDRDEKDLNPIERAVLLTACHELSAMPETPYPVIINEAIEVTKTFGGTDGHK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a674YIRQIRPLLDRDEKDLNPIERAVLLTACHELSAMPETPYPVIINEAIEVIKTFGGIDGHK        70        80        90       100       110       120       130       140 m674.pep FVNGILDKLAAQIRPDEPKRRX|||||||||||||||||||||| a674 FVNGILDKLAAQIRPDEPKRRX        130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2219>:

g675.seq 1 ATGAACACCA TCGCCCCcaa cctcgacgGC AAACACCTCC GCATCGGCAT 51CGTACAGGCA CGCTTCACCA ACGAAATCGG CAGCCAAATG CTCAAAGTCT 101 GCTGCCGCACCCTCCAAGAA TTGGGCGTAG CAGACGAAAa catcaccgtc 151 gCCACCGTAC CCGGCGCGCTTGAAATCCCC ATCGCGCTGA TGAACTTTGC 201 CTCTTCCGAA AAATTTGACG CACTGATTGCCATCGGCGTC GTCATCCGTG 251 GCGAAACCTA CCATTTCGAG CTGGTTGCCA ACGAATCCGGCGCAGGGATC 301 GGCCGCGTCG CACTCGACTA CAACATCCCG ATTGCCAACG CCGTCCTGAC351 CACCGAAAAC GACGCGCAGG CAATTGAACG GATTGGAGAA AAAGCCTCGG 401ATGCCGCCAA AGTCGCCGTA GAATGCGCCA ACCTCGTCAA CCTTCTGCTC 451 GAAGAACAGTTTGAAGACGA AGAATAAThis corresponds to the amino acid sequence <SEQ ID 2220; ORF 675.ng>:

g675.pep 1 MNTIAPNLDG KHLRIGIVQA RFTNEIGSQM LKVCCRTLQE LGVADENITV 51ATVPGALEIP IALMNFASSE KFDALIAIGV VIRGETYHFE LVANESGAGI 101 GRVALDYNIPIANAVLTTEN DAQAIERIGE KASDAAKVAV ECANLVNLLL 151 EEQFEDEE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2221>:

m675.seq 1 ATGAACACCA TCGCCCCCAA CCTCGACGGC AAACACCTCC GCATCGGCAT 51CGTACAGGCA CGCTTCACCA ACGAAATCGG CAGCGAAATG CTCAAAGTCT 101 GCTGCCGCACCCTCCAAGAA TTGGGCGTGG CAGACGAAAA CATTACCGTC 151 GCCACCGTAC CCGGCGCGCTTGAAATCCCC ATCGCGCTGA TGAACTTTGC 201 CTCTTCCGAA AAGTTTGACG CACTGATTGCCATCGGCGTC GTCATCCGTG 251 GCGAAACCTA CCATTTCGAG CTGGTTTCCA ACGAATCCGGAGCAGGCGTC 301 AGCCGCGTCG CACTCGACTA CAATATCCCG ATTGCCAATG CCGTCCTAAC351 CACCGAAAAC GACGCGCAGG CAATCGAACG GATTGAAGAA AAAGCCTCGG 401ATGCCGCCAA AGTCGCCGTC GAATGCGCCA ACCTCGTCAA CCTGCTGCTC 451 GAAGAACAGTTTGAAGACGA AGAATAAThis corresponds to the amino acid sequence <SEQ ID 2222; ORF 675>:

m675.pep 1 MNTIAPNLDG KHLRIGIVQA RFTNEIGSEM LKVCCRTLQE LGVADENITV 51ATVPGALEIP IALMNFASSE KFDALIAIGV VIRGETYHFE LVSNESGAGV 101 SRVALDYNIPIANAVLTTEN DAQAIERIEE KASDAAKVAV ECANLVNLLL 151 EEQFEDEE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m675/g675 96.8% identity in 158 aa overlap        10        20        30        40        50        60 m675.pepMNTIAPNLDGKHLRIGIVQARFTNEIGSEMLKVCCRTLQELGVADENITVATVPGALEIP||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||| g675MNTIAPNLDGKHLRIGIVQARFTNEIGSQMLKVCCRTLQELGVADENITVATVPGALEIP        10        20        30        40        50        60        70        80        90       100       110       120 m675.pepIALMNFASSEKFDALIAIGVVIRGETYHFELVSNESGAGVSRVALDYNIPIANAVLTTEN||||||||||||||||||||||||||||||||:||||||::||||||||||||||||||| g675IALMNFASSEKFDALIAIGVVIRGETYHFELVANESGAGIGRVALDYNIPIANAVLTTEN        70        80        90       100       110       120       130       140       150      159 m675.pepDAQAIERIEEKASDAAKVAVECANLVNLLLEEQFEDEEX|||||||| |||||||||||||||||||||||||||||| g675DAQAIERIGEKASDAAKVAVECANLVNLLLEEQFEDEEX        130       140       150The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2223>:

a675.seq 1 ATGAACACCA TCGCCCCCAA CCTCGACGGC AAACACCTCC GCATCGGCAT 51CGTACAGGCA CGCTTCACCA ACGAAATCGG CAGCGAAATG CTCAAAGTCT 101 GCTGCCGCACCCTCCAAGAA TTGGGCGTGG CAGACGAAAA CATTACCGTC 151 GCCACCGTAC CCGGCGCGCTTGAAATCCCC ATCGCGCTGA TGAACTTTGC 201 CTCTTCTGAA AAATTTGACG CACTGATTGCCATCGGCGTC GTTATCCGTG 251 GCGAAACCTA CCATTTCGAG CTGGTTTCCA ACGAATCCGGAGCAGGGGTC 301 AGCCGCGTCG CACTCGACTA CAACATCCCG ATTGCCAATG CCGTCCTGAC351 CACGGAAAAC GACGCACAGG CAATCGAACG GATTGAAGAA AAAGCCTCGG 401ATGCCGCCAA AGTCGCCGTA GAATGCGCCA ACCTCGTCAA CCTCCTGCTC 451 GAAGAACAGTTTGAAGACGA AGAATAAThis corresponds to the amino acid sequence <SEQ ID 2224; ORF 675.a>:

a675.pep 1 MNTIAPNLDG KHLRIGIVQA RFTNEIGSEM LKVCCRTLQE LGVADENITV 51ATVPGALEIP IALMNFASSE KFDALIAIGV VIRGETYHFE LVSNESGAGV 101 SRVALDYNIPIANAVLTTEN DAQAIERIEE KASDAAKVAV ECANLVNLLL 151 EEQFEDEE* m675/a675100.0% identity in 158 aa overlap        10        20        30        40        50        60 m675.pepMNTIAPNLDGKHLRIGIVQARFTNEIGSEMLKVCCRTLQELGVADENITVATVPGALEIP||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a675MNTIAPNLDGKHLRIGIVQARFTNEIGSEMLKVCCRTLQELGVADENITVATVPGALEIP        10        20        30        40        50        60        70        80        90       100       110       120 m675.pepIALMNFASSEKFDALIAIGVVIRGETYHFELVSNESGAGVSRVALDYNIPIANAVLTTEN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a675IALMNFASSEKFDALIAIGVVIRGETYHFELVSNESGAGVSRVALDYNIPIANAVLTTEN        70        80        90       100       110       120       130       140       150      159 m675.pepDAQAIERIEEKASDAAKVAVECANLVNLLLEEQFEDEEX||||||||||||||||||||||||||||||||||||||| a675DAQAIERIEEKASDAAKVAVECANLVNLLLEEQFEDEEX        130       140       150The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2225>:

g677.seq 1 ATGCCGCAGA TTTTGGTGCG GATTTTCCTC ATTCGGTATT CCTTTATTtg 51ggAAACGGTG CGCTTGTGCC GTTTCAGACG GCATTCCCGA TCAGTCGATT 101 TTGATGTATTCGACAGAAAG GATTTCAATT TCCTCACGGC CTTCCGGCGT 151 GTTCAAAACC ACTTCGTCGCCTTCGCGCGC TTTAATCAGG CAACGCGCCA 201 ACGGCGAAAT CCAAGAAATT TTGTTTTGCGCGGTATCGAT TTCATCGACG 251 CCGACGATTT TGACGGTTTG CTCGCGCCCG TCGCCGCGCAACAGACCGAC 301 GGTCGCGCCG AAAAATACTT GGTCGGTCGC TTCGCGCAAT TCGGGATCGA351 CGACGACGGC AGCCTCCAAA CGTTTGGTCA GGAAACGGAT GCGGCGGTCG 401ATTTCGCGCA TACGGCGTTT GCCGTAAAGA TAGTCGCCGT TTTCGCTGCG 451 GTCGCCGTTGCCTGCCGCCC AGTTGACGAT TTGGACGATT TCGGGGCGTT 501 CTTTATTGAC CAGTTGATAAAGCTCGTCTT TCAATGCCTG CCATCCGGCG 551 GGCGTAATGT AGTTTTTGGT TTCGGTACTCATATTGTGTG CGGATGAThis corresponds to the amino acid sequence <SEQ ID 2226; ORF 677.ng>:

g677.pep 1 MPQILVRIFL IRYSFIWETV RLCRFRRHSR SVDFDVFDRK DFNFLTAFRR 51VQNHFVAFAR FNQATRQRRN PRNFVLRGID FIDADDFDGL LAPVAAQQTD 101 GRAEKYLVGRFAQFGIDDDG SLQTFGQETD AAVDFAHTAF AVKIVAVFAA 151 VAVACRPVDD LDDFGAFFIDQLIKLVFQCL PSGGRNVVFG FGTHIVCG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2227>:

m677.seq 1 ATGCCGCAGA TTTTGGTGCG GATTTTCCTC ATTCGGTATT CCTTTATTTG 51GGAAACGGCG CGCTTTTGCC GTTTCAGACG GCATTCCCGA TCAGTCGATT 101 TTGATGTATTCGACAGAAAG GATTTCAATT TCCTCACGCC CTTCCGGCGT 151 GTTCAAAACC ACTTCGTCGCCTTCGCGCGC TTTAATCAGA CAACGAGCCA 201 GCGGCGAAAT CCAAGAAATT TTGTTTTGCGCGGTATCGAT TTCATCGATG 251 CCGACGATTT TGACGGTTTG CTCGCGCCCG TCGTCGCGCAACAGTCCGAC 301 CGTCGCGCCG AAAAACACTT GGTCGGTCGC TTCGCGCAAT TCGGGATCGA351 CGACGACGGC AGCCTCCAAA CGTTTGGTCA GGAAACGGAT GCGGCGGTCG 401ATTTCGCGCA TACGGCGTTT GCCGTAAAGA TAGTCGCCGT TTTCGCTGCG 451 GTCGCCGTTGCCTGCCGCCC AGTTGACGAT TTGGACGATT TCGGGGCGTT 501 CTTTGTTGAC CAGTTGATAAAGCTCGTCTT TCAATGCCTG CCATCCGGCG 551 GGCGTAATGT AGTTTTTGGT TTCGGTACTCATATTGTGTG CGGATGAThis corresponds to the amino acid sequence <SEQ ID 2228; ORF 677>:

m677.pep 1 MPQILVRIFL IRYSFIWETA RFCRFRRHSR SVDFDVFDRK DFNFLTPFRR 51VQNHFVAFAR FNQTTSQRRN PRNFVLRGID FIDADDFDGL LAPVVAQQSD 101 RRAEKHLVGRFAQFGIDDDG SLQTFGQETD AAVDFAHTAF AVKIVAVFAA 151 VAVACRPVDD LDDFGAFFVDQLIKLVFQCL PSGGRNVVFG FGTHIVCG*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m677/g677 94.9% identity in 198 aa overlap        10        20        30        40        50        60 m677.pepMPQILVRIFLIRYSFIWETARFCRFRRHSRSVDFDVFDRKDFNFLTPFRRVQNHFVAFAR|||||||||||||||||||:|:|||||||||||||||||||||||| ||||||||||||| g677MPQILVRIFLIRYSFIWETVRLCRFRRHSRSVDFDVFDRKDFNFLTAFRRVQNHFVAFAR        10        20        30        40        50        60        70        80        90       100       110       120 m677.pepFNQTTSQRRNPRNFVLRGIDFIDADDFDGLLAPVVAQQSDRRAEKHLVGRFAQFGIDDDG|||:| ||||||||||||||||||||||||||||:|||:| ||||:|||||||||||||| g677FNQATRQRRNPRNFVLRGIDFIDADDFDGLLAPVAAQQTDGRAEKYLVGRFAQFGIDDDG        70        80        90       100       110       120       130       140       150       160       170       180 m677.pepSLQTFGQETDAAVDFAHTAFAVKIVAVFAAVAVACRPVDDLDDFGAFFVDQLIKLVFQCL||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||| g677SLQTFGQETDAAVDFAHTAFAVKIVAVFAAVAVACRPVDDLDDFGAFFIDQLIKLVFQCL       130       140       150       160       170       180       190      199 m677.pep PSGGRNVVFGFGTHIVCGX |||||||||||||||||||g677 PSGGRNVVFGFGTHIVCGX        190The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2229>:

a677.seq 1 ATGCCGCAGA TTTTGGTGCG GATTTTCCTC ATTCGGTATT CCTTTATTTG 51GGAAACGGCG CGTTTGTGCC GTTTCAGACG GCATTCCCGA TCAGTCGATT 101 TTGATGTATTCGACAGAAAG GATTTCAATT TCCTCACGCC CTTCCGGCGT 151 GTTTAAAACC ACTTCGTCGCCTTCACGCGC TTTAATCAGA CAACGAGCCA 201 GCGGCGAAAT CCAAGAAATT TTGTTTTGCGCGGTATCGAT TTCATCGATG 251 CCGACGATTT TGACGGTTTG CTCGCGCCCG TCGCCGCGCAACAGACCGAC 301 GGTCGCGCCG AAAAACACTT GGTCGGTCGC TTCGCGCAAT TCGGGATCAA351 CGACGACGGC GGCTTCCAAA CGCTTGGTCA GGAAACGGAT GCGGCGGTCG 401ATTTCGCGCA TACGGCGTTT GCCGTAAAGG TAGTCGCCGT TTTCGCTGCG 451 GTCGCCGTTGCCTGCCGCCC AGTTGACGAT TTGGACGATT TCGGGGCGTT 501 CTTTATTAAC CAGTTGATAAAGCTCGTCTT TCAATGCCTG CCATCCGGCG 551 GGCGTAATGT AGTTTTTGGT TTCGGTACTCATATTGTGTG CGGATGAThis corresponds to the amino acid sequence <SEQ ID 2230; ORF 677.a>:

a677.pep 1 MPQILVRIFL IRYSFIWETA RLCRFRRHSR SVDFDVFDRK DFNFLTPFRR 51V*NHFVAFTR FNQTTSQRRN PRNFVLRGID FIDADDFDGL LAPVAAQQTD 101 GRAEKHLVGRFAQFGINDDG GFQTLGQETD AAVDFAHTAF AVKVVAVFAA 151 VAVACRPVDD LDDFGAFFINQLIKLVFQCL PSGGRNVVFG FGTHIVCG* m677/a677 93.4% identity in 198 aaoverlap         10        20        30        40        50        60m677.pep MPQILVRIFLIRYSFIWETARFCRFRRHSRSVDFDVFDRKDFNFLTPFRRVQNHFVAFAR|||||||||||||||||||||:||||||||||||||||||||||||||||| ||||||:| a677MPQILVRIFLIRYSFIWETARLCRFRRHSRSVDFDVFDRKDFNFLTPFRRVXNHFVAFTR        10        20        30        40        50        60        70        80        90       100       110       120 m677.pepFNQTTSQRRNPRNFVLRGIDFIDADDFDGLLAPVVAQQSDRRAEKHLVGRFAQFGIDDDG||||||||||||||||||||||||||||||||||:|||:| |||||||||||||||:||| a677FNQTTSQRRNPRNFVLRGIDFIDADDFDGLLAPVAAQQTDGRAEKHLVGRFAQFGINDDG        70        80        90       100       110       120       130       140       150       160       170       180 m677.pepSLQTFGQETDAAVDFAHTAFAVKIVAVFAAVAVACRPVDDLDDFGAFFVDQLIKLVFQCL::||:||||||||||||||||||:||||||||||||||||||||||||::|||||||||| a677GFQTLGQETDAAVDFAHTAFAVKVVAVFAAVAVACRPVDDLDDFGAFFINQLIKLVFQCL       130       140       150       160       170       180       190      199 m677.pep PSGGRNVVFGFGTHIVCGX |||||||||||||||||||a677 PSGGRNVVFGFGTHIVCGX        190The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2231>:

g678.seq 1 ATGAATAGCC TCCCCATTGC CGACCTCCTC GCCTccgCCG TCATCGCCGC 51CTGCATCGTC ATTTCCACGA TGCGCGGCGT GATTGCGGAA GCAggttcGA 101 TGGTgGCATGggtggTTTcc tTCTTTTttg ccAAACTCTt tGCCGCACcc 151 ttcgccgACC TCGCCTTTGcctCGTTCCAA ccccgccTGT TTGCAttggc 201 tCTGTCATTC ATTTCCCTGT TCGTCATTGCCTGTCTGATC CAGAAAATGC 251 TCCGTTCGCT GCTGACCGGC GCAGTTTCGG CGGTCGGTCTGGGCTTTGCC 301 AACCGCATTT TGGGCGGTGT ATTCGGTGCA TTGAAAGGCG TTTTGATTGT351 TACCCTGCTG ATCATGCTTG CTTCAAAAAC CGACCTGCCC GATACCGAAG 401AATGGCAACA GTCCTATACC GTACCGTTTT TCGTATCGCT TTCCGAAGCG 451 GTGTTAAACCatacggaCAA CGCacccgaa tCCCtcgacg acgactaaThis corresponds to the amino acid sequence <SEQ ID 2232; ORF 678.ng>:

g678.pep 1 MNSLPIADLL ASAVIAACIV ISTMRGVIAE AGSMVAWVVS FFFAKLFAAP 51FADLAFASFQ PRLFALALSF ISLFVIACLI QKMLRSLLTG AVSAVGLGFA 101NRILGGVFGA LKGVLIVTLL IMLASKTDLP DTEEWQQSYT VPFFVSLSEA 151 VLNHTDNAPESLDDD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2233>:

m678.seq 1 ATGAATAGCC TCCCCATTGC CGACCTCCTC GTCTCCGCCG TCATCGCCGC 51CTGCATCGTG CTATCCGCGA TGCGCGGCGT GATTGCGGAG GCAGGCTCAA 101 TGGCGGCATGGGTGGTTTCC TTCTTTTTCG CCAAACTCTT TGCCGCCTCC 151 TTCGCCGACC TCGCCTTTGCCTCGTTCCAA CCCCGCCTGT TTGCATTGGC 201 TCTGTCGTTC ATTTCCCTGT TCGTCATTGCCTGTCTGATC CAGAAAATGC 251 TCCGTTCGCT GCTGACCAGC GCAGTTTCGG CGGTCGGTTTGGGCTTTGCC 301 AACCGCATTT TGGGCGGCGT ATTCGGTGCA TTGAAAGGCG TTTTGATTGT351 TACCCTGCTG GTCATGCTTG CTTCAAAAAC CGACCTGCCC GATACCGAAG 401AATGGCGGCA ATCTTACACA CTGCCGTTTT TCGTATCGCT TTCCGAAGCC 451 GTGTTGAACCATAGCGGCGG CACGGCGGAA ACTCCGGAAG ACGATTGAThis corresponds to the amino acid sequence <SEQ ID 2234; ORF 678>:

m678.pep 1 MNSLPIADLL VSAVIAACIV LSAMRGVIAE AGSMAAWVVS FFFAKLFAAS 51FADLAFASFQ PRLFALALSF ISLFVIACLI QKMLRSLLTS AVSAVGLGFA 101NRILGGVFGA LKGVLIVTLL VMLASKTDLP DTEEWRQSYT LPFFVSLSEA 151 VLNHSGGTAETPEDD*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m678/g678 89.7% identity in 165 aa overlap        10        20        30        40        50        60 m678.pepMNSLPIADLLVSAVIAACIVLSAMRGVIAEAGSMAAWVVSFFFAKLFAASFADLAFASFQ||||||||||:|||||||||:|:|||||||||||:|||||||||||||| |||||||||| g678MNSLPIADLLASAVIAACIVISTMRGVIAEAGSMVAWVVSFFFAKLFAAPFADLAFASFQ        10        20        30        40        50        60        70        80        90       100       110       120 m678.pepPRLFALALSFISLFVIACLIQKMLRSLLTSAVSAVGLGFANRILGGVFGALKGVLIVTLL|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| g678PRLFALALSFISLFVIACLIQKMLRSLLTGAVSAVGLGFANRILGGVFGALKGVLIVTLL        70        80        90       100       110       120       130       140       150       160 m678.pepVMLASKTDLPDTEEWRQSYTLPFFVSLSEAVLNHSGGTAETPEDDX:||||||||||||||:||||:|||||||||||||: :: |: :||| g678IMLASKTDLPDTEEWQQSYTVPFFVSLSEAVLNHTDNAPESLDDDX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2235>:

a678.seq 1 ATGAATAACC TCCCCGTTGC CGACCTCCTC GTCTCCGCCA TCATCGCCGC 51CTGCATCGTG CTATCCGCGA TGCGCGGCGT GATTGCGGAG GCTGGCTCAA 101 TGGCGGCATGGGTGGTTGCC TTTTTTTTCG CCAAACTCTT TGCCGCACCC 151 TTCGCCGACA TCGCCTTTGCATCGTTCCAA CCCCGCCTGT TTGCATTGGC 201 TCTGTCGTTC ATTTCCCTAT TCGTCATTGCCTGTCTGATC CAGAAAATAC 251 TCCGCTCGCT GCTGACCGGG GCAGTTTCGG CGGTCGGTTTGGGCTTTGCC 301 AACCGCATTT TGGGCGGCGT ATTCGGTGCA TTGAAAGGCA TTTTGATTAT351 TACCCTGCTG GTCATGCTCG CTTCAAAAAC CGACCTGCCC GATACCGAAG 401AATGGCGGCA ATCTTACACA CTGCCGTTTT TCGTATCGCT TTCCGAAGCC 451 GTGTTGAACCATAGCGGCGG CACGGCGGAA ACTCCGGAAG ACGATTGAThis corresponds to the amino acid sequence <SEQ ID 2236; ORF 678.a>:

a678.pep 1 MNNLPVADLL VSAIIAACIV LSAMRGVIAE AGSMAAWVVA FFFAKLFAAP 51FADIAFASFQ PRLFALALSF ISLFVIACLI QKILRSLLTG AVSAVGLGFA 101NRILGGVFGA LKGILIITLL VMLASKTDLP DTEEWRQSYT LPFFVSLSEA 151 VLNHSGGTAETPEDD* m678/a678 93.9% identity in 165 aa overlap        10        20        30        40        50        60 m678.pepMNSLPIADLLVSAVIAACIVLSAMRGVIAEAGSMAAWVVSFFFAKLFAASFADLAFASFQ||:||:|||||||:|||||||||||||||||||||||||:||||||||| |||:|||||| a678MNNLPVADLLVSAIIAACIVLSAMRGVIAEAGSMAAWVVAFFFAKLFAAPFADIAFASFQ        10        20        30        40        50        60        70        80        90       100       110       120 m678.pepPRLFALALSFISLFVIACLIQKMLRSLLTSAVSAVGLGFANRILGGVFGALKGVLIVTLL||||||||||||||||||||||:||||||:|||||||||||||||||||||||:||:||| a678PRLFALALSFISLFVIACLIQKILRSLLTGAVSAVGLGFANRILGGVFGALKGILIITLL        70        80        90       100       110       120       130       140       150       160 m678.pepVMLASKTDLPDTEEWRQSYTLPFFVSLSEAVLNHSGGTAETPEDDX|||||||||||||||||||||||||||||||||||||||||||||| a678VMLASKTDLPDTEEWRQSYTLPFFVSLSEAVLNHSGGTAETPEDDX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2237>:

g680.seq 1 ATGACGAAGG GCAGTTCGGC GATGTCCAGC CCACGCGCGG CGATATCGGT 51GGCGACGAGG ACGCGCAGGC TGCCGTCTTT GAAGGCGTTG AGTGTTTCGA 101 GCCTGCTTTGTTGGGAACGG TCGCCGTGTA TCGCCTGTGC GGACAGGTTG 151 CGGCGCACCA GTTCGCGCGTTACGCGGTCG ACGCTTTGTT TGGTtttgCA 201 AAAGACGATA ACTTGGTTCA TATGCAGATCGACAATCAGC CGTTCGAGCA 251 GGTTGCGCTT TTGGAAGGTA TCGACGGCGA TGATGTgttgttcGACGTTG 301 GCGTTGGTGG TGTTTTGGGC GGCAACCTCG ACGGTTTCGG GCGCGTTCAT351 GAAGTCTTGC GCCAGTTTGC GTATCGGTGC GGAGAAGGTG GCGGAAAAGA 401GCAGGGTTTG GCGTTGGCGG GGCAGCATCT GCATGATTTT GCGGATGTCG 451 TCGATAAACCCCATATCCAA CATGCGGTCT GCTTCGTCCA GAACGACGAT 501 TTCGGCTTTG TTTAAACTGATGTTTTTCTG TTTCACATGG TCGAGCAGCC 551 GTCCGACGGT GGCGACGACT ATTTCGCAGCCGGCACGCAG GTCGGCGGTT 601 TGTTTGTCCA TGTTGACACC GCCGAAGAGG ACGGTATGCCGCAGCGGCAG 651 GTTTTTAATg tagThis corresponds to the amino acid sequence <SEQ ID 2238; ORF 680.ng>:

g680.pep 1 MTKGSSAMSS PRAAISVATR TRRLPSLKAL SVSSLLCWER SPCIACADRL 51RRTSSRVTRS TLCLVLQKTI TWFICRSTIS RSSRLRFWKV STAMMCCSTL 101 ALVVFWAATSTVSGAFMKSC ASLRIGAEKV AEKSRVWRWR GSICMILRMS 151 SINPISNMRS ASSRTTISALFKLMFFCFTW SSSRPTVATT ISQPARRSAV 201 CLSMLTPPKR TVCRSGRFLM *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2239>:

m680.seq 1 ATGACGAAGG GCAGTTCGGC AATGTCCAGC CCGCGCGCGG CGATGTCGGT 51GGCGACGAGG ACGCGCAGGT TGCCGTCTTT GAAGGCGTTG AGTGTTTCGA 101 GCCGGCTTTGTTGGGAACGG TCGCCGTGTA TCGCCTGTGC GGACAGGTTG 151 CGGCGCACCA GTTCGCGCGTTACGCGGTCG ACGCTTTGTT TGGTTTTGCA 201 GAACACGATG ACCTGGTTCA TATGCAAATCGACAATCAGC CGTTCGAGCA 251 GGTTGCGCTT CTGAATGGTA TCGACGGCGA TGATGTGCTGCTCGACGTTG 301 GCGTTGGTGG TGTTTTGCGC GGCGACTTCG ACGGTTTCGG GCGCGTTCAT351 GAAGTCTTGC GCCAGTTTGC GTATCGGGGC GGAGAAGGTG GCGGAAAAGA 401GCAGGGTTTG GCGTTGGCGG GGCAGCATCT GCATGATTTT GCGGATGTCG 451 TCGATAAAACCCATATCCAG CATACGGTCG GCTTCGTCCA AAACGACGAT 501 TTCGACTTTG TTCAAATGGATGTTTTTCTG TTTCACGTGG TCGAGCAGCC 551 GTCCGACGGT GGCGACGACG ATTTCGCAGCCGGCACGCAG GTCGGCGGTC 601 TGTTTGTCCA TATTCATACC GCCGAACAAG ACGGTGTGGCGCAGCGGCAG 651 GTTTTTGATG TAGThis corresponds to the amino acid sequence <SEQ ID 2240; ORF 680>:

m680.pep 1 MTKGSSAMSS PRAAMSVATR TRRLPSLKAL SVSSRLCWER SPCIACADRL 51RRTSSRVTRS TLCLVLQNTM TWFICKSTIS RSSRLRF*MV STAMMCCSTL 101 ALVVFCAATSTVSGAFMKSC ASLRIGAEKV AEKSRVWRWR GSICMILRMS 151 SIKPISSIRS ASSKTTISTLFKWMFFCFTW SSSRPTVATT ISQPARRSAV 201 CLSIFIPPNK TVWRSGRFLM *Computer analysis of this amino acid sequence gave the followingresults:

m680/g680 90.9% identity in 220 aa overlap        10        20        30        40        50        60 m680.pepMTKGSSAMSSPRAAMSVATRTRRLPSLKALSVSSRLCWERSPCIACADRLRRTSSRVTRS||||||||||||||:||||||||||||||||||| ||||||||||||||||||||||||| g680MTKGSSAMSSPRAAISVATRTRRLPSLKALSVSSLLCWERSPCIACADRLRRTSSRVTRS        10        20        30        40        50        60        70        80        90       100       110       120 m680.pepTLCLVLQNTMTWFICKSTISRSSRLRFXMVSTAMMCCSTLALVVFCAATSTVSGAFMKSC|||||||:|:|||||:||||||||||| ||||||||||||||||  |||||||||||||| g680TLCLVLQKTITWFICRSTISRSSRLRFWKVSTAMMCCSTLALVVFWAATSTVSGAFMKSC        70        80        90       100       110       120       130       140       150       160       170       180 m680.pepASLRIGAEKVAEKSRVWRWRGSICMILRMSSIKPISSIRSASSKTTISTLFKWMFFCFTW||||||||||||||||||||||||||||||||:|||::|||||:||||:||| ||||||| g680ASLRIGAEKVAEKSRVWRWRGSICMILRMSSINPISNMRSASSRTTISALFKLMFFCFTW       130       140       150       160       170       180       190       200       210       220 m680.pepSSSRPTVATTISQPARRSAVCLSIFIPPNKTVWRSGRFLMX |||||||||||||||||||||||::||::|| |||||||| g680 SSSRPTVATTISQPARRSAVCLSMLTPPKRTVCRSGRFLMX       190       200       210       220The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2241>:

a680.seq 1 ATGACGAAGG GCAGTTCGGC AATATCCAGC CCCCGCGCGG CGATATCGGT 51GGCGACGAGG ACGCGCAGGT TGCCGTCTTT GAAGGCGTTG AGTGTTTCGA 101 GCCGGCTTTGTTGGGAACGG TCGCCGTGTA TCGCCTGTGC GGACAGGTTG 151 CGGCGCACCA GTTCGCGCGTTACGCGGTCG ACGCTTTGTT TGGTTTTGCA 201 GAACACGATG ACCTGGTTCA TATGCAAATCGACAATCAGC CGTTCGAGCA 251 GGTTGCGCTT CTGAATGGTA TCGACGGCGA TGATGTGCTGCTCGACGTTG 301 GCGTTGGTGG TGTCTTGCGC GGCGACTTCG ACGGTTTCGG GCGCGTTCAT351 GAAGTCTTGC GCCAGTTTGC GTATCGGGGC GGAGAAGGTG GCGGAAAAGA 401GCAGGGTTTG GCGTTGGCGG GGCAGCATCT GCATGATTTT GCGGATGTCG 451 TCGATAAAACCCATATCCAG CATACGGTCG GCTTCGTCCA AAACGACGAT 501 TTCGACTTTG TTCAAATGGATGTTTTTCTG TTTCACGTGG TCGAGCAGCC 551 GTCCGACGGT GGCGACGACG ATTTCGCAGCCGGCACGCAG GTCGGCGGTC 601 TGTTTGTCCA TATTCATACC GCCGAACAAG ACGGTGTGGCGCAGCGGCAG 651 GTTTTTGATG TAGThis corresponds to the amino acid sequence <SEQ ID 2242; ORF 680.a>:

a680.pep 1 MTKGSSAISS PRAAISVATR TRRLPSLKAL SVSSRLCWER SPCIACADRL 51RRTSSRVTRS TLCLVLQNTM TWFICKSTIS RSSRLRF*MV STAMMCCSTL 101 ALVVSCAATSTVSGAFMKSC ASLRIGAEKV AEKSRVWRWR GSICMILRMS 151 SIKPISSIRS ASSKTTISTLFKWMFFCFTW SSSRPTVATT ISQPARRSAV 201 CLSIFIPPNK TVWRSGRFLM * m680/a68098.6% identity in 220 aa overlap        10        20        30        40        50        60 m680.pepMTKGSSAMSSPRAAMSVATRTRRLPSLKALSVSSRLCWERSPCIACADRLRRTSSRVTRS|||||||:||||||:||||||||||||||||||||||||||||||||||||||||||||| a680MTKGSSAISSPRAAISVATRTRRLPSLKALSVSSRLCWERSPCIACADRLRRTSSRVTRS        10        20        30        40        50        60        70        80        90       100       110       120 m680.pepTLCLVLQNTMTWFICKSTISRSSRLRFXMVSTAMMCCSTLALVVFCAATSTVSGAFMKSC|||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||| a680TLCLVLQNTMTWFICKSTISRSSRLRFXMVSTAMMCCSTLALVVSCAATSTVSGAFMKSC        70        80        90       100       110       120       130       140       150       160       170       180 m680.pepASLRIGAEKVAEKSRVWRWRGSICMILRMSSIKPISSIRSASSKTTISTLFKWMFFCFTW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a680ASLRIGAEKVAEKSRVWRWRGSICMILRMSSIKPISSIRSASSKTTISTLFKWMFFCFTW       130       140       150       160       170       180       190       200       210       220 m680.pepSSSRPTVATTISQPARRSAVCLSIFIPPNKTVWRSGRFLMX||||||||||||||||||||||||||||||||||||||||| a680SSSRPTVATTISQPARRSAVCLSIFIPPNKTVWRSGRFLMX       190       200       210       220The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2243>:

g681.seq 1 ATGACGACGC CGATGGCAAT CAGTGCGTCA AATTTTTCGG AAGAGGCAAA 51GTTCATCAGC GCGATGGGGA TTTCAAGCGC GCCGGGTACG GTGGcgacgg 101 tgatgtTTTCGTCTGCTACG CCCAATTCTT GGAGGGTGCG GCAGCAGACT 151 TTGAGCATTT GGCTGCCGATTTCGTTGGTG AAGCGTGCCT GTACGATGCC 201 GATGCGGAGG TGTTTGCcgt cgaggttgGGGGCGATGGTG TTCATTGGGT 251 GTCCTTTGGT ATTCGGGGTT TCGGAATGCC GTCTGAAGGTTTCAGTCTTG 301 CGGCTGCCAG TCGGCAACGG TTTGGAATGT GCCGTCTTCG GCAAGCTCCC351 ACGCGCTGCC TTCGGGTTGG GAAAGCAGTG CGGCGGTTTC AGGGTTGGTT 401TTGGTGATGT CGGCGAGGCT GACGATGCTG AAGTTGTCGG GGTCGTCGGT 451 GTATTCGTCGGTTTCGTCGC CGCTGAAGAA ACGCCAGCCG CTGTCGTTTT 501 CAAAAACGGG GGCTTCGCGGTAAAGGAAGC CGACGGGCCG GTTTTGTTTG 551 GCGACGGTGT TGGTGGCGAT GCAGCGGTCGAGTGCCGAGG AAAGTGCTTG 601 TGCAAATGCG TTCATTGCGG GAATACGTTG GGGGGGGGGAAACTTGCGGA 651 TTTTACCACG ATTCCCGCGT TGTCGGCAGA CGGCGGCGGT TTGGTGGTAC701 AATGTGCGCC GTTTGCAGCC TTAAGGTGTT TCTGTATTTT TGGAGTATGG 751AAACGCATTC GGGCTGTTTT TTGCGGAAGA CGGTAAThis corresponds to the amino acid sequence <SEQ ID 2244; ORF 681>:

g681.pep 1 MTTPMAISAS NFSEEAKFIS AMGISSAPGT VATVMFSSAT PNSWRVRQQT 51LSIWLPISLV KRACTMPMRR CLPSRLGAMV FIGCPLVFGV SECRLKVSVL 101 RLPVGNGLECAVFGKLPRAA FGLGKQCGGF RVGFGDVGEA DDAEVVGVVG 151 VFVGFVAAEE TPAAVVFKNGGFAVKEADGP VLFGDGVGGD AAVECRGKCL 201 CKCVHCGNTL GGGKLADFTT IPALSADGGGLVVQCAPFAA LRCFCIFGVW 251 KRIRAVFCGR R*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2245>:

m681.seq 1 ATGACGACGC CGATGGCAAT CAGTGCGTCA AACTTTTCGG AAGAGGCAAA 51GTTCATCAGC GCGATGGGGA TTTCAAGCGC GCCGGGTACG GTGGCGACGG 101 TAATGTTTTCGTCTGCCACG CCCAATTCTT GGAGGGTGCG GCAGCAGACT 151 TTGAGCATTT CGCTGCCGATTTCGTTGGTG AAGCGTGCCT GTACGATGCC 201 GATGCGGAGG TGTTTGCCGT CGAGGTTGGGGGCGATGGTG TTCATTGGGT 251 GTCCTTTGGT ATTCGGAGTT TCGGAATGCC GTCTGAAGGTTTCAGTCTTG 301 CGGCTGCCAG TCGGCGACGG TTTGGAATGT GCCGTCTTCG GCAAGCTCCC351 ATGCGCTGCC TTCGGGTTGG GAGAGCAGTG CGGCGGTTTC AGGGTTGGTT 401TTGGCGATGT CGGCGAGGCT GACGATGCTG AAGTTGTCCG GATCGTCGGT 451 GTATTCGTCGGTCTCGTCGC CGCTGAAGAA ACGCCAGCCG CTGTCGTTTT 501 CAAAAACGGG GGCTTCGCGGTAGAGGAAGC CGACGGGCCG GTTTTGTTTG 551 GCGACGGTGT TGGTGGCGAT ACAGCGGTCGAGTGCCGAGG AAAGTGCTTG 601 TGCAAATGCG TTCATTACGG GAATACGTTG GGGG.AAAACTTACGGATTT 651 TACCACGATT CGTGCGTTGT CGGCAGACGG CGGCGGTTTG GTGGTACAAT701 GTGCGCCGTT TGCAGCCTTA AGGTGTTTCT GTATTTTTGG AGTATGGAAA 751CGCATTCGGG CTGTTTTTTG CGGAAGACGG TAAThis corresponds to the amino acid sequence <SEQ ID 2246; ORF 681>:

m681.pep 1 MTTPMAISAS NFSEEAKFIS AMGISSAPGT VATVMFSSAT PNSWRVRQQT 51LSISLPISLV KRACTMPMRR CLPSRLGAMV FIGCPLVFGV SECRLKVSVL 101 RLPVGDGLECAVFGKLPCAA FGLGEQCGGF RVGFGDVGEA DDAEVVRIVG 151 VFVGLVAAEE TPAAVVFKNGGFAVEEADGP VLFGDGVGGD TAVECRGKCL 201 CKCVHYGNTL GXKLTDFTTI RALSADGGGLVVQCAPFAAL RCFCIFGVWK 251 RIRAVFCGRR *Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 681 shows 94.6% identity over a 261 aa overlap with a predicted ORF(ORF681.a) from N. gonorrhoeae:

m681/g681           10        20        30        40        50        60m681.pep   MTTPMAISASNFSEEAKFISAMGISSAPGTVATVMFSSATPNSWRVRQQTLSISLPISLV  ||||||||||||||||||||||||||||||||||||||||||||||||||||| |||||| g681  MTTPMAISASNFSEEAKFISAMGISSAPGTVATVMFSSATPNSWRVRQQTLSIWLPISLV          10        20        30        40        50        60          70        80        90       100       110       120 m681.pep  KRACTMPMRRCLPSRLGAMVFIGCPLVFGVSECRLKVSVLRLPVGDGLECAVFGKLPCAA  |||||||||||||||||||||||||||||||||||||||||||||:||||||||||||| g681  KRACTMPMRRCLPSRLGAMVFIGCPLVFGVSECRLKVSVLRLPVGNGLECAVFGKLPRAA          70        80        90       100       110       120         130       140       150       160       170       180 m681.pep  FGLGEQCGGFRVGFGDVGEADDAEVVRIVGVFVGLVAAEETPAAVVFKNGGFAVEEADGP  ||||:||||||||||||||||||||| :||||||:|||||||||||||||||||:||||| g681  FGLGKQCGGFRVGFGDVGEADDAEVVGVVGVFVGFVAAEETPAAVVFKNGGFAVKEADGP         130       140       150       160       170       180         190       200       210        220       230      239 m681.pep  VLFGDGVGGDTAVECRGKCLCKCVHYGNTLGX-KLTDFTTIRALSADGGGLVVQCAPFAA  ||||||||||:|||||||||||||| |||||  ||:||||| |||||||||||||||||| g681  VLFGDGVGGDAAVECRGKCLCKCVHCGNTLGGGKLADFTTIPALSADGGGLVVQCAPFAA         190       200       210       220       230       240240       250       260 m681.pep   LRCFCIFGVWKRIRAVFCGRRX  |||||||||||||||||||||| g681   LRCFCIFGVWKRIRAVFCGRRX         250       260The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2247>:

a681.seq 1 ATAACGACGC CGATGGCAAT CAGTGCGTCA AATTTTTCAG AAGAGGCAAA 51GTTCATCAGC GCGATGGGGA TTTCAAGCGC GCCGGGTACG GTGGCGACGG 101 TAATGTTTTCGTCTGCCACG CCCAATTCTT GGAGGGTGCG GCAGCAGACT 151 TTGAGCATTT CGCTGCCGATTTCGTTGGTG AAGCGTGCCT GTACGATGCC 201 GATGCGGAGG TGTTTGCCGT CGAGGTTGGGGGCGATGGTG TTCATTGAGT 251 GTCCTTTGGT ATTCGGAGGT TTCGGAATGC CGTCTGAAGGGTCAGTCCTT 301 AGGTTGCCAG TCGGCGACGG TTTGGAATGT GCCGTCTTCT GCCAATTCCC351 ACGCGCTGCC TTCAGGTTGG GAGAGCAGTG CGGCGGTTTC AGGGTTGGTT 401TTGGTGATAT CGGCGAGGCT GACGATGCTG AAGTTGTCCG GGTCGTCGGT 451 GTATTCGTCGGTCTCGTCGC CGCTGAAGAA ACGCCAGCCG CTGTCGTTTT 501 CAAAAACGGG GGCTTCGCGGTAGAGGAAGC CGACGGGCTG GTTTTGTTTG 551 GCGACGGTGT TGGTGGCGAT GCAGCGGTCGAGTGCCGAGG AAAGTGCTTG 601 TGCAAATGCG TTCATTGCGG GAATACGTT. GGGGGAAAACTTGCGGATTT 651 TACCACGATT CTTGCGTTGT CGGCAGACGG CGGCGGTTTG GTGGTACAAT701 GTGCGCCGTT TGCAGCCTTA AGGTGTTTCT GTATTTTTGG AGTATGGAAA 751CGCATTCGGG CTGTTTTTTG CGGAAGACGG TAAThis corresponds to the amino acid sequence <SEQ ID 2248; ORF 681.a>:

a681.pep 1 ITTPMAISAS NFSEEAKFIS AMGISSAPGT VATVMFSSAT PNSWRVRQQT 51LSISLPISLV KRACTMPMRR CLPSRLGAMV FIECPLVFGG FGMPSEGSVL 101 RLPVGDGLECAVFCQFPRAA FRLGEQCGGF RVGFGDIGEA DDAEVVRVVG 151 VFVGLVAAEE TPAAVVFKNGGFAVEEADGL VLFGDGVGGD AAVECRGKCL 201 CKCVHCGNTX GGKLADFTTILALSADGGGL VVQCAPFAAL RCFCIFGVWK 251 RIRAVFCGRR * m681/a681 90.8%identity in 260 aa overlap        10        20        30        40        50        60 m681.pepMTTPMAISASNFSEEAKFISAMGISSAPGTVATVMFSSATPNSWRVRQQTLSISLPISLV:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a681ITTPMAISASNFSEEAKFISAMGISSAPGTVATVMFSSATPNSWRVRQQTLSISLPISLV        10        20        30        40        50        60        70        80        90       100       110       120 m681.pepKRACTMPMRRCLPSRLGAMVFIGCPLVFGVSECRLKVSVLRLPVGDGLECAVFGKLPCAA||||||||||||||||||||||||||||      :|||||||||||||||| ::| || a681KRACTMPMRRCLPSRLGAMVFIECPLVFGGFGMPSEGSVLRLPVGDGLECAVFCQFPRAA        70        80        90       100       110       120       130       140       150       160       170       180 m681.pepFGLGEQCGGFRVGFGDVGEADDAEVVRIVGVFVGLVAAEETPAAVVFKNGGFAVEEADGP| ||||||||||||||:||||||||||:||||||||||||||||||||||||||||||| a681FRLGEQCGGFRVGFGDIGEADDAEVVRVVGVFVGLVAAEETPAAVVFKNGGFAVEEADGL       130       140       150       160       170       180       190       200       210       220       230       240 m681.pepVLFGDGVGGDTAVECRGKCLCKCVHYGNTLGXKLTDFTTIRALSADGGGLVVQCAPFAAL||||||||||:|||||||||||||| ||| | ||:||||| ||||||||||||||||||| a681VLFGDGVGGDAAVECRGKCLCKCVHCGNTXGGKLADFTTILALSADGGGLVVQCAPFAAL       190       200       210       220       230       240       250       260 m681.pep RCFCIFGVWKRIRAVFCGRRX||||||||||||||||||||| a681 RCFCIFGVWKRIRAVFCGRRX        250       260The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2249>:

g682.seq 1 ATGCGCGATT TCGCCGTATG GGTGCCTTAC GGGGAACGGC GGAAAAATTG 51GGACATAAGG TATTGCCTCC CGCACCTTAT TCGCCTGAGC CCAACCCGAT 101 TGAGAAAGTGTGGGCGAATA TTAAGCGGTA TCTGCGAACC GTTTTGTCTG 151 ATTACGCCCG ATTTGACGATGCACTACTGT CCTATTTTGA TTTTAATTGA 201 CTATATTTGT GTGAATGATG AAATAAAAATGCCGTCTGAA CCCGATTGGA 251 TTCAGACGGC ATTTTGTATG GCAGGATTTA TTCGCTTTCCAACTGACCGA 301 CCTATTTTGA CAAGGCAGTC AGGCGTTGTT CGGATTTCGC CACGAACGGG351 TTTTCGGTAT CCCACGCGTA GCCTGCCAAA ATCGAAGAAA GCATACGGCT 401 GAThis corresponds to the amino acid sequence <SEQ ID 2250; ORF 682>:

g682.pep 1 MRDFAVWVPY GERRKNWDIR YCLPHLIRLS PTRLRKCGRI LSGICEPFCL 51ITPDLTMHYC PILILIDYIC VNDEIKMPSE PDWIQTAFCM AGFIRFPTDR 101 PILTRQSGVVRISPRTGFRY PTRSLPKSKK AYG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2251>:

m682.seq 1 ATGCGTGATT TCACCGTATG GGTGTCTTAC GGGAAATGGC GGAAAAATTG 51GGACATAAGG TATTGCCTCT TGCACCTTAT TCACCTGAGC TCAACCCGAT 101 TGAGAAAGTGTGGGCGAATA TTAAGCGGTA TCTGCGAACC GTTTTGTCTG 151 ATTACGCCCG ATTTGACGATGCACTACTGT CCTATTTTGA TTTTAATTGA 201 CTAT...... ......GAAA TGGCAATGCCGTCTGAACCC GATTGGATTC 251 AGACGGCATT TTGTATGGCG TACGGATTTA TTCGGTTTCCAACTGACCGA 301 CCCATTCGGA CAAGGCAGTC AGGCGTTGTT CGGATTTCGC CACGAACGGG351 TTTTCGGTAT CCCACGCGTA GCCTGCCAAA ATCGAAGAAA GCATACGGCT 401 GAThis corresponds to the amino acid sequence <SEQ ID 2252; ORF 682>:

m682.pep 1 MRDFTVWVSY GKWRKNWDIR YCLLHLIHLS STRLRKCGRI LSGICEPFCL 51ITPDLTMHYC PILILIDY.. ..EMAMPSEP DWIQTAFCMA YGFIRFPTDR 101 PIRTRQSGVVRISPRTGFRY PTRSLPKSKK AYG*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 682 shows 88.1% identity over a 134 aa overlap with a predicted ORF(ORF682.a) from N. gonorrhoeae:

m682/g682           10        20        30        40        50        60m682.pep   MRDFTVWVSYGKWRKNWDIRYCLLHLIHLSSTRLRKCGRILSGICEPFCLITPDLTMHYC  ||||:||| ||: |||||||||| |||:|| ||||||||||||||||||||||||||||| g682  MRDFAVWVPYGERRKNWDIRYCLPHLIRLSPIRLRKCGRILSGICEPFCLITPDLIMHYC          10        20        30        40        50        60               70        80        90       100       110 m682.pep  PILILIDY-----EMAMPSEPDWIQTAFCMAYGFIRFPTDRPIRTRQSGVVRISPRTGFR  ||||||||     |:  ||||||||||||||| ||||||||||| |||||||||||||||| g682  PILILIDYICVNDEIKMPSEPDWIQTAFCMA-GFIRFPTDRPILTRQSGVVRISPRTGFR          70        80        90        100       110     120       130m682.pep   YPTRSLPKSKKAYGX   |||||||||||||||| g682   YPTRSLPKSKKAYGX120       130The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2253>:

a682.seq 1 ATGCGCGATT TTACCGTATG GGTGTCTTAC GGGAAATGGC GGAAAAATTG 51GGACATAAGG TATTGCCTCT TGCACCTTAT TCACCTGAGC TCAACCCGAT 101TGAGAAAGTG TGGGCGAATA TTAAGCGGTA TCTGCGAACC GTTTTGTCTG 151ATTACGCCCG ATTTGACGAT GCACTACTGT CCTATTTTGA TTTTAATTGA 201ATAT...... .......... .......... .......... .......... 251.......... .......... ......TATA TTCGGTTTCC AACTGACCGA 301CCCATTCTGA CAAGGCCGAC AGGCGTTGTT CGGATTTCGC CACGAACGGG 351TTTTCGGTAT CCCACGCGTA GCCTGCCAAA ATCGAAGAAA GCATACGGCT 401 GAThis corresponds to the amino acid sequence <SEQ ID 2254; ORF 682.a>:

a682.pep 1 MRDFTVWVSY GKWRKNWDIR YCLLHLIHLS STRLRKCGRI LSGICEPFCL 51ITPDLTMHYC PILILIEY.. .......... .......... ..YIRFPTDR 101PILTRPTGVV RISPRTGFRY PTRSLPKSKK AYG* m682/a68280.6% identity in 129 aa overlap        10        20        30        40        50        60 m682.pepMRDFTVWVSYGKWRKNWDIRYCLLHLIHLSSTRLRKCGRILSGICEPFCLITPDLTMHYC|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a682MRDFTVWVSYGKWRKNWDIRYCLLHLIHLSSTRLRKCGRILSGICEPFCLITPDLIMHYC        10        20        30        40        50        60        70        80        90       100       110       120 m682.pepPILILIDYEMAMPSEPDWIQTAFCMAYGFIRFPTDRPIRTRQSGVVRISPRTGFRYPTRS||||||:|||||||||||||||||||||:||||||||| || :||||||||||||||||| a682PILILIEY--------------------YIRFPTDRPILTRPTGVVRISPRTGFRYPTRS                            70        80        90       100        130m682.pep LPKSKKAYGX |||||||||| a682 LPKSKKAYGX        110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2255>

g683.seq 1 ATGATTAAGG AAACCCTAAT GCGCCCAATC TTCCTATCTT TCGTTTTACT 51CCCTATTTTG ATAACCGCCT GCAGCACACC GGACAAGTCT GCCCGATGGG 101AAAATATCGG CACAATCTCA AACGGCAATA TTCATACATA TATTAATAAA 151GACAGTGTGA GAAAAAACGG AAATCTGATG ATTTTCCAAG ATAAAAAAGT 201TGTTACCAAT CTGAAACAAG AACGTTTTGC CAACACCCCC GCATACAAGA 251CTGCCATTGC CGAGTGGGAA ATCCACTGCA ACAACAAAAC ATACCGCTTA 301AGTTCGCTAC AGTTATTTGA TACAAAAAAC ACGGAAATTT CCACACAAAA 351CTACACAGCC TCTTCCCTCC GCCCGATGAG CATCCTGTCC GGGACATTAA 401CTGAAAAACA ATATGAAACC GTATGCGGGA AAAAACTCTG AThis corresponds to the amino acid sequence <SEQ ID 2256; ORF 683>:

g683.pep 1 MIKETLMRPI FLSFVLLPIL ITACSTPDKS ARWENIGTIS NGNIHTYINK 51DSVRKNGNLM IFQDKKVVTN LKQERFANTP AYKTAIAEWE IHCNNKTYRL 101SSLQLFDTKN TEISTQNYTA SSLRPMSILS GTLTEKQYET VCGKKL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2257>:

m683.seq.. 1 ATGATTAAGG AAACCCTAAT GCGCCCAATC TTCCTATCTT TCGTTTTATT 51CCCTATTTTG ATAACCGCCT GCAGCACACC GGACAAGTCT GCCCGATGGG 101AAAATATCGG CACAATCTCA AACGGCAATA TTCATACATA TATCAATAAA 151GACAGCGTGA GAAAAAACGG AAATCTGATG ATTTTCCAAG ATAAAAAAGT 201TGTTACCAAT CTAAAACAAG AACGTTTTGC CAACACCCCC GCATACAAGA 251CTGCCATTGC CGAGTGGGAA ATCCACTGCA ACAACAAAAC ATACCGCTTA 301AGTTCGCTAC AGTTGTTTGA TACAAAAAAC ACGGAAATTT CCACACAAAA 351CTACACAGCC TCTTCCCTCC GCCCGATGAG CATCCTGTCC GGGACATTAA 401CCGAAAAACA ATATGAAACC GTATGCGGAA AAAAACTCTG AThis corresponds to the amino acid sequence <SEQ ID 2258; ORF 683>:

m683.pep.. 1 MIKETLMRPI FLSFVLFPIL ITACSTPDKS ARWENIGTIS NGNIHTYINK 51DSVRKNGNLM IFQDKKVVTN LKQERFANTP AYKTAIAEWE IHCNNKTYRL 101SSLQLFDTKN TEISTQNYTA SSLRPMSILS GTLTEKQYET VCGKKL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 683 shows 99.3% identity over a 146 aa overlap with a predicted ORF(ORF 683) from N. gonorrhoeae:

m683/g683 99.3% identity in 146 aa overlap        10        20        30        40        50        60 m683.pepMIKETLMRPIFLSFVLFPILITACSTPDKSARWENIGTISNGNIHTYINKDSVRKNGNLM||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||| g683MIKETLMRPIFLSFVLLPILITACSTPDKSARWENIGTISNGNIHTYINKDSVRKNGNLM        10        20        30        40        50        60        70        80        90       100       110       120 m683.pepIFQDKKVVTNLKQERFANTPAYKTAIAEWEIHCNNKTYRLSSLQLFDTKNTEISTQNYTA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g683IFQDKKVVTNLKQERFANTPAYKTAIAEWEIHCNNKTYRLSSLQLFDTKNTEISTQNYTA        70        80        90       100       110       120       130       140 m683.pep SSLRPMSILSGTLTEKQYETVCGKKLX||||||||||||||||||||||||||| g683 SSLRPMSILSGTLTEKQYETVCGKKLX       130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2259>

a683.seq 1 ATGATTAAGG AAACCCTAAT GCGCCCAATC TTCCTATCTT TCGTTTTATT 51CCCTATTTTG ATAACCGCCT GCAGCACACC GGACAAGTCT GCCCGATGGG 101AAAATATCGG CACAATCTCA AACGGCAATA TTCATACATA TATCAATAAA 151GACAGCGTGA GAAAAAACGG AAATCTGATG ATTTTCCNAG ATAAAAAAGT 201TGTTACCAAT CTAAAACAAG AACGTTTTGC CNACACCCCC GCATACAAGA 251CTGCCATTGC CGAGTGGGAA ATCCACTGCA ACAACAAAAC ATACCGCTTA 301AGTTCGCTAC AATTGTTTGA TACAAAAAAC ACGGAAATTT CCACACAAAA 351NTACACAGCC TCTTCCCTCC GCCCGATGAG CATCCTGTCC GGGACATTAA 401CCGAAAAACA ATATGAAACC GTATGCGGAA AAAAACTCTG AThis corresponds to the amino acid sequence <SEQ ID 2260; ORF 683.a>:

a683.pep 1 MIKETLMRPI FLSFVLFPIL ITACSTPDKS ARWENIGTIS NGNIHTYINK 51DSVRKNGNLM IFXDKKVVTN LKQERFAXTP AYKTAIAEWE IHCNNKTYRL 101SSLQLFDTKN TEISTQXYTA SSLRPMSILS GTLTEKQYET VCGKKL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 683 shows 97.9% identity over a 146 aa overlap with a predicted ORF(ORF 683) from N. meningitidis:

m683/a683 97.9% identity in 146 aa overlap        10        20        30        40        50        60 m683.pepMIKETLMRPIFLSFVLFPILITACSTPDKSARWENIGTISNGNIHTYINKDSVRKNGNLM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a683MIKETLMRPIFLSFVLFPILITACSTPDKSARWENIGTISNGNIHTYINKDSVRKNGNLM        10        20        30        40        50        60        70        80        90       100       110       120 m683.pepIFQDKKVVTNLKQERFANTPAYKTAIAEWEIHCNNKTYRLSSLQLFDTKNTEISTQNYTA |||||||||||||||| |||||||||||||||||||||||||||||||||||||| ||| a683IFXDKKVVTNLKQERFAXTPAYKTAIAEWEIHCNNKTYRLSSLQLFDTKNTEISTQXYTA        70        80        90       100       110       120       130       140 m683.pep SSLRPMSILSGTLTEKQYETVCGKKLX||||||||||||||||||||||||||| a683 SSLRPMSILSGTLTEKQYETVCGKKLX       130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2261>

g684.seq 1 ATGCGCCTTT TCCCCATCGC CGCCGCCCTG ACGCTTGCCG CCTGCGGTAC 51TGTGCAAAGC ACACAATATT TCGTGTTGCC CGACAGCCGC TACATCCGTC 101CTGCAACGCA AGGCGGCGAA ACCGCCGTCG AAGTCCGTCT TGCCGAACCG 151CTCAAACGCG GCGGACTGGT CTATCAAACC GACCCCTACC GCATCAACAC 201CGCACAAAAC CATGTTTGGG CAGACACCTT GGACGATATG CTCGAAGCGG 251CGTTGAGCAA TGCATTCAAC CGTTTGGACA GCACACGCAC CTTTGTTCCT 301GCCTCACGCA GCGGCAGTAC CGACAAATGG ACGGTCTATA TCGACGCATT 351CCAAGGCAGC TACACGGGCA AAACCCTCAT CAGCGGCTAC GCCGTCCTAC 401CCGACGGTAC GAACAGACCC TTCCATATCG AAACCGAACA GCAGGGTGAC 451GGCTACGCCG CCATGACCGC CGCACTCGAA CAGGGACTGA AACAGGCGGC 501GCAACAGATG GTCGAGTAAThis corresponds to the amino acid sequence <SEQ ID 2262; ORF 684>:

g684.pep 1 MRLFPIAAAL TLAACGTVQS TQYFVLPDSR YIRPATQGGE TAVEVRLAEP 51LKRGGLVYQT DPYRINTAQN HVWADTLDDM LEAALSNAFN RLDSTRTFVP 101ASRSGSTDKW TVYIDAFQGS YTGKTLISGY AVLPDGTNRP FHIETEQQGD 151GYAAMTAALE QGLKQAAQQM VE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2263>:

m684.seq 1 ATGCGCCTTT TCCCGATTGC CGCCGCCCTG TCGCTTGCCG CCTGCGGTAC 51TGTGCAAAGC ACACAATATT TCGTGTTGCC CGACAGCCGC TACATCCGTC 101CTGCAACGCA AGGCGGCGAA ACTGCCGTCG AAGTCCGTCT TGCCGAACCG 151CTCAAACGCG GCGGACTGGT CTATCAAACC GACCCCTACC GCCTCAACAC 201CGCACAAAAC CACGTCTGGG CAGACACCTT GGACGATATG CTCGAAGCGG 251CGTTGAGCAA TGCATTCAAC CGTTTGGACA GCACACGCAT CTTTGTTCCT 301GCCTCACGCA GCGGCAGTAC CGAAAAATGG ACGGTCTATA TCGACGCATT 351CCAAGGCAGC TACACGGGCA AAACCCTCAT CAGCGGCTAC GCCGTCCTAC 401CCGACGGTAC GAACAGACCC TTCCATATCG AAACCGAACA GCAGGGTGAC 451GGCTACGCCG CGATGACCGC CGCACTCGAA CAGGGACTGA AACAGGCGGC 501GCAACAGATG GTCGAGTAAThis corresponds to the amino acid sequence <SEQ ID 2264; ORF 684>:

m684.pep 1 MRLFPIAAAL SLAACGTVQS TQYFVLPDSR YIRPATQGGE TAVEVRLAEP 51LKRGGLVYQT DPYRLNTAQN HVWADTLDDM LEAALSNAFN RLDSTRIFVP 101ASRSGSTEKW TVYIDAFQGS YTGKTLISGY AVLPDGTNRP FHIETEQQGD 151GYAAMTAALE QGLKQAAQQM VE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 684 shows 97.7% identity over a 172 aa overlap with a predicted ORF(ORF 684) from N. gonorrhoeae:

m684/g684 97.7% identity in 172 aa overlap        10        20        30        40        50        60 m684.pepMRLFPIAAALSLAACGTVQSTQYFVLPDSRYIRPATQGGETAVEVRLAEPLKRGGLVYQT||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||| g684MRLFPIAAALTLAACGTVQSTQYFVLPDSRYIRPATQGGETAVEVRLAEPLKRGGLVYQT        10        20        30        40        50        60        70        80        90       100       110       120 m684.pepDPYRLNTAQNHVWADTLDDMLEAALSNAFNRLDSTRIFVPASRSGSTEKWTVYIDAFQGS||||:||||||||||||||||||||||||||||||| ||||||||||:|||||||||||| g684DPYRINTAQNHVWADTLDDMLEAALSNAFNRLDSTRTFVPASRSGSTDKWTVYIDAFQGS        70        80        90       100       110       120       130       140       150       160       170 m684.pepYTGKTLISGYAVLPDGTNRPFHIETEQQGDGYAAMTAALEQGLKQAAQQMVEX||||||||||||||||||||||||||||||||||||||||||||||||||||| g684YTGKTLISGYAVLPDGTNRPFHIETEQQGDGYAAMTAALEQGLKQAAQQMVEX       130       140       150       160       170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2265>

a684.seq 1 ATGCGCCTCT TCCCGATTGC CGCCGCCCTG ACGCTTGCCG CCTGCGGTAC 51TGTGCAAAGC ACACAATATT TCGTGTTGCC CGACAGCCGC TACATCCGTC 101 CTGCAACGCAAGGCGGCGAA ACTGCCGTCG AAGTCCGTCT TGCCGAACCG 151 CTCAAACGCG GCGGACTGGTCTATCAAACC GACCCCTACC GCCTCAACAC 201 CGCACAAAAC CACGTCTGGG CAGACACCTTGGACGATATG CTCGAAGCGG 251 CGTTGAGCAA TGCATTCAAC CGTTTGGACA GCACACGCATCTTTGTTCCT 301 GCCTCACGCA GCGGCAGTAC CGAAAAATGG ACGGTCTATA TCGACGCATT351 CCAAGGCAGC TACACGGGCA AAACCCTCAT CAGCGGCTAC GCCGTCCTAC 401CCGACGGTAC GAACAGACCC TTCCATATCG AAACCGAACA GCAGGGTGAC 451 GGCTACGCCGCCATGACCGC CGCACTCGAA CAGGGACTGA AACAGGCGGC 501 GCAACAGATG GTCGAGTAAThis corresponds to the amino acid sequence <SEQ ID 2266; ORF 684.a>:

a684.pep 1 MRLFPIAAAL TLAACGTVQS TQYFVLPDSR YIRPATQGGE TAVEVRLAEP 51LKRGGLVYQT DPYRLNTAQN HVWADTLDDM LEAALSNAFN RLDSTRIFVP 101 ASRSGSTEKWTVYIDAFQGS YTGKTLISGY AVLPDGTNRP FHIETEQQGD 151 GYAAMTAALE QGLKQAAQQMVE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 684 shows 99.4% identity over a 172 aa overlap with a predicted ORF(ORF 684) from N. meningitidis

m684/a684 99.4% identity in 172 aa overlap        10        20        30        40        50        60 m684.pepMRLFPIAAALSLAACGTVQSTQYFVLPDSRYIRPATQGGETAVEVRLAEPLKRGGLVYQT||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||| a684MRLFPIAAALTLAACGTVQSTQYFVLPDSRYIRPATQGGETAVEVRLAEPLKRGGLVYQT        10        20        30        40        50        60        70        80        90       100       110       120 m684.pepDPYRLNTAQNHVWADTLDDMLEAALSNAFNRLDSTRIFVPASRSGSTEKWTVYIDAFQGS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a684DPYRLNTAQNHVWADTLDDMLEAALSNAFNRLDSTRIFVPASRSGSTEKWTVYIDAFQGS        70        80        90       100       110       120       130       140       150       160       170 m684.pepYTGKTLISGYAVLPDGTNRPFHIETEQQGDGYAAMTAALEQGLKQAAQQMVEX||||||||||||||||||||||||||||||||||||||||||||||||||||| a684YTGKTLISGYAVLPDGTNRPFHIETEQQGDGYAAMTAALEQGLKQAAQQMVEX       130       140       150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2267>

g685.seq 1 TTGTTTTGCC GTATCGGGAA TTTTGCGTTT TGCGGCGTGG TTTCTGCAGG 51TTGTTTGCTT AATAATAAAC ATTCTTATTC GTATGCAAAG GAACCGCACA 101 CCGTGAAACCGCGTTTTTAT TGGGCAGcct GCGCCGTCCT GCCGGCCGCC 151 TGTTCGCCCG AACCTGCCGCCGAAAAAACT GTATccgCCG CATCCCAAGC 201 CGCATCCACA CCTGTCGCCA CGCTGACCGTGCCGACCGCG CGGGGCGATG 251 CCGTTGTGCC GAAGAATCCC GAACgcgtcg ccgtgtAcgaCtggGCGGCG 301 TtggaTACGC TGACCGAGCC GGGCGTGAAT GTGGGCGCAA CCACCGCGCC351 GGTGCGCGTG GACTATTTGC AGCCTGCATT TGACAAGGCG GCAACGGTGG 401GGACGCTGTT TGAGCCCGAT TGCGAATCCC TGCACCGCCA CAATCCGCAG 451 TTTGTCATTACCGGCGGGCC GGGTGCGGAA GCGTATGAAC AGTTGGCGAA 501 AAACGCGACC ACCATAGATTTGACGGTGGA CAACGGCAAT ATCCGCACCA 551 GCGGCGAGAA GCAGATGGAG ACCCTGTCGCGGATTTTCGG TAAGGAAGCG 601 CGCGTGGCGG AATTGAATGC GCAGATTGAC GCGCTGTTCGCCCAAAAGCG 651 CGAAGCCGCC AAAGGCAAAG GACGCGGGCT GGTGCTGTCG GTTACAGGCA701 ACAAGGTGTC CGCCTTCGGC ACGCAATCGC GGTTGGCAAG TTGGATACAC 751GGCGACATCG GCCTGCCGCC CGTGGACGAA TCTTTACGCA ACGAAGGGCA 801 CGGGCAGCCCGTTTCCTTCG AATACATCAA AGAGAAAAAC CCCGGCTGGA 851 TTTTCATCAT CGACCGCACCGCCGCCATCG GGCAGGAAGG GCCGGCTGCC 901 GTGGAAGTGT TGGATAACGC GCTGGTATGCGGCACGAACG CTTGGAAGCG 951 CAAGCAAATC ATCGTCATGC CTGCCGCGAA CTACATTGTCGCGGGCGGCG 1001 CGCGGCAGTT GATACAGGCG GCGGAACAGT TGAAGGCGGC GTTTGAAAAG1051 GCAGAACCCG TTGCGGCGCA GTAGThis corresponds to the amino acid sequence <SEQ ID 2268; ORF 685>:

g685.pep 1 LFCRIGNFAF CGVVSAGCLL NNKHSYSYAK EPHTVKPRFY WAACAVLPAA 51CSPEPAAEKT VSAASQAAST PVATLTVPTA RGDAVVPKNP ERVAVYDWAA 101 LDTLTEPGVNVGATTAPVRV DYLQPAFDKA ATVGTLFEPD CESLHRHNPQ 151 FVITGGPGAE AYEQLAKNATTIDLTVDNGN IRTSGEKQME TLSRIFGKEA 201 RVAELNAQID ALFAQKREAA KGKGRGLVLSVTGNKVSAFG TQSRLASWIH 251 GDIGLPPVDE SLRNEGHGQP VSFEYIKEKN PGWIFIIDRTAAIGQEGPAA 301 VEVLDNALVC GTNAWKRKQI IVMPAANYIV AGGARQLIQA AEQLKAAFEK351 AEPVAAQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2269>:

m685.seq 1 TTGTTTTGCC GTATCGGGAA TTTTGCGTTT TGCGGCGTGG TTTCTGCAGG 51TTGTTTGCTT AATAATAAAC ATTCTTATTC GTATGCAAAG GAACCGCACA 101 CCGTGAAACCGCGTTTTTAT TGGGCAGCCT GCGCCGTCCT GCTGACCGCC 151 TGTTCGCCCG AACCTGCCGCCGAAAAAACT GTATCCGCCG CATCCGCATC 201 TGCCGCCACG CTGACCGTGC CGACCGCGCGGGGCGATGCC GTTGTGCCGA 251 AGAATCCCGA ACGCGTCGCC GTGTACGACT GGGCGGCGTTGGATACGCTG 301 ACCGAATTGG GCGTGAATGT GGGCGCAACC ACCGCGCCGG TGCGCGTGGA351 TTATTTGCAG CCTGCATTTG ACAAGGCGGC AACGGTGGGG ACGCTGTTCG 401AGCCCGATTA CGAAGCCCTG CACCGCTACA ATCCTCAGCT TGTCATTACC 451 GGCGGGCCGGGCGCGGAAGC GTATGAACAG TTAGCGAAAA ACGCGACCAC 501 CATAGATCTG ACGGTGGACAACGGCAATAT CCGCACCAGC GGCGAAAAGC 551 AGATGGAGAC CTTGGCGCGG ATTTTCGGCAAGGAAGCGCG CGCGGCGGAA 601 TTGAAGGCGC AGATTGACGC GCTGTTCGCC CAAACGCGCGAAGCCGCCAA 651 AGGCAAAGGA CGCGGGCTGG TGCTGTCGGT TACGGGCAAC AAGGTGTCCG701 CCTTCGGCAC GCAGTCGCGG TTGGCAAGTT GGATACACGG CGACATCGGC 751CTACCGCCTG TAGACGAATC TTTACGCAAC GAGGGGCACG GGCAGCCTGT 801 TTCCTTCGAATACATCAAAG AGAAAAACCC CGATTGGATT TTCATCATCG 851 ACCGTACCGC CGCCATCGGGCAGGAAGGGC CGGCGGCTGT CGAAGTATTG 901 GATAACGCGC TGGTACGCGG CACGAACGCTTGGAAGCGCA AGCAAATCAT 951 CGTCATGCCT GCCGCGAACT ACATTGTCGC GGGCGGCGCGCGGCAGTTGA 1001 TTCAGGCGGC GGAGCAGTTG AAGGCGGCGT TTAAAAAGGC AGAACCCGTT1051 GCGGCGGGGA AAAAGTAGThis corresponds to the amino acid sequence <SEQ ID 2270; ORF 685>:

m685.pep 1 LFCRIGNFAF CGVVSAGCLL NNKHSYSYAK EPHTVKPRFY WAACAVLLTA 51CSPEPAAEKT VSAASASAAT LTVPTARGDA VVPKNPERVA VYDWAALDTL 101 TELGVNVGATTAPVRVDYLQ PAFDKAATVG TLFEPDYEAL HRYNPQLVIT 151 GGPGAEAYEQ LAKNATTIDLTVDNGNIRTS GEKQMETLAR IFGKEARAAE 201 LKAQIDALFA QTREAAKGKG RGLVLSVTGNKVSAFGTQSR LASWIHGDIG 251 LPPVDESLRN EGHGQPVSFE YIKEKNPDWI FIIDRTAAIGQEGPAAVEVL 301 DNALVRGTNA WKRKQIIVMP AANYIVAGGA RQLIQAAEQL KAAFKKAEPV351 AAGKK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 685 shows 94.4% identity over a 356 aa overlap with a predicted ORF(ORF 685) from N. gonorrhoeae:

m685/g685 94.4% identity in 356 aa overlap        10        20        30        40        50        60 m685.pepLFCRIGNFAFCGVVSAGCLLNNKHSYSYAKEPHTVKPRFYWAACAVLLTACSPEPAAEKT||||||||||||||||||||||||||||||||||||||||||||||| :||||||||||| g685LFCRIGNFAFCGVVSAGCLLNNKHSYSYAKEPHTVKPRFYWAACAVLPAACSPEPAAEKT        10        20        30        40        50        60            70        80        90       100       110 m685.pepVSAASASA----ATLTVPTARGDAVVPKNPERVAVYDWAALDTLTELGVNVGATTAPVRV||||| :|    |||||||||||||||||||||||||||||||||| ||||||||||||| g685VSAASQAASTPVATLTVPTARGDAVVPKNPERVAVYDWAALDTLTEPGVNVGATTAPVRV        70        80        90       100       110       120 120       130       140       150       160       170 m685.pepDYLQPAFDKAATVGTLFEPDYEALHRYNPQLVITGGPGAEAYEQLAKNATTIDLTVDNGN|||||||||||||||||||| |:|||:|||:||||||||||||||||||||||||||||| g685DYLQPAFDKAATVGTLFEPDCESLHRHNPQFVITGGPGAEAYEQLAKNATTIDLTVDNGN       130       140       150       160       170       180 180       190       200       210       220       230 m685.pepIRTSGEKQMETLARIFGKEARAAELKAQIDALFAQTREAAKGKGRGLVLSVTGNKVSAFG||||||||||||:||||||||:|||:||||||||| |||||||||||||||||||||||| g685IRTSGEKQMELLSRIFGKEARVAELNAQIDALFAQKREAAKGKGRGLVLSVTGNKVSAFG       190       200       210       220       230       240 240       250       260       270       280       290 m685.pepTQSRLASWIHGDIGLPPVDESLRNEGHGQPVSFEYIKEKNPDWIFIIDRTAAIGQEGPAA||||||||||||||||||||||||||||||||||||||||| |||||||||||||||||| g685TQSRLASWIHGDIGLPPVDESLRNEGHGQPVSFEYIKEKNPGWIFIIDRTAAIGQEGPAA       250       260       270       280       290       300 300       310       320       330       340       350 m685.pepVEVLDNALVRGTNAWKRKQIIVMPAANYIVAGGARQLIQAAEQLKAAFKKAEPVAAGKKX||||||||| ||||||||||||||||||||||||||||||||||||||:||||||| g685VEVLDNALVCGTNAWKRKQIIVMPAANYIVAGGARQLIQAAEQLKAAFEKAEPVAAQX       310       320       330       340       350The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2271>

a685.seq 1 TTGTTTTGCC GTATCGGGAA TTTTGCGTTT TGCGGCGTGG TTTCTGCAGG 51TTGTTTGCTT AATAATAAAC ATTCTTATTC GTATGCAAAG GAACCGCACA 101 CCGTGAAACCGCGTTTTTAT TGGGCAGCCT GCGCCGTCCT GCTGACCGCC 151 TGTTCGCCCG AACCTGCCGCCGAAAAAACT GTATCCGCCG CATCCGCATC 201 TGCCGCCACA CTGACCGTGC CGACCGCGCGGGGCGATGCC GTTGTGCCGA 251 AGAATCCCGA ACGCGTCGCC GTGTACGACT GGGCGGCGTTGGATACGCTG 301 ACCGAATTGG GTGTGAATGT GGGCGCAACC ACCGCGCCGG TGCGCGTGGA351 TTATTTGCAG CCTGCATTTG ACAAGGCGGC AACGGTGGGG ACGCTGTTCG 401AGCCCGATTA CGAAGCCCTG CACCGCTACA ATCCTCAGCT TGTCATTACC 451 GGCGGGCCGGGCGCGGAAGC GTATGAACAG TTGGCGAAAA ACGCGACCAC 501 CATAGATCTG ACGGTGGACAACGGCAATAT CCGCACCAGC GGCGAAAAGC 551 AGATGGAGAC CTTGGCGCGG ATTTTCGGCAAGGAAGCGCG CGCGGCGGAA 601 TTGAAGGCGC AGATTGACGC GCTGTTCGCC CAAACGCGCGAAGCCGCCAA 651 AGGCAAAGGA CGCGGGCTGG TGCTGTCGGT TACGGGCAAC AAGGTGTCCG701 CCTTCGGCAC GCAGTCGCGG TTGGCAAGTT GGATACACGG CGACATCGGC 751CTACCGCCTG TAGACGAATC TTTACGCAAC GAGGGGCACG GGCAGCCTGT 801 TTCCTTCGAATACATCAAAG AGAAAAACCC CGATTGGATT TTCATCATCG 851 ACCGTACCGC CGCCATCGGGCAGGAAGGGC CGGCGGCTGT CGAAGTATTG 901 GATAACGCGC TGGTACGCGG CACGAACGCTTGGAAGCGCA AGCAAATCAT 951 CGTCATGCCT GCCGCGAACT ACATTGTCGC GGGCGGCTCGCGGCAGTTGA 1001 TTCAGGCGGC GGAGCAGTTG AAGGAGGCGT TTGAAAAGGC AGAACCCGTT1051 GCGGCGGGGA AAGAGTAGThis corresponds to the amino acid sequence <SEQ ID 2272; ORF 685.a>:

a685.pep 1 LFCRIGNFAF CGVVSAGCLL NNKHSYSYAK EPHTVKPRFY WAACAVLLTA 51CSPEPAAEKT VSAASASAAT LTVPTARGDA VVPKNPERVA VYDWAALDTL 101 TELGVNVGATTAPVRVDYLQ PAFDKAATVG TLFEPDYEAL HRYNPQLVIT 151 GGPGAEAYEQ LAKNATTIDLTVDNGNIRTS GEKQMETLAR IFGKEARAAE 201 LKAQIDALFA QTREAAKGKG RGLVLSVTGNKVSAFGTQSR LASWIHGDIG 251 LPPVDESLRN EGHGQPVSFE YIKEKNPDWI FIIDRTAAIGQEGPAAVEVL 301 DNALVRGTNA WKRKQIIVMP AANYIVAGGS RQLIQAAEQL KEAFEKAEPV351 AAGKE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 685 shows 98.9% identity over a 355 aa overlap with a predicted ORF(ORF 685) from N. meningitidis:

m685/a685 98.9% identity in 355 aa overlap        10        20        30        40        50        60 m685.pepLFCRIGNFAFCGVVSAGCLLNNKHSYSYAKEPHTVKPRFYWAACAVLLTACSPEPAAEKT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a685LFCRIGNFAFCGVVSAGCLLNNKHSYSYAKEPHTVKPRFYWAACAVLLTACSPEPAAEKT        10        20        30        40        50        60        70        80        90       100       110       120 m685.pepVSAASASAATLTVPTARGDAVVPKNPERVAVYDWAALDTLTELGVNVGATTAPVRVDYLQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a685VSAASASAATLTVPTARGDAVVPKNPERVAVYDWAALDTLTELGVNVGATTAPVRVDYLQ        70        80        90       100       110       120       130       140       150       160       170       180 m685.pepPAFDKAATVGTLFEPDYEALHRYNPQLVITGGPGAEAYEQLAKNATTIDLTVDNGNIRTS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a685PAFDKAATVGTLFEPDYEALHRYNPQLVITGGPGAEAYEQLAKNATTIDLTVDNGNIRTS       130       140       150       160       170       180       190       200       210       220       230       240 m685.pepGEKQMETLARIFGKEARAAELKAQIDALFAQTREAAKGKGRGLVLSVTGNKVSAFGTQSR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a685GEKQMETLARIFGKEARAAELKAQIDALFAQTREAAKGKGRGLVLSVTGNKVSAFGTQSR       190       200       210       220       230       240       250       260       270       280       290       300 m685.pepLASWIHGDIGLPPVDESLRNEGHGQPVSFEYIKEKNPDWIFIIDRTAAIGQEGPAAVEVL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a685LASWIHGDIGLPPVDESLRNEGHGQPVSFEYIKEKNPDWIFIIDRTAAIGQEGPAAVEVL       250       260       270       280       290       300       310       320       330       340       350 m685.pepDNALVRGTNAWKRKQIIVMPAANYIVAGGARQLIQAAEQLKAAFKKAEPVAAGKKX|||||||||||||||||||||||||||||:||||||||||| ||:|||||||||:| a685DNALVRGTNAWKRKQIIVMPAANYIVAGGSRQLIQAAEQLKEAFEKAEPVAAGKEX       310       320       330       340       350The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2273>

g686.seq (partial) 1 ..AATTTCTCCT GCCGCGCCGA TGATGTTTTT GACGATATCTGCAGTGCCGT 51   TGAAGGCTTC ggcgGCATTG CCCGATCTGT CCAGCTCGGG GCTGTATCGG101   GTGGCGCGTT TGAATCCGTC GCCTACTCCT TGCGTCAGCA TAGCGCCGGC 151  ATTGTGGAAA CGGTCGGCAA GCCGTTGTCC GGTGCTGCGG TTGTCGGTCA 201  GGTTGAGGCG GATATTTTGG GCAACGCCTT TTATGTCGTA GCTGTATATA 251  TCCCTCGCGC CTTTGGGAGC GGGATAGCCG CCGCCCTGTG GCCCGTCATA 301  GCCGTCGGCG GGATGGTGTT CGTATCCGTC CCAATGGATG CGGTAAAGGC 351  TGAATCCGTC AACGGGACTA CCGGCTTCGT CAGAATCGGA ATGTGAThis corresponds to the amino acid sequence <SEQ ID 2274; ORF 686>:

g686.pep (partial) 1 ..NFSCRADDVF DDICSAVEGF GGIARSVQLG AVSGGAFESVAYSLRQHSAG 51   IVETVGKPLS GAAVVGQVEA DILGNAFYVV AVYIPRAFGS GIAAALWPVI101   AVGGMVFVSV PMDAVKAESV NGTTGFVRIG M*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2275>:

m686.seq.. 1 ATGATGTTGA AAAAATTCGT ACTCGGCGGT ATTGCCGCAT TGGTTTTGGC 51GGCCTGCGGC GGTTCGGAAG GCGGCAGCGG AGCGNNNNNN NNNNNNAATT 101 TCTCCTGCAGCGCCGATGAT GTTTTTAACG ATATCTGCAG TGCCGTTGAA 151 GGCTTCGGCG GCATTGCCCGATCTGTCCAG CTCGGGGCTG TATCGGGTGG 201 CGCGTTTGAA TCCGTCGCCT ACTCCTTGCGTCAGCATACT ACCGGCATTG 251 TGGAAACGGT CGGCAAGCCG TTGTCCGGTG CTGCGGTTGTCGGTCAGGTT 301 GAGGCGGATA TTTTGGGCAA CGCCTTTTAT GTCGTAGCTG TATATATCCC351 TCGCGCCTTT GGGAGCGGGA TAGCCGCCGC CCTGTGGCCC GTCATAGCCG 401TCGGCGGGAT GGTGTTCGTA TCCGTCCCAA TGGATGCGGT AAAGGCTAAA 451 TCCGTCAACGGGACTACCGG CTTCATCAGA ATCGGAATGT GAThis corresponds to the amino acid sequence <SEQ ID 2276; ORF 686>:

m686.pep 1 MMLKKFVLGG IAALVLAACG GSEGGSGAXX XXNFSCSADD VFNDICSAVE 51GFGGIARSVQ LGAVSGGAFE SVAYSLRQHT TGIVETVGKP LSGAAVVGQV 101 EADILGNAFYVVAVYIPRAF GSGIAAALWP VIAVGGMVFV SVPMDAVKAK 151 SVNGTTGFIR IGM*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 686 shows 95.4% identity over a 131 aa overlap with a predicted ORF(ORF 686) from N. gonorrhoeae

g686/m686 95.4% identity in 131 aa overlap                                      10        20        30 g686.pep                              NFSCRADDVFDDICSAVEGFGGIARSVQLG                              |||| |||||:||||||||||||||||||| m686LKKFVLGGIAALVLAACGGSEGGSGAXXXXNFSCSADDVFNDICSAVEGFGGIARSVQLG      10        20        30        40        50        60        40        50        60        70        80        90 g686.pepAVSGGAFESVAYSLRQHSAGIVETVGKPLSGAAVVGQVEADILGNAFYVVAVYIPRAFGS|||||||||||||||||::||||||||||||||||||||||||||||||||||||||||| m686AVSGGAFESVAYSLRQHTTGIVETVGKPLSGAAVVGQVEADILGNAFYVVAVYIPRAFGS      70        80        90       100       110       120       100       110       120       130 g686.pepGIAAALWPVIAVGGMVFVSVPMDAVKAESVNGTTGFVRIGMX|||||||||||||||||||||||||||:||||||||:||||| m686GIAAALWPVIAVGGMVFVSVPMDAVKAKSVNGTTGFIRIGMX     130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2277>

a686.seq (partial) 1 ..AATTTCTCCT GCCGCGCCGA TGATGTTTTT GACGATATCTGCAGTGCCGT 51   TGAAAGCTTC GGCGGCATTG CCCGATCTGT CCAGCTCGGG GCTGTATCGG101   GTGGCGCGTT TGAATCCGTC GCCTACTCCT TGCGTCAGCA TACTACCGGT 151  ATTGTGGAAA CGGTCGACAA GCCGTTGTCC GGTGCTGCGG TTGTCGGTCA 201  GGTTGAGGCG GATATTTTGG GCAACGCCTT TTATGTCGTA GCTGTATATA 251  TCCCTCGCGC CTTTGGGAGC GGGATAGCCG CCGCCCTGTG GCCCGTCATA 301  GCCGTCGGCG GGATGGTGTT CGTATCCGTC CCAATGGATG CGGTAAAGGC 351  TGAATCCGTC AACGGGACTA CCGGCTTCAT CAGAATCGGA ATGTGAThis corresponds to the amino acid sequence <SEQ ID 2278; ORF 686.a>:

a686.pep (partial) 1 ..NFSCRADDVF DDICSAVESF GGIARSVQLG AVSGGAFESVAYSLRQHTTG 51   IVETVDKPLS GAAVVGQVEA DILGNAFYVV AVYIPRAFGS GIAAALWPVI101   AVGGMVFVSV PMDAVKAESV NGTTGFIRIG M*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 686 shows 96.2% identity over a 131 aa overlap with a predicted ORF(ORF 686) from N meningitidis:

m686/a686 96.2% identity in 131 aa overlap      10        20        30        40        50        60 m686.pepLKKFVLGGIAALVLAACGGSEGGSGAXXXXNFSCSADDVFNDICSAVEGFGGIARSVQLG                              |||| |||||:|||||||:||||||||||| a686                              NFSCRADDVFDDICSAVESFGGIARSVQLG                                      10        20        30      70        80        90       100       110       120 m686.pepAVSGGAFESVAYSLRQHTTGIVETVGKPLSGAAVVGQVEADILGNAFYVVAVYIPRAFGS||||||||||||||||||||||||| |||||||||||||||||||||||||||||||||| a686AVSGGAFESVAYSLRQHTTGIVELVDKPLSGAAVVGQVEADILGNAFYVVAVYIPRAFGS        40        50        60        70        80        90     130       140       150       160 m686.pepGIAAALWPVIAVGGMVFVSVPMDAVKAKSVNGTTGFIRIGMX|||||||||||||||||||||||||||:|||||||||||||| a686GIAAALWPVIAVGGMVFVSVPMDAVKAESVNGTTGFIRIGMX       100       110       120       130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2279>

g687.seq 1 ATGAAATCCA GACACCTCGC CCTCGCCCTC GGCGTTGCCG CCCTGTTCGC 51CCTTGCCGCG TGCGACAGCA AAGTCCAAAC CAGCGTCCCC GCCGACAGCG 101 CGCCTGCCGCTTCGGCAGCC GCCGCCCCGG CAGGACTGGT CGAAGGGCAA 151 AACTACACCG TCCTTGCCAACCCGATTCCC CAACAGCAGG CAGGCAAGGT 201 TGAAGTGCTT GAGTTTTTCG GCTATTTTTGTCCGCACTGC GCCCGCCTcg 251 AACCTGTTTT GAGCAAACAC GCCAAGTCTT TTAAAGACGATATGTACCTG 301 CGTACCGAAC ACGTCGTCTG GCAGAAAGAA ATGCTGCCGC TGGCACGCct351 cGCCGCCGCC GTCGATATGG CTGCCGCCGA AAGCAAAGAT GTGGCGAACA 401GCCATATTTT CGATGCGATG GTCAACCAAA AAATCAAGCT GCAAGAGCCG 451 GAAGTCCTCAAAAAATGGCT GGGCGAACAa ACcgcctTTG ACGGCAAAAA 501 AGTCCTTGCC GCCTACGAATCCCCCGAAAG TCAGGCGCGC GCcggcAAAA 551 TGCAGGAGCT GACCGAAACC TTCCAAATCGACGGTACGCC CACGGTTATC 601 GTCGGCGGCA AATATAAAGT CGAATTTGCC GACTGGGAGTCCGGTATGAA 651 CACCATCGAC CTTTTGGCGG ACAAAGTACG TGAAGAACAA AAAGCCGCGC701 AGTAGThis corresponds to the amino acid sequence <2280 ID 724; ORF 687>:

g687.pep 1 MKSRHLALAL GVAALFALAA CDSKVQTSVP ADSAPAASAA AAPAGLVEGQ 51NYTVLANPIP QQQAGKVEVL EFFGYFCPHC ARLEPVLSKH AKSFKDDMYL 101 RTEHVVWQKEMLPLARLAAA VDMAAAESKD VANSHIFDAM VNQKIKLQEP 151 EVLKKWLGEQ TAFDGKKVLAAYESPESQAR AGKMQELTET FQIDGTPTVI 201 VGGKYKVEFA DWESGMNTID LLADKVREEQKAAQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2281>:

m687.seq 1 ATGAAATCCA GACACCTTGC CCTCgGCGTT GCCGCCCTGT TCGCCCTTGC 51CGCGTGCGAC AGCAAAGTCC AAACCAGCGT CCCCGCCGAC AGCGCGCCTG 101 CCGCTTCGGCAGCCGCCGCC CCGGCAGGGC TGGTCGAAGG GCAAAACTAT 151 ACCGTCCTTG CCAACCCGATTCCCCAACAG CAGGCAGGCA AAGTCGAAGT 201 CCTTGAGTTT TTCGGCTATT TCTGTCCGCACTGCGCCCAC CTCGAACCTG 251 TTTTAAGCAA ACACGCCAAG TCTTTTAAAG ACGATATGTACCTGCGTACC 301 GAACACGTCG TCTGGCAGAA AGAAATGCTG ACGCTGGCAC GCCTCGCCGC351 CGCCGTCGAT ATGGCTGCCG CCGACAGCAA AGATGTGGCG AACAGCCATA 401TTTTCGATGC GATGGTCAAC CAAAAAATCA AGCTGCAAAA TCCGGAAGTC 451 CTCAAAAAATGGCTGGGCGA ACAAACCGCC TTTGACGGCA AAAAAGTCCT 501 TGCCGCCTAC GAGTCCCCCGAAAGCCAGGC GCGCGCCGAC AAAATGCAGG 551 AGCTGACCGA AACCTTCCAA ATCGACGGTACGCCCACGGT TATCGTCGGC 601 GGTAAATATA AAGTTGAATT TGCCGACTGG GAGTCCGGTATGAACACCAT 651 CGACCTTTTG GCGGACAAAG TACGCGAAGA ACAAAAAGCC GCGCAGTAAThis corresponds to the amino acid sequence <SEQ ID 2282; ORF 687>:

m687.pep 1 MKSRHLALGV AALFALAACD SKVQTSVPAD SAPAASAAAA PAGLVEGQNY 51TVLANPIPQQ QAGKVEVLEF FGYFCPHCAH LEPVLSKHAK SFKDDMYLRT 101 EHVVWQKEMLTLARLAAAVD MAAADSKDVA NSHIFDAMVN QKIKLQNPEV 151 LKKWLGEQTA FDGKKVLAAYESPESQARAD KMQELTETFQ IDGTPTVIVG 201 GKYKVEFADW ESGMNTIDLL ADKVREEQKAAQ*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 687 shows 97.0% identity over a 234 aa overlap with a predicted ORF(ORF 687) from N. gonorrhoeae:

m687/g687 97.0% identity in 234 aa overlap           10        20        30        40        50 m687.pep MKSRHLAL--GVAALFALAACDSKVQTSVPADSAPAASAAAAPAGLVEGQNYTVLANPIP ||||||||  |||||||||||||||||||||||||||||||||||||||||||||||||| g687 MKSRHLALALGVAALFALAACDSKVQTSVPADSAPAASAAAAPAGLVEGQNYTVLANPIP         10        20        30        40        50        60 60        70        80        90       100       110 m687.pep QQQAGKVEVLEFFGYFCPHCAHLEPVLSKHAKSFKDDMYLRTEHVVWQKEMLTLARLAAA |||||||||||||||||||||:|||||||||||||||||||||||||||||| ||||||| g687 QQQAGKVEVLEFFGYFCPHCARLEPVLSKHAKSFKDDMYLRTEHVVWQKEMLPLARLAAA         70        80        90       100       110       120120       130       140       150       160       170 m687.pep VDMAAADSKDVANSHIFDAMVNQKIKLQNPEVLKKWLGEQTAFDGKKVLAAYESPESQAR ||||||:|||||||||||||||||||||:||||||||||||||||||||||||||||||| g687 VDMAAAESKDVANSHIFDAMVNQKIKLQEPEVLKKWLGEQTAFDGKKVLAAYESPESQAR        130       140       150       160       170       180180       190       200       210       220       230 m687.pep ADKMQELTETFQIDGTPTVIVGGKYKVEFADWESGMNTIDLLADKVREEQKAAQX | ||||||||||||||||||||||||||||||||||||||||||||||||||||| g687 AGKMQELTETFQIDGTPTVIVGGKYKVEFADWESGMNTIDLLADKVREEQKAAQX        190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2283>

a687.seq 1 ATGAAATCCA AACACCTCGC CCTCGGCGTT GCCGCCCTGT TCGCACTTGC 51CGCGTGCGAC AGCAAAGTCC AAACCAGCGT CCCCGCCGAC AGCGCGCCTG 101 CCGCTTCGGCAGCCGCCGCC CCGGCAGGGC TGGTCGAAGG GCAAAACTAT 151 ACTGTCCTTG CCAACCCGATTCCCCAACAG CAGGCAGGCA AAGTCGAAGT 201 CCTTGAGTTT TTCGGCTATT TCTGTCCGCACTGCGCCCAC CTCGAACCTG 251 TTTTAAGCAA ACACGCCAAG TCTTTTAAAG ACGATATGTACCTGCGTACC 301 GAACACGTCG TCTGGCAGAA AGAAATGCTG ACGCTCGCAC GCCTCGCCGC351 CGCCGTCGAT ATGGCTGCCG CCGACAGCAA AGATGTGGCG AACAGCCATA 401TTTTCGATGC GATGGTCAAC CAAAAAATCA AGCTGCAAGA GCCGGAAGTC 451 CTCAAAAAATGGCTGGGCGA ACAAACCGCC TTTGACGGCA AAAAAGTCCT 501 TGCCGCTTAC GAATCTCCCGAAAGCCAGGC GCGCGCCGAC AAAATGCAGG 551 AGCTGACCGA AACCTTCCAA ATCGACGGTACGCCCACGGT TATCGTCGGC 601 GGCAAATATA AAGTCGAATT TGCCGACTGG GAGTCCGGTATGAACACCAT 651 CGACCTTTTG GCGGACAAAG TACGCGAAGA ACAAAAAGCC GCGCACTAAThis corresponds to the amino acid sequence <SEQ ID 2284; ORF 687.a>:

a687.pep 1 MKSKHLALGV AALFALAACD SKVQTSVPAD SAPAASAAAA PAGLVEGQNY 51TVLANPIPQQ QAGKVEVLEF FGYFCPHCAH LEPVLSKHAK SFKDDMYLRT 101 EHVVWQKEMLTLARLAAAVD MAAADSKDVA NSHIFDAMVN QKIKLQEPEV 151 LKKWLGEQTA FDGKKVLAAYESPESQARAD KMQELTETFQ IDGTPTVIVG 201 GKYKVEFADW ESGMNTIDLL ADKVREEQKAAH*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 687 shows 98.7% identity over a 232 aa overlap with a predicted ORF(ORF 687) from N meningitidis:

m687/a687 98.7% identity in 232 aa overlap        10        20        30        40        50        60 m687.pepMKSRHLALGVAALFALAACDSKVQTSVPADSAPAASAAAAPAGLVEGQNYTVLANPIPQQ|||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||| a687MKSKHLALGVAALFALAACDSKVQTSVPADSAPAASAAAAPAGLVEGQNYTVLANPIPQQ        10        20        30        40        50        60        70        80        90       100       110       120 m687.pepQAGKVEVLEFFGYFCPHCAHLEPVLSKHAKSFKDDMYLRTEHVVWQKEMLTLARLAAAVD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a687QAGKVEVLEFFGYFCPHCAHLEPVLSKHAKSFKDDMYLRTEHVVWQKEMLTLARLAAAVD        70        80        90       100       110       120       130       140       150       160       170       180 m687.pepMAAADSKDVANSHIFDAMVNQKIKLQNPEVLKKWLGEQTAFDGKKVLAAYESPESQARAD||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| a687MAAADSKDVANSHIFDAMVNQKIKLQEPEVLKKWLGEQTAFDGKKVLAAYESPESQARAD       130       140       150       160       170       180       190       200       210       220       230 m687.pepKMQELTETFQIDGTPTVIVGGKYKVEFADWESGMNTIDLLADKVREEQKAAQX|||||||||||||||||||||||||||||||||||||||||||||||||||:| a687KMQELTETFQIDGTPTVIVGGKYKVEFADWESGMNTIDLLADKVREEQKAAHX       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2285>

g688.seq 1 GTGCTACACT AGACATCCCG ATTTGCACAG AAAGGTTCTC CCGTGAACAA 51AACCCTCATC CTCGCCCTTT CCGCCCTGTT CAGCCTGACC GCGTGCAGCG 101 TCGAACGCGTCTCGCTGTTT CCCTCCTACA AACTCAAAAT CATCCAAGGC 151 AACGAACTCG AACCGCGCGCCGTTGCCGCC CTGCGCCCCG GCATGACCAA 201 AGACCAAGTC CTGCTCCTGC TCGGCAGCCCCATACTGCGC GACGCTTTCC 251 ATACCGACCG CTGGGACTAT ACCTTCAACA CCTCCCGCAACGGCATCATC 301 AAAGAACGCA GCAACCTGAC CGTCTATTTT GAAAACGGCG TACTCGTCCG351 CACCGAAGGC GACGCCCTCC AAAATGCCGC CGAAGCCCTC CGCGCGAAAC 401AAAACGCAGA CAAACAATAAThis corresponds to the amino acid sequence <SEQ ID 2286; ORF 688>:

g688.pep 1 VLH*TSRFAQ KGSPVNKTLI LALSALFSLT ACSVERVSLF PSYKLKIIQG 51NELEPRAVAA LRPGMTKDQV LLLLGSPILR DAFHTDRWDY TFNTSRNGII 101 KERSNLTVYFENGVLVRTEG DALQNAAEAL RAKQNADKQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2287>:

m688.seq 1 GTGTTACACT ACCCATCCCG ATTTGCACAG AAAGGCATTT CCGTGAACAA 51AACCCTCATC CTCGCCCTTT CCGCCCTCCT CGGCCTTGCC GCGTGCAGTG 101 CCGAACGCGTTTCACTGTTC CCCTCGTACA AACTCAAAAT CATACAGGGC 151 AACGAACTCG AACCGCGCGCCGTTGCCGCC CTCCGCCCCG GCATGACCAA 201 AGACCAAGTC CTGCTCCTGC TCGGCAGCCCCATACTGCGC GACGCATTCC 251 ATACCGACCG CTGGGACTAT ACCTTCAACA CCTCCCGCAACGGCATCATC 301 AAAGAACGCA GCAATCTGAC CGTCTATTTT GAAAACGGCG TACTCGTCCG351 CACCGAAGGC GACGTCCTGC AAAACGCTGC CGAAGCCCTC AAAGACCGCC 401AAAACACAGA CAAACCATAAThis corresponds to the amino acid sequence <SEQ ID 2288; ORF 688>:

m688.pep 1 VLHYPSRFAQ KGISVNKTLI LALSALLGLA ACSAERVSLF PSYKLKIIQG 51NELEPRAVAA LRPGMTKDQV LLLLGSPILR DAFHTDRWDY TFNTSRNGII 101 KERSNLTVYFENGVLVRTEG DVLQNAAEAL KDRQNTDKP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 688 shows 90.6% identity over a 138 aa overlap with a predicted ORF(ORF 688) from N. gonorrhoeae:

m688/g688 90.6% identity in 138 aa overlap        10        20        30        40        50        60 m688.pepVLHYPSRFAQKGISVNKTLILALSALLGLAACSAERVSLFPSYKLKIIQGNELEPRAVAA|||  |||||||  ||||||||||||::|:|||:|||||||||||||||||||||||||| g688VLHXTSRFAQKGSPVNKTLILALSALFSLTACSVERVSLFPSYKLKIIQGNELEPRAVAA        10        20        30        40        50        60        70        80        90       100       110       120 m688.pepLRPGMTKDQVLLLLGSPILRDAFHTDRWDYTFNTSRNGIIKERSNLTVYFENGVLVRTEG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g688LRPGMTKDQVLLLLGSPILRDAFHTDRWDYTENTSRNGIIKERSNLTVYFENGVLVRTEG        70        80        90       100       110       120       130       140 m688.pep DVLQNAAEALKDRQNTDKPX |:||||||||: :||:||g688 DALQNAAEALRAKQNADKQX        130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2289>

a688.seq 1 GTGTTACACT ACCCATCCCG ATTTGCACAG AAAGGCATTT CCGTGAACAA 51AACCCTCATC CTCGCCCTTT CCGCCCTCCT CGGCCTTGCC GCGTGCAGCG 101 TCGAACGCGTTTCACTGTTC CCCTCGTACA AACTCAAAAT CATACAGGGC 151 AACGAACTCG AACCTCGCGCCGTCGCCTCC CTCCGCCCCG GTATGACCAA 201 AGACCAAGTC CTGCTCCTGC TCGGCAGCCCCATACTGCGC GACGCATTCC 251 ATACCGACCG CTGGGACTAT ACCTTCAACA CCTCCCGCAACGGCATCATC 301 AAAGACCGAA GCAATCTGAC CGTCTATTTT GAAAACGGCG TGCTCGTCCG351 CACCGAAGGC AACGCCCTGC AAAATGCCGC CGAAGCCCTC CGCGTAAAAC 401AAAACGCAGA CAAACAATAAThis corresponds to the amino acid sequence <SEQ ID 2290; ORF 688.a>:

a688.pep 1 VLHYPSRFAQ KGISVNKTLI LALSALLGLA ACSVERVSLF PSYKLKIIQG 51NELEPRAVAS LRPGMTKDQV LLLLGSPILR DAFHTDRWDY TFNTSRNGII 101 KDRSNLTVYFENGVLVRTEG NALQNAAEAL RVKQNADKQ*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 688 shows 93.5% identity over a 138 aa overlap with a predicted ORF(ORF 688) from N. meningitidis

m688/a688 93.5% identity in 138 aa overlap        10        20        30        40        50        60 m688.pepVLHYPSRFAQKGISVNKTLILALSALLGLAACSAERVSLFPSYKLKIIQGNELEPRAVAA|||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||: a688VLHYPSRFAQKGISVNKTLILALSALLGLAACSVERVSLFPSYKLKIIQGNELEPRAVAS        10        20        30        40        50        60        70        80        90       100       110       120 m688.pepLRPGMTKDQVLLLLGSPILRDAFHTDRWDYTFNTSRNGIIKERSNLTVYFENGVLVRTEG|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| a688LRPGMTKDQVLLLLGSPILRDAFHTDRWDYTENTSRNGIIKDRSNLTVYFENGVLVRTEG        70        80        90       100       110       120       130       140 m688.pep DVLQNAAEALKDRQNTDKPX ::||||||||: :||:||a688 NALQNAAEALRVKQNADKQX        130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2291>

g689.seq (partial) 1 ..TCTCCGCCCC TTCCTCCGAT GAGCGGAAAA CTGATGGCGGTTTTGATGGC 51   GGTACTGGTC GCGCTGATGC CGTTTTCCAT CGATGCCTAC CTGCCCGCGA101   TTCCCGAAAT GGCGCAGCCG CTGAACGCGG ATATCCACCG TATCGAATAG 151  AGTCTGAGTT TGTTTATGTT CGGCACGGCG TTCGGGCAAG TGGCCGGCGG 201  CGCGGTGTCC GACATCAAAG GGCGCAAACC CGTCGCCCTG ACCGGTTTGA 251  TTGTATATTG CCTTGCCGTT GCCGCCATCG TATTTGCTTC GAGTACCGAA 301  CAGCTCCTTA ACCTGCGTGC GGTACAGGCG TTCGGCGCAG GCATGGCTGT 351  AGTCATCGTc ggtgcgatgg tgcgcgatTA TTATTCCGGA CGCAAAGCCG 401  cgcAGATGTT TGCCCTTATC GGCATCATTC TGATGGTTGT GCCGCTGGCC 451  GCACCCATGG TCGGCGCATT GTTGCAGGGA TTGGGCGGAT GGCGGGCGAT 501  TTTCGTTTTC ttggcGgcgT ATTCGCCGGT GCTGCCCGGT TTGGTACAGT 551  ATTTCCTGCC CAATCCCGCC GTCGGCGGCA AAATCGGCAG GGATGTGTTC 601  GGGCTGGTGG CGGGGCGGTT CAAGCGCGTA TTGAAAACCC GTGCCGCGAT 651  GGGTtatCTG TTTTTTCAGG CATTCAGCTT CGGTTCGATG TTCGCCTTTC 701  TGACCGAATC TTCCTTCGTG TACCGGCAGC TCTACCACGT TACGCCGCAC 751  CGGTACGCAT GGGTGTTTGC ACTCAACATC ATCACGATGA TGTTTTTCAG 801  CCGCGTTACC GCGTGGCGGC TTAAAACCGG CGCGCATCCG CAAAGCATCC 851  TGCTGCGGGG GATTGTCGTC CAATTTGCCG CCAACCCGTC CCAACTCGCC 901  GCCGTGCTGT TTTTCGGGTT GCCCCCGTTT TGGCTGCCGG TCGCGTGCGT 951  GATGTTTTCC GTCGGTACGC AGGGCCTGGT CGGTGCGGAC ACGCAGGCAT 1001  GCTTTATGTC TTATTTCAAA GAAGAGGGCG GCAGCGCGAA CGCCGTGTCG 1051  GGTGTATTCC GGTCCTTAAT CGGCGCGGGC GTGGTCATGG CGGCAACCGT 1101  GATGGCGGCA ACCATGACCG CGTCCGCCTC TTGCGGCATT GCGCTTTTGT 1151  GGCTCTGCTC GCACAAGGCG TGGAAGGAAA ACGAAAAAAA GCGAATACTTThis corresponds to the amino acid sequence <SEQ ID 2292; ORF 689>:

g689.pep (partial) 1 ..SPPLPPMSGK LMAVLMAVLV ALMPFSIDAY LPAIPEMAQPLNADIHRIE* 51   SLSLFMFGTA FGQVAGGAVS DIKGRKPVAL TGLIVYCLAV AAIVFASSTE101   QLLNLRAVQA FGAGMAVVIV GAMVRDYYSG RKAAQMFALI GIILMVVPLA 151  APMVGALLQG LGGWRAIFVF LAAYSPVLPG LVQYFLPNPA VGGKIGRDVF 201  GLVAGRFKRV LKTRAAMGYL FFQAFSFGSM FAFLTESSFV YRQLYHVTPH 251  RYAWVFALNI ITMMFFSRVT AWRLKTGAHP QSILLRGIVV QFAANPSQLA 301  AVLFFGLPPF WLPVACVMFS VGTQGLVGAD TQACFMSYFK EEGGSANAVS 351  GVFRSLIGAG VVMAATVMAA TMTASASCGI ALLWLCSHKA WKENEKKRILThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2293>:

m689.seq 1 TTGTTAATCC ACTATATCGT TCCGGTTCGT CCGGTTTTGC CGGGGCTTTT 51GTTGCCGCCT GTTTGTGCCG GTGTGTTAAA ATTTTCCGTT TCCGCGTATT 101 GTGTTTTCCGCCGCCGGGCG GTTTGTTTGC GAATCGGACG AGAATTTATG 151 CCTTCTGCCC ATTATCCTGAAATGAGCGAA AAACTGATGG CGGTTTTGAT 201 GGCGATGCTG GTTACGCTGA TGCCGTTTTCCATCGATGCC TACCTGCCCG 251 CGATTCCCGA AATGGCGCAA TCGCTGAACG CGGATGTTCACCGCATCGAA 301 CAGAGTTTGA GTTTGTTTAT GTTCGGCACG GCGTTCGGAC AGGTGGTCGG351 CGGTTCGGTG TCCGACATCA AAGGGCGCAA ACCCGTCGCC CTGACCGGTT 401TGATTGTATA TTGCCTTGCC GTTGCCGCCA TCGTATTTGT TTCGAGTGCC 451 GAACAGCTCCTCAACCTGCG CGTCGTGCAG GCATTCGGTG CGGGCATGAC 501 TGTGGTCATC GTCGGCGCAATGGTGCGCGA TTATTATTCC GGACGCAAAG 551 CCGCCCAGAT GTTTGCCCTT ATCGGCATCATTTTGATGGT TGTGCCGCTG 601 GTCGCACCCA TGGTCGGCGC ATTGTTGCAG GGCTTGGGTGGCTGGCAGGC 651 GATTTTTGTT TTTCTGGCGG CGTATTCGCT GGTGCTGCTC GGTTTGGTAC701 AGTATTTCCT GCCCAAGCCC GCCGTCGGCG GCAAAATCGG ACGGGACGTG 751TTCGGGCTGG TGGCGGGGCG GTTCAAGCGC GTATTGAAAA CCCGTGCTGC 801 GATGGGTTATCTGTTTTTTC AGGCATTCAG CTTCGGTTCG ATGTTCGCCT 851 TTCTGACCGA ATCTTCCTTCGTGTACCAGC AGCTCTACCG TGTTACGCCT 901 CATCAATACG CTTGGGCGTT TGCACTCAACATCATCACGA TGATGTTTTT 951 CAACCGCGTT ACCGCGTGGC GGCTCAAAAC CGGCGTGCATCCGCAAAGCA 1001 TCCTGCTGTG GGGGATTGTC GTCCAGTTTG CCGCCAACCT GTCCCAACTC1051 GCCGCCGTGC TGTTTTTCGG GTTGCCCCCG TTTTGGCTGC TGGTCGCGTG 1101CGTGATGTTT TCCGTCGGTA CGCAGGGCTT GGTCGGTGCA AACACGCAGG 1151 CGTGTTTTATGTCCTATTTC AAAGAAGAGG GCGGCAGCGC AAACGCCGTA 1201 TTGGGTGTAT TCCAATCTTTAATCGGCGCG GGGGTGGGTA TGGCGGCGAC 1251 CTTCTTGCAC GACGGTTCGG CAACCGTGATGGCGGCAACG ATGACCGCGT 1301 CCACCTCTTG CGGCATTGCG CTTCTGTGGC TCTGCTCGCATCGTGCGTGG 1351 AAAGAAAACG GGCAAAGCGA ATACCTTTAAThis corresponds to the amino acid sequence <SEQ ID 2294; ORF 689>:

m689.pep 1 LLIHYIVPVR PVLPGLLLPP VCAGVLKFSV SAYCVFRRRA VCLRIGREFM 51PSAHYPEMSE KLMAVLMAML VTLMPFSIDA YLPAIPEMAQ SLNADVHRIE 101 QSLSLFMFGTAFGQVVGGSV SDIKGRKPVA LTGLIVYCLA VAAIVFVSSA 151EQLLNLRVVQ AFGAGMTVVI VGAMVRDYYS GRKAAQMFAL IGIILMVVPL 201 VAPMVGALLQGLGGWQAIFV FLAAYSLVLL GLVQYFLPKP AVGGKIGRDV 251 FGLVAGRFKR VLKTRAAMGYLFFQAFSFGS MFAFLTESSF VYQQLYRVTP 301 HQYAWAFALN IITMMFFNRV TAWRLKTGVHPQSILLWGIV VQFAANLSQL 351 AAVLFFGLPP FWLLVACVMF SVGTQGLVGA NTQACFMSYFKEEGGSANAV 401 LGVFQSLIGA GVGMAATFLH DGSATVMAAT MTASTSCGIA LLWLCSHRAW451 KENGQSEYL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 689 shows 88.0% identity over a 408 aa overlap with a predicted ORF(ORF 689) from N. gonorrhoeae:

m689/a689 88.0% identity in 408 aa overlap       30        40        50        60        70        80 m689.pepCAGVLKFSVSAYCVFRRRAVCLRIGREFMPSAHYPEMSEKLMAVLMAMLVTLMPFSIDAY                              |   | || ||||||||:||:||||||||| g689                              SPPLPPMSGKLMAVLMAVLVALMPFSIDAY                                      10        20        30       90       100       110       120       130       140 m689.pepLPAIPEMAQSLNADVHRIEQSLSLFMFGTAFGQVVGGSVSDIKGRKPVALTGLIVYCLAV||||||||| ||||:|||| ||||||||||||||:||:|||||||||||||||||||||| g689LPAIPEMAQPLNADIHRIEXSLSLFMFGTAFGQVAGGAVSDIKGRKPVALTGLIVYCLAV        40        50        60        70        80        90      150       160       170       180       190       200 m689.pepAAIVFVSSAEQLLNLRVVQAFGAGMTVVIVGAMVRDYYSGRKAAQMFALIGIILMVVPLV|||||:||:|||||||:||||||||:|||||||||||||||||||||||||||||||||: g689AAIVFASSTEQLLNLRAVQAFGAGMAVVIVGAMVRDYYSGRKAAQMFALIGIILMVVPLA       100       110       120       130       140       150      210       220       230       240       250       260 m689.pepAPMVGALLQGLGGWQAIFVFLAAYSLVLLGLVQYFLPKPAVGGKIGRDVFGLVAGRFKRV||||||||||||||:|||||||||| || ||||||||:|||||||||||||||||||||| g689APMVGALLQGLGGWRAIFVFLAAYSPVLPGLVQYFLPNPAVGGKIGRDVFGLVAGRFKRV       160       170       180       190       200       210      270       280       290       300       310       320 m689.pepLKTRAAMGYLFFQAFSFGSMFAFLTESSFVYQQLYRVTPHQYAWAFALNIITMMFFNRVT|||||||||||||||||||||||||||||||:|||:||||:|||:|||||||||||:||| g689LKTRAAMGYLFFQAFSFGSMFAFLTESSFVYRQLYHVTPHRYAWVFALNIITMMFFSRVT       220       230       240       250       260       270      330       340       350       360       370       380 m689.pepAWRLKTGVHPQSILLWGIVVQFAANLSQLAAVLFFGLPPFWLLVACVMFSVGTQGLVGAN|||||||:||||||| ||||||||| |||||||||||||||| ||||||||||||||||: g689AWRLKTGAHPQSILLRGIVVQFAANPSQLAAVLFFGLPPFWLPVACVMFSVGTQGLVGAD       280       290       300       310       320       330      390       400       410       420       430       440 m689.pepTQACFMSYFKEEGGSANAVLGVFQSLIGAGVGMAATFLHDGSATVMAATMTASTSCGIAL||||||||||||||||||| |||:||||||| ||||        |||||||||:|||||| g689TQACFMSYFKEEGGSANAVSGVFRSLIGAGVVMAAT--------VMAATMTASASCGIAL       340       350       360               370       380      450       460 m689.pep LWLCSHRAWKENGQSEYLX ||||||:||||| ::: | g689LWLCSHKAWKENEKKRIL      390       400The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2295>

a689.seq 1 TTGTTAATCC ACTATATCGT TCCGGTTCGT CCGGTTTTGC CGGGGCTTTT 51GTTGCCGCCT GTTTGTGCCG GTGTGTTAAA ATTTTCCGTT TCCGCGTATT 101 GTGTTTTCCGCCGCCGGGCG GTTTGTTTGC GAATCGGACG AGAATTTATG 151 CCTTCTGCCC ATTATCCTGAAATGAGCGAA AAACTGATGG CGGTTTTGAT 201 GGCGATGCTG GTTACGCTGA TGCCGTTTTCCATCGATGCC TACCTGCCCG 251 CGATTCCCGA AATGGCGCAG TCGCTGAACG CGGATGTCCACCGCATCGAA 301 CAGAGCCTGA GTTTGTTTAT GTTCGGCACG GCGTTCGGAC AGGTGGTCGG351 CGGTTCGGTG TCCGACATCA AAGGGCGCAA ACCCGTCGCG CTGACCGGAC 401TGGCCGTCTA CTGCCTTGCC GTTGCCGCCA TCGTATTTGC TTCGAGTGCC 451 GAACAGCTCCTCAACCTGCG CGTCGTGCAG GCATTCGGTG CGGGCATGAC 501 TGTGGTCATC GTCGGCGCAATGGTGCGCGA TTATTATTCC GGACGCAAAG 551 CCGCCCAGAT GTTTGCCCTT ATCGGCATCATTTTGATGGT TGTGCCGCTG 601 GTCGCACCCA TGGTCGGCGC ATTGTTGCAG GGCTTGGGTGGCTGGCAGGC 651 GATTTTTGTT TTTCTGGCGG CGTATTCGCT GGTGCTGCTC GGTTTGGTAC701 AGTATTTCCT GCCCAAGCCC GCCGTCGGCG GCAAAATCGG CAGGGATGTG 751TTCGGGCTGG TGGCTGGGCG GTTCAAACGC GTATTGAAAA CCCGTGCCGC 801 GATGGGTTATCTGTTTTTTC AGGCATTCAG CTTCGGTTCG ATGTTCGCCT 851 TTCTGACCGA ATCTTCCTTCGTGTACCAGC AGCTCTACCA CGTTACGCCG 901 CACCAGTACG CTTGGGCGTT TGCACTCAACATCATCACGA TGATGTTTTT 951 CAACCGTATT ACCGCGTGGC GGCTCAAAAC CGGCGTGCATCCGCAAAGCA 1001 TCCTGCTGTG GGGGATTGTC GTCCAGTTTG CCGCCAACCT GTCCCAACTC1051 GCCGCCGTGC TGTTTTTCGG GTTGCCCCCG TTTTGGCTGC TGGTCGCGTG 1101CGTGATGTTT TCCGTCGGTA CGCAGGGCTT GGTCGGTGCA AACACGCAGG 1151 CGTGTTTTATGTCCTATTTC AAAGAAGAGG GCGGCAGCGC AAACGCCGTA 1201 TTGGGTGTAT TCCAATCTTTAATCGGCGCG GGGGTGGGTA TGGCGGCGAC 1251 CTTCTTGCAC GACGGTTCGG CAACCGTGATGGCGGCAACC ATGACCGCGT 1301 CTACCTCTTG CGGCATTGCG CTTTTGTGGC TCTGCTCGCATCGTGCGTGG 1351 AAAGAAAACG GGCAAAGCGA ATACCTTTAAThis corresponds to the amino acid sequence <SEQ ID 2296; ORF 689.a>:

a689.pep 1 LLIHYIVPVR PVLPGLLLPP VCAGVLKFSV SAYCVFRRRA VCLRIGREFM 51PSAHYPEMSE KLMAVLMAML VTLMPFSIDA YLPAIPEMAQ SLNADVHRIE 101 QSLSLFMFGTAFGQVVGGSV SDIKGRKPVA LTGLAVYCLA VAAIVFASSA 151EQLLNLRVVQ AFGAGMTVVI VGAMVRDYYS GRKAAQMFAL IGIILMVVPL 201 VAPMVGALLQGLGGWQAIFV FLAAYSLVLL GLVQYFLPKP AVGGKIGRDV 251 FGLVAGRFKR VLKTRAAMGYLFFQAFSFGS MFAFLTESSF VYQQLYHVTP 301 HQYAWAFALN IITMMFFNRI TAWRLKTGVHPQSILLWGIV VQFAANLSQL 351 AAVLFFGLPP FWLLVACVMF SVGTQGLVGA NTQACFMSYFKEEGGSANAV 401 LGVFQSLIGA GVGMAATFLH DGSATVMAAT MTASTSCGIA LLWLCSHRAW451 KENGQSEYL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 689 shows 99.1% identity over a 459 aa overlap with a predicted ORF(ORF 689) from N. meningitidis:

m689/a689 99.1% identity in 459 aa overlap        10        20        30        40        50        60 m689.pepLLIHYIVPVRPVLPGLLLPPVCAGVLKFSVSAYCVFRRRAVCLRIGREFMPSAHYPEMSE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a689LLIHYIVPVRPVLPGLLLPPVCAGVLKFSVSAYCVFRRRAVCLRIGREFMPSAHYPEMSE        10        20        30        40        50        60        70        80        90       100       110       120 m689.pepKLMAVLMAMLVTLMPFSIDAYLPAIPEMAQSLNADVHRIEQSLSLFMFGTAFGQVVGGSV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a689KLMAVLMAMLVTLMPFSIDAYLPAIPEMAQSLNADVHRIEQSLSLFMFGTAFGQVVGGSV        70        80        90       100       110       120       130       140       150       160       170       180 m689.pepSDIKGRKPVALTGLIVYCLAVAAIVFVSSAEQLLNLRVVQAFGAGMTVVIVGAMVRDYYS|||||||||||||| |||||||||||:||||||||||||||||||||||||||||||||| a689SDIKGRKPVALTGLAVYCLAVAAIVFASSAEQLLNLRVVQAFGAGMTVVIVGAMVRDYYS       130       140       150       160       170       180       190       200       210       220       230       240 m689.pepGRKAAQMFALIGIILMVVPLVAPMVGALLQGLGGWQAIFVFLAAYSLVLLGLVQYFLPKP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a689GRKAAQMFALIGIILMVVPLVAPMVGALLQGLGGWQAIFVFLAAYSLVLLGLVQYFLPKP       190       200       210       220       230       240       250       260       270       280       290       300 m689.pepAVGGKIGRDVFGLVAGRFKRVLKTRAAMGYLFFQAFSFGSMFAFLTESSFVYQQLYRVTP||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||| a689AVGGKIGRDVFGLVAGRFKRVLKTRAAMGYLFFQAFSFGSMFAFLTESSFVYQQLYHVTP       250       260       270       280       290       300       310       320       330       340       350       360 m689.pepHQYAWAFALNIITMMFFNRVTAWRLKTGVHPQSILLWGIVVQFAANLSQLAAVLFFGLPP|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||| a689HQYAWAFALNIITMMFFNRITAWRLKTGVHPQSILLWGIVVQFAANLSQLAAVLFFGLPP       310       320       330       340       350       360       370       380       390       400       410       420 m689.pepFWLLVACVMFSVGTQGLVGANTQACFMSYFKEEGGSANAVLGVFQSLIGAGVGMAATFLH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a689FWLLVACVMFSVGTQGLVGANTQACFMSYFKEEGGSANAVLGVFQSLIGAGVGMAATFLH       370       380       390       400       410       420       430       440       450       460 m689.pepDGSATVMAATMTASTSCGIALLWLCSHRAWKENGQSEYLX|||||||||||||||||||||||||||||||||||||||| a689DGSATVMAATMTASTSCGIALLWLCSHRAWKENGQSEYLX       430       440       450       460The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2297>

g690.seq (partial) 1 ATGAAAAACA AAACGTCATC ACTTCCCTTA TGGCTTGCCGCAATCATGCT 51 GGCCGCGCGT TCCCCGAGCA AAGAAGATAA AACGAAAGAA AACGGCGCAT 101CCGCCGCTTC GTCTTCCGCG TCATCGGCTT CTTCCCAAAC CGATTTGCAA 151 CCGGCCGCATCCGCCCCTGA TAACGTCAAG CAGGCAGAAA GCGCGCCACT 201 GTGAAATTGC ACCGGCCTGCACCCCGCCGC CGGCATTGGC GATCTCATAC 251 AGCAAATCGC CGAACACATC GACTCGGACTGTCTGTTTGC CCTTTCCCAT 301 AACGAACTGG AAACCCGTTT CGGCTTACCC GGCGGCGGCTATGACAACAT 351 ACAGCGGctG CTgtttCCCG ACATCCGCCC TGAAGATCCC GACTACCATC401 AGAAAATCAT GCTGGCAATC GAAGACTTGC GTTACGGAAC GCGCACCATC 451AGccgGCAGG CACAAGATGC CATAATGGAA CAGGAACGCC gcctccGaGa 501 agCGACGCTGATGCTGACAC AGGGCAGTCA AAAAACCCGC GGaCAAGGCG 551 AGGAACCGAA ACGCGCACGTTATTTTGAAG TTTCGGCAAC ATCtgCCtaT 601 TTgaaccggC ACAAcaacGG ACTTggcgGCAATTTCCAAT ACATCGGCCA 651 ATTGCCCGGC TATCTGAAAA TGCACGGAGA AATGCTTGAAAACCAATCAC 701 TCTTCCGGCT GTCCAACCGT GAACGCAATC CCGACAAACC GTTTTTAGAC751 ATCCATTTTG ACGAAAATGG CAAAATCACG CGTATTGTCG TTTACGAAAA 801AAATATCTAT...This corresponds to the amino acid sequence <SEQ ID 2298; ORF 690>:

g690.pep (partial) 1 MKNKTSSLPL WLAAIMLAAR SPSKEDKTKE NGASAASSSASSASSQTDLQ 51 PAASAPDNVK QAESAPL*NC TGLHPAAGIG DLIQQIAEHI DSDCLFALSH 101NELETRFGLP GGGYDNIQRL LFPDIRPEDP DYHQKIMLAI EDLRYGTRTI 151 SRQAQDAIMEQERRLREATL MLTQGSQKTR GQGEEPKRAR YFEVSATSAY 201 LNRHNNGLGG NFQYIGQLPGYLKMHGEMLE NQSLFRLSNR ERNPDKPFLD 251 IHFDENGKIT RIVVYEKNIY ...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2299>:

m690.seq.. 1 ATGAAAAACA AAACCTCATC ACTTCTCTTA TGGCTTACCG CAATCATGCT 51GACCGCGTGT TCTCCGAGCA AAGACGATAA AACCAAAGAA GTCGGTGCAT 101 CCGCTGCTTCGTCCTCCGCG TCATCAGCTC CTTCCCAAAC CGATTTGCAA 151 CCGACCGCAT CCGCCCCTGATAACGTCAAG CAGGCAGAAA GCGCGCCGCC 201 GTCAAATTGC ACCAGCCTGC ACCCCGCCACCGGCATTGAC GATCTCATGC 251 AGCAAATCGC CGAACACATT GACTCGGACT GTCTGTTTGCCCTTTCCCAT 301 CACGAACTGG AAACCCGTTT CGGCTTACCC GACGGTGGCT ATGACAACAT351 ACAGCGGCTG CTGTTTCCCG ACATCCGCCC TGAAGATCCC GACTACCATC 401AGAAAATCAT ACTGGCAATT GAAGACTTGC GTTACGGAAA GCGCACGATC 451 AGCCGGCAGGCACAAAATGC CTTGATGGAA CAGGAACGCC GCCTCCGAGA 501 AGCGACGCTG TTGCTGATACAGGGCAGTCA AGAAACCCGC GGACAAGGCG 551 AGGAGCCGAA ACGCACGCGT TATTTTGAAGTTTCGGCAAC CCCTGCCTAT 601 TCGAGCCGGC ACAACAACGG ACTTGGCGGC AATTTCCAATACATCAGCCA 651 ATTGCCCGGC TATCTGAAAA TACACGGAGA AATGCTTGAA AACCAATCAC701 TCTTCCGGCT GTCCAACCGT GAACGCAATC CCGACAAACC GTTTTTAGAC 751ATCCATTTTG ACGAAAATGG CAAAATCACG CGTATTGTCG TTTACGAAAA 801 AAACATCTACTTCAATCCAA ACACGGGGCG AATATAAThis corresponds to the amino acid sequence <SEQ ID 2300; ORF 690>:

m690.pep 1 MKNKTSSLLL WLTAIMLTAC SPSKDDKTKE VGASAASSSA SSAPSQTDLQ 51PTASAPDNVK QAESAPPSNC TSLHPATGID DLMQQIAEHI DSDCLFALSH 101 HELETRFGLPDGGYDNIQRL LFPDIRPEDP DYHQKIILAI EDLRYGKRTI 151 SRQAQNALME QERRLREATLLLIQGSQETR GQGEEPKRTR YFEVSATPAY 201 SSRHNNGLGG NFQYISQLPG YLKIHGEMLENQSLFRLSNR ERNPDKPFLD 251 IHFDENGKIT RIVVYEKNIY FNPNTGRI*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 690 shows 89.3% identity over a 408 aa overlap with a predicted ORF(ORF 690) from N. gonorrhoeae:

m690/g690 89.3% identity in 408 aa overlap        10        20        30        40        50        60 m690.pepMKNKTSSLLLWLTAIMLTACSPSKDDKTKEVGASAASSSASSAPSQLDLQPTASAPDNVK|||||||| |||:||||:| ||||:||||| |||||||||||| |||||||:|||||||| g690MKNKTSSLPLWLAAIMLAARSPSKEDKTKENGASAASSSASSASSQLDLQPAASAPDNVK        10        20        30        40        50        60        70        80        90       100       110       120 m690.pepQAESAPPSNCTSLHPATGIDDLMQQIAEHIDSDCLFALSHHELETRFGLPDGGYDNIQRL||||||  |||:||||:|| ||:|||||||||||||||||:||||||||| ||||||||| g690QAESAPLXNCTGLHPAAGIGDLIQQIAEHIDSDCLFALSHNELETRFGLPGGGYDNIQRL        70        80        90       100       110       120       130       140       150       160       170       180 m690.pepLFPDIRPEDPDYHQKIILAIEDLRYGKRTISRQAQNALMEQERRLREATLLLIQGSQETR||||||||||||||||:||||||||| ||||||||:|:||||||||||||:| ||||:|| g690LFPDIRPEDPDYHQKIMLAIEDLRYGTRTISRQAQDAIMEQERRLREATLMLTQGSQKTR       130       140       150       160       170       180       190       200       210       220       230       240 m690.pepGQGEEPKRTRYFEVSATPAYSSRHNNGLGGNFQYISQLPGYLKIHGEMLENQSLFRLSNR||||||||:|||||||| || :|||||||||||||:|||||||:|||||||||||||||| g690GQGEEPKRARYFEVSATSAYLNRHNNGLGGNFQYIGQLPGYLKMHGEMLENQSLFRLSNR       190       200       210       220       230       240       250       260       270      279 m690.pepERNPDKPFLDIHFDENGKITRIVVYEKNIYFNPNTGRIX ||||||||||||||||||||||||||||||g690 ERNPDKPFLDIHFDENGKITRIVVYEKNIY        250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2301>

a690.seq 1 ATGAAAAACA AAACCTCATC ACTTCTCTTA TGGCTTGCCG CAATGATGCT 51GACCGCGTGT TCCCCGAGCA AAGAAGATAA AACGAAAGAA AACGGCGCAT 101 CCGCCGCCTCGTCCACGGCA TCCGCCGCTT CGTCTTCCGC GCCCCAAACC 151 GATTTGCAAC CGGCCGCATCCGCCCCTGAT AACGTCAAGC AGGCAGAAAG 201 CGTGCCGCCG TCAAATTGCA CCGACCTGCACCCCGCCACC GGCATTGACG 251 ATCTCATGCA GCAAATCGCC GAACACATTG ACTCGGACTGTCTGTTTGCC 301 CTTTCCCATC ACGAACTGGA AACCCGTTTC GGCTTACCCG GCGGCGGCTA351 TGACAACATA CAGCGGCTGC TGTTTCCCGA CATCCGCCCT GAAGATCCCG 401ACTACCATCA GAAAATCATA CTGGCAATTG AAGACTTGCG TTACGGAAAG 451 CGCACGATCAGCCGGCAGGC ACAAGATGCC TTGATGGAAC AGGAACGCCG 501 CCTCCGAGAA GCGACGCTGTTGCTGATACA GGGCAGTCAA GAAACCCGCG 551 GACAAGGCGA GGAGCCGAAA CGCACGCGTTATTTTGAAGT TTCGGCAACC 601 CCTGCCTATT CGAGCCGGCA CAACAACGGA CTTGGCGGCAATTTCCAATA 651 CATCGGCCAA TTGCCCGGCT ATCTGAAAAT ACACGGAGAA ATGCTTGAAA701 ACCAATCACT CTTCCGGCTG TCCAACCGTG AACGCAATCC CGACAAACCG 751TTTTTAGACA TCCATTTTGA CGAAAATGGC AAAATCACGC GTATTGTCGT 801 TTACGAAAAAAACATCTACT TCAATCCAAA CTTGGGGCGA AGATAAThis corresponds to the amino acid sequence <SEQ ID 2302; ORF 690.a>:

a690.pep 1 MKNKTSSLLL WLAAMMLTAC SPSKEDKTKE NGASAASSTA SAASSSAPQT 51DLQPAASAPD NVKQAESVPP SNCTDLHPAT GIDDLMQQIA EHIDSDCLFA 101 LSHHELETRFGLPGGGYDNI QRLLFPDIRP EDPDYHQKII LAIEDLRYGK 151 RTISRQAQDA LMEQERRLREATLLLIQGSQ ETRGQGEEPK RTRYFEVSAT 201 PAYSSRHNNG LGGNFQYIGQ LPGYLKIHGEMLENQSLFRL SNRERNPDKP 251 FLDIHFDENG KITRIVVYEK NIYFNPNLGR R*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 690 shows 93.9% identity over a 280 aa overlap with a predicted ORF(ORF 690) from N. meningitidis:

m690/a690 93.9% identity in 280 aa overlap        10        20        30        40           50 m690.pepMKNKTSSLLLWLTAIMLTACSPSKDDKTKEVGASAASSSASSAPS---QTDLQPTASAPD||||||||||||:|:|||||||||:||||| |||||||:||:| |   ||||||:||||| a690MKNKTSSLLLWLAAMMLTACSPSKEDKTKENGASAASSTASAASSSAPQTDLQPAASAPD        10        20        30        40        50        60 60        70        80        90       100       110 m690.pepNVKQAESAPPSNCTSLHPATGIDDLMQQIAEHIDSDCLFALSHHELETRFGLPDGGYDNI|||||||:||||||:|||||||||||||||||||||||||||||||||||||| |||||| a690NVKQAESVPPSNCTDLHPATGIDDLMQQIAEHIDSDCLFALSHHELETRFGLPGGGYDNI        70        80        90       100       110       120120       130       140       150       160       170 m690.pepQRLLFPDIRPEDPDYHQKIILAIEDLRYGKRTISRQAQNALMEQERRLREATLLLIQGSQ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||| a690QRLLFPDIRPEDPDYHQKIILAIEDLRYGKRTISRQAQDALMEQERRLREATLLLIQGSQ       130       140       150       160       170       180180       190       200       210       220       230 m690.pepETRGQGEEPKRTRYFEVSATPAYSSRHNNGLGGNFQYISQLPGYLKIHGEMLENQSLFRL||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||| a690ETRGQGEEPKRTRYFEVSATPAYSSRHNNGLGGNFQYIGQLPGYLKIHGEMLENQSLFRL       190       200       210       220       230       240240       250       260       270       279 m690.pepSNRERNPDKPFLDIHFDENGKITRIVVYEKNIYFNPNTGRIX||||||||||||||||||||||||||||||||||||| || a690SNRERNPDKPFLDIHFDENGKITRIVVYEKNIYFNPNLGRRX       250       260       270       280The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2303>

g691.seq 1 GTGCCGCTGC CTGCTCCCTG CCGTTTTGCC AAACCTGCCG CCTCTTTTTT 51AAGTATGGCT TTGCTTTCCT GCCAGCTTTC CCACGCCGCC ACGGCTTATA 101 TCCCCCCGAACGATTTTCAA CCGAACTGCG ACATACGCCG GCTCGGGCTG 151 ACACAGGGTC AGCACAATGAGCTGCGTAAA ATCCGCGCCG CCTTCAAAAT 201 GGCGGGCGAC AGGGCGCGTT TGAAGGTTATGCATTCCGAA CACAGCCGCC 251 GCCGCTCTGT CGTCGAAATC ATTTCTTCGG ATGTTTTTAATCGGAACGAG 301 GCGCGCGATT ATGTCGAAAG CCGCTACCAC TCCAGCATGG ATTTTGCGGT351 GGACGAATTG GAAATCCAAC ACCGCTTCTT CCATATTCTC ACACCGCAAC 401AGCAGCAAAT GTGGCTTTCT TCCTGCCTCA AATAAThis corresponds to the amino acid sequence <SEQ ID 2304; ORF 691>:

g691.pep 1 VPLPAPCRFA KPAASFLSMA LLSCQLSHAA TAYIPPNDFQ PNCDIRRLGL 51TQGQHNELRK IRAAFKMAGD RARLKVMHSE HSRRRSVVEI ISSDVFNRNE 101 ARDYVESRYHSSMDFAVDEL EIQHRFFHIL TPQQQQMWLS SCLK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2305>:

m691.seq 1 GTGCCACTGC CTGCTCCCTG CCGTTTTGCC AAACCTGCCG CCTCTTTTTT 51AAGTATGGCT TTGCTTTCCT GTCAGCTTTC CCACGCCGCC ACGGCTTATA 101 TCCCCCCGAACGATTTTCAA CCGAACTGCG ACATACGCCG ACTCGGGCTG 151 ACCCAAAGTC AGCACAATGAGCTGCGTAAA ATCCGCACCG CCTTCAAAAT 201 GGCGGGCGAC AGGGCGCGTT TGAAGGTTATGCATTCCGAA CACAGCCGCC 251 GCCGGTCTGT CGTCGAAATC ATTTCCTCGG ATGTTTTTAATCGGAACGAG 301 GCGCGCGATT ATGTCGAAAG CCGCTATTTG TCCGGTATGG ATTTTGCGGT351 GGACGAATTG GAAATCCAAC ACCGGTTCTT CCATATCCTC ACACCGCAAC 401AGCAGCAAAT GTGGCTTTCT TCCTGCCTCA AATAAThis corresponds to the amino acid sequence <SEQ ID 2306; ORF 691>:

m691.pep 1 VPLPAPCRFA KPAASFLSMA LLSCQLSHAA TAYIPPNDFQ PNCDIRRLGL 51TQSQHNELRK IRTAFKMAGD RARLKVMHSE HSRRRSVVEI ISSDVFNRNE 101 ARDYVESRYLSGMDFAVDEL EIQHRFFHIL TPQQQQMWLS SCLK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 691 shows 97.2% identity over a 144 aa overlap with a predicted ORF(ORF 691) from N. gonorrhoeae:

m691/g691 97.2% identity in 144 aa overlap        10        20        30        40        50        60 m691.pepVPLPAPCRFAKPAASFLSMALLSCQLSHAATAYIPPNDFQPNCDIRRLGLTQSQHNELRK||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||| g691VPLPAPCRFAKPAASFLSMALLSCQLSHAATAYIPPNDFQPNCDIRRLGLTQGQHNELRK        10        20        30        40        50        60        70        80        90       100       110       120 m691.pepIRTAFKMAGDRARLKVMHSEHSRRRSVVEIISSDVFNRNEARDYVESRYLSGMDFAVDEL||:|||||||||||||||||||||||||||||||||||||||||||||| |:|||||||| g691IRAAFKMAGDRARLKVMHSEHSRRRSVVEIISSDVFNRNEARDYVESRYHSSMDFAVDEL        70        80        90       100       110       120       130       140 m691.pep EIQHRFFHILTPQQQQMWLSSCLKX||||||||||||||||||||||||| g691 EIQHRFFHILTPQQQQMWLSSCLKX       130       140The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2307>

a691.seq 1 GTGCCACTGC NTGCTCCCTG CCGTTTTGCC AAACCTGCCG CCTCTTTTTT 51AAGTATGGCT TTGCTTTCCT GCCAGCTTTC CCACGCCGCC ACGGCTTATA 101 TCCCCCTGAACGATTTTCAA CCGAACTGCG ACATACGCCG GCTCGGACTG 151 ACACAGGGTC AGCACAATGAACTGCGTAAA ATCCGCGCCG CCTTCAAAAT 201 GGCGGGCGAC AGGGCGCGTT TGAAGGTTATGCATTCCGAA CACAGCCGCC 251 GTCGGTCTGT CGTCGAAATC ATTTCCTCGG ATGTTTTTAATCGGAACGAG 301 GCGCGCGATT ATGTCGAAAG CCGCTATTTG TCCGGTATGG ATTTTGCGGT351 GGACGAATTG GAAATCCAAC ACCGGTTCTT CCATATCCTC ACACCGCAAC 401AGCAGCAAAT GTGGCTTTCT TCCTGCCTCA AATAAThis corresponds to the amino acid sequence <SEQ ID 2308; ORF 691.a>:

a691.pep 1 VPLXAPCRFA KPAASFLSMA LLSCQLSHAA TAYIPLNDFQ PNCDIRRLGL 51TQGQHNELRK IRAAFKMAGD RARLKVMHSE HSRRRSVVEI ISSDVFNRNE 101 ARDYVESRYLSGMDFAVDEL EIQHRFFHIL TPQQQQMWLS SCLK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 691 shows 97.2% identity over a 144 aa overlap with a predicted ORF(ORF 691) from N. meningitidis:

m691/a691 97.2% identity in 144 aa overlap        10        20        30        40        50        60 m691.pepVPLPAPCRFAKPAASFLSMALLSCQLSHAATAYIPPNDFQPNCDIRRLGLTQSQHNELRK||| ||||||||||||||||||||||||||||||| ||||||||||||||||:||||||| a691VPLXAPCRFAKPAASFLSMALLSCQLSHAATAYIPLNDFQPNCDIRRLGLTQGQHNELRK        10        20        30        40        50        60        70        80        90       100       110       120 m691.pepIRTAFKMAGDRARLKVMHSEHSRRRSVVEIISSDVFNRNEARDYVESRYLSGMDFAVDEL||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a691IRAAFKMAGDRARLKVMHSEHSRRRSVVEIISSDVFNRNEARDYVESRYLSGMDFAVDEL        70        80        90       100       110       120       130       140 m691.pep EIQHRFFHILTPQQQQMWLSSCLKX||||||||||||||||||||||||| a691 EIQHRFFHILTPQQQQMWLSSCLKX       130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2309>

g692.seq 1 GTATCGCACA CACGCTGTCG CTGTTCGGAA TCGAtacGCC GGATTTGGCG 51GAATGGCAGG GAATGGCGGA TTAAAGGACA AAAATGCCGT CTGAACACGG 101 ATGCGGTTCAGACGGCATCA TTTTATACGA CTGCCTTATT TGGCTGCGCC 151 TTCATTCCAT GCGGCAGGGTATTTGTAGCC CTCGAAGCGT TTGTGCGCGT 201 AGGCTTTGAA CGCGTCGGAG TTATAGGCCTCGGTTACGTC TTTAAGCCAT 251 TGGCTGTCTT TGTCGGCGGT TTTgacGGCA GACCAGTTGACATAGGCAAA 301 GCTCGGCTCT TGGAACAGGG CTTCGGTCAG CTTCATGCCG CTGCTTATGG351 CGTAGTTGCC GTTGACGACG GCAAAATCCA CGTCGGCGCG GCTGCGCGGC 401AGTTGTGCGG CTTCAAGCTC GACGATTTTG ATGTTTTTCA GGTTTTCCGC 451 GATGTCGGCTTTGGATGCGG TCAGCGGATT GATGCCGTCT TTGAGTTTGA 501 TCCAACCCAG TTCGTTCAGCATCACCAAGG CGCGTGCGAA GTTGGAcggG 551 TcgtTGGGCG CGGATACGGT GCTGCCGTCTTTGACTTCTT CCAGCGATTT 601 CAGTTTGCCC GGATACAGTC CCAAAGGCGC GGTCGGCACTTGGAAGGCTT 651 CGGTGATGTC CAGGTTGTGT TCTTTTTTGA AATCGTCAAG ATAGGGTTTG701 TGTTGGAAGA CGTTGATGTC CAACTCGCCC TCCGCCAATG CCAGATTCGG 751GCGCACATAG TCggTAAATT cgaccaatTT gacgGTGTag cCTTTTTTCT 801 CCAGCTCGgctTGGATTTGT TCTTTGACCA TATcgccgaa gtcgcccacg 851 gTCGTGCCGA agacgaTTTCTTTTTTCGCc GcgcCGTTAT CGGCAGAAGG 901 GGCGGCGgca gaggctgcGG GCGCGCTGTCTTTTtgaccG ccgCAGGCTG 951 CGAGGATGAG CGCGAGtgcg gcggcggaaa ggGTTTTGAAGAAGGTTTTc 1001 atATTTTCTc ctgaThis corresponds to the amino acid sequence <SEQ ID 2310; ORF 692>:

g692.pep 1 VSHTRCRCSE SIRRIWRNGR EWRIKGQKCR LNTDAVQTAS FYTTALFGCA 51FIPCGRVFVA LEAFVRVGFE RVGVIGLGYV FKPLAVFVGG FDGRPVDIGK 101 ARLLEQGFGQLHAAAYGVVA VDDGKIHVGA AARQLCGFKL DDFDVFQVFR 151 DVGFGCGQRI DAVFEFDPTQFVQHHQGACE VGRVVGRGYG AAVFDFFQRF 201 QFARIQSQRRGRHLEGFGDV QVVFFFEIVK IGFVLEDVDV QLALRQCQIR 251 AHIVGKFDQF DGVAFFLQLGLDLFFDHIAE VAHGRAEDDF FFRRAVIGRR 301 GGGRGCGRAV FLTAAGCEDE RECGGGKGFEEGFHIFS*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2311>:

m692.seq 1 GTGTTGCACA CGCTTTGTCG CTGTTCGGAA TCGATACGCC GGATTCGGCG 51GAATGGCAGG GAATGGCGGA TTAAAGGACA AAAATGCCGT CTGAACACGG 101 ATACAGTTCAGACGGCATCA TTTTATACGA CTGCCTTATT TGGCTGCGCC 151 TTCATTCCAT GCGGCAGGGGATTTGTAGCC CTCGAAGCGT TTGTGCGCGT 201 AGGCTTTGAA CGCGTCGGAG TTATAGGCCTCGGTTACGTC TTTAAGCCAT 251 TGGCTGTCTT TGTCGGCGGT TTTGACGGCA GACCAGTTGACATAGGCAAA 301 GCTCGGTTCT TGGAACAGGG CTTCGGTCAG CTTCATGCCG CTGCTTATGG351 CGTAGTTGCC GTTGACGACG GCAAAATCCA CGTCGGCGCG GCTACGCGGC 401AGTTGCGCGG CTTCAAGCTC GACGATTTTG ATGTTTTTCA GGTTCTCGGC 451 GATGTCCGCTTTGGATGCGG TCAACGGATT GATGCCGTCT TTGAGTTTGA 501 TCCAACCCAG TTCGTCGAGCATCACCAAGA CGCGGGCGAA GTTGGACGGG 551 TCGTTGGGCG CGGATACGGT GCTGCCGTCTTTGACTTCTT CCAGCGATTT 601 CAGCTTGCCC GGGTACAGTC CCAAAGGCGC GGTCGGCACTTGGAAGACTT 651 CGGTGATGTC CAGATTGTGT TCTTTTTTGA AGTCGTCAAG ATAGGGTTTG701 TGTTGGAAGA CGTTGATGTC CAACTCGCCC TCAGCCAATG CCAGATTCGG 751GCGTACATAG TCGGTAAACT CGACCAGTTT GACGGTGTAG CCTTTTTTCT 801 CCAGCTCGGCTTGGATTTGT TCTTTGACCA TATCGCCGAA GTCGCCGACG 851 GTCGTGCCGA AGACGATTTCTTTTTTCGCC GCGCCGTTGT CGGCGGCGGC 901 AGAAGCGGAT GCGGCGGGCG CGCTGTCTTTTTGACCGCCG CAGGCGGCGA 951 GGATGAGCGC GAGTGCGGCG GCGGAAAGGG TTTTGAAGAAGGTTTTCATA 1001 TTTTCTCCTG AThis corresponds to the amino acid sequence <SEQ ID 2312; ORF 692>:

m692.pep 1 VLHTLCRCSE SIRRIRRNGR EWRIKGQKCR LNTDTVQTAS FYTTALFGCA 51FIPCGRGFVA LEAFVRVGFE RVGVIGLGYV FKPLAVFVGG FDGRPVDIGK 101 ARFLEQGFGQLHAAAYGVVA VDDGKIHVGA ATRQLRGFKL DDFDVFQVLG 151 DVRFGCGQRI DAVFEFDPTQFVEHHQDAGE VGRVVGRGYG AAVFDFFQRF 201 QLARVQSQRRGRHLEDFGDV QIVFFFEVVK IGFVLEDVDV QLALSQCQIR 251 AYIVGKLDQF DGVAFFLQLGLDLFFDHIAE VADGRAEDDF FFRRAVVGGG 301 RSGCGGRAVF LTAAGGEDER ECGGGKGFEEGFHIFS*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 692 shows 91.1% identity over a 338 aa overlap with a predicted ORF(ORF 692) from N. gonorrhoeae:

m692/g692 91.1% identity in 338 aa overlap         10        20        30        40        50        60 m692.pep VLHTLCRCSESIRRIRRNGREWRIKGQKCRLNTDTVQTASFYTTALFGCAFIPCGRGFVA | || |||||||||| ||||||||||||||||||:||||||||||||||||||||| ||| g692 VSHTRCRCSESIRRIWRNGREWRIKGQKCRLNTDAVQTASFYTTALFGCAFIPCGRVFVA         10        20        30        40        50        60         70        80        90       100       110       120 m692.pep LEAFVRVGFERVGVIGLGYVFKPLAVFVGGFDGRPVDIGKARFLEQGFGQLHAAAYGVVA ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||| g692 LEAFVRVGFERVGVIGLGYVFKPLAVFVGGFDGRPVDIGKARLLEQGFGQLHAAAYGVVA         70        80        90       100       110       120        130       140       150       160       170       180 m692.pep VDDGKIHVGAATRQLRGFKLDDFDVFQVLGDVRFGCGQRIDAVFEFDPTQFVEHHQDAGE |||||||||||:||| ||||||||||||: || |||||||||||||||||||:||| | | g692 VDDGKIHVGAAARQLCGFKLDDFDVFQVFRDVGFGCGQRIDAVFEFDPTQFVQHHQGACE        130       140       150       160       170       180        190       200       210       220       230       240 m692.pep VGRVVGRGYGAAVFDFFQRFQLARVQSQRRGRHLEDFGDVQIVFFFEVVKIGFVLEDVDV |||||||||||||||||||||:||:|||||||||| |||||:|||||:|||||||||||| g692 VGRVVGRGYGAAVFDFFQRFQFARIQSQRRGRHLEGFGDVQVVFFFEIVKIGFVLEDVDV        190       200       210       220       230       240        250       260       270       280       290 m692.pep QLALSQCQIRAYIVGKLDQFDGVAFFLQLGLDLFFDHIAEVADGRAEDDFFFRRAVVG-- |||| ||||||:||||:||||||||||||||||||||||||| |||||||||||||:| g692 QLALRQCQIRAHIVGKFDQFDGVAFFLQLGLDLFFDHIAEVAHGRAEDDFFFRRAVIGRR        250       260       270       280       290       300300       310       320       330 m692.pep GGRSGCGGRAVFLTAAGGEDERECGGGKGFEEGFHIFSX || ||| ||||||||| ||||||||||||||||||||| g692 GGGRGCG-RAVFLTAAGCEDERECGGGKGFEEGFHIFSX         310       320       330The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2313>

a692.seq 1 GTGTTGCACA CGCTTTGTCG CTGTTCGGAA TCGATACGCC GGATTCGGCG 51GAATGGCAGG GAATGGCGGA TTAAAGGACA AAAATGCCGT CTGAACACGG 101 ATACGGTTCAGACGGCATCA TTTTATACGA CTGCCTTATT TGGCTGCGCC 151 TTCATTCCAT GCGGCAGGGGATTTGTAGCC CTCGAAGCGT TTGTGCGCGT 201 AGGCTTTGAA CGCGTCGGAG TTATAGGCCTCGGTTACGTC TTTAAGCCAT 251 TGGCTGTCTT TGTCGGCGGT TTTGACGGCA GACCAGTTGACATAGGCAAA 301 GCTCGGTTCT TGGAACAGGG CTTCGGTCAG CTTCATGCCG CTGCTTATGG351 CGTAGTTGCC GTTGACGACG GCAAAATCCA CGTCGGCGCG GCTACGCGGC 401AGTTGCGCGG CTTCAAGCTC GACGATTTTG ATGTTTTTCA GGTTTTCGGC 451 AATGTCCGCTTTGGATGCGG TCAGCGGATT GATGCCGTCT TTGAGTTTGA 501 TCCAACCCAG TTCGTCGAGCATCACCAAGA CGCGGGCGAA GTTGGACGGG 551 TCGTTGGGCG CGGATACGGT GCTGCCGTCTTTGACTTCTT CCAGCGATTT 601 CAGCTTGCCC GGGTACAGTC CCAAAGGCGC GGTCGGCACTTGGAAGACTT 651 CGGTGATGTC CAGATTGTGT TCTTTTTTGA AGTCGTCAAG ATAGGGTTTG701 TGTTGGAAGA CGTTGATGTC CAACTCGCCC TCAGCCAATG CCAGATTCGG 751GCGCACATAG TCGGTAAACT CGACCAGTTT GACGGTGTAG CCTTTTTTCT 801 CCAGCTCGGGTTGGATTTGT TCTTTGACCA TATCGCCGAA GTCGCCGACG 851 GTCGTGCCGA AGACGATTTCTTTTTTCGCC GCGCCGTTGT CGGCGGCGGC 901 AGAAGCGGAT GCGGCGGGCG CGCTATCTTTTTGACCGCCG CAGGCGGCGA 951 GGATGAGCGC GAGTGCGGCG GCGGAAAGGG TTTTGAAGAAGGTTTTCATA 1001 TTTTCTCCTG AThis corresponds to the amino acid sequence <SEQ ID 2314; ORF 692.a>:

a692.pep 1 VLHTLCRCSE SIRRIRRNGR EWRIKGQKCR LNTDTVQTAS FYTTALFGCA 51FIPCGRGFVA LEAFVRVGFE RVGVIGLGYV FKPLAVFVGG FDGRPVDIGK 101 ARFLEQGFGQLHAAAYGVVA VDDGKIHVGA ATRQLRGFKL DDFDVFQVFG 151 NVRFGCGQRI DAVFEFDPTQFVEHHQDAGE VGRVVGRGYG AAVFDFFQRF 201 QLARVQSQRRGRHLEDFGDV QIVFFFEVVK IGFVLEDVDV QLALSQCQIR 251 AHIVGKLDQF DGVAFFLQLGLDLFFDHIAE VADGRAEDDF FFRRAVVGGG 301 RSGCGGRAIF LTAAGGEDER ECGGGKGFEEGFHIFS*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 692 shows 98.8% identity over a 336 aa overlap with a predicted ORF(ORF 692) from N. meningitidis:

m692/a692 98.8% identity in 336 aa overlap        10        20        30        40        50        60 m692.pepVLHTLCRCSESIRRIRRNGREWRIKGQKCRLNTDTVQTASFYTTALFGCAFIPCGRGFVA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a692VLHTLCRCSESIRRIRRNGREWRIKGQKCRLNTDTVQTASFYTTALFGCAFIPCGRGFVA        10        20        30        40        50        60        70        80        90       100       110       120 m692.pepLEAFVRVGFERVGVIGLGYVFKPLAVFVGGFDGRPVDIGKARFLEQGFGQLHAAAYGVVA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a692LEAFVRVGFERVGVIGLGYVFKPLAVFVGGFDGRPVDIGKARFLEQGFGQLHAAAYGVVA        70        80        90       100       110       120       130       140       150       160       170       180 m692.pepVDDGKIHVGAATRQLRGFKLDDFDVFQVLGDVRFGCGQRIDAVFEFDPTQFVEHHQDAGE||||||||||||||||||||||||||||:|:||||||||||||||||||||||||||||| a692VDDGKIHVGAATRQLRGFKLDDFDVFQVFGNVRFGCGQRIDAVFEFDPTQFVEHHQDAGE       130       140       150       160       170       180       190       200       210       220       230       240 m692.pepVGRVVGRGYGAAVFDFFQRFQLARVQSQRRGRHLEDFGDVQIVFFFEVVKIGFVLEDVDV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a692VGRVVGRGYGAAVFDFFQRFQLARVQSQRRGRHLEDFGDVQIVFFFEVVKIGFVLEDVDV       190       200       210       220       230       240       250       260       270       280       290       300 m692.pepQLALSQCQIRAYIVGKLDQFDGVAFFLQLGLDLFFDHIAEVADGRAEDDFFFRRAVVGGG|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||| a692QLALSQCQIRAHIVGKLDQFDGVAFFLQLGLDLFFDHIAEVADGRAEDDFFFRRAVVGGG       250       260       270       280       290       300       310       32010       330 m692.pepRSGCGGRAVFLTAAGGEDERECGGGKGFEEGFHIFSX||||||||:|||||||||||||||||||||||||||| a692RSGCGGRAIFLTAAGGEDERECGGGKGFEEGFHIFSX        310       320       330The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2315>:

g694.seq 1 TCGGCATTTG TGTTGCCCAA ACATCCGATG CCTGCGTTAA CGCCTGCGTC 51AACGTTTGCA CAAATCGGGT TTGGTTTCGC CCTCGCGGCG CAGCTCCTTG 101 GGCAGGACGAACACGATGCT TTCTTCCGCG CCCCCCCCTT CGCGCACGGT 151 TTCATGCCCC CATCCGCGTATGGTTGCCAA TACTTCCCGC ACCAACACTT 201 CGGGCGCGGA CGCGCCTGCC GTTACGCCGACTTTGCTTTT GCCTTCAAAC 251 CACGTGCGTT GCaggTAGGA CGCGTTGTCC ACCATATACGCATCGATTCC 301 GCGCGATGCC GCCACTTCGC GCAGGCGGTT GCTGTTGGAC GAATTGGGCG351 AACCGACCAC AATCACGATG TCGCACTGTT CCGCCAGCTC TTTGACGGCG 401GTTTGCCGGT TGGTCGTCGC ATAGCAGATG TCTTCCTTGT GCGGATTGCG 451 GATATTGGGGAAACGCGCGT TCAGCGCGGC GATGATGTCT TTGGTTTCAT 501 CGACCGAGAG CGTGGTTTGGCTGACATAGG CGAGTTTGTC GGGGTTTCTG 551 ACTTCGAGTT TTGCCACATC TCCGACCGTTTCGACCAAAA GCATTTTGCC 601 CGGTGCAAGC TGCCCCATCG TGCCTTCGAC CTCGGCGTGCCCCTTATGCC 651 CGATCATGAT GATTTCACAG TCTTGGGCAT CCAGTCGGGC GACTTCCTTA701 TGCACTTTCG TCACCAGCGG GCAAGTCGCA TCAAATACCC GGAAACCGCG 751CTCCGCCGCT TCCTGCTGCA CCGCCTTCGA TACGCCGTGT GCCGAATAAA 801 CCAGTGTCGCGCCCGGCGGC ACTTCCGCCA AGTCTTCGAT AAACACCGCG 851 CCTTTTTCGC GCAGGTTGTCCACGACGAAT TTGTTGTGGA CGACTTCGTG 901 GCGCACATAA ACCGGCGCGC CGAATTCTTCCAAAGCACGT TCGACAATAC 951 TGATTGCCCG ATCCACACCG GCGCAGAAGC CGCGCGGATTGGCAAGGATG 1001 ATGGTTTTTC CGTTCATAAG TTTTGCATTC CGTGTTCAGA CGGCATTCAC1051 GTTTTTTTGC TNNATCTTTG CGATGGACGA TATTGTCAAG CACCGCCAAC 1101ACCGCACCGA CGCAGATAAThis corresponds to the amino acid sequence <SEQ ID 2316; ORF 694>:

g694.pep (partial) 1 SAFVLPKHPM PALTPASTFA QIGFGFALAA QLLGQDEHDAFFRAPPFAHG 51 FMPPSAYGCQ YFPHQHFGRG RACRYADFAF AFKPRALQVG RVVHHIRIDS 101ARCRHFAQAV AVGRIGRTDH NHDVALFRQL FDGGLPVGRR IADVFLVRIA 151 DIGETRVQRGDDVFGFIDRE RGLADIGEFV GVSDFEFCHI SDRFDQKHFA 201 RCKLPHRAFD LGVPLMPDHDDFTVLGIQSG DFLMHFRHQR ASRIKYPETA 251 LRRFLLHRLR YAVCRINQCR ARRHFRQVFDKHRAFFAQVV HDEFVVDDFV 301 AHINRRAEFF QSTFDNTDCP IHTGAEAARI GKDDGFSVHKFCIPCSDGIH 351 VFLLXLCDGR YCQAPPTPHR RR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2317>:

m694.seq 1 TTGGTTTCCG CATCCGGCAC ACGGCAAAAA TGCCGTCTGA AGCCTGTTCA 51GACGGCATTT GTGTTGCCCA AACATTCAAC GCCTGCGTCA ACGTTTGCAC 101 AAATCGGGTTTGGTTTCGCC CTCGCGGCGC AACTCTTTGG GCAGGACGAA 151 CACAATGCTT TCTTCCGCACCCTCGCCTTC GCGTACGGTT TCGTGCCCCC 201 ATCCGCGTAT GGTTGCCAGT ACTTCCCGCACCAACACTTC GGGCGCGGAC 251 GCGCCTGCCG TTACGCCGAC TTTGTTTTTG CCCTCAAACCATGCGCGTTG 301 CAGGTAGCCT GCATTATCCA CCATATACGC ATCGATTCCG CGCGATGCCG351 CCACTTCGCG CAAGCGGTTG CTGTTGGACG AATTGGGCGA ACCGACCACA 401ATCACGATGT CGCACTGTTC TGCCAACTCT TTGACGGCGG TTTGCCGGTT 451 GGTCGTCGCATAGCAGATAT CTTCCTTGTG CGGATTGCGG ATATTGGGGA 501 AACGCGCGTT CAGCGCGGCGATGATGTCTT TGGTTTCATC GACCGAGAGC 551 GTGGTTTGGC TGACATAGGC GAGTTTGTCGGGGTTTCTGA CTTCGAGTTT 601 TGCCACATCT CCGACCGTTT CGACCAAAAG CATTTTGCCCGGCGCAAGCT 651 GCCCCATCGT TCCTTCGACC TCGACGTGCC CCTTATGCCC GATCATGATG701 ATTTCACAGT CTTGGGCATC CAGTCGGGCG ACTTCCTTAT GCACTTTCGT 751CACCAGCGGG CAAGTCGCAT CAAACACGCG GAAACCGCgC TCCGCCGCTT 801 CTTGCCGCACCGCCTTCGAT ACGCCGTGTG CCGAATAAAC CAGTGTCGCG 851 CCCGGCGGCA CTTCCGCCAAGTCTTCAATA AACACCGCAC CTTTTTCACG 901 CAGGTTGTCC ACGACGAATT TGTTGTGAACGACTTCGTGG CGCACATAAA 951 TCGGCGCGCC GAACTCTTCC AAAGCACGTT CGACAATACTGATT GCCCGA 1001 TCCACACCAG CGCAGAAGCC GCGCGGATTG GCAAGGATGA TGGTTTTCTC1051 GTTCATAAGC CCGGTATTTC GTTTTCAGAC GGCATCAATA TTTTTCTTCT 1101TGGGTTTTAC GGTGGACGAT GTTGTCCAAC ACCGCCAACA CCGCACCGAC 1151 GCAGATAAThis corresponds to the amino acid sequence <SEQ ID 2318; ORF 694>:

m694.pep 1 LVSASGTRQK CRLKPVQTAF VLPKHSTPAS TFAQIGFGFA LAAQLFGQDE 51HNAFFRTLAF AYGFVPPSAY GCQYFPHQHF GRGRACRYAD FVFALKPCAL 101 QVACIIHHIRIDSARCRHFA QAVAVGRIGR TDHNHDVALF CQLFDGGLPV 151 GRRIADIFLV RIADIGETRVQRGDDVFGFI DRERGLADIG EFVGVSDFEF 201 CHISDRFDQK HFARRKLPHR SFDLDVPLMPDHDDFTVLGI QSGDFLMHFR 251 HQRASRIKHA ETALRRFLPH RLRYAVCRIN QCRARRHFRQVFNKHRTFFT 301 QVVHDEFVVN DFVAHINRRA ELFQSTFDNT DCPIHTSAEA ARIGKDDGFL351 VHKPGISFSD GINIFLLGFY GGRCCPTPPT PHRRR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 694 shows 86.8% identity over a 372 aa overlap with a predicted ORF(ORF 694) from N. gonorrhoeae:

m694/g694 86.8% identity in 372 aa overlap        10        20            30        40        50 m694.pepLVSASGTRQKCRLKPVQTAFVLPKHS----TPASTFAQIGFGFALAAQLFGQDEHNAFFR                 :|||||||     |||||||||||||||||||:|||||:|||| g694                 SAFVLPKHPMPALTPASTFAQIGFGFALAAQLLGQDEHDAFFR                         10        20        30        40  60        70        80        90       100       110 m694.pepTLAFAYGFVPPSAYGCQYFPHQHFGRGRACRYADFVFALKPCALQVACIIHHIRIDSARC:  ||:||:||||||||||||||||||||||||||:||:|| ||||: ::|||||||||| g694APPFAHGFMPPSAYGCQYFPHQHFGRGRACRYADFAFAFKPRALQVGRVVHHIRIDSARC     50        60        70        80        90       100 120       130       140       150       160       170 m694.pepRHFAQAVAVGRIGRTDHNHDVALFCQLFDGGLPVGRRIADIFLVRIADIGETRVQRGDDV|||||||||||||||||||||||| |||||||||||||||:||||||||||||||||||| g694RHFAQAVAVGRIGRTDHNHDVALFRQLFDGGLPVGRRIADVFLVRIADIGETRVQRGDDV    110       120       130       140       150       160 180       190       200       210       220       230 m694.pepFGFIDRERGLADIGEFVGVSDFEFCHISDRFDQKHFARRKLPHRSFDLDVPLMPDHDDFT|||||||||||||||||||||||||||||||||||||| |||||:||| ||||||||||| g694FGFIDRERGLADIGEFVGVSDFEFCHISDRFDQKHFARCKLPHRAFDLGVPLMPDHDDFT    170       180       190       200       210       220 240       250       260       270       280       290 m694.pepVLGIQSGDFLMHFRHQRASRIKHAETALRRFLPHRLRYAVCRINQCRARRHFRQVFNKHR||||||||||||||||||||||: |||||||| |||||||||||||||||||||||:||| g694VLGIQSGDFLMHFRHQRASRIKYPETALRRFLLHRLRYAVCRINQCRARRHFRQVFDKHR    230       240       250       260       270       280 300       310       320       330       340       350 m694.pepTFFTQVVHDEFVVNDFVAHINRRAELFQSTFDNTDCPIHTSAEAARIGKDDGFLVHKPGI:||:|||||||||:|||||||||||:||||||||||||||:||||||||||| |||  | g694AFFAQVVHDEFVVDDFVAHINRRAEFFQSTFDNTDCPIHTGAEAARIGKDDGFSVHKFCI    290       300       310       320       330       340 360       370       380 m694.pep SFSDGINIFLLGFYGGRCCPTPPTPHRRRX  ||||::||  :  || | :||||||||| g694 PCSDGIHVFLXXLCDGRYCQAPPTPHRRRX    350       360       370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2319>:

a694.seq 1 TTGGTTTCCG CATCCGGCAC ACGGCAAAAA TGCCGTCTGA AGCCTGTTCA 51GACGGCATTT GTGTTGCCCA AACATTCAAC GCCTGCGTCA ACGTTTGCAC 101 AAATCGGGTTTGGTTTCGCC CTCGCGGCGC AACTCTTTGG GCAGGACGAA 151 CACAATGCTT TCTTCCGCACCCTCGCCTTC GCGTACGGTT TCGTGCCCCC 201 ATCCGCGTAT GGTTGCCAGT ACTTCCCGCACCAACACTTC GGGCGCGGAC 251 GCGCCTGCCG TTACGCCGAC TTTGTTTTTG CCCTCAAACCATGCGCGTTG 301 CAGGTAGCCT GCATTATCCA CCATATACGC ATCGATTCCG CGCGATGCCG351 CCACTTCGCG CAAGCGGTTG CTGTTGGACG AATTGGGCGA ACCGACCACA 401ATCACGATGT CGCACTGTTC TGCCAACTCT TTGACGGCGG TTTGCCGGTT 451 GGTCGTCGCATAGCAGATAT CTTCCTTGTG CGGATTGCGG ATATTGGGGA 501 AACGCGCGTT CAGCGCGGCGATGATGTCTT TGGTTTCATC GACCGAGAGC 551 GTGGTTTGGC TGACATAGGC GAGTTTGTCGGGGTTTCTGA CTTCGAGTTT 601 TGCCACATCT CCGACCGTTT CGACCAAAAG CATTTTGCCCGGCGCAAGCT 651 GCCCCATCGT TCCTTCGACC TCGACGTGCC CCTTATGCCC GATCATGATG701 ATTTCACAGT CTTGGGCATC CAGTCGGGCG ACTTCCTTAT GCACTTTCGT 751CACCAGCGGG CAAGTCGCAT CAAACACGCG GAAACCGCGC TCCGCCGCTT 801 CTTGCCGCACCGCCTTCGAT ACGCCGTGTG CCGAATAAAC CAGTGTCGCG 851 CCCGGCGGCA CTTCCGCCAAGTCTTCAATA AACACCGCAC CTTTTTCACG 901 CAGGTTGTCC ACGACGAATT TGTTGTGAACGACTTCGTGG CGCACATAAA 951 TCGGCGCGCC GAACTCTTCC AAAGCACGTT CGACAATACTGATTGCCCGA 1001 TCCACACCAG CGCAGAAGCC GCGCGGATTG GCAAGGATGA TGGTTTTCTC1051 GTTCATAAGC CCGGTATTTC GTTTTCAGAC GGCATCAATA TTTTTCTTCT 1101TGGGTTTTAC GGTGGACGAT GTTGTCCAAC ACCGCCAACA CCGCACCGAC 1151 GCAGATAAThis corresponds to the amino acid sequence <SEQ ID 2320; ORF 694.a>:

a694.pep 1 LVSASGTRQK CRLKPVQTAF VLPKHSTPAS TFAQIGFGFA LAAQLFGQDE 51HNAFFRTLAF AYGFVPPSAY GCQYFPHQHF GRGRACRYAD FVFALKPCAL 101 QVACIIHHIRIDSARCRHFA QAVAVGRIGR TDHNHDVALF CQLFDGGLPV 151 GRRIADIFLV RIADIGETRVQRGDDVFGFI DRERGLADIG EFVGVSDFEF 201 CHISDRFDQK HFARRKLPHR SFDLDVPLMPDHDDFTVLGI QSGDFLMHFR 251 HQRASRIKHA ETALRRFLPH RLRYAVCRIN QCRARRHFRQVFNKHRTFFT 301 QVVHDEFVVN DFVAHINRRA ELFQSTFDNT DCPIHTSAEA ARIGKDDGFL351 VHKPGISFSD GINIFLLGFY GGRCCPTPPT PHRRR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 694 shows 100% identity over a 385 aa overlap with a predicted ORF(ORF 694) from N. meningitidis:

m694/a694 100.0% identity in 385 aa overlap        10        20        30        40        50        60 m694.pepLVSASGTRQKCRLKPVQTAFVLPKHSTPASTFAQIGFGFALAAQLFGQDEHNAFFRTLAF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a694LVSASGTRQKCRLKPVQTAFVLPKHSTPASTFAQIGFGFALAAQLFGQDEHNAFFRTLAF        10        20        30        40        50        60        70        80        90       100       110       120 m694.pepAYGFVPPSAYGCQYFPHQHFGRGRACRYADFVFALKPCALQVACIIHHIRIDSARCRHFA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a694AYGFVPPSAYGCQYFPHQHFGRGRACRYADFVFALKPCALQVACIIHHIRIDSARCRHFA        70        80        90       100       110       120       130       140       150       160       170       180 m694.pepQAVAVGRIGRTDHNHDVALFCQLFDGGLPVGRRIADIFLVRIADIGETRVQRGDDVFGFI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a694QAVAVGRIGRTDHNHDVALFCQLFDGGLPVGRRIADIFLVRIADIGETRVQRGDDVFGFI       130       140       150       160       170       180       190       200       210       220       230       240 m694.pepDRERGLADIGEFVGVSDFEFCHISDRFDQKHFARRKLPHRSFDLDVPLMPDHDDFTVLGI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a694DRERGLADIGEFVGVSDFEFCHISDRFDQKHFARRKLPHRSFDLDVPLMPDHDDFTVLGI       190       200       210       220       230       240       250       260       270       280       290       300 m694.pepQSGDFLMHFRHQRASRIKHAETALRRFLPHRLRYAVCRINQCRARRHFRQVFNKHRTFFT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a694QSGDFLMHFRHQRASRIKHAETALRRFLPHRLRYAVCRINQCRARRHFRQVFNKHRTFFT       250       260       270       280       290       300       310       320       330       340       350       360 m694.pepVHDEFVVNDFVAHINRRAELFQSTFDNTDCPIHTSAEAARIGKDDGFLVHKPGISFSD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a694QVVHDEFVVNDFVAHINRRAELFQSTFDNTDCPIHTSAEAARIGKDDGFLVHKPGISFSD       310       320       330       340       350       360       370       380 m694.pep GINIFLLGFYGGRCCPTPPTPHRRRX|||||||||||||||||||||||||| a694 GINIFLLGFYGGRCCPTPPTPHRRRX       370       380The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2321>:

g695.seq 1 TTGCCTCAAA CTCGTCCGGC AAGGCGGCAT CATCGCCATC GACAATATTT 51TGTTGAACGG AAGGGTGATG CGCGAAGCGG CTTTTGATGC GCCGCCCAGT 101 GTCAAAATTCTCAAAGATTT CAATCAAAAC CTGCCGAACG ATACGCGGAT 151 TGTCCCCATC ACCCTGCCCGTCGGCGACGG TTTGACCCTG CTTCTGAAAA 201 AATAATGAAG ACCAAATTAC CGCTTTTTATCATTTGGCTG TCTGTGTCTG 251 CCTCCTGTGC TTCCGTTTTA CCCGTTCCGG AGGGCAGCCGAACCGAAATG 301 CCGACACAGG AAAATGCTTC AGACGGCATT CCCTATCCCG TTCCCACTCT351 GCAAGACCGT TTGGACTATC TGGAAGGCAA AATCGTCCGG CTGTCGAACG 401AAGTGGAAAT GTTAAACGGG AAAGTCAAAG CATTGGAGCA TACGAAAATA 451 CACCCTTCCGGCAGGACATA CGTCCAAAAA CTCGACGACC GCAAATTGAA 501 AGAGCATTAC CTCAATACCGAAGGCGGCAG CGCATCCGCA CATACCGTCG 551 AAACCGCACA AAACCTCTAC AATCAGGCACTCAAACACTA TCAAAACGGC 601 AGGTTTTCTG CCGCAGCCGC CTTGTTGAAG GGGGCGGACGGCGGAGACGG 651 CGGCAGCATC GCGCAACGCA GTATGTACCT GTTGCTGCAA AGCAGGGCGC701 GTATGGGGAA CTGTGAATCT GTCATCGAAA TCGGAGGGCG TTACGCCAAC 751CGTTTCAAAG ACAGCCCAAC CGCGCCCGAA GTCATATTCA AAATCGGCGA 801 ATGCCAATACAGGCTTCAGC AAAAAGACAT TGCAAGGGCG ACTTGGCGCA 851 GCCTGATACA GACCTATCCCGGCAGCCCGG CGGCAAAACG CGCCGCCGCA 901 GCCGTACGCA AACGATAGThis corresponds to the amino acid sequence <SEQ ID 2322; ORF 695>:

g695.pep 1 LPQTRPARRH HRHRQYFVER KGDARSGF*C AAQCQNSQRF QSKPAERYAD 51CPHHPARRRR FDPASEKIMK TKLPLFIIWL SVSASCASVL PVPEGSRTEM 101 PTQENASDGIPYPVPTLQDR LDYLEGKIVR LSNEVEMLNG KVKALEHTKI 151 HPSGRTYVQK LDDRKLKEHYLNTEGGSASA HTVETAQNLY NQALKHYQNG 201 RFSAAAALLK GADGGDGGSI AQRSMYLLLQSRARMGNCES VIEIGGRYAN 251 RFKDSPTAPE VIFKIGECQY RLQQKDIARA TWRSLIQTYPGSPAAKRAAA 301 AVRKR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2323>:

m695.seq 1 TTGCCTCAAA CTCGTCCGTC AAGGCGGCAT CATCGCCATC GACAATATTT 51TGCTGAACGG AAGGGTGATG CGCGAAGCGG CTTCCGATGC GCCGCCCAGC 101 GTCGGCATCCTCAAAGATTT CAATCAAAAC CTGCCGAACG ACCCGCGCAT 151 CGTCCCCATC ACCCTGCCCGTCGGCGACGG CTTGACCCTG CTTCTGAAAA 201 AATAATGAAG ATCAAATTAC CGCTTTTTATCATTTGGCTG TCTGTGTCCG 251 CCTCCTGTGC TTCCGTTTCA CCCGTTCCGG CAGGCAGCCAAACCGAAATG 301 TCGACACGGG AAAATGCTTC AGACGGCATT CCCTATCCCG TTCCGACCTT351 GCAAGACCGT TTGGACTATC TGGAAGGCAA AATCGTCCGG CTGTCGAACG 401AAGTGGAAAC CTTAAACGGC AAAGTCAAAG CACTGGAACA CGCAAAAACA 451 CATTCTTCCGGCAGGGCATA CGTCCAAAAA CTCGACGACC GCAAGTTGAA 501 AGAGCATTAC CTCAATACCGAAGGCGGCAG CGCATCCGCA CATACTGTCG 551 AAACCGCACA AAACCTCTAC AATCAGGCACTCAAACACTA TAAAAGCGGC 601 AAGTTTTCTG CCGCTGCCTC CCTGTTGAAA GGCGCGGACGGAGGCGACGG 651 CGGCAGCATC GCGCAACGCA GTATGTACCT GTTGCTGCAA AGCAGGGCGC701 GTATGGGCAA CTGCGAATCC GTCATCGAAA TCGGAGGGCG TTACGCCAAC 751CGTTTCAAAG ACAGCCCAAC CGCGCCTGAA GCCATGTTCA AAATCGGCGA 801 ATGCCAATACAGGCTTCAGC AAAAAGACAT TGCAAGGGCG ACTTGGCGCA 851 GCCTGATACA GACCTATCCCGGCAGCCCGG CGGCAAAACG CGCCGCCGCA 901 GCCGTGCGCA AACGATAGThis corresponds to the amino acid sequence <SEQ ID 2324; ORF 695>:

m695.pep 1 LPQTRPSRRH HRHRQYFAER KGDARSGFRC AAQRRHPQRF QSKPAERPAH 51RPHHPARRRR LDPASEKIMK IKLPLFIIWL SVSASCASVS PVPAGSQTEM 101 STRENASDGIPYPVPTLQDR LDYLEGKIVR LSNEVETLNG KVKALEHAKT 151 HSSGRAYVQK LDDRKLKEHYLNTEGGSASA HTVETAQNLY NQALKHYKSG 201 KFSAAASLLK GADGGDGGSI AQRSMYLLLQSRARMGNCES VIEIGGRYAN 251 RFKDSPTAPE AMFKIGECQY RLQQKDIARA TWRSLIQTYPGSPAAKRAAA 301 AVRKR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 694 shows 90.8% identity over a 305 aa overlap with a predicted ORF(ORF 695) from N. gonorrhoeae:

m695/g695 90.8% identity in 305 aa overlap        10        20        30        40        50        60 m695.pepLPQTRPSRRHHRHRQYFAERKGDARSGERCAAQRRHPQRFQSKPAERPAHRPHHPARRRR||||||:||||||||||:|||||||||| |||| :: |||||||||| |  ||||||||| g695LPQTRPARRHHRHRQYFVERKGDARSGFXCAAQCQNSQRFQSKPAERYADCPHHPARRRR        10        20        30        40        50        60        70        80        90       100       110       120 m695.pepLDPASEKIMKIKLPLFIIWLSVSASCASVSPVPAGSQTEMSTRENASDGIPYPVPTLQDR:||||||||| |||||||||||||||||| ||| ||:||| |:||||||||||||||||| g695FDPASEKIMKTKLPLFIIWLSVSASCASVLPVPEGSRTEMPTQENASDGIPYPVPTLQDR        70        80        90       100       110       120       130       140       150       160       170       180 m695.pepLDYLEGKIVRLSNEVELLNGKVKALEHAKTHSSGRAYVQKLDDRKLKEHYLNTEGGSASA|||||||||||||||| ||||||||||:| | |||:|||||||||||||||||||||||| g695LDYLEGKIVRLSNEVEMLNGKVKALEHTKIHPSGRTYVQKLDDRKLKEHYLNTEGGSASA       130       140       150       160       170       180       190       200       210       220       230       240 m695.pepHTVETAQNLYNQALKHYKSGKFSAAASLLKGADGGDGGSIAQRSMYLLLQSRARMGNCES|||||||||||||||||::|:|||||:||||||||||||||||||||||||||||||||| g695HTVETAQNLYNQALKHYQNGRFSAAAALLKGADGGDGGSIAQRSMYLLLQSRARMGNCES       190       200       210       220       230       240       250       260       270       280       290       300 m695.pepVIEIGGRYANRFKDSPTAPEAMFKIGECQYRLQQKDIARATWRSLIQTYPGSPAAKRAAA||||||||||||||||||||::|||||||||||||||||||||||||||||||||||||| g695VIEIGGRYANRFKDSPTAPEVIFKIGECQYRLQQKDIARATWRSLIQTYPGSPAAKRAAA       250       260       270       280       290       300 m695.pepAVRKRX |||||| g695 AVRKRXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2325>:

a695.seq 1 TTGCCTCAAG CTTGTCCGGC AAGGCGGCAT CATTGCCATC GACAATATTT 51TGTTGAACGG AAGGGTGATG CGCGAAGCGG CTTCCGATGC GCCGCCCAGC 101 GTCGGCATCCTCAAAGATTT TAATCAAAAC CTGCCGAACG ATACGCGGAT 151 TGTCCCCATC ACCCTGCCCGTCGGCGACGG TTTGACCCTG CTTCTGAAAA 201 AATAATGAAG ACCAAATTAC CGCTTTTTATCATTTGGCTG TCCGTATCCG 251 CCGCCTGTTC TTCCCCTGTT TCCCGCAATA TTCAGGATATGCGGCTCGAA 301 CCGCAGGCAG AGGCAGGTAG TTCGGACGCT ATTCCCTATC CCGTTCCCAC351 TCTGCAAGAC CGTTTGGATT ATCTGGAAGG CACACTCGTC CGCCTGTCGA 401ACGAAGTGGA AACCTTAAAC GGCAAAGTCA AAGCACTGGA GCATGCGAAA 451 ACACACCCTTCCAGCAGGGC ATACGTCCAA AAACTCGACG ACCGCAAGTT 501 GAAAGAGCAT TACCTCAATACCGAAGGCGG CAGCGCATCC GCACATACCG 551 TCGAAACCGC ACAAAACCTC TACAATCAGGCACTCAAACA CTATAAAAGC 601 GGCAGGTTTT CTGCCGCTGC CTCCCTGTTG AAAGGCGCGGACGGAGGCGA 651 CGGCGGCAGC ATCGCGCAAC GCAGTATGTA CCTGTTGCTG CAAAGCAGGG701 CGCGTATGGG CAACTGCGAA TCCGTCATCG AAATCGGAGG GCGTTACGCC 751AACCGTTTCA AAGACAGCCC AACCGCGCCT GAAGCCATGT TCAAAATCGG 801 CGAATGCCAATACAGGCTTC AGCAAAAAGA CATTGCAAGG GCGACTTGGC 851 GCAGCCTGAT ACAGACCTATCCCGGCAGCC CGGCGGCAAA ACGCGCCGCC 901 GCAGCCGTGC GCAAACGATA GThis corresponds to the amino acid sequence <SEQ ID 2326; ORF 695.a>:

a695.pep 1 LPQACPARRH HCHRQYFVER KGDARSGFRC AAQRRHPQRF *SKPAERYAD 51CPHHPARRRR FDPASEKIMK TKLPLFIIWL SVSAACSSPV SRNIQDMRLE 101 PQAEAGSSDAIPYPVPTLQD RLDYLEGTLV RLSNEVETLN GKVKALEHAK 151 THPSSRAYVQ KLDDRKLKEHYLNTEGGSAS AHTVETAQNL YNQALKHYKS 201 GRFSAAASLL KGADGGDGGS IAQRSMYLLLQSRARMGNCE SVIEIGGRYA 251 NRFKDSPTAP EAMFKIGECQ YRLQQKDIAR ATWRSLIQTYPGSPAAKRAA 301 AAVRKR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 695 shows 88.3% identity over a 308 aa overlap with a predicted ORF(ORF 695) from N. meningitidis:

m695/a695 88.3% identity in 308 aa overlap         10        20        30        40        50        60 m695.pep LPQTRPSRRHHRHRQYFAERKGDARSGFRCAAQRRHPQRFQSKPAERPAHRPHHPARRRR  |||:|:|||| |||||:|||||||||||||||||||||| |||||| |  ||||||||| a695 LPQACPARRHHCHRQYFVERKGDARSGFRCAAQRRHPQRFXSKPAERYADCPHHPARRRR         10        20        30        40        50        60         70        80        90          100       110 m695.pep LDPASEKIMKIKLPLFIIWLSVSASCASVSPVPAGSQT---EMSTRENASDGIPYPVPTL :||||||||| |||||||||||||:|:|  ||  : |    | ::: ::||:|||||||| a695 FDPASEKIMKTKLPLFIIWLSVSAACSS--PVSRNIQDMRLEPQAEAGSSDAIPYPVPTL         70        80          90       100       110 120       130       140       150       160       170 m695.pep QDRLDYLEGKIVRLSNEVELLNGKVKALEHAKTHSSGRAYVQKLDDRKLKEHYLNTEGGS ||||||||| :||||||||||||||||||||||| |:||||||||||||||||||||||| a695QDRLDYLEGTLVRLSNEVETLNGKVKALEHAKTHPSSRAYVQKLDDRKLKEHYLNTEGGS120      130       140       150       160       170 180       190       200       210       220       230 m695.pep ASAHTVETAQNLYNQALKHYKSGKFSAAASLLKGADGGDGGSIAQRSMYLLLQSRARMGN |||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| a695 ASAHTVETAQNLYNQALKHYKSGRFSAAASLLKGADGGDGGSIAQRSMYLLLQSRARMGN180      190       200       210       220       230 240       250       260       270       280       290 m695.pep CESVIEIGGRYANRFKDSPLAPEAMFKIGECQYRLQQKDIARATWRSLIQTYPGSPAAKR |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a695 CESVIEIGGRYANRFKDSPLAPEAMFKIGECQYRLQQKDIARATWRSLIQTYPGSPAAKR240      250       260       270       280       290  300 m695.pep AAAAVRKRX  ||||||||| a695  AAAAVRKRX 300The following partial DNA sequence was identified in N. gonorrhoeaeg696.seq: not foundThis corresponds to the amino acid sequence <ORF 696.ng>:g696.pep: not foundThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2327>:

m696.seq 1 TTGGGTTGCC GGCAGGCGGC ATCCCATCAT TTTTGCCAAG GCAACAAATT 51ATTTGGCGGC ATCTTTCATT TTGTCTGCCG CTTCCTGAGT CGCGTCGGCA 101 GCTTTGTTCAAAGTATCTTT AGCTGCTTCA GTTACAGCTT CTTTGGCTTC 151 AGTTACAGCT TCCTCGGCACTTGCCTTTGC ATCAGCCGCA GCATCTTTGA 201 CTTGGTCTTT CGCTTCTTCG ACGGCAGAAGCGGCAGACTC GGCGGCAGAA 251 GCCGCAGTGT CTTTAACATC GGACTCAACG GCTTGAACCGCTTCCTTAAC 301 CTCCTGTTTG GCTTCTTGCG AACAAGCTGC CAAGGCAGCC GCCATCATTG351 CGGCAATCAA TAAThis corresponds to the amino acid sequence <SEQ ID 2328; ORF 696>:

m696.pep 1 LGCRQAASHH FCQGNKLFGG IFHFVCRFLS RVGSFVQSIF SCFSYSFFGF 51SYSFLGTCLC ISRSIFDLVF RFFDGRSGRL GGRSRSVFNI GLNGLNRFLN 101 LLFGFLRTSCQGSRHHCGNQ *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2329>:

a696.seq 1 TTGGGTTGCC GGCAGGCGGC ATCCCATCAT TTTTGCCAAG GCAACAAATT 51ATTTGGCGGC ATCTTTCATT TTGTCTGCCG CTTCCTGAGT CGCGTCGGCA 101 GCTTTGTTCAAAGTATCTTT AGCTGCTTCA GTTACAGCTT CTTTGGCTTC 151 AGTTACAGCT TCCTCGGCACTTGCCTTTGC ATCAGCCGCA GCATCTTTGA 201 CTTGGTCTTT CGCTTCTTCG ACGGCAGAAGCGGCAGACTC GGCGGCAGAA 251 GCCGCAGTGT CTTTAACATC GGACTCAACG GCTTGAACCGCTTCCTTAAC 301 CTCCTGTTTG GCTTCTTGCG AACAAGCTGC CAAGGCAGCC GCCATCATTG351 CGGCAATCAA TAAThis corresponds to the amino acid sequence <SEQ ID 2330. ORF 696.a>:

a696.pep 1 LGCRQAASHH FCQGNKLFGG IFHFVCRFLS RVGSFVQSIF SCFSYSFFGF 51SYSFLGTCLC ISRSIFDLVF RFFDGRSGRL GGRSRSVFNI GLNGLNRFLN 101 LLFGFLRTSCQGSRHHCGNQ *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N meningitidisORF 696 shows 100.0% identity over a 120 aa overlap with a predicted ORF(ORF 696) from N. meningitidis:

m696/a696 100.0% identity in 120 aa overlap        10        20        30        40        50        60 m696.pepLGCRQAASHHFCQGNKLFGGIFHFVCRFLSRVGSFVQSIFSCFSYSFFGFSYSFLGTCLC|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a696LGCRQAASHHFCQGNKLFGGIFHFVCRFLSRVGSFVQSIFSCFSYSFFGFSYSFLGTCLC        10        20        30        40        50        60        70        80        90       100       110       120 m696.pepISRSIFDLVFRFFDGRSGRLGGRSRSVFNIGLNGLNRFLNLLFGFLRTSCQGSRHHCGNQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a696ISRSIFDLVFRFFDGRSGRLGGRSRSVFNIGLNGLNRFLNLLFGFLRTSCQGSRHHCGNQ        70        80        90       100       110       120 m696.pep X| a696 XThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2331>:

g700.seq 1 ATGAGCAGCC TGATGACGTT GTTTTCGGTA TTGGTACCGA TGTTTGCCGG 51ATTTTTTATC CGTGTTCCCA AGCCTTACCT GCCCGCTTCG GACAAGGTGC 101 TGTCGGTTTTGGTGTATGCC GTGCTGCTGC TGATCGGCGT ATCGTTGTCG 151 CGCGTGGAGG ATTTGGGTTCGCGGTTGGGC GATATGGCGT TGACGGTTCT 201 GTGGCTGTTT GTTTGTACGG TAGGGGCGAACCTGCTTGCC TTGGCAGTGT 251 TGGGAAAGTT GTCCCCGTGG CGGATAGGGG GAAAAGGGAAGGGCGTTTCG 301 GTCGGCGTGT CGGGCAGTGT GAGGCAGCTC GGATGCGTAC TGCTCGGTTT351 TGTGTCCGGC AAATTGATGT GCGATATTTG GATGCCGTCT GAAAACGCGG 401GTATGTACTG CCTGATGCTG CTGGTGTTCC TCATCGGCGT ACAGCTCAAA 451 AGTAGCGGCGTATCGTTGCG GCAGGTTTTG CTTAACCGGC GGGGCATCCG 501 GCTGTCGGTT TGGTTTATATTGTCATCTCT TTCAGGCGGG CTGCTGTTTG 551 CCGCATCGGC AGATGGTGTG TCGTGGACGAAAGGTTTGGC GATGGCTTCC 601 GGCTTCGGTT GGTATTCCCT CTCGGGTTTG GTAATGACCGAGGCTTACGG 651 GGCGGTATGG GGCAGCATCA TGCTGCTGAA CGATTTGGCA CGAGAGCTGT701 TTGCACTGGC ATTTATTCCG CTGCTGATGA AGCGTTTTCC GGATGCGGCG 751GTGGGGGTCG GCGGCGCGAC CAGTATGGAT TTCACATTGC CCGTAATTCA 801 GGGTGCGGGCGGTTTGGAAG TCGTGCCGGT AGCGGTCAGC TTCGGCGTGG 851 TGGTCAATAT CGCCGCCCCGTTTCTGATGG TGGTGTTTTC CACGCTGGGC 901 TGAThis corresponds to the amino acid sequence <SEQ ID 2332; ORF 700>:

g700.pep 1 MSSLMTLFSV LVPMFAGFFI RVPKPYLPAS DKVLSVLVYA VLLLIGVSLS 51RVEDLGSRLG DMALTVLWLF VCTVGANLLA LAVLGKLSPW RIGGKGKGVS 101VGVSGSVRQL GCVLLGFVSG KLMCDIWMPS ENAGMYCLML LVFLIGVQLK 151 SSGVSLRQVLLNRRGIRLSV WFILSSLSGG LLFAASADGV SWTKGLAMAS 201 GFGWYSLSGL VMTEAYGAVWGSIMLLNDLA RELFALAFIP LLMKRFPDAA 251 VGVGGATSMD FTLPVIQGAGGLEVVPVAVS FGVVVNIAAP FLMVVFSTLG 301 *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2333>:

m700.seq 1 ATGGACAGCC TGATGACGTT GCTTTCGGTA TTGATACCGA TGTTTGCCGG 51ATTTTTTATC CGTGTGCCCA AGCCTTACCT GCCCGCTTTG GATAAGGTGC 101TATCGGTCTT GGTGTATGCT GTGCTGCTGC TGATCGGCGT CTCGTTGTCG 151CGCGTGGAGG ATTTGGGTTC GCGGTTGGAC GATATGGCGT TGACGGTTCT 201GTGGCTGTTT GTTTGTACGG TCGGGGCGAA CCTGCTTGCT TTGGCAGTGT 251TGGGAAAGTT ATTCCCGTGG CGGATAAAGG GGAAAGGGAA GGGCGTTTCG 301GTCGGCGTGT CGGGCAGTGT GGGGCAGCTC GGATGCGTGC TGCTCGGATT 351TGCATTCGGC AAACTGATGC GCGATATTTG GATGCCGTCT GAAAGCGCGG 401GCATGTATTG TCTGATGCTG CTGGTGTTCC TCATCGGCGT ACAGCTCAAA 451AGCAGCGGCG TATCGTTGCG GCAGGTTTTG GTCAACCGCA GGGGTATTCG 501GTTGTCGGTC TGGTTTATGC TTTCATCTCT TTCGGGCGGG CTGCTGTTTG 551CCGCATCGAC AGACGGTGTG TCGTGGACGA AAGGTTTGGC GATGGCTTCC 601GGCTTCGGTT GGTATTCCCT CTCGGGTTTG GTCATGACCG AGGCTTACGG 651CGCGGTATGG GGCAGCATCA TGCTGCTGAA CGATTTGGCA CGAGAGCTGT 701TTGCACTGGC ATTTATCCCG CTGCTGATGA AGCGTTTTCC AGATGCGGCG 751GTGGGGGTTG GCGGTGCGAC CAGTATGGAT TTTACATTGC CCGTGATTCA 801GGGTGCGGGC GGTTTGGAAG TCGTGCCGGT AGCGGTCAGC TTCGGCGTGG 851TGGTCAATAT CGCCGCCCCG TTTCTGATGG TGGTGTTTTC CGCTTTGGGT 901 TGAThis corresponds to the amino acid sequence <SEQ ID 2334; ORF 700>:

m700.pep 1 MDSLMTLLSV LIPMFAGFFI RVPKPYLPAL DKVLSVLVYA VLLLIGVSLS 51RVEDLGSRLD DMALTVLWLF VCTVGANLLA LAVLGKLFPW RIKGKGKGVS 101VGVSGSVGQL GCVLLGFAFG KLMRDIWMPS ESAGMYCLML LVFLIGVQLK 151SSGVSLRQVL VNRRGIR LSV WFMLSSLSGG LLFAASTDGV SWTKGLAMAS 201GFGWYSLSGL VMTEAYGAVW GSIMLLNDLA RELFALAFIP LLMKRFPDAA 251VGVGGATSMD FTLPVIQGAG GLEVVPVAVS FGVVVNIAAP FLMVVFSALG 301 *Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 700 shows 94.7% identity over a 300 aa overlap with a predicted ORF(ORF700.ng) from N. gonorrhoeae:

m700/g700         10        20        30        40        50        60m700.pep MDSLMTLLSVLIPMFAGFFIRVPKPYLPALDKVLSVLVYAVLLLIGVSLSRVEDLGSRLD|:|||||:|||:||||||||||||||||| ||||||||||||||||||||||||||||| g700MSSLMTLFSVLVPMFAGFFIRVPKPYLPASDKVLSVLVYAVLLLIGVSLSRVEDLGSRLG        10        20        30        40        50        60        70        80        90       100       110       120 m700.pepDMALTVLWLFVCTVGANLLALAVLGKLFPWRIKGKGKGVSVGVSGSVGQLGCVLLGFAFG|||||||||||||||||||||||||||10 |||| |||||||||||||| |||||||||: | g700DMALTVLWLFVCTVGANLLALAVLGKLSPWRIGGKGKGVSVGVSGSVRQLGCVLLGFVSG        70        80        90       100       110       120       130       140       150       160       170       180 m700.pepKLMRDIWMPSESAGMYCLMLLVFLIGVQLKSSGVSLRQVLVNRRGIRLSVWFMLSSLSGG ||||||||||:||||||||||||||||||||||||||||:|||||||||||:||||||| g700KLMCDIWMPSENAGMYCLMLLVFLIGVQLKSSGVSLRQVLLNRRGIRLSVWFILSSLSGG       130       140       150       160       170       180       190       200       210       220       230       240 m700.pepLLFAASTDGVSWTKGLAMASGFGWYSLSGLVMTEAYGAVWGSIMLLNDLARELFALAFIP||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||| g700LLFAASADGVSWTKGLAMASGFGWYSLSGLVMTEAYGAVWGSIMLLNDLARELFALAFIP       190       200       210       220       230       240       250       260       270       280       290       300 m700.pepLLMKRFPDAAVGVGGATSMDFTLPVIQGAGGLEVVPVAVSFGVVVNIAAPFLMVVFSALG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| g700LLMKRFPDAAVGVGGATSMDFTLPVIQGAGGLEVVPVAVSFGVVVNIAAPFLMVVFSTLG       250       260       270       280       290       300 m700.pep X| g700 XThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2335>:

a700.seq 1 ATGGACAGCC TGATGACGTT GCTTTCGGTA TTGATACCGA TGTTTGCCGG 51ATTTTTTATC CGTGTGCCCA AGCCTTACCT GCCCGCTTTG GATAAGGTGC 101TATCGGTCTT GGTGTATGCT GTGCTGCTGC TGATCGGCGT CTCGTTGTCG 151CGCGTGGAGG ATTTGGGTTC GCGGTTGGAC GATATGGCGT TGACGGTTCT 201GTGGCTGTTT GTTTGTACGG TCGGGGCGAA CCTGCTTGCT TTGGCAGTGT 251TGGGAAAGTT ATTCCCGTGG CGGATAAAGG GGAAAGGGAA GGGCGTTTCG 301GTCGGTGTGT CGGGCAGTGT GGGGCAGCTC GGATGCGTGC TGCTCGGATT 351TGCATCCGGC AAACTGATGC GCGATATTTG GATGCCGTCT GAAAACGCGG 401GTATGTATTG TCTGATGCTG CTGGTGCTCN TCATCGGCGT ACAGCTCAAA 451AGCAGCGGCG TATCGTTGCG GCAGGTTTTG GTCAACCGCA GGGGTATTCG 501GTTGTCGGTC TGGTTTATGC TTTCATCTCT TTCAGGCGGG CTGCTGTTTG 551CCGCATCGGC AGACGGTGTG TCGTGGGTGA AAGGTTTGGC GATGGCTTCC 601GGCTTCGGTT GGTATTCCCT CTCGGGTTTG GTGATGACCG AGGCTTACGG 651CGCGGTATGG GGCAGTATCG CGCTTTTGAA CGATTTGGCA CGAGAGCTGT 701TCGCGCTGGC ATTTATTCCG CTGCTGATGA AGCGTTTTCC CGATGCGGCA 751GTGGGGGTCG GCGGCGCGAC CAGTATGGAT TTCACATTGC CCGTGATTCG 801GGGTGCGGGC GGCTTGGAAG CCGTACCGGT AGCGGTCAGC TTCGGCGTGG 851TGGTCAATAT CGCCGCTCCG TTTCTGATGG TGGTGTTTTC CGCTTTGGGC 901 TGAThis corresponds to the amino acid sequence <SEQ ID 2336; ORF 700.a>:

a700.pep 1 MDS LMTLLSV LIPMFAGFFI RVPKPYLPAL DKVLSVLVYA VLLLIGVSLS 51RVEDLGSRLD DMALTVLW LF VCTVGANLLA LAVLGKLFPW RIKGKGKGVS 101 VGVSGSVGQL GCVLLGFASG KLMRDIWMPS EN AGMYCLML LVLXIGVQLK 151SSGVSLRQVL VNRRGIRLSV WFMLSSLSGG LLFAASADGV SWVKGLAMAS 201GFGWYSLSGL VMTEAYGAVW GSIALLNDLA RELFALAFIP LLMKRFPDAA 251VGVGGATSMD FTLPVIRGAG GLEAVPVAVS FG VVVNIAAP FLMVVFSALG 301 * m700/a70097.0% identity in 300 aa overlap        10        20        30        40        50        60 m700.pepMDSLMTLLSVLIPMFAGFFIRVPKPYLPALDKVLSVLVYAVLLLIGVSLSRVEDLGSRLD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a700MDSLMTLLSVLIPMFAGFFIRVPKPYLPALDKVLSVLVYAVLLLIGVSLSRVEDLGSRLD        10        20        30        40        50        60        70        80        90       100       110       120 m700.pepDMALTVLWLFVCTVGANLLALAVLGKLFPWRIKGKGKGVSVGVSGSVGQLGCVLLGFAFG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| | a700DMALTVLWLFVCTVGANLLALAVLGKLFPWRIKGKGKGVSVGVSGSVGQLGCVLLGFASG        70        80        90       100       110       120       130       140       150       160       170       180 m700.pepKLMRDIWMPSESAGMYCLMLLVFLIGVQLKSSGVSLRQVLVNRRGIRLSVWFMLSSLSGG|||||||||||:||||||||||: |||||||||||||||||||||||||||||||||||| a700KLMRDIWMPSENAGMYCLMLLVLXIGVQLKSSGVSLRQVLVNRRGIRLSVWFMLSSLSGG       130       140       150       160       170       180       190       200       210       220       230       240 m700.pepLLFAASTDGVSWTKGLAMASGFGWYSLSGLVMTEAYGAVWGSIMLLNDLARELFALAFIP||||||:|||||:|||||||||||||||||||||||||||||| |||||||||||||||| a700LLFAASADGVSWVKGLAMASGFGWYSLSGLVMTEAYGAVWGSIALLNDLARELFALAFIP       190       200       210       220       230       240       250       260       270       280       290       300 m700.pepLLMKRFPDAAVGVGGATSMDFTLPVIQGAGGLEVVPVAVSFGVVVNIAAPFLMVVFSALG||||||||||||||||||||||||||:||||||:|||||||||||||||||||||||||| a700LLMKRFPDAAVGVGGATSMDFTLPVIRGAGGLEAVPVAVSFGVVVNIAAPFLMVVFSALG       250       260       270       280       290       300 m700.pep X| a700 XThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2337>:

g701.seq 1 ATGTCTTGGC ACATATTCCA AGTTGCAGGG ATACCGACCG CTTCGATGGC 51ACAATCTACG CCGTCTTCGC CGACGATGGC GAAAACTTGT TTGGAGACGT 101CGCCGGAAGC GGGGCTGATG GTATGGGTCG CGCCCAACTC TTTCGCCGGT 151TTCAAACGGT TTTCGTCCAT ATCGCACACG ATAATGGCGG CAGGGCTATA 201CAGTTGGGCG GTCAACAAGG CGGACATACC GACAGGGCCG GCACCTGCGA 251TGAATACGGT ATCGCCGGGT TTCACATCGC CGTATTGCAC GCCGATTTCG 301TGGGCGGTCG GTAAAGCGTC GCTCAACAGC AGGGCGATTT CTTCGTTGAC 351GTTGTCGTGC GGCGGCACGA GGCTGTTGTC GGCATAAThis corresponds to the amino acid sequence <SEQ ID 2338; ORF 701>:

g701.pep 1 10 MSWHIFQVAG IPTASMAQST PSSPTMAKTC LETSPEAGLM VWVAPNSFAG 51FKRFSSISHT IMAAGLYSWA VNKADIPTGP APAMNTVSPG FTSPYCTPIS 101WAVGKASLNS RAISSLTLSC GGTRLLSA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2339>:

m701.seq 1 ATGTCTTGGC ACATATTCCA TGTAGCAGGG ATACCGACGG CTTCGATGGC 51GCAATCCACG CCGTCTTCGC CGACGATGGC AAAGACTTGT TTGGATACTT 101CGCCGGAAGC AGGGTTAATG GTATGGGTCG CACCCAATTC TTTCGCCAGT 151TTCAAACGGT TTTCGTCCAT ATCGCAAACG ATGATGGCGG CGGGACTGTA 201CAGTTGGGCG GTCAACAGGG CGGACATACC GACAGGGCCT GCCCCAGCGA 251TGAATACGGT GTCGCCGGGT TTGACATCGC CGTATTGCAC GCCGATTTCG 301TGGGCGGTCG GCAAAGCGTC GCTCAACAAC AGGGCGATTT CTTCGTTGAC 351ATTATCGGGC AGCGGAACGA GGCTGTTGTC GGCATAAThis corresponds to the amino acid sequence <SEQ ID 2340; ORF 701>:

m701.pep 1 MSWHIFHVAG IPTASMAQST PSSPTMAKTC LDTSPEAGLM VWVAPNSFAS 51FKRFSSISQT MMAAGLYSWA VNRADIPTGP APAMNTVSPG LTSPYCTPIS 101WAVGKASLNN RAISSLTLSG SGTRLLSA*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 701 shows 92.2% identity over a 128 aa overlap with a predicted ORF(ORF701.a) from N. gonorrhoeae:

m701/g701         10        20        30        40        50        60m701.pep MSWHIFHVAGIPTASMAQSTPSSPTMAKTCLDTSPEAGLMVWVAPNSFASFKRFSSISQT||||||:||||||||||||||||||||||||:|||||||||||||||||:||||||||:| g701MSWHIFQVAGIPTASMAQSTPSSPTMAKTCLETSPEAGLMVWVAPNSFAGFKRFSSISHT        10        20        30        40        50        60        70        80        90       100       110       120 m701.pepMMAAGLYSWAVNRADIPTGPAPAMNTVSPGLTSPYCTPISWAVGKASLNNRAISSLTLSG:|||||||||||:|||||||||||||||||:||||||||||||||||||:||||||||| g701IMAAGLYSWAVNKADIPTGPAPAMNTVSPGFTSPYCTPISWAVGKASLNSRAISSLTLSC        70        80        90       100       110       120       129m701.pep SGTRLLSAX :|||||||| g701 GGTRLLSAXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2341>:

a701.seq 1 ATGTCTTGGC ACATATTCCA AGTTGCAGGG ATACCGACGG CTTCGATCGC 51GCAGTCCACG CCGTCTTCGC CGACGATAGC GGCAACTTGC TTGCTTACAT 101CGCCGGAAGC AGGGTTAATG GTATGGGTTG CGCCCAACTC TTTCGCCAGT 151TTCAAACGGT TTTCGTCCAT ATCGCAAACA ATGATGGCGG CGGGGCTGTA 201CAGTTGGGCG GTCGGCAAGG CGGACATACC GACAGGAGCG GCACCTGCGA 251TGAATACGGT GTCGCCGGGT TTGACATCGC CGTATTGCAC GCCGATTTCG 301TGTGCGGTCG GCAAAGCGTC GCTCAACAAC AGGGCGACTT CTTCGTTGAC 351GTTGTCGGGC AGCGGCACGA GGCTGTTGTC GGCATAAThis corresponds to the amino acid sequence <SEQ ID 2342; ORF 701.a>:

a701.pep 1 10 MSWHIFQVAG IPTASIAQST PSSPTIAATC LLTSPEAGLM VWVAPNSFAS 51FKRFSSISQT MMAAGLYSWA VGKADIPTGA APAMNTVSPG LTSPYCTPIS 101CAVGKASLNN RATSSLTLSG SGTRLLSA* m701/a70192.2% identity in 128 aa overlap        10        20        30        40        50        60 m701.pepMSWHIFHVAGIPTASMAQSTPSSPTMAKTCLDTSPEAGLMVWVAPNSFASFKRFSSISQT||||||:||||||||:|||||||||:| ||| |||||||||||||||||||||||||||| a701MSWHIFQVAGIPTASIAQSTPSSPTIAATCLLTSPEAGLMVWVAPNSFASFKRFSSISQT        10        20        30        40        50        60        70        80        90       100       110       120 m701.pepMMAAGLYSWAVNRADIPTGPAPAMNTVSPGLTSPYCTPISWAVGKASLNNRAISSLTLSG|||||||||||::|||||| |||||||||||||||||||| ||||||||||| ||||||| a701MMAAGLYSWAVGKADIPTGAAPAMNTVSPGLTSPYCTPISCAVGKASLNNRATSSLTLSG        70        80        90       100       110       120       129m701.pep SGTRLLSAX ||||||||| a701 SGTRLLSAXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2343>:

g702.seq 1 ATGCCGTGTt ccaAAGCCAG TTGGACTTCG CCCGGAGtgg cAACGCCGGG 51AATCAGGGGA ATGCCGCTGT TGCGGCCGGC TCTGGCGAGG GATTCGTGCA 101AACCCGGGCT GATGGCGAAA ACCGCGCCTG CGTCTTCGAC GGCTTTGAGC 151TGTTCGGGAT TGGTTACCGT ACCTGCGCCG ATGATGGCGT TGGGCATTTC 201TTTGGCAATC AGGCGGATGG CCTCGAGTCC GACGGGGGTG CGCAAGGTAA 251TTTCGAGGGT GGGGATGCCG CCTTCGACAA GGGCGCGGGA CAAATCGACG 301GCGGTGCTTA AGTCGTCAAt cgCCATCACA GGCACAACTG CGCCGGCGGT 351CAGGATTTCG cggggggtca gttgaThis corresponds to the amino acid sequence <SEQ ID 2344; ORF 702>:

g702.pep 1 MPCSKASWTS PGVATPGIRG MPLLRPALAR DSCKPGLMAK TAPASSTALS 51CSGLVTVPAP MMALGISLAI RRMASSPTGV RKVISRVGMP PSTRARDKST 101AVLKSSIAIT GTTAPAVRIS RGVS*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2345>:

m702.seq 1 ATGCCGTGTT CCAAAGCCAG TTGGATTTCG CCCGGGGTGG CAACACCGGG 51AATCAGGGGG ATGCCGCTGT TGTGGCCGGC TTTGGCGAGG GATTCATGCA 101GCCCCGGGCT GATGGCGAAA ACCGCGCCTG CGTCTTCGAC GGCTTTGAGC 151TGTTCGGGAT TGGTTACCGT ACCTGCGCCG ACGATGGCGT TGGGCACTTC 201TTTGGCAATC AGGCGGATGG CATCGAGGCC GACAGGGGTG CGCAGGGTGA 251TTTCGAGGGT AGGGATGCCG CCTTCGACAA GGGCGTGGGA CAAATCGATG 301GCGGTGCTTA AGTCGTCAAT CGCCATTACC GGCACAACTG CGCCGGCGGT 351CAAAATTTCG CGGGGGGTCA GTTTGGACAT TTCGGTTCTC CGGGTGGAAT 401GGGGTATTTT ATTAAGATGG GACAGGTTGT AGThis corresponds to the amino acid sequence <SEQ ID 2346; ORF 702>:

m702.pep 1 MPCSKASWIS PGVATPGIRG MPLLWPALAR DSCSPGLMAK TAPASSTALS 51CSGLVTVPAP TMALGTSLAI RRMASRPTGV RRVISRVGMP PSTRAWDKSM 101 AVLKSSIAITGTTAPAVKIS RGVSLDISVL RVEWGILLRW DRL*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 702 shows 91.9% identity over a 124 aa overlap with a predicted ORF(ORF702.a) from N. gonorrhoeae:

m702/g702         10        20        30        40        50        60m702.pep MPCSKASWISPGVATPGIRGMPLLWPALARDSCSPGLMAKTAPASSTALSCSGLVTVPAP|||||||| ||||||||||||||| ||||||||:|||||||||||||||||||||||||| g702MPCSKASWTSPGVATPGIRGMPLLRPALARDSCKPGLMAKTAPASSTALSCSGLVTVPAP        10        20        30        40        50        60        70        80        90       100       110       120 m702.pepTMALGTSLAIRRMASRPTGVRRVISRVGMPPSTRAWDKSMAVLKSSIAITGTTAPAVKIS |||| ||||||||| |||||:||||||||||||| ||| |||||||||||||||||:|| g702MMALGISLAIRRMASSPTGVRKVISRVGMPPSTRARDKSTAVLKSSIAITGTTAPAVRIS        70        80        90       100       110       120       130       140 m702.pep RGVSLDISVLRVEWGILLRWDRLX |||| g702 RGVSXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2347>:

a702.seq 1 ATGCCGTGTT CCAAAGCCAG TTGGATTTCG CCCGGGGTGG CAACACCGGG 51AATCAGGGGG ATGCCGCTGT TGTGGCCGGC TTTGGCGAGG GATTCATGCA 101 GCCCCGGGCTGATGGCGAAA ACCGCGCCTG CGTCTTCGAC GGCTTTGAGC 151 TGTTCGGGAT TGGTTACCGTACCTGCGCCG ACGATGGCGT TGGGCACTTC 201 TTTGGCAATC AGGCGGATGG CATCGAGGCCGACAGGGGTG CGCAGGGTGA 251 TTTCGAGGGT AGGGATGCCG CCTTCGACAA GGGCGTGGGACAAATCGATG 301 GCGGTGCTTA AGTCGTCAAT CGCCATTACC GGCACAACTG CGCCGGCGGT351 CAAAATTTCG CGGGGGGTCA GTTTGGACAT TTCGGTTCTC CGGGTGGAAT 401GGGGTATTTT ATTAAGATGG GACAGGTTGT AGThis corresponds to the amino acid sequence <SEQ ID 2348; ORF 702.a>:

a702.pep 1 MPCSKASWIS PGVATPGIRG MPLLWPALAR DSCSPGLMAK TAPASSTALS 51CSGLVTVPAP TMALGTSLAI RRMASRPTGV RRVISRVGMP PSTRAWDKSM 101 AVLKSSIAITGTTAPAVKIS RGVSLDISVL RVEWGILLRW DRL* m702/a702 100.0% identity in 143aa overlap         10        20        30        40        50        60m702.pep MPCSKASWISPGVATPGIRGMPLLWPALARDSCSPGLMAKTAPASSTALSCSGLVTVPAP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a702MPCSKASWISPGVATPGIRGMPLLWPALARDSCSPGLMAKTAPASSTALSCSGLVTVPAP        10        20        30        40        50        60        70        80        90       100       110       120 m702.pepTMALGTSLAIRRMASRPTGVRRVISRVGMPPSTRAWDKSMAVLKSSIAITGTTAPAVKIS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a702TMALGTSLAIRRMASRPTGVRRVISRVGMPPSTRAWDKSMAVLKSSIAITGTTAPAVKIS        70        80        90       100       110       120       130       140 m702.pep RGVSLDISVLRVEWGILLRWDRLX|||||||||||||||||||||||| a702 RGVSLDISVLRVEWGILLRWDRLX       130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2349>:

g703.seq 1 ATGAAAGCAA AAATCCTGAC TTCCGTTGCG CTGCTTGCCT GTTCCGGCAG 51CCTGTTTGCC CAAACGCTGG CAACCGTTAA CGGTCAGAAA ATCGACAGTT 101 CCGTCATCGATGCGCAGGTT GCCGCATTCC GTGCGGAAAA CAGCCGTGCC 151 GAAGACACGC CGCAACTGCGCCAATCCCTG CTGGAAAACG AAGTGGTCAA 201 CACCGTGGTC GCACAGGAAG TGAAACGCCTGAAACTCGAC CGGTCGGCAG 251 AGTTTAAAGA TGCGCTTGCC AAATTGCGTG CCGAAGCGAAAAAGTCGGGC 301 GACGACAAGA AACCGTCCTT CAAAACCGTT TGGCAGGCGG TAAAATATGG351 CTTGAACGGC GAGGCATACG CACTGCATAT CGCCAAAACC CAACCGGTTT 401CCGAGCAGGA AGTAAAAGCC GTTTACGACA ATATCAGCGG TTTTTATAAA 451 GGCACGCAGGAAGTCCAGTT GGGCGAAATC CTGACCGACA AGGAAGAAAA 501 TGCGAAAAAA GCGGTTGCCGATTTGAAGGC GAAAAAAGGT TTTGATGCCG 551 TTTTGAAACA ATACTCGCTC AACGACCGCACCAAACGGAC CGGCGCGCCG 601 GACGGATATG TGCCGCTGAA AGATTTGGAA CAGGGTGTTCCGCCGCTTTA 651 TCAGGCAATT AAGGACTTGA AAAAAGGCGA ATTTACGGCA ACGCCGCTGA701 AAAACGGCGA TTTCTACGGC GTTTATTATG TCAACGACAG CCGcgaggTG 751AAAGTGCCTT CTTTTGACGA AATGAAAGGA CAGATTGCCG GCAACCTTCA 801 GGCGGAACGGATTGACCGTG CCGTctgTGc gcTGTTgggt aaggCAAACA 851 TCAAACCTGC AAAATAAThis corresponds to the amino acid sequence <SEQ ID 2350; ORF 703>:

g703.pep 1 MKAKILTSVA LLACSGSLFA QTLATVNGQK IDSSVIDAQV AAFRAENSRA 51EDTPQLRQSL LENEVVNTVV AQEVKRLKLD RSAEFKDALA KLRAEAKKSG 101 DDKKPSFKTVWQAVKYGLNG EAYALHIAKT QPVSEQEVKA VYDNISGFYK 151 GTQEVQLGEI LTDKEENAKKAVADLKAKKG FDAVLKQYSL NDRTKRTGAP 201 DGYVPLKDLE QGVPPLYQAI KDLKKGEFTATPLKNGDFYG VYYVNDSREV 251 KVPSFDEMKG QIAGNLQAER IDRAVCALLG KANIKPAK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2351>:

m703.seq 1 ATGAAAGCAA AAATCCTGAC TTCCGTTGCA CTGCTTGCCT GTTCCGGCAG 51CCTGTTTGCC CAAACGCTGG CAACCGTCAA CGGTCAGAAA ATCGACAGTT 101 CCGTCATCGATGCGCAGGTT GCCGCATTCC GTGCGGAAAA CAGCCGTGCC 151 GAAGACACGC CGCAACTGCGCCAATCCCTG CTGGAAAACG AAGTGGTCAA 201 TACCGTGGTC GCACAGGAAG TGAAACGCCTGAAACTCGAC CGGTCGGCAG 251 AGTTTAAAAA TGCGCTTGCC AAATTGCGTG CCGAAGCGAAAAAGTCGGGC 301 GACGACAAGA AACCGTCCTT CAAAACCGTT TGGCAGGCGG TAAAATATGG351 CTTGAACGGC GAGGCATACG CATTGCATAT CGCCAAAACC CAACCGGTTT 401CCGAGCAGGA AGTAAAAGCC GCATATGACA ATATCAGCGG TTTTTACAAA 451 GGTACGCAGGAAGTCCAGTT GGGCGAAATC CTGACCGACA AGGAAGAAAA 501 TGCAAAAAAA GCGGTTGCCGACTTGAAGGC GAAAAAAGGT TTCGATGCCG 551 TCTTGAAACA ATATTCCCTC AACGACCGTACCAAACAGAC CGGTGCGCCG 601 GTCGGATATG TGCCGCTGAA AGATTTGGAA CAGGGTGTTCCGCCGCTTTA 651 TCAGGCAATT AAGGACTTGA AAAAAGGCGA ATTTACGGCA ACGCCGCTGA701 AAAACGGCGA TTTCTACGGC GTTTATTATG TCAACGACAG CCGCGAGGTA 751AAAGTGCCTT CTTTTGATGA AATGAAAGGA CAGATTGCGG GCAACCTTCA 801 GGCGGAACGGATTGACCGTG CCGTCGGTGC ACTGTTGGGC AAGGCAAACA 851 TCAAACCTGC AAAATAAThis corresponds to the amino acid sequence <SEQ ID 2352; ORF 703>:

m703.pep 1 MKAKILTSVA LLACSGSLFA QTLATVNGQK IDSSVIDAQV AAFRAENSRA 51EDTPQLRQSL LENEVVNTVV AQEVKRLKLD RSAEFKNALA KLRAEAKKSG 101 DDKKPSFKTVWQAVKYGLNG EAYALHIAKT QPVSEQEVKA AYDNISGFYK 151 GTQEVQLGEI LTDKEENAKKAVADLKAKKG FDAVLKQYSL NDRTKQTGAP 201 VGYVPLKDLE QGVPPLYQAI KDLKKGEFTATPLKNGDFYG VYYVNDSREV 251 KVPSFDEMKG QIAGNLQAER IDRAVGALLG KANIKPAK*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 703 shows 98.3% identity over a 288 aa overlap with a predicted ORF(ORF703.a) from N. gonorrhoeae:

m703/g703         10        20        30        40        50        60m703.pep MKAKILTSVALLACSGSLFAQTLATVNGQKIDSSVIDAQVAAFRAENSRAEDTPQLRQSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g703MKAKILTSVALLACSGSLFAQTLATVNGQKIDSSVIDAQVAAFRAENSRAEDTPQLRQSL        10        20        30        40        50        60        70        80        90       100       110       120 m703.pepLENEVVNTVVAQEVKRLKLDRSAEFKNALAKLRAEAKKSGDDKKPSFKTVWQAVKYGLNG||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| g703LENEVVNTVVAQEVKRLKLDRSAEFKDALAKLRAEAKKSGDDKKPSFKTVWQAVKYGLNG        70        80        90       100       110       120       130       140       150       160       170       180 m703.pepEAYALHIAKTQPVSEQEVKAAYDNISGFYKGTQEVQLGEILTDKEENAKKAVADLKAKKG||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||| g703EAYALHIAKTQPVSEQEVKAVYDNISGFYKGTQEVQLGEILTDKEENAKKAVADLKAKKG       130       140       150       160       170       180       190       200       210       220       230       240 m703.pepFDAVLKQYSLNDRTKQTGAPVGYVPLKDLEQGVPPLYQAIKDLKKGEFTATPLKNGDFYG|||||||||||||||:|||| |||||||||||||||||||||||||||||||||||||| g703FDAVLKQYSLNDRTKRTGAPDGYVPLKDLEQGVPPLYQAIKDLKKGEFTATPLKNGDFYG       190       200       210       220       230       240       250       260       270       280      289 m703.pepVYYVNDSREVKVPSFDEMKGQIAGNLQAERIDRAVGALLGKANIKPAKX|||||||||||||||||||||||||||||||||||| ||||||||||||| g703VYYVNDSREVKVPSFDEMKGQIAGNLQAERIDRAVCALLGKANIKPAKX       250       260       270       280The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2353>:

a703.seq 1 ATGAAAGCAA AAATCCTGAC TTCCGTTGCA CTGCTTGCCT GTTCCGGCAG 51CCTGTTTGCC CAAACGCTGG CAACCGTCAA CGGTCAGAAA ATCGACAGTT 101 CCGTCATTGATGCGCAGGTT GCCGCATTCC GTGCGGAAAA CAGCCGTGCC 151 GAAGACACGC CGCAACTGCGCCAATCCCTG CTGGAAAACG AAGTGGTCAA 201 CACCGTGGTC GCACAGGAAG TGAAACGCCTGAAACTCGAC CGGTCGGCAG 251 AGTTTAAAAA TGCGCTTGCC AAATTGCGTG CCGAAGCGAAAAAGTCGGGC 301 GACGACAAGA AACCGTCCTT CAAAACCGTT TGGCAGGCGG TAAAATATGG351 CTTGAACGGC GAGGCATACG CGCTGCATAT CGCCAAAACC CAACCGGTTT 401CCGAGCAGGA AGTAAAAGCC GCATATGACA ATATCAGCGG TTTTTACAAA 451 GGTACGCAGGAAGTCCAGTT GGGCGAAATC CTGACCGACA AGGAAGAAAA 501 TGCAAAAAAA GCGGTTGCCGACTTGAAGGC GAAAAAAGGT TTCGATGCCG 551 TCTTGAAACA ATATTCCCTC AACGACCGTACCAAACAGAC CGGTGCGCCG 601 GTCGGATATG TGCCGCTGAA AGATTTGGAA CAGGGTGTTCCGCCGCTTTA 651 TCAGGCAATT AAGGACTTGA AAAAAGGCGA ATTTACGGCA ACGCCGCTGA701 AAAACGGCGA TTTCTACGGC GTTTATTATG TCAACGACAG CCGCGAGGTA 751AAAGTGCCTT CTTTTGATGA AATGAAAGGA CAGATTGCGG GCAACCTTCA 801 GGCGGAACGGATTGACCGTG CCGTCGGTGC ACTGTTGGGC AAGGCAAACA 851 TCAAACCTGC AAAATAAThis corresponds to the amino acid sequence <SEQ ID 2354; ORF 703.a>:

a703.pep 1 MKAKILTSVA LLACSGSLFA QTLATVNGQK IDSSVIDAQV AAFRAENSRA 51EDTPQLRQSL LENEVVNTVV AQEVKRLKLD RSAEFKNALA KLRAEAKKSG 101 DDKKPSFKTVWQAVKYGLNG EAYALHIAKT QPVSEQEVKA AYDNISGFYK 151 GTQEVQLGEI LTDKEENAKKAVADLKAKKG FDAVLKQYSL NDRTKQTGAP 201 VGYVPLKDLE QGVPPLYQAI KDLKKGEFTATPLKNGDFYG VYYVNDSREV 251 KVPSFDEMKG QIAGNLQAER IDRAVGALLG KANIKPAK*m703/a703 100.0% identity in 288 aa overlap        10        20        30        40        50        60 m703.pepMKAKILTSVALLACSGSLFAQTLATVNGQKIDSSVIDAQVAAFRAENSRAEDTPQLRQSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a703MKAKILTSVALLACSGSLFAQTLATVNGQKIDSSVIDAQVAAFRAENSRAEDTPQLRQSL        10        20        30        40        50        60        70        80        90       100       110       120 m703.pepLENEVVNTVVAQEVKRLKLDRSAEFKNALAKLRAEAKKSGDDKKPSFKTVWQAVKYGLNG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a703LENEVVNTVVAQEVKRLKLDRSAEFKNALAKLRAEAKKSGDDKKPSFKTVWQAVKYGLNG        70        80        90       100       110       120       130       140       150       160       170       180 m703.pepEAYALHIAKTQPVSEQEVKAAYDNISGFYKGTQEVQLGEILTDKEENAKKAVADLKAKKG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a703EAYALHIAKTQPVSEQEVKAAYDNISGFYKGTQEVQLGEILTDKEENAKKAVADLKAKKG       130       140       150       160       170       180       190       200       210       220       230       240 m703.pepFDAVLKQYSLNDRTKQTGAPVGYVPLKDLEQGVPPLYQAIKDLKKGEFTATPLKNGDFYG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a703FDAVLKQYSLNDRTKQTGAPVGYVPLKDLEQGVPPLYQAIKDLKKGEFTATPLKNGDFYG       190       200       210       220       230       240       250       260       270       280      289 m703.pepVYYVNDSREVKVPSFDEMKGQIAGNLQAERIDRAVGALLGKANIKPAKX||||||||||||||||||||||||||||||||||||||||||||||||| a703VYYVNDSREVKVPSFDEMKGQIAGNLQAERIDRAVGALLGKANIKPAKX       250       260       270       280The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2355>:

a704.seq 1 ATGAAAAAAA CCTGTTTCCA CTGCGGGCTG GACGTTCCCG AAAACCTGCA 51TCTGACCGTC CGTTACGAAA ACGAAGACCG CGAAACCTGC TGCGCCGGTT 101 GTCAGGCAGTCGCACAAAGC ATTATTGACG CGGGCTTGGG CAGTTATTAC 151 AAACAACGCA CCGCCGACGCGCAAAAAACC GAGCTGCCGC CCCAAGAAAT 201 CCTCGACCAA ATCCGCCTGT ACGACCTGCCCGAAGTCCAG TCCGACTTTG 251 TGGAAACCCA CGGCGGCACG CGCGAGGCGG TTTTAATGCTCGGCGGCATC 301 ACCTGCGCCG CCTGCGTCTG GCTGATCGAA CAGCAGCTTT TGCGTACAGA351 CGGCATCGTC CGCATCGACC TCAATTACAG CACGCACCGC TGCCGCGTCG 401TCTGGGACGA CGGCAAAATC CGCCTTTCCG ACATTCTGTT GAAAATCAGG 451 CAGATAGGCTACACCGCCGC ACCCTATGAC GCGCAAAAAA TCGAAGCCGC 501 CAACCAAAAA GAACGCAAACAATACATCGT CCGCCTCGCC GTTGCCGGGC 551 TGGGGATGAT GCAGACGATG ATGTTCGCGCTGCCGACCTA CCTTTACGGC 601 GGCGACATCG AACCCGATTT CCTGCAAATC CTCCATTGGGGCGGCTTTTT 651 AATGGTGCTG CCCGTCGTAT TCTATTGCGC CGTCCCGTTT TATCAAGGCG701 CGCTGCGCGA CTTGAAAAAC CGCCGCGTCG GCATGGATAC GCCGATTACC 751GTCGCCATCA TCATGACCTT TATCGCCGGC GTTTACAGCC TTGCGACAAA 801 TGCGGGGCAGGGGATGTATT TCGAATCCAT CGCGATGCTG CTGTTTTTCC 851 TGCTGGGCGG ACGCTTTATGGAACACATTG CCCGCCGTAA GGCAGGCGAT 901 GCCGCCGAGA GGCTGGTGAA GCTGATTCCTGCGTTTTGCC ATCATATGCC 951 CGATTACCCC GATACGCAGG AAACCTGCGA GGCAGCTGTCGTCAAATTGA 1001 AGGCGGGCGA TATCGTGCTG GTCAAACCGG GCGAAACCAT CCCCGTTGAC1051 GGCACGGTGC TGGAAGGAAG CAGTGCCGTC AACGAATCTA TGCTGACCGG 1101CGAGAGCCTG CCCGTCGCCA AAATGCCGTC TGAAAAAGTA ACCGCCGGCA 1151 CACTCAACACGCAAAGCCCC CTGATTATAC GCACCGACCG CACCGGCGGC 1201 GGCACGCGAC TGTCGCACATCGTCCGCCTG CTCGACCGCG CCTTAGCGCA 1251 AAAACCGCGC ACTGCCGAGT TGGCGGAACAATACGCCTCG TCTTTCATAT 1301 TCGGCGAACT CCTGCTTGCC GTCCCCGTCT TCATCGGCTGGACGCTGTAC 1351 GCCGACGCGC ACACCGCATT GTGGATTACC GTCGCCCTGC TGGTCATTAC1401 CTGCCCCTGC GCCTTATCGC TTGCCACGCC GACCGCGCTG GCAGCTTCTA 1451CCGGTACGCT GGCGCGCGAA GGTATTTTAA TCGGCGGAAA GCAGGCAATC 1501 GAAACCCTCGCCCAAACCAC CGACATCATC TTCGACAAAA CCGGCACGCT 1551 GACCCAAGGC AAACCCGCCGTCCGCCGTAT CTCATTGTTG AGAGGCACAG 1601 ACGAAGCCTT TGTTCTCGCG GTGGCGCAGGCTTTAGAACA ACAGTCCGAA 1651 CATCCCCTTG CCCGCGCCAT CCTCAACTGC CGCATTTCAGACGGCAGCGT 1701 CCCCGACATC GCTATTAAAC AACGCCTCAA CCGCATCGGC GAAGGCGTGG1751 GCGCGCAACT GACCGTCAAC GGCGAAACAC AGGTTTGGGC ATTGGGCAGG 1801GCATCCTATG TCGCCGAAAT TTCAGGTAAA GAACCGCAAA CAGAAGGCGG 1851 CGGCAGCGCGGTTTACCTCG GCAGTCAAAG CGGTTTCCAA GCCGTGTTCT 1901 ACCTGCAAGA CCCGCTCAAAGACAGCGCGG CGGAGGCGGT GCGGCAGTTG 1951 GCAGGCAAAA ACCTGACGCT GCACATTCTCAGCGGCGACC GTGAAACCGC 2001 CGTTGCCGAA ACCGCACGCG CCCTGGGTGT CGCGCACTACCGCGCCCAAG 2051 CCATGCCCGA GGACAAACTG GAATACGTCA AAGCCTTGCA AAAAGAAGGG2101 AAAAAAGTGC TGATGATAGG CGACGGCATC AACGACGCGC CCGTTTTGGC 2151GCAGGCAGAC GTATCCGCCG CCGCAGCGGG CGGGACGGAT ATTGCGAGGG 2201 ACGGCGCGGACATTGTGTTA TTGAACGAAG ATTTGCGTAC CGTCGCCCAC 2251 CTGCTCGATC AGGCGCGGCGCACCCGCCAT ATTATCCGGC AAAACCTGAT 2301 ATGGGCGGGC GCGTACAATA TCATTGCCGTACCGCTTGCC GTTTTGGGCT 2351 ATGTCCAACC GTGGATAGCC GCACTGGGTA TGAGCTTCAGTTCGCTGGCG 2401 GTTTTGGGCA ACGCCCTGCG CCTTCACAAA CGGGGGAAAA TGCAGTCTGA2451 AAAAATGCCG TCCGAACAAT GAThis corresponds to the amino acid sequence <SEQ ID 2356; ORF 703>:

a704.pep 1 MKKTCFHCGL DVPENLHLTV RYENEDRETC CAGCQAVAQS IIDAGLGSYY 51KQRTADAQKT ELPPQEILDQ IRLYDLPEVQ SDFVETHGGT REAVLMLGGI 101 TCAACVWLIEQQLLRTDGIV RIDLNYSTHR CRVVWDDGKI RLSDILLKIR 151 QIGYTAAPYD AQKIEAANQKERKQYIVRLA VAGLGMMQTM MFALPTYLYG 201 GDIEPDFLQI LHWGGFLMVL PVVFYCAVPFYQGALRDLKN RRVGMDTPIT 251 VAIIMTFIAG VYSLATNAGQ GMYFESIAML LFFLLGGRFMEHIARRKAGD 301 AAERLVKLIP AFCHHMPDYP DTQETCEAAV VKLKAGDIVL VKPGETIPVD351 GTVLEGSSAV NESMLTGESL PVAKMPSEKV TAGTLNTQSP LIIRTDRTGG 401GTRLSHIVRL LDRALAQKPR TAELAEQYAS SFIFGELLLA VPVFIGWTLY 451 ADAHTALWITVALLVITCPC ALSLATPTAL AASTGTLARE GILIGGKQAI 501 ETLAQTTDII FDKTGTLTQGKPAVRRISLL RGTDEAFVLA VAQALEQQSE 551 HPLARAILNC RISDGSVPDI AIKQRLNRIGEGVGAQLTVN GETQVWALGR 601 ASYVAEISGK EPQTEGGGSA VYLGSQSGFQ AVFYLQDPLKDSAAEAVRQL 651 AGKNLTLHIL SGDRETAVAE TARALGVAHY RAQAMPEDKL EYVKALQKEG701 KKVLMIGDGI NDAPVLAQAD VSAAAAGGTD IARDGADIVL LNEDLRTVAH 751LLDQARRTRH IIRQNLIWAG AYNIIAVPLA VLGYVQPWIA ALGMSFSSLA 801 VLGNALRLHKRGKMQSEKMP SEQ* m704/a704 99.8% identity in 823 aa overlap        10        20        30        40        50        60 m704.pepMKKTCFHCGLDVPEHLHLTVRYENEDRETCCAGCQAVAQSIIDAGLGSYYKQRTADAQKT||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||| a704MKKTCFHCGLDVPENLHLTVRYENEDRETCCAGCQAVAQSIIDAGLGSYYKQRTADAQKT        10        20        30        40        50        60        70        80        90       100       110       120 m704.pepELPPQEILDQIRLYDLPEVQSDFVETHGGTREAVLMLGGITCAACVWLIEQQLLRLDGIV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a704ELPPQEILDQIRLYDLPEVQSDFVETHGGTREAVLMLGGITCAACVWLIEQQLLRLDGIV        70        80        90       100       110       120       130       140       150       160       170       180 m704.pepRIDLNYSTHRCRVVWDDGKIRLSDILLKIRQIGYTAAPYDAQKIEAANQKERKQYIVRLA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a704RIDLNYSTHRCRVVWDDGKIRLSDILLKIRQIGYTAAPYDAQKIEAANQKERKQYIVRLA       130       140       150       160       170       180       190       200       210       220       230       240 m704.pepVAGLGMMQTMMFALPTYLYGGDIEPDFLQILHWGGFLMVLPVVFYCAVPFYQGALRDLKN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a704VAGLGMMQTMMFALPTYLYGGDIEPDFLQILHWGGFLMVLPVVFYCAVPFYQGALRDLKN       190       200       210       220       230       240       250       260       270       280       290       300 m704.pepRRVGMDTPITVAIIMTFIAGVYSLATNAGQGMYFESIAMLLFFLLGGRFMEHIARRKAGD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a704RRVGMDTPITVAIIMTFIAGVYSLATNAGQGMYFESIAMLLFFLLGGRFMEHIARRKAGD       250       260       270       280       290       300       310       320       330       340       350       360 m704.pepAAERLVKLIPAFCHHMPDYPDTQETCEAAVVKLKAGDIVLVKPGETIPVDGTVLEGSSAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a704AAERLVKLIPAFCHHMPDYPDTQETCEAAVVKLKAGDIVLVKPGETIPVDGTVLEGSSAV       310       320       330       340       350       360       370       380       390       400       410       420 m704.pepNESMLTGESLPVAKMPSEKVTAGTLNTQSPLIIRTDRTGGGTRLSHIVRLLDRALAQKPR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a704NESMLTGESLPVAKMPSEKVTAGTLNTQSPLIIRTDRTGGGTRLSHIVRLLDRALAQKPR       370       380       390       400       410       420       430       440       450       460       470       480 m704.pepTAELAEQYASSFIFGELLLAVPVFIGWTLYADAHTALWITVALLVITCPCALSLATPTAL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a704TAELAEQYASSFIFGELLLAVPVFIGWTLYADAHTALWITVALLVITCPCALSLATPTAL       430       440       450       460       470       480       490       500       510       520       530       540 m704.pepAASTGTLAREGILIGGKQAIETLAQTTDIIFDRTGLLTQGKPAVRRISLLRGTDEAFVLA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a704AASTGTLAREGILIGGKQAIETLAQTTDIIFDRTGLLTQGKPAVRRISLLRGTDEAFVLA       490       500       510       520       530       540       550       560       570       580       590       600 m704.pepVAQALEQQSEHPLARAILNCRISDGSVPDIAIKQRLNRIGEGVGAQLTVNGETQVWALGR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a704VAQALEQQSEHPLARAILNCRISDGSVPDIAIKQRLNRIGEGVGAQLTVNGETQVWALGR       550       560       570       580       590       600       610       620       630       640       650       660 m704.pepASYVAEISGKEPQTEGGGSAVYLGSQSGFQAVFYLTDPLKDSAAEAVRQLAGKNLTLHIL||||||||||||||||||||||||||||||||||| |||||||||||||||||||||||| a704ASYVAEISGKEPQTEGGGSAVYLGSQSGFQAVFYLQDPLKDSAAEAVRQLAGKNLTLHIL       610       620       630       640       650       660       670       680       690       700       710       720 m704.pepSGDRETAVAETARALGVAHYRAQAMPEDKLEYVKALQKEGKKVLMIGDGINDAPVLAQAD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a704SGDRETAVAETARALGVAHYRAQAMPEDKLEYVKALQKEGKKVLMIGDGINDAPVLAQAD       670       680       690       700       710       720       730       740       750       760       770       780 m704.pepVSAAAAGGTDIARDGADIVLLNEDLRTVAHLLDQARRTRHIIRQNLIWAGAYNIIAVPLA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a704VSAAAAGGTDIARDGADIVLLNEDLRTVAHLLDQARRTRHIIRQNLIWAGAYNIIAVPLA       730       740       750       760       770       780       790       800       810       820 m704.pepVLGYVQPWIAALGMSFSSLAVLGNALRLHKRGKMQSEKMPSEQX|||||||||||||||||||||||||||||||||||||||||||| a704VLGYVQPWIAALGMSFSSLAVLGNALRLHKRGKMQSEKMPSEQX       790       800       810       820The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2357>:

g705.seq 1 GTGTTCAATA ATTTCCttgC CTCTCTGCCG TTTATGACGG AAACACGCGC 51TGATATGCTC ATCAGCGCGT TTTGGCCCAT GGTTAAAGCC GGCTTTACAG 101 TGTCTTtgcCTTTGGCGATC GCTTCTTTCG TTATCGGCAT GATTATTGCC 151 GTAGCCGTTG CTTTGGTAAGAATCATGCCT TCCGGCGGTA TTTTCCAAAA 201 ATGCTTGTTG AAGCTGGTGG AATTTTATATTTCCGTCGTT CGCGGTACGC 251 CGCTGTTGGT TCAGCTTGTG ATTGTGTTTT ACGGGCTGCCGTCCGTCGGC 301 ATCTATATCA ATCCGATTCC CGCCGCCATC ATCGGCTTTT CGCTCAATGT351 CGGCGCATAC GCTTCCGAAA CCATACGCGC GGCGATTTTG TCCGTGCCGA 401AAGGGCAGTG GGAAGCAGGT TTCTCCATCG GTATGACCTA TATGCAGACG 451 TTCCGCCGCATCGTCGCACC GCAGGCATTC CGCGTCGCCG TTCCGCCGTT 501 GAGCAACGAG TTTATCGGCTTGTTCAAAAA CACCTCGCTT GCCGCCGTGG 551 TAACGGTAAC GGAGCTTTTC CGTGTCGCACAGGAAACGGC AAACCGCACT 601 TATGACTTTT TGCCTGTCTA TATCGAAGCT GCATTGGTTTATTGGTGTTT 651 CTGTAAAGTG CTGTTTTTGA TTCAGGCGCG TTTGGAAAAA CGTTTCGACC701 GTTATGTCGC CAAATAAThis corresponds to the amino acid sequence <SEQ ID 2358; ORF 705>:

g705.pep 1 VFNNFLASLP FMTETRADML ISAFWPMVKA GFTVSLPLAI ASFVIGMIIA 51VAVALVRIMP SGGIFQKCLL KLVEFYISVV RGTPLLVQLV IVFYGLPSVG 101 IYINPIPAAIIGFSLNVGAY ASETIRAAIL SVPKGQWEAG FSIGMTYMQT 151 FRRIVAPQAF RVAVPPLSNEFIGLFKNTSL AAVVTVTELF RVAQETANRT 201 YDFLPVYIEA ALVYWCFCKV LFLIQARLEKRFDRYVAK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2359>:

m705.seq 1 GTGTTCAATA ATTTCCTTGC TTCGCTGCCG TTTATGACGG AAACACGCGC 51CGATATGATT GTCAGCGCGT TTTTGCCTAT GGTCAAAGCC GGCTTCGCGG 101 TCTCTCTGCCTTTGGCGGCA GCTTCTTTCG TTATCGGTAT GATGATTGCG 151 GTAGCCGTGG CTTTGGTGCGGATTATGCCC GCCGGCGGCA TCGTGCGGAA 201 AATCCTGCTG AAATTGGTGG AATTTTATATTTCCGTCATT CGCGGTACGC 251 CGCTGTTGGT TCAGCTTGTG ATTGTGTTTT ACGGGCTGCCTTCCGTCGGC 301 ATCTATATCG ACCCGATTCC TGCCGCCATC ATCGGCTTTT CGCTCAATGT351 CGGCGCATAC GCTTCCGAAA CCATACGCGC GGCAATTTTG TCCGTACCTA 401AAGGCCAATG GGAAGCAGGT TTCTCCATCG GCATGACCTA TATGCAGACG 451 TTCCGCCGCATTGTCGCGCC GCAGGCATTC CGCGTTGCCG TGCCGCCTTT 501 GAGCAACGAG TTTATCGGTTTGTTTAAAAA CACCTCGCTC GCGGCAGTCG 551 TGACGGTAAC GGAATTATTC CGCGTCGCGCAGGAAACGGC AAACCGCACT 601 TATGACTTTT TGCCCGTCTA TATCGAAGCC GCTTTGGTTTACTGGTGTTT 651 TTGTAAAGTG CTGTTCCTGA TTCAGGCGCG TTTGGAAAAA CGTTTCGACC701 GCTACGTCGC CAAATAAThis corresponds to the amino acid sequence <SEQ ID 2360; ORF 705>:

m705.pep 1 VFNNFLASLP FMTETRADMI VSAFLPMVKA GFAVSLPLAA ASFVIGMMIA 51VAVALVRIMP AGGIVRKILL KLVEFYISVI RGTPLLVQLV IVFYGLPSVG 101 IYIDPIPAAIIGFSLNVGAY ASETIRAAIL SVPKGQWEAG FSIGMTYMQT 151 FRRIVAPQAF RVAVPPLSNEFIGLFKNTSL AAVVTVTELF RVAQETANRT 201 YDFLPVYIEA ALVYWCFCKV LFLIQARLEKRFDRYVAK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 705 shows 95.0% identity over a 238 aa overlap with a predicted ORF(ORF 705) from N. gonorrhoeae:

m705/g705 95.0% identity in 238 aa overlap        10        20        30        40        50        60 m705.pepVFNNFLASLPFMTETRADMIVSAFLPMVKAGFAVSLPLAAASFVIGMMIAVAVALVRIMP|||||||||||||||||||::||| |||||||:|||||| |||||||:|||||||||||| g705VFNNFLASLPFMTETRADMLISAFWPMVKAGFTVSLPLAIASFVIGMIIAVAVALVRIMP        10        20        30        40        50        60        70        80        90       100       110       120 m705.pepAGGIVRKILLKLVEFYISVIRGTPLLVQLVIVFYGLPSVGIYIDPIPAAIIGFSLNVGAY:||| :| |||||||||||:|||||||||||||||||||||||:|||||||||||||||| g705SGGIFQKCLLKLVEFYISVVRGTPLLVQLVIVFYGLPSVGIYINPIPAAIIGFSLNVGAY        70        80        90       100       110       120       130       140       150       160       170       180 m705.pepASETIRAAILSVPKGQWEAGFSIGMTYMQTFRRIVAPQAFRVAVPPLSNEFIGLFKNTSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g705ASETIRAAILSVPKGQWEAGFSIGMTYMQTFRRIVAPQAFRVAVPPLSNEFIGLFKNTSL       130       140       150       160       170       180       190       200       210       220       230      239 m705.pepAAVVTVTELFRVAQETANRTYDFLPVYIEAALVYWCFCKVLFLIQARLEKRFDRYVAKX||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g705AAVVTVTELFRVAQETANRTYDFLPVYIEAALVYWCFCKVLFLIQARLEKRFDRYVAKX       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2361>:

a705.seq 1 GTGTTCAATA ATTTCCTTGC TTCGCTGCCG TTTATGACGG AAACACGCGC 51CGATATGATT GTCAGCGCGT TTTTGCCTAT GGTCAAAGCC GGCTTCGCGG 101 TCTCTCTGCCTTTGGCGGCA GCTTCTTTCG TTATCGGTAT GATGATTGCG 151 GTAGCCGTGG CTTTGGTGCGGATTATGCCC GCCGGCGGCA TCGTGCGGAA 201 AATCCTGCTG AAATTGGTGG AATTTTATATTTCCGTCATT CGCGGTACGC 251 CGCTGTTGGT TCAGCTTGTG ATTGTGTTTT ACGGGCTGCCTTCCGTCGGC 301 ATCTATATCG ACCCGATTCC TGCCGCCATC ATCGGCTTTT CGCTCAATGT351 CGGCGCATAT GCTTCCGAAA CCATACGCGC GGCAATTTTG TCCGTACCGA 401AAGGCCAATG GGAAGCAGGT TTCTCCATCG GCATGACCTA TATGCAGACG 451 TTCCGCCGCATCGTCGCGCC GCAGGCATTT CGCGTTGCCG TGCCGCCTTT 501 GAGCAACGAG TTTATCGGTTTGTTTAAAAA CACCTCGCTC GCGGCAGTCG 551 TGACGGTAAC GGAATTATTC CGCGTCGCGCAGGAAACGGC AAACCGCACT 601 TATGACTTTT TGCCCGTCTA TATCGAAGCC GCTTTGGTTTACTGGTGTTT 651 TTGTAAAGTG CTGTTCCTGA TTCAGGCGCG TTTGGAAAAA CGTTTCGACC701 GCTACGTCGC CAAATAAThis corresponds to the amino acid sequence <SEQ ID 2362; ORF 705.a>:

a705.pep 1 VFNNFLASLP FMTETRADMI VSAFLPMVKA GFAVSLPLAA ASFVIGMMIA 51VAVALVRIMP AGGIVRKILL KLVEFYISVI RGTPLLVQLV IVFYGLPSVG 101 IYIDPIPAAIIGFSLNVGAY ASETIRAAIL SVPKGQWEAG FSIGMTYMQT 151 FRRIVAPQAF RVAVPPLSNEFIGLFKNTSL AAVVTVTELF RVAQETANRT 201 YDFLPVYIEA ALVYWCFCKV LFLIQARLEKRFDRYVAK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N meningitidisORF 705 shows 100.0% identity over a 238 aa overlap with a predicted ORF(ORF 705) from N. meningitidis:

a705/m705 100.0% identity in 238 aa overlap        10        20        30        40        50        60 a705.pepVFNNFLASLPFMTETRADMIVSAFLPMVKAGFAVSLPLAAASFVIGMMIAVAVALVRIMP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m705VFNNFLASLPFMTETRADMIVSAFLPMVKAGFAVSLPLAAASFVIGMMIAVAVALVRIMP        10        20        30        40        50        60        70        80        90       100       110       120 a705.pepAGGIVRKILLKLVEFYISVIRGTPLLVQLVIVFYGLPSVGIYIDPIPAAIIGFSLNVGAY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m705AGGIVRKILLKLVEFYISVIRGTPLLVQLVIVFYGLPSVGIYIDPIPAAIIGFSLNVGAY        70        80        90       100       110       120       130       140       150       160       170       180 a705.pepASETIRAAILSVPKGQWEAGFSIGMTYMQTFRRIVAPQAFRVAVPPLSNEFIGLFKNTSL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m705ASETIRAAILSVPKGQWEAGFSIGMTYMQTFRRIVAPQAFRVAVPPLSNEFIGLFKNTSL       130       140       150       160       170       180       190       200       210       220       230      239 a705.pepAAVVTVTELFRVAQETANRTYDFLPVYIEAALVYWCFCKVLFLIQARLEKRFDRYVAKX||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m705AAVVTVTELFRVAQETANRTYDFLPVYIEAALVYWCFCKVLFLIQARLEKRFDRYVAKX       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2363>:

g706.seq 1 ATGAACTCCT CGCAACGCAA ACGCCTTTCC GgccGCTGGC TCAACTCCTA 51CGAACGCTac cGCCaccGCC GCCTCATACA TGCCGTGCGG CTCGGCggaa 101 ccgtCCTGTTCGCCACCGCA CTCGCCCGgc tACTCCACCT CCAacacggc 151 gAATGGATAG GGAtgaCCGTCTTCGTCGTC CTCGGCATGC TCCAGTTCCA 201 AGGCgcgatt tActccaacg cggtgGAacgtaTGctcggt acggtcatcg 251 ggctgGGCGC GGGTTTGGgc gTTTTATGGC TGAACCAGCATTAtttccac 301 ggcaacCTcc tcttctacct gaccatcggc acggcaagcg cactggccgg351 ctGGGCGGCG GTCGGCAAAA acggctacgt ccctatgctg GCGGGGctgA 401CGATGTGCAT gctcatcggc gACAACGGCA GCGAATGGCT CGACAGCGGC 451 CTGATGCGCGCGATGAACGT CCTCATCGGC GCCGCCATCG CCATTGCCGC 501 CGCCAAACTG CTGCCGCTGAAATCCACACT GATGTGGCGT TTCATGCTTG 551 CCGACAACCT GGCCGACTGC AGCAAAATGATTGCCGAAAT CAGCAACGGC 601 AGGCGTATGA CGCGCGAACG TTTGGAGCAG AATATGGTCAAAATGCGCCA 651 AATCAACGCA CGCATGGTCA AAAGCCGCAG CCACCTCGCC GCCACATCGG701 GCGAAAGCCG CATCAGCCCC TCCATGATGG AAGCCATGCA GCACGCCCAC 751CGCAAAATCG TCAACACCAC CGAGCTGCTC CTGACCACCG CCGCCAAGCT 801 GCAATCTCCCAAACTCAACG GCAGCGAAAT CCGGCTGCTC GACCGCCACT 851 TCACACTGCT CCAAACCGACCTGCAACAAA CCGCCGCCCT CATCAACGGC 901 AGACACGCCC GCCGCATCCG CATCGACACCGCCATCAACC CCGAACTGGA 951 AGCCCTCGCC GAACACCTCC ACTACCAATG GCAGGGCTTCCTCTGGCTCA 1001 GCACCAATAT GCGTCAGGAA ATTTCCGCCC TCGTCATCCT GCTGCAACGC1051 ACCCGCCGCA AATGGCTGGA TGCCCACGAA CGCCAACACC TGCGCCAAAG 1101CCTGCTTGAA ACACGGGAAC ACGGCTGAThis corresponds to the amino acid sequence <SEQ ID 2364; ORF 706.ng>:

g706.pep 1 MNSSQRKRLS GRWLNSYERY RHRRLIHAVR LGGTVLFATA LARLLHLQHG 51EWIGMTVFVV LGMLQFQGAI YSNAVERMLG TVIGLGAGLG VLWLNQHYFH 101 GNLLFYLTIGTASALAGWAA VGKNGYVPML AGLTMCMLIG DNGSEWLDSG 151LMRAMNVLIG AAIAIAAAKL LPLKSTLMWR FMLADNLADC SKMIAEISNG 201 RRMTRERLEQNMVKMRQINA RMVKSRSHLA ATSGESRISP SMMEAMQHAH 251 RKIVNTTELL LTTAAKLQSPKLNGSEIRLL DRHFTLLQTD LQQTAALING 301 RHARRIRIDT AINPELEALA EHLHYQWQGFLWLSTNMRQE ISALVILLQR 351 TRRKWLDAHE RQHLRQSLLE TREHG*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2365>:

m706.seq 1 ATGAACACCT CGCAACGCAA CCGCCTCGTC AGCCGCTGGC TCAACTCCTA 51CGAACGCTAC CGCTACCGCC GCCTCATCCA CGCCGTCCGG CTCGGCGGGG 101 CCGTCCTGTTCGCCACCGCC TCCGCCCGGC TGCTCCACCT CCAACACGGC 151 GAGTGGATAG GGATGACCGTCTTCGTCGTC CTCGGCATGC TCCAGTTTCA 201 AGGGGCGATT TACTCCAAGG CGGTGGAACGTATGCTCGGC ACGGTCATCG 251 GGCTGGGCGC GGGTTTGGGC GTTTTATGGC TGAACCAGCATTATTTCCAC 301 GGCAACCTCC TCTTCTACCT CACCGTCGGC ACGGCAAGCG CACTGGCCGG351 CTGGGCGGCG GTCGGCAAAA ACGGCTACGT CCCTATGCTG GCAGGGCTGA 401CGATGTGTAT GCTCATCGGC GACAACGGCA GCGAATGGCT CGACAGCGGA 451 CTCATGCGCGCCATGAACGT CCTCATCGGC GCGGCCATCG CCATCGCCGC 501 CGCCAAACTG CTGCCGCTGAAATCCACACT GATGTGGCGT TTCATGCTTG 551 CCGACAACCT GGCCGACTGC AGCAAAATGATTGCCGAAAT CAGCAACGGC 601 AGGCGCATGA CCCGCGAACG CCTCGAGGAG AACATGGCGAAAATGCGCCA 651 AATCAACGCA CGCATGGTCA AAAGCCGCAG CCATCTCGCC GCCACATCGG701 GCGAAAGCCG CATCAGCCCC GCCATGATGG AAGCCATGCA GCACGCCCAC 751CGTAAAATCG TCAACACCAC CGAGCTGCTC CTGACCACCG CCGCCAAGCT 801 GCAATCTCCCAAACTCAACG GCAGCGAAAT CCGGCTGCTT GACCGCCACT 851 TCACACTGCT CCAAACCGACCTGCAACAAA CCGTCGCCCT TATCAACGGC 901 AGACACGCCC GCCGCATCCG CATCGACACCGCCATCAACC CCGAACTGGA 951 AGCCCTCGCC GAACACCTCC ACTACCAATG GCAGGGCTTCCTCTGGCTCA 1001 GCACCAATAT GCGTCAGGAA ATTTCCGCCC TCGTCATCCT GCTGCAACGC1051 ACCCGCCGCA AATGGCTGGA TGCCCACGAA CGCCAACACC TGCGCCAAAG 1101CCTGCTTGAA ACACGGGAAC ACGGCTGAThis corresponds to the amino acid sequence <SEQ ID 2366; ORF 706>:

m706.pep 1 MNTSQRNRLV SRWLNSYERY RYRRLIHAVR LGGAVLFATA SARLLHLQHG 51EWIGMTVFVV LGMLQFQGAI YSKAVERMLG TVIGLGAGLG VLWLNQHYFH 101 GNLLFYLTVGTASALAGWAA VGKNGYVPML AGLTMCMLIG DNGSEWLDSG 151LMRAMNVLIG AAIAIAAAKL LPLKSTLMWR FMLADNLADC SKMIAEISNG 201 RRMTRERLEENMAKMRQINA RMVKSRSHLA ATSGESRISP AMMEAMQHAH 251 RKIVNTTELL LTTAAKLQSPKLNGSEIRLL DRHFTLLQTD LQQTVALING 301 RHARRIRIDT AINPELEALA EHLHYQWQGFLWLSTNMRQE ISALVILLQR 351 TRRKWLDAHE RQHLRQSLLE TREHG* m706/g706 96.5%identity in 375 aa overlap        10        20        30        40        50        60 m706.pepMNTSQRNRLVSRWLNSYERYRYRRLIHAVRLGGAVLFATASARLLHLQHGEWIGMTVFVV||:|||:|| :||||||||||:|||||||||||:|||||| ||||||||||||||||||| g706MNSSQRKRLSGRWLNSYERYRHRRLIHAVRLGGTVLFATALARLLHLQHGEWIGMTVFVV        10        20        30        40        50        60        70        80        90       100       110       120 m706.pepLGMLQFQGAIYSKAVERMLGTVIGLGAGLGVLWLNQHYFHGNLLFYLTVGLASALAGWAA||||||||||||:|||||||||||||||||||||||||||||||||||:||||||||||| g706LGMLQFQGAIYSNAVERMLGTVIGLGAGLGVLWLNQHYFHGNLLFYLTIGTASALAGWAA        70        80        90       100       110       120       130       140       150       160       170       180 m706.pepVGKNGYVPMLAGLTMCMLIGDNGSEWLDSGLMRAMNVLIGAAIAIAAAKLLPLKSTLMWR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g706VGKNGYVPMLAGLTMCMLIGDNGSEWLDSGLMRAMNVLIGAAIAIAAAKLLPLKSTLMWR       130       140       150       160       170       180       190       200       210       220       230       240 m706.pepFMLADNLADCSKMIAEISNGRRMTRERLEENMAKMRQINARMVKSRSHLAATSGESRISP|||||||||||||||||||||||||||||:||:||||||||||||||||||||||||||| g706FMLADNLADCSKMIAEISNGRRMTRERLEQNMVKMRQINARMVKSRSHLAATSGESRISP       190       200       210       220       230       240       250       260       270       280       290       300 m706.pepAMMEAMQHAHRKIVNTTELLLTTAAKLQSPKLNGSEIRLLDRHFTLLQTDLQQTVALING:|||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| g706SMMEAMQHAHRKIVNTTELLLTTAAKLQSPKLNGSEIRLLDRHFTLLQTDLQQTAALING       250       260       270       280       290       300       310       320       330       340       350       360 m706.pepRHARRIRIDTAINPELEALAEHLHYQWQGFLWLSTNMRQEISALVILLQRTRRKWLDAHE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g706RHARRIRIDTAINPELEALAEHLHYQWQGFLWLSTNMRQEISALVILLQRTRRKWLDAHE       310       320       330       340       350       360        370m706.pep RQHLRQSLLETREHGX |||||||||||||||| g706 RQHLRQSLLETREHGX       370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2367>:

a706.seq 1 ATGAACACCT CGCAACGCAA CCGCCTCGTC AGCCGCTGGC TCAACTCCTA 51CGAACGCTAC CGCTACCGCC GCCTCATCCA CGCCGTCCGG CTCGGCGGGG 101 CCGTCCTGTTCGCCACCGCC TCCGCCCGGC TGCTCCACCT CCAACACGGC 151 GAGTGGATAG GGATGACCGTCTTCGTCGTC CTCGGCATGC TCCAGTTTCA 201 AGGGGCGATT TACTCCAAGG CGGTGGAACGTATGCTCGGC ACGGTCATCG 251 GGCTGGGCGC GGGTTTGGGC GTTTTATGGC TGAACCAGCATTATTTCCAC 301 GGCAACCTCC TCTTCTACCT CACCGTCGGC ACGGCAAGCG CACTGGCCGG351 CTGGGCGGCG GTCGGCAAAA ACGGCTACGT CCCTATGCTG GCGGGGCTGA 401CGATGTGCAT GCTCATCGGC GACAACGGCA GCGAATGGTT CGACAGCGGC 451 CTGATGCGCGCGATGAACGT CCTCATCGGC GCGGCCATCG CCATCGCCGC 501 CGCCAAACTG CTGCCGCTGAAATCCACACT GATGTGGCGT TTCATGCTTG 551 CCGACAACCT GACCGACTGC AGCAAAATGATTGCCGAAAT CAGCAACGGC 601 AGGCGCATGA CCCGCGAACG CCTCGAAGAG AACATGGCGAAAATGCGCCA 651 AATCAACGCA CGCATGGTCA AAAGCCGCAG CCACCTCGCC GCCACATCGG701 GCGAAAGCCG CATCAGCCCC GCCATGATGG AAGCCATGCA GCACGCCCAC 751CGTAAAATTG TCAACACCAC CGAGCTGCTC CTGACCACCG CCGCCAAGCT 801 GCAATCTCCCAAACTCAACG GCAGCGAAAT CCGGCTGCTT GACCGCCACT 851 TCACACTGCT CCAAACCGACCTGCAACAAA CCGTCGCCCT TATCAACGGC 901 AGACACGCCC GCCGCATCCG CATCGACACCGCCATCAACC CCGAACTGGA 951 AGCCCTCGCC GAACACCTCC ACTACCAATG GCAGGGCTTCCTCTGGCTCA 1001 GCACCAATAT GCGTCAGGAA ATTTCCGCCC TCGTCATCCT GCTGCAACGC1051 ACCCGCCGCA AATGGCTGGA TGCCCACGAA CGCCAACACC TGCGCCAAAG 1101CCTGCTTGAA ACACGGGAAC ACAGTTGAThis corresponds to the amino acid sequence <SEQ ID 2368; ORF 706.a>:

a706.pep 1 MNTSQRNRLV SRWLNSYERY RYRRLIHAVR LGGAVLFATA SARLLHLQHG 51EWIGMTVFVV LGMLQFQGAI YSKAVERMLG TVIGLGAGLG VLWLNQHYFH 101 GNLLFYLTVGTASALAGWAA VGKNGYVPML AGLTMCMLIG DNGSEWFDSG 151LMRAMNVLIG AAIAIAAAKL LPLKSTLMWR FMLADNLTDC SKMIAEISNG 201 RRMTRERLEENMAKMRQINA RMVKSRSHLA ATSGESRISP AMMEAMQHAH 251 RKIVNTTELL LTTAAKLQSPKLNGSEIRLL DRHFTLLQTD LQQTVALING 301 RHARRIRIDT AINPELEALA EHLHYQWQGFLWLSTNMRQE ISALVILLQR 351 TRRKWLDAHE RQHLRQSLLE TREHS* a706/m706 99.5%identity in 374 aa overlap        10        20        30        40        50        60 a706.pepMNTSQRNRLVSRWLNSYERYRYRRLIHAVRLGGAVLFATASARLLHLQHGEWIGMTVFVV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m706MNTSQRNRLVSRWLNSYERYRYRRLIHAVRLGGAVLFATASARLLHLQHGEWIGMTVFVV        10        20        30        40        50        60        70        80        90       100       110       120 a706.pepLGMLQFQGAIYSKAVERMLGTVIGLGAGLGVLWLNQHYFHGNLLFYLTVGTASALAGWAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m706LGMLQFQGAIYSKAVERMLGTVIGLGAGLGVLWLNQHYFHGNLLFYLTVGTASALAGWAA        70        80        90       100       110       120       130       140       150       160       170       180 a706.pepVGKNGYVPMLAGLTMCMLIGDNGSEWFDSGLMRAMNVLIGAAIAIAAAKLLPLKSTLMWR||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| m706VGKNGYVPMLAGLTMCMLIGDNGSEWLDSGLMRAMNVLIGAAIAIAAAKLLPLKSTLMWR       130       140       150       160       170       180       190       200       210       220       230       240 a706.pepFMLADNLTDCSKMIAEISNGRRMTRERLEENMAKMRQINARMVKSRSHLAATSGESRISP|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||| m706FMLADNLADCSKMIAEISNGRRMTRERLEENMAKMRQINARMVKSRSHLAATSGESRISP       190       200       210       220       230       240       250       260       270       280       290       300 a706.pepAMMEAMQHAHRKIVNTTELLLTTAAKLQSPKLNGSEIRLLDRHFTLLQTDLQQTVALING|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||| m706AMMEAMQHAHRKIVNTTELLLTTAAKLQSPKLNGSEIRLLDRHFTLLQTDLQQTVALING       250       260       270       280       290       300       310       320       330       340       350       360 a706.pepRHARRIRIDTAINPELEALAEHLHYQWQGFLWLSTNMRQEISALVILLQRTRRKWLDAHE|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||| m706RHARRIRIDTAINPELEALAEHLHYQWQGFLWLSTNMRQEISALVILLQRTRRKWLDAHE       310       320       330       340       350       360        370a706.pep RQHLRQSLLETREHSX ||||||||||||||: m706 RQHLRQSLLETREHGX       370

g707.seq not found

g707.pep not found

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2369>:

m707.seq 1 ATGGAAATTA TTAACGATGC AGAACTTATC CGTTCCATGC AGCGTCAGCA 51GCACATAGAT GCTGAATTGT TAACTGATGC AAATGTCCGT TTCGAGCAAC 101 CATTGGAGAAGAACAATTAT GTCCTGAGTG AAGATGAAAC ACCGTGTACT 151 CGGGTAAATT ACATTAGTTTAGATGATAAG ACGGTGCGCA AATTTTCTTT 201 TCTTCCTTCT GTGCTCATGA AAGAAACAGCTTTTAAAACT GGGATGTGTT 251 TAGGTTCCAA TAATTTGAGC AGGCTACAAA AAGCCGCGCAACAGATACTG 301 ATCGTGCGTG GCTACCTCAC TTCCCAAGCT ATTATCCAAC CACAGAATAT351 GGATTCGGGA ATTCTGAAAT TACGGGTATC AGCAGGCGAA ATAGGGGATA 401TCCGCTATGA AGAAAAACGG GATGGGAAGT CTGCCGAGGG CAGTATTAGT 451 GCATTCAATAACAAATTTCC CTTATATAGG AACAAAATTC TCAATCTTCG 501 CGATGTAGAG CAGGGCTTGGAAAACCTGCG TCGTTTGCCG AGTGTTAAAA 551 CAGATATTCA GATTATACCG TCCGAAGAAGAAGGCAAAAG CGATTTACAG 601 ATCAAATGGC AGCAGAATAA ACCCATACGG TTCAGTATCGGTATAGATGA 651 TGCGGGCGGC AAAACGACCG GCAAATATCA AGGAAATGTC GCTTTATCGT701 TCGATAACCC TTTGGGCTTA AGCGATTTGT TTTATGTTTC ATATGGACGC 751GGTTTGGCGC ACAAAACGGA CTTGACTGAT GCCACCGGTA CGGAAACTGA 801 AAGCGGATCCAGAAGTTACA GCGTGCATTA TTCGGTGCCC GTAAAAAAAT 851 GGCTGTTTTC TTTTAATCACAATGGACATC GTTACCACGA AGCAACCGAA 901 GGCTATTCCG TCAATTACGA TTACAACGGCAAACAATATC AGAGCAGCCT 951 GGCCGCCGAG CGCATGCTTT GGCGTAACAG ACTTCATAAAACTTCAGTCG 1001 GAATGAAATT ATGGACACGC CAAACCTATA AATACATCGA CGATGCCGAA1051 ATCGAAGTAC AACGCCGCCG CTCTGCAGGC TGGGAAGCCG AATTGCGCCA 1101CCGTGCTTAC CTCAACCGTT GGCAGCTTGA CGGCAAGTTG TCTTACAAAC 1151 GCGGGACCGGCATGCGCCAA AGTATGCCTG CACCGGAAGA AAACGGCGGC 1201 GATATTCTTC CAGGTACATCTCGTATGAAA ATCATTACTG CCAGTTTGGA 1251 CGCAGCCGCC CCATTTATTT TAGGCAAACAGCAGTTTTTC TACGCAACCG 1301 CCATTCAAGC TCAATGGAAC AAAACGCCGT TGGTTGCCCAAGATAAATTG 1351 TCAATCGGCA GCCGCTACAC CGTTCGCGGA TTTGATGGGG AGCAGAGTCT1401 TTTCGGAGAG CGAGGTTTCT ACTGGCAGAA TACTTTAACT TGGTATTTTC 1451ATCCGAACCA TCAGTTCTAT CTCGGTGCGG ACTATGGCCG CGTATCTGGC 1501 GAAAGTGCACAATATGTATC GGGCAAGCAG CTGATGGGTG CAGTGGTCGG 1551 CTTCAGAGGA GGGCATAAAGTAGGCGGTAT GTTTGCTTAT GATCTGTTTG 1601 CCGGCAAGCC GCTTCATAAA CCCAAAGGCTTTCAGACGAC CAACACCGTT 1651 TACGGCTTCA ACTTGAATTA CAGTTTCTAAThis corresponds to the amino acid sequence <SEQ ID 2370; ORF 707>:

m707.pep 1 MEIINDAELI RSMQRQQHID AELLTDANVR FEQPLEKNNY VLSEDETPCT 51RVNYISLDDK TVRKFSFLPS VLMKETAFKT GMCLGSNNLS RLQKAAQQIL 101 IVRGYLTSQAIIQPQNMDSG ILKLRVSAGE IGDIRYEEKR DGKSAEGSIS 151 AFNNKFPLYR NKILNLRDVEQGLENLRRLP SVKTDIQIIP SEEEGKSDLQ 201 IKWQQNKPIR FSIGIDDAGG KTTGKYQGNVALSFDNPLGL SDLFYVSYGR 251 GLAHKTDLTD ATGTETESGS RSYSVHYSVP VKKWLFSFNHNGHRYHEATE 301 GYSVNYDYNG KQYQSSLAAE RMLWRNRLHK TSVGMKLWTR QTYKYIDDAE351 IEVQRRRSAG WEAELRHRAY LNRWQLDGKL SYKRGTGMRQ SMPAPEENGG 401DILPGTSRMK IITASLDAAA PFILGKQQFF YATAIQAQWN KTPLVAQDKL 451 SIGSRYTVRGFDGEQSLFGE RGFYWQNTLT WYFHPNHQFY LGADYGRVSG 501 ESAQYVSGKQ LMGAVVGFRGGHKVGGMFAY DLFAGKPLHK PKGFQTTNTV 551 YGFNLNYSF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2371>:

a707.seq 1 NTGAAAGAAA CAGCTTTTAA AACTGGGATG TGTTTAGGTT CCAATAATTT 51GAGCAGGCTA CAAAAAGCCG CGCAACAGAT ACTGATTGTG CGTGGCTACC 101 TCACTTCCCAAGCTATTATC CAACCACAGA ATATGGATTC GGGAATTCTG 151 AAATTACGGG TATCAGCAGGCGAAATAGGN GATATCCGCT ATGAAGAAAA 201 ACGGGATGNG AAGTCTGCCG AGGGCAGTATTAGTGCATTC AATAACAAAN 251 TTCCCTTATA TAGGAACAAA ATTCTCAATC TTCGCGATGTAGAGCAGGGC 301 TTGGAAAACC TGCGTCGTTT GCCGAGTGTT AAAACAGATA TTCAGATTAT351 ACCGTCCGAA GAAGAAGGCA AAAGCGATTT ACAGATCAAA TGGCAGCAGA 401ATAAACCCAT ACGGTTCAGT ATCGGTATAG ATGATGCGGG CGGCAAAACG 451 ACCGGCAAATATCAAGGAAA TGTCGCTTTA TCGTNCGATA ACCCTTTGGG 501 NTTAAGCGAT TNGTTTTATGTTTCATATGG ACGCGGTTTG GTGCACAAAA 551 CGGACTTGAC TGNTGCCACC GGTACGGAAACTGAAAGCGG ATCCAGAAGT 601 TACAGCGTGC ATTATTCGGT GNNCGTAAAA AAATGGCTGTTTTCTTTTAA 651 TCACAATGGA CATCGTTACC ACGAAGCAAC CGAAGGCTAT TCCGTCAATT701 ACGATTACAA CGGCAAACAA TATCAGAGCA GCCTGGCCGC CGAGCGCATG 751CTTTGGNNNN NNAGNTTTCN TNAAACTTCA GTCNGAATGA AATTATGGAC 801 ACGCCAAACCTATAAATACA TCGACGATGC CGAAATCGAA GTGCAACGCC 851 GCCGCTCTGC AGGCTGGGAAGCCGAATTGC GCCACCGTGC TTACCTCNAC 901 CGTTGGCAGC TTGACGGCAA GTTGTCTTACAAACGCGGGA CCGGCATGCG 951 CCAAAGTATG CCCGCACCTG AAGAAAACGG CGGCGGTACTATTCCAGNCA 1001 NATCCCGTAT GAAAATCATA ACCGCCGGAT TGGATGCAGC GGCCCCGTNT1051 ATGTTGGGCA AACAGCAGTT TTTCTACGCA ACCGCCATTC AAGCTCAATG 1101GAACAAAACG CCTTTGGTTG CCCAAGACAA GTTGTCTATC GGCAGCCGCT 1151 ACACCGTTCGCGGATTTGAT GGGGAGCAGA GTCTTTTCGG AGAGCGAGGT 1201 TTCTACTGGC AGAATACTTTAACTTGGTAT TTTCATCCGA ACCATCAGTT 1251 CTATCTCGGT GCGGACTATG GCCGCGTATCTGGCGAAAGT GCACAATATG 1301 TATCGGGCAA GCAGCTGATG GGTGCAGTGG TCGGCTTCAGAGGAGGGCAT 1351 AAAGTAGGCG GTATGTTTGC TTATGATCTG TTTGCCGGCA AGCCGCTTCA1401 TAAACCCAAA GGCTTTCAGA CGACCAACAC CGTTTACGGC TTCAACTTGA 1451ATTACAGTTT CTAAThis corresponds to the amino acid sequence <SEQ ID 2372; ORF 707.a>:

a707.pep 1 XKETAFKTGM CLGSNNLSRL QKAAQQILIV RGYLTSQAII QPQNMDSGIL 51KLRVSAGEIG DIRYEEKRDX KSAEGSISAF NNKXPLYRNK ILNLRDVEQG 101 LENLRRLPSVKTDIQIIPSE EEGKSDLQIK WQQNKPIRFS IGIDDAGGKT 151 TGKYQGNVAL SXDNPLGLSDXFYVSYGRGL VHKTDLTXAT GTETESGSRS 201 YSVHYSVXVK KWLFSFNHNG HRYHEATEGYSVNYDYNGKQ YQSSLAAERM 251 LWXXXFXXTS VXMKLWTRQT YKYIDDAEIE VQRRRSAGWEAELRHRAYLX 301 RWQLDGKLSY KRGTGMRQSM PAPEENGGGT IPXXSRMKII TAGLDAAAPX351 MLGKQQFFYA TAIQAQWNKT PLVAQDKLSI GSRYTVRGFD GEQSLFGERG 401FYWQNTLTWY FHPNHQFYLG ADYGRVSGES AQYVSGKQLM GAVVGFRGGH 451 KVGGMFAYDLFAGKPLHKPK GFQTTNTVYG FNLNYSF* a707/m707 95.3% identity in 486 aaoverlap                                      10        20        30a707.pep                              XKETAFKTGMCLGSNNLSRLQKAAQQILIVR                              |||||||||||||||||||||||||||||| m707EDETPCTRVNYISLDDKTVRKFSFLPSVLMKETAFKTGMCLGSNNLSRLQKAAQQILIVR     50        60        70        80        90       100       40        50        60        70        80        90 a707.pepGYLTSQAIIQPQNMDSGILKLRVSAGEIGDIRYEEKRDXKSAEGSISAFNNKXPLYRNKI|||||||||||||||||||||||||||||||||||||| ||||||||||||| ||||||| m707GYLTSQAIIQPQNMDSGILKLRVSAGEIGDIRYEEKRDGKSAEGSISAFNNKFPLYRNKI    110       120       130       140       150       160      100       110       120       130       140       150 a707.pepLNLRDVEQGLENLRRLPSVKTDIQIIPSEEEGKSDLQIKWQQNKPIRFSIGIDDAGGKTT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m707LNLRDVEQGLENLRRLPSVKTDIQIIPSEEEGKSDLQIKWQQNKPIRFSIGIDDAGGKTT    170       180       190       200       210       220      160       170       180       190       200       210 a707.pepGKYQGNVALSXDNPLGLSDXFYVSYGRGLVHKTDLTXATGTETESGSRSYSVHYSVXVKK|||||||||| |||||||| |||||||||:|||||| ||||||||||||||||||| ||| m707GKYQGNVALSFDNPLGLSDLFYVSYGRGLAHKTDLTDATGTETESGSRSYSVHYSVPVKK    230       240       250       260       270       280      220       230       240       250       260       270 a707.pepWLFSFNHNGHRYHEATEGYSVNYDYNGKQYQSSLAAERMLWXXXFXXTSVXMKLWTRQTY|||||||||||||||||||||||||||||||||||||||||   :  ||| ||||||||| m707WLFSFNHNGHRYHEATEGYSVNYDYNGKQYQSSLAAERMLWRNRLHKTSVGMKLWTRQTY    290       300       310       320       330       340      280       290       300       310       320       330 a707.pepKYIDDAEIEVQRRRSAGWEAELRHRAYLXRWQLDGKLSYKRGTGMRQSMPAPEENGGGTI|||||||||||||||||||||||||||| ||||||||||||||||||||||||||||  : m707KYIDDAEIEVQRRRSAGWEAELRHRAYLNRWQLDGKLSYKRGTGMRQSMPAPEENGGDIL    350       360       370       380       390       400      340       350       360       370       380       390 a707.pepPXXSRMKIITAGLDAAAPXMLGKQQFFYATAIQAQWNKTPLVAQDKLSIGSRYTVRGFDG| :||||||||:|||||| :|||||||||||||||||||||||||||||||||||||||| m707PGTSRMKIITASLDAAAPFILGKQQFFYATAIQAQWNKTPLVAQDKLSIGSRYTVRGFDG    410       420       430       440       450       460      400       410       420       430       440       450 a707.pepEQSLFGERGFYWQNTLTWYFHPNHQFYLGADYGRVSGESAQYVSGKQLMGAVVGFRGGHK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m707EQSLFGERGFYWQNTLTWYFHPNHQFYLGADYGRVSGESAQYVSGKQLMGAVVGFRGGHK    470       480       490       500       510       520      460       470       480 a707.pepVGGMFAYDLFAGKPLHKPKGFQTTNTVYGFNLNYSFX||||||||||||||||||||||||||||||||||||| m707VGGMFAYDLFAGKPLHKPKGFQTTNTVYGFNLNYSFX    530       540       550       560The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2373>:

g708.seq 1 ATGCCTTTTA AGCCATCCAA ACGAATCTCT TTATTACTTG TTCTTGCCTT 51GGGCGCGTGC AGCACTTCCT ACCGCCCCTC GCGGGCAGAA AAAGCCAATC 101 AGGTTTCCAATATCAAAACC CAGTTGGCGA TGGAATATAT GCGCGGTCAG 151 GACTACCGTC AGGCAACGGCAAGTATTGAA GATGCCTTGA AATCGAACCC 201 TAAAAACGAA CTTGCCTGGC TGGTCCGTGCCGAAATCTAT CAATACCTGA 251 AAGTTAACGA CAAGGCGCAG GAAAGTTTCC GGCAAGCCCTCTCCATCAAA 301 CCCGACAGTG CCGAAATCAA CAACAACTAC GGCTGGTTCC TGTGCGGCAG351 GCTCAACCGC CCTGCCGAAT CTATGGCATA TTTCGACAAA GCCCTGGCCG 401ACCCCACCTA CCCGACCCCT TATATTGCCA ACCTGAATAA AGGTATATGC 451 AGCGCAAAACAGGGGCAATT CGGATTGGCG GAAGCCTATT TGAAACGTTC 501 CCTCGCCGCC CAGCCGCAGTTCCCACCCGC ATTTAAAGAA CTGGCGCGCA 551 CCAAAATGCT GGCCGGGCAG TTGGGCGATGCCGATTACTA CTTTAAAAAA 601 TACCAAAGCA GGGTAGAAGT CCTTCAGGCC GATGATTTGCTGCTAGGCTG 651 GAAAATTGCC AAAGCCCTCG GCAACGTGCA GGCGGCATAC GAATATGAAG701 CACAATTGCA GGCAAATTTC CCCTACTCGG AAGAATTGCA AACCGTCCTC 751ACCGGTCAAT AAThis corresponds to the amino acid sequence <SEQ ID 2374; ORF 708.ng>:

g708.pep 1 MPFKPSKRIS LLLVLALGAC STSYRPSRAE KANQVSNIKT QLAMEYMRGQ 51DYRQATASIE DALKSNPKNE LAWLVRAEIY QYLKVNDKAQ ESFRQALSIK 101 PDSAEINNNYGWFLCGRLNR PAESMAYFDK ALADPTYPTP YIANLNKGIC 151 SAKQGQFGLA EAYLKRSLAAQPQFPPAFKE LARTKMLAGQ LGDADYYFKK 201 YQSRVEVLQA DDLLLGWKIA KALGNVQAAYEYEAQLQANF PYSEELQTVL 251 TGQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2375>:

m708.seq 1 ATGCCTTTTA AGCCATCCAA ACGAATCTCT TTATTACTCG TTCTTGCCTT 51GGGCGCGTGC AGCACTTCCT ACCGCCCCTC GCGGGCAGAA AAAGCCAATC 101 AGGTTTCCAATATCAAAACC CAGTTGGCAA TGGAATATAT GCGCGGTCAG 151 GACTACCGTC AGGCGACGGCAAGTATTGAA GACGCCCTGA AATCGGACCC 201 TAAAAACGAG CTTGCCTGGC TGGTCCGTGCCGAAATCTAT CAATACCTGA 251 AAGTTAACGA CAAGGCGCAG GAAAGTTTCC GGCAAGCCCTCTCCATCAAA 301 CCCGACAGTG CCGAAATCAA CAACAACTAC GGTTGGTTCC TATGCGGCAG351 GCTCAACCGC CCTGCCGAAT CTATGGCATA TTTCGACAAA GCTCTGGCCG 401ACCCCACCTA CCCGACCCCT TATATTGCCA ACCTGAATAA AGGCATATGC 451 AGCGCAAAACAGGGGCAATT CGGATTGGCG GAAGCCTATT TGAAACGTTC 501 CCTCGCCGCC CAGCCGCAGTTCCCACCCGC ATTTAAAGAA CTGGCGCGCA 551 CCAAAATGCT GGCCGGGCAG TTGGGCGATGCCGATTACTA CTTTAAAAAA 601 TACCAAAGCA GGGTAGAAGT CCTTCAGGCC GATGATTTGCTGCTAGGCTG 651 GAAAATTGCC AAAGCCCTCG GCAACGCACA GGCGGCATAC GAATATGAAG701 CACAATTGCA GGCGAATTTC CCCTACTCGG AAGAATTGCA AACCGTCCTC 751ACCGGTCAAT AAThis corresponds to the amino acid sequence <SEQ ID 2376; ORF 708>:

m708.pep 1 MPFKPSKRIS LLLVLALGAC STSYRPSRAE KANQVSNIKT QLAMEYMRGQ 51DYRQATASIE DALKSDPKNE LAWLVRAEIY QYLKVNDKAQ ESFRQALSIK 101 PDSAEINNNYGWFLCGRLNR PAESMAYFDK ALADPTYPTP YIANLNKGIC 151 SAKQGQFGLA EAYLKRSLAAQPQFPPAFKE LARTKMLAGQ LGDADYYFKK 201 YQSRVEVLQA DDLLLGWKIA KALGNAQAAYEYEAQLQANF PYSEELQTVL 251 TGQ* m708/g708 99.2% identity in 253 aaoverlap         10        20        30        40        50        60m708.pep MPFKPSKRISLLLVLALGACSTSYRPSRAEKANQVSNIKTQLAMEYMRGQDYRQATASIE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g708MPFKPSKRISLLLVLALGACSTSYRPSRAEKANQVSNIKTQLAMEYMRGQDYRQATASIE        10        20        30        40        50        60        70        80        90       100       110       120 m708.pepDALKSDPKNELAWLVRAEIYQYLKVNDKAQESFRQALSIKPDSAEINNNYGWFLCGRLNR|||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||| g708DALKSNPKNELAWLVRAEIYQYLKVNDKAQESFRQALSIKPDSAEINNNYGWFLCGRLNR        70        80        90       100       110       120       130       140       150       160       170       180 m708.pepPAESMAYFDKALADPTYPTPYIANLNKGICSAKQGQFGLAEAYLKRSLAAQPQFPPAFKE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g708PAESMAYFDKALADPTYPTPYIANLNKGICSAKQGQFGLAEAYLKRSLAAQPQFPPAFKE       130       140       150       160       170       180       190       200       210       220       230       240 m708.pepLARTKMLAGQLGDADYYFKKYQSRVEVLQADDLLLGWKIAKALGNAQAAYEYEAQLQANF|||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||| g708LARTKMLAGQLGDADYYFKKYQSRVEVLQADDLLLGWKIAKALGNVQAAYEYEAQLQANF       190       200       210       220       230       240        250m708.pep PYSEELQTVLTGQX |||||||||||||| g708 PYSEELQTVLTGQX        250The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2377>:

a708.seq 1 ATGCCTTTTA AGCCATCCAA ACGAATCTCT TTATTACTTG TCCTTGCCTT 51GGGCGCGTGC AGCACTTCCT ACCGCCCCTC GCGGGCAGAA AAAGCCAATC 101 AGGTTTCCAATATCAAAACC CAGTTGGCAA TGGAATATAT GCGCGGTCAG 151 GACTACCGTC AGGNGACGGCAAGTATTGAA GACGCCTTGA AATCAGACCC 201 TAAAAACGAG CTTGCCTGGC TGGTCCGTGCCGAAATCTAT CAATACCTGA 251 AAGTTAACGA CAAGGCGCAG GAAAGTTTCC GGCAAGNCCTCTCCATCAAA 301 CCCGACAGTG CCGAAATCAA CAACAACTAC NGCTGGTTCC TGTGCGGCAG351 GCTCAACCGC CCTGCCGAAT CTATGGCATA TTTCGACAAA GCCCTGGCCG 401ACCCCACNTA CCCGANCCCT TATATTGCCA ACCTGAATAA AGGCATATGC 451 AGCGCAAAACAGGGGCAATT CGGATTGGCG GAAGCCTATT TGAAACGTTC 501 CCTCGCCGCC CAGCCGCAGTTCCCACCCGC ATTTAAAGAA CTGGCGCGCA 551 CCAAAATGCT GGCCGGGCAG TTGGGCGATGCCGATTACTA CTTTAAAAAA 601 TACCAAAGCA GGGTAGAAGT CCTTCAGGCC GATGATTTGCTGCTAGGCTG 651 GAAAATTGCC AAAGCCCTCG GCAACGCACA GGCGGCATAC GAATATGAAG701 CACAATTGCA GGCGAATTTC CCCTACTCGG AAGAATTGCA AACCGTCCTC 751ATCGGTCAAT AAThis corresponds to the amino acid sequence <SEQ ID 2378; ORF 708.a>:

a708.pep 1 MPFKPSKRIS LLLVLALGAC STSYRPSRAE KANQVSNIKT QLAMEYMRGQ 51DYRQXTASIE DALKSDPKNE LAWLVRAEIY QYLKVNDKAQ ESFRQXLSIK 101 PDSAEINNNYXWFLCGRLNR PAESMAYFDK ALADPTYPXP YIANLNKGIC 151 SAKQGQFGLA EAYLKRSLAAQPQFPPAFKE LARTKMLAGQ LGDADYYFKK 201 YQSRVEVLQA DDLLLGWKIA KALGNAQAAYEYEAQLQANF PYSEELQTVL 251 IGQ* a708/m708 98.0% identity in 253 aaoverlap         10        20        30        40        50        60a708.pep MPFKPSKRISLLLVLALGACSTSYRPSRAEKANQVSNIKTQLAMEYMRGQDYRQXTASIE|||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||| m708MPFKPSKRISLLLVLALGACSTSYRPSRAEKANQVSNIKTQLAMEYMRGQDYRQATASIE        10        20        30        40        50        60        70        80        90       100       110       120 a708.pepDALKSDPKNELAWLVRAEIYQYLKVNDKAQESFRQXLSIKPDSAEINNNYXWFLCGRLNR||||||||||||||||||||||||||||||||||| |||||||||||||| ||||||||| m708DALKSDPKNELAWLVRAEIYQYLKVNDKAQESFRQALSIKPDSAEINNNYGWFLCGRLNR        70        80        90       100       110       120       130       140       150       160       170       180 a708.pepPAESMAYFDKALADPTYPXPYIANLNKGICSAKQGQFGLAEAYLKRSLAAQPQFPPAFKE||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||| m708PAESMAYFDKALADPTYPTPYIANLNKGICSAKQGQFGLAEAYLKRSLAAQPQFPPAFKE       130       140       150       160       170       180       190       200       210       220       230       240 a708.pepLARTKMLAGQLGDADYYFKKYQSRVEVLQADDLLLGWKIAKALGNAQAAYEYEAQLQANF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m708LARTKMLAGQLGDADYYFKKYQSRVEVLQADDLLLGWKIAKALGNAQAAYEYEAQLQANF       190       200       210       220       230       240        250a708.pep PYSEELQTVLIGQX |||||||||| ||| m708 PYSEELQTVLTGQX        250The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2379>:

g709.seq 1 ATGTTTGCTT TCAAATCCTT ACTCGATATG CCGCGCGGTG AGGCACTTGC 51CGTCGTCGTC GCTCTGATTG CCGCAATGGG CTATACCATC ATTTCATTGG 101 AGTGGCTGCCGCATATGTCC ATTATTGCCG CCATCGTCGT GCTGATTTTG 151 TACGGCTTGG CGCGCGGTTTGAAATACAAC GATATGCAGG CAGGGATGAT 201 AGGCGCGTTG AATCAGGGTA TGGGCGCGGTTTACCTGTTT TTCTTCATCG 251 GGCTGATGGT CAGCGCGCTG ATGATGAGCG GCGCGATTCCGACGCTGATG 301 TATTACGGTT TCGGGCTGAT TTCCCCGACT TATTTTTATT TTTCCGCCTT351 CGCGCTGTGT TCCGTCATCG GCGTGTCCAT CGGCAGCAGC CTGACCGCCT 401GCGCCACTGT CGGCGTTGCC TTTATGGGGA TGGCGGCGGC GTTTCAGGCC 451 GATATGGCGATGACGgcggg cgcgattgTT tccggTGTGT TTTTCGGCGA 501 TAAAATGTCC CCGCTTTCCGACACCACGGG CATTTCCGCG TCCATCGTCG 551 GTATCGACCT GTTTGAACAC ATCAAAAACATGATGTACAC CACCATCCCT 601 GCGTGGCTTA TCAGCGCGGC ACTGATGCTT TGGCTTCTTCCCAGCGTCGC 651 CGCGCAGGAT TTGAACAGCG TCGAATCCTT CCGCAGCCAG CTTGAAGCCA701 CGGGATTGGT GCACGGCTAT TCGCTGATTC CGTTTGCACT GTTGGTCGTT 751TTGGCATTGA TGCGCGTCAA TGCCGTGGTC GCCATGCTCT TTACCGTCAT 801 TGCCGCCGTTGCCGTAACGT ATCTGCACAG CACGCCCGAT CTGCGTCAGC 851 TCGGCGCGTG GTTTTATGGCGGCTACAAAC TCGAAGGCGA AGCGTTTAAA 901 GACATTGCCA AACTGATTTC GCGCGGCGGCTTGGAGAGTA TGTTCTTTAC 951 GCAGACCATC GTTATCCTCG GTATGAGTTT GGGCGGGCTGCTGTTTGCGC 1001 TCGGTGTGAT TCCTTCCTTG CTGGAGGCCG TCCGTACCTT CTTGACGAAT1051 GCCGGACGCG CGACGTTCAG CGTTGCCATG ACTTCGGTCG GGGTCAATTT 1101CCTGATTGGA GAGCAATATT TGAGCATCCT GCTTTCGGGA GAAACGTTCA 1151 AACCCGTTTACGACAAACTC GGCCTGCATT CGTGCAACCT GTCGCGGACT 1201 CTGGAAGATG CGGGGACGGTGATTAACCCG CTCGTGCCGT GGAGCGTGTG 1251 CGGCGTATTT ATCAGCCACG CCCTTGGCGTACCCGTTTGG GAATATCTGC 1301 CTTATGCCTT TTTCTGCTAT TTGAGTTTGG CTTTAACCCTGTTATTCGGC 1351 TGGACGGGGC TGACTTTGAG CAAAAAATAAThis corresponds to the amino acid sequence <SEQ ID 2380; ORF 709.ng>:

g709.pep 1 MFAFKSLLDM PRGEALAVVV ALIAAMGYTI ISLEWLPHMS IIAAIVVLIL 51YGLARGLKYN DMQAGMIGAL NQGMGAVYLF FFIGLMVSAL MMSGAIPTLM 101 YYGFGLISPTYFYFSAFALC SVIGVSIGSS LTACATVGVA FMGMAAAFQA 151 DMAMTAGAIV SGVFFGDKMSPLSDTTGISA SIVGIDLFEH IKNMMYTTIP 201 AWLISAALML WLLPSVAAQD LNSVESFRSQLEATGLVHGY SLIPFALLVV 251 LALMRVNAVV AMLFTVIAAV AVTYLHSTPD LRQLGAWFYGGYKLEGEAFK 301 DIAKLISRGG LESMFFTQTI VILGMSLGGL LFALGVIPSL LEAVRTFLTN351 AGRATFSVAM TSVGVNFLIG EQYLSILLSG ETFKPVYDKL GLHSCNLSRT 401LEDAGTVINP LVPWSVCGVF ISHALGVPVW EYLPYAFFCY LSLALTLLFG 451 WTGLTLSKK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2381>:

m709.seq 1 ATGTTCGCTT TCAAATCCTT ACTCGATATG CCGCGCGGTG AGGCACTTGC 51CGTCGTCGTC GCTCTGATTG CCGCGATGGG CTATACCATC ATTTCATTGG 101 AGTGGTTGCCGCATATGTCC ATTATTGCCG CCATCGTCGT GCTGATTTTG 151 TACGGCTTGG CGCGCGGTTTGAAATACAAC GATATGCAGC AGGGCATGAT 201 AGGCGCGTTG AATCAGGGTA TGGGCGCGATTTACCTGTTT TTCTTCATCG 251 GGCTGATGGT CAGCGCGCTG ATGATGAGCG GCGCGATTCCGACGCTGATG 301 TATTACGGTT TCGGACTGAT TTCCCCGACT TATTTTTATT TTTCCTCCTT351 CGCGCTGTGT TCCGTCATCG GCGTGTCCAT CGGCAGCAGC CTGACCACCT 401GCGCCACTGT CGGCGTTGCC TTTATGGGGA TGGCGGCGGC GTTTCAGGCC 451 GATATGGCGATGACGGCGGG CGCGATTGTT TCGGGCGCAT TTTTTGGCGA 501 CAAAATGTCC CCGCTTTCGGATACGACGGG TATTTCCGCG TCCATCGTCG 551 GCATCGACTT GTTTGAGCAC ATCAAAAATATGATGTACAC CACCATCCCC 601 GCGTGGCTCA TTAGTGCGGC ACTGATGCTT TGGCTTTTGCCGAATGTCGC 651 CGCGCAGGAT TTGAACAGCG TCGAATCCTT CCGCAGCCAG CTTGAAGCCA701 CGGGATTGGT GCACGGCTAT TCGCTGATTC CGTTTGCGCT GTTGGTCATT 751TTGGCATTGA TGCGCATCAA CGCCGTCGTC GCCATGCTCT TTACCGTCAT 801 GGTTGCCGTTGCTGTAACGT ATCTGCACAG CACGCCCGAT CTGCGTCAGC 851 TCGGTGCGTG GTTTTACGGCGGCTACAAAC TCGAAGGCGA AGCGTTTAAA 901 GATGTTGTCA AACTGATTTC GCGCGGCGGTTTGGAAAGTA TGTTTTTCAC 951 GCAAACCATC GTGATTCTCG GGATGAGTTT GGGCGGACTGTTGTTTGCGC 1001 TCGGTGTGAT TCCTTCCCTG TTGGAGGCCA TCCGTACCTT CTTGACGAAT1051 GCCGGACGCG CGACGTTCAG CGTTGCCATG ACTTCGGTCG GGGTTAATTT 1101CCTGATCGGC GAGCAATATT TGAGTATTTT GTTGTCGGGT GAAACGTTCA 1151 AACCCGTTTACGATAAGCTC GGTCTGCATT CGCGCAATCT GTCGCGGACG 1201 CTGGAAGATG CGGGGACGGTGATTAACCCG CTCGTACCGT GGAGCGTATG 1251 CGGCGTGTTC ATCAGCCACG CGCTGGGCGTGCCGGTTTGG GAATATCTGC 1301 CGTATGCCTT TTTCTGCTAT TTGAGTTTGG CTTTGACCCTGTTATTCGGT 1351 TGGACGGGGC TGACTTTGAG CAAAAAATAAThis corresponds to the amino acid sequence <SEQ ID 2382; ORF 709>:

m709.pep 1 MFAFKSLLDM PRGEALAVVV ALIAAMGYTI ISLEWLPHMS IIAAIVVLIL 51YGLARGLKYN DMQQGMIGAL NQGMGAIYLF FFIGLMVSAL MMSGAIPTLM 101 YYGFGLISPTYFYFSSFALC SVIGVSIGSS LTTCATVGVA FMGMAAAFQA 151 DMAMTAGAIV SGAFFGDKMSPLSDTTGISA SIVGIDLFEH IKNMMYTTIP 201 AWLISAALML WLLPNVAAQD LNSVESFRSQLEATGLVHGY SLIPFALLVI 251 LALMRINAVV AMLFTVMVAV AVTYLHSTPD LRQLGAWFYGGYKLEGEAFK 301 DVVKLISRGG LESMFFTQTI VILGMSLGGL LFALGVIPSL LEAIRTFLTN351 AGRATFSVAM TSVGVNFLIG EQYLSILLSG ETFKPVYDKL GLHSRNLSRT 401LEDAGTVINP LVPWSVCGVF ISHALGVPVW EYLPYAFFCY LSLALTLLFG 451 WTGLTLSKK*m709/g709 96.9% identity in 459 aa overlap        10        20        30        40        50        60 m709.pepMFAFKSLLDMPRGEALAVVVALIAAMGYTIISLEWLPHMSIIAAIVVLILYGLARGLKYN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g709MFAFKSLLDMPRGEALAVVVALIAAMGYTIISLEWLPHMSIIAAIVVLILYGLARGLKYN        10        20        30        40        50        60        70        80        90       100       110       120 m709.pepDMQQGMIGALNQGMGAIYLFFFIGLMVSALMMSGAIPTLMYYGFGLISPTYFYFSSFALC||| ||||||||||||:||||||||||||||||||||||||||||||||||||||:|||| g709DMQAGMIGALNQGMGAVYLFFFIGLMVSALMMSGAIPTLMYYGFGLISPTYFYFSAFALC        70        80        90       100       110       120       130       140       150       160       170       180 m709.pepSVIGVSIGSSLTTCATVGVAFMGMAAAFQADMAMTAGAIVSGAFFGDKMSPLSDTTGISA||||||||||||:|||||||||||||||||||||||||||||:||||||||||||||||| g709SVIGVSIGSSLTACATVGVAFMGMAAAFQADMAMTAGAIVSGVFFGDKMSPLSDTTGISA       130       140       150       160       170       180       190       200       210       220       230       240 m709.pepSIVGIDLFEHIKNMMYTTIPAWLISAALMLWLLPNVAAQDLNSVESFRSQLEATGLVHGY||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||| g709SIVGIDLFEHIKNMMYTTIPAWLISAALMLWLLPSVAAQDLNSVESFRSQLEATGLVHGY       190       200       210       220       230       240       250       260       270       280       290       300 m709.pepSLIPFALLVILALMRINAVVAMLFTVMVAVAVTYLHSTPDLRQLGAWFYGGYKLEGEAFK|||||||||:|||||:||||||||||::|||||||||||||||||||||||||||||||| g709SLIPFALLVVLALMRVNAVVAMLFTVIAAVAVTYLHSTPDLRQLGAWFYGGYKLEGEAFK       250       260       270       280       290       300       310       320       330       340       350       360 m709.pepDVVKLISRGGLESMFFTQTIVILGMSLGGLLFALGVIPSLLEAIRTFLTNAGRATFSVAM|::||||||||||||||||||||||||||||||||||||||||:|||||||||||||||| g709DIAKLISRGGLESMFFTQTIVILGMSLGGLLFALGVIPSLLEAVRTFLTNAGRATFSVAM       310       320       330       340       350       360       370       380       390       400       410       420 m709.pepTSVGVNFLIGEQYLSILLSGETFKPVYDKLGLHSRNLSRTLEDAGTVINPLVPWSVCGVF|||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||| g709TSVGVNFLIGEQYLSILLSGETFKPVYDKLGLHSCNLSRTLEDAGTVINPLVPWSVCGVF       370       380       390       400       410       420       430       440       450       460 m709.pepISHALGVPVWEYLPYAFFCYLSLALTLLFGWTGLTLSKKX|||||||||||||||||||||||||||||||||||||||| g709ISHALGVPVWEYLPYAFFCYLSLALTLLFGWTGLTLSKKX       430       440       450       460The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2383>:

a709.seq 1 ATGTTCGCTT TCNAATCCTT ACTCGATATG CCGCGCGGTG AGGCNCTTGC 51CGTCGTCGTC GCTCTGATTG CCGCGATGGG CTATACCATC ATTTNNTTGG 101 AGTGGCTGCCGCATATGTCC ATTATTGCCG CCATCGTNGT GCTGATTTTG 151 TACGGCTTGG CGCGCGGTTTGAAATACAAC GATATGCAGC AGGGCATGAT 201 AGGCGCGTTG AATCAGGGTA TGGGCGCGATTTACCTNTTT TTCTTCATCG 251 GGCTGATGGT CAGCGCGCTG ATGATGAGCG GCGCGATTCCGACGCTGATG 301 TATTACGGTT TCGGACTGAT TTCCCCGACT TATTTTTATT TTTCCGCCTT351 CGCGCTGTGT TCCGTCATCG GCGTGTCCAT CGGCAGCAGC CTGACCACCT 401GCGCCACTGT CGGCGTTGCC TTNATGGGTA TNNNGNCGGC GTTTCNGGCC 451 NANATGGNGNNGNNGNNGGN CNNGATTGTN NNGGNCGCAT TNTTNGGCGN 501 CAAAATGTCN CCGCTTTCCGATACGNCGGG CATNTCCGCG TCCATTGTCG 551 GTATCGACCT GTTTGAACAC ATCAAAAATATGATGTACAC NACCATTCCC 601 GCGTGGCTCA TCAGTGNNNC ACTGATGCTG TNGCTTCTTCCCAGCGTCGC 651 CGCGCAGGAT TTGAACAGCG TCGAATCCTT CCGCAGCCAG CTTGAAGCCA701 CGGGATTGGT GCACTGCTAT TCGCTGATTC CGTTTGCGCT GTTGGTCGTT 751TTGGCATTGA TGCGCGTCAA TGCCGTGGTC GCTATGCTCT TTACCGTCAT 801 TGCCGCCGTTGCCGTAACGT ATCTGCACAG CACGCCCGAT CTGCGTCAGC 851 TCGGCGCGTG GTTTTACGGCGGCTACAAAC TCGAAGGCGA AGCGTNTANA 901 GACATTGCCA AACTCATTTC TCGCGGCGGTTTGGAAAGTA TGTTTTTCAC 951 GCAGACCATC GTGATTCTTG GGATGAGCCT TGGCGGGCTGCTGTTTGCAC 1001 TGGGCGCGAT TCCTTCCCTG CTGGATGCCG TCCGCAGCTT TTTGACGAAT1051 GCCGGGCGTN CCACATTCAG CGTTGCCATG ACTTCGGTCG GGGTTAATTT 1101CCTGATCGGC GAGCAATATT TGAGTATTTT GTTGTCNGGT GAAACGTTCA 1151 AACCTGTTTACGATAAGCTC GGTCTGCATT CGCGCAATCT GTCGCGGACG 1201 CTGGAAGATG CGGGGACGGTCATCAACCCG CTCGTACCGT GGAGCGTATG 1251 CGGCGTGTTC ATCANCCACG CGCTGGGCGTGCCGGTTTGG GAATATCTGC 1301 CGTATGCCTT TTTCTGCTAT TTGAGTTTGG CTTTGACCCTGTTATTCGGT 1351 TGGACGGGGC TGACTTTGAG CAAAAAATAAThis corresponds to the amino acid sequence <SEQ ID 2384; ORF 709.a>:

a709.pep 1 MFAFXSLLDM PRGEALAVVV ALIAAMGYTI IXLEWLPHMS IIAAIVVLIL 51YGLARGLKYN DMQQGMIGAL NQGMGAIYLF FFIGLMVSAL  MMSGAIPTLM 101 YYGFGLISPTYFYFSAFALC SVIGVSIGSS LTTCATVGVA XMGXXXAFXA 151 XMXXXXXXIV XXAXXGXKMSPLSDTXGXSA SIVGIDLFEH IKNMMYTTIP 201 AWLISXXLML XLLPSVAAQD LNSVESFRSQLEATGLVHCY SLIPFALLVV 251 LALMRVNAVV AMLFTVIAAV AVTYLHSTPD LRQLGAWFYGGYKLEGEAXX 301 DIAKLISRGG LESMFFTQTI VILGMSLGGL LFALGAIPSL LDAVRSFLTN351 AGRXTFSVAM TSVGVNFLIG EQYLSILLSG ETFKPVYDKL GLHSRNLSRT 401LEDAGTVINP LVPWSVCGVF IXHALGVPVW EYLPYAFFCY LSLALTLLFG 451 WTGLTLSKK*a709/m709 91.1% identity in 459 aa overlap        10        20        30        40        50        60 a709.pepMFAFXSLLDMPRGEALAVVVALIAAMGYTIIXLEWLPHMSIIAAIVVLILYGLARGLKYN|||| |||||||||||||||||||||||||| |||||||||||||||||||||||||||| m709MFAFKSLLDMPRGEALAVVVALIAAMGYTIISLEWLPHMSIIAAIVVLILYGLARGLKYN        10        20        30        40        50        60        70        80        90       100       110       120 a709.pepDMQQGMIGALNQGMGAIYLFFFIGLMVSALMMSGAIPTLMYYGFGLISPTYFYFSAFALC|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||| m709DMQQGMIGALNQGMGAIYLFFFIGLMVSALMMSGAIPTLMYYGFGLISPTYFYFSSFALC        70        80        90       100       110       120       130       140       150       160       170       180 a709.pepSVIGVSIGSSLTTCATVGVAXMGXXXAFXAXMXXXXXXIVXXAXXGXKMSPLSDTXGXSA|||||||||||||||||||| ||   || | |  :   ||  |  | ||||||||:| || m709SVIGVSIGSSLTTCATVGVAFMGMAAAFQADMAMTAGAIVSGAFFGDKMSPLSDTTGISA       130       140       150       160       170       180       190       200       210       220       230       240 a709.pepSIVGIDLFEHIKNMMYTTIPAWLISXXLMLXLLPSVAAQDLNSVESFRSQLEATGLVHCY|||||||||||||||||||||||||  ||| |||:||||||||||||||||||||||| | m709SIVGIDLFEHIKNMMYTTIPAWLISAALMLWLLPNVAAQDLNSVESFRSQLEATGLVHGY       190       200       210       220       230       240       250       260       270       280       290       300 a709.pepSLIPFALLVVLALMRVNAVVAMLFTVIAAVAVTYLHSTPDLRQLGAWFYGGYKLEGEAXX|||||||||:|||||:||||||||||::|||||||||||||||||||||||||||||| m709SLIPFALLVILALMRINAVVAMLFTVMVAVAVTYLHSTPDLRQLGAWFYGGYKLEGEAFK       250       260       270       280       290       300       310       320       330       340       350       360 a709.pepDIAKLISRGGLESMFFTQTIVILGMSLGGLLFALGAIPSLLDAVRSFLTNAGRXTFSVAM|::||||||||||||||||||||||||||||||||:|||||:|:|:||||||| |||||| m709DVVKLISRGGLESMFFTQTIVILGMSLGGLLFALGVIPSLLEAIRTFLTNAGRATFSVAM       310       320       330       340       350       360       370       380       390       400       410       420 a709.pepTSVGVNFLIGEQYLSILLSGETFKPVYDKLGLHSRNLSRTLEDAGTVINPLVPWSVCGVF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m709TSVGVNFLIGEQYLSILLSGETFKPVYDKLGLHSRNLSRTLEDAGTVINPLVPWSVCGVF       370       380       390       400       410       420       430       440       450       460 a709.pepIXHALGVPVWEYLPYAFFCYLSLALTLLFGWTGLTLSKKX| |||||||||||||||||||||||||||||||||||||| m709ISHALGVPVWEYLPYAFFCYLSLALILLFGWTGLILSKKX       430       440       450       460 g710.seq not found g710.pep notfoundThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2385>:

m710.seq 1 ATGGAAACCC ACGAAAAAAT CCGCCTGATG CGCGAATTGA ATAAATGGTC 51CCAGGAGGAT ATGGCGGAAA AGCTGGCGAT GTCGGCAGGC GGGTATGCCA 101 AAATCGAACGGGGCGAAACG CAGTTAAATA TCCCGCGTTT GGAGCAGTTG 151 GCTCAGATTT TCAAAATCGATATGTGGGAC TTGCTCAAAT CGGGCGGTGG 201 TGGGATGGTG TTTCAGATTA ATGAAGGTGATAGTGGTGGC GATATTGCGT 251 TGTATGCGTC GGGTGATGTT TCGATGAAAA TAGAATTTTTAAAAATGGAG 301 TTGAAACACT GCAAAGAAAT GTTGGAACAA AAAGACAAAG AAATCGAGCT351 GCTCCGCAAG CTGACCGAAA CCGTTTAAThis corresponds to the amino acid sequence <SEQ ID 2386; ORF 710>:

m710.pep 1 METHEKIRLM RELNKWSQED MAEKLAMSAG GYAKIERGET QLNIPRLEQL 51AQIFKIDMWD LLKSGGGGMV FQINEGDSGG DIALYASGDV SMKIEFLKME 101 LKHCKEMLEQKDKEIELLRK LTETV*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2387>:

a710.seq 1 ATGGAAACCC ACGAAAAAAT CCGCCTGATG CGCGAATTGA ATAAATGGTC 51CCAGGAGGAT ATGGCGGAAA AGCTGGCGAT GTCGGCAGGC GGGTATGCCA 101 AAATCGAACGAGGCGAAACG CAGTTGAATA TCCCGCGTTT GGAGCAGTTG 151 GCGCAGATTT TCAAAATTGATATGTGGGAC TTGCTCAAAT CGGGCGGCGG 201 CGGGATGGTG TTGCAGATTA ACGATGTGGATACCAACAGC GGGGAATTTG 251 CAATCTATAC CGCTCAGGAT GCATCNGGTA AAGCTGGATTTGTTAAAATG 301 GAATTAAAAC ACTGTAAAGA AATGTTGGAA CACAAAGACA AAGAAATCGA351 GCTGCTCCGC AAGCTGACCG AAACCGTTTA AThis corresponds to the amino acid sequence <SEQ ID 2388; ORF 710.a>:

a710.pep 1 METHEKIRLM RELNKWSQED MAEKLAMSAG GYAKIERGET QLNIPRLEQL 51AQIFKIDMWD LLKSGGGGMV LQINDVDTNS GEFAIYTAQD ASGKAGFVKM 101 ELKHCKEMLEHKDKEIELLR KLTETV* a710/m710 85.7% identity in 126 aa overlap          10        20        30        40        50        60 a710.pep  METHEKIRLMRELNKWSQEDMAEKLAMSAGGYAKIERGETQLNIPRLEQLAQIFKIDMWD  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m710  METHEKIRLMRELNKWSQEDMAEKLAMSAGGYAKIERGETQLNIPRLEQLAQIFKIDMWD          10        20        30        40        50        60          70        80        90       100       110       120 a710.pep  LLKSGGGGMVLQINDVDTNSGEFAIYTAQDASGKAGFVKMELKHCKEMLEHKDKEIELLR  ||||||||||:|||: |:: |::|:|:: |:| | |:||||||||||||:||||||||| m710  LLKSGGGGMVFQINEGDSG-GDIALYASGDVSMKIEFLKMELKHCKEMLEQKDKEIELLR          70         80        90       100       110 a710.pep   KLTETVX  ||||||| m710   KLTETVX 120

g711.seq not found

g711.pep not found

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2389>:

m711.seq 1 ATGCCCGCGC CTGATTTGGG ATTTGCCTTA AGTCTGCCGC CAAAAAAGGC 51AATCGAGTGG CTGGAAAGTA AAAAGGTTAC GGCGGAGAGC TACCGCAATC 101 TGACAGCCTCCGAAATTGCC AAAGTCTATA CGATTGCCCG CATGACCGAC 151 TTGGATATGC TCAACGACATCAAAACTTCG ATGGTTGAAT CGGCAAAAAG 201 TGGACAGTCG TTTGACGATT GGCGAAAAGGTATCTTGAAT CTGCTCAGCA 251 ACAAGGGCTG GCTGCATCCG AACGGGCATA ACGGTAAGGATATCATCGAC 301 CCAGCCACCG GCGAGGTATT CGGTTCGCCG CGGAGGTTGG AGACGATTTA351 CCGTACCAAT ATGCAAACTG CCTACAACGC CGGTCAATAT CAAGGATATA 401TGGCAAATAT TGATGCACGA CCTTATTGGA TGTATGACGC GGTAGGCGAC 451 AGCCGCACCCGTCCGGCGCA TTCGGCAATA GACGGGCTGG TGTACCGCTA 501 CGACGACCCG TTTTGGGCAACGTTTTACCC GCCCAACGGC TACAACTGCC 551 GCTGCTCGGT CATCGCGCTG TCGGAGCGGGATGTGGAACG CCAGGGGCGG 601 ATTGTTGGGC AAAGCACGGC GGACAATCTG GTCGAGACCCATAAAATCTA 651 CAACAAAAAA GGCGATACTT ATCTGACCCT TGCCTATAAA GCACCGGATG701 GCAGTCTGTA CACGACCGAT CGAGGATTTG ATTACAACGC CGGACGAATG 751AACTACCGCC CCGATTTAGA CAAGTACGAC CGTGCGTTGG CGCATCAATT 801 TGCCAAAGCGGAAATGGGTG GTGCGGATTT TAAAACCAGC TTTAAACAGC 851 TTGAAAAAGA GTTTTATGAAGTCAAGCAAC GTTTGGATAT TGATGGCAAG 901 CCCGATAAAG AGCAGAAAAT CAAAATCCGAAATGCGCTAT CAAGACAGCT 951 TAAATTTGCT GCGGGTGTAT TGAGCAAGGA AACGCAAGAATTGGCAGGTA 1001 TGACACGAGC GACGGTGTGG CTGTCTGATG ATACGTTGGT TAAACAGGTA1051 GACAGCCGTG AGGGGCAGAA TTTCGATGAC TCCTACTATG CTTTTTTGCC 1101GGATATGCTG CAAAACCCTG AACATGTCAT CCGCGACAAT CGTGAATTGA 1151 TTTTCACAGCTCGCTATAAA GGCTCGGCAT TGTGGGCAGT TTTAAAATAT 1201 ATTAAGGAGG TGGATGAGATTTATCTACAG TCGTACCGAA TCAGTAACGA 1251 CAAAGAGATT GCCAAATTTA TGGCGAAGAAGAAAGTATTG AAATAGThis corresponds to the amino acid sequence <SEQ ID 2390; ORF 711>:

m711.pep 1 MPAPDLGFAL SLPPKKAIEW LESKKVTAES YRNLTASEIA KVYTIARMTD 51LDMLNDIKTS MVESAKSGQS FDDWRKGILN LLSNKGWLHP NGHNGKDIID 101 PATGEVFGSPRRLETIYRTN MQTAYNAGQY QGYMANIDAR PYWMYDAVGD 151 SRTRPAHSAI DGLVYRYDDPFWATFYPPNG YNCRCSVIAL SERDVERQGR 201 IVGQSTADNL VETHKIYNKK GDTYLTLAYKAPDGSLYTTD RGFDYNAGRM 251 NYRPDLDKYD RALAHQFAKA EMGGADFKTS FKQLEKEFYEVKQRLDIDGK 301 PDKEQKIKIR NALSRQLKFA AGVLSKETQE LAGMTRATVW LSDDTLVKQV351 DSREGQNFDD SYYAFLPDML QNPEHVIRDN RELIFTARYK GSALWAVLKY 401IKEVDEIYLQ SYRISNDKEI AKFMAKKKVL K*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2391>:

a711.seq 1 ATGCCCGCGC CTGATTTGGG ATTTGCCTTA AGTCTGCCGC CAAAAAAGGC 51AATCGAGTGG CTGGAAAGTA AAAAGGTTAC GGCGGAGAGC TACCGCAATC 101 TGACAGCCTCCGAAATTGCC AAAGTCTATA CGATTGCCCG CATGACCGAC 151 TTGGATATGC TCAACGACATCAAAACTTCG ATGGTTGAAT CGGCAAAAAG 201 TGGACAGTCG TTTGACGATT GGCGAAAAGGTATCTTGAAT CTGCTCAGCA 251 ACAAGGGCTG GCTGCATCCG AACGGGCATA ACGGTAAGGATATCATCGAC 301 CCAGCCACCG GCGAGGTATT CGGTTCGCCG CGGAGGTTGG AGACGATTTA351 CCGTACCAAC ATGCAAACTG CCTACAACGC CGGTCAATAT CAAGGATATA 401TGGCAAATAT TGATGCACGA CCTTATTGGA TGTATGACGC GGTAGGCGAC 451 AGCCGCACCCGTCCGGCGCA TTCGGCAATA GACGGGCTGG TGTACCGCTA 501 CGACGACCCG TTTTGGGCAACGTTTTACCC GCCCAACGGC TACAACTGCC 551 GTTGCTCGGT CATCGCGCTG TCGGAGCGGGATGTGGAACG CCAGGGGCGG 601 ATTGTCGGGC AAAGCACGTC GGACAATCTT GTTGAGACCCATAAAATCTA 651 CAACAAAAAA GGCGATACTT ATCTGACCCT TGCCTATAAA GCACCGGATG701 GCAGTCTGTA CACGACCGAT CGAGGATTTG ATTACAACGC CGGACGAATG 751AACTACCGCC CCGATTTAGA CAAGTACGAC CGTGCGTTGG CGCATCAATT 801 TGCCAAAGCGGAAATGGGTG GTGCGGATTT TAAAACCAGC TTTAAACAGC 851 TTGAAAAAGA GTTTTATGAAGTCAAGCAAC GTTTGGATAT TGATGGCAAG 901 CCCGATAAAG AGCAGAAAAT CAAAATCCGAAATGCGCTAT CAAGACAGCT 951 TAAATTTGCT GCGGGTGTAT TGAGCAAGGA AACGCAAGAATTGGCAGGTA 1001 TGACACGAGC GACGGTGTGG CTGTCTGATG ATACGTTGGT TAAACAGGTA1051 GACAGCCGTG AAGGGCAGAA TTTCGATGAC TCCTACTATG CTTTTTTGCC 1101GGATATGCTG CAAAACCCTG AACATGTCAT CCGCGACAAT CGTGAATTGA 1151 TTTTCACAGCTCGCTATAAA GGCTCGGCAT TGTGGGCAGT TTTAAAATAT 1201 ATTAAGGAGG TGGATGAGATTTATCTACAG TCGTACCGAA TCAGTAACGA 1251 CAAAGAGATT GCCAAATTTA TGGCGAAGAAGAAAGTATTG AAATAGThis corresponds to the amino acid sequence <SEQ ID 2392; ORF 711.a>:

a711.pep 1 MPAPDLGFAL SLPPKKAIEW LESKKVTAES YRNLTASEIA KVYTIARMTD 51LDMLNDIKTS MVESAKSGQS FDDWRKGILN LLSNKGWLHP NGHNGKDIID 101 PATGEVFGSPRRLETIYRTN MQTAYNAGQY QGYMANIDAR PYWMYDAVGD 151 SRTRPAHSAI DGLVYRYDDPFWATFYPPNG YNCRCSVIAL SERDVERQGR 201 IVGQSTSDNL VETHKIYNKK GDTYLTLAYKAPDGSLYTTD RGFDYNAGRM 251 NYRPDLDKYD RALAHQFAKA EMGGADFKTS FKQLEKEFYEVKQRLDIDGK 301 PDKEQKIKIR NALSRQLKFA AGVLSKETQE LAGMTRATVW LSDDTLVKQV351 DSREGQNFDD SYYAFLPDML QNPEHVIRDN RELIFTARYK GSALWAVLKY 401IKEVDEIYLQ SYRISNDKEI AKFMAKKKVL K* a711/m711 99.8% identity in 431 aaoverlap         10        20        30        40        50        60a711.pep MPAPDLGFALSLPPKKAIEWLESKKVTAESYRNLTASEIAKVYTIARMTDLDMLNDIKTS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m711MPAPDLGFALSLPPKKAIEWLESKKVTAESYRNLTASEIAKVYTIARMTDLDMLNDIKTS        10        20        30        40        50        60        70        80        90       100       110       120 a711.pepMVESAKSGQSFDDWRKGILNLLSNKGWLHPNGHNGKDIIDPATGEVFGSPRRLETIYRTN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m711MVESAKSGQSFDDWRKGILNLLSNKGWLHPNGHNGKDIIDPATGEVFGSPRRLETIYRTN        70        80        90       100       110       120       130       140       150       160       170       180 a711.pepMQTAYNAGQYQGYMANIDARPYWMYDAVGDSRTRPAHSAIDGLVYRYDDPFWATFYPPNG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m711MQTAYNAGQYQGYMANIDARPYWMYDAVGDSRTRPAHSAIDGLVYRYDDPFWATFYPPNG       130       140       150       160       170       180       190       200       210       220       230       240 a711.pepYNCRCSVIALSERDVERQGRIVGQSTSDNLVETHKIYNKKGDTYLTLAYKAPDGSLYTTD||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| m711YNCRCSVIALSERDVERQGRIVGQSTADNLVETHKIYNKKGDTYLTLAYKAPDGSLYTTD       190       200       210       220       230       240       250       260       270       280       290       300 a711.pepRGFDYNAGRMNYRPDLDKYDRALAHQFAKAEMGGADFKTSFKQLEKEFYEVKQRLDIDGK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m711RGFDYNAGRMNYRPDLDKYDRALAHQFAKAEMGGADFKTSFKQLEKEFYEVKQRLDIDGK       250       260       270       280       290       300       310       320       330       340       350       360 a711.pepPDKEQKIKIRNALSRQLKFAAGVLSKETQELAGMTRATVWLSDDTLVKQVDSREGQNFDD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m711PDKEQKIKIRNALSRQLKFAAGVLSKETQELAGMTRATVWLSDDTLVKQVDSREGQNFDD       310       320       330       340       350       360       370       380       390       400       410       420 a711.pepSYYAFLPDMLQNPEHVIRDNRELIFTARYKGSALWAVLKYIKEVDEIYLQSYRISNDKEI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m711SYYAFLPDMLQNPEHVIRDNRELIFTARYKGSALWAVLKYIKEVDEIYLQSYRISNDKEI       370       380       390       400       410       420        430a711.pep AKFMAKKKVLKX |||||||||||| m711 AKFMAKKKVLKX        430

g712.seq not found yet

g712.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2393>:

m712.seq 1 ATGATGCCCC ATATTGATTT TGACACGATT CCGGGCAGCA TCCGCGTGCC 51CGGGCAGTAT ATTGAATTTA ACACCCGCAA TGCCGTACAA GGTTTGCCGC 101 AAAATCCGCAAAAGGTATTG ATGGTTGCAC CCATGCTGAC CGCGGGCATA 151 CAGACCGTCT TAGAGCCGGTGCAACTATTT AGCGATGCCG AGGCGGCCGA 201 TTTGTTCGGA CAAGGCTCGC TGGCGCATTTGATGGTGCGC CAAGCATTTG 251 CCAACAACCC TTATTTGGAT TTGACCGTTA TCGGTATTGCCGACCACAGC 301 GCAGGCGTGC AGGCAACCGC AACCGTTACC CTTTCCGGCA CGGCCACCGC351 GCCGGGCGTG GTGGAAATCA CGATTGGCGG CAAGCAGGTA AGCACGGCCG 401TTAACACCGG CGAGACCGCC GCCACAGTGG CAGACCGTCT GAAAACCGCC 451 ATCACTGCCGCCGATGTAAC CGTTACCGCA TCCGGCAGCG GCGCAGCCGT 501 TACGCTGACG GCCAAACACAAAGGCGAGAT CGGCAACGAG AGCGGCTTAA 551 CCGTGAGCAC CGGCAATACC GGCCTAACTTATCAAGCCAA TGCCTTTACC 601 GGCGGTGCCA AAAATGCGGA CATTGCCACG GCCTTGTCCAAAGTGGCGGG 651 CAAGCATTAT CACATTATTT GCAGCCCGTT TAGCGATGAC GCCAACGCCA701 AAGCCTTGAG CAACCATATT ACCAACGTAT CCAACGCCAT CGAGCAGCGC 751GGCTGTATCG GCGTATTGGG TATGAGTGCG GCCTTGAGCA CGGCCACCAC 801 CGCTACCGGCGAAATCAACG ACGGCCGCAT GACCTGTGCT TGGTACAAAG 851 GTGCGGTAGA GCCAAACGGCATCATCGCCG CAGGTTATGC GGCGGTGTTG 901 GCCTTTGAAG AAGACCCTGC CAAGCCGCTGAACACGCTGG AAATCAAAGG 951 GCTGGCCGTT ACACCTGATG CGCAATGGCC GCTGTTTGCAGAATGCAACA 1001 ATGCGCTGTA CAACGGCTTG ACCCCGCTCA CAGTGGTCAA CAACCGCGTG1051 CAGATTATGC GTGCCGTATC CACCTATACC AAGTCGGCCA ACAACACCGA 1101CGACCCGGCA CTACTCGACA TTACCACCAT CCGCACGCTG GATTATGTGC 1151 GCCGCAGCGTTAAAGAGCGC ATTGCCCTGC GTTTTCCGCG CGACAAATTG 1201 AGCGACCGCC TGCTGCCCAAGGTTAAGAGC GAGATTTTGG ACGTGCTGAT 1251 TAAGCTCGAC CAAGCCGAAA TCATCGAAAACGCCGAGGCC AACAAAGGCA 1301 AGCTGGTGGT GGCGCGTGCG CAAAACGACC CCAACCGTGTTAATGCCATT 1351 ATCACTGCCG ATGTGGTCAA CGGCCTGCAC GTCTTTGCCG GGCGCATTGA1401 TTTGATTTTG TAAThis corresponds to the amino acid sequence <SEQ ID 2394; ORF 712>:

m712.pep 1 MMPHIDFDTI PGSIRVPGQY IEFNTRNAVQ GLPQNPQKVL MVAPMLTAGI 51QPALEPVQLF SDAEAADLFG QGSLAHLMVR QAFANNPYLD LTVIGIADHS 101 AGVQATATVTLSGTATAPGV VEITIGGKQV STAVNTGETA ATVADRLKTA 151 ITAADVTVTA SGSGAAVTLTAKHKGEIGNE SGLTVSTGNT GLTYQANAFT 201 GGAKNADIAT ALSKVAGKHY HIICSPFSDDANAKALSNHI TNVSNAIEQR 251 GCIGVLGMSA ALSTATTATG EINDGRMTCA WYKGAVEPNGIIAAGYAAVL 301 AFEEDPAKPL NTLEIKGLAV TPDAQWPLFA ECNNALYNGL TPLTVVNNRV351 QIMRAVSTYT KSANNTDDPA LLDITTIRTL DYVRRSVKER IALRFPRDKL 401SDRLLPKVKS EILDVLIKLD QAEIIENAEA NKGKLVVARA QNDPNRVNAI 451 IPADVVNGLHVFAGRIDLIL *

a712.seq not found yet

a712.pep not found yet

g713.seq not found yet

g713.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2395>:

m713.seq 1 ATGCAAAATA ATTCATACGG CTATGCCGTG TCGGTGCGCG TGGGCGGTAA 51AGAGCACCGC CACTGGGAGC GCTACGACAT CGACAGCGAC TTTTTAATCC 101 CTGCCGACAGCTTCGATTTT GTCATCGGCA GGTTGGGACC GGAGGCGGCC 151 ATACCCGATT TAAGCGGAGAGAGCTGCGAG GTAGTGATAG ACGGGCAAAT 201 CGTGATGACG GGCATCATCG GCAGCCAGCGCCACGGCAAA AGCAAGGGCA 251 GCCGCGAGTT GAGCTTGAGC GGGCGTGATT TGGCCGGTTTTTTGGTGGAT 301 TGCTCCGCGC CGCAGCTCAA TGTAAAGGGC ATGACGGTAT TGGATGCAGC351 CAAAAAGCTG GCCGCGCCGT GGCCGCAGAT TAAAGCGGTG GTGCTTAAGG 401CCGAAAACAA CCCCGCTTTG GGCAAAATCG ACATCGAGCC GGGCGAAACC 451 GTATGGCAGGCATTAACCCA TATTGCCAAC TCGGTCGGGC TGCATCCGTG 501 GCTGGAGCCG GACGGCACGTTGGTGGTGGG CGGTGCGGAT TACAGCAGCC 551 CGCCGGTGGC GACATTGTGT TGGAGCCGCACCGACAGCCG CTGCAATATC 601 GAGCGCATGG ACATTGAGTG GGATACCGAC AACCGCTTTTCCGAGGTTAC 651 TTTTTTGGCG CAATCGCACG GCCGCAGCGG CGACAGCGCC AAACACGATT701 TAAAGTGGGT GTACAAAGAC CCGACGATGA CGCTGCACCG CCCTAAAACG 751GTGGTGGTGT CCGATGCCGA CAATTTGGCC GCATTGCAAA AGCAGGCTAA 801 AAAGCAGCTGGCCGACTGGC GGCTGGAGGG ATTTACACTC ACGATAACCG 851 TGGGCGGCCA TAAAACCCGCGACGGCGTAT TGTGGCAACC TGGCCTGCGT 901 GTGCATGTGA TCGACGACGA GCACGGTATCGATGCGGTGT TTTTTCTGAT 951 GGGGCGGCGG TTTATGCTAT CCCGCATGGA TGGTACGCAAACCGAGCTGC 1001 GGCTCAAAGA GGACGGTATT TGGACACCCG ACGCTTACCC CAAAAAGGCC1051 GAGGCGGCGC GCAAGCGCAA AGGCAAACGC AAAGGCGTGA GCCATAAGGG 1101CAAAAAAGGC GGCAAAAAAC AAGCAGAAAC GGCGGTGTTT GAATGAThis corresponds to the amino acid sequence <SEQ ID 2396; ORF 713>:

m713.pep 1 MQNNSYGYAV SVRVGGKEHR HWERYDIDSD FLIPADSFDF VIGRLGPEAA 51IPDLSGESCE VVIDGQIVMT GIIGSQRHGK SKGSRELSLS GRDLAGFLVD 101 CSAPQLNVKGMTVLDAAKKL AAPWPQIKAV VLKAENNPAL GKIDIEPGET 151 VWQALTHIAN SVGLHPWLEPDGTLVVGGAD YSSPPVATLC WSRTDSRCNI 201 ERMDIEWDTD NRFSEVTFLA QSHGRSGDSAKHDLKWVYKD PTMTLHRPKT 251 VVVSDADNLA ALQKQAKKQL ADWRLEGFTL TITVGGHKTRDGVLWQPGLR 301 VHVIDDEHGI DAVFFLMGRR FMLSRMDGTQ TELRLKEDGI WTPDAYPKKA351 EAARKRKGKR KGVSHKGKKG GKKQAETAVF E*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2397>:

a713.seq 1 ATGCAAAATA ATTCATACGG CTATGCCGTG TCGGTGCGCG TGGGCGGTAA 51AGAGCACCGC CACTGGGAGC GCTACGACAT CGACAGCGAC TTTTTAATCC 101 CTGCCGACAGCTTCGATTTT GTCATCGGCA GGTTGGGGCC GGAGGCGGCC 151 ATACCCGATT TAAGCGGAGAGAGCTGCGAG GTAGTGATAG ACGGGCAAAT 201 CGTGATGACG GGCATCATCG GCAGCCAGCGCCACGGCAAA AGCAAGGGCG 251 GCCGCGAGTT GAGCTTGAGC GGGCGTGATT TGGCCGGTTTTTTGGTGGAT 301 TGCTCCGCGC CGCAGCTCAA TGTAAAGGGC ATGACGGTAT TGGATGCAGC351 CAAAAAGCTG GCCGCGCCGT GGCCGCAGAT TAAAGCGGTG GTGCTTAAGG 401TCGAAAACAA CCCCGCTTTG GACAAAATCG ACATCGAGCC GGGCGAAACC 451 GTATGGCAGGCATTAACCCA TATTGCCAAC TCGGTCGGGC TGCATCCGTG 501 GCTGGAGCCG GACGGCACGTTGGTGGTGGG CGGTGTGGAT TACAGCAGCC 551 CGCCGGTGGC GACATTGTGT TGGAGCCGCACCGACAGCCG CCGCAATATC 601 GAGCGCATGG ACATTGAGTG GGATACCGAC AACCGCTTTTCTGAGGTTAC 651 TTTTTTGGCG CAATCGCACG GCCGCAGCGG CGACAGCGCC AAACACGATT701 TAAAGTGGGT GTACAAAGAC CCGACGATGA CGCTGCACCG CCCTAAAACG 751GTGGTGGTGT CCGATGCCGA CAATTTGGCC GCATTGCAAA AGCAGGCTAA 801 AAAGCAGCTGGCCGACTGGC GGCTGGAGGG ATTTACACTC ACGATAACCG 851 TGGGCGGCCA TAAAACCCGCGACGGCGTAT TGTGGCAACC TGGCCAGCGT 901 GTGCATGTGA TCGACGACGA GCACGGTATCGATGCGGTGT TTTTTCTGAT 951 GGGGCGGCGG TTTATGCTAT CTCGCATGGA TGGCACGCAAACCGAGCTGC 1001 GGCTCAAAGA GGACGGTATT TGGACACCCG ACGCTTACCC CAAAAAGGCC1051 GAGGCGGCGC GCAAGCGCAA AGGCAAACGC AAAGGCGTGA GCCATAAGGG 1101CAAAAAAGGC GGCAAAAAAC AAGCAGAAAC GGCGGTGTTT GAATGAThis corresponds to the amino acid sequence <SEQ ID 2398; ORF 713.a>:

a713.pep 1 MQNNSYGYAV SVRVGGKEHR HWERYDIDSD FLIPADSFDF VIGRLGPEAA 51IPDLSGESCE VVIDGQIVMT GIIGSQRHGK SKGGRELSLS GRDLAGFLVD 101 CSAPQLNVKGMTVLDAAKKL AAPWPQIKAV VLKVENNPAL DKIDIEPGET 151 VWQALTHIAN SVGLHPWLEPDGTLVVGGVD YSSPPVATLC WSRTDSRRNI 201 ERMDIEWDTD NRFSEVTFLA QSHGRSGDSAKHDLKWVYKD PTMTLHRPKT 251 VVVSDADNLA ALQKQAKKQL ADWRLEGFTL TITVGGHKTRDGVLWQPGQR 301 VHVIDDEHGI DAVFFLMGRR FMLSRMDGTQ TELRLKEDGI WTPDAYPKKA351 EAARKRKGKR KGVSHKGKKG GKKQAETAVF E* a713/m713 98.4% identity in 381aa overlap         10        20        30        40        50        60a713.pep MQNNSYGYAVSVRVGGKEHRHWERYDIDSDFLIPADSFDFVIGRLGPEAAIPDLSGESCE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m713MQNNSYGYAVSVRVGGKEHRHWERYDIDSDFLIPADSFDFVIGRLGPEAAIPDLSGESCE        10        20        30        40        50        60        70        80        90       100       110       120 a713.pepVVIDGQIVMTGIIGSQRHGKSKGGRELSLSGRDLAGFLVDCSAPQLNVKGMTVLDAAKKL|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| m713VVIDGQIVMTGIIGSQRHGKSKGSRELSLSGRDLAGFLVDCSAPQLNVKGMTVLDAAKKL        70        80        90       100       110       120       130       140       150       160       170       180 a713.pepAAPWPQIKAVVLKVENNPALDKIDIEPGETVWQALTHIANSVGLHPWLEPDGTLVVGGVD|||||||||||||:|||||| |||||||||||||||||||||||||||||||||||||:| m713AAPWPQIKAVVLKAENNPALGKIDIEPGETVWQALTHIANSVGLHPWLEPDGTLVVGGAD       130       140       150       160       170       180       190       200       210       220       230       240 a713.pepYSSPPVATLCWSRIDSRRNIERMDIEWDIDNRFSEVTFLAQSHGRSGDSAKHDLKWVYKD||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||| m713YSSPPVATLCWSRIDSRCNIERMDIEWDIDNRFSEVTFLAQSHGRSGDSAKHDLKWVYKD       190       200       210       220       230       240       250       260       270       280       290       300 a713.pepPTMTLHRPKTVVVSDADNLAALQKQAKKQLADWRLEGFTLTITVGGHKTRDGVLWQPGQR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| | m713PTMTLHRPKTVVVSDADNLAALQKQAKKQLADWRLEGFTLTITVGGHKTRDGVLWQPGLR       250       260       270       280       290       300       310       320       330       340       350       360 a713.pepVHVIDDEHGIDAVFFLMGRRFMLSRMDGTQTELRLKEDGIWTPDAYPKKAEAARKRKGKR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m713VHVIDDEHGIDAVFFLMGRRFMLSRMDGTQTELRLKEDGIWTPDAYPKKAEAARKRKGKR       310       320       330       340       350       360       370       380 a713.pep KGVSHKGKKGGKKQAETAVFEX|||||||||||||||||||||| m713 KGVSHKGKKGGKKQAETAVFEX        370       380

g714.seq not found yet

g714.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2399>:

m714.seq 1 ATGAGCTATC AAGACATCTT GCGGGGCCTG TTGCCCCCCG TGTCGTATGC 51CCGCAATGCC CCGCGTGTGC GGGCGCAGGC AGAAATAGAC GGCGCAGCGC 101 TGGATGCGGTGGCGGAATCG GCTCAAAGCG TTGCCGATGC CGTCGACCCG 151 CGCAGCGCCG GCCAAATGCTGGCCGATTGG GAGCGCGTAT TAGGTTTGGA 201 CGGTACGGGC AAAAACCGCC AGCACCGTGTGTTGGCCGTC ATGGCCAAGC 251 TAAACGAAAC AGGCGGCTTG AGTATTCCTT ATTTTGTGCGTTTGGCCGAG 301 GCGGCGGGCT ATCAAATCCA AATCGACGAA CCGCAGCCGT TCCGCGCCGG351 TGTAAACCGC GCCGGCGACC GTCTTGCGCC GCAGGAAATC ATGTGGGTGT 401GGCACGTTAA CGTGCGCGGC GGCAACAACC GCATTACCCG ATTCCGCGCC 451 GGTATCTCGGCGGCGGGCGA CAGGCTGACC GATTACAGCG ATGCCGTGAT 501 CGAGAGCCTG TTCAACCGCCTCAAGCCCGC CCACACCGCT ATCCGATTTA 551 CCTACCGCTA AThis corresponds to the amino acid sequence <SEQ ID 2400; ORF 714>:

m714.pep 1 MSYQDILRGL LPPVSYARNA PRVRAQAEID GAALDAVAES AQSVADAVDP 51RSAGQMLADW ERVLGLDGTG KNRQHRVLAV MAKLNETGGL SIPYFVRLAE 101 AAGYQIQIDEPQPFRAGVNR AGDRLAPQEI MWVWHVNVRG GNNRITRFRA 151 GISAAGDRLT DYSDAVIESLFNRLKPAHTA IRFTYR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2401>:

a714.seq 1 ATGAGCTATC AAGACATCTT GCGGGGTCTG TTGCCCCCCG TGTCGTATGC 51CCGCAATGCC CCGCGTGTGC GGGCGCAGGC AGAAATAGAC GGCGCAGCGC 101 TGGATGCGGTGGCGGAATCG GCTCAAAGCG TTGCCGATGC CGTCGACCCG 151 AGCAGCGCCG GCCAAATGCTGGCCGATTGG GAGCGCGTAT TAGGTTTGGA 201 CGGTACGGGC AAAAACCGCC AGCGCCGTGTGTTGGCCGTC ATGGCCAAGC 251 TAAACGAAAC AGGCGGCTTG AGTATTCCTT ATTTTGTGCGTTTGGCCGAG 301 GCGGCGGGCT ATCAAATCCA AATCGACGAA CCGCAGCCGT TCCGCGCCGG351 TGTAAACCGC GCCGGCGACC GTCTTGCGCC GCAGGAAATC ATGTGGGTGT 401GGCACGTTAA CGTGCGCGGC GGCAACAACC GCATTACCCG ATTCCGCGCC 451 GGTATCTCGGCGGCGGGCGA CAGGCTGACC GATTACAGCG ATGCCGTGAT 501 CGAGAGCCTG TTCAACCGCCTCAAGCCCGC CCACACCGCT ATCCGATTTA 551 CCTACCGATA AThis corresponds to the amino acid sequence <SEQ ID 2402; ORF 714.a>:

a714.pep 1 MSYQDILRGL LPPVSYARNA PRVRAQAEID GAALDAVAES AQSVADAVDP 51SSAGQMLADW ERVLGLDGTG KNRQRRVLAV MAKLNETGGL SIPYFVRLAE 101 AAGYQIQIDEPQPFRAGVNR AGDRLAPQEI MWVWHVNVRG GNNRITRFRA 151 GISAAGDRLT DYSDAVIESLFNRLKPAHTA IRFTYR* a714/m714 98.9% identity in 186 aa overlap        10        20        30        40        50        60 a714.pepMSYQDILRGLLPPVSYARNAPRVRAQAEIDGAALDAVAESAQSVADAVDPSSAGQMLADW|||||||||||||||||||||||||||||||||||||||||||||||||| ||||||||| m714MSYQDILRGLLPPVSYARNAPRVRAQAEIDGAALDAVAESAQSVADAVDPRSAGQMLADW        10        20        30        40        50        60        70        80        90       100       110       120 a714.pepERVLGLDGTGKNRQRRVLAVMAKLNETGGLSIPYFVRLAEAAGYQIQIDEPQPFRAGVNR||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||| m714ERVLGLDGIGKNRQHRVLAVMAKLNEIGGLSIPYFVRLAEAAGYQIQIDEPQPFRAGVNR        70        80        90       100       110       120       130       140       150       160       170       180 a714.pepAGDRLAPQEIMWVWHVNVRGGNNRITRFRAGISAAGDRLTDYSDAVIESLFNRLKPAHTA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m714AGDRLAPQEIMWVWHVNVRGGNNRITRFRAGISAAGDRLIDYSDAVIESLFNRLKPAHTA       130       140       150       160       170       180 a714.pepIRFTYRX ||||||| m714 IRFTYRX

g715.seq not found yet

g715.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2403>:

m715.seq 1 ATGATTGATG TCAAAATAGA CAATATCTTT GTCGTCCTAA ACCAAATCGA 51GCGGCTTGGC AACGGGATCG AAAACCGCTA CCTGCTGATG CGCCGACTGT 101 CCGAAACCATGCACACGGCG GTCAAGCTCA ATTTCCGCTA CGCAGGCCGT 151 CCGAAATGGG TTGGGCTAAAATACCGCGAC GGCAAGCCGC TTTCGGATTC 201 GGGTCGTCTG AAAGACAGTT TTTCCACACTGTCAGACAAC GATACAGCCC 251 TTGTCGGTAC GAATATCGTC TATGCCGCCA TCCACAACTTCGGCGGTATG 301 GCGGGGCGCA ACCGCAAAGT TCGGATTCCG CAACGGGAAT TTTTGACGCT351 GACGGACGAC GACAAACAGG CTTTGATGGA CGATGTGCAG GATTATTTTT 401CGGGTCTGAT ACCGTGAThis corresponds to the amino acid sequence <SEQ ID 2404; ORF 715>:

m715.pep 1 MIDVKIDNIF VVLNQIERLG NGIENRYLLM RRLSETMHTA VKLNFRYAGR 51PKWVGLKYRD GKPLSDSGRL KDSFSTLSDN DTALVGTNIV YAAIHNFGGM 101 AGRNRKVRIPQREFLTLTDD DKQALMDDVQ DYFSGLIP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2405>:

a715.seq 1 ATGATTGATG TCAAAATAGA CAATATCTTT GTCGTCCTAA ACCAAATCGA 51GCGGCTTGGC AACGGGATCG AAAACCGCTA CCTGCTGATG CGCCGACTGT 101 CCGAAACCATGCACACGGCG GTCAAGCTCA ATTTCCGCTA CGCAGGCCGT 151 CCGAAATGGT TGGGGCTAAAATACCGCGAC GGCAAGCCGC TTTCGGATTC 201 GGGTCGTCTG AAAGACAGTT TTTCCACACTGTCAGACAAC GATACAGCCC 251 TTGTCGGTAC GAATATCGTC TATGCCGCCA TCCACAACTTCGGCGGTATG 301 GCGGGGCGCA ACCGCAAAGT TCGGATTCCG CAACGGGAAT TTTTGACGCT351 GACGGACGAC GACAAACAGG CTTTGATGGA CGATGTGCAG GATTATTTTT 451CGGGTCTGAT ACCGTGAThis corresponds to the amino acid sequence <SEQ ID 2406; ORF 715.a>

a715.pep 1 MIDVKIDNIF VVLNQIERLG NGIENRYLLM RRLSETMHTA VKLNFRYAGR 51PKWLGLKYRD GKPLSDSGRL KDSFSTLSDN DTALVGTNIV YAAIHNFGGM 101 AGRNRKVRIPQREFLTLTDD DKQALMDDVQ DYFSGLIP*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2407>:

g716.seq 1 ATGAACAAAA ATATTGCTGC CGCACTCGCC GGTGCTTTAT CCCTGTCTCT 51GGCCGCCGGC GCCGTTGCCG CCCACAAACC GGCAAGCAAC GCAACAGGCG 101 TTCAAAAATCCGCCCAAGGC TCTTGCGGCG CATCCAAATC TGCCGAAGGT 151 TCGTGCGGCG CATCCAAATCTGCCGAAGGT TCGTGCGGCG CGGCTGCTTC 201 TAAAGCAGGC GAAGGCAAAT GCGGCGAGGGCAAATGCGGT GCAACTGTAA 251 AAAAAGCCCA CAAACACACC AAAGCATCTA AAGCCAAAGCCAAATCTGCC 301 GAAGGCAAAT GCGGCGAAGG CAAATGCGGT TCTAAATAAThis corresponds to the amino acid sequence <SEQ ID 2408; ORF 716.ng>:

g716.pep 1 MNKNIAAALA GALSLSLAAG AVAAHKPASN ATGVQKSAQG SCGASKSAEG 51SCGASKSAEG SCGAAASKAG EGKCGEGKCG ATVKKAHKHT KASKAKAKSA 101 EGKCGEGKCGSK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2409>:

m716.seq 1 ATGAACAAAA ACATTGCTGC CGCTCTCGCC GGTGCTTTAT CCCTGTCTTT 51GGCCGCCGGT GCAGTTGCTG CCAACAAACC GGCAAGCAAC GCAACAGGCG 101 TTCATAAATCCGCCCATGGC TCTTGCGGCG CGTCCAAATC TGCCGAAGGT 151 TCGTGCGGCG CGGCTGGTTCTAAAGCAGGC GAAGGCAAAT GCGGCGAGGG 201 CAAATGCGGT GCGACCGTAA AAAAAACCCACAAACACACC AAAGCATCTA 251 AAGCCAAGGC CAAATCTGCC GAAGGCAAAT GCGGCGAAGGCAAATGCGGT 301 TCTAAATAAThis corresponds to the amino acid sequence <SEQ ID 2410; ORF 716>:

m716.pep 1 MNKNIAAALA GALSLSLAAG AVAANKPASN ATGVHKSAHG SCGASKSAEG 51SCGAAGSKAG EGKCGEGKCG ATVKKTHKHT KASKAKAKSA EGKCGEGKCG 101 SK* m716/g71686.6% identity in 112 aa overlap        10        20        30        40        50 m716.pepMNKNIAAALAGALSLSLAAGAVAANKPASNATGVHKSAHGSCGASKSAEGSCGA------||||||||||||||||||||||||:|||||||||:|||:||||||||||||||| g716MNKNIAAALAGALSLSLAAGAVAAHKPASNATGVQKSAQGSCGASKSAEGSCGASKSAEG        10        20        30        40        50        60        60        70        80        90       100 m716.pep----AGSKAGEGKCGEGKCGATVKKTHKHTKASKAKAKSAEGKCGEGKCGSKX    |:|||||||||||||||||||:||||||||||||||||||||||||||| g716SCGAAASKAGEGKCGEGKCGATVKKAHKHTKASKAKAKSAEGKCGEGKCGSKX        70        80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2411>:

a716.seq 1 ATGAACAAAA ACATTGCTGC CGCACTCGCC GGTGCTTTAT CCCTGTCTTT 51GGCCGCCGGT GCAGTTGCTG CCAACAAACC GGCAAGCAAC GCAACAGGCG 101 TTCATAAATCCGCCCATGGC TCTTGCGGCG CGTCCAAATC TGCCGAAGGT 151 TCGTGCGGCG CGGCTGGTTCTAAAGCAGGC GAAGGCAAAT GCGGCGAGGG 201 CAAATGCGGT GCGACCGTAA AAAAAACCCACAAACACACC AAAGCATCTA 251 AAGCCAAGGC CAAATCTGCC GAAGGCAAAT GCGGCGAAGGCAAATGCGGT 301 TCTAAATAAThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2412.a>:

a716.pep 1 MNKNIAAALA GALSLSLAAG AVAANKPASN ATGVHKSAHG SCGASKSAEG 51SCGAAGSKAG EGKCGEGKCG ATVKKTHKHT KASKAKAKSA EGKCGEGKCG 101 SK* a716/m716100.0% identity in 102 aa overlap        10        20        30        40        50        60 a716.pepMNKNIAAALAGALSLSLAAGAVAANKPASNATGVHKSAHGSCGASKSAEGSCGAAGSKAG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m716MNKNIAAALAGALSLSLAAGAVAANKPASNATGVHKSAHGSCGASKSAEGSCGAAGSKAG        10        20        30        40        50        60        70        80        90       100 a716.pepEGKCGEGKCGATVKKTHKHTKASKAKAKSAEGKCGEGKCGSKX||||||||||||||||||||||||||||||||||||||||||| m716EGKCGEGKCGATVKKTHKHTKASKAKAKSAEGKCGEGKCGSKX        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2413>:

g717.seq 1 ATGGACACAA AAGAAATCCT CGGCTACGCG GCAGGCTCGA TCGGCAGCGC 51GGTTTTAGCC GTCATCATCC TGCCGCTGCT GTCGTGGTAT TTCcccgCCG 101 ACGACATCGGGCGCATCGTG CTGATGCAGA CGGCGGCGGG ACTGACGGTG 151 TCGGTATTGT GCCTCGGGCTGGATCAGGCA TACGTCCGCG AATACTATGC 201 CGCCGCCGAC AAAGACACTT TGTTCAAAACCCTGTTCCTG CCGCCGCTGC 251 TGTTTTCCGC CGCGATAGCC GCCCTGCTGC TTTCCCGCCCGTCCCTGCCG 301 TCTGAAATCC TGTTTTCGCT CGACGATGCC GCCGCCGGCA TCGGGCTGGT351 GCTGTTTGAA CTGAGCTTCC TGCCCATCCG CTTTCTCTTA CTGGTTTTGC 401GTATGGAAGG GCGCGCCCTT GCCTTTTCGT CCGCGCAACT CGTGCCCAAA 451 CTCGCCATTCTGCTGCTGTT GCCGCTGACG GTCGGGCTGC TGCACTTTCC 501 GGCGAACACC TCCGTCCTGACCGCCGTTTA CGCGCTGGCA AACCTTGCCG 551 CCGCCGCCTT TTTGCTGTTT CAAAACCGATGCCGTCTGAA GGCCGTCCGG 601 CGCGCGCCGT TTTCGCCCGC CGTCCTGCAC CGGGGGCTGCGCTACGGCAT 651 ACCGCTCGCA CTGAGCAGCC TTGCCTATTG GGGGCTGGCA TCCGCCGACC701 GTTTGTTCCT GAAAAAATAT GCGGGCCTGG AACAGCTCGG CGTTTATTCG 751ATGGGTATTT CGTTCGGCGG GGCGGCATTA TTGCTCCAAA GCATCTTTTC 801 AACGGTCTGGACACCGTATA TTTTCCGTGC AATCGAAGAA AACGCCACGC 851 CCGCCCGCCT CTCGGCAACGGCAGAATCCG CCGCCGCCCT GCTTGCCTCC 901 GCCCTCTGCC TGACCGGAAT TTTCTCGCCCCTCGCCTCCC TCCTGCTGCC 951 GGAAAACTAC GCCGCCGTCC GGTTTACCGT CGTATCGTGTATGCTGccgc 1001 cgctGTTTTA CACGCTGACC GAAATCAGCG GCATCGGTTT GAACGTCGTC1051 CGCAAAACGC GTCCGATCGC GCTTGCCACC TTGGGCGCGC TGGCGGCAAA 1101CCTGCTGCTG CTGGGGCTTG CCGTACCGTC CGGCGGCACG CGCGGCGCGG 1151 CGGTTGCCTGTGCCGCCTCA TTCTGGTTGT TTTTTGTTTT CAAGACAGAA 1201 AGCTCCTGCC GCCTGTGGCAGCCGCTCAAA CGCCTGCCGC TTTATATGCA 1251 CACATTGTTC TGCCTgGCCT CCTCGGCGGCCTACACCTGC TTCGGCACAC 1301 CGGCAAACTA CCCcctgttt gccggcgtAT GGGCGGCATATCTGGCAGGC 1351 TGCATCCTGC GCCACCGGAA AAATTTGCAC AAACTGTTTC ATTATTTGAA1401 AAAACAAGGT TTCCCATTAT GAThis corresponds to the amino acid sequence <SEQ ID 2414; ORF 717.ng>:

g717.pep 1 MDTKEILGYA AGSIGSAVLA VIILPLLSWY FPADDIGRIV LMQTAAGLTV 51SVLCLGLDQA YVREYYAAAD KDTLFKTLFL PPLLFSAAIA ALLLSRPSLP 101 SEILFSLDDAAAGIGLVLFE LSFLPIRFLL LVLRMEGRAL AFSSAQLVPK 151 LAILLLLPLT VGLLHFPANTSVLTAVYALA NLAAAAFLLF QNRCRLKAVR 201 RAPFSPAVLH RGLRYGIPLA LSSLAYWGLASADRLFLKKY AGLEQLGVYS 251 MGISFGGAAL LLQSIFSTVW TPYIFRAIEE NATPARLSATAESAAALLAS 301 ALCLTGIFSP LASLLLPENY AAVRFTVVSC MLPPLFYTLT EISGIGLNVV351 RKTRPIALAT LGALAANLLL LGLAVPSGGT RGAAVACAAS FWLFFVFKTE 401SSCRLWQPLK RLPLYMHTLF CLASSAAYTC FGTPANYPLF AGVWAAYLAG 451 CILRHRKNLHKLFHYLKKQG FPL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2415>:

m717.seq 1 ATGGACACAA AAGAAATCCT CGGCTACGCG GCAGGCTCGA TCGGCAGCGC 51GGTTTTAGCC GTCATCATCC TGCCGCTGCT GTCGTGGTAT TTCCCCGCCG 101 ACGACATCGGGCGCATCGTG CTGATGCAGA CGGCGGCGGG GCTGACGGTG 151 TCGGTGTTGT GCCTCGGGCTGGATCAGGCA TACGTCCGCG AATACTATGC 201 CACCGCCGAC AAAGACACCT TGTTCAAAACCCTGTTCCTG CCGCCGCTGC 251 TGTCTGCCGC CGCGATAGCC GCCCTGCTGC TTTCCCGCCCGTCCCTGCCG 301 TCTGAAATCC TGTTTTCACT CGACGATGCC GCCGCCGGCA TCGGGCTGGT351 GCTGTTTGAA CTGAGCTTCC TGCCCATCCG CTTTCTCTTA CTGGTTTTGC 401GTATGGAAGG ACGCGCCCTT GCCTTTTCGT CCGCGCAACT CGTGCCCAAG 451 CTCGCCATCCTGCTGCTGCT GCCGCTGACG GTCGGGCTGC TGCACTTTCC 501 AGCGAACACC GCCGTCCTGACCGCCGTTTA CGCGCTGGCA AACCTTGCCG 551 CCGCCGCCTT TTTGCTGTTT CAAAACCGATGCCGTCTGAA GGCCGTCCGG 601 CACGCACCGT TTTCGCCCGC CGTCCTGCAC CGGGGGCTGCGCTACGGCAT 651 ACCGATCGCA CTGAGCAGCA TCGCCTATTG GGGGCTGGCA TCCGCCGACC701 GTTTGTTCCT GAAAAAATAT GCCGGCCTGG AACAGCTCGG CGTTTATTCG 751ATGGGTATTT CGTTCGGCGG GGCGGCATTA TTGTTCCAAA GCATCTTTTC 801 AACGGTCTGGACACCGTATA TTTTCCGCGC AATCGAAGAA AACGCCCCGC 851 CCGCCCGCCT CTCGGCAACGGCAGAATCCG CCGCCGCCCT GCTTGCCTCC 901 GCCCTCTGCC TGACCGGCAT TTTCTCGCCCCTTGCCTCCC TCCTGCTGCC 951 GGAAAACTAC GCCGCCGTCC GGTTTATCGT CGTATCGTGTATGCTGCCGC 1001 CGCTGTTTTG CACGCTGGCG GAAATCAGCG GCATCGGTTT GAACGTCGTC1051 CGCAAAACGC GCCCGATCGC GCTCGCCACC TTGGGCGCGC TGGCGGCAAA 1101CCTGCTGCTG CTGGGGCTTG CCGTGCCGTC CGGCGGCGCG CGCGGCGCGG 1151 CGGTTGCCTGTGCCGCCTCA TTCTGGCTGT TTTTTGCCTT CAAGACCGAA 1201 AGCTCCTGCC GCCTGTGGCAGCCGCTCAAA CGCCTGCCGC TTTATCTGCA 1251 CACATTGTTC TGCCTGACCT CCTCGGCGGCCTACACCTGC TTCGGCACGC 1301 CGGCAAACTA TCCCCTGTTT GCCGGCGTAT GGGCGGCATATCTGGCAGGC 1351 TGCATCCTGC GCCACCGGAA AGATTTGCAC AAACTGTTTC ATTATTTGAA1401 AAAACAAGGT TTCCCATTAT GAThis corresponds to the amino acid sequence <SEQ ID 2416; ORF 717>:

m717.pep 1 MDTKEILGYA AGSIGSAVLA VIILPLLSWY FPADDIGRIV LMQTAAGLTV 51SVLCLGLDQA YVREYYATAD KDTLFKTLFL PPLLSAAAIA ALLLSRPSLP 101 SEILFSLDDAAAGIGLVLFE LSFLPIRFLL LVLRMEGRAL AFSSAQLVPK 151 LAILLLLPLT VGLLHFPANTAVLTAVYALA NLAAAAFLLF QNRCRLKAVR 201 HAPFSPAVLH RGLRYGIPIA LSSIAYWGLASADRLFLKKY AGLEQLGVYS 251 MGISFGGAAL LFQSIFSTVW TPYIFRAIEE NAPPARLSATAESAAALLAS 301 ALCLTGIFSP LASLLLPENY AAVRFIVVSC MLPPLFCTLA EISGIGLNVV351 RKTRPIALAT LGALAANLLL LGLAVPSGGA RGAAVACAAS FWLFFAFKTE 401SSCRLWQPLK RLPLYLHTLF CLTSSAAYTC FGTPANYPLF AGVWAAYLAG 451 CILRHRKDLHKLFHYLKKQG FPL* m717/g717 96.4% identity in 473 aa overlap        10        20        30        40        50        60 m717.pepMDTKEILGYAAGSIGSAVLAVIILPLLSWYFPADDIGRIVLMQTAAGLTVSVLCLGLDQA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g717MDTKEILGYAAGSIGSAVLAVIILPLLSWYFPADDIGRIVLMQTAAGLTVSVLCLGLDQA        10        20        30        40        50        60        70        80        90       100       110       120 m717.pepYVREYYATADKDTLFKTLFLPPLLSAAAIAALLLSRPSLPSEILFSLDDAAAGIGLVLFE|||||||:|||||||||||||||| :|||||||||||||||||||||||||||||||||| g717YVREYYAAADKDTLFKTLFLPPLLFSAAIAALLLSRPSLPSEILFSLDDAAAGIGLVLFE        70        80        90       100       110       120       130       140       150       160       170       180 m717.pepLSFLPIRFLLLVLRMEGRALAFSSAQLVPKLAILLLLPLTVGLLHFPANTAVLTAVYALA||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| g717LSFLPIRFLLLVLRMEGRALAFSSAQLVPKLAILLLLPLTVGLLHFPANTSVLTAVYALA       130       140       150       160       170       180       190       200       210       220       230       240 m717.pepNLAAAAFLLFQNRCRLKAVRHAPFSPAVLHRGLRYGIPIALSSIAYWGLASADRLFLKKY||||||||||||||||||||:|||||||||||||||||:||||:|||||||||||||||| g717NLAAAAFLLFQNRCRLKAVRRAPFSPAVLHRGLRYGIPLALSSLAYWGLASADRLFLKKY       190       200       210       220       230       240       250       260       270       280       290       300 m717.pepAGLEQLGVYSMGISFGGAALLFQSIFSTVWTPYIFRAIEENAPPARLSATAESAAALLAS|||||||||||||||||||||:|||||||||||||||||||| ||||||||||||||||| g717AGLEQLGVYSMGISFGGAALLLQSIFSTVWTPYIFRAIEENATPARLSATAESAAALLAS       250       260       270       280       290       300       310       320       330       340       350       360 m717.pepALCLTGIFSPLASLLLPENYAAVRFIVVSCMLPPLFCTLAEISGIGLNVVRKTRPIALAT||||||||||||||||||||||||| |||||||||| ||:|||||||||||||||||||| g717ALCLTGIFSPLASLLLPENYAAVRFTVVSCMLPPLFYLLTEISGIGLNVVRKTRPIALAT       310       320       330       340       350       360       370       380       390       400       410       420 m717.pepLGALAANLLLLGLAVPSGGARGAAVACAASFWLFFAFKTESSCRLWQPLKRLPLYLHTLF|||||||||||||||||||:|||||||||||||||:|||||||||||||||||||:|||| g717LGALAANLLLLGLAVPSGGTRGAAVACAASFWLFFVFKTESSCRLWQPLKRLPLYMHTLF       370       380       390       400       410       420       430       440       450       460       470 m717.pepCLTSSAAYTCFGTPANYPLFAGVKAAYLAGCILRHRKDLHKLFHYLKKQGFPLX||:||||||||||||||||||||||||||||||||||:|||||||||||||||| g717CLASSAAYTCFGTPANYPLFAGVKAAYLAGCILRHRKNLHKLFHYLKKQGFPLX       430       440       450       460       470The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2417>:

a717.seq 1 ATGGACACAA AAGAAATCCT CGGCTACGCG GCAGGCTCGA TCGGCAGCGC 51GGTTTTAGCC GTCATCATCC TGCCGCTGCT GTCGTGGTAT TTCCCTGCCG 101 ACGACATCGGACGCATCGTG CTGATGCAGA CGGCGGCGGG GCTGACGGTG 151 TCGGTGTTGT GCCTCGGGCTGGATCAGGCA TACGTCCGCG AATACTATGC 201 CGCCGCCGAC AAAGACACTT TGTTCAAAACCCTGTTCCTG CCGCCGCTGC 251 TGTCTGCCGC CGCGATAGCC GCCCTGCTGC TTTTCCGCGCATCCCTGCCG 301 TCTGAAATCC TGTTTTCGCT CGACGATGCC GCCGCCGGCA TCGGGCTGGT351 GCTGTTTGAA CTGAGCTTCC TGCCCATCCG CTTTCTCTTA CTGGTTTTGC 401GTATGGAAGG ACGCGCCCTT GCCTTTTCGT CCGCGCAACT CGTGTCCAAG 451 CTCGCCATCCTGCTGCTGCT GCCGCTGACG GTCGGGCTGC TGCACTTTCC 501 GGCGAACACC GCCGTCCTGACCGCCGTTTA CGCGCTGGCA AACCTTGCCG 551 CCGCCGCCTT TTTGCTGTTT CAAAACCGATGCCGTCTGAA GGCCGTCCGG 601 CGCGCACCGT TTTCATCCGC CGTCCTGCAT CGCGGCCTGCGCTACGGCAT 651 ACCGATCGCA CTAAGCAGCA TCGCCTATTG GGGGCTGGCA TCCGCCGACC701 GTTTGTTCCT GAAAAAATAT GCCGGCCTAG AACAGCTCGG CGTTTATTCG 751ATGGGTATTT CGTTCGGCGG AGCGGCATTA TTGTTCCAAA GCATCTTTTC 801 AACGGTCTGGACACCGTATA TTTTCCGCGC AATCGAAGCA AACGCCCCGC 851 CCGCCCGCCT CTCGGCAACGGCAGAATCCG CCGCCGCCTT GCTTGCCTCC 901 GCCCTCTGCC TGACCGGCAT TTTCTCGCCCCTCGCCTCCC TCCTGCTGCC 951 GGAAAACTAC GCCGCCGTCC GGTTTATCGT CGTATCGTGTATGCTGCCTC 1001 CGCTGTTTTG CACGCTGGTA GAAATCAGCG GCATCGGTTT GAACGTCGTC1051 CGAAAAACAC GCCCGATCGC GCTCGCCACC TTGGGCGCGC TGGCGGCAAA 1101CCTGCTGCTG CTGGGGCTTG CCGTACCGTC CGGCGGCGCG CGCGGCGCGG 1151 CGGTTGCCTGTGCCGCCTCA TTTTGGCTGT TTTTTGTTTT CAAGACCGAA 1201 AGCTCCTGCC GCCTGTGGCAGCCGCTCAAA CGCCTGCCGC TTTATATGCA 1251 CACATTGTTC TGCCTGGCCT CCTCGGCGGCCTACACCTGC TTCGGCACTC 1301 CGGCAAACTA CCCCCTGTTT GCCGGCGTAT GGGCGGTATATCTGGCAGGC 1351 TGCATCCTGC GCCACCGGAA AGATTTGCAC AAACTGTTTC ATTATTTGAA1401 AAAACAAGGT TTCCCATTAT GAThis corresponds to the amino acid sequence <SEQ ID 2418; ORF 717.a>:

a717.pep 1 MDTKEILGYA AGSIGSAVLA VIILPLLSWY FPADDIGRIV LMQTAAGLTV 51SVLCLGLDQA YVREYYAAAD KDTLFKTLFL PPLLSAAAIA ALLLSRPSLP 101 SEILFSLDDAAAGIGLVLFE LSFLPIRFLL LVLRMEGRAL AFSSAQLVSK 151 LAILLLLPLT VGLLHFPANTAVLTAVYALA NLAAAAFLLF QNRCRLKAVR 201 RAPFSSAVLH RGLRYGIPIA LSSIAYWGLASADRLFLKKY AGLEQLGVYS 251 MGISFGGAAL LFQSIFSTVW TPYIFRAIEA NAPPARLSATAESAAALLAS 301 ALCLTGIFSP LASLLLPENY AAVRFIVVSC MLPPLFCTLV EISGIGLNVV351 RKTRPIALAT LGALAANLLL LGLAVPSGGA RGAAVACAAS FWLFFVFKTE 401SSCRLWQPLK RLPLYMHTLF CLASSAAYTC FGTPANYPLF AGVWAVYLAG 451 CILRHRKDLHKLFHYLKKQG FPL* a717/m717 97.9% identity in 473 aa overlap        10        20        30        40        50        60 a717.pepMDTKEILGYAAGSIGSAVLAVIILPLLSWYFPADDIGRIVLMQTAAGLTVSVLCLGLDQA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m717MDTKEILGYAAGSIGSAVLAVIILPLLSWYFPADDIGRIVLMQTAAGLTVSVLCLGLDQA        10        20        30        40        50        60        70        80        90       100       110       120 a717.pepYVREYYAAADKDTLFKTLFLPPLLSAAAIAALLLSRPSLPSEILFSLDDAAAGIGLVLFE|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||| m717YVREYYATADKDTLFKTLFLPPLLSAAAIAALLLSRPSLPSEILFSLDDAAAGIGLVLFE        70        80        90       100       110       120       130       140       150       160       170       180 a717.pepLSFLPIRFLLLVLRMEGRALAFSSAQLVSKLAILLLLPLTVGLLHFPANTAVLTAVYALA|||||||||||||||||||||||||||| ||||||||||||||||||||||||||||||| m717LSFLPIRFLLLVLRMEGRALAFSSAQLVPKLAILLLLPLTVGLLHFPANTAVLTAVYALA       130       140       150       160       170       180       190       200       210       220       230       240 a717.pepNLAAAAFLLFQNRCRLKAVRRAPFSSAVLHRGLRYGIPIALSSIAYWGLASADRLFLKKY||||||||||||||||||||:|||| |||||||||||||||||||||||||||||||||| m717NLAAAAFLLFQNRCRLKAVRHAPFSPAVLHRGLRYGIPIALSSIAYWGLASADRLFLKKY       190       200       210       220       230       240       250       260       270       280       290       300 a717.pepAGLEQLGVYSMGISFGGAALLFQSIFSTVWTPYIFRAIEANAPPARLSATAESAAALLAS||||||||||||||||||||||||||||||||||||||| |||||||||||||||||||| m717AGLEQLGVYSMGISFGGAALLFQSIFSTVWTPYIFRAIEENAPPARLSATAESAAALLAS       250       260       270       280       290       300       310       320       330       340       350       360 a717.pepALCLTGIFSPLASLLLPENYAAVRFIVVSCMLPPLFCTLVEISGIGLNVVRKTRPIALAT|||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||| m717ALCLTGIFSPLASLLLPENYAAVRFIVVSCMLPPLFCTLAEISGIGLNVVRKTRPIALAT       310       320       330       340       350       360       370       380       390       400       410       420 a717.pepLGALAANLLLLGLAVPSGGARGAAVACAASFWLFFVFKTESSCRLWQPLKRLPLYMHTLF|||||||||||||||||||||||||||||||||||:|||||||||||||||||||:|||| m717LGALAANLLLLGLAVPSGGARGAAVACAASFWLFFAFKTESSCRLWQPLKRLPLYLHTLF       370       380       390       400       410       420       430       440       450       460       470 a717.pepCLASSAAYTCFGTPANYPLFAGVWAVYLAGCILRHRKDLHKLFHYLKKQGFPLX||:||||||||||||||||||||||:|||||||||||||||||||||||||||| m717CLTSSAAYTCFGTPANYPLFAGVWAAYLAGCILRHRKDLHKLFHYLKKQGFPLX       430       440       450       460       470

g718.seq not found yet

g718.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2419>:

m718.seq 1 TCAGACGGCC TTTACGTACC CCGAAACTTT ATCCACCGCC CGCAAAGCTG 51GTTCAAATGG GACAAAGACA ACGGGCTGCT GCTGCGTACC CGCGAAAATC 101 CGGAAGGCGAAGCGTTGTGG CCGCTGGGCT GGGTCGTTCA TACCCAAAAA 151 TCGCGCAGCG TCCAGCAGGCGCGCAACGGG CTTTTCCGCA CGCTTTCCTG 201 GCTGTATATG TTCAAACACT ACGCCGTCCACGATTTTGCC GAGTTTTTGG 251 AGCTGTACGG CATGCCCATC CGTATCGGCA AATACGGCGCGGGCGCAACC 301 AAAGAGGAAA AAAACACCCT GCTTCGAGCG GTGGCGGAAA TCGGTCACAA351 CGCGGCAGGC ATCATGCCAG AAGGTATGGA AATAGAGCTC CACAACGCGG 401CAAACGGTAC GACGGCAACC AGCAATCCGT TTTTGCAGAT GGCCGACTGG 451 TGCGAAAAATCGGCGGCGCG GCTGATTTTG GGGCAAACGC TGACCAGCGG 501 TGCGGACGGA AAATCCAGCACCAACGCGCT GGGCAATATC CACAACGAGG 551 TACGCCGCGA TTTGCTGGTG TCGGACGCAAAACAGGTGGC GCAAACCATC 601 ACAAGCCAAA TCATCGGACC GTTCCTGCAA ATCAACTATCCCCATGCCGA 651 CCCAAACCGC GTGCCGAAAT TTGAATTTGA CACGCGCGAG CCGAAAGACA701 TCGCGGTCTT TGCCGACGCT ATCCCGAAAC TGGTGGATGT CGGCGTACAA 751ATCCCCGAAA GCTGGGTGCG CGACAAACTG GTCATTCCAG ATGTGCAGGA 801 GGGTGAGGCTGTGTTGGTGC GGCAGGTACC GGACAATCCG GTAAACAGAA 851 CTGCATTGGC GGCTTTATCCGCCCACACCG TACCATCTAA GGCTACGGGC 901 AGGCATCAGG AAATATTGGA CGGCGCGTTGGATGACGCGC TGGTTGAGCC 951 CGATTTCAAT TCTCAGCTCA ACCCGATGGT GCGTCAGGCGGTTGCCGCAC 1001 TTAATGCTTG CAACAGCTAC GAGGAGGCAG ATGCCGCACT GAATGCGCTT1051 TATCCGAATT TGGACAACGC GAAACTGCGT ACCTATATGC AGCAGGCCTT 1101GTTTATCAGC GATATTTTGG GACAAGACCA TGCCCGCGCC TGAThis corresponds to the amino acid sequence <SEQ ID 2420; ORF 718>:

m718.pep 1 SDGLYVPRNF IHRPQSWFKW DKDNGLLLRT RENPEGEALW PLGWVVHTQK 51SRSVQQARNG LFRTLSWLYM FKHYAVHDFA EFLELYGMPI RIGKYGAGAT 101 KEEKNTLLRAVAEIGHNAAG IMPEGMEIEL HNAANGTTAT SNPFLQMADW 151 CEKSAARLIL GQTLTSGADGKSSTNALGNI HNEVRRDLLV SDAKQVAQTI 201 TSQIIGPFLQ INYPHADPNR VPKFEFDTREPKDIAVFADA IPKLVDVGVQ 251 IPESWVRDKL VIPDVQEGEA VLVRQVPDNP VNRTALAALSAHTVPSKATG 301 RHQEILDGAL DDALVEPDFN SQLNPMVRQA VAALNACNSY EEADAALNAL351 YPNLDNAKLR TYMQQALFIS DILGQDHARA *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2421>:

a718.seq 1 ATGGAGCCGA TAATGGCAAA AAAGAACAAT AAAACTAAAA TCCAAAAGCC 51CGAAGCTGCA TTGCAGACGG ACGTGGCTCA AATTACAGCG ACCGGTCGAG 101 TTATCGCCGAGCATCCATCC AATTTTATTA CGCCGCAAAA GATGCGCGCC 151 CTCTTCGAGG ACGCAGAAAGCGGTGACATC CGCGCCCAAC ACGAGCTTTT 201 CGCGGACATT GAGGAGCGCG ACAGCGACATCGCGGCAAAT ATGGGGACGC 251 GCAAACGCGC GCTGCTGACG CTCAACTGGC GCGTCGCCCCGCCGCGAAAT 301 GCGACGCCCG AAGAAGAAAA GCTGTCCGAC CAAGCCTACG AAATGATGGA351 CAGCCTGCCT ACCCTCGAAG ACCTGATTAT GGATTTGATG GACGCGGTAG 401GGCACGGATT TTCTGCGTTG GAGGTCGAGT GGGTATTTTC AGACGGCCTT 451 TACCTACCCCGAAACTTTAT CCACCGCCCG CAAAGCTGGT TCAAATGGGA 501 CAAAGACAAC GGGCTGCTGCTGCGTACCCG CGAAAATCCG GAAGGCGAAG 551 CGTTGTGGCC GCTGGGCTGG GTCGTTCATACCCAAAAATC GCGCAGCGTC 601 CAGCAGGCGC GCAACGGGCT TTTCCGCACG CTTTCCTGGCTGTATATGTT 651 CAAACACTAC GCCGTCCACG ATTTTGCCGA GTTTTTGGAG CTGTACGGCA701 TGCCCATCCG TATCGGCAAA TACGGCGCGG GCGCAACCAA AGAGGAAAAA 751AACACCCTGC TTCGAGCGGT GGCGGAAATC GGTCACAACG CGGCAGGCAT 801 CATGCCAGAAGGTATGGAAA TCGAGCTGCA CAACGCGGCA AACGGCATGA 851 CTTCCGCCGG CAATCCGTTTTTGCAGATGG CCGACTGGTG CGAAAAATCG 901 GCGGCGCGGC TGATTTTGGG GCAAACGCTAACCAGCGGTG CGGACGGAAA 951 ATCCAGCACC AACGCGCTGG GCAATATCCA CAACGAGATACGCCGCGATT 1001 TGCTGGTGTC GGACGCAAAA CAGGTGGCGC AAACCATCAC AAGCCAAATC1051 ATCGGACCGT TCCTGCAAAT CAACTATCCC CATGCCGACC CAAACCGCGT 1101GCCGAAATTT GAATTTGACA CGCGCGAGCC GAAAGACATC GCGGTCTTTG 1151 CCGACGCTATCCCGAAACTG GTGGATGTCG GCGTACAAAT CCCCGAAAGC 1201 TGGGTGCGCG ACAAACTGGTCATTCCAGAT GTGCAGGAGG GTGAGGCTGT 1251 GTTGGTGCGG CAGGTACCGG ACAATCCGGTAAACAGAACT GCATTGGCGG 1301 CTTTATCCGC CCACACCGTA CCATCTAAGG CTACGGGCAGGCATCAGGAA 1351 ATATTGGACG GCGCGTTGGA TGACGCGCTG GTTGAGCCCG ATTTCAATTC1401 TCAGCTCAAC CCGATGGTGC GTCAGGCGGT TGCCGCACTT AATGCTTGCA 1451ACAGCTACGA GGAGGCAGAT GCCGCACTGA ATGCGCTTTA TCCGAATTTG 1501 GACAACGCGAAACTGCGTAC CTATATGCAG CAGGCCTTGT TTATCAGCGA 1551 TATTTTGGGA CAAGACCATGCCCGCGCCTG AThis corresponds to the amino acid sequence <SEQ ID 2422; ORF 718.a>:

a718.pep 1 MEPIMAKKNN KTKIQKPEAA LQTDVAQITA TGRVIAEHPS NFITPQKMRA 51LFEDAESGDI RAQHELFADI EERDSDIAAN MGTRKRALLT LNWRVAPPRN 101 ATPEEEKLSDQAYEMMDSLP TLEDLIMDLM DAVGHGFSAL EVEWVFSDGL 151 YLPRNFIHRP QSWFKWDKDNGLLLRTRENP EGEALWPLGW VVHTQKSRSV 201 QQARNGLFRT LSWLYMFKHY AVHDFAEFLELYGMPIRIGK YGAGATKEEK 251 NTLLRAVAEI GHNAAGIMPE GMEIELHNAA NGMTSAGNPFLQMADWCEKS 301 AARLILGQTL TSGADGKSST NALGNIHNEI RRDLLVSDAK QVAQTITSQI351 IGPFLQINYP HADPNRVPKF EFDTREPKDI AVFADAIPKL VDVGVQIPES 401WVRDKLVIPD VQEGEAVLVR QVPDNPVNRT ALAALSAHTV PSKATGRHQE 451 ILDGALDDALVEPDFNSQLN PMVRQAVAAL NACNSYEEAD AALNALYPNL 501 DNAKLRTYMQ QALFISDILGQDHARA* a718/m718 98.4% identity in 380 aa overlap 120       130       140       150       160       170 a718.pepDSLPTLEDLIMDLMDAVGHGFSALEVEWVFSDGLYLPRNFIHRPQSWFKWDKDNGLLLRT                              |||||:|||||||||||||||||||||||| m718                              SDGLYVPRNFIHRPQSWFKWDKDNGLLLRT                                      10        20        30 180       190       200       210       220       230 a718.pepRENPEGEALWPLGWVVHTQKSRSVQQARNGLFRTLSWLYMFKHYAVHDFAEFLELYGMPI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m718RENPEGEALWPLGWVVHIQKSRSVQQARNGLFRTLSWLYMFKHYAVHDFAEFLELYGMPI        40        50        60        70        80        90 240       250       260       270       280       290 a718.pepRIGKYGAGATKEEKNTLLRAVAEIGHNAAGIMPEGMEIELHNAANGMTSAGNPFLQMADW|||||||||||||||||||||||||||||||||||||||||||||| |:::||||||||| m718RIGKYGAGATKEEKNTLLRAVAEIGHNAAGIMPEGMEIELHNAANGTTATSNPFLQMADW       100       110       120       130       140       150 300       310       320       330       340       350 a718.pepCEKSAARLILGQTLTSGADGKSSTNALGNIHNEIRRDLLVSDAKQVAQTITSQIIGPFLQ|||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||| m718CEKSAARLILGQTLTSGADGKSSTNALGNIHNEVRRDLLVSDAKQVAQTITSQIIGPFLQ       160       170       180       190       200       210 360       370       380       390       400       410 a718.pepINYPHADPNRVPKFEFDTREPKDIAVFADAIPKLVDVGVQIPESWVRDKLVIPDVQEGEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m718INYPHADPNRVPKFEFDTREPKDIAVFADAIPKLVDVGVQIPESWVRDKLVIPDVQEGEA       220       230       240       250       260       270 420       430       440       450       460       470 a718.pepVLVRQVPDNPVNRTALAALSAHTVPSKATGRHQEILDGALDDALVEPDFNSQLNPMVRQA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m718VLVRQVPDNPVNRTALAALSAHTVPSKATGRHQEILDGALDDALVEPDFNSQLNPMVRQA       280       290       300       310       320       330 480       490       500       510       520 a718.pepVAALNACNSYEEADAALNALYPNLDNAKLRTYMQQALFISDILGQDHARAX||||||||||||||||||||||||||||||||||||||||||||||||||| m718VAALNACNSYEEADAALNALYPNLDNAKLRTYMQQALFISDILGQDHARAX       340       350       360       370       380The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2423>:

m718-1.seq 1 ATGGAGCCGA TAATGGCAAA AAAGAACAAT AAAACTAAAA TCCAAAAGCC 51CGAAGCTGCA TTGCAGACGG ACGTGGCTCA AATTACGGCG ACCGGTCGGG 101 TTATCGCCGAGCATCCGTCC AATTTTATTA CGCCGCAAAA GATGCGGGCC 151 CTCTTCGAGG ACGCAGAAAGCGGCGACATC CGCGCCCAAC ACGAGCTTTT 201 CGCGGACATT GAGGAGCGCG ACAGCGACATCGCGGCAAAT ATGGGGACGC 251 GCAAACGCGC GCTGCTGACG CTCAACTGGC GCGTCGCCCCGCCGCGAAAT 301 GCGACGCCCG AAGAAGAAAA GCTGTCCGAC CAAGCCTACG AAATGATGGA351 CAGCCTGCCT ACCCTCGAAG ACCTGATTAT GGATTTGATG GACGCGGTAG 401GGCACGGATT TTCTGCGTTG GAGGTCGAGT GGGTATTTTC AGACGGCCTT 451 TACCTACCCCGAAACTTTAT CCACCGCCCG CAAAGCTGGT TCAAATGGGA 501 CAAAGACAAC GGGCTGCTGCTGCGTACCCG CGAAAATCCG GAAGGCGAAG 551 CGTTGTGGCC GCTGGGCTGG GTCGTTCATACCCAAAAATC GCGCAGCGTC 601 CAGCAGGCGC GCAACGGGCT TTTCCGCACG CTTTCCTGGCTGTATATGTT 651 CAAACACTAC GCCGTCCACG ATTTTGCCGA GTTTTTGGAG CTGTACGGCA701 TGCCCATCCG TATCGGCAAA TACGGCGCGG GCGCAACCAA AGAGGAAAAA 751AACACCCTGC TTCGAGCGGT GGCGGAAATC GGTCACAACG CGGCAGGCAT 801 CATGCCAGAAGGTATGGAAA TAGAGCTCCA CAACGCGGCA AACGGTACGA 851 CGGCAACCAG CAATCCGTTTTTGCAGATGG CCGACTGGTG CGAAAAATCG 901 GCGGCGCGGC TGATTTTGGG GCAAACGCTGACCAGCGGTG CGGACGGAAA 951 ATCCAGCACC AACGCGCTGG GCAATATCCA CAACGAGGTACGCCGCGATT 1001 TGCTGGTGTC GGACGCAAAA CAGGTGGCGC AAACCATCAC AAGCCAAATC1051 ATCGGACCGT TCCTGCAAAT CAACTATCCC CATGCCGACC CAAACCGCGT 1101GCCGAAATTT GAATTTGACA CGCGCGAGCC GAAAGACATC GCGGTCTTTG 1151 CCGACGCTATCCCGAAACTG GTGGATGTCG GCGTACAAAT CCCCGAAAGC 1201 TGGGTGCGCG ACAAACTGGTCATTCCAGAT GTGCAGGAGG GTGAGGCTGT 1251 GTTGGTGCGG CAGGTACCGG ACAATCCGGTAAACAGAACT GCATTGGCGG 1301 CTTTATCCGC CCACACCGTA CCATCTAAGG CTACGGGCAGGCATCAGGAA 1351 ATATTGGACG GCGCGTTGGA TGACGCGCTG GTTGAGCCCG ATTTCAATTC1401 TCAGCTCAAC CCGATGGTGC GTCAGGCGGT TGCCGCACTT AATGCTTGCA 1451ACAGCTACGA GGAGGCAGAT GCCGCACTGA ATGCGCTTTA TCCGAATTTG 1501 GACAACGCGAAACTGCGTAC CTATATGCAG CAGGCCTTGT TTATCAGCGA 1551 TATTTTGGGA CAAGACCATGCCCGCGCCTG AThis corresponds to the amino acid sequence <SEQ ID 2424; ORF 718-1>:

m718-1.pep. 1 MEPIMAKKNN KTKIQKPEAA LQTDVAQITA TGRVIAEHPS NFITPQKMRA 51LFEDAESGDI RAQHELFADI EERDSDIAAN MGTRKRALLT LNWRVAPPRN 101 ATPEEEKLSDQAYEMMDSLP TLEDLIMDLM DAVGHGFSAL EVEWVFSDGL 151 YLPRNFIHRP QSWFKWDKDNGLLLRTRENP EGEALWPLGW VVHTQKSRSV 201 QQARNGLFRT LSWLYMFKHY AVHDFAEFLELYGMPIRIGK YGAGATKEEK 251 NTLLRAVAEI GHNAAGIMPE GMEIELHNAA NGTTATSNPFLQMADWCEKS 301 AARLILGQTL TSGADGKSST NALGNIHNEV RRDLLVSDAK QVAQTITSQI351 IGPFLQINYP HADPNRVPKF EFDTREPKDI AVFADAIPKL VDVGVQIPES 401WVRDKLVIPD VQEGEAVLVR QVPDNPVNRT ALAALSAHTV PSKATGRHQE 451 ILDGALDDALVEPDFNSQLN PMVRQAVAAL NACNSYEEAD AALNALYPNL 501 DNAKLRTYMQ QALFISDILGQDHARA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2425>:

a718.seq 1 ATGGAGCCGA TAATGGCAAA AAAGAACAAT AAAACTAAAA TCCAAAAGCC 51CGAAGCTGCA TTGCAGACGG ACGTGGCTCA AATTACAGCG ACCGGTCGAG 101 TTATCGCCGAGCATCCATCC AATTTTATTA CGCCGCAAAA GATGCGCGCC 151 CTCTTCGAGG ACGCAGAAAGCGGTGACATC CGCGCCCAAC ACGAGCTTTT 201 CGCGGACATT GAGGAGCGCG ACAGCGACATCGCGGCAAAT ATGGGGACGC 251 GCAAACGCGC GCTGCTGACG CTCAACTGGC GCGTCGCCCCGCCGCGAAAT 301 GCGACGCCCG AAGAAGAAAA GCTGTCCGAC CAAGCCTACG AAATGATGGA351 CAGCCTGCCT ACCCTCGAAG ACCTGATTAT GGATTTGATG GACGCGGTAG 401GGCACGGATT TTCTGCGTTG GAGGTCGAGT GGGTATTTTC AGACGGCCTT 451 TACCTACCCCGAAACTTTAT CCACCGCCCG CAAAGCTGGT TCAAATGGGA 501 CAAAGACAAC GGGCTGCTGCTGCGTACCCG CGAAAATCCG GAAGGCGAAG 551 CGTTGTGGCC GCTGGGCTGG GTCGTTCATACCCAAAAATC GCGCAGCGTC 601 CAGCAGGCGC GCAACGGGCT TTTCCGCACG CTTTCCTGGCTGTATATGTT 651 CAAACACTAC GCCGTCCACG ATTTTGCCGA GTTTTTGGAG CTGTACGGCA701 TGCCCATCCG TATCGGCAAA TACGGCGCGG GCGCAACCAA AGAGGAAAAA 751AACACCCTGC TTCGAGCGGT GGCGGAAATC GGTCACAACG CGGCAGGCAT 801 CATGCCAGAAGGTATGGAAA TCGAGCTGCA CAACGCGGCA AACGGCATGA 851 CTTCCGCCGG CAATCCGTTTTTGCAGATGG CCGACTGGTG CGAAAAATCG 901 GCGGCGCGGC TGATTTTGGG GCAAACGCTAACCAGCGGTG CGGACGGAAA 951 ATCCAGCACC AACGCGCTGG GCAATATCCA CAACGAGATACGCCGCGATT 1001 TGCTGGTGTC GGACGCAAAA CAGGTGGCGC AAACCATCAC AAGCCAAATC1051 ATCGGACCGT TCCTGCAAAT CAACTATCCC CATGCCGACC CAAACCGCGT 1101GCCGAAATTT GAATTTGACA CGCGCGAGCC GAAAGACATC GCGGTCTTTG 1151 CCGACGCTATCCCGAAACTG GTGGATGTCG GCGTACAAAT CCCCGAAAGC 1201 TGGGTGCGCG ACAAACTGGTCATTCCAGAT GTGCAGGAGG GTGAGGCTGT 1251 GTTGGTGCGG CAGGTACCGG ACAATCCGGTAAACAGAACT GCATTGGCGG 1301 CTTTATCCGC CCACACCGTA CCATCTAAGG CTACGGGCAGGCATCAGGAA 1351 ATATTGGACG GCGCGTTGGA TGACGCGCTG GTTGAGCCCG ATTTCAATTC1401 TCAGCTCAAC CCGATGGTGC GTCAGGCGGT TGCCGCACTT AATGCTTGCA 1451ACAGCTACGA GGAGGCAGAT GCCGCACTGA ATGCGCTTTA TCCGAATTTG 1501 GACAACGCGAAACTGCGTAC CTATATGCAG CAGGCCTTGT TTATCAGCGA 1551 TATTTTGGGA CAAGACCATGCCCGCGCCTG AThis corresponds to the amino acid sequence <SEQ ID 2426; ORF 718-1.a>:

a718.pep 1 MEPIMAKKNN KTKIQKPEAA LQTDVAQITA TGRVIAEHPS NFITPQKMRA 51LFEDAESGDI RAQHELFADI EERDSDIAAN MGTRKRALLT LNWRVAPPRN 101 ATPEEEKLSDQAYEMMDSLP TLEDLIMDLM DAVGHGFSAL EVEWVFSDGL 151 YLPRNFIHRP QSWFKWDKDNGLLLRTRENP EGEALWPLGW VVHTQKSRSV 201 QQARNGLFRT LSWLYMFKHY AVHDFAEFLELYGMPIRIGK YGAGATKEEK 251 NTLLRAVAEI GHNAAGIMPE GMEIELHNAA NGMTSAGNPFLQMADWCEKS 301 AARLILGQTL TSGADGKSST NALGNIHNEI RRDLLVSDAK QVAQTITSQI351 IGPFLQINYP HADPNRVPKF EFDTREPKDI AVFADAIPKL VDVGVQIPES 401WVRDKLVIPD VQEGEAVLVR QVPDNPVNRT ALAALSAHTV PSKATGRHQE 451 ILDGALDDALVEPDFNSQLN PMVRQAVAAL NACNSYEEAD AALNALYPNL 501 DNAKLRTYMQ QALFISDILGQDHARA* a718/m718-1 99.0% identity in 526 aa overlap        10        20        30        40        50        60 a718.pepMEPIMAKKNNKTKIQKPEAALQTDVAQITATGRVIAEHPSNFITPQKMRALFEDAESGDI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m718-1MEPIMAKKNNKTKIQKPEAALQTDVAQITATGRVIAEHPSNFITPQKMRALFEDAESGDI        10        20        30        40        50        60        70        80        90       100       110       120 a718.pepRAQHELFADIEERDSDIAANMGTRKRALLTLNWRVAPPRNATPEEEKLSDQAYEMMDSLP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m718-1RAQHELFADIEERDSDIAANMGTRKRALLTLNWRVAPPRNATPEEEKLSDQAYEMMDSLP        70        80        90       100       110       120       130       140       150       160       170       180 a718.pepTLEDLIMDLMDAVGHGFSALEVEWVFSDGLYLPRNFIHRPQSWFKWDKDNGLLLRTRENP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m718-1TLEDLIMDLMDAVGHGFSALEVEWVFSDGLYLPRNFIHRPQSWFKWDKDNGLLLRTRENP       130       140       150       160       170       180       190       200       210       220       230       240 a718.pepEGEALWPLGWVVHTQKSRSVQQARNGLFRTLSWLYMFKHYAVHDFAEFLELYGMPIRIGK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m718-1EGEALWPLGWVVHTQKSRSVQQARNGLFRTLSWLYMFKHYAVHDFAEFLELYGMPIRIGK       190       200       210       220       230       240       250       260       270       280       290       300 a718.pepYGAGATKEEKNTLLRAVAEIGHNAAGIMPEGMEIELHNAANGMTSAGNPFLQMADWCEKS|||||||||||||||||||||||||||||||||||||||||| |:::||||||||||||| m718-1YGAGATKEEKNTLLRAVAEIGHNAAGIMPEGMEIELHNAANGTTATSNPFLQMADWCEKS       250       260       270       280       290       300       310       320       330       340       350       360 a718.pepAARLILGQTLTSGADGKSSTNALGNIHNEIRRDLLVSDAKQVAQTITSQIIGPFLQINYP|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| m718-1AARLILGQTLTSGADGKSSTNALGNIHNEVRRDLLVSDAKQVAQTITSQIIGPFLQINYP       310       320       330       340       350       360       370       380       390       400       410       420 a718.pepHADPNRVPKFEFDTREPKDIAVFADAIPKLVDVGVQIPESWVRDKLVIPDVQEGEAVLVR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m718-1HADPNRVPKFEFDTREPKDIAVFADAIPKLVDVGVQIPESWVRDKLVIPDVQEGEAVLVR       370       380       390       400       410       420       430       440       450       460       470       480 a718.pepQVPDNPVNRTALAALSAHTVPSKATGRHQEILDGALDDALVEPDFNSQLNPMVRQAVAAL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m718-1QVPDNPVNRTALAALSAHTVPSKATGRHQEILDGALDDALVEPDFNSQLNPMVRQAVAAL       430       440       450       460       470       480       490       500       510       520 a718.pepNACNSYEEADAALNALYPNLDNAKLRTYMQQALFISDILGQDHARAX||||||||||||||||||||||||||||||||||||||||||||||| m718-1NACNSYEEADAALNALYPNLDNAKLRTYMQQALFISDILGQDHARAX       490       500       510       520

g719.seq not found yet

g719.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2427>:

m719.seq 1 ATGGCAAACG GGAACATGAA ACTGTCGTTG GTGTTAACCG CCCGAGATGA 51CGGAGCGAGA CGGCTACTGG CTGATACTCA ACGACAATTA GATCGTACCG 101 CGAAATCGCGGGCGCAACTT GAACGGCAAA GCCATACTTA TGCGTTGACC 151 GGCATCCGCT CAGAAAAACAGATTCAACGC GAAATCATGC TGACACAGGC 201 TGCGTTTAAC CGTTTGGCGC GCAGCGGCAAGGCATCACAA AATGATTTGG 251 CACGGGCGGC GGTCGCTACG CGTAACCGAA TTCGCGAGCTGAACGCGGAA 301 CTGAAACAGG GCACGGGATT TGCGGACAAG ATGGGAAAAA TCGGAAGATT351 CGGTGCAGCT GCGGTGGCTG GTGGCGCGGC AGCGTATACG GTGCTTAAGC 401CTGCTATGGA CAACAGAAAG CAGCTTGATG AGAACATCAA CCGCGTGTCC 451 AGACAGGCATTTATTGAGGA TAACAGTAAA TCGGCAGCGT GGATTGCAAC 501 TGAAGGTGCG CAACAGATCAAGGATTTGGC ACTTGAACTT GTCGAGAAAA 551 ATGGCGGGAC CCACGATAAG GCTTTGGATTTAATCAGCGG CATGATGACC 601 ACCGGTCTGA ATTTTGCCCA AACCAAGAAT GAAGCGCAGGCGGCATATGC 651 TTTTGCACTT GCCTCAGAAG GCAGTGGCGA GGATACGGCA AAACTGATTA701 AAACCCTGAA AGATGGCGGC ATGAGCGGTA AAGACCTGCA ACTCGGGCTT 751GAGCACGTCT TGCAATCGGG TTTAGACGGC ACTTTCGAGG TGCGGGATAT 801 GGTTCGGGAGCTGCCGAGCC TGCTCTCTGC CGCGCAACAG GCAGGGATGA 851 ATGGTGTCGG CGGTTTGGACTACCTGCTCT CACTCTTACA ATCTGCGGCG 901 AATAAATCGG GCAGTCCTGC CGAAGCGGCGACTAATGTGC AAAATCTTTT 951 GAGTAAAACT CTGTCGCCTG ACACGATAGG TCGTCTGAAGAAGATGGCAA 1001 ATCCGAATGA CCCGAAGAAA GGTGTCGATT GGATAGGCTC GGTTGTGCAA1051 GGCAAGCAAA ACGGCGAAAA CGCAGTGCAG GTGTTGTCCC GTCTTGCCGA 1101TGCCATGCTA GTAAAGGATA AGCAATACCA AGATTATAAG AAACGCGCGG 1151 CTGCAGGCGATAAGACGGCG GCGGAGCAGG CAAATATGCT TAAGGGCGCG 1201 CTTTTGGCGC AACTGCTGCCTGATTTGCAG GCAAAACAAG GTTTGCTGGC 1251 TGCAACGGAT ATGACGCAAA TCCGTGAATATATGGCTTCG TTGGCTGGCG 1301 TAACGTTGGA TAACGGAAAA ATTGCTAAGA ACAACGAGGCGCGAATGTTG 1351 TCGGCAGCGG CGCAACAAGA GCAACAGGAA TCGCTGGCAA TGTTGCGGGA1401 AAGTCTGACG GGAACATTGG TGGATATGGA AACCTCGTTT AAAAAGCTGG 1451CAGCGGAATA CCCTAATGCC ACTCTAGCCC TGCAAGCATT GACGACGGCG 1501 GCAACAGCGGCGTCTGCCGC AATGTTATTA ACCGCCGGTG GCGGTAAAGG 1551 TGCAGGCTTT CTGAAAGATGTAGGTAGTAA AGCGTTGGGA TGGGGTAAGG 1601 CTTCCGCAGG CGGCGTGGCA GCAGGTGCCACAGCGGCAGG CGGTAAGTTG 1651 CTGTCATGGG GAAAATCTGC CGGTAGCGGG CTCATGAATAATCCAGCGTT 1701 AGTTAAACGG GCGGGTTTGT TAGGTATGTT GCTGTATTCC GAGTCTTTGG1751 GTGACGGCAC ATTGCCAAAG GGTTTGCGTG GTACCAAGAC AACTCCTGAA 1801ATGATTAATC GTCTGAAAAA CAACGGTATC CGATTTGAAC CTGCGCCGAA 1851 GCGGGAACAGGCGCGGGGTG GTGTCCCTCA GTATTTGGCT GCTCCGTCAG 1901 CGCAGCCTAC CGATAAGATGTTGTCTCCGT TGTTTTCAAC TCAGACGGCG 1951 GCGTATCAGG CAGCCATTCA GCAGCAGACGGCGGCGTATC AGGCAGCATT 2001 GGCGCAGGAT ACGGCTGCAG TTACAACAGG TTTGGCACAAGTGCAAAGTG 2051 CGATGGCGTC GGCAAGTCAG ACCATCAATA CCAATGTGAG CCTGAATATC2101 GACGGACGTG TTATCGCGAA TGAGGTATCG CGGTATCAAG TGGCCATGTT 2151CGGCCGTGGA GCGGGTCAAT AAThis corresponds to the amino acid sequence <SEQ ID 2428; ORF 719>:

m719.pep 1 MANGNMKLSL VLTARDDGAR RLLADTQRQL DRTAKSRAQL ERQSHTYALT 51GIRSEKQIQR EIMLTQAAFN RLARSGKASQ NDLARAAVAT RNRIRELNAE 101 LKQGTGFADKMGKIGRFGAA AVAGGAAAYT VLKPAMDNRK QLDENINRVS 151 RQAFIEDNSK SAAWIATEGAQQIKDLALEL VEKNGGTHDK ALDLISGMMT 201 TGLNFAQTKN EAQAAYAFAL ASEGSGEDTAKLIKTLKDGG MSGKDLQLGL 251 EHVLQSGLDG TFEVRDMVRE LPSLLSAAQQ AGMNGVGGLDYLLSLLQSAA 301 NKSGSPAEAA TNVQNLLSKT LSPDTIGRLK KMANPNDPKK GVDWIGSVVQ351 GKQNGENAVQ VLSRLADAML VKDKQYQDYK KRAAAGDKTA AEQANMLKGA 401LLAQLLPDLQ AKQGLLAATD MTQIREYMAS LAGVTLDNGK IAKNNEARML 451 SAAAQQEQQESLAMLRESLT GTLVDMETSF KKLAAEYPNA TLALQALTTA 501 ATAASAAMLL TAGGGKGAGFLKDVGSKALG WGKASAGGVA AGATAAGGKL 551 LSWGKSAGSG LMNNPALVKR AGLLGMLLYSESLGDGTLPK GLRGTKTTPE 601 MINRLKNNGI RFEPAPKREQ ARGGVPQYLA APSAQPTDKMLSPLFSTQTA 651 AYQAAIQQQT AAYQAALAQD TAAVTTGLAQ VQSAMASASQ TINTNVSLNI701 DGRVIANEVS RYQVAMFGRG AGQ*

a719.seq not found yet

a719.pep not found yet

g720.seq not found yet

g720.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2429>:

m720.seq 1 ATGAGCGGAT GGCATACCTT ATTGCAGGAC GCATCTTACA AGGGCGTCGG 51CTTTGATATT GAGGTGGTGG ACGAGAGCAA CGGCAAGGCA TTGGCCGAGC 101 ATGCGCGGCCGTTTGTGCAG GGTATCGACC TTGAAGACAT GGGCATGACC 151 GGGCGGCAGG TGCAGATTAATGCGGTGTTT TGGGGCAAGG GCTATGCAGG 201 CCGTCTGAAA AAGCTGCTGG ATGCGCTGGAGCAGCCGGGC GGCGGCGTGC 251 TGGTGCACCC TGTTTGGGGG CGGATGCACA ACATGATTGCGGCATCATGG 301 AGTTACCGAC ATGAGGCCGA TTATGTGGAT TATGCGGGCA TCGATATTAC351 TTTCCGCGAG GCGGCCGAAG CGCAGGAAAT CTTTGTTTTT GAAAACGCCT 401TTTTGGTCGA GCTTGAGGCG TTGATTGCTA ATATCGACAC CTACCGCGAG 451 GCGGCTATCGGCTTTGTTGA TGCGGTGTTG GCGGTGGATG CGGGCGTATC 501 AGCTTTATGG GGCAGCGCGCTGGGCATTTG GAGTGCGGCA TCGGGTACGT 551 TTGGCGCGGT GCGCCGTTTG TTTGATTTGGACAAAATTGC CTTTCCCGAT 601 CGGGGCGGAT ACAGTGCAGC GGCGTTTAAA AACGGCTCGGCCAAGCTGTT 651 TGCGGATATA TCGGTCATGG TAGATACTGG CATACGCCGT GAGGCGGGTT701 TGGCCGATAA TGCCATGCAC CATGCCGGTT GGTCGCCGCG ACAGCGGTTT 751GACGGGGCTG CGGCTGTTGC CGACCGCGCC GCCGCTATCC CTGATAATTT 801 GCTGACCGGCCGCTTTTCAG ACGGCCTGCA AAACCGCCTG AACCGGTTAA 851 CCGCCAAACA GGTGCAGCCGGTAGCGCAGG CGGTGCGCCT GTTATCCACG 901 TCATCGCTGT TGTCGGTGGC AACGGCATTAATCGAGGCGC ATGGCGAAGA 951 GATGACCGCG CCCGATTTGA TTGAGGTTAA CCGCGCCATGCGCCGCCGTA 1001 TGCAGGCCGA GATTGCCGCC TTGCGGGCGG TGCAGACGGC TGCTGCCGAG1051 TCTGGTGGGC TGACGGCCAA CGCCGTGTAT ACCGAGGCTT ACCAAACGGC 1101AGAATCCCTG CGCGCGGCGG CAGGCCGTCT GAATGCGTTG GTTGCGGCGG 1151 TCATCAACCAAAAGCCGCCG CTGATTGTGC GCCAAGCCCC AATCGACGGT 1201 ACGATACACC AAATCGCCCACGAGTTTTAC GGCGATATAG CCCGCGCAGC 1251 AGAGCTGGTG CGGCTCAATC CCCATATCCACCACCCCGCG TTTATCAAGC 1301 GCGGCACTTT GGTCAACAGC TATGCAAAAT AAThis corresponds to the amino acid sequence <SEQ ID 2430; ORF 720>:

m720.pep 1 MSGWHTLLQD ASYKGVGFDI EVVDESNGKA LAEHARPFVQ GIDLEDMGMT 51GRQVQINAVF WGKGYAGRLK KLLDALEQPG GGVLVHPVWG RMHNMIAASW 101 SYRHEADYVDYAGIDITFRE AAEAQEIFVF ENAFLVELEA LIANIDTYRE 151 AAIGFVDAVL AVDAGVSALWGSALGIWSAA SGTFGAVRRL FDLDKIAFPD 201 RGGYSAAAFK NGSAKLFADI SVMVDTGIRREAGLADNAMH HAGWSPRQRF 251 DGAAAVADRA AAIPDNLLTG RFSDGLQNRL NRLTAKQVQPVAQAVRLLST 301 SSLLSVATAL IEAHGEEMTA PDLIEVNRAM RRRMQAEIAA LRAVQTAAAE351 SGGLTANAVY TEAYQTAESL RAAAGRLNAL VAAVINQKPP LIVRQAPIDG 401TIHQIAHEFY GDIARAAELV RLNPHIHHPA FIKRGTLVNS YAK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2431>:

a720.seq (partial) 1 GGCCTGCAAA ACCGCCTGAA CCGGTTAACC GCCAAACAGGTGCAGCCGGT 51 AGCGCAGGCG GTGCGCCTGT TATCCACGTC ATCGCTGTTG TCGGTGGCAA 101CGGCATTAAT CGAGGCGCAT GGCGAAGAGA TGACCGCGCC CGATTTGATT 151 GAGGTTAACCGCGCCATGCG CCGCCGTATG CAGGCCGAGA TTGCCGCCTT 201 ACGGGCGGTG CAGACGGCTGCTGCCGAGTC TGGTGGGCTG ACGGCCAACG 251 CCGTGTATAC CGAGGCTTAC CAAACGGCAGAATCCCTGCG CGCGGCGGCA 301 GGCCGTCTGA ATGCGTTGGT TGCGGCGGTC ATCAACCAAAAGCCGCCGCT 351 GATTGTGCGC CAAGCCCCAA TCGACGGTAC GATACACCAA ATCGCCCACG401 AGTTTTACGG CGATATAGCC CGCGCAGCAG AGCTGGTGCG GCTCAATCCC 451CATATCCACC ACCCCGCGTT TATCAAGCGC GGCACTTTGG TCAACAGCTA 501 TGCAAAATAAThis corresponds to the amino acid sequence <SEQ ID 2432; ORF 720.a>:

a720.pep (partial) 1 GLQNRLNRLT AKQVQPVAQA VRLLSTSSLL SVATALIEAHGEEMTAPDLI 51 EVNRAMRRRM QAEIAALRAV QTAAAESGGL TANAVYTEAY QTAESLRAAA 101GRLNALVAAV INQKPPLIVR QAPIDGTIHQ IAHEFYGDIA RAAELVRLNP 151 HIHHPAFIKRGTLVNSYAK* m720/a720 100.0% identity in 169 aa overlap   250       260       270       280       290       300 m720.pepSPRQRFDGAAAVADRAAAIPDNLLTGRFSDGLQNRLNRLTAKQVQPVAQAVRLLSTSSLL                              |||||||||||||||||||||||||||||| a720                              GLQNRLNRLTAKQVQPVAQAVRLLSTSSLL                                      10        20        30   310       320       330       340       350       360 m720.pepSVATALIEAHGEEMTAPDLIEVNRAMRRRMQAEIAALRAVQTAAAESGGLTANAVYTEAY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a720SVATALIEAHGEEMTAPDLIEVNRAMRRRMQAEIAALRAVQTAAAESGGLTANAVYTEAY        40        50        60        70        80        90   370       380       390       400       410       420 m720.pepQTAESLRAAAGRLNALVAAVINQKPPLIVRQAPIDGTIHQIAHEFYGDIARAAELVRLNP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a720QTAESLRAAAGRLNALVAAVINQKPPLIVRQAPIDGTIHQIAHEFYGDIARAAELVRLNP       100       110       120       130       140       150   430       440 m720.pep HIHHPAFIKRGTLVNSYAKX |||||||||||||||||||| a720HIHHPAFIKRGTLVNSYAKX        160       170

g721.seq not found

g721.pep not found

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2433>:

m721.seq 1 ATGTCCAAAA ATGCACAAAA AACCCTACTT GCCGTGTGCA GTTTCGAGGT 51GCAGCCAAAA GACGGGCGAA TCCAACTGCT GCCATATGGC GAATTTCGCG 101 CAGTAGACGGTCGTCCGACT GATGTCCCTG CGTGGTATCT GACCGAAGAA 151 AACGGTCATG ATGTCGCGTTGTTGGCCAAC AGCTCGCGCA ATCAGTTGGT 201 TGTCGATTAT GAACACCAGA CGCTCTACAAAGAGAAAAAC GGACAACCTG 251 CACCTGCCGC CGGTTGGATG CGTTGGCTGG AGTTCACGCCTAAAGGCATG 301 TTTGCCGAAG TGGAGTGGAC GGACAAGGCG GCTGCGGCAA TTGCCGCAAA351 AGAGTATCGC TACATCTCTG CTGTGTTTTC CTATGACACA AAGGGATATG 401TAAGCAAAAT TTTTCACGCC GCGCTGACAA ATTTCCCCGC GTTGGACGGT 451 ATGGACGAGGTGCTGGCGGC AGCGTCGGCG CAAATTTTAA AACCGGAAAC 501 GGAGCAAAAC CCTATGAAAGAGTTGTTACA GCAACTGTTC GACCTGCCTG 551 ATGCGGGCGA AGAAGAACTG AAGGCGGCATTGTCCGCGCT CGTGGAAGCC 601 AAGCCGAAAG ACGTGGCATT GTCTGCCGAC GTGTTCGCGCAGCTGGCGGA 651 AAAAGACAGC CGCATCGCGG CATTGACGGC GCAAACCGCC AAGCCTGATT701 TGACTAAATA CGCGCCTATC TCAGTGGTTC AAGAGCTGCA AAGCAAAGTC 751GCCGCGCTGA CTGCCAAGCA GGAAGCAGAC AAAGGCAACG AATTGATTAC 801 CGCCGCGCTGACTTCAGGCA AATTGCTGCC TGCTCAGAAG GAGTGGGCAA 851 AAGGCGTATT GAAACAGCCGGGCGGCTTGG CATTTTTGAC CGGCTTTATT 901 GAAAACGCCC AGCCGGTCGC TGCACTGGCAGGCTCGCAAA CGGGCGGCAA 951 AGCACCCGAC GAACGCGTCG CCGCACTGAC TGCGGAAGAGGCAGCCGCAG 1001 CAAAAATGCT GGGCATGTCC GGCGAAGAAT TTGTAAAAAT CAAAGAAAGC1051 GAAGGTAAGT AAThis corresponds to the amino acid sequence <SEQ ID 2434; ORF 721>:

m721.pep 1 MSKNAQKTLL AVCSFEVQPK DGRIQLLPYG EFRAVDGRPT DVPAWYLTEE 51NGHDVALLAN SSRNQLVVDY EHQTLYKEKN GQPAPAAGWM RWLEFTPKGM 101 FAEVEWTDKAAAAIAAKEYR YISAVFSYDT KGYVSKIFHA ALTNFPALDG 151 MDEVLAAASA QILKPETEQNPMKELLQQLF DLPDAGEEEL KAALSALVEA 201 KPKDVALSAD VFAQLAEKDS RIAALTAQTAKPDLTKYAPI SVVQELQSKV 251 AALTAKQEAD KGNELITAAL TSGKLLPAQK EWAKGVLKQPGGLAFLTGFI 301 ENAQPVAALA GSQTGGKAPD ERVAALTAEE AAAAKMLGMS GEEFVKIKES351 EGK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2435>:

a721.seq 1 ATGTCCAAAA ATGCACAAAA AACCCTACTT GCCGTGTGCA GTTTCGAGGT 51GCAGCCAAAA GACGGGCGAA TCCAACTGCT GCCATATGGC GAATTTCGCG 101 CAGTAGACGGTCGTCCGACT GATGTCCCTG CGTGGTATCT GACCGAAGAA 151 AACGGTCATG ATGTCGCGTTGTTGGCCAAC AGCTCGCGCA ATCAGTTGGT 201 TGTCGATTAT GAACACTAGA CGCTCTACAAAGAGAAAAAC GGACAACCTG 251 CACCTGCCGC CGGTTGGATG CGTTGGCTGG AGTTCACGCCTAAAGGCATG 301 TTTGCCGAAG TGGAGTGGAC GGACAAGGCG GCTGCGGCAA TTGCCGCAAA351 AGAGTATCGC TACATCTCTG CTGTGTTTTC CTATGACACA AAGGGATATG 401TAAGCAAAAT TTTTCACGCC GCGCTGACAA ATTTCCCCGC GTTGGACGGT 451 ATGGACGAGGTGCTGGCGGC AGCGTCGGCG CAAATTTTAA AACCGGAAAC 501 GGAGCAAAAC CCTATGAAAGAGTTGTTACA GCAACTGTTC GGTCTGCCTG 551 ATGCGGGCGA AGAAGAACTG AAGGCGGCATTGTCCGCGCT CGTGGAAGCC 601 AAGCCGAAAG ACGTGGCATT GTCTGCCGAC GTGTTCGCGCAGCTGGCGGA 651 AAAAGACAGC CGCATCGCGG CATTGACGGC GCAAACCGCC AAGCCTGATT701 TGACTAAATA CGCGCCTATC TCAGTGGTTC AAGAGCTGCA AAGCAAAGTC 751GCCGCGCTGA CTGCCAAGCA GGAAGCAGAC AAAGGCAACG AATTGATTAC 801 CGCCGCGCTGACTTCAGGCA AATTGCTGCC TGCTCAGAAG GAGTGGGCAG 851 AAGGCGTATT GAAACAGCCGGGCGGCTTGG CATTTTTGAC CGGCTTTATT 901 GAAAACGCCC AGCCGGTCGC TGCACTGGCAGGCTCGCAAA CGGGCGGTAA 951 AGCACCCGAC GAACGCGTCG CCGCACTGAC TGCGGAAGAGGCAGCCGCAG 1001 CAAAAATGCT GGGCATGTCC GGCGAAGAAT TTGTAAAAAT CAAAGAAAGC1051 GAAGGTAAGT AAThis corresponds to the amino acid sequence <SEQ ID 2436; ORF 721.a>:

a721.pep 1 MSKNAQKTLL AVCSFEVQPK DGRIQLLPYG EFRAVDGRPT DVPAWYLTEE 51NGHDVALLAN SSRNQLVVDY EH*TLYKEKN GQPAPAAGWM RWLEFTPKGM 101 FAEVEWTDKAAAAIAAKEYR YISAVFSYDT KGYVSKIFHA ALTNFPALDG 151 MDEVLAAASA QILKPETEQNPMKELLQQLF GLPDAGEEEL KAALSALVEA 201 KPKDVALSAD VFAQLAEKDS RIAALTAQTAKPDLTKYAPI SVVQELQSKV 251 AALTAKQEAD KGNELITAAL TSGKLLPAQK EWAEGVLKQPGGLAFLTGFI 301 ENAQPVAALA GSQTGGKAPD ERVAALTAEE AAAAKMLGMS GEEFVKIKES351 EGK* a721/m721 99.2% identity in 353 aa overlap        10        20        30        40        50        60 a721.pepMSKNAQKTLLAVCSFEVQPKDGRIQLLPYGEFRAVDGRPTDVPAWYLTEENGHDVALLAN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m721MSKNAQKTLLAVCSFEVQPKDGRIQLLPYGEFRAVDGRPTDVPAWYLTEENGHDVALLAN        10        20        30        40        50        60        70        80        90       100       110       120 a721.pepSSRNQLVVDYEHXTLYKEKNGQPAPAAGWMRWLEFTPKGMFAEVEWTDKAAAAIAAKEYR|||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||| m721SSRNQLVVDYEHQTLYKEKNGQPAPAAGWMRWLEFTPKGMFAEVEWTDKAAAAIAAKEYR        70        80        90       100       110       120       130       140       150       160       170       180 a721.pepYISAVFSYDTKGYVSKIFHAALTNFPALDGMDEVLAAASAQILKPETEQNPMKELLQQLF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m721YISAVFSYDTKGYVSKIFHAALTNFPALDGMDEVLAAASAQILKPETEQNPMKELLQQLF       130       140       150       160       170       180       190       200       210       220       230       240 a721.pepGLPDAGEEELKAALSALVEAKPKDVALSADVFAQLAEKDSRIAALTAQTAKPDLTKYAPI||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m721DLPDAGEEELKAALSALVEAKPKDVALSADVFAQLAEKDSRIAALTAQTAKPDLTKYAPI       190       200       210       220       230       240       250       260       270       280       290       300 a721.pepSVVQELQSKVAALTAKQEADKGNELITAALTSGKLLPAQKEWAEGVLKQPGGLAFLTGFI|||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||| m721SVVQELQSKVAALTAKQEADKGNELITAALTSGKLLPAQKEWAKGVLKQPGGLAFLTGFI       250       260       270       280       290       300       310       320       330       340       350 a721.pepENAQPVAALAGSQTGGKAPDERVAALTAEEAAAAKMLGMSGEEFVKIKESEGKX|||||||||||||||||||||||||||||||||||||||||||||||||||||| m721ENAQPVAALAGSQTGGKAPDERVAALTAEEAAAAKMLGMSGEEFVKIKESEGKX       310       320       330       340       350

g722.seq not found yet

g722.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2437>:

m722.seq 1 GTGTTTGAAA CGCCGACATT TGAGCAAATC CGCGAGCGTA TCCTGCGCGA 51TACCAAAAGC CTGTGGCCGG ATGCCGATAT CAGCCCCGAC AGCGACCATT 101 ATGTGCACGCCAGCCGTTTG GCCAGCTGCG CCGAAGGGCA ATATGCGCAT 151 CAAAGCTGGA TTGTGCGGCAGATTTTCCCT GATACCGCCG ACCGCGAGTA 201 TTTGGAGCGG CATGCCTCCA TGCGCGGCTTGAGCCGCCGC AATCCTACCA 251 CGGCCAGCGG CACGCTGACC GTAAGCGGTA TTGCGCAATCCATGCTTTCA 301 GACGACCTGC AAGTGCGTAT CGGCCAGCGT TTTTACCGCA CTACCGCCCG351 CGCCGTTATC GGCAGCGGCG GCACGGCGGA AATACCGGCA ATCGCCGACG 401AGCCGGGCGC GGCCGCCAAT GTGGGCGACG GCGAGGCGCA ACTGATGGCC 451 GCCCCCGCCGGTGTGGCCAC CGAATGCCGC CTTACCGTAC AAGGCGGCAC 501 CGACCGAGAA AGCGATGCCTCACTGCTGGC GCGTCTGTTG GAAATCATCC 551 GCCGACCGCC CGCAGGCGGC AACCGTTACGACTATAAAAA CTGGGCGTTG 601 AGTGTTGACG GCGTAACCAG CGCATATGTT TATCCGCTGCGCCGCGGCTT 651 GGGTACGGTG GATATTGCCA TTACCTCCGC CGACGGTGTG TCGTCGGAAG701 AAACTGTGCG CCGCGTACAG GCTTATATCG ACGAGATGCG CCCGGTAACG 751GCAAAAAATG CGCTGGTACT CAAGCCAACC GTAACGGCGG TGCCTGTTAC 801 CGTGCAAGTCAAGCTCGACG GTATCGACTT GGACGAGGCC AAGCGCCGCA 851 TACGGACGGC CCTAAAAGAATATTTCGACA CCCTGATCCC CGGCGACGGC 901 CTGACTGTGT CGCAAATCGA GGCTGCTATCAGCAATGTGG ATGGTGTGAT 951 CGACCGCCGT CTGACTGCGC CGACGGCCAA CCGTGCCGCCGATACGGTTA 1001 ACCGCATCGA GTGGTTTAAA GCGGGCGCGA TTAATGTAAC GGAGATGCCG1051 TCATGAThis corresponds to the amino acid sequence <SEQ ID 2438; ORF 722>:

m722.pep 1 VFETPTFEQI RERILRDTKS LWPDADISPD SDHYVHASRL ASCAEGQYAH 51QSWIVRQIFP DTADREYLER HASMRGLSRR NPTTASGTLT VSGIAQSMLS 101 DDLQVRIGQRFYRTTARAVI GSGGTAEIPA IADEPGAAAN VGDGEAQLMA 151 APAGVATECR LTVQGGTDRESDASLLARLL EIIRRPPAGG NRYDYKNWAL 201 SVDGVTSAYV YPLRRGLGTV DIAITSADGVSSEETVRRVQ AYIDEMRPVT 251 AKNALVLKPT VTAVPVTVQV KLDGIDLDEA KRRIRTALKEYFDTLIPGDG 301 LTVSQIEAAI SNVDGVIDRR LTAPTANRAA DTVNRIEWFK AGAINVTEMP351 S*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2439>:

a722.seq 1 GTGTTTGAAA CGCCGACATT TGAGCAAATC CGCGAGCGTA TCCTGCGCGA 51TACCAAAAGC CTGTGGCCGG ATGCCGATAT CAGCCCCGAC AGCGACCATT 101 ATGTGCACGCCAGCCGTTTG GCCAGCTGCG CCGAAGGGCA ATATGCGCAT 151 CAAAGCTGGA TTGTGCGGCAGATTTTCCCT GATACCGCCG ACCGCGAGTA 201 TTTGGAGCGG CATGCCTCCA TGCGCGGCTTGCGCCGCCGC AATCCTACCA 251 CGGCCAGCGG CACGCTGACC GTAAGCGGTA TTGCGCAATCCATGCTTTCA 301 GACGGCCTGC AAGTGCGTAT CGGCCAGCGT TTTTACCGCA CTACCGCCCG351 CGCCGTTATC GGCAGCGGCG GCACGGCGGA AATACCGGCA ATCGCCGACG 401AGCCGGGCGC GGCCGCCAAT GTGCGCGACG GCGAGGCGCA ACTGATGGCC 451 GCCCCCGCCGGTGTGTCCAC CGAATGCCGC CTTACCGTAC AAGGCGGCAC 501 CGACCGAGAA AGCGATGCCTCACTGCTGGC GCGTCTGTTG GAAATCATCC 551 GCCGACCGCC CGCAGGCGGC AACCGTTACGACTATAAAAA CTGGGCGTTG 601 AGTGTTGACG GCGTAACCAG CGCATATGTT TATCCGCTGCGCCGCGGCTT 651 GGGTACGGTG GATATTGCCA TTACCTCCGC CGACGGTGTG CCATCGGAAG701 AAACTGTGCG CCGCGTACAG GCTTATATCG ACGAGATGCG CCCGGTAACG 751GCAAAAAATG CGCTGGTACT CAAGCCAACC GTAACGGCGG TGCCTGTTAC 801 CGTGCAAGTCAAGCTCGACG GCATCGACTT GGACGAGGCC AAGCGCCGCA 851 TACGGACGGC CCTAAAAGAATATTTCGACA CCCTGATCCC CGGCGACGGC 901 CTGACTGTGT CGCAAATCGA GGCGGCTATCAGCAATGTGG ATGGTGTGAT 951 CGACCTCCGT CTGACTGCGC CGACGGCCAA CCGTGCCGCCGATACGGTTA 1001 ACCGCATCGA GTGGTTTAAA GCGGGCGCGA TTAATGTAAC GGAGATGCCG1051 TCATGAThis corresponds to the amino acid sequence <SEQ ID 2440; ORF 722.a>:

a722.pep 1 VFETPTFEQI RERILRDTKS LWPDADISPD SDHYVHASRL ASCAEGQYAH 51QSWIVRQIFP DTADREYLER HASMRGLRRR NPTTASGTLT VSGIAQSMLS 101 DGLQVRIGQRFYRTTARAVI GSGGTAEIPA IADEPGAAAN VRDGEAQLMA 151 APAGVSTECR LTVQGGTDRESDASLLARLL EIIRRPPAGG NRYDYKNWAL 201 SVDGVTSAYV YPLRRGLGTV DIAITSADGVPSEETVRRVQ AYIDEMRPVT 251 AKNALVLKPT VTAVPVTVQV KLDGIDLDEA KRRIRTALKEYFDTLIPGDG 301 LTVSQIEAAI SNVDGVIDLR LTAPTANRAA DTVNRIEWFK AGAINVTEMP351 S*

g723.seq not found yet

g723.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2441>:

m723.seq 1 ATGCGACCCA AGCCCCGTTT CAGACGGTCT GTTATCGCTT GCTCAATATC 51AGTGATCACG CCCGAACACC TTATTTTTAC CGTTTACAAA CACAATACCG 101 TCTTCGCCCGCGGCCACTTC TTCGCCGCTA TCATCCACGC CCAGCTGCAC 151 TTCGCCTTTG GCCATAGCACGCAGCAGGTC GAGCACGTCG ATTTTGTAGC 201 GGTTGCGGAT TTCGTCGGTA ATCAACACGCCCTGAGCCGC CGTCAGACGG 251 TAGCGGGCAA TGTCGCAGCA AAGGCGCACC AAGATGGGCGGCAGATCCTC 301 AAAAGGTCGT CTGAACCGCC CCAGATACGC GTCGATTTCG GCAGTGGCGT351 CCACCAGCGC GGTTTGTGCG ACCTCGCGGT CAATCAGCCC CTCGTTGTTG 401CGGTCGGTGA GCTGCAAGAC TTCCAGCTCA CCGAAACGCG CAACCATATC 451 CTCAACCGTCGCGTATGCCA TTACTCGACC GCCTTGCGTT GCAGCATAGG 501 CTCGGCGCAG ATTGCCTTCCACACCGCTTC GCCGACTTCG GCGCGCTTCA 551 CTTCGCGCCA GCCGCCGTCA AACAGCAGGCCGCCGCGCCA AAATTCTTTG 601 CCGTCTGCGC CGGTACTGAC GAGCATCACA TCGCGGCTGTCCGCCAAAGC 651 GTCGGCGGCA CGTTGCGTAT GCTGCACTTT GAGTTCGGCA AGTTCGGCGG701 ACAGTGCCTT TTTGTCGTCT TCGGCTTTTT CCAAGGCTGT GGTCAGCATT 751TCGACATCGT TTCGGGCGGC GGCAAGCTCT GCCTGCACGG CGTCCAATTC 801 GGCTTTGATGTCTTCAAACG ACGGGGCGGC GGTTTCGGCG GTTTCTGGTT 851 TGTTGTTGGT TTTTGCCATGATGACTCCTT GTTTCAGACG GCGGCGGATT 901 CGCATTTGAThis corresponds to the amino acid sequence <SEQ ID 2442; ORF 723>:

m723.pep 1 MRPKPRFRRS VIACSISVIT PEHLIFTVYK HNTVFARGHF FAAIIHAQLH 51FAFGHSTQQV EHVDFVAVAD FVGNQHALSR RQTVAGNVAA KAHQDGRQIL 101 KRSSEPPQIRVDFGSGVHQR GLCDLAVNQP LVVAVGELQD FQLTETRNHI 151 LNRRVCHYST ALRCSIGSAQIAFHTASPTS ARFTSRQPPS NSRPPRQNSL 201 PSAPVLTSIT SRLSAKASAA RCVCCTLSSASSADSAFLSS SAFSKAVVSI 251 STSFRAAASS ACTASNSALMSSNDGAAVSA VSGLLLVFAM MTPCFRRRRI 301 RI*

a723.seq not found yet

a723.pep not found yet

g724.seq not found yet

g724.pep not found yet

The following partial DNA sequence, shown with its encoded amino acidsequence, was identified in N. meningitidis <SEQ ID 2443>:

m724.map ATGAGTTTGAGTAAATTGGCGAAAAAAACGGCACAAACTGCTAAAAATATCGGCGAAACC 1---------+---------+---------+---------+---------+---------+  60TACTCAAACTCATTTAACCGCTTTTTTTGCCGTGTTTGACGATTTTTATAGCCGCTTTGG aM  S  L  S  K  L  A  K  K  T  A  Q  T  A  K  N  I  G  E  T -CTGCGCGCGGCCTTTCGGGGAAAAATCACGCTGGTGGTGTCGTCCGAGCCGATACAGCGC 61---------+---------+---------+---------+---------+---------+ 120GACGCGCGCCGGAAAGCCCCTTTTTAGTGCGACCACCACAGCAGGCTCGGCTATGTCGCG aL  R  A  A  F  R  G  K  I  T  L  V  V  S  S  E  P  I  Q  R -GTGCAGTTGAGCGGCTTGGCCGACGAAACCCTGCAAGACCTTGAACATTTGCAGGAATAC 121---------+---------+---------+---------+---------+---------+ 180CACGTCAACTCGCCGAACCGGCTGCTTTGGGACGTTCTGGAACTTGTAAACGTCCTTATG aV  Q  L  S  G  L  A  D  E  T  L  Q  D  L  E  H  L  Q  E  Y -GGCTTTGCCAGCCATCCGCCCGACGGCAGCGAAGCGGTAGTGATACCGCTGGGCGGCAAT 181---------+---------+---------+---------+---------+---------+ 240CCGAAACGGTCGGTAGGCGGGCTGCCGTCGCTTCGCCATCACTATGGCGACCCGCCGTTA aG  F  A  S  H  P  P  D  G  S  E  A  V  V  I  P  L  G  G  N -ACTTCGCACGGTGTGATTGTGTGCAGCCAGCACGGCAGCTACCGCATCAAAAACCTTAAG 241---------+---------+---------+---------+---------+---------+ 300TGAAGCGTGCCACACTAACACACGTCGGTCGTGCCGTCGATGGCGTAGTTTTTGGAATTC aT  S  H  G  V  I  V  C  S  Q  H  G  S  Y  R  I  K  N  L  K -CCCGGCGAGACGGCGATTTTTAATCATGAGGGTGCAAAAATCGTGATTAAGCAAGGCAAA 301---------+---------+---------+---------+---------+---------+ 360GGGCCGCTCTGCCGCTAAAAATTAGTACTCCCACGTTTTTAGCACTAATTCGTTCCGTTT aP  G  E  T  A  I  F  N  H  E  G  A  K  I  V  I  K  Q  G  K -ATCATTGAGGCCGATTGCGACGTGTACCGGGTTAACTGCAAACAATACGAGGTTAATGCG 361---------+---------+---------+---------+---------+---------+ 420TAGTAACTCCGGCTAACGCTGCACATGGCCCAATTGACGTTTGTTATGCTCCAATTACGC aI  I  E  A  D  C  D  V  Y  R  V  N  C  K  Q  Y  E  V  N  A -GCCACGGATGCCAAATTTAACGCTCCGTTGGTGGAGACCAGTGCAGTGTTGACGGCGCAA 421---------+---------+---------+---------+---------+---------+ 480CGGTGCCTACGGTTTAAATTGCGAGGCAACCACCTCTGGTCACGTCACAACTGCCGCGTT aA  T  D  A  K  F  N  A  P  L  V  E  T  S  A  V  L  T  A  Q -GGCCAAATCAACGGCAACGGCGGCATGGCCGTCGAGGGCGGCGACGGAGCCACCTTTAGC 481---------+---------+---------+---------+---------+---------+ 540CCGGTTTAGTTGCCGTTGCCGCCGTACCGGCAGCTCCCGCCGCTGCCTCGGTGGAAATCG aG  Q  I  N  G  N  G  G  M  A  V  E  G  G  D  G  A  T  F  S -GGCGATGTTAACCAAACGGGCGGCAGCTTTAACACCGACGGCGACGTGGTGGCCGGCAAT 541---------+---------+---------+---------+---------+---------+ 600CCGCTACAATTGGTTTGCCCGCCGTCGAAATTGTGGCTGCCGCTGCACCACCGGCCGTTA aG  D  V  N  Q  T  G  G  S  F  N  T  D  G  D  V  V  A  G  N -ATATCGTTGCGCCAGCACCCGCATACCGACAGCATCGGCGGCAAAACCTTACCGGCGGAA 601---------+---------+---------+---------+---------+---------+ 660TATAGCAACGCGGTCGTGGGCGTATGGCTGTCGTAGCCGCCGTTTTGGAATGGCCGCCTT aI  S  L  R  Q  H  P  H  T  D  S  I  G  G  K  T  L  P  A  E - CCGGCATAG661 --------- 669 GGCCGTATC a P  A  * - Enzymes that do cut: NONEEnzymes that do not cut: BamHI BglII EcoRI HindIII KpnI NdeI NheI PstISacI SalI SmaI SphI XbaI XhoIThis corresponds to the amino acid sequence <SEQ ID 2444; ORF 724>:

m724.pep 1 MSLSKLAKKT AQTAKNIGET LRAAFRGKIT LVVSSEPIQR VQLSGLADET 51LQDLEHLQEY GFASHPPDGS EAVVIPLGGN TSHGVIVCSQ HGSYRIKNLK 101 PGETAIFNHEGAKIVIKQGK IIEADCDVYR VNCKQYEVNA ATDAKFNAPL 151 VETSAVLTAQ GQINGNGGMAVEGGDGATFS GDVNQTGGSF NTDGDVVAGN 201 ISLRQHPHTD SIGGKTLPAE PA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2445>:

a724.seq 1 ATGAGTTTGA GTAAATTGGC GAAAAAAACG GCACAAACTG CTAAAAATAT 51CGGCGAAACC CTGCGCGCGG CCTTTCGGGG AAAAATCACG CTGGTGGTGT 101 CGTCCGAGCCGATACAGCGC GTGCAGTTGA GCGGCTTGGC CGACGAAACC 151 CTGCAAGACC TTGAACATTTGCAGGAATAC GGCTTTGCCA GCCATCCGCC 201 CGACGGCAGC GAAGCGGTAG TGATACCGCTGGGCGGCAAT ACTTCGCACG 251 GTGTGATTGT GTGCAGCCAG CACGGCAGCT ACCGCATCAAAAACCTTAAG 301 CCCGGCGAGA CGGCGATTTT TAATCATGAG GGTGCAAAAA TCGTGATTAA351 GCAAGGCAAA ATCATTGAGG CCGATTGCGA CGTGTACCGG GTTAACTGCA 401AACAATACGA GGTTAATGCG GCCACGGATG CCAAATTTAA CGCTCCGTTG 451 GTGGAGACCAGTGCAGTGTT GACGGCGCAA GGCCAAATCA ACGGCAACGG 501 CGGCATGGCC GTCGAGGGCGGCGACGGAGC CACCTTTAGC GGCGATGTTA 551 ACCAAACGGG CGGCAGCTTT AACACCGACGGCGACGTGGT GGCCGGCAAT 601 ATATCGTTGC GCCAGCACCC GCATACCGAC AGCATCGGCGGCAAAACCTT 651 ACCGGCGGAA CCGGCATAGThis corresponds to the amino acid sequence <SEQ ID 2446; ORF 724.a>:

a724.pep 1 MSLSKLAKKT AQTAKNIGET LRAAFRGKIT LVVSSEPIQR VQLSGLADET 51LQDLEHLQEY GFASHPPDGS EAVVIPLGGN TSHGVIVCSQ HGSYRIKNLK 101 PGETAIFNHEGAKIVIKQGK IIEADCDVYR VNCKQYEVNA ATDAKFNAPL 151 VETSAVLTAQ GQINGNGGMAVEGGDGATFS GDVNQTGGSF NTDGDVVAGN 201 ISLRQHPHTD SIGGKTLPAE PA* a724/m724100.0% identity in 222 aa overlap        10        20        30        40        50        60 a724.pepMSLSKLAKKTAQTAKNIGETLRAAFRGKITLVVSSEPIQRVQLSGLADETLQDLEHLQEY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m724MSLSKLAKKTAQTAKNIGETLRAAFRGKITLVVSSEPIQRVQLSGLADETLQDLEHLQEY        10        20        30        40        50        60        70        80        90       100       110       120 a724.pepGFASHPPDGSEAVVIPLGGNTSHGVIVCSQHGSYRIKNLKPGETAIFNHEGAKIVIKQGK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m724GFASHPPDGSEAVVIPLGGNTSHGVIVCSQHGSYRIKNLKPGETAIFNHEGAKIVIKQGK        70        80        90       100       110       120       130       140       150       160       170       180 a724.pepIIEADCDVYRVNCKQYEVNAATDAKFNAPLVETSAVLTAQGQINGNGGMAVEGGDGATFS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m724IIEADCDVYRVNCKQYEVNAATDAKFNAPLVETSAVLTAQGQINGNGGMAVEGGDGATFS       130       140       150       160       170       180       190       200       210       220 a724.pepGDVNQTGGSFNTDGDVVAGNISLRQHPHTDSIGGKTLPAEPAX||||||||||||||||||||||||||||||||||||||||||| m724GDVNQTGGSFNTDGDVVAGNISLRQHPHTDSIGGKTLPAEPAX       190       200       210       220

g725.seq not found yet

g725.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2447>:

m725.seq 1 ATGGTGCGCA CGGTTAAAAG CTACAACGGC GAGGCCGACG ATTTGGCGGG 51GCAAATCCAT ACGCTGCCTG CGGTTTGGGT AACGTATGGC GGCAGCAAAG 101 TTGAGCCTGCCAGCACCGGC GGCGTATGCG GACGTTATCA GGATACCGCC 151 GAATTTGTGG TGATGGTGGCGGCCCGCAAT CTGCGCAACG AGCAGGCGCA 201 GCGGCAAGGC GGCATCGACA GCCGCGAAATCGGCAGCAAC GATTTAATCC 251 GCGCTGTTCG CCGCCTGCTT GACGGCCAGC GGCTCGGTTTTGCCGATAGC 301 CGCGGCTTGG TGCCCAAAGC GGTGCGCGCG ATTGCCAATC ATGTGCTGGT351 GCAAAACGCC GCAGTAAGCA TATATGCGGT TGAGTATGCC ATCCGCTTTA 401ACACCTGCGG GTTGGAAAAT GACCGCTACC CCGAACGCAC CGACAATCCC 451 GACGACCCCAACCATATCTT TACCAAGTAT CAGGGTACAT TGAGCGAGCC 501 GTGGCCTGAT TTCGAGGGGTTGGACGGCAA AATTTACGAC CCGCAATCCG 551 CCGATGAAAT ACCTGTAAAC CTAACCCTTAAGGATAAGCA ATGAThis corresponds to the amino acid sequence <SEQ ID 2448; ORF 725>:

m725.pep 1 MVRTVKSYNG EADDLAGQIH TLPAVWVTYG GSKVEPASTG GVCGRYQDTA 51EFVVMVAARN LRNEQAQRQG GIDSREIGSN DLIRAVRRLL DGQRLGFADS 101 RGLVPKAVRAIANHVLVQNA AVSIYAVEYA IRFNTCGLEN DRYPERTDNP 151 DDPNHIFTKY QGTLSEPWPDFEGLDGKIYD PQSADEIPVN LTLKDKQ*

a725.seq not found yet

a725.pep not found yet

g726.seq not found yet

g726.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2449>:

m726.seq 1 ATGACCATCT ATTTCAAAAA CGGCTTTTAC GACGACACAT TGGGCGGCAT 51CCCCGAAGGC GCGGTTGCCG TCCGCGCCGA AGAATACGCC GCCCTTTTGG 101 CAGGACAGGCGCAGGGCGGG CAGATTGCCG CAGATTCCGA CGGCCGCCCC 151 GTTTTAACCC CGCCGCGCCCGTCCGATTAC CACGAATGGG ACGGCAAAAA 201 ATGGAAAATC AGCAAAGCCG CCGCCGCCGCCCGTTTCGCC AAACAAAAAA 251 CCGCCTTGGC ATTCCGCCTC GCGGAAAAGG CGGACGAACTCAAAAACAGC 301 CTCTTGGCGG GCTATCCCCA AGTGGAAATC GACAGCTTTT ACAGGCAGGA351 AAAAGAAGCC CTCGCGCGGC AGGCGGACAA CAACGCCCCG ACCCCGATGC 401TGGCGCAAAT CGCCGCCGCA AGGGGCGTGG AATTGGACGT TTTGATTGAA 451 AAAGTTATCGAAAAATCCGC CCGCCTGGCT GTTGCCGCCG GCGCGATTAT 501 CGGAAAGCGT CAGCAGCTCGAAGACAAATT GAACACCATC GAAACCGCGC 551 CCGGATTGGA CGCGCTGGAA AAGGAAATCGAAGAATGGAC GCTAAACATC 601 GGCTGAThis corresponds to the amino acid sequence <SEQ ID 2450; ORF 726>:

m726.pep 1 MTIYFKNGFY DDTLGGIPEG AVAVRAEEYA ALLAGQAQGG QIAADSDGRP 51VLTPPRPSDY HEWDGKKWKI SKAAAAARFA KQKTALAFRL AEKADELKNS 101 LLAGYPQVEIDSFYRQEKEA LARQADNNAP TPMLAQIAAA RGVELDVLIE 151 KVIEKSARLA VAAGAIIGKRQQLEDKLNTI ETAPGLDALE KEIEEWTLNI 201 G*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2451>:

a726.seq 1 ATGACCATCT ATTTCAAAAA CGGCTTTTAC GACGACACCT TGGGCAGCAT 51CCCCGAAGGC GCGGTTGCCG TCCGCGCCGA AGAATACGCC GCCCTTTTGG 101 CAGGACAGGCGCAGGGCGGG CAGATTGCCG CAGATTCCGA CGGCCGCCCC 151 GTTTTAACCC CGCCGCGCCCGTCCGAATAC CACGAATGGG ACGGCAAGAA 201 ATGGGAAATC GGCGAAGCCG CTGCCGCCGCCCGTTTCGCC GAACAAAAAA 251 CCGCCACGGC ATTCCGCCTC GCGGCAAAGG CGGACGAACTCAAAAACAGC 301 CTCTTGGCGG GCTATCCCCA AGTGGAAATC GACAGCTTTT ACAGGCAGGA351 AAAAGAAGCC CTCGCGCGGC AGGCGGACAA CAACGCCCCG ACCCCGATGC 401TGGCGCAAAT CGCCGCCGCA AGGGGCGTGG AATTGGACGT TTTGATTGAA 451 AAAGTTGTCGAAAAATCCGC CCGCCTGGCC GTTGCCGCCG GCGCGATTAT 501 CGGAAAGCGG CAGCAGCTCGAAGACAAATT GAACACCATC GAAACCGCGC 551 CAGGATTGGA CGCGCTGGAA AAGGAAATCGAAGAATGGAC GCTAAACATC 601 GGCTGAThis corresponds to the amino acid sequence <SEQ ID 2452; ORF 726.a>:

a726.pep 1 MTIYFKNGFY DDTLGSIPEG AVAVRAEEYA ALLAGQAQGG QIAADSDGRP 51VLTPPRPSEY HEWDGKKWEI GEAAAAARFA EQKTATAFRL AAKADELKNS 101 LLAGYPQVEIDSFYRQEKEA LARQADNNAP TPMLAQIAAA RGVELDVLIE 151 KVVEKSARLA VAAGAIIGKRQQLEDKLNTI ETAPGLDALE KEIEEWTLNI 201 G* a726/m726 95.5% identity in 201aa overlap         10        20        30        40        50        60a726.pep MTIYFKNGFYDDTLGSIPEGAVAVRAEEYAALLAGQAQGGQIAADSDGRPVLTPPRPSEY|||||||||||||||:||||||||||||||||||||||||||||||||||||||||||:| m726MTIYFKNGFYDDTLGGIPEGAVAVRAEEYAALLAGQAQGGQIAADSDGRPVLTPPRPSDY        10        20        30        40        50        60        70        80        90       100       110       120 a726.pepHEWDGKKWEIGEAAAAARFAEQKTATAFRLAAKADELKNSLLAGYPQVEIDSFYRQEKEA||||||||:|::||||||||:|||| ||||| |||||||||||||||||||||||||||| m726HEWDGKKWKISKAAAAARFAKQKTALAFRLAEKADELKNSLLAGYPQVEIDSFYRQEKEA        70        80        90       100       110       120       130       140       150       160       170       180 a726.pepLARQADNNAPTPMLAQIAAARGVELDVLIEKVVEKSARLAVAAGAIIGKRQQLEDKLNTI||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||| m726LARQADNNAPTPMLAQIAAARGVELDVLIEKVIEKSARLAVAAGAIIGKRQQLEDKLNTI       130       140       150       160       170       180       190       200 a726.pep ETAPGLDALEKEIEEWTLNIGX|||||||||||||||||||||| m726 ETAPGLDALEKEIEEWTLNIGX        190       200

g727.seq not found yet

g727.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2453>:

m727.seq 1 ATGAATCTCG TGAAACTGCT GGCGAATAAC TGGCAACCGA TTGCCATTAT 51CGCGCTTGTC GGCACGGGCT TGGCTGTGTC GCACCATCAA GGCTACAAGT 101 CGGCATTTGCGAAGCAGCAG GCGGTCATCG ACAAGATGGA GCGCGACAAG 151 GCGCAAGCCC TGCTGTTGTCGGCTCAAAAC TATGCGCGCG AACTGGAACT 201 GGCACGCGCG GAAGCTAAAA AATATGAAGTCAAGGCGCAC GCTGTCGGCA 251 TGGCTTTGGC GAAAAAACAG GCGGAAGTCA GCCGTCTGAAAACGGAAAGA 301 GACCTTTGCA AAATTCCTTT CCCTCCCGAC AGCCGAAACC CAAACACAGG351 TTTTCGGCTG TTTTCGCCCC AAATACCGCC TAATTTTACC CAAATACCCC 401 CTTAAThis corresponds to the amino acid sequence <SEQ ID 2454; ORF 727>:

m727.pep 1 MNLVKLLANN WQPIAIIALV GTGLAVSHHQ GYKSAFAKQQ AVIDKMERDK 51AQALLLSAQN YARELELARA EAKKYEVKAH AVGMALAKKQ AEVSRLKTER 101 DLCKIPFPPDSRNPNTGFRL FSPQIPPNFT QIPP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2455>:

a727.seq 1 ATGAATCTCG TGAAACTGCT GGCGAATAAC TGGCAACCGA TTGCCATCAT 51CGCGCTTGTC GGCACGGGTT TGGCGGTGTC GCACCATCAA GGCTACAAGT 101 CGGCTTTTGCGAAGCAGCAG GCGGTCATTG AGAAAATGAA GCGCGACAAG 151 GCGCAAGCCC TGCTGTTGTCGGCTCAAAAC TACGCCCGCG AACTGGAACA 201 GGCGCGTGCG GAAGCTAAAA AATATGAAGTCAAGGCGCAC GCCGTCGGCA 251 TGGCTTTGGC GAAAAAACAG GCGGAAGTCA GCCGTCTGAAAACGGAAAAT 301 AAAAAGGAAA TCGAAAATGT CCTTACTCAA GACCGTAAAA ATGCAGGCGG351 CGGTTGTATT GACGGCTTTG GCCATCACGG CTTGCAGCTC TACAAGCGCG 401CCCTCGGCTA CGGAAATTAAThis corresponds to the amino acid sequence <SEQ ID 2456; ORF 727.a>:

a727.pep 1 MNLVKLLANN WQPIAIIALV GTGLAVSHHQ GYKSAFAKQQ AVIEKMKRDK 51AQALLLSAQN YARELEQARA EAKKYEVKAH AVGMALAKKQ AEVSRLKTEN 101 KKEIENVLTQDRKNAGGGCI DGFGHHGLQL YKRALGYGN* a727/m727 83.2% identity in 119 aaoverlap           10        20        30        40        50        60a727.pep   MNLVKLLANNWQPIAIIALVGTGLAVSHHQGYKSAFAKQQAVIEKMKRDKAQALLLSAQN  |||||||||||||||||||||||||||||||||||||||||||:||:||||||||||||| m727  MNLVKLLANNWQPIAIIALVGTGLAVSHHQGYKSAFAKQQAVIDKMERDKAQALLLSAQN          10        20        30        40        50        60          70        80        90       100       110       119 a727.pep  YARELEQARAEAKKYEVKAHAVGMALAKKQAEVSRLKTENKKEIENV-LTQDRKNAGGGC  |||||| ||||||||||||||||||||||||||||||||  ::: :: :  | :| : | m727  YARELELARAEAKKYEVKAHAVGMALAKKQAEVSRLKTE--RDLCKIPFPPDSRNPNTGF          70        80        90       100       110120     130       140 a727.pep   IDGFGHHGLQLYKRALGYGNX m727  RLFSPQIPPNFTQIPPX  120      130The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2457>:

g728.seq 1 ATGTTTAAAA AATTCAAACC GGTACTGTTG TCATTTTTTG CACTTGTATT 51TGCCTTTTGG CTGGGAACAG GTATTGCCTA TGAGATTAAT CCGCGTTGGT 101 TTTTGAGCGATACGGCAACT GAAGTACCTG AAAATCCGAA TGCTTTTGTG 151 GCGAAACTTG CCCGCCTGTTCCGAAATGCC GACAGGGCGG TTGTCATCGT 201 GAAGGAATCG ATGAGGACGG AGGAAAGCCTTGCCGGAGCT GTGGATGACG 251 GTCCGTTGCA GTCGGAGAAG GATTATCTCG CGCTCGCTATCCGGCTCAGT 301 CGTTTGAAAG AAAAGGCGAA ATGGTTTCAC GTAACGGAGC AGGAACATGG351 GGAAGAGGTT TGGCTGGATT ACTATATCGG CGAGGGCGGT TTGGTTGCGG 401TTTCGCTTTC GCAACGCTCG CCGGAAGCGT TTGTTAATGC CGAATATCTG 451 TATCGGAACGATCGTCCGTT TTCTGTAAAT GTGTACGGCG GAACGGCTCA 501 CGGGGAAAAT TATGAAACGACAGGAGAATA TCGGGTTGTT TGGCAACCGG 551 ACGGTTCGGT ATTTGATGCG GCGGGGCGCGGGAAAATCGG GGAAGATGTT 601 TATGAGCATT GCCTCGGGTG TTATCAGATG GCCCAGGTATATTTGGCGAA 651 ATACCGGGAT GTCGCGAATG ACGAGCAGAA GGTTTGGGAC TTCCGCGAAG701 AGAGCAACCG GATTGCATCG GACTCGCGCG ATTATGTGTT TTATCAGAAT 751ATGCGGGAAT TGATGCCCCG GGGGATGAAG GCGAACAGTC TTGTGGTCGG 801 CTATGATGCGGACGGTCTGC CGCAAAAAGT CTATTGGAGT TTCGACAATG 851 GAAAAAAACG CCAGAGTTTCGAATATTATT TGAAAAACGG AAATCTTTTT 901 ATTGCACAAT CTTCGACGGT AGCATTGAAAGCGGATGGCG TAACGGCGGA 951 TATGCAGACC TATCATGCGC AACAGACGTG GTATTTGGATGGCGGGCGGA 1001 TTATCCGCGA AGAGAAACAG GGAGACAGAC TGCCTGATTT TCCTTTGAAC1051 TTGGAAGATT TGGAAAAAGA GGTGAGCCGT TATGCAGAGG CTGCGGCGAG 1101ACGTTCGGGC GGCAGGCGCG GCCTTTCTCA CTGAThis corresponds to the amino acid sequence <SEQ ID 2458; ORF 728>:

g728.pep 1 MFKKFKPVLL SFFALVFAFW LGTGIAYEIN PRWFLSDTAT EVPENPNAFV 51AKLARLFRNA DRAVVIVKES MRTEESLAGA VDDGPLQSEK DYLALAIRLS 101 RLKEKAKWFHVTEQEHGEEV WLDYYIGEGG LVAVSLSQRS PEAFVNAEYL 151 YRNDRPFSVN VYGGTAHGENYETTGEYRVV WQPDGSVFDA AGRGKIGEDV 201 YEHCLGCYQM AQVYLAKYRD VANDEQKVWDFREESNRIAS DSRDYVFYQN 251 MRELMPRGMK ANSLVVGYDA DGLPQKVYWS FDNGKKRQSFEYYLKNGNLF 301 IAQSSTVALK ADGVTADMQT YHAQQTWYLD GGRIIREEKQ GDRLPDFPLN351 LEDLEKEVSR YAEAAARRSG GRRGLSH*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2459>:

m728.seq 1 ATGTTTAAAA AATTCAAACC GGTACTGTTG TCATTTTTTG CACTTGTATT 51TGCCTTTTGG CTGGGAACGG GTATTGCCTA TGAGATTAAT CCGCGTTGGT 101 TTTTGAGCGATACGGCAACT GAAGTACCTA AAAATCCGAA TGCTTTTGTG 151 GCGAAACTTG CCCGCCTGTTCCGAAATGCC GACAGGGCGG TTGTCATCGT 201 GAAGGAATCG ATAAGGACGG AGGAAAATCTTGCCGGAACT GTGGATGACG 251 GTCCGTTGCA GTCGGAGAAG GATTATCTCG CGCTCGCTATCCGGCTCAGT 301 CGTTTGAAAG AAAAGGCGAA ATGGTTTCAC GTAACGGAGC AGGAACATGG351 GAAAGAGGTT TGGCTGGATT ACCATATCGG CGAGGGCGGT TTGGTTGCGG 401TTTCGCTTTC GCAACGCTCG CCGGAAGCAT TTGTTAATGC CGAATATCTG 451 TATCGGAACGATCGTCCGTT TTCTGTAAAT GTGTACGGCG GAACGGTTCA 501 CGGGGAAAAT TATGAAACGACAGGAGAATA TCGGGTTGTT TGGCAACCAG 551 ACGGTTCGGT ATTTGATGCG GCGGGGCGCGGGAAAATCGG GGAAGATGTT 601 TATGAGCATT GCCTCGGGTG TTATCAGATG GCCCAGGTATATTTGGCGAA 651 ATACCGGGAT GTCGCGAATG ACGAGCAGAA GGTTTGGGAC TTCCGCAAAG701 AGAGCAACCG AATTGCGTCG GACTCGCGCA ATTCTGTGTT TTATCAGAAT 751ATGCGGGAAT TGATGCCCCG AGGGATGAAG GCGAACAGTC TTGTGGTCGG 801 CTATGATGCGGACGGTCTGC CGCAAAAAGT CTATTGGAGT TTCGACAATG 851 GAAAAAAACG CCAGAGTTTCGAATATTATT TGAAAAACGG AAATCTTTTT 901 ATTGCACAAT CTTCGACGGT AGCATTGAAAGCGGATGGCG TAACGGCGGA 951 TATGCAGACC TATCATGCGC AACAGACGTG GTATTTGGATGGCGGGCGGA 1001 TTGTCCGCGA AGAGAAACAG GGAGACAGAC TGCCTGATTT TCCTTTGAAC1051 TTGGAAAATT TGGAAAAAGA GGTGCGCCGT TATGCAGAGG CTGCGGCGAG 1101ACGTTCGGGC GGCAGGCGCG ACCTTTCTCA CTGAThis corresponds to the amino acid sequence <SEQ ID 2460; ORF 728>:

m728.pep 1 MFKKFKPVLL SFFALVFAFW LGTGIAYEIN PRWFLSDTAT EVPKNPNAFV 51AKLARLFRNA DRAVVIVKES IRTEENLAGT VDDGPLQSEK DYLALAIRLS 101 RLKEKAKWFHVTEQEHGKEV WLDYHIGEGG LVAVSLSQRS PEAFVNAEYL 151 YRNDRPFSVN VYGGTVHGENYETTGEYRVV WQPDGSVFDA AGRGKIGEDV 201 YEHCLGCYQM AQVYLAKYRD VANDEQKVWDFRKESNRIAS DSRNSVFYQN 251 MRELMPRGMK ANSLVVGYDA DGLPQKVYWS FDNGKKRQSFEYYLKNGNLF 301 IAQSSTVALK ADGVTADMQT YHAQQTWYLD GGRIVREEKQ GDRLPDFPLN351 LENLEKEVRR YAEAAARRSG GRRDLSH*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 728 shows 96.3% identity over a 377 aa overlap with a predicted ORF(ORF728.a) from N. gonorrhoeae:

m728/g728         10        20        30        40        50        60m728.pep MFKKFKPVLLSFFALVFAFWLGTGIAYEINPRWFLSDTATEVPKNPNAFVAKLARLFRNA|||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||| g728MFKKFKPVLLSFFALVFAFWLGTGIAYEINPRWFLSDTATEVPENPNAFVAKLARLFRNA        10        20        30        40        50        60        70        80        90       100       110       120 m728.pepDRAVVIVKESIRTEENLAGTVDDGPLQSEKDYLALAIRLSRLKEKAKWFHVTEQEHGKEV||||||||||:||||:|||:|||||||||||||||||||||||||||||||||||||:|| g728DRAVVIVKESMRTEESLAGAVDDGPLQSEKDYLALAIRLSRLKEKAKWFHVTEQEHGEEV        70        80        90       100       110       120       130       140       150       160       170       180 m728.pepWLDYHIGEGGLVAVSLSQRSPEAFVNAEYLYRNDRPFSVNVYGGTVHGENYETTGEYRVV||||:||||||||||||||||||||||||||||||||||||||||:|||||||||||||| g728WLDYYIGEGGLVAVSLSQRSPEAFVNAEYLYRNDRPFSVNVYGGTAHGENYETTGEYRVV       130       140       150       160       170       180       190       200       210       220       230       240 m728.pepWQPDGSVFDAAGRGKIGEDVYEHCLGCYQMAQVYLAKYRDVANDEQKVWDFRKESNRIAS||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||| g728WQPDGSVFDAAGRGKIGEDVYEHCLGCYQMAQVYLAKYRDVANDEQKVWDFREESNRIAS       190       200       210       220       230       240       250       260       270       280       290       300 m728.pepDSRNSVFYQNMRELMPRGMKANSLVVGYDADGLPQKVYWSFDNGKKRQSFEYYLKNGNLF |||:|||||||||||||||||||||||||||||||||||||||||||||||||||||| g728DSRDYVFYQNMRELMPRGMKANSLVVGYDADGLPQKVYWSFDNGKKRQSFEYYLKNGNLF       250       260       270       280       290       300       310       320       330       340       350       360 m728.pepIAQSSTVALKADGVTADMQTYHAQQTWYLDGGRIVREEKQGDRLPDFPLNLENLEKEVRR||||||||||||||||||||||||||||||||||:|||||||||||||||||:||||| | g728IAQSSTVALKADGVTADMQTYHAQQTWYLDGGRIIREEKQGDRLPDFPLNLEDLEKEVSR       310       320       330       340       350       360        370m728.pep YAEAAARRSGGRRDLSHX ||||||||||||| |||| g728 YAEAAARRSG GRRGLSHX       370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2461>:

a728.seq 1 ATGTTTAAAA AATTCAAACC GGTACTGTTG TCATTTTTTG CACTTGTATT 51TGCCTTTTGG CTGGGAACGG GTATTGCCTA TGAGATTAAT CCGCGTTGGT 101 TTTTGAGCGATACGGCAACT GAAAATCCGA ATGCTTTTGT GGCGAAACTT 151 GCCCGCCTGT TCCGAAATGCCGACAGGGCG GTTGTCATCG TGAAGGAATC 201 GATGAGGACG GAGGAAAGTC TTGCCGGAGCTGTGGATGAC GGTCCGTTGC 251 AGTCGGAGAA GGATTATCTT GCACTCGCTG TCCGGCTCAGTCGTTTGAAA 301 GAAAAGGCGA AATGGTTTCA CGTAACGGAG CAGGAACATG GGGAAGAGGT351 TTGGCTGGAT TACTATATCG GCGAGGGCGG TTTGGTTGCG GTTTCGCTTT 401CGCAACGCTC GCCGGAAGCG TTTGTTAATG CCGAATATCT GTATCGGAAC 451 GATCGTCCGTTTTCTGTAAA TGTGTACGGC GGAACGGTTC ACGGGGAAAA 501 TTATGAAACG ACAGGAGAATATCGGGTTGT TTGGCAACCG GACGGTTCGG 551 TATTTGATGC GTCGGGGCGC GGGAAAATCGGGGAAGATGT TTATGAGCAT 601 TGCCTCGGGT GTTATCAGAT GGCCCAGGTA TATTTGGCGAAATATCGGGA 651 TGTCGCGAAT GATGAGCAGA AGGTTTGGGA CTTCCGCGAA GAGAGTAACC701 GGATTGCGTC GGACTCGCGC GATTCTGTGT TTTATCAGAA TATGCGGGAA 751TTGATGCCCC GAGGGATGAA GGCAAACAGT CTTGTGGTCG GCTATGATGC 801 GGACGGTCTGCCGCAGAAAG TCTATTGGAG TTTCGACAAT GGGAAAAAAC 851 GCCAGAGTTT CGAATATTATTTGAAAAACG GAAATCTTTT TATTGCACAA 901 TCTTCGACGG TAGCATTGAA AGCGGATGGCGTAACGGCGG ATATGCAGAC 951 CTATCATGCG CAACAGACGT GGTATTTAGA TGGCGGGCGGATTGTCCGCG 1001 AAGAGAAACA GGGGGACAGA CTGCCTGATT TTCCTTTGAA CTTGGAAGAT1051 TTGGAAAAAG AGGTGAGCCG TTATGCAGAG GCTGCGGCGA GACGTTCGGG 1101CGGCAGGCGC GACCTTTCTC ACTGAThis corresponds to the amino acid sequence <SEQ ID 2462; ORF 728.a>:

a728.pep 1 MFKKFKPVLL SFFALVFAFW LGTGIAYEIN PRWFLSDTAT ENPNAFVAKL 51ARLFRNADRA VVIVKESMRT EESLAGAVDD GPLQSEKDYL ALAVRLSRLK 101 EKAKWFHVTEQEHGEEVWLD YYIGEGGLVA VSLSQRSPEA FVNAEYLYRN 151 DRPFSVNVYG GTVHGENYETTGEYRVVWQP DGSVFDASGR GKIGEDVYEH 201 CLGCYQMAQV YLAKYRDVAN DEQKVWDFREESNRIASDSR DSVFYQNMRE 251 LMPRGMKANS LVVGYDADGL PQKVYWSFDN GKKRQSFEYYLKNGNLFIAQ 301 SSTVALKADG VTADMQTYHA QQTWYLDGGR IVREEKQGDR LPDFPLNLED351 LEKEVSRYAE AAARRSGGRR DLSH* a728/m728 96.3% identity in 377 aaoverlap         10        20        30        40           50 a728.pepMFKKFKPVLLSFFALVFAFWLGTGIAYEINPRWFLSDTATE---NPNAFVAKLARLFRNA|||||||||||||||||||||||||||||||||||||||||   |||||||||||||||| m728MFKKFKPVLLSFFALVFAFWLGTGIAYEINPRWFLSDTATEVPKNPNAFVAKLARLFRNA        10        20        30        40        50        60 60        70        80        90       100       110 a728.pepDRAVVIVKESMRTEESLAGAVDDGPLQSEKDYLALAVRLSRLKEKAKWFHVTEQEHGEEV||||||||||:||||:|||:||||||||||||||||:||||||||||||||||||||:|| m728DRAVVIVKESIRTEENLAGTVDDGPLQSEKDYLALAIRLSRLKEKAKWFHVTEQEHGKEV        70        80        90       100       110       120120       130       140       150       160       170 a728.pepWLDYYIGEGGLVAVSLSQRSPEAFVNAEYLYRNDRPFSVNVYGGTVHGENYETTGEYRVV||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||| m728WLDYHIGEGGLVAVSLSQRSPEAFVNAEYLYRNDRPFSVNVYGGTVHGENYETTGEYRVV       130       140       150       160       170       180180       190       200       210       220       230 a728.pepWQPDGSVFDASGRGKIGEDVYEHCLGCYQMAQVYLAKYRDVANDEQKVWDFREESNRIAS||||||||||:|||||||||||||||||||||||||||||||||||||||||:||||||| m728WQPDGSVFDAAGRGKIGEDVYEHCLGCYQMAQVYLAKYRDVANDEQKVWDFRKESNRIAS       190       200       210       220       230       240240       250       260       270       280       290 a728.pepDSRDSVFYQNMRELMPRGMKANSLVVGYDADGLPQKVYWSFDNGKKRQSFEYYLKNGNLF|||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||| m728DSRNSVFYQNMRELMPRGMKANSLVVGYDADGLPQKVYWSFDNGKKRQSFEYYLKNGNLF       250       260       270       280       290       300300       310       320       330       340       350 a728.pepIAQSSTVALKADGVTADMQTYHAQQTWYLDGGRIVREEKQGDRLPDFPLNLEDLEKEVSR||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| | m728IAQSSTVALKADGVTADMQTYHAQQTWYLDGGRIVREEKQGDRLPDFPLNLENLEKEVRR       310       320       330       340       350       360360       370 a728.pep YAEAAARRSGGRRDLSHX |||||||||||||||||| m728YAEAAARRSGGRRDLSHX        370The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2463>:

g729.seq 1 ATGAATACTA CATTGAAAAC TACCTTGACC TCTGTTGCAG CAGCCTTTGC 51ATTGTCTGCC TGCACCATGA TTCCTCAATA CGAGCAGCCC AAAGTCGAAG 101 TTGCGGAAACCTTCCAAAAC GACACATCGG TTTCTTCCAT CCGCGCGGTT 151 GATTTGGGTT GGCATGACTATTTTGCCGAC CCGCGCCTGC AAAAGCTGAT 201 CGACATCGCA CTCGAGCGCA ATACCAGTTTGCGTACAGCC GTATTGAACA 251 GCGAAATCTA CCGCAAACAA TACATGATCG AGCGCAACAACCTCCTGCCC 301 ACGCTTGCCG CCAATGCGAA CGGCTCGCGC CAAGGCAGCT TGAGCGGCgg351 caaTGTCAGC AGCAGCTACA ATGTCGGACT GGGTGcGGca tCTTACGAAC 401TCGATCTGTT CgGGCGCGTG CGCagcaacA GcgaagcAGC ACTGcaggGC 451 tATTTTGCCAGCGTTGCCAA CcgcGATGCG GCACATTTGa ttCtGATTGC 501 CACCGTTGCC AAAGCCTATTTCAAcgaGcG TTATGCCGAA AAAGcgatgT 551 CTTTGGCGCa gcGTGTCTTG AAAACGCGCGAGGAAACCTA CAAGCTGTCC 601 GAATTGCGGT ACAAGGCAGG CGTGATTTCC GCCGTCGCCCTGCGCCAGCA 651 GGAAGCCTTG ATTGAATCTG CCAAAGCCGA TTATGCCCAT GCCGCGCGCa701 gcCGCGAACA GGCGCGCAAT GCCTTGGCAA CCTTGATTAA ccGTCCGATA 751CCCGAagaCC TGCCCGCCGG TTTGCCGTTG GACAagcAGT TTTTTGTTGA 801 AAAACTGCCTGCCGGTTTGA GTTCCGAAGT ATTGCTCGAC CGTCCCGACA 851 TCCGCGCCGC CGAACACGCGCTCAAACAGG CAAACGCCAA TATCGGTGCG 901 gcgCGCGCCg ccTTTTTCCC GTCCATCCGCCTGACCGGAA GCGTCGGTAC 951 GGGTTCTGTC GAATTGGGCG GGCTGTTCAA AAGCGGCACGGGCGTTTGGG 1001 CGTTCGCTCC GTCTATTACC CTGCCGATTT TTACTTGGGG AACGAACAAG1051 GCGAACCTTG ATGTGGCAAA ACTGCGCCAA CAGGCACAAA TTGTTGCCTA 1101TGAATCCGCC GTCCAATCCG CCTTTCAAGA CGTGGCAAAC GCATTGGCGG 1151 CGCGCGAGCAGCTGGATAAA GCCTATGACG CTTTAAGCAA ACAAAGCCGC 1201 GCCTCTAAAG AAGCGTTGCGCTTGGTCGGA CTGCGTTACA AACACGGCGT 1251 ATCCGGCGCG CTCGATTTGC TCGATGCGGAACGCATCAGC TATTCGGCGG 1301 AAGGTGCGGC TTTGTCGGCA CAACTGACCC GCGCCGAAAACCTTGCCGAT 1351 TTGTACAAGG CGCTCgacGG CGGATTGAAA CGGGATACCC AAACCGGCAA1401 ATAAThis corresponds to the amino acid sequence <SEQ ID 2464; ORF 729>:

g729.pep 1 MNTTLKTTLT SVAAAFALSA CTMIPQYEQP KVEVAETFQN DTSVSSIRAV 51DLGWHDYFAD PRLQKLIDIA LERNTSLRTA VLNSEIYRKQ YMIERNNLLP 101 TLAANANGSRQGSLSGGNVS SSYNVGLGAA SYELDLFGRV RSNSEAALQG 151 YFASVANRDA AHLILIATVAKAYFNERYAE KAMSLAQRVL KTREETYKLS 201 ELRYKAGVIS AVALRQQEAL IESAKADYAHAARSREQARN ALATLINRPI 251 PEDLPAGLPL DKQFFVEKLP AGLSSEVLLD RPDIRAAEHALKQANANIGA 301 ARAAFFPSIR LTGSVGTGSV ELGGLFKSGT GVWAFAPSIT LPIFTWGTNK351 ANLDVAKLRQ QAQIVAYESA VQSAFQDVAN ALAAREQLDK AYDALSKQSR 401ASKEALRLVG LRYKHGVSGA LDLLDAERIS YSAEGAALSA QLTRAENLAD 451 LYKALDGGLKRDTQTGK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2465>:

m729.seq 1 ATGGATACTA CATTGAAAAC CACCTTGACT TCTGTTGCAG CAGCCTTTGC 51ATTGTCTGCC TGCACCATGA TTCCCCAATA CGAGCAGCCC AAAGTCGAAG 101 TTGCCGAAACGTTCAAAAAC GATACCGCCG ACAGCGGCAT CCGCGCCGTC 151 GATTTAGGTT GGCATGACTATTTTGCCGAC CCGCGCCTGC AAAAGCTGAT 201 CGACATCGCA CTCGAGCGCA ATACCAGTTTGCGTACCGCC GTATTGAACA 251 GCGAAATCTA CCGCAAACAA TACATGATTG AGCGCAACAACCTCCTGCCC 301 ACGCTTGCCG CCAATGCGAA CGACTCGCGC CAAGGCAGCT TGAGCGGCGG351 CAATGTAAGC AGCAGCTACA AAGTCGGACT GGGTGCGGCA TCTTACGAAC 401TCGATCTGTT CGGGCGTGTA CGCAGCAGCA GCGAGGCGGC ACTGCAAGGC 451 TATTTCGCCAGCACCGCCAA CCGCGATGCG GCACATTTGA GCCTGATTGC 501 CACCGTTGCC AAAGCCTATTTCAACGAACG TTACGCCGAA GAAGCGATGT 551 CTTTGGCGCA ACGTGTTTTG AAAACGCGCGAGGAAACCTA CAAGCTGTCC 601 GAATTACGTT ACAAGGCAGG CGTGATTTCC GCCGTCGCCCTACGTCAGCA 651 GGAAGCCCTG ATCGAATCTG CCAAAGCCGA TTATGCCCAT GCCGCGCGCA701 GCCGCGAACA GGCGCGCAAT GCCTTGGCAA CCTTGATTAA CCAACCGATA 751CCCGAAGACC TGCCTGCCGG TTTGCCGCTG GACAAGCAGT TTTTTGTTGA 801 AAAACTGCCGGCCGGTTTGA GTTCCGAAGT ATTGCTCGAC CGTCCCGATA 851 TCCGTGCTGC CGAACACGCGCTCAAACAGG CAAACGCCAA TATCGGTGCG 901 GCACGCGCCG CCTTTTTCCC ATCCATCCGCCTGACCGGAA CCGTCGGTAC 951 GGGTTCTGCC GAATTGGGTG GGTTGTTCAA AAGCGGCACGGGCGTTTGGT 1001 CGTTCGCGCC GTCTATTACC CTGCCGATTT TTACCTGGGG TACGAACAAG1051 GCGAACCTTG ATGTAGCCAA GCTGCGCCAA CAGGTACAAA TCGTTGCCTA 1101TGAATCCGCC GTCCAATCCG CATTTCAAGA CGTGGCAAAC GCATTGGCGG 1151 CGCGCGAGCAGCTGGATAAA GCCTATGACG CTTTAAGCAA ACAAAGCCGC 1201 GCCTCTAAAG AAGCGTTGCGCTTGGTCGGC CTGCGTTACA AGCACGGCGT 1251 ATCCGGCGCG CTCGACTTGC TCGATGCGGAACGCAGCAGC TATGCGGCGG 1301 AGGGTGCGGC TTTGTCGGCA CAACTGACCC GCGCCGAAAACCTTGCCGAT 1351 TTGTACAAGG CACTCGGCGG CGGATTGAAA CGGGATACCC AAACCGACAA1401 ATAAThis corresponds to the amino acid sequence <SEQ ID 2466; ORF 729>:

m729.pep 1 MDTTLKTTLT SVAAAFALSA CTMIPQYEQP KVEVAETFKN DTADSGIRAV 51DLGWHDYFAD PRLQKLIDIA LERNTSLRTA VLNSEIYRKQ YMIERNNLLP 101 TLAANANDSRQGSLSGGNVS SSYKVGLGAA SYELDLFGRV RSSSEAALQG 151 YFASTANRDA AHLSLIATVAKAYFNERYAE EAMSLAQRVL KTREETYKLS 201 ELRYKAGVIS AVALRQQEAL IESAKADYAHAARSREQARN ALATLINQPI 251 PEDLPAGLPL DKQFFVEKLP AGLSSEVLLD RPDIRAAEHALKQANANIGA 301 ARAAFFPSIR LTGTVGTGSA ELGGLFKSGT GVWSFAPSIT LPIFTWGTNK351 ANLDVAKLRQ QVQIVAYESA VQSAFQDVAN ALAAREQLDK AYDALSKQSR 401ASKEALRLVG LRYKHGVSGA LDLLDAERSS YAAEGAALSA QLTRAENLAD 451 LYKALGGGLKRDTQTDK*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 729 shows 95.7% identity over a 467 aa overlap with a predicted ORF(ORF729.a) from N. gonorrhoeae:

m729/g729 95.7% identity in 467 aa overlap        10        20        30        40        50        60 m729.pepMDTTLKTTLTSVAAAFALSACTMIPQYEQPKVEVAETFKNDTADSGIRAVDLGWHDYFAD|:||||||||||||||||||||||||||||||||||||:|||: |:|||||||||||||| g729MNTTLKTTLTSVAAAFALSACTMIPQYEQPKVEVAETFQNDTSVSSIRAVDLGWHDYFAD        10        20        30        40        50        60        70        80        90       100       110       120 m729.pepPRLQKLIDIALERNTSLRTAVLNSEIYRKQYMIERNNLLPTLAANANDSRQGSLSGGNVS|||||||||||||||||||||||||||||||||||||||||||||| ||||||||||||| g729PRLQKLIDIALERNTSLRTAVLNSEIYRKQYMIERNNLLPTLAANANGSRQGSLSGGNVS        70        80        90       100       110       120       130       140       150       160       170       180 m729.pepSSYKVGLGAASYELDLFGRVRSSSEAALQGYFASTANRDAAHLSLIATVAKAYFNERYAE|||:||||||||||||||||||:|||||||||||:|||||||| |||||||||||||||| g729SSYNVGLGAASYELDLFGRVRSNSEAALQGYFASVANRDAAHLILIATVAKAYFNERYAE       130       140       150       160       170       180       190       200       210       220       230       240 m729.pepEAMSLAQRVLKTREETYKLSELRYKAGVISAVALRQQEALIESAKADYAHAARSREQARN:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g729KAMSLAQRVLKTREETYKLSELRYKAGVISAVALRQQEALIESAKADYAHAARSREQARN       190       200       210       220       230       240       250       260       270       280       290       300 m729.pepALATLINQPIPEDLPAGLPLDKQFFVEKLPAGLSSEVLLDRPDIRAAEHALKQANANIGA|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||| g729ALATLINRPIPEDLPAGLPLDKQFFVEKLPAGLSSEVLLDRPDIRAAEHALKQANANIGA       250       260       270       280       290       300       310       320       330       340       350       360 m729.pepARAAFFPSIRLTGTVGTGSAELGGLFKSGTGVWSFAPSITLPIFTWGTNKANLDVAKLRQ|||||||||||||:|||||:|||||||||||||:|||||||||||||||||||||||||| g729ARAAFFPSIRLTGSVGTGSVELGGLFKSGTGVWAFAPSITLPIFTWGTNKANLDVAKLRQ       310       320       330       340       350       360       370       380       390       400       410       420 m729.pepQVQIVAYESAVQSAFQDVANALAAREQLDKAYDALSKQSRASKEALRLVGLRYKHGVSGA|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g729QAQIVAYESAVQSAFQDVANALAAREQLDKAYDALSKQSRASKEALRLVGLRYKHGVSGA       370       380       390       400       410       420       430       440       450       460 m729.pepLDLLDAERSSYAAEGAALSAQLTRAENLADLYKALGGGLKRDTQTDKX|||||||| ||:||||||||||||||||||||||| ||||||||| || g729LDLLDAERISYSAEGAALSAQLTRAENLADLYKALDGGLKRDTQTGKX       430       440       450       460The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2467>:

a729.seq 1 ATGGATACTA CATTGAAAAC CACCTTGACT TCTGTTGCAG CAGCCTTCGC 51ATTATCCGCC TGCACCATGA TTCCCCAATA CGAGCAGCCC AAAGTCGAAG 101 TTGCCGAAACGTTCAAAAAC GATACCGCCG ACAGCGGCAT CCGTGCGGTC 151 GATTTGGGTT GGCATGACTATTTTGCCGAC CCGCGCCTGC AAAAGCTGAT 201 CGACATCGCA CTCGAGCGCA ATACCAGTTTGCGTACCGCC GTATTGAACA 251 GCGAAATCTA CCGCAAACAA TACATGATTG AGCGCAACAACCTCCTGCCC 301 ACGCTTGCCG CCAATGCGAA CGACTCGCGC CAAGGCAGCT TGAGCGGCGG351 CAATGTAAGC AGCAGCTACA AAGTCGGACT GGGTGCGGCA TCTTACGAAC 401TCGATCTGTT CGGGCGTGTA CGCAGCAGCA GCGAGGCGGC ACTGCAAGGC 451 TATTTCGCCAGCACCGCCAA CCGCGATGCG GCACATTTGA GCCTGATTGC 501 CACCGTTGCC AAAGCCTATTTCAACGAACG TTATGCCGAA GAAGCGATGT 551 CTTTGGCGCA ACGTGTTTTG AAAACGCGCGAGGAAACCTA CAAGCTGTCC 601 GAATTACGTT ACAAGGCAGG CGTGATTTCC GCCGTCGCCCTACGTCAGCA 651 GGAAGCCCTA ATCGAATCTG CCAAAGCCGA TTATGCCCAT GCCGCGCGCA701 GCCGCGAACA GGCGCGCAAT GCCTTGGCAA CCCTGATTAA CCAACCGATA 751CCCGACGACC TGCCCGCCGG TTTGCCGTTG GACAAGCAGT TTTTTGTTGA 801 GAAGCTGCCGGCCGGTTTGA GTTCCGAAGT ATTGCTCGAC CGTCCCGATA 851 TCCGTGCTGC CGAACACGCGCTCAAACAGG CAAACGCCAA TATCGGTGCG 901 GCACGCGCCG CCTTTTTCCC ATCCATCCGCCTGACCGGAA GCGTCGATAC 951 GCATTCTGCC GAATTGGGCG GGCTGTTCAA AAGCGGCACCGGCGTTTGGT 1001 TGTTCGCACC TTCCATTACC CTGCCGATTT TTACCTGGGG TACGAACAAG1051 GCGAACCTCG ATGTAGCCAA GCTGCGCCAA CAGGCACAAA TCGTTGCCTA 1101TGAAGCCGCC GTCCAATCCG CATTTCAAGA CGTGGCAAAC GCATTGACCG 1151 CGCGCGAGCAGTTGGATAAA GCCTATGACG CTTTAAGCAA ACAAAGCCGC 1201 GCCTCTAAAG AAGCGTTGCGTTTGGTCGGT CTGCGTTACA AACACGGCGT 1251 ATCCGGCGCG CTCGACTTGC TCGATGCGGAACGCAGCAGC TATTCGGCGG 1301 AAGGTGCGGC TTTGTCGGCA CAACTGACCC GCGCCGAAAACCTTGCCGAT 1351 TTGTACAAGG CACTCGGCGG CGGATTGAAA CGGGATACCC AAACCGACAA1401 ATAAThis corresponds to the amino acid sequence <SEQ ID 2468; ORF 729.a>:

a729.pep 1 MDTTLKTTLT SVAAAFALSA CTMIPQYEQP KVEVAETFKN DTADSGIRAV 51DLGWHDYFAD PRLQKLIDIA LERNTSLRTA VLNSEIYRKQ YMIERNNLLP 101 TLAANANDSRQGSLSGGNVS SSYKVGLGAA SYELDLFGRV RSSSEAALQG 151 YFASTANRDA AHLSLIATVAKAYFNERYAE EAMSLAQRVL KTREETYKLS 201 ELRYKAGVIS AVALRQQEAL IESAKADYAHAARSREQARN ALATLINQPI 251 PDDLPAGLPL DKQFFVEKLP AGLSSEVLLD RPDIRAAEHALKQANANIGA 301 ARAAFFPSIR LTGSVDTHSA ELGGLFKSGT GVWLFAPSIT LPIFTWGTNK351 ANLDVAKLRQ QAQIVAYEAA VQSAFQDVAN ALTAREQLDK AYDALSKQSR 401ASKEALRLVG LRYKHGVSGA LDLLDAERSS YSAEGAALSA QLTRAENLAD 451 LYKALGGGLKRDTQTDK* a729/m729 98.1% identity in 467 aa overlap        10        20        30        40        50        60 a729.pepMDTTLKTTLTSVAAAFALSACTMIPQYEQPKVEVAETFKNDTADSGIRAVDLGWHDYFAD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m729MDTTLKTTLTSVAAAFALSACTMIPQYEQPKVEVAETFKNDTADSGIRAVDLGWHDYFAD        10        20        30        40        50        60        70        80        90       100       110       120 a729.pepPRLQKLIDIALERNTSLRTAVLNSEIYRKQYMIERNNLLPTLAANANDSRQGSLSGGNVS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m729PRLQKLIDIALERNTSLRTAVLNSEIYRKQYMIERNNLLPTLAANANDSRQGSLSGGNVS        70        80        90       100       110       120       130       140       150       160       170       180 a729.pepSSYKVGLGAASYELDLFGRVRSSSEAALQGYFASTANRDAAHLSLIATVAKAYFNERYAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m729SSYKVGLGAASYELDLFGRVRSSSEAALQGYFASTANRDAAHLSLIATVAKAYFNERYAE       130       140       150       160       170       180       190       200       210       220       230       240 a729.pepEAMSLAQRVLKTREETYKLSELRYKAGVISAVALRQQEALIESAKADYAHAARSREQARN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m729EAMSLAQRVLKTREETYKLSELRYKAGVISAVALRQQEALIESAKADYAHAARSREQARN       190       200       210       220       230       240       250       260       270       280       290       300 a729.pepALATLINQPIPDDLPAGLPLDKQFFVEKLPAGLSSEVLLDRPDIRAAEHALKQANANIGA|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||| m729ALATLINQPIPEDLPAGLPLDKQFFVEKLPAGLSSEVLLDRPDIRAAEHALKQANANIGA       250       260       270       280       290       300       310       320       330       340       350       360 a729.pepARAAFFPSIRLTGSVDTHSAELGGLFKSGTGVWLFAPSITLPIFTWGTNKANLDVAKLRQ|||||||||||||:| | ||||||||||||||| |||||||||||||||||||||||||| m729ARAAFFPSIRLTGTVGTGSAELGGLFKSGTGVWSFAPSITLPIFTWGTNKANLDVAKLRQ       310       320       330       340       350       360       370       380       390       400       410       420 a729.pepQAQIVAYEAAVQSAFQDVANALTAREQLDKAYDALSKQSRASKEALRLVGLRYKHGVSGA|:||||||:|||||||||||||:||||||||||||||||||||||||||||||||||||| m729QVQIVAYESAVQSAFQDVANALAAREQLDKAYDALSKQSRASKEALRLVGLRYKHGVSGA       370       380       390       400       410       420       430       440       450       460 a729.pepLDLLDAERSSYSAEGAALSAQLTRAENLADLYKALGGGLKRDTQTDKX|||||||||||:|||||||||||||||||||||||||||||||||||| m729LDLLDAERSSYAAEGAALSAQLTRAENLADLYKALGGGLKRDTQTDKX       430       440       450       460The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2469>:

g730.seq 1 GTGAAACCGC TGCGCAGACT GACAAACCTC CTTGCCGCCT GCGCCGTAGC 51GGCGGTCGCA CTCATACAGC CCGCCCTCGC GGCGGACTTG GCGCAAGACC 101 CGTTCATTACCGATAACACC CAACGGCAGC ACTACGAACC CGGCGGCAAA 151 TACCACCTCT TCGGcgaCCCGCGCGGCAGC GTTTCCGACC GCACCGGCAA 201 AATCAACGTC ATCCAAGACT ATACCCACCAGATGGGCAAC CTGCTCATCC 251 AACAGGCGGC AATCCAAGGC AATCTTGGTT ACACCGTCCGCTTTTCCGGA 301 CACGGACACG AAGAACACGC CCCCTTCGAC AACCACGCCG CCGACAGCGC351 AAGCGAAGAA AAAGGCAACG TTGACGACGG CTTTACCGTG TACCGGCTCA 401ACTGGGAAGG ACACGAACAT CATCCCGCCG ATGCCTACGA CGGCCCGAAG 451 GGCGGCAATTACCCCAAACC TACGGGCGCA CGAGACGAAT ACACCTATCA 501 CGTCAACGGC ACAGCCCGCAGTATCAAACT CAATCCGACC GACACCCGCA 551 GCATCCGGCA ACGCATATTC GACAACTACAACAACCTCGG CAGCAATTTC 601 TCCGACCGCG CCGATGAAGC CAACAGAAAA ATGTTCGAGCACAATGCCAA 651 GCTCGACCGC TGGGGCAACA GCATGGAGTT TGTCAACGGC GTCGCCGCCG701 GCGCGCTCAA CCCCTTTATC AGCGCGGGCG AAGCCTTGGG CATAGGCGAC 751ATACTGTACG GAACGCGCTA TGCCATAGAC AAAGCCGCGA TGCGCAACAT 801 CGCCCCCTTACCCGCCGAGG GCAAATTCGC CGCCATCGGC GGCTTGGGCA 851 GCGCGGCGGG CTTTGAAAAAAATACGCGCG AAGCCGTTGA CCGGTGGATA 901 CAGGAAAACC CCAATGCCGC CGAAACCGTCGAAGCCCTGG TCAACGTCCT 951 GCCGTTTGCC AAAGTCAAAA ACCTGACAAA GGCGGCAAAACCGGGGAAGG 1001 CTGCGGTTAG TGGGGATTTT TCTAAATCCT ACACCTGCTC CTTCCACGGC1051 AGCACCTTGG TCAAAACGGC AGACGGCTAC AAAGCCATTG CCCATATTCA 1101AGCCGGAGAC CGCGTCCTTT CCAAGGACGA GGCAAGCGGA GAAACGGGAT 1151 ACAAACCCGTTACCGCCCGA TACGGCAATC CGTATCAAGA AACCGTTTAC 1201 ATTGAAGTTT CAGACGGCATCGGCAACAGC CAAACCCTGA TTTCCAACCG 1251 CATCCACCCG TTTTATTCGG ACGGCAAATGGATTAAGGCG GAAGATTTAA 1301 AAGCGGGAAG CCGGCTGTTA TCCGAAAGCG GCAAAACCCAAACCGTCCGC 1351 AACATCGTTG TCAAACCAAA ACCGCTCAAA GCCTACAATC TGACCGTTGC1401 CGATTGGCAT ACCTACTTCG TCAAGGGTAA TCAGGCGGAA ACGGAAGGGG 1451TTTGGGTTCA TAATGATTGT CCGCCTAAAC CAAAACCAAC CAATCATGCC 1501 CAACAAAGAAAAGAAGAAGC TAAAAACGAT TCTCATCGAA GTGTGGGAGA 1551 TTCCAATCGT GTCGTTCGCGAAGGAAAGCA ATATTTAGAT TCCGACACAG 1601 GAAACCATGT TTATGTAAAA GGAGATAAAGTGGTTATTCT AACTCCTGAT 1651 GGAAGACAGG TAACTCAATT TAAGAACTCG AAAGCCAATACGTCAAAAAG 1701 GGTAAAAAAT GGGAAATGGA CACCAAAATA AThis corresponds to the amino acid sequence <SEQ ID 2470; ORF 730.ng>:

g730.pep 1 VKPLRRLTNL LAACAVAAVA LIQPALAADL AQDPFITDNT QRQHYEPGGK 51YHLFGDPRGS VSDRTGKINV IQDYTHQMGN LLIQQAAIQG NLGYTVRFSG 101 HGHEEHAPFDNHAADSASEE KGNVDDGFTV YRLNWEGHEH HPADAYDGPK 151 GGNYPKPTGA RDEYTYHVNGTARSIKLNPT DTRSIRQRIF DNYNNLGSNF 201 SDRADEANRK MFEHNAKLDR WGNSMEFVNGVAAGALNPFI SAGEALGIGD 251 ILYGTRYAID KAAMRNIAPL PAEGKFAAIG GLGSAAGFEKNTREAVDRWI 301 QENPNAAETV EALVNVLPFA KVKNLTKAAK PGKAAVSGDF SKSYTCSFHG351 STLVKTADGY KAIAHIQAGD RVLSKDEASG ETGYKPVTAR YGNPYQETVY 401IEVSDGIGNS QTLISNRIHP FYSDGKWIKA EDLKAGSRLL SESGKTQTVR 451 NIVVKPKPLKAYNLTVADWH TYFVKGNQAE TEGVWVHNDC PPKPKPTNHA 501 QQRKEEAKND SHRSVGDSNRVVREGKQYLD SDTGNHVYVK GDKVVILTPD 551 GRQVTQFKNS KANTSKRVKN GKWTPK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2471>:

m730.seq 1 GTGAAACCGC TGCGCAGACT GACAAACCTC CTTGCCGCCT GCGCCGTAGC 51GGCGGCCGCA CTCATACAGC CCGCCCTCGC GGCGGACTTG GCGCAAGACC 101 CGTTCATTACCGATAACGCC CAACGGCAGC ACTACGAACC CGGCGGCAAA 151 TACCACCTCT TCGGCGACCCGCGCGGCAGC GTTTCCGACC GCACCGGCAA 201 AATCAACGTC ATCCAAGACT ATACCCACCAGATGGGCAAC CTGCTCATCC 251 AACAGGCAAA CATCAACGGC ACAATCGGCT ACCACACCCGCTTTTCCGGA 301 CACGGACACG AAGAACACGC CCCCTTCGAC AACCACGCCG CCGACAGCGC351 GAGCGAAGAA AAAGGCAACG TTGACGAAGG CTTTACCGTA TACCGGCTCA 401ACTGGGAAGG ACACGAACAT CATCCCGCCG ATGCCTACGA CGGCCCGAAG 451 GGCGGCAATTACCCCAAACC TACGGGCGCA CGAGACGAAT ACACCTATCA 501 CGTCAACGGC ACAGCCCGCAGTATCAAACT CAATCCGACC GACACCCGCA 551 GCATCCGGCA ACGCATATCC GACAATTACAGCAACCTCGG CAGCAATTTC 601 TCCGACCGCG CCGATGAAGC CAACAGAAAA ATGTTCGAGCACAATGCCAA 651 GCTCGACCGC TGGGGCAACA GCATGGAGTT TATCAACGGC GTCGCCGCCG701 GCGCGCTCAA CCCCTTTATC AGCGCGGGCG AAGCCTTGGG CATAGGCGAC 751ATACTGTACG GAACGCGCTA TGCCATAGAC AAAGCCGCAA TGCGCAACAT 801 CGCCCCCTTGCCCGCCGAGG GCAAATTCGC CGTCATCGGC GGCTTGGGCA 851 GCGTGGCGGG CTTTGAAAAGAATACGCGCG AAGCCGTTGA CCGGTGGATA 901 CAGGAAAATC CCAATGCCGC CGAAACCGTCGAAGCCGTCT TCAACGTTGC 951 CGCAGCAGCC AAAGTCGCGA AGTTGGCAAA GGCGGCAAAACCAGGGAAGG 1001 CTGCGGTTAG CGGGGATTTT GCTGATTCTT ATAAAAAGAA ATTGGCTTTG1051 TCTGATAGTG CGAGACAGTT ATATCAAAAT GCAAAGTATA GAGAAGCTCT 1101AGATATACAT TATGAAGATT TAATTAGAAG AAAAACTGAT GGTTCATCAA 1151 AATTTATTAACGGCAGAGAA ATTGACGCTG TTACGAATGA TGCTTTAATA 1201 CAAGCCAAAA GAACAATTTCAGCAATAGAT AAACCTAAAA ATTTCTTAAA 1251 TCAAAAAAAT AGAAAGCAAA TTAAAGCAACCATCGAAGCA GCAAACCAAC 1301 AGGGAAAACG TGCAGAATTT TGGTTTAAAT ACGGTGTTCATTCACAAGTT 1351 AAGTCATATA TTGAATCAAA AGGCGGCATT GTTAAAACAG GTTTAGGAGA1401 TTAAThis corresponds to the amino acid sequence <SEQ ID 2472; ORF 730>:

m730.pep 1 VKPLRRLTNL LAACAVAAAA LIQPALAADL AQDPFITDNA QRQHYEPGGK 51YHLFGDPRGS VSDRTGKINV IQDYTHQMGN LLIQQANING TIGYHTRFSG 101 HGHEEHAPFDNHAADSASEE KGNVDEGFTV YRLNWEGHEH HPADAYDGPK 151 GGNYPKPTGA RDEYTYHVNGTARSIKLNPT DTRSIRQRIS DNYSNLGSNF 201 SDRADEANRK MFEHNAKLDR WGNSMEFINGVAAGALNPFI SAGEALGIGD 251 ILYGTRYAID KAAMRNIAPL PAEGKFAVIG GLGSVAGFEKNTREAVDRWI 301 QENPNAAETV EAVFNVAAAA KVAKLAKAAK PGKAAVSGDF ADSYKKKLAL351 SDSARQLYQN AKYREALDIH YEDLIRRKTD GSSKFINGRE IDAVTNDALI 401QAKRTISAID KPKNFLNQKN RKQIKATIEA ANQQGKRAEF WFKYGVHSQV 451 KSYIESKGGIVKTGLGD* g730/m730 93.0% identity in 344 aa overlap        10        20        30        40        50        60 g730.pepVKPLRRLTNLLAACAVAAVALIQPALAADLAQDPFITDNTQRQHYEPGGKYHLFGDPRGS||||||||||||||||||:||||||||||||||||||||:|||||||||||||||||||| m730VKPLRRLTNLLAACAVAAAALIQPALAADLAQDPFITDNAQRQHYEPGGKYHLFGDPRGS        10        20        30        40        50        60        70        80        90       100       110       120 g730.pepVSDRTGKINVIQDYTHQMGNLLIQQAAIQGNLGYTVRFSGHGHEEHAPFDNHAADSASEE|||||||||||||||||||||||||| |:|::|| :|||||||||||||||||||||||| m730VSDRTGKINVIQDYTHQMGNLLIQQANINGTIGYHTRFSGHGHEEHAPFDNHAADSASEE        70        80        90       100       110       120       130       140       150       160       170       180 g730.pepKGNVDDGFTVYRLNWEGHEHHPADAYDGPKGGNYPKPTGARDEYTYHVNGTARSIKLNPT|||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||| m730KGNVDEGFTVYRLNWEGHEHHPADAYDGPKGGNYPKPTGARDEYTYHVNGTARSIKLNPT       130       140       150       160       170       180       190       200       210       220       230       240 g730.pepDTRSIRQRIFDNYNNLGSNFSDRADEANRKMFEHNAKLDRWGNSMEFVNGVAAGALNPFI||||||||| |||:|||||||||||||||||||||||||||||||||:|||||||||||| m730DTRSIRQRISDNYSNLGSNFSDRADEANRKMFEHNAKLDRWGNSMEFINGVAAGALNPFI       190       200       210       220       230       240       250       260       270       280       290       300 g730.pepSAGEALGIGDILYGTRYAIDKAAMRNIAPLPAEGKFAAIGGLGSAAGFEKNTREAVDRWI|||||||||||||||||||||||||||||||||||||:||||||:||||||||||||||| m730SAGEALGIGDILYGTRYAIDKAAMRNIAPLPAEGKFAVIGGLGSVAGFEKNTREAVDRWI       250       260       270       280       290       300       310       320       330       340       350       360 g730.pepQENPNAAETVEALVNVLPFAKVKNLTKAAKPGKAAVSGDFSKSYTCSFHGSTLVKTADGY||||||||||||: ||   ||| :|:||||||||||||||: || m730QENPNAAETVEAVFNVAAAAKVAKLAKAAKPGKAAVSGDFADSYKKKLALSDSARQLYQN       310       320       330       340       350       360       370       380       390       400       410       420 g730.pepKAIAHIQAGDRVLSKDEASGETGYKPVTARYGNPYQETVYIEVSDGIGNSQTLISNRIHP m730AKYREALDIHYEDLIRRKTDGSSKFINGREIDAVTNDALIQAKRTISAIDKPKNFLNQKN       370       380       390       400       410       420The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2473>:

a730.seq 1 GTGAAACCGC TGCGAAGACT CATCAAGCTC CTTGCCGCCT GTGCCGTAGC 51GGCGGCCGCA CTCATACAGC CCGCCCTCGC GGCGGACTTG GCGCAAGACC 101 CGTTCATTACCGATAACGCC CAACGGCAGC ACTACGAACC CGGAGGCAAA 151 TACCACCTCT TCGGCGACCCGCGCGGCAGC GTCTCCGACC GCACCGGTCA 201 AATCAACGTC ATCCAAGACT ATACCCACCGGATGGGCAAC CTGCTCATCC 251 AGCAGGCAAA CATCAACGGC ACAATCGGCT ACCACACCCGCTTTTCCGGA 301 CACGGATACG AAGAACACGC CCCCTTCGAC AACCACGCCG CCGACAGCGC351 GAGCGAAGAA AAAGGCAACG TTGACGAAGG CTTTACCGTA TACCGGCTCA 401ACTGGGAAGG ACACGAACAT CATCCCGCCG ATGCCTACGA CGGCCCGAAG 451 GGCGGCAATTACCCCAAACC TACGGGTGCA CGCGACGAAT ACACCTATCA 501 CGTCAACGGC ACAGCACGCAGCATCAAACT CAATCCGACC GACACCCGCA 551 GCATCCGGCA ACGCATATCC GACAATTACAGCAACCTCGG CAGCAATTTC 601 TCCGACCGCG CCGATGAAGC CAACAGAAAA ATGTTCGAGCACAATGCCAA 651 GCTCGACCGC TGGGGCAACA GCATGGAGTT TATCAACGGC GTCGCCGCCG701 GCGCGCTCAA CCCCTTTATC AGCGCGGGCG AAGCCTTGGG CATAGGCGAC 751ATACTGTACG GAACGCGCTA TGCCATAGAC AAAGCCGCAA TGCGCAACAT 801 CGCCCCCTTGCCCGCCGAGG GCAAATTCGC CGTCATCGGC GGCTTGGGCA 851 GCGTGGCGGG CTTTGAAAAAAATACGCGCG AAGCCGTTGA CCGGTGGATA 901 CAGGAAAACC CCAATGCCGC CGAAACCGTCGAAGCCCTGG TCAACGTCCT 951 GCCGTTTGCC AAAGTCAAAA ACCTGACAAA GGCGGCAAAACCGGGGAAGG 1001 CTGCGGTTAG CGGGGATTTT TCTGCTGCAT ACAATACAAG AACAACTAGA1051 AAAGTTACTA CAGAAACAGA GGGGTTAAAT AGAATCAGAC AGAACCAGAA 1101AAATAGTAAT ATACATGAGA AAAATTATGG AAGAGATAAT CCTAATCATA 1151 TTAATGTTTTATCTGGAAAT TCTATACAAC ATATACTGTA TGGAGATGAA 1201 GCAGGAGGTG GGCATCTTTTTCCTGGCAAA CCTGGTAAGA CAACATTCCC 1251 CCAACATTGG TCAGCCAGTA AAATAACTCATGAAATTAGT GATATCGTTA 1301 CATCCCCAAA AACGCAATGG TATGCACAGA CTGGAACAGGCGGCAAATAT 1351 ATTGCTAAAG GAAGACCAGC TAGGTGGGTA TCATATGAAA CGAGAGATGG1401 AATTCGTATC AGAACAGTTT ATGAACCTGC AACAGGAAAA GTGGTAACTG 1451CATTCCCCGA TAGAACCTCT AATCCCAAAT ATAACCCTGT AAAATAAThis corresponds to the amino acid sequence <SEQ ID 2474; ORF 730.a>:

a730.pep 1 VKPLRRLIKL LAACAVAAAA LIQPALAADL AQDPFITDNA QRQHYEPGGK 51YHLFGDPRGS VSDRTGQINV IQDYTHRMGN LLIQQANING TIGYHTRFSG 101 HGYEEHAPFDNHAADSASEE KGNVDEGFTV YRLNWEGHEH HPADAYDGPK 151 GGNYPKPTGA RDEYTYHVNGTARSIKLNPT DTRSIRQRIS DNYSNLGSNF 201 SDRADEANRK MFEHNAKLDR WGNSMEFINGVAAGALNPFI SAGEALGIGD 251 ILYGTRYAID KAAMRNIAPL PAEGKFAVIG GLGSVAGFEKNTREAVDRWI 301 QENPNAAETV EALVNVLPFA KVKNLTKAAK PGKAAVSGDF SAAYNTRTTR351 KVTTETEGLN RIRQNQKNSN IHEKNYGRDN PNHINVLSGN SIQHILYGDE 401AGGGHLFPGK PGKTTFPQHW SASKITHEIS DIVTSPKTQW YAQTGTGGKY 451 IAKGRPARWVSYETRDGIRI RTVYEPATGK VVTAFPDRTS NPKYNPVK* a730/m730 88.6% identity in376 aa overlap        10        20        30        40        50        60 a730.pepVKPLRRLIKLLAACAVAAAALIQPALAADLAQDPFITDNAQRQHYEPGGKYHLFGDPRGS||||||| :||||||||||||||||||||||||||||||||||||||||||||||||||| m730VKPLRRLTNLLAACAVAAAALIQPALAADLAQDPFITDNAQRQHYEPGGKYHLFGDPRGS        10        20        30        40        50        60        70        80        90       100       110       120 a730.pepVSDRTGQINVIQDYTHRMGNLLIQQANINGTIGYHTRFSGHGYEEHAPFDNHAADSASEE||||||:|||||||||:|||||||||||||||||||||||||:||||||||||||||||| m730VSDRTGKINVIQDYTHQMGNLLIQQANINGTIGYHTRFSGHGHEEHAPFDNHAADSASEE        70        80        90       100       110       120       130       140       150       160       170       180 a730.pepKGNVDEGFTVYRLNWEGHEHHPADAYDGPKGGNYPKPTGARDEYTYHVNGTARSIKLNPT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m730KGNVDEGFTVYRLNWEGHEHHPADAYDGPKGGNYPKPTGARDEYTYHVNGTARSIKLNPT       130       140       150       160       170       180       190       200       210       220       230       240 a730.pepDTRSIRQRISDNYSNLGSNFSDRADEANRKMFEHNAKLDRWGNSMEFINGVAAGALNPFI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m730DTRSIRQRISDNYSNLGSNFSDRADEANRKMFEHNAKLDRWGNSMEFINGVAAGALNPFI       190       200       210       220       230       240       250       260       270       280       290       300 a730.pepSAGEALGIGDILYGTRYAIDKAAMRNIAPLPAEGKFAVIGGLGSVAGFEKNTREAVDRWI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m730SAGEALGIGDILYGTRYAIDKAAMRNIAPLPAEGKFAVIGGLGSVAGFEKNTREAVDRWI       250       260       270       280       290       300       310       320       330       340       350       360 a730.pepQENPNAAETVEALVNVLPFAKVKNLTKAAKPGKAAVSGDFSAAYNTRTTRKVTTETEGLN||||||||||||: ||   ||| :|:||||||||||||||: :|     :|  : ::: m730QENPNAAETVEAVFNVAAAAKVAKLAKAAKPGKAAVSGDFADSY-----KKKLALSDSAR       310       320       330       340       350       370       380       390       400       410       420 a730.pepRIRQNQKNSNIHEKNYGRDNPNHINVLSGNSIQHILYGDEAGGGHLFPGKPGKTTFPQHW ::|| |  :  : :| m730QLYQNAKYREALDIHYEDLIRRKTDGSSKFINGREIDAVTNDALIQAKRTISAIDKPKNF  360       370       380       390       400       410The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2475>:

g731.seq 1 gattttcgag cgttttcatG CGAGAACGGT TTGTCTGTGC GCGTCCGCAA 51TTTGGACGGC GGCAAAATCG CGTTGCGGCT GGACGGCAGG CGTGCCGTCC 101 TCTCTTCCGACGTTGCCGCA TCCGGCGAAC GCTATACCGC CGAACACGGT 151 TTGTTCGGAA ACGGAACCGAGTGGCACCAG AAAGGCGGCG AAGCCTTTTT 201 CGGCTTTACC GATGCCTACG GCAATTCGGTCGAAACTTCC TGCCGCGCCC 251 GTTAAThis corresponds to the amino acid sequence <SEQ ID 2476; ORF 731.ng>:

g731.pep 1 DFRAFSCENG LSVRVRNLDG GKIALRLDGR RAVLSSDVAA SGERYTAEHG 51LFGNGTEWHQ KGGEAFFGFT DAYGNSVETS CRAR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2477>:

m731.seq 1 ATGAATATCA GGTTTTTCGC GCTGACCGTA CCGGTTTTGT CTTTGGCGGC 51CTGTGCCGTG CCGGAGGCGT ATGATGACGG CGGACGCGGG CATATGCCGC 101 CCGTTCAAAACCAAGCCGGC ACGGACGATT TTCGGGCGTT TTCCTGCGAG 151 AACGGTTTGT CTGTGCGCGTCCGCCATTTG GACAGCGGCA AAGTCGCGTT 201 GCGGCTGGAC GGCAGGCGTG CCGTCCTCTCTTCCGACGTT GCCGCATCCG 251 GCGAACGCTA TACCGCCGAA CACGGTTTGT TCGGAAACGCAACCGAGTGG 301 CACCAGAAAG GCGGCGAAGC CTTTTTCGGC TTTACCGATG CCTACGGCAA351 TTCGGTCGAA ACTTCCTGCC GCGCCCGTTA AThis corresponds to the amino acid sequence <SEQ ID 2478; ORF 731>:

m731.pep 1 MNIRFFALTV PVLSLAACAV PEAYDDGGRG HMPPVQNQAG TDDFRAFSCE 51NGLSVRVRHL DSGKVALRLD GRRAVLSSDV AASGERYTAE HGLFGNATEW 101 HQKGGEAFFGFTDAYGNSVE TSCRAR* g731/m731 95.2% identity in 84 aa overlap                                      10        20        30 g731.pep                              DFRAFSCENGLSVRVRNLDGGKIALRLDGR                              ||||||||||||||||:||:||:||||||| m731LSLAACAVPEAYDDGGRGHMPPVQNQAGTDDFRAFSCENGLSVRVRHLDSGKVALRLDGR      20        30        40        50        60        70        40        50        60        70        80 g731.pepRAVLSSDVAASGERYTAEHGLFGNGTEWHQKGGEAFFGFTDAYGNSVETSCRARX||||||||||||||||||||||||:|||||||||||||||||||||||||||||| m731RAVLSSDVAASGERYTAEHGLFGNATEWHQKGGEAFFGFTDAYGNSVETSCRARX      80        90       100       110       120The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2479>:

a731.seq 1 ATGAATATCA GGTTTTTCGC GCTGACCGTA CCGGTTTTGT CTTTGGCGGC 51CTGTGCCGTG CCGGAGGCGT ATGATGACGG CGGACGAGGG CATATGCCGC 101 CCGTTCAAAACCAAGCCGGC ACGGCAGATT TTCGGGCATT TTCCTGCGAG 151 AACGGTTTGT CTGTGCACGTCCGCCGTTTG GACGGCGGCA GAATCGCGTT 201 GCGGTTGGAC GGCAGGCGTG CCGTCCTCTCTTCCGACGTT GCCGCATCCG 251 GCGAACGCTA TACCGCCGAA CACGGTTTGT TCGGAAACGGAACCGAGTGG 301 CATCAGAAAG GCGGCGAAGC CTTTTTCGGC TTTACCGATG CCTACGGCAA351 TTCGGTCGAA ACCTCCTGCC GCGAACGCTA AThis corresponds to the amino acid sequence <SEQ ID 2480; ORF 731.a>:

a731.pep 1 MNIRFFALTV PVLSLAACAV PEAYDDGGRG HMPPVQNQAG TADFRAFSCE 51NGLSVHVRRL DGGRIALRLD GRRAVLSSDV AASGERYTAE HGLFGNGTEW 101 HQKGGEAFFGFTDAYGNSVE TSCRAR* a731/m731 94.4% identity in 126 aa overlap        10        20        30        40        50        60 a731.pepMNIRFFALTVPVLSLAACAVPEAYDDGGRGHMPPVQNQAGTADFRAFSCENGLSVHVRRL||||||||||||||||||||||||||||||||||||||||| |||||||||||||:||:| m731MNIRFFALTVPVLSLAACAVPEAYDDGGRGHMPPVQNQAGTDDFRAFSCENGLSVRVRHL        10        20        30        40        50        60        70        80        90       100       110       120 a731.pepDGGRIALRLDGRRAVLSSDVAASGERYTAEHGLFGNGTEWHQKGGEAFFGFTDAYGNSVE|:|::|||||||||||||||||||||||||||||||:||||||||||||||||||||||| m731DSGKVALRLDGRRAVLSSDVAASGERYTAEHGLFGNATEWHQKGGEAFFGFTDAYGNSVE        70        80        90       100       110       120 a731.pepTSCRARX ||||||| m731 TSCRARXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2481>:

g732.seq 1 ATGTCGAAAC CTGTTTTTAA GAAAATCGCA CTTTATACTT TGGGTGCAAT 51CAGCGGCGTG GCCGTAAGTC TGGCGGTGCA GGGTTTTGCC GCCGagaagg 101 ACGGgcgGGATAACGAagtC CTGCCGGTGC AATCCATCCG TACGATGGCG 151 GAGGTTTACG GTCAGATTAAGGCAAACTAC TATCATGACA AACCCGATGC 201 CGATTTGTTT GAAGGTGCGA TGAAGGGTATGGTGGCCGGT TTGGATCCGC 251 ATTCCGAATA TATGGATAAA AAAGGTTATG CCGAGATAAAGGAGTCCACC 301 AGCGGCGAAT TTGGCGGCTT GGGGATGGAA ATCGGGCAGG AAGACGGTTT351 TGTCAAAGTG GTTTCGCCGA TTGAGGACAC GCCTGCCGAA CGGGCGGAGG 401TGAAAAGCGG CGATTTCATT GTGAAAATCG ATAATGTTTC GACGCGCGGT 451 ATGACGGTCAGCGAAGCGGT GAAAAAAATG CGGGGCAAGC CGGGTACGAA 501 GATTACTTTG ACGTTGTCGCGCAAAAATGC CGACAAGCCG ATAGTCGTCA 551 ACCTGACCCG TGCCATTATT AAAGTGAAAAGCGTCCGCCA TCACCTGATC 601 GAACCCGATT ACGGCTATAT CCGCGTGTCG CAGTTCCAAGAGCGGACGGT 651 CGAAAGCGTC AATACCGCCG CAAAAGAGCT GGTAAAGGAA AATAAAGGAA701 AACCGCTCAA GGGGCTGGTG TTGGATTTGC GCGACGACCC CGGCGGGCTT 751TTGACCGGCG CGGTCGGCGT GTCGGCGGCG TTTCTGCCGT CTGAAGCGGT 801 CGTCGTCAGCACCAAGGGAC GCGACGGCAA AGACGGCATG GTACTGAAAG 851 CCGTTCCCGA GGATTATGTGTACGGTATGG GCGGCGACCC TTTGGCGGGT 901 ATTCCTGCCG AGTTGAAAAC GATTCCGATGACGgtaTTGG TcaaTTCCGG 951 TTCggcttCC GCGTCGGAGA TTGtcgCCGG CGCATTGCAGGACCACAAAC 1001 GCGCGGTCAT CGTCGGTACG CAGAGCTTCG GTAAAGGTTC GGTTCAGACT1051 TTGATTCCTT TGTCCAACGG CAGCGCGGTC AAGTTGACGA CCGCCCTGTA 1101TTACACGCCG AACGACCGTT CCATTCAGGC ACAGGGGATT GTTCCCGATG 1151 TCgaaGTAAAAGATAAGGAA CGTACTTTTG AAAGCCGCGA GGCGGACCTG 1201 GTCGGACACA TCGGCAATCCCTTgggcGGC GAGGATGTGA ACAGTGAAAC 1251 CCttgcCGTA CCGCTTGAAA AAGATGCGGATAAGCCCGCT GCAAAAGAAA 1301 AAGGTAAAAA GAAAAAGGAC GAGGATTTGT CTTCAAGGCGGATTCCGAAC 1351 CCTGCGAAAG ACGATCAGTT GCGTAAGGCT TTGGATTTGG TCAAGTCGCC1401 CGAGCAGTGG CAGAAGTCTT TGGGGCTGGC GGCGAAAAAA CCGGTTTCAA 1451ATAAAGATAA AAAAGATAAG AAGTAGThis corresponds to the amino acid sequence <SEQ ID 2482; ORF 732>:

g732.pep 1 MSKPVFKKIA LYTLGAISGV AVSLAVQGFA AEKDGRDNEV LPVQSIRTMA 51EVYGQIKANY YHDKPDADLF EGAMKGMVAG LDPHSEYMDK KGYAEIKEST 101 SGEFGGLGMEIGQEDGFVKV VSPIEDTPAE RAEVKSGDFI VKIDNVSTRG 151 MTVSEAVKKM RGKPGTKITLTLSRKNADKP IVVNLTRAII KVKSVRHHLI 201 EPDYGYIRVS QFQERTVESV NTAAKELVKENKGKPLKGLV LDLRDDPGGL 251 LTGAVGVSAA FLPSEAVVVS TKGRDGKDGM VLKAVPEDYVYGMGGDPLAG 301 IPAELKTIPM TVLVNSGSAS ASEIVAGALQ DHKRAVIVGT QSFGKGSVQT351 LIPLSNGSAV KLTTALYYTP NDRSIQAQGI VPDVEVKDKE RTFESREADL 401VGHIGNPLGG EDVNSETLAV PLEKDADKPA AKEKGKKKKD EDLSSRRIPN 451 PAKDDQLRKALDLVKSPEQW QKSLGLAAKK PVSNKDKKDK K*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2483>:

m732.seq 1 ATGTCGAAAC CTGTTTTTAA GAAAATCGCA CTTTATACTT TGGGTGCAAT 51CAGCGGCGTG GCCGTCAGTC TGGCGGTGCA GGGTTTTGCC GCCGAGAAGG 101 ACAGGCGGGATAACGAAGTC CTGCCGGTGC AATCCATCCG CACAATGGCG 151 GAGGTTTACG GTCAAATCAAGGCAAACTAC TATCAGGACA AACCCGATGC 201 CGATTTGTTT GAAGGTGCGA TGAAGGGTATGGTGGCCGGT TTGGATCCGC 251 ATTCCGAATA TATGGATAAA AAAGGTTATG CCGAGATAAAGGAGTCCACC 301 AGCGGCGAAT TTGGCGGCTT GGGGATGGAA ATCGGGCAGG AAGACGGATT351 TGTCAAAGTG GTTTCGCCGA TTGAGGACAC GCCTGCGGAA CGGGCGGGGG 401TGAAAAGCGG CGATTTCATT GTGAAAATCG ATAATGTTTC GACACGCGGC 451 ATGACGGTCAGCGAAGCGGT GAAGAAAATG CGGGGCAAGC CGGGTACGAA 501 GATTACTTTG ACGCTGTCGCGCAAAAATGC CGACAAGCCG ATAGTCGTCA 551 ACCTGACCCG TGCCATTATT AAAGTGAAAAGCGTCCGCCA TCACCTGATC 601 GAACCCGATT ACGGCTATAT CCGCGTGTCG CAGTTCCAAGAGCGGACGGT 651 CGAAAGCGTC AATACCGCCG CAAAAGAGCT GGTAAAGGAA AATAAAGGAA701 AACCGCTCAA GGGGCTGGTG TTGGATTTGC GCGACGACCC CGGCGGGCTT 751TTGACTGGCG CGGTCGGCGT GTCGGCGGCA TTTCTGCCGT CTGAAGCAGT 801 CGTCGTCAGCACCAAGGGAC GCGACGGCAA AGACCGCATG GTACTGAAAG 851 CCATTCCTGA AGATTATGTGTACGGGATGG GCGGCGATTC GTTGGCGGGC 901 ATTCCTGCCG AGTTGAAAAC CATACCGATGACGGTATTGG TCAATTCCGG 951 TTCGGCTTCC GCGTCGGAGA TTGTCGCAGG TGCATTGCAGGATCATAAAC 1001 GCGCGGTCAT CGTCGGTACG CAGAGCTTCG GCAAAGGTTC GGTTCAGACT1051 TTGATTCCTT TGTCCAACGG CAGCGCGGTC AAGCTGACAA CGGCACTGTA 1101TTATACGCCG AACGACCGTT CTATTCAGGC GCAGGGGATT GTTCCCGATG 1151 TCGAAGTAAAAGATAAGGAA CGCATTTTTG AAAGCCGCGA GGCGGATTTG 1201 GTCGGACACA TCGGCAATCCCTTGGGCGGC GAGGATGTGA ACGGTGAAAC 1251 CCTTGCCGTG CCGCTTGAAA AAGATGCGGATAAGCCCGCT GTAAAAGAAA 1301 AAGGTAAAAA GAAAAAGGAC GAGGATTTGT CTTCAAGGCGGATTCCCAAC 1351 CCTGCCAAAG ACGACCAGTT GCGGAAAGCT TTGGATTTAG TCAAGTCGCC1401 CGAGCAGTGG CAGAAGTCTT TGGGGCTGGC GGCGAAAAAG CCGGTTTCAA 1451ATAAAGATAA GAAAGATAAA AAAGATAAGA AGTAGThis corresponds to the amino acid sequence <SEQ ID 2484; ORF 732>:

m732.pep 1 MSKPVFKKIA LYTLGAISGV AVSLAVQGFA AEKDRRDNEV LPVQSIRTMA 51EVYGQIKANY YQDKPDADLF EGAMKGMVAG LDPHSEYMDK KGYAEIKEST 101 SGEFGGLGMEIGQEDGFVKV VSPIEDTPAE RAGVKSGDFI VKIDNVSTRG 151 MTVSEAVKKM RGKPGTKITLTLSRKNADKP IVVNLTRAII KVKSVRHHLI 201 EPDYGYIRVS QFQERTVESV NTAAKELVKENKGKPLKGLV LDLRDDPGGL 251 LTGAVGVSAA FLPSEAVVVS TKGRDGKDRM VLKAIPEDYVYGMGGDSLAG 301 IPAELKTIPM TVLVNSGSAS ASEIVAGALQ DHKRAVIVGT QSFGKGSVQT351 LIPLSNGSAV KLTTALYYTP NDRSIQAQGI VPDVEVKDKE RIFESREADL 401VGHIGNPLGG EDVNGETLAV PLEKDADKPA VKEKGKKKKD EDLSSRRIPN 451 PAKDDQLRKALDLVKSPEQW QKSLGLAAKK PVSNKDKKDK KDKK*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 732 shows 98.2% identity over a 491 aa overlap with a predicted ORF(ORF732.a) from N. gonorrhoeae:

m732/g732 98.2% identity in 491 aa overlap        10        20        30        40        50        60 m732.pepMSKPVFKKIALYTLGAISGVAVSLAVQGFAAEKDRRDNEVLPVQSIRTMAEVYGQIKANY|||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||| g732MSKPVFKKIALYTLGAISGVAVSLAVQGFAAEKDGRDNEVLPVQSIRTMAEVYGQIKANY        10        20        30        40        50        60        70        80        90       100       110       120 m732.pepYQDKPDADLFEGAMKGMVAGLDPHSEYMDKKGYAEIKESTSGEFGGLGMEIGQEDGFVKV|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g732YHDKPDADLFEGAMKGMVAGLDPHSEYMDKKGYAEIKESTSGEFGGLGMEIGQEDGFVKV        70        80        90       100       110       120       130       140       150       160       170       180 m732.pepVSPIEDTPAERAGVKSGDFIVKIDNVSTRGMTVSEAVKKMRGKPGTKITLTLSRKNADKP|||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||| g732VSPIEDTPAERAEVKSGDFIVKIDNVSTRGMTVSEAVKKMRGKPGTKITLTLSRKNADKP       130       140       150       160       170       180       190       200       210       220       230       240 m732.pepIVVNLTRAIIKVKSVRHHLIEPDYGYIRVSQFQERTVESVNTAAKELVKENKGKPLKGLV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g732IVVNLTRAIIKVKSVRHHLIEPDYGYIRVSQFQERTVESVNTAAKELVKENKGKPLKGLV       190       200       210       220       230       240       250       260       270       280       290       300 m732.pepLDLRDDPGGLLTGAVGVSAAFLPSEAVVVSTKGRDGKDRMVLKAIPEDYVYGMGGDSLAG|||||||||||||||||||||||||||||||||||||| |||||:||||||||||| ||| g732LDLRDDPGGLLTGAVGVSAAFLPSEAVVVSTKGRDGKDGMVLKAVPEDYVYGMGGDPLAG       250       260       270       280       290       300       310       320       330       340       350       360 m732.pepIPAELKTIPMTVLVNSGSASASEIVAGALQDHKRAVIVGTQSFGKGSVQTLIPLSNGSAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g732IPAELKTIPMTVLVNSGSASASEIVAGALQDHKRAVIVGTQSFGKGSVQTLIPLSNGSAV       310       320       330       340       350       360       370       380       390       400       410       420 m732.pepKLTTALYYTPNDRSIQAQGIVPDVEVKDKERIFESREADLVGHIGNPLGGEDVNGETLAV||||||||||||||||||||||||||||||| ||||||||||||||||||||||:||||| g732KLTTALYYTPNDRSIQAQGIVPDVEVKDKERTFESREADLVGHIGNPLGGEDVNSETLAV       370       380       390       400       410       420       430       440       450       460       470       480 m732.pepPLEKDADKPAVKEKGKKKKDEDLSSRRIPNPAKDDQLRKALDLVKSPEQWQKSLGLAAKK||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||| g732PLEKDADKPAAKEKGKKKKDEDLSSRRIPNPAKDDQLRKALDLVKSPEQWQKSLGLAAKK       430       440       450       460       470       480        490m732.pep PVSNKDKKDKKDKKX ||||||||||| g732 PVSNKDKKDKKX        490The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2485>:

a732.seq 1 ATGTCGAAAC CTGTTTTTAA GAAAATCGCA CTTTATACTT TGGGTGCAAT 51CAGCGGCGTG GCCGTCAGTC TGGCGGTGCA GGGTTTTGCC GCCGAGAAGG 101 ACAGGCGGGATAACGAAGTC CTGCCGGTGC AATCCATCCG CACAATGGCG 151 GAGGTTTACG GTCAAATCAAGGCAAACTAC TATCAGGACA AACCCGATGC 201 CGATTTGTTT GAAGGTGCGA TGAAGGGTATGGTGGCCGGT TTGGATCCGC 251 ATTCCGAATA TATGGATAAA AAAGGTTATG CCGAGATAAAGGAGTCCACC 301 AGCGGCGAAT TTGGCGGCTT GGGGATGGAA ATCGGGCAGG AAGACGGATT351 TGTCAAAGTG GTTTCGCCGA TTGAGGACAC GCCTGCGGAA CGGGCGGGGG 401TGAAAAGCGG CGATTTCATT GTGAAAATCG ATAATGTTTC GACACGCGGC 451 ATGACGGTCAGCGAAGCGGT GAAGAAAATG CGGGGCAAGC CGGGTACGAA 501 GATTACTTTG ACGCTGTCGCGCAAAAATGC CGACAAGCCG ATAGTCGTCA 551 ACCTGACCCG TGCCATTATT AAAGTGAAAAGCGTCCGCCA TCACCTGATC 601 GAACCCGATT ACGGCTATAT CCGCGTGTCG CAGTTCCAAGAGCGGACGGT 651 CGAAAGCGTC AATACCGCCG CAAAAGAGCT GGTAAAGGAA AATAAAGGAA701 AACCGCTCAA GGGGCTGGTG TTGGATTTGC GCGACGACCC CGGCGGGCTT 751TTGACTGGCG CGGTCGGCGT GTCGGCGGCA TTTCTGCCGT CTGAAGCAGT 801 CGTCGTCAGCACCAAGGGAC GCGACGGCAA AGACCGCATG GTACTGAAAG 851 CCGTTCCTGA AGATTATGTGTACGGGATGG GCGGCGATTC GTTGGCGGGC 901 ATTCCTGCCG AGTTGAAAAC CATACCGATGACGGTATTGG TCAATTCCGG 951 TTCGGCTTCC GCGTCGGAGA TTGTCGCAGG TGCATTGCAGGATCATAAAC 1001 GCGCGGTCAT CGTCGGTACG CAGAGCTTCG GCAAAGGTTC GGTTCAGACT1051 TTGATTCCTT TGTCCAACGG CAGCGCGGTC AAGCTGACAA CGGCACTGTA 1101TTATACGCCG AACGACCGTT CTATTCAGGC GCAGGGGATT GTTCCCGATG 1151 TCGAAGTAAAAGATAAGGAA CGCATTTTTG AAAGCCGCGA GGCGGATTTG 1201 GTCGGACACA TCGGCAATCCTTTGGGCGGC GAGGATGTGA ACAGTGAAAC 1251 CCTTGCCGTG CCGCTTGAAA AAGATGCGGATAAGCCCGCT GTAAAAGAAA 1301 AAGGTAAAAA GAAAAAGGAC GAGGATTTGT CTTCAAGGCGGATTCCCAAC 1351 CCTGCCAAAG ACGACCAGTT GCGGAAAGCT TTGGATTTAG TCAAGTCGCC1401 CGAGCAGTGG CAGAAGTCTT TGGGGCTGGC GGCGAAAAAG CCGGTTTCAA 1451ATAAAGATAA GAAAGATAAA AAAGATAAGA AGTAGThis corresponds to the amino acid sequence <SEQ ID 2486; ORF 732.a>:

a732.pep 1 MSKPVFKKIA LYTLGAISGV AVSLAVQGFA AEKDRRDNEV LPVQSIRTMA 51EVYGQIKANY YQDKPDADLF EGAMKGMVAG LDPHSEYMDK KGYAEIKEST 101 SGEFGGLGMEIGQEDGFVKV VSPIEDTPAE RAGVKSGDFI VKIDNVSTRG 151 MTVSEAVKKM RGKPGTKITLTLSRKNADKP IVVNLTRAII KVKSVRHHLI 201 EPDYGYIRVS QFQERTVESV NTAAKELVKENKGKPLKGLV LDLRDDPGGL 251 LTGAVGVSAA FLPSEAVVVS TKGRDGKDRM VLKAVPEDYVYGMGGDSLAG 301 IPAELKTIPM TVLVNSGSAS ASEIVAGALQ DHKRAVIVGT QSFGKGSVQT351 LIPLSNGSAV KLTTALYYTP NDRSIQAQGI VPDVEVKDKE RIFESREADL 401VGHIGNPLGG EDVNSETLAV PLEKDADKPA VKEKGKKKKD EDLSSRRIPN 451 PAKDDQLRKALDLVKSPEQW QKSLGLAAKK PVSNKDKKDK KDKK* a732/m732 99.6% identity in 494aa overlap         10        20        30        40        50        60a732.pep MSKPVFKKIALYTLGAISGVAVSLAVQGFAAEKDRRDNEVLPVQSIRTMAEVYGQIKANY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m732MSKPVFKKIALYTLGAISGVAVSLAVQGFAAEKDRRDNEVLPVQSIRTMAEVYGQIKANY        10        20        30        40        50        60        70        80        90       100       110       120 a732.pepYQDKPDADLFEGAMKGMVAGLDPHSEYMDKKGYAEIKESTSGEFGGLGMEIGQEDGFVKV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m732YQDKPDADLFEGAMKGMVAGLDPHSEYMDKKGYAEIKESTSGEFGGLGMEIGQEDGFVKV        70        80        90       100       110       120       130       140       150       160       170       180 a732.pepVSPIEDTPAERAGVKSGDFIVKIDNVSTRGMTVSEAVKKMRGKPGTKITLTLSRKNADKP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m732VSPIEDTPAERAGVKSGDFIVKIDNVSTRGMTVSEAVKKMRGKPGTKITLTLSRKNADKP       130       140       150       160       170       180       190       200       210       220       230       240 a732.pepIVVNLTRAIIKVKSVRHHLIEPDYGYIRVSQFQERTVESVNTAAKELVKENKGKPLKGLV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m732IVVNLTRAIIKVKSVRHHLIEPDYGYIRVSQFQERTVESVNTAAKELVKENKGKPLKGLV       190       200       210       220       230       240       250       260       270       280       290       300 a732.pepLDLRDDPGGLLTGAVGVSAAFLPSEAVVVSTKGRDGKDRMVLKAVPEDYVYGMGGDSLAG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m732LDLRDDPGGLLTGAVGVSAAFLPSEAVVVSTKGRDGKDRMVLKAIPEDYVYGMGGDSLAG       250       260       270       280       290       300       310       320       330       340       350       360 a732.pepIPAELKTIPMTVLVNSGSASASEIVAGALQDHKRAVIVGTQSFGKGSVQTLIPLSNGSAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m732IPAELKTIPMTVLVNSGSASASEIVAGALQDHKRAVIVGTQSFGKGSVQTLIPLSNGSAV       310       320       330       340       350       360       370       380       390       400       410       420 a732.pepKLTTALYYTPNDRSIQAQGIVPDVEVKDKERIFESREADLVGHIGNPLGGEDVNSETLAV||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| m732KLTTALYYTPNDRSIQAQGIVPDVEVKDKERIFESREADLVGHIGNPLGGEDVNGETLAV       370       380       390       400       410       420       430       440       450       460       470       480 a732.pepPLEKDADKPAVKEKGKKKKDEDLSSRRIPNPAKDDQLRKALDLVKSPEQWQKSLGLAAKK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m732PLEKDADKPAVKEKGKKKKDEDLSSRRIPNPAKDDQLRKALDLVKSPEQWQKSLGLAAKK       430       440       450       460       470       480        490a732.pep PVSNKDKKDKKDKKX ||||||||||||||| m732 PVSNKDKKDKKDKKX        490The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2487>:

g733.seq 1 ATGATGAATC CGAAAACCTT GGGCCGTTTG TCGCTGTGTG CGGCGGTCTT 51GGCTCTGACC GCCTGCGCCG GCGGCGGGCA TAAAAACCTG TATTATTACG 101 GCGGTTATCCCGATACCGTC TATGAAGGTT TGAAAAACGa cgACACTTCG 151 TTGGGCAAGC AGACCGAAAAGATGGAAAAA TACTTTGCGG AAGCCGCCAA 201 CAAAAAAATG AATGCCGCCC CGGGTGCGCACGCCCATTTG GGACTGCTGC 251 TTTCCCGTTC GGGAGACAAA GAGGGCGCGT TCCGCCAATTTGAAGAAGAG 301 AAAAGGCTGT TTCCCGAATC GGGCGTATTT ATGGACTTCC TGATGAAAAC351 CGGtaaAGGA GGCAAGCGAT GAThis corresponds to the amino acid sequence <SEQ ID 2488; ORF 733>:

g733.pep 1 MMNPKTLGRL SLCAAVLALT ACAGGGHKNL YYYGGYPDTV YEGLKNDDTS 51LGKQTEKMEK YFAEAANKKM NAAPGAHAHL GLLLSRSGDK EGAFRQFEEE 101 KRLFPESGVFMDFLMKTGKG GKR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2489>:

m733.seq 1 ATGATGAATC CGAAAACCTT GAGCCGTTTG TCGCTGTGTG CGGCGGTCTT 51GGCTCTGACC GCCTGCGGCG GCAACGGGCA AAAATCCCTG TATTATTACG 101 GCGGCTATCCCGATACCGTC TATGAAGGTT TGAAAAACGA CGACACTTCG 151 TTGGGCAAGC AGACCGAAAAGATGGAAAAA TACTTTGTGG AAGCCGGCAA 201 CAAAAAAATG AATGCCGCCC CGGGTGCGCACGCCCATCTG GGACTGCTGC 251 TTTCCCGTTC GGGAGACAAA GAGGGCGCGT TCCGCCAGTTTGAAGAAGAG 301 AAAAGGCTGT TTCCCGAATC GGGCGTATTT ATGGACTTCC TGATGAAAAC351 CGGTAAAGGA GGCAAGCGAT GAThis corresponds to the amino acid sequence <SEQ ID 2490; ORF 733>:

m733.pep 1 MMNPKTLSRL SLCAAVLALT ACGGNGQKSL YYYGGYPDTV YEGLKNDDTS 51LGKQTEKMEK YFVEAGNKKM NAAPGAHAHL GLLLSRSGDK EGAFRQFEEE 101 KRLFPESGVFMDFLMKTGKG GKR*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 733 shows 94.3% identity over a 123 aa overlap with a predicted ORF(ORF733.a) from N. gonorrhoeae:

m733/g733         10        20        30        40        50        60m733.pep MMNPKTLSRLSLCAAVLALTACGGNGQKSLYYYGGYPDTVYEGLKNDDTSLGKQTEKMEK|||||||:||||||||||||||:|:|:|:||||||||||||||||||||||||||||||| g733MMNPKTLGRLSLCAAVLALTACAGGGHKNLYYYGGYPDTVYEGLKNDDTSLGKQTEKMEK        10        20        30        40        50        60        70        80        90       100       110       120 m733.pepYFVEAGNKKMNAAPGAHAHLGLLLSRSGDKEGAFRQFEEEKRLFPESGVFMDFLMKTGKG||:||:|||||||||||||||||||||||||||||||||||||||||||||||||||||| g733YFAEAANKKMNAAPGAHAHLGLLLSRSGDKEGAFRQFEEEKRLFPESGVFMDFLMKTGKG        70        80        90       100       110       120 m733.pepGKRX |||| g733 GKRXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2491>:

a733.seq 1 ATGATGAATC CGAAAACCTT GAGCCGTTTG TCGCTGTGTG CGGCGGTCTT 51GGCTCTGACC GCCTGCGGCG GCAACGGGCA AAAATCCCTG TATTATTACG 101 GCGGCTATCCCGATACCGTC TATGAAGGTT TGAAAAACGA CGACACTTCG 151 TTGGGCAAGC AGACCGAAAAGATGGAAAAA TACTTTGTGG AAGCCGGCAA 201 CAAAAAAATG AATGCCGCCC CGGGTGCGCACGCCCATCTG GGACTGCTGC 251 TTTCCCGTTC GGGAGACAAA GAGGGCGCGT TCCGCCAGTTTGAAGAAGAG 301 AAAAGGCTGT TTCCCGAATC GGGCGTATTT ATGGACTTCC TGATGAAAAC351 CGGTAAAGGA GGCAAGCGAT GAThis corresponds to the amino acid sequence <SEQ ID 2492; ORF 733.a>:

a733.pep 1 MMNPKTLSRL SLCAAVLALT ACGGNGQKSL YYYGGYPDTV YEGLKNDDTS 51LGKQTEKMEK YFVEAGNKKM NAAPGAHAHL GLLLSRSGDK EGAFRQFEEE 101 KRLFPESGVFMDFLMKTGKG GKR* a733/m733 100.0% identity in 123 aa overlap        10        20        30        40        50        60 a733.pepMMNPKTLSRLSLCAAVLALTACGGNGQKSLYYYGGYPDTVYEGLKNDDTSLGKQTEKMEK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m733MMNPKTLSRLSLCAAVLALTACGGNGQKSLYYYGGYPDTVYEGLKNDDTSLGKQTEKMEK        10        20        30        40        50        60        70        80        90       100       110       120 a733.pepYFVEAGNKKMNAAPGAHAHLGLLLSRSGDKEGAFRQFEEEKRLFPESGVFMDFLMKTGKG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m733YFVEAGNKKMNAAPGAHAHLGLLLSRSGDKEGAFRQFEEEKRLFPESGVFMDFLMKTGKG        70        80        90       100       110       120 a733.pepGKRX |||| m733 GKRXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2493>:

g734.seq 1 ATGATGAAAA AGATACTGGC AGTATCGGCA CTATGCCTGA TGACTGCGGC 51GGCACAGGCT GCCGATACTT ACGGCTATCT CGCCGTTTGG CAGAATCCGC 101 AGGATGCAAACGATGTTTTG CAGGTTAAAA CCACAAAAGA AGATTCGGCG 151 AAAAGCGAAG CGTTTGCCGAGTTGGAAGCC TTTTGCAAAG GTCAGGACAC 201 GCTTGCGGGC ATTGCCGAAG ACGAGCCGACCGGATGCCGG TCGGTCGTGT 251 CGCTGAACAA TACCTGTGTC TCGCTGGCAT ACCCGAAAGCCTTGGGCGCG 301 ATGCGCGTTG AAAACGCCGT CGTGATTACT TCTCCGCGTT TTACGAGCGT351 TCATCAGGTC GCACTCAACC AGTGCATAAA AAAATACGGC GCACAGGGAC 401AATGCGGCTT GGAAACAGTG TATTGCACGT CATCTTCTTA TTACGGCGGG 451 GCTGTTCGCTCCTTAATCCA ACACCTGAAA TAAThis corresponds to the amino acid sequence <SEQ ID 2494; ORF 734.ng>:

g734.pep 1 MMKKILAVSA LCLMTAAAQA ADTYGYLAVW QNPQDANDVL QVKTTKEDSA 51KSEAFAELEA FCKGQDTLAG IAEDEPTGCR SVVSLNNTCV SLAYPKALGA 101 MRVENAVVITSPRFTSVHQV ALNQCIKKYG AQGQCGLETV YCTSSSYYGG 151 AVRSLIQHLK *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2495>:

m734.seq (partial) 1 TCGGGCATTG CTGAAGACGA GCCGACCGGA TGCCGGTCGGTCGTGTCGCT 51 GAACAATACC TGTGTCGCGC TGGCATACCC GAAAGCCTTG GGCGCGCTGC 101GTGTCGACAA CGCCGTCGTG ATTACTTCTC CGCGTTTTAC GAGCGTTCAT 151 CAGGTCGCACTCAACCAGTG CATCAAAAAA TACGGCGTAC AGGGACAATG 201 CGGCTTGGAA ACAGTGTATTGCACATCTTC TTCTTATTAC GGCGGAACTG 251 TGCGCTCTTT GATTCAAAAT CTCAAATAAThis corresponds to the amino acid sequence <SEQ ID 2496; ORF 734>:

m734.pep (partial) 1 SGIAEDEPTG CRSVVSLNNT CVALAYPKAL GALRVDNAVVITSPRFTSVH 51 QVALNQCIKK YGVQGQCGLE TVYCTSSSYY GGTVRSLIQN LK* m734/g73492.4% identity in 92 aa overlap                                       10        20        30 m734.pep                               SGIAEDEPTGCRSVVSLNNTCVALAYPKAL                               :|||||||||||||||||||||:||||||| g734 VLQVKTTKEDSAKSEAFAELEAFCKGQDTLAGIAEDEPTGCRSVVSLNNTCVSLAYPKAL 40        50        60        70        80        90         40        50        60        70        80        90 m734.pep GALRVDNAVVITSPRFTSVHQVALNQCIKKYGVQGQCGLETVYCTSSSYYGGTVRSLIQN ||:||:||||||||||||||||||||||||||:|||||||||||||||||||:||||||: g734 GAMRVENAVVITSPRFTSVHQVALNQCIKKYGAQGQCGLETVYCTSSSYYGGAVRSLIQH100       110       120       130       140       150 m734.pep  LKX  |||g734  LKX 160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2497>:

a734.seq 1 ATGATGAAAA AGATACTGGC CGTATCGGCA CTATGCCTGA TGACTGCGGC 51GGCACGGGCT GCCGATACTT ACGGCTATCT CGCCGTTTGG CAGAATCCGC 101 AGAATGCAAACGATGTTTTG CAGGTTAAAA CCACAAAAGA AGATTCGACG 151 AAAAGCGAAG CGTTTGCCGAGTTGGAAGCT TTCTGCAAAG GTCAGGACAC 201 GCTTGCGGGC ATTGCCGAAG ACGAGCCGACCGGATGCCGG TCGGTCGTGT 251 CGCTGAACAA TACCTGTGTC GCGCTGGCAT ACCCGAAAGCCTTGGGCGCG 301 ATGCGCGTTG AAAACGCCGT TGTGATTACT TCTCCGCGTT TTACGAGCGT351 TTATCAGGTC GCACTCAACC AGTGCATCAA AAAATACGGC GCACAGGGAC 401AATGCGGCTT GGAAACAGTG TATTGCACGT CTTCTTCTTA TTACGGGGGA 451 ACTGTGCGCTCTTTGATTCA AAATCTCAAA TAAThis corresponds to the amino acid sequence <SEQ ID 2498; ORF 734.a>:

a734.pep 1 MMKKILAVSA LCLMTAAARA ADTYGYLAVW QNPQNANDVL QVKTTKEDST 51KSEAFAELEA FCKGQDTLAG IAEDEPTGCR SVVSLNNTCV ALAYPKALGA 101 MRVENAVVITSPRFTSVYQV ALNQCIKKYG AQGQCGLETV YCTSSSYYGG 151 TVRSLIQNLK * a734/g73495.6% identity in 160 aa overlap        10        20        30        40        50        60 a734.pepMMKKILAVSALCLMTAAARAADTYGYLAVWQNPQNANDVLQVKTTKEDSTKSEAFAELEA||||||||||||||||||:|||||||||||||||:||||||||||||||:|||||||||| g734MMKKILAVSALCLMTAAAQAADTYGYLAVWQNPQDANDVLQVKTTKEDSAKSEAFAELEA        10        20        30        40        50        60        70        80        90       100       110       120 a734.pepFCKGQDTLAGIAEDEPTGCRSVVSLNNTCVALAYPKALGAMRVENAVVITSPRFTSVYQV||||||||||||||||||||||||||||||:||||||||||||||||||||||||||:|| g734FCKGQDTLAGIAEDEPTGCRSVVSLNNTCVSLAYPKALGAMRVENAVVITSPRFTSVHQV        70        80        90       100       110       120       130       140       150       160 a734.pepALNQCIKKYGAQGQCGLETVYCTSSSYYGGTVRSLIQNLKX||||||||||||||||||||||||||||||:||||||:||| g734ALNQCIKKYGAQGQCGLETVYCTSSSYYGGAVRSLIQHLKX       130       140       150       160

g735.seq not found yet

g735.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2499>:

m735.seq 1 ATGAATCTCG TGAAACTGCT GGCGAATAAC TGGCAACCGA TTGCCATTAT 51CGCGCTTGTC GGCACGGGCT TGGCTGTGTC GCACCATCAA GGCTACAAGT 101 CGGCATTTGCGAAGCAGCAG GCGGTCATCG ACAAGATGGA GCGCGACAAG 151 GCGCAAGCCC TGCTGTTGTCGGCTCAAAAC TATGCGCGCG AACTGGAACT 201 GGCACGCGCG GAAGCTAAAA AATATGAAGTCAAGGCGCAC GCTGTCGGCA 251 TGGCTTTGGC GAAAAAACAG GCGGAAGTCA GCCGTCTGAAAACGGAAAAT 301 AAAAAGGAAA TCGAAAATGT CCTTACTCAA GACCGTAAAA ATGCAAGCGG351 CGGTTGCATT GACGGCTTTG GCTCTCACGG CCTGCAGCTC TACAACCGCG 401CCCTCGGCTA CGGAAATTAAThis corresponds to the amino acid sequence <SEQ ID 2500; ORF 735>:

m735.pep 1 MNLVKLLANN WQPIAIIALV GTGLAVSHHQ GYKSAFAKQQ AVIDKMERDK 51AQALLLSAQN YARELELARA EAKKYEVKAH AVGMALAKKQ AEVSRLKTEN 101 KKEIENVLTQDRKNASGGCI DGFGSHGLQL YNRALGYGN*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2501>:

a735.seq 1 ATGAATCTCG TGAAACTGCT GGCGAATAAC TGGCAACCGA TTGCCATCAT 51CGCGCTTGTC GGCACGGGTT TGGCGGTGTC GCACCATCAA GGCTACAAGT 101 CGGCTTTTGCGAAGCAGCAG GCGGTCATTG AGAAAATGAA GCGCGACAAG 151 GCGCAAGCCC TGCTGTTGTCGGCTCAAAAC TACGCCCGCG AACTGGAACA 201 GGCGCGTGCG GAAGCTAAAA AATATGAAGTCAAGGCGCAC GCCGTCGGCA 251 TGGCTTTGGC GAAAAAACAG GCGGAAGTCA GCCGTCTGAAAACGGAAAAT 301 AAAAAGGAAA TCGAAAATGT CCTTACTCAA GACCGTAAAA ATGCAGGCGG351 CGGTTGTATT GACGGCTTTG GCCATCACGG CTTGCAGCTC TACAAGCGCG 401CCCTCGGCTA CGGAAATTAAThis corresponds to the amino acid sequence <SEQ ID 2502; ORF 735.a>:

a735.pep 1 MNLVKLLANN WQPIAIIALV GTGLAVSHHQ GYKSAFAKQQ AVIEKMKRDK 51AQALLLSAQN YARELEQARA EAKKYEVKAH AVGMALAKKQ AEVSRLKTEN 101 KKEIENVLTQDRKNAGGGCI DGFGHHGLQL YKRALGYGN* a735/m735 95.7% identity in 139 aaoverlap         10        20        30        40        50        60a735.pep MNLVKLLANNWQPIAIIALVGTGLAVSHHQGYKSAFAKQQAVIEKMKRDKAQALLLSAQN|||||||||||||||||||||||||||||||||||||||||||:||:||||||||||||| m735MNLVKLLANNWQPIAIIALVGTGLAVSHHQGYKSAFAKQQAVIDKMERDKAQALLLSAQN        10        20        30        40        50        60        70        80        90       100       110       120 a735.pepYARELEQARAEAKKYEVKAHAVGMALAKKQAEVSRLKTENKKEIENVLTQDRKNAGGGCI|||||| ||||||||||||||||||||||||||||||||||||||||||||||||:|||| m735YARELELARAEAKKYEVKAHAVGMALAKKQAEVSRLKTENKKEIENVLTQDRKNASGGCI        70        80        90       100       110       120       130       140 a735.pep DGFGHHGLQLYKRALGYGNX |||| ||||||:||||||||m735 DGFGSHGLQLYNRALGYGNX        130       140The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2503>:

g736.seq 1 ATGAATTTTA TCCGTTCCGT CGGGGCGAAA ACCCTCGGCC TTATTCAATC 51CTTCGGCAGT ATCACGCTGT TTCTGCTGAA CATTTTGGCG AAATCCGGCA 101CGGCTTTCGC CCGTCCGCGC CTGAGCGTGC GCCAAGTGTA TTTTGCCGGC 151GTGCTGTCGG TGCTGATTGT TGCCGTTTCG GGGCTGTTCG TCGGTATGGT 201TTTGGGTTTG CAGGGCTATA CGCAGTTGTC GAAATTCAAA TCCGCCGATA 251TTTTGGGCTA TATGGTCGCG GCTTCTCTGT TGCGCGAACT GGGTCCCGTG 301TTGGCGGCGA TTCTGTTTGC CAGCAGCGCG GGCGGTGCGA TGACCAGCGA 351AATCGGTTTG ATGAAAACGA CCGGACAGCT CGAAGCGATG AACGTGATGG 401CGGTCAACCC CGTCGCCCGC GTGGTTGCCC CGCGTTTTTG GGCGGGCGTG 451TTTTCTATGC CGCTTTTGGC TTCGATTTTC AACGTCGCGG GCATTTTCGG 501CGCGTATTTG GTCGGCGTGA GCTGGCTGGG TTTGGACAGC GGTATTTTCT 551GGCCGCAGAT GCAGAACAAC ATTACGATAC ATTACGATGT AATCAACGGT 601TTGATCAAAT CCGCCGCGTT CGGCGTGGCG GTAACGCTGA TTGCCGTGCA 651TCAGGGCTTC CACTGCATCC CGACTTCGGA AGGCATTTTG CGCGCCAGCA 701CGCGCACGGT GGTTTCGTCC GCCCTGACGA TTTTGGCGGT CGATTTTATA 751TTGACCGCGT GGATGTTTAC AGATTGAThis corresponds to the amino acid sequence <SEQ ID 2504; ORF 736>:

g736.pep 1 MNFIRSVGAK TLGLIQSFGS ITLFLLNILA KSGTAFARPR LSVRQVYFAG 51VLSVLIVAVS GLFVGMVLGL QGYTQLSKFK SADILGYMVA ASLLRELGPV 101LAAILFASSA GGAMTSEIGL MKTTGQLEAM NVMAVNPVAR VVAPRFWAGV 151FSMPLLASIF NVAGIFGAYL VGVSWLGLDS GIFWPQMQNN ITIHYDVING 201LIKSAAFGVA VTLIAVHQGF HCIPTSEGIL RASTRTVVSS ALTILAVDFI 251 LTAWMFTD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2505>:

m736.seq 1 ATGAATTTTA TCCGTTCCGT CGGGGCGAAA ACCCTCGGCC TTATTCAATC 51CTTCGGCAGT ATCACGCTGT TTCTGCTGAA CATTTTGGCG AAATCCGGCA 101CGGCTTTCGC CCGTCCGCGC CTGAGCGTGC GCCAAGTGTA TTTTGCCGGC 151GTGCTGTCGG TGCTGATTGT TGCCGTTTCG GGGCTGTTCG TCGGTATGGT 201TTTGGGTTTG CAGGGCTATA CGCAGTTGTC GAAATTCAAA TCCGCCGATA 251TTTTGGGCTA TATGGTCGCG GCTTCTCTGT TGCGCGAACT GGGTCCCGTG 301TTGGCGGCGA TTCTGTTTGC CAGCAGCGCG GGCGGTGCGA TGACCAGCGA 351AATCGGTTTG ATGAAAACGA CCGGACAGCT CGAAGCGATG AACGTGATGG 401CGGTCAACCC CGTCGCCCGC GTGGTTGCCC CGCGTTTTTG GGCGGGCGTG 451TTTTCTATGC CGCTTTTGGC TTCGATTTTC AACGTCGCGG GCATTTTCGG 501CGCGTATTTG GTCGGCGTGA GCTGGCTGGG TTTGGACAGC GGTATTTTCT 551GGCCGCAGAT GCAGAACAAC ATTACGATAC ATTACGATGT AATCAACGGT 601TTGATCAAAT CCGCCGCGTT CGGCGTGGCG GTAACGCTGA TTGCCGTGCA 651TCAGGGCTTC CACTGCATCC CGACTTCGGA AGGCATTTTG CGCGCCAGCA 701CGCGCACGGT GGTTTCGTCC GCCCTGACGA TTTTGGCGGT CGATTTTATA 751TTGACCGCGT GGATGTTTAC AGATTGAThis corresponds to the amino acid sequence <SEQ ID 2506; ORF 736>:

m736.pep 1 MNFIRSVGAK TLGLIQSLGS ITLFLLNILA KSGTAFVRPR LSVRQVYFAG 51VLSVLIVAVS GLFVGMVLGL QGYTQLSKFK SADILGYMVA ASLLRELGPV 101LAAILFASSA GGAMTSEIGL MKTTEQLEAM NVMAVNPVAR VVAPRFWAGV 151FSMPLLASIF NVAGIFGAYL VGVTWLGLDS GIFWSQMQNN ITIHYDVING 201LIKSAAFGVA VTLIAVHQGF HCVPTSEGIL RASTRTVVSS ALTILAVDFI 251 LTAWMFTD*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 736 shows 97.7% identity over a 258 aa overlap with a predicted ORF(ORF736.ng) from N. gonorrhoeae:

m736/g736         10        20        30        40        50        60m736.pep MNFIRSVGAKTLGLIQSLGSITLFLLNILAKSGTAFVRPRLSVRQVYFAGVLSVLIVAVS|||||||||||||||||:||||||||||||||||||:||||||||||||||||||||||| g736MNFIRSVGAKTLGLIQSFGSITLFLLNILAKSGTAFARPRLSVRQVYFAGVLSVLIVAVS        10        20        30        40        50        60        70        80        90       100       110       120 m736.pepGLFVGMVLGLQGYTQLSKFKSADILGYMVAASLLRELGPVLAAILFASSAGGAMTSEIGL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g736GLFVGMVLGLQGYTQLSKFKSADILGYMVAASLLRELGPVLAAILFASSAGGAMTSEIGL        70        80        90       100       110       120       130       140       150       160       170       180 m736.pepMKTTEQLEAMNVMAVNPVARVVAPRFWAGVFSMPLLASIFNVAGIFGAYLVGVTWLGLDS ||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||| g736MKTTGQLEAMNVMAVNPVARVVAPRFWAGVFSMPLLASIFNVAGIFGAYLVGVSWLGLDS       130       140       150       160       170       180       190       200       210       220       230       240 m736.pepGIFWSQMQNNITIHYDVINGLIKSAAFGVAVTLIAVHQGFHCVPTSEGILRASTRTVVSS |||||||||||||||||||||||||||||||||||||||||:||||||||||||||||| g736GIFWPQMQNNITIHYDVINGLIKSAAFGVAVTLIAVHQGFHCIPTSEGILRASTRTVVSS       190       200       210       220       230       240       250       259 m736.pep ALTILAVDFILTAWMFTDX |||||||||||||||||||g736 ALTILAVDFILTAWMFTDX        250The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2507>:

a736.seq 1 ATGAATTTTA TCCGTTCCGT CGGGGCGAAA ACCCTCGGCC TTATTCAATC 51TCTCGGCAGT ATCACGCTGT TTCTGCTGAA TATTCTGGCG AAATCCGGTA 101CGGCTTTCGT CCGTCCGCGC CTGAGCGTGC GCCAAGTGTA TTTTGCCGGC 151GTGCTGTCGG TGTTGATTGT TGCCGTTTCA GGGCTGTTTG TCGGCATGGT 201CTTGGGTTTG CAGGGCTATA CGCAGTTGTC GAAATTCAAA TCCGCCGATA 251TTTTGGGCTA TATGGTCGCG GCTTCGCTGT TGCGCGAACT GGGTCCGGTG 301TTGGCGGCGA TTCTGTTTGC CAGCAGCGCG GGCGGTGCGA TGACCAGCGA 351AATCGGTTTG ATGAAAACGA CCGAACAGCT CGAAGCGATG AACGTGATGG 401CGGTAAACCC CGTCGCCCGA GTGGTTGCGC CGCGCTTTTG GGCGGGCGTG 451TTTTCCATGC CGCTTTTGGC TTCGATTTTC AACGTGGCGG GTATTTTCGG 501CGCGTATTTG GTCGGTGTAA CCTGGCTGGG CTTGGACAGC GGTATTTTCT 551GGTCGCAAAT GCAGAACAAC ATCACGATAC ATTACGATGT AATCAACGGT 601CTGATCAAAT CCGCCGCGTT CGGCGTGGCG GTAACGCTGA TTGCCGTGCA 651TCAGGGCTTC CACTGCGTCC CGACCTCGGA AGGCATTTTG CGCGCCAGCA 701CGCGCACGGT GGTTTCGTCC GCCCTGACGA TTTTGGCGGT CGATTTTATA 751TTGACCGCGT GGATGTTTAC AGATTGAThis corresponds to the amino acid sequence <SEQ ID 2508; ORF 736.a>:

a736.pep 1 MNFIRSVGAK TLGLIQSLGS ITLFLLNILA KSGTAFVRPR LSVRQVYFAG 51VLSVLIVAVS GLFVGMVLGL QGYTQLSKFK SADILGYMVA ASLLRELGPV 101LAAILFASSA GGAMTSEIGL MKTTEQLEAM NVMAVNPVAR VVAPRFWAGV 151FSMPLLASIF NVAGIFGAYL VGVTWLGLDS GIFWSQMQNN ITIHYDVING 201LIKSAAFGVA VTLIAVHQGF HCVPTSEGIL RASTRTVVSS ALTILAVDFI 251 LTAWMFTD*a736/m736 100.0% identity in 258 aa overlap        10        20        30        40        50        60 a736.pepMNFIRSVGAKTLGLIQSLGSITLFLLNILAKSGTAFVRPRLSVRQVYFAGVLSVLIVAVS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m736MNFIRSVGAKTLGLIQSLGSITLFLLNILAKSGTAFVRPRLSVRQVYFAGVLSVLIVAVS        10        20        30        40        50        60        70        80        90       100       110       120 a736.pepGLFVGMVLGLQGYTQLSKFKSADILGYMVAASLLRELGPVLAAILFASSAGGAMTSEIGL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m736GLFVGMVLGLQGYTQLSKFKSADILGYMVAASLLRELGPVLAAILFASSAGGAMTSEIGL        70        80        90       100       110       120       130       140       150       160       170       180 a736.pepMKTTEQLEAMNVMAVNPVARVVAPRFWAGVFSMPLLASIFNVAGIFGAYLVGVTWLGLDS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m736MKTTEQLEAMNVMAVNPVARVVAPRFWAGVFSMPLLASIFNVAGIFGAYLVGVTWLGLDS       130       140       150       160       170       180       190       200       210       220       230       240 a736.pepGIFWSQMQNNITIHYDVINGLIKSAAFGVAVTLIAVHQGFHCVPTSEGILRASTRTVVSS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m736GIFWSQMQNNITIHYDVINGLIKSAAFGVAVTLIAVHQGFHCVPTSEGILRASTRTVVSS       190       200       210       220       230       240       250      259 a736.pep ALTILAVDFILTAWMFTDX |||||||||||||||||||m736 ALTILAVDFILTAWMFTDX        250The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2509>:

g737.seq 1 atgaACATCA AACACCTTCT CTTGACCGCC GCCGCAACCG CACTGTTGGG 51CATTTCCGCC CCCGCACTCG CCCACCACGA CGGACACGGC GATGACGACC 101ACGGACACGC CGCACACCAA CACGGCAAAC AAGACAAAAT CATCAGCCGC 151GCCCAAGCCG AAAAAGCGGC TTGGGCGCGT GTCGGCGGCA AAATCACCGA 201CATCGATCTC GAACACGACG ACGGCCGTCC GCACTATGAT GTCGAAATCG 251TCAAAAACGG ACAGGAATAC AAAGTCGTTG TCGATGCCCG TACCGGCCGC 301GTGATTTCCT CCCGCCGCGA CGACTGAThis corresponds to the amino acid sequence <SEQ ID 2510; ORF 737>:

g737.pep 1 MNIKHLLLTA AATALLGISA PALAHHDGHG DDDHGHAAHQ HGKQDKIISR 51AQAEKAAWAR VGGKITDIDL EHDDGRPHYD VEIVKNGQEY KVVVDARTGR 101 VISSRRDD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2511>:

m737.seq.. 1 ATGAACATCA AACACCTTCT CTTGACCTCC GCCGCAACCG CACTGCTGAG 51CATTTCCGCC CCCGCGCTCG CCCACCACGA CGGACACGGC GATGACGACC 101ACGGACACGC CGCACACCAA CACAACAAAC AAGACAAAAT CATCAGCCGC 151GCCCAAGCCG AAAAAGCAGC GTTGGCGCGT GTCGGCGGCA AAATCACCGA 201CATCGATCTC GAACACGACA ACGGCCGTCC GCACTATGAT GTCGAAATCG 251TCAAAAACGG ACAGGAATAC AAAGTCGTTG TCGATGCCCG TACCGGCCGC 301GTGATTTCCT CCCGCCGCGA CGACTGAThis corresponds to the amino acid sequence <SEQ ID 2512; ORF 737>:

m737.pep 1 MNIKHLLLTS AATALLSISA PALAHHDGHG DDDHGHAAHQ HNKQDKIISR 51AQAEKAALAR VGGKITDIDL EHDNGRPHYD VEIVKNGQEY KVVVDARTGR 101 VISSRRDD*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 737 shows 95.4% identity over a 108 aa overlap with a predicted ORF(ORF737.a) from N. gonorrhoeae:

m737/g737         10        20        30        40        50        60m737.pep MNIKHLLLTSAATALLSISAPALAHHDGHGDDDHGHAAHQHNKQDKIISRAQAEKAALAR|||||||||:||||||:||||||||||||||||||||||||:||||||||||||||| || g737MNIKHLLLTAAATALLGISAPALAHHDGHGDDDHGHAAHQHGKQDKIISRAQAEKAAWAR        10        20        30        40        50        60        70        80        90       100      109 m737.pepVGGKITDIDLEHDNGRPHYDVEIVKNGQEYKVVVDARTGRVISSRRDDX|||||||||||||:||||||||||||||||||||||||||||||||||| g737VGGKITDIDLEHDDGRPHYDVEIVKNGQEYKVVVDARTGRVISSRRDDX        70        80        90       100The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2513>:

a737.seq 1 ATGAACTTCA AACGCCTTCT CTTGACCGCC GCCGCAACCG CACTGATGGG 51CATTTCCGCC CCCGCACTCG CCCACCACGA CGGACACGGC GATGACGACC 101ACGGACACGC CGCACACCAA CACAGCAAAC AAGACAAAAT CATCAGCCGC 151GCCCAAGCCG AAAAAGCAGC GTTGGCGCGT GTCGGCGGCA AAATCACCGA 201CATCGATCTC GAACACGACA ACGGCCGTCC GCACTATGAT GTCGAAATCG 251TCAAAAACGG ACAGGAATAC AAAGTCGTTG TCGATGCCCG TACCGGCCGC 301GTGATTTCCT CCCGCCGCGA CGACTGAThis corresponds to the amino acid sequence <SEQ ID 2514; ORF 737.a>:

a737.pep 1 MNFKRLLLTA AATALMGISA PALAHHDGHG DDDHGHAAHQ HSKQDKIISR 51AQAEKAALAR VGGKITDIDL EHDNGRPHYD VEIVKNGQEY KVVVDARTGR 101 VISSRRDD*a737/m737 94.4% identity in 108 aa overlap        10        20        30        40        50        60 a737.pepMNFKRLLLTAAATALMGISAPALAHHDGHGDDDHGHAAHQHSKQDKIISRAQAEKAALAR||:|:||||:|||||::||||||||||||||||||||||||:|||||||||||||||||| m737MNIKHLLLTSAATALLSISAPALAHHDGHGDDDHGHAAHQHNKQDKIISRAQAEKAALAR        10        20        30        40        50        60        70        80        90       100      109 a737.pepVGGKITDIDLEHDNGRPHYDVEIVKNGQEYKVVVDARTGRVISSRRDDX||||||||||||||||||||||||||||||||||||||||||||||||| m737VGGKITDIDLEHDNGRPHYDVEIVKNGQEYKVVVDARTGRVISSRRDDX        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2515>:

g738.seq 1 ATGTCCGCTG AAACGACCGT ATCCGGCGCG CGCCCCGCCG CCAAACTGCC 51GATTTACATC CTGCCCTGCT TCCTTTGGAT AGGCATCATC CCCTTTACCT 101TCGCACTCAG GCTGAAACCG TCGCCCGACT TTTACCACGA TGCCGCCGCC 151GCGGCCGGCC TGATTGTCCT GTTGTTCCTC ACGGCAGGAA AAAAGCTGTT 201TGATGTCAAA ATCCCCGCCA TCAGCTTCCT CCTGTTTGCA ATGGCGGCAT 251TTTGGTGGCT TCAGGCACGC CTGATGAACC TGATTTATCC CGGAATGAAC 301GACATCGCCT CTTGGGTTTT CATCTTGCTC GCCGTCAGCG CGTGGGCCTG 351CAAGAGTTTG GTCGCACACT ACGGACAAGA ACGCAtcgtT ACCCTGTTTG 401CCTGGTCGCT GCTTATCGGC TCCCTGCTTC AATCCTGCAT CGTcgtCATC 451CAGTTTGCCG GCTGGGAAAA CACCCCCCTG CTTCAAAACA TCATCGTTCA 501CAGAGGGCAA GGCGTAATCG GACACATCGG GCAGCGCAAC AACCTCGGAC 551ACTACCTCAT GTGGGGCATA CTCGCCTCCG CCTACCTCAA CGGACAACGA 601AAAATCCCCG CAGCCCTCGG CGCAATCTGC CTGATTATGC AGACCGCCGT 651TTTAGGTTTG GTCAATTCGC GCACCATCTT GACCTACATA GCCGCCATCG 701CCCTCATCCT TCCCTTCTGG TATTTCCGTT CGGACAAATC CAACAGACGG 751ACGATGCTCG GCATAGCCGC AGCCGTATTC CTTACCGCGC TGTTCCAATT 801TTCCATGAAC GCCATTCTGG AAACCTTTAC AGGCATCCGC TACGAAACTG 851CCGTCGAACG CGTCGCCAAC GGCGGTTTCA CAGACTTGCC GCGCCAAAGC 901GAATGGAATA AAGCCCTTGC CGCCTTCCAG TCCGCCCCGA TATTCGGGCA 951CGGCTGGAAC AGTTTTGCCC AACAAACCTT CCTGATCAAT GCCGAACAGC 1001ACACCATACA CGACAACTTC CTCAGCACCT TGTTCACCCA TTCCCACAAC 1051ATCATCCTCC AACTCCTTGC AGAAATGGGG ATCAGCGGCA CGCTTCTGGT 1101TGCCGCAACC CTGCTGACGG GCATTGCCGG GCTGCTGAAA CGCTCCCTGA 1151CCCCCGCATC ACTTTTCCTG CTGTGCGCGC TTGCCGTCAG TATGTGCCAC 1201AGTATGCTCG AATATCCTTT GTGGTATGTC TATTTCCTCA TCCCCTTCGG 1251ACTGATGCTC TTTCTGTCCC CCGCAGAGGC TTCAGACGGC ATCGCCTTCA 1301AAAAAGCCGC CAATCTCGGC ATACTGACCG CCTCCGCCGC CATATTCGCA 1351GGATTGCTGC ACTTGGACTG GACATACACC CGGCTGGTTA ACTCCTTTTC 1401CCCCGCCGCT GACGACAGTG CCAAAACCCT CAACCGGAAA ATCAACGAAC 1451TGCGCTATAT TTCCGCAAAC AGCCCGATGC TGTCCTTTTA TGCCGACTTC 1501TCCCTCGTAA ACTTCGCCCT GCCGGAATAC CCCGAAACCC AGACTTGGGC 1551GGAAGAAGCA ACCCTCAAAG CACTAAAATA CCGCCCCTAC TCCGCCACCT 1601ACCGCATCGC CCTCTACTTG ATGCGGCAAG GCAAAGTTGC AGAAGCAAAA 1651CAATGGATGC GGGCAACACA GTCCTATTAC CCCTACCTGA TGCCCCGATA 1701CGCCGACGAA ATCCGCAAAC TGCCCGTATG GGCACCGCTG CTGCCCGAAC 1751TGCTCAAAGA CTGCAAAGCC TTCGCCGCCG CTCCCGGCCA TCCGGAAACA 1801AAACCCTGCA AATGAThis corresponds to the amino acid sequence <SEQ ID 2516; ORF 738>:

g738.pep 1 MSAETTVSGA RPAAKLPIYI LPCFLWIGII PFTFALRLKP SPDFYHDAAA 51AAGLIVLLFL TAGKKLFDVK IPAISFLLFA MAAFWWLQAR LMNLIYPGMN 101DIASWVFILL AVSAWACKSL VAHYGQERIV TLFAWSLLIG SLLQSCIVVI 151 QFAGWENTPLLQNIIVHRGQ GVIGHIGQRN NLGHYLMWGI LASAYLNGQR 201KIPAALGAIC LIMQTAVLGL VNSRTILTYI AAIALILPFW YFRSDKSNRR 251TMLGIAAAVF LTALFQFSMN AILETFTGIR YETAVERVAN GGFTDLPRQS 301 EWNKALAAFQSAPIFGHGWN SFAQQTFLIN AEQHTIHDNF LSTLFTHSHN 351 IILQLLAEMGISGTLLVAAT LLTGIAGLLK RSLTPASLFL LCALAVSMCH 401SMLEYPLWYV YFLIPFGLML FLSPAEASDG IAFKKAANLG ILTASAAIFA 451 GLLHLDWTYTRLVNSFSPAA DDSAKTLNRK INELRYISAN SPMLSFYADF 501 SLVNFALPEY PETQTWAEEATLKALKYRPY SATYRIALYL MRQGKVAEAK 551 QWMRATQSYY PYLMPRYADE IRKLPVWAPLLPELLKDCKA FAAAPGHPET 601 KPCK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2517>:

m738.seq 1 ATGCCCGCTG AAACGACCGT ATCCGGCGCG CACCCCGCCG CCAAACTGCC 51GATTTACATC CTGCCCTGCT TCCTTTGGAT AGGCATCGTC CCCTTTACCT 101 TCGCGCTCAAACTGAAACCG TCGCCCGACT TTTACCACGA TGCCGCCGCC 151 GCAGCCGGCC TGATTGTCCTGTTGTTCCTC ACGGCAGGAA AAAAACTGTT 201 TGATGTCAAA ATCCCCGCCA TCAGCTTCCTTCTGTTTGCA ATGGCGGCGT 251 TTTGGTATCT TCAGGCACGC CTGATGAACC TGATTTACCCCGGTATGAAC 301 GACATCGTCT CTTGGATTTT CATCTTGCTC GCCGTCAGCG CGTGGGCCTG351 CCGGAGCTTG GTCGCACACT TCGGACAAGA ACGCATCGTG ACCCTGTTTG 401CCTGGTCGCT GCTTATCGGC TCCCTGCTTC AATCCTGCAT CGTCGTCATC 451 CAGTTTGCCGGCTGGGAAGA CACCCCTCTG TTTCAAAACA TCATCGTTTA 501 CAGCGGGCAA GGCGTAATCGGACACATCGG GCAGCGCAAC AACCTCGGAC 551 ACTACCTCAT GTGGGGCATA CTCGCCGCCGCCTACCTCAA CGGACAACGA 601 AAAATCCCCG CCGCCCTCGG CGTAATCTGC CTGATTATGCAGACCGCCGT 651 TTTAGGTTTG GTCAACTCGC GCACCATCTT GACCTACATA GCCGCCATCG701 CCCTCATCCT TCCCTTCTGG TATTTCCGTT CGGACAAATC CAACAGGCGG 751ACGATGCTCG GCATAGCCGC AGCCGTATTC CTTACCGCGC TGTTCCAATT 801 TTCCATGAACACCATTCTGG AAACCTTTAC TGGCATCCGC TACGAAACTG 851 CCGTCGAACG CGTCGCCAACGGCGGTTTCA CAGACTTGCC GCGCCAAATC 901 GAATGGAATA AAGCCCTTGC CGCCTTCCAGTCCGCCCCGA TATTCGGGCA 951 CGGCTGGAAC AGTTTTGCCC AACAAACCTT CCTCATCAATGCCGAACAGC 1001 ACAACATATA CGACAACCTC CTCAGCAACT TGTTCACCCA TTCCCACAAC1051 ATCGTCCTCC AACTCCTTGC AGAGATGGGA ATCAGCGGCA CGCTTCTGGT 1101TGCCGCAACC CTGCTGACGG GCATTGCCGG GCTGCTTAAA CGCCCCCTGA 1151 CCCCCGCATCGCTTTTCCTA ATCTGCACGC TTGCCGTCAG TATGTGCCAC 1201 AGTATGCTCG AATATCCTTTGTGGTATGTC TATTTCCTCA TCCCTTTCGG 1251 ACTGATGCTC TTCCTGTCCC CCGCAGAGGCTTCAGACGGC ATCGCCTTCA 1301 AAAAAGCCGC CAATCTCGGC ATACTGACCG CCTCCGCCGCCATATTCGCA 1351 GGATTGCTGC ACTTGGACTG GACATACACC CGGCTGGTTA ACGCCTTTTC1401 CCCCGCCACT GACGACAGTG CCAAAACCCT CAACCGGAAA ATCAACGAGT 1451TGCGCTATAT TTCCGCAAAC AGTCCGATGC TGTCCTTTTA TGCCGACTTC 1501 TCCCTCGTAAACTTCGCCCT GCCGGAATAC CCCGAAACCC AGACTTGGGC 1551 GGAAGAAGCA ACCCTCAAATCACTAAAATA CCGCCCCCAC TCCGCCACCT 1601 ACCGCATCGC CCTCTACCTG ATGCGGCAAGGCAAAGTTGC AGAAGCAAAA 1651 CAATGGATGC GGGCGACACA GTCCTATTAC CCgTACCTGATGCCCCGATA 1701 CGCCGACGAA ATCCGCAAAC TGCCCGTATG GGCGCCGCTG CTACCCGAAC1751 TGCTCAAAGA CTGCAAAGCC TTCGCCGCCG CGCCCGGTCA TCCGGAAGCA 1801AAACCCTGCA AATGAThis corresponds to the amino acid sequence <SEQ ID 2518; ORF 738>:

m738.pep 1 MPAETTVSGA HPAAKLPIYI LPCFLWIGIV PFTFALKLKP SPDFYHDAAA 51AAGLIVLLFL TAGKKLFDVK IPAISFLLFA MAAFWYLQAR LMNLIYPGMN 101DIVSWIFILL AVSAWACRSL VAHFGQERIV TLFAWSLLIG SLLQSCIVVI 151 QFAGWEDTPLFQNIIVYSGQ GVIGHIGQRN NLGHYLMWGI LAAAYLNGQR 201KIPAALGVIC LIMQTAVLGL VNSRTILTYI AAIALILPFW YFRSDKSNRR 251TMLGIAAAVF LTALFQFSMN TILETFTGIR YETAVERVAN GGFTDLPRQI 301 EWNKALAAFQSAPIFGHGWN SFAQQTFLIN AEQHNIYDNL LSNLFTHSHN 351 IVLQLLAEMGISGTLLVAAT LLTGIAGLLK RPLTPASLFL ICTLAVSMCH 401SMLEYPLWYV YFLIPFGLML FLSPAEASDG IAFKKAANLG ILTASAAIFA 451 GLLHLDWTYTRLVNAFSPAT DDSAKTLNRK INELRYISAN SPMLSFYADF 501 SLVNFALPEY PETQTWAEEATLKSLKYRPH SATYRIALYL MRQGKVAEAK 551 QWMRATQSYY PYLMPRYADE IRKLPVWAPLLPELLKDCKA FAAAPGHPEA 601 KPCK*Computer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 738 shows 95.0% identity over a 604 aa overlap with a predicted ORF(ORF738.a) from N. gonorrhoeae:

m738/g738         10        20        30        40        50        60m738.pep MPAETTVSGAHPAAKLPIYILPCFLWIGIVPFTFALKLKPSPDFYHDAAAAAGLIVLLFL| ||||||||:||||||||||||||||||:||||||:||||||||||||||||||||||| g738MSAETTVSGARPAAKLPIYILPCFLWIGIIPFTFALRLKPSPDFYHDAAAAAGLIVLLFL        10        20        30        40        50        60        70        80        90       100       110       120 m738.pepTAGKKLFDVKIPAISFLLFAMAAFWYLQARLMNLIYPGMNDIVSWIFILLAVSAWACRSL|||||||||||||||||||||||||:||||||||||||||||:||:|||||||||||:|| g738TAGKKLFDVKIPAISFLLFAMAAFWWLQARLMNLIYPGMNDIASWVFILLAVSAWACKSL        70        80        90       100       110       120       130       140       150       160       170       180 m738.pepVAHFGQERIVTLFAWSLLIGSLLQSCIVVIQFAGWEDTPLFQNIIVYSGQGVIGHIGQRN|||:||||||||||||||||||||||||||||||||:|||:|||||: |||||||||||| g738VAHYGQERIVTLFAWSLLIGSLLQSCIVVIQFAGWENTPLLQNIIVHRGQGVIGHIGQRN       130       140       150       160       170       180       190       200       210       220       230       240 m738.pepNLGHYLMWGILAAAYLNGQRKIPAALGVICLIMQTAVLGLVNSRTILTYIAAIALILPFW||||||||||||:||||||||||||||:|||||||||||||||||||||||||||||||| g738NLGHYLMWGILASAYLNGQRKIPAALGAICLIMQTAVLGLVNSRTILTYIAAIALILPFW       190       200       210       220       230       240       250       260       270       280       290       300 m738.pepYFRSDKSNRRTMLGIAAAVFLTALFQFSMNTILETFTGIRYETAVERVANGGFTDLPRQI||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||| g738YFRSDKSNRRTMLGIAAAVFLTALFQFSMNAILETFTGIRYETAVERVANGGFTDLPRQS       250       260       270       280       290       300       310       320       330       340       350       360 m738.pepEWNKALAAFQSAPIFGHGWNSFAQQTFLINAEQHNIYDNLLSNLFTHSHNIVLQLLAEMG||||||||||||||||||||||||||||||||||:|:||:||:||||||||:|||||||| g738EWNKALAAFQSAPIFGHGWNSFAQQTFLINAEQHTIHDNFLSTLFTHSHNIILQLLAEMG       310       320       330       340       350       360       370       380       390       400       410       420 m738.pepISGTLLVAATLLTGIAGLLKRPLTPASLFLICTLAVSMCHSMLEYPLWYVYFLIPFGLML||||||||||||||||||||| ||||||||:|:||||||||||||||||||||||||||| g738ISGTLLVAATLLTGIAGLLKRSLTPASLFLLCALAVSMCHSMLEYPLWYVYFLIPFGLML       370       380       390       400       410       420       430       440       450       460       470       480 m738.pepFLSPAEASDGIAFKKAANLGILTASAAIFAGLLHLDWTYTRLVNAFSPATDDSAKTLNRK||||||||||||||||||||||||||||||||||||||||||||:||||:|||||||||| g738FLSPAEASDGIAFKKAANLGILTASAAIFAGLLHLDWTYTRLVNSFSPAADDSAKTLNRK       430       440       450       460       470       480       490       500       510       520       530       540 m738.pepINELRYISANSPMLSFYADFSLVNFALPEYPETQTWAEEATLKSLKYRPHSATYRIALYL|||||||||||||||||||||||||||||||||||||||||||:|||||:|||||||||| g738INELRYISANSPMLSFYADFSLVNFALPEYPETQTWAEEATLKALKYRPYSATYRIALYL       490       500       510       520       530       540       550       560       570       580       590       600 m738.pepMRQGKVAEAKQWMRATQSYYPYLMPRYADEIRKLPVWAPLLPELLKDCKAFAAAPGHPEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: g738MRQGKVAEAKQWMRATQSYYPYLMPRYADEIRKLPVWAPLLPELLKDCKAFAAAPGHPET       550       560       570       580       590       600 m738.pepKPCKX ||||| g738 KPCKXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2519>:

a738.seq 1 ATGCCCGCTG AAACGACCGT ATCCGGCGCG CACCCCGCCG CCAAACTGCC 51GATTTACATC CTGCCCTGCT TCCTTTGGAT AGGCATCGTC CCCTTTACCT 101 TTGCGCTCAGGCTGCAACCG TCGCCCGACT TTTACCACGA TGCCGCCGCC 151 GCAGCCGGCC TGATTGTCCTGTTGTTCCTC ACGGCAGGAA AAAAGCTGTT 201 TGATGTCAAA ATCCCACCTA TCAGCTTCCTTCTGTTTGCA ATGGCGGCGT 251 TTTGGTATCT TCAGGCACGC CTGATGAACC TGATTTACCCCGGTATGAAC 301 GACATCGTCT CTTGGATTTT CATCTTACTC GCCGTCAGCG CGTGGGCCTG351 CCGGAGCTTG GTCGCACACT ACGGACAAGA ACGCATCGTT ACCCTGTTTG 401CCTGGTCGCT GCTTATCGGC TCCCTGCTTC AATCCTGCAT CGTCGTCATC 451 CAGTTTGCCGGCTGGGAAGA CACCCCTCTG TTTCAAAACA TCATTGTTTA 501 CAGCGGGCAA GGCGTAATCGGACACATCGG ACAGCGCAAC AACCTCGGAC 551 ACTACCTCAT GTGGGGCATA CTCGCCGCCGCCTACCTCAA CGGACAACGA 601 AAAATCCCGC CCGCCTTGGG TGCAATCTGC CTGATTATGCAGACCGCCGT 651 TTTAGGTTTG GTCAATTCGC GCACCATCTT GACCTACATA GCCGCCATCG701 CCCTCATCCT TCCCTTCTGG TATTTCCGTT CGGACAAATC CAACAGGCGG 751ACGATACTCG GCATAGCCGC AGCCGTATTC CTTACCGCGC TGTTCCAATT 801 TTCCATGAACACCATTCTGG AAACCTTTAC CGGCATCCGC TACGAAACCG 851 CCGTCGAACG CGTCGCCAACGGCGGTTTCA CAGACCTGCC GCGCCAAATC 901 GAATGGCGCA AAGCCCTCGC CGCCTTCCAGTCCGCCCCGA TATTCGGGCA 951 CGGCTGGAAC AGTTTTGCCC AACAAACCTT CCTCATCAATGCCGAACAGC 1001 ACAACATACA CGACAACCTC CTCAGCAACT TGTTCACCCA TTCCCACAAC1051 ATCGTTCTCC AACTCCTTGC AGAGATGGGG ATCAGCGGCA CGCTTCTGGT 1101TGCCGCAACC CTGCTGACGG GCATTGCCGG GCTGCTGAAA CGCCCCCTGA 1151 CCCCCGCATCGCTTTTCCTG ATCTGCACAC TTGCCGTCAG TATGTGCCAC 1201 AGTATGCTCG AATATCCTTTGTGGTATGTC TATTTCCTCA TCCCCTTCGG 1251 ACTGATGCTC TTTCTGTCCC CCGCAGAGGCTTCAGACGGC ATCGCCTTCA 1301 AAAAAGCCGC CAATCTCGGC ATACTAACCG CCTCCGCCGCCATATTCGCA 1351 GGATTGCTGC ACTTGGACTG GACATACACC CGGATGGTTA ACGCCTTTTC1401 CCCCGCCACT GACGACAGTG CCAAAACCCT CAACCGGAAA ATCAACGAGT 1451TGCGCTATAT TTCCGCAAAC AGTCCGATGC TGTCCTTTTA TGCCGACTTC 1501 TCCCTCGTAAACTTCGCCCT GCCGGAATAC CCCGAAACCC AGACTTGGGC 1551 GGAAGAAGCA ACCCTCAAATCACTAAAATA CCGCCCCCAC TCCGCCACCT 1601 ACCGCATCGC CCTCTACCTG ATGCGGCAAGGCAAAGTTGC AGAAGCAAAA 1651 CAATGGATGC GGGCGACACA GTCCTATTAC CCCTACCTGATGCCCCGATA 1701 CGCCGACGAA ATCCGCAAAC TGCCCGTATG GGCGCCGCTG CTACCCGAAC1751 TGCTCAAAGA CTGCAAAGCC TTCGCCGCCG CGCCCGGTCA TCCGGAAGCA 1801AAACCCTGCA AATGAThis corresponds to the amino acid sequence <SEQ ID 2520; ORF 738.a>:

a738.pep 1 MPAETTVSGA HPAAKLPIYI LPCFLWIGIV PFTFALRLQP SPDFYHDAAA 51AAGLIVLLFL TAGKKLFDVK IPPISFLLFA MAAFWYLQAR LMNLIYPGMN 101DIVSWIFILL AVSAWACRSL VAHYGQERIV TLFAWSLLIG SLLQSCIVVI 151 QFAGWEDTPLFQNIIVYSGQ GVIGHIGQRN NLGHYLMWGI LAAAYLNGQR 201KIPPALGAIC LIMQTAVLGL VNSRTILTYI AAIALILPFW YFRSDKSNRR 251TILGIAAAVF LTALFQFSMN TILETFTGIR YETAVERVAN GGFTDLPRQI 301 EWRKALAAFQSAPIFGHGWN SFAQQTFLIN AEQHNIHDNL LSNLFTHSHN 351 IVLQLLAEMGISGTLLVAAT LLTGIAGLLK RPLTPASLFL ICTLAVSMCH 401SMLEYLWYV YFLIPFGLML FLSPAEASDG IAFKKAANLG ILTASAAIFA 451 GLLHLDWTYTRMVNAFSPAT DDSAKTLNRK INELRYISAN SPMLSFYADF 501 SLVNFALPEY PETQTWAEEATLKSLKYRPH SATYRIALYL MRQGKVAEAK 551 QWMRATQSYY PYLMPRYADE IRKLPVWAPLLPELLKDCKA FAAAPGHPEA 601 KPCK* a738/m738 98.3% identity in 604 aaoverlap         10        20        30        40        50        60a738.pep MPAETTVSGAHPAAKLPIYILPCFLWIGIVPFTFALRLQPSPDFYHDAAAAAGLIVLLFL||||||||||||||||||||||||||||||||||||:|:||||||||||||||||||||| m738MPAETTVSGAHPAAKLPIYILPCFLWIGIVPFTFALKLKPSPDFYHDAAAAAGLIVLLFL        10        20        30        40        50        60        70        80        90       100       110       120 a738.pepTAGKKLFDVKIPPISFLLFAMAAFWYLQARLMNLIYPGMNDIVSWIFILLAVSAWACRSL|||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||| m738TAGKKLFDVKIPAISFLLFAMAAFWYLQARLMNLIYPGMNDIVSWIFILLAVSAWACRSL        70        80        90       100       110       120       130       140       150       160       170       180 a738.pepVAHYGQERIVTLFAWSLLIGSLLQSCIVVIQFAGWEDTPLFQNIIVYSGQGVIGHIGQRN|||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||| m738VAHFGQERIVTLFAWSLLIGSLLQSCIVVIQFAGWEDTPLFQNIIVYSGQGVIGHIGQRN       130       140       150       160       170       180       190       200       210       220       230       240 a738.pepNLGHYLMWGILAAAYLNGQRKIPPALGAICLIMQTAVLGLVNSRTILTYIAAIALILPFW||||||||||||||||||||||| |||:|||||||||||||||||||||||||||||||| m738NLGHYLMWGILAAAYLNGQRKIPAALGVICLIMQTAVLGLVNSRTILTYIAAIALILPFW       190       200       210       220       230       240       250       260       270       280       290       300 a738.pepYFRSDKSNRRTILGIAAAVFLTALFQFSMNTILETFTGIRYETAVERVANGGFTDLPRQI|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||| m738YFRSDKSNRRTMLGIAAAVFLTALFQFSMNTILETFTGIRYETAVERVANGGFTDLPRQI       250       260       270       280       290       300       310       320       330       340       350       360 a738.pepEWRKALAAFQSAPIFGHGWNSFAQQTFLINAEQHNIHDNLLSNLFTHSHNIVLQLLAEMG|| |||||||||||||||||||||||||||||||||:||||||||||||||||||||||| m738EWNKALAAFQSAPIFGHGWNSFAQQTFLINAEQHNIYDNLLSNLFTHSHNIVLQLLAEMG       310       320       330       340       350       360       370       380       390       400       410       420 a738.pepISGTLLVAATLLTGIAGLLKRPLTPASLFLICTLAVSMCHSMLEYPLWYVYFLIPFGLML|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m738ISGTLLVAATLLTGIAGLLKRPLTPASLFLICTLAVSMCHSMLEYPLWYVYFLIPFGLML       370       380       390       400       410       420       430       440       450       460       470       480 a738.pepFLSPAEASDGIAFKKAANLGILTASAAIFAGLLHLDWTYTRMVNAFSPATDDSAKTLNRK|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| m738FLSPAEASDGIAFKKAANLGILTASAAIFAGLLHLDWTYTRLVNAFSPATDDSAKTLNRK       430       440       450       460       470       480       490       500       510       520       530       540 a738.pepINELRYISANSPMLSFYADFSLVNFALPEYPETQTWAEEATLKSLKYRPHSATYRIALYL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m738INELRYISANSPMLSFYADFSLVNFALPEYPETQTWAEEATLKSLKYRPHSATYRIALYL       490       500       510       520       530       540       550       560       570       580       590       600 a738.pepMRQGKVAEAKQWMRATQSYYPYLMPRYADEIRKLPVWAPLLPELLKDCKAFAAAPGHPEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m738MRQGKVAEAKQWMRATQSYYPYLMPRYADEIRKLPVWAPLLPELLKDCKAFAAAPGHPEA       550       560       570       580       590       600 a738.pepKPCKX ||||| m738 KPCKXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2521>:

g739.seq 1 ATGGCAAAAA AACCGAACAA ACCCTTCAGG CTGACCCCCA AACTCCTGAT 51ACGCGCCGTA TTGCTCATCT GTATCACCGC CATCGGCGCA TTGGCAGTAG 101 GCATCGTCAGCACATTCAAC CCGAACGGCG ACAAAACCCT CCAAACCGAA 151 CCGCAACACA CCGACAGCCCCCGCGAAACC GAATTCTGGC TGCCAAACGG 201 CGCCGTCGGA CAAGATGCCG CCCAACCCGAACACCACCAC GCCGCCTCAT 251 CCGAACCCGC ACAGCCGGAC GGCACAGAAG AAAGCGGCAGCGGACTGCCG 301 TCCCCTGCCG CACCCAAGAA AAACCGGGTc AAACCGCGCC CTTCGGATGC351 GGCCCGGGCA GCCGATTCGT TAACCGGCAC CGGAACACAA GCTGAAAACA 401CACTCAAAGA AACCCCCGTA CTGCCCACAA ACGCCCCCCA TCCCGAACCC 451 CGAAAAGAAACACCCGAAAA ACAGGCGCAG CCCAAAGAAA CACCCAAAGA 501 AAAAGAAACG CCCAAAGAAAACCATACCAA ACCGGACACC CCGAAAAACA 551 CGCCGGCCAA ACCCCATAAA GAGATTCTCGACAACCTCTT TTGAThis corresponds to the amino acid sequence <SEQ ID 2522; ORF 739>:

g739.pep 1 MAKKPNKPFR LTPKLLIRAV LLICITAIGA LAVGIVSTFN PNGDKTLQTE 51PQHTDSPRET EFWLPNGAVG QDAAQPEHHH AASSEPAQPD GTEESGSGLP 101 SPAAPKKNRVKPRPSDAARA ADSLTGTGTQ AENTLKETPV LPTNAPHPEP 151 RKETPEKQAQ PKETPKEKETPKENHTKPDT PKNTPAKPHK EILDNLF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2523>:

m739.seq 1 ATGGCAAAAA AACCGAACAA ACCCTTCAGG CTGACCCCCA AACTCCTGAT 51ACGCGCCGTA TTGCTCATCT GTATCGCCGC CATCGGCGCA TTGGCAATAG 101 GCATCGTCAGCACATTCAAC CCGAACGGCG ACAAAACCCT TCAAGCCGAA 151 CCGCAACACA CCGACAGCCCCCGCGAAACC GAATTCTGGC TGCCAAACGG 201 CGTAGTCGGA CAAGATGCCG CCCAACCCGAACACCACCAC GCCGCCTCAT 251 CCGAACCCGC ACAGCCGGAC GGCACAGACG AAAGCGGCAGCGGACTGCCG 301 TCCCCTGCCG CACCCAAGAA AAACCGGGTC AAACCGCAAC CTGCCGACAC351 AGCTCAAACC GACAGGCAGC CGGACGACGC CGGAACACAA GCTGAAAACA 401CACTCAAAGA AACCCCCGTA CTGCCCACAA ACGTCCCCCG TCCCGAACCC 451 CGAAAAGAAACACCCGAAAA ACAGGCGCAG CCCAAAGAAA CGCCCAAAGA 501 AAACCATACC AAACCGGACACCCCGAAAAA CACGCCGCCC AAACCCCATA 551 AAGAAATTCT CGACAAACTC TTCThis corresponds to the amino acid sequence <SEQ ID 2524; ORF 739>:

m739.pep 1 MAKKPNKPFR LTPKLLIRAV LLICIAAIGA LAIGIVSTFN PNGDKTLQAE 51PQHTDSPRET EFWLPNGVVG QDAAQPEHHH AASSEPAQPD GTDESGSGLP 101 SPAAPKKNRVKPQPADTAQT DRQPDDAGTQ AENTLKETPV LPTNVPRPEP 151 RKETPEKQAQ PKETPKENHTKPDTPKNTPP KPHKEILDKL FComputer analysis of the amino acid sequences gave the followingresults:Homology with a Predicted ORF from N. meningitidis menA with menBORF 739 shows 86.3% identity over a 197 aa overlap with a predicted ORF(ORF739.a) from N. gonorrhoeae:

m739/g739         10        20        30        40        50        60m739.pep MAKKPNKPFRLTPKLLIRAVLLICIAAIGALAIGIVSTFNPNGDKTLQAEPQHTDSPRET|||||||||||||||||||||||||:||||||:|||||||||||||||:||||||||||| g739MAKKPNKPFRLTPKLLIRAVLLICITAIGALAVGIVSTFNPNGDKTLQTEPQHTDSPRET        10        20        30        40        50        60        70        80        90       100       110       120 m739.pepEFWLPNGVVGQDAAQPEHHHAASSEPAQPDGTDESGSGLPSPAAPKKNRVKPQPADTAQT|||||||:||||||||||||||||||||||||:|||||||||||||||||||:|:|:|:: g739EFWLPNGAVGQDAAQPEHHHAASSEPAQPDGTEESGSGLPSPAAPKKNRVKPRPSDAARA        70        80        90       100       110       120       130       140       150       160             170 m739.pepDRQPDDAGTQAENTLKETPVLPTNVPRPEPRKETPEKQAQPKETPKE------NHTKPDT  :   :|||||||||||||||||:|:||||||||||||||||||||      ||||||| g739ADSLTGTGTQAENTLKETPVLPTNAPHPEPRKETPEKQAQPKETPKEKETPKENHTKPDT       130       140       150       160       170       180   180       190 m739.pep PKNTPPKPHKEILDKLF ||||| ||||||||:|| g739PKNTPAKPHKEILDNLFX        190The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2525>:

a739.seq 1 ATGGCAAAAA AACCGAACAA ACCCTTCAGG CTGACCCCCA AACTCCTGAT 51ACGCGCCGTA TTGCTCATCT GTATCACCGC CATCGGCGCA TTGGCAATAG 101 GCATCGTCAGCACATTCAAC CCGAACGGCG ACAAAACCCT CCAAACCGAA 151 CCGCAACACA CCGACAGCCCCCGCGAAACC GAATTCTGGC TGCCAAACGG 201 CGTAGTCGGA CAAGATGCCG CCCAACCCGAACACCACCAC GCCTCCTCAT 251 CCGCACCCGC ACAGCCGGAC GGCACAGACG AAAGCGGCAGCGGACTGCCG 301 TCCCCTGCCG CACCCAAGAA AAACCGGGTC AAACCGCAAC CTGCCGACAC351 AGCTCAAACC GACAGGCAGC CGGACGACGC CGGAGCACAA GCTGAAAACA 401CACTCAAAGA AACCCCCGTA CTGCCCACAA ACGTCCCCCG TCCCGAACCC 451 CGAAAAGAAACACCCGAAAA ACAGGCACAG CCCAAAGAAA CACCCAAAGA 501 AAAAGAAACG CCCAAAGAAAACCATACCAA ACCGGACACC CCGAAAAACA 551 CGCCGCCTAA ACCCCATAAA GAAATTCTCGACAACCTCTT CTGAThis corresponds to the amino acid sequence <SEQ ID 2526; ORF 739.a>:

a739.pep 1 MAKKPNKPFR LTPKLLIRAV LLICITAIGA LAIGIVSTFN PNGDKTLQTE 51PQHTDSPRET EFWLPNGVVG QDAAQPEHHH ASSSAPAQPD GTDESGSGLP 101 SPAAPKKNRVKPQPADTAQT DRQPDDAGAQ AENTLKETPV LPTNVPRPEP 151 RKETPEKQAQ PKETPKEKETPKENHTKPDT PKNTPPKPHK EILDNLF* a739/m739 93.9% identity in1 97 aaoverlap         10        20        30        40        50        60a739.pep MAKKPNKPFRLTPKLLIRAVLLICITAIGALAIGIVSTFNPNGDKTLQTEPQHTDSPRET|||||||||||||||||||||||||:||||||||||||||||||||||:||||||||||| m739MAKKPNKPFRLTPKLLIRAVLLICIAAIGALAIGIVSTFNPNGDKTLQAEPQHTDSPRET        10        20        30        40        50        60        70        80        90       100       110       120 a739.pepEFWLPNGVVGQDAAQPEHHHASSSAPAQPDGTDESGSGLPSPAAPKKNRVKPQPADTAQT|||||||||||||||||||||:|| ||||||||||||||||||||||||||||||||||| m739EFWLPNGVVGQDAAQPEHHHAASSEPAQPDGTDESGSGLPSPAAPKKNRVKPQPADTAQT        70        80        90       100       110       120       130       140       150       160       170       180 a739.pepDRQPDDAGAQAENTLKETPVLPTNVPRPEPRKETPEKQAQPKETPKEKETPKENHTKPDT||||||||:|||||||||||||||||||||||||||||||||||||      |||||||| m739DRQPDDAGTQAENTLKETPVLPTNVPRPEPRKETPEKQAQPKETPK------ENHTKPDT       130       140       150       160             170        190a739.pep PKNTPPKPHKEILDNLFX ||||||||||||||:|| m739 PKNTPPKPHKEILDKLF   180       190The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2527>:

g740.seq 1 ATGTCCCGAA ACCTGCTTGT CCGCTGGCTC GCCGTCTGCC TCATCCCCTT 51GgcgACGCTT GCCGTTTTCG CCGCCAATcc gcCCGAAGAC AAACCCCAGC 101 ATCTGATCAACGGCATCATC CTTGCCTGCG AAGCGACGTT TTTGTTTAAa 151 ttcgtgctCT TTGAAACCATCAAGCATCAT CTTAaacaag gGTTTGATTT 201 GAAACgtcaa ACCATGTTTC TGTTTATTCCGATTGTTTTG CTGGTTGTGT 251 ATTTGTTCCA CTATTTCGGC GCGTTTTagThis corresponds to the amino acid sequence <SEQ ID 2528; ORF 740.ng>:

g740.pep 1 MSRNLLVRWL AVCLIPLATL AVFAANPPED KPQHLINGII LACEATFLFK 51FVLFETIKHH LKQGFDLKRQ TMFLFIPIVL LVVYLFHYFG AF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2529>:

m740.seq 1 ATGTCCCGAA ACCTGCTTGT CCGCTGGCTT GCCGTCTGCC TCATCCCGTT 51GGCGACGCTT GCCGTTTTCG CCGCCAATCC GCCCGAAGAC AAACTCCAGC 101 ATCTGATCAACGGCATCATC CTTGCCTGCG AAGCGACGTT TTTGTTTAAA 151 TTCGTCCTTT TCGACACCATCAAGCATCAT TTGAAACAAG AGTTTGATTT 201 GAAACGTCAA ACTATGTTGC TGTTTATTCCGATTATTTTG CTGATTGTGT 251 ATTTGTTCCA CTATTTTGGC GCGTTTTAGThis corresponds to the amino acid sequence <SEQ ID 2530; ORF 740>:

m740.pep 1 MSRNLLVRWL AVCLIPLATL AVFAANPPED KLQHLINGII LACEATFLFK 51FVLFDTIKHH LKQEFDLKRQ TMLLFIPIIL LIVYLFHYFG AF* m740/g740 93.5% identityin 92 aa overlap        10        20        30        40        50        60 m740.pepMSRNLLVRWLAVCLIPLATLAVFAANPPEDKLQHLINGIILACEATFLFKFVLFDTIKHH||||||||||||||||||||||||||||||| ||||||||||||||||||||||:||||| g740MSRNLLVRWLAVCLIPLATLAVFAANPPEDKPQHLINGIILACEATFLFKFVLFETIKHH        10        20        30        40        50        60        70        80        90 m740.pepLKQEFDLKRQTMLLFIPIILLIVYLFHYFGAFX ||| ||||||||:|||||:||:||||||||||| g740LKQGFDLKRQTMFLFIPIVLLVVYLFHYFGAFX         70        80        90The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2531>:

a740.seq 1 ATGTCCCGAA ACCTGCTTGT CCGCTGGCTT GTCGTCTGCC TGATACCCTT 51GGCGACGCTT GCCGTTTTCG CCGCCAATCC GCCCGAAGAC AAACCCCAGC 101 ATCTGATTAACGGCATCATC CTTGCCTGCG AAGCGACGTT TTTGTTCAAA 151 TTCGTCCTTT TCGACACCATCAAGCATCAT TTGAAACAAG AGTTTGATTT 201 GAAACGTCAA ACTATGTTGC TGTTTATTCCGATTATTTTG CTGATTGTGT 251 ATTTGTTCCA CTATTTTGGC GCGTTTTAGThis corresponds to the amino acid sequence <SEQ ID 2532; ORF 740.a>:

a740.pep 1 MSRNLLVRWL VVCLIPLATL AVFAANPPED KPQHLINGII LACEATFLFK 51FVLFDTIKHH LKQEFDLKRQ TMLLFIPIIL LIVYLFHYFG AF* a740/m740 97.8% identityin 92 aa overlap        10        20        30        40        50        60 a740.pepMSRNLLVRWLVVCLIPLATLAVFAANPPEDKPQHLINGIILACEATFLFKFVLFDTIKHH||||||||||:|||||||||||||||||||| |||||||||||||||||||||||||||| m740MSRNLLVRWLAVCLIPLATLAVFAANPPEDKLQHLINGIILACEATFLFKFVLFDTIKHH        10        20        30        40        50        60        70        80        90 a740.pepLKQEFDLKRQTMLLFIPIILLIVYLFHYFGAFX ||||||||||||||||||||||||||||||||| m740LKQEFDLKRQTMLLFIPIILLIVYLFHYFGAFX         70        80        90The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2533>:

g741.seq 1 GTGAACCGAA CTACCTTCTG CTGCCTTTCT TTGACCGCCG GCCCTGATTC 51TGACCGCCTG CAGCAGCGGA GGGGCGGAGG CGGTGGTGTC GCCGCCGACA 101 TCGGCACGGGGCTTGCCGAT GCATTAACCG CGCCGCTCGA CCATAAAGAC 151 AAAGGTTTGA AATCCCTAACATTGGAAGCC TCCATTCCCC AAAACGGAAC 201 ACTGACCCTG TCGGCACAAG GTGCGGAAAAAACTTTCAAA GCCGGCGGCA 251 AAGACAACAG CCTCAACACG GGCAAACTGA AGAACGACAAAATCAGCCGC 301 TTCGACTTCG TGCAAAAAAT CGAAGTGGAC GGACAAACCA TCACACTGGC351 AAGCGGCGAA TTTCAAATAT ACAAACAGGA TCACTCCGcc gtcgtTgcCC 401TacgGATTGA AAAAATCAAC AACCCCGACA AAATCGACAG CCTGATAAAC 451 CAACGCTCCTTCCTTGTCAG CGATTTGGGC GGAGAACATA CCGCCTTCAA 501 CCAACTGCCT GACGGCAAAGCCGAGTATCA CGGCAAAGCA TTCAGCTCCG 551 ACGATGCCGA CGGAAAACTG ACCTATACCATAGATTTCGC CGCCAAACAG 601 GGACACGGCA AAATCGAACA CCTGAAAACA CCCGAGCAGAATGTTGAGCT 651 TGCCTCCGCC GAACTCAAAG CAGATGAAAA ATCACACGCC GTCATTTTGG701 GCGACACGCG CTACGGCGGC GAAGAGAAAG GCACTTACCG CCTCGCCCTT 751TTCGGCGACC GCGCCCAAGA AATCGCTGGC TCGGCAACCG TGAAGATAGG 801 GGAAAAGGTTCACGAAATCG GCATCGCCGA CAAACAGTAGThis corresponds to the amino acid sequence <SEQ ID 2534; ORF 741.ng>:

g741.pep 1 VNRTTFCCLS LTAGPDSDRL QQRRGGGGGV AADIGTGLAD ALTAPLDHKD 51KGLKSLTLEA SIPQNGTLTL SAQGAEKTFK AGGKDNSLNT GKLKNDKISR 101 FDFVQKIEVDGQTITLASGE FQIYKQDHSA VVALRIEKIN NPDKIDSLIN 151 QRSFLVSDLG GEHTAFNQLPDGKAEYHGKA FSSDDADGKL TYTIDFAAKQ 201 GHGKIEHLKT PEQNVELASA ELKADEKSHAVILGDTRYGG EEKGTYRLAL 251 FGDRAQEIAG SATVKIGEKV HEIGIADKQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2535>:

m741.seq 1 GTGAATCGAA CTGCCTTCTG CTGCCTTTCT CTGACCACTG CCCTGATTCT 51GACCGCCTGC AGCAGCGGAG GGGGTGGTGT CGCCGCCGAC ATCGGTGCGG 101 GGCTTGCCGATGCACTAACC GCACCGCTCG ACCATAAAGA CAAAGGTTTG 151 CAGTCTTTGA CGCTGGATCAGTCCGTCAGG AAAAACGAGA AACTGAAGCT 201 GGCGGCACAA GGTGCGGAAA AAACTTATGGAAACGGTGAC AGCCTCAATA 251 CGGGCAAATT GAAGAACGAC AAGGTCAGCC GTTTCGACTTTATCCGCCAA 301 ATCGAAGTGG ACGGGCAGCT CATTACCTTG GAGAGTGGAG AGTTCCAAGT351 ATACAAACAA AGCCATTCCG CCTTAACCGC CTTTCAGACC GAGCAAATAC 401AAGATTCGGA GCATTCCGGG AAGATGGTTG CGAAACGCCA GTTCAGAATC 451 GGCGACATAGCGGGCGAACA TACATCTTTT GACAAGCTTC CCGAAGGCGG 501 CAGGGCGACA TATCGCGGGACGGCGTTCGG TTCAGACGAT GCCGGCGGAA 551 AACTGACCTA CACCATAGAT TTCGCCGCCAAGCAGGGAAA CGGCAAAATC 601 GAACATTTGA AATCGCCAGA ACTCAATGTC GACCTGGCCGCCGCCGATAT 651 CAAGCCGGAT GGAAAACGCC ATGCCGTCAT CAGCGGTTCC GTCCTTTACA701 ACCAAGCCGA GAAAGGCAGT TACTCCCTCG GTATCTTTGG CGGAAAAGCC 751CAGGAAGTTG CCGGCAGCGC GGAAGTGAAA ACCGTAAACG GCATACGCCA 801 TATCGGCCTTGCCGCCAAGC AATAAThis corresponds to the amino acid sequence <SEQ ID 2536; ORF 741>:

m741.pep 1 VNRTAFCCLS LTTALILTAC SSGGGGVAAD IGAGLADALT APLDHKDKGL 51QSLTLDQSVR KNEKLKLAAQ GAEKTYGNGD SLNTGKLKND KVSRFDFIRQ 101 IEVDGQLITLESGEFQVYKQ SHSALTAFQT EQIQDSEHSG KMVAKRQFRI 151 GDIAGEHTSF DKLPEGGRATYRGTAFGSDD AGGKLTYTID FAAKQGNGKI 201 EHLKSPELNV DLAAADIKPD GKRHAVISGSVLYNQAEKGS YSLGIFGGKA 251 QEVAGSAEVK TVNGIRHIGL AAKQ* m741/g741 61.4%identity in 280 aa overlap          10           20        30        40        50 m741.pep  VNRTAFCCLSLTT---ALILTACSSGGGGVAADIGAGLADALTAPLDHKDKGLQSLTLDQ  ||||:|||||||:   :  |    :||||||||||:|||||||||||||||||:||||: g741  VNRTTFCCLSLTAGPDSDRLQQRRGGGGGVAADIGTGLADALTAPLDHKDKGLKSLTLEA          10        20        30        40        50        60   60        70           80        90       100       110 m741.pep  SVRKNEKLKLAAQGAEKTY---GNGDSLNTGKLKNDKVSRFDFIRQIEVDGQLITLESGE   |::|  | |:|||||||:   |: :|||||||||||:|||||:::|||||| ||| ||| g741  SIPQNGTLTLSAQGAEKTFKAGGKDNSLNTGKLKNDKISRFDFVQKIEVDGQTITLASGE          70        80        90       100       110       120     120       130       140       150       160       170 m741.pep  FQVYKQSHSALTAFQTEQIQDSEHSGKMVAKRQFRIGDIAGEHTSFDKLPEGGRATYRGT  ||:|||:|||::|:: |:|:: ::  ::: :|:| ::|::||||:|::||:| :| |:| g741  FQIYKQDHSAVVALRIEKINNPDKIDSLINQRSFLVSDLGGEHTAFNQLPDG-KAEYHGK         130       140       150       160       170     180       190       200       210       220       230 m741.pep  AFGSDDAGGKLTYTIDFAAKQGNGKIEHLKSPELNVDLAAADIKPDGKRHAVISGSVLYN  ||:|||| ||||||||||||||:|||||||:|| ||:||:|::| | | |||| |:: |: g741  AFSSDDADGKLTYTIDFAAKQGHGKIEHLKTPEQNVELASAELKADEKSHAVILGDTRYG180       190       200       210       220       230     240       250       260       270 m741.pep  QAEKGSYSLGIFGGKAQEVAGSAEVKTVNGIRHIGLAAKQX    |||:| |::|| :|||:|||| ||  : :::||:| ||| g741  GEEKGTYRLALFGDRAQEIAGSATVKIGEKVHEIGIADKQX240       250       260       270       280The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2537>:

a741.seq 1 GTGAACCGAA CTGCCTTCTG CTGCCTTTCT TTGACCGCCG CCCTGATTCT 51GACCGCCTGC AGCAGCGGAG GCGGCGGTGT CGCCGCCGAC ATCGGCGCGG 101 TGCTTGCCGATGCACTAACC GCACCGCTCG ACCATAAAGA CAAAAGTTTG 151 CAGTCTTTGA CGCTGGATCAGTCCGTCAGG AAAAACGAGA AACTGAAGCT 201 GGCGGCACAA GGTGCGGAAA AAACTTATGGAAACGGCGAC AGCCTCAATA 251 CGGGCAAATT GAAGAACGAC AAGGTCAGCC GCTTCGACTTTATCCGTCAA 301 ATCGAAGTGG ACGGGCAGCT CATTACCTTG GAGAGCGGAG AGTTCCAAGT351 GTACAAACAA AGCCATTCCG CCTTAACCGC CCTTCAGACC GAGCAAGTAC 401AAGATTCGGA GCATTCAGGG AAGATGGTTG CGAAACGCCA GTTCAGAATC 451 GGCGATATAGCGGGTGAACA TACATCTTTT GACAAGCTTC CCGAAGGCGG 501 CAGGGCGACA TATCGCGGGACGGCATTCGG TTCAGACGAT GCCAGTGGAA 551 AACTGACCTA CACCATAGAT TTCGCCGCCAAGCAGGGACA CGGCAAAATC 601 GAACATTTGA AATCGCCAGA ACTCAATGTT GACCTGGCCGCCTCCGATAT 651 CAAGCCGGAT AAAAAACGCC ATGCCGTCAT CAGCGGTTCC GTCCTTTACA701 ACCAAGCCGA GAAAGGCAGT TACTCTCTAG GCATCTTTGG CGGGCAAGCC 751CAGGAAGTTG CCGGCAGCGC AGAAGTGGAA ACCGCAAACG GCATACGCCA 801 TATCGGTCTTGCCGCCAAGC AGTAAThis corresponds to the amino acid sequence <SEQ ID 2538; ORF 741.a>:

a741.pep 1 VNRTAFCCLS LTAALILTAC SSGGGGVAAD IGAVLADALT APLDHKDKSL 51QSLTLDQSVR KNEKLKLAAQ GAEKTYGNGD SLNTGKLKND KVSRFDFIRQ 101 IEVDGQLITLESGEFQVYKQ SHSALTALQT EQVQDSEHSG KMVAKRQFRI 151 GDIAGEHTSF DKLPEGGRATYRGTAFGSDD ASGKLTYTID FAAKQGHGKI 201 EHLKSPELNV DLAASDIKPD KKRHAVISGSVLYNQAEKGS YSLGIFGGQA 251 QEVAGSAEVE TANGIRHIGL AAKQ* a741/m741 95.6%identity in 274 aa overlap        10        20        30        40        50        60 a741.pepVNRTAFCCLSLTAALILTACSSGGGGVAADIGAVLADALTAPLDHKDKSLQSLTLDQSVR||||||||||||:|||||||||||||||||||| ||||||||||||||:||||||||||| m741VNRTAFCCLSLTTALILTACSSGGGGVAADIGAGLADALTAPLDHKDKGLQSLTLDQSVR        10        20        30        40        50        60        70        80        90       100       110       120 a741.pepKNEKLKLAAQGAEKTYGNGDSLNTGKLKNDKVSRFDFIRQIEVDGQLITLESGEFQVYKQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m741KNEKLKLAAQGAEKTYGNGDSLNTGKLKNDKVSRFDFIRQIEVDGQLITLESGEFQVYKQ        70        80        90       100       110       120       130       140       150       160       170       180 a741.pepSHSALTALQTEQVQDSEHSGKMVAKRQFRIGDIAGEHTSFDKLPEGGRATYRGTAFGSDD|||||||:||||:||||||||||||||||||||||||||||||||||||||||||||||| m741SHSALTAFQTEQIQDSEHSGKMVAKRQFRIGDIAGEHTSFDKLPEGGRATYRGTAFGSDD       130       140       150       160       170       180       190       200       210       220       230       240 a741.pepASGKLTYTIDFAAKQGHGKIEHLKSPELNVDLAASDIKPDKKRHAVISGSVLYNQAEKGS|:||||||||||||||:|||||||||||||||||:||||| ||||||||||||||||||| m741AGGKLTYTIDFAAKQGNGKIEHLKSPELNVDLAAADIKPDGKRHAVISGSVLYNQAEKGS       190       200       210       220       230       240       250       260       270 a741.pepYSLGIFGGQAQEVAGSAEVETANGIRHIGLAAKQX ||||||||:||||||||||:|:|||||||||||||m741 YSLGIFGGKAQEVAGSAEVKTVNGIRHIGLAAKQX        250       260       270

g742.seq not found yet

g742.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2539>:

m742.seq 1 ATGGTTTACG GCATTGCCGA AGCCGATGCG GGCGACAGCA GTGTGCTTAC 51TTTGGGCGGC ATGTATCAGA AGAGTAGGGA GGTTCCTGAT TTTTCGGGCA 101 TTATTTTGCCCTGTGAAAAT CAGAAAACTG CCCCGTTCAG TTCAACGCCT 151 GCCTGCAACC GGCCTTTGCAACTGCCGCGC AACACTTATT TGGGGGAGGA 201 TTGGTCGCGG TTAAGTGCCG ACAAATACAACCTTTTCTCA GGATTCAAAC 251 ATGTGTTTGA CAACGGTTGG CAGCTCAATG CCGAAGTGTCTTATACCAAG 301 AATGAATCCG ATGCGAAGGT GGGGCAGTTT TTTCTGAAAA ACGAATATGC351 GGCGGGTTTG TCGGGTGAGG ATGCGGTAGG CTTTTTGACT GAAAAAAACG 401AAGTCATCCC GTTCGAGCCG AAAGATAAGG CATTGGAGAA ACTGAAAGCA 451 TATCGTGATGAAACCGCCAA GGAATACCGG GAGCGCAAAG ACGATTTTGT 501 TAAAAACCGT TTCGATAATACTGCTTTCGA ACAGTATCGC AGCCGCCGTG 551 CCGCAGAACG CAAAGCCGGT TTTGACAAGTGTATGAGTGA CCCTTTCGCG 601 CTGGACTTTA TCTGTCAAGG TTCTTGGGGG GATCCGGGCGTTGATGCCGA 651 CAAGGCGGAA TTTGTCGATA AAGCCCTTGC GAAGGAGGGC ATCTTTAATA701 ATGCGGCACA ACGTTTTCCA AACAGCCTGT ATGACTCTTC CTTTAATCGG 751AAGGCTACCG CCAACCGACG ATACAGTTAT ATGCCGTTGC GGCATACCAA 801 AGACGACCGCCAATGGGGAA TTAAACTTGA CCTGACCGGC ACATATGGGC 851 TGTTCGGGCG GGAGCATGATTTCTTTGTCG GCTATGCCTA CGGTGATGAA 901 AAGATACGTT CGGAATATCT AGAAATCTACGAACGCCGCT ACAGAGTACG 951 TCCGAATACG GGGGCAACGC ACGGCGTGTA TGCGGGAAGTTGTCAGGAGG 1001 AGCCGGACGG CGATTTGTCG TCTCCTTTGG TCAGGGGGCA TAAAGAACCC1051 GATTGGCAGG CGTACGATGA AAAAGGCAAC CGTACCGTTT ATGCCGAAGA 1101ATGCAGGAAC GCCAAGAAAA TAAAAACCGA GCCCAAGCTC GATGCCGAAG 1151 GCAAGCAGGTGTATTACTAT GACGAATACA GCGGCAGCCG GACACCGGTA 1201 TATGTCGATG TATATGAGCTGGACGAAAAA GGCAACAAGA TTCAGGAGAC 1251 CAATCCCGAC GGCACGCCTG CCTTTACCGGTTTTTCCGGT ACGGTGCCGG 1301 TTTGGAAAAC CGTCAAAGTG GCAGACGACC ATGTTCCTGCGCTGTATAAC 1351 TACGCCAAAT ACCTCAACAC CAACAAAACC CATTCGCTGA CTGCCAGCAC1401 GCGTTTCAAC GTAACCGGCC GACTGCACCT TTTGGGCGGG CTGCACTACA 1451CGCGCTATGA GACTTCGCAA ACCAAAGATA TGCCTGTCCG CTATGGGCAG 1501 CCGGCAAGCGATTTTCAGAC GGCATCGAGC ATTAGGGCGG ATCAGGACCA 1551 TTACACGGCC AAGATGCAAGGTCATAAATT GACGCCCTAT GCAGGCATTA 1601 CCTATGACTT GACACCGCAA CAGAGTATTTACGGAAGTTA TACCAAAATC 1651 TTCAAACAGC AGGATAATGT CGATGTCAGT GCCAAAACCGTTTTACCGCC 1701 TTTGGTCGGC ACAAACTATG AGGTAGGCTG GAAAGGCGCG TTCTTGCAAG1751 GACGGCTGAA TGCTTCGTTC GCATTGTTTT ACCTCGAACA GAAAAACCGC 1801ACGGTCGTCG ATTTCGGCTA TGTTCCCGGA GCAGGCGGCA AGCAGGGGTC 1851 GTTCCAAACCGTTGCCAAAC CGATAGGCAA AGTGGTCAGC AGGGGTGCGG 1901 AATTCGAGTT GTCGGGTGAGTTGAACGAAG ATTGGAAAGT CTTTGCGGGT 1951 TACACCTACA ACAAGAGCCG CTACAAAAACGCCGCCGAAG TCAACGCCGA 2001 ACGCCTTGCC AAAAATTCCA GTGCAGACCC GTACAACTTCAGCAATTTCA 2051 CACCCGTGCA CATATTCCGT TTCGGAACGA GCTTCCATAT ACCGAATACG2101 GGGCTGACCG TCGGCGGCGG CGTGTCCGCA CAAAGCGGCA CAAGCAGTCT 2151GTATAACATC AGGCAGGGCG GCTACGGGCT GATAGACGGT TTCGTCCGTT 2201 ACGAATTGGGCAAACACGCC AAATTGAGCC TCATCGGTAC GAACTTAAAC 2251 GGACGCACTT ATTTTGAGAACAACTACAAC CGTACGCGCG GCGCAAACAA 2301 CTTCTACGGA GAGCCGCGCA CTGTCAGCATGAAACTGGAT TGGCAGTTTT 2351 AAThis corresponds to the amino acid sequence <SEQ ID 2540; ORF 742>:

m742.pep 1 MVYGIAEADA GDSSVLTLGG MYQKSREVPD FSGIILPCEN QKTAPFSSTP 51ACNRPLQLPR NTYLGEDWSR LSADKYNLFS GFKHVFDNGW QLNAEVSYTK 101 NESDAKVGQFFLKNEYAAGL SGEDAVGFLT EKNEVIPFEP KDKALEKLKA 151 YRDETAKEYR ERKDDFVKNRFDNTAFEQYR SRRAAERKAG FDKCMSDPFA 201 LDFICQGSWG DPGVDADKAE FVDKALAKEGIFNNAAQRFP NSLYDSSFNR 251 KATANRRYSY MPLRHTKDDR QWGIKLDLTG TYGLFGREHDFFVGYAYGDE 301 KIRSEYLEIY ERRYRVRPNT GATHGVYAGS CQEEPDGDLS SPLVRGHKEP351 DWQAYDEKGN RTVYAEECRN AKKIKTEPKL DAEGKQVYYY DEYSGSRTPV 401YVDVYELDEK GNKIQETNPD GTPAFTGFSG TVPVWKTVKV ADDHVPALYN 451 YAKYLNTNKTHSLTASTRFN VTGRLHLLGG LHYTRYETSQ TKDMPVRYGQ 501 PASDFQTASS IRADQDHYTAKMQGHKLTPY AGITYDLTPQ QSIYGSYTKI 551 FKQQDNVDVS AKTVLPPLVG TNYEVGWKGAFLQGRLNASF ALFYLEQKNR 601 TVVDFGYVPG AGGKQGSFQT VAKPIGKVVS RGAEFELSGELNEDWKVFAG 651 YTYNKSRYKN AAEVNAERLA KNSSADPYNF SNFTPVHIFR FGTSFHIPNT701 GLTVGGGVSA QSGTSSLYNI RQGGYGLIDG FVRYELGKHA KLSLIGTNLN 751GRTYFENNYN RTRGANNFYG EPRTVSMKLD WQF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2541>:

a742.seq 1 ATGGTTTACG GCATTGCCGA AGCCGATGCG GGCGACAGCA GTGTGCTTAC 51TTTGGGCGGC ATGTATCAGA AGAGTAGGGA GGTTCCTGAT TTTTCGGGCA 101 TTATTTTGTCCTGTGAAAAT CAGAAAACTG CCCCGTTCAG TTCAACGCCT 151 GCCTGCAACC GGCCTTTGCAACTGCCGCGC AACACTTATT TGGGGGAGGA 201 TTGGTCGCGG TTGAGTGCTG ACAAATACAACCTTTTCTCA GGTTTCAAAC 251 ATGTGTTTGA CAACGGTTGG CAGCTCAATG CCGAAGTGTCTTATACCAAG 301 AATGAATCCG ATGCGAAGGT GGGGCAGTTT TTTCTGAAAA ACGAACATGC351 GGCGGGTTTG TCAGATGAGG ATGCGGTAGG CTTTTTGACC GAAAAAAACG 401AAGTCATCCC GTTCGAGCCG AAAGATAAGG CATTGGAGAA ACTGAAAGCA 451 TATCGTGACGAAACCGCCAA GGAATACCGT GAGCGCAAAG ACGATTTTGT 501 TAAAAACCGT TTCGATAATACTGCTTTCGA GCAGTACCGC AGCCGCCGTG 551 CCGCAGAACG CAAAGCCGGT TTTGACGAGTGTATGAGTGC CCCTTTTGCG 601 CTGGACTTTA TCTGTCAAGG TTCTTGGGGG GATCCGGGTGTTGATGCCGA 651 CAAGTCGGAA TTTGTCGATA AAGCCCTTGC GAAGGAAGGC ATCTTTAATA701 ATGCGGCACA ACGTTTTCCA AACAGCCTGT ATGACTCTTC CTTTAATCGG 751AAGGCTACCG CCAACCGACG ATACAGTTAT ATGCCGTTGC GGCATACCAA 801 AGACGACCGCCAATGGGGAA TTAAACTTGA CCTGACCGGC ACATATGGGC 851 TGTTCGGGCG GGAGCATGATTTCTTTGTCG GCTATGCCTA CGGCGATGAA 901 AAGATACGTT CCGAATATCT GGAAATCTACGAACGCCGCC ACAGAGTACG 951 TCCGAATACA GGGGCAACGC ACGGCGTGTA TGCGGGAAGTTGTCAGGGGG 1001 AGCCGGACGG TGATTTGTCT TCTCCTTTGG TCAGGGGGCA TAAAGAACCC1051 GATTGGCAGG CGTACGATGA AAAAGGCAAC CGTACCGTTT ATGCCGAAGA 1101ATGCAGGAAT GCCAAGAAAA TAAAAACCGA GCCCAAGCTC GATGCCGAAG 1151 GCAAGCAGGTGTATTACTAT GACGAATACA GCGGCAGCCG GACGCCAGTA 1201 TATGTCGATG TATATGAACTGGATGAAAAA GGCAATAAGA TTCAGGAGAC 1251 CAATCCCGAC GGCACGCCTG CCTTTACCGGTTTTTCCGGT ACGGTGCCGG 1301 TTTGGAAAAC CGTCAAAGTG GCCGACGACC ATGTTCCTGCGCTGTATAAC 1351 TACGCCAAAT ACCTCAACAC CAACAAAACC CATTCGCTGA CTGCCGGCAC1401 GCGTTTCAAC GTAACCGGCC GACTGCATCT TTTGGGCGGG CTGCACTACA 1451CGCGCTATGA AACCTCGCAA ACCAAAGATA TGCCTGTCCG CTATGGGCAG 1501 CCGGCAAGCGATTTTCAGAC GGCATCGAGC ATTAAGGCGG ATCAGGACCA 1551 TTATACGGCC AAGATGCAAGGTCATAAATT GACGCCCTAT GCAGGCATTA 1601 CCTATGATTT GACACCGCAA CAGAGTATTTACGGAAGTTA TACCAAAATC 1651 TTCAAACAGC AGGATAATGT CGATGTCAGT GCCAAAACCGTTTTACCGCC 1701 TTTGGTCGGC ACAAACTATG AGGTAGGCTG GAAAGGCGCG TTCTTGCAAG1751 GACGGCTGAA TGCTTCGTTC GCATTGTTTT ACCTCGAACA GAAAAACCGC 1801ACGGTCGTCG ATTTTGGCTA TGTTCCCGGA GCAGGCGGCA AGCAGGGGTC 1851 GTTCCAAACCGTTGCCAAAC CGATAGGCAA AGTGGTCAGC AGGGGTGCGG 1901 AATTCGAGTT GTCGGGTGAGTTGAACGAAG ATTGGAAAGT CTTTGCGGGT 1951 TACACCTACA ACAAGAGCCG CTACAAAAACGCCGCCGAAG TCAACGCCGA 2001 ACGCCTCGCC AAAAACACAG GCGCAGACCC GTACAACTTCAGCAATTTCA 2051 CACCCGTGCA CATATTCCGT TTCGGAACGA GCTTCCATAT ACCGAATACG2101 GGGCTGACCG TCGGCGGCGG CGTGTCCGCA CAAAGCGGCA CAAGCAGTCT 2151GTATAACATC AGGCAGGGCG GCTACGGGCT GATAGACGGT TTCGTCCGTT 2201 ACGAATTGGGCAAACACGCT AAATTGAGCC TCATCGGTAC GAACTTAAAC 2251 GGACGCACTT ATTTTGAGAACAACTACAAC CGTACGCGCG GCGCAAACAA 2301 CTTCTATGGA GAGCCGCGCA CTGTCAGCATGAAACTGGAT TGGCAGTTTT 2351 AAThis corresponds to the amino acid sequence <SEQ ID 2542; ORF 742.a>:

a742.pep 1 MVYGIAEADA GDSSVLTLGG MYQKSREVPD FSGIILSCEN QKTAPFSSTP 51ACNRPLQLPR NTYLGEDWSR LSADKYNLFS GFKHVFDNGW QLNAEVSYTK 101 NESDAKVGQFFLKNEHAAGL SDEDAVGFLT EKNEVIPFEP KDKALEKLKA 151 YRDETAKEYR ERKDDFVKNRFDNTAFEQYR SRRAAERKAG FDECMSAPFA 201 LDFICQGSWG DPGVDADKSE FVDKALAKEGIFNNAAQRFP NSLYDSSFNR 251 KATANRRYSY MPLRHTKDDR QWGIKLDLTG TYGLFGREHDFFVGYAYGDE 301 KIRSEYLEIY ERRHRVRPNT GATHGVYAGS CQGEPDGDLS SPLVRGHKEP351 DWQAYDEKGN RTVYAEECRN AKKIKTEPKL DAEGKQVYYY DEYSGSRTPV 401YVDVYELDEK GNKIQETNPD GTPAFTGFSG TVPVWKTVKV ADDHVPALYN 451 YAKYLNTNKTHSLTAGTRFN VTGRLHLLGG LHYTRYETSQ TKDMPVRYGQ 501 PASDFQTASS IKADQDHYTAKMQGHKLTPY AGITYDLTPQ QSIYGSYTKI 551 FKQQDNVDVS AKTVLPPLVG TNYEVGWKGAFLQGRLNASF ALFYLEQKNR 601 TVVDFGYVPG AGGKQGSFQT VAKPIGKVVS RGAEFELSGELNEDWKVFAG 651 YTYNKSRYKN AAEVNAERLA KNTGADPYNF SNFTPVHIFR FGTSFHIPNT701 GLTVGGGVSA QSGTSSLYNI RQGGYGLIDG FVRYELGKHA KLSLIGTNLN 751GRTYFENNYN RTRGANNFYG EPRTVSMKLD WQF* a742/m742 98.5% identity in 783 aaoverlap         10        20        30        40        50        60a742.pep MVYGIAEADAGDSSVLTLGGMYQKSREVPDFSGIILSCENQKTAPFSSTPACNRPLQLPR|||||||||||||||||||||||||||||||||||| ||||||||||||||||||||||| m742MVYGIAEADAGDSSVLTLGGMYQKSREVPDFSGIILPCENQKTAPFSSTPACNRPLQLPR        10        20        30        40        50        60        70        80        90       100       110       120 a742.pepNTYLGEDWSRLSADKYNLFSGFKHVFDNGWQLNAEVSYTKNESDAKVGQFFLKNEHAAGL|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||| m742NTYLGEDWSRLSADKYNLFSGFKHVFDNGWQLNAEVSYTKNESDAKVGQFFLKNEYAAGL        70        80        90       100       110       120       130       140       150       160       170       180 a742.pepSDEDAVGFLTEKNEVIPFEPKDKALEKLKAYRDETAKEYRERKDDFVKNRFDNTAFEQYR| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m742SGEDAVGFLTEKNEVIPFEPKDKALEKLKAYRDETAKEYRERKDDFVKNRFDNTAFEQYR       130       140       150       160       170       180       190       200       210       220       230       240 a742.pepSRRAAERKAGFDECMSAPFALDFICQGSWGDPGVDADKSEFVDKALAKEGIFNNAAQRFP||||||||||||:||| |||||||||||||||||||||:||||||||||||||||||||| m742SRRAAERKAGFDKCMSDPFALDFICQGSWGDPGVDADKAEFVDKALAKEGIFNNAAQRFP       190       200       210       220       230       240       250       260       270       280       290       300 a742.pepNSLYDSSFNRKATANRRYSYMPLRHTKDDRQWGIKLDLTGTYGLFGREHDFFVGYAYGDE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m742NSLYDSSFNRKATANRRYSYMPLRHTKDDRQWGIKLDLTGTYGLFGREHDFFVGYAYGDE       250       260       270       280       290       300       310       320       330       340       350       360 a742.pepKIRSEYLEIYERRHRVRPNTGATHGVYAGSCQGEPDGDLSSPLVRGHKEPDWQAYDEKGN|||||||||||||:|||||||||||||||||| ||||||||||||||||||||||||||| m742KIRSEYLEIYERRYRVRPNTGATHGVYAGSCQEEPDGDLSSPLVRGHKEPDWQAYDEKGN       310       320       330       340       350       360       370       380       390       400       410       420 a742.pepRTVYAEECRNAKKIKTEPKLDAEGKQVYYYDEYSGSRTPVYVDVYELDEKGNKIQETNPD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m742RTVYAEECRNAKKIKTEPKLDAEGKQVYYYDEYSGSRTPVYVDVYELDEKGNKIQETNPD       370       380       390       400       410       420       430       440       450       460       470       480 a742.pepGTPAFTGFSGTVPVWKTVKVADDHVPALYNYAKYLNTNKTHSLTAGTRFNVTGRLHLLGG|||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||| m742GTPAFTGFSGTVPVWKTVKVADDHVPALYNYAKYLNTNKTHSLTASTRFNVTGRLHLLGG       430       440       450       460       470       480       490       500       510       520       530       540 a742.pepLHYTRYETSQTKDMPVRYGQPASDFQTASSIKADQDHYTAKMQGHKLTPYAGITYDLTPQ|||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||| m742LHYTRYETSQTKDMPVRYGQPASDFQTASSIRADQDHYTAKMQGHKLTPYAGITYDLTPQ       490       500       510       520       530       540       550       560       570       580       590       600 a742.pepQSIYGSYTKIFKQQDNVDVSAKTVLPPLVGTNYEVGWKGAFLQGRLNASFALFYLEQKNR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m742QSIYGSYTKIFKQQDNVDVSAKTVLPPLVGTNYEVGWKGAFLQGRLNASFALFYLEQKNR       550       560       570       580       590       600       610       620       630       640       650       660 a742.pepTVVDFGYVPGAGGKQGSFQTVAKPIGKVVSRGAEFELSGELNEDWKVFAGYTYNKSRYKN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m742TVVDFGYVPGAGGKQGSFQTVAKPIGKVVSRGAEFELSGELNEDWKVFAGYTYNKSRYKN       610       620       630       640       650       660       670       680       690       700       710       720 a742.pepAAEVNAERLAKNTGADPYNFSNFTPVHIFRFGTSFHIPNTGLTVGGGVSAQSGTSSLYNI||||||||||||::|||||||||||||||||||||||||||||||||||||||||||||| m742AAEVNAERLAKNSSADPYNFSNFTPVHIFRFGTSFHIPNTGLTVGGGVSAQSGTSSLYNI       670       680       690       700       710       720       730       740       750       760       770       780 a742.pepRQGGYGLIDGFVRYELGKHAKLSLIGTNLNGRTYFENNYNRTRGANNFYGEPRTVSMKLD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m742RQGGYGLIDGFVRYELGKHAKLSLIGTNLNGRTYFENNYNRTRGANNFYGEPRTVSMKLD       730       740       750       760       770       780 a742.pepWQFX |||| m742 WQFX a742/p25184 sp|P25184|PUPA_PSEPU FERRIC-PSEUDOBACTIN358 RECEPTOR PRECURSOR >gi|949231|pir||S15169 ferric-pseudobactinreceptor precursor - Pseudomonas putida >gi|45723 (X56605) pseudobactinuptake protein [Pseudomonas putida]Length = 819 Score = 152 bits (381),Expect = 6e−36 Identities = 110/356 (30%), Positives = 170/356 (46%),Gaps = 55/356 (15%) Query: 436KTVKVADDHV-PALYNYAKYLNTNKTHSLTAGTRFNVTGRLHLLGGLHYTRYETSQTKDM 494 +TK  DD + P +    +Y  +N+       +RFN+T  LHL+ G   + Y Sbjct: 511QTPKPGDDEIIPGI----QYNISNRQSGYFVASRFNLTDDLHLILGARASNYRFDYAL-- 564 Query:495 PVRYGQPASDFQTASSIKADQDHYTAKMQGHKLTPYAGITYDLTPQQSIYGSYTKIFKQQ 554   RG   + ++               ++   +TPYAGI YDLT +QS+Y SYT IFK Q Sbjct: 565-WRIGNEPAPYKM--------------VERGVVTPYAGIVYDLTNEQSVYASYTDIFKPQ 609 Query:555 DNVDVSAKTVLPPLVGTNYEVGWKGAFLQGRLNASFALFYLEQKNRTVVDFGYVPGAGGK 614+NVD++ K  L P VG NYE+GWKG FL+GRLNA+ AL+ +++ N        VP +GG Sbjct: 610NNVDITGKP-LDPEVGKNYELGWKGEFLEGRLNANIALYMVKRDNLAESTNEVVPDSGGL 668 Query:615 QGSFQTVAKPIGKVVSRGAEFELSGELNEDWKVFAGYTYNKSRYKNAAEVNAERLAKNTG 674  S     + +    ++G + ELSGE+   W VF GY++ ++ Sbjct: 669IAS-----RAVDGAETKGVDVELSGEVLPGWNVFTGYSHTRTE----------------D 707 Query:675 ADPYNFSNFTPVHIFRFGTSFHIPN--TGLTVGGGVSAQSGTS---SLYN--IRQGGYGL 727AD    +   P+  FRF  ++ +P     LT+GGGV+  S ++   + YN  + Q  Y + Sbjct: 708ADGKRLTPQLPMDTFRFWNTYRLPGEWEKLTLGGGVNWNSKSTLNFARYNSHVTQDDYFV 767 Query:728 IDGFVRYELGKHAKLSLIGTNLNGRTYFENNYNRTRGANNFYGEPRTVSMKLDWQF 783      RY+ +    +L   N+  + Y    Y    G+   YG PR  ++ L + F Sbjct: 768TSLMARYRINESLAATLNVNNIFDKKY----YAGMAGSYGHYGAPRNATVTLRYDF 819 g743.seqnot found yet g743.pep not found yetThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2543>:

m743.seq 1 ATGAATCAAA ATCATTTTTC ACTTAAAATT CTGACCGTTA TGCTGTTATC 51GGCTTACGGT GGTTCTTTTG CAGACGGTGT TGTGCCTGTT TCAGACGGCA 101 ATACCGTCAGTCTGGATACG GTCAATGTAC GCGGCTCTCA TGCTTTGTTG 151 GGCAAGACCG AAAAGACCCGTTCTTATACG ATAGATCGGA TGTCCACCGC 201 CACAGGTATG AGGATTGCGG GCAAGGATACGCCGCAGTCG GTCAGCGTCA 251 TCACGCGCAG CCGCCTTGAC GATAAGGCGG TGCATACGCTTGAAGAGGCA 301 ATGAAAAACA CGACGGGTGT CAACGTTGTG CGCGATTCAG GCTTGCAGAC351 GCGGTTTTTG TCACGCGGTT TCTATATTGA TCAGATTGGT GAAGACGGTA 401TGACCGTCAA TGTTGCAGGC CGTTCGGGAT ATACGGCGAA AATCGACGTG 451 TCTCCGAGTACCGATTTGGC GGTTTATGAC CATATTGAAG TTGTACGGGG 501 TGCAACGGGG TTGACCCAATCCAATTCAGA GCCGGGAGGA ACCGTCAATT 551 TGATCCGTAA GTGAThis corresponds to the amino acid sequence <SEQ ID 2544; ORF 743>:

m743.pep 1 MNQNHFSLKI LTVMLLSAYG GSFADGVVPV SDGNTVSLDT VNVRGSHALL 51GKTEKTRSYT IDRMSTATGM RIAGKDTPQS VSVITRSRLD DKAVHTLEEA 101 MKNTTGVNVVRDSGLQTRFL SRGFYIDQIG EDGMTVNVAG RSGYTAKIDV 151 SPSTDLAVYD HIEVVRGATGLTQSNSEPGG TVNLIRK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2545>:

a743.seq 1 ATGAATCAAA ATCATTTTTC ACTTAAAATT CTGACCGTTA TGCTGTTATC 51GGCTTACGGT GGTTCTTTTG CAGACGGTGT TGTGCCTGTT TCAGACGGCA 101 ATACCGTCAGTTTGGATACG GTCAATGTAC GCGGCTCTCA TGCTCTGTCG 151 GGCAAGACCG AGAAGACCCGTTCTTATACG ATAGATCGGA TGTCCACCGC 201 CACAGGTATG AGGATTGCGG GCAAGGATACGCCGCAGTCG GTCAGCGTCA 251 TCACGCGCAG CCGCCTTGAC GATAAGGCGG TGCATACGCTTGAAGAGGCA 301 ATGAAAAACA CGACGGGTGT CAACGTTGTG CGCGATTCAG GCTTGCAGAC351 GCGGTTTTTG TCACGCGGTT TCTATATTGA TCAGATTGGT GAAGACGGTA 401TTACCGTCAA TGTTGCAGGC CGTTCGGGAT ATACGGCGAA AATCGACGTG 451 TCTCCGAGTACCGATTTGGC GGTTTATGAC CATATTGAAG TTGTACGGGG 501 TGCAACGGGG TTGACCCAATCCAATTCAGA GCCGGGTGGA ACCGTCAATT 551 TGATCCGTAA GCGAThis corresponds to the amino acid sequence <SEQ ID 2546; ORF 743.a>:

a743.pep 1 MNQNHFSLKI LTVMLLSAYG GSFADGVVPV SDGNTVSLDT VNVRGSHALS 51GKTEKTRSYT IDRMSTATGM RIAGKDTPQS VSVITRSRLD DKAVHTLEEA 101 MKNTTGVNVVRDSGLQTRFL SRGFYIDQIG EDGITVNVAG RSGYTAKIDV 151 SPSTDLAVYD HIEVVRGATGLTQSNSEPGG TVNLIRKR a743/m743 98.9% identity in 187 aa overlap        10        20        30        40        50        60 a743.pepMNQNHFSLKILTVMLLSAYGGSFADGVVPVSDGNTVSLDTVNVRGSHALSGKTEKTRSYT||||||||||||||||||||||||||||||||||||||||||||||||| |||||||||| m743MNQNHFSLKILTVMLLSAYGGSFADGVVPVSDGNTVSLDTVNVRGSHALLGKTEKTRSYT        10        20        30        40        50        60        70        80        90       100       110       120 a743.pepIDRMSTATGMRIAGKDTPQSVSVITRSRLDDKAVHTLEEAMKNTTGVNVVRDSGLQTRFL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m743IDRMSTATGMRIAGKDTPQSVSVITRSRLDDKAVHTLEEAMKNTTGVNVVRDSGLQTRFL        70        80        90       100       110       120       130       140       150       160       170       180 a743.pepSRGFYIDQIGEDGITVNVAGRSGYTAKIDVSPSTDLAVYDHIEVVRGATGLTQSNSEPGG|||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||| m743SRGFYIDQIGEDGMTVNVAGRSGYTAKIDVSPSTDLAVYDHIEVVRGATGLTQSNSEPGG       130       140       150       160       170       180 a743.pepTVNLIRKR ||||||| m743 TVNLIRKX

g744.seq not found yet

g744.pep not found yetThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2547>:

m744.seq 1 ATGAAACCGT TAAAAACATT AGAATTTGGA TTTGTGGATG CTGCAAACTA 51CAGAAGAAGA GAAAATAAAG ATTTATTTAA CCGAATATTT GTAAAAGGAG 101 AATATTTGGATGAATTATGT GAACCAAATA TTTCGTTTTT AATCGGAGAA 151 AAGGGAACTG GAAAGACAGCATATGCTGTT TATTTAACTA ATAACTTCTA 201 TAAAAACATA CATGCCACTA CTAAGTTTGTTCGTGAAACC GATTATTCAA 251 AATTTATTCA GCTAAAGAAA GCAAGACACT TAACTGTTTCAGATTTTACA 301 AGTATTTGGA AAGTCATTTT ATATCTGTTG ATATCAAATC AAATCAAATG351 TAAAGAAAAC GGAATATTAT CTTCAATATT TAATAAATTT AAAGCCTTAG 401ATGAGGCTAT AAATGAATAT TATTATGGCG CTTTTGATCC GGAAATTGTA 451 CAAGCAATAACTTTAATAGA AAATTCAAAA GAAGCTGCGG AAATGATTTT 501 TGGAAAATTT GTTAAACTAGGTGAAGAGGA ATCCCAACAA ATAACTTTTA 551 CAGAAAGTAA ATTCCAAGCA AATTTAGGTTTTATTGAAAG AAAATTTAAA 601 GATGCTTTAT CTCAGTTAAA GCTAAAAGAT AATCATATTTTGTTTATTGA 651 TGGGATAGAT ATTAGACCAT CACAGATTCC ATTTGATGAA TATCATGAGT701 GTGTAAAAGG TCTTGCTAAC GCCATATGGA TGTTAAATAA TGATATCTTC 751CCTTCCATTA AAGATAGTAA GGGAAGGATG AGAGTTGTGT TATTGATTAG 801 ACCTGATATCTTTGATTCAT TAGGTTTACA AAATCAAAAT ACCAAACTTC 851 AAGATAATTC AGTATTTTTAGACTGGAGGA CGGATTATAA ATCTTATAGA 901 AGTTCAAAGA TTTTTGGCGT TTTTGATCATCTTTTGAGAA CCCAGCAAGA 951 AAAACAAGAT AGTTTAGAAA AAGGCAACTC ATGGGATTATTATTTTCCAT 1001 GGAATGCTCC TAATTTACAT GATGAGTATA AAAATTTAAC TTCATTTATT1051 AGCTTCCTAA GAAAATCGTA TTATCGACCT CGCGATATTC TTCAGATGCT 1101TACTTTGCTA CAAAAAAATA AGAAAAGTAA GGAAGATTAT GTCGTAGCAG 1151 AAGATTTTGATAATACTTCT TTTCAAAGAG AATACTCGAT ATATTTACTT 1201 GGTGAAATCA AAGATCATCTTTTGTTTTAT TATAGTCAAA GTGATTATCA 1251 AAATTTCCTG AAATTTTTTG AATTTTTAAACGGGAAAGAT AGATTTAAAT 1301 ATAGTGATTT TTTAAAAGCA TTTGAACGTT TGAAAAAGCACTTACAAACA 1351 ACATCAGTGG AAATACCTAA ATTTATGAGT ACTGCTAATG AGTTTTTGCA1401 ATTTTTATTT GACTTGAATG TTATTGCTTA TTTAGATAAC CCAGAAGATG 1451AAACGAAACC ATATATCCAT TGGTGCTTTA AAGATAGAAA TTATGCAAAT 1501 ATTTCTCCTAAAATAAAAAC TGAAACTGAA TATTTAATAT TTTCAGGATT 1551 ATCAAAAGCC CTTGATGTTGGTACTCCATT TAAGAACAAA CAGTAAThis corresponds to the amino acid sequence <SEQ ID 2548; ORF 744>:

m744.pep 1 MKPLKTLEFG FVDAANYRRR ENKDLFNRIF VKGEYLDELC EPNISFLIGE 51KGTGKTAYAV YLTNNFYKNI HATTKFVRET DYSKFIQLKK ARHLTVSDFT 101 SIWKVILYLLISNQIKCKEN GILSSIFNKF KALDEAINEY YYGAFDPEIV 151 QAITLIENSK EAAEMIFGKFVKLGEEESQQ ITFTESKFQA NLGFIERKFK 201 DALSQLKLKD NHILFIDGID IRPSQIPFDEYHECVKGLAN AIWMLNNDIF 251 PSIKDSKGRM RVVLLIRPDI FDSLGLQNQN TKLQDNSVFLDWRTDYKSYR 301 SSKIFGVFDH LLRTQQEKQD SLEKGNSWDY YFPWNAPNLH DEYKNLTSFI351 SFLRKSYYRP RDILQMLTLL QKNKKSKEDY VVAEDFDNTS FQREYSIYLL 401GEIKDHLLFY YSQSDYQNFL KFFEFLNGKD RFKYSDFLKA FERLKKHLQT 451 TSVEIPKFMSTANEFLQFLF DLNVIAYLDN PEDETKPYIH WCFKDRNYAN 501 ISPKIKTETE YLIFSGLSKALDVGTPFKNK Q*

g745.seq not found yet

g745.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2549>:

m745.seq 1 ATGTTTTGGC AACTGACCGT TGTTTCAGTA ACCGCCGTCA TTGCACTGGG 51GACAATATTC ATCAATAAGA AAACTTCAAA GCAAAAGGCG ACATTAGATG 101 TTATTTTGAATGATTACCAA GATGCACAAT TTGTAGAAGC CGACAATCAT 151 ATTTCGCCTT ATATTCGCGGCACGGCAGTT GACGACAACA ACGCGCGGAT 201 CGACCTGTAT GAAATTTATC AAAATAAGGGCGGACAATGG GAAAAAGAGA 251 GAGGGCATTT ACTTACCGTA ATCAATCGGC ACGAGTTTTATGCGTGCGCA 301 ATCAACTCGG GAGTATTGGA TGAGGATTTG TTTAAACGGC TGCATTGCAC351 CAACTTCATA AAATTGTGGA ATGCAGTTTC GCCTCTTGTT ATGAAAATAC 401GCGAAGAAGA ACGCAAAGAC ACAATATTTA GAGAGTTGGA AATTTTGGTT 451 GCATTATGGAAAGCAAACCC CCTAAAGGCA TCTGATTTGT GAThis corresponds to the amino acid sequence <SEQ ID 2550; ORF 745>:

m745.pep 1 MFWQLTVVSV TAVIALGTIF INKKTSKQKA TLDVILNDYQ DAQFVEADNH 51ISPYIRGTAV DDNNARIDLY EIYQNKGGQW EKERGHLLTV INRHEFYACA 101 INSGVLDEDLFKRLHCTNFI KLWNAVSPLV MKIREEERKD TIFRELEILV 151 ALWKANPLKA SDL*

a745.seq not found yet

a745.pep not found yet

The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2551>:

g746.seq 1 ATGTCCGAAA ACAAACAAAA CGAAGTCCTG ACCGGTTACG AACAGCTGAA 51ACGGCGCAAC CGCCGCCGCC TCGTAACGGC AAGCTCCCTG GTTGCCGCCT 101 CCTGCATCCTGCTGGCAGCC GCACTCAGTT CCGATCCTGC CGACAGCAAT 151 CCCGCACCGC AGGCCGGCGAAACCGGCGCA ACGGAAAGCC AAACGGCAAA 201 CACGGCACAA ACCCCTGCCT TGAAATCCGCCGCCGAAAAC GGGGAAACCG 251 CCGCCGACAA ACCGCAGGAC TTGGCAGGCG AAGACAAGCCTTCTGCCGCC 301 GACAGCGAAA TCAGCGAGCC TGAAAACGTA GGCGCGCCGC TGGTGCTGAT351 TAACGACCGG CTCGAAGACA GCAACATCAA AGGTTTGGAA GAATCCGAGA 401AACTGCAACA GGCAGAAACC GCCAAAACCG AACCGAAGCA GGCAAAACAA 451 CGCGCTGCCGAAAAAGTGTC GGCAACTGCC GACAGTACGG ATACGGTAGC 501 GGTTGAAAAA CCGAAACGCACTGCCGAACC CAAACCGCAA AAAGCGGAAC 551 GCACTGCCGA AGCCAAGCCC AAAGCCAAAGAAACCAAAAC CGCCGAAAAA 601 GTTGCCGACA AACCGAAAAC TGCTGCCGAA AAAACCAAACCGGATACGGC 651 AAAATCCGAC AGCGCGGTAA AAGAAGCGAA AAAAGCCGAC AAGGCTGAAG701 GCAAAAAGAC AGCCGAAAAA GACCGTTCGG ACGGCAAAAA ACACGAAACG 751GCGCAAAAAA CCGACAAAGC GGACAAAACC AAAACCGCCG AGAAGGAAAA 801 ATCCGGCAAGGCGGGCAAAA AAGCCGCCAT TCAGGCAGGT TATGCCGAAA 851 AAGAACGCGC CTTGAGCCTCCAGCGCAAAA TGAAGGCGGC GGGTATCGAT 901 TCGACCATCA CCGAAATCAT GACCGACAACGGCAAAGTTT ACCGCGTCAA 951 ATCAAGCAAC TATAAAAACG CAAGGGATGC CGAACGCGATTTGAACAAAC 1001 TGCGCGTGCA CGGCATCGCC GGCCAGGTAA CGAATGAATA GThis corresponds to the amino acid sequence <SEQ ID 2552; ORF 746.ng>:

g746.pep 1 MSENKQNEVL TGYEQLKRRN RRRLVTASSL VAASCILLAA ALSSDPADSN 51PAPQAGETGA TESQTANTAQ TPALKSAAEN GETAADKPQD LAGEDKPSAA 101 DSEISEPENVGAPLVLINDR LEDSNIKGLE ESEKLQQAET AKTEPKQAKQ 151 RAAEKVSATA DSTDTVAVEKPKRTAEPKPQ KAERTAEAKP KAKETKTAEK 201 VADKPKTAAE KTKPDTAKSD SAVKEAKKADKAEGKKTAEK DRSDGKKHET 251 AQKTDKADKT KTAEKEKSGK AGKKAAIQAG YAEKERALSLQRKMKAAGID 301 STITEIMTDN GKVYRVKSSN YKNARDAERD LNKLRVHGIA GQVTNE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2553>:

m746.seq 1 ATGTCCGAAA ACAAACAAAA CGAAGTCCTG AGCGGTTACG AACAACTCAA 51ACGGCGCAAC CGCCGCCGCC TCGTAACGGC AAGTTGCCTG GTTGCCGCCT 101 CCTGCATCCTGCTGGCAGCC GCCCTCAGTT CCGGCCCTGC CGAACAGACT 151 GCCGGCGAAA CAAGCGGCGTAGAAAACAAA GCGGCAGGTG CGGCACAAAC 201 CCCTGCCTTG AAATCCGCCG CCGACAAACCGCAGGACTTG GCAGGCGAAG 251 ACAAGCCTTC TGCCGCCGAC AGCGAAATCA GCGAGCCTGAAAACGTAGGC 301 GCGCCGCTGG TGCTGATTAA CGAGCGCCTC GAAGACAGCA ACATCAAAGG351 TTTGGAAGCA TCCGAGAAAC TGCAACAGGC AGAAACCGCC AAAACCGCAC 401CGAAGCAGGC AAAACAACGC GCTGCCGAAA AAGTGCCGGC AACTGCCGAC 451 AGTACGGATACGGTAGCGGT TGAAAAACCG AAACGCACTG CCGAAACAAA 501 ACCGCAAAAA GCGGAACGCACTGCCAAAGC CAAGCCCAAA GCCAAAGAAA 551 CCAAAACCGC CGAAAAAGTT GCCGACAAACCGAAAACTGC CGCCGAAAAA 601 ACCAAACCGG ATACGGCAAA ATCCGACAGC GCGGTAAAAGAAGCGAAAAA 651 AGCCGACAAG GCTGAAAGCA AAAAAACAGC CGAAAAAGAC CGTTCGGACG701 GCAAAAAACA CGAAACGGCA CAAAAAACCG ACAAAGCGGA CAAGACCAAA 751ACCGCCGAGA AGGAAAAATC CGGTAAAAAA GCCGCCATTC AGGCAGGTTA 801 TGCCGAAAAAGAACGCGCCT TAAGCCTCCA GCGCAAAATG AAGGCGGCGG 851 GTATCGATTC GACCATCACCGAAATTATGA CCGACAACGG CAAAGTTTAC 901 CGCGTCAAAT CAAGCAACTA TAAAAACGCAAGGGATGCCG AACGCGATTT 951 GAACAAATTG CGCGTACACG GTATCGCCGG TCAGGTAACGAATGAATAGThis corresponds to the amino acid sequence <SEQ ID 2554; ORF 746>:

m746.pep 1 MSENKQNEVL SGYEQLKRRN RRRLVTASCL VAASCILLAA ALSSGPAEQT 51AGETSGVENK AAGAAQTPAL KSAADKPQDL AGEDKPSAAD SEISEPENVG 101 APLVLINERLEDSNIKGLEA SEKLQQAETA KTAPKQAKQR AAEKVPATAD 151 STDTVAVEKP KRTAETKPQKAERTAKAKPK AKETKTAEKV ADKPKTAAEK 201 TKPDTAKSDS AVKEAKKADK AESKKTAEKDRSDGKKHETA QKTDKADKTK 251 TAEKEKSGKK AAIQAGYAEK ERALSLQRKM KAAGIDSTITEIMTDNGKVY 301 RVKSSNYKNA RDAERDLNKL RVHGIAGQVT NE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 746 shows 89.9% identity over a 346 aa overlap with a predicted ORF(ORF 746) from N. gonorrhoeae:

m746/g746 89.9% identity in 346 aa overlap          10        20        30        40        50 m746.pep  MSENKQNEVLSGYEQLKRRNRRRLVTASCLVAASCILLAAALSSGPAEQT----AGETSG  ||||||||||:||||||||||||||||| ||||||||||||||| ||:::    ||||:: g746  MSENKQNEVLTGYEQLKRRNRRRLVTASSLVAASCILLAAALSSDPADSNPAPQAGETGA          10        20        30        40        50        60    60        70               80        90       100      109 m746.pep  VENKAAGAAQTPALKSAA-------DKPQDLAGEDKPSAADSEISEPENVGAPLVLINER  :|:::|::||||||||||       |||||||||||||||||||||||||||||||||:| g746  TESQTANTAQTPALKSAAENGETAADKPQDLAGEDKPSAADSEISEPENVGAPLVLINDR          70        80        90       100       110       120110       120       130       140       150       160      169 m746.pep  LEDSNIKGLEASEKLQQAETAKTAPKQAKQRAAEKVPATADSTDTVAVEKPKRTAETKPQ  |||||||||| |||||||||||| |||||||||||| ||||||||||||||||||| ||| g746  LEDSNIKGLEESEKLQQAETAKTEPKQAKQRAAEKVSATADSTDTVAVEKPKRTAEPKPQ         130       140       150       160       170       180170       180       190       200       210       220      229 m746.pep  KAERTAKAKPKAKETKTAEKVADKPKTAAEKTKPDTAKSDSAVKEAKKADKAESKKTAEK  ||||||:||||||||||||||||||||||||||||||||||||||||||||||:|||||| g746  KAERTAEAKPKAKETKTAEKVADKPKTAAEKTKPDTAKSDSAVKEAKKADKAEGKKTAEK         190       200       210       220       230       240230       240       250          260       270       280 m746.pep  DRSDGKKHETAQKTDKADKTKTAEKEKSGK---KAAIQAGYAEKERALSLQRKMKAAGID  ||||||||||||||||||||||||||||||   ||||||||||||||||||||||||||| g746  DRSDGKKHETAQKTDKADKTKTAEKEKSGKAGKKAAIQAGYAEKERALSLQRKMKAAGID         250       260       270       280       290       300   290       300       310       320       330 m746.pep  STITEIMTDNGKVYRVKSSNYKNARDAERDLNKLRVHGIAGQVTNEX  ||||||||||||||||||||||||||||||||||||||||||||||| g746  STITEIMTDNGKVYRVKSSNYKNARDAERDLNKLRVHGIAGQVTNEX         310       320       330       340The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2555>:

a746.seq 1 ATGTCCGAAA ACAAACAAAA CGAAGTCCTG AGCGGTTACG AACAACTCAA 51ACGGCGCAAC CGCCGCCGCC TCGTAACGGC AAGTTGCCTG GTTGCCGCCT 101 CCTGCATCCTGCTGGCAGCC GCCCTCAGTT CCGGCCCTGC CGAACAGACT 151 GCCGGCGAAA CAAGCGGCGTAGAAAACAAA GCGGCAGGTG CGGCACAAAC 201 CCCTGCCTTG AAATCCGCCG CCGACAAACCGCAGGACTTG GCAGGCGAAG 251 ACAAGCCTTC TGCCGCCGAC AGCGAAATCA GCGAGCCTGAAAACGTAGGC 301 GCGCCGCTGG TGCTGATTAA CGACCGCCTC GAAGACAGCA ACATCAAAGG351 TTTGGAAGCA TCCGAGAAAC TGCAACAGGC AGAAACCGCC AAAACCGCAC 401CGAAGCAGGC AAAACAACGC GCTGCCGAAA AAGTGCCGGC AACTGCCGAC 451 AGTACGGATACGGTAGCGGT TGAAAAACCG AAACGCACTG CCGAAACAAA 501 ACCGCAAAAA GCGGAACGCACTGCCAAAGC CAAGCCCAAA GCCAAAGAAA 551 CCAAAACCGC CGAAAAAGTT GCCGACAAACCGAAAACTGC CGCCGAAAAA 601 ACCAAACCGG ATACGGCAAA ATCCGACAGC GCGGTAAAAGAAGCGAAAAA 651 AGCCGACAAG GCTGAAAGCA AAAAAACAGC CGAAAAAGAC CGTTCGGACG701 GCAAAAAACA CGAAACGGCA CAAAAAACCG ACAAAGCGGA CAAGACCAAA 751ACCGCCGAGA AGGAAAAATC CGGTAAAAAA GCCGCCATTC AGGCAGGTTA 801 TGCCGAAAAAGAACGCGCCT TAAGCCTCCA GCGCAAAATG AAGGCGGCGG 851 GTATCGATTC GACCATCACCGAAATTATGA CCGACAACGG CAAAGTTTAC 901 CGCGTCAAAT CAAGCAACTA TAAAAACGCAAGGGATGCCG AACGCGATTT 951 GAACAAATTG CGCGTACACG GTATCGCCGG TCAGGTAACGAATGAATAAThis corresponds to the amino acid sequence <SEQ ID 2556; ORF 746.a>:

a746.pep 1 MSENKQNEVL SGYEQLKRRN RRRLVTASCL VAASCILLAA ALSSGPAEQT 51AGETSGVENK AAGAAQTPAL KSAADKPQDL AGEDKPSAAD SEISEPENVG 101 APLVLINDRLEDSNIKGLEA SEKLQQAETA KTAPKQAKQR AAEKVPATAD 151 STDTVAVEKP KRTAETKPQKAERTAKAKPK AKETKTAEKV ADKPKTAAEK 201 TKPDTAKSDS AVKEAKKADK AESKKTAEKDRSDGKKHETA QKTDKADKTK 251 TAEKEKSGKK AAIQAGYAEK ERALSLQRKM KAAGIDSTITEIMTDNGKVY 301 RVKSSNYKNA RDAERDLNKL RVHGIAGQVT NE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 746 shows 99.7% identity over a 332 aa overlap with a predicted ORF(ORF 746) from N. meningitidis:

a746/m746; 99.7% identity in 332 aa overlap        10        20        30        40        50        60 a746.pepMSENKQNEVLSGYEQLKRRNRRRLVTASCLVAASCILLAAALSSGPAEQTAGETSGVENK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m746MSENKQNEVLSGYEQLKRRNRRRLVTASCLVAASCILLAAALSSGPAEQTAGETSGVENK        10        20        30        40        50        60        70        80        90       100       110       120 a746.pepAAGAAQTPALKSAADKPQDLAGEDKPSAADSEISEPENVGAPLVLINDRLEDSNIKGLEA|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||| m746AAGAAQTPALKSAADKPQDLAGEDKPSAADSEISEPENVGAPLVLINERLEDSNIKGLEA        70        80        90       100       110       120       130       140       150       160       170       180 a746.pepSEKLQQAETAKTAPKQAKQRAAEKVPATADSTDTVAVEKPKRTAETKPQKAERTAKAKPK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m746SEKLQQAETAKTAPKQAKQRAAEKVPATADSTDTVAVEKPKRTAETKPQKAERTAKAKPK       130       140       150       160       170       180       190       200       210       220       230       240 a746.pepAKETKTAEKVADKPKTAAEKTKPDTAKSDSAVKEAKKADKAESKKTAEKDRSDGKKHETA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m746AKETKTAEKVADKPKTAAEKTKPDTAKSDSAVKEAKKADKAESKKTAEKDRSDGKKHETA       190       200       210       220       230       240       250       260       270       280       290       300 a746.pepQKTDKADKTKTAEKEKSGKKAAIQAGYAEKERALSLQRKMKAAGIDSTITEIMTDNGKVY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m746QKTDKADKTKTAEKEKSGKKAAIQAGYAEKERALSLQRKMKAAGIDSTITEIMTDNGKVY       250       260       270       280       290       300       310       320       330 a746.pepRVKSSNYKNARDAERDLNKLRVHGIAGQVTNEX ||||||||||||||||||||||||||||||||| m746RVKSSNYKNARDAERDLNKLRVHGIAGQVTNEX        310       320       330

g747.seq not found yet

g747.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2557>:

m747.seq 1 CTGACCCCTT GGGCGGATGC ATATGCAGAT TTGCGCGGCA AAACCAAAGT 51GATGACGACC CAGATGGGTG CTTCCCGCGA TGTCAGCAAA AGCGCCAAAG 101 GTTGGAGTGTCGGTATCGGT CTGAATGTAG GCAAACAGTT GACCGACAGC 151 GTCGGTCTCG AGTTTGATCCATACTACCGT CACAAAACAA TCTACAAACC 201 CCGTGAGATT GTCTTGGACG GTGACAAAACCAAAATGGGC CGCTCCAAAT 251 CCAACGAGTA CGGCTTCCGC GTAGCCGCAA CGTTCTATAGTCAATTAAAA 301 TCAAAATAGThis corresponds to the amino acid sequence <SEQ ID 2558; ORF 747>:

m747.pep 1 LTPWADAYAD LRGKTKVMTT QMGASRDVSK SAKGWSVGIG LNVGKQLTDS 51VGLEFDPYYR HKTIYKPREI VLDGDKTKMG RSKSNEYGFR VAATFYSQLK 101 SK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2559>:

a747.seq 1 CTAACCCCTT GGGCGGATGC ATATGCAGAT TTGCGCGGCA AAACCAAAGT 51GATGACGACC CAGATGTGTG CTTCCCGCGA TGTCAGCAAA AGCGCCAAAG 101 GTTGGAGTGTCGGTATCGGT CTGAATGTAG GCAAACAGTT GACCGACAGC 151 GTCGGTCTCG AGTTTGATCCATACTACCGT CACAAAACAA TCTGCAAACC 201 CCGTGAGATT GTTTTGGACG GCGACAAAACCAAAATGGGC CGCTCCAAAT 251 CCAACGAGTA CGGCTTCCGC GTAACCGCAA CGTTCTATAGTCAATTAAAA 301 TCAAAGTAGThis corresponds to the amino acid sequence <SEQ ID 2560; ORF 747.a>:

a747.pep 1 LTPWADAYAD LRGKTKVMTT QMCASRDVSK SAKGWSVGIG LNVGKQLTDS 51VGLEFDPYYR HKTICKPREI VLDGDKTKMG RSKSNEYGFR VTATFYSQLK 101 SK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 747 shows 97.1% identity over a 102 aa overlap with a predicted ORF(ORF 746) from N. meningitidis:

a747/m747 97.1% identity in 102 aa overlap        10        20        30        40        50        60 a747.pepLTPWADAYADLRGKTKVMTTQMCASRDVSKSAKGWSVGIGLNVGKQLTDSVGLEFDPYYR|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| m747LTPWADAYADLRGKTKVMTTQMGASRDVSKSAKGWSVGIGLNVGKQLTDSVGLEFDPYYR        10        20        30        40        50        60        70        80        90       100 a747.pepHKTICKPREIVLDGDKTKMGRSKSNEYGFRVTATFYSQLKSKX|||| ||||||||||||||||||||||||||:||||||||||| m747HKTIYKPREIVLDGDKTKMGRSKSNEYGFRVAATFYSQLKSKX        70        80        90       100 a747/m80195 gi|150271 (M80195)outer membrane protein [Neisseria meningitidis] Length = 272 Score= 59.3 bits (141), Expect = 6e−09 Identities = 29/99 (29%), Positives= 51/99 (51%), Gaps = 4/99 (4%) Query: 1LTPWADAYADLRGKTKVMTTQMCASRDVSKSAKGWSVGIGLNVGKQLTDSVGLEFDPYYR 60+ PW++   DL  + K+ T      +D+++   GW  G+G N+GK+L +S  +E  P+Y+ Sbjct: 174INPWSEVKFDLNSRYKLNTGVTNLKKDINQKTNGWGFGLGANIGKKLGESASIEAGPFYK 233 Query:61 HKTICKPREIVL---DGD-KTKMGRSKSNEYGFRVTATF 95 +T  +  E  +    GD    + ++   EYG RV   F Sbjct: 234QRTYKESGEFSVTTKSGDVSLTIPKTSIREYGLRVGIKF 272The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2561>:

g748.seq 1 ATGAGTCAAA ACCAACCCGC ACAACCGACC AAACGCAATC TGTTCAAAAC 51CGCCCTTGCC GTCGGCGCAA TCGGCGCAAT CGGAGGTTAT TTCGGCGGCA 101 AAAAACAGGGCGAAACCGCC GAACGCACCG CCGAAAGCCA ACACTCGCCC 151 CAAGCCTATC CCTGCTACGGCGAACATCAG GCAGGTATCG TTACGCCGCG 201 GCAGGCGTTT TCCATTATGT GCGCCTTCGACGTAACCGCG CAAAGTGCCA 251 AGCAGCTGGA AAACCTGTTC CGCACACTGA CCGCCCGCATCGAGTTTCTC 301 ACCCAAGGCG GAGAATACCA AGACGGCGAC GACAAACTCC CGTCAGCCGG351 CAGCGGCATT TTGGGTAAAG CCTTCAACCC CGACGGATTG ACCGTTACCG 401TGGGGGTGGG CAGCAGCCTG TTTGACGGCC GGTTCGGACT CAAAGACAAA 451 AAAACGGTTCATTTGCAGGA AATGCGCGAC TTCCCCAACG ATAAGCTGCA 501 AAAAAGCTGG TGCGACGGCGATTTGAGCCT GCAAATCTGC GCCTTCACCC 551 CCGAAACCTG CCAAACCGCC CTGCGCGACATCATCAAACA CACCGCCCAA 601 ACCGCCGTCA TCCGCTGGAG TATCGACGGG TGGCAGCCTAAATCCGAACC 651 CGGCGCGATG GCGGCGCGCA ACCTGTTGGG CTTCCGAGAC GGCACGGGCA701 ACCCCAAGGT TTCCGATCCC AAAACCGCCG ACGAGGTTTT ATGGACGGGC 751GTGGCCGCCA ACAGCCTCGA CGAACCGGAG TGGGCGAAAA ACGGCAGCTA 801 TCAGGCAGTCCGCCTTATCC GCCGCTTTGT CGAGTTTTGG GACAGGACGC 851 CGCTTCAAGA GCAAACCGACATTTTCGGGC GGCGAAAATA CAGCGGGGCG 901 CCGATGGACG GCAAAAAAGA AGCCGACCAACCGGATTTCG CCAAAGACCC 951 CGAGGGTGAT ATCACGCCCA AAGACAGCCA TATGCGCCTGGCGAATCCGC 1001 GCGATCCCGA ATTCCTCAAA AAACACTGCC TCTTCCGCCG CGCCTACAGC1051 TATTCTCGCG GACCCGCCTC AAGCGGACAG CTTGATGTCG GGCTGGTGTT 1101CGTCTGCTAT CAGGCAAATC TTGCCGACGG TTTCATCTTC GTGCAAAACC 1151 TCCTCAACGGCGAACCGCTG GAAGAATACA TCAGCCCCTT CGGCGGCGGC 1201 TATTTCTTCG TCTTGCCCGGCGTGGGAAAA GGCGGATTCT TGGGACAAGG 1251 GCTGCCGGGC GTATAAThis corresponds to the amino acid sequence <SEQ ID 2562; ORF 748.ng>:

g748.pep 1 MSQNQPAQPT KRNLFKTALA VGAIGAIGGY FGGKKQGETA ERTAESQHSP 51QAYPCYGEHQ AGIVTPRQAF SIMCAFDVTA QSAKQLENLF RTLTARIEFL 101 TQGGEYQDGDDKLPSAGSGI LGKAFNPDGL TVTVGVGSSL FDGRFGLKDK 151 KTVHLQEMRD FPNDKLQKSWCDGDLSLQIC AFTPETCQTA LRDIIKHTAQ 201 TAVIRWSIDG WQPKSEPGAM AARNLLGFRDGTGNPKVSDP KTADEVLWTG 251 VAANSLDEPE WAKNGSYQAV RLIRRFVEFW DRTPLQEQTDIFGRRKYSGA 301 PMDGKKEADQ PDFAKDPEGD ITPKDSHMRL ANPRDPEFLK KHCLFRRAYS351 YSRGPASSGQ LDVGLVFVCY QANLADGFIF VQNLLNGEPL EEYISPFGGG 401YFFVLPGVGK GGFLGQGLPG V*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2563>:

m748.seq 1 ATGAGCAAAA AACAACCCGC ACAACCGACC AGGCGCACTC TTTTTAAAAC 51CGCGATCGCA GCCGGAGCAG TCGGCGCAAT CGGAGGTTAT CTCGGCGGCA 101 AAAAACAGGGCGAAACCGCC GAACGCACCG CCGAAAGCCA ACACTCGCCC 151 CAAGCCTATC CCTGCTACGGCGAACATCAG GCAGGCATCG TTACGCCGCA 201 GCAGGCGTTT TCGATTATGT GCGCCTTCGACGTAACCGCG CAAAGTGCCA 251 AGCAGCTGGA AAACCTGTTC CGCACGCTGA CCGCCCGCATCGAGTTTCTC 301 ACCCAAGGCG GCGAATACCA AGACGGCGAC GACAAACTTC CGCCAGCCGG351 CAGCGGCATT TTGGGCAAAG CCTTCAACCC CGACGGGTTG ACCGTTACCG 401TGGGGGTGGG CAGCAGCCTG TTTGACGGCC GGTTCGGACT CAAAGACAAA 451 AAACCGATTCATTTGCAGGA AATGCGCGAC TTCTCCAACG ATAAGCTGCA 501 AAAAAGCTGG TGCGACGGCGATTTGAGCCT GCAAATCTGT GCCTTCACCC 551 CCGAAACCTG CCAAGCCGCC CTGCGCGACATCATCAAACA CACCGTCCAA 601 ACCGCCGTTA TCCGTTGGAG TATCGACGGG TGGCAGCCCAAATCCGAACC 651 CGGCGCGATG GCGGCGCGCA ACCTGTTGGG CTTCAGGGAC GGCACGGGCA701 ACCCCAAAGT TTCCGATCCC AAAACTGCCG ACGAGGTTTT GTGGACGGGG 751GTGGCCGCCA ACAGCCTCGA CGAACCGGAG TGGGCGAAAA ACGGCAGCTA 801 TCAGGCAGTCCGCCTTATCC GCCACTTTGT CGAGTTTTGG GACAGGACGC 851 CGCTTCAAGA GCAAACCGACATTTTCGGGC GGCGCAAATA CAGCGGTGCG 901 CCGATGGACG GCAAAAAAGA AGCCGACCAACCGGATTTTG CCAAAGACCC 951 CGAGGGTGAT ATCACGCCCA AAGACAGCCA TATACGCCTGGCGAATCCGC 1001 GCGATCCCGA ATTCCTCAAA AAACACCGCC TCTTCCGCCG CGCCTACAGC1051 TATTCGCGCG GACTCGCCTC AAGCGGACAG CTTGATGTCG GGCTGGTGTT 1101CGTCTGCTAT CAGGCAAACC TTGCCGACGG ATTCATCTTC GTGCAAAACC 1151 TCCTCAACGGCGAACCGCTG GAAGAATACA TCAGCCCCTT CGGCGGCGGC 1201 TATTTCTTCG TCTTGCCCGGCGTGGAAAAA GGCGGCTTTT TGGGGCAAGG 1251 GCTGCTGGGC GTATAAThis corresponds to the amino acid sequence <SEQ ID 2564; ORF 748>:

m748.pep 1 MSKKQPAQPT RRTLFKTAIA AGAVGAIGGY LGGKKQGETA ERTAESQHSP 51QAYPCYGEHQ AGIVTPQQAF SIMCAFDVTA QSAKQLENLF RTLTARIEFL 101 TQGGEYQDGDDKLPPAGSGI LGKAFNPDGL TVTVGVGSSL FDGRFGLKDK 151 KPIHLQEMRD FSNDKLQKSWCDGDLSLQIC AFTPETCQAA LRDIIKHTVQ 201 TAVIRWSIDG WQPKSEPGAM AARNLLGFRDGTGNPKVSDP KTADEVLWTG 251 VAANSLDEPE WAKNGSYQAV RLIRHFVEFW DRTPLQEQTDIFGRRKYSGA 301 PMDGKKEADQ PDFAKDPEGD ITPKDSHIRL ANPRDPEFLK KHRLFRRAYS351 YSRGLASSGQ LDVGLVFVCY QANLADGFIF VQNLLNGEPL EEYISPFGGG 401YFFVLPGVEK GGFLGQGLLG V*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 748 shows 95.0% identity over a 421 aa overlap with a predicted ORF(ORF 748) from N. gonorrhoeae

m748/g748 95.0% identity in 421 aa overlap        10        20        30        40        50        60 m748.pepMSKKQPAQPTRRTLFKLAIAAGAVGAIGGYLGGKKQGETAERTAESQHSPQAYPCYGEHQ||::||||||:|:|||||:|:||:||||||:||||||||||||||||||||||||||||| g748MSQNQPAQPTKRNLFKTALAVGAIGAIGGYFGGKKQGETAERTAESQHSPQAYPCYGEHQ        10        20        30        40        50        60        70        80        90       100       110       120 m748.pepAGIVTPQQAFSIMCAFDVTAQSAKQLENLFRTLTARIEFLTQGGEYQDGDDKLPPAGSGI||||||:||||||||||||||||||||||||||||||||||||||||||||||| ||||| g748AGIVTPRQAFSIMCAFDVTAQSAKQLENLFRTLTARIEFLTQGGEYQDGDDKLPSAGSGI        70        80        90       100       110       120       130       140       150       160       170       180 m748.pepLGKAFNPDGLTVTVGVGSSLFDGRFGLKDKKPIHLQEMRDFSNDKLQKSWCDGDLSLQIC||||||||||||||||||||||||||||||| :|||||||| |||||||||||||||||| g748LGKAFNPDGLTVTVGVGSSLFDGRFGLKDKKTVHLQEMRDFPNDKLQKSWCDGDLSLQIC       130       140       150       160       170       180       190       200       210       220       230       240 m748.pepAFTPETCQAALRDIIKHTVQTAVIRWSIDGWQPKSEPGAMAARNLLGFRDGTGNPKVSDP||||||||:|||||||||:||||||||||||||||||||||||||||||||||||||||| g748AFTPETCQTALRDIIKHTAQTAVIRWSIDGWQPKSEPGAMAARNLLGFRDGTGNPKVSDP       190       200       210       220       230       240       250       260       270       280       290       300 m748.pepKTADEVLWTGVAANSLDEPEWAKNGSYQAVRLIRHFVEFWDRTPLQEQTDIFGRRKYSGA||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||| g748KTADEVLWTGVAANSLDEPEWAKNGSYQAVRLIRRFVEFWDRTPLQEQTDIFGRRKYSGA       250       260       270       280       290       300       310       320       330       340       350       360 m748.pepPMDGKKEADQPDFAKDPEGDITPKDSHIRLANPRDPEFLKKHRLFRRAYSYSRGLASSGQ|||||||||||||||||||||||||||:|||||||||||||| ||||||||||| ||||| g748PMDGKKEADQPDFAKDPEGDITPKDSHMRLANPRDPEFLKKHCLFRRAYSYSRGPASSGQ       310       320       330       340       350       360       370       380       390       400       410       420 m748.pepLDVGLVFVCYQANLADGFIFVQNLLNGEPLEEYISPFGGGYFFVLPGVEKGGFLGQGLLG|||||||||||||||||||||||||||||||||||||||||||||||| ||||||||| | g748LDVGLVFVCYQANLADGFIFVQNLLNGEPLEEYISPFGGGYFFVLPGVGKGGFLGQGLPG       370       380       390       400       410       420 m748.pep VX|| g748 VXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2565>:

a748.seq 1 ATGAGCAAAA ACCAACCCGC ACAACCGACC AGGCGCACTC TTTTTAAAAC 51CGCGATCGCA GCTGGAGCAG TCGGCGCAAT CGGAGGTTAT CTCGGCGGCA 101 AAAAACGGGGCGAAACCGCC GAACGCACCG CCGAAAGCCA ACACTCGCCC 151 CAAGCCTATC CCTGCTACGGCGAACATCAG GCAGGCATCG TTACGCCGCA 201 GCAGGCGTTT TCGATTATGT GCGCCTTCGACGTAACCGCG CAAAGTGCCA 251 AGCAGCTGGA AAACCTGTTC CGCACGCTGA CCGCCCGCATCGAGTTTCTC 301 ACCCAAGGCG GCGAATACCA AGACGGCGAC GACAAACTTC CGCCAGCCGG351 CAGCGGCATT TTGGGCAAAG CCTTCAACCC CGACGGGTTG ACCGTTACCG 401TGGGGGTGGG CAGCAGCCTG TTTGACGGCC GGTTCGGACT CAAAGACAAA 451 AAACCGATTCATTTGCAGGA AATGCGCGAC TTCTCCAACG ATAAGCTGCA 501 AAAAAGCTGG TGCGACGGCGATTTGAGCCT GCAAATCTGT GCCTTCACCC 551 CCGAAACCTG CCAAGCCGCC CTGCGCGACATCATCAAACA CACCGTCCAA 601 ACCGCCGTTA TCCGCTGGAG TATCGACGGG TGGCAGCCTAAATCCGAACC 651 CGGCGCGATG GCGGCGCGCA ACCTGTTGGG CTTCCGCGAC GGCACGGGCA701 ACCCCAAAGT TTCCGACCCC AAAACTGCCG ACGAGGTTTT GTGGACGGGG 751GTGGCCGCCA ACAGCCTCGA CGAACCGGAG TGGGCGAAAA ACGGCAGCTA 801 TCAGGCAGTCCGCCTTATCC GCCACTTTGT TGAGTTTTGG GACAGGACGC 851 CGCTTCAAGA GCAAACCGACATTTTCGGGC GGCGCAAATA CAGCGGCGCG 901 CCGATGGACG GCAAAAAAGA AGCCGACCAACCGGATTTTG CCAAAGACCC 951 CGAGGGGAAT ACCACGCCCA AAGACAGCCA TATACGCCTGGCGAATCCGC 1001 GCGATCCCGA GTTCCTTAAA AAACACCGCC TCTTCCGCCG CGCCTACAGC1051 TATTCGCGCG GACTCGCCTC AAGCGGACAG CTTGATGTCG GGCTGGTGTT 1101CGTCTGCTAT CAGGCAAACC TTGCCGACGG ATTCATCTTC GTGCAAAACC 1151 TCCTCAACGGCGAACCGCTG GAAGAATACA TCAGCCCCTT CGGCGGCGGC 1201 TATTTCTTCG TCTTGCCCGGCGTGGAAAAA GGCGGCTTTT TGGGGCAAGG 1251 GCTGCTGGGC GTATAAThis corresponds to the amino acid sequence <SEQ ID 2566; ORF 748.a>:

a748.pep 1 MSKNQPAQPT RRTLFKTAIA AGAVGAIGGY LGGKKRGETA ERTAESQHSP 51QAYPCYGEHQ AGIVTPQQAF SIMCAFDVTA QSAKQLENLF RTLTARIEFL 101 TQGGEYQDGDDKLPPAGSGI LGKAFNPDGL TVTVGVGSSL FDGRFGLKDK 151 KPIHLQEMRD FSNDKLQKSWCDGDLSLQIC AFTPETCQAA LRDIIKHTVQ 201 TAVIRWSIDG WQPKSEPGAM AARNLLGFRDGTGNPKVSDP KTADEVLWTG 251 VAANSLDEPE WAKNGSYQAV RLIRHFVEFW DRTPLQEQTDIFGRRKYSGA 301 PMDGKKEADQ PDFAKDPEGN TTPKDSHIRL ANPRDPEFLK KHRLFRRAYS351 YSRGLASSGQ LDVGLVFVCY QANLADGFIF VQNLLNGEPL EEYISPFGGG 401YFFVLPGVEK GGFLGQGLLG V*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N meningitidisORF 748 shows 99.0% identity over a 421 aa overlap with a predicted ORF(ORF 748) from N. meningitidis:

a748/m748 99.0% identity in 421 aa overlap        10        20        30        40        50        60 a748.pepMSKNQPAQPTRRTLFKTAIAAGAVGAIGGYLGGKKRGETAERTAESQHSPQAYPCYGEHQ|||:|||||||||||||||||||||||||||||||:|||||||||||||||||||||||| m748MSKKQPAQPTRRTLFKTAIAAGAVGAIGGYLGGKKQGETAERTAESQHSPQAYPCYGEHQ        10        20        30        40        50        60        70        80        90       100       110       120 a748.pepAGIVTPQQAFSIMCAFDVTAQSAKQLENLFRTLTARIEFLTQGGEYQDGDDKLPPAGSGI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m748AGIVTPQQAFSIMCAFDVTAQSAKQLENLFRTLTARIEFLTQGGEYQDGDDKLPPAGSGI        70        80        90       100       110       120       130       140       150       160       170       180 a748.pepLGKAFNPDGLTVTVGVGSSLFDGRFGLKDKKPIHLQEMRDFSNDKLQKSWCDGDLSLQIC|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m748LGKAFNPDGLTVTVGVGSSLFDGRFGLKDKKPIHLQEMRDFSNDKLQKSWCDGDLSLQIC       130       140       150       160       170       180       190       200       210       220       230       240 a748.pepAFTPETCQAALRDIIKHTVQTAVIRWSIDGWQPKSEPGAMAARNLLGFRDGTGNPKVSDP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m748AFTPETCQAALRDIIKHTVQTAVIRWSIDGWQPKSEPGAMAARNLLGFRDGTGNPKVSDP       190       200       210       220       230       240       250       260       270       280       290       300 a748.pepKTADEVLWTGVAANSLDEPEWAKNGSYQAVRLIRHFVEFWDRTPLQEQTDIFGRRKYSGA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m748KTADEVLWTGVAANSLDEPEWAKNGSYQAVRLIRHFVEFWDRTPLQEQTDIFGRRKYSGA       250       260       270       280       290       300       310       320       330       340       350       360 a748.pepPMDGKKEADQPDFAKDPEGNTTPKDSHIRLANPRDPEFLKKHRLFRRAYSYSRGLASSGQ|||||||||||||||||||: ||||||||||||||||||||||||||||||||||||||| m748PMDGKKEADQPDFAKDPEGDITPKDSHIRLANPRDPEFLKKHRLFRRAYSYSRGLASSGQ       310       320       330       340       350       360       370       380       390       400       410       420 a748.pepLDVGLVFVCYQANLADGFIFVQNLLNGEPLEEYISPFGGGYFFVLPGVEKGGFLGQGLLG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m748LDVGLVFVCYQANLADGFIFVQNLLNGEPLEEYISPFGGGYFFVLPGVEKGGFLGQGLLG       370       380       390       400       410       420 a748.pep VX|| m748 VXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2567>:

g749.seq 1 ATGAGAAAAT TCAATTTGAC CGCATTGTCC GTGATGCTTG CCTTGGGTTT 51GACCGCGTGC CAGCCGCCGG AGGCGGAGAA AGCCGCGCCG GCCGCGTCCG 101 GTGAGACCCAATCCGCCAAC GAAGGCGGTT CGGTCGGTAT CGCCGTCAAC 151 GACAATGCCT GCGAACCGATGAATCTGACC GTGCCGAGCG GACAGGTTGT 201 GTTCAATATT AAAAACAACA GCGGCCGCAAGCTCGAATGG GAAATCCTGA 251 AGGGCGTGAT GGTGGTGGAC GAACGCGAAA ATATCGCCCCGGGGCTTTCC 301 GACAAAATGA CCGTAAccct GCTGCCGGGC GAATACGAAA TGACCTGCGG351 CCTTTTGACC AATCCGCGCG GCAAGCTGGT GGTAGCCGAC AGCGGCTTTA 401AAGACACCGC CAACGAAGCG GATTTGGAAA AACTGCCCCA ACCGCTCGCC 451 GACTATAAAGCCTACGTTCA AGGCGAGGTT AAAGAGCTGG CGGCGAAAAC 501 CAAAACCTTT ACCGAAGCCGTCAAAGCAGG CGACATTGAA AAGGCGAAAT 551 CCCTGTTTGC CGCCACCCGC GTCCATTACGAACGCATCGA ACCGATTGCC 601 GAGCTTTTCA GCGAACTCGA CCCCGTCATC GATGCGTGTGAAGACGACTT 651 CAAAGACGGT GCGAAAGATG CCGGGTTTAC CGGCTTCCAC CGTATCGAAC701 ACGCCCTTTG GGTGGAAAAA GACGTATCCG GCGTGAAGGA AACCGCGGCC 751AAACTGATGA CCGATGTCGA AGCCCTGCAA AAAGAAATCG ACGCATTGGC 801 GttccctCCGGGCAAAGTGG TCGGCGGCGC GTCCGAACTG ATTGAAGAAG 851 CGGCGGGCAG TAAAATCAGCGGCGAAGAAG ACCgttaCAG CCACACCGAT 901 TTGAGCGACT TCCAAGCTAA TGCGGACGGATCTAAAAAAA TCGTCGATTT 951 GTTCCGTCCG TTGATTGAGG CCAAAAACAA AGCCTTGTTGGAAAAAACCG 1001 ATACCAACTT CAAACAGGTC AACGAAATTC TGGCGAAATA CCGCACCAAA1051 GACGGTTTTG AAACCTACGA CAAGCTGAGC GAAGCCGACC GCAAAGCATT 1101ACAGGCTCCT ATTAACGCGC TTGCCGAAGA CCTTGCCCAA CTTCGCGGCA 1151 TACTCGGCTTGAAATAAThis corresponds to the amino acid sequence <SEQ ID 2568; ORF 749.ng>:

g749.pep 1 MRKFNLTALS VMLALGLTAC QPPEAEKAAP AASGETQSAN EGGSVGIAVN 51DNACEPMNLT VPSGQVVFNI KNNSGRKLEW EILKGVMVVD ERENIAPGLS 101 DKMTVTLLPGEYEMTCGLLT NPRGKLVVAD SGFKDTANEA DLEKLPQPLA 151 DYKAYVQGEV KELAAKTKTFTEAVKAGDIE KAKSLFAATR VHYERIEPIA 201 ELFSELDPVI DACEDDFKDG AKDAGFTGFHRIEHALWVEK DVSGVKETAA 251 KLMTDVEALQ KEIDALAFPP GKVVGGASEL IEEAAGSKISGEEDRYSHTD 301 LSDFQANADG SKKIVDLFRP LIEAKNKALL EKTDTNFKQV NEILAKYRTK351 DGFETYDKLS EADRKALQAP INALAEDLAQ LRGILGLK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2569>:

m749.seq 1 ATGAGAAAAT TCAATTTGAC CGCATTGTCC GTGATGCTTG CCTTAGGTTT 51GACCGCGTGC CAGCCGCCGG AGGCGGAGAA AGCTGCGCCG GCAGCGTCCG 101GTGAGGCGCA AACCGCCAAC GAGGGCGGTT CGGTCAGTAT CGCCGTCAAC 151GACAATGCCT GCGAACCGAT GGAACTGACC GTGCCGAGCG GACAGGTTGT 201GTTCAATATT AAAAACAACA GCGGCCGCAA GCTCGAATGG GAAATCCTGA 251AAGGCGTGAT GGTGGTGGAC GAGCGCGAAA ACATCGCCCC CGGACTTTCC 301GATAAAATGA CCGTCACCCT GTTGCCGGGC GAATACGAAA TGACTTGCGG 351TCTTTTGACC AATCCGCGCG GCAAGCTGGT GGTAACCGAC AGCGGCTTTA 401AAGACACCGC CAACGAAGCG GATTTGGAAA AACTGTCCCA ACCGCTCGCC 451GACTATAAAG CCTACGTTCA AGGCGAGGTT AAAGAGCTGG TGGCGAAAAC 501CAAAACTTTT ACCGAAGCCG TCAAAGCAGG CGACATTGAA AAGGCGAAAT 551CCCTGTTTGC CGACACCCGC GTCCATTACG AACGCATCGA ACCGATTGCC 601GAGCTTTTCA GCGAACTCGA CCCCGTCATC GATGCGCGTG AAGACGACTT 651CAAAGACGGC GCGAAAGATG CCGGATTTAC CGGCTTTCAC CGTATCGAAT 701ACGCCCTTTG GGTGGAAAAA GACGTGTCCG GCGTGAAGGA AATTGCAGCG 751AAACTGATGA CCGATGTCGA AGCCCTGCAA AAAGAAATCG ACGCATTGGC 801GTTTCCTCCG GGCAAGGTGG TCGGCGGCGC GTCCGAACTG ATTGAAGAAG 851TGGCGGGCAG TAAAATCAGC GGCGAAGAAG ACCGGTACAG CCACACCGAT 901TTGAGCGACT TCCAAGCCAA TGTGGACGGA TCTAAAAAAA TCGTCGATTT 951GTTCCGTCCG CTGATCGAGG CCAAAAACAA AGCCTTGTTG GAAAAAACCG 1001ATACCAACTT CAAACAGGTC AACGAAATTC TGGCGAAATA CCGGACTAAA 1051GACGGTTTTG AAACCTACGA CAAGCTGGGC GAAGCCGACC GCAAAGCGTT 1101ACAGGCCTCT ATTAACGCGC TTGCCGAAGA CCTTGCCCAA CTTCGCGGCA 1151TACTCGGCTT GAAATAAThis corresponds to the amino acid sequence <SEQ ID 2570; ORF 749>:

m749.pep 1 MRKFNLTALS VMLALGLTAC QPPEAEKAAP AASGEAQTAN EGGSVSIAVN 51DNACEPMELT VPSGQVVFNI KNNSGRKLEW EILKGVMVVD ERENIAPGLS 101DKMTVTLLPG EYEMTCGLLT NPRGKLVVTD SGFKDTANEA DLEKLSQPLA 151DYKAYVQGEV KELVAKTKTF TEAVKAGDIE KAKSLFADTR VHYERIEPIA 201ELFSELDPVI DAREDDFKDG AKDAGFTGFH RIEYALWVEK DVSGVKEIAA 251KLMTDVEALQ KEIDALAFPP GKVVGGASEL IEEVAGSKIS GEEDRYSHTD 301LSDFQANVDG SKKIVDLFRP LIEAKNKALL EKTDTNFKQV NEILAKYRTK 351DGFETYDKLG EADRKALQAS INALAEDLAQ LRGILGLK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 749 shows 96.1% identity over a 388 aa overlap with a predicted ORF(ORF 749) from N. gonorrhoeae

m749/g749 96.1% identity in 388 aa overlap        10        20        30        40        50        60 m749.pepMRKFNLTALSVMLALGLTACQPPEAEKAAPAASGEAQTANEGGSVSIAVNDNACEPMELT|||||||||||||||||||||||||||||||||||:|:|||||||:|||||||||||:|| g749MRKFNLTALSVMLALGLTACQPPEAEKAAPAASGETQSANEGGSVGIAVNDNACEPMNLT        10        20        30        40        50        60        70        80        90       100       110       120 m749.pepVPSGQVVFNIKNNSGRKLEWEILKGVMVVDERENIAPGLSDKMTVTLLPGEYEMTCGLLT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g749VPSGQVVFNIKNNSGRKLEWEILKGVMVVDERENIAPGLSDKMTVTLLPGEYEMTCGLLT        70        80        90       100       110       120       130       140       150       160       170       180 m749.pepNPRGKLVVTDSGFKDTANEADLEKLSQPLADYKAYVQGEVKELVAKTKTFTEAVKAGDIE||||||||:|||||||||||||||| |||||||||||||||||:|||||||||||||||| g749NPRGKLVVADSGFKDTANEADLEKLPQPLADYKAYVQGEVKELAAKTKTFTEAVKAGDIE       130       140       150       160       170       180       190       200       210       220       230       240 m749.pepKAKSLFADTRVHYERIEPIAELFSELDPVIDAREDDFKDGAKDAGFTGFHRIEYALWVEK ||||||||||||||||||||||||||||||| ||||||||||||||||||||:|||||| g749KAKSLFAATRVHYERIEPIAELFSELDPVIDACEDDFKDGAKDAGFTGFHRIEHALWVEK       190       200       210       220       230       240       250       260       270       280       290       300 m749.pepDVSGVKEIAAKLMTDVEALQKEIDALAFPPGKVVGGASELIEEVAGSKISGEEDRYSHTD ||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||| g749DVSGVKETAAKLMTDVEALQKEIDALAFPPGKVVGGASELIEEAAGSKISGEEDRYSHTD       250       260       270       280       290       300       310       320       330       340       350       360 m749.pepLSDFQANVDGSKKIVDLFRPLIEAKNKALLEKTDTNFKQVNEILAKYRTKDGFETYDKLG|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||: g749LSDFQANADGSKKIVDLFRPLIEAKNKALLEKTDTNFKQVNEILAKYRTKDGFETYDKLS       310       320       330       340       350       360       370       380       389 m749.pep EADRKALQASINALAEDLAQLRGILGLKX||||||||| ||||||||||||||||||| g749 EADRKALQAPINALAEDLAQLRGILGLKX       370       380The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2571>:

a749.seq 1 ATGAGAAAAT TCAATTTGAC CGCATTGTCC GTGATGCTTG CCTTAGGTTT 51GACCGCGTGC CAGCCGCCGG AGGCGGAGAA AGCTGCGCCG GCAGCGTCCG 101GTGAGGCGCA AACCGCCAAC GAGGGCGGTT CGGTCAGTAT CGCCGTCAAC 151GACAATGCCT GCGAACCGAT GGAACTGACC GTGCCGAGCG GACAGGTTGT 201GTTCAATATT AAAAACAACA GCGGCCGCAA GCTCGAATGG GAAATCCTGA 251AAGGCGTGAT GGTGGTGGAC GAGCGCGAAA ACATCGCCCC CGGACTTTCC 301GATAAAATGA CCGTCACCCT GTTGCCGGGC GAATACGAAA TGACTTGCGG 351TCTTTTGACC AATCCGCGCG GCAAGCTGGT GGTAACCGAC AGCGGCTTTA 401AAGACACCGC CAACGAAGCG GATTTGGAAA AACTGTCCCA ACCGCTCGCC 451GACTATAAAG CCTATGTTCA AGGCGAAGTC AAAGAGCTGG TGGCGAAAAC 501CAAAACCTTT ACCGAAGCCG TCAAAGCAGG CGACATTGAA AAGGCGAAAT 551CCCTGTTTGC CGACACCCGC GTCCATTACG AACGCATCGA ACCGATTGCC 601GAGCTTTTCA GCGAACTCGA CCCCGTCATC GATGCGCGTG AAGACGACTT 651CAAAGACGGC GCGAAAGATG CCGGATTTAC CGGCTTCCAC CGTATCGAAT 701ACGCCCTTTG GGTGGAAAAA GACGTGTCCG GCGTGAAGGA AATTGCAGCG 751AAACTGATGA CCGATGTCGA AGCCCTGCAA AAAGAAATCG ACGCATTGGC 801GTTTCCTCCG GGCAAGGTGG TCGGCGGCGC GTCCGAACTG ATTGAAGAAG 851TGGCGGGCAG TAAAATCAGC GGCGAAGAAG ACCGGTACAG CCACACCGAT 901TTGAGCGACT TCCAAGCCAA TGTGGACGGA TCGAAAAAAA TCGTCGATTT 951GTTCCGTCCG TTGATCGAGA CCAAAAACAA AGCCTTGTTG GAAAAAACCG 1001ATACCAACTT CAAACAGGTC AACGAAATTC TGGCGAAATA CCGGACTAAA 1051GACGGTTTTG AAACCTACGA CAAGCTGGGC GAAGCCGACC GCAAAGCGTT 1101ACAGGCCTCT ATTAACGCGC TTGCCGAAGA CCTTGCCCAA CTTCGCGGCA 1151TACTCGGCTT GAAATAAThis corresponds to the amino acid sequence <SEQ ID 2572; ORF 749.a>:

a749.pep 1 MRKFNLTALS VMLALGLTAC QPPEAEKAAP AASGEAQTAN EGGSVSIAVN 51DNACEPMELT VPSGQVVFNI KNNSGRKLEW EILKGVMVVD ERENIAPGLS 101DKMTVTLLPG EYEMTCGLLT NPRGKLVVTD SGFKDTANEA DLEKLSQPLA 151DYKAYVQGEV KELVAKTKTF TEAVKAGDIE KAKSLFADTR VHYERIEPIA 201ELFSELDPVI DAREDDFKDG AKDAGFTGFH RIEYALWVEK DVSGVKEIAA 251KLMTDVEALQ KEIDALAFPP GKVVGGASEL IEEVAGSKIS GEEDRYSHTD 301LSDFQANVDG SKKIVDLFRP LIETKNKALL EKTDTNFKQV NEILAKYRTK 351DGFETYDKLG EADRKALQAS INALAEDLAQ LRGILGLK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N meningitidisORF 749 shows 99.7% identity over a 388 aa overlap with a predicted ORF(ORF 749) from N. meningitidis:

a749/m749 99.7% identity in 388 aa overlap        10        20        30        40        50        60 a749.pepMRKFNLTALSVMLALGLTACQPPEAEKAAPAASGEAQTANEGGSVSIAVNDNACEPMELT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m749MRKFNLTALSVMLALGLTACQPPEAEKAAPAASGEAQTANEGGSVSIAVNDNACEPMELT        10        20        30        40        50        60        70        80        90       100       110       120 a749.pepVPSGQVVFNIKNNSGRKLEWEILKGVMVVDERENIAPGLSDKMTVTLLPGEYEMTCGLLT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m749VPSGQVVFNIKNNSGRKLEWEILKGVMVVDERENIAPGLSDKMTVTLLPGEYEMTCGLLT        70        80        90       100       110       120       130       140       150       160       170       180 a749.pepNPRGKLVVTDSGFKDTANEADLEKLSQPLADYKAYVQGEVKELVAKTKTFTEAVKAGDIE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m749NPRGKLVVTDSGFKDTANEADLEKLSQPLADYKAYVQGEVKELVAKTKTFTEAVKAGDIE       130       140       150       160       170       180       190       200       210       220       230       240 a749.pepKAKSLFADTRVHYERIEPIAELFSELDPVIDAREDDFKDGAKDAGFTGFHRIEYALWVEK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m749KAKSLFADTRVHYERIEPIAELFSELDPVIDAREDDFKDGAKDAGFTGFHRIEYALWVEK       190       200       210       220       230       240       250       260       270       280       290       300 a749.pepDVSGVKEIAAKLMTDVEALQKEIDALAFPPGKVVGGASELIEEVAGSKISGEEDRYSHTD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m749DVSGVKEIAAKLMTDVEALQKEIDALAFPPGKVVGGASELIEEVAGSKISGEEDRYSHTD       250       260       270       280       290       300       310       320       330       340       350       360 a749.pepLSDFQANVDGSKKIVDLFRPLIETKNKALLEKTDTNFKQVNEILAKYRTKDGFETYDKLG|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| m749LSDFQANVDGSKKIVDLFRPLIEAKNKALLEKTDTNFKQVNEILAKYRTKDGFETYDKLG       310       320       330       340       350       360       370       380       389 a749.pep EADRKALQASINALAEDLAQLRGILGLKX||||||||||||||||||||||||||||| m749 EADRKALQASINALAEDLAQLRGILGLKX       370       380The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2573>:

g750.seq 1 GTGAAACCGC GTTTTTATTG GGCAGcctGC GCCGTCCTGC CGGCCGCCTG 51TTCGCCCGAA CCTGCCGCCG AAAAAACTGT ATccgCCGCA TCCCAAGCCG 101CATCCACACC TGTCGCCACG CTGACCGTGC CGACCGCGCG GGGCGATGCC 151GTTGTGCCGA AGAATCCCGA ACgcgtcgcc gtgtAcgaCt ggGCGGCGTt 201ggaTACGCTG ACCGAGCCGG GCGTGAATGT GGGCGCAACC ACCGCGCCGG 251TGCGCGTGGA CTATTTGCAG CCTGCATTTG ACAAGGCGGC AACGGTGGGG 301ACGCTGTTTG AGCCCGATTG CGAATCCCTG CACCGCCACA ATCCGCAGTT 351TGTCATTACC GGCGGGCCGG GTGCGGAAGC GTATGAACAG TTGGCGAAAA 401ACGCGACCAC CATAGATTTG ACGGTGGACA ACGGCAATAT CCGCACCAGC 451GGCGAGAAGC AGATGGAGAC CCTGTCGCGG ATTTTCGGTA AGGAAGCGCG 501CGTGGCGGAA TTGAATGCGC AGATTGACGC GCTGTTCGCC CAAAAGCGCG 551AAGCCGCCAA AGGCAAAGGA CGCGGGCTGG TGCTGTCGGT TACAGGCAAC 601AAGGTGTCCG CCTTCGGCAC GCAATCGCGG TTGGCAAGTT GGATACACGG 651CGACATCGGC CTGCCGCCCG TGGACGAATC TTTACGCAAC GAAGGGCACG 701GGCAGCCCGT TTCCTTCGAA TACATCAAAG AGAAAAACCC CGGCTGGATT 751TTCATCATCG ACCGCACCGC CGCCATCGGG CAGGAAGGGC CGGCTGCCGT 801GGAAGTGTTG GATAACGCGC TGGTATGCGG CACGAACGCT TGGAAGCGCA 851AGCAAATCAT CGTCATGCCT GCCGCGAACT ACATTGTCGC GGGCGGCGCG 901CGGCAGTTGA TACAGGCGGC GGAACAGTTG AAGGCGGCGT TTGAAAAGGC 951AGAACCCGTT GCGGCGCAGT AGThis corresponds to the amino acid sequence <SEQ ID 2574; ORF 750.ng>:

g750.pep 1 VKPRFYWAAC AVLPAACSPE PAAEKTVSAA SQAASTPVAT LTVPTARGDA 51VVPKNPERVA VYDWAALDTL TEPGVNVGAT TAPVRVDYLQ PAFDKAATVG 101TLFEPDCESL HRHNPQFVIT GGPGAEAYEQ LAKNATTIDL TVDNGNIRTS 151GEKQMETLSR IFGKEARVAE LNAQIDALFA QKREAAKGKG RGLVLSVTGN 201KVSAFGTQSR LASWIHGDIG LPPVDESLRN EGHGQPVSFE YIKEKNPGWI 251FIIDRTAAIG QEGPAAVEVL DNALVCGTNA WKRKQIIVMP AANYIVAGGA 301RQLIQAAEQL KAAFEKAEPV AAQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2575>:

m750.seq 1 GTGAAACCGC GTTTTTATTG GGCAGCCTGC GCCGTCCTGC TGACCGCCTG 51TTCGCCCGAA CCTGCCGCCG AAAAAACTGT ATCCGCCGCA TCCGCATCTG 101CCGCCACGCT GACCGTGCCG ACCGCGCGGG GCGATGCCGT TGTGCCGAAG 151AATCCCGAAC GCGTCGCCGT GTACGACTGG GCGGCGTTGG ATACGCTGAC 201CGAATTGGGC GTGAATGTGG GCGCAACCAC CGCGCCGGTG CGCGTGGATT 251ATTTGCAGCC TGCATTTGAC AAGGCGGCAA CGGTGGGGAC GCTGTTCGAG 301CCCGATTACG AAGCCCTGCA CCGCTACAAT CCTCAGCTTG TCATTACCGG 351CGGGCCGGGC GCGGAAGCGT ATGAACAGTT AGCGAAAAAC GCGACCACCA 401TAGATCTGAC GGTGGACAAC GGCAATATCC GCACCAGCGG CGAAAAGCAG 451ATGGAGACCT TGGCGCGGAT TTTCGGCAAG GAAGCGCGCG CGGCGGAATT 501GAAGGCGCAG ATTGACGCGC TGTTCGCCCA AACGCGCGAA GCCGCCAAAG 551GCAAAGGACG CGGGCTGGTG CTGTCGGTTA CGGGCAACAA GGTGTCCGCC 601TTCGGCACGC AGTCGCGGTT GGCAAGTTGG ATACACGGCG ACATCGGCCT 651ACCGCCTGTA GACGAATCTT TACGCAACGA GGGGCACGGG CAGCCTGTTT 701CCTTCGAATA CATCAAAGAG AAAAACCCCG ATTGGATTTT CATCATCGAC 751CGTACCGCCG CCATCGGGCA GGAAGGGCCG GCGGCTGTCG AAGTATTGGA 801TAACGCGCTG GTACGCGGCA CGAACGCTTG GAAGCGCAAG CAAATCATCG 851TCATGCCTGC CGCGAACTAC ATTGTCGCGG GCGGCGCGCG GCAGTTGATT 901CAGGCGGCGG AGCAGTTGAA GGCGGCGTTT AAAAAGGCAG AACCCGTTGC 951GGCGGGGAAA AAGTAGThis corresponds to the amino acid sequence <SEQ ID 2576; ORF 750>:

m750.pep 1 VKPRFYWAAC AVLLTACSPE PAAEKTVSAA SASAATLTVP TARGDAVVPK 51NPERVAVYDW AALDTLTELG VNVGATTAPV RVDYLQPAFD KAATVGTLFE 101PDYEALHRYN PQLVITGGPG AEAYEQLAKN ATTIDLTVDN GNIRTSGEKQ 151METLARIFGK EARAAELKAQ IDALFAQTRE AAKGKGRGLV LSVTGNKVSA 201FGTQSRLASW IHGDIGLPPV DESLRNEGHG QPVSFEYIKE KNPDWIFIID 251RTAAIGQEGP AAVEVLDNAL VRGTNAWKRK QIIVMPAANY IVAGGARQLI 301QAAEQLKAAF KKAEPVAAGK K*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 750 shows 93.8% identity over a 322 aa overlap with a predicted ORF(ORF 750) from N. gonorrhoeae

m750/g750 93.8% identity in 322 aa overlap        10        20        30            40        50 m750.pepVKPRFYWAACAVLLTACSPEPAAEKTVSAASASA----ATLTVPTARGDAVVPKNPERVA||||||||||||| :|||||||||||||||| :|    |||||||||||||||||||||| g750VKPRFYWAACAVLPAACSPEPAAEKTVSAASQAASTPVATLTVPTARGDAVVPKNPERVA        10        20        30        40        50        60  60        70        80        90       100       110 m750.pepVYDWAALDTLTELGVNVGATTAPVRVDYLQPAFDKAATVGTLFEPDYEALHRYNPQLVIT|||||||||||| ||||||||||||||||||||||||||||||||| |:|||:|||:||| g750VYDWAALDTLTEPGVNVGATTAPVRVDYLQPAFDKAATVGTLFEPDCESLHRHNPQFVIT        70        80        90       100       110       120 120       130       140       150       160       170 m750.pepGGPGAEAYEQLAKNATTIDLTVDNGNIRTSGEKQMETLARIFGKEARAAELKAQIDALFA||||||||||||||||||||||||||||||||||||||:||||||||:|||:|||||||| g750GGPGAEAYEQLAKNATTIDLTVDNGNIRTSGEKQMETLSRIFGKEARVAELNAQIDALFA       130       140       150       160       170       180 180       190       200       210       220       230 m750.pepQTREAAKGKGRGLVLSVTGNKVSAFGTQSRLASWIHGDIGLPPVDESLRNEGHGQPVSFE ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g750QKREAAKGKGRGLVLSVTGNKVSAFGTQSRLASWIHGDIGLPPVDESLRNEGHGQPVSFE       190       200       210       220       230       240 240       250       260       270       280       290 m750.pepYIKEKNPDWIFIIDRTAAIGQEGPAAVEVLDNALVRGTNAWKRKQIIVMPAANYIVAGGA |||||||||||||||||||||||||||||||||| |||||||||||||||||||||||| g750YIKEKNPGWIFIIDRTAAIGQEGPAAVEVLDNALVCGTNAWKRKQIIVMPAANYIVAGGA       250       260       270       280       290       300 300       310       320 m750.pep RQLIQAAEQLKAAFKKAEPVAAGKKX||||||||||||||:||||||| g750 RQLIQAAEQLKAAFEKAEPVAAQX       310       320The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2577>:

a750.seq 1 GTGAAACCGC GTTTTTATTG GGCAGCCTGC GCCGTCCTGC TGACCGCCTG 51TTCGCCCGAA CCTGCCGCCG AAAAAACTGT ATCCGCCGCA TCCGCATCTG 101CCGCCACACT GACCGTGCCG ACCGCGCGGG GCGATGCCGT TGTGCCGAAG 151AATCCCGAAC GCGTCGCCGT GTACGACTGG GCGGCGTTGG ATACGCTGAC 201CGAATTGGGT GTGAATGTGG GCGCAACCAC CGCGCCGGTG CGCGTGGATT 251ATTTGCAGCC TGCATTTGAC AAGGCGGCAA CGGTGGGGAC GCTGTTCGAG 301CCCGATTACG AAGCCCTGCA CCGCTACAAT CCTCAGCTTG TCATTACCGG 351CGGGCCGGGC GCGGAAGCGT ATGAACAGTT GGCGAAAAAC GCGACCACCA 401TAGATCTGAC GGTGGACAAC GGCAATATCC GCACCAGCGG CGAAAAGCAG 451ATGGAGACCT TGGCGCGGAT TTTCGGCAAG GAAGCGCGCG CGGCGGAATT 501GAAGGCGCAG ATTGACGCGC TGTTCGCCCA AACGCGCGAA GCCGCCAAAG 551GCAAAGGACG CGGGCTGGTG CTGTCGGTTA CGGGCAACAA GGTGTCCGCC 601TTCGGCACGC AGTCGCGGTT GGCAAGTTGG ATACACGGCG ACATCGGCCT 651ACCGCCTGTA GACGAATCTT TACGCAACGA GGGGCACGGG CAGCCTGTTT 701CCTTCGAATA CATCAAAGAG AAAAACCCCG ATTGGATTTT CATCATCGAC 751CGTACCGCCG CCATCGGGCA GGAAGGGCCG GCGGCTGTCG AAGTATTGGA 801TAACGCGCTG GTACGCGGCA CGAACGCTTG GAAGCGCAAG CAAATCATCG 851TCATGCCTGC CGCGAACTAC ATTGTCGCGG GCGGCTCGCG GCAGTTGATT 901CAGGCGGCGG AGCAGTTGAA GGAGGCGTTT GAAAAGGCAG AACCCGTTGC 951GGCGGGGAAA GAGTAGThis corresponds to the amino acid sequence <SEQ ID 2578; ORF 750.a>:

a750.pep 1 VKPRFYWAAC AVLLTACSPE PAAEKTVSAA SASAATLTVP TARGDAVVPK 51NPERVAVYDW AALDTLTELG VNVGATTAPV RVDYLQPAFD KAATVGTLFE 101PDYEALHRYN PQLVITGGPG AEAYEQLAKN ATTIDLTVDN GNIRTSGEKQ 151METLARIFGK EARAAELKAQ IDALFAQTRE AAKGKGRGLV LSVTGNKVSA 201FGTQSRLASW IHGDIGLPPV DESLRNEGHG QPVSFEYIKE KNPDWIFIID 251RTAAIGQEGP AAVEVLDNAL VRGTNAWKRK QIIVMPAANY IVAGGSRQLI 301QAAEQLKEAF EKAEPVAAGK E*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 750 shows 98.8% identity over a 321 aa overlap with a predicted ORF(ORF 750) from N. meningitidis:

a750/m750 98.8% identity in 321 aa overlap        10        20        30        40        50        60 a750.pepVKPRFYWAACAVLLTACSPEPAAEKTVSAASASAATLTVPTARGDAVVPKNPERVAVYDW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m750VKPRFYWAACAVLLTACSPEPAAEKTVSAASASAATLTVPTARGDAVVPKNPERVAVYDW        10        20        30        40        50        60        70        80        90       100       110       120 a750.pepAALDTLTELGVNVGATTAPVRVDYLQPAFDKAATVGTLFEPDYEALHRYNPQLVITGGPG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m750AALDTLTELGVNVGATTAPVRVDYLQPAFDKAATVGTLFEPDYEALHRYNPQLVITGGPG        70        80        90       100       110       120       130       140       150       160       170       180 a750.pepAEAYEQLAKNATTIDLTVDNGNIRTSGEKQMETLARIFGKEARAAELKAQIDALFAQTRE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m750AEAYEQLAKNATTIDLTVDNGNIRTSGEKQMETLARIFGKEARAAELKAQIDALFAQTRE       130       140       150       160       170       180       190       200       210       220       230       240 a750.pepAAKGKGRGLVLSVTGNKVSAFGTQSRLASWIHGDIGLPPVDESLRNEGHGQPVSFEYIKE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m750AAKGKGRGLVLSVTGNKVSAFGTQSRLASWIHGDIGLPPVDESLRNEGHGQPVSFEYIKE       190       200       210       220       230       240       250       260       270       280       290       300 a750.pepKNPDWIFIIDRTAAIGQEGPAAVEVLDNALVRGTNAWKRKQIIVMPAANYIVAGGSRQLI|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||| m750KNPDWIFIIDRTAAIGQEGPAAVEVLDNALVRGTNAWKRKQIIVMPAANYIVAGGARQLI       250       260       270       280       290       300       310       320 a750.pep QAAEQLKEAFEKAEPVAAGKEX |||||||||:|||||||||:| m750 QAAEQLKAAFKKAEPVAAGKKX        310       320

g751.seq not found yet

g751.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2579>:

m751.seq.. 1 ATGGCTTGGA GTATGTTTGC CACAACCCAA GCCGATAGAG CGGTAAGGTC 51TGCAACTGCA CCTAAAGAAA TGTGGTTCCA TAAGAAGATA ATAGATGAAA 101AAACAGGTAA AGTATCCTTT GATACCAGAC AAATTTGGTC ATTGAATGAT 151TTAAGCAAGG AAGAACTGGC AAGCATTCAA GACACAAATG GCAAAGTTAT 201TACTGTGTCT AATCCTGGTA TTTTCAATAA TCGAGAAGAT TCATTAAGCA 251ACGCAGCAAA ACAAAATCGT AATAGTACAA ACGGTAGTGG TGTTATTGCA 301GTCATGAATC CTCCAACAGG GAAATATAAA TCTGATTCTA ATAACAAAAT 351AAAAGATTTT TTATGGCTCG GTTCAAGTCT TGTTTCTGAA CTGATGTATG 401TCGGTTACGA CCAATTAAAT AATAAAGTGT TCCAAGGCTA TTTACCCAAA 451ACCAATTCAG AAAAACTGAA TCAAGATATT TATCGAGAGG TTCAAAAAAT 501GGGTAACGGC TGGTCGGTTG ATACCAGTAA TCACAGTCGT GGGGGAATTA 551CAGCAAGCGT TTCCTTAAAA GATTGGGTAA ACAATCAAAA ACAAAATGGC 601ATTGCCCCAA TCAGAAAAGC ACGTTTCTAT GGTACAGCCA CAAATGTGCA 651GAATGATTAC GCCGATGTTT TACAGAAAAA CGGCTATACC TATACGGGTG 701CAGACGGCAA AACTTATAAC AGCGGATCCT ACTCAATCGT GCATGATAAA 751GATTTTGTGG GGAACAAATG GATACCTTTC TTGCTAGGAA CCAATGACAC 801CACACAAGGT ACATGTAAGG GGTTGTGCTA TTCGCATAGC AGTTATTTTG 851CGGAGGTGCC AAAAGCAGGT ACAAAAGAAT TTGATGACTA TGTAAAAATA 901TGGGGTGAAG TTGAATATGA CGCTCAAGGT AAGCCAATTA ACAAATCTAA 951ACCCATACTG GTAGAACCAA ACAAAACAAA AGATAATGAA AAATATGAAA 1001AAGAAGCTTT CTAAThis corresponds to the amino acid sequence <SEQ ID 2580; ORF 751>:

m751.pep.. 1 MAWSMFATTQ ADRAVRSATA PKEMWFHKKI IDEKTGKVSF DTRQIWSLND 51LSKEELASIQ DTNGKVITVS NPGIFNNRED SLSNAAKQNR NSTNGSGVIA 101 VMNPPTGKYKSDSNNKIKDF LWLGSSLVSE LMYVGYDQLN NKVFQGYLPK 151 TNSEKLNQDI YREVQKMGNGWSVDTSNHSR GGITASVSLK DWVNNQKQNG 201 IAPIRKARFY GTATNVQNDY ADVLQKNGYTYTGADGKTYN SGSYSIVHDK 251 DFVGNKWIPF LLGTNDTTQG TCKGLCYSHS SYFAEVPKAGTKEFDDYVKI 301 WGEVEYDAQG KPINKSKPIL VEPNKTKDNE KYEKEA F *

a751.seq not found yet

a751.pep not found yet

g752.seq not found yet

g752.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2581>:

m752.seq.. 1 ATGAAAATTT CCAGACCTCC GGAATTTACC CTGTTGCAAC AGGAATATAT 51GCAGCATCTC ACTGAAAGAA TGACGCAAAT TGCCAAGCTG CTGAATTCTT 101 CCGCAAACAATCCTGATATA GACATTCCCG ATTTTCTTAC TGAAATCAAA 151 GATTATTCAG AATTTTCCGTGACAGATGAA AATGGAACCT ACCTGCATTG 201 GGACAAATTC CGCCGGATTC ACACGGAAGATACGCGGATG AAATGGCGCG 251 CCGTTAAGGA AAGCCGCAAA AAAATCCAAA AACCAATTGATTTCCCGTTT 301 GAACATCAGT TTTGGTTCTG CATTCCCGAC TCTTTGCAGG CACGGCTTCA351 TTTGATTGAC AAAAGCTGCG GCAGTTCTAT CGGCACGTCT AGCTTGGGTG 401GCTTCGGCAG AAGCGAGCAA AACAGATTCT TGCTCAAGTC TCTGATTATG 451 GAAGAAGCGATTACATCCGC CCAACTGGAA GGTGCGGCTA CCACGCGTAA 501 AGTGGCCAAG GATATGCTCAAATCGCAGCG TAAACCCAAA ACAAAAGACG 551 AAATCATGAT AGTGAACAAC TATCACTTGATGAAAAAAGC GGTAGAATTG 601 AAAAATACGC CGTTAAGTGT TGAAATGATT TTGGATTTGCACCGCATTGC 651 TACCAGTAAC GCTATTGAAA ACAAGGCCGA GCCCGGACAA TTCAGGCAGG701 ATGACGAAAT CTTTATCGCC GATATCAATG GTAACAGCCT GTATCAACCA 751CCGCCGCACG GACAGGTTCA TACGCTGATG GAAGAGGTGT GTGCGTTTGC 801 CAATAATACCTATGACGGCG TGGAAAATCC GTTTATCCAT CCGGTTGTCC 851 AAGCTATTAT CTTGCATTTCCTCATCGGCT ACATCCACCC ATTTGGTGAT 901 GGCAACGGGC GGACAGCGCG GGCTTTGTTCTATTGGTTTA TGCTCAAAAA 951 CGGCTACTGG CTATTTGAAT ACATATCCAT CAGCCGTCTTCTGAAAAACG 1001 CTCCTGCCCA ATACGCCAAA TCCTATTTGT ATGCGGAAAC TGACGATTTA1051 GATTTAACCT ATTTCATCTA TTACCAATGC GATATTATCA AGCGGGCGGT 1101TGCCGATTTG GAGCACTACA TTTCCGACAA ACAAAAACAC CAACAGGAAT 1151 TCAAAGCAGCGATTGCCCAA TATACTGAAA AGATAGGAAA GTTGAACCAA 1201 CGGCAAATTG GTATCCTGCAAAAAGCAGTG GAAGAAAGCG GAAAAATCTT 1251 TACTGCACAA GAAATTGCCA ACCAATACGGCATCTCCCTG AATACTGCCC 1301 GTAGCGATTT GAGTAAACTG GGAGAATATA GATTCCTAGTGCCGTTCAAA 1351 TCAGGAAATG CTTTAGAGTA TGTTGCTCCT CAGGATTTAT TGGAAAGGTT1401 AGAAAAAAAA TAGThis corresponds to the amino acid sequence <SEQ ID 2582; ORF 752>:

m752.pep 1 MKISRPPEFT LLQQEYMQHL TERMTQIAKL LNSSANNPDI DIPDFLTEIK 51DYSEFSVTDE NGTYLHWDKF RRIHTEDTRM KWRAVKESRK KIQKPIDFPF 101 EHQFWFCIPDSLQARLHLID KSCGSSIGTS SLGGFGRSEQ NRFLLKSLIM 151 EEAITSAQLE GAATTRKVAKDMLKSQRKPK TKDEIMIVNN YHLMKKAVEL 201 KNTPLSVEMI LDLHRIATSN AIENKAEPGQFRQDDEIFIA DINGNSLYQP 251 PPHGQVHTLM EEVCAFANNTYDGVENPFIH PVVQAIILHF LIGYIHPFGD 301 GNGRTARALF YWFMLKNGYW LFEYISISRLLKNAPAQYAK SYLYAETDDL 351 DLTYFIYYQC DIIKRAVADL EHYISDKQKH QQEFKAAIAQYTEKIGKLNQ 401 RQIGILQKAV EESGKIFTAQ EIANQYGISL NTARSDLSKL GEYRFLVPFK451 SGNALEYVAP QDLLERLEKK *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2583>:

m752-1.seq 1 ATGAAAATTT CCAGACCTCC GGAATTTACC CTGTTGCAAC AGGAATATAT 51GCAGCATCTC ACTGAAAGAA TGACGCAAAT TGCCAAGCTG CTGAATTCTT 101 CCGCAAACAATCCTGATATA GACATTCCCG ATTTTCTTAC TGAAATCAAA 151 GATTATTCAG AATTTTCCGTGACAGATGAA AATGGAACCT ACCTGCATTG 201 GGACAAATTC CGCCGGATTC ACACGGAAGATACGCGGATG AAATGGCGCG 251 CCGTTAAGGA AAGCCGCAAA AAAATCCAAA AACCAATTGATTTCCCGTTT 301 GAACATCAGT TTTGGTTCTG CATTCCCGAC TCTTTGCAGG CACGGCTTCA351 TTTGATTGAC AAAAGCTGCG GCAGTTCTAT CGGCACGTCT AGCTTGGGTG 401GCTTCGGCAG AAGCGAGCAA AACAGATTCT TGCTCAAGTC TCTGATTATG 451 GAAGAAGCGATTACATCCGC CCAACTGGAA GGTGCGGCTA CCACGCGTAA 501 AGTGGCCAAG GATATGCTCAAATCGCAGCG TAAACCCAAA ACAAAAGACG 551 AAATCATGAT AGTGAACAAC TATCACTTGATGAAAAAAGC GGTAGAATTG 601 AAAAATACGC CGTTAAGTGT TGAAATGATT TTGGATTTGCACCGCATTGC 651 TACCAGTAAC GCTATTGAAA ACAAGGCCGA GCCCGGACAA TTCAGGCAGG701 ATGACGAAAT CTTTATCGCC GATATCAATG GTAACAGCCT GTATCAACCA 751CCGCCGCACG GACAGGTTCA TACGCTGATG GAAGAGGTGT GTGCGTTTGC 801 CAATAATACCTATGACGGCG TGGAAAATCC GTTTATCCAT CCGGTTGTCC 851 AAGCTATTAT CTTGCATTTCCTCATCGGCT ACATCCACCC ATTTGGTGAT 901 GGCAACGGGC GGACAGCGCG GGCTTTGTTCTATTGGTTTA TGCTCAAAAA 951 CGGCTACTGG CTATTTGAAT ACATATCCAT CAGCCGTCTTCTGAAAAACG 1001 CTCCTGCCCA ATACGCCAAA TCCTATTTGT ATGCGGAAAC TGACGATTTA1051 GATTTAACCT ATTTCATCTA TTACCAATGC GATATTATCA AGCGGGCGGT 1101TGCCGATTTG GAGCACTACA TTTCCGACAA ACAAAAACAC CAACAGGAAT 1151 TCAAAGCAGCGATTGCCCAA TATACTGAAA AGATAGGAAA GTTGAACCAA 1201 CGGCAAATTG GTATCCTGCAAAAAGCAGTG GAAGAAAGCG GAAAAATCTT 1251 TACTGCACAA GAAATTGCCA ACCAATACGGCATCTCCCTG AATACTGCCC 1301 GTAGCGATTT GAGTAAACTG GGAGAATATA GATTCCTAGTGCCGTTCAAA 1351 TCAGGAAATG CTTTAGAGTA TGTTGCTCCT CAGGATTTAT TGGAAAGGTT1401 AGAAAAAAAA TAGThis corresponds to the amino acid sequence <SEQ ID 2584; ORF 752-1>:

m752-1.pep 1 MKISRPPEFT LLQQEYMQHL TERMTQIAKL LNSSANNPDI DIPDFLTEIK 51DYSEFSVTDE NGTYLHWDKF RRIHTEDTRM KWRAVKESRK KIQKPIDFPF 101 EHQFWFCIPDSLQARLHLID KSCGSSIGTS SLGGFGRSEQ NRFLLKSLIM 151 EEAITSAQLE GAATTRKVAKDMLKSQRKPK TKDEIMIVNN YHLMKKAVEL 201 KNTPLSVEMI LDLHRIATSN AIENKAEPGQFRQDDEIFIA DINGNSLYQP 251 PPHGQVHTLM EEVCAFANNTYDGVENPFIH PVVQAIILHF LIGYIHPFGD 301 GNGRTARALF YWFMLKNGYW LFEYISISRLLKNAPAQYAK SYLYAETDDL 351 DLTYFIYYQC DIIKRAVADL EHYISDKQKH QQEFKAAIAQYTEKIGKLNQ 401 RQIGILQKAV EESGKIFTAQ EIANQYGISL NTARSDLSKL GEYRFLVPFK451 SGNALEYVAP QDLLERLEKK *

a752.seq not found yet

a752.pep not found yet

g753.seq not found yet

g753.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2585>:

m753.seq 1 ATGCCCATCA CTCCACCCTT AAACATCATC TCTCCTAAAC TCTACCCCAA 51TGAACAATGG AACGAAAGCG AAGCACTCGG TGCCATCACT TGGCTATGGT 101 ATCAGTCGCCTACGCATCGC CAAGTACCTA TTGTGGAGAT GATGACGTAT 151 ATATTGCCTG TGTTAAAAAACGGGCAGTTC GCTTTGTTTT GCAAGGGTAC 201 CCAACCAATC GGTTATATCT CATGGGCTTATTTTGATGAA GTGGCGCAGG 251 CGCATTATTT AGAATCTGAC CGCCATTTGC GTGACAACAGCGATTGGAAC 301 TGTGGCGACA ATATTTGGCT GATTCAATGG TTTGCGCCAT TGGGACACAG351 TCATCAAATG CGCTCAGCTG TGCGCCAGTT ATTTCCTAGT ACGACAGTAC 401GCGCCTTGTA TCATAAAGGG AGCGATAAGG GTTTGAGAAT TTTAACTTTT 451 AAAACTTGAThis corresponds to the amino acid sequence <SEQ ID 2586; ORF 753>:

m753.pep 1 MPITPPLNII SPKLYPNEQW NESEALGAIT WLWYQSPTHR QVPIVEMMTY 51ILPVLKNGQF ALFCKGTQPI GYISWAYFDE VAQAHYLESD RHLRDNSDWN 101 CGDNIWLIQWFAPLGHSHQM RSAVRQLFPS TTVRALYHKG SDKGLRILTF 151 KT*

a753.seq not found yet

a753.pep not found yet

g754.seq not found yet

g754.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2587>:

m754.seq 1 ATGATGAAGT CTATCCTCAC CGTATCCGGA AATCGTATGC GTAAACCCAG 51AATCACCTAT TTGGATGTTT GGGCAAACGA TGAAAGAATC GGTACTTTGG 101 AAAAGGGGGCCATGTATCGG TTCGCATACG ACAATCCCAA TTCTTCGTTG 151 CTGGGCCTGC ATTATCAAGACAGAAGCAAG GTATATATCA GCAACAATAT 201 GCCGCATATC TTTGCACAGT ATTTTCCGGAAGGCTTTTTG GATGCACACA 251 TCACAAGCAA ATATGCTTTT CATGATGCGC CTTTTGAAGACAATGAGATG 301 CTGCGCTTGG CAATTCTGTG CAGAGAGACT TTGGGTCGGA TACATGTGCG351 CTGTAATGAC CCGCTTTTTA ATGAATGGAT TGACGGGTTG GAGATGAAAA 401ATCCAAGAAT ATTGACTGAA CGGGATTTGC TGGGCATAAA TGCCCGACAG 451 GTTTTTCAGCAATATATGGC AGAAATCTTC CATCACGGCC GTTTCGTCAG 501 TGTATCCGGG ATACAGCAGAAGATGTCCTT AGATGCCATC CGCAGAAATA 551 CCAAGCAAAC TGCCTCATAT ATTGCCAAAGGTTTTGATGC ATCCGAATAT 601 CCTTGCTTGG CTGCCAATGA ATTTTTATGC ATGCAGACCATCAAACAAGC 651 CGGCATTGCC GTTGCACAGA CCAGCCTGTC GGAAGATTCA TCAGTCTTAT701 TGGTACGTCG GTTTGATGTC AGTGAACAGG GTTATTTTTT AGGGATGGAA 751GACTTTACCA GTCTGCGCCA GTATTCGGTA GAAGATAAAT ATAAAGGCAG 801 TTATGCGGCTATTGCACAGA TTATCCGACA GATATCCGGC AGACCAGATG 851 AAGATTTAAT CCATTTCTTTAATCAGCTTG CTGCCAGTTG CATATTGAAA 901 AACGGCGATG CACACCTCAA AAATTTTTCAGTACTCTATC ATGACGAATA 951 CGATGTTCGT CTTGCACCTG TCTATGATGT ATTGGATACATCAATATACA 1001 GGGTTGGAAC ACAAGGAATT TTTGATGCTT ATGACGATAC GCTGGCATTA1051 AACCTGACTA ACCACGGTAA GAAAACATAT CCTTCCAAGA ATACATTGTT 1101GGATTTTGCT GAGAAATATT GCGATTTGGG AAGAGAAGAT GCATCCTTTA 1151 TGATAGATACAATCGTTCAA GCTAAAGAAC AGGTTCTTGT TAAATACTCG 1201 GATGTATTGC GTGAGAATGAATGGTTGGCG CAGAAGTGGC ATTTTATCCC 1251 GGATGAAAAT GAAGAAGGTC TACCGTTTACATTCCGGTAGThis corresponds to the amino acid sequence <SEQ ID 2588; ORF 754>:

m754.pep 1 MMKSILTVSG NRMRKPRITY LDVWANDERI GTLEKGAMYR FAYDNPNSSL 51LGLHYQDRSK VYISNNMPHI FAQYFPEGFL DAHITSKYAF HDAPFEDNEM 101 LRLAILCRETLGRIHVRCND PLFNEWIDGL EMKNPRILTE RDLLGINARQ 151 VFQQYMAEIF HHGRFVSVSGIQQKMSLDAI RRNTKQTASY IAKGFDASEY 201 PCLAANEFLC MQTIKQAGIA VAQTSLSEDSSVLLVRRFDV SEQGYFLGME 251 DFTSLRQYSV EDKYKGSYAA IAQIIRQISG RPDEDLIHFFNQLAASCILK 301 NGDAHLKNFS VLYHDEYDVR LAPVYDVLDT SIYRVGTQGI FDAYDDTLAL351 NLTNHGKKTY PSKNTLLDFA EKYCDLGRED ASFMIDTIVQ AKEQVLVKYS 401DVLRENEWLA QKWHFIPDEN EEGLPFTFR*

a754.seq not found yet

a754.pep not found yet

g755.seq not found yet

g755.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2589>:

m755.seq.. 1 ATGAGCCGTT ACCTGATTAC CTTTGATATG GATACCAACT GCCTGAAAGA 51CAATTACCAC GGAAATAACT ATACCAATGC CTACTCCGAT ATTAAAACCA 101 TCTTGGCTAGACATGGATTT GAGAACATTC AGGGCAGTGT TTATCTAGGC 151 CGTGAAGGCA TCAGTGAAGCACACGGAACA ATAGCCATTC AGGAACTGAC 201 CGCTCGGTTT GATTGGTTTT ACTCCTGTATTTCAAACATT AAGTTTTACC 251 GCCTTGAAAG TGATTTGAAC GCACAATTTA TCGCTGATGGTGTGTATCAA 301 GCCAAACAGG CTTTCCTTCA ACGTGTTGAA CAACTTCGTA TATCCCTAAC351 AGAAGCTGGA TTGTCTGATG AGCAAATCAA TCAGGTTCTG GAAAAACAGA 401AATTTGAATT GGAAAGTCCT AACCTGAAAT TAAATTAAThis corresponds to the amino acid sequence <SEQ ID 2590; ORF 755>:

m755.pep.. 1 MSRYLITFDM DTNCLKDNYH GNNYTNAYSD IKTILARHGF ENIQGSVYLG 51REGISEAHGT IAIQELTARF DWFYSCISNI KFYRLESDLN AQFIADGVYQ 101 AKQAFLQRVEQLRISLTEAG LSDEQINQVL EKQKFELESP NLKLN*

a755.seq not found yet

a755.pep not found yet

g756.seq not found yet

g756.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2591>:

m756.seq 1 ATGACCGCCA ACTTTGCACA GACGCTGGTC GAAATACAGG ACAGTCTGTA 51CAGGGTTGTG TCAACCGTCC AATACGGGGA TGACAACCTC AAGCGGTTGA 101 CAGCGGACAAACGGAAGCAG TATGAGTTGA ACTTCAAGAT TTCCGAGGGT 151 TCTACGCGTG TAGAGTCCGACTTTAAAGAG ACTTTGGTTC GGTTCGGTAG 201 AGATATGCTT CAAGATATGC CCCCTAAAATCCGTTCGGCA ACGCTGGTAG 251 CGTTGACGAC CCTGCTTGTC GGAGGGGCGT TGGGTTACGGTTATTTGGAA 301 TACCTGAAGC AGGTTGCTTC GGAAGGGTAT CAGACCGAGC GTCTGTATAA351 TGCCGTCGAC CGTCTTGCAG AATCCCAAGA ACGGATAACG TCCGCCATCC 401TGAAGGGTGC TAGAGGTGCC GATTTCGTGC AAATCGGCAG ACGTTCCTAC 451 AGTAGGGAGGATATATCGGA GGCAAATAGA CGTGCAGAGC GTGTCCCGTA 501 TGGCGCAGAG TTGGTTTCAGACGGCAATTT TACCGCTGTT TTATCTGATA 551 TAGGGGATTA AThis corresponds to the amino acid sequence <SEQ ID 2592; ORF 756>:

m756.pep 1 MTANFAQTLV EIQDSLYRVV STVQYGDDNL KRLTADKRKQ YELNFKISEG 51STRVESDFKE TLVRFGRDML QDMPPKIRSA TLVALTTLLV GGALGYGYLE 101 YLKQVASEGYQTERLYNAVD RLAESQERIT SAILKGARGA DFVQIGRRSY 151 SREDISEANR RAERVPYGAELVSDGNFTAV LSDIGD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2593>:

a756.seq 1 ATGACCGCCA ACTTTGCACA GACGCTGGTC GAAATACAGG ACAGTCTGTA 51NAGGGTTGTG TCAACCGTCC AATACGGGGA TGACAACCTC AAGCGGTTGA 101 CAGCGGACAAACGGAAGCAG TATGAGTTGA ACTTCAAGAT TTCCGAGGGT 151 TCTACGCGTG TAGAGTCCGACTTTAAAGAG ACTTTGGTTC GGTTCGGTAG 201 AGATATGCTT CAAGATATGC CCCCTAAAATCCGTTCGGCA ACGCTGGTAG 251 CGTTGACGAC CCTGCTTGTC GGAGGGGCGT TGGGTTACGGTTATTTGGAA 301 TACCTGAAGC AGGTTGCTTC GGAAGGGTAT CAGACCGAGC GTCTGTATAA351 TGCCGTCGAC CGTCTTGCAG AATCCCAAGA ACGGATAACG TCCGCCATCC 401TGAAGGGTGC TAGAGGTGCC GATTTCGTGC AAATCGGCAG ACGTTCCTAC 451 AGTAGGGAGGATATATCGGA GGCAAATAGA CGTGCAGAGC GTGTCCCGTA 501 TGGCGCAGAG TTGGTTTCAGACGGCAATTT TACCGCTGTT TTATCTGATA 551 TAGGGGATTA AThis corresponds to the amino acid sequence <SEQ ID 2594; ORF 756.a>:

a756.pep 1 MTANFAQTLV EIQDSLXRVV STVQYGDDNL KRLTADKRKQ YELNFKISEG 51STRVESDFKE TLVRFGRDML QDMPPKIRSA TLVALTTLLV GGALGYGYLE 101 YLKQVASEGYQTERLYNAVD RLAESQERIT SAILKGARGA DFVQIGRRSY 151 SREDISEANR RAERVPYGAELVSDGNFTAV LSDIGD* m756/a756 99.5% identity in 186 aa overlap        10        20        30        40        50        60 m756.pepMTANFAQTLVEIQDSLYRVVSTVQYGDDNLKRLTADKRKQYELNFKISEGSTRVESDFKE|||||||||||||||| ||||||||||||||||||||||||||||||||||||||||||| a756MTANFAQTLVEIQDSLXRVVSTVQYGDDNLKRLTADKRKQYELNFKISEGSTRVESDFKE        10        20        30        40        50        60        70        80        90       100       110       120 m756.pepTLVRFGRDMLQDMPPKIRSATLVALTTLLVGGALGYGYLEYLKQVASEGYQTERLYNAVD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a756TLVRFGRDMLQDMPPKIRSATLVALTTLLVGGALGYGYLEYLKQVASEGYQTERLYNAVD        70        80        90       100       110       120       130       140       150       160       170       180 m756.pepRLAESQERITSAILKGARGADFVQIGRRSYSREDISEANRRAERVPYGAELVSDGNFTAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a756RLAESQERITSAILKGARGADFVQIGRRSYSREDISEANRRAERVPYGAELVSDGNFTAV       130       140       150       160       170       180 m756.pepLSDIGDX ||||||| a756 LSDIGDX

g757.seq not found yet

g757.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2595>:

m757.seq 1 ATGAAAATAC TCGCTTTATT AATTGCCGCT ACCTGTGCTT TATCTGCGTG 51TGGCAGCCAA TCTGAAGAAC AACCGGCATC TGCACAACCC CAAGAGCAGG 101 CACAATCCGAATTAAAAACC ATGCCGGTAA GCTATACCGA CTATCAATCA 151 GCAGCCAATA AAGGGCTGAATGACCAAAAA ACCGGTCTGA CCCTTCCTGA 201 ACATGTTGTC CCTATCGACA ATGCGGAAGGAAAGAATCTG CTGCATGACT 251 TTTCAGACGG CCTCACAATC TTAACCGTTG ATACCGATAAAGCCGACAAA 301 ATTACTGCTG TCCGAGTAGT CTGGAATACA GATGCAATGC CTCAAAAAGC351 GGAAAAACTG TCCAAAGCTG CCGCAGCCTT GATTGCGGCA ACCGCTCCGG 401AAGACCGCAC AATGCTGCGT GATACCGGCG ACCAAATCGA AATGGCGATT 451 GACAGCCATAATGCGCAAAA AGAGCCAACC CGAGAATGGG CGCGTGGTGG 501 GATTGCTTAT AAAGTCACTGTTACCAATTT ACCGAGCGTG GTTTTGACGG 551 CAAAAGCTGA GTAAThis corresponds to the amino acid sequence <SEQ ID 2596; ORF 757>:

m757.pep (lipoprotein) 1 MKILALLIAA TCALSACGSQ SEEQPASAQP QEQAQSELKTMPVSYTDYQS 51 AANKGLNDQK TGLTLPEHVV PIDNAEGKNL LHDFSDGLTI LTVDTDKADK 101ITAVRVVWNT DAMPQKAEKL SKAAAALIAA TAPEDRTMLR DTGDQIEMAI 151 DSHNAQKEPTREWARGGIAY KVTVTNLPSV VLTAKAE*

a757.seq not found yet

a757.pep not found yet

g758.seq not found yet

g758.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2597>:

m758.seq 1 ATGAACAATC TGACCGTGTT TACCCGTTTC GATACCGATT TGGCGACGCT 51TGCCGATGAA TTGCAATATG TGTGGGAACA CACCGCCGTT ACAGACCATC 101 AGGGCAAACTGGTGGAAATT CCCGTCTGCT ACGGCGGCGA ATACGGCCCG 151 GATTTGGCGG AAGTCGCTGCTTTCCATCAG ACGGTTATTT CCGAAATCGT 201 CCGCCGCCAT ACGGCGCAAA CTTATACCGTATTTATGATG GGCTTCCAGC 251 CCGGTTTCCC TTATCTGGGC GGCTTGCCCG AAGCATTGCACACGCCCCGC 301 CGTGCCGTGC CGAGAACGTC CGTTCCTGCC GGTTCGGTCG GTATCGGCGG351 CAGTCAGACC GGTGTGTATC CGTTCGCTTC GCCCGGCGGC TGGCAGATTA 401TCGGCAGAAC CGAATTACCC TTGTTCCGAG CCGATTTGAA TCCGCCGACC 451 CTGCTGGCGGCGGGTGACCA AGTCCGCTTT GTTGCAGAAA GGATTGAGCC 501 ATGAThis corresponds to the amino acid sequence <SEQ ID 2598; ORF 758>:

m758.pep 1 MNNLTVFTRF DTDLATLADE LQYVWEHTAV TDHQGKLVEI PVCYGGEYGP 51DLAEVAAFHQ TVISEIVRRH TAQTYTVFMM GFQPGFPYLG GLPEALHTPR 101RAVPRTSVPA GSVGIGGSQT GVYPFASPGG WQIIGRTELP LFRADLNPPT 151 LLAAGDQVRFVAERIEP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2599>:

a758.seq 1 ATGAACAATC TGACCGTGTT CACCCGTTTC GATACCGATT TGGCGACGCT 51TGCCGATGAA TTGCAATATG TGTGGGAACA CACCGCCGTT ACAGACCATC 101 AGGGCAAACTGGTGGAAATT CCCGTCTGCT ACGGCGGCGA ATACGGCCCG 151 GATTTGGCGG AAGTCGCTGCTTTCCATCAG ACGGTTATTT CCGAAATCGT 201 CCGCCGCCAT ACGGCGCAAA CTTATACCGTATTTATGATG GGCTTCCAGC 251 CTGGTTTCCC TTATCTGGGC GGCTTGCCCG AAGCATTGCACACGCCCCGC 301 CGTGCCGTGC CGAGAACGTC CGTTCCTGCC GGTTCGGTCG GTATCGGCGG351 CAGTCAGACC GGTGTGTATC CGTTCGCTTC GCCCGGCGGC TGGCAGATTA 401TCGGCAGAAC CGAATTACCC TTGTTCCGAG CCGATTTGAA TCCGCCGACC 451 CTGCTGGCGGCGGGTGACCA AGTCCGCTTT GTTGCAGAAA GGATTGAGCC 501 ATGAThis corresponds to the amino acid sequence <SEQ ID 2600; ORF 758.a>:

a758.pep.. 1 MNNLTVFTRF DTDLATLADE LQYVWEHTAV TDHQGKLVEI PVCYGGEYGP 51DLAEVAAFHQ TVISEIVRRH TAQTYTVFMM GFQPGFPYLG GLPEALHTPR 101RAVPRTSVPA GSVGIGGSQT GVYPFASPGG WQIIGRTELP LFRADLNPPT 151 LLAAGDQVRFVAERIEP* m758/a758 100.0% identity in 167 aa overlap        10        20        30        40        50        60 m758.pepMNNLTVFTRFDTDLATLADELQYVWEHTAVTDHQGKLVEIPVCYGGEYGPDLAEVAAFHQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a758MNNLTVFTRFDTDLATLADELQYVWEHTAVTDHQGKLVEIPVCYGGEYGPDLAEVAAFHQ        10        20        30        40        50        60        70        80        90       100       110       120 m758.pepTVISEIVRRHTAQTYTVFMMGFQPGFPYLGGLPEALHTPRRAVPRTSVPAGSVGIGGSQT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a758TVISEIVRRHTAQTYTVFMMGFQPGFPYLGGLPEALHTPRRAVPRTSVPAGSVGIGGSQT        70        80        90       100       110       120       130       140       150       160 m758.pepGVYPFASPGGWQIIGRTELPLFRADLNPPTLLAAGDQVRFVAERIEPX|||||||||||||||||||||||||||||||||||||||||||||||| a758GVYPFASPGGWQIIGRTELPLFRADLNPPTLLAAGDQVRFVAERIEPX       130       140       150       160

g759.seq not found yet

g759.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2601>:

m759.seq 1 ATGCGCTTCA CACACACCAC CCCATTTTGT TCCGTATTGT CCACCCTCGG 51TCTTTTTGCC GTTTCCCCTG CTTACTCATC CATTGTCCGC AACGATGTCG 101 ATTACCAATATTTTCGCGAC TTTGCCGAAA ATAAAGGCGC GTTCACCGTA 151 GGTGCAAGCA ATATTTCCATCCAAGACAAG CAAGGCAAAA TATTAGGCAG 201 GGTTCTCAAC GGCATCCCCA TGCCCGACTTCCGCGTCAGC AACCGCCAAA 251 CCGCCATCGC CACCCTGGTT CACCCCCAAT ACGTCAACAGTGTCAAACAC 301 AACGTCGGCT ACGGTTCCAT ACAATTCGGC AACGACACCC AAAATCCAGA351 AGAACAAGCC TATACCTACC GCCTCGTATC ACGCAACCCG CACCCGGACT 401ACGACTACCA CCTTCCCCGC CTCAACAAAC TGGTTACCGA AATCTCACCT 451 ACCGCACTCAGCAGCGTACC CTTGCTTGGA AACGGCCAGC CAAAGGCCAA 501 TGCCTACCTC GATACCGACCGCTTCCCCTA CTTTGTACGA CTCGGCTCAG 551 GCACGCAACA AGTCCGCAAA GCAGACGGCACGCGTACACG AACCGCCCCG 601 GCATACCAAT ACCTGACCGG CGGCACGCCG CTGAAAGTATTGGGGTTCCA 651 AAACCACGGC TTACTCGTCG GCGGCAGCCT GACCGACCAA CCCCTTAACA701 CCTACGCAAT CGCCGGAGAC AGCGGTTCCC CCCTGTTTGC CTTCGACAAG 751CATGAAAACC GCTGGGTGCT TGCGGGCGTA CTCAGCACCT ACGCCGGCTT 801 CGATAATTTCTTCAACAAAT ACATCGTCAC GCAACCCGAA TTCATCCGTT 851 CCACCATCCG CCAATACGAAACCCGGCTGG ATGTCGGGCT GACCACCAAC 901 GAACTCATAT GGCGCGACAA CGGTAATGGCAACAGCACCC TGCAAGGGCT 951 CAACGAACGC ATCACCCTGC CCATTGCAAA CCCTTCGCTTGCCCCACAAA 1001 ACGACAGCAG GCACATGCCG TCTGAAGATG CCGGCAAAAC GCTCATCCTA1051 TCCAGCAGGT TCGACAACAA AACACTGATG CTGGCAGACA ATATCAACCA 1101AGGCGCAGGC GCATTGCAGT TCGACAGCAA CTTCACCGTC GTCGGTAAAA 1151 ACCACACATGGCAAGGTGCA GGCGTTATCG TAGCCGACGG CAAACGCGTC 1201 TTCTGGCAAG TCAGCAACCCCAAAGGCGAC CGGCTCTCCA AACTGGGCGC 1251 AGGCACGCTT ATCGCCAACG GACAAGGCATCAACCAGGGC GACATCAGCA 1301 TCGGGGAAGG CACTGTCGTA CTCGCCCAAA AAGCTGCTTCAGACGGCAGC 1351 AAACAAGCAT TCAACCAAGT CGGCATCACC AGCGGCAGGG GCACGGCCGT1401 CCTCGCCGAC AGCCAGCAAA TCAAACCCGA AAACCTCTAT TTCGGCTTCA 1451GGGGCGGACG GCTCGACCTC AACGGCAACA ACCTTGCCTT TACCCATATC 1501 CGCCATGCGGACGGCGGCGC GCAAATCGTC AATCACAACC CTGACCAAGC 1551 CGCGACACTG ACGCTGACCGGCAACCCCGT CCTCAGTCCC GAGCATGTCG 1601 AGTGGGTGCA ATGGGGCAAC CGTCCGCAAGGCAACGCGGC GGTTTACGAA 1651 TACATCAACC CGCACCGCAA CCGTCGGACC GACTACTTCATACTCAAACC 1701 CGGCGGCAAC CCGCGCGAAT TTTTCCCGTT AAATATGAAA AACTCAACAA1751 GCTGGCAATT TATCGGCAAC AACAGGCAAC AGGCCGCCGA ACAAGTCGCC 1801CAAGCCGAAA ATGCCCGCCC CGACCTGATT ACCTTCGGCG GATACTTGGG 1851 TGAAAACGCGCAAACGGGCA AAGCCGCGCC GAGTTACAGC AAAACCAATG 1901 AAGCAGCCAT AGAAAAAACCCGCCATATCG CAAATGCCGC CGTATACGGC 1951 CGGCCCGAAT ACCGTTACAA CGGCGCACTCAACCTGCACT ATCGTCCCAA 2001 ACGCACCGAC AGCACGCTGT TGCTCAACGG CGGCATGAACCTTAACGGGG 2051 AAGTCTTGAT TGAGGGCGGC AATATGATTG TGTCAGGCAG GCCCGTACCC2101 CATGCCTACG ACCACCAGGC CAAACGCGAA CCCGTTCTTG AAAACGAATG 2151GACCGACGGC AGCTTCAAGG CTGCACGGTT CACCCTGCGA AACCATGCCC 2201 GACTGACGGCAGGGCGCAAT ACCGCGCATC TGGACGGCGA CATAACCGCA 2251 TACGATCTGT CCGGCATCGACCTCGGCTTT ACCCAAGGCA AAACACCGGA 2301 ATGCTACCGC TCCTACCATA GCGGCAGCACCCACTGCACA CCCAACGCCG 2351 TTTTAAAAGC CGAAAACTAT CGTGCACTAC CTGCAACGCAAGTACGCGGC 2401 GACATTACCC TTAACGACCG TTCAGAGCTC CGCCTGGGCA AAGCACACCT2451 GTACGGCAGC ATCCGTGCCG GCAAAGACAC CGCAGTCCGC ATGGAAGCAG 2501ACAGCAACTG GACACTTTCC CAGTCCAGCC ACACCGGCGC ACTGACGCTT 2551 GACGGCGCACAAATTACCCT GAACCCCGAT TTCGCCAATA ATACACACAA 2601 CAACCGCTTC AACACACTGACCGTCAACGG CACACTTGAC GGGTTCGGCA 2651 CATTCCGATT CCTGACCGGC ATCGTCCGAAAACAAAATGC CCCCCCCCTC 2701 AAACTGGAAG GGGACAGCCG CGGCGCATTC CAAATCCACGTCAAAAACAC 2751 CGGACAAGAA CCTCAAACAA CCGAATCGCT TGCACTTGTG AGCCTCAATC2801 CGAAACACAG CCACCAAGCC CGATTCACCC TCCAAAACGG CTATGCCGAT 2851TTGGGTGCCT ACCGCTACAT CCTCCGCAAA AACAACAACG GATACAGCCT 2901 GTACAACCCGCTCAAAGAGG CCGAACTTCA AATTGAAGCC ACGCGTGCGG 2951 AACATGAGCG CAACCAACAGGCATACAACC AATTACAGGC AACCGACATC 3001 AGCAGACAGG TTCAACATGA CTCTGACGCGACCAGGCAGG CACTACAGGC 3051 CTGGCAGAAC AGTCAAACCG AACTTGCCCG CATCGACAGCCAAGTCCAAT 3101 ATCTGTCCGC CCAATTGAAA CAGACAGACC CGCTGACCGG CATTCTGACG3151 CGTGCCCAAA ACCTGTGTGC CGCACAAGGA TACAGTGCCG ATATCTGCCG 3201TCAGGTTGCC AAAGCCGCCG ACACGAACGA CCTGACACTC TTCGAAACCG 3251 AACTGGATACGTATATAGAA CGTGTAGAAA TGGCCGAATC CGAACTTGAC 3301 AAAGCACGGC AAGGCGGCGATGCGCAAGCC GTCGAAACAG CCCGGCACGC 3351 CTACCTGAAC GCACTCAACC GTCTGTCCCGACAAATCCAC AGTTTGAAAA 3401 CCGGCGTTGC CGGCATCCGT ATGCCGAACC TGGCCGAACTGATCAGCCGG 3451 TCGGCCAACA CCGCCGTTTC CGAACAGGCC GCCTACAATA CCGGCCGGCA3501 ACAGGCGGGA CGCCGCATCG ACCGCCACCT TACCGATCCG CAGCAGCAAA 3551ACATCTGGCT GGAAACCGGT ACGCAACAAA CCGACTACCA TAGCGGCACA 3601 CACCGTCCCTACCAACAAAC TACCAACTAT GCACATATCG GCATCCAAAC 3651 CGGCATCACC GACCGTCTCAGTGTCGGTAC GATTTTAACC GATGAGCGCA 3701 CAAACAACCG TTTTGATGAA GGCGTATCCGCCCGAAACCG CAGCAACGGC 3751 GCACATCTGT TCGTCAAAGG GGAAAACGGC GCACTCTTTGCCGCGGCAGA 3801 TTTAGGCTAC AGCAACAGCC GTACCCGATT TACCGATTAT GACGGGGCTG3851 CCGTCCGCCG CCACGCATGG GATGCAGGCA TCAACACCGG CATCAAAATC 3901GATACCGGCA TCAACCTCAG ACCCTATGCC GGCATCCGTA TAAACCGCAG 3951 CAACGGCAACCGGTACGTAC TCGACGGCGC AGAGATAAAC AGCCCGGCGC 4001 AAATCCAAAC CACATGGCATGCCGGCATCC GTCTCGATAA AACCGTCGAA 4051 CTGGGTCAAG CCAAGCTGAC CCCCGCCTTCAGCAGCGATT ACTACCATAC 4101 CCGCCAAAAC AGCGGTTCCG CCCTCAGCGT CAACGACCGTACCTTACTGC 4151 AGCAAGCCGC CCACGGCACA CTGCATACCC TGCAAATCGA CGCCGGATAC4201 AAAGGCTGGA ACGCCAAACT TCATGCCGCT TACGGCAAAG ACAGCAACAC 4251CGCCCGCCAC AAACAGGCAG GAATCAAAAT AGGCTACAAC TGGTAAThis corresponds to the amino acid sequence <SEQ ID 2602; ORF 759>:

m759.pep 1 MRFTHTTPFC SVLSTLGLFA VSPAYSSIVR NDVDYQYFRD FAENKGAFTV 51GASNISIQDK QGKILGRVLN GIPMPDFRVS NRQTAIATLV HPQYVNSVKH 101 NVGYGSIQFGNDTQNPEEQA YTYRLVSRNP HPDYDYHLPR LNKLVTEISP 151 TALSSVPLLG NGQPKANAYLDTDRFPYFVR LGSGTQQVRK ADGTRTRTAP 201 AYQYLTGGTP LKVLGFQNHG LLVGGSLTDQPLNTYAIAGD SGSPLFAFDK 251 HENRWVLAGV LSTYAGFDNF FNKYIVTQPE FIRSTIRQYETRLDVGLTTN 301 ELIWRDNGNG NSTLQGLNER ITLPIANPSL APQNDSRHMP SEDAGKTLIL351 SSRFDNKTLM LADNINQGAG ALQFDSNFTV VGKNHTWQGA GVIVADGKRV 401FWQVSNPKGD RLSKLGAGTL IANGQGINQG DISIGEGTVV LAQKAASDGS 451 KQAFNQVGITSGRGTAVLAD SQQIKPENLY FGFRGGRLDL NGNNLAFTHI 501 RHADGGAQIV NHNPDQAATLTLTGNPVLSP EHVEWVQWGN RPQGNAAVYE 551 YINPHRNRRT DYFILKPGGN PREFFPLNMKNSTSWQFIGN NRQQAAEQVA 601 QAENARPDLI TFGGYLGENA QTGKAAPSYS KTNEAAIEKTRHIANAAVYG 651 RPEYRYNGAL NLHYRPKRTD STLLLNGGMN LNGEVLIEGG NMIVSGRPVP701 HAYDHQAKRE PVLENEWTDG SFKAARFTLR NHARLTAGRN TAHLDGDITA 751YDLSGIDLGF TQGKTPECYR SYHSGSTHCT PNAVLKAENY RALPATQVRG 801 DITLNDRSELRLGKAHLYGS IRAGKDTAVR MEADSNWTLS QSSHTGALTL 851 DGAQITLNPD FANNTHNNRFNTLTVNGTLD GFGTFRFLTG IVRKQNAPPL 901 KLEGDSRGAF QIHVKNTGQE PQTTESLALVSLNPKHSHQA RFTLQNGYAD 951 LGAYRYILRK NNNGYSLYNP LKEAELQIEA TRAEHERNQQAYNQLQATDI 1001 SRQVQHDSDA TRQALQAWQN SQTELARIDS QVQYLSAQLK QTDPLTGILT1051 RAQNLCAAQG YSADICRQVA KAADTNDLTL FETELDTYIE RVEMAESELD 1101KARQGGDAQA VETARHAYLN ALNRLSRQIH SLKTGVAGIR MPNLAELISR 1151 SANTAVSEQAAYNTGRQQAG RRIDRHLTDP QQQNIWLETG TQQTDYHSGT 1201 HRPYQQTTNY AHIGIQTGITDRLSVGTILT DERTNNRFDE GVSARNRSNG 1251 AHLFVKGENG ALFAAADLGY SNSRTRFTDYDGAAVRRHAW DAGINTGIKI 1301 DTGINLRPYA GIRINRSNGN RYVLDGAEIN SPAQIQTTWHAGIRLDKTVE 1351 LGQAKLTPAF SSDYYHTRQN SGSALSVNDR TLLQQAAHGT LHTLQIDAGY1401 KGWNAKLHAA YGKDSNTARH KQAGIKIGYN W*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2603>:

g760.seq (partial) 1 AACAACCGCA ACACCCGTTA CGCCGCATTG GGCAAACGCGTGATGGAAGG 51 CGTTGAGACC GAAATCAGCG GTGCGATTAC ACCGAAATGG CAAATCCATG 101CAGGTTACAG CTATCTGCAC AGCCAAATCA AAACCGCCGC CAATCCACGC 151 GACGACGGCATCTTCCTGCT GGTGCCCAAA CACAGCGCAA ACCTGTGGAC 201 GACTTACCAA GTTACGCCCGGGCTGACCGT CGGCGGCGGC GTGAACGCGA 251 TGAGCGGCAT TACTTCATCT GCAGGGATGCATGCAGGCGG TTATGCCACG 301 TTCGATGCGA TGGCGGCATA CCGCTTCACG CCCAAGCTGAAGCTGCAAAT 351 CAATGCCGAC AACATCTTCA ACCGCCATTA CTACGCCCGC GTCGGCGGCA401 CGAACACCTT TAACATTCCC GGTTCGGAGC GCAGCCTGAC GGCAAACCTG 451CGTTACAGTT TTTAAThis corresponds to the amino acid sequence <SEQ ID 2604; ORF 760.ng>:

g760.pep (partial) 1 NNRNTRYAAL GKRVMEGVET EISGAITPKW QIHAGYSYLHSQIKTAANPR 51 DDGIFLLVPK HSANLWTTYQ VTPGLTVGGG VNAMSGITSS AGMHAGGYAT 101FDAMAAYRFT PKLKLQINAD NIFNRHYYAR VGGTNTFNIP GSERSLTANL 151 RYSF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2605>:

m760.seq 1 ATGGGACAGT TTATGTCAGT TTTCCGCATC AATATGACCG CCGCCACGGT 51TTTGGCAGCA CTCTCGTCTT CGGTTTTTGC CGCACAAACG GAAGGTTTGG 101 AAACCGTCCATATTAAGGGT CAGCGTTCTT ACAACGCGAT TGCCACCGAG 151 AAAAACGGCG ATTACAGCTCGTTTGCCGCC ACCGTCGGTA CAAAAATCCC 201 CGCTTCTTTG CGCGAAATTC CGCAATCCGTCAGCATCATT ACCAACCAGC 251 AGGTCAAAGA CCGCAATGTT GATACGTTTG ACCAGTTGGCACGCAAAACG 301 CCCGGCCTGC GCGTGTTGAG CAACGACGAC GGACGCTCTT CGGTTTACGC351 GCGCGGTTAC GAATACAGCG AATACAACAT CGACGGCCTG CCCGCGCAGA 401TGCAGAGTAT CAACGGCACG CTGCCCAACC TGTTCGCCTT CGACCGCGTG 451 GAAGTGATGCGCGGGCCGAG CGGACTGTTC GACAGCAGCG GCGAGATGGG 501 CGGCATCGTG AATCTGGTGCGCAAACGCCC GACCAAAGCG TTCCAAGGTC 551 ATGCGGCGGC AGGGTTCGGT ACGCACAAACAATATAAAGC CGAGGCGGAC 601 GTATCGGGCA GCCTCAATTC AGACGGCAGC GTGCGCGGCCGCGTGATGGC 651 GCAGACCGTC GGCGCGTCTC CGCGTCCCGC CGAGAAAAAC AACCGGCGCG701 AAACCTTCTA CGCGGCGGCG GATTGGGACA TCAACCCCGA TACGGTTTTG 751GGCGCGGGCT ATCTTTACCA GCAACGCCGC CTCGCGCCGT ACAACGGCCT 801 GCCTGCCGATGCCAATAACA AATTACCGTC CCTGCCGCAA CACGTATTTG 851 TCGGCGCGGA TTGGAACAAATTTAAAATGC ACAGCCACGA CGTGTTCGCC 901 GATTTGAAAC ATTACTTCGG CAACGGCGGCTACGGCAAAG TCGGTATGCG 951 CTATTCCGAT CGGAAAGCCG ATTCCAATTA TACGTTTGCGGGCAGCAAAC 1001 TCAACAATAC CGGACAAGCC GACGTAGCGG GTTTGGGTAC GGACATTAAA1051 CAAAAAGCCT TTGCGGTTGA CGCAAGTTAC AGCCGTCCGT TTGCCTTGGG 1101CAACACCGCC AACGAATTTG TGATTGGTGC AGACTACAAC CGCTTGCGCA 1151 GTACTAATGAACAAGGGCGT TCGACTTTGT CAAAAAGCGT CGCTTTAGAT 1201 GGTTTCCGCG CTTTGCCTTATAACGGCATA CTTCAGAACG CCCGCGCCGG 1251 AAACAAAGGT TTCAATCACT CCGTTACCGAAGAAAACCTC GACGAAACCG 1301 GTTTGTATGC CAAGACGGTG TTCCGTCCTC TGGAAGGTTTGTCGTTGATT 1351 GCAGGCGGAC GTGTAGGACA TCACAAAATC GAGTCGGGCG ACGGCAAAAC1401 CCTGCATAAA GCTTCGAAAA CCAAATTTAC AAGCTACGCC GGCGCGGTTT 1451ACGATATAGA CGGCAGCAAC AGCCTGTACG CTTCCGCCTC CCAACTCTAC 1501 ACACCGCAAACCAGCATCGG CACCGACGGC AAGCTGCTCA AACCGCGCGA 1551 AGGCAACCAG TTTGAAATCGGCTACAAAGG CAGCTACATG GACGACCGCC 1601 TCAATACCCG GGTTTCGTTC TACCGCATGAAGGATAAAAA CGCCGCCGCA 1651 CCGCTGGACT CAAACAACAA AAAAACCCGT TACGCCGCATTGGGCAAACG 1701 CGTGATGGAA GGTGTTGAGA CCGAAATCAG CGGCGCGATG ACACCGAAAT1751 GGCAAATCCA TGCAGGTTAC AGCTACCTGC ACAGCCAAAT CAAAACCGCC 1801TCCAATTCGC GCGACGAAGG CATCTTCCTG CTGATGCCCA AACACAGCGC 1851 AAACCTGTGGACGACTTACC AAGTTACGTC CGGGCTGACC ATCGGCGGCG 1901 GCGTGAACGC GATGAGCGGCATTACTTCAT CTGCAGGGAT ACATGCAGGC 1951 GGTTATGCCA CGTTCGATGC GATGGCGGCATACCGCTTCA CGCCCAAACT 2001 GAAGCTGCAA ATCAACGCCG ACAACATCTT CAACCGCCATTACTACGCCC 2051 GCGTCGGCAG CGAGAGCACC TTTAACATTC CCGGTTCGGA GCGCAGCCTG2101 ACGGCAAACC TGCGTTACAG TTTTTAAThis corresponds to the amino acid sequence <SEQ ID 2606; ORF 760>:

m760.pep 1 MGQFMSVFRI NMTAATVLAA LSSSVFAAQT EGLETVHIKG QRSYNAIATE 51KNGDYSSFAA TVGTKIPASL REIPQSVSII TNQQVKDRNV DTFDQLARKT 101 PGLRVLSNDDGRSSVYARGY EYSEYNIDGL PAQMQSINGT LPNLFAFDRV 151 EVMRGPSGLF DSSGEMGGIVNLVRKRPTKA FQGHAAAGFG THKQYKAEAD 201 VSGSLNSDGS VRGRVMAQTV GASPRPAEKNNRRETFYAAA DWDINPDTVL 251 GAGYLYQQRR LAPYNGLPAD ANNKLPSLPQ HVFVGADWNKFKMHSHDVFA 301 DLKHYFGNGG YGKVGMRYSD RKADSNYTFA GSKLNNTGQA DVAGLGTDIK351 QKAFAVDASY SRPFALGNTA NEFVIGADYN RLRSTNEQGR STLSKSVALD 401GFRALPYNGI LQNARAGNKG FNHSVTEENL DETGLYAKTV FRPLEGLSLI 451 AGGRVGHHKIESGDGKTLHK ASKTKFTSYA GAVYDIDGSN SLYASASQLY 501 TPQTSIGTDG KLLKPREGNQFEIGYKGSYM DDRLNTRVSF YRMKDKNAAA 551 PLDSNNKKTR YAALGKRVME GVETEISGAMTPKWQIHAGY SYLHSQIKTA 601 SNSRDEGIFL LMPKHSANLW TTYQVTSGLT IGGGVNAMSGITSSAGIHAG 651 GYATFDAMAA YRFTPKLKLQ INADNIFNRH YYARVGSEST FNIPGSERSL701 TANLRYSF* m760/g760 91.6% identity in 154 aa overlap   530       540       550       560       570       580 m760.pepYKGSYMDDRLNTRVSFYRMKDKNAAAPLDSNNKKTRYAALGKRVMEGVETEISGAMTPKW                              ||::|||||||||||||||||||||:|||| g760                              NNRNTRYAALGKRVMEGVETEISGAITPKW                                      10        20        30   590       600       610       620       630       640 m760.pepQIHAGYSYLHSQIKTASNSRDEGIFLLMPKHSANLWTTYQVTSGLTIGGGVNAMSGITSS||||||||||||||||:| ||:|||||:|||||||||||||| |||:||||||||||||| g760QIHAGYSYLHSQIKTAANPRDDGIFLLVPKHSANLWTTYQVTPGLTVGGGVNAMSGITSS        40        50        60        70        80        90   650       660       670       680       690       700 m760.pepAGIHAGGYATFDAMAAYRFTPKLKLQINADNIFNRHYYARVGSESTFNIPGSERSLTANL||:|||||||||||||||||||||||||||||||||||||||: :||||||||||||||| g760AGMHAGGYATFDAMAAYRFTPKLKLQINADNIFNRHYYARVGGTNTFNIPGSERSLTANL       100       110       120       130       140       150   709m760.pep RYSFX ||||| g760 RYSFX

g761.seq not found yet

g761.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2607>:

m761.seq 1 ATGAAAATAT CATTTCATTT AGCTTTATTA CCCACGCTGA TTATTGCTTC 51CTTCCCTGTT GCTGCCGCCG ATACGCAGGA CAATGGTGAA CATTACACCG 101 CCACTCTGCCCACCGTTTCC GTGGTCGGAC AGTCCGACAC CAGCGTACTC 151 AAAGGCTACA TCAACTACGACGAAGCCGCC GTTACCCGCA ACGGACAGCT 201 CATCAAAGAA ACGCCGCAAA CCATCGATACGCTCAATATC CAGAAAAACA 251 AAAATTACGG TACGAACGAT TTGAGTTCCA TCCTCGAAGGCAATGCCGGC 301 ATCGACGCTG CCTACGATAT GCGCGGTGAA AGCATTTTCC TGCGCGGTTT351 TCAAGCCGAC GCATCCGATA TTTACCGCGA CGGCGTGCGC GAAAGCGGAC 401AAGTGCGCCG CAGTACTGCC AACATCGAGC GCGTGGAAAT CCTGAAAGGC 451 CCGTCTTCCGTGCTTTACGG CCGCACCAAC GGCGGCGGCG TCATCAACAT 501 GGTCAGCAAA TACGCCAACTTCAAACAAAG CCGCAACATC GGAGCGGTTT 551 ACGGCTCATG GGCAAACCGC AGCCTGAATATGGACATTAA CGAAGTGCTG 601 AACAAAAACG TCGCCATCCG TCTCACCGGC GAAGTCGGGCGCGCCAATTC 651 GTTCCGCAGC GGCATAGACA GCAAAAATGT CATGGTTTCG CCCAGCATTA701 CCGTCAAACT CGACAACGGC TTGAAGTGGA CGGGGCAATA CACCTACGAC 751AATGTGGAGC GCACGCCCGA CCGCAGTCCG ACCAAGTCCG TGTACGACCG 801 CTTCGGACTGCCTTACCGCA TGGGGTTCGC CCACCGGAAC GATTTTGTCA 851 AAGACAAGCT GCAAGTTTGGCGTTCCGACC TTGAATACGC CTTCAACGAC 901 AAATGGCGTG CCCAATGGCA GCTCGCCCACCGCACGGCGG CGCAGGATTT 951 TGATCATTTC TATGCAGGCA GCGAAAATGG CAACTTAATCAAACGTAACT 1001 ACGCCTGGCA GCAGACCGAC AACAAAACCC TGTCGTCCAA CTTAACGCTC1051 AACGGCGACT ACACCATCGG CCGTTTTGAA AACCACCTGA CCGTAGGCAT 1101GGATTACAGC CGCGAACACC GCAACCCGAC ATTGGGTTTC AGCAGCGCCT 1151 TTTCCGCCTCCATCAACCCC TACGACCGCG CAAGCTGGCC GGCTTCGGGC 1201 AGATTGCAGC CTATTCTGACCCAAAACCGC CACAAAGCCG ACTCCTACGG 1251 CATCTTTGTG CAAAACATCT TCTCCGCCACGCCCGATTTG AAATTCGTCC 1301 TCGGCGGCCG TTACGACAAA TACACCTTTA ATTCCGAAAACAAACTCACC 1351 GGCAGCAGCC GCCAATACAG CGGACACTCG TTCAGCCCCA ACATCGGCGC1401 AGTGTGGAAC ATCAATCCCG TCCACACACT TTACGCCTCG TATAACAAAG 1451GCTTCGCGCC TTATGGCGGA CGCGGCGGCT ATTTGAGCAT CGATACGTTG 1501 TCTTCCGCCGTGTTCAACGC CGACCCCGAG TACACCCGCC AATACGAAAC 1551 CGGCGTGAAA AGCAGTTGGCTGGACGACCG CCTCAGCACT ACGTTGTCTG 1601 CCTACCAAAT CGAACGCTTC AATATCCGCTACCGCCCCGA TCCAAAAAAC 1651 AACCCTTATA TTTATGCGGT TAGCGGCAAA CACCGTTCGCGCGGCGTGGA 1701 ATTGTCCGCC ATCGGGCAAA TCATCCCCAA AAAACTCTAT CTGCGCGGTT1751 CGTTGGGCGT GATGCAGGCG AAAGTCGTTG AAGACAAAGA AAATCCCGAC 1801CGAGTGGGCA TCCATTTGAA TAATACCAGC AACGTTACCG GCAACCTGTT 1851 TTTCCGTTATACCCCGACCG AAAACCTCTA CGGCGAAATC GGCGTAACCG 1901 GTACAGGCAA ACGCTACGGTTACAACTCAA GAAATAAAGA AGTGACTACG 1951 CTTCCAGGCT TTGCCCGAGT TGATGCCATGCTTGGCTGGA ACCATAAAAA 2001 TGTTAACGTT ACCTTTGCCG CAGCCAATCT GCTCAATCAAAAATATTGGC 2051 GTTCGGACTC TATGCCGGGT AATCCGCGCG GCTATACTGC CCGGGTAAAT2101 TACCGTTTCT GAThis corresponds to the amino acid sequence <SEQ ID 2608; ORF 761>:

m761.pep 1 MKISFHLALL PTLIIASFPV AAADTQDNGE HYTATLPTVS VVGQSDTSVL 51KGYINYDEAA VTRNGQLIKE TPQTIDTLNI QKNKNYGTND LSSILEGNAG 101 IDAAYDMRGESIFLRGFQAD ASDIYRDGVR ESGQVRRSTA NIERVEILKG 151 PSSVLYGRTN GGGVINMVSKYANFKQSRNI GAVYGSWANR SLNMDINEVL 201 NKNVAIRLTG EVGRANSFRS GIDSKNVMVSPSITVKLDNG LKWTGQYTYD 251 NVERTPDRSP TKSVYDRFGL PYRMGFAHRN DFVKDKLQVWRSDLEYAFND 301 KWRAQWQLAH RTAAQDFDHF YAGSENGNLI KRNYAWQQTD NKTLSSNLTL351 NGDYTIGRFE NHLTVGMDYS REHRNPTLGF SSAFSASINP YDRASWPASG 401RLQPILTQNR HKADSYGIFV QNIFSATPDL KFVLGGRYDK YTFNSENKLT 451 GSSRQYSGHSFSPNIGAVWN INPVHTLYAS YNKGFAPYGG RGGYLSIDTL 501 SSAVFNADPE YTRQYETGVKSSWLDDRLST TLSAYQIERF NIRYRPDPKN 551 NPYIYAVSGK HRSRGVELSA IGQIIPKKLYLRGSLGVMQA KVVEDKENPD 601 RVGIHLNNTS NVTGNLFFRY TPTENLYGEI GVTGTGKRYGYNSRNKEVTT 651 LPGFARVDAM LGWNHKNVNV TFAAANLLNQ KYWRSDSMPG NPRGYTARVN701 YRF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2609>:

a761.seq 1 ATGAAAATAT CATTTCATTT AGCTTTATTA CCCACGCTGA TTATTGCTTC 51CTTCCCTGTT GCTGCCGCCG ATACGCAGGA CAATGGTGAA CATTACACCG 101 CCACTCTGCCCACCGTTTCC GTGGTCGGAC AGTCCGACAC CAGCGTACTC 151 AAAGGCTACA TCAACTACGACGAAGCCGCC GTTACCCGCA ACGGACAGCT 201 CATCAAAGAA ACGCCGCAAA CCATCGATACGCTCAATATC CAGAAAAACA 251 AAAATTACGG CACGAACGAT TTGAGTTCCA TCCTCGAAGGCAATGCCGGC 301 ATCGACGCCG CCTACGATAT GCGCGGCGAA AGCATTTTCC TGCGCGGCTT351 TCAAGCCGAC GCATCTGATA TTTACCGCGA CGGCGTACGC GAAAGCGGGC 401AGGTGCGCCG TAGCACCGCC AACATCGAGC GCGTGGAAAT CCTGAAAGGT 451 CCGTCCTCCGTGCTTTATGG GCGTACCAAC GGCGGCGGTG TCATCAACAT 501 GGTCAGCAAA TACGCCAACTTCAAACAAAG CCGTAATATC GGTACGGTTT 551 ATGGTTCGTG GGCAAACCGC AGCCTGAATATGGACATCAA CGAAGTGCTG 601 AACAAAAACG TCGCCATCCG TCTCACCGGC GAAGTCGGGCGCGCCAATTC 651 GTTCCGCAGC GGCATAGACA GCAAAAATGT CATGGTTTCG CCCAGCATTA701 CCGTCAAACT CGACAACGGC TTGAAGTGGA CGGGGCAATA CACCTACGAC 751AATGTGGAGC GCACGCCCGA CCGCAGTCCG ACCAAGTCCG TGTACGACCG 801 CTTCGGACTGCCTTACCGCA TGGGGTTCGC CCACCGGAAC GATTTTGTCA 851 AAGACAAGCT GCAAGTTTGGCGTTCCGACC TTGAATACGC CTTCAACGAC 901 AAATGGCGTG CCCAATGGCA GCTCGCCCACCGCACGGCGG CGCAGGATTT 951 TGATCATTTC TATGCAGGCA GCGAAAATGG CAACTTAATCAAACGTAACT 1001 ACGCCTGGCA GCAGACCGAC AACAAAACCC TGTCGTCCAA CTTAACGCTC1051 AACGGCGACT ACACCATCGG CCGTTTTGAA AACCACCTGA CCGTAGGCAT 1101GGATTACAGC CGCGAACACC GCAACCCGAC ATTGGGTTTC AGCAGCGCCT 1151 TTTCCGCCTCCATCAACCCC TACGACCGCG CAAGCTGGCC GGCTTCGGGC 1201 AGATTGCAGC CTATTCTGACCCAAAACCGC CACAAAGCCG ACTCCTACGG 1251 CATCTTTGTG CAAAACATCT TCTCCGCCACGCCCGATTTG AAATTCGTCC 1301 TCGGCGGCCG TTACGACAAA TACACCTTTA ATTCCGAAAACAAACTCACC 1351 GGCAGCAGCC GCCAATACAG CGGACACTCG TTCAGCCCCA ACATCGGCGC1401 AGTGTGGAAC ATCAATCCCG TCCACACACT TTACGCCTCG TATAACAAAG 1451GCTTCGCGCC TTATGGCGGA CGCGGCGGCT ATTTGAGCAT CGATACGTTG 1501 TCTTCCGCCGTGTTCAACGC CGACCCCGAG TACACCCGCC AATACGAAAC 1551 CGGCGTGAAA AGCAGTTGGCTGGACGACCG CCTCAGCACT ACGTTGTCTG 1601 CCTACCAAAT CGAACGCTTC AATATCCGCTACCGCCCCGA TCCAAAAAAC 1651 AACCCTTATA TTTATGCGGT TAGCGGCAAA CACCGTTCGCGCGGCGTGGA 1701 ATTGTCCGCC ATCGGGCAAA TCATCCCCAA AAAACTCTAT CTGCGCGGTT1751 CGTTGGGCGT GATGCAGGCG AAAGTCGTTG AAGACAAAGA AAATCCCGAC 1801CGAGTGGGCA TCCATTTGAA TAACACCAGC AACGTTACCG GCAACCTGTT 1851 TTTCCGTTATACCCCGACCG AAAACCTCTA CGGCGAAATC GGCGTAACCG 1901 GTACAGGCAA ACGCTACGGTTACGACTCAA GAAATAAAGA AGTGACTACG 1951 CTTCCAGGCT TTGCCCGAGT TGATGCCATGCTTGGCTGGA ACCATAAAAA 2001 TGTTAACGTT ACCTTTGCCG CAGCCAATCT GTTCAATCAAAAATATTGGC 2051 GTTCGGACTC TATGCCGGGT AATCCGCGCG GCTATACTGC CCGGGTAAAT2101 TACCGTTTCT GAThis corresponds to the amino acid sequence <SEQ ID 2610; ORF 761.a>:

a761.pep 1 MKISFHLALL PTLIIASFPV AAADTQDNGE HYTATLPTVS VVGQSDTSVL 51KGYINYDEAA VTRNGQLIKE TPQTIDTLNI QKNKNYGTND LSSILEGNAG 101 IDAAYDMRGESIFLRGFQAD ASDIYRDGVR ESGQVRRSTA NIERVEILKG 151 PSSVLYGRTN GGGVINMVSKYANFKQSRNI GTVYGSWANR SLNMDINEVL 201 NKNVAIRLTG EVGRANSFRS GIDSKNVMVSPSITVKLDNG LKWTGQYTYD 251 NVERTPDRSP TKSVYDRFGL PYRMGFAHRN DFVKDKLQVWRSDLEYAFND 301 KWRAQWQLAH RTAAQDFDHF YAGSENGNLI KRNYAWQQTD NKTLSSNLTL351 NGDYTIGRFE NHLTVGMDYS REHRNPTLGF SSAFSASINP YDRASWPASG 401RLQPILTQNR HKADSYGIFV QNIFSATPDL KFVLGGRYDK YTFNSENKLT 451 GSSRQYSGHSFSPNIGAVWN INPVHTLYAS YNKGFAPYGG RGGYLSIDTL 501 SSAVFNADPE YTRQYETGVKSSWLDDRLST TLSAYQIERF NIRYRPDPKN 551 NPYIYAVSGK HRSRGVELSA IGQIIPKKLYLRGSLGVMQA KVVEDKENPD 601 RVGIHLNNTS NVTGNLFFRY TPTENLYGEI GVTGTGKRYGYDSRNKEVTT 651 LPGFARVDAM LGWNHKNVNV TFAAANLFNQ KYWRSDSMPG NPRGYTARVN701 YRF* m761/a761 99.6% identity in 703 aa overlap        10        20        30        40        50        60 m761.pepMKISFHLALLPTLIIASFPVAAADTQDNGEHYTATLPTVSVVGQSDTSVLKGYINYDEAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a761MKISFHLALLPTLIIASFPVAAADTQDNGEHYTATLPTVSVVGQSDTSVLKGYINYDEAA        10        20        30        40        50        60        70        80        90       100       110       120 m761.pepVTRNGQLIKETPQTIDTLNIQKNKNYGTNDLSSILEGNAGIDAAYDMRGESIFLRGFQAD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a761VTRNGQLIKETPQTIDTLNIQKNKNYGTNDLSSILEGNAGIDAAYDMRGESIFLRGFQAD        70        80        90       100       110       120       130       140       150       160       170       180 m761.pepASDIYRDGVRESGQVRRSTANIERVEILKGPSSVLYGRTNGGGVINMVSKYANFKQSRNI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a761ASDIYRDGVRESGQVRRSTANIERVEILKGPSSVLYGRTNGGGVINMVSKYANFKQSRNI       130       140       150       160       170       180       190       200       210       220       230       240 m761.pepGAVYGSWANRSLNMDINEVLNKNVAIRLTGEVGRANSFRSGIDSKNVMVSPSITVKLDNG|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a761GTVYGSWANRSLNMDINEVLNKNVAIRLTGEVGRANSFRSGIDSKNVMVSPSITVKLDNG       190       200       210       220       230       240       250       260       270       280       290       300 m761.pepLKWTGQYTYDNVERTPDRSPTKSVYDRFGLPYRMGFAHRNDFVKDKLQVWRSDLEYAFND|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a761LKWTGQYTYDNVERTPDRSPTKSVYDRFGLPYRMGFAHRNDFVKDKLQVWRSDLEYAFND       250       260       270       280       290       300       310       320       330       340       350       360 m761.pepKWRAQWQLAHRTAAQDFDHFYAGSENGNLIKRNYAWQQTDNKTLSSNLTLNGDYTIGRFE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a761KWRAQWQLAHRTAAQDFDHFYAGSENGNLIKRNYAWQQTDNKTLSSNLTLNGDYTIGRFE       310       320       330       340       350       360       370       380       390       400       410       420 m761.pepNHLTVGMDYSREHRNPTLGFSSAFSASINPYDRASWPASGRLQPILTQNRHKADSYGIFV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a761NHLTVGMDYSREHRNPTLGFSSAFSASINPYDRASWPASGRLQPILTQNRHKADSYGIFV       370       380       390       400       410       420       430       440       450       460       470       480 m761.pepQNIFSATPDLKFVLGGRYDKYTFNSENKLTGSSRQYSGHSFSPNIGAVWNINPVHTLYAS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a761QNIFSATPDLKFVLGGRYDKYTFNSENKLTGSSRQYSGHSFSPNIGAVWNINPVHTLYAS       430       440       450       460       470       480       490       500       510       520       530       540 m761.pepYNKGFAPYGGRGGYLSIDTLSSAVFNADPEYTRQYETGVKSSWLDDRLSTTLSAYQIERF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a761YNKGFAPYGGRGGYLSIDTLSSAVFNADPEYTRQYETGVKSSWLDDRLSTTLSAYQIERF       490       500       510       520       530       540       550       560       570       580       590       600 m761.pepNIRYRPDPKNNPYIYAVSGKHRSRGVELSAIGQIIPKKLYLRGSLGVMQAKVVEDKENPD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a761NIRYRPDPKNNPYIYAVSGKHRSRGVELSAIGQIIPKKLYLRGSLGVMQAKVVEDKENPD       550       560       570       580       590       600       610       620       630       640       650       660 m761.pepRVGIHLNNTSNVTGNLFFRYTPTENLYGEIGVTGTGKRYGYNSRNKEVTTLPGFARVDAM|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||| a761RVGIHLNNTSNVTGNLFFRYTPTENLYGEIGVTGTGKRYGYDSRNKEVTTLPGFARVDAM       610       620       630       640       650       660       670       680       690       700 m761.pepLGWNHKNVNVTFAAANLLNQKYWRSDSMPGNPRGYTARVNYRFX|||||||||||||||||:|||||||||||||||||||||||||| a761LGWNHKNVNVTFAAANLFNQKYWRSDSMPGNPRGYTARVNYRFX       670       680       690       700

g762.seq Not yet found

g762.pep Not yet found

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2611>:

m762.seq 1 ATGAAGTGGT TATTAAATAT GATAATGAGA CCTATTAAAT TTAGTATGGT 51AAATACGTTA TTATTTATTG TTATATGTAG TTCATTTTTT GATCTGCTCG 101 TTCAATTATGTACAATTTTA TTTCATAGCC AAAAAATATA CTTTATTACA 151 TTATTTTTAT TATTTATTTTTAATTTTGTT ACAAAATCTA TCTATATGGC 201 AATTATTTAT CCTATTTTAT ATTTTTTTACGATAAAAAAA TATTATCCTT 251 ACTCTAGGAA AGTGATAATT CTATTATCAT TAGCATTATCTATATATTTT 301 AGTTTTATGG ACTTTTACTT TTTTTCCATA TATTCAGATA ACCTTAGCTA351 TGAAACGGAG CCTTTACATT TATACATCCC TATTATTATT AATTTTTTCT 401CACTTTTAGT TTCTAATTTT ATTTTATCTT TTATCAACAA GTAAThis corresponds to the amino acid sequence <SEQ ID 2612; ORF 762>:

m762.pep 1 MKWLLNMIMR PIKFSMVNTL LFIVICSSFF DLLVQLCTIL FHSQKIYFIT 51LFLLFIFNFV TKSIYMAIIY PILYFFTIKK YYPYSRKVII LLSLALSIYF 101 SFMDFYFFSIYSDNLSYETE PLHLYIPIII NFFSLLVSNF ILSFINK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2613>:

a762.seq 1 ATGAAGTGGT TATTAAATAT GATAATGAGA CCTATTAAAT TTAGTATGGT 51AAATACGTTA TTATTTATTG TTATATGTAG TTCATTTTTT GATCTGCTCG 101 TTCAATTATGTACAATTTTA TTTCATAGCC AAAAAATATA CTTTATTACA 151 TTATTTTTAT TATTTATTTTTAATTTTGTT ACAAAATCTA TCTATATGGC 201 AATTATTTAT CCTATTTTAT ATTTTTTTACGATAAAAAAA TATTATCCTT 251 ACTCTAGGAA AGTGATAATT CTATTATCAT TAGCATTATCTATATATTTT 301 AGTTTTATGG ACTTTTACTT TTTTTCCATA TATTCAGATA ACCTTAGCTA351 TGAAACGGAG CCTTTACATT TATACATCCC TATTATTATT AATTTTTTCT 401CACTTTTAGT TTCTAATTTT ATTTTATCTT TTATCAACAA GTAAThis corresponds to the amino acid sequence <SEQ ID 2614; ORF 762.a>:

a762.pep 1 MKWLLNMIMR PIKFSMVNTL LFIVICSSFF DLLVQLCTIL FHSQKIYFIT 51LFLLFIFNFV TKSIYMAIIY PILYFFTIKK YYPYSRKVII LLSLALSIYF 101 SFMDFYFFSIYSDNLSYETE PLHLYIPIII NFFSLLVSNF ILSFINK* m762/a762 100.0% identity in147 aa overlap        10        20        30        40        50        60 m762.pepMKWLLNMIMRPIKFSMVNTLLFIVICSSFFDLLVQLCTILFHSQKIYFITLFLLFIFNFV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a762MKWLLNMIMRPIKFSMVNTLLFIVICSSFFDLLVQLCTILFHSQKIYFITLFLLFIFNFV        10        20        30        40        50        60        70        80        90       100       110       120 m762.pepTKSIYMAIIYPILYFFTIKKYYPYSRKVIILLSLALSIYFSFMDFYFFSIYSDNLSYETE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a762TKSIYMAIIYPILYFFTIKKYYPYSRKVIILLSLALSIYFSFMDFYFFSIYSDNLSYETE        70        80        90       100       110       120       130       140 m762.pep PLHLYIPIIINFFSLLVSNFILSFINKX|||||||||||||||||||||||||||| a762 PLHLYIPIIINFFSLLVSNFILSFINKX       130       140

g763.seq not yet found

g763.pep not yet found

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2615>:

m763.seq 1 ATGACATTGC TCAATCTAAT GATAATGCAA GATTACGGTA TTTCCGTTTG 51CCTGACACTG ACGCCCTATT TGCAACATGA ACTATTTTCG GCTATGAAAT 101 CCTATTTTTCCAAATATATC CTACCCGTTT CACTTTTTAC CTTGCCACTA 151 TCCCTTTCCC CATCCGTTTCGGCTTTTACG CTGCCTGAAG CATGGCGGGC 201 GGCGCAGCAA CATTCGGCTG ATTTTCAAGCGTCCCATTAC CAGCGTGATG 251 CAGTGCGCGC ACGGCAACAA CAAGCCAAGG CCGCATTCCTTCCCCATGTA 301 TCCGCCAATG CCAGCTACCA GCGCCAGCCG CCATCGATTT CTTCCACCCG351 CGAAACACAG GGATGGAGCG TGCAGGTGGG ACAAACCTTA TTTGACGCTG 401CCAAATTTGC ACAATACCGC CAAAGCAGGT TCGATACGCA GGCTGCAGAA 451 CAGCGTTTCGATGCGGCACG CGAAGAATTG CTGTTGAAAG TTGCCGAAAG 501 TTATTTCAAC GTTTTACTCAGCCGAGACAC CGTTGCCGCC CATGCGGCGG 551 AAAAAGAGGC TTATGCCCAG CAGGTAAGGCAGGCGCAGGC TTTATTCAAT 601 AAAGGTGCTG CCACCGCGCT GGATATTCAC GAAGCCAAAGCCGGTTACGA 651 CAATGCCCTG GCCCAAGAAA TCGCCGTATT GGCTGAGAAA CAAACCTATG701 AAAACCAGTT GAACGACTAC ACCGACCTGG ATAGCAAACA AATCGAGGCC 751ATAGATACCG CCAACCTGTT GGCACGCTAT CTGCCCAAGC TGGAACGTTA 801 CAGTCTGGATGAATGGCAGC GCATTGCCTT ATCCAACAAT CATGAATACC 851 GGATGCAGCA GCTTGCCCTGCAAAGCAGCG GACAGGCGCT TCGGGCAGCA 901 CAGAACAGCC GCTATCCCAC CGTTTCTGCCCATGTCGGCT ATCAGAATAA 951 CCTCTACACT TCATCTGCGC AGAATAATGA CTACCACTATCGGGGCAAAG 1001 GGATGAGCGT CGGCGTACAG TTGAATTTGC CGCTTTATAC CGGCGGAGAA1051 TTGTCGGGCA AAATCCATGA AGCCGAAGCG CAATACGGGG CCGCCGAAGC 1101ACAGCTGACC GCAACCGAGC GGCACATCAA ACTCGCCGTA CGCCAGGCTT 1151 ATACCGAAAGCGGTGCGGCG CGTTACCAAA TCATGGCGCA AGAACGGGTT 1201 TTGGAAAGCA GCCGTTTGAAACTGAAATCG ACCGAAACCG GCCAACAATA 1251 CGGCATCCGC AACCGGCTGG AAGTAATACGGGCGCGGCAG GAAGTCGCCC 1301 AAGCAGAACA GAAACTGGCT CAAGCACGGT ATAAATTCATGCTGGCTTAT 1351 TTGCGCTTGG TGAAAGAGAG CGGGTTAGGG TTGGAAACGG TATTTGCGGA1401 ATAAThis corresponds to the amino acid sequence <SEQ ID 2616; ORF 763>:

m763.pep 1 MTLLNLMIMQ DYGISVCLTL TPYLQHELFS AMKSYFSKYI LPVSLFTLPL 51SLSPSVSAFT LPEAWRAAQQ HSADFQASHY QRDAVRARQQ QAKAAFLPHV 101 SANASYQRQPPSISSTRETQ GWSVQVGQTL FDAAKFAQYR QSRFDTQAAE 151 QRFDAAREEL LLKVAESYFNVLLSRDTVAA HAAEKEAYAQ QVRQAQALFN 201 KGAATALDIH EAKAGYDNAL AQEIAVLAEKQTYENQLNDY TDLDSKQIEA 251 IDTANLLARY LPKLERYSLD EWQRIALSNN HEYRMQQLALQSSGQALRAA 301 QNSRYPTVSA HVGYQNNLYT SSAQNNDYHY RGKGMSVGVQ LNLPLYTGGE351 LSGKIHEAEA QYGAAEAQLT ATERHIKLAV RQAYTESGAA RYQIMAQERV 401LESSRLKLKS TETGQQYGIR NRLEVIRARQ EVAQAEQKLA QARYKFMLAY 451 LRLVKESGLGLETVFAE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2617>:

a763.seq 1 ATGACATTGC TCAATCTAAT GATAATGCAA GATTACGGTA TTTCCGTTTG 51CCTGACACTG ACGCCCTATT TGCAACATGA ACTATTTTCG GCTATGAAAT 101 CCTATTTTTCCAAATATATC CTACCCGTTT CACTTTTTAC CTTGCCACTA 151 TCCCTTTCCC CATCCGTTTCGGCTTTTACG CTGCCTGAAG CATGGCGGGC 201 GGCGCAGCAA CATTCGGCTG ATTTTCAAGCGTCCCATTAC CAGCGTGATG 251 CAGTGCGCGC ACGGCAACAA CAAGCCAAGG CCGCATTCCTTCCCCATGTA 301 TCCGCCAATG CCAGCTACCA GCGCCAGCCG CCATCGATTT CTTCCACCCG351 CGAAACACAG GGATGGAGCG TGCAGGTGGG ACAAACCTTA TTTGACGCTG 401CCAAATTTGC ACAATACCGC CAAAGCAGGT TCGATACGCA GGCTGCAGAA 451 CAGCGTTTCGATGCGGCACG CGAAGAATTG CTGTTGAAAG TTGCCGAAAG 501 TTATTTCAAC GTTTTACTCAGCCGAGACAC CGTTGCCGCC CATGCGGCGG 551 AAAAAGAGGC TTATGCCCAG CAGGTAAGGCAGGCGCAGGC TTTATTCAAT 601 AAAGGTGCTG CCACCGCGCT GGATATTCAC GAAGCCAAAGCCGGTTACGA 651 CAATGCCCTG GCCCAAGAAA TCGCCGTATT GGCTGAGAAA CAAACCTATG701 AAAACCAGTT GAACGACTAC ACCGGCCTGG ACAGCAAACA AATCGAGGCC 751ATAGATACCG CCAACCTGTT GGCACGCTAT CTGCCGAAGC TGGAACGTTA 801 CAGTCTGGATGAATGGCAGC GCATTGCCTT ATCCAACAAT CATGAATACC 851 GGATGCAGCA GCTTGCCCTGCAAAGCAGCG GACAGGCGCT TCGGGCAGCA 901 CAGAACAGCC GCTATCCCAC CGTTTCTGCCCATGTCGGCT ATCAGAATAA 951 CCTCTACACT TCATCTGCGC AGAATAATGA CTACCACTATCGGGGCAAAG 1001 GGATGAGCGT CGGCGTACAG TTGAATTTGC CGCTTTATAC CGGCGGAGAA1051 TTGTCGGGCA AAATCCATGA AGCCGAAGCG CAATACGGGG CTGCCGAAGC 1101ACAGCTGACC GCAACCGAGC GGCACATCAA ACTCGCCGTA CGCCAGGCTT 1151 ATACCGAAAGCGGTGCGGCG CGTTACCAAA TCATGGCGCA AGAACGGGTT 1201 TTGGAAAGCA GCCGTTTGAAACTGAAATCG ACCGAAACCG GCCAACAATA 1251 CGGCATCCGC AACCGGCTGG AAGTAATACGGGCGCGGCAG GAAGTCGCCC 1301 AAGCAGAACA GAAACTGGCT CAAGCACGGT ATAAATTCATGCTGGCTTAT 1351 TTGCGCTTGG TGAAAGAGAG CGGGTTAGGG TTGGAAACGG TATTTGCGGA1401 ATAAThis corresponds to the amino acid sequence <SEQ ID 2618; ORF 763.a>:

a763.pep 1 MTLLNLMIMQ DYGISVCLTL TPYLQHELFS AMKSYFSKYI LPVSLFTLPL 51SLSPSVSAFT LPEAWRAAQQ HSADFQASHY QRDAVRARQQ QAKAAFLPHV 101 SANASYQRQPPSISSTRETQ GWSVQVGQTL FDAAKFAQYR QSRFDTQAAE 151 QRFDAAREEL LLKVAESYFNVLLSRDTVAA HAAEKEAYAQ QVRQAQALFN 201 KGAATALDIH EAKAGYDNAL AQEIAVLAEKQTYENQLNDY TGLDSKQIEA 251 IDTANLLARY LPKLERYSLD EWQRIALSNN HEYRMQQLALQSSGQALRAA 301 QNSRYPTVSA HVGYQNNLYT SSAQNNDYHY RGKGMSVGVQ LNLPLYTGGE351 LSGKIHEAEA QYGAAEAQLT ATERHIKLAV RQAYTESGAA RYQIMAQERV 401LESSRLKLKS TETGQQYGIR NRLEVIRARQ EVAQAEQKLA QARYKFMLAY 451 LRLVKESGLGLETVFAE* m763/a763 99.8% identity in 467 aa overlap        10        20        30        40        50        60 m763.pepMTLLNLMIMQDYGISVCLTLTPYLQHELFSAMKSYFSKYILPVSLFTLPLSLSPSVSAFT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a763MTLLNLMIMQDYGISVCLTLTPYLQHELFSAMKSYFSKYILPVSLFTLPLSLSPSVSAFT        10        20        30        40        50        60        70        80        90       100       110       120 m763.pepLPEAWRAAQQHSADFQASHYQRDAVRARQQQAKAAFLPHVSANASYQRQPPSISSTRETQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a763LPEAWRAAQQHSADFQASHYQRDAVRARQQQAKAAFLPHVSANASYQRQPPSISSTRETQ        70        80        90       100       110       120       130       140       150       160       170       180 m763.pepGWSVQVGQTLFDAAKFAQYRQSRFDTQAAEQRFDAAREELLLKVAESYFNVLLSRDTVAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a763GWSVQVGQTLFDAAKFAQYRQSRFDTQAAEQRFDAAREELLLKVAESYFNVLLSRDTVAA       130       140       150       160       170       180       190       200       210       220       230       240 m763.pepHAAEKEAYAQQVRQAQALFNKGAATALDIHEAKAGYDNALAQEIAVLAEKQTYENQLNDY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a763HAAEKEAYAQQVRQAQALFNKGAATALDIHEAKAGYDNALAQEIAVLAEKQTYENQLNDY       190       200       210       220       230       240       250       260       270       280       290       300 m763.pepTDLDSKQIEAIDTANLLARYLPKLERYSLDEWQRIALSNNHEYRMQQLALQSSGQALRAA| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a763TGLDSKQIEAIDTANLLARYLPKLERYSLDEWQRIALSNNHEYRMQQLALQSSGQALRAA       250       260       270       280       290       300       310       320       330       340       350       360 m763.pepQNSRYPTVSAHVGYQNNLYTSSAQNNDYHYRGKGMSVGVQLNLPLYTGGELSGKIHEAEA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a763QNSRYPTVSAHVGYQNNLYTSSAQNNDYHYRGKGMSVGVQLNLPLYTGGELSGKIHEAEA       310       320       330       340       350       360       370       380       390       400       410       420 m763.pepQYGAAEAQLTATERHIKLAVRQAYTESGAARYQIMAQERVLESSRLKLKSTETGQQYGIR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a763QYGAAEAQLTATERHIKLAVRQAYTESGAARYQIMAQERVLESSRLKLKSTETGQQYGIR       370       380       390       400       410       420       430       440       450       460 m763.pepNRLEVIRARQEVAQAEQKLAQARYKFMLAYLRLVKESGLGLETVFAEX|||||||||||||||||||||||||||||||||||||||||||||||| a763NRLEVIRARQEVAQAEQKLAQARYKFMLAYLRLVKESGLGLETVFAEX       430       440       450       460

g764.seq not found yet

g764.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2619>:

m764.seq 1 ATGTTTTTCT CCGCCCTGAA ATCCTTTCTT TCTCGATACA TTACTGTATG 51GCGCAATGTT TGGGCGGTGC GCGACCAGTT GAAACCGCCC AAACGCACGG 101 CGGAAGAACAGGCGTTTTTG CCCGCGCATT TGGAACTGAC CGATACGCCG 151 GTCTCTGCCG CTCCGAAATGGGCGGCGCGT TTTATTATGG CGTTTGCGCT 201 TTTGGCTTTG TTGTGGTCCT GGTTCGGCAAAATCGATATT GTGGCGGCGG 251 CTTCGGGCAA AACGGTGTCG GGCGGGCGCA GCAAAACCATCCAGCCGCTG 301 GAAACGGCGG TGGTTAAGGC GGTACATGTG CGCGACGGGC AGCATGTGAA351 ACAGGGAGAA ACGCTGGCGG AACTGGAGGC TGTGGGAACA GACAGCGATG 401TGGTGCAGTC GGAGCAGGCT TTGCAGGCTG CCCAATTGTC CAAACTGCGT 451 TATGAAGCGGTATTGGCGGC ATTGGAAAGC CGTACCGTGC CGCATATCGA 501 TATGGCGCAA GCACGGTCTTTAGGTCTCTC CGATGCCGAT GTGCAATCGG 551 CGCAGGTGTT GGCGCAGCAC CAGTATCAGGCATGGGCGGC GCAGGATGCG 601 CAATTGCAGT CGGCTTTGCG CGGCCATCAG GCGGAATTGCAGTCGGCCAA 651 GGCGCAGGAG CAGAAGCTGG TTTCGGTGGG GGCGATCGAG CAGCAGAAAA701 CAGCAGACTA CCGCCGTTTG CGGGCCGACA ATTTTATTTC GGAACATGCG 751TTTTTGGAGC AGCAGAGCAA ATCGGTCAGC AATTGGAACG ATTTGGAAAG 801 TACGCGCGGTCAGATGAGGC AGATTCAGGC GGCCATTGCA CAGGCGGAGC 851 AGAATCGGGT GCTGAATACGCAGAACCTGA AACGCGATAC GCTGGATGCG 901 CTGCGCCAGG CAAACGAACA GATTGACCAATACCGCGGCC AAACGGATAA 951 GGCAAAGCAG CGGCAGCAGC TGATGACAAT ACAGTCGCCTGCGGACGGCA 1001 CGGTGCAGGA ATTGGCTACC TATACGGTGG GCGGTGTGGT GCAGGCTGCC1051 CAAAAAATGA TGGTGATTGC GCCCGATGAC GACAAAATGG ACGTGGAAGT 1101TTTGGTATTG AACAAAGACA TCGGTTTTGT GGAACAGGGA CAGGATGCGG 1151 TGGTGAAGATTGAGAGCTTT CCCTATACGC GCTACGGTTA TCTGACGGGC 1201 AAGGTGAAAA GTGTCAGCCATGATGCGGTA AGCCACGAAC AGTTGGGCTT 1251 GGTTTATACG GCGGTGGTGT CGCTGGACAAACATACCTTG AATATTGACG 1301 GCAAAGCAGT GAATCTGACG GCGGGCATGA ATGTCACGGCGGAGATTAAA 1351 ACGGGTAAAC GGCGGGTGCT GGATTATCTG TTAAGCCCGC TGCAAACCAA1401 ATTGGACGAA AGCTTTAGGG AGCGATAGThis corresponds to the amino acid sequence <SEQ ID 2620; ORF 764>:

m764.pep 1 MFFSALKSFL SRYITVWRNV WAVRDQLKPP KRTAEEQAFL PAHLELTDTP 51VSAAPKWAAR FIMAFALLAL LWSWFGKIDI VAAASGKTVS GGRSKTIQPL 101 ETAVVKAVHVRDGQHVKQGE TLAELEAVGT DSDVVQSEQA LQAAQLSKLR 151 YEAVLAALES RTVPHIDMAQARSLGLSDAD VQSAQVLAQH QYQAWAAQDA 201 QLQSALRGHQ AELQSAKAQE QKLVSVGAIEQQKTADYRRL RADNFISEHA 251 FLEQQSKSVS NWNDLESTRG QMRQIQAAIA QAEQNRVLNTQNLKRDTLDA 301 LRQANEQIDQ YRGQTDKAKQ RQQLMTIQSP ADGTVQELAT YTVGGVVQAA351 QKMMVIAPDD DKMDVEVLVL NKDIGFVEQG QDAVVKIESF PYTRYGYLTG 401KVKSVSHDAV SHEQLGLVYT AVVSLDKHTL NIDGKAVNLT AGMNVTAEIK 451 TGKRRVLDYLLSPLQTKLDE SFRER*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2621>:

a764.seq (partial) 1 ATGTTTTTCT CCGCCCTGAA ATCCTTTCTT TCCCGCTACATTACCGTATG 51 GCGCAATGTT TGGGCGGTGC GCGACCAGTT GGAACCGCCC AAACGCACGG 101CGGAAGAACA GGCGTTTTTG CCCGCGCATT TGGAACTGAC CGATACGCCG 151 GTCTCTGCCGCTCCGAAATG GGCGGCGCGT TTTATTATGG CGTTTGCGCT 201 TTTGGCTTTG TTGTGGTCCTGGTTCGGCAA AATCGATATT GTGGCGGCGG 251 CTTCGGGCAA AACGGTGTCG GGCGGGCGCAGCAAAACCAT CCAGCCGCTG 301 GAAACGGTGG TGGTTAAGGC GGTACATGTG CGCGACGGGCAGCATGTGAA 351 ACAGGGAGAA ACGCTGGCGG AACTGGAGGC TGTGGGAACA GACAGCGATG401 TGGTGCAGTC GGAGCAGGCT TTGCAGGCTG CCCAATTGTC CAAACTGCGT 451TATGAAGCGG TATTGGCGGC ATTGGAAAGC CGTACCGTGC CGCATATCGA 501 TATGGCGCAAGCACGGTCTT TAGGTCTCTC CGATGCCGAT GTGCAATCGG 551 CGCAGGTGTT GGCGCAGCACCAGTATCAGG CATGGGCGGC GCAGGATGCG 601 CAATTGCAGT CGGCTTTGCG CGGCCATCAGGCGGAATTGC AGTCGGCCAA 651 GGCGCAGGAG CAGAAGCTGG TTTCGGTGGG GGCGATCGAGCAGCAGAAAA 701 CAGCAGACTA CCGCCGTTTG CGGGCCGACA ATTTTATTTC GGAACATGCG751 TTTTTGGAGC AGCAGAGCAA ATCGGTCAGC AATTGGAACG ATTTGGAAAG 801TACGCGCGGT CAGATGAGGC AGATTCAGGC GGCCATTGCA CAGGCGGAGC 851 AGAATCGGGTGCTGAATACG CAGAACCTGA AACGCGATAC GCTGGATGCG 901 CTGCGCCAGG CAAACGAACAGATTGACCAA TACCGCGGCC AAACGGATAA 951 GGCAAAGCAG CGGCAGCAGC TGATGACAATACAGTCGCCT GCGGACGGCA 1001 CGGTGCAGGA ATTGGCCACC TATACGGTGG GCGGTGTGGTGCAGGCTGCC 1051 CAAAAAATGA TGGTGGTTGC GCCCGATGAC GACAAAATGG ACGTGGAAGT1101 TTTGGTATTG AACAAAGACA TCGGTTTTGT GGAACAGGGA CAGGATGCGG 1151TGGTGAAGAT TGAGAGTTTT CCCTATACGC GCTACGGTTA TCTGACGGGC 1201 AAGGTGAAAAGTGTCAGCCA TGATGCGGTA AGCCACGAAC AGTTGGGCTT 1251 GGTTTATACG GCGGTGGTGTCGCTGGACAA ACATACCTTG AATATTGACG 1301 GCAAAThis corresponds to the amino acid sequence <SEQ ID 2622; ORF 764.a>:

a764.pep (partial) 1 MFFSALKSFL SRYITVWRNV WAVRDQLEPP KRTAEEQAFLPAHLELTDTP 51 VSAAPKWAAR FIMAFALLAL LWSWFGKIDI VAAASGKTVS GGRSKTIQPL 101ETVVVKAVHV RDGQHVKQGE TLAELEAVGT DSDVVQSEQA LQAAQLSKLR 151 YEAVLAALESRTVPHIDMAQ ARSLGLSDAD VQSAQVLAQH QYQAWAAQDA 201 QLQSALRGHQ AELQSAKAQEQKLVSVGAIE QQKTADYRRL RADNFISEHA 251 FLEQQSKSVS NWNDLESTRG QMRQIQAAIAQAEQNRVLNT QNLKRDTLDA 301 LRQANEQIDQ YRGQTDKAKQ RQQLMTIQSP ADGTVQELATYTVGGVVQAA 351 QKMMVVAPDD DKMDVEVLVL NKDIGFVEQG QDAVVKIESF PYTRYGYLTG401 KVKSVSHDAV SHEQLGLVYT AVVSLDKHTL NIDGK m764/a764 99.3% identity in435 aa overlap        10        20        30        40        50        60 m764.pepMFFSALKSFLSRYITVWRNVWAVRDQLKPPKRTAEEQAFLPAHLELTDTPVSAAPKWAAR|||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||| a764MFFSALKSFLSRYITVWRNVWAVRDQLEPPKRTAEEQAFLPAHLELTDTPVSAAPKWAAR        10        20        30        40        50        60        70        80        90       100       110       120 m764.pepFIMAFALLALLWSWFGKIDIVAAASGKTVSGGRSKTIQPLETAVVKAVHVRDGQHVKQGE||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||| a764FIMAFALLALLWSWFGKIDIVAAASGKTVSGGRSKTIQPLETVVVKAVHVRDGQHVKQGE        70        80        90       100       110       120       130       140       150       160       170       180 m764.pepTLAELEAVGTDSDVVQSEQALQAAQLSKLRYEAVLAALESRTVPHIDMAQARSLGLSDAD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a764TLAELEAVGTDSDVVQSEQALQAAQLSKLRYEAVLAALESRTVPHIDMAQARSLGLSDAD       130       140       150       160       170       180       190       200       210       220       230       240 m764.pepVQSAQVLAQHQYQAWAAQDAQLQSALRGHQAELQSAKAQEQKLVSVGAIEQQKTADYRRL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a764VQSAQVLAQHQYQAWAAQDAQLQSALRGHQAELQSAKAQEQKLVSVGAIEQQKTADYRRL       190       200       210       220       230       240       250       260       270       280       290       300 m764.pepRADNFISEHAFLEQQSKSVSNWNDLESTRGQMRQIQAAIAQAEQNRVLNTQNLKRDTLDA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a764RADNFISEHAFLEQQSKSVSNWNDLESTRGQMRQIQAAIAQAEQNRVLNTQNLKRDTLDA       250       260       270       280       290       300       310       320       330       340       350       360 m764.pepLRQANEQIDQYRGQTDKAKQRQQLMTIQSPADGTVQELATYTVGGVVQAAQKMMVIAPDD|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||| a764LRQANEQIDQYRGQTDKAKQRQQLMTIQSPADGTVQELATYTVGGVVQAAQKMMVVAPDD       310       320       330       340       350       360       370       380       390       400       410       420 m764.pepDKMDVEVLVLNKDIGFVEQGQDAVVKIESFPYTRYGYLTGKVKSVSHDAVSHEQLGLVYT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a764DKMDVEVLVLNKDIGFVEQGQDAVVKIESFPYTRYGYLTGKVKSVSHDAVSHEQLGLVYT       370       380       390       400       410       420       430       440       450       460       470 m764.pepAVVSLDKHTLNIDGKAVNLTAGMNVTAEIKTGKRRVLDYLLSPLQTKLDESFRERX |||||||||||||||a764 AVVSLDKHTLNIDGK        430

g765.seq not yet found

g765.pep not yet found

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2623>:

m765.seq 1 ATGTTAAGAT GCCGTCCGAA ATCCGTTTTG GATTCAGACG GCATTTTTTT 51GAAATTTAAT TTTTTAAGGA GTAAACCTAA ATATGAAATT TCCTTCCTTC 101 CTTCCTTTAAACGGATACTC TGCCTGTCGG CAGTAATCTC GGTATTGGGG 151 GCTTGTGCGG TCGTTGCTGATGTTTACGGT CATGATTCCG CCACAATGAA 201 CGCTGCGGCT GCCAAAGATT ATATGAAAACGGTTGAGTTA AACAAGTCTG 251 CCGGCAATGT CGATACCACA TCCAGAACAG CCCGCAGGGTGCAGGCAGTA 301 TTTCGACGTA TGCTGCCTTA TGCCGATGCG GCAAATAATA CCAGCCATAA351 GTTTGACTGG AAAATGACGG TTTTCAAAAA CGATGAGCTG AACGCGTGGG 401CAATGCCCGG TGGAAAAATG GCGTTTTATA CGGGGATAGT CGACAAACTC 451 AAGCTGACCGATGACGAAAT TGCCGCCATT ATGGGGCATG AAATGACGCA 501 CGCCCTGCAT GAACACGGTAAAAATAAGGT CGGGCAGCAA ATCTTGACCA 551 ATACGGCGGC GCAGATAGGC ACGCAGATTATATTAGACAA AAAACCGGAT 601 ACTAATCCGG AATTGGTCGG ATTGGGTATG GATATTTTGGGGACGTACGG 651 TCTTACCTTG CCTTATAGCC GCAGCTTGGA AGAAGAAGCC GATGAGGGGG701 GAATGATGTT GATGGCGCAG GCAGGCTATC ATCCGGCGGC CGCTGTCAGG 751GTTTGGGAAA AAATGAATCA GGAAAACGAC CAAAACGGCT TTATTTATGC 801 TATTACCTCTACTCATCCGA CAAACAATGC CCGTATAGAA AATCTAAAAC 851 GGTTGTTGCC GACCGTTATGCCGGTTTATG AGCAAAGTGT CAGAAATAAG 901 GGGCGCGTTA ATAAAAAACG TCGGCGTTAAThis corresponds to the amino acid sequence <SEQ ID 2624; ORF 765>:

m765.pep 1 MLRCRPKSVL DSDGIFLKFN FLRSKPKYEI SFLPSFKRIL CLSAVISVLG 51ACAVVADVYG HDSATMNAAA AKDYMKTVEL NKSAGNVDTT SRTARRVQAV 101 FRRMLPYADAANNTSHKFDW KMTVFKNDEL NAWAMPGGKM AFYTGIVDKL 151 KLTDDEIAAI MGHEMTHALHEHGKNKVGQQ ILTNTAAQIG TQIILDKKPD 201 TNPELVGLGM DILGTYGLTL PYSRSLEEEADEGGMMLMAQ AGYHPAAAVR 251 VWEKMNQEND QNGFIYAITS THPTNNARIE NLKRLLPTVMPVYEQSVRNK 301 GRVNKKRRR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2625>:

a765.seq 1 ATGTTAAGAT GCCGTCCGAA ATCCGTTTTG GATTCAGACG GCATTTTTTT 51GAAATTTAAT TTTTTAAGGA GTAAACCTAA ATATGAAATT TCCTTCCTTC 101 CTTCCTTTAAACGGATACTC TGCCTGTCGG CAGTAATCTC GGTATTGGGG 151 GCTTGTACGG TCGTTGCTGATGTTTACGGT CAGGATTCCG CCACAATGAA 201 TGCTGCGGCT GCCGAAGATT ATATGAAAACGGTTGAGTTG AACAAGTCTG 251 CCGGCAATGT CGATACTACA TCCAAAACAG CCCGTAGGGTGCAGGCAGTA 301 TTTCGACGTA TGTTGCCTTA TGCCGATGCG GCAAATAATA CCGGCCATAA351 GTTTGACTGG AAAATGACGG TTTTCAAAAA CGATGAGCTG AACGCGTGGG 401CAATGCCCGG CGGGAAAATG GCGTTTTATA CGGGGATAGT CGATAAACTT 451 AAGCTGACCGATGGCGAAAT TGCCGCCATT ATGGGGCATG AAATGACGCA 501 TGCCCTGCAT GAACACGGTAAAAATAAGGT CGGGCAGAAA ATCTTGACTA 551 ATATGGCGGC GCAGATAGGC ACGCAGATTATATTAGACAA AAAACCGGAC 601 ACTAATCCGG AATTGGTCGG ATTGGGTATG GATATTTTGGGGATGTACGG 651 CATTACCTTG CCTTATAGCC GCAGCTTGGA AGAAGAAGCC GATGAGGGGG701 GAATGATGTT GATGGCGCAG GCAGGCTATC ATCCGGCAGC CGCTGTCAGG 751GTTTGGGAAA AAATGAATCA GGAAAACGAC CAAAACGGCT TTATTTATGC 801 TATTACCTCTACTCATCCGA CAAACAATGC CCGTATAGAA AATCTAAAAC 851 GGTTGTTGCC GACCGTTATGCCGGTTTATG AGCACAGTGT TAGAAATAAG 901 GGGCGCGTTA ATAAAAACCG TCGGCGTTAAThis corresponds to the amino acid sequence <SEQ ID 2626; ORF 765.a>:

a765.pep 1 MLRCRPKSVL DSDGIFLKFN FLRSKPKYEI SFLPSFKRIL CLSAVISVLG 51ACTVVADVYG QDSATMNAAA AEDYMKTVEL NKSAGNVDTT SKTARRVQAV 101 FRRMLPYADAANNTGHKFDW KMTVFKNDEL NAWAMPGGKM AFYTGIVDKL 151 KLTDGEIAAI MGHEMTHALHEHGKNKVGQK ILTNMAAQIG TQIILDKKPD 201 TNPELVGLGM DILGMYGITL PYSRSLEEEADEGGMMLMAQ AGYHPAAAVR 251 VWEKMNQEND QNGFIYAITS THPTNNARIE NLKRLLPTVMPVYEHSVRNK 301 GRVNKNRRR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N meningitidisORF 765 shows 96.18% identity over a 309 aa overlap with a predicted ORF(ORF 765) from N. meningitidis:

m765/a765 96.1% identity in 309 aa overlap        10        20        30        40        50        60 m765.pepMLRCRPKSVLDSDGIFLKFNFLRSKPKYEISFLPSFKRILCLSAVISVLGACAVVADVYG||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||| a765MLRCRPKSVLDSDGIFLKFNFLRSKPKYEISFLPSFKRILCLSAVISVLGACTVVADVYG        10        20        30        40        50        60        70        80        90       100       110       120 m765.pepHDSATMNAAAAKDYMKTVELNKSAGNVDTTSRTARRVQAVFRRMLPYADAANNTSHKFDW:||||||||||:|||||||||||||||||||:||||||||||||||||||||||:||||| a765QDSATMNAAAAEDYMKTVELNKSAGNVDTTSKTARRVQAVFRRMLPYADAANNTGHKFDW        70        80        90       100       110       120       130       140       150       160       170       180 m765.pepKMTVFKNDELNAWAMPGGKMAFYLGIVDKLKLTDDEIAAIMGHEMTHALHEHGKNKVGQQ|||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||: a765KMTVFKNDELNAWAMPGGKMAFYLGIVDKLKLTDGEIAAIMGHEMTHALHEHGKNKVGQK       130       140       150       160       170       180       190       200       210       220       230       240 m765.pepILTNTAAQIGTQIILDKKPDTNPELVGLGMDILGTYGLTLPYSRSLEEEADEGGMMLMAQ|||| ||||||||||||||||||||||||||||| ||:|||||||||||||||||||||| a765ILTNMAAQIGTQIILDKKPDTNPELVGLGMDILGMYGITLPYSRSLEEEADEGGMMLMAQ       190       200       210       220       230       240       250       260       270       280       290       300 m765.pepAGYHPAAAVRVWEKMNQENDQNGFIYAITSTHPTNNARIENLKRLLPTVMPVYEQSVRNK||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| a765AGYHPAAAVRVWEKMNQENDQNGFIYAITSTHPTNNARIENLKRLLPTVMPVYEHSVRNK       250       260       270       280       290       300        310m765.pep GRVNKKRRRX |||||:|||| a765 GRVNKNRRRX        310The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2627>:

g767.seq 1 ATGAAGTTTA AACATCTGTT GCCGCTGCTG CTGTCGGCAG TGTTGTCCGC 51GCAGGCATAT GCCCTGACGG AAGGGGAAGA CTATCTTGTG TTGGATAAAC 101 CCATTCCTCAAGAACAGCCG GGAAAAATTG AGGTTTTGGA ATTTTTCGGC 151 TATTTTTGCG TACATTGCCATCATTTCGAT CCTTTGTTAT TGAAACTGGG 201 CAAGGCATTG CCGTCTGATA CTTATCTGCGGACGGAGCAC GTGGTCTGGC 251 GGCCTGAAAT GCTCGGTCTG GCAAGAATGG CTGCTGCGGTCAAGCTGTCG 301 GGTTTGAAAT ATCAGGCAAA CTCTGCTGTG TTTAAAGCAG TTTACGAACA351 AAAAATCCGT TTGGAAAACA GGGCTGTTGC CGGGAAATGG GCTTTATCTC 401AAAAAGGTTT TGACGGCAAA AAACTGATGC GCGCCTATGA TTCCCCCGAA 451 GCTGCCGCCGTCGCATTAAA AATGCAGAAA CTGACGGAAC AATACGGTAT 501 TGACAGCACG CCGACCGTTATTGTCGGCGG AAAATACCGC GTTATCTTCA 551 ATAATGGCTT TGATGGCGGC GTTCATACGATTAAAGAATT GGTTGCCAAA 601 GTCAGGGAAG AACGCAAGCG TCAGACCCCT GCTGTACAGAAATAGThis corresponds to the amino acid sequence <SEQ ID 2628; ORF 767.ng>:

g767.pep 1 MKFKHLLPLL LSAVLSAQAY ALTEGEDYLV LDKPIPQEQP GKIEVLEFFG 51YFCVHCHHFD PLLLKLGKAL PSDTYLRTEH VVWRPEMLGL ARMAAAVKLS 101 GLKYQANSAVFKAVYEQKIR LENRAVAGKW ALSQKGFDGK KLMRAYDSPE 151 AAAVALKMQK LTEQYGIDSTPTVIVGGKYR VIFNNGFDGG VHTIKELVAK 201 VREERKRQTP AVQK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2629>:

m767.seq 1 ATGAAGCTCA AACATCTGTT GCCGCTGCTG CTGTCGGCAG TGTTGTCCGC 51GCAGGCATAT GCCCTGACGG AAGGGGAAGA CTATCTTGTG TTGGATAAAC 101 CCATTCCTCAAGAACAGTCG GGTAAAATTG AGGTTTTGGA ATTTTTCGGC 151 TATTTCTGCG TACATTGCCATCATTTCGAT CCTTTGTTAT TGAAACTGGG 201 CAAGGCATTG CCGTCTGATG CCTATTTGAGGACGGAGCAC GTGGTCTGGC 251 AGCCTGAAAT GCTCGGTTTG GCTAGGATGG CGGCTGCCGTCAATTTGTCG 301 GGTTTGAAAT ATCAGGCAAA CCCTGCTGTG TTTAAAGCAG TTTACGAACA351 AAAAATCCGC TTGGAAAACA GGTCGGTTGC CGGAAAATGG GCTTTGTCTC 401AAAAAGGCTT TGACGGCAAA AAACTGATGC GCGCCTATGA TTCCCCCGAA 451 GCTGCCGCCGCCGCATTAAA AATGCAGAAA CTGACGGAAC AATACCGCAT 501 CGACAGCACG CCGACCGTTATTGTCGGCGG AAAATACCGC GTTATCTTCA 551 ATAACGGCTT TGACGGCGGC GTTCATACGATTAAAGAATT GGTTGCCAAA 601 GTCAGGGAAG AACGCAAGCG TCAGACCCCT GCTGTACAGAAATAGThis corresponds to the amino acid sequence <SEQ ID 2630; ORF 767>:

m767.pep 1 MKLKHLLPLL LSAVLSAQAY ALTEGEDYLV LDKPIPQEQS GKIEVLEFFG 51YFCVHCHHFD PLLLKLGKAL PSDAYLRTEH VVWQPEMLGL ARMAAAVNLS 101 GLKYQANPAVFKAVYEQKIR LENRSVAGKW ALSQKGFDGK KLMRAYDSPE 151 AAAAALKMQK LTEQYRIDSTPTVIVGGKYR VIFNNGFDGG VHTIKELVAK 201 VREERKRQTP AVQK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 767 shows 95.8% identity over a 214 aa overlap with a predicted ORF(ORF 767) from N. gonorrhoeae

m767/g767 95.8% identity in 214 aa overlap        10        20        30        40        50        60 g767.pepMKFKHLLPLLLSAVLSAQAYALTEGEDYLVLDKPIPQEQPGKIEVLEFFGYFCVHCHHFD||:|||||||||||||||||||||||||||||||||||| |||||||||||||||||||| m767MKLKHLLPLLLSAVLSAQAYALTEGEDYLVLDKPIPQEQSGKIEVLEFFGYFCVHCHHFD        10        20        30        40        50        60        70        80        90       100       110       120 g767.pepPLLLKLGKALPSDTYLRTEHVVWRPEMLGLARMAAAVKLSGLKYQANSAVFKAVYEQKIR|||||||||||||:|||||||||:|||||||||||||:||||||||| |||||||||||| m767PLLLKLGKALPSDAYLRTEHVVWQPEMLGLARMAAAVNLSGLKYQANPAVFKAVYEQKIR        70        80        90       100       110       120       130       140       150       160       170       180 g767.pepLENRAVAGKWALSQKGFDGKKLMRAYDSPEAAAVALKMQKLTEQYGIDSTPTVIVGGKYR||||:||||||||||||||||||||||||||||:||||||||||| |||||||||||||| m767LENRSVAGKWALSQKGFDGKKLMRAYDSPEAAAAALKMQKLTEQYRIDSTPTVIVGGKYR       130       140       150       160       170       180       190       200       210 g767.pepVIFNNGFDGGVHTIKELVAKVREERKRQTPAVQKX |||||||||||||||||||||||||||||||||||m767 VIFNNGFDGGVHTIKELVAKVREERKRQTPAVQKX        190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2631>:

a767.seq 1 ATGAAGCTCA AACATCTGTT GCCGCTGCTG CTGTCGGCAG TGTTGTCCGC 51GCAGGCATAT GCCCTGACGG AAGGGGAAGA CTATCTTGTG TTGGATAAAC 101 CCATTCCTCAAAAACAGTCG GGCAAAATTG AGGTTTTGGA ATTTTTCGGC 151 TATTTCTGCG TACATTGCCATCATTTCGAT CCTTTGTTAT TGAAATTGGG 201 CAAGGCATTG CCGTCTGATG CCTATTTAAGGACGGAGCAC GTGGTCTGGC 251 AGCCTGAAAT GCTCGGTCTG GCAAGAATGG CTGCTGCGGTCAAGCTGTCA 301 GGTTTGAAAT ATCAGGCAAA CCCTGCCGTG TTTAAAGCAG TTTACGAACA351 AAAAATCCGC TTGGAAAACA GGTCGGTTGC CGAAAAATGG GCTTTGTCTC 401AAAAAGGCTT TGACGGCAAA AAACTGATGC GCGCCTACGA CTCTCCTGCG 451 GCAGCGGCTGCTGCATCAAA AATGCAGCAA TTGACGGAAC AGTACCGCAT 501 CGACAGTACG CCGACCGTTGTCGTCGGCGG AAAATACCGC GTTATCTTCA 551 ATAATGGCTT TGACGGCGGT GTTCATACGATTAAAGAATT GGTTGCCAAA 601 GTCAGGGAAG AACGCAAGCG TCAGACCCCT GCTGTACAGAAATAGThis corresponds to the amino acid sequence <SEQ ID 2632; ORF 767.a>:

a767.pep 1 MKLKHLLPLL LSAVLSAQAY ALTEGEDYLV LDKPIPQKQS GKIEVLEFFG 51YFCVHCHHFD PLLLKLGKAL PSDAYLRTEH VVWQPEMLGL ARMAAAVKLS 101 GLKYQANPAVFKAVYEQKIR LENRSVAEKW ALSQKGFDGK KLMRAYDSPA 151 AAAAASKMQQ LTEQYRIDSTPTVVVGGKYR VIFNNGFDGG VHTIKELVAK 201 VREERKRQTP AVQK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 767 shows 96.7% identity over a 214 aa overlap with a predicted ORF(ORF 767) from N. meningitidis:

m767/a767 96.7% identity in 214 aa overlap        10        20        30        40        50        60 a767.pepMKLKHLLPLLLSAVLSAQAYALTEGEDYLVLDKPIPQKQSGKIEVLEFFGYFCVHCHHFD|||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||| m767MKLKHLLPLLLSAVLSAQAYALTEGEDYLVLDKPIPQEQSGKIEVLEFFGYFCVHCHHFD        10        20        30        40        50        60        70        80        90       100       110       120 a767.pepPLLLKLGKALPSDAYLRTEHVVWQPEMLGLARMAAAVKLSGLKYQANPAVFKAVYEQKIR|||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||| m767PLLLKLGKALPSDAYLRTEHVVWQPEMLGLARMAAAVNLSGLKYQANPAVFKAVYEQKIR        70        80        90       100       110       120       130       140       150       160       170       180 a767.pepLENRSVAEKWALSQKGFDGKKLMRAYDSPAAAAAASKMQQLTEQYRIDSTPTVVVGGKYR||||||| ||||||||||||||||||||| ||||| |||:|||||||||||||:|||||| m767LENRSVAGKWALSQKGFDGKKLMRAYDSPEAAAAALKMQKLTEQYRIDSTPTVIVGGKYR       130       140       150       160       170       180       190       200       210 a767.pepVIFNNGFDGGVHTIKELVAKVREERKRQTPAVQKX |||||||||||||||||||||||||||||||||||m767 VIFNNGFDGGVHTIKELVAKVREERKRQTPAVQKX        190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2633>:

g768.seq 1 ATGAATATCA AACAATTGAT TACCGCCGCA CTCATTGCCT CAGCCGCCTT 51TGCCACGCAG GCAGCCCCGC AAAAACCCGT ATCCGCCGCC CAAACCGCGC 101 AACATTCAGCCGTTTGGATC GATGTCCGTT CCGAACAGGA ATTTAGCGAA 151 GGTCATTTGC ACAACGCGGTCAACATCCCC GTCGACCAAA TCGTCCGCCG 201 CATATACGAA GCCGCGCCCG ACAAAGACACGCCGGTCAAC CTCTACTGCC 251 GCAGCGGACG GCGTGCCGAA GCCGCCCTTC AAGAGCTGAAAAAAGCAGGT 301 TATACAAATG TTGCCAATCA CGGCGGTTAT GAAGACCTGC TCAAAAAAGG351 GATGAAATGAThis corresponds to the amino acid sequence <SEQ ID 2634; ORF 768.ng>:

g768.pep 1 MNIKQLITAA LIASAAFATQ AAPQKPVSAA QTAQHSAVWI DVRSEQEFSE 51GHLHNAVNIP VDQIVRRIYE AAPDKDTPVN LYCRSGRRAE AALQELKKAG 101 YTNVANHGGYEDLLKKGMK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2635>:

m768.seq 1 ATGAATATCA AACACCTGAT TACCGCCGCA CTCATTGCCT CAGCCGCCTT 51TGCCGCGCAG GCAGCCCCGC AAAAACCCGT ATCCGCCGCC CAAACCGCGC 101 AACATCCGGCCGTTTGGATC GATGTCCGTT CCGAACAGGA ATTTAGCGAA 151 GGGCATTTGC ACAACGCGGTCAACATCCCC GTCGACCAAA TCGTCCGCCG 201 CATACACGAA GCCGCGCCCG ACAAAGACACGCCGGTCAAC CTCTACTGCC 251 GCAGCGGACG GCGTGCCGAA GCCGCCCTTC AAGAGCTGAAAAAAGCAGGT 301 TATACAAATG TTGCCAATCA CGGCGGTTAT GAAGACCTGC TCAAAAAAGG351 GATGAAATGAThis corresponds to the amino acid sequence <SEQ ID 2636; ORF 768>:

m768.pep 1 MNIKHLITAA LIASAAFAAQ AAPQKPVSAA QTAQHPAVWI DVRSEQEFSE 51GHLHNAVNIP VDQIVRRIHE AAPDKDTPVN LYCRSGRRAE AALQELKKAG 101 YTNVANHGGYEDLLKKGMK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 768 shows 96.6% identity over a 119 aa overlap with a predicted ORF(ORF 768) from N. gonorrhoeae

m768/g768 96.6% identity in 119 aa overlap        10        20        30        40        50        60 g768.pepMNIKQLITAALIASAAFATQAAPQKPVSAAQTAQHSAVWIDVRSEQEFSEGHLHNAVNIP||||:|||||||||||||:|||||||||||||||| |||||||||||||||||||||||| m768MNIKHLITAALIASAAFAAQAAPQKPVSAAQTAQHPAVWIDVRSEQEFSEGHLHNAVNIP        10        20        30        40        50        60        70        80        90       100       110       120 g768.pepVDQIVRRIYEAAPDKDTPVNLYCRSGRRAEAALQELKKAGYTNVANHGGYEDLLKKGMKX||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||| m768VDQIVRRIHEAAPDKDTPVNLYCRSGRRAEAALQELKKAGYTNVANHGGYEDLLKKGMKX        70        80        90       100       110       120The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2637>:

a768.seq 1 ATGAATATCA AACACCTGAT TACCGCCGCA CTCATTGCCT CAGCCGCCTT 51TGCCGCGCAG GCAGCCCCGC AAAAACCCGT ATCCGCCGCC CAAACCGCGC 101 AACATTCAGCCGTTTGGATC GATGTCCGCA GCGAACAGGA ATTTAGCGAA 151 GGTCATTTGC ACAACGCGGTCAACATCCCC GTCGACCAAA TCGTCCGCCG 201 CATACACGAA GCCGCGCCCG ACAAAGACACGCCGGTCAAC CTCTACTGCC 251 GCAGCGGACG GCGTGCCGAA GCCGCCCTTC AAGAACTGAAAAAAGCAGGC 301 TATACGAATG TTGCCAATCA CGGCGGTTAT GAAGACCTGC TCAAAAAAGG351 GATGAAATGAThis corresponds to the amino acid sequence <SEQ ID 2638; ORF 768.a>:

a768.pep 1 MNIKHLITAA LIASAAFAAQ AAPQKPVSAA QTAQHSAVWI DVRSEQEFSE 51GHLHNAVNIP VDQIVRRIHE AAPDKDTPVN LYCRSGRRAE AALQELKKAG 101 YTNVANHGGYEDLLKKGMK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N meningitidisORF 768 shows 99.2% identity over a 119 aa overlap with a predicted ORF(ORF 768) from N. meningitidis:

m768/a768 99.2% identity in 119 aa overlap        10        20        30        40        50        60 a768.pepMNIKHLITAALIASAAFAAQAAPQKPVSAAQTAQHSAVWIDVRSEQEFSEGHLHNAVNIP||||||||||||||||||||||||||||||||||| |||||||||||||||||||||||| m768MNIKHLITAALIASAAFAAQAAPQKPVSAAQTAQHPAVWIDVRSEQEFSEGHLHNAVNIP        10        20        30        40        50        60        70        80        90       100       110       120 a768.pepVDQIVRRIHEAAPDKDTPVNLYCRSGRRAEAALQELKKAGYTNVANHGGYEDLLKKGMKX|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m768VDQIVRRIHEAAPDKDTPVNLYCRSGRRAEAALQELKKAGYTNVANHGGYEDLLKKGMKX        70        80        90       100       110       120The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2639>:

g769.seq 1 TTGATAATGG TTATTTTTTA TTTTTATTTT TGTGGGAAGA CATTTATGCC 51TGCACGAAAC AGATGGATGC TGCTGCCTTT ATTGGCAAGC GCGGCATACG 101 CCGAAgaAACACCgtgCGAA CCGGATTTGA GAAGCCGTCC CGAGTTCAGG 151 CTTCATGAAG CGGAGGTCAAACCGATCGAC AGGGAGAAGG TACCGGGGCA 201 GGTGCGGGAA AAAGGAAAAG TTTTGCAGGTTGACGgcGAA ACCCTGCTGA 251 AAAATCCCGA ATTGTTGTCG CGTGCCATGT ATTCCGCAGTGGTCTCAAAC 301 AATATTGCCG GTATCCGCGT GATTTTGCCG ATTTACCTAC AACAGGCGCG351 GCAGGATAAG ATGTTGGCAC TTTATGCACA AGGGATTTTG GCGCAGGCAG 401AGGGCAGGGT GAAGGAGGCG GTTTCCCATT ACCGGGAATT GATTGCCGCC 451 CAACCCGACGCGCCCGCCGT CCGTATGCGT TTGGCGGCGG CATTGTTTGA 501 AGACAGGCAG AACGAGGCGGCGGCAGACCA GTTCGACCGC CTGAAAACAG 551 AAGATCTGCC GCCGCAGCTT ATGGAGCAGGTCGAGCTGTA CCGCAAGGCA 601 TTGCGCGAAC GCGATGCGTG GAAGGTAAAC GGCGGTTTCAGCGTTACCCG 651 CGAACACAAT ATCAACCAAG CCCCGAAACA GCAGCAGTAC GGCAATTGGA701 CTTTCCCGAA ACAGGTGGAC GGCACGGCAG TCAATTACCG GTTCGGCGCG 751GAGAAAAAAT GGTCGCTGAA AAACGGCTGG TACACGACGG CGGGCGGCGA 801 CGTGTCCGGCAGGGTTTATC CGGGGAATAA GAAATTCAAC GATATGACGG 851 CAGGTGTTTC CGGCGGCATCGGTTTTGCCG ACCGGCGTAA AGATGTCGGG 901 CTGGCAGTGT TCCACGAACG CCGCACCTACGGCAACGACG CTTATTCTTA 951 CGCCAACGGC GCACGCCTTT ATTTCAACCG TTGGCAAACCCCGAGATGGC 1001 AAACGCTGTC TTCGGCGGAG TGGGGGCGTT TGAAGAATAC GCGCCGGGCG1051 CGTTCCGACA ATACCCATTT GCAAATTTCC AATTCGCTGG TGTTTTACCG 1101GAATGCGCGC CAATATTGGA CGGGCGGTTT GGATTTTTAC CGCGAGCGCA 1151 ACCCCGCCGACCGTGGCGAC AATTTCAACC GTTACGGCCT GCGCTTTGCC 1201 TGGGGGCAGG AATGGGGCGGCAGCGGCCTG TCTTCGCTGT TCCGCCTCGG 1251 CGTGGCGAAA CGGCATTATG AAAAACCCGGCTTCTTCAGC AGTTTTAAAG 1301 GGGAAAGGCG CAGGGATAAA GAATCGGACA CATCCTTGAGCCTTTGGCAC 1351 CGGGCATTGC ATTTCAAAGG CATCACGCCG CGCCTGACGC TGTCGCACCG1401 CGAAACGTGG AGCAACGATG TGTTTAACGA ATACGAGAAA AACAGGGCGT 1451TTGTCGAGTT TAACAAAACG TTCTGAThis corresponds to the amino acid sequence <SEQ ID 2640; ORF 769.ng>:

g769.pep 1 LIMVIFYFYF CGKTFMPARN RWMLLPLLAS AAYAEETPCE PDLRSRPEFR 51LHEAEVKPID REKVPGQVRE KGKVLQVDGE TLLKNPELLS RAMYSAVVSN 101 NIAGIRVILPIYLQQARQDK MLALYAQGIL AQAEGRVKEA VSHYRELIAA 151 QPDAPAVRMR LAAALFEDRQNEAAADQFDR LKTEDLPPQL MEQVELYRKA 201 LRERDAWKVN GGFSVTREHN INQAPKQQQYGNWTFPKQVD GTAVNYRFGA 251 EKKWSLKNGW YTTAGGDVSG RVYPGNKKFN DMTAGVSGGIGFADRRKDVG 301 LAVFHERRTY GNDAYSYANG ARLYFNRWQT PRWQTLSSAE WGRLKNTRRA351 RSDNTHLQIS NSLVFYRNAR QYWTGGLDFY RERNPADRGD NFNRYGLRFA 401WGQEWGGSGL SSLFRLGVAK RHYEKPGFFS SFKGERRRDK ESDTSLSLWH 451 RALHFKGITPRLTLSHRETW SNDVFNEYEK NRAFVEFNKT F*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2641>:

m769.seq 1 TTGATAATGG TTATTTTTTA TTTTTGTGGG AAGACATTTA TGCCTGCACG 51AAACAGATGG ATGCTGCTGC TGCCTTTATT GGCAAGCGCG GCATATGCCG 101 AAGAAACACCGCGCGAACCG GATTTGAGAA GCCGTCCCGA GTTCAGGCTT 151 CATGAAGCGG AGGTCAAACCGATCGACAGG GAGAAGGTGC CGGGGCAGGT 201 GCGGGAAAAA GGAAAAGTTT TGCAGATTGACGGCGAAACC CTGCTGAAAA 251 ATCCCGAATT GTTGTCCCGC GCGATGTATT CCGCAGTGGTCTCAAACAAT 301 ATTGCCGGTA TCCGCGTTAT TTTGCCGATT TACCTACAAC AGGCGCAGCA351 GGATAAGATG TTGGCACTTT ATGCACAAGG GATTTTGGCG CAGGCAGACG 401GTAGGGTGAA GGAGGCGATT TCCCATTACC GGGAATTGAT TGCCGCCCAA 451 CCCGACGCGCCCGCCGTCCG TATGCGTTTG GCGGCAGCAT TGTTTGAAAA 501 CAGGCAGAAC GAGGCGGCGGCAGACCAGTT CGACCGCCTG AAGGCGGAAA 551 ACCTGCCGCC GCAGCTGATG GAGCAGGTCGAGCTGTACCG CAAGGCATTG 601 CGCGAACGCG ATGCGTGGAA GGTAAATGGC GGCTTCAGCGTCACCCGCGA 651 ACACAATATC AACCAAGCCC CGAAACGGCA GCAGTACGGC AAATGGACTT701 TCCCGAAACA GGTGGACGGC ACGGCGGTCA ATTACCGGCT CGGCGCGGAG 751AAAAAATGGT CGCTGAAAAA CGGCTGGTAC ACGACGGCGG GCGGCGACGT 801 GTCCGGCAGGGTTTATCCGG GGAATAAGAA ATTCAACGAT ATGACGGCAG 851 GCGTTTCCGG CGGCATCGGTTTTGCCGACC GGCGCAAAGA TGCCGGGCTG 901 GCAGTGTTCC ACGAACGCCG CACCTACGGCAACGACGCTT ATTCTTACAC 951 CAACGGCGCA CGCCTTTATT TCAACCGTTG GCAAACCCCGAAATGGCAAA 1001 CGTTGTCTTC GGCGGAGTGG GGGCGTTTGA AGAATACGCG CCGGGCGCGT1051 TCCGACAATA CCCATTTGCA AATTTCCAAT TCGCTGGTGT TTTACCGGAA 1101TGCGCGCCAA TATTGGATGG GCGGTTTGGA TTTTTACCGC GAGCGCAACC 1151 CCGCCGACCGGGGCGACAAT TTCAACCGTT ACGGCCTGCG CTTTGCCTGG 1201 GGGCAGGAAT GGGGCGGCAGCGGCCTGTCT TCGCTGTTGC GCCTCGGCGC 1251 GGCGAAACGG CATTATGAAA AACCCGGCTTTTTCAGCGGT TTTAAAGGGG 1301 AAAGGCGCAG GGATAAAGAA TTGAACACAT CCTTGAGCCTTTGGCACCGG 1351 GCATTGCATT TCAAAGGCAT CACGCCGCGC CTGACGTTGT CGCACCGCGA1401 AACGCGGAGT AACGATGTGT TCAACGAATA CGAGAAAAAT CGGGCGTTTG 1451TCGAGTTTAA TAAAACGTTC TGAThis corresponds to the amino acid sequence <SEQ ID 2642; ORF 769>:

m769.pep 1 LIMVIFYFCG KTFMPARNRW MLLLPLLASA AYAEETPREP DLRSRPEFRL 51HEAEVKPIDR EKVPGQVREK GKVLQIDGET LLKNPELLSR AMYSAVVSNN 101 IAGIRVILPIYLQQAQQDKM LALYAQGILA QADGRVKEAI SHYRELIAAQ 151 PDAPAVRMRL AAALFENRQNEAAADQFDRL KAENLPPQLM EQVELYRKAL 201 RERDAWKVNG GFSVTREHNI NQAPKRQQYGKWTFPKQVDG TAVNYRLGAE 251 KKWSLKNGWY TTAGGDVSGR VYPGNKKFND MTAGVSGGIGFADRRKDAGL 301 AVFHERRTYG NDAYSYTNGA RLYFNRWQTP KWQTLSSAEW GRLKNTRRAR351 SDNTHLQISN SLVFYRNARQ YWMGGLDFYR ERNPADRGDN FNRYGLRFAW 401GQEWGGSGLS SLLRLGAAKR HYEKPGFFSG FKGERRRDKE LNTSLSLWHR 451 ALHFKGITPRLTLSHRETRS NDVFNEYEKN RAFVEFNKTF *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 769 shows 95.1% identity over a 492 aa overlap with a predicted ORF(ORF 769) from N. gonorrhoeae

m769/g769 95.1% identity in 492 aa overlap          10        20        30        40        50        59 g769.pep  LIMVIFYFYFCGKTFMPARNRWMLL-PLLASAAYAEETPCEPDLRSRPEFRLHEAEVKPI  ||||||| |||||||||||||||| ||||||||||||| |||||||||||||||||||| m769  LIMVIFY--FCGKTFMPARNRWMLLLPLLASAAYAEETPREPDLRSRPEFRLHEAEVKPI            10        20        30        40        50 60        70        80        90       100       110      119 g769.pep  DREKVPGQVREKGKVLQVDGETLLKNPELLSRAMYSAVVSNNIAGIRVILPIYLQQARQD  |||||||||||||||||:|||||||||||||||||||||||||||||||||||||||:|| m769  DREKVPGQVREKGKVLQIDGETLLKNPELLSRAMYSAVVSNNIAGIRVILPIYLQQAQQD  60        70        80        90       100       110120       130       140       150       160       170      179 g769.pep  KMLALYAQGILAQAEGRVKEAVSHYRELIAAQPDAPAVRMRLAAALFEDRQNEAAADQFD  ||||||||||||||:||||||:||||||||||||||||||||||||||:||||||||||| m769  KMLALYAQGILAQADGRVKEAISHYRELIAAQPDAPAVRMRLAAALFENRQNEAAADQFD 120       130       140       150       160       170180       190       200       210       220       230      239 g769.pep  RLKTEDLPPQLMEQVELYRKALRERDAWKVNGGFSVTREHNINQAPKQQQYGNWTFPKQV  |||:|:|||||||||||||||||||||||||||||||||||||||||:||||:||||||| m769  RLKAENLPPQLMEQVELYRKALRERDAWKVNGGFSVTREHNINQAPKRQQYGKWTFPKQV 180       190       200       210       220       230240       250       260       270       280       290      299 g769.pep  DGTAVNYRFGAEKKWSLKNGWYTTAGGDVSGRVYPGNKKFNDMTAGVSGGIGFADRRKDV  ||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||: m769  DGTAVNYRLGAEKKWSLKNGWYTTAGGDVSGRVYPGNKKFNDMTAGVSGG IGFADRRKDA 240       250       260       270       280       290300       310       320       330       340       350      359 g769.pep  GLAVFHERRTYGNDAYSYANGARLYFNRWQTPRWQTLSSAEWGRLKNTRRARSDNTHLQI  ||||||||||||||||||:|||||||||||||:||||||||||||||||||||||||||| m769  GLAVFHERRTYGNDAYSYTNGARLYFNRWQTPKWQTLSSAEWGRLKNTRRARSDNTHLQI 300       310       320       330       340       350360       370       380       390       400       410      419 g769.pep  SNSLVFYRNARQYWTGGLDFYRERNPADRGDNFNRYGLRFAWGQEWGGSGLSSLFRLGVA  |||||||||||||| |||||||||||||||||||||||||||||||||||||||:|||:| m769  SNSLVFYRNARQYWMGGLDFYRERNPADRGDNFNRYGLRFAWGQEWGGSGLSSLLRLGAA 360       370       380       390       400       410420       430       440       450       460       470      479 g769.pep  KRHYEKPGFFSSFKGERRRDKESDTSLSLWHRALHFKGITPRLTLSHRETWSNDVFNEYE  |||||||||||:|||||||||| :|||||||||||||||||||||||||| ||||||||| m769  KRHYEKPGFFSGFKGERRRDKELNTSLSLWHRALHFKGITPRLTLSHRETRSNDVFNEYE 420       430       440       450       460       470 480       490g769.pep   KNRAFVEFNKTFX   ||||||||||||| m769   KNRAFVEFNKTFX  490The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2643>:

a769.seq 1 TTGATAATGG TTATTTTTTA TTTTTGTGGG AAGACATTTA TGCCTGCACG 51AAACAGATGG ATGCTGCTGC TGCCTTTATT GGCAAGCGCG GCATATGCCG 101 AAGAAACACCGCGCGAACCG GATTTGAGAA GCCGTCCCGA GTTCAGGCTT 151 CATGAAGCGG AGGTCAAACCAATCGACAGG GAGAAGGTAC CGGGGCAGGT 201 GCGGGAAAAA GGAAAAGTTT TGCAGATTGACGGCGAAACC CTGCTGAAAA 251 ATCCCGAATT GCTGTCCCGC GCGATGTATT CCGCAGTGGTCTCAAACAAT 301 ATTGCCGGTA TCCGCGTTAT TTTGCCGATT TACCTACAAC AGGCGCAGCA351 GGATAAGATG TTGGCACTTT ATGCACAAGG GATTTTGGCG CAGGCAGACG 401GTAGGGTGAA GGAGGCGATT TCCCATTACC GGGAATTGAT TGTCGCCCAA 451 CCCGACGCGCCCGCCGTCCG TATGCGTTTG GCGGCGGCAT TGTTTGAAAA 501 CAGGCAGAAC GAGGCGGCGGCAGACCAGTT CGACCGCCTG AAGGCGGAAA 551 ACCTGCCGCC GCAGCTGATG GAGCAGGTCGAGCTGTACCG CAAGGCATTG 601 CGCGAACGCG ATGCGTGGAA GGTAAATGGC GGCTTCAGCGTTACCCGCGA 651 ACACAATATC AACCAAGCCC CGAAACGGCA GCAGTACGGC AAATGGACTT701 TCCCGAAACA GGTGGACGGC ACGGCGGTCA ATTACCGGCT CGGCGCGGAG 751AAAAAATGGT CGCTGAAAAA CGGCTGGTAC ACGACGGCGG GCGGCGACGT 801 GTCCGGCAGGGTTTATCCGG GGAATAAGAA ATTCAACGAT ATGACGGCAG 851 GCGTTTCCGG CGGCATCGGTTTTGCCGACC GGCGCAAAGA TGCCGGGCTG 901 GCAGTGTTCC ACGAACGCCG CACCTACGGCAACGACGCTT ATTCTTACAC 951 CAACGGCGCA CGCCTTTATT TCAACCGTTG GCAAACCCCGAAATGGCAAA 1001 CGTTGTCTTC GGCGGAGTGG GGGCGTTTGA AGAATACGCG CCGGGCGCGT1051 TCCGACAATA CCCATTTGCA AATTTCCAAT TCGCTGGTGT TTTACCGGAA 1101TGCGCGCCAA TATTGGATGG GCGGTTTGGA TTTTTACCGC GAGCGCAACC 1151 CCGCCGACCGGGGCGACAAT TTCAACCGTT ACGGCCTGCG CTTTGCCTGG 1201 GGGCAGGAAT GGGGCGGCAGCGGCCTGTCT TCGCTGTTGC GCCTCGGCGC 1251 GGCGAAACGG CATTATGAAA AACCCGGCTTTTTCAGCGGT TTTAAAGGGG 1301 AAAGGCGCAG GGATAAAGAA TTGAACACAT CCTTGAGCCTTTGGCACCGG 1351 GCATTGCATT TCAAAGGCAT CACGCCGCGC CTGACGTTGT CGCACCGCGA1401 AACGCGGAGT AACGATGTGT TCAACGAATA CGAGAAAAAT CGGGCGTTTG 1451TCGAGTTTAA TAAAACGTTC TGAThis corresponds to the amino acid sequence <SEQ ID 2644; ORF 769.a>:

a769.pep 1 LIMVIFYFCG KTFMPARNRW MLLLPLLASA AYAEETPREP DLRSRPEFRL 51HEAEVKPIDR EKVPGQVREK GKVLQIDGET LLKNPELLSR AMYSAVVSNN 101 IAGIRVILPIYLQQAQQDKM LALYAQGILA QADGRVKEAI SHYRELIVAQ 151 PDAPAVRMRL AAALFENRQNEAAADQFDRL KAENLPPQLM EQVELYRKAL 201 RERDAWKVNG GFSVTREHNI NQAPKRQQYGKWTFPKQVDG TAVNYRLGAE 251 KKWSLKNGWY TTAGGDVSGR VYPGNKKFND MTAGVSGGIGFADRRKDAGL 301 AVFHERRTYG NDAYSYTNGA RLYFNRWQTP KWQTLSSAEW GRLKNTRRAR351 SDNTHLQISN SLVFYRNARQ YWMGGLDFYR ERNPADRGDN FNRYGLRFAW 401GQEWGGSGLS SLLRLGAAKR HYEKPGFFSG FKGERRRDKE LNTSLSLWHR 451 ALHFKGITPRLTLSHRETRS NDVFNEYEKN RAFVEFNKTF *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 769 shows 99.8% identity over a 490 aa overlap with a predicted ORF(ORF 769) from N. meningitidis:

m769/a769 99.8% identity in 490 aa overlap        10        20        30        40        50        60 a769.pepLIMVIFYFCGKTFMPARNRWMLLLPLLASAAYAEETPREPDLRSRPEFRLHEAEVKPIDR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m769LIMVIFYFCGKTFMPARNRWMLLLPLLASAAYAEETPREPDLRSRPEFRLHEAEVKPIDR        10        20        30        40        50        60        70        80        90       100       110       120 a769.pepEKVPGQVREKGKVLQIDGETLLKNPELLSRAMYSAVVSNNIAGIRVILPIYLQQAQQDKM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m769EKVPGQVREKGKVLQIDGETLLKNPELLSRAMYSAVVSNNIAGIRVILPIYLQQAQQDKM        70        80        90       100       110       120       130       140       150       160       170       180 a769.pepLALYAQGILAQADGRVKEAISHYRELIVAQPDAPAVRMRLAAALFENRQNEAAADQFDRL|||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||| m769LALYAQGILAQADGRVKEAISHYRELIAAQPDAPAVRMRLAAALFENRQNEAAADQFDRL       130       140       150       160       170       180       190       200       210       220       230       240 a769.pepKAENLPPQLMEQVELYRKALRERDAWKVNGGFSVTREHNINQAPKRQQYGKWTFPKQVDG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m769KAENLPPQLMEQVELYRKALRERDAWKVNGGFSVTREHNINQAPKRQQYGKWTFPKQVDG       190       200       210       220       230       240       250       260       270       280       290       300 a769.pepTAVNYRLGAEKKWSLKNGWYTTAGGDVSGRVYPGNKKFNDMTAGVSGGIGFADRRKDAGL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m769TAVNYRLGAEKKWSLKNGWYTTAGGDVSGRVYPGNKKFNDMTAGVSGGIGFADRRKDAGL       250       260       270       280       290       300       310       320       330       340       350       360 a769.pepAVFHERRTYGNDAYSYTNGARLYFNRWQTPKWQTLSSAEWGRLKNTRRARSDNTHLQISN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m769AVFHERRTYGNDAYSYTNGARLYFNRWQTPKWQTLSSAEWGRLKNTRRARSDNTHLQISN       310       320       330       340       350       360       370       380       390       400       410       420 a769.pepSLVFYRNARQYWMGGLDFYRERNPADRGDNFNRYGLRFAWGQEWGGSGLSSLLRLGAAKR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m769SLVFYRNARQYWMGGLDFYRERNPADRGDNFNRYGLRFAWGQEWGGSGLSSLLRLGAAKR       370       380       390       400       410       420       430       440       450       460       470       480 a769.pepHYEKPGFFSGFKGERRRDKELNTSLSLWHRALHFKGITPRLTLSHRETRSNDVFNEYEKN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m769HYEKPGFFSGFKGERRRDKELNTSLSLWHRALHFKGITPRLTLSHRETRSNDVFNEYEKN       430       440       450       460       470       480        490a769.pep RAFVEFNKTFX ||||||||||| m769 RAFVEFNKTFX        490The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2645>:

g770.seq 1 ATGAACAGAC TGCTACTGCT GTCTGCCGCC GTCCTGCCGA CTGCCTGCGG 51CAGCGGCGAA ACCGATAAAA TCGGACGGGC AAGTACCGTT TTCAACATGT 101 TGGGCAAAAACGACCGTATC GAAGTGGAAG GATTCGACGA TCCCGACGTT 151 CAAGGGGTTG CCTGTTATATTTCGTATGCA AAAAAAGGCG GCTTGAAGGA 201 AATGGTCAAT TTGGAAGAGG ACGCGTCCGACGCATCGGTT TCGTGCGTTC 251 AGACGGCATC TTCGATTTCT TTTGACGAAA CCGCCGTGCGCAAACCGAAA 301 GAAGTTTTCA AGCGCGGTAC GGGCTTCGCG TTCAAGAGCC GGCAGATTGT351 CCGTTATTAC GACCCCAAAC GCAAAGCCTT CGCCTATTTG GTTTACAGCG 401ATAAAATCGT CCAAGGATCG CCGAAAAATT CCTTAAGCGC GGTTTCCTGT 451 TTCGGCAGCGGCATACCGCA AACCGACGGG GTGCAAGCCG ATACTTCCGG 501 CAAACTGCTT GCCGGCGCCTGCATTATTTC CAACCCGATA AAAAATCCCG 551 ACAAACGCTG AThis corresponds to the amino acid sequence <SEQ ID 2646; ORF 770.ng>:

g770.pep 1 MNRLLLLSAA VLPTACGSGE TDKIGRASTV FNMLGKNDRI EVEGFDDPDV 51QGVACYISYA KKGGLKEMVN LEEDASDASV SCVQTASSIS FDETAVRKPK 101 EVFKRGTGFAFKSRQIVRYY DPKRKAFAYL VYSDKIVQGS PKNSLSAVSC 151 FGSGIPQTDG VQADTSGKLLAGACIISNPI KNPDKR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2647>:

m770.seq 1 ATGAACAGAC TGCTACTGCT GTCTGCCGCC GTCCTGCTGA CTGCCTGCGG 51CAGCGGCGAA ACCGATAAAA TCGGACGGGC AAGTACCGTT TTCAACATAC 101 TGGGCAAAAACGACCGTATC GAAGTGGAAG GATTCGACGA TCCCGACGTT 151 CAAGGGGTTG CCTGTTATATTTCGTATGCA AAAAAAGGCG GCTTGAAGGA 201 AATGGTCAAT TTGGAAGAGG ACGCGTCCGACGCATCGGTT TCGTGCGTTC 251 AGACGGCATC TTCGATTTCT TTTGACGAAA CCGCCGTGCGCAAACCGAAA 301 GAAGTTTTCA AACACGGTGC GAGCTTCGCG TTCAAGAGCC GGCAGATTGT351 CCGTTATTAC GACCCCAAAC GCAAAACCTT CGCCTATTTG GTGTACAGCG 401ATAAAATCAT CCAAGGCTCG CCGAAAAATT CCTTAAGCGC GGTTTCCTGT 451 TTCGGCGGCGGCATACCGCA AACCGATGGG GTGCAAGCCG ATACTTCCGG 501 CAACCTGCTT GCCGGCGCCTGCATGATTTC CAACCCGATA GAAAATCTCG 551 ACAAACGCTG AThis corresponds to the amino acid sequence <SEQ ID 2648; ORF 770>:

m770.pep 1 MNRLLLLSAA VLLTACGSGE TDKIGRASTV FNILGKNDRI EVEGFDDPDV 51QGVACYISYA KKGGLKEMVN LEEDASDASV SCVQTASSIS FDETAVRKPK 101 EVFKHGASFAFKSRQIVRYY DPKRKTFAYL VYSDKIIQGS PKNSLSAVSC 151 FGGGIPQTDG VQADTSGNLLAGACMISNPI ENLDKR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 770 shows 93.5% identity over a 186 aa overlap with a predicted ORF(ORF 770) from N. gonorrhoeae

m770/g770 93.5% identity in 186 aa overlap        10        20        30        40        50        60 g770.pepMNRLLLLSAAVLPTACGSGETDKIGRASTVFNMLGKNDRIEVEGFDDPDVQGVACYISYA|||||||||||| |||||||||||||||||||:||||||||||||||||||||||||||| m770MNRLLLLSAAVLLTACGSGETDKIGRASTVFNILGKNDRIEVEGFDDPDVQGVACYISYA        10        20        30        40        50        60        70        80        90       100       110       120 g770.pepKKGGLKEMVNLEEDASDASVSCVQTASSISFDETAVRKPKEVFKRGTGFAFKSRQIVRYY||||||||||||||||||||||||||||||||||||||||||||:|::|||||||||||| m770KKGGLKEMVNLEEDASDASVSCVQTASSISFDETAVRKPKEVFKHGASFAFKSRQIVRYY        70        80        90       100       110       120       130       140       150       160       170       180 g770.pepDPKRKAFAYLVYSDKIVQGSPKNSLSAVSCFGSGIPQTDGVQADTSGKLLAGACIISNPI|||||:||||||||||:|||||||||||||||:||||||||||||||:||||||:||||| m770DPKRKTFAYLVYSDKIIQGSPKNSLSAVSCFGGGIPQTDGVQADTSGNLLAGACMISNPI       130       140       150       160       170       180 g770.pepKNPDKRX :| |||| m770 ENLDKRXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2649>:

a770.seq 1 ATGAACAGAC TGCTACTGCT GTCTGCCGCC GTCCTGCTGA CTGCCTGCGG 51CAGCGGCGAA ACCGATAAAA TCGGACGGGC AAGTACCGTT TTCAACATAC 101 TGGGCAAAAACGACCGTATC GAAGTGGAAG GATTCGACGA TCCCGACGTT 151 CAAGGGGTTG CCTGTTATATTTCGTATGCA AAAAAAGGCG GCTTGAAGGA 201 AATGGTCAAT TTGGAAGAGG ACGCGTCCGACGCATCGGTT TCGTGCGTTC 251 AGACGGCATC TTCGATTTCT TTTGACGAAA CCGCCGTGCGCAAACCGAAA 301 GAAGTTTTCA AACACGGTGC GAGCTTCGCG TTCAAGAGCC GGCAGATTGT351 CCGTTATTAC GACCCCAAAC GCAAAACCTT CGCCTATTTG GTGTACAGCG 401ATAAAATCAT CCAAGGCTCG CCGAAAAATT CCTTAAGCGC GGTTTCCTGT 451 TTCGGCGGCGGCATACCGCA AACCGATGGG GTGCAAGCCG ATACTTCCGG 501 CAACCTGCTT GCCGGCGCCTGCATGATTTC CAACCCGATA GAAAATCCCG 551 ACAAACGCTG AThis corresponds to the amino acid sequence <SEQ ID 2650; ORF 770.a>:

a770.pep 1 MNRLLLLSAA VLLTACGSGE TDKIGRASTV FNILGKNDRI EVEGFDDPDV 51QGVACYISYA KKGGLKEMVN LEEDASDASV SCVQTASSIS FDETAVRKPK 101 EVFKHGASFAFKSRQIVRYY DPKRKTFAYL VYSDKIIQGS PKNSLSAVSC 151 FGGGIPQTDG VQADTSGNLLAGACMISNPI ENPDKR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 770 shows 99.5% identity over a 186 aa overlap with a predicted ORF(ORF 770) from N. meningitidis:

m770/a770 99.5% identity in 186 aa overlap        10        20        30        40        50        60 a770.pepMNRLLLLSAAVLLTACGSGETDKIGRASTVFNILGKNDRIEVEGFDDPDVQGVACYISYA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m770MNRLLLLSAAVLLTACGSGETDKIGRASTVFNILGKNDRIEVEGFDDPDVQGVACYISYA        10        20        30        40        50        60        70        80        90       100       110       120 a770.pepKKGGLKEMVNLEEDASDASVSCVQTASSISFDETAVRKPKEVFKHGASFAFKSRQIVRYY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m770KKGGLKEMVNLEEDASDASVSCVQTASSISFDETAVRKPKEVFKHGASFAFKSRQIVRYY        70        80        90       100       110       120       130       140       150       160       170       180 a770.pepDPKRKTFAYLVYSDKIIQGSPKNSLSAVSCFGGGIPQTDGVQADTSGNLLAGACMISNPI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m770DPKRKTFAYLVYSDKIIQGSPKNSLSAVSCFGGGIPQTDGVQADTSGNLLAGACMISNPI       130       140       150       160       170       180 a770.pepENPDKRX || |||| m770 ENLDKRXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2651>:

g771.seq 1 ATGGATTTAT TATCGGTTTT CCACAAATAC CGTCTGAAAT ATGCGGTGGC 51GGTGCTGACG ATGCTGCTTT TGGCGGCAGT CGGGCTGCAC GCTTCCGTAT 101 ATCGCACCTTCACGCCCGAA AACATCCGCA GCCGCCTCCA ACAAAGCATT 151 GCCCATACCC ACCGGAAAATCTCGTTTGAT GCGGATATAC GGCGCAGGCT 201 TCTGCCCCGC CCGACCGTCA TCCTGAAAAACCTGACCATT ACCGAACCCG 251 ACGGCGGCCG GGTCGCCGTT TCCGTCAAAG AAACCAAAATCGGATTGAGC 301 TGGAAAAACC TGTGGTCGGA TCGGATACAG GTTGAAAAAT GGGTGGTTTC351 GGGTGCGGAT CTTGCCCTGA CGCGCGACAG AAACGGCGCT TGGAACATCC 401AAGACCTGTT CGACGGCGCG AAACACTCCG CCTCAGTCAA CCGCATTATC 451 GTCGAAAACAGCACCGTCCG CCTCAATTTC CTGCAGCAAC AGCTTATCCT 501 GAAGGAAATC AGCCTCAACCTGCAATCCCC CGATTCGTCG GGGCAGCAGT 551 TTGAAAGTTC GGGCATACTG GTTTGGAGAAAGCTGTCCGT CCCGTGGAAA 601 AGCAGGGGGC TGTTCCTTTC AGACGGCATC GGCACGCCCGAAATCTCACC 651 GTTCCATTTT GAAGCTTCCA CTTCGCTGGA CGGACACGGC ATCACCATTT701 CCACCACCGG CAGCCCTTCT GTCCGCTTCA ACGCCGGCGG AGCGGATGCC 751GCCGGCCTCG GCCTGCGTGC AGACACTTCC TTCCGCAACC TCCACCTGAC 801 CGCGCAAATCCCCGCACTGG CACTCAAAAA CAACAGCATC AAAACCGGCA 851 CGGTCAACGG CACGTTTACCGCCGGCGGCG AATATGCCCG ATGGGACGGT 901 TCGTTCAAAC TCGACAAAGC CAACCTGCACTCCGGCATCG CCAACATCGG 951 CAACGCCGAA ATCTCCGGCA GCTTCAAAAC ACCGCGCCTTCAAACCAATT 1001 TCTCCCTCGG CTCGCCGTTG GTTTGGAGTC GGGACAACGG GCTGGACGCC1051 CCGCGCCTGC ACATATCGAC CCTTCAGGAT ACCGTCGACC GCCTGCCGCA 1101ACCCCGTTTC ATCAGCCGGC TCGACGGTTC GCTGTCCATA CCGAATCTGC 1151 AAAATTGGAATGCCGAATTA AACGGCACAT TCGACCGCCA ACCCGTTGCC 1201 GCAAAATTCA AATATACGCGGGAAGGCGCA CCGCACCTGG AAGCCGCCGC 1251 CGCGCTGCAA AAATTAAACC TCGCCCCCTATCTTGACGAA TTTCGGCAAC 1301 AAAACGGCAA AATATTCCCC GACATCCTCG GCAGGCTGTCCGGCAACGTC 1351 GAGGCACACC TCAAAATCGG CAGCATCCAA CTCCCCGGCT TGCAACTGGA1401 CGATATGGAA ACCTACCTCC ACGCCGACAA AGACCATATC GCGCTCAGCC 1451GTTTCAAGTC AGGGCTTTAC GGCGGCCATA CCGAAGGCGG CATCAGCATC 1501 GCCAACACCCGTCCCGCCAC TTACCGCCTG CAACAGAATG CAAGCAACAT 1551 CCAAATCCAA CCGCTGCTGCAAGACCTGTT CGGCTTCCAC AGCTTCAGCG 1601 GCAACGGCGA TGCGGTCATC GACCTGACCGCAAGCGGCGA AAACCGCAAA 1651 CAGCTTATCC GCTCGCTGCA AGGCAGCCTG TCGCTGAATATTTCCAACGG 1701 CGCGTGGCAC GGCATCGATA TGGACAGCAT TTTAAAAAAC GGCCTTTCCG1751 GGAAAATCTC GGGCAGCACA CCCTTCTACC GATTCACGCT CAACAGCGAA 1801ATTTCAGACG GCATCAGCCG CCACATCGAT ACCGAACTCT TCTCCGACAG 1851 CCTCTATGTTACCAGCAACG GCTATACCAA TCTGGATACG CAGGAATTGT 1901 CTGAAGATGT CCTTATCCGCAACGCCGTCC ATCCGAAAAA CAAACCGATT 1951 CCCCTGAAAA TCACCGGTAC GGTGGACAAGCCGTCCATTA CCGTCGATTA 2001 CGGCAGGCTG ACCGGCGGCA TCAATTCGCG CAAAGAGAAACAGAAAATCC 2051 TCGAAGACAC CCTGCTGGAA CAATGGCAGT GGCTCAAACC TAAAGAACCG3051 TAAThis corresponds to the amino acid sequence <SEQ ID 2652; ORF 771.ng>:

g771.pep 1 MDLLSVFHKY RLKYAVAVLT MLLLAAVGLH ASVYRTFTPE NIRSRLQQSI 51AHTHRKISFD ADIRRRLLPR PTVILKNLTI TEPDGGRVAV SVKETKIGLS 101 WKNLWSDRIQVEKWVVSGAD LALTRDRNGA WNIQDLFDGA KHSASVNRII 151 VENSTVRLNF LQQQLILKEISLNLQSPDSS GQQFESSGIL VWRKLSVPWK 201 SRGLFLSDGI GTPEISPFHF EASTSLDGHGITISTTGSPS VRFNAGGADA 251 AGLGLRADTS FRNLHLTAQI PALALKNNSI KTGTVNGTFTAGGEYARWDG 301 SFKLDKANLH SGIANIGNAE ISGSFKTPRL QTNFSLGSPL VWSRDNGLDA351 PRLHISTLQD TVDRLPQPRF ISRLDGSLSI PNLQNWNAEL NGTFDRQPVA 401AKFKYTREGA PHLEAAAALQ KLNLAPYLDE FRQQNGKIFP DILGRLSGNV 451 EAHLKIGSIQLPGLQLDDME TYLHADKDHI ALSRFKSGLY GGHTEGGISI 501 ANTRPATYRL QQNASNIQIQPLLQDLFGFH SFSGNGDAVI DLTASGENRK 551 QLIRSLQGSL SLNISNGAWH GIDMDSILKNGLSGKISGST PFYRFTLNSE 601 ISDGISRHID TELFSDSLYV TSNGYTNLDT QELSEDVLIRNAVHPKNKPI 651 PLKITGTVDK PSITVDYGRL TGGINSRKEK QKILEDTLLE QWQWLKPKEP701 *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2653>:

m771.seq 1 ATGGATTTAT TATCGGTTTT CCACAAATAC CGTCTGAAAT ATGCGGTGGC 51CGTGCTGACG ATACTGCTTT TGGCGGCAGT CGGGCTGCAC GCTTCCGTAT 101 ATCGCACCTTCACGCCTGAA AACATCCGCA GCCGCCTACA ACAAAGCATT 151 GCACACACAC ACCGGAAAATCTCGTTTGAT GCGGACATTC AGCGCAGGCT 201 CCTGCCCCGG CCGACCGTCA TCCTGAAAAACCTGACCATT ACCGAACCCG 251 GCGGCGACCA GACTGCCGTT TCCGTCCAAG AAACCAAAATCGGATTGAGC 301 TGGAAAAACC TGTGGTCGGA TCAGATACAG ATTGAAAAAT GGGTGGTTTC351 GAGTGCGGAA CTTGCCCTGA CGCGCGACGG GAAAGGTGTT TGGAACATCC 401AAGACCTGAT CGACAGCCAA AAACGCCAAG CCTCAGTCAA CCGCATTATC 451 GTCGAAAACAGCACCGTCCG CCTCAATTTC CTGCAGGAAC AGCTTATCCT 501 GAAGGAAATC AACCTCAACCTGCAATCCCC CGATTCGTCG GGGCAGCCGT 551 TTGAAAGTTC GGGCATACTG GTTTGGGGAAAGCTGTCCGT CCCGTGGAAA 601 AGCAGGGGGC TGTTCCTTTC AAACGGCATC GGCCCGCCCGAAATCTCACC 651 GTTCCATTTT GAAGCTTCCA CTTCGCTGGA CGGACACGGC ATTACCATTT701 CCACCACCGG CAGCCCTTCT GTCCGCTTCA ACGCCGGCGG AGCGGATGCC 751GCCGGCCTCG GCCTGCGTGC AGACACTTCC TTCCGCAACC TCCACCTGAC 801 CGCCCAAATCCCCGCGCTGG CACTCAGGAA CAACAGCATT AAAATTGAAA 851 CCGTCAACGG CGCATTTACCGCCGGCGGCG AATATGCCCG ATGGGACGGT 901 TCGTTCAAAC TCGACAAAGC CAACCTGCACTCCGGCATCG CCAACATCGG 951 CAACGCCGAA ATCTCCGGCA GCTTCAAAAC ACCGCGCCACCAGACCAACT 1001 TCTCCCTCAA TTCGCCGCTC GTATGGACGG AAAACAAAGG GCTGGACGCG1051 CCGCGCCTGT ATGTATCGAC CCTTCAGGAT ACCGTCAACC GCCTGCCGCA 1101ACCCCGTTTC ATCAGCCGGC TCGACGGTTC GCTGTCCGTA CCGAATCTGC 1151 AAAATTGGAATGCCGAATTA AACGGCACAT TCGACCGCCA AACCGTTGCC 1201 GCGAAATTCA GATACACACATGAAGACGCA CCGCATCTGG AAGCCGCCGT 1251 CGCACTGCAA AAATTGAACC TGACCCCCTATCTTGACGAC GTGCGGCAAC 1301 AAAACGGCAA AATATTTCCC GACACCCTCG CCAAGCTGTCCGGCGACATC 1351 GAGGCGCACC TGAAAATCGG AAAAGTCCAA CTTCCCGGCC TGCAACTGGA1401 CGATATGGAA ACCTACCTCC ACGCCGACAA AGGCCATATC GCGCTCAGCC 1451GTTTCAAGTC AGGGCTTTAC GGCGGCCATA CCGAAGGCGG CATCAGCATC 1501 GCCAACACCCGTCCCGCCAC TTACCGCCTG CAACAGAATG CAAGCAACAT 1551 CCAAATCCAA CCGCTGCTGCAAGACCTGTT CGGCTTCCAC AGCTTCAGCG 1601 GCAACGGCGA CGCGGTCATC GACCTGACCGCGGGCGGCGA AACCCGAAAA 1651 GAGCTTATCC GCTCGCTTCA GGGCAGCCTG TCGCTAAATATTTCCAACGG 1701 TGCATGGCAC GGTATCGACA TGGACAATAT CCTGAAAAAC GGCATTTCGG1751 GCAAAACTGC CGACAATGCC GCACCCAGCA CACCCTTCCA CCGATTCACG 1801CTCAACAGCG AAATTTCAGA CGGCATCAGC CGCCACATCG ATACCGAACT 1851 CTTCTCCGACAGCCTCTATG TTACCAGCAA CGGCTATACC AATCTGGATA 1901 CGCAGGAATT GTCTGAAGATGTCCTTATCC GCAACGCCGT CCATCCGAAA 1951 AACAAACCGA TTCCCCTGAA AATCACCGGCACGGTGGACA AACCGTCCAT 2001 TACCGTCGAT TACGGCAGGC TGACCGGCGG CATCAATTCGCGCAAAGAGA 2051 AACAGAAAAT CCTCGAAGAC ACCCTGCTGG AACAATGGCA GTGGCTCAAA2101 CCTAAAGAAC CGTAThis corresponds to the amino acid sequence <SEQ ID 2654; ORF 771>:

m771.pep 1 MDLLSVFHKY RLKYAVAVLT ILLLAAVGLH ASVYRTFTPE NIRSRLQQSI 51AHTHRKISFD ADIQRRLLPR PTVILKNLTI TEPGGDQTAV SVQETKIGLS 101 WKNLWSDQIQIEKWVVSSAE LALTRDGKGV WNIQDLIDSQ KRQASVNRII 151 VENSTVRLNF LQEQLILKEINLNLQSPDSS GQPFESSGIL VWGKLSVPWK 201 SRGLFLSNGI GPPEISPFHF EASTSLDGHGITISTTGSPS VRFNAGGADA 251 AGLGLRADTS FRNLHLTAQI PALALRNNSI KIETVNGAFTAGGEYARWDG 301 SFKLDKANLH SGIANIGNAE ISGSFKTPRH QTNFSLNSPL VWTENKGLDA351 PRLYVSTLQD TVNRLPQPRF ISRLDGSLSV PNLQNWNAEL NGTFDRQTVA 401AKFRYTHEDA PHLEAAVALQ KLNLTPYLDD VRQQNGKIFP DTLAKLSGDI 451 EAHLKIGKVQLPGLQLDDME TYLHADKGHI ALSRFKSGLY GGHTEGGISI 501 ANTRPATYRL QQNASNIQIQPLLQDLFGFH SFSGNGDAVI DLTAGGETRK 551 ELIRSLQGSL SLNISNGAWH GIDMDNILKNGISGKTADNA APSTPFHRFT 601 LNSEISDGIS RHIDTELFSD SLYVTSNGYT NLDTQELSEDVLIRNAVHPK 651 NKPIPLKITG TVDKPSITVD YGRLTGGINS RKEKQKILED TLLEQWQWLK701 PKEP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 771 shows 90.3% identity over a 704 aa overlap with a predicted ORF(ORF 771) from N. gonorrhoeae

m771/g771 90.3% identity in 704 aa overlap        10        20        30        40        50        60 g771.pepMDLLSVFHKYRLKYAVAVLTMLLLAAVGLHASVYRTFTPENIRSRLQQSIAHTHRKISFD||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||| m771MDLLSVFHKYRLKYAVAVLTILLLAAVGLHASVYRTFTPENIRSRLQQSIAHTHRKISFD        10        20        30        40        50        60        70        80        90       100       110       120 g771.pepADIRRRLLPRPTVILKNLTITEPDGGRVAVSVKETKIGLSWKNLWSDRIQVEKWVVSGAD|||:||||||||||||||||||| | ::||||:||||||||||||||:||:||||||:|: m771ADIQRRLLPRPTVILKNLTITEPGGDQTAVSVQETKIGLSWKNLWSDQIQIEKWVVSSAE        70        80        90       100       110       120       130       140       150       160       170       180 g771.pepLALTRDRNGAWNIQDLFDGAKHSASVNRIIVENSTVRLNFLQQQLILKEISLNLQSPDSS|||||| :|:||||||:|: |::|||||||||||||||||||:|||||||:||||||||| m771LALTRDGKGVWNIQDLIDSQKRQASVNRIIVENSTVRLNFLQEQLILKEINLNLQSPDSS       130       140       150       160       170       180       190       200       210       220       230       240 g771.pepGQQFESSGILVWRKLSVPWKSRGLFLSDGIGTPEISPFHFEASTSLDGHGITISTTGSPS|| ||||||||| ||||||||||||||:||| |||||||||||||||||||||||||||| m771GQPFESSGILVWGKLSVPWKSRGLFLSNGIGPPEISPFHFEASTSLDGHGITISTTGSPS       190       200       210       220       230       240       250       260       270       280       290       300 g771.pepVRFNAGGADAAGLGLRADTSFRNLHLTAQIPALALKNNSIKTGTVNGTFTAGGEYARWDG|||||||||||||||||||||||||||||||||||:|||||  ||||:|||||||||||| m771VRFNAGGADAAGLGLRADTSFRNLHLTAQIPALALRNNSIKIETVNGAFTAGGEYARWDG       250       260       270       280       290       300       310       320       330       340       350       360 g771.pepSFKLDKANLHSGIANIGNAEISGSFKTPRLQTNFSLGSPLVWSRDNGLDAPRLHISTLQD||||||||||||||||||||||||||||| ||||||:|||||::::|||||||::||||| m771SFKLDKANLHSGIANIGNAEISGSFKTPRHQTNFSLNSPLVWTENKGLDAPRLYVSTLQD       310       320       330       340       350       360       370       380       390       400       410       420 g771.pepTVDRLPQPRFISRLDGSLSIPNLQNWNAELNGTFDRQPVAAKFKYTREGAPHLEAAAALQ||:||||||||||||||||:||||||||||||||||| |||||:||:| |||||||:||| m771TVNRLPQPRFISRLDGSLSVPNLQNWNAELNGTFDRQTVAAKFRYTHEDAPHLEAAVALQ       370       380       390       400       410       420       430       440       450       460       470       480 g771.pepKLNLAPYLDEFRQQNGKIFPDILGRLSGNVEAHLKIGSIQLPGLQLDDMETYLHADKDHI ||||:||||:|||||||||| |::|||::|||||||::|||||||||||||||||| || m771KLNLTPYLDDVRQQNGKIFPDTLAKLSGDIEAHLKIGKVQLPGLQLDDMETYLHADKGHI       430       440       450       460       470       480       490       500       510       520       530       540 g771.pepALSRFKSGLYGGHTEGGISIANTRPATYRLQQNASNIQIQPLLQDLFGFHSFSGNGDAVI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m771ALSRFKSGLYGGHTEGGISIANTRPATYRLQQNASNIQIQPLLQDLFGFHSFSGNGDAVI       490       500       510       520       530       540       550       560       570       580           590 g771.pepDLTASGENRKQLIRSLQGSLSLNISNGAWHGIDMDSILKNGLSGKISG----STPFYRFT||||:||:||:||||||||||||||||||||||||:|||||:||| :     ||||:||| m771DLTAGGETRKELIRSLQGSLSLNISNGAWHGIDMDNILKNGISGKTADNAAPSTPFHRFT       550       560       570       580       590       600 600       610       620       630       640       650 g771.pepLNSEISDGISRHIDTELFSDSLYVTSNGYTNLDTQELSEDVLIRNAVHPKNKPIPLKITG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m771LNSEISDGISRHIDTELFSDSLYVTSNGYTNLDTQELSEDVLIRNAVHPKNKPIPLKITG       610       620       630       640       650       660 660       670       680       690       700 g771.pepTVDKPSITVDYGRLTGGINSRKEKQKILEDTLLEQWQWLKPKEPX||||||||||||||||||||||||||||||||||||||||||||| m771TVDKPSITVDYGRLTGGINSRKEKQKILEDTLLEQWQWLKPKEPX       670       680       690       700The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2655>:

a771.seq 1 ATGGATTTAT TATCGGTCTT CCACAAATAC CGTCTGAAAT ATGCGGTAGC 51CGTGCTGACG ATACTGCTTT TGGCGGCAAT CGGGCTGCAC GCTTCCGTAT 101 ATCGCATCTTCACACCTGAA AACATCCGAA GCCGCCTCCA ACAAAGCATT 151 GCCCATACGC ACCGGAAAATCTCGTTTGAT GCGGATATAC AGCGCAGGCT 201 TCTGCCCCGG CCGACCGTCA TCCTGAAAAACCTGACCATT ACCGAACCCG 251 GCGGCGACCG GACTGCCGTT TCCGTCCAAG AAACCAAAATCGGATTGAGC 301 TGGAAAAACC TGTGGTCGGA TCAGATACAG ATTGAAAAAT GGGTGGTTTC351 GAGTGCGGAA CTTGCCCTGA CGCGCGACGG GAAAGGTGTT TGGAACATCC 401AAGACCTGAT CGACAGCCAA AAACGCCAAG CCTCAGTCAA CCGCATTATC 451 GTCGAAAACAGCACCGTCCG CCTCAATTTC CTGCAGGAAC AGCTTATCCT 501 GAAGGAAATC AACCTCAACCTGCAATCCCC CGATTCGTCG GGGCAGCCGT 551 TTGAAAGTTC GGGCATACTG GTTTGGGGAAAGCTGTCCGT CCCGTGGAAA 601 AGCAGGGGGC TGTTCCTTTC AGACGGCATC GGCACGCCCAAAATCTCACC 651 GTTCCATTTT GAAGCTTCCA CTTCGCTGGA CGGACACGGC ATTACCATTT701 CCACCACCGG CAGCCCTTCT GTCCGCTTCA ACGCCGGCGG AGCGGATGCC 751GCCGGCCTCG GCCTGCGTGC AGACACTTCC TTCCGCAACC TCCACCTGAC 801 CGCCCAAATCCCTACGCTGG CACTCAGGAA CAACAGCATT AAAATTGAAA 851 CCGTCAACGG CGCATTTACCGCCGGCGGCG AATATGCCCA ATGGGACGGT 901 TCGTTCAAAC TCGACAAAGC CAACCTGCACTCCGGCATCG CCAACATCGG 951 CAACGCCGAA ATCTCCGGCA GCTTCAAAAC ACCGCGCCACCAGACCAACT 1001 TCTCCCTCAA TTCGCCGCTC GTATGGACGG AAAACAAAGG GCTGGACGCG1051 CCGCGCCTGT ATGTATCGAC CCTTCAGGAT ACCGTCAACC GCCTGCCGCA 1101ACCCCGTTTC ATCAGCCGGC TCGACGGTTC GCTGTCCGTA CCGAATCTGC 1151 AAAATTGGAATGCCGAATTA AACGGCACAT TCGACCGCCA AACCGTTGCC 1201 GCGAAATTCA GATACACACATGAAGACGCA CCGCATCTGG AAGCCGCCGT 1251 CGCACTGCAA AAATTGAACC TGACCCCCTATCTTGACGAC GTGCGGCAAC 1301 AAAACGGCAA AATATTTCCC GACACCCTCG CCAAGCTGTCCGGCGACATC 1351 GAGGCGCACC TGAAAATCGG AAAAGTCCAA CTTCCCGGCC TGCAACTGGA1401 CGATATGGAA ACCTACCTCC ACGCCGACAA AGGCCATATC GCGCTCAGCC 1451GTTTCAAGTC AGGGCTTTAC GGCGGCCATA CCGAAGGCGG CATCAGCATC 1501 GCCAACACCCGTCCCGCCAC TTACCGCCTG CAACAGAATG CAAGCAACAT 1551 CCAAATCCAA CCGCTGCTGCAAGACCTGTT CGGCTTCCAC AGCTTCAGCG 1601 GCAACGGCGA CGCGGTCATC GACCTGACCGCGGGCGGCGA AACCCGAAAA 1651 GAGCTTATCC GCTCGCTTCA GGGCAGCCTG TCGCTAAATATTTCCAACGG 1701 TGCATGGCAC GGTATCGACA TGGACAATAT CCTGAAAAAC GGCATTTCGG1751 GCAAAACTGC CGACAATGCC GCACCCAGCA CACCCTTCCA CCGATTCACG 1801CTCAACAGCG AAATTTCAGA CGGCATCAGC CGCCACATCG ATACCGAACT 1851 CTTCTCCGACAGCCTCTATG TTACCAGCAA CGGCTATACC AATCTGGATA 1901 CGCAGGAATT GTCTGAAGATGTCCTTATCC GCAACGCCGT CCATCCGAAA 1951 AACAAACCGA TTCCCCTGAA AATCACCGGTACGGTGGACA AACCGTCCAT 2001 TACCGTCGAT TACGGCAGGC TGACCGGCGG CATCAATTCGCGCAAAGAGA 2051 AACAGAAAAT CCTCGAAGAC ACCCTGCTGG AACAATGGCA GTGGCTCAAA2101 CCTAAAGAAC CGTAAThis corresponds to the amino acid sequence <SEQ ID 2656; ORF 771.a>:

a771.pep 1 MDLLSVFHKY RLKYAVAVLT ILLLAAIGLH ASVYRIFTPE NIRSRLQQSI 51AHTHRKISFD ADIQRRLLPR PTVILKNLTI TEPGGDRTAV SVQETKIGLS 101 WKNLWSDQIQIEKWVVSSAE LALTRDGKGV WNIQDLIDSQ KRQASVNRII 151 VENSTVRLNF LQEQLILKEINLNLQSPDSS GQPFESSGIL VWGKLSVPWK 201 SRGLFLSDGI GTPKISPFHF EASTSLDGHGITISTTGSPS VRFNAGGADA 251 AGLGLRADTS FRNLHLTAQI PTLALRNNSI KIETVNGAFTAGGEYAQWDG 301 SFKLDKANLH SGIANIGNAE ISGSFKTPRH QTNFSLNSPL VWTENKGLDA351 PRLYVSTLQD TVNRLPQPRF ISRLDGSLSV PNLQNWNAEL NGTFDRQTVA 401AKFRYTHEDA PHLEAAVALQ KLNLTPYLDD VRQQNGKIFP DTLAKLSGDI 451 EAHLKIGKVQLPGLQLDDME TYLHADKGHI ALSRFKSGLY GGHTEGGISI 501 ANTRPATYRL QQNASNIQIQPLLQDLFGFH SFSGNGDAVI DLTAGGETRK 551 ELIRSLQGSL SLNISNGAWH GIDMDNILKNGISGKTADNA APSTPFHRFT 601 LNSEISDGIS RHIDTELFSD SLYVTSNGYT NLDTQELSEDVLIRNAVHPK 651 NKPIPLKITG TVDKPSITVD YGRLTGGINS RKEKQKILED TLLEQWQWLK701 PKEP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 771 shows 98.9% identity over a 704 aa overlap with a predicted ORF(ORF 771) from N. meningitidis

m771/a771 98.9% identity in 704 aa overlap        10        20        30        40        50        60 a771.pepMDLLSVFHKYRLKYAVAVLTILLLAAIGLHASVYRIFTPENIRSRLQQSIAHTHRKISFD||||||||||||||||||||||||||:|||||||| |||||||||||||||||||||||| m771MDLLSVFHKYRLKYAVAVLTILLLAAVGLHASVYRTFTPENIRSRLQQSIAHTHRKISFD        10        20        30        40        50        60        70        80        90       100       110       120 a771.pepADIQRRLLPRPTVILKNLTITEPGGDRTAVSVQETKIGLSWKNLWSDQIQIEKWVVSSAE||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| m771ADIQRRLLPRPTVILKNLTITEPGGDQTAVSVQETKIGLSWKNLWSDQIQIEKWVVSSAE        70        80        90       100       110       120       130       140       150       160       170       180 a771.pepLALTRDGKGVWNIQDLIDSQKRQASVNRIIVENSTVRLNFLQEQLILKEINLNLQSPDSS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m771LALTRDGKGVWNIQDLIDSQKRQASVNRIIVENSTVRLNFLQEQLILKEINLNLQSPDSS       130       140       150       160       170       180       190       200       210       220       230       240 a771.pepGQPFESSGILVWGKLSVPWKSRGLFLSDGIGTPKISPFHFEASTSLDGHGITISTTGSPS|||||||||||||||||||||||||||:||| |:|||||||||||||||||||||||||| m771GQPFESSGILVWGKLSVPWKSRGLFLSNGIGPPEISPFHFEASTSLDGHGITISTTGSPS       190       200       210       220       230       240       250       260       270       280       290       300 a771.pepVRFNAGGADAAGLGLRADTSFRNLHLTAQIPTLALRNNSIKIETVNGAFTAGGEYAQWDG|||||||||||||||||||||||||||||||:||||||||||||||||||||||||:||| m771VRFNAGGADAAGLGLRADTSFRNLHLTAQIPALALRNNSIKIETVNGAFTAGGEYARWDG       250       260       270       280       290       300       310       320       330       340       350       360 a771.pepSFKLDKANLHSGIANIGNAEISGSFKTPRHQTNFSLNSPLVWTENKGLDAPRLYVSTLQD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m771SFKLDKANLHSGIANIGNAEISGSFKTPRHQTNFSLNSPLVWTENKGLDAPRLYVSTLQD       310       320       330       340       350       360       370       380       390       400       410       420 a771.pepTVNRLPQPRFISRLDGSLSVPNLQNWNAELNGTFDRQTVAAKFRYTHEDAPHLEAAVALQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m771TVNRLPQPRFISRLDGSLSVPNLQNWNAELNGTFDRQTVAAKFRYTHEDAPHLEAAVALQ       370       380       390       400       410       420       430       440       450       460       470       480 a771.pepKLNLTPYLDDVRQQNGKIFPDTLAKLSGDIEAHLKIGKVQLPGLQLDDMETYLHADKGHI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m771KLNLTPYLDDVRQQNGKIFPDTLAKLSGDIEAHLKIGKVQLPGLQLDDMETYLHADKGHI       430       440       450       460       470       480       490       500       510       520       530       540 a771.pepALSRFKSGLYGGHTEGGISIANTRPATYRLQQNASNIQIQPLLQDLFGFHSFSGNGDAVI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m771ALSRFKSGLYGGHTEGGISIANTRPATYRLQQNASNIQIQPLLQDLFGFHSFSGNGDAVI       490       500       510       520       530       540       550       560       570       580       590       600 a771.pepDLTAGGETRKELIRSLQGSLSLNISNGAWHGIDMDNILKNGISGKTADNAAPSTPFHRFT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m771DLTAGGETRKELIRSLQGSLSLNISNGAWHGIDMDNILKNGISGKTADNAAPSTPFHRFT       550       560       570       580       590       600       610       620       630       640       650       660 a771.pepLNSEISDGISRHIDTELFSDSLYVTSNGYTNLDTQELSEDVLIRNAVHPKNKPIPLKITG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m771LNSEISDGISRHIDTELFSDSLYVTSNGYTNLDTQELSEDVLIRNAVHPKNKPIPLKITG       610       620       630       640       650       660       670       680       690       700 a771.pepTVDKPSITVDYGRLTGGINSRKEKQKILEDTLLEQWQWLKPKEPX||||||||||||||||||||||||||||||||||||||||||||| m771TVDKPSITVDYGRLTGGINSRKEKQKILEDTLLEQWQWLKPKEPX       670       680       690       700The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2657>:

g772.seq 1 GTGTTCGGCA CGGTCTTGCG GACTGATGCC GACTGCCTGC AAATCATCGT 51CGTCGGCAAG TTCTTTCAGG TTGTTGCGTA TGGTTTTGCG GCGTTGGCGG 101 AAGGCGAGTTTCACCAGTTT GGCGAAATGA TCGAAATCGT CCGCCTTGCC 151 GATACGGTGT TTCACCGGAATCATGCGCAC CACTGCGGAA TCGATTTTCG 201 GCGCGGGATC GAACGATTCG GGCGGCACGTCAATCAGCAG CTCCATATCG 251 AAAAAATATT GCAGCATCAC ACCCAAGCGA CCGTAGTCGTTGCTTTTCGG 301 CGCGGCAACC ATGCGCTCGA CCACTTCTTT TTGCAACATA AAGTGCATAT351 CGGCGACATC GTCCGCCACC TCCGCCAGTT TGAACAAAAG CGGCGTGGAG 401ATGTTATACG GCAGGTTGCC GACGATTTTC TTTTTGCCTG AGATGCCGTT 451 GAAATCAAACTGCAACACGT CGCCTTCGTG AATCACCAGT TTATCCGCAA 501 ACGGCAGCGT TTTCAGACGGCATACGATGT CGCGGTCGAT TTCGACAACG 551 TGCAGGCGGT TCAGCTTTTT CGCCAAAGGTTCGGTAATTG CCGCCAAACC 601 CGGGCCGATT TCAATCACGA CATCATCCGC CTGCGGGCGCACGGCGTTGA 651 CAATATCGCC GATAATCCGC GTGTCCTGCA AAAAATTCTG CCCGAAACGC701 TTGCGGGCTT TGTGTTCTTT CATCGTGTTT CCTCTTCGGT TGAAACCCCG 751CCCTTTAGGG CGGCAGGATC AGACTCTGTT TGGGCGGGGC GTAACCCCTT 801 CCAAATCAGGACGACACATA GGGCGGTGCT TTATGTGTCG TCCTGTGTGT 851 TGGAACATAA ATGTGTTTACAGTATCCGTT TGATGTCGGC ATTGTAAThis corresponds to the amino acid sequence <SEQ ID 2658; ORF 772.ng>:

g772.pep 1 VFGTVLRTDA DCLQIIVVGK FFQVVAYGFA ALAEGEFHQF GEMIEIVRLA 51DTVFHRNHAH HCGIDFRRGI ERFGRHVNQQ LHIEKILQHH TQATVVVAFR 101 RGNHALDHFFLQHKVHIGDI VRHLRQFEQK RRGDVIRQVA DDFLFA*DAV 151 EIKLQHVAFV NHQFIRKRQRFQTAYDVAVD FDNVQAVQLF RQRFGNCRQT 201 RADFNHDIIR LRAHGVDNIA DNPRVLQKILPETLAGFVFF HRVSSSVETP 251 PFRAAGSDSV WAGRNPFQIR TTHRAVLYVS SCVLEHKCVYSIRLMSAL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2659>:

m772.seq 1 ATGTTCGGCG CGGTCTTGCG GATTGATGCC GACTGCCTGC AAATCATCGT 51CGCCTGCAAG CTCTTTCAGA TTGTTGCGTA TGGTTTTGCG GCGTTGGTGG 101 AAGGCGAGTTTCACGAGTTT GGCAAAATGC TCGAAATCGT CCGCCTTGCC 151 GATGCGGTGT TTCACCGGAATCATACGGAC GACGGCGGAA TCCACTTTCG 201 GCGCAGGGTC GAACGATTCG GGCGGTACGTCAATCAGCAT TTCCATATCG 251 AAAAAATATT GCAGCATCAC GCCCAAGCGG CCGTAGTCGTTGCTTTTCGG 301 CGCGGCAACC ATACGCTCGA CCACTTCTTT TTGCAGCATA AAGTGCATAT351 CGACGACATC GTCCGCCACC TCCGCCAGCT TGAACAAAAG CGGTGTGGAA 401ATGTTGTACG GGAGGTTGCC GACGATTTTC TTTTTGCCTG CGATGCCGTT 451 GAAATCAAACTGCAATACAT CGCCTTCGTG AATCACCAGT TTATCCGCAA 501 ACGGCAGCGT TTTCAGACGGCATACGATGT CGCGGTCGAT TTCGACAACG 551 TGCAGGCGGT TCAGCTTTTT CGCCAAAGGTTCGGTAATCG CCGCCAAACC 601 CGGGCCGATT TCAATCACGA CATCATCCGC CTGCGGGCGCACGGCGTTGA 651 CAATATCGCT GATAATCCGC GTGTCCTGCA AAAAATTCTG CCCGAAACGC701 TTGCGGGCTT TGTGTTCTTT CATCGTGTTT CCTTTTCGGT TGAAACCCCG 751CCCTTTAGGG CGGTAGAATC AGACTCTATT TGGGAGGGGC GTAACTCTTT 801 CCAAATCAGGATGGCACATA GGGCGGTGCT TTATGTGTCG TCCTGTGTGT 851 TGAAACATAA ATGTGTTTACAGTATCCGTT TGATGTCGGC ATTGTAAThis corresponds to the amino acid sequence <SEQ ID 2660; ORF 772>:

m772.pep 1 MFGAVLRIDA DCLQIIVACK LFQIVAYGFA ALVEGEFHEF GKMLEIVRLA 51DAVFHRNHTD DGGIHFRRRV ERFGRYVNQH FHIEKILQHH AQAAVVVAFR 101 RGNHTLDHFFLQHKVHIDDI VRHLRQLEQK RCGNVVREVA DDFLFACDAV 151 EIKLQYIAFV NHQFIRKRQRFQTAYDVAVD FDNVQAVQLF RQRFGNRRQT 201 RADFNHDIIR LRAHGVDNIA DNPRVLQKILPETLAGFVFF HRVSFSVETP 251 PFRAVESDSI WEGRNSFQIR MAHRAVLYVS SCVLKHKCVYSIRLMSAL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 772 shows 85.2% identity over a 298 aa overlap with a predicted ORF(ORF 772) from N. gonorrhoeae

m772/g772 85.2% identity in 298 aa overlap        10        20        30        40        50        60 g772.pepVFGTVLRLDADCLQIIVVGKFFQVVAYGFAALAEGEFHQFGEMIEIVRLADTVFHRNHAH:||:||| |||||||||: |:||:||||||||:|||||:||:|:|||||||:||||||: m772MFGAVLRIDADCLQIIVACKLFQIVAYGFAALVEGEFHEFGKMLEIVRLADAVFHRNHTD        10        20        30        40        50        60        70        80        90       100       110       120 g772.pepHCGIDFRRGIERFGRHVNQQLHIEKILQHHTQATVVVAFRRGNHALDHFFLQHKVHIGDI  || ||| :|||||:|||::|||||||||:||:||||||||||:|||||||||||| || m772DGGIHFRRRVERFGRYVNQHFHIEKILQHHAQAAVVVAFRRGNHTLDHFFLQHKVHIDDI        70        80        90       100       110       120       130       140       150       160       170       180 g772.pepVRHLRQFEQKRRGDVIRQVADDFLFAXDAVEIKLQHVAFVNHQFIRKRQRFQTAYDVAVD||||||:|||| |:|:|:|||||||| ||||||||:||||||||||||||||||||||| m772VRHLRQLEQKRCGNVVREVADDFLFACDAVEIKLQYIAFVNHQFIRKRQRFQTAYDVAVD       130       140       150       160       170       180       190       200       210       220       230       240 g772.pepFDNVQAVQLFRQRFGNCRQTRADFNHDIIRLRAHGVDNIADNPRVLQKILPETLAGFVFF|||||||||||||||| ||||||||||||||||||||||||||||||||||||||||||| m772FDNVQAVQLFRQRFGNRRQTRADFNHDIIRLRAHGVDNIADNPRVLQKILPETLAGFVFF       190       200       210       220       230       240       250       260       270       280       290      299 g772.pepHRVSSSVETPPFRAAGSDSVWAGRNPFQIRTTHRAVLYVSSCVLEHKCVYSIRLMSALX|||| |||||||||: |||:| ||| |||| :||||||||||||:|||||||||||||| m772HRVSFSVELPPFRAVESDSIWEGRNSFQIRMAHRAVLYVSSCVLKHKCVYSIRLMSALX       250       260       270       280       290The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2661>:

a772.seq 1 ATGTTCGGCG CGGTCTTGCG GATTGATGCC GACTGCCTGC AAATCATCGT 51CGCCTGCAAG CTCTTTCAGA TTGTTGCGTA TGGTTTTGCG GCGTTGGTGG 101 AAGGCGAGTTTCACGAGTTT GGCGAAATGC TCGAAATCGT CCGCCTTGCC 151 GATACGGTGT TTCACCGGAATCATGCGGAC GACGGCCGAA TCCACTTTCG 201 GCGCGGGGTC GAACGATTCG GGCGGCACGTCAATCAGCAT TTCCATATCG 251 AAGAAATATT GCAGCATCAC GCCCAAGCGG CCGTAGTCGTTGCTTTTCGG 301 CGCGGCAACC ATACGATCGA CCACTTCTTT TTGCAGCATA AAGTGCATAT351 CGACGACATC GTCCGCCACC TCCGCCAGCT TGAACAAAAG CGGCGTGGAA 401ATGTTGTAGG GCAGGTTGCC GACGATTTTC TTTTTGCCTG CGATGCCGTT 451 GAAATCAAACTGCAATACAT CGCCTTCGTG AATCACCAGT TTATCCGCAA 501 ACGGCAGCGT TTTCAGACGGCATACGATGT CGCGGTCGAT TTCGACAACG 551 TGCAGGCGGT TCAGCTTTTT CGCCAAAGGTTCGGTAATCG CCGCCAAACC 601 CGGACCGATT TCAATCACGA CATCATCCGC CTGCGGGCGCACGGCGTTGA 651 CAATATCGCT GATAATCCGC GTGTCCTGCA AAAAATTCTG CCCGAAACGC701 TTGCGGGCTT TGTGTTCTTT CATCGTGTTT CCTTTTCGGT TGAAACCCCG 751CCCTTTAGGG CGGTAGAATC AGACTCTATT TGGGAGGGGC GTAACTCCTT 801 CCAAATCAGGACGGCACATA GGGCGGTGCT TTATGTGTCG TCCTGTGTGT 851 TGAAACATAA ATGTGTTTACAGTATCCGTT TGATGTCGGC ATTGTAAThis corresponds to the amino acid sequence <SEQ ID 2662; ORF 772.a>:

a772.pep 1 MFGAVLRIDA DCLQIIVACK LFQIVAYGFA ALVEGEFHEF GEMLEIVRLA 51DTVFHRNHAD DGRIHFRRGV ERFGRHVNQH FHIEEILQHH AQAAVVVAFR 101 RGNHTIDHFFLQHKVHIDDI VRHLRQLEQK RRGNVVGQVA DDFLFACDAV 151 EIKLQYIAFV NHQFIRKRQRFQTAYDVAVD FDNVQAVQLF RQRFGNRRQT 201 RTDFNHDIIR LRAHGVDNIA DNPRVLQKILPETLAGFVFF HRVSFSVETP 251 PFRAVESDSI WEGRNSFQIR TAHRAVLYVS SCVLKHKCVYSIRLMSAL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 772 shows 95.6% identity over a 298 aa overlap with a predicted ORF(ORF 772) from N. meningitidis

m772/a772 95.6% identity in 298 aa overlap        10        20        30        40        50        60 a772.pepMFGAVLRIDADCLQIIVACKLFQIVAYGFAALVEGEFHEFGEMLEIVRLADTVFHRNHAD|||||||||||||||||||||||||||||||||||||||||:|||||||||:||||||:| m772MFGAVLRIDADCLQIIVACKLFQIVAYGFAALVEGEFHEFGKMLEIVRLADAVFHRNHTD        10        20        30        40        50        60        70        80        90       100       110       120 a772.pepDGRIHFRRGVERFGRHVNQHFHIEEILQHHAQAAVVVAFRRGNHTIDHFFLQHKVHIDDI|| ||||| ||||||:||||||||:||||||||||||||||||||:|||||||||||||| m772DGGIHFRRRVERFGRYVNQHFHIEKILQHHAQAAVVVAFRRGNHTLDHFFLQHKVHIDDI        70        80        90       100       110       120       130       140       150       160       170       180 a772.pepVRHLRQLEQKRRGNVVGQVADDFLFACDAVEIKLQYIAFVNHQFIRKRQRFQTAYDVAVD||||||||||| |||| :|||||||||||||||||||||||||||||||||||||||||| m772VRHLRQLEQKRCGNVVREVADDFLFACDAVEIKLQYIAFVNHQFIRKRQRFQTAYDVAVD       130       140       150       160       170       180       190       200       210       220       230       240 a772.pepFDNVQAVQLFRQRFGNRRQTRLDFNHDIIRLRAHGVDNIADNPRVLQKILPETLAGFVFF|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| m772FDNVQAVQLFRQRFGNRRQTRADFNHDIIRLRAHGVDNIADNPRVLQKILPETLAGFVFF       190       200       210       220       230       240       250       260       270       280       290      299 a772.pepHRVSFSVELPPFRAVESDSIWEGRNSFQIRTAHRAVLYVSSCVLKHKCVYSIRLMSALX|||||||||||||||||||||||||||||| |||||||||||||||||||||||||||| m772HRVSFSVELPPFRAVESDSIWEGRNSFQIRMAHRAVLYVSSCVLKHKCVYSIRLMSALX       250       260       270       280       290

g773.seq not found yet

g773.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2663>:

m773.seq 1 ATGGGATTGG GTGCAACGAC TTTTGTCGGT TCGGGTGCTA TAGGCGGAGG 51TCTGTGCAGT ACCGGGATTG GCTGTGCGGC CGGTGGACTT ATTGCAACGG 101 CAGGTATGACCGGTGGTTAT ACACAGGCCT CAGAAGGAAG CCGGCAATTG 151 TTTGGCACTT ACCAGTCCGATTTTGGTAAA AAAGTTGTCC TATCTTTGGG 201 TACACCAATA GAATACGAAT CGCCGTTAGTATCTGATGCG AAAAATCTAG 251 CCGTATGGGG ATTGGAAACG CTGATTACGC GCAAATTGGGAAACTTGGCA 301 ACGGGTGTGA AAACTTCCTT GACTCCGAAA ACTGCTGACG TACAGCGAAA351 TATCCTGTCC CAATCCGAAG TCGGTATCAA GTGGGGCAAG GGGATTGAAG 401GACAGGGAAT GCCTTGGGAG GATTATGTCG GTAAGGGCTT GTCTGCCAAT 451 GCAAGGTTACCTAAAAATTT TAAAACATTT GATTATTTTG ATCGTGGTAC 501 AGGCACGGCA ATCAGTGCCAAAACTCTGGA TACGCAAACT ACGGCACGCC 551 TGTCCAAACC CGAACAGCTT TACAGTACCATGAAAGGGTA CATCGATAAG 601 ACGGCAAATT TCAAAAGTTA TGAATTATCA GAAGTACCGTTAAGGGCAGA 651 CATGATCAAA CAGCGCGAAA TCCATCTGGC CATACCCGCA CAAACTAATA701 AGGAGCAAAG ATTGCAGTTG CAACGTGTGG TAGAGTATGG CAAAAGTCAA 751AACATTACAG TCAAAATTAC GGAGATCGAA TAAThis corresponds to the amino acid sequence <SEQ ID 2664; ORF 773>:

m773.pep 1 MGLGATTFVG SGAIGGGLCS TGIGCAAGGL IATAGMTGGY TQASEGSRQL 51FGTYQSDFGK KVVLSLGTPI EYESPLVSDA KNLAVWGLET LITRKLGNLA 101 TGVKTSLTPKTADVQRNILS QSEVGIKWGK GIEGQGMPWE DYVGKGLSAN 151 ARLPKNFKTF DYFDRGTGTAISAKTLDTQT TARLSKPEQL YSTMKGYIDK 201 TANFKSYELS EVPLRADMIK QREIHLAIPAQTNKEQRLQL QRVVEYGKSQ 251 NITVKITEIE *

a773.seq not found yet

a773.pep not found yet

The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2665>:

g774.seq 1 ATGAAGACCA AATTACCGCT TTTTATCATT TGGCTGTCTG TGTCTGCCTC 51CTGTGCTTCC GTTTTACCCG TTCCGGAGGG CAGCCGAACC GAAATGCCGA 101 CACAGGAAAATGCTTCAGAC GGCATTCCCT ATCCCGTTCC CACTCTGCAA 151 GACCGTTTGG ACTATCTGGAAGGCAAAATC GTCCGGCTGT CGAACGAAGT 201 GGAAATGTTA AACGGGAAAG TCAAAGCATTGGAGCATACG AAAATACACC 251 CTTCCGGCAG GACATACGTC CAAAAACTCG ACGACCGCAAATTGAAAGAG 301 CATTACCTCA ATACCGAAGG CGGCAGCGCA TCCGCACATA CCGTCGAAAC351 CGCACAAAAC CTCTACAATC AGGCACTCAA ACACTATCAA AACGGCAGGT 401TTTCTGCCGC AGCCGCCTTG TTGAAGGGGG CGGACGGCGG AGACGGCGGC 451 AGCATCGCGCAACGCAGTAT GTACCTGTTG CTGCAAAGCA GGGCGCGTAT 501 GGGGAACTGT GAATCTGTCATCGAAATCGG AGGGCGTTAC GCCAACCGTT 551 TCAAAGACAG CCCAACCGCG CCCGAAGTCATATTCAAAAT CGGCGAATGC 601 CAATACAGGC TTCAGCAAAA AGACATTGCA AGGGCGACTTGGCGCAGCCT 651 GATACAGACC TATCCCGGCA GCCCGGCGGC AAAACGCGCC GCCGCAGCCG701 TACGCAAACG ATAGThis corresponds to the amino acid sequence <SEQ ID 2666; ORF 774.ng>:

g774.pep 1 MKTKLPLFII WLSVSASCAS VLPVPEGSRT EMPTQENASD GIPYPVPTLQ 51DRLDYLEGKI VRLSNEVEML NGKVKALEHT KIHPSGRTYV QKLDDRKLKE 101 HYLNTEGGSASAHTVETAQN LYNQALKHYQ NGRFSAAAAL LKGADGGDGG 151 SIAQRSMYLL LQSRARMGNCESVIEIGGRY ANRFKDSPTA PEVIFKIGEC 201 QYRLQQKDIA RATWRSLIQT YPGSPAAKRAAAAVRKR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2667>:

m774.seq 1 ATGAAGATCA AATTACCGCT TTTTATCATT TGGCTGTCTG TGTCCGCCTC 51CTGTGCTTCC GTTTCACCCG TTCCGGCAGG CAGCCAAACC GAAATGTCGA 101 CACGGGAAAATGCTTCAGAC GGCATTCCCT ATCCCGTTCC GACCTTGCAA 151 GACCGTTTGG ACTATCTGGAAGGCAAAATC GTCCGGCTGT CGAACGAAGT 201 GGAAACCTTA AACGGCAAAG TCAAAGCACTGGAACACGCA AAAACACATT 251 CTTCCGGCAG GGCATACGTC CAAAAACTCG ACGACCGCAAGTTGAAAGAG 301 CATTACCTCA ATACCGAAGG CGGCAGCGCA TCCGCACATA CTGTCGAAAC351 CGCACAAAAC CTCTACAATC AGGCACTCAA ACACTATAAA AGCGGCAAGT 401TTTCTGCCGC TGCCTCCCTG TTGAAAGGCG CGGACGGAGG CGACGGCGGC 451 AGCATCGCGCAACGCAGTAT GTACCTGTTG CTGCAAAGCA GGGCGCGTAT 501 GGGCAACTGC GAATCCGTCATCGAAATCGG AGGGCGTTAC GCCAACCGTT 551 TCAAAGACAG CCCAACCGCG CCTGAAGCCATGTTCAAAAT CGGCGAATGC 601 CAATACAGGC TTCAGCAAAA AGACATTGCA AGGGCGACTTGGCGCAGCCT 651 GATACAGACC TATCCCGGCA GCCCGGCGGC AAAACGCGCC GCCGCAGCCG701 TGCGCAAACG ATAGThis corresponds to the amino acid sequence <SEQ ID 2668; ORF 774>:

m774.pep 1 MKIKLPLFII WLSVSASCAS VSPVPAGSQT EMSTRENASD GIPYPVPTLQ 51DRLDYLEGKI VRLSNEVETL NGKVKALEHA KTHSSGRAYV QKLDDRKLKE 101 HYLNTEGGSASAHTVETAQN LYNQALKHYK SGKFSAAASL LKGADGGDGG 151 SIAQRSMYLL LQSRARMGNCESVIEIGGRY ANRFKDSPTA PEAMFKIGEC 201 QYRLQQKDIA RATWRSLIQT YPGSPAAKRAAAAVRKR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 774 shows 92.8% identity over a 237 aa overlap with a predicted ORF(ORF 774) from N. gonorrhoeae

m774/g774 92.8% identity in 237 aa overlap        10        20        30        40        50        60 g774.pepMKTKLPLFIIWLSVSASCASVLPVPEGSRTEMPTQENASDGIPYPVPTLQDRLDYLEGKI|| |||||||||||||||||| ||| ||:||| |:||||||||||||||||||||||||| m774MKIKLPLFIIWLSVSASCASVSPVPAGSQTEMSTRENASDGIPYPVPTLQDRLDYLEGKI        10        20        30        40        50        60        70        80        90       100       110       120 g774.pepVRLSNEVEMLNGKVKALEHTKIHPSGRTYVQKLDDRKLKEHYLNTEGGSASAHTVETAQN|||||||| ||||||||||:| | |||:|||||||||||||||||||||||||||||||| m774VRLSNEVETLNGKVKALEHAKTHSSGRAYVQKLDDRKLKEHYLNTEGGSASAHTVETAQN        70        80        90       100       110       120       130       140       150       160       170       180 g774.pepLYNQALKHYQNGRFSAAAALLKGADGGDGGSIAQRSMYLLLQSRARMGNCESVIEIGGRY|||||||||::|:|||||:||||||||||||||||||||||||||||||||||||||||| m774LYNQALKHYKSGKFSAAASLLKGADGGDGGSIAQRSMYLLLQSRARMGNCESVIEIGGRY       130       140       150       160       170       180       190       200       210       220       230 g774.pepANRFKDSPLAPEVIFKIGECQYRLQQKDIARATWRSLIQTYPGSPAAKRAAAAVRKRX||||||||||||::|||||||||||||||||||||||||||||||||||||||||||| m774ANRFKDSPLAPEAMFKIGECQYRLQQKDIARATWRSLIQTYPGSPAAKRAAAAVRKRX       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2669>:

a774.seq 1 ATGAAGACCA AATTACCGCT TTTTATCATT TGGCTGTCCG TATCCGCCGC 51CTGTTCTTCC CCTGTTTCCC GCAATATTCA GGATATGCGG CTCGAACCGC 101 AGGCAGAGGCAGGTAGTTCG GACGCTATTC CCTATCCCGT TCCCACTCTG 151 CAAGACCGTT TGGATTATCTGGAAGGCACA CTCGTCCGCC TGTCGAACGA 201 AGTGGAAACC TTAAACGGCA AAGTCAAAGCACTGGAGCAT GCGAAAACAC 251 ACCCTTCCAG CAGGGCATAC GTCCAAAAAC TCGACGACCGCAAGTTGAAA 301 GAGCATTACC TCAATACCGA AGGCGGCAGC GCATCCGCAC ATACCGTCGA351 AACCGCACAA AACCTCTACA ATCAGGCACT CAAACACTAT AAAAGCGGCA 401GGTTTTCTGC CGCTGCCTCC CTGTTGAAAG GCGCGGACGG AGGCGACGGC 451 GGCAGCATCGCGCAACGCAG TATGTACCTG TTGCTGCAAA GCAGGGCGCG 501 TATGGGCAAC TGCGAATCCGTCATCGAAAT CGGAGGGCGT TACGCCAACC 551 GTTTCAAAGA CAGCCCAACC GCGCCTGAAGCCATGTTCAA AATCGGCGAA 601 TGCCAATACA GGCTTCAGCA AAAAGACATT GCAAGGGCGACTTGGCGCAG 651 CCTGATACAG ACCTATCCCG GCAGCCCGGC GGCAAAACGC GCCGCCGCAG701 CCGTGCGCAA ACGATAGThis corresponds to the amino acid sequence <SEQ ID 2670; ORF 774.a>:

a774.pep 1 MKTKLPLFII WLSVSAACSS PVSRNIQDMR LEPQAEAGSS DAIPYPVPTL 51QDRLDYLEGT LVRLSNEVET LNGKVKALEH AKTHPSSRAY VQKLDDRKLK 101 EHYLNTEGGSASAHTVETAQ NLYNQALKHY KSGRFSAAAS LLKGADGGDG 151 GSIAQRSMYL LLQSRARMGNCESVIEIGGR YANRFKDSPT APEAMFKIGE 201 CQYRLQQKDI ARATWRSLIQ TYPGSPAAKRAAAAVRKR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 774 shows 89.5% identity over a 238 aa overlap with a predicted ORF(ORF 774) from N. meningitidis

m774/a774 89.5% identity in 238 aa overlap          10        20        30        40        50        60 a774.pep  MKTKLPLFIIWLSVSAACSSPVSRNIQDMRLEPQAEAGSSDAIPYPVPTLQDRLDYLEGT  || |||||||||||||:|:| ||      : | ::: ::||:||||||||||||||||| m774  MKIKLPLFIIWLSVSASCAS-VSPVPAGSQTEMSTRENASDGIPYPVPTLQDRLDYLEGK          10        20         30        40        50          70        80        90       100       110       120 a774.pep  LVRLSNEVETLNGKVKALEHAKTHPSSRAYVQKLDDRKLKEHYLNTEGGSASAHTVETAQ  :||||||||||||||||||||||| |:||||||||||||||||||||||||||||||||| m774  IVRLSNEVETLNGKVKALEHAKTHSSGRAYVQKLDDRKLKEHYLNTEGGS ASAHTVETAQ 60        70        80        90       100       110         130       140       150       160       170       180 a774.pep  NLYNQALKHYKSGRFSAAASLLKGADGGDGGSIAQRSMYLLLQSRARMGNCESVIEIGGR  |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||| m774  NLYNQALKHYKSGKFSAAASLLKGADGGDGGSIAQRSMYLLLQSRARMGNCESVIEIGGR120       130       140       150       160       170         190       200       210       220       230      239 a774.pep  YANRFKDSPLAPEAMFKIGECQYRLQQKDIARATWRSLIQTYPGSPAAKRAAAAVRKRX  ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m774  YANRFKDSPLAPEAMFKIGECQYRLQQKDIARATWRSLIQTYPGSPAAKRAAAAVRKRX180       190       200       210       220       230

g790.seq not found yet

g790.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2671>:

m790.seq 1 ATGGCAAGAA GGTCAAAAAC ATTTGAAGAA GCTGCTGCTG AGGTTGAGGA 51ACGTTTCGGT CATCGTGGCA TTAAGTTGGT CGAGTTTGAG GGTACAGCCA 101 AGCCGTGTGTAATCAACTGC CCTAAACATG GAAACCAAAC CTGTTCGAGG 151 TACTCCAATA TGTTCATAGGAAGTAGCTGG GGTTGCCCCT CTTGTGGTAA 201 TGAGCAAGCT GCAAAAGCCG GTATAGCGACCCTTAGGAAG AATCACATAG 251 CGTTAGAAAT GCTGAAACAG GCTGTAACAG GTATGACCAAGCAAGAGCGC 301 ATCACGACGC AAGCCTACAA TGAGATGACC AAATCCGTGG CAGGTTCAAA351 CAGCATAGTC CTTAACGATG TCCAAGGCGA TACGACCATC AACAACCATC 401ATACGCATAC GCACAACCAC AGCGATGCCG ATGGCAAAGC ACTGTCGATG 451 AGGCTCACACCCCGTCCTTT GTTGTCAGAC CGTCAGGCGG CGGCTTTCGC 501 CCGTACAGGC AAACTCACGGGCAGTTTCGA CCTGTTTGCT TCGGTGgTCG 551 CCCCCTCGCA GTACACGTTT GCCGTTGCCATGCCCGACAC GTCCATGTCG 601 CCGGTTATCG AAAAGGGAGA CTTGCTGGTG GTCGAGCCGCGTATGTGCCC 651 TGCGGACGAA GACATCGCGC TGATTGAACT GTCCGACAAG CGGCTGGTCG701 TCGCGCACCT TGTTATCGAT ATTGCGGGCA GGATGCTGAT TTATCAGACG 751GGCAGGCCGT CTGAAGCCTT TGACCTGCCC GAAGGCAGCA CGATTTTAGG 801 TGTGGTGCTGGAGTCAAAAA ACGGTTTATG TCCGCCGCAC AGGCAAGAAG 851 GCGTGTTGAT TCGGATTACCGCCCCTGATG TGTGGACGGT TGGTATGATT 901 TCCGCTTCCA AAACGTCGTG TACGCGCCCGACCGCAGCCC GGAAATCAGC 951 CGTATGCTTT CTTCGATTTT GGCAGGCTAC GCGTGGGATACCGAAAACCC 1001 GTTCGTGGCG AAATCCGAAC AACGCCTGAThis corresponds to the amino acid sequence <SEQ ID 2672; ORF 790>:

m790.pep 1 MARRSKTFEE AAAEVEERFG HRGIKLVEFE GTAKPCVINC PKHGNQTCSR 51YSNMFIGSSW GCPSCGNEQA AKAGIATLRK NHIALEMLKQ AVTGMTKQER 101 ITTQAYNEMTKSVAGSNSIV LNDVQGDTTI NNHHTHTHNH SDADGKALSM 151 RLTPRPLLSD RQAAAFARTGKLTGSFDLFA SVVAPSQYTF AVAMPDTSMS 201 PVIEKGDLLV VEPRMCPADE DIALIELSDKRLVVAHLVID IAGRMLIYQT 251 GRPSEAFDLP EGSTILGVVL ESKNGLCPPH RQEGVLIRITAPDVWTVGMI 301 SASKTSCTRP TAARKSAVCF LRFWQATRGI PKTRSWRNPN NA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2673>:

a790.seq 1 ATGGCAAGAA GGTCAAAAAC ATTTGAAGAA GCTGCTGCTG AGGTTGAGGA 51ACGTTTCGGT CATCGTGGCA TTAAGTTGGT CGAGTTTGAG GGTACAGCCA 101 AGCCGTGTGTAATCAACTGC CCTAAACATG GAAACCAAAC CTGTTCGAGG 151 TACTCCAATA TGTTCATAGGAAGTAGCTGG GGTTGCCCCT CTTGTGGTAA 201 TGAGCAAGCT GCAAAAGCCG GTATAGCGACCCTTAGGAAG AATCACATAG 251 CGTTAGAAAT GCTGAAACAG GCTGTAACAG GTATGACCAAGCAAGAGCGC 301 ATCACGACGC AAGCCTACAA TGAGATGACC AAATCCGTGG CAGGTTCAAA351 CAGCATAATC CTTAACGATG TCCAAGGCGA TACGACCATC AACAACCATC 401ATACGCATAC GCACAACCAC AGCGATGCCG ACGGCAAAGC ACTGTCGATG 451 AGGCTCACACCCCGTCCTTT GTTGTCAGAC CGTCAGGCGG CGGCTTTCGC 501 CCGTACAGGC AAACTCACGGGCAGTTTCGA CCTGTTTGCT TCGGTGGTCG 551 CCCCTTCACA ATATACGTTT GCCGTTGCCATGCCCGACAC GTCCATGTCG 601 CCGGTTATCG AAAAGGGGGA TTTGCTGGTG GTCGAGCCGCGTATGCGCCC 651 TGCGGACGAA GACATCGTAC TGATTGAACT GTCCGACAAG CGGCTGGTCG701 TCGCGCACCT TGTTATCGAT ATTGCGGGCA GGATGCTGAT TTATCAGACG 751GGCAGGCCGT CTGAAGCCCT CGACCTGCCC GAAGGCAGCG TGATTTTAGG 801 TGTGGTGCTGGAGTCAAAAA ACGGTTTATG TCCGCCGCAC AGGCAAGAAG 851 GCGTGTTGAT TCGGATTACCGCCCCTGATG TGTGGACGGT TGGTACGATT 901 TCCGCTTCCA AAACGTCGTG TACGCGCCCGACCGCAGCCC GGAAATCAGC 951 CGTATGCTTT CTTCGATTTT GGCAGGCTAC GCGTGGGATACCGAAAACCC 1001 GTTCGTGGCG AAATCCGAAC AACGCCTGTThis corresponds to the amino acid sequence <SEQ ID 2674; ORF 790.a>:

a790.pep 1 MARRSKTFEE AAAEVEERFG HRGIKLVEFE GTAKPCVINC PKHGNQTCSR 51YSNMFIGSSW GCPSCGNEQA AKAGIATLRK NHIALEMLKQ AVTGMTKQER 101 ITTQAYNEMTKSVAGSNSII LNDVQGDTTI NNHHTHTHNH SDADGKALSM 151 RLTPRPLLSD RQAAAFARTGKLTGSFDLFA SVVAPSQYTF AVAMPDTSMS 201 PVIEKGDLLV VEPRMRPADE DIVLIELSDKRLVVAHLVID IAGRMLIYQT 251 GRPSEALDLP EGSVILGVVL ESKNGLCPPH RQEGVLIRITAPDVWTVGTI 301 SASKTSCTRP TAARKSAVCF LRFWQATRGI PKTRSWRNPN NACComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 790 shows 98.2% identity over a 342 aa overlap with a predicted ORF(ORF 790) from N. meningitidis

a790/m790 98.2% identity in 342 aa overlap        10        20        30        40        50        60 a790.pepMARRSKTFEEAAAEVEERFGHRGIKLVEFEGTAKPCVINCPKHGNQTCSRYSNMFIGSSW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m790MARRSKTFEEAAAEVEERFGHRGIKLVEFEGTAKPCVINCPKHGNQTCSRYSNMFIGSSW        10        20        30        40        50        60        70        80        90       100       110       120 a790.pepGCPSCGNEQAAKAGIATLRKNHIALEMLKQAVTGMTKQERITTQAYNEMTKSVAGSNSII|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: m790GCPSCGNEQAAKAGIATLRKNHIALEMLKQAVTGMTKQERITTQAYNEMTKSVAGSNSIV        70        80        90       100       110       120       130       140       150       160       170       180 a790.pepLNDVQGDTTINNHHTHTHNHSDADGKALSMRLTPRPLLSDRQAAAFARTGKLTGSFDLFA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m790LNDVQGDTTINNHHTHTHNHSDADGKALSMRLTPRPLLSDRQAAAFARTGKLTGSFDLFA       130       140       150       160       170       180       190       200       210       220       230       240 a790.pepSVVAPSQYTFAVAMPDTSMSPVIEKGDLLVVEPRMRPADEDIVLIELSDKRLVVAHLVID||||||||||||||||||||||||||||||||||| ||||||:||||||||||||||||| m790SVVAPSQYTFAVAMPDTSMSPVIEKGDLLVVEPRMCPADEDIALIELSDKRLVVAHLVID       190       200       210       220       230       240       250       260       270       280       290       300 a790.pepIAGRMLIYQTGRPSEALDLPEGSVILGVVLESKNGLCPPHRQEGVLIRITAPDVWTVGTI||||||||||||||||:||||||:|||||||||||||||||||||||||||||||||| | m790IAGRMLIYQTGRPSEAFDLPEGSTILGVVLESKNGLCPPHRQEGVLIRITAPDVWTVGMI       250       260       270       280       290       300       310       320       330       340 a790.pepSASKTSCTRPTAARKSAVCFLRFWQATRGIPKTRSWRNPNNAC|||||||||||||||||||||||||||||||||||||||||| m790SASKTSCTRPTAARKSAVCFLRFWQATRGIPKTRSWRNPNNAX       310       320       330       340The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2675>:

g791.seq 1 ATGGTAAATT ATTATTCAGC TATGATTAAA AAGATTTTAA CTACTTGTTT 51TGGTTTGTTT TTTGGTTTTT GTGTATTTGG AGTGGGTCTG GTTGCCATTG 101 CTATTTTGGTAACGTATCCG AAACTGCCGT CTTTGGATTC TTTGCAGCAT 151 TACCAGCCTA AAATGCCGTTGACTATTTAT TCGGCGGATG GAGAAGTCAT 201 CGGTATGTAT GGGGAGCAGC GGCGCGAATTTACAAAAATC GGCGATTTCC 251 CCGAGGTGTT GCGGAATGCG GTTATTGCCG CCGAGGATAAACGCTTTTAC 301 CGGCATTGGG GGGTGGATGT TTGGGGTGTT GCCCGCGCTG CCGTCGGCAA351 TGTCGTGTCC GGCAGCGTGC AGTCGGGTGC GAGTACGATT ACACAGCAGG 401TGGCGAAAAA TTTTTATTTG AGCAGTGAAA AAACGTTCAC ACGCAAATTC 451 AATGAGGTGTTGCTTGCCTA TAAAATCGAG CAGTCTTTAA GCAAAGACAA 501 AATCCTTGAG TTGTATTTCAATCAGATTTA CCTCGGTCAG CGCGCCTATG 551 GTTTTGCATC TGCCGCGCAA ATCTATTTCAATAAGAATGT CCGAGATTTG 601 ACTTTGGCGG AAGCCGCCAT GCTTGCGGGA CTGCCCAAGGCTCCGTCTGC 651 CTATAATCCG ATTGTTAATC CGGAGCGTGC CAAGTTGCGC CAGAAGTATA701 TTTTGAACAA TATGCTCGAG GAGAAGATGA TTACCGTGCA ACAGCGCGAT 751CAGGCATTGA ATGAGGAACT GCATTATGAG CGGTTTGTTC GGAAAATCGA 801 TCAGAGTGCTTTATATGTGG CGGAAATGGT GCGTCGGGAA CTGTATGAGA 851 AATATGGTGA AGATGCCTATACGCAGGGTT TTAAGGTTTA TACCACGGTC 901 CGCACCGATC ATCAGAAGGC GGCAACCGAGGCATTGCGCA AGGCTCTACG 951 GAATTTCGAT CGCGGCAGCA GCTACCGCGG TGCGGAAAACTATATCGATT 1001 TGAGTAAGAG TGAAGATGTC GAGGAGACTG TCAGCCAGTA TCTGTCGGGA1051 CTCTATACCG TCGATAAAAT GGTTCCCGCC GTTGTGTTGG ATGTTACTAA 1101AAAGAAAAAT GTCGTCATAC AGCTGCCCGG CGGCAGGCGG GTTGCGCTTG 1151 ACAGGCGCGCCTTGGGTTTT GCGGCCCGAG CGGTCGATAA TGAGAAAATG 1201 GGGGAGGACC GTATCCGCAGGGGCGCGGTC ATCCGTGTCA AAAACAACGG 1251 CGGGCGTTGG GCGGTGGTTC AAGAGCCGTTGCTGCAGGGG GCTTTGGTTT 1301 CGCTGGATGC AAAAACCGGA GCTGTGCGCG CGCTGGTCGGCGGTTATGAT 1351 TTTCACAGCA AAACATTCAA TCGTGCCGTT CAGGCAATGC GGCAGCCGGG1401 TTCGACCTTT AAGCCGTTTG TCTATTCGGC GGCATTATCT AAGGGGATGA 1451CCGCGTCCAC AGTGGTTAAC GATGCGCCGA TTTCCCTGCC GGGGAAAGGG 1501 CCGAACGGTTCGGTTTGGAC ACCTAAAAAT TCAGACGGCA GATATTCCGG 1551 CTACATTACT TTGAGACAGGCTCTGACGGC TTCCAAGAAT ATGGTTTCCA 1601 TCCGTATTTT GATGTCTATC GGTGTCGGTTACGCGCAACA GTATATCCGG 1651 CGTTTCGGCT TCAGGCCGTC CGAGCTGCCG GCAAGCCTGTCTATGGCTTT 1701 AGGTACGGGC GAGACGACGC CGTTGAAAGT GGCGGAGGCA TATAGTGTAT1751 TTGCGAACGG CGGATATAGG GTTTCTTCGC ACGTGATCGA TAAGATTTAT 1801GACAGAGACG GCAGGTTGCG CGCCCAAATG CAACCTTTGG TGGCAGGGCA 1851 AAATGCGCCTCAGGCAATCG ATCCGCGCAA TGCCTATATT ATGTATAAGA 1901 TTATGCAGGA TGTGGTCCGTGTCGGTACGG CAAGGGGGGC AGCTGCGTTG 1951 GGAAGAACGG ATATTGCCGG TAAAACGGGTACGACCAACG ACAATAAAGA 2001 TGCGTGGTTT GTCGGTTTTA ACCCTGATGT GGTTACTGCCGTATATATCG 2051 GCTTCGACAA ACCTAAGAGT ATGGGGCGTG CCGGCTACGG CGGTACGATT2101 GCGGTGCCGG TTTGGGTGGA CTATATGCGT TTTGCGTTGA AAGGAAAGCA 2151GGGCAAAGGG ATGAAAATGC CTGAAGGTGT GGTCAGCAGC AATGGCGAAT 2201 ACTATATGAAGGAACGTATG GTAACCGATC CGGGCTTGAT GCTGGACAAC 2251 AGCGGTATTG CGCCGCAACCTTCCCGACGG GCAAAAGAAG ATGATGAAGC 2301 GGCAGTAGAA AACGAACAGC AGGGAAGGTCTGACGAAACG CGTCAGGACG 2351 TACAGGAAAC GCCGGTGCTT CCGAGCAATA CGGATTCCAAACAGCAGCAG 2401 TTGGATTCCC TGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 2676; ORF 791.ng>:

g791.pep 1 MVNYYSAMIK KILTTCFGLF FGFCVFGVGL VAIAILVTYP KLPSLDSLQH 51YQPKMPLTIY SADGEVIGMY GEQRREFTKI GDFPEVLRNA VIAAEDKRFY 101 RHWGVDVWGVARAAVGNVVS GSVQSGASTI TQQVAKNFYL SSEKTFTRKF 151 NEVLLAYKIE QSLSKDKILELYFNQIYLGQ RAYGFASAAQ IYFNKNVRDL 201 TLAEAAMLAG LPKAPSAYNP IVNPERAKLRQKYILNNMLE EKMITVQQRD 251 QALNEELHYE RFVRKIDQSA LYVAEMVRRE LYEKYGEDAYTQGFKVYTTV 301 RTDHQKAATE ALRKALRNFD RGSSYRGAEN YIDLSKSEDV EETVSQYLSG351 LYTVDKMVPA VVLDVTKKKN VVIQLPGGRR VALDRRALGF AARAVDNEKM 401GEDRIRRGAV IRVKNNGGRW AVVQEPLLQG ALVSLDAKTG AVRALVGGYD 451 FHSKTFNRAVQAMRQPGSTF KPFVYSAALS KGMTASTVVN DAPISLPGKG 501 PNGSVWTPKN SDGRYSGYITLRQALTASKN MVSIRILMSI GVGYAQQYIR 551 RFGFRPSELP ASLSMALGTG ETTPLKVAEAYSVFANGGYR VSSHVIDKIY 601 DRDGRLRAQM QPLVAGQNAP QAIDPRNAYI MYKIMQDVVRVGTARGAAAL 651 GRTDIAGKTG TTNDNKDAWF VGFNPDVVTA VYIGFDKPKS MGRAGYGGTI701 AVPVWVDYMR FALKGKQGKG MKMPEGVVSS NGEYYMKERM VTDPGLMLDN 751SGIAPQPSRR AKEDDEAAVE NEQQGRSDET RQDVQETPVL PSNTDSKQQQ 801 LDSLF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2677>:

m791.seq 1 ATGGTAAATT ATTATTCAGC TATGATTAAA AAGATTTTAA CGACTTGTTT 51TGGTTTGGTT TTTGGGTTTT GTGTATTTGG AGTGGGTTTG GTTGCCATTG 101 CTATTTTGGTAACGTATCCG AAACTGCCGT CTTTGGATTC TTTGCAGCAT 151 TACCAGCCTA AAATGCCGTTGACTATTTAT TCGGCGGATG GGGAAGTCAT 201 CGGTATGTAT GGGGAGCAGC GGCGCGAATTTACAAAAATC GGCGATTTCC 251 CAGAGGTGTT GCGGAATGCG GTTATCGCCG CCGAGGATAAACGCTTTTAC 301 CGGCATTGGG GGGTGGATGT TTGGGGTGTT GCCCGCGCTG CCGTCGGCAA351 TGTCGTGTCC GGCAGCGTGC AGTCGGGTGC GAGTACGATT ACGCAGCAGG 401TGGCGAAAAA TTTTTATTTG AGCAGTGAAA AAACGTTCAC ACGCAAATTC 451 AATGAGGTGTTGCTTGCCTA TAAAATCGAG CAGTCTTTAA GCAAAGACAA 501 AATCCTCGAG TTGTATTTCAATCAGATTTA CCTCGGTCAG CGCGCCTATG 551 GTTTTGCATC TGCCGCGCAA ATCTATTTCAATAAGAATGT CCGAGATTTG 601 ACTTTGGCGG AAGCCGCCAT GCTTGCGGGA CTGCCCAAGGCTCCGTCTGC 651 CTATAATCCG ATTGTTAATC CAGAACGTGC CAAGTTGCGC CAGAAGTATA701 TTTTGAACAA TATGCTCGAG GAGAAGATGA TTACCGTGCA ACAGCGCGAT 751CAGGCGTTGA ATGAGGAACT GCATTACGAG CGGTTTGTTC GGAAAATCGA 801 TCAGAGTGCGTTATATGTGG CGGAAATGGT GCGTCAGGAA CTGTATGAGA 851 AATACGGTGA AGATGCCTATACGCAGGGTT TTAAGGTTTA TACCACGGTC 901 CGCGCCGATC ATCAGAAGGT GGCAACCGAGGCATTGCGCA AGGCTCTACG 951 GAATTTCGAT CGCGGCAGCA GCTACCGCGG TGCGGAAAACTATATCGATT 1001 TGAGTAAGAG TGAAGATGTC GAGGAGACTG TCAGCCAGTA TCTGTCGGGA1051 CTCTATACCG TCGATAAAAT GGTTCCCGCC GTTGTGTTGG ATGTGACTAA 1101AAAGAAAAAT GTCGTCATAC AGCTGCCCGG CGGCAGGCGG GTTACGCTTG 1151 ACAGGCGCGCCTTGGGTTTT GCGGCCCGCG CGGTCAATAA TGAAAAAATG 1201 GGGGAGGACC GTATCCGCAGGGGCGCGGTC ATCCGTGTCA AAAACAACGG 1251 CGGGCGTTGG GCGGTGGTTC AAGAGCCGTTGCTGCAGGGG GCTTTGGGTT 1301 CGCTGGATGC AAAAACCGGA GCTGTGCGCG CGCTGGTCGGCGGTTATGAT 1351 TTTCACAGCA AAACATTCAA TCGTGCCGTT CAGGCAATGC GGCAGCCGGG1401 TTCGACCTTT AAGCCGTTTG TCTATTCGGC GGCATTATCT AAGGGGATGA 1451CCGCGTCCAC AGTGGTTAAC GATGCGCCGA TTTCCCTGCC GGGGAAAGGG 1501 CCGAACGGTTCGGTTTGGAC ACCTAAAAAT TCAGACGGCA GATATTCCGG 1551 CTACATTACT TTGAGACAGGCTCTGACGGC TTCCAAGAAT ATGGTTTCCA 1601 TCCGTATTTT GATGTCTATC GGTGTCGGTTACGCGCAACA GTATATCCGG 1651 CGTTTCGGCT TCAGGTCGTC CGAGCTGCCG GCAAGCCTGTCTATGGCTTT 1701 AGGTACGGGC GAGACAACGC CGTTGAAAGT GGCGGAGGCA TATAGCGTAT1751 TTGCGAACGG CGGATATAGG GTTTCTTCGC ACGTAATCGA TAAGATTTAT 1801GACAGAGACG GCAGGTTGCG CGCCCAAATG CAACCTTTGG TGGCTGGGCA 1851 AAATGCGCCTCAGGCAATCG ATCCGCGCAA TGCCTATATT ATGTATAAGA 1901 TTATGCAGGA TGTGGTCCGTGTTGGTACGG CAAGGGGGGC AGCTGCGTTG 1951 GGAAGAACGG ATATTGCCGG TAAAACGGGTACGACCAATG ACAATAAGGA 2001 TGCGTGGTTT GTCGGTTTTA ACCCTGATGT GGTTACTGCCGTATATATCG 2051 GCTTCGACAA ACCTAAGAGT ATGGGGCGTG TCGGCTACGG CGGTACGATT2101 GCGGTGCCGG TTTGGGTGGA CTATATGCGT TTTGCGTTGA AAGGAAAGCA 2151GGGCAAGGGG ATGAAAATGC CTGAAGGTGT GGTCAGCAGC AATGGCGAAT 2201 ACTATATGAAGGAACGTATG GTAACCGATC CGGGCTTGAC GCTGGACAAC 2251 AGCGGTATTG CGCCGCAACCTTCCCGACGG GCAAAAGAAG ATGACGGGGG 2301 CGCGGCAGAA GGCGGACGGC AGGCGGCGGATGACGAAGTC CGCCAAGATA 2351 TGCAGGAAAC GCCGGTGCTT CCGAGTAATA CTGGTTCCAAACAGCAGCAG 2401 TTGGATTCTC TGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 2678; ORF 791>.

m791.pep 1 MVNYYSAMIK KILTTCFGLV FGFCVFGVGL VAIAILVTYP KLPSLDSLQH 51YQPKMPLTIY SADGEVIGMY GEQRREFTKI GDFPEVLRNA VIAAEDKRFY 101 RHWGVDVWGVARAAVGNVVS GSVQSGASTI TQQVAKNFYL SSEKTFTRKF 151 NEVLLAYKIE QSLSKDKILELYFNQIYLGQ RAYGFASAAQ IYFNKNVRDL 201 TLAEAAMLAG LPKAPSAYNP IVNPERAKLRQKYILNNMLE EKMITVQQRD 251 QALNEELHYE RFVRKIDQSA LYVAEMVRQE LYEKYGEDAYTQGFKVYTTV 301 RADHQKVATE ALRKALRNFD RGSSYRGAEN YIDLSKSEDV EETVSQYLSG351 LYTVDKMVPA VVLDVTKKKN VVIQLPGGRR VTLDRRALGF AARAVNNEKM 401GEDRIRRGAV IRVKNNGGRW AVVQEPLLQG ALGSLDAKTG AVRALVGGYD 451 FHSKTFNRAVQAMRQPGSTF KPFVYSAALS KGMTASTVVN DAPISLPGKG 501 PNGSVWTPKN SDGRYSGYITLRQALTASKN MVSIRILMSI GVGYAQQYIR 551 RFGFRSSELP ASLSMALGTG ETTPLKVAEAYSVFANGGYR VSSHVIDKIY 601 DRDGRLRAQM QPLVAGQNAP QAIDPRNAYI MYKIMQDVVRVGTARGAAAL 651 GRTDIAGKTG TTNDNKDAWF VGFNPDVVTA VYIGFDKPKS MGRVGYGGTI701 AVPVWVDYMR FALKGKQGKG MKMPEGVVSS NGEYYMKERM VTDPGLTLDN 751SGIAPQPSRR AKEDDGGAAE GGRQAADDEV RQDMQETPVL PSNTGSKQQQ 801 LDSLF*g791/m791 97.3% identity in 805 aa overlap        10        20        30        40        50        60 g791.pepMVNYYSAMIKKILTTCFGLFFGFCVFGVGLVAIAILVTYPKLPSLDSLQHYQPKMPLTIY||||||||||||||||||| |||||||||||||||||||||||||||||||||||||||| m791MVNYYSAMIKKILTTCFGLVFGFCVFGVGLVAIAILVTYPKLPSLDSLQHYQPKMPLTIY        10        20        30        40        50        60        70        80        90       100       110       120 g791.pepSADGEVIGMYGEQRREFTKIGDFFEVLRNAVIAAEDKRFYRHWGVDVWGVARAAVGNVVS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791SADGEVIGMYGEQRREFTKIGDFFEVLRNAVIAAEDKRFYRHWGVDVWGVARAAVGNVVS        70        80        90       100       110       120       130       140       150       160       170       180 g791.pepGSVQSGASTITQQVAKNFYLSSEKTFTRKFNEVLLAYKIEQSLSKDKILELYFNQIYLGQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791GSVQSGASTITQQVAKNFYLSSEKTFTRKFNEVLLAYKIEQSLSKDKILELYFNQIYLGQ       130       140       150       160       170       180       190       200       210       220       230       240 g791.pepRAYGFASAAQIYFNKNVRDLTLAEAAMLAGLPKAPSAYNPIVNPERAKLRQKYILNNMLE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791RAYGFASAAQIYFNKNVRDLTLAEAAMLAGLPKAPSAYNPIVNPERAKLRQKYILNNMLE       190       200       210       220       230       240       250       260       270       280       290       300 g791.pepEKMITVQQRDQALNEELHYERFVRKIDQSALYVAEMVRRELYEKYGEDAYTQGFKVYTTV||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||| m791EKMITVQQRDQALNEELHYERFVRKIDQSALYVAEMVRQELYEKYGEDAYTQGFKVYTTV       250       260       270       280       290       300       310       320       330       340       350       360 g791.pepRTDHQKAATEALRKALRNFDRGSSYRGAENYIDLSKSEDVEETVSQYLSGLYTVDKMVPA|:||||:||||||||||||||||||||||||||||||||||||||||||||||||||||| m791RADHQKVATEALRKALRNFDRGSSYRGAENYIDLSKSEDVEETVSQYLSGLYTVDKMVPA       310       320       330       340       350       360       370       380       390       400       410       420 g791.pepVVLDVTKKKNVVIQLPGGRRVALDRRALGFAARAVDNEKMGEDRIRRGAVIRVKNNGGRW|||||||||||||||||||||:|||||||||||||:|||||||||||||||||||||||| m791VVLDVTKKKNVVIQLPGGRRVTLDRRALGFAARAVNNEKMGEDRIRRGAVIRVKNNGGRW       370       380       390       400       410       420       430       440       450       460       470       480 g791.pepAVVQEPLLQGALVSLDAKTGAVRALVGGYDFHSKTFNRAVQAMRQPGSTFKPFVYSAALS|||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||| m791AVVQEPLLQGALGSLDAKTGAVRALVGGYDFHSKTFNRAVQAMRQPGSTFKPFVYSAALS       430       440       450       460       470       480       490       500       510       520       530       540 g791.pepKGMTASTVVNDAPISLPGKGPNGSVWTPKNSDGRYSGYITLRQALTASKNMVSIRILMSI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791KGMTASTVVNDAPISLPGKGPNGSVWTPKNSDGRYSGYITLRQALTASKNMVSIRILMSI       490       500       510       520       530       540       550       560       570       580       590       600 g791.pepGVGYAQQYIRRFGFRPSELPASLSMALGTGETTPLKVAEAYSVFANGGYRVSSHVIDKIY||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| m791GVGYAQQYIRRFGFRSSELPASLSMALGTGETTPLKVAEAYSVFANGGYRVSSHVIDKIY       550       560       570       580       590       600       610       620       630       640       650       660 g791.pepRDGRLRAQMQPLVAGQNAPQAIDPRNAYIMYKIMQDVVRVGLARGAAALGRTDIAGKTG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791DRDGRLRAQMQPLVAGQNAPQAIDPRNAYIMYKIMQDVVRVGLARGAAALGRTDIAGKTG       610       620       630       640       650       660       670       680       690       700       710       720 g791.pepTNDNKDAWFVGFNPDVVTAVYIGFDKPKSMGRAGYGGLIAVPVWVDYMRFALKGKQGKG|||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||| m791TTNDNKDAWFVGFNPDVVTAVYIGFDKPKSMGRVGYGGTIAVPVWVDYMRFALKGKQGKG       670       680       690       700       710       720       730       740       750       760       770       780 g791.pepKMPEGVVSSNGEYYMKERMVTDPGLMLDNSGIAPQPSRRAKEDDEAAVENEQQGRSDET|||||||||||||||||||||||||| |||||||||||||||||| :|:|: :|: :||: m791MKMPEGVVSSNGEYYMKERMVTDPGLTLDNSGIAPQPSRRAKEDDGGAAEGGRQAADDEV       730       740       750       760       770       780       790       800 g791.pep RQDVQETPVLPSNTDSKQQQLDSLFX|||:|||||||||| ||||||||||| m791 RQDMQETPVLPSNTGSKQQQLDSLFX       790       800The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2679>:

a791.seq 1 ATGGTAAATT ATTATTCAGC TATGATTAAA AAGATTTTAA CGACTTGTTT 51TGGTTTGGTT TTTGGGTTTT GTGTATTTGG AGTGGGTTTG GTTGCCATTG 101 CTATTTTGGTAACGTATCCG AAACTGCCGT CTTTGGATTC TTTGCAGCAT 151 TACCAGCCTA AAATGCCGTTGACTATTTAT TCGGCGGATG GGGAAGTCAT 201 CGGTATGTAT GGGGAGCAGC GGCGCGAATTTACAAAAATC GGCGATTTCC 251 CAGAGGTGTT GCGGAATGCG GTTATCGCCG CCGAGGATAAACGCTTTTAC 301 CGGCATTGGG GGGTGGATGT TTGGGGTGTT GCCCGCGCTG CCGTCGGCAA351 TGTCGTGTCC GGCAGCGTGC AGTCGGGTGC GAGTACGATT ACGCAGCAGG 401TGGCGAAAAA TTTTTATTTG AGCAGTGAAA AAACGTTCAC ACGCAAATTC 451 AATGAGGTGTTGCTTGCCTA TAAAATCGAG CAGTCTTTAA GCAAAGACAA 501 AATCCTCGAG TTGTATTTCAATCAGATTTA CCTCGGTCAG CGCGCCTATG 551 GTTTTGCATC TGCCGCGCAA ATCTATTTCAATAAGAATGT CCGAGATTTG 601 ACTTTGGCGG AAGCCGCCAT GCTTGCGGGA CTGCCCAAGGCTCCGTCTGC 651 CTATAATCCG ATTGTTAATC CAGAACGTGC CAAGTTGCGC CAGAAGTATA701 TTTTGAACAA TATGCTCGAG GAGAAGATGA TTACCGTGCA ACAGCGCGAT 751CAGGCGTTGA ATGAGGAACT GCATTACGAG CGGTTTGTTC GGAAAATCGA 801 TCAGAGTGCTTTATATGTGG CGGAAATGGT GCGTCAGGAA CTGTATGAGA 851 AATACGGTGA AGATGCCTATACGCAGGGTT TTAAGGTTTA TACCACGGTC 901 CGCGCCGATC ATCAGAAGGT GGCAACCGAGGCATTGCGCA AGGCTCTACG 951 GAATTTCGAT CGCGGCAGCA GCTACCGCGG TGCGGAAAACTATATCGATT 1001 TGAGTAAGAG TGAAGATGTC GAGGAGACTG TCAGCCAGTA TCTGTCGGGA1051 CTCTATACCG TCGATAAAAT GGTTCCCGCC GTTGTGTTGG ATGTGACTAA 1101AAAGAAAAAT GTCGTCATAC AGCTGCCCGG CGGCAGGCGG GTTACGCTTG 1151 ACAGGCGCGCCTTGGGTTTT GCGGCCCGCG CGGTCAATAA TGAAAAAATG 1201 GGGGAGGACC GTATCCGCAGGGGCGCGGTC ATCCGTGTCA AAAACAACGG 1251 CGGGCGTTGG GCGGTGGTTC AAGAGCCGTTGCTGCAGGGG GCTTTGGTTT 1301 CGCTGGATGC AAAAACCGGA GCTGTGCGCG CGCTGGTCGGCGGTTATGAT 1351 TTTCACAGCA AAACATTCAA TCGTGCCGTT CAGGCAATGC GGCAGCCGGG1401 TTCGACCTTT AAGCCGTTTG TCTATTCGGC GGCATTATCT AAGGGGATGA 1451CCGCGTCCAC AGTGGTTAAC GATGCGCCGA TTTCCCTGCC GGGGAAAGGG 1501 CCGAACGGTTCGGTTTGGAC ACCTAAAAAT TCAGACGGCA GATATTCCGG 1551 CTACATTACT TTGAGACAGGCTCTGACGGC TTCCAAGAAT ATGGTTTCCA 1601 TCCGTATTTT GATGTCTATC GGTGTCGGTTACGCGCAACA GTATATCCGG 1651 CGTTTCGGCT TCAGGTCGTC CGAGCTGCCG GCAAGCCTGTCTATGGCTTT 1701 AGGTACGGGC GAGACAACGC CGTTGAAAGT GGCGGAGGCA TATAGCGTAT1751 TTGCGAACGG CGGATATAGG GTTTCTTCGC ACGTAATCGA TAAGATTTAT 1801GACAGAGACG GCAGGTTGCG CGCCCAAATG CAACCTTTGG TGGCCGGGCA 1851 AAATGCGCCTCAGGCAATCG ATCCGCGCAA TGCCTATATT ATGTATAAGA 1901 TTATGCAGGA TGTGGTCCGTGTTGGTACGG CAAGGGGGGC AGCTGCGTTG 1951 GGAAGAACGG ATATTGCCGG TAAAACGGGTACGACCAATG ACAATAAGGA 2001 TGCGTGGTTT GTCGGTTTTA ACCCTGATGT GGTTACTGCCGTATATATCG 2051 GCTTCGACAA ACCTAAGAGT ATGGGGCGTG TCGGCTACGG CGGTACGATT2101 GCGGTGCCGG TTTGGGTGGA CTATATGCGT TTTGCGTTGA AAGGAAAGCA 2151GGGCAAGGGG ATGAAAATGC CTGAAGGTGT GGTCAGCAGC AATGGCGAAT 2201 ACTATATGAAGGAACGTATG GTAACCGATC CGGGCTTGAC GCTGGACAAC 2251 AGCGGTATTG CGCCGCAACCTTCCCGACGG GCAAAAGAAG ATGACGGGGG 2301 CGCGGCAGAA GGCGGACGGC AGGCGGCGGATGACGAAGTC CGCCAAGATA 2351 TGCAGGAAAC GCCGGTGCTT CCGAGTAATA CTGGTTCCAAACAGCAGCAG 2401 TTGGATTCTC TGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 2680; ORF 791.a>:

a791.pep 1 MVNYYSAMIK KILTTCFGLV FGFCVFGVGL VAIAILVTYP KLPSLDSLQH 51YQPKMPLTIY SADGEVIGMY GEQRREFTKI GDFPEVLRNA VIAAEDKRFY 101 RHWGVDVWGVARAAVGNVVS GSVQSGASTI TQQVAKNFYL SSEKTFTRKF 151 NEVLLAYKIE QSLSKDKILELYFNQIYLGQ RAYGFASAAQ IYFNKNVRDL 201 TLAEAAMLAG LPKAPSAYNP IVNPERAKLRQKYILNNMLE EKMITVQQRD 251 QALNEELHYE RFVRKIDQSA LYVAEMVRQE LYEKYGEDAYTQGFKVYTTV 301 RADHQKVATE ALRKALRNFD RGSSYRGAEN YIDLSKSEDV EETVSQYLSG351 LYTVDKMVPA VVLDVTKKKN VVIQLPGGRR VTLDRRALGF AARAVNNEKM 401GEDRIRRGAV IRVKNNGGRW AVVQEPLLQG ALVSLDAKTG AVRALVGGYD 451 FHSKTFNRAVQAMRQPGSTF KPFVYSAALS KGMTASTVVN DAPISLPGKG 501 PNGSVWTPKN SDGRYSGYITLRQALTASKN MVSIRILMSI GVGYAQQYIR 551 RFGFRSSELP ASLSMALGTG ETTPLKVAEAYSVFANGGYR VSSHVIDKIY 601 DRDGRLRAQM QPLVAGQNAP QAIDPRNAYI MYKIMQDVVRVGTARGAAAL 651 GRTDIAGKTG TTNDNKDAWF VGFNPDVVTA VYIGFDKPKS MGRVGYGGTI701 AVPVWVDYMR FALKGKQGKG MKMPEGVVSS NGEYYMKERM VTDPGLTLDN 751SGIAPQPSRR AKEDDGGAAE GGRQAADDEV RQDMQETPVL PSNTGSKQQQ 801 LDSLF*a791/m791 99.9% identity in 805 aa overlap        10        20        30        40        50        60 a791.pepMVNYYSAMIKKILTTCFGLVFGFCVFGVGLVAIAILVTYPKLPSLDSLQHYQPKMPLTIY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791MVNYYSAMIKKILTTCFGLVFGFCVFGVGLVAIAILVTYPKLPSLDSLQHYQPKMPLTIY        10        20        30        40        50        60        70        80        90       100       110       120 a791.pepSADGEVIGMYGEQRREFTKIGDFPEVLRNAVIAAEDKRFYRHWGVDVWGVARAAVGNVVS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791SADGEVIGMYGEQRREFTKIGDFPEVLRNAVIAAEDKRFYRHWGVDVWGVARAAVGNVVS        70        80        90       100       110       120       130       140       150       160       170       180 a791.pepGSVQSGASTITQQVAKNFYLSSEKTFTRKFNEVLLAYKIEQSLSKDKILELYFNQIYLGQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791GSVQSGASTITQQVAKNFYLSSEKTFTRKFNEVLLAYKIEQSLSKDKILELYFNQIYLGQ       130       140       150       160       170       180       190       200       210       220       230       240 a791.pepRAYGFASAAQIYFNKNVRDLTLAEAAMLAGLPKAPSAYNPIVNPERAKLRQKYILNNMLE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791RAYGFASAAQIYFNKNVRDLTLAEAAMLAGLPKAPSAYNPIVNPERAKLRQKYILNNMLE       190       200       210       220       230       240       250       260       270       280       290       300 a791.pepEKMITVQQRDQALNEELHYERFVRKIDQSALYVAEMVRQELYEKYGEDAYTQGFKVYTTV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791EKMITVQQRDQALNEELHYERFVRKIDQSALYVAEMVRQELYEKYGEDAYTQGFKVYTTV       250       260       270       280       290       300       310       320       330       340       350       360 a791.pepRADHQKVATEALRKALRNFDRGSSYRGAENYIDLSKSEDVEETVSQYLSGLYTVDKMVPA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791RADHQKVATEALRKALRNFDRGSSYRGAENYIDLSKSEDVEETVSQYLSGLYTVDKMVPA       310       320       330       340       350       360       370       380       390       400       410       420 a791.pepVVLDVTKKKNVVIQLPGGRRVTLDRRALGFAARAVNNEKMGEDRIRRGAVIRVKNNGGRW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791VVLDVTKKKNVVIQLPGGRRVTLDRRALGFAARAVNNEKMGEDRIRRGAVIRVKNNGGRW       370       380       390       400       410       420       430       440       450       460       470       480 a791.pepAVVQEPLLQGALVSLDAKTGAVRALVGGYDFHSKTFNRAVQAMRQPGSTFKPFVYSAALS|||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||| m791AVVQEPLLQGALGSLDAKTGAVRALVGGYDFHSKTFNRAVQAMRQPGSTFKPFVYSAALS       430       440       450       460       470       480       490       500       510       520       530       540 a791.pepKGMTASTVVNDAPISLPGKGPNGSVWTPKNSDGRYSGYITLRQALTASKNMVSIRILMSI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791KGMTASTVVNDAPISLPGKGPNGSVWTPKNSDGRYSGYITLRQALTASKNMVSIRILMSI       490       500       510       520       530       540       550       560       570       580       590       600 a791.pepGVGYAQQYIRRFGFRSSELPASLSMALGTGETTPLKVAEAYSVFANGGYRVSSHVIDKIY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791GVGYAQQYIRRFGFRSSELPASLSMALGTGETTPLKVAEAYSVFANGGYRVSSHVIDKIY       550       560       570       580       590       600       610       620       630       640       650       660 a791.pepDRDGRLRAQMQPLVAGQNAPQAIDPRNAYIMYKIMQDVVRVGTARGAAALGRTDIAGKTG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791DRDGRLRAQMQPLVAGQNAPQAIDPRNAYIMYKIMQDVVRVGTARGAAALGRTDIAGKTG       610       620       630       640       650       660       670       680       690       700       710       720 a791.pepTTNDNKDAWFVGFNPDVVTAVYIGFDKPKSMGRVGYGGTIAVPVWVDYMRFALKGKQGKG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791TTNDNKDAWFVGFNPDVVTAVYIGFDKPKSMGRVGYGGTIAVPVWVDYMRFALKGKQGKG       670       680       690       700       710       720       730       740       750       760       770       780 a791.pepMKMPEGVVSSNGEYYMKERMVTDPGLTLDNSGIAPQPSRRAKEDDGGAAEGGRQAADDEV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m791MKMPEGVVSSNGEYYMKERMVTDPGLTLDNSGIAPQPSRRAKEDDGGAAEGGRQAADDEV       730       740       750       760       770       780       790       800 a791.pep RQDMQETPVLPSNTGSKQQQLDSLFX|||||||||||||||||||||||||| m791 RQDMQETPVLPSNTGSKQQQLDSLFX       790       800The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2681>:

g792.seq 1 ATGTTCCGCA TCGTCAAATG GCTGATTGCC CTGCCCGTCG GCATCTTTAT 51CTTTTTCAAT GCCTATGTGT ACGGCAACAT CATCACCTAC CGCGCCGTCG 101 CGCCCCATCGGACTGCCTTT ATGTCGATGC GGATGAAGCA GTTTGAACAA 151 GAAGGTCGCG ATGTCGCACTGGATTACCGC TGGGTGCCCT ACAACCGCAT 201 TTCCACCAAC CTGAAAAAAG CCCTGATTGCTTCCGAAGAT GTCCGTTTTG 251 CCggacacgg gggcttcGat GGGGACGGCa tTCAAAACGCCATCAGGCGC 301 AACCGGAACA GCGGCGAAGT GAAGGCGGGC GGATCGACCA TCAGCCAGCA351 GCTTGCCAAA AACCTCTTCC TCAACGAAAG CCGCAACTAT CTGCGCAAAG 401GGGAAGAGGC GGCCATTACG GCAATGATGG AAGCTGTTAC CGACAAAAAC 451 AGGATTTTCGAACTGTATTT AAACTCAATC GAATGGCACT ACGGCgtTTT 501 CGGCGCGGAA GCTGCGTCCCGGtatTttTA TAAAAAACCG GCcgcaGACC 551 TGACcAAACA GCAggcggcG aaactgacggtactcgtccc cgccccgttt 601 tactactctg accatccaaa aagcaaacgg ctgcgcaacaaaaccaatat 651 cgtgctcaga cgcatgggtt cggcaaatta ccccaaagcg aaacggactg701 attgttccag atatggaaat gccgcctgaa ctggggttcg aacggcatat 751gttttctggg acttataaThis corresponds to the amino acid sequence <SEQ ID 2682; ORF 792.ng>:

g792.pep 1 MFRIVKWLIA LPVGIFIFFN AYVYGNIITY RAVAPHRTAF MSMRMKQFEQ 51EGRDVALDYR WVPYNRISTN LKKALIASED VRFAGHGGFD GDGIQNAIRR 101 NRNSGEVKAGGSTISQQLAK NLFLNESRNY LRKGEEAAIT AMMEAVTDKN 151 RIFELYLNSI EWHYGVFGAEAASRYFYKKP AADLTKQQAA KLTVLVPAPF 201 YYSDHPKSKR LRNKTNIVLR RMGSANYPKAKRTDCSRYGN AA*TGVRTAY 251 VFWDL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2683>:

m792.seq 1 ATGTTCCGCA TCATCAAATG GCTGATTGCC CTGCCCGTCG GCATCTTTAT 51CTTTTTCAAT GCCTATGTGT ACGGCAACAT CATTACCTAC CGCGCCGTCG 101 CGCCCCATCGGACTGCCTTT ATGTCGATGC GGATGAAGCA GTTTGAACAG 151 GAAGGTCGCG ATGTCGCACTGGATTACCGC TGGATGCCCT ACAAACGCAT 201 TTCCACCAAC CTGAAAAAAG CCCTGATTGCTTCCGAAGAT GCCCGTTTCG 251 CCGGGCACGG CGGCTTCGAT TGGGGCGGCA TTCAAAACGCCATCAGGCGC 301 AACCGGAACA GCGGCAAAGT GAAGGCGGGC GGCTCGACCA TCAGCCAGCA351 GCTTGCCAAA AACCTGTTTT TAAACGAAAG CCGCAGCTAT ATCCGCAAAG 401GCGAAGAAGC GGCGATTACC GCGATGATGG AAGCCGTTAC CGACAAAGAC 451 AGGATTTTTGAACTGTATTT AAACTCAATC GAATGGCACT ACGGCGTTTT 501 CGGCGCGGAA GCCGCGTCCCGGTATTTTTA TCAAATACCC GCCGCCAAGC 551 TGACCAAACA GCAGGCGGCA AAACTGACGGCGCGCGTCCC CGCCCCGCTC 601 TACTACGCCG ACCATCCGAA AAGCAAACGG CTCCGCAACAAAACCAATAT 651 CGTGCTCAAA CGCATGGGTT CGGCAGAGTT GCCTGAAAGC GACACGGACT701 GAThis corresponds to the amino acid sequence <SEQ ID 2684; ORF 792>:

m792.pep 1 MFRIIKWLIA LPVGIFIFFN AYVYGNIITY RAVAPHRTAF MSMRMKQFEQ 51EGRDVALDYR WMPYKRISTN LKKALIASED ARFAGHGGFD WGGIQNAIRR 101 NRNSGKVKAGGSTISQQLAK NLFLNESRSY IRKGEEAAIT AMMEAVTDKD 151 RIFELYLNSI EWHYGVFGAEAASRYFYQIP AAKLTKQQAA KLTARVPAPL 201 YYADHPKSKR LRNKTNIVLK RMGSAELPESDTD* g792/m792 90.4% identity in 230 aa overlap        10        20        30        40        50        60 g792.pepMFRIVKWLIALPVGIFIFFNAYVYGNIITYRAVAPHRTAFMSMRMKQFEQEGRDVALDYR||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||| m792MFRIIKWLIALPVGIFIFFNAYVYGNIITYRAVAPHRTAFMSMRMKQFEQEGRDVALDYR        10        20        30        40        50        60        70        80        90       100       110       120 g792.pepWVPYNRISTNLKKALIASEDVRFAGHGGFDGDGIQNAIRRNRNSGEVKAGGSTISQQLAK|:||:|||||||||||||||:|||||||||  |||||||||||||:|||||||||||||| m792WMPYKRISTNLKKALIASEDARFAGHGGFDWGGIQNAIRRNRNSGKVKAGGSTISQQLAK        70        80        90       100       110       120       130       140       150       160       170       180 g792.pepNLFLNESRNYLRKGEEAAITAMMEAVTDKNRIFELYLNSIEWHYGVFGAEAASRYFYKKP||||||||:|:||||||||||||||||||:|||||||||||||||||||||||||||: | m792NLFLNESRSYIRKGEEAAITAMMEAVTDKDRIFELYLNSIEWHYGVFGAEAASRYFYQIP       130       140       150       160       170       180       190       200       210       220       230       240 g792.pepAADLTKQQAAKLTVLVPAPFYYSDHPKSKRLRNKTNIVLRRMGSANYPKAKRTDCSRYGN|| ||||||||||: ||||:||:||||||||||||||||:|||||: |:: m792AAKLTKQQAAKLTARVPAPLYYADHPKSKRLRNKTNIVLKRMGSAELPESDTDX       190       200       210       220       230        250 g792.pepAAXTGVRTAYVFWDLXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2685>:

a792.seq 1 ATGTTCCGCA TCATCAAATG GCTGATTGCC CTGCCCGTCG GCATCTTTAT 51CTTTTTCAAT GCCTATGTGT ACGGCAACAT CATTACCTAC CGCGCCGTCG 101 CGCCCCATCGGACTGCCTTT ATGTCGATGC GGATGAAGCA GTTTGAACAG 151 GAAGGTCGCG ATGTCGCACTGGATTACCGC TGGATGCCCT ACAAACGCAT 201 TTCCACCAAC CTGAAAAAAG CCCTGATTGCTTCCGAAGAT GCCCGTTTCG 251 CCGGGCACGG CGGCTTCGAT TGGGGCGGCA TTCAAAACGCCATCAGGCGC 301 AACCGGAACA GCGGCAAAGT GAAGGCGGGC GGCTCGACCA TCAGCCAGCA351 GCTTGCCAAA AACCTGTTTT TAAACGAAAG CCGCAGCTAT ATCCGCAAAG 401GCGAAGAAGC GGCGATTACC GCGATGATGG AAGCCGTTAC CGACAAAGAC 451 AGGATTTTTGAACTGTATTT AAACTCAATC GAATGGCACT ACGGCGTTTT 501 CGGCGCGGAA GCCGCGTCCCGGTATTTTTA TCAAATACCC GCCGCCAAGC 551 TGACCAAACA GCAGGCGGCA AAACTGACGGCGCGCGTCCC CGCCCCGCTC 601 TACTACGCCG ACCATCCGAA AAGCAAACGG CTCCGCAACAAAACCAATAT 651 CGTGCTCAGA CGCATGGGTT CGGCAGAGTT GCCTGAAAGC GACACGGACT701 GAThis corresponds to the amino acid sequence <SEQ ID 2686; ORF 792.a>:

a792.pep 1 MFRIIKWLIA LPVGIFIFFN AYVYGNIITY RAVAPHRTAF MSMRMKQFEQ 51EGRDVALDYR WMPYKRISTN LKKALIASED ARFAGHGGFD WGGIQNAIRR 101 NRNSGKVKAGGSTISQQLAK NLFLNESRSY IRKGEEAAIT AMMEAVTDKD 151 RIFELYLNSI EWHYGVFGAEAASRYFYQIP AAKLTKQQAA KLTARVPAPL 201 YYADHPKSKR LRNKTNIVLR RMGSAELPESDTD* m792/a792 99.6% identity in 233 aa overlap        10        20        30        40        50        60 a792.pepMFRIIKWLIALPVGIFIFFNAYVYGNIITYRAVAPHRTAFMSMRMKQFEQEGRDVALDYR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m792MFRIIKWLIALPVGIFIFFNAYVYGNIITYRAVAPHRTAFMSMRMKQFEQEGRDVALDYR        10        20        30        40        50        60        70        80        90       100       110       120 a792.pepWMPYKRISTNLKKALIASEDARFAGHGGFDWGGIQNAIRRNRNSGKVKAGGSTISQQLAK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m792WMPYKRISTNLKKALIASEDARFAGHGGFDWGGIQNAIRRNRNSGKVKAGGSTISQQLAK        70        80        90       100       110       120       130       140       150       160       170       180 a792.pepNLFLNESRSYIRKGEEAAITAMMEAVTDKDRIFELYLNSIEWHYGVFGAEAASRYFYQIP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m792NLFLNESRSYIRKGEEAAITAMMEAVTDKDRIFELYLNSIEWHYGVFGAEAASRYFYQIP       130       140       150       160       170       180       190       200       210       220       230 a792.pepAAKLTKQQAAKLTARVPAPLYYADHPKSKRLRNKTNIVLRRMGSAELPESDTDX|||||||||||||||||||||||||||||||||||||||:|||||||||||||| m792AAKLTKQQAAKLTARVPAPLYYADHPKSKRLRNKTNIVLKRMGSAELPESDTDX       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2687>:

g793.seq 1 ATGTTGATTA AAAGCGAATA TAAGCCCCGG ATGCTGCCCA AAGAAGAGCA 51GGTCAAAAAG CCGATGACCA GTAACGGACG GATTAGCTTC GTCCTGATGG 101 CAATGGCGGTCTTGTTTGCC TGTCTGATTG CCCGCGGGCT GTATCTGCAG 151 ACGGTAACGT ATAACTTTTTGAAAGAACAG GGCGACAACC GGATTGTGCG 201 GACTCAAGCA TTGCCGGCTA CACGCGGTACGGTTTCGGAC CGGAACGGTG 251 CGGTTTTGGC GTTGAGCGCG CCGACGGAGT CCCTGTTTGCCGTGCCTAAA 301 GATATGAAGG AAATGCCGTC TGCCGCCCAA TTGGAACGCC TGTCCGAGCT351 TGTCGATGTG CCGGTCGATG TTTTGAGGAA CAAACTCGAA CAGAAAGGCA 401AGTCGTTTAT TTGGATCAAG CGGCAGCTCG ATCCCAAGGT TGCCGAAGAG 451 GTCAAAGCCTTGGGTTTGGA AAACTTTGTA TTTGAAAAAG AATTAAAACG 501 CCATTACCCG ATGGGCAACCTGTTTGCACA CGTCATCGGA TTTACCGATA 551 TTGACGGCAA AGGTCAGGAA GGTTTGGAACTTTCGCTTGA AGACAGCCTG 601 TATGGCGAAG ACGGCGCGGA AGTTGTTTTG CGGGACCGGCAGGGCAATAT 651 TGTGGACAGC TTGGACTCCC CGCGCAATAA AGCACCGCAA AACGGCAAAG701 ACATCATCCT TTCCCTCGAT CAGAGGATTC AGACCTTGGC CTATGAAGAG 751TTGAACAAGG CGGTCGAATA CCATCAGGCA AAAGCCGGAA CGGTGGTGGT 801 TTTGGATGCCCGCACGGGGG AAATCCTCGC CTTGGCCAAT ACGCCCGCCT 851 ACGATCCCAA CAGACCCGGCCGGGCAGACA GCGAACAGCG GCGCAACCGT 901 GCCGTAACCG ATATGATCGA ACCTGGTTCGGCAATCAAAC CGTTCGTGAT 951 TGCGAAGGCA TTGGATGCGG GCAAAACCGA TTTGAACGAACGGCTGAATA 1001 CGCAGCCTTA TAAAATCGGA CCGTCTCCCG TGCGCGATGA TACCCATGTT1051 TACCCCTCTT TGGATGTGCG CGGCATTATG CAGAAATCGT CCAACGTCGG 1101CACAAGCAAA CTGTCTGCGC GTTTCGGCGC CGAAGAAATG TATGACTTCT 1151 ATCATGAATTGGGCATCGGT GTGCGTATGC ACTCGGGCTT TCCGGGGGAA 1201 ACTGCAGGTT TGTTGAGAAATTGGCGCAGG TGGCGGCCCA TCGAACAGGC 1251 GACGATGTCT TTCGGTTACG GTCTGCAATTGAGCCTGCTG CAATTGGCGC 1301 GCGCCTATAC CGCACTGACG CACGACGGCG TTTTGCTGCCGCTCAGCTTT 1351 GAGAAGCAGG CGGTTGCGCC GCAAGGCAAA CGCATATTCA AAGAATCGAC1401 CGCGCGCGAG GTACGCAATC TGATGGTTTC CGTAACCGAG CCGGGCGGCA 1451CCGGTACGGC GGGTGCGGTG GACGGTTTCG ATGTCGGCGC TAAAACCGGC 1501 ACGGCGCGCAAGTTCGTCAA CGGGCGTTAT GCCGACAACA AACACGTCGC 1551 TACCTTTATC GGTTTTGCCCCCGCCAAAAA CCCCCGTGTG ATTGTGGCGG 1601 TAACCATCGA CGAACCGACT GCCCACGGCTATTACGGCGG CGTAGTGGCA 1651 GGGCCGCCCT TCAAAAAAAT TATGGGCGGC AGCCTGAACATCTTGGGCAT 1701 TTCCCCGACC AAGCCACTGA CCGCCGCAGC CGTCAAAACA CCGTCTTAAThis corresponds to the amino acid sequence <SEQ ID 2688; ORF 793.ng>:

g793.pep 1 MLIKSEYKPR MLPKEEQVKK PMTSNGRISF VLMAMAVLFA CLIARGLYLQ 51TVTYNFLKEQ GDNRIVRTQA LPATRGTVSD RNGAVLALSA PTESLFAVPK 101 DMKEMPSAAQLERLSELVDV PVDVLRNKLE QKGKSFIWIK RQLDPKVAEE 151 VKALGLENFV FEKELKRHYPMGNLFAHVIG FTDIDGKGQE GLELSLEDSL 201 YGEDGAEVVL RDRQGNIVDS LDSPRNKAPQNGKDIILSLD QRIQTLAYEE 251 LNKAVEYHQA KAGTVVVLDA RTGEILALAN TPAYDPNRPGRADSEQRRNR 301 AVTDMIEPGS AIKPFVIAKA LDAGKTDLNE RLNTQPYKIG PSPVRDDTHV351 YPSLDVRGIM QKSSNVGTSK LSARFGAEEM YDFYHELGIG VRMHSGFPGE 401TAGLLRNWRR WRPIEQATMS FGYGLQLSLL QLARAYTALT HDGVLLPLSF 451 EKQAVAPQGKRIFKESTARE VRNLMVSVTE PGGTGTAGAV DGFDVGAKTG 501 TARKFVNGRY ADNKHVATFIGFAPAKNPRV IVAVTIDEPT AHGYYGGVVA 551 GPPFKKIMGG SLNILGISPT KPLTAAAVKTPS*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2689>:

m793.seq 1 ATGTTGATTA AGAGCGAATA TAAGCCTCGG ATGCTGCCCA AAGAAGAGCA 51GGTCAAAAAG CCGATGACCA GTAACGGACG GATCAGCTTC GTCCTGATGG 101 CAATAGCGGTCTTGTTTGCC GGTCTGATTG CTCGCGGACT GTATCTGCAG 151 ACGGTAACGT ATAACTTTTTGAAAGAACAG GGCGACAACC GGATTGTGCG 201 GACTCAAACA TTGCCGGCTA CACGCGGTACGGTTTCGGAC CGGAACGGTG 251 CGGTTTTGGC GTTGAGTGCG CCGACGGAGT CCCTGTTTGCCGTGCCTAAA 301 GAGATGAAGG AAATGCCGTC TGCCGCACAA TTGGAACGCC TGTCCGAGCT351 TGTCGATGTG CCGGTTGATG TTTTGAGGAA CAAGCTCGAA CAGAAAGGCA 401AGTCGTTTAT CTGGATTAAG CGGCAGCTCG ATCCCAAGGT TGCCGAAGAG 451 GTCAAAGCCTTGGGTTTGGA AAACTTTGTA TTTGAAAAAG AATTAAAACG 501 CCATTACCCG ATGGGCAACCTGTTTGCACA CGTCATCGGA TTTACCGATA 551 TTGACGGCAA AGGTCAGGAA GGTTTGGAACTTTCGCTTGA AGACAGCCTG 601 CATGGCGAAG ACGGCGCGGA AGTCGTTTTG CGGGACCGGCAGGGCAATAT 651 TGTGGACAGC TTGGACTCCC CGCGCAATAA AGCCCCGAAA AACGGCAAAG701 ACATCATCCT TTCCCTCGAT CAGAGGATTC AGACCTTGGC CTATGAAGAG 751TTGAACAAGG CGGTCGAATA CCATCAGGCA AAAGCCGGAA CGGTGGTGGT 801 TTTGGATGCCCGCACGGGGG AAATCCTCGC CTTGGCCAAT ACGCCCGCCT 851 ACGATCCCAA CAGGCCCGGCCGGGCAGACA GCGAACAGCG GCGCAACCGT 901 GCCGTAACCG ATATGATCGA ACCCGGTTCGGCAATCAAAC CGTTTGTGAT 951 TGCGAAGGCA TTGGATGCGG GCAAAACCGA TTTGAACGAACGGCTGAATA 1001 CGCAGCCTTA TAAAATCGGA CCGTCTCCCG TGCGCGATAC CCATGTTTAC1051 CCCTCTTTGG ATGTGCGCGG CATCATGCAG AAATCGTCCA ACGTCGGCAC 1101AAGCAAACTG TCTGCGCGTT TCGGTGCCGA AGAAATGTAT GACTTCTATC 1151 ATGAGTTGGGCATCGGTGTG CGTATGCACT CGGGCTTTCC GGGCGAAACT 1201 GCAGGTTTGT TGAGAAATTGGCGCAGGTGG CGGCCTATCG AACAGGCGAC 1251 GATGTCTTTC GGTTACGGCC TGCAATTGAGCCTGCTGCAA TTGGCGCGCG 1301 CCTATACCGC ACTGACGCAC GACGGCGTTT TACTGCCGGTCAGCTTTGAA 1351 AAACAGGCGG TTGCGCCGCA AGGCAAACGC ATATTCAAAG AATCGACCGC1401 GCGCGAGGTA CGCAATCTGA TGGTTTCCGT AACCGAGCCG GGCGGCACCG 1451GTACGGCGGG TGCGGTGGAC GGTTTCGATG TCGGCGCGAA AACCGGCACG 1501 GCGCGCAAGTTCGTCAACGG GCGTTATGCC GACAACAAAC ACATCGCTAC 1551 CTTTATCGGT TTTGCCCCCGCCAAAAATCC CCGTGTGATT GTGGCGGTAA 1601 CCATTGACGA ACCGACTGCC CACGGTTATTACGGCGGCGT AGTGGCAGGG 1651 CCGCCCTTCA AAAAAATTAT GGGCGGCAGC CTGAACATCTTGGGCATTTC 1701 CCCGACCAAG CCACTGACCG CCGCAGCCGT CAAAACACCG TCTTAAThis corresponds to the amino acid sequence <SEQ ID 2690; ORF 793>:

m793.pep 1 MLIKSEYKPR MLPKEEQVKK PMTSNGRISF VLMAIAVLFA GLIARGLYLQ 51TVTYNFLKEQ GDNRIVRTQT LPATRGTVSD RNGAVLALSA PTESLFAVPK 101 EMKEMPSAAQLERLSELVDV PVDVLRNKLE QKGKSFIWIK RQLDPKVAEE 151 VKALGLENFV FEKELKRHYPMGNLFAHVIG FTDIDGKGQE GLELSLEDSL 201 HGEDGAEVVL RDRQGNIVDS LDSPRNKAPKNGKDIILSLD QRIQTLAYEE 251 LNKAVEYHQA KAGTVVVLDA RTGEILALAN TPAYDPNRPGRADSEQRRNR 301 AVTDMIEPGS AIKPFVIAKA LDAGKTDLNE RLNTQPYKIG PSPVRDTHVY351 PSLDVRGIMQ KSSNVGTSKL SARFGAEEMY DFYHELGIGV RMHSGFPGET 401AGLLRNWRRW RPIEQATMSF GYGLQLSLLQ LARAYTALTH DGVLLPVSFE 451 KQAVAPQGKRIFKESTAREV RNLMVSVTEP GGTGTAGAVD GFDVGAKTGT 501 ARKFVNGRYA DNKHIATFIGFAPAKNPRVI VAVTIDEPTA HGYYGGVVAG 551 PPFKKIMGGS LNILGISPTK PLTAAAVKTP S*g793/m793 98.5% identity in 582 aa overlap          10        20        30        40        50        60 g793.pep  MLIKSEYKPRMLPKEEQVKKPMTSNGRISFVLMAMAVLFACLIARGLYLQTVTYNFLKEQ  ||||||||||||||||||||||||||||||||||:||||| ||||||||||||||||||| m793  MLIKSEYKPRMLPKEEQVKKPMTSNGRISFVLMAIAVLFAGLIARGLYLQTVTYNFLKEQ          10        20        30        40        50        60          70        80        90       100       110       120 g793.pep  GDNRIVRTQALPATRGTVSDRNGAVLALSAPTESLFAVPKDMKEMPSAAQLERLSELVDV  |||||||||:||||||||||||||||||||||||||||||:||||||||||||||||||| m793  GDNRIVRTQLLPATRGTVSDRNGAVLALSAPTESLFAVPKEMKEMPSAAQLERLSELVDV          70        80        90       100       110       120         130       140       150       160       170       180 g793.pep  PVDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIG  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m793  PVDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIG         130       140       150       160       170       180         190       200       210       220       230       240 g793.pep  FTDIDGKGQEGLELSLEDSLYGEDGAEVVLRDRQGNIVDSLDSPRNKAPQNGKDIILSLD  ||||||||||||||||||||:||||||||||||||||||||||||||||:|||||||||| m793  FTDIDGKGQEGLELSLEDSLHGEDGAEVVLRDRQGNIVDSLDSPRNKAPKNGKDIILSLD         190       200       210       220       230       240         250       260       270       280       290       300 g793.pep  QRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPAYDPNRPGRADSEQRRNR  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m793  QRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPAYDPNRPGRADSEQRRNR         250       260       270       280       290       300         310       320       330       340       350       360 g793.pep  AVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDDTHVYPSLDVRGIM  |||||||||||||||||||||||||||||||||||||||||||||| ||||||||||||| m793  AVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRD-THVYPSLDVRGIM         310       320       330       340       350       360         370       380       390       400       410       420 g793.pep  QKSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMS  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m793  QKSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMS360     370       380       390       400       410         430       440       450       460       470       480 g793.pep  FGYGLQLSLLQLARAYTALTHDGVLLPLSFEKQAVAPQGKRIFKESTAREVRNLMVSVTE  |||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||| m793  FGYGLQLSLLQLARAYTALTHDGVLLPVSFEKQAVAPQGKRIFKESTAREVRNLMVSVTE420     430       440       450       460       470         490       500       510       520       530       540 g793.pep  PGGTGTAGAVDGFDVGAKTGTARKFVNGRYADNKHVATFIGFAPAKNPRVIVAVTIDEPT  |||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||| m793  PGGTGTAGAVDGFDVGAKTGTARKFVNGRYADNKHIATFIGFAPAKNPRVIVAVTIDEPT480     490       500       510       520       530         550       560       570       580 g793.pep  AHGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPSX  ||||||||||||||||||||||||||||||||||||||||||| m793  AHGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPSX540       550       560       570       580The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2691>:

a793.seq 1 ATGTTGATTA AGAGCGAATA TAAGCCTCGG ATGCTGCCCA AAGAAGAGCA 51GGTCAAAAAG CCGATGACCA GTAACGGACG GATCAGCTTC GTCCTGATGG 101 CAATAGCGGTCTTGTTTGCC GGTCTGATTG CTCGCGGACT GTATCTGCAG 151 ACGGTAACGT ATAACTTTTTGAAAGAACAG GGCGACAACC GGATTGTGCG 201 GACTCAAACA TTGCCGGCTA CACGCGGTACGGTTTCGGAC CGGAACGGTG 251 CGGTTTTGGC GTTGAGTGCG CCGACGGAGT CCCTGTTTGCCGTGCCTAAA 301 GAGATGAAGG AAATGCCGTC TGCCGCACAA TTGGAACGCC TGTCCGAGCT351 TGTCGATGTG CCGGTTGATG TTTTGAGGAA CAAGCTCGAA CAGAAAGGCA 401AGTCGTTTAT CTGGATTAAG CGGCAGCTCG ATCCCAAGGT TGCCGAAGAG 451 GTCAAAGCCTTGGGTTTGGA AAACTTTGTA TTTGAAAAAG AATTAAAACG 501 CCATTACCCG ATGGGCAACCTGTTTGCACA CGTCATCGGA TTTACCGATA 551 TTGACGGCAA AGGTCAGGAA GGTTTGGAACTTTCGCTTGA AGACAGCCTG 601 CATGGCGAAG ACGGCGCGGA AGTCGTTTTG CGGGACCGGCAGGGCAATAT 651 TGTGGACAGC TTGGACTCCC CGCGCAATAA AGCCCCGAAA AACGGCAAAG701 ACATCATCCT TTCCCTCGAT CAGAGGATTC AGACCTTGGC CTATGAAGAG 751TTGAACAAGG CGGTCGAATA CCATCAGGCA AAAGCCGGAA CGGTGGTGGT 801 TTTGGATGCCCGCACGGGGG AAATCCTCGC CTTGGCCAAT ACGCCCGCCT 851 ACGATCCCAA CAGGCCCGGCCGGGCAGACA GCGAACAGCG GCGCAACCGT 901 GCCGTAACCG ATATGATCGA ACCCGGTTCGGCAATCAAAC CGTTTGTGAT 951 TGCGAAGGCA TTGGATGCGG GCAAAACCGA TTTGAACGAACGGCTGAATA 1001 CGCAGCCTTA TAAAATCGGA CCGTCTCCCG TGCGCGATAC CCATGTTTAC1051 CCCTCTTTGG ATGTGCGCGG CATCATGCAG AAATCGTCCA ACGTCGGCAC 1101AAGCAAACTG TCTGCGCGTT TCGGTGCCGA AGAAATGTAT GACTTCTATC 1151 ATGAGTTGGGCATCGGTGTG CGTATGCACT CGGGCTTTCC GGGCGAAACT 1201 GCAGGTTTGT TGAGAAATTGGCGCAGGTGG CGGCCTATCG AACAGGCGAC 1251 GATGTCTTTC GGTTACGGCC TGCAATTGAGCCTGCTGCAA TTGGCGCGCG 1301 CCTATACCGC ACTGACGCAC GACGGCGTTT TACTGCCGGTCAGCTTTGAA 1351 AAACAGGCGG TTGCGCCGCA AGGCAAACGC ATATTCAAAG AATCGACCGC1401 GCGCGAGGTA CGCAATCTGA TGGTTTCCGT AACCGAGCCG GGCGGCACCG 1451GTACGGCGGG TGCGGTGGAC GGTTTCGATG TCGGCGCGAA AACCGGCACG 1501 GCGCGCAAGTTCGTCAACGG GCGTTATGCC GACAACAAAC ACATCGCTAC 1551 CTTTATCGGT TTTGCCCCCGCCAAAAATCC CCGTGTGATT GTGGCGGTAA 1601 CCATTGACGA ACCGACTGCC CACGGTTATTACGGCGGCGT AGTGGCAGGG 1651 CCGCCCTTCA AAAAAATTAT GGGCGGCAGC CTGAACATCTTGGGCATTTC 1701 CCCGACCAAG CCACTGACCG CCGCAGCCGT CAAAACACCG TCTTAAThis corresponds to the amino acid sequence <SEQ ID 2692; ORF 793.a>:

a793.pep 1 MLIKSEYKPR MLPKEEQVKK PMTSNGRISF VLMAIAVLFA GLIARGLYLQ 51TVTYNFLKEQ GDNRIVRTQT LPATRGTVSD RNGAVLALSA PTESLFAVPK 101 EMKEMPSAAQLERLSELVDV PVDVLRNKLE QKGKSFIWIK RQLDPKVAEE 151 VKALGLENFV FEKELKRHYPMGNLFAHVIG FTDIDGKGQE GLELSLEDSL 201 HGEDGAEVVL RDRQGNIVDS LDSPRNKAPKNGKDIILSLD QRIQTLAYEE 251 LNKAVEYHQA KAGTVVVLDA RTGEILALAN TPAYDPNRPGRADSEQRRNR 301 AVTDMIEPGS AIKPFVIAKA LDAGKTDLNE RLNTQPYKIG PSPVRDTHVY351 PSLDVRGIMQ KSSNVGTSKL SARFGAEEMY DFYHELGIGV RMHSGFPGET 401AGLLRNWRRW RPIEQATMSF GYGLQLSLLQ LARAYTALTH DGVLLPVSFE 451 KQAVAPQGKRIFKESTAREV RNLMVSVTEP GGTGTAGAVD GFDVGAKTGT 501 ARKFVNGRYA DNKHIATFIGFAPAKNPRVI VAVTIDEPTA HGYYGGVVAG 551 PPFKKIMGGS LNILGISPTK PLTAAAVKTP S*a793/m793 100.0% identity in 581 aa overlap        10        20        30        40        50        60 a793.pepMLIKSEYKPRMLPKEEQVKKPMTSNGRISFVLMAIAVLFAGLIARGLYLQTVTYNFLKEQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m793MLIKSEYKPRMLPKEEQVKKPMTSNGRISFVLMAIAVLFAGLIARGLYLQTVTYNFLKEQ        10        20        30        40        50        60        70        80        90       100       110       120 a793.pepGDNRIVRTQLLPATRGTVSDRNGAVLALSAPTESLFAVPKEMKEMPSAAQLERLSELVDV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m793GDNRIVRTQLLPATRGTVSDRNGAVLALSAPTESLFAVPKEMKEMPSAAQLERLSELVDV        70        80        90       100       110       120       130       140       150       160       170       180 a793.pepPVDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m793PVDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIG       130       140       150       160       170       180       190       200       210       220       230       240 a793.pepFTDIDGKGQEGLELSLEDSLHGEDGAEVVLRDRQGNIVDSLDSPRNKAPKNGKDIILSLD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m793FTDIDGKGQEGLELSLEDSLHGEDGAEVVLRDRQGNIVDSLDSPRNKAPKNGKDIILSLD       190       200       210       220       230       240       250       260       270       280       290       300 a793.pepQRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPAYDPNRPGRADSEQRRNR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m793QRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPAYDPNRPGRADSEQRRNR       250       260       270       280       290       300       310       320       330       340       350       360 a793.pepAVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDTHVYPSLDVRGIMQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m793AVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDTHVYPSLDVRGIMQ       310       320       330       340       350       360       370       380       390       400       410       420 a793.pepKSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMSF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m793KSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMSF       370       380       390       400       410       420       430       440       450       460       470       480 a793.pepGYGLQLSLLQLARAYTALTHDGVLLPVSFEKQAVAPQGKRIFKESTAREVRNLMVSVTEP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m793GYGLQLSLLQLARAYTALTHDGVLLPVSFEKQAVAPQGKRIFKESTAREVRNLMVSVTEP       430       440       450       460       470       480       490       500       510       520       530       540 a793.pepGGTGTAGAVDGFDVGAKTGTARKFVNGRYADNKHIATFIGFAPAKNPRVIVAVTIDEPTA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m793GGTGTAGAVDGFDVGAKTGTARKFVNGRYADNKHIATFIGFAPAKNPRVIVAVTIDEPTA       490       500       510       520       530       540       550       560       570       580 a793.pepHGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPSX|||||||||||||||||||||||||||||||||||||||||| m793HGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPSX       550       560       570       580The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2693>:

g794.seq 1 gtgcgtttca ATCATTTCAT AATGGTAACG ATTATTATAT ATGTGATTTC 51CCCTGCAAAC AAGCCGGTCC GCCGCCCCGG CGTTCCCACT TATCCGGCTT 101 TGCCTTATAATTGCTTTTTT TATGTAACAG ATTCACCTAT GAATTTCCCC 151 AAAACAGCGG CCTCCCTGCTGCTGCTTCTC GCCTCCCTCG CCGCACACGC 201 GCTCGATACC GGCCGCATTC CGCAAAACGAAATCGCTGTA TATGTCCAAG 251 AGCTTGACAG CGGAAAAGTC ATCATTGACC ACCGTGCCGGCATACCCGTC 301 AATCCCGCGT CCACGATGAA GCTCGTTACC GCGTTTGCCG CCTTCAAAAC351 CTTCGGCAGC AATTACCGCT GGGCGACCGA GTTTAAAAGC AACGGTACGG 401TAAACGACGG CACGCTTGAC GGAAACCTGT ATTGGGCGGG CAGCGGCGAC 451 CCCGTTTTCAATCAGGAAAA CCTGCTTGCC GTCCAACGCC AGTTGCGCGA 501 CAAAGGCATC CGCAATATCACGGGGCGCCT GATGCTCGAC CACAGCCTGT 551 GGGGCGAAGT CGGCAGTCCC GACCATTTTGAAGCCGACAG CGGTTCGCCG 601 TTTATGACGC CCCCAAATCC GACTATGCTG TCTGCCGGTATGGTTATGGT 651 GCGCGCCGAA CGCAATGCCG CCGGCAGTAC CGACATCCTC ACCGATCCGC701 CTTTGCCGCA TATTTTTGCC CAAAACAACT TGAAAATTAC CGCCTCCCAA 751GCTGCCTGCC CTTCGGTCAA AAAACTGATG CGCGCATCTT TTTCGGGCAA 801 TACGCTGAAATTGCGCGGCA ATATTCCCGA AAGCTGTTTG GGCAAGCCTG 851 TCGGTGTCCG GATGTTCGCGCTTGACGAAC TGATCCGCCA AAGTTTTACC 901 AACCGCTGGC TGCTCGGCGG CGGACGGATTTCAGACGGCA TCGGCATAGC 951 CGACACACCG GAAGGCGCGC AGACGCTTGC CGTTGCACACTCCAAACCGA 1001 TGAAGGAAAT TTTGACGGAC ATGAACAAGC GTTCGGACAA TCTGATTGCG1051 CGTTCCGTCT TCCTCAAACT CGGCGGCGAC GGCAAACTGC CCGCCGTTTC 1101CGAACAGGCG GCGTCTGCCG TCCGGCGAGA ACTTGCCGTA TCGGGCATCG 1151 ATGTTGCGGATTTGGTTTTG GAAAACGGTT CGGGTCTGTC CAGAAAAGAA 1201 AGGGTAACGG CGAGAATGATGGCGCAAATG TTGGAAACGG CTTATTTCAG 1251 CCCGTTTGCA CAAGATTTCA TCGACACGCTGCCCATCGCC GGCACAGACG 1301 GGACTTTACG CAACCGCTTC AAACAAAGCG GCGGGCTGTTGCGCTTAAAA 1351 ACCGGCACGC TCAACAATGT CCGCGCCCTT GCAGGTTATT GGCTGGGCGA1401 CAAACCGATG GCGGTGGTCG TCATCATCAA CAGCGGCCGC GCCGTTTCCC 1451TGCTGCCCGA CTTGGACAAC TTCGTTGCCA AAAACATCAT CTCCGGCGGC 1501 GACGGCTGGCTGGATGCGAA ACTGATGTGC AAAGAACGCC GCGCCTGAThis corresponds to the amino acid sequence <SEQ ID 2694; ORF 794.ng>:

g794.pep 1 VRFNHFIMVT IIIYVISPAN KPVRRPGVPT YPALPYNCFF YVTDSPMNFP 51KTAASLLLLL ASLAAHALDT GRIPQNEIAV YVQELDSGKV IIDHRAGIPV 101 NPASTMKLVTAFAAFKTFGS NYRWATEFKS NGTVNDGTLD GNLYWAGSGD 151 PVFNQENLLA VQRQLRDKGIRNITGRLMLD HSLWGEVGSP DHFEADSGSP 201 FMTPPNPTML SAGMVMVRAE RNAAGSTDILTDPPLPHIFA QNNLKITASQ 251 AACPSVKKLM RASFSGNTLK LRGNIPESCL GKPVGVRMFALDELIRQSFT 301 NRWLLGGGRI SDGIGIADTP EGAQTLAVAH SKPMKEILTD MNKRSDNLIA351 RSVFLKLGGD GKLPAVSEQA ASAVRRELAV SGIDVADLVL ENGSGLSRKE 401RVTARMMAQM LETAYFSPFA QDFIDTLPIA GTDGTLRNRF KQSGGLLRLK 451 TGTLNNVRALAGYWLGDKPM AVVVIINSGR AVSLLPDLDN FVAKNIISGG 501 DGWLDAKLMC KERRA*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2695>:

m794.seq 1 GTGCGTCTCA ATCATTTCAT AATGATAGCG ATTATTATAT ATGTGATTTC 51CCCTGCAAAC AAGCCGGCCC GCCGCCACAG CGTTCCCACT TATCCGGCTT 101 TGCCTTATAATTGCTTTTTT TATGTAACAG ATTTACCTAT GAATTTCCCC 151 AAAACAGCGG CCTCCCTGCTGCTGCTTCTC GCCTCCCTCG CCGCACACGC 201 GCTCGATACC GGCCGCATTC CGCAAAACGAAATCGCCGTA TATGTCCAAG 251 AGCTTGACAG CGGAAAAGTC ATCATTGACC ACCGCTCGGATGTCCCCGTC 301 AACCCCGCCT CCACAATGAA ACTCGTTACC GCGTTTGCCG CCTTCAAAAC351 CTTCGGCAGC AATTACCGCT GGGCGACCGA GTTTAAAAGC AACGGTACGG 401TAAACGACGG CACGCTTGAC GGAAACCTAT ATTGGGCGGG CAGCGGCGAC 451 CCCGTTTTCAATCAGGAAAA CCTGCTTGAT GCTCAAAAAC AGTTGCGCGA 501 ACAAGGCATA CTCAATATCACGGGACACCT GATGCTCGAC CACAGCCTGT 551 GGGGCGAAGT CGGCAGCCCC GACGATTTCGAAGCCGACAG CGGTTCGCCG 601 TTTATGACGC CCCCCAATCC AACTATGCTG TCTGCCGGTATGGTTATGGT 651 GCGCGCCGAA CGCAATGCCG CCGGCAGTAC CGACATCCTC ACCGATCCGC701 CTTTGCCGCA TATTTTCGCC CAAAACAACT TGAAAATTAC CGCCTCCCAA 751GCTGCCTGCC CTTCGATCAA AAAACTGATG CGTGCATCTT TTTCGGACAA 801 TACGCTGAAATTGCGCGGCA ATATTCCCGA GAGCTGTTTG GGCAAGCCTG 851 TCGGTGTCCG GATGTTCGCGCTTGACGAAC TGATCCGGCA AAGTTTTACC 901 AACCACTGGC TGCTCGGCGG CGGACGGATTTCAGACGGTA TCGGCATAGC 951 CGACACGCCG GAAGGCGCGC AGACACTTGC CGTTGCACACGCCAAACCGA 1001 TGAAAGAAAT TTTGACGGAC ATGAACAAGC GTTCGGACAA TCTAATTGCG1051 CGTTCCGTCT TCCTCAAACT CGGCGGCGAC GGCAAACTGC CCGCCGTTTC 1101CGAACAGGCG GCGTCTGCCG TCCGGCGCGA ACTTGCCGTA TCGGGCATCG 1151 ATGTTGCGGATTTGGTTTTG GAAAACGGTT CGGGCCTGTC CAGAAAAGAA 1201 AGGGTAACGG CGAGAATGATGGCGCAAATG TTGGAAACGG CTTATTTCAG 1251 CCCGTTTGCA CAAGATTTCA TCGACACGCTACCCATCGCC GGCACAGACG 1301 GAACTTTACG CAACCGCTTC AAACAAAGCG GCGGGCTGTTGCGCTTAAAA 1351 ACCGGCACGC TCAACAATGT CCGCGCCCTT GCAGGTTATT GGCTGGGCGA1401 CAAACCGATG GCGGTGGTCG TCATCATCAA CAGCGGCCGC GCCGTTTCCC 1451TGCTGCCAGA CTTGGACAAC TTCGTTGCCA ACAACATCAT CTCCGGCGGC 1501 GATGGCTGGCTGGATGCGAA ACTGATGTGC AAAGAACGCC GAGCCTGAThis corresponds to the amino acid sequence <SEQ ID 2696; ORF 794>:

m794.pep 1 VRLNHFIMIA IIIYVISPAN KPARRHSVPT YPALPYNCFF YVTDLPMNFP 51KTAASLLLLL ASLAAHALDT GRIPQNEIAV YVQELDSGKV IIDHRSDVPV 101 NPASTMKLVTAFAAFKTFGS NYRWATEFKS NGTVNDGTLD GNLYWAGSGD 151 PVFNQENLLD AQKQLREQGILNITGHLMLD HSLWGEVGSP DDFEADSGSP 201 FMTPPNPTML SAGMVMVRAE RNAAGSTDILTDPPLPHIFA QNNLKITASQ 251 AACPSIKKLM RASFSDNTLK LRGNIPESCL GKPVGVRMFALDELIRQSFT 301 NHWLLGGGRI SDGIGIADTP EGAQTLAVAH AKPMKEILTD MNKRSDNLIA351 RSVFLKLGGD GKLPAVSEQA ASAVRRELAV SGIDVADLVL ENGSGLSRKE 401RVTARMMAQM LETAYFSPFA QDFIDTLPIA GTDGTLRNRF KQSGGLLRLK 451 TGTLNNVRALAGYWLGDKPM AVVVIINSGR AVSLLPDLDN FVANNIISGG 501 DGWLDAKLMC KERRA*g794/m794 95.5% identity in 515 aa overlap        10        20        30        40        50        60 g794.pepVRFNHFIMVTIIIYVISPANKPVRRPGVPTYPALPYNCFFYVTDSPMNFPKTAASLLLLL||:|||||::||||||||||||:|| :||||||||||||||||| ||||||||||||||| m794VRLNHFIMIAIIIYVISPANKPARRHSVPTYPALPYNCFFYVTDLPMNFPKTAASLLLLL        10        20        30        40        50        60        70        80        90       100       110       120 g794.pepASLAAHALDTGRIPQNEIAVYVQELDSGKVIIDHRAGIPVNPASTMKLVTAFAAFKLFGS|||||||||||||||||||||||||||||||||||: :|||||||||||||||||||||| m794ASLAAHALDTGRIPQNEIAVYVQELDSGKVIIDHRSDVPVNPASTMKLVTAFAAFKLFGS        70        80        90       100       110       120       130       140       150       160       170       180 g794.pepNYRWATEFKSNGTVNDGTLDGNLYWAGSGDPVFNQENLLAVQRQLRDKGIRNITGRLMLD||||||||||||||||||||||||||||||||||||||| :|:|||::|| ||||:|||| m794NYRWATEFKSNGTVNDGTLDGNLYWAGSGDPVFNQENLLDAQKQLREQGILNITGHLMLD       130       140       150       160       170       180       190       200       210       220       230       240 g794.pepHSLWGEVGSPDHFEADSGSPFMTPPNPTMLSAGMVMVRAERNAAGSTDILTDPPLPHIFA||||||||||| |||||||||||||||||||||||||||||||||||||||||||||||| m794HSLWGEVGSPDDFEADSGSPFMTPPNPTMLSAGMVMVRAERNAAGSTDILTDPPLPHIFA       190       200       210       220       230       240       250       260       270       280       290       300 g794.pepQNNLKITASQAACPSVKKLMRASFSGNTLKLRGNIPESCLGKPVGVRMFALDELIRQSFT|||||||||||||||:||||||||| |||||||||||||||||||||||||||||||||| m794QNNLKITASQAACPSIKKLMRASFSDNTLKLRGNIPESCLGKPVGVRMFALDELIRQSFT       250       260       270       280       290       300       310       320       330       340       350       360 g794.pepNRWLLGGGRISDGIGIADTPEGAQTLAVAHSKPMKEILTDMNKRSDNLIARSVFLKLGGD|:||||||||||||||||||||||||||||:||||||||||||||||||||||||||||| m794NHWLLGGGRISDGIGIADTPEGAQTLAVAHAKPMKEILTDMNKRSDNLIARSVFLKLGGD       250       260       270       280       290       300       370       380       390       400       410       420 g794.pepGKLPAVSEQAASAVRRELAVSGIDVADLVLENGSGLSRKERVTARMMAQMLETAYFSPFA||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||||| m794GKLPAVSEQAASAVRRELAVSGIDVADLVLENGSGLSRKERVTARMMAQMLETAYFSPFA       370       380       390       400       410       420       430       440       450       460       470       480 g794.pepQDFIDTLPIAGTDGTLRNRFKQSGGLLRLKTGLLNNVRALAGYWLGDKPMAVVVIINSGR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m794QDFIDTLPIAGTDGTLRNRFKQSGGLLRLKTGLLNNVRALAGYWLGDKPMAVVVIINSGR       430       440       450       460       470       480       490       500       510 g794.pepAVSLLPDLDNFVAKNIISGGDGWLDAKLMCKERRAX|||||||||||||:|||||||||||||||||||||| m794AVSLLPDLDNFVANNIISGGDGWLDAKLMCKERRAX        490       500       510The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2697>:

a794.seq 1 GTGCGTCTCA ATCATTTCAT AATGATAGCG ATTATTATAT ATGTGATTTC 51CCCTGCAAAC AAGCCGGCCC GCCGCCACAG CGTTCCCACT TATCCGGCTT 101 TGCCTTATAATTGCTTTTTT TATGTAACAG ATTTACCTAT GAATTTCCCC 151 AAAACAGCGG CCTCCCTGCTGCTGCTTCTC GCCTCCCTCG CCGCACACGC 201 GCTCGATACA GGTCGCATTC CGCAAAACGAAATCGCCGTA TATGTCCAAG 251 AGCTTGACAG CGGAAAAGTC ATCATTGACC ACCGCTCGGATGTCCCCGTC 301 AACCCCGCCT CCACAATGAA ACTCGTTACC GCGTTTGCCG CCTTCAAAAC351 CTTCGGCAGC AATTACCGCT GGGCGACCGA GTTTAAAAGC AACGGTACGG 401TAAACGACGG CACGCTTGAC GGAAACCTGT ATTGGGCGGG CAGCGGCGAC 451 CCCGTTTTCAATCAGGAAAA CCTGCTTGCC GTCCAACGCC AGTTGCGCGA 501 ACAAGGCATA CGCAATATCACGGGACACCT GATGCTCGAC CACAGCCTGT 551 GGGGCGAAGT CGGCAGCCCC GACGATTTCGAAGCCGACAG CGGTTCGCCG 601 TTTATGACGC CCCCCAATCC AACTATGCTG TCTGCCGGTATGGTTATGGT 651 GCGCGCCGAA CGCAATGCCG CCGACAGTAC CGACATCCTC ACCGATCCGC701 CTTTGCCGCA TATTTTCGCC CAAAACAACT TGAAAATTAC CGCCTCCCAA 751GCTGCCTGCC CTTCGATCAA AAAACTGATG CGTGCATCTT TTTCGGACAA 801 TACGCTGAAATTGCGCGGCA ATATTCCCGA GAGCTGTTTG GGCAAGCCTG 851 TCGGTGTCCG GATGTTCGCGCTTGACGAAC TGATCCGGCA AAGTTTTACC 901 AACCACTGGC TGCTCGGCGG CGGACGGATTTCAGACGGCA TCGGCATATC 951 CGACACGCCG GAAGGCGCGC AGACGCTTGC CGTTGCACACTCAAAGCCGA 1001 TGAAGGAAAT TTTGACGGAC ATGAACAAGC GTTCGGACAA TCTAATTGCG1051 CGTTCCGTCT TCCTCAAACT CGGCGGCGAC GGCAAACTGC CCGCCGTTTC 1101CGAACAGGCA GCGTCTGCCG TCCGGCGTGA ACTTGCCGTG TCGGGCATCG 1151 ATGTTGCGGATTTGGTTTTG GAAAACGGTT CAGGTCTGTC CAGAAAAGAA 1201 AGGGTAACGG CGAGAATGATGGCGCAAATG TTGGAAACGG CTTATTTCAG 1251 CCCGTTTGCA CAAGATTTCA TCGATACGCTGCCCATCGCC GGCACAGACG 1301 GGACTTTACG CAACCGCTTC AAACAAAGCG GCGGGCTGTTGCGCTTAAAA 1351 ACCGGCACGC TCAACAATGT CCGCGCCCTT GCAGGTTATT GGCTGGGCGA1401 CAAACCGATG GCGGTGGTCG TCATCATCAA CAGCGGCCGC GCCGTTTCCC 1451TGCTGCCCGA CTTGGACAAC TTCGTTGCCA ACAACATCAT CTCCGGCGGC 1501 GATGGCTGGCTGGATGCGAA ACTGATGTGC AAAGAACGCC GAGCCTGAThis corresponds to the amino acid sequence <SEQ ID 2698; ORF 794.a>:

a794.pep 1 VRLNHFIMIA IIIYVISPAN KPARRHSVPT YPALPYNCFF YVTDLPMNFP 51KTAASLLLLL ASLAAHALDT GRIPQNEIAV YVQELDSGKV IIDHRSDVPV 101 NPASTMKLVTAFAAFKTFGS NYRWATEFKS NGTVNDGTLD GNLYWAGSGD 151 PVFNQENLLA VQRQLREQGIRNITGHLMLD HSLWGEVGSP DDFEADSGSP 201 FMTPPNPTML SAGMVMVRAE RNAADSTDILTDPPLPHIFA QNNLKITASQ 251 AACPSIKKLM RASFSDNTLK LRGNIPESCL GKPVGVRMFALDELIRQSFT 301 NHWLLGGGRI SDGIGISDTP EGAQTLAVAH SKPMKEILTD MNKRSDNLIA351 RSVFLKLGGD GKLPAVSEQA ASAVRRELAV SGIDVADLVL ENGSGLSRKE 401RVTARMMAQM LETAYFSPFA QDFIDTLPIA GTDGTLRNRF KQSGGLLRLK 451 TGTLNNVRALAGYWLGDKPM AVVVIINSGR AVSLLPDLDN FVANNIISGG 501 DGWLDAKLMC KERRA*a794/m794 98.6% identity in 515 aa overlap        10        20        30        40        50        60 a794.pepVRLNHFIMIAIIIYVISPANKPARRHSVPTYPALPYNCFFYVTDLPMNFPKTAASLLLLL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m794VRLNHFIMIAIIIYVISPANKPARRHSVPTYPALPYNCFFYVTDLPMNFPKTAASLLLLL        10        20        30        40        50        60        70        80        90       100       110       120 a794.pepASLAAHALDTGRIPQNEIAVYVQELDSGKVIIDHRSDVPVNPASTMKLVTAFAAFKLFGS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m794ASLAAHALDTGRIPQNEIAVYVQELDSGKVIIDHRSDVPVNPASTMKLVTAFAAFKLFGS        70        80        90       100       110       120       130       140       150       160       170       180 a794.pepNYRWATEFKSNGTVNDGTLDGNLYWAGSGDPVFNQENLLAVQRQLREQGIRNITGHLMLD||||||||||||||||||||||||||||||||||||||| :|:||||||| ||||||||| m794NYRWATEFKSNGTVNDGTLDGNLYWAGSGDPVFNQENLLDAQKQLREQGILNITGHLMLD       130       140       150       160       170       180       190       200       210       220       230       240 a794.pepHSLWGEVGSPDDFEADSGSPFMTPPNPTMLSAGMVMVRAERNAADSTDILTDPPLPHIFA|||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||| m794HSLWGEVGSPDDFEADSGSPFMTPPNPTMLSAGMVMVRAERNAAGSTDILTDPPLPHIFA       190       200       210       220       230       240       250       260       270       280       290       300 a794.pepQNNLKITASQAACPSIKKLMRASFSDNTLKLRGNIPESCLGKPVGVRMFALDELIRQSFT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m794QNNLKITASQAACPSIKKLMRASFSDNTLKLRGNIPESCLGKPVGVRMFALDELIRQSFT       250       260       270       280       290       300       310       320       330       340       350       360 a794.pepNHWLLGGGRISDGIGISDTPEGAQTLAVAHSKPMKEILTDMNKRSDNLIARSVFLKLGGD||||||||||||||||:|||||||||||||:||||||||||||||||||||||||||||| m794NHWLLGGGRISDGIGIADTPEGAQTLAVAHAKPMKEILTDMNKRSDNLIARSVFLKLGGD       310       320       330       340       350       360       370       380       390       400       410       420 a794.pepGKLPAVSEQAASAVRRELAVSGIDVADLVLENGSGLSRKERVTARMMAQMLETAYFSPFA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m794GKLPAVSEQAASAVRRELAVSGIDVADLVLENGSGLSRKERVTARMMAQMLETAYFSPFA       370       380       390       400       410       420       430       440       450       460       470       480 a794.pepQDFIDTLPIAGTDGTLRNRFKQSGGLLRLKTGLLNNVRALAGYWLGDKPMAVVVIINSGR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m794QDFIDTLPIAGTDGTLRNRFKQSGGLLRLKTGLLNNVRALAGYWLGDKPMAVVVIINSGR       430       440       450       460       470       480       490       500       510 a794.pepAVSLLPDLDNFVANNIISGGDGWLDAKLMCKERRAX|||||||||||||||||||||||||||||||||||| m794AVSLLPDLDNFVANNIISGGDGWLDAKLMCKERRAX        490       500       510The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2699>:

g900.seq 1 ATGccgTCTG AAATGCCGTC TGAAACGTGG CAGGCGGAGG TTCGGACGGC 51ATTGGGTTTA TTTCAACGGG CGGATGCCGA CCGCATCGCG TACTTTATCC 101 AACAATTCGCGCGCTTCTTT GCGCGCTTTT TGCGCGcctg cctGCAAAAT 151 CTCTTCGATT TGCGAAGGATTAGAGGTCAA TGCGTTGTAG CGTTCGCGCA 201 GTTCTGCCAA TTCGGCGTTG ATTTTCGCCGCCGAAAGTTT TTTCGCCTCG 251 CCCCAAGCCA AGCCGTCGGC AAGCATTTGC GTAAATTCCGCCGTTTCAGA 301 CGGCGTGGAG AAGGCTTTAT AGATTTCAAA CAAAGGGCTT TCGTCGGGCT351 GTTTCGGCTC GCCCGGCTCT TTCATGTTGG TAATGATTTT GTTGACCGAT 401TTTTGGGTTT TTTTGTCGTT TTCCCAAAGC GGAATGGTAT TGCCGTAGGA 451 TTTGGACATTTTGCGTCCGT CCAAACCGAC CAAGAGTTCG ACGTTTTCGT 501 CGATTTTCAC TTCGGGCaggGTGaagagtt cTTGGAaacc gtgggtgaag 551 cggccggcAa tgtcgcgcgc cATTTcgacgtgttgGATTT GGTCGCGCCC 601 GACGGGGACT TCGTTGGCGT TGAACATCAA AATGTCGGCAGTCATCAGAA 651 TCGGATAACT GAACAAACCC ATTTCCACAC CGAAATCGGG GTCTTCCTGC701 CCGTTTTCCG CATTGGCTTG AACGGCGGCT TTGTAGGCGT GGGCGCGGTT 751CATCAAACCC TTGGCGGTGA TGCAGGTCAG AATCCAGTTC AACTCCATCA 801 CTTCGGGAATGTCGCTTTGG CGGTAGAAGG TGGTGCGCTC GGGGTCGAGT 851 CCGCAGGCAA GCCAAGTGGCGGCAACGGCt tgGGTGGATT GGTGAATCAT 901 CTCCTGCTCG TGGCATTTGA TGATGCCGTGGTAATCGGCG AGGAAGAGGA 951 AGGATTCGGT ATCGGGGTTT TGCGCCGCGC GGACGGCGGGGCGGATGGCG 1001 CCGACGTAGT TGCCCAGATG CGGGGTGCCG GTGGTGGTTA CGCCGGTCAG1051 AACTCGTTTT TTGCTCATAA AAATGTCCTT ACGGCAGCAA TGCCGTCTGA 1101AAGGGAAAa. gatgcgCCGA TTATACCCGA TTTGCCACAT ACATCCAGCC 1151 GacaACagaCTTTTCCATAT TAAThis corresponds to the amino acid sequence <SEQ ID 2700; ORF 900.ng:

g900.pep 1 MPSEMPSETW QAEVRTALGL FQRADADRIA YFIQQFARFF ARFLRACLQN 51LFDLRRIRGQ CVVAFAQFCQ FGVDFRRRKF FRLAPSQAVG KHLRKFRRFR 101 RRGEGFIDFKQRAFVGLFRL ARLFHVGNDF VDRFLGFFVV FPKRNGIAVG 151 FGHFASVQTD QEFDVFVDFHFGQGEEFLET VGEAAGNVAR HFDVLDLVAP 201 DGDFVGVEHQ NVGSHQNRIT EQTHFHTEIGVFLPVFRIGL NGGFVGVGAV 251 HQTLGGDAGQ NPVQLHHFGN VALAVEGGAL GVESAGKPSGGNGLGGLVNH 301 LLLVAFDDAV VIGEEEEGFG IGVLRRADGG ADGADVVAQM RGAGGGYAGQ351 NSFFAHKNVL TAAMPSEREK DAPIIPDLPH TSSRQQTFPY *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2701>:

m900.seq 1 ATGCCGTCTG AAACGCGGCA GGCGGAGGTT CGGACGGCAT CGGGTTCATT 51TCAACGGGCG GATGcCGACC GCATCgG.TA CTTTGTCCAA TAATTCGCGT 101 GCTTCTTTACGCGCTTTCGC CGCGCCTGCC TGCAAAATCT CTTCGATTTG 151 CGAAGGGTCG GCGGTCAGCTCGTTGTAGCG TTCGCGCGGT TCGGCGAGTT 201 CGGCGTTGAT TTTCGCCGCC AAAAGTTTTTTGGCTTCACC CCACGCCAAG 251 CCGTCGGCAA GCATTTTCGT AAATTCCACC GTTTCAGACGGCGTGGAGAA 301 GGCTTTGTAG ATTTCAAACA ATGGGCTTTC GTCGGGCTGT TTCGGCTCGC351 CCGGCTCTTT CATATTGGTG ATGATTTTGT TGACCGATTT TTGGGTTTTT 401tTGTCGTTTT CCCAAAGCGG AATGGTGTTG CCGTAGGATT TGGACATTTT 451 GCGTCCGTCCAAACCGACCA AGAGTTCGAC GTTTTCATCG ATTTTCACTT 501 CGGGCAGGGT GAAGAGTTCCCGGAAGCGGT GGTTGAAGCG GCCGGCGATG 551 TCGCGCGCCA TTTCGACGTG TTGGATTTGGTCGCGCCCGA CgGGCaCTTC 601 GTTGGCGTTG AACATCAGAA TATCGGCAGT CATCAGAATCGGATAACTGA 651 ACAAACCCAT TTCCACACCG AAATCAGGGT CTTCCTGCCC GTTTTCTGCA701 TTTGCCTGCA CGGCGGCTTT GTAGGCATGG GCGCGGTTCA TCAAACCCTT 751GGCAGTGATG CAGGTCAGAA TCCAGTTCAA TTCCATCACT TCgGGAGTGT 801 CGCTTTGGCGGTAGAAGGTG GTGCGCTCGG GGTCGAGTCC GCAgGCAAGC 851 CAAGTGGCGG CAACGGCTTGGGTGGATTGG TGAATCATCT CCGGCTCGTG 901 GCATTTGATG ATACCGTGGT AATCGGCGAGGAAGAGGAAG GATTCGGTAT 951 CGAGGTTTTG CGCCGCGCGG ACGGCGGGGC GGATGGCGCCGACGTAGTTG 1001 CCCAGATGCG GGATGCCGGT GGTGGTTACG CCGGTCAGAA CTCGTTTTTT1051 GCTCATAAAA ATGTCCTTGC GGCATCAATG CCGTCTGAAA GGGAAAAAGA 1101TGTGCCGATT ATACCCGATT TGCCACCTAC ATCCAGCCGA CAACAGACTT 1151 TTCCATATTA AThis corresponds to the amino acid sequence <SEQ ID 2702; ORF 900>:

m900.pep 1 MPSETRQAEV RTASGSFQRA DADRIXYFVQ *FACFFTRFR RACLQNLFDL 51RRVGGQLVVA FARFGEFGVD FRRQKFFGFT PRQAVGKHFR KFHRFRRRGE 101 GFVDFKQWAFVGLFRLARLF HIGDDFVDRF LGFFVVFPKR NGVAVGFGHF 151 ASVQTDQEFD VFIDFHFGQGEEFPEAVVEA AGDVARHFDV LDLVAPDGHF 201 VGVEHQNIGS HQNRITEQTH FHTEIRVFLPVFCICLHGGF VGMGAVHQTL 251 GSDAGQNPVQ FHHFGSVALA VEGGALGVES AGKPSGGNGLGGLVNHLRLV 301 AFDDTVVIGE EEEGFGIEVL RRADGGADGA DVVAQMRDAG GGYAGQNSFF351 AHKNVLAASM PSEREKDVPI IPDLPPTSSR QQTFPY*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 900 shows 87.0% identity over a 386 aa overlap with a predicted ORF(ORF 900.ng) from N. gonorrhoeae:

m900/g900             10        20        30        40        50m900.pep     MPSETRQAEVRTASGSFQRADADRIGYFVQXFACFFTRFRRACLQNLFDLRRVGGQ    ||||| ||||||| | |||||||||:||:| || ||:|| |||||||||||: || g900MPSEMPSETWQAEVRTALGLFQRADADRIAYFIQQFARFFARFLRACLQNLFDLRRIRGQ        10        20        30        40        50        60  60        70        80        90       100       110 m900.pepLVVAFARFGEFGVDFRRQKFFGFTPRQAVGKHFRKFHRFRRRGEGFVDFKQWAFVGLFRL |||||:| :|||||||:||| ::| ||||||:|||:|||||||||:|||| |||||||| g900CVVAFAQFCQFGVDFRRRKFFRLAPSQAVGKHLRKFRRFRRRGEGFIDFKQRAFVGLFRL        70        80        90       100       110       120 120       130       140       150       160       170 m900.pepARLFHIGDDFVDRFLGFFVVFPKRNGVAVGFGHFASVQTDQEFDVFIDFHFGQGEEFPEA|||||:|:||||||||||||||||||:|||||||||||||||||||:|||||||||| |: g900ARLFHVGNDFVDRFLGFFVVFPKRNGIAVGFGHFASVQTDQEFDVFVDFHFGQGEEFLET       130       140       150       160       170       180 180       190       200       210       220       230 m900.pepVVEAAGDVARHFDVLDLVAPDGHFVGVEHQNIGSHQNRITEQTHFHTEIRVFLPVFCICL| ||||:||||||||||||||| ||||||||:||||||||||||||||| |||||| | | g900VGEAAGNVARHFDVLDLVAPDGDFVGVEHQNVGSHQNRITEQTHFHTEIGVFLPVFRIGL       190       200       210       220       230       240 240       250       260       270       280       290 m900.pepHGGFVGMGAVHQTLGSDAGQNPVQFHHFGSVALAVEGGALGVESAGKPSGGNGLGGLVNH:|||||:||||||||:||||||||:||||:|||||||||||||||||||||||||||||| g900NGGFVGVGAVHQTLGGDAGQNPVQLHHFGNVALAVEGGALGVESAGKPSGGNGLGGLVNH       250       260       270       280       290       300 300       310       320       330       340       350 m900.pepLRLVAFDDTVVIGEEEEGFGIEVLRRADGGADGADVVAQMRDAGGGYAGQNSFFAHKNVL| ||||||:|||||||||||| ||||||||||||||||||| |||||||||||||||||| g900LLLVAFDDAVVIGEEEEGFGIGVLRRADGGADGADVVAQMRGAGGGYAGQNSFFAHKNVL       310       320       330       340       350       360 360       370       380 m900.pep AASMPSEREKDVPIIPDLPPTSSRQQTFPYX:|:||||||||:||||||| ||||||||||| g900 TAAMPSEREKDAPIIPDLPHTSSRQQTFPYX       370       380       390The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2703>:

a900.seq (partial) 1 GAGGTTCGGA CGGCATTGGG TTTATTTCAA CGGGCGGATACCGACCGCAT 51 CACGTACTTT GCCCAATAAT TCGCGTGCTT CTTTACGCGC TTTTTGCGCG 101CCTGCCTGCA AAATCTCTTC GATTTGCGAA GGGTCGGCGG TCAGCTCGTT 151 GTAGCGTTCGCGCGGTTCGG CGAGTTCGGC GTTGATTTTC GCCGCCAAAA 201 GTTTTTTTGC CTCGCCCCAAGCCAAGCCGT CGGCAAGCAT TTTCGTAAAT 251 TCTGCCGTTT CAGACGGCGT GGAGAAAGCTTTGTAGATTT CAAACAGAGG 301 GCTTTCGTCG GGCTTCTTCG GCTCGCCCGG CTCTTTCATATTGGTGATGA 351 TTTTGTTGAC CGATTTTTGG GTTTTTTTGT CGTTTTCCCA AAGCGGAATG401 GTGTTGCCGT AGGATTTGGA CATTTTGCGT CCGTCCAAAC CAACCAAGAG 451TTCGACGTTT TCGTCGATTT TCACTTCGGG CAGTGTGAAG AGTTCCCGGA 501 AGCGGTGGTTGAAGCGGCCG GCAATATCGC GTGCCATTTC AACGTGTTGG 551 ATTTGGTCGC GACCGACTGGAACTTCATGG GCATTGAACA TGAGAATGTC 601 GGCAGTCATG AGGATAGGGT AGCTGTACAAACCCATTTCC ACGCCGAAAT 651 CGGGGTCTTC CTGCCCGTTT TCCGCATTTG CCTGCACGGCGGCTTTGTAG 701 GCGTGGGCGC GGTTCATCAA ACCCTTGGCG GTGATGCAGG TCAGAATCCA751 GTTCAATTCC ATCACTTCGG GAATGTCGCT TTGACGGTAG AAGGTGGTGC 801GCTCGGGGTC GAGTCCGCAG GCAAGCCAAG TGGCGGCAAC GGCTTGGGTG 851 GATTGGTGAATCATCTCCGG CTCGTGGCAT TTGATGATAC CGTGGTAATC 901 GGCGAGGAAG AGGAAGGATTCGGTATCAGG GTTTTGCGCC GCGCGGACGG 951 CGGGGCGGAT AGCACCGACG TAGTTGCCCAGATGCGGGAT GCCGGTGGTG 1001 GTTACGCCGG TCAGAACTCG TTTTTTGCTC ATAAAAATGTCCTTGCGGCA 1051 TCAATGCCGT CTGAAAGGGA AAAAGATGCG CCGATTATAC CCGATTTGCC1101 ACCTACATCC AGCCGACAAC AGACTTTTCC ATATTAAThis corresponds to the amino acid sequence <SEQ ID 2704; ORF 900.a>:

a900.pep (partial) 1 EVRTALGLFQ RADTDRITYF AQ*FACFFTR FLRACLQNLFDLRRVGGQLV 51 VAFARFGEFG VDFRRQKFFC LAPSQAVGKH FRKFCRFRRR GESFVDFKQR 101AFVGLLRLAR LFHIGDDFVD RFLGFFVVFP KRNGVAVGFG HFASVQTNQE 151 FDVFVDFHFGQCEEFPEAVV EAAGNIACHF NVLDLVATDW NFMGIEHENV 201 GSHEDRVAVQTHFHAEIGVF LPVFRICLHG GFVGVGAVHQ TLGGDAGQNP 251 VQFHHFGNVA LTVEGGALGVESAGKPSGGN GLGGLVNHLR LVAFDDTVVI 301 GEEEEGFGIR VLRRADGGAD STDVVAQMRDAGGGYAGQNS FFAHKNVLAA 351 SMPSEREKDA PIIPDLPPTS SRQQTFPY* m900/a90088.4% identity in 378 aa overlap        10        20        30        40        50        60 m900.pepMPSETRQAEVRTASGSFQRADADRIXYFVQXFACFFTRFRRACLQNLFDLRRVGGQLVVA        ||||| | |||||:|||:||:|||||||||| |||||||||||||||||||| a900        EVRTALGLFQRADTDRITYFAQXFACFFTRFLRACLQNLFDLRRVGGQLVVA                10        20        30        40        50        70        80        90       100       110       120 m900.pepFARFGEFGVDFRRQKFFGFTPRQAVGKHFRKFHRFRRRGEGFVDFKQWAFVGLFRLARLF||||||||||||||||| ::| |||||||||| |||||||:|||||| |||||:|||||| a900FARFGEFGVDFRRQKFFCLAPSQAVGKHFRKFCRFRRRGESFVDFKQRAFVGLLRLARLF      60        70        80        90       100       110       130       140       150       160       170       180 m900.pepHIGDDFVDRFLGFFVVFPKRNGVAVGFGHFASVQTDQEFDVFIDFHFGQGEEFPEAVVEA|||||||||||||||||||||||||||||||||||:||||||:|||||| |||||||||| a900HIGDDFVDRFLGFFVVFPKRNGVAVGFGHFASVQTNQEFDVFVDFHFGQCEEFPEAVVEA     120       130       140       150       160       170       190       200       210       220       230       240 m900.pepAGDVARHFDVLDLVAPDGHFVGVEHQNIGSHQNRITEQTHFHTEIRVFLPVFCICLHGGF||::| ||:|||||| | :|:|:||:|:|||::|:: |||||:|| |||||| ||||||| a900AGNIACHFNVLDLVATDWNFMGIEHENVGSHEDRVAVQTHFHAEIGVFLPVFRICLHGGF     180       190       200       210       220       230       250       260       270       280       290       300 m900.pepVGMGAVHQTLGSDAGQNPVQFHHFGSVALAVEGGALGVESAGKPSGGNGLGGLVNHLRLV||:||||||||:|||||||||||||:|||:|||||||||||||||||||||||||||||| a900VGVGAVHQTLGGDAGQNPVQFHHFGNVALTVEGGALGVESAGKPSGGNGLGGLVNHLRLV     240       250       260       270       280       290       310       320       330       340       350       360 m900.pepAFDDTVVIGEEEEGFGIEVLRRADGGADGADVVAQMRDAGGGYAGQNSFFAHKNVLAASM|||||||||||||||||:||||||||||::|||||||||||||||||||||||||||||| a900AFDDTVVIGEEEEGFGIRVLRRADGGADSTDVVAQMRDAGGGYAGQNSFFAHKNVLAASM     300       310       320       330       340       350       370       380 m900.pep PSEREKDVPIIPDLPPTSSRQQTFPYX|||||||:||||||||||||||||||| a900 PSEREKDAPIIPDLPPTSSRQQTFPYX     360       370

g901.seq not found yet

g901.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2705>:

m901.seq 1 ATGCCCGATT TTTCGATGTC CAATTTGGCC GTTGCCTTTT CCATCACATT 51GGCTGCCGGT TTGTTTACCG TATTAkGyAG TGGCTTGGTG ATGTTTTCCA 101 AAACGCCCAATCCGCGTGTG TTGTCGTTTG GTTTGGCGTT TGCCGGCGGT 151 GCGATGGTAT ATGTTTCCCTGACGGAGATT TTCAGTAAGT CCAGCGAGGC 201 GTTCGCTGAA ATTTATGATA AAGACCACGCGTTTGCGGCG GCGACCATGG 251 CATTTTTGGC CGGGATGGGC GGCATTGCGC TGATTGACCGTCTGGTGCCG 301 AACCCGCATG AAACTTTAGA CGCGCAAGAC CCGTCGTTTC AAGAAAGCAA351 ACGCCGCCAT ATCGCGCGAG TCGGCATGAT GGCGGCGTTT GCGATTACTG 401CGCACAATTT CCCCGAAGGC TTGGCGACGT TTTTTGCCAC ATTGGAAAAT 451 CCAGCAGTCGGGATGCCTTT GGCCTTGGCG ATTGCCATCC ATAATATTCC 501 GGAGGGCATT TCCATCGCCGCGCCGGTTTA TTTTGCCACC CGCAGCCGTA 551 AGAAAACGGT GTGGGCGTGT CTGCTATCCGGCTTGGCCGA GCCGTTGGGG 601 GCGGCTTTGG GCTATTTGGT TTTGCAGCCG TTTTTGTCGCCTGCCGTGTT 651 TGGTTCGGTA TTCGGCGTGA TAGCCGGTGT GATGGTGTTT TTGGCGTTGG701 ACGAGCTGnt GCCGGCTGCC AAACGCTATT CAGACGGCCA TGAAACCGTT 751TACGGCCTGA CAACGGGTAT GGCGGTGATT GCCGTCAGCC TGGTATTGTT 801 CCATTTTTAAThis corresponds to the amino acid sequence <SEQ ID 2706; ORF 901>:

m901.pep 1 MPDFSMSNLA VAFSITLAAG LFTVLXSGLV MFSKTPNPRV LSFGLAFAGG 51AMVYVSLTEI FSKSSEAFAE IYDKDHAFAA ATMAFLAGMG GIALIDRLVP 101 NPHETLDAQDPSFQESKRRH IARVGMMAAF AITAHNFPEG LATFFATLEN 151 PAVGMPLALA IAIHNIPEGISIAAPVYFAT RSRKKTVWAC LLSGLAEPLG 201 AALGYLVLQP FLSPAVFGSV FGVIAGVMVFLALDELXPAA KRYSDGHETV 251 YGLTTGMAVI AVSLVLFHF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2707>:

a901.seq 1 ATGCCCGATT TTTCGATGTC CAATTTGGCC GTTGCCTTTT CCATTACGTT 51GGCTGCCGGT TTGTTTACCG TATTAGGCAG CGGCTTGGTG ATGTTTTCCA 101 AAACGCCCAATCCGCGCGTG TTGTCGTTTG GTTTGGCATT TGCCGGCGGT 151 GCGATGGTGT ATGTTTCCCTGACGGAGATT TTCAGTAAGT CCAGCGAGGC 201 GTTCGCTGAA ATTTATGATA AAGACCACGCGTTTGCGGCG GCGACCATGG 251 CATTTTTGGC AGGGATGGGC GGCATTGCGC TGATTGACCGTCTGGTGCCG 301 AACCCGCATG AAACTTTAGA CGCGCAAGAC CCGTCGTTTC AAGAAAGCAA351 ACGCCGCCAT ATCGCGCGAG TCGGCATGAT GGCGGCGTTT GCGATTACTG 401CGCACAATTT CCCCGAAGGC TTGGCGACGT TTTTTGCCAC ATTGGAAAAT 451 CCAGCAGTCGGGATGCCTTT GGCCTTGGCG ATTGCCATCC ATAATATTCC 501 GGAGGGCATT TCCATCGCCGCGCCGGTTTA TTTTGCCACC CGCAGCCGTA 551 AGAAAACGGT GTGGGCGTGT CTGCTATCCGGCTTGGCCGA GCCGTTGGGG 601 GCGGCTTTGG GCTATTTGGT TTTGCAGCCG TTTTTGTCGCCTGCCGTGTT 651 TGGTTCGGTA TTCGGCGTGA TAGCCGGTGT GATGGTGTTT TTGGCGTTGG701 ACGAGCTGCT GCCGGCTGCC AAACGCTATT CAGACGGCCA TGAAACCGTT 751TACGGCCTGA CAATGGGCAT GGCGGTGATT GCCGTCAGCC TGGTATTGTT 801 CCATTTTTAAThis corresponds to the amino acid sequence <SEQ ID 2708; ORF 901.a>:

a901.pep 1 MPDFSMSNLA VAFSITLAAG LFTVLGSGLV MFSKTPNPRV LSFGLAFAGG 51AMVYVSLTEI FSKSSEAFAE IYDKDHAFAA ATMAFLAGMG GIALIDRLVP 101 NPHETLDAQDPSFQESKRRH IARVGMMAAF AITAHNFPEG LATFFATLEN 151 PAVGMPLALA IAIHNIPEGISIAAPVYFAT RSRKKTVWAC LLSGLAEPLG 201 AALGYLVLQPFLSPAVFGSV FGVIAGVMVF LALDELLPAA KRYSDGHETV 251 YGLTMGMAVI AVSLVLFHF*m901/a901 98.9% identity in 269 aa overlap        10        20        30        40        50        60 m901.pepMPDFSMSNLAVAFSITLAAGLFTVLXSGLVMFSKTPNPRVLSFGLAFAGGAMVYVSLTEI||||||||||||||||||||||||| |||||||||||||||||||||||||||||||||| a901MPDFSMSNLAVAFSITLAAGLFTVLGSGLVMFSKTPNPRVLSFGLAFAGGAMVYVSLTEI        10        20        30        40        50        60        70        80        90       100       110       120 m901.pepFSKSSEAFAEIYDKDHAFAAATMAFLAGMGGIALIDRLVPNPHETLDAQDPSFQESKRRH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a901FSKSSEAFAEIYDKDHAFAAATMAFLAGMGGIALIDRLVPNPHETLDAQDPSFQESKRRH        70        80        90       100       110       120       130       140       150       160       170       180 m901.pepIARVGMMAAFAITAHNFPEGLATFFATLENPAVGMPLALAIAIHNIPEGISIAAPVYFAT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a901IARVGMMAAFAITAHNFPEGLATFFATLENPAVGMPLALAIAIHNIPEGISIAAPVYFAT       130       140       150       160       170       180       190       200       210       220       230       240 m901.pepRSRKKTVWACLLSGLAEPLGAALGYLVLQPFLSPAVFGSVFGVIAGVMVFLALDELXPAA|||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||| a901RSRKKTVWACLLSGLAEPLGAALGYLVLQPFLSPAVFGSVFGVIAGVMVFLALDELLPAA       190       200       210       220       230       240       250       260       270 m901.pep KRYSDGHETVYGLTTGMAVIAVSLVLFHFX|||||||||||||| ||||||||||||||| a901 KRYSDGHETVYGLTMGMAVIAVSLVLFHFX       250       260       270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2709>:

g902.seq 1 ATGCCGTCCG AACCCGAACG GCGGCATGGC AATACTGCCC TACCCTTCCC 51GATAGCCGCA CGCCCAACGG TCGGTTTTTC CGGCAAGCCT TTCAAGATAA 101 CCGGCAAGTGTGTCGTATTG CGCCGCCGCA TTGTCCAAGC GGTTGATTTC 151 ACGCCGCGCC TGTTCGCCGTCGGGCATTTC GCCGATGTAC CAGCCTATGT 201 GTTTGCGTGC GATGCGCACA CCGACGGTCTCACCATAAAA CGCGTGCATG 251 GCGCGGATGT GGTTCAAAAT GGCGGCTCTG CATTCTGCCAAACTCAAGGC 301 AGGCGGTAAA ACGCCGTGTT CGGCATAATG CTTCAAATCG CGGAAAAACC351 ACGGCCTGCC TTGCGCGCCG CGCCCTATCA TGATGCCGTC GGCGGCGGTT 401TGTTTGAGGA cggCGGCGGC TTTTTgcggc GAagtGATGT CGCCGTTGac 451 cCaggCCGGGATGTTCAGAc ggCTTTTGGT CTCGGcgatg agttCGTAAC 501 gcGCCTCGCC TTTGTACATTTGCGTGcgcG CGcgcccgtg aacggcaaGg 551 gcggcaatgc cgcaatcttc ggcgattttggcgacggcgG gcaggttttg 601 atcgtcgtcg tgccaaccca AacggGTTTT GaggGTAACGGGTAcgcCCG 651 CCGCCTTgac caccgcctcc aAAatggcGg caaccagcgg CTCGTCCTGC701 ATCagcGCGC TACCGGCTTG GACGTTGCAC ACTTTCttgg cgggGCAGCC 751CATAttgATG TCGATGACCT GCGCCCCGAG TCCGACGTTg taacgcgccg 801 catCCGCCATCtgttcggGG TCGCTGCCGG CAATCTGCAC GGCAACGATG 851 CCGccttcat cggcaAAAtcactgcggtgc aGGGTTTTTC CGGTATTCCT 901 GAGCGTCGGA TCGCTGGCCA GCATTTCGCACACCGCCCAA CCTGCGCCAA 951 ACGCCCGACA GAGGCGGCGG AAGGGTTTGT CGGCAATGCCCGCCATCGGC 1001 GCAAGTGCGA TGGGGTTGTC GATAAAATAA CCGCCGATGT GCATAATGGG1051 CCCGCGTTTC AAAAAAGTGC GCCATTGTAC ATTTTTTAAThis corresponds to the amino acid sequence <SEQ ID 2710; ORF 902.ng>:

g902.pep 1 MPSEPERRHG NTALPFPIAA RPTVGFSGKP FKITGKCVVL RRRIVQAVDF 51TPRLFAVGHF ADVPAYVFAC DAHTDGLTIK RVHGADVVQN GGSAFCQTQG 101 RR*NAVFGIMLQIAEKPRPA LRAAPYHDAV GGGLFEDGGG FLRRSDVAVD 151 PGRDVQTAFG LGDEFVTRLAFVHLRARAPV NGKGGNAAIF GDFGDGGQVL 201 IVVVPTQTGF EGNGYARRLD HRLQNGGNQRLVLHQRATGL DVAHFLGGAA 251 HIDVDDLRPE SDVVTRRIRH LFGVAAGNLH GNDAAFIGKITAVQGFSGIP 301 ERRIAGQHFA HRPTCAKRPT EAAEGFVGNA RHRRKCDGVV DKITADVHNG351 PAFQKSAPLY IF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2711>:

m902.seq 1 TTGCACTTTC AAAGGATAAT CAAGTGTTCA GAAGGCATTT GGGCGGTAGG 51CGCACGCCCA ACTGTCGGTT TTTTCGGCAA GTCTTTCAAG ATAACCTGCA 101 AGCATGTCGTATTGCGCCGC CGCACTGTCC AAGCGGTTGA TTTCACGACG 151 TgTCTgTTCG CCGTcGGGCATTTCGTCGAT GTACCAGCCT ATGTGTTTGC 201 GTGCGATGCG CACACCGGCG GTGTCGCCGTAAAACGCGTG TATGGCGCGG 251 ATGTGGTTCA AAATAGCGGC GGCGCATTCT GCCAAACTCAAGGCAGGCGG 301 CAAAACACCG TGTTCGGCAT AATGTTTCAA ATCGCGGAAG AACCACGGCC351 TGCCTTGCGC GCCGCGCCCT ATCATAATGC CGTCGGCGGC GGTTTGTTTG 401AGGACGGCTT GGGCTTTTTG CGGCGAAGTA ATGTCGCCGT TGACCCAGAC 451 CGGGATGTTCAGACGGCATT TGGTTTCGGC GATGAGTTCG TAACGCGCTT 501 CGCCTTTGTA CATTTGCGTACGCGTGCGTC CGTGGACGGC AAGGGCGGCG 551 ATGCCGCAAT CTTCGGCGAT TTTGGCGATGACGGGCAGGT TTTGATGGTC 601 GTCGTGCCAA CCCAAACGGG TTTTGAGGGT AACGGGTACGCCTGCCGCAC 651 GGACGACGGC TTCCAAAATG GCGGCAACCA GCGGCTCGTT CTGCATCAGC701 GCGCTACCGG CTTGGACATT GCAGACTTTT TTAGCGGGAC AGCCCATGTT 751GATGTCGATA AGCTGCGCCC CAAGGCTGAC GTTGTAACGC GCGGCATCCG 801 CCATCTGCTGCGGATCGCTT CCGGCAATCT GCACGGCAAC AATGCCGCCT 851 TCATCGGCAA AATCGCTGCGGTGCAAGGTT TTTCTAGTAT TTCTGAGCGT 901 CGGGTCGCTG GTCAGCATTT CGCACACCGCCCAACCTGCG CCAAAATCTC 951 GGCAAAGTCG GCGGAACGGT TTGTCGGTAA TGCCCGCCATCGGcGCaAGT 1001 GCGATGGGGT TGTCGATAAA ATAGCCGCCG ATGTGCATAA TGGATCCGCG1051 TTTCAAAAAA GTACGCCATT GTACATTTTT TAAThis corresponds to the amino acid sequence <SEQ ID 2712; ORF 902>:

m902.pep 1 LHFQRIIKCS EGIWAVGARP TVGFFGKSFK ITCKHVVLRR RTVQAVDFTT 51CLFAVGHFVD VPAYVFACDA HTGGVAVKRV YGADVVQNSG GAFCQTQGRR 101 QNTVFGIMFQIAEEPRPALR AAPYHNAVGG GLFEDGLGFL RRSNVAVDPD 151 RDVQTAFGFG DEFVTRFAFVHLRTRASVDG KGGDAAIFGD FGDDGQVLMV 201 VVPTQTGFEG NGYACRTDDG FQNGGNQRLVLHQRATGLDI ADFFSGTAHV 251 DVDKLRPKAD VVTRGIRHLL RIASGNLHGN NAAFIGKIAAVQGFSSISER 301 RVAGQHFAHR PTCAKISAKS AERFVGNARH RRKCDGVVDK IAADVHNGSA351 FQKSTPLYIF *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 902 shows 80.9% identity over a 345 aa overlap with a predicted ORF(ORF 902.ng) from N. gonorrhoeae:

m902/g902            10        20        30        40        50 m902.pep   LHFQRIIKCSEGIWAVGARPTVGFFGKSFKITCKHVVLRRRTVQAVDFTTCLFAVGHF                  ::||||||| || |||| | |||||| ||||||| ||||||| g902 MPSEPERRHGNTALPFPIAARPTVGFSGKPFKITGKCVVLRRRIVQAVDFTPRLFAVGHF         10        20        30        40        50        60 60        70        80        90       100       110 m902.pep VDVPAYVFACDAHTGGVAVKRVYGADVVQNSGGAFCQTQGRRQNTVFGIMFQIAEEPRPA :||||||||||||| |:::|||:|||||||:|:||||||||| |:|||||:||||:|||| g902 ADVPAYVFACDAHTDGLTIKRVHGADVVQNGGSAFCQTQGRRXNAVFGIMLQIAEKPRPA         70        80        90       100       110       120120       130       140       150       160       170 m902.pep LRAAPYHNAVGGGLFEDGLGFLRRSNVAVDPDRDVQTAFGFGDEFVTRFAFVHLRTRASV |||||||:|||||||||| ||||||:||||| ||||||||:|||||||:||||||:|| | g902 LRAAPYHDAVGGGLFEDGGGFLRRSDVAVDPGRDVQTAFGLGDEFVTRLAFVHLRARAPV        130       140       150       160       170       180180       190       200       210       220       230 m902.pep DGKGGDAAIFGDFGDDGQVLMVVVPTQTGFEGNGYACRTDDGFQNGGNQRLVLHQRATGL :||||:||||||||| ||||:||||||||||||||| | |  :||||||||||||||||| g902 NGKGGNAAIFGDFGDGGQVLIVVVPTQTGFEGNGYARRLDHRLQNGGNQRLVLHQRATGL        190       200       210       220       230       240240       250       260       270       280       290 m902.pep DIADFFSGTAHVDVDKLRPKADVVTRGIRHLLRIASGNLHGNNAAFIGKIAAVQGFSSIS |:| |::|:||:||| |||::||||| ||||: :|:||||||:|||||||:||||||:| g902 DVAHFLGGAAHIDVDDLRPESDVVTRRIRHLFGVAAGNLHGNDAAFIGKITAVQGFSGIP        250       260       270       280       290       300300       310       320       330       340       350 m902.pep ERRVAGQHFAHRPTCAKISAKSAERFVGNARHRRKCDGVVDKIAADVHNGSAFQKSTPLY |||:|||||||||||||  :::|| ||||||||||||||||||:|||||| |||||:||| g902 ERRIAGQHFAHRPTCAKRPTEAAEGFVGNARHRRKCDGVVDKITADVHNGPAFQKSAPLY        310       320       330       340       350       360 360m902.pep  IFX  ||| g902  IFXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2713>:

a902.seq 1 TTGCACTTTC AAAGGATAAT CAAGTGTTCA GAAGGCATTT GGGCGGTAGG 51CGCACGCCCA ACTGTCGGTT TTTTCGGCAA GTCTTTCAAG ATAACCTGCA 101 AACATGTCGTATTGCGCCGC CGCACTGTCC AAGCGGTTGA TTTCACGACG 151 TGTCTGTTCG CCGTCGGGCATTTCGTCGAT GTACCAGCCT ATGTGTTTGC 201 GTGCGATGCG CACACCGGCG GTGTCGCCGTAAAACGCGTG CATGGCTCGG 251 ATGTGGTTCA AAATAGTGGC GGTACATTCT GCCAAACTCAAGGCAGGCGG 301 TAAAACACCG TGTTCGGCGT AATGTTTCAA ATCGCGGAAG AACCACGGTC351 TGCCTTGCGC GCCGCGCCCT ATCATAATGC CGTCTGCGGC GGTTTGTTTG 401AGGACGGCTT GGGCTTTTTG CGGCGAGGTA ATGTCGCCGT TGACCCAGAC 451 CGGGATGTTCAGACGGCATT TGGTTTCGGC AATCAGGTCG TAAGCCGCTT 501 CGCCTTTGTA CATTTGCGTGCGCGTGCGTC CGTGGACGGC AAGGGCGGCA 551 ATGCCGCAAT CTTCGGCGAT TTTGGCGATGACGGGCAGGT TTTGATGGTC 601 GTCGTGCCAA CCCAAACGGG TTTTGAGGGT AACGGGTACGCCCGCCGCTT 651 TGACCACCGC CTCCAAAATG GCGGCAACCA GCGGCTCGTT CTGCATCAGC701 GCGCTACCGG CTTGGACATT GCAGACTTTT TTAGCGGGAC AGCCCATGTT 751GATGTCGATA AGCTGCGCCC CAAGGCTGAC GTTGTAACGC GCGGCATCCG 801 CCATCTGCTGCGGATCGCTT CCGGCAATCT GCACGGCAAC AATGCCGCCT 851 TCATCGGCAA AATCGCTGCGGTGCAAGGTT TTTCTAGTAT TTCTGAGCGT 901 CGGGTCGCTG GTCAGCATTT CGCACACCGCCCAACCTGCG CCAAAATCTC 951 GGCAAAGTCG GCGGAACGGT TTGTCGGTAA TGCCCGCCATCGGCGCAAGT 1001 GCGATGGGGT TGTCGATAAA ATAGCCGCCG ATGTGCATAA TGGATCCGCG1051 TTTCAAAAAA GTACGCCATT GTACATTTTT TAAThis corresponds to the amino acid sequence <SEQ ID 2714; ORF 902.a>:

a902.pep 1 LHFQRIIKCS EGIWAVGARP TVGFFGKSFK ITCKHVVLRR RTVQAVDFTT 51CLFAVGHFVD VPAYVFACDA HTGGVAVKRV HGSDVVQNSG GTFCQTQGRR 101 *NTVFGVMFQIAEEPRSALR AAPYHNAVCG GLFEDGLGFL RRGNVAVDPD 151 RDVQTAFGFG NQVVSRFAFVHLRARASVDG KGGNAAIFGD FGDDGQVLMV 201 VVPTQTGFEG NGYARRFDHR LQNGGNQRLVLHQRATGLDI ADFFSGTAHV 251 DVDKLRPKAD VVTRGIRHLL RIASGNLHGN NAAFIGKIAAVQGFSSISER 301 RVAGQHFAHR PTCAKISAKS AERFVGNARH RRKCDGVVDK IAADVHNGSA351 FQKSTPLYIF * m902/a902 94.7% identity in 360 aa overlap        10        20        30        40        50        60 m902.pepLHFQRIIKCSEGIWAVGARPTVGFFGKSFKITCKHVVLRRRTVQAVDFTTCLFAVGHFVD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a902LHFQRIIKCSEGIWAVGARPTVGFFGKSFKITCKHVVLRRRTVQAVDFTTCLFAVGHFVD        10        20        30        40        50        60        70        80        90       100       110       120 m902.pepVPAYVFACDAHTGGVAVKRVYGADVVQNSGGAFCQTQGRRQNTVFGIMFQIAEEPRPALR||||||||||||||||||||:|:||||||||:|||||||| |||||:||||||||| ||| a902VPAYVFACDAHTGGVAVKRVHGSDVVQNSGGTFCQTQGRRXNTVFGVMFQIAEEPRSALR        70        80        90       100       110       120       130       140       150       160       170       180 m902.pepAAPYHNAVGGGLFEDGLGFLRRSNVAVDPDRDVQTAFGFGDEFVTRFAFVHLRTRASVDG|||||||| |||||||||||||: |||||||||||||||||:: |:||||||||:|||||| a902AAPYHNAVCGGLFEDGLGFLRRGNVAVDPDRDVQTAFGFGNQVVSRFAFVHLRARASVDG       130       140       150       160       170       180       190       200       210       220       230       240 m902.pepKGGDAAIFGDFGDDGQVLMVVVPTQTGFEGNGYACRTDDGFQNGGNQRLVLHQRATGLDI|||:|||||||||||||||||||||||||||||| | |  :||||||||||||||||||| a902KGGNAAIFGDFGDDGQVLMVVVPIQTGFEGNGYARRFDHRLQNGGNQRLVLHQRATGLDI       190       200       210       220       230       240       250       260       270       280       290       300 m902.pepADFFSGTAHVDVDKLRPKADVVTRGIRHLLRIASGNLHGNNAAFIGKIAAVQGFSSISER|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a902ADFFSGTAHVDVDKLRPKADVVTRGIRHLLRIASGNLHGNNAAFIGKIAAVQGFSSISER       250       260       270       280       290       300       310       320       330       340       350       360 m902.pepRVAGQHFAHRPTCAKISAKSAERFVGNARHRRKCDGVVDKIAADVHNGSAFQKSTPLYIF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a902RVAGQHFAHRPTCAKISAKSAERFVGNARHRRKCDGVVDKIAADVHNGSAFQKSTPLYIF       310       320       330       340       350       360 m902.pep X| a902 XThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2715>:

g903.seq 1 ATGGCAACAC AGGTAGGCGG TGCAAattcG gatgaggCAA GCCCCTGCTT 51TCCTATTTCT GAGGTGGAaT TGGTGGGTGA aGaaacggct aAATTCCGgt 101 tTGCGCTcaaccaTGCCTTG tgccAAACAC ATTTTGtttc cGgcaagtgt 151 CTGcATGcgg gcgacatTAATCAAAtcaTG TCCTTAGCAC AAAATGCTTT 201 GATCGGCAGG GGATATACCA CGACCCGTATCTTGGCTGCG CCACAGGATT 251 TGAATAGTGG caaGCTTCAA TTAAccctga tgccggGCTATCtgcgctcC 301 ATAcgaATCG atcggtccaa cgatgatcaa ACCCATgcAG GACGTATTGC351 AGCATTCCAA AACAAATTTC CCACCCGCTC GAACGATCTG TTGAATCTGC 401GTGATTTGGA ACAAGGACTG GAAAATCTCA AATGTCTCCC GACTGCGGAA 451 GCCGATCTCCAAATCgttcc cgtaGAGAGA GAACcAAACC AAAGTGATGT 501 CGTGGTGCAA TGGCGGTAACGTCTGCTGCC CTACTGTGTG AGTGTGGGGA 551 TGGATAATTC GGGTAGTGAG GCGACAGGAAAATACCAAGG AAATATCACT 601 TTCTCTGCCG ACAATCCTTT TggactgAGT GATATGTTCTATGTAAATTA 651 TGGACGTTCA ATTGGCGGTA CGcccgATGA GGAAAATTTT GACGGCCATC701 GCAAAGAAGG CGGATCAAAC AATTACGCCG TACATTATTC AGCCCCTTTC 751GGTAAATGGA CATGGGCATT CAATCACAAT GGCTACCGTT ACCATCAGGC 801 GGTTTCCGGATTATCGGAAG TCTATGACTA TAATGGAAAA AGTTACAACA 851 CTGATTTCGG CTTCAACCGCCTGTTGTATC GTGATGCCAA ACGCAAAACC 901 TATCTCAGTG TAAAACTGTG GACGAGGGAAACAAAAAGTT ACATTGATGA 951 TGCCGAACTG ACTGTACAAC GGCGTAAAAC CACAGGTTGGTTGGCAGAAC 1001 TTTCCCACAA AGGATATATC GGTCGCAGTA CGGCAGATTT TAAGTTGAAA1051 TATAAACACG GCACCGGCAT GAAAGATGCT CTGCGCGCGC CTGAAGAAGC 1101CTTTGGCGAA GGCACGTCAC GTATGAAAAT TTGGACGGCA TCGGCTGATG 1151 TAAATACTCCTTTTCAAATC GGTAAACAGC TATTTGCCTA TGACACATCC 1201 GTTCATGCAC AATGGAACAAAACCCCGCTA ACATCGCAAG ACAAACTGGC 1251 TATCGGCGGA CACCACACCG TACGTGGCTTCGACGGTGAA ATGAGTTTGC 1301 CTGCCGAGCG GGGATGGTAT TGGCGCAACG ATTTGAGCTGGCAATTTAAA 1351 CCAGGCCATC AGCTTTATCT TGGGGCTGAT GTAGGACATG TTTCAGGACA1401 ATCCGCCAAA TGGTTATCGG GCCAAACTCT AGCCGGCACA GCAATTGGGA 1451TACGCGGGCA GATAAAGCTT GGCGGCAACC TGCATTACGA TATATTTACC 1501 GGCCGTGCATTGAAAAAGCC cgaatatttt cAGACGAAGA Aatgggtaac 1551 ggggtTTCAG gtgggttattcgTTTTGAThis corresponds to the amino acid sequence <SEQ ID 2716; ORF 903.ng>:

g903.pep 1 MATQVGGANS DEASPCFPIS EVELVGEETA KFRFALNHAL CQTHFVSGKC 51LHAGDINQIM SLAQNALIGR GYTTTRILAA PQDLNSGKLQ LTLMPGYLRS 101 IRIDRSNDDQTHAGRIAAFQ NKFPTRSNDL LNLRDLEQGL ENLKCLPTAE 151 ADLQIVPVER EPNQSDVVVQWRXRLLPYCV SVGMDNSGSE ATGKYQGNIT 201 FSADNPFGLS DMFYVNYGRS IGGTPDEENFDGHRKEGGSN NYAVHYSAPF 251 GKWTWAFNHN GYRYHQAVSG LSEVYDYNGK SYNTDFGFNRLLYRDAKRKT 301 YLSVKLWTRE TKSYIDDAEL TVQRRKTTGW LAELSHKGYI GRSTADFKLK351 YKHGTGMKDA LRAPEEAFGE GTSRMKIWTA SADVNTPFQI GKQLFAYDTS 401VHAQWNKTPL TSQDKLAIGG HHTVRGFDGE MSLPAERGWY WRNDLSWQFK 451 PGHQLYLGADVGHVSGQSAK WLSGQTLAGT AIGIRGQIKL GGNLHYDIFT 501 GRALKKPEYF QTKKWVTGFQVGYSF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2717>:

m903.seq 1 ATGCAGCGTC AGCAGCACAT AGATGCTGAA TTGTTAACTG ATGCAAATGT 51CCGTTTCGAG CAACCATTGG AGAAGAACAA TTATGTCCTG AGTGAAGATG 101 AAACACCGTGTACTCGGGTA AATTACATTA GTTTAGATGA TAAGACGGTG 151 CGCAAATTTT CTTTTCTTCCTTCTGTGCTC ATGAAAGAAA CAGCTTTTAA 201 AACTGGGATG TGTTTAGGTT CCAATAATTTGAGCAGGCTA CAAAAAGCCG 251 CGCAACAGAT ACTGATCGTG CGTGGCTACC TCACTTCCCAAGCTATTATC 301 CAaCCACAGA ATATGGATTC GGGAATTCTG AAATTACGGG TATCAGCAGG351 CGAAATAGGG GATATCCGCT ATGAAGAAAA ACGGGATGGG AAGTCTGCCG 401AGGGCAGTAT TAGTGCATTC AATAACAAAT TTCCCTTATA TAGGAACAAA 451 ATTCTCAATCTTCGCGATGT AGAGCAGGGC TTGGAAAACC TGCGTCGTTT 501 GCCGAGTGTT AAAACAGATATTCAGATTAT ACCGTCCGAA GAAGAAGGCA 551 AAAGCGATTT ACAGATCAAA TGGCAGCAGAATAAACCCAT ACGGTTCAGT 601 ATCGGTATAG ATGATGCGGG CGGCAAAACG ACCGGCAAATATCAAGGAAA 651 TGTCGCTTTA TCGTTCGATA ACCCTTTGGG CTTAAGCGAT TTGTTtTATG701 TTTCATATGG ACGCGGTTTG GCGCACAAAA CGGACTTGAC TGATGCCACC 751GGTACGGAAA CTGAAAGCGG ATCCAGAAGT TACAGCGTGC ATTATTCGGT 801 GCCCGTAAAAAAATGGCTGT TTTCTTTTAA TCACAATGGA CATCGTTACC 851 ACGAAGCAAC CGAAGGCTATTCCGTCAATT ACGATTACAA CGGCAAACAA 901 TATCAGAGCA GCCTGGCCGC CGAGCGCATGCTTTGGCGTA ACAGACTTCA 951 TAAAACTTCA GTCGGAATGA AATTATGGAC ACGCCAAACCTATAAATACA 1001 TCGACGATGC CGAAATCGAA GTACAACGCC GCCGCTCTGC AGGCTGGGAA1051 GCCGAATTGC GCCACCGTGC TTACCTCAAC CGTTGGCAGC TTGACGGCAA 1101GTTGTCTTAC AAACGCGGGA CCGGCATGCG CCAAAGTATG CCTGCACCGG 1151 AAGAAAACGGCGGCGATATT CTTCCAGGTA CATCTCGTAT GAAAATCATT 1201 ACTGCCAGTT TGGACGCAGCCGCCCCATTT AyTTTAGGCA AACAGCAGTT 1251 TTTCTACGCA ACCGCCATTC AAGCTCAATGGAACAAAACG CCGTTGGTTG 1301 CCCAAGATAA ATTGTCAATC GGCAGCCGCT ACACCGTTCGCGGATTTGAT 1351 GGGGAGCAGA GTCTTTTCGG AGAGCGAGGT TTCTACTGGC AGAATACTTT1401 AACTTGGTAT TTTCATCCGA ACCATCAGTT CTATCTCGGT GCGGACTATG 1451GCCGCGTATC TGGCGAAAGT GCACAATATG TATCGGGCAA GCAGCTGATG 1501 GGTGCAGTGGTCGGCTTCAG AGGAGGGCAT AAAGTAGGCG GTATGTTTGC 1551 TTATGATCTG TTTGCCGGCAAGCCGCTTCA TAAACCCAAA GGCTTTCAGA 1601 CGACCAACAC CGTTTACGGC TTCAACTTGAATTACAGTTT CTAAThis corresponds to the amino acid sequence <SEQ ID 2718; ORF 903>:

m903.pep 1 MQRQQHIDAE LLTDANVRFE QPLEKNNYVL SEDETPCTRV NYISLDDKTV 51RKFSFLPSVL MKETAFKTGM CLGSNNLSRL QKAAQQILIV RGYLTSQAII 101 QPQNMDSGILKLRVSAGEIG DIRYEEKRDG KSAEGSISAF NNKFPLYRNK 151 ILNLRDVEQG LENLRRLPSVKTDIQIIPSE EEGKSDLQIK WQQNKPIRFS 201 IGIDDAGGKT TGKYQGNVAL SFDNPLGLSDLFYVSYGRGL AHKTDLTDAT 251 GTETESGSRS YSVHYSVPVK KWLFSFNHNG HRYHEATEGYSVNYDYNGKQ 301 YQSSLAAERM LWRNRLHKTS VGMKLWTRQT YKYIDDAEIE VQRRRSAGWE351 AELRHRAYLN RWQLDGKLSY KRGTGMRQSM PAPEENGGDI LPGTSRMKII 401TASLDAAAPF XLGKQQFFYA TAIQAQWNKT PLVAQDKLSI GSRYTVRGFD 451 GEQSLFGERGFYWQNTLTWY FHPNHQFYLG ADYGRVSGES AQYVSGKQLM 501 GAVVGFRGGH KVGGMFAYDLFAGKPLHKPK GFQTTNTVYG FNLNYSF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 903 shows 48.9% identity over a 519 aa overlap with a predicted ORF(ORF 903.ng) from N. gonorrhoeae:

m903/g903           10        20        30        40        50        60m903.pep   MQRQQHIDAELLTDANVRFEQPLEKNNYVLSEDETPCTRVNYISLDDKTVRKFSFLPSVL                                |:: :||  :: : |  : : || |  : g903                       MATQVGGANSDEASPCFPISEVELVGEETAKFRFALNHA                               10        20        30          70        80        90       100       110       120 m903.pep  MKETAFKTGMCLGSNNLSRLQKAAQQILIVRGYLTSQAIIQPQNMDSGILKLRVSAGEIG   ::| | :| || ::::::::: ||: || ||| |:: :  ||:::|| |:| :  | : g903  LCQTHFVSGKCLHAGDINQIMSLAQNALIGRGYTTTRILAAPQDLNSGKLQLTLMPGYLR 40        50        60        70        80        90         130       140       150       160       170       180 m903.pep  DIRYEEKRDGKSAEGSISAFNNKFPLYRNKILNLRDVEQGLENLRRLPSVKTDIQIIPSE   :|| :::| ::  | |:||:||||   | :|||||:|||||||: ||::::|:||:| | g903  SIRIDRSNDDQTHAGRIAAFQNKFPTRSNDLLNLRDLEQGLENLKCLPTAEADLQIVPVE100       110       120       130       140       150          190        200       210       220       230 m903.pep  EE-GKSDLQIKWQQNK-PIRFSIGIDDAGGKTTGKYQGNVALSFDNPLGLSDLFYVSYGR  :| ::||: ::|    |   |:|:|::|:::|||||||:::| |||:||||:|||:||| g903  REPNQSDVVVQWRXRLLPYCVSVGMDNSGSEATGKYQGNITFSADNPFGLSDMFYVNYGR160       170       180       190       200       210 240       250       260       270       280       290 m903.pep  GLAHKTDLTDATGTETESGSRSYSVHYSVPVKKWLFSFNHNGHRYHEATEGYSVNYDYNG  :::   |  :  | : |:|| :|:||||:|  || ::|||||:|||:|: | |  ||||| g903  SIGGTPDEENFDGHRKEGGSNNYAVHYSAPFGKWTWAFNHNGYRYHQAVSGLSEVYDYNG220       230       240       250       260       270 300       310       320       330       340       350 m903.pep  KQYQSSLAAERMLWRNRLHKTSVGMKLWTRQTYKYIDDAEIEVQRRRSAGWEAELRHRAY  |:|::::: :|:|:|:  :|| :::|||||:| :||||||: ||||:::|| ||| |::| g903  KSYNTDFGFNRLLYRDAKRKTYLSVKLWTRETKSYIDDAELTVQRRKTTGWLAELSHKGY280       290       300       310       320       330 360       370       380       390       400       410 m903.pep  LNRWQLDGKLSYKRGTGMRQSMPAPEENGGDILPGTSRMKIITASLDAAAPFXLGKQQFF  ::|   | ||:||:||||:::: ||||  |:   ||||||| ||| |: :|| :||| | g903  IGRSTADFKLKYKHGTGMKDALRAPEEAFGE---GTSRMKIWTASADVNTPFQIGKQLFA340       350       360       370          380       390 420       430       440       450       460       470 m903.pep  YATAIQAQWNKTPLVAQDKLSIGSRYTVRGFDGEQSLFGERGFYWQNTLTWYFHPNHQFY  | |:::||||||||::||||:||:::||||||||:|| :|||:||:| |:| |:|:||:| g903  YDTSVHAQWNKTPLTSQDKLAIGGHHTVRGFDGEMSLPAERGWYWRNDLSWQFKPGHQLY   400       410       420       430       440       450 480       490       500       510       520       530 m903.pep  LGADYGRVSGESAQYVSGKQLMGAVVGFRGGHKVGGMFAYDLFAGKPLHKPKGFQTTNTV  |||| |:|||:||:::||: | |:::|:||  |:|| : ||:|:|: |:||: ||| : | g903  LGADVGHVSGQSAKWLSGQTLAGTAIGIRGQIKLGGNLHYDIFTGRALKKPEYFQTKKWV   460       470       480       490       500       510  540 m903.pep  YGFNLNYSFX    ||:::|||| g903   TGFQVGYSFX    520The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2719>:

a903.seq 1 ATGCAGCGTC AGCAGCACAT AGATGCTGAA TTGTTAACTG ATGCAAATGT 51CCGTTTCGAG CAACCATTGG AGAAGAACAA TTATGTCCTG AGTGAAGATG 101 AAACACCGTGTACTCGGGTA AATTACATTA GTTTAGATGA TAAGACGGCG 151 CGCAAATTTT CTTTTCTTCCTTCTGTGCTC ATGAAAGAAA CAGCTTTTAA 201 AACTGGGATG TGTTTAGGTT CCAATAATTTGAGCAGGCTA CAAAAAGCCG 251 CGCAACAGAT ACTGATTGTG CGTGGCTACC TCACTTCCCAAGCTATTATC 301 CAACCACAGA ATATGGATTC GGGAATTCTG AAATTACGGG TATCAGCAGG351 CGAAATAGGG GATATCCGCT ATGAAGAAAA ACGGGATGGG AAGTCTGCCG 401AGGGCAGTAT TAGTGCATTC AATAACAAAT TTCCCTTATA TAGGAACAAA 451 ATTCTCAATCTTCGCGATGT AGAGCAGGGC TTGGAAAACC TGCGTCGTTT 501 GCCGAGTGTT AAAACAGATATTCAGATTAT ACCGTCCGAA GAAGAAGGCA 551 AAAGCGATTT ACAGATCAAA TGGCAGCAGAATAAACCCAT ACGGTTCAGT 601 ATCGGTATAG ATGATGCGGG CGGCAAAACG ACCGGCAAATATCAAGGAAA 651 TGTCGCTTTA TCGTTCGATA ACCCTTTGGG CTTAAGCGAT TTGTTTTATG701 TTTCATATGG ACGCGGTTTG GTGCACAAAA CGGACTTGAC TGATGCCACC 751GGTACGGAAA CTGAAAGCGG ATCCAGAAGT TACAGCGTGC ATTATTCGGT 801 GCCCGTAAAAAAATGGCTGT TTTCTTTTAA TCACAATGGA CATCGTTACC 851 ACGAAGCAAC CGAAGGCTATTCCGTCAATT ACGATTACAA CGGCAAACAA 901 TATCAGAGCA GCCTGGCCGC CGAGCGCATGCTTTGGCGTA ACAGGTTTCA 951 TAAAACTTCA GTCGGAATGA AATTATGGAC ACGCCAAACCTATAAATACA 1001 TCGACGATGC CGAAATCGAA GTGCAACGCC GCCGCTCTGC AGGCTGGGAA1051 GCCGAATTGC GCCACCGTGC TTACCTCAAC CGTTGGCAGC TTGACGGCAA 1101GTTGTCTTAC AAACGCGGGA CCGGCATGCG CCAAAGTATG CCCGCACCTG 1151 AAGAAAACGGCGGCGGTACT ATTCCAGGCA CATCCCGTAT GAAAATCATA 1201 ACCGCCGGAT TGGATGCAGCGGCCCCGTTT ATGTTGGGCA AACAGCAGTT 1251 TTTCTACGCA ACCGCCATTC AAGCTCAATGGAACAAAACG CCTTTGGTTG 1301 CCCAAGACAA GTTGTCTATC GGCAGCCGCT ACACCGTTNGCGGATTTGAT 1351 GGGGAGCAGA GTCTTTTCGG AGAGCGAGGT TTCTACTGGC AGAATACTTT1401 AACTTGGTAT TTTCATCCGA ACCATCAGTT CTATCTCGGT GCGGACTATG 1451GCCGCGTATC TGGCGAAAGT GCACAATATG TATCGGGCAA GCAGCTGATG 1501 GGTGCAGTGGTCGGNTTCAG AGGAGGNCAT AAAGTAGGCG GTATGTTTGC 1551 TTATGATCTG TTTGCCGGCAAGCCGCTTCA TAAACCCAAA GGCTTTCAGA 1601 CGACCAACAC CGTTTACGGC TTCAACTTGAATTACAGTTT CTAAThis corresponds to the amino acid sequence <SEQ ID 2720; ORF 903.a>:

a903.pep 1 MQRQQHIDAE LLTDANVRFE QPLEKNNYVL SEDETPCTRV NYISLDDKTA 51RKFSFLPSVL MKETAFKTGM CLGSNNLSRL QKAAQQILIV RGYLTSQAII 101 QPQNMDSGILKLRVSAGEIG DIRYEEKRDG KSAEGSISAF NNKFPLYRNK 151 ILNLRDVEQG LENLRRLPSVKTDIQIIPSE EEGKSDLQIK WQQNKPIRFS 201 IGIDDAGGKT TGKYQGNVAL SFDNPLGLSDLFYVSYGRGL VHKTDLTDAT 251 GTETESGSRS YSVHYSVPVK KWLFSFNHNG HRYHEATEGYSVNYDYNGKQ 301 YQSSLAAERM LWRNRFHKTS VGMKLWTRQT YKYIDDAEIE VQRRRSAGWE351 AELRHRAYLN RWQLDGKLSY KRGTGMRQSM PAPEENGGGT IPGTSRMKII 401TAGLDAAAPF MLGKQQFFYA TAIQAQWNKT PLVAQDKLSI GSRYTVXGFD 451 GEQSLFGERGFYWQNTLTWY FHPNHQFYLG ADYGRVSGES AQYVSGKQLM 501 GAVVGFRGGH KVGGMFAYDLFAGKPLHKPK GFQTTNTVYG FNLNYSF* m903/a903 98.4% identity in 547 aaoverlap         10        20        30        40        50        60m903.pep MQRQQHIDAELLTDANVRFEQPLEKNNYVLSEDETPCTRVNYISLDDKTVRKFSFLPSVL|||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||| a903MQRQQHIDAELLTDANVRFEQPLEKNNYVLSEDETPCTRVNYISLDDKTARKFSFLPSVL        10        20        30        40        50        60        70        80        90       100       110       120 m903.pepMKETAFKTGMCLGSNNLSRLQKAAQQILIVRGYLTSQAIIQPQNMDSGILKLRVSAGEIG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a903MKETAFKIGMCLGSNNLSRLQKAAQQILIVRGYLTSQAIIQPQNMDSGILKLRVSAGEIG        70        80        90       100       110       120       130       140       150       160       170       180 m903.pepDIRYEEKRDGKSAEGSISAFNNKFPLYRNKILNLRDVEQGLENLRRLPSVKTDIQIIPSE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a903DIRYEEKRDGKSAEGSISAFNNKFPLYRNKILNLRDVEQGLENLRRLPSVKIDIQIIPSE       130       140       150       160       170       180       190       200       210       220       230       240 m903.pepEEGKSDLQIKWQQNKPIRFSIGIDDAGGKTTGKYQGNVALSFDNPLGLSDLFYVSYGRGL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a903EEGKSDLQIKWQQNKPIRFSIGIDDAGGKTTGKYQGNVALSFDNPLGLSDLFYVSYGRGL       190       200       210       220       230       240       250       260       270       280       290       300 m903.pepAHKTDLTDATGTETESGSRSYSVHYSVPVKKWLFSFNHNGHRYHEATEGYSVNYDYNGKQ:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a903VHKTDLTDATGTETESGSRSYSVHYSVPVKKWLFSFNHNGHRYHEATEGYSVNYDYNGKQ       250       260       270       280       290       300       310       320       330       340       350       360 m903.pepYQSSLAAERMLWRNRLHKTSVGMKLWTRQTYKYIDDAEIEVQRRRSAGWEAELRHRAYLN|||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||| a903YQSSLAAERMLWRNRFHKTSVGMKLWTRQTYKYIDDAEIEVQRRRSAGWEAELRHRAYLN       310       320       330       340       350       360       370       380       390       400       410       420 m903.pepRWQLDGKLSYKRGTGMRQSMPAPEENGGDILPGTSRMKIITASLDAAAPFXLGKQQFFYA||||||||||||||||||||||||||||  :|||||||||||:||||||| ||||||||| a903RWQLDGKLSYKRGTGMRQSMPAPEENGGGTIPGTSRMKIITAGLDAAAPFMLGKQQFFYA       370       380       390       400       410       420       430       440       450       460       470       480 m903.pepTAIQAQWNKTPLVAQDKLSIGSRYTVRGFDGEQSLFGERGFYWQNTLTWYFHPNHQFYLG|||||||||||||||||||||||||| ||||||||||||||||||||||||||||||||| a903TAIQAQWNKTPLVAQDKLSIGSRYTVXGFDGEQSLFGERGFYWQNTLTWYFHPNHQFYLG       430       440       450       460       470       480       490       500       510       520       530       540 m903.pepADYGRVSGESAQYVSGKQLMGAVVGFRGGHKVGGMFAYDLFAGKPLHKPKGFQTTNTVYG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a903ADYGRVSGESAQYVSGKQLMGAVVGFRGGHKVGGMFAYDLFAGKPLHKPKGFQTTNTVYG       490       500       510       520       530       540 m903.pepFNLNYSFX |||||||| a903 FNLNYSFXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2721>:

g904.seq 1 ATGATGCAGC ACAATCGTTT CTTCGCGGTC GGGGCCGGTg gaGACGATGG 51CGACCGGCGC GCCGCAGACT TCTTCAATCC GTTTCAAATA TGCTTTGGCA 101 TTGGCAGGCAATGCGTCGTA GCTTTTCACG CCGACAGTCG ATTCGCGCCA 151 GCCGGGCATG GTTTCGTAAATCGGTTTGCA GGTTTCCACC GCATCCGAAC 201 CGCAAGGCAG GATGTCGGTT TTGCCGCCGCCTGGCAATTC GTAGCCGACG 251 CAGATATTGA TGGTTTCAAC GCCGTCCATT ACATCGAGTTTGGTAATGCA 301 CATACCGGAA ATGCCGTTGA TTTGGATGGA GCGTTTCAGG GCGGCGGCAT351 CAAACCAGCC GCAGCGGCGC GCGCGGCCGG TTACCGAACC GAATTCGTGT 401CCGCGCTCCG CCAAACCTGC GCCTACTTCG TCGAACAATT CGGTCGGGAA 451 CGGGCCCGAACCGACGCGCG TGGTATAGGC TTTGACGATG CCCAAAACAT 501 AATCCAGCAT TTGAGGACCTACGCCCGCGC CTGCCGAAGC CGCGCCGGCG 551 AGACAGTTGG ACGAGGTAAC GAAGGGGTAAGTGCCGTAGT CGATGTCCAA 601 CAACGCACCT TGCGCGCCTT CAAACAGCAG TTTTTCGCCGTTTTTGTTTT 651 TTTCGTTCAA CACGCgggaC acgtcgGCAA TCATCGGCGC AATGCGCGGC701 GCGACTTTTT CGATAACCGC CATCACGTCT TCCGCTTTAA CCGGTCCGGC 751GTTATGCAGG TATTGGAGTT GGACGTTGTA ATAGGCAAGG ACGGCATCCA 801 GTTTTTCACGCAGTTTTTCA GGATGCAGCA AATCGGCGGC GCGAATGGCG 851 CGGCGTGCCA CTTTGTCTTCGTAGGCAGGG CCGATGCCGC GGCCGGTCGT 901 GCCGATTTTG CCTTTGCCGC GCGATGCTTCGCGGGCTTGG TCGAGCGCGA 951 TGTGGTAAGG CAGGATCAGC GGGCAGGTCG GCGCGATTTTCAGACGGCCT 1001 TCGACGTTTT TCACGCCTGC CGCGTTCAAC TCGTCGATTT CGCCCAACAG1051 GGCTTCGGGg gaaacgAcaa cGCCCGAACC gatGAAGCAA TCCAATCCTT 1101CGTGCAGGAT ACCGCTCGGA ATCAGGCGCA AAATGGTTTT TTTGCCGCCG 1151 ACGACCAAGGTATGGCCCGC ATTGTGGCCG CCTTGGAAGC GCACgacGct 1201 gCCGGCTTCT TCCGCCAGCCAGTCAACGAT TTTACCTTTA CCCTCGTCGC 1251 CCCACTGTgc gccGATTACT ACAACATTTTTAGCCATAGC CATATAACCT 1301 ATCGatatTA AThis corresponds to the amino acid sequence <SEQ ID 2722; ORF 904.ng>:

g904.pep 1 MMQHNRFFAV GAGGDDGDRR AADFFNPFQI CFGIGRQCVV AFHADSRFAP 51AGHGFVNRFA GFHRIRTARQ DVGFAAAWQF VADADIDGFN AVHYIEFGNA 101 HTGNAVDLDGAFQGGGIKPA AAARAAGYRT EFVSALRQTC AYFVEQFGRE 151 RARTDARGIG FDDAQNIIQHLRTYARACRS RAGETVGRGN EGVSAVVDVQ 201 QRTLRAFKQQ FFAVFVFFVQ HAGHVGNHRRNARRDFFDNR HHVFRFNRSG 251 VMQVLELDVV IGKDGIQFFT QFFRMQQIGG ANGAACHFVFVGRADAAAGR 301 ADFAFAARCF AGLVERDVVR QDQRAGRRDF QTAFDVFHAC RVQLVDFAQQ351 GFGGNDNART DEAIQSFVQD TARNQAQNGF FAADDQGMAR IVAALEAHDA 401AGFFRQPVND FTFTLVAPLC ADYYNIFSHS HITYRY*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2723>:

m904.seq 1 ATGATGCAGC ACAATCGTTT CTTCTCGGTC GGGGCCGgTG GAGACGATGG 51CGACCGGCGC GCCGCAGACT TCTTCAATCC GTTTCAAATA TGCTTTGGCG 101 TTTTCGGGCAATGCGCCGTA GTCCTTCACG CCGAAAGTGG ATTCGCGCCA 151 GCCGGGCATG GTTTCGTAAATCGGCTTGCA GGTTTCCACC GCATCGGAAC 201 CGCAAGGCAG GATGTCGGTT TTGCCGCCGTCGGGCAATTC ATAGCCGACG 251 CAGATATTGA TGGTTTCAAC GCCGTCCATT ACATCGAGTTTAGTAATACA 301 CATACCGGAA ATGCCGTTGA TTTGGATGGA GCGTTTCAGG GCGGCGGCAT351 CAAACCAGCC GCAGCGGCGT GCGCGTCCGG TTACCGAACC GAATTCGTGT 401CCGCGTTCTG CCAAACCTAC GCCTACTTCG TCGAACAATT CGGTCGGGAA 451 CGGGCCCGAACCGACGCGCG TGGTATAGGC TTTGACGATG CCCAAAACAT 501 AATCCAGCAT TTGAGGACCTACGCCCGCGC CTGCCGAAGC TGCGCCCGCC 551 AGACAGTTGG ACGAGGTAAC GAAGGGATAAGTGCCGTAGT CGATGTCCAA 601 CAACGCACCT TGCGCGCCTT CAAACAGCAG TTTTTCGCCGTTTTTGTTTT 651 TCTCGTTCAA CACGCGGGAC ACGTCGGTAA TCATCGGCGC AATGCGCGGC701 GCGACTTTTT CGATAACCGC CATCACGTCT TCCGCTTTAA CCGGCTCGGC 751ATTGTGCAGA TGTTGCAGTT GGACATTGTA ATAGGCAAGG ACGGCATCCA 801 GTTTTTCACGCAGTTTyTCA GGATGCAGCA AATCGGCGGC GCGAATGGCG 851 CGGCGTGCCA CTTTGTCTTCGTAGGCAGGG CCGATGCCGC GGCCGGTCGT 901 GCCGATTTTG CCTTTGCCGC GCG.ATcTTCGCGGGCTTGG TCGAGCGCGA 951 TGTGGTAAGG CAGGATCAGC GGGCAGGTCG GCGCGATTTTCAGACGGCCT 1001 TCGACGTTTT TCACGCCTGC CGCGTTCAAC TCGTCGATTT CGCCCAACAG1051 GGCTTCGGGG GAGACGACAA CGCCCGAACC GATGAAGCAG TCCAAACTTT 1101CATGCAGGAT GCCGCTCGGA ATCAGGCGCA AAATGGTTTT TTTGCCGCCG 1151 ACAACCAAGGTATGGCCCGC ATTGTGGCCG CCTTGGAAGC GCACCaCGCC 1201 GCCGGCTTCT TCCGCCAGCCAGTCAACGAT TTTACCTTTA CCCTCGTCGC 1251 CCCACTGTGC GCCGATTAsT ACAACATTTTTAGCCATAGC CATATAACCT 1301 ATCGATATTA AThis corresponds to the amino acid sequence <SEQ ID 2724; ORF 904>:

m904.pep 1 MMQHNRFFSV GAGGDDGDRR AADFFNPFQI CFGVFGQCAV VLHAESGFAP 51AGHGFVNRLA GFHRIGTARQ DVGFAAVGQF IADADIDGFN AVHYIEFSNT 101 HTGNAVDLDGAFQGGGIKPA AAACASGYRT EFVSAFCQTY AYFVEQFGRE 151 RARTDARGIG FDDAQNIIQHLRTYARACRS CARQTVGRGN EGISAVVDVQ 201 QRTLRAFKQQ FFAVFVFLVQ HAGHVGNHRRNARRDFFDNR HHVFRFNRLG 251 IVQMLQLDIV IGKDGIQFFT QFXRMQQIGG ANGAACHFVFVGRADAAAGR 301 ADFAFAAXIF AGLVERDVVR QDQRAGRRDF QTAFDVFHAC RVQLVDFAQQ351 GFGGDDNART DEAVQTFMQD AARNQAQNGF FAADNQGMAR IVAALEAHHA 401AGFFRQPVND FTFTLVAPLC ADXYNIFSHS HITYRY*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 904 shows 90.4% identity over a 436 aa overlap with a predicted ORF(ORF 904.ng) from N. gonorrhoeae:

m904/g904         10        20        30        40        50        60m904.pep MMQHNRFFSVGAGGDDGDRRAADFFNPFQICFGVFGQCAVVLHAESGFAPAGHGFVNRLA||||||||:||||||||||||||||||||||||:  ||:|::||:| |||||||||||:| g904MMQHNRFFAVGAGGDDGDRRAADFFNPFQICFGIGRQCVVAFHADSRFAPAGHGFVNRFA        10        20        30        40        50        60        70        80        90       100       110       120 m904.pepGFHRIGTARQDVGFAAVGQFIADADIDGFNAVHYIEFSNTHTGNAVDLDGAFQGGGIKPA||||| ||||||||||: ||:||||||||||||||||:|:|||||||||||||||||||| g904GFHRIRTARQDVGFAAAWQFVADADIDGFNAVHYIEFGNAHTGNAVDLDGAFQGGGIKPA        70        80        90       100       110       120       130       140       150       160       170       180 m904.pepAAACASGYRTEFVSAFCQTYAYFVEQFGRERARTDARGIGFDDAQNIIQHLRTYARACRS||| |:|||||||||: || |||||||||||||||||||||||||||||||||||||||| p904AAARAAGYRTEFVSALRQTCAYFVEQFGRERARTDARGIGFDDAQNIIQHLRTYARACRS       130       140       150       160       170       180       190       200       210       220       230       240 m904.pepCARQTVGRGNEGISAVVDVQQRTLRAFKQQFFAVFVFLVQHAGHVGNHRRNARRDFFDNR | :||||||||:||||||||||||||||||||||||:|||||||||||||||||||||| p904RAGETVGRGNEGVSAVVDVQQRTLRAFKQQFFAVFVFFVQHAGHVGNHRRNARRDFFDNR       190       200       210       220       230       240       250       260       270       280       290       300 m904.pepHHVFRFNRLGIVQMLQLDIVIGKDGIQFFTQFXRMQQIGGANGAACHFVFVGRADAAAGR|||||||| |::|:|:||:||||||||||||| ||||||||||||||||||||||||||| p904HHVFRFNRSGVMQVLELDVVIGKDGIQFFTQFFRMQQIGGANGAACHFVFVGRADAAAGR       250       260       270       280       290       300       310       320       330       340       350       360 m904.pepADFAFAARIFAGLVERDVVRQDQRAGRRDFQTAFDVFHACRVQLVDFAQQGFGGDDNART|||||||| |||||||||||||||||||||||||||||||||||||||||||||:||||| p904ADFAFAARCFAGLVERDVVRQDQRAGRRDFQTAFDVFHACRVQLVDFAQQGFGGNDNART       310       320       330       340       350       360       370       380       390       400       410       420 m904.pepDEAVQTFMQDAARNQAQNGFFAADNQGMARIVAALEAHHAAGFFRQPVNDFTFTLVAPLC|||:|:|:||:|||||||||||||:||||||||||||| ||||||||||||||||||||| p904DEAIQSFVQDTARNQAQNGFFAADDQGMARIVAALEAHDAAGFFRQPVNDFTFTLVAPLC       370       380       390       400       410       420        430m904.pep ADXYNIFSHSHITYRYX || |||||||||||||| p904 ADYYNIFSHSHITYRYX       430The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2725>:

a904.seq 1 ATGATGCAGC ACAATCGTTT CTTCGCGGTC GGGGCCGGTG GAGACGATGG 51CGACCGGCGC ACCGCAGACT TCTTCAATCC GTTTCAAATA TGCTTTGGCA 101TTGGCAGGTA ATGCGTCGTA GCTTTTCACG CCGAAAGTGG ATTCGCTCCA 151ACCGGGCATG GTTTCGTAAA TCGGCTTGCA GGCTTCTACC GCATCAGAGC 201CGCAAGGCAG GATGTCGGTT TTGCCGCCGT CGGGCAATTC GTAGCCGACG 251CAGATATTGA TGGTTTCAAC GCCGTCCATT ACATCGAGTT TGGTAATACA 301CATACCGGAA ATGCCGTTGA TTTGGATGGA GCGTTTCAGG GCGGCGGCAT 351CAAACCAGCC GCAGCGGCGT GCGCGTCCGG TTACCGAACC GAATTCGTGT 401CCGCGTTCTG CCAAACCTGC TCCGACTTCG TCGAACAATT CGGTCGGGAA 451CGGGCCCGAA CCGACGCGCG TGGTATAGGC TTTGACGATG CCCAAAACAT 501AATCCAGCAT TTGAGGGCCT ACGCCCGCGC CTGCCGAAGC CGCGCCGGCG 551AGGCAGTTGG ACGAAGTAAC GAAGGGGTAA GTGCCGTAGT CGATGTCCAA 601CAACGCACCT TGCGCGCCTT CAAACAGCAG TTTTTCGCCG TTTTTGTTTT 651TTTCGTTCAA CACGCGGGAC ACGTCGGTAA TCATCGGCGT AATGCGCGGC 701GCGACTTTTT CGATAACCGC CATCACGTCT TCCGCTTTCA CCGACTCGGC 751ATTGTGCAGA TGTTGCAGTT GGACGTTGTA ATAAGCAAAG ACGGCATCCA 801GTTTTTCACG CAGTTTTTCA GGATGCAGCA AATCGGCGGC GCGAATGGCG 851CGGCGTGCCA CTTTGTCTTC GTAGGCAGGG CCGATGCCGC GGCCGGTCGT 901GCCGATTTTG CCTTTGCCGC GCGATGCTTC TCGGGCTTGG TCGAGCGCGA 951TGTGATAAGG CAGGATCAGC GGGCAGGTCG GCGCGATTTT CAGACGGCCT 1001TCGACGTTTT TCACGCCTGC CGCGTTCAAC TCGTCGATTT CGCCCAACAG 1051GGCTTCGGGG GAGACGACAA CGCCCGAACC GATGAAGCAG TCCAGACTTT 1101CATGCAGGAT GCCGCTCGGA ATCAGGCGCA AAATGGTTTT TTTGCCGCCG 1151ACAACCAAGG TATGACCCGC ATTGTGGCCG CCTTGGAAGC GCACCACGCC 1201TCCGGCTTCT TCCGCCAGCC AGTCAACGAT TTTACCTTTA CCCTCGTCGC 1251CCCACTGTGC GCCGATTACT ACAACATTTT TAGCCATAGC CATATAACCT 1301 .TCGATATTA AThis corresponds to the amino acid sequence <SEQ ID 2726; ORF 904.a>:

a904.pep 1 MMQHNRFFAV GAGGDDGDRR TADFFNPFQI CFGIGR*CVV AFHAESGFAP 51TGHGFVNRLA GFYRIRAARQ DVGFAAVGQF VADADIDGFN AVHYIEFGNT 101HTGNAVDLDG AFQGGGIKPA AAACASGYRT EFVSAFCQTC SDFVEQFGRE 151RARTDARGIG FDDAQNIIQH LRAYARACRS RAGEAVGRSN EGVSAVVDVQ 201QRTLRAFKQQ FFAVFVFFVQ HAGHVGNHRR NARRDFFDNR HHVFRFHRLG 251IVQMLQLDVV ISKDGIQFFT QFFRMQQIGG ANGAACHFVF VGRADAAAGR 301ADFAFAARCF SGLVERDVIR QDQRAGRRDF QTAFDVFHAC RVQLVDFAQQ 351GFGGDDNART DEAVQTFMQD AARNQAQNGF FAADNQGMTR IVAALEAHHA 401SGFFRQPVND FTFTLVAPLC ADYYNIFSHS HITXRY* m904/a90491.3% identity in 436 aa overlap        10        20        30        40        50        60 m904.pepMMQHNRFFSVGAGGDDGDRRAADFFNPFQICFGVFGQCAVVLHAESGFAPAGHGFVNRLA||||||||:|||||||||||:||||||||||||:   |:|::||||||||:||||||||| a904MMQHNRFFAVGAGGDDGDRRTADFFNPFQICFGIGRXCVVAFHAESGFAPTGHGFVNRLA        10        20        30        40        50        60        70        80        90       100       110       120 m904.pepGFHRIGTARQDVGFAAVGQFIADADIDGFNAVHYIEFSNTHTGNAVDLDGAFQGGGIKPA ||:||:|||||||||||||:||||||||||||||||:|||||||||||||||||||||| a904GFYRIRAARQDVGFAAVGQFVADADIDGFNAVHYIEFGNTHTGNAVDLDGAFQGGGIKPA        70        80        90       100       110       120       130       140       150       160       170       180 m904.pepAAACASGYRTEFVSAFCQTYAYFVEQFGRERARTDARGIGFDDAQNIIQHLRTYARACRS||||||||||||||||||| : ||||||||||||||||||||||||||||||:||||||| a904AAACASGYRTEFVSAFCQTCSDFVEQFGRERARTDARGIGFDDAQNIIQHLRAYARACRS       130       140       150       160       170       180       190       200       210       220       230       240 m904.pepCARQTVGRGNEGISAVVDVQQRTLRAFKQQFFAVFVFLVQHAGHVGNHRRNARRDFFDNR  |::|||:|||:||||||||||||||||||||||||:|||||||||||||||||||||| a904RAGEAVGRSNEGVSAVVDVQQRTLRAFKQQFFAVFVFFVQHAGHVGNHRRNARRDFFDNR       190       200       210       220       230       240       250       260       270       280       290       300 m904.pepHHVFRFNRLGIVQMLQLDIVIGKDGIQFFTQFXRMQQIGGANGAACHFVFVGRADAAAGR||||||:|||||||||||:||:|||||||||| ||||||||||||||||||||||||||| a904HHVFRFHRLGIVQMLQLDVVISKDGIQFFTQFFRMQQIGGANGAACHFVFVGRADAAAGR       250       260       270       280       290       300       310       320       330       340       350       360 m904.pepADFAFAAXIFAGLVERDVVRQDQRAGRRDFQTAFDVFHACRVQLVDFAQQGFGGDDNART ||||||| |:|||||||:||||||||||||||||||||||||||||||||||||||||| a904ADFAFAARCFSGLVERDVIRQDQRAGRRDFQTAFDVFHACRVQLVDFAQQGFGGDDNART       310       320       330       340       350       360       370       380       390       400       410       420 m904.pepDEAVQTFMQDAARNQAQNGFFAADNQGMARIVAALEAHHAAGFFRQPVNDFTFTLVAPLC||||||||||||||||||||||||||||:|||||||||||:||||||||||||||||||| a904DEAVQTFMQDAARNQAQNGFFAADNQGMTRIVAALEAHHASGFFRQPVNDFTFTLVAPLC       370       380       390       400       410       420        430m904.pep ADXYNIFSHSHITYRYX || |||||||||| ||| a904 ADYYNIFSHSHITXRYX       430

g906.seq not found yet

g906.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2727>:

m906.seq 1 ATGAAATATA TCGTATCAAT CTCTCTGGCT ATGGGATTGG CTGCCTGTTC 51GTTTGGGGGA TTTAAACCAA ATCCGTGGGA CGCCGCGTCA TTTTGGGAAT 101TGAAAAATTA CGCCAATCCC TATCCGGGAT CAGCCTCGGC GGCACTTGAC 151CAATATCCAT CGAAAGCAAG ACGAAGGCAA CTGAAAGACA TGCAAGAGTG 201CGGCTATGAC CCAATAGACG GCGGAAAGTC TGAAGCAGAT GCCTGCCTGA 251GGAAAAAAGG CTGGTGTCGT AAGGGTTTCG ACCCTTATCC CGAAAACAAA 301AAATACGAAT GGCCTCGAGA AGAAGGAAAA ACAAAATGAThis corresponds to the amino acid sequence <SEQ ID 2728; ORF 906>:

m906.pep 1 MKYIVSISLA MGLAACSFGG FKPNPWDAAS FWELKNYANP YPGSASAALD 51QYPSKARRRQ LKDMQECGYD PIDGGKSEAD ACLRKKGWCR KGFDPYPENK 101KYEWPREEGK TK*The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2729>:

g907.seq (partial) 1ATGAAAAAAC CGACCGATAC CCTACCCGTC AATCTgcaAC GCCGCCGCCT 51GCTGTGTGCC GCCGGCGCGC TGTTGATCAG CCCGCTGGCG CACGCCGGCG 101CGCAACGTGA AGAAACGCtt gCCGACGATG TGGCTTCCGT GATGAGGAGT 151TCTGTCGGCA GCGTCAATCC GCCGAGGCTG GTGTTCGACA ATCCGAAAGA 201GGGCGAACGT TGGTTGTCCG CGATGTCGGC ACGTTTGGCA AGATTCGTCC 251CCGACGAGGG GGAGCGGCGC AGGCTGCTGG TCAATATCCA ATACGAAAGC 301AGCCGGGCCG GTTTGGATAC GCAGATTGTG TTGGGGCTGa ttgaagtgga 351aagcgggtac cgagctcgaa tcatatca..This corresponds to the amino acid sequence <SEQ ID 2730; ORF 907.ng>:

g907.pep (partial) 1MKKPTDTLPV NLQRRRLLCA AGALLISPLA HAGAQREETL ADDVASVMRS 51SVGSVNPPRL VFDNPKEGER WLSAMSARLA RFVPDEGERR RLLVNIQYES 101SRAGLDTQIV LGLIEVESGY RARIIS...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2731>:

m907.seq 1 ATGAGAAAAC CGACCGATAC CCTACCCGTT AATCTGCAAC GCCGCCGCCT 51GTTGTGTGCC GCCGGTGCGT TGTTGCTCAG TCCTCTGGCG CACGCCGGCG 101CGCAACGTGA GGAAACGCTT GCCGACGATG TGGCTTCCGT GATGAGGAGT 151TCTGTCGGCA GCGTCAATCC GCCGAGGCTG GTGTTTGACA ATCCGAAAGA 201GGGCGAGCGT TGGTTGTCTG CCATGTCGGC ACGTTTGGCA AGGTTCGTCC 251CCGAGGAGGA GGAGCGGCGC AGGCTGCTGG TCAATATCCA GTACGAAAGC 301AGCCGGGCCG GTTTGGATAC GCAGATTGTG TTGGGGCTGA TTGAGGTGGA 351AAGCGCGTTC CGCCAGTATG CAATCAGCGG TGTCGGCGCG CGCGGCCTGA 401TGCAGGTTAT GCCGTTkTGG AAAAACTACA TCGGCAAACC GGCGCACAAC 451CTGTTCGACA TCCGCACCAA CCTGCGTTAC GGCTGTACCA TCCTGCGCCA 501TTACCGGAAT CTTGAAAAAG GCAACATCGT CCGCGCGCTT GCCCGCTTTA 551ACGGCAGCTT GGGCAGCAAT AAATATCCGA ACGCCGTTTT GGgCGCGTGG 601CGCAACCGCT GGCAGTGGCG TTGAThis corresponds to the amino acid sequence <SEQ ID 2732; ORF 907>:

m907.pep 1 MRKPTDTLPV NLQRRRLLCA AGALLLSPLA HAGAQREETL ADDVASVMRS 51SVGSVNPPRL VFDNPKEGER WLSAMSARLA RFVPEEEERR RLLVNIQYES 101SRAGLDTQIV LGLIEVESAF RQYAISGVGA RGLMQVMPXW KNYIGKPAHN 151LFDIRTNLRY GCTILRHYRN LEKGNIVRAL ARFNGSLGSN KYPNAVLGAW 201 RNRWQWR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 907 shows 92.9% identity over a 126 aa overlap with a predicted ORF(ORF 907.ng) from N. gonorrhoeae:

g907/m907         10        20        30        40        50        60g907.pep MKKPTDTLPVNLQRRRLLCAAGALLISPLAHAGAQREETLADDVASVMRSSVGSVNPPRL|:|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||| m907MRKPTDTLPVNLQRRRLLCAAGALLLSPLAHAGAQREETLADDVASVMRSSVGSVNPPRL        10        20        30        40        50        60        70        80        90       100       110       120 g907.pepVFDNPKEGERWLSAMSARLARFVPDEGERRRLLVNIQYESSRAGLDTQIVLGLIEVESGY||||||||||||||||||||||||:| |||||||||||||||||||||||||||||||: : m907VFDNPKEGERWLSAMSARLARFVPEEEERRRLLVNIQYESSRAGLDTQIVLGLIEVESAF        70        80        90       100       110       120 g907.pepRARIIS |   || m907RQYAISGVGARGLMQVMPXWKNYIGKPAHNLFDIRTNLRYGCTILRHYRNLEKGNIVRAL       130       140       150       160       170       180The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2733>:

a907.seq 1 ATGAAAAAAC CGACCGATAC CCTACCCGTC AATCTGCAAC GCCGCCGCCT 51ATTGTGTGCT GCCGGCGCGC TGTTGCTCAG CCCGCTGGCA CAAGCCGGCG 101CGCAACGTGA AGAAACGCTT GCCGACGATG TGGCTTCCGT GATGAGGAGC 151TCTGTCGGCA GCATAAATCC GCCGAGGCTG GTGTTCGACA ATCCGAAAGA 201GGGCGAGCGT TGGCTGTCCG CGATGTCTGC TCGGTTGGCA AGGTTCGTCC 251CCGATGAGGA GGAGCGGCGC AGGCTGCTGG TCAATATCCA GTACGAAAGC 301AGCCGGGCCG GTTTGGATAC GCAGATTGTG TTGGGGCTGA TTGAGGTGGA 351AAGCGCGTTC CGCCAGTATG CAATCAGCGG TGTCGGCGCG CGCGGCCTGA 401TGCAGGTTAT GCCGTTTTGG AAAAACTACA TCGGCAAACC GGCGCACAAC 451CTGTTCGACA TCCGCACCAA CCTGCGTTAC GGCTGTACCA TCCTGCGCCA 501TTACCGGAAT CTTGAAAAAG GCAACATCGT CCGCGCACTC GCCCGTTTTA 551ACGGTAGCCT CGGCAGCAAT AAATATCCGA ACGCCGTTTT GGGCGCGTGG 601CGCAACCGCT GGCAGTGGCG TTGAThis corresponds to the amino acid sequence <SEQ ID 2734; ORF 907.a>:

a907.pep 1 MKKPTDTLPV NLQRRRLLCA AGALLLSPLA QAGAQREETL ADDVASVMRS 51SVGSINPPRL VFDNPKEGER WLSAMSARLA RFVPDEEERR RLLVNIQYES 101SRAGLDTQIV LGLIEVESAF RQYAISGVGA RGLMQVMPFW KNYIGKPAHN 151LFDIRTNLRY GCTILRHYRN LEKGNIVRAL ARFNGSLGSN KYPNAVLGAW 201 RNRWQWR*m907/a907 97.6% identity in 207 aa overlap        10        20        30        40        50        60 m907.pepMRKPTDTLPVNLQRRRLLCAAGALLLSPLAHAGAQREETLADDVASVMRSSVGSVNPPRL|:||||||||||||||||||||||||||||:|||||||||||||||||||||||:||||| a907MKKPTDTLPVNLQRRRLLCAAGALLLSPLAQAGAQREETLADDVASVMRSSVGSINPPRL        10        20        30        40        50        60        70        80        90       100       110       120 m907.pepVFDNPKEGERWLSAMSARLARFVPEEEERRRLLVNIQYESSRAGLDTQIVLGLIEVESAF||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||| a907VFDNPKEGERWLSAMSARLARFVPDEEERRRLLVNIQYESSRAGLDTQIVLGLIEVESAF        70        80        90       100       110       120       130       140       150       160       170       180 m907.pepRQYAISGVGARGLMQVMPXWKNYIGKPAHNLFDIRTNLRYGCTILRHYRNLEKGNIVRAL|||||||||||||||||| ||||||||||||||||||||||||||||||||||||||||| a907RQYAISGVGARGLMQVMPFW KNYIGKPAHNLFDIRTNLRYGCTILRHYRNLEKGNIVRAL       130       140       150       160       170       180       190       200 m907.pep ARFNGSLGSNKYPNAVLGAWRNRWQWRX|||||||||||||||||||||||||||| a907 ARFNGSLGSNKYPNAVLGAWRNRWQWRX       190       200The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2735>:

g908.seq 1 ATGAG.AAAA GCCGTCTAAG CCGGTATAAA CAAAATAAAC TCATTGGGCT 51ATTTGTCGCA GGTGTAACTG CAAGAACAGC GGCAGAGTTG GTAGGCATTA 101ATAAAAATAC CGCAGCCTAT GATTTTCATC GTTTACGATG ACTGATTTAT 151CAAAACGGTC CGCATTTAGA AATGTTTGAT GGCGAAGTAG AAGCAGATGA 201AAGTTATTTT GGCGGACAAC GCAAAGGCAA ACGCGGTCGC GGTGCTGCCG 251GTAAAGTCGC CGTATTCGGT CTTTTGAAGC GAAATGGTAA GGTTTATACG 301GTTACAGTAC CGAATACTCA AACCGCTACT TTATTTCCTA TTATCCGTGA 351acaagtgaaa cctgacagta ttgtttatac ggattgttat CgTAGCTATG 401ATGTATTAGA Tgtgagcgaa tttagccatT TTagcttcgc tgaaacttcg 451ttttcgtaTC AATCACAGCA CACATTTTGC CGAACGACAA AACCATATTA 501 AThis corresponds to the amino acid sequence <SEQ ID 2736; ORF 908.ng>:

g908.pep 1 MXKSRLSRYK QNKLIGLFVA GVTARTAAEL VGINKNTAAY DFHRLR*LIY 51QNGPHLEMFD GEVEADESYF GGQRKGKRGR GAAGKVAVFG LLKRNGKVYT 101VTVPNTQTAT LFPIIREQVK PDSIVYTDCY RSYDVLDVSE FSHFSFAETS 151FSYQSQHTFC RTTKPY*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2737>:

m908.seq 1 ATGAGAAAAA GTCGTCTAAG CCAGTATAAA CAAAmTAAAC TCATTGAACT 51GTTTGTCACA GGTGTAACTG CAAGAACGGC AGCAGAGTTA GTAGGCGTTA 101ATAAAAATAC CGCAGCCTAT TATTTTCATC GTTTACGATT ACTTATTTAT 151CAAAACAGTC CGCATTTGGA AATGTTTGAT GGCGAAGTAG AAGCAGATGA 201AAGTTATTTT GGCGGACAAC GCAAAGGCAA ACGCGGTCGC GGTGCTGCCG 251GTAAAGTCGC CGTATTCGGT CTTTTGAAGC GAAATGGTAA GGTTTATACG 301GTTACAGTAC CGAATACTCA AACCGCTACT TTATTTCCTA TTATCCGTGA 351ACAAGTGAAA CCTGACAGCA TTTTTTATAC GGATTGTTAT CGTAGCTATG 401ATGTATTAGA TGTGCGCGAA TTTAGCCATT TTAGCTTCGC TGAAACTTCG 451TTTTCGTATC AATCACAGCA CACATTTTGC CGAACGACAA AACCATATTA 501 AThis corresponds to the amino acid sequence <SEQ ID 2738; ORF 908>:

m908.pep 1 MRKSRLSQYK QXKLIELFVT GVTARTAAEL VGVNKNTAAY YFHRLRLLIY 51QNSPHLEMFD GEVEADESYF GGQRKGKRGR GAAGKVAVFG LLKRNGKVYT 101VTVPNTQTAT LFPIIREQVK PDSIFYTDCY RSYDVLDVRE FSHFSFAETS 151FSYQSQHTFC RTTKPY*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 908 shows 93.4% identity over a 166 aa overlap with a predicted ORF(ORF 908.ng) from N. gonorrhoeae:

908/m908         10        20        30        40        50        60g908.pep MXKSRLSRYKQNKLIGLFVAGVTARTAAELVGINKNTAAYDFHRLRXLIYQNGPHLEMFD|10 |||||:||| ||| |||:||||||||||||:||||||| ||||| |||||:||||||| m908MRKSRLSQYKQXKLIELFVTGVTARTAAELVGVNKNTAAYYFHRLRLLIYQNSPHLEMFD        10        20        30        40        50        60        70        80        90       100       110       120 g908.pepGEVEADESYFGGQRKGKRGRGAAGKVAVFGLLKRNGKVYTVTVPNTQTATLFPIIREQVK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m908GEVEADESYFGGQRKGKRGRGAAGKVAVFGLLKRNGKVYTVTVPNTQTATLFPIIREQVK        70        80        90       100       110       120       130       140       150       160 g908.pepPDSIVYTDCYRSYDVLDVSEFSHFSFAETSFSYQSQHTFCRTTKPYX|||| ||||||||||||| |||||||||||||||||||||||||||| m908PDSIFYTDCYRSYDVLDVREFSHFSFAETSFSYQSQHTFCRTTKPYX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2739>:

a908.seq 1 ATGAGAAAAA GTCGTCTAAG CCAGTATAAA CAAAATAAAC TCATTGAGCT 51ATTTGTCGCA GGTGTAACTG CAAGAACGGC AGCAGAGTTA GTAGGCGTTA 101 ATAAAAATACCGCAGCCTAT TATTTTCATC GTTTACGATT ACTTATTTAT 151 CAAAACAGTC CGCATTTGGAAATGTTTGAT GGCGAAGTAG AAGCAGATGA 201 AAGTTATTTT GGCGGACAAC GCAAAGGCAAACGCGGTCGC GGTGCTGCCG 251 GTAAAGTCGC CGTATTCGGT CTTTTGAAGC GAAATGGTAAGGTTTATACG 301 GTTACAGTAC CGAATACTCA AACCGCTACT TTATTTCCTA TTATCCGTGA351 ACAAGTGAAA CCTGACAGCA TTGTTTATAC GGATTGTTAT CGTAGCTATG 401ATGTATTAGA TGTGCGCGAA TTTAGCCATT TTAGCTTCGC TGAAACTTCG 451 TTTTCGTATCAATCACAGCA CACATTTTGC CGAACGACAA AACCATATTA 501 AThis corresponds to the amino acid sequence <SEQ ID 2740; ORF 908.a>:

a908.pep 1 MRKSRLSQYK QNKLIELFVA GVTARTAAEL VGVNKNTAAY YFHRLRLLIY 51QNSPHLEMFD GEVEADESYF GGQRKGKRGR GAAGKVAVFG LLKRNGKVYT 101 VTVPNTQTATLFPIIREQVK PDSIVYTDCY RSYDVLDVRE FSHFSFAETS 151 FSYQSQHTFC RTTKPY*m908/a908 98.2% identity in 166 aa overlap        10        20        30        40        50        60 m908.pepMRKSRLSQYKQXKLIELFVTGVTARTAAELVGVNKNTAAYYFHRLRLLIYQNSPHLEMFD||||||||||| |||||||:|||||||||||||||||||||||||||||||||||||||| a908MRKSRLSQYKQNKLIELFVAGVTARTAAELVGVNKNTAAYYFHRLRLLIYQNSPHLEMFD        10        20        30        40        50        60        70        80        90       100       110       120 m908.pepGEVEADESYFGGQRKGKRGRGAAGKVAVFGLLKRNGKVYTVTVPNTQTATLFPIIREQVK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a908GEVEADESYFGGQRKGKRGRGAAGKVAVFGLLKRNGKVYTVTVPNTQTATLFPIIREQVK        70        80        90       100       110       120       130       140       150       160 m908.pepPDSIFYTDCYRSYDVLDVREFSHFSFAETSFSYQSQHTFCRTTKPYX|||| |||||||||||||||||||||||||||||||||||||||||| a908PDSIVYTDCYRSYDVLDVREFSHFSFAETSFSYQSQHTFCRTTKPYX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2741>:

g909.seq (partial) 1 atgcgtaaaa ccgtacttat cCTgaccatc tccgccgcccttttgtcggg 51 ctgcacatgG gaaacttatc aagacggcag cggcaaaacc gccgtccgtg 101caaaatgttc caccggcacg ccgctgtgtt ggcaagacgg gcgcggctcg 151 aaaaaggtggactgcgacga gtacggtggc gaacgccggg ccgtgttgcg 201 caaccaaaag cgggggaagcccgcgacgag gagagccgca acgctgggga 251 aaccgagttt ccgggcgagg gacgggggggggcgggtgaa cagggcagaa 301 acgggggagg ggaagcgatc ggcgagg..This corresponds to the amino acid sequence <SEQ ID 2742; ORF 909.ng>:

g909.pep (partial) 1 MRKTVLILTI SAALLSGCTW ETYQDGSGKT AVRAKCSTGTPLCWQDGRGS 51 KKVDCDEYGG ERRAVLRNQK RGKPATRRAA TLGKPSFRAR DGGGRVNRAE 101TGEGKRSAR..The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2743>:

m909.seq 1 ATGCGTAAAA CCTTCCTCTT CCTGACCGCT GCCGCCGCCC TTTTGTCGGG 51CTGCGCGTGG GAAACTTATC AAGACGGCAA CGGCAAGACC GCCGTCCGTC 101 AAAAATATCCCGCCGGCACG CCCGTTTATT ACCAAGACGG CAGCTACTCG 151 AAAAATATGA ACTACAACCAATACCGTCCC GAACGCCATG CCGTGTTACC 201 CAATCAAACC GGCAACAACG CCGACGAAGAGCATCGCCAA CACTGGCAAA 251 AACCAAAGTT TCAAAACCGA TAAThis corresponds to the amino acid sequence <SEQ ID 2744; ORF 909>:

m909.pep 1 MRKTFLFLTA AAALLSGCAW ETYQDGNGKT AVRQKYPAGT PVYYQDGSYS 51KNMNYNQYRP ERHAVLPNQT GNNADEEHRQ HWQKPKFQNR *Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 909 shows 53.3% identity over a 90 aa overlap with a predicted ORF(ORF 909.ng) from N. gonorrhoeae:

m909/g909         10        20        30        40        50        60m909.pep MRKTFLFLTAAAALLSGCAWETYQDGNGKTAVRQKYPAGTPVYYQDGSYSKNMNYNQYRP|||| |:|| :|||||||:|||||||:|||||| |  :|||: :|||  ||::: ::| g909MRKTVLILTISAALLSGCTWETYQDGSGKTAVRAKCSTGTPLCWQDGRGSKKVDCDEYGG        10        20        30        40        50        60        70        80        90 m909.pep ERHAVLPNQTGNNADEEHRQHWQKPKFQNRX||:||| ||  ::   ::     ||:|: | g909ERRAVLRNQKRGKPATRRAATLGKPSFRARDGGGRVNRAETGEGKRSAR        70        80        90       100The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2745>:

a909.seq 1 ATGCGTAAAA CCTTCCTTAT CCTGATGACT GCCGCCGCCC TTTTGTCGGG 51CTGCGCGTGG GAAACTTATC AAGACGGCAA CGGCAAGACC GCCGTCCGTC 101 AAAAATATCCCGCCGGCACG CCCGTTTATT ACCAAGACGG CAGCTACTCG 151 AAAAATATGA ACTACAACCAATACCGTCCC GAACGCCATG CCGTGTTACC 201 CAACCAAACC GGCAACAACG CCGACGAAGAGCATCGCCAA CACTGGCAAA 251 AGCCCAAATT TCAAAACCGA TAAThis corresponds to the amino acid sequence <SEQ ID 2746; ORF 909.a>:

a909.pep 1 MRKTFLILMT AAALLSGCAW ETYQDGNGKT AVRQKYPAGT PVYYQDGSYS 51KNMNYNQYRP ERHAVLPNQT GNNADEEHRQ HWQKPKFQNR * m909/a909 96.7% identityin 90 aa overlap        10        20        30        40        50        60 m909.pepMRKTFLFLTAAAALLSGCAWETYQDGNGKTAVRQKYPAGTPVYYQDGSYSKNMNYNQYRP||||||:| :|||||||||||||||||||||||||||||||||||||||||||||||||| a909MRKTFLILMTAAALLSGCAWETYQDGNGKTAVRQKYPAGTPVYYQDGSYSKNMNYNQYRP        10        20        30        40        50        60        70        80        90 m909.pep ERHAVLPNQTGNNADEEHRQHWQKPKFQNRX||||||||||||||||||||||||||||||| a909 ERHAVLPNQTGNNADEEHRQHWQKPKFQNRX        70        80        90The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2747>:

g910.seq 1 ATGAAAAAAC TGTTATTGGC CGCCGTTGTT TCCCTAAATG CCGCAACCGC 51ATTTGCCGGC GACTCTGCCG AGCGTCAGAT TTACGGCGAT CCCCATTTTG 101 AACAAAACCGCACAAAAGCC GTGAAAATGT TGGAACAGCG CGGTTATCAG 151 GTTTACGATG TCGATGCCGACGACTACTGG GGCAAACCTG TTTTGGAAGT 201 GGAAGCCTAT AAAGACGGCC GCGAATACGACATCGTGTTG TCTTACCCCG 251 ACCTGAAAAT CATCAAAGAG CAGCTCGATC GCTGAThis corresponds to the amino acid sequence <SEQ ID 2748; ORF 910.ng>:

g910.pep 1 MKKLLLAAVV SLNAATAFAG DSAERQIYGD PHFEQNRTKA VKMLEQRGYQ 51VYDVDADDYW GKPVLEVEAY KDGREYDIVL SYPDLKIIKE QLDR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2749>:

m910.seq 1 ATGAAAAAAC TGTTATTGGC TGCCGTTGTT TCTCTGAGTG CCGCTGCCGC 51ATTTGCCGGC GACTCTGCCG AGCGTCAGAT TTACGGCGAT CCCCATTTTG 101 AACAAAACCGCACAAAAGCT GTGAAAATGT TGGAGCAGCG CGGTTATCAG 151 GTTTACGATG TCGATGCCGACGACCATTGG GGTAAGCCTG TGCTGGAAGT 201 GGAAGCCTAT AAAGACGGCC GCGAATACGACATCGTGTTG TCTTACCCCG 251 ACCTGAAAAT CATCAAAGAG CAGCTCGATC GCTGAThis corresponds to the amino acid sequence <SEQ ID 2750; ORF 910>:

m910.pep 1 MKKLLLAAVV SLSAAAAFAG DSAERQIYGD PHFEQNRTKA VKMLEQRGYQ 51VYDVDADDHW GKPVLEVEAY KDGREYDIVL SYPDLKIIKE QLDR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 910 shows 96.8% identity over a 94 aa overlap with a predicted ORF(ORF 910.ng) from N. gonorrhoeae:

g910/m910         10        20        30        40        50        60g910.pep MKKLLLAAVVSLNAATAFAGDSAERQIYGDPHFEQNRTKAVKMLEQRGYQVYDVDADDYW||||||||||||:||:||||||||||||||||||||||||||||||||||||||||||:| m910MKKLLLAAVVSLSAAAAFAGDSAERQIYGDPHFEQNRTKAVKMLEQRGYQVYDVDADDHW        10        20        30        40        50        60        70        80        90 g910.pepGKPVLEVEAYKDGREYDIVLSYPDLKIIKEQLDRX |||||||||||||||||||||||||||||||||||m910 GKPVLEVEAYKDGREYDIVLSYPDLKIIKEQLDRX         70        80        90The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2751>:

a910.seq 1 ATGAAAAAAC TGTTATTGGT CGCCGTTGTT TCCTTGAGTG CCGCAACCGC 51ATTTGCCGGC GACTCTGCCG AGCGTCAGAT TTACGGCGAT CCCTATTTTG 101AACAAAACCG CACAAAAGCC GTGAAAATGT TGGAACAGCG CGGTTATCAG 151GTTCACGATG TCGATGCCGA CGACCATTGG GGCAAACCTG TTTTGGAAGT 201GGAAGCCTAT AAAGACGGCC GCGAATACGA CATTGTGTTG TCTTACCCCG 251ACCTGAAAAT CATCAAAGAG CAGCTCGATC GCTGAThis corresponds to the amino acid sequence <SEQ ID 2752; ORF 910.a>:

a910.pep 1 MKKLLLVAVV SLSAATAFAG DSAERQIYGD PYFEQNRTKA VKMLEQRGYQ 51VHDVDADDHW GKPVLEVEAY KDGREYDIVL SYPDLKIIKE QLDR* m910/a91095.7% identity in 94 aa overlap        10        20        30        40        50        60 m910.pepMKKLLLAAVVSLSAAAAFAGDSAERQIYGDPHFEQNRTKAVKMLEQRGYQVYDVDADDHW||||||:||||||||:|||||||||||||||:|||||||||||||||||||:|||||||| a910MKKLLLVAVVSLSAATAFAGDSAERQIYGDPYFEQNRTKAVKMLEQRGYQVHDVDADDHW        10        20        30        40        50        60        70        80        90 m910.pepGKPVLEVEAYKDGREYDIVLSYPDLKIIKEQLDRX |||||||||||||||||||||||||||||||||||a910 GKPVLEVEAYKDGREYDIVLSYPDLKIIKEQLDRX         70        80        90The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2753>:

g911.seq 1 ATGAAAAAGA ACATATTGGA ATTTTGGGTC GGACTGTTCG TCTTGATCGG 51CGCGGCGGCG GTTGCCTTTC TCGCTTTCCG CGTGGCGGGC GGCGCGGCGT 101TCGGCGGTTC GGACAAAACT TACGCCGTTT ATGCCGATTT CGGCGACATC 151GGCGGTTTGA AGGTCAATGC CCCCGTCAAA TCCGCAGGCG TATTGGTCGG 201GCGCGTCGGC GCTATCGGGC TTGACCCGAA ATCCTATCAG GCGAGGGTGC 251GCCTTGATTT GGACGGCAAG TATCAGTTCA GCAGTGACGT TTCCGCGCAA 301ATCCTGACTT CGGGACTTTT GGGCGAACAG TACATCGGGC TGCAGCAGGG 351CGGCGATACG GAAAACCTTG CTGCCGGCGA CACCATCTCC GTAACCAGTT 401CTGCAATGGT TCTGGAAAAC CTGATCGGTA AATTCATGAC CAGCTTCGCC 451GAGAAAAACG CTGAGGGCGG CAATGCGGAA AAAGCCGcag aAtaaThis corresponds to the amino acid sequence <SEQ ID 2754; ORF 911.ng>:

g911.pep 1 MKKNILEFWV GLFVLIGAAA VAFLAFRVAG GAAFGGSDKT YAVYADFGDI 51GGLKVNAPVK SAGVLVGRVG AIGLDPKSYQ ARVRLDLDGK YQFSSDVSAQ 101ILTSGLLGEQ YIGLQQGGDT ENLAAGDTIS VTSSAMVLEN LIGKFMTSFA 151EKNAEGGNAE KAAE*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2755>:

m911.seq 1 ATGAAGAAGA ACATATTGGA ATTTTGGGTC GGACTGTTCG TCCTGATTGG 51CGCGGCGGCG GTTGCCTTTC TCGCTTTCCG CGTGGCCGGC GGTGCGGCGT 101TCGGCGGTTC GGACAAAACT TACGCCGTTT ATGCCGATTT CGGCGACATC 151GGCGGTTTGA AGGTCAATGC CCCCGTCAAA TCCGCAGGCG TATTGGTCGG 201GCGCGTCGGC GCTATCGGAC TTGACCCGAA ATCCTATCAG GCGAGGGTGC 251GCCTCGATTT GGACGGCAAG TATCAGTTCA GCAGCGACGT TTCCGCGCAA 301ATCCTGACTT CGGGACTTTT GGGCGAGCAG TACATCGGGC TGCAGCAGGG 351CGGCGACACG GAAAACCTTG CTGCCGGCGA CACCATCTCC GTAACCAGTT 401CTGCAATGGT TCTGGAAAAC CTTATCGGCA AATTCATGAC GAGTTTTGCC 451GAGAAAAATG CCGACGGCGG CAATGCGGAA AAAGCCGCCG AATAAThis corresponds to the amino acid sequence <SEQ ID 2756; ORF 911>:

m911.pep 1 MKKNILEFWV GLFVLIGAAA VAFLAFRVAG GAAFGGSDKT YAVYADFGDI 51GGLKVNAPVK SAGVLVGRVG AIGLDPKSYQ ARVRLDLDGK YQFSSDVSAQ 101ILTSGLLGEQ YIGLQQGGDT ENLAAGDTIS VTSSAMVLEN LIGKFMTSFA 151EKNADGGNAE KAAE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 911 shows 99.4% identity over a 164 aa overlap with a predicted ORF(ORF 911.ng) from N. gonorrhoeae:

g911/m911         10        20        30        40        50        60g911.pep MKKNILEFWVGLFVLIGAAAVAFLAFRVAGGAAFGGSDKTYAVYADFGDIGGLKVNAPVK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m911MKKNILEFWVGLFVLIGAAAVAFLAFRVAGGAAFGGSDKTYAVYADFGDIGGLKVNAPVK        10        20        30        40        50        60        70        80        90       100       110       120 g911.pepSAGVLVGRVGAIGLDPKSYQARVRLDLDGKYQFSSDVSAQILTSGLLGEQYIGLQQGGDT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m911SAGVLVGRVGAIGLDPKSYQARVRLDLDGKYQFSSDVSAQILTSGLLGEQYIGLQQGGDT        70        80        90       100       110       120       130       140       150       160 g911.pepENLAAGDTISVTSSAMVLENLIGKFMTSFAEKNAEGGNAEKAAEX||||||||||||||||||||||||||||||||||:|||||||||| m911ENLAAGDTISVISSAMVLENLIGKFMTSFAEKNADGGNAEKAAEX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2757>:

a911.seq 1 ATGAAAAAGA ACATATTGGA ATTTTGGGTC GGACTGTTCG TCCTGATTGG 51CGCGGCGGCG GTTGCCTTTC TCGCTTTCCG CGTGGCCGGC GGTGCGGCGT 101TCGGCGGTTC GGACAAAACT TACGCCGTTT ATGCCGATTT CGGCGACATC 151GGCGGTTTGA AGGTCAATGC CCCCGTCAAA TCCGCAGGCG TATTGGTCGG 201GCGCGTCGGC GCTATCGGAC TTGACCCGAA ATCCTATCAG GCGAGGGTGC 251GCCTCGATTT GGACGGCAAG TATCAGTTCA GCAGCGACGT TTCCGCGCAA 301ATCCTGACTT CGGGACTTTT GGGCGAGCAG TACATCGGGC TGCAGCAGGG 351CGGCGACACG GAAAACCTTG CTGCCGGCGA CACCATCTCC GTAACCAGTT 401CTGCAATGGT TCTGGAAAAC CTTATCGGCA AATTCATGAC GAGTTTTGCC 451GAGAAAAATG CCGACGGCGG CAATGCGGAA AAAGCCGCCG AATAAThis corresponds to the amino acid sequence <SEQ ID 2758; ORF 911.a>:

a911.pep 1 MKKNILEFWV GLFVLIGAAA VAFLAFRVAG GAAFGGSDKT YAVYADFGDI 51GGLKVNAPVK SAGVLVGRVG AIGLDPKSYQ ARVRLDLDGK YQFSSDVSAQ 101ILTSGLLGEQ YIGLQQGGDT ENLAAGDTIS VTSSAMVLEN LIGKFMTSFA 151EKNADGGNAE KAAE* m911/a911 100.0% identity in 164 aa overlap        10        20        30        40        50        60 m911.pepMKKNILEFWVGLFVLIGAAAVAFLAFRVAGGAAFGGSDKTYAVYADFGDIGGLKVNAPVK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a911MKKNILEFWVGLFVLIGAAAVAFLAFRVAGGAAFGGSDKTYAVYADFGDIGGLKVNAPVK        10        20        30        40        50        60        70        80        90       100       110       120 m911.pepSAGVLVGRVGAIGLDPKSYQARVRLDLDGKYQFSSDVSAQILTSGLLGEQYIGLQQGGDT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a911SAGVLVGRVGAIGLDPKSYQARVRLDLDGKYQFSSDVSAQILTSGLLGEQYIGLQQGGDT        70        80        90       100       110       120       130       140       150       160 m911.pepENLAAGDTISVTSSAMVLENLIGKFMTSFAEKNADGGNAEKAAEX||||||||||||||||||||||||||||||||||||||||||||| a911ENLAAGDTISVISSAMVLENLIGKFMTSFAEKNADGGNAEKAAEX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2759>:

g912.seq 1 gtgAAAAaat cctcctTcat cagcGCATTG GGCATCGgtA TTTTGAGCAT 51CGGCATGGCA TTTGCCTCCC CGGCCGACGC AGTGGGACAA ATCCGCCAAA 101ACGCCACACA GGTTTTGACC ATCCTCAAAA GCGGCGACGC GGCTTCTGCA 151CGCCCAAAAG CCGAAGCCTA TGCGGTTCCC TATTTCGATT TCCAACGTAT 201GACCGCATTG GCGGTCGGCA ACCCTTGGCG TACCGCGTCC GACGCGCAAA 251AACAAGCGTT GGCCAAAGAA TTTCAAACCC TGCTGATCCG CACCTATTCC 301GGCACGATGC TGAAATTCAA AAACGCGACC GTCAACGTCA AAGACAATCC 351CATCGTCAAT AAGGGCGGCA AGGAAATCGT CGTCCGTGCC GAAGTCGGCA 401TCCCCGGTCA GAAGCCCGTC AATATGGACT TTACCACCTA CCAAAGCGGC 451GGCAAATACC GTACCTACAA CGTCGCCATC GAAGGCACGA GCCTGGTTAC 501CGTGTACCGC AACCAATTCG GCGAAATCAT CAAAGCCAAA GGCATCGACG 551GGCTGATTGC CGAGTTGAAA GCCAAAAACG GCGGCAAATA AThis corresponds to the amino acid sequence <SEQ ID 2760; ORF 912.ng>:

g912.pep 1 VKKSSFISAL GIGILSIGMA FASPADAVGQ IRQNATQVLT ILKSGDAASA 51RPKAEAYAVP YFDFQRMTAL AVGNPWRTAS DAQKQALAKE FQTLLIRTYS 101GTMLKFKNAT VNVKDNPIVN KGGKEIVVRA EVGIPGQKPV NMDFTTYQSG 151GKYRTYNVAI EGTSLVTVYR NQFGEIIKAK GIDGLIAELK AKNGGK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2761>:

m912.seq 1 ATGAAAAAAT CCTCCCTCAT CAGCGCATTG GGCATCGGTA TTTTGAGCAT 51CGGCATGGCA TTTGCCGCCC CTGCCGACGC GGTAAGCCAA ATCCGTCAAA 101ACGCCACTCA AGTATTGAGC ATCTTAAAAA ACGGCGATGC CAACACCGCT 151CGCCAAAAAG CCGAAGCCTA TGCGATTCCC TATTTCGATT TCCAACGTAT 201GACCGCATTG GCGGTCGGCA ACCCTTGGCG CACCGCGTCC GACGCGCAAA 251AACAAGCGTT GGCCAAAGAA TTTCAAACCC TGCTGATCCG CACCTATTCC 301GGCACGATGC TGAAATTAAA AAACGCCAAC GTCAACGTCA AAGACAATCC 351CATCGTCAAT AAAGGCGGCA AAGAAATCAT CGTCCGCGCC GAAGTCGGCG 401TACCCGGGCA AAAACCCGTC AACATGGACT TCACCACCTA CCAAAGCGGC 451GGTAAATACC GTACCTACAA CGTCGCCATC GAAGGCGCGA GCCTGGTTAC 501CGTGTACCGC AACCAATTCG GCGAAATTAT CAAAGCGAAA GGCGTGGACG 551GACTGATTGC CGAGTTGAAA GCCAAAAACG GCGGCAAATA AThis corresponds to the amino acid sequence <SEQ ID 2762; ORF 912>:

m912.pep 1 MKKSSLISAL GIGILSIGMA FAAPADAVSQ IRQNATQVLS ILKNGDANTA 51RQKAEAYAIP YFDFQRMTAL AVGNPWRTAS DAQKQALAKE FQTLLIRTYS 101GTMLKLKNAN VNVKDNPIVN KGGKEIIVRA EVGVPGQKPV NMDFTTYQSG 151GKYRTYNVAI EGASLVTVYR NQFGEIIKAK GVDGLIAELK AKNGGK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 912 shows 91.8% identity over a 196 aa overlap with a predicted ORF(ORF 912.ng) from N. gonorrhoeae:

g912/m912         10        20        30        40        50        60g912.pep VKKSSFISALGIGILSIGMAFASPADAVGQIRQNATQVLTILKSGDAASARPKAEAYAVP:||||:||||||||||||||||:|||||:||||||||||:|||:||| :|| ||||||:| m912MKKSSLISALGIGILSIGMAFAAPADAVSQIRQNATQVLSILKNGDANTARQKAEAYAIP        10        20        30        40        50        60        70        80        90       100       110       120 g912.pepYFDFQRMTALAVGNPWRTASDAQKQALAKEFQTLLIRTYSGTMLKFKNATVNVKDNPIVN|||||||||||||||||||||||||||||||||||||||||||||:|||:|||||||||| m912YFDFQRMTALAVGNPWRIASDAQKQALAKEFQTLLIRTYSGTMLKLKNANVNVKDNPIVN        70        80        90       100       110       120       130       140       150       160       170       180 g912.pepKGGKEIVVRAEVGIPGQKPVNMDFTTYQSGGKYRTYNVAIEGTSLVTVYRNQFGEIIKAK||||||:||||||:||||||||||||||||||||||||||||:||||||||||||||||| m912KGGKEIIVRAEVGVPGQKPVNMDFTTYQSGGKYRTYNVAIEGASLVTVYRNQFGEIIKAK       130       140       150       160       170       180        190g912.pep GIDGLIAELKAKNGGKX |:||||||||||||||| m912 GVDGLIAELKAKNGGKX       190The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2763>:

a912.seq 1 ATGAAAAAAT CCTCCTTCAT CAGCGCATTG GGCATCGGTA TTTTGAGCAT 51CGGCATGGCA TTTGCCGCCC CTGCCGACGC GGTAAACCAA ATCCGTCAAA 101ACGCCACTCA AGTATTGAGC ATCTTAAAAA GCGGTGATGC CAACACCGCC 151CGCCAAAAAG CCGAAGCCTA TGCGATTCCC TATTTCGATT TCCAACGTAT 201GACCGCATTG GCGGTCGGCA ACCCTTGGCG CACCGCGTCC GACGCGCAAA 251AACAAGCGTT GGCCAAAGAA TTTCAAACCC TGCTGATCCG CACCTATTCC 301GGCACGATGC TGAAATTAAA AAACGCCAAC GTCAACGTCA AAGACAATCC 351CATCGTCAAT AAAGGCGGCA AAGAAATCAT CGTCCGCGCC GAAGTCGGCG 401TACCCGGGCA AAAACCCGTC AACATGGACT TCACCACCTA CCAAAGCGGC 451GGTAAATACC GTACCTACAA CGTCGCCATC GAAGGCGCGA GCCTGGTTAC 501CGTGTACCGC AACCAATTCG GCGAAATTAT CAAAGCGAAA GGCGTGGACG 551GACTGATTGC CGAGTTGAAG GCTAAAAACG GCAGCAAGTA AThis corresponds to the amino acid sequence <SEQ ID 2764; ORF 912.a>:

a912.pep 1 MKKSSFISAL GIGILSIGMA FAAPADAVNQ IRQNATQVLS ILKSGDANTA 51RQKAEAYAIP YFDFQRMTAL AVGNPWRTAS DAQKQALAKE FQTLLIRTYS 101 GTMLKLKNANVNVKDNPIVN KGGKEIIVRA EVGVPGQKPV NMDFTTYQSG 151 GKYRTYNVAI EGASLVTVYRNQFGEIIKAK GVDGLIAELK AKNGSK* m912/a912 98.0% identity in 196 aa overlap        10        20        30        40        50        60 m912.pepMKKSSLISALGIGILSIGMAFAAPADAVSQIRQNATQVLSILKNGDANTARQKAEAYAIP|||||:||||||||||||||||||||||:||||||||||||||:|||||||||||||||| a912MKKSSFISALGIGILSIGMAFAAPADAVNQIRQNATQVLSILKSGDANTARQKAEAYAIP        10        20        30        40        50        60        70        80        90       100       110       120 m912.pepYFDFQRMTALAVGNPWRTASDAQKQALAKEFQTLLIRTYSGTMLKLKNANVNVKDNPIVN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a912YFDFQRMTALAVGNPWRTASDAQKQALAKEFQTLLIRTYSGTMLKLKNANVNVKDNPIVN        70        80        90       100       110       120       130       140       150       160       170       180 m912.pepKGGKEIIVRAEVGVPGQKPVNMDFTTYQSGGKYRTYNVAIEGASLVTVYRNQFGEIIKAK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a912KGGKEIIVRAEVGVPGQKPVNMDFTTYQSGGKYRTYNVAIEGASLVTVYRNQFGEIIKAK       130       140       150       160       170       180        190m912.pep GVDGLIAELKAKNGGKX ||||||||||||||:|| a912 GVDGLIAELKAKNGSKX       190The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2765>:

g913.seq 1 atGAAAAAAA CCGCCTACGC CATCCTCCTG CTGATCGGGT TCGCTTCCGC 51CCCTGCATTT GCAGAAACCC GCCCCGCCGA CCCTTATGAA GGCTACAACC 101 GCGCCGTTTCCAAATTCAAC GACCAAGCCG ACCGCTACAT TTTCGCCCCT 151 GCCGCGCGCG GCTACCGCAAAGTTACGCCG AAACCCGTCC GCGCCGGCGT 201 GTCCAATTTT TTTAACAACC TGCGCGACGTGGTCAGTTTC GGCAGCAATA 251 TCTTGCGTTT GGAcatCAAA cgcgcAAGcg aAGACCtcgTCCGcgtcggc 301 atCAATACCA CCTTCGGTTT GGgcgGGCTC ATTGATATTG CCGGcgcGGg351 cggcgttccc gacaataaaa AcacTttgGg cgacacgttt gcctcgtGGG 401GctgGAAAaa cagcaATTAT TTCGTgttgc CCGtcttagg cccgtccacc 451 gtccgcgacgcgctcggcac gggcattacc tCTGTTTATC CGCccaagaa 501 tatcgttttc catacccctgccggacgctg GGgcacgact gCCGCTGCCG 551 CCGTcagtac gcgcgaaggc ctcctcgatttgaccgacag TCtggacgaa 601 gccgccatCG ACAAATACAG CTACACGCGc gacctctatatgAAAGTCCG 651 CGcacgGCag AccgGTGCAA CACCTGCCGA AGgtacggaa gataacatcg701 acatcgacat cgACGAATTG GTCGAAAGTG CCGAAACCGG CGCGGCAGAG 751CCCGCCGTTC ACGAAGATTC CGTATCCGAA ACACAGGCAG AAGCAGCAGG 801 GGAAGCCGAAACGCAACCTG GAACACAACC CTAAThis corresponds to the amino acid sequence <SEQ ID 2766; ORF 913.ng>:

g913.pep 1 MKKTAYAILL LIGFASAPAF AETRPADPYE GYNRAVSKFN DQADRYIFAP 51AARGYRKVTP KPVRAGVSNF FNNLRDVVSF GSNILRLDIK RASEDLVRVG 101 INTTFGLGGLIDIAGAGGVP DNKNTLGDTF ASWGWKNSNY FVLPVLGPST 151 VRDALGTGIT SVYPPKNIVFHTPAGRWGTT AAAAVSTREG LLDLTDSLDE 201 AAIDKYSYTR DLYMKVRARQ TGATPAEGTEDNIDIDIDEL VESAETGAAE 251 PAVHEDSVSE TQAEAAGEAE TQPGTQP*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2767>:

m913.seq 1 ATGAAAAAAA CCGCCTATGC CTTCCTCCTG CTGATCGGGT TCGCTTCCGC 51CCCTGCATTT GCCGAAACCC GCCCCGCCGA CCCTTATGAA GGCTACAACC 101 GCGCCGTTTTCAAATTCAAC GACCAAGCCG ACCGCTACAT TTTCGCCCCT 151 GCCGCGCGCG GCTACCGCAAAGTTGCGCCG AAACCCGTCC GCGCCGGCGT 201 GTCCAATTTT TTTAACAACC TGTGCGACGTGGTCAGCTTC GGCAGCAATA 251 TCTTGCGCTT GGACATCAAA CGCGCAAGCG AAGACCTTGTCCGCGTCGGC 301 ATCAACACCA CTTTCGGTTT GGGCGGGCTT ATCGACATCG CCGGCGCGGG351 CGGCATTCCC GACAATAAAA ACACCTTGGG CGACACGTTT GCCTCGTGGG 401GATGGAAAAA CAGCAATTAT TTCGTGTTGC CCGTCTTAGG GCCGTCCACC 451 GTCCGCGACGCGCTCGGCAC GGGTATTACC TCCGTTTATT CGCCCAAGAA 501 TATCGTCTTC CGCACCCCTGTCGGACGCTG GGGCACGACT GCCGTATCCG 551 CCGTCAGTAC GCGCGAAGGC CTgCTCGATTTGACCGACAG TCTGGACGAA 601 GCCGCCATCG ACAAATACAG CTACACGCGC GACCTCTATATGAAAGTCCG 651 TGCGCGGCAG ACCGGTGCAA CACCTGCCGA AGgTACGGAA GATAACATCG701 ACATCGACGA ATTGGTCGAA AGTGCCGAAA CCGGCGCGGC GGAAACTGCC 751GTTCAAGAAG ATTCCGTATC CGAAACACAG GCAGAAGCAG CAGGGGAAGC 801 CGAAACGCAACCTGGAACAC AACCTTAAThis corresponds to the amino acid sequence <SEQ ID 2768; ORF 913>:

m913.pep 1 MKKTAYAFLL LIGFASAPAF AETRPADPYE GYNRAVFKFN DQADRYIFAP 51AARGYRKVAP KPVRAGVSNF FNNLCDVVSF GSNILRLDIK RASEDLVRVG 101 INTTFGLGGLIDIAGAGGIP DNKNTLGDTF ASWGWKNSNY FVLPVLGPST 151 VRDALGTGIT SVYSPKNIVFRTPVGRWGTT AVSAVSTREG LLDLTDSLDE 201 AAIDKYSYTR DLYMKVRARQ TGATPAEGTEDNIDIDELVE SAETGAAETA 251 VQEDSVSETQ AEAAGEAETQ PGTQP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 913 shows 94.9% identity over a 277 aa overlap with a predicted ORF(ORF 913.ng) from N. gonorrhoeae:

g913/m913          10        20        30        40        50        60g913.pep  MKKTAYAILLLIGFASAPAFAETRPADPYEGYNRAVSKFNDQADRYIFAPAARGYRKVTP |||||||:|||||||||||||||||||||||||||| |||||||||||||||||||||:| m913 MKKTAYAFLLLIGFASAPAFAETRPADPYEGYNRAVFKFNDQADRYIFAPAARGYRKVAP         10        20        30        40        50        60         70        80        90       100       110       120 g913.pep KPVRAGVSNFFNNLRDVVSFGSNILRLDIKRASEDLVRVGINTTFGLGGLIDIAGAGGVP |||||||||||||| |||||||||||||||||||||||||||||||||||||||||||:| m913 KPVRAGVSNFFNNLCDVVSFGSNILRLDIKRASEDLVRVGINTTFGLGGLIDIAGAGGIP         70        80        90       100       110       120        130       140       150       160       170       180 g913.pep DNKNTLGDTFASWGWKNSNYFVLPVLGPSTVRDALGTGITSVYPPKNIVFHTPAGRWGTT ||||||||||||||||||||||||||||||||||||||||||| ||||||:||:|||||| m913 DNKNTLGDTFASWGWKNSNYFVLPVLGPSTVRDALGTGITSVYSPKNIVFRTPVGRWGTT        130       140       150       160       170       180        190       200       210       220       230       240 g913.pep AAAAVSTREGLLDLTDSLDEAAIDKYSYTRDLYMKVRARQTGATPAEGTEDNIDIDIDEL |::||||||||||||||||||||||||||||||||||||||||||||||||||||  ||| m913 AVSAVSTREGLLDLTDSLDEAAIDKYSYTRDLYMKVRARQTGATPAEGTEDNIDI--DEL        190       200       210       220       230        250       260       270 g913.pep VESAETGAAEPAVHEDSVSETQAEAAGEAETQPGTQPX |||||||||| ||:|||||||||||||||||||||||| m913 VESAETGAAETAVQEDSVSETQAEAAGEAETQPGTQPX240       250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2769>:

a913.seq 1 ATGAAAAAAA CCGCCTATGC CTTCCTCCTG CTGATCGGGT TCGCTTCCGC 51CCCTGCATTT GCCGAAACCC GCCCCGCCGA CCCTTATGAA GGCTACAACC 101 GCGCCGTTTTCAAATTCAAC GACCAAGCCG ACCGCTACAT TTTCGCCCCT 151 GCCGCGCGCG GCTACCGCAAAGTTGCGCCG AAACCCGTCC GCGCCGGCGT 201 GTCCAATTTT TTTAACAACC TGTGCGACGTGGTCAGCTTC GGCAGCAATA 251 TCTTGCGCTT AGACATCAAA CGCGCAAGCG AAGACCTTGTCCGCGTCGGT 301 ATCAACACCA CTTTCGGTTT GGGCGGGCTT ATCGACATCG CCGGCGCGGG351 CGGCATTCCC GACAATAAAA ACACCTTGGG CGACACGTTT GCTTCGTGGG 401GATGGAAAAA CAGCAATTAT TTCGTGTTGC CCGTCTTAGG GCCGTCCACC 451 GTCCGCGACGCGCTCGGCAC GGGTATTACC TCCGTTTATT CGCCCAAGAA 501 TATCGTCTTC CGCACCCCTGTCGGACGCTG GGGCACGACT GCCGTATCCG 551 CCGTCAGTAC GCGCGAAGGC CTGCTCGATTTGACCGACAG TCTGGACGAA 601 GCCGCCATCG ACAAATACAG CTACACGCGC GACCTCTATATGAAAGTCCG 651 TGCGCGGCAG ACCGGTGCAA CACCTGCCGA AGGTACGGAA GATAACATCG701 ACATCGACGA ATTGGTCGAA AGTGCCGAAA CCGGCGCGGC GGAAACTGCC 751GTTCAAGAAG ATTCCGTATC CGAAACACAG GCAGAAGCAG CAGGGGAAGC 801 CGAAACGCAACCTGGAACAC AACCTGGAAC ACAACCTTAAThis corresponds to the amino acid sequence <SEQ ID 2770; ORF 913.a>:

a913.pep 1 MKKTAYAFLL LIGFASAPAF AETRPADPYE GYNRAVFKFN DQADRYIFAP 51AARGYRKVAP KPVRAGVSNF FNNLCDVVSF GSNILRLDIK RASEDLVRVG 101 INTTFGLGGLIDIAGAGGIP DNKNTLGDTF ASWGWKNSNY FVLPVLGPST 151 VRDALGTGIT SVYSPKNIVFRTPVGRWGTT AVSAVSTREG LLDLTDSLDE 201 AAIDKYSYTR DLYMKVRARQ TGATPAEGTEDNIDIDELVE SAETGAAETA 251 VQEDSVSETQ AEAAGEAETQ PGTQPGTQP* m913/a913100.0% identity in 275 aa overlap        10        20        30        40        50        60 m913.pepMKKTAYAFLLLIGFASAPAFAETRPADPYEGYNRAVFKFNDQADRYIFAPAARGYRKVAP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a913MKKTAYAFLLLIGFASAPAFAETRPADPYEGYNRAVFKFNDQADRYIFAPAARGYRKVAP        10        20        30        40        50        60        70        80        90       100       110       120 m913.pepKPVRAGVSNFFNNLCDVVSFGSNILRLDIKRASEDLVRVGINTTFGLGGLIDIAGAGGIP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a913KPVRAGVSNFFNNLCDVVSFGSNILRLDIKRASEDLVRVGINTTFGLGGLIDIAGAGGIP        70        80        90       100       110       120       130       140       150       160       170       180 m913.pepDNKNTLGDTFASWGWKNSNYFVLPVLGPSTVRDALGTGITSVYSPKNIVFRTPVGRWGTT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a913DNKNTLGDTFASWGWKNSNYFVLPVLGPSTVRDALGTGITSVYSPKNIVFRTPVGRWGTT       130       140       150       160       170       180       190       200       210       220       230       240 m913.pepAVSAVSTREGLLDLTDSLDEAAIDKYSYTRDLYMKVRARQTGATPAEGTEDNIDIDELVE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a913AVSAVSTREGLLDLTDSLDEAAIDKYSYTRDLYMKVRARQTGATPAEGTEDNIDIDELVE       190       200       210       220       230       240       250       260       270 m913.pepSAETGAAETAVQEDSVSETQAEAAGEAETQPGTQPX |||||||||||||||||||||||||||||||||||a913 SAETGAAETAVQEDSVSETQAEAAGEAETQPGTQPGTQPX       250       260       270       280The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2771>:

g914.seq 1 ATGAAAAAAT GTATTTTGGG CATTTTGACC GCGTGTGCCG CCATGCCTGC 51ATTTGCCGAC AGAATCAGCG ATTTGGAAGC ACGTCTGGCG CAGTTGGAAC 101 ACCGTGTCGCCGTATTGGAA AGCGGCGGCA ATACCGTCAA AATCGACCTT 151 TTCGGTTCAA ATTCCACCATGTATGTATGC AGCGTTACGC CTTTTCAGAA 201 GacgtttGag gCAAGCGATC GGAATGAAGGCGTGGCGCGG CAGAAAGTGC 251 GTCAGGCGTG CAACCGCGAA ACTTCGGCAA TGTTTTGCGGAGATGAGGCA 301 ATCCGATGCA GAAAATTCGA TTGATGTATC GGTTGGACGG ATAAAGAAAC351 GGATACGGAG CTTGGCTTCC GTCTCTGTTT TTCTCTGCCC GATTTTCCAT 401GCATCGGGTT TCAGACGGCA TTGGAGTGTC AGTCGTGTTC TGCCGATTCG 451 taggctTCGACGATTTTTTG CACCAGAGGA TGCCGGACAA CGTCTTCGCC 501 GGTGAAGGTA TGGAAATACAGTCCTGCCAC GCCGTGCAGT TTCTCACGTG 551 CGTCTTTCAA TCCCGATTTG ATGTTTTTGGGCAGGTcgaT TTGGCTGGTG 601 TCGCCGGTAA TGACGGCTTT CGCgccgaag ccGATGCGGGTCAGGAACAT 651 TTTCATTTGT TCGGGCGTGg tgTtttGcgC TTCGTCGAGG ATGATGTATG701 CGCCGTTGAg cgTCCTGCCG CGCATATAGThis corresponds to the amino acid sequence <SEQ ID 2772; ORF 914.ng>:

g914.pep 1 MKKCILGILT ACAAMPAFAD RISDLEARLA QLEHRVAVLE SGGNTVKIDL 51FGSNSTMYVC SVTPFQKTFE ASDRNEGVAR QKVRQACNRE TSAMFCGDEA 101 IRCRKFD*CIGWTDKETDTE LGFRLCFSLP DFPCIGFQTA LECQSCSADS 151 *ASTIFCTRG CRTTSSPVKVWKYSPATPCS FSRASFNPDL MFLGRSIWLV 201 SPVMTAFAPK PMRVRNIFIC SGVVFCASSRMMYAPLSVLP RI*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2773>:

m914.seq 1 ATGAAAAAAT GTATTTTGGG CATTTTGACC GCGTGTGCCG CCATGCCTGC 51ATTTGCCGAC AGAATCGGCG ATTTGGAAGC ACGTCTGGCG CAGTTGGAAC 101 ACCGTGTCGCCGTATTGGAA AGCGGCGGCA ATACCGTCAA AATCGACCTT 151 TTCGGTTCAA ATTCCACCATGTATGTATGC AGCGTTACGC CTTTTCAGAA 201 GACGTTTGAG GCAAGCGATC GGAATGAAGGCGTGGCGCGG CAGAAAGTGC 251 GTCAGGCGTG CAACCGCGAA ACTTCGGCAA TGTTTTGCGAAGATGAGGCA 301 ATCCGATGCA GAAAATTCGA TTGATGTATC GGTTGGACGG ATAAAGAAAC351 GGATACGGAT ACGGAGCTTG GCTTCCGTAT CTGTTTTTCT CTGCCTGATT 401TTCCATGCAT CGGGTTTCAG ACGGCATTGG AATGTCAGTC GTGTTCTGCC 451 GATTCGTAGGCTTCGACGAT TTTTTGCACC AAAGGATGCC GGACAACGTC 501 TTCGCCGGTA AAGGTGTGGAAATACAGCCC TTCCACGTTG TGCAGTTTCT 551 CACGCGCATC TTTTAATCCC GATTTGATGTTTTTGGGCAG GTCGATTTGG 601 CTGGTGTCGC CGGTAATGAC GGCTTTCGCG CCGAAGCCGATGCGGGTCAG 651 GAACATTTTC ATTTGTTCGG GCGTGGTGTT TTGCGCTTCG TCGAGGATGA701 TGTATGCGCC GTTGAGCGTC CTGCCGCGCA TATAGThis corresponds to the amino acid sequence <SEQ ID 2774; ORF 914>:

m914.pep 1 MKKCILGILT ACAAMPAFAD RIGDLEARLA QLEHRVAVLE SGGNTVKIDL 51FGSNSTMYVC SVTPFQKTFE ASDRNEGVAR QKVRQACNRE TSAMFCEDEA 101 IRCRKFDXCIGWTDKETDTD TELGFRICFS LPDFPCIGFQ TALECQSCSA 151 DSXASTIFCT KGCRTTSSPVKVWKYSPSTL CSFSRASFNP DLMFLGRSIW 201 LVSPVMTAFA PKPMRVRNIF ICSGVVFCASSRMMYAPLSV LPRI*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 914 shows 96.7% identity over a 244 aa overlap with a predicted ORF(ORF 914.ng) from N. gonorrhoeae:

g914/m914          10        20        30        40        50        60g914.pep  MKKCILGILTACAAMPAFADRISDLEARLAQLEHRVAVLESGGNTVKIDLFGSNSTMYVC ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||| m914 MKKCILGILTACAAMPAFADRIGDLEARLAQLEHRVAVLESGGNTVKIDLFGSNSTMYVC         10        20        30        40        50        60         70        80        90       100       110      119 g914.pep SVTPFQKTFEASDRNEGVARQKVRQACNRETSAMFCGDEAIRCRKFDXCIGWTDKETDT- |||||||||||||||||||||||||||||||||||| |||||||||||||||||||||| m914 SVTPFQKTFEASDRNEGVARQKVRQACNRETSAMFCEDEAIRCRKFDXCIGWTDKETDTD         70        80        90       100       110       120120       130       140       150       160       170 g914.pep -ELGFRLCFSLPDFPCIGFQTALECQSCSADSXASTIFCTRGCRTTSSPVKVWKYSPATP  |||||:|||||||||||||||||||||||||||||||||:||||||||||||||||:| m914 TELGFRICFSLPDFPCIGFQTALECQSCSADSXASTIFCTKGCRTTSSPVKVWKYSPSTL        130       140       150       160       170       180180       190       200       210       220       230 g914.pep CSFSRASFNPDLMFLGRSIWLVSPVMTAFAPKPMRVRNIFICSGVVFCASSRMMYAPLSV |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m914 CSFSRASFNPDLMFLGRSIWLVSPVMTAFAPKPMRVRNIFICSGVVFCASSRMMYAPLSV        190       200       210       220       230       240 240g914.pep  LPRIX  ||||| m914  LPRIXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2775>:

a914.seq 1 ATGAAAAAAT GTATTTTGGG CATTTTGACC GCGTGTGCCG CCATGCCTGC 51ATTTGCCGAC AGAATCGGCG ATTTGGAAGC ACGTCTGGCG CAGTTGGAAC 101 ACCGTGTCGCCGTATTGGAA AGCGGCAGCA ATACCGTCAA AATCGACCTT 151 TTCGGTTCAA ATTCCACCATGTATGTATGC AGCGTTACGC CTTTTCAGAA 201 GACGTTTGAG GCAAGCGATC GGAATGAAGGCGTGGCGCGG CAGAAAGTGC 251 GTCAGGCGTG CAACCGCGAA ACTTCGGCAA TGTTTTGCGAAGATGAGGCA 301 ATCCGATGCA GAAAATTCGA TTGATGTATC GGTTGGACGG ATAAAGAAAC351 GGATACGGAG CTTGGCTTCC GTATCTGTTT TTCTCTGCCC GATTTTCCAT 401GCATCGGGTT TCAGACGGCA TTGGAATGTC AGTCGTGTTC TGCCGATTCG 451 TAGGCTTCGACGATTTTTTG CACCAAAGGA TGCCGGACAA CGTCTTCGCC 501 GGTAAAGGTG TGGAAATACAGCCCTTCCAC GCCGTGCAGT TTCTCACGCG 551 CATCTTTTAA TCCCGATTTG ATGTTTTTGGGCAGGTCGAT TTGGCTGGTG 601 TCGCCGGTAA TGACGGCTTT CGCGCCGAAG CCGATGCGGGTCAGGAACAT 651 TTTCATTTGT TCGGGCGTGG TGTTTTGCGC TTCGTCGAGG ATGATGTATG701 CGCCGTTGAG CGTCCTGCCG CGCATATAGThis corresponds to the amino acid sequence <SEQ ID 2776; ORF 914.a>:

a914.pep 1 MKKCILGILT ACAAMPAFAD RIGDLEARLA QLEHRVAVLE SGSNTVKIDL 51FGSNSTMYVC SVTPFQKTFE ASDRNEGVAR QKVRQACNRE TSAMFCEDEA 101 IRCRKFD*CIGWTDKETDTE LGFRICFSLP DFPCIGFQTA LECQSCSADS 151 *ASTIFCTKG CRTTSSPVKVWKYSPSTPCS FSRASFNPDL MFLGRSIWLV 201 SPVMTAFAPK PMRVRNIFIC SGVVFCASSRMMYAPLSVLP RI* m914/a914 98.4% identity in 244 aa overlap         10        20        30        40        50        60 m914.pep MKKCILGILTACAAMPAFADRIGDLEARLAQLEHRVAVLESGGNTVKIDLFGSNSTMYVC ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||| a914 MKKCILGILTACAAMPAFADRIGDLEARLAQLEHRVAVLESGSNTVKIDLFGSNSTMYVC         10        20        30        40        50        60         70        80        90       100       110       120 m914.pep SVTPFQKTFEASDRNEGVARQKVRQACNRETSAMFCEDEAIRCRKFDXCIGWTDKETDTD |||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a914 SVTPFQKTFEASDRNEGVARQKVRQACNRETSAMFCEDEAIRCRKFDXCIGWTDKETD--         70        80        90       100       110        130       140       150       160       170       180 m914.pep TELGFRICFSLPDFPCIGFQTALECQSCSADSXASTIFCTKGCRTTSSPVKVWKYSPSTL ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a914 TELGFRICFSLPDFPCIGFQTALECQSCSADSXASTIFCTKGCRTTSSPVKVWKYSPSTP120       130       140       150       160       170        190       200       210       220       230       240 m914.pep CSFSRASFNPDLMFLGRSIWLVSPVMTAFAPKPMRVRNIFICSGVVFCASSRMMYAPLSV |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a914 CSFSRASFNPDLMFLGRSIWLVSPVMTAFAPKPMRVRNIFICSGVVFCASSRMMYAPLSV180       190       200       210       220       230 m914.pep  LPRIX ||||| a914  LPRIX 240The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2777>:

g915.seq 1 ATGAAGAAAA CCCTGTTGGc AATTGTTGCC gtTTTCGCCT TAAGTGCCTG 51CCGGCaggcg gaAGaggcac cgccgCCTTT ACCCCGGCAG AtTAGCGacc 101 gttcggtcggaCACTAttgC Agtatgaacc tgaccgaaca caacggcccc 151 aaagcccaga tttttttgaacGGCAAACCC GATCAGCCCG TTTGGTTCTC 201 CACCGTcaag cagatgttcg GCTATACCAAGCTGCCCGAA GAGCCCAAAG 251 GCATCCGCGT GATTTACGTT ACCGATATGG GCAATGTTACCGATTGGACG 301 AATCCTAATG CCGACACGGA GTGGATAGAT GCGAAAAAAG CCTTTTACGT351 CATCGACAGC GGCTTTATCG GCGGTATGGG CGCGGAAGAC GCGCTGCCGT 401TCGGCAACAA GGAGCAGGCT GAAAAATTTG CAAAGGATAA AGGCGGCAAG 451 GTCGTCGGTTTTGACGATAT GCCCGATGCT TACATTTTCA AGTAAThis corresponds to the amino acid sequence <SEQ ID 2778; ORF 915.ng>:

g915.pep 1 MKKTLLAIVA VFALSACRQA EEAPPPLPRQ ISDRSVGHYC SMNLTEHNGP 51KAQIFLNGKP DQPVWFSTVK QMFGYTKLPE EPKGIRVIYV TDMGNVTDWT 101 NPNADTEWIDAKKAFYVIDS GFIGGMGAED ALPFGNKEQA EKFAKDKGGK 151 VVGFDDMPDA YIFK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2779>:

m915.seq 1 ATGAAAAAAA CCCTGTTGGC AATTGTTGCC GTTTCCGCCT TAAGTGC.tG 51CCGGCAGGCG GAAGAGGGAC CGCCGCCTTT ACCcCGGCAG ATTAGCGACC 101 GTTCGGTCGGACACTATTGC AGTATGAACC TGACCGAACA CAACGGCCCC 151 AAAGCCCAGA TTTTCTTGAACGGCAAACCC GATCAGCCCG TtTGGTTCTC 201 CACCATCAAG CAGATGTTCG GCTATACCAAGCTGCCCGAA GAGCCTAAAG 251 GCATCCGCGT GATTTACGTT ACCGATATGG GCAATGTTACCGATTGGACG 301 AATCCCAATG CCGACACGGA GTGGATGGAT GCGAAAAAAG CCTTTTACGT351 CATCGACAGC GGCTTTATCG GCGGTATGGG TGCGGAAGAC GCGCTGCCGT 401TCGGCAACAA AGAGCAGGCT GAGAAATTTG CAAAGGATAA AGGCGGTAAG 451 GTTGTCGGTTTCGACGATAT GCCTGATACC TATATTTTCA AATAAThis corresponds to the amino acid sequence <SEQ ID 2780; ORF 915>:

m915.pep 1 MKKTLLAIVA VSALSXCRQA EEGPPPLPRQ ISDRSVGHYC SMNLTEHNGP 51KAQIFLNGKP DQPVWFSTIK QMFGYTKLPE EPKGIRVIYV TDMGNVTDWT 101 NPNADTEWMDAKKAFYVIDS GFIGGMGAED ALPFGNKEQA EKFAKDKGGK 151 VVGFDDMPDT YIFK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 915 shows 97.0% identity over a 164 aa overlap with a predicted ORF(ORF 915.ng) from N. gonorrhoeae:

m915/g915         10        20        30        40        50        60m915.pep MKKTLLAIVAVSALSACRQAEEGPPPLPRQISDRSVGHYCSMNLTEHNGPKAQIFLNGKP||||||||||| ||||||||||:||||||||||||||||||||||||||||||||||||| g915MKKTLLAIVAVFALSACRQAEEAPPPLPRQISDRSVGHYCSMNLTEHNGPKAQIFLNGKP        10        20        30        40        50        60        70        80        90       100       110       120 m915.pepDQPVWFSTIKQMFGYTKLPEEPKGIRVIYVTDMGNVTDWTNPNADTEWMDAKKAFYVIDS||||||||:|||||||||||||||||||||||||||||||||||||||:||||||||||| g915DQPVWFSTVKQMFGYTKLPEEPKGIRVIYVTDMGNVTDWTNPNADTEWIDAKKAFYVIDS        70        80        90       100       110       120       130       140       150       160 m915.pepGFIGGMGAEDALPFGNKEQAEKFAKDKGGKVVGFDDMPDTYIFKX|||||||||||||||||||||||||||||||||||||||:||||| g915GFIGGMGAEDALPFGNKEQAEKFAKDKGGKVVGFDDMPDAYIFKX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2781>:

a915.seq 1 ATGAAAAAAA CCCTGTTGGC AATTGTTGCC GTTTCCGCCT TAAGTGCCTG 51CCGGCAGGCG GAAGAGGGAC CGCCGCCTTT ACCCCGGCAG ATTAGCGACC 101 GTTCGGTCGGACACTATTGC AGTATGAACC TGACCGAACA CAACGGCCCC 151 AAAGCCCAGA TTTTCTTGAACGGCAAACCC GATCAGCCCG TTTGGTTCTC 201 CACCATCAAG CAGATGTTCG GCTATACCAAGCTGCCCGAA GAGCCTAAAG 251 GCATCCGCGT GATTTACGTT ACCGATATGG GCAATGTTACCGATTGGACG 301 AATCCCAATG CCGACACGGA GTGGATGGAT GCGAAAAAAG CCTTTTACGT351 CATCGACAGC GGCTTTATCG GCGGTATGGG TGCGGAAGAC GCGCTGCCGT 401TCGGCAACAA AGAGCAGGCT GAGAAATTTG CAAAGGATAA AGGCGGTAAG 451 GTTGTCGGTTTCGACGATAT GCCTGATACC TATATTTTCA AATAAThis corresponds to the amino acid sequence <SEQ ID 2782; ORF 915.a>:

a915.pep 1 MKKTLLAIVA VSALSACRQA EEGPPPLPRQ ISDRSVGHYC SMNLTEHNGP 51KAQIFLNGKP DQPVWFSTIK QMFGYTKLPE EPKGIRVIYV TDMGNVTDWT 101 NPNADTEWMDAKKAFYVIDS GFIGGMGAED ALPFGNKEQA EKFAKDKGGK 151 VVGFDDMPDT YIFK*m915/a915 99.4% identity in 164 aa overlap        10        20        30        40        50        60 m915.pepMKKTLLAIVAVSALSXCRQAEEGPPPLPRQISDRSVGHYCSMNLTEHNGPKAQIFLNGKP||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| a915MKKTLLAIVAVSALSACRQAEEGPPPLPRQISDRSVGHYCSMNLTEHNGPKAQIFLNGKP        10        20        30        40        50        60        70        80        90       100       110       120 m915.pepDQPVWFSTIKQMFGYTKLPEEPKGIRVIYVTDMGNVTDWTNPNADTEWMDAKKAFYVIDS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a915DQPVWFSTIKQMFGYTKLPEEPKGIRVIYVTDMGNVTDWTNPNADTEWMDAKKAFYVIDS        70        80        90       100       110       120       130       140       150       160 m915.pepGFIGGMGAEDALPFGNKEQAEKFAKDKGGKVVGFDDMPDTYIFKX||||||||||||||||||||||||||||||||||||||||||||| a915GFIGGMGAEDALPFGNKEQAEKFAKDKGGKVVGFDDMPDTYIFKX       130       140       150       160The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2783>:

g917.seq 1 ATGGTCAAac atctgccacT cgcCGTCctg actgctTtgc tgcttgcagc 51gtgcGGCGGT Tcggacaaac cgcctgccga Aaaaccggca ccggcgGaAA 101 accaaAacgtatTgaAAATT TataACTGGT CGGAATACGT CGATCCGGAA 151 ACCGTTGCCG ATTTTGAAAAGAAAAACGGC ATCAAGGTTA CTTATGATGT 201 GTACGACAGT GATGAAACGC TGGAAAGCAAGGTGCTGACC GGAAAATCCG 251 GTTACGACAT TGTCGCGCCG TCCAATGCGT TTGTGGGCAGGCAGATTAAG 301 GCAGGTGCGT ATCAGAAAAT CGATAAGTCG ATGATTCCCA ATTATAAACA351 TCTCAACCCT GAAATGATGA GGCTGATGGA CGGGGTCGAT CCCGACCACG 401AATACGCCGT GCCGTTTTAT TGGGGGACAA ATACCTTCGC CATCAATACC 451 GAACGCGTGAAAAAGGCTTT GGGTACGGAC AAGCTGCCGG ACAACCAGTG 501 GGATTTGGTG TTCAACCCCGAATACACGTT CAAACTCAAA CAATGCGGCA 551 TCAGCTATTT GGACAGCGCG GCGGAAATTTATCCCATGGT GTTGAACTAT 601 TTGGGCAAAA ACCCGAACAG CAGCAATACG GAAGACATCAGGGAGGCAAC 651 CGCCCTGCTC AAGAAAAACC GCCCCAATAT CAAACGCTTT ACTTCGTCCG701 GCTTTATCGA TGATTTGGCG CGCGGCGATA CCTGCGTAAC AATCGGTTTC 751GGCGGAGATT TGAACATCGC CAAACGCCGT GCCGAAGAAG CGGGCGGCAA 801 GGAAAAAATCCGCGTGATGA TGCCGAAAGA GGGCGTGGGG ATTTGGGTGG 851 ATTCTTTCGT GATTCCGAAAGATGCGAAAA ACGTCGCCAA CGCGCACAAA 901 TACATCAACG ACTTCCTCGA TCCGGAAGTGTCGGCGAAAA ACGGCAATTT 951 cgttacCTAC GCGCCTTCGA GCAAGCCGGC GCGCGATTTGATGGAGGACG 1001 AATTTAAAAA CGACAATACG ATTTTCCCGA GCGGGGAAGA TTTGAAAAAC1051 AGCTTTATCA TGGTGCCTAT CCGGCCGGCG GCATTGAAGT TTATGGTGCG 1101CCAGTGGCAG GATGTGAAGG CGGGGAAATA AThis corresponds to the amino acid sequence <SEQ ID 2784; ORF 917.ng>:

g917.pep 1 MVKHLPLAVL TALLLAACGG SDKPPAEKPA PAENQNVLKI YNWSEYVDPE 51TVADFEKKNG IKVTYDVYDS DETLESKVLT GKSGYDIVAP SNAFVGRQIK 101 AGAYQKIDKSMIPNYKHLNP EMMRLMDGVD PDHEYAVPFY WGTNTFAINT 151 ERVKKALGTD KLPDNQWDLVFNPEYTFKLK QCGISYLDSA AEIYPMVLNY 201 LGKNPNSSNT EDIREATALL KKNRPNIKRFTSSGFIDDLA RGDTCVTIGF 251 GGDLNIAKRR AEEAGGKEKI RVMMPKEGVG IWVDSFVIPKDAKNVANAHK 301 YINDFLDPEV SAKNGNFVTY APSSKPARDL MEDEFKNDNT IFPSGEDLKN351 SFIMVPIRPA ALKFMVRQWQ DVKAGK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2785>:

m917.seq 1 ATGACCAAAC ATCTGCCCCT GGCCGTCCTG ACTGCTTTGC TGCTTGCAGC 51GTGCGGCGGT TCGGACAAAC CGCCTGCCGA AAAACCGGCA CCGGCGGAAA 101 ACCAAAACGTATTGAAAATT TACAACTGGT CGGAATATGT CGATCCGGAA 151 ACCGTTGCCG ATTTTGAAAAGAAAAACGGC ATCAAGGTTA CTTATGATGT 201 GTACGACAGC GATGAAACGC TGGAAAGCAAGGTGCTGACA GGCAAGTCCG 251 GTTACGACAT TGTCGCGCCG TCCAATGCGT TTGTGGGCAGGCAGATTAAG 301 GCAGGTGCGT ATCAGAAAAT CGATAAGTCG CTGATTCCCA ATTATAAACA351 CCTCAACCCC GAAATGATGA GGCTGATGGA CGGGGTCGAT CCCGGCCACG 401AATACGCCGT GCCGTTTTAT TGGGGGACAA ATACCTTCGC CATCAATACC 451 GAACGCGTGAAAAAGGCTTT GGGTACGGAC AAGCTGCCGG ACAACCAGTG 501 GGATTTGGTG TTCGACCCCGAATACACGTC CAAACTCAAG CAATGCGGCA 551 TCAGCTATTT GGACAGCGCG GCGGAAATCTATCCTATGGT GTTGAACTAT 601 TTGGGTAAAA ACCCGAACAG CAGCAATACG GAAGACATCAGGGAGGCAAC 651 CGCCCTACTC AAGAAAAACC GCCCCAATAT CAAACGCTTT ACTTCGTCCG701 GCTTTATCGA TGATTTGGCG CGCGGCGATA CCTGCGTAAC AATCGGTTTC 751GGCGGCGATT TGAACATCGC CAAACGCCGT GCCGAAGAAG CGGGCGGCAA 801 GGAAAAAATCCGCGTGATGA TGCCCAAAGA GGGCGTGGGG ATTTGGGTGG 851 ATTCTTTCGT GATTCCGAAAGATGCGAAAA ACGTCGCCAA CGCGCACAAA 901 TACATCAACG ACTTCCTCGA CCCGGAAGTGTCGGCGAAAA ACGGCAATTT 951 CGTTACTTAC GCGCCTTCGA GCAAGCCTGC GCGTGAGCTGATGGAAGACG 1001 AATTTAAAAA CGACAATACG ATTTTCCCAA CCGAGGAGGA TTTGAAAAAC1051 AGCTTTATCA TGGTGCCTAT CCAGCCGGCG GCATTGAAGT TTATGGTGCG 1101CCAGTGGCAG GATGTGAAGG CGGGGAAATA AThis corresponds to the amino acid sequence <SEQ ID 2786; ORF 917>:

m917.pep 1 MTKHLPLAVL TALLLAACGG SDKPPAEKPA PAENQNVLKI YNWSEYVDPE 51TVADFEKKNG IKVTYDVYDS DETLESKVLT GKSGYDIVAP SNAFVGRQIK 101 AGAYQKIDKSLIPNYKHLNP EMMRLMDGVD PGHEYAVPFY WGTNTFAINT 151 ERVKKALGTD KLPDNQWDLVFDPEYTSKLK QCGISYLDSA AEIYPMVLNY 201 LGKNPNSSNT EDIREATALL KKNRPNIKRFTSSGFIDDLA RGDTCVTIGF 251 GGDLNIAKRR AEEAGGKEKI RVMMPKEGVG IWVDSFVIPKDAKNVANAHK 301 YINDFLDPEV SAKNGNFVTY APSSKPAREL MEDEFKNDNT IFPTEEDLKN351 SFIMVPIQPA ALKFMVRQWQ DVKAGK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 917 shows 97.6% identity over a 376 aa overlap with a predicted ORF(ORF 917.ng) from N. gonorrhoeae:

m917/g917         10        20        30        40        50        60m917.pep MTKHLPLAVLTALLLAACGGSDKPPAEKPAPAENQNVLKIYNWSEYVDPETVADFEKKNG|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g917MVKHLPLAVLTALLLAACGGSDKPPAEKPAPAENQNVLKIYNWSEYVDPETVADFEKKNG        10        20        30        40        50        60        70        80        90       100       110       120 m917.pepIKVTYDVYDSDETLESKVLTGKSGYDIVAPSNAFVGRQIKAGAYQKIDKSLIPNYKHLNP||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| g917IKVTYDVYDSDETLESKVLTGKSGYDIVAPSNAFVGRQIKAGAYQKIDKSMIPNYKHLNP        70        80        90       100       110       120       130       140       150       160       170       180 m917.pepEMMRLMDGVDPGHEYAVPFYWGTNTFAINTERVKKALGTDKLPDNQWDLVFDPEYTSKLK||||||||||| |||||||||||||||||||||||||||||||||||||||:|||| ||| g917EMMRLMDGVDPDHEYAVPFYWGTNTFAINTERVKKALGTDKLPDNQWDLVFNPEYTFKLK       130       140       150       160       170       180       190       200       210       220       230       240 m917.pepQCGISYLDSAAEIYPMVLNYLGKNPNSSNTEDIREATALLKKNRPNIKRFTSSGFIDDLA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g917QCGISYLDSAAEIYPMVLNYLGKNPNSSNTEDIREATALLKKNRPNIKRFTSSGFIDDLA       190       200       210       220       230       240       250       260       270       280       290       300 m917.pepRGDICVTIGFGGDLNIAKRRAEEAGGKEKIRVMMPKEGVGIWVDSFVIPKDAKNVANAHK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g917RGDTCVTIGFGGDLNIAKRRAEEAGGKEKIRVMMPKEGVGIWVDSFVIPKDAKNVANAHK       250       260       270       280       290       300       310       320       330       340       350       360 m917.pepYINDFLDPEVSAKNGNFVTYAPSSKPARELMEDEFKNDNTIFPTEEDLKNSFIMVPIQPA||||||||||||||||||||||||||||:||||||||||||||: ||||||||||||:|| g917YINDFLDPEVSAKNGNFVTYAPSSKPARDLMEDEFKNDNTIFPSGEDLKNSFIMVPIRPA       310       320       330       340       350       360        370m917.pep ALKFMVRQWQDVKAGKX ||||||||||||||||| g917 ALKFMVRQWQDVKAGKX       370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2787>:

a917.seq 1 ATGACCAAAC ATCTGCCCCT GGCCGTCCTG ACTGCTTTGC TGCTTGCAGC 51GTGCGGCGGT TCGGACAAAC CGCCTGCCGA AAAACCGGCG CCGGCGGAAA 101 ACCGAAACGTATTGAAAATT TACAACTGGT CGGAATACGT CGATCCGGAA 151 ACCGTTGCCG ATTTTGAAAAGAAAAACGGC ATCAAGGTTA CTTATGATGT 201 GTACGACAGC GATGAAACGC TGGAAAGCAAGGTGCTGACC GGAAAATCTG 251 GTTACGACAT TGTCGCGCCG TCCAATGCGT TTGTGGGCAGGCAGATTAAG 301 GCAGGTGCGT ATCAGAAAAT CGATAAGTCG CTGATTCCCA ATTATAAACA351 CCTCAACCCC GAAATGATGA GGCTGATGGA CGGGGTCGAT CCCGGCCACG 401AATACGCCGT GCCGTTTTAT TGGGGGACAA ATACCTTCGC CATCAATACC 451 GAACGCGTGAAAAAGGCTTT GGGTACGGAC AAGCTGCCGG ACAACCAGTG 501 GGATTTGGTG TTCGACCCCGAATACACGTC CAAACTCAAG CAATGCGGCA 551 TCAGCTATTT GGACAGCGCG GCGGAAATCTATCCTATGGT GTTGAACTAT 601 TTGGGTAAAA ACCCGAACAG CAGCAATACG GAAGACATCAGGGAGGCAAC 651 CGCCCTACTC AAGAAAAACC GCCCCAATAT CAAACGCTTT ACTTCGTCCG701 GCTTTATCGA TGATTTGGCG CGCGGCGATA CCTGCGTAAC AATCGGTTTC 751GGCGGCGATT TGAACATCGC CAAACGCCGT GCCGAAGAAG CGGGCGGCAA 801 GGAAAAAATCCGCGTGATGA TGCCCAAAGA GGGCGTGGGG ATTTGGGTGG 851 ATTCTTTCGT GATTCCGAAAGATGCGAAAA ACGTCGCCAA CGCGCACAAA 901 TACATCAACG ACTTCCTCGA CCCGGAAGTGTCGGCGAAAA ACGGCAATTT 951 CGTTACTTAC GCGCCTTCGA GCAAGCCTGC GCGTGAGCTGATGGAAGACG 1001 AATTTAAAAA CGACAATACG ATTTTCCCAA CCGAGGAGGA TTTGAAAAAC1051 AGCTTTATCA TGGTGCCTAT CCAGCCGGCG GCATTGAAGT TTATGGTGCG 1101CCAGTGGCAG GATGTGAAGG CGGGGAAATA AThis corresponds to the amino acid sequence <SEQ ID 2788; ORF 917.a>:

a917.pep 1 MTKHLPLAVL TALLLAACGG SDKPPAEKPA PAENRNVLKI YNWSEYVDPE 51TVADFEKKNG IKVTYDVYDS DETLESKVLT GKSGYDIVAP SNAFVGRQIK 101 AGAYQKIDKSLIPNYKHLNP EMMRLMDGVD PGHEYAVPFY WGTNTFAINT 151 ERVKKALGTD KLPDNQWDLVFDPEYTSKLK QCGISYLDSA AEIYPMVLNY 201 LGKNPNSSNT EDIREATALL KKNRPNIKRFTSSGFIDDLA RGDTCVTIGF 251 GGDLNIAKRR AEEAGGKEKI RVMMPKEGVG IWVDSFVIPKDAKNVANAHK 301 YINDFLDPEV SAKNGNFVTY APSSKPAREL MEDEFKNDNT IFPTEEDLKN351 SFIMVPIQPA ALKFMVRQWQ DVKAGK* m917/a917 99.7% identity in 376 aaoverlap         10        20        30        40        50        60m917.pep MTKHLPLAVLTALLLAACGGSDKPPAEKPAPAENQNVLKIYNWSEYVDPETVADFEKKNG||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||| a917MTKHLPLAVLTALLLAACGGSDKPPAEKPAPAENRNVLKIYNWSEYVDPETVADFEKKNG        10        20        30        40        50        60        70        80        90       100       110       120 m917.pepIKVTYDVYDSDETLESKVLTGKSGYDIVAPSNAFVGRQIKAGAYQKIDKSLIPNYKHLNP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a917IKVTYDVYDSDETLESKVLTGKSGYDIVAPSNAFVGRQIKAGAYQKIDKSLIPNYKHLNP        70        80        90       100       110       120       130       140       150       160       170       180 m917.pepEMMRLMDGVDPGHEYAVPFYWGTNTFAINTERVKKALGTDKLPDNQWDLVFDPEYTSKLK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a917EMMRLMDGVDPGHEYAVPFYWGTNTFAINTERVKKALGTDKLPDNQWDLVFDPEYTSKLK       130       140       150       160       170       180       190       200       210       220       230       240 m917.pepQCGISYLDSAAEIYPMVLNYLGKNPNSSNTEDIREATALLKKNRPNIKRFTSSGFIDDLA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a917QCGISYLDSAAEIYPMVLNYLGKNPNSSNTEDIREATALLKKNRPNIKRFTSSGFIDDLA       190       200       210       220       230       240       250       260       270       280       290       300 m917.pepRGDICVTIGFGGDLNIAKRRAEEAGGKEKIRVMMPKEGVGIWVDSFVIPKDAKNVANAHK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a917RGDICVTIGFGGDLNIAKRRAEEAGGKEKIRVMMPKEGVGIWVDSFVIPKDAKNVANAHK       250       260       270       280       290       300       310       320       330       340       350       360 m917.pepYINDFLDPEVSAKNGNFVTYAPSSKPARELMEDEFKNDNTIFPTEEDLKNSFIMVPIQPA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a917YINDFLDPEVSAKNGNFVTYAPSSKPARELMEDEFKNDNTIFPTEEDLKNSFIMVPIQPA       310       320       330       340       350       360        370m917.pep ALKFMVRQWQDVKAGKX ||||||||||||||||| a917 ALKFMVRQWQDVKAGKX       370The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 2789>:

g919.seq 1 ATGAAAAAAC ACCTGCTCCG CTCCGCCCTG TACGGcatCG CCGCCgccAT 51CctcgCCGCC TGCCAAAgca gGAGCATCCA AACCTTTCCG CAACCCGACA 101 CATCCGTCATCAACGGCCCG GACCGGCCGG CCGGCATCCC CGACCCCGCC 151 GGAACGACGG TTGCCGGCGGCGGGGCCGTC TATACCGTTG TGCCGCACCT 201 GTCCATGCCC CACTGGGCGG CGCaggATTTTGCCAAAAGC CTGCAATCCT 251 TCCGCCTCGG CTGCGCCAAT TTGAAAAACC GCCAAGGCTGGCAGGATGTG 301 TGCGCCCAAG CCTTTCAAAC CCCCGTGCAT TCCTTTCAGG CAAAGcGgTT351 TTTTGAACGC TATTTCACGC cgtGGCaggt tgcaggcaAC GGAAGcCTTG 401Caggtacggt TACCGGCTAT TACGAACCGG TGCTGAAGGG CGACGGCAGG 451 CGGACGGAACGGGCCCGCTT CCCGATTTAC GGTATTCCCG ACGATTTTAT 501 CTCCGTCCCG CTGCCTGCCGGTTTGCGGGG CGGAAAAAAC CTTGTCCGCA 551 TCAGGCAGac ggGGAAAAAC AGCGGCACGATCGACAATGC CGGCGGCACG 601 CATACCGCCG ACCTCTCCCG ATTCCCCATC ACCGCGCGCACAACGGcaat 651 caaaGGCAGG TTTGAaggAA GCCGCTTCCT CCCTTACCAC ACGCGCAACC701 AAAtcaacGG CGGCgcgcTT GACGGCAAag cccCCATCCT CggttacgcC 751GAagaccCcG tcgaacttTT TTTCATGCAC AtccaaggCT CGGGCCGCCT 801 GAAAACCCcgtccggcaaat acatCCGCAt cggaTacgcc gacAAAAACG 851 AACAtccgTa tgtttccatcggACGctaTA TGGCGGACAA AGGCTACCTC 901 AAGctcgggc agACCTCGAT GCAGGgcatcaaagcCTATA TGCGGCAAAA 951 TCCGCAACGC CTCGCCGAAG TTTTGGGTCA AAACCCCAGCTATATCTTTT 1001 TCCGCGAGCT TGCCGGAAGC GGCAATGAGG GCCCCGTCGG CGCACTGGGC1051 ACGCCACTGA TGGGGGAATA CGCCGGCGCA ATCGACCGGC ACTACATTAC 1101CTTGGGCGCG CCCTTATTTG TCGCCACCGC CCATCCGGTT ACCCGCAAAG 1151 CCCTCAACCGCCTGATTATG GCGCAGGATA CAGGCAGCGC GATCAAAGGC 1201 GCGGTGCGCG TGGATTATTTTTGGGGTTAC GGCGACGAAG CCGGCGAACT 1251 TGCCGGCAAA CAGAAAACCA CGGGATACGTCTGGCAGCTC CTGCCCAACG 1301 GCATGAAGCC CGAATACCGC CCGTGAThis corresponds to the amino acid sequence <SEQ ID 2790; ORF 919.ng>:

g919.pep 1 MKKHLLRSAL YGIAAAILAA CQSRSIQTFP QPDTSVINGP DRPAGIPDPA 51GTTVAGGGAV YTVVPHLSMP HWAAQDFAKS LQSFRLGCAN LKNRQGWQDV 101 CAQAFQTPVHSFQAKRFFER YFTPWQVAGN GSLAGTVTGY YEPVLKGDGR 151 RTERARFPIY GIPDDFISVPLPAGLRGGKN LVRIRQTGKN SGTIDNAGGT 201 HTADLSRFPI TARTTAIKGR FEGSRFLPYHTRNQINGGAL DGKAPILGYA 251 EDPVELFFMH IQGSGRLKTP SGKYIRIGYA DKNEHPYVSIGRYMADKGYL 301 KLGQTSMQGI KAYMRQNPQR LAEVLGQNPS YIFFRELAGS GNEGPVGALG351 TPLMGEYAGA IDRHYITLGA PLFVATAHPV TRKALNRLIM AQDTGSAIKG AVRVDYFWGYGDEAGELAGK QKTTGYVWQL LPNGMKPEYR P*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2791>:

m919.seq 1 ATGAAAAAAT ACCTATTCCG CGCCGCCCTG TACGGCATCG CCGCCGCCAT 51CCTCGCCGCC TGCCAAAGCA AGAGCATCCA AACCTTTCCG CAACCCGACA 101 CATCCGTCATCAACGGCCCG GACCGGCCGG TCGGCATCCC CGACCCCGCC 151 GGAACGACGG TCGGCGGCGGCGGGGCCGTC TATACCGTTG TACCGCACCT 201 GTCCCTGCCC CACTGGGCGG CGCAGGATTTCGCCAAAAGC CTGCAATCCT 251 TCCGCCTCGG CTGCGCCAAT TTGAAAAACC GCCAAGGCTGGCAGGATGTG 301 TGCGCCCAAG CCTTTCAAAC CCCCGTCCAT TCCTTTCAGG CAAAACAGTT351 TTTTGAACGC TATTTCACGC CGTGGCAGGT TGCAGGCAAC GGAAGCCTTG 401CCGGTACGGT TACCGGCTAT TACGAACCGG TGCTGAAGGG CGACGACAGG 451 CGGACGGCACAAGCCCGCTT CCCGATTTAC GGTATTCCCG ACGATTTTAT 501 CTCCGTCCCC CTGCCTGCCGGTTTGCGGAG CGGAAAAGCC CTTGTCCGCA 551 TCAGGCAGAC GGGAAAAAAC AGCGGCACAATCGACAATAC CGGCGGCACA 601 CATACCGCCG ACCTCTCCcG ATTCCCCATC ACCGCGCGCACAACAGCAAT 651 CAAAGGCAGG TTTGAAGGAA GCCGCTTCCT CCCCTACCAC ACGCGCAACC701 AAATCAACGG CGGCGCGCTT GACGGCAAAG CCCCGATACT CGGTTACGCC 751GAAGACCCTG TCGAACTTTT TTTTATGCAC ATCCAAGGCT CGGGCCGTCT 801 GAAAACCCCGTCCGGCAAAT ACATCCGCAT CGGCTATGCC GACAAAAACG 851 AACATCCyTA CGTTTCCATCGGACGCTATA TGGCGGATAA GGGCTACCTC 901 AAACTCGGAC AAACCTCCAT GCAGGGCATTAAGTCTTATA TGCGGCAAAA 951 TCCGCAACGC CTCGCCGAAG TTTTGGGTCA AAACCCCAGCTATATCTTTT 1001 TCCGCGAGCT TGCCGGAAGC AGCAATGACG GCCCTGTCGG CGCACTGGGC1051 ACGCCGCTGA TGGGGGAATA TGCCGGCGCA GTCGACCGGC ACTACATTAC 1101CTTGGGTGCG CCCTTATTTG TCGCCACCGC CCATCCGGTT ACCCGCAAAG 1151 CCCTCAACCGCCTGATTATG GCGCAGGATA CCGGCAGCGC GATTAAAGGC 1201 GCGGTGCGCG TGGATTATTTTTGGGGATAC GGCGACGAAG CCGGCGAACT 1251 TGCCGGCAAA CAGAAAACCA CGGGATATGTCTGGCAGCTC CTACCCAACG GTATGAAGCC CGAATACCGc CCGTAAThis corresponds to the amino acid sequence <SEQ ID 2792; ORF 919>:

m919.pep 1 MKKYLFRAAL YGIAAAILAA CQSKSIQTFP QPDTSVINGP DRPVGIPDPA 51GTTVGGGGAV YTVVPHLSLP HWAAQDFAKS LQSFRLGCAN LKNRQGWQDV 101 CAQAFQTPVHSFQAKQFFER YFTPWQVAGN GSLAGTVTGY YEPVLKGDDR 151 RTAQARFPIY GIPDDFISVPLPAGLRSGKA LVRIRQTGKN SGTIDNTGGT 201 HTADLSRFPI TARTTAIKGR FEGSRFLPYHTRNQINGGAL DGKAPILGYA 251 EDPVELFFMH IQGSGRLKTP SGKYIRIGYA DKNEHPYVSIGRYMADKGYL 301 KLGQTSMQGI KSYMRQNPQR LAEVLGQNPS YIFFRELAGS SNDGPVGALG351 TPLMGEYAGA VDRHYITLGA PLFVATAHPV TRKALNRLIM AQDTGSAIKG 401AVRVDYFWGY GDEAGELAGK QKTTGYVWQL LPNGMKPEYR P*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2793>:

a919.seq 1 ATGAAAAAAT ACCTATTCCG CGCCGCCCTG TGCGGCATCG CCGCCGCCAT 51CCTCGCCGCC TGCCAAAGCA AGAGCATCCA AACCTTTCCG CAACCCGACA 101 CATCCGTCATCAACGGCCCG GACCGGCCGG TCGGCATCCC CGACCCCGCC 151 GGAACGACGG TCGGCGGCGGCGGGGCCGTT TATACCGTTG TGCCGCACCT 201 GTCCCTGCCC CACTGGGCGG CGCAGGATTTCGCCAAAAGC CTGCAATCCT 251 TCCGCCTCGG CTGCGCCAAT TTGAAAAACC GCCAAGGCTGGCAGGATGTG 301 TGCGCCCAAG CCTTTCAAAC CCCCGTCCAT TCCGTTCAGG CAAAACAGTT351 TTTTGAACGC TATTTCACGC CGTGGCAGGT TGCAGGCAAC GGAAGCCTTG 401CCGGTACGGT TACCGGCTAT TACGAGCCGG TGCTGAAGGG CGACGACAGG 451 CGGACGGCACAAGCCCGCTT CCCGATTTAC GGTATTCCCG ACGATTTTAT 501 CTCCGTCCCC CTGCCTGCCGGTTTGCGGAG CGGAAAAGCC CTTGTCCGCA 551 TCAGGCAGAC GGGAAAAAAC AGCGGCACAATCGACAATAC CGGCGGCACA 601 CATACCGCCG ACCTCTCCCA ATTCCCCATC ACTGCGCGCACAACGGCAAT 651 CAAAGGCAGG TTTGAAGGAA GCCGCTTCCT CCCCTACCAC ACGCGCAACC701 AAATCAACGG CGGCGCGCTT GACGGCAAAG CCCCGATACT CGGTTACGCC 751GAAGACCCCG TCGAACTTTT TTTTATGCAC ATCCAAGGCT CGGGCCGTCT 801 GAAAACCCCGTCCGGCAAAT ACATCCGCAT CGGCTATGCC GACAAAAACG 851 AACATCCCTA CGTTTCCATCGGACGCTATA TGGCGGACAA AGGCTACCTC 901 AAGCTCGGGC AGACCTCGAT GCAGGGCATCAAAGCCTATA TGCAGCAAAA 951 CCCGCAACGC CTCGCCGAAG TTTTGGGGCA AAACCCCAGCTATATCTTTT 1001 TCCGAGAGCT TACCGGAAGC AGCAATGACG GCCCTGTCGG CGCACTGGGC1051 ACGCCGCTGA TGGGCGAGTA CGCCGGCGCA GTCGACCGGC ACTACATTAC 1101CTTGGGCGCG CCCTTATTTG TCGCCACCGC CCATCCGGTT ACCCGCAAAG 1151 CCCTCAACCGCCTGATTATG GCGCAGGATA CCGGCAGCGC GATTAAAGGC 1201 GCGGTGCGCG TGGATTATTTTTGGGGATAC GGCGACGAAG CCGGCGAACT 1251 TGCCGGCAAA CAGAAAACCA CGGGATATGTCTGGCAGCTT CTGCCCAACG 1301 GTATGAAGCC CGAATACCGC CCGTAAThis corresponds to the amino acid sequence <SEQ ID 2794; ORF 919.a>:

a919.pep 1 MKKYLFRAAL CGIAAAILAA CQSKSIQTFP QPDTSVINGP DRPVGIPDPA 51GTTVGGGGAV YTVVPHLSLP HWAAQDFAKS LQSFRLGCAN LKNRQGWQDV 101 CAQAFQTPVHSVQAKQFFER YFTPWQVAGN GSLAGTVTGY YEPVLKGDDR 151 RTAQARFPIY GIPDDFISVPLPAGLRSGKA LVRIRQTGKN SGTIDNTGGT 201 HTADLSQFPI TARTTAIKGR FEGSRFLPYHTRNQINGGAL DGKAPILGYA 251 EDPVELFFMH IQGSGRLKTP SGKYIRIGYA DKNEHPYVSIGRYMADKGYL 301 KLGQTSMQGI KAYMQQNPQR LAEVLGQNPS YIFFRELTGS SNDGPVGALG351 TPLMGEYAGA VDRHYITLGA PLFVATAHPV TRKALNRLIM AQDTGSAIKG 401AVRVDYFWGY GDEAGELAGK QKTTGYVWQL LPNGMKPEYR P* m919/a919 98.6% identityin 441 aa overlap        10        20        30        40        50        60 m919.pepMKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAV|||||||||| ||||||||||||||||||||||||||||||||||||||||||||||||| a919MKKYLFRAALCGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAV        10        20        30        40        50        60        70        80        90       100       110       120 m919.pepYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFER||||||||||||||||||||||||||||||||||||||||||||||||||| |||||||| a919YTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSVQAKQFFER        70        80        90       100       110       120       130       140       150       160       170       180 m919.pepYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a919YFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKA       130       140       150       160       170       180       190       200       210       220       230       240 m919.pepLVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGAL||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| a919LVRIRQTGKNSGTIDNTGGTHTADLSQFPITARTTAIKGRFEGSRFLPYHTRNQINGGAL       190       200       210       220       230       240       250       260       270       280       290       300 m919.pepDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a919DGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYL       250       260       270       280       290       300       310       320       330       340       350       360 m919.pepKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGA|||||||||||:||:||||||||||||||||||||||:|||||||||||||||||||||| a919KLGQTSMQGIKAYMQQNPQRLAEVLGQNPSYIFFRELTGSSNDGPVGALGTPLMGEYAGA       310       320       330       340       350       360       370       380       390       400       410       420 m919.pepVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a919VDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGK       370       380       390       400       410       420       430       440 m919.pep QKTTGYVWQLLPNGMKPEYRPX|||||||||||||||||||||| a919 QKTTGYVWQLLPNGMKPEYRPX        430       440

Expression of ORF 919

The primer described in Example 1 for ORF 919 was used to locate andclone ORF 919. This sequence was purified and expressed in E. coli asprovided in FIG. 1 #. The hydrophilicity plots, antigenic index, andamphipatic regions of ORF 919 is provided in FIG. 5 #. The AMPHI programis used to predict putative T-cell epitopes (Gao et al 1989, J. Immunol143:3007; Roberts et al. 1996, AIDS Res Human Retroviruses 12:593;Quakyi et al. 1992, Scand J Immunol Suppl 11:9). The nucleic acidsequence of ORF 919 is provided in Exhibit C #.The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2795>:

g920.seq (partial) 1 ..ccgatgcagc tggttaccga aaaAGGTAAG GAAAACATGATTCAACGCGG 51   CACATACAAC TACCAATACC GCAGCAACCG TCCGGTCAAA GACGGCAGCT101   ACCTCGTTAC CGCCGAATAT CAGCCTACTT TCCGGTCAAA AAACAAAGCA 151  GGCTGGAAAC AGGCTGGCAT CAAAGAAATG CCTGACGCAA GCTATTGCGA 201  ACAAACCCGT ATGTTCGGTA AAAACATTGT CAACGTGGGA CACGAAAGCG 251  CGGACACCGC CATCATCACC AAACCGGTCG GACAAAACTT GGAAATCGTC 301  CCGCTGGACA ATCccgccga caTTCACgtg ggctaacgCt tcaaaGTccg 351  cgttCtgttc cgtGGCgaac cgCTGcccaa tgccACCgtt accgCtacAT 401  TTGacggctt cGAcaccagc gaccgcagca aaacgcacaa Aaccgaagcc 451  caagcctTCT ccgacaccac cgacggcgaa ggcgaagtgg acatcatCCC 501  CTTGCgccaa GGCTTttgga aAgcGAGTGT CGAATAcaaa gccgAtttcc 551  CCGATcaaAG CCTGTGccga AAACAggcgA ACTACaCaac TTtaaccttc 601  caaatcgccc attctCacca tTAaThis corresponds to the amino acid sequence <SEQ ID 2796; ORF 920.ng>:

g920.pep (partial) 1 ..PMQLVTEKGK ENMIQRGTYN YQYRSNRPVK DGSYLVTAEYQPTFRSKNKA 51   GWKQAGIKEM PDASYCEQTR MFGKNIVNVG HESADTAIIT KPVGQNLEIV101   PLDNPADIHV GXRFKVRVLF RGEPLPNATV TATFDGFDTS DRSKTHKTEA 151  QAFSDTTDGE GEVDIIPLRQ GFWKASVEYK ADFPDQSLCR KQANYTTLTF 201   QIAHSHH*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2797>:

m920.seq 1 ATGAAGAAAA CATTGACACT GCTCTCCGTT TCCGCCCTAT TTGCCACATC 51CGCCCACGCC CACCGmGTCT GGGTCGAAAC CGCCCACACG CACGGCGGCG 101 AATACCTTAAAGCCGACTTG GGCTACGGCG AATTTCCCGA ACTCGAACCC 151 ATCGCCAAAG ACCGCCTGCACATCTTCAGC AAACCGATGC AGCTGGTTAC 201 CGAAAAAGGC AAGGAAAACA TGATTCAACGCGGCACATAC AACTACCAGT 251 ACCGAAGCAA CCGTCCCGTT AAGGACGGCA GTTACCTCGTCATCGCCGAA 301 TATCAGCCTA CTTTCTGGTC AAAAwACAAA GCAGGCTGGA AACAGGCGGG351 CATCAAAGAA ATGCCTGACG CAAGCTATTG CGAACAAACC CGAATGTTCG 401GCAAAAACAT CGTCAACGTC GGACACGAAA GCGCGGACAC CGCCATCATC 451 ACCAArCCGGTCGGACAAAA CTTGGAAATC GTCCCGCTGG ACAATCCCGC 501 CAACATTCAC GTAGGCGAACGCTTCAAAGT CCGCGTTCTG TTCCGTGGCG 551 AACCGCTGCC CAATGCCACC GTTACCGCCACCTTTGACGG CTTCGACACC 601 AGCGACCGCA GCAAAACGCA CAAwmCCGAA GCACAGGCTTTCTCCGACAG 651 CACAGACGAC AAAGGCGAAG TGGACATCAT CmCCTTGCGC CAAGGCTTCT701 GGAAAGCCAA TGTCGAACAC AAAACCGACT TCCCCGATCA AAGCGTGTGC 751CAAAAACAGG CGAACTACTC GACTTTAACC TTCCAAATCG GTCATTCGCA 801 CCATTAAThis corresponds to the amino acid sequence <SEQ ID 2798; ORF 920>:

m920.pep 1 MKKTLTLLSV SALFATSAHA HRVWVETAHT HGGEYLKADL GYGEFPELEP 51IAKDRLHIFS KPMQLVTEKG KENMIQRGTY NYQYRSNRPV KDGSYLVIAE 101 YQPTFWSKXKAGWKQAGIKE MPDASYCEQT RMFGKNIVNV GHESADTAII 151 TKPVGQNLEI VPLDNPANIHVGERFKVRVL FRGEPLPNAT VTATFDGFDT 201 SDRSKTHXXE AQAFSDSTDD KGEVDIIXLRQGFWKANVEH KTDFPDQSVC 251 QKQANYSTLT FQIGHSHH*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 920 shows 91.3% identity over a 207 aa overlap with a predicted ORF(ORF 920.ng) from N. gonorrhoeae:

g920/m920                                       10        20        30g920.pep                               PMQLVTEKGKENMIQRGTYNYQYRSNRPVK                              |||||||||||||||||||||||||||||| m920GGEYLKADLGYGEFPELEPIAKDRLHIFSKPMQLVTEKGKENMIQRGTYNYQYRSNRPVK       40        50        60        70        80        90        40        50        60        70        80        90 g920.pepDGSYLVTAEYQPTFRSKNKAGWKQAGIKEMPDASYCEQTRMFGKNIVNVGHESADTAIIT|||||| ||||||| || |||||||||||||||||||||||||||||||||||||||||| m920DGSYLVIAEYQPTFWSKXKAGWKQAGIKEMPDASYCEQTRMFGKNIVNVGHESADTAIIT      100       110       120       130       140       150       100       110       120       130       140       150 g920.pepKPVGQNLEIVPLDNPADIHVGXRFKVRVLFRGEPLPNATVTATFDGFDTSDRSKTHKTEA||||||||||||||||:|||| |||||||||||||||||||||||||||||||||| :|| m920KPVGQNLEIVPLDNPANIHVGERFKVRVLFRGEPLPNATVTATFDGFDTSDRSKTHXXEA      160       170       180       190       200       210       160       170       180       190       200 g920.pepQAFSDTTDGEGEVDIIPLRQGFWKASVEYKADFPDQSLCRKQANYTTLTFQIAHSHHX|||||:|| :|||||| ||||||||:||:|:||||||:|:|||||:||||||:||||| m920QAFSDSTDDKGEVDIIXLRQGFWKANVEHKTDFPDQSVCQKQANYSTLTFQIGHSHHX      220       230       240       250       260The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2799>:

a920.seq 1 TGAAAGAAAA CATTGACACT GCTCGCCGTT TCCGCCCTAT TTGCCGCATC 51CGCCCACGCC CACCGCGTCT GGGTCGAAAC CGCCCACACG CACGGCGGCG 101 AATACCTTAAAGCCGACTTG GGCTACGGCG AATTTCCCGA ACTCGAACCC 151 ATCGCCAAAG ACCGCCTGCACATCTTCAGC AAACCGATGC AGCTGGTTAC 201 CGAAAAAGGC AAGGAAAACA TGATTCAACGCGGCACATAC AACTACCAGT 251 ACCGAAGCAA CCGTCCCGTT AAGGACGGCA GTTACCTCGTCATCGCCGAA 301 TATCAGCCTA CTTTCTGGTC AAAAAACAAA GCAGGCTGGA AACAGGCGGG351 CATCAAACAA ATGCCTGACG CAAGCTATTG CGAACAAACC CGAATGTTCG 401GCAAAAACAT CGTCAACGTC GGACACGAAA GCGCGGACAC CGCCATCATC 451 ACCAAACCGGTCGGACAAAA CTTGGAAATC GTCCCGCTGG ACAATCCCGC 501 CAACATTCAC GTAGGCGAACGCTTCAAAGT CCGCGTTCTG TTCCGTGGCG 551 AACCGCTGCC CAATGCCACC GTTACCGCCACCTTTGACGG CTTCGACACC 601 AGCGACCGCA GCAAAACGCA CAAAACCGAA GCACAGGCTTTCTCCGACAG 651 CACAGACGAC AAAGGCGAAG TGGACATCAT CCCCTTGCGC CAAGGCTTCT701 GGAAAGCCAA TGTCGAACAC AAAGCCGACT TCCCCGATCA AAGCGTGTGC 751CAAAAACAGG CGAACTACTC GACTTTAACC TTCCAAATCG GCCATTCGCA 801 CCATTAAThis corresponds to the amino acid sequence <SEQ ID 2800; ORF 920.a>:

a920.pep 1 *KKTLTLLAV SALFAASAHA HRVWVETAHT HGGEYLKADL GYGEFPELEP 51IAKDRLHIFS KPMQLVTEKG KENMIQRGTY NYQYRSNRPV KDGSYLVIAE 101 YQPTFWSKNKAGWKQAGIKQ MPDASYCEQT RMFGKNIVNV GHESADTAII 151 TKPVGQNLEI VPLDNPANIHVGERFKVRVL FRGEPLPNAT VTATFDGFDT 201 SDRSKTHKTE AQAFSDSTDD KGEVDIIPLRQGFWKANVEH KADFPDQSVC 251 QKQANYSTLT FQIGHSHH* m920/a920 97.0% identityin 267 aa overlap        10        20        30        40        50        60 m920.pepMKKTLTLLSVSALFATSAHAHRVWVETAHTHGGEYLKADLGYGEFPELEPIAKDRLHIFS |||||||:||||||:|||||||||||||||||||||||||||||||||||||||||||| a920XKKTLTLLAVSALFAASAHAHRVWVETAHTHGGEYLKADLGYGEFPELEPIAKDRLHIFS        10        20        30        40        50        60        70        80        90       100       110       120 m920.pepKPMQLVTEKGKENMIQRGTYNYQYRSNRPVKDGSYLVIAEYQPTFWSKXKAGWKQAGIKE|||||||||||||||||||||||||||||||||||||||||||||||| ||||||||||: a920KPMQLVTEKGKENMIQRGTYNYQYRSNRPVKDGSYLVIAEYQPTFWSKNKAGWKQAGIKQ        70        80        90       100       110       120       130       140       150       160       170       180 m920.pepMPDASYCEQTRMFGKNIVNVGHESADTAIITKPVGQNLEIVPLDNPANIHVGERFKVRVL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a920MPDASYCEQTRMFGKNIVNVGHESADTAIITKPVGQNLEIVPLDNPANIHVGERFKVRVL       130       140       150       160       170       180       190       200       210       220       230       240 m920.pepFRGEPLPNATVTATFDGFDTSDRSKTHXXEAQAFSDSTDDKGEVDIIXLRQGFWKANVEH||||||||||||||||||||||||||| :|||||||||||||||||| |||||||||||| a920FRGEPLPNATVTATFDGFDTSDRSKTHKTEAQAFSDSTDDKGEVDIIPLRQGFWKANVEH       190       200       210       220       230       240       250       260      269 m920.pep KTDFPDQSVCQKQANYSTLTFQIGHSHHX|:||||||||||||||||||||||||||| a920 KADFPDQSVCQKQANYSTLTFQIGHSHHX       250       260The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2801>:

g920-1.seq 1 ATGAAGAAAA CATTGACACT GCTCGCcgtt TcCGCACTAT TTGCCACATc 51cgCaCACCCC CACCgCGTCT GGGTCGAAAC CgccCACACg cAcgGCGGCG 101 AATACCTTAAAGCCGACTTG GGCTACGGCG AATTCCCCGA ACTCGAACCC 151 ATCGccAAAG ACCgccTGCACATCTTCAGC AAACCGATGC AGCTGGTTAC 201 CGAAAAAGGT AAGGAAAACA TGATTCAACGCGGCACATAC AACTACCAAT 251 ACCGCAGCAA CCGTCCCGTC AAAGACGGCA GCTACCTCGTTACCGCCGAA 301 TATCAGCCTA CTTTCCGGTC AAAAAACAAA GCAGGCTGGA AACAGGCTGG351 CATCAAAGAA ATGCCTGACG CAAGCTATTG CGAACAAACC CGTATGTTCG 401GTAAAAACAT TGTCAACGTG GGACACGAAA GCGCGGACAC CGCCATCATC 451 ACCAAACCGGTCGGACAAAA CTTGGAAATC GTCCCGCTGG ACAATCCCGC 501 CAACATTCAC GTAGGCGAACGCTTCAAAGT CCGCGTTCTG TTCCGTGGCG 551 AACCGCTGCC CAATGCCACC GTTACCGCTACATTTGACGG CTTCGACACC 601 AGCGACCGCA GCAAAACGCA CAAAACCGAA GCCCAAGCCTTCTCCGACAC 651 CACCGACGGC AAAGGCGAAG TGGACATCAT CCCCTTGCGC CAAGGCTTTT701 GGAAAGCGAG TGTCGAATAC AAAGCCGATT TCCCCGATCA AAGCCTGTGC 751CAAAAACAGG CGAACTACAC AACTTTAACC TTCCAAATCG GCCATTCTCA 801 CCATTAAThis corresponds to the amino acid sequence <SEQ ID 2802; ORF 920-1.ng>:

g920-1.pep 1 MKKTLTLLAV SALFATSAHP HRVWVETAHT HGGEYLKADL GYGEFPELEP 51IAKDRLHIFS KPMQLVTEKG KENMIQRGTY NYQYRSNRPV KDGSYLVTAE 101 YQPTFRSKNKAGWKQAGIKE MPDASYCEQT RMFGKNIVNV GHESADTAII 151 TKPVGQNLEI VPLDNPANIHVGERFKVRVL FRGEPLPNAT VTATFDGFDT 201 SDRSKTHKTE AQAFSDTTDG KGEVDIIPLRQGFWKASVEY KADFPDQSLC 251 QKQANYTTLT FQIGHSHH*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2803>:

m920-1.seq 1 ATGAAGAAAA CATTGACACT GCTCGCCGTT TCCGCCCTAT TTGCCACATC 51CGCCCACGCC CACCGCGTCT GGGTCGAAAC CGCCCACACG CACGGCGGCG 101 AATACCTTAAAGCCGACTTG GGCTACGGCG AATTTCCCGA ACTCGAACCC 151 ATCGCCAAAG ACCGCCTGCACATCTTCAGC AAACCGATGC AGCTGGTTAC 201 CGAAAAAGGC AAGGAAAACA TGATTCAACGCGGCACATAC AACTACCAGT 251 ACCGAAGCAA CCGTCCCGTT AAGGACGGCA GTTACCTCGTCATCGCCGAA 301 TATCAGCCTA CTTTCTGGTC AAAAAACAAA GCAGGCTGGA AACAGGCGGG351 CATCAAAGAA ATGCCTGACG CAAGCTATTG CGAACAAACC CGAATGTTCG 401GCAAAAACAT CGTCAACGTC GGACACGAAA GCGCGGACAC CGCCATCATC 451 ACCAAACCGGTCGGACAAAA CTTGGAAATC GTCCCGCTGG ACAATCCCGC 501 CAACATTCAC GTAGGCGAACGCTTCAAAGT CCGCGTTCTG TTCCGTGGCG 551 AACCGCTGCC CAATGCCACC GTTACCGCCACCTTTGACGG CTTCGACACC 601 AGCGACCGCA GCAAAACGCA CAAAACCGAA GCACAGGCTTTCTCCGACAG 651 CACAGACGAC AAAGGCGAAG TGGACATCAT CCCCTTGCGC CAAGGCTTCT701 GGAAAGCCAA TGTCGAACAC AAAACCGACT TCCCCGATCA AAGCGTGTGC 751CAAAAACAGG CGAACTACTC GACTTTAACC TTCCAAATCG GTCATTCGCA 801 CCATTAAThis corresponds to the amino acid sequence <SEQ ID 2804; ORF 920-1>:

m920-1.pep 1 MKKTLTLLAV SALFATSAHA HRVWVETAHT HGGEYLKADL GYGEFPELEP 51IAKDRLHIFS KPMQLVTEKG KENMIQRGTY NYQYRSNRPV KDGSYLVIAE 101 YQPTFWSKNKAGWKQAGIKE MPDASYCEQT RMFGKNIVNV GHESADTAII 151 TKPVGQNLEI VPLDNPANIHVGERFKVRVL FRGEPLPNAT VTATFDGFDT 201 SDRSKTHKTE AQAFSDSTDD KGEVDIIPLRQGFWKANVEH KTDFPDQSVC 251 QKQANYSTLT FQIGHSHH* m920-1/g920-1 96.3%identity in 268 aa overlap        10        20        30        40        50        60 m920-1.pepMKKTLTLLAVSALFATSAHAHRVWVETAHTHGGEYLKADLGYGEFPELEPIAKDRLHIFS||||||||||||||||||| |||||||||||||||||||||||||||||||||||||||| g920-1MKKTLTLLAVSALFATSAHPHRVWVETAHTHGGEYLKADLGYGEFPELEPIAKDRLHIFS        10        20        30        40        50        60        70        80        90       100       110       120 m920-1.pepKPMQLVTEKGKENMIQRGTYNYQYRSNRPVKDGSYLVIAEYQPTFWSKNKAGWKQAGIKE||||||||||||||||||||||||||||||||||||| ||||||| |||||||||||||| g920-1KPMQLVTEKGKENMIQRGTYNYQYRSNRPVKDGSYLVTAEYQPTFRSKNKAGWKQAGIKE        70        80        90       100       110       120       130       140       150       160       170       180 m920-1.pepMPDASYCEQTRMFGKNIVNVGHESADTAIITKPVGQNLEIVPLDNPANIHVGERFKVRVL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g920-1MPDASYCEQTRMFGKNIVNVGHESADTAIITKPVGQNLEIVPLDNPANIHVGERFKVRVL       130       140       150       160       170       180       190       200       210       220       230       240 m920-1.pepFRGEPLPNATVTATFDGFDTSDRSKTHKTEAQAFSDSTDDKGEVDIIPLRQGFWKANVEH||||||||||||||||||||||||||||||||||||:|| ||||||||||||||||:||: g920-1FRGEPLPNATVTATFDGFDTSDRSKTHKTEAQAFSDTTDGKGEVDIIPLRQGFWKASVEY       190       200       210       220       230       240       250       260      269 m920-1.pep KTDFPDQSVCQKQANYSTLTFQIGHSHHX|:||||||:|||||||:|||||||||||| g920-1 KADFPDQSLCQKQANYTTLTFQIGHSHHX       250       260The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2805>:

a920.seq 1 TGAAAGAAAA CATTGACACT GCTCGCCGTT TCCGCCCTAT TTGCCGCATC 51CGCCCACGCC CACCGCGTCT GGGTCGAAAC CGCCCACACG CACGGCGGCG 101 AATACCTTAAAGCCGACTTG GGCTACGGCG AATTTCCCGA ACTCGAACCC 151 ATCGCCAAAG ACCGCCTGCACATCTTCAGC AAACCGATGC AGCTGGTTAC 201 CGAAAAAGGC AAGGAAAACA TGATTCAACGCGGCACATAC AACTACCAGT 251 ACCGAAGCAA CCGTCCCGTT AAGGACGGCA GTTACCTCGTCATCGCCGAA 301 TATCAGCCTA CTTTCTGGTC AAAAAACAAA GCAGGCTGGA AACAGGCGGG351 CATCAAACAA ATGCCTGACG CAAGCTATTG CGAACAAACC CGAATGTTCG 401GCAAAAACAT CGTCAACGTC GGACACGAAA GCGCGGACAC CGCCATCATC 451 ACCAAACCGGTCGGACAAAA CTTGGAAATC GTCCCGCTGG ACAATCCCGC 501 CAACATTCAC GTAGGCGAACGCTTCAAAGT CCGCGTTCTG TTCCGTGGCG 551 AACCGCTGCC CAATGCCACC GTTACCGCCACCTTTGACGG CTTCGACACC 601 AGCGACCGCA GCAAAACGCA CAAAACCGAA GCACAGGCTTTCTCCGACAG 651 CACAGACGAC AAAGGCGAAG TGGACATCAT CCCCTTGCGC CAAGGCTTCT701 GGAAAGCCAA TGTCGAACAC AAAGCCGACT TCCCCGATCA AAGCGTGTGC 751CAAAAACAGG CGAACTACTC GACTTTAACC TTCCAAATCG GCCATTCGCA 801 CCATTAAThis corresponds to the amino acid sequence <SEQ ID 2806; ORF 920-1.a>:

a920.pep 1 *KKTLTLLAV SALFAASAHA HRVWVETAHT HGGEYLKADL GYGEFPELEP 51IAKDRLHIFS KPMQLVTEKG KENMIQRGTY NYQYRSNRPV KDGSYLVIAE 101 YQPTFWSKNKAGWKQAGIKQ MPDASYCEQT RMFGKNIVNV GHESADTAII 151 TKPVGQNLEI VPLDNPANIHVGERFKVRVL FRGEPLPNAT VTATFDGFDT 201 SDRSKTHKTE AQAFSDSTDD KGEVDIIPLRQGFWKANVEH KADFPDQSVC 251 QKQANYSTLT FQIGHSHH* m920-1/a920 98.9%identity in 267 aa overlap        10        20        30        40        50        60 m920-1.pepMKKTLTLLAVSALFATSAHAHRVWVETAHTHGGEYLKADLGYGEFPELEPIAKDRLHIFS ||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||| a920XKKTLTLLAVSALFAASAHAHRVWVETAHTHGGEYLKADLGYGEFPELEPIAKDRLHIFS        10        20        30        40        50        60        70        80        90       100       110       120 m920-1.pepKPMQLVTEKGKENMIQRGTYNYQYRSNRPVKDGSYLVIAEYQPTFWSKNKAGWKQAGIKE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||: a920KPMQLVTEKGKENMIQRGTYNYQYRSNRPVKDGSYLVIAEYQPTFWSKNKAGWKQAGIKQ        70        80        90       100       110       120       130       140       150       160       170       180 m920-1.pepMPDASYCEQTRMFGKNIVNVGHESADTAIITKPVGQNLEIVPLDNPANIHVGERFKVRVL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a920MPDASYCEQTRMFGKNIVNVGHESADTAIITKPVGQNLEIVPLDNPANIHVGERFKVRVL       130       140       150       160       170       180       190       200       210       220       230       240 m920-1.pepFRGEPLPNATVTATFDGFDTSDRSKTHKTEAQAFSDSTDDKGEVDIIPLRQGFWKANVEH|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a920FRGEPLPNATVTATFDGFDTSDRSKTHKTEAQAFSDSTDDKGEVDIIPLRQGFWKANVEH       190       200       210       220       230       240       250       260      269 m920-1.pep KTDFPDQSVCQKQANYSTLTFQIGHSHHX|:||||||||||||||||||||||||||| a920 KADFPDQSVCQKQANYSTLTFQIGHSHHX       250       260The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 2807>:

g921.seq 1 ATGAAAAAAT ACCTTATCCC TCTTTCCATT GCGGCAGTCC TTTCCGggtG 51Ccagtctatt tatGtgccca cattgacggA aatccccgTg aatcccatca 101 ataCCgtcaaaacggaagCA CCTGCAAAAG GTTTTCGCCT CGCCCCTTCG 151 CATTGGGCGG ATGTTGCCAAAATCAGCGAT GAAGCGACGC GCTTGGGCTA 201 TCAGGTGGGT ATCGGTAAAA TGACCAAGGTTCAGGcgGCG CAATATCTGA 251 ACAACTTCAG AAAACGCCTG GTCGGACGCA ATGCCGTCGATGACAGTATG 301 TATGAAATCT ACCTGCGTTC GGCGGTAGAC AGCCAGCGCG GCGAAATCAA351 TACGGAACAG TCCAAGCTGT ATATCGAGAA TGCCTTGCGC GGCTGGCAGC 401AGCGTtggAA AAATATGGAT GCCAAACCCG ATAATCCCGC ATTTACCAAC 451 TTTTTGATGGAAGTGATGAA GATGCAGCCC TTGAAATGAThis corresponds to the amino acid sequence <SEQ ID 2808; ORF 921.ng>:

g921.pep 1 MKKYLIPLSI AAVLSGCQSI YVPTLTEIPV NPINTVKTEA PAKGFRLAPS 51HWADVAKISD EATRLGYQVG IGKMTKVQAA QYLNNFRKRL VGRNAVDDSM 101 YEIYLRSAVDSQRGEINTEQ SKLYIENALR GWQQRWKNMD AKPDNPAFTN 151 FLMEVMKMQP LK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2809>:

m921.seq 1 ATGAAAAAAT ACCTTATCCC TCTTTCCATT GCGGCAGTTC TTTCCGGCTG 51CCAGTCTATT TATGTGCCCA CATTGACGGA AATCCCCGTG AATCCTATCA 101 ATACCGTCAAAACGGAAGCA CCTGCAAAAG GTTTCCGCCT TGCCTCTTCG 151 CATTGGACGG ATGTTGCCAAAATCAGCGAT GAAGCGACGC GCTTGGGCTA 201 TCAGGTGGGT ATCGGTAAAA TGACCAAGGTTCAGGCGGCG CAATATCTGA 251 ACAACTTCAG AAAACGCCTG GTCGGACGCA ATGCCGTCGATGACAGTATG 301 TATGAAATCT ACCTGCGTTC GGCGATAGAC AGCCAGCGGG GCGCAATCAA351 TACGGAACAG TCCAAGCTGT ATATCCAGAA TGCCTTGCGC GGCTGGCAGC 401AGCGTTGGAA AAATATGGAT GTCAAACCCA ACAACCCCGC ATTTACCAAC 451 TTTTTGATGGAAGTGATGAA GATGCAGCCC TTGAAATGAThis corresponds to the amino acid sequence <SEQ ID 2810; ORF 921>:

m921.pep 1 MKKYLIPLSI AAVLSGCQSI YVPTLTEIPV NPINTVKTEA PAKGFRLASS 51HWTDVAKISD EATRLGYQVG IGKMTKVQAA QYLNNFRKRL VGRNAVDDSM 101 YEIYLRSAIDSQRGAINTEQ SKLYIQNALR GWQQRWKNMD VKPNNPAFTN 151 FLMEVMKMQP LK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 921 shows 95.7% identity over a 162 aa overlap with a predicted ORF(ORF 921.ng) from N. gonorrhoeae:

m921/g921         10        20        30        40        50        60m921.pep MKKYLIPLSIAAVLSGCQSIYVPTLTEIPVNPINTVKTEAPAKGFRLASSHWTDVAKISD|||||||||||||||||||||||||||||||||||||||||||||||| |||:||||||| g921MKKYLIPLSIAAVLSGCQSIYVPTLTEIPVNPINTVKTEAPAKGFRLAPSHWADVAKISD        10        20        30        40        50        60        70        80        90       100       110       120 m921.pepEATRLGYQVGIGKMTKVQAAQYLNNFRKRLVGRNAVDDSMYEIYLRSAIDSQRGAINTEQ||||||||||||||||||||||||||||||||||||||||||||||||:||||| ||||| g921EATRLGYQVGIGKMTKVQAAQYLNNFRKRLVGRNAVDDSMYEIYLRSAVDSQRGEINTEQ        70        80        90       100       110       120       130       140       150       160 m921.pepSKLYIQNALRGWQQRWKNMDVKPNNPAFTNFLMEVMKMQPLKX|||||:||||||||||||||:||:||||||||||||||||||| g921SKLYIENALRGWQQRWKNMDAKPDNPAFTNFLMEVMKMQPLKX       130       140       150       160The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2811>:

a921.seq 1 ATGAAAAAAT ACCTTATCCC TCTTTCCATT GTGGCAGTTC TTTCCGGCTG 51CCAGTCTATT TATGTGCCCA CATTGACGGA AATCCCCGTG AATCCTATCA 101 ATACCGTCAAAACGGAAGCA CCTGCAAAAG GTTTCCGCCT TGCCTCTTCG 151 CATTGGACGG ATGTTGCCAAAATCAGCGAT GAAGCGACGC GCTTGGGCTA 201 TCAGGTGGGT ATCGGTAAAA TGACCAAGGTTCAGGCGGCG CAATATCTGA 251 ACAACTTCAG AAAACGCCTG GTCGGACGCA ATGCCGTCGATGACAGTATG 301 TATGAAATCT ACCTGCGTTC GGCGATAGAC AGCCAGCGGG GCGCAATCAA351 TACGGAACAG TCCAAGCTGT ATATCCAGAA TGCCTTGCGC GGCTGGCAGC 401AGCGTTGGAA AAATATGGAT GTCAAACCCA ACAACCCCGC ATTTACCAAC 451 TTTTTGATGGAAGTGATGAA GATGCAGCCC TTGAAATGAThis corresponds to the amino acid sequence <SEQ ID 2812; ORF 921.a>:

a921.pep 1 MKKYLIPLSI VAVLSGCQSI YVPTLTEIPV NPINTVKTEA PAKGFRLASS 51HWTDVAKISD EATRLGYQVG IGKMTKVQAA QYLNNFRKRL VGRNAVDDSM 101 YEIYLRSAIDSQRGAINTEQ SKLYIQNALR GWQQRWKNMD VKPNNPAFTN 151 FLMEVMKMQP LK* m921/a92199.4% identity in 162 aa overlap        10        20        30        40        50        60 m921.pepMKKYLIPLSIAAVLSGCQSIYVPTLTEIPVNPINTVKTEAPAKGFRLASSHWTDVAKISD||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||| a921MKKYLIPLSIVAVLSGCQSIYVPTLTEIPVNPINTVKTEAPAKGFRLASSHWTDVAKISD        10        20        30        40        50        60        70        80        90       100       110       120 m921.pepEATRLGYQVGIGKMTKVQAAQYLNNFRKRLVGRNAVDDSMYEIYLRSAIDSQRGAINTEQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a921EATRLGYQVGIGKMTKVQAAQYLNNFRKRLVGRNAVDDSMYEIYLRSAIDSQRGAINTEQ        70        80        90       100       110       120       130       140       150       160 m921.pepSKLYIQNALRGWQQRWKNMDVKPNNPAFTNFLMEVMKMQPLKX||||||||||||||||||||||||||||||||||||||||||| a921SKLYIQNALRGWQQRWKNMDVKPNNPAFTNFLMEVMKMQPLKX       130       140       150       160The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 2813>:

g922.seq 1 ATGGAAAAGA GAAAAATACT GCCGCTGGCA ATTTGTTTGG CGGCTTTGTC 51TGCCTGTACG GCGATGGAGG CCCGCACACC CCGGGCAAAT GAAGCCCAAG 101 CCCCCCGCGCGGATGAAATG AAAAAAGAAA GCCGCCCCGC GTTTGACGCG 151 GCAGCCGTAC CGGTATCCGACAGCGGGTTT GCCGCCAATG CAAATGTCCG 201 CCGTTTTGTG GACGATGAAG TCGGGAAAGGGGATTTTTCC CAGGCGGAAT 251 GGCAGGATTT TTTTGACAAA GCGGCTTACA AGGCGGACATCGTCAAGATt 301 ATGCACCGAC CCTCCACATC GCGtCCGTGG TATGtgttcc gCacggGAAa351 ttcGGgcagg gcgaaAtttc ACggcgCGCG Caggttttat GcggaaAacc 401gcgcggttat cgatgatgtg gcgCAAAAat acggcgtGCC TGCCGAGCTT 451 ATCGTGGCGATTATCGGGAT TGAAACGAAT TACGGCAAAA ATACGGGCAG 501 TTTCCGTGTG GCGGACGCATTGGCGACTTT AGGCTTTGAT TATCCCCGCC 551 GCGCCGGGTT TTTCCAAAAA GAATTGGTCGAGCTTTTAAA GCTGGCAAAA 601 GAAGAAGGCG GTGATGTTTT CGCCTTTAAG GGCagcTATGCGGGTGCAAT 651 GGGTATGCCG CAATTTATGC CTTCGAGCTA CCGGAAATGG GCGGTGGATT701 ATGAcgggga cggacatCGG GATATAtggg GCAACGTcgg tgatgtcgcg 751gcatcggTTG CCAATTAtat gaagCAGCAC GGTTGGCGCA CgggcggtAA 801 AATGTTGGTGTCGGCGAcgt tggcgccggg tgcggATGTT CAggcAATCA 851 TTGGCGAAAA AACCGCCCTGACGCGGACGG TGGCGGATTT GAaggCGTAc 901 ggcatcatcc ccggggaaaC GCTCGCAGATGATGAAAAGg cgGTTTTGTT 951 CAAACTGGAA ACCGCACCCG GCGTGTTTGA ATATTATTTGGGCTTGAACA 1001 ATTTTTATAC GGTATGGCAG TACAACCACA GCCGGATGTA TGTAACGgcg1051 gtcaggGACA TTGCCAATTC GCTCGGCGGC CCGGGATTGT AaThis corresponds to the amino acid sequence <SEQ ID 2814; ORF 922.ng>:

g922.pep 1 MEKRKILPLA ICLAALSACT AMEARTPRAN EAQAPRADEM KKESRPAFDA 51AAVPVSDSGF AANANVRRFV DDEVGKGDFS QAEWQDFFDK AAYKADIVKI 101 MHRPSTSRPWYVFRTGNSGR AKFHGARRFY AENRAVIDDV AQKYGVPAEL 151 IVAIIGIETN YGKNTGSFRVADALATLGFD YPRRAGFFQK ELVELLKLAK 201 EEGGDVFAFK GSYAGAMGMP QFMPSSYRKWAVDYDGDGHR DIWGNVGDVA 251 ASVANYMKQH GWRTGGKMLV SATLAPGADV QAIIGEKTALTRTVADLKAY 301 GIIPGETLAD DEKAVLFKLE TAPGVFEYYL GLNNFYTVWQ YNHSRMYVTA351 VRDIANSLGG PGL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2815>:

m922.seq 1 ATGAAAAAGA GAAAAATACT GCCGCTGGCA ATTTGTTTGG CGGCTTTGTC 51TGCCTGTACG GCGATGGAGG CACGCCCACC CCGGGCAAAT GAAGCCCAAG 101 CCCCCCGCGCGGTTGAAATG AAAAAAGAAA GCCGCCCCGC GTTTGACGCG 151 GCAGCCGTAT TTGACGCGGCAGCCGTACCG GTATCCGACA GCGGGTTTGC 201 CGCCAATGCA AATGTCCGCC GTTTTGTGGACGATGAAGTC GGGAAAGGGG 251 ATTTTTCCCG GGCGGAATGG CAGGATTTTT TTGACAAAGCGGCTTACAAG 301 GCGGACATCG TCAAGATTAT GCACCGCCCC TCCACATCGC GTCCGTGGTA351 TGTGTTCCGC ACGGGAAATT CGGGCAAGGC GAAATTTCGC GGCGCGCGCC 401GGTTTTATGC GGAAAACCGC GCGCTTATCG ATGATGTGGC GCAAAAATAC 451 GGCGTGCCTGCCGAACTTAT CGTGGCGGTT ATCGGGATTG AAACGAATTA 501 CGGCAAAAAT ACGGGCAGTTTCCGTGTGGC GGACGCATTG GCGACCTTAG 551 GCTTTGATTA CCCCCGCCGC GCCGGGTTTTTCCAAAAAGA ATTGGTCGAG 601 CTTTTAAAGC TGGCAAAAGA AGAAGGCGGC GATGTTTTCGCCTTTAAAGG 651 CAGCTATGCG GGCGCAATGG GGATGCCGCA ATTTATGCCT TCGAGCTACC701 GGAAATGGGC GGTGGATTAT GACGGGGACG GACATCGGGA CATATGGGGC 751AACGTCGGCG ATGTCGCGGC ATCGGTTGCC AATTATATGA AGCAGCACGG 801 TTGGCGCACGGGCGGGAAAA TGCTGGTGTC TGCAACATTG GCGCCGGGTG 851 CGGATGTTCA GGCAATCATTGGCGAAAAAA CCGCCCTGAC GCGGACGGTG 901 GCGGATTTGA AGGCGTACGG CATCATCCCCGGCGAAGAGC TTGCAGATGA 951 TGAAAAGGCG GTTTTGTTCA AACTGGAAAC CGCACCGGGCGTGTTTGAAT 1001 ATTATTTGGG CTTGAACAAT TTTTATACGG TATGGCAGTA CAACCACAGC1051 CGGATGTATG TAACGGCGGT CAGGGACATT GCCAATTCGC TTGGCGGCCC 1101GGGATTGTAAThis corresponds to the amino acid sequence <SEQ ID 2816; ORF 922>:

m922.pep 1 MKKRKILPLA ICLAALSACT AMEARPPRAN EAQAPRAVEM KKESRPAFDA 51AAVFDAAAVP VSDSGFAANA NVRRFVDDEV GKGDFSRAEW QDFFDKAAYK 101 ADIVKIMHRPSTSRPWYVFR TGNSGKAKFR GARRFYAENR ALIDDVAQKY 151 GVPAELIVAV IGIETNYGKNTGSFRVADAL ATLGFDYPRR AGFFQKELVE 201 LLKLAKEEGG DVFAFKGSYA GAMGMPQFMPSSYRKWAVDY DGDGHRDIWG 251 NVGDVAASVA NYMKQHGWRT GGKMLVSATL APGADVQAIIGEKTALTRTV 301 ADLKAYGIIP GEELADDEKA VLFKLETAPG VFEYYLGLNN FYTVWQYNHS351 RMYVTAVRDI ANSLGGPGL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 922 shows 95.9% identity over a 369 aa overlap with a predicted ORF(ORF 922.ng) from N. gonorrhoeae:

m922/g922         10        20        30        40        50        60m922.pep MKKRKILPLAICLAALSACTAMEARPPRANEAQAPRAVEMKKESRPAFDAAAVFDAAAVP|:||||||||||||||||||||||| ||||||||||| |||||||||||||      ||| g922MEKRKILPLAICLAALSACTAMEARTPRANEAQAPRADEMKKESRPAFDAA------AVP        10        20        30        40        50        70        80        90       100       110       120 m922.pepVSDSGFAANANVRRFVDDEVGKGDFSRAEWQDFFDKAAYKADIVKIMHRPSTSRPWYVFR||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||| g922VSDSGFAANANVRRFVDDEVGKGDFSQAEWQDFFDKAAYKADIVKIMHRPSTSRPWYVFR    60        70        80        90       100       110       130       140       150       160       170       180 m922.pepTGNSGKAKFRGARRFYAENRALIDDVAQKYGVPAELIVAVIGIETNYGKNTGSFRVADAL|||||:|||:|||||||||||:|||||||||||||||||:|||||||||||||||||||| g922TGNSGRAKFHGARRFYAENRAVIDDVAQKYGVPAELIVAIIGIETNYGKNTGSFRVADAL   120       130       140       150       160       170       190       200       210       220       230       240 m922.pepATLGFDYPRRAGFFQKELVELLKLAKEEGGDVFAFKGSYAGAMGMPQFMPSSYRKWAVDY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g922ATLGFDYPRRAGFFQKELVELLKLAKEEGGDVFAFKGSYAGAMGMPQFMPSSYRKWAVDY   180       190       200       210       220       230       250       260       270       280       290       300 m922.pepDGDGHRDIWGNVGDVAASVANYMKQHGWRTGGKMLVSATLAPGADVQAIIGEKTALTRTV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g922DGDGHRDIWGNVGDVAASVANYMKQHGWRTGGKMLVSATLAPGADVQAIIGEKTALTRTV   240       250       260       270       280       290       310       320       330       340       350       360 m922.pepADLKAYGIIPGEELADDEKAVLFKLETAPGVFEYYLGLNNFYTVWQYNHSRMYVTAVRDI|||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||| g922ADLKAYGIIPGETLADDEKAVLFKLETAPGVFEYYLGLNNFYTVWQYNHSRMYVTAVRDI   300       310       320       330       340       350        370m922.pep ANSLGGPGLX |||||||||| g922 ANSLGGPGLX    360The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2817>:

a922.seq 1 ATGAAAAACA GAAAAATACT GCCGCTGGCA ATTTGTTTGG CGGCTTTGTC 51TGCCTGTACG GCGATGGAGG CACGCCCGCC CCGGGCAAAT GAAGCCCAAG 101 CCCCCCGCGCGGATGAAATG AAAAAAGAAA GCCGCCCCGC GTTTGACGCG 151 GCAGCCGTAT TTGACGCGGCAGCCGTACCG GTATCCGACA GCGGGTTTGC 201 CGCCAATGCA AATGTCCGCC GTTTTGTGGACGATGAAGTC GGGAAAGGGG 251 ATTTTTCCCG GGCGGAATGG CAGGATTTTT TTGACAAAGCGGCTTACAAG 301 GCGGACATCG TCAAGATTAT GCACCGCCCC TCCACATCGC GTCCGTGGTA351 TGTGTTCCGC ACGGGAAATT CGGGCAAGGC GAAATTTCGC GGCGCGCGCC 401GGTTTTATGC GGAAAACCGC GCGCTTATCG ATGATGTGGC GCAAAAATAC 451 GGCGTGCCTGCCGAACTTAT CGTGGCGGTT ATCGGGATTG AAACGAATTA 501 CGGCAAAAAT ACGGGCAGTTTCCGTGTGGC GGACGCATTG GCGACCTTAG 551 GCTTTGATTA CCCCCGCCGC GCCGGGTTTTTCCAAAAAGA ATTGGTCGAG 601 CTTTTAAAGC TGGCAAAAGA AGAAGGCGGC GATGTTTTCGCCTTTAAAGG 651 CAGCTATGCG GGCGCAATGG GGATGCCGCA ATTTATGCCT TCGAGCTACC701 GGAAATGGGC GGTGGATTAT GACGGGGACG GACATCGGGA CATATGGGGC 751AATGTTGGCG ATGTCGCGGC ATCGATTGCC AATTATATGA AGCAGCACGG 801 TTGGCGCACGGGCGGGAAAA TACTGGTGTC TGCAACATTG GCGCCGGGTG 851 CGGATGTTCA GGCAATCATTGGCGAAAAAA CCGCCCTGAC GCGGACGGTG 901 GCGGATTTGA AGGCGTACGG CATCATCCCCGGCGAAGAGC TTGCCGATGA 951 TGAAAAGGCG GTTTTGTTCA AACTGGAAAC CGCACCCGGCGTGTTTGAAT 1001 ATTATTTGGG CTTGAACAAT TTTTATACGG TATGGCAGTA CAATCACAGT1051 CGGATGTATG TAACGGCGGT CAGGGACATT GCCAATTCGC TTGGCGGCCC 1101GGGATTGTAAThis corresponds to the amino acid sequence <SEQ ID 2818; ORF 922.a>:

a922.pep 1 MKNRKILPLA ICLAALSACT AMEARPPRAN EAQAPRADEM KKESRPAFDA 51AAVFDAAAVP VSDSGFAANA NVRRFVDDEV GKGDFSRAEW QDFFDKAAYK 101 ADIVKIMHRPSTSRPWYVFR TGNSGKAKFR GARRFYAENR ALIDDVAQKY 151 GVPAELIVAV IGIETNYGKNTGSFRVADAL ATLGFDYPRR AGFFQKELVE 201 LLKLAKEEGG DVFAFKGSYA GAMGMPQFMPSSYRKWAVDY DGDGHRDIWG 251 NVGDVAASIA NYMKQHGWRT GGKILVSATL APGADVQAIIGEKTALTRTV 301 ADLKAYGIIP GEELADDEKA VLFKLETAPG VFEYYLGLNN FYTVWQYNHS351 RMYVTAVRDI ANSLGGPGL* m922/a922 98.9% identity in 369 aa overlap        10        20        30        40        50        60 m922.pepMKKRKILPLAICLAALSACTAMEARPPRANEAQAPRAVEMKKESRPAFDAAAVFDAAAVP||:|||||||||||||||||||||||||||||||||| |||||||||||||||||||||| a922MKNRKILPLAICLAALSACTAMEARPPRANEAQAPRADEMKKESRPAFDAAAVFDAAAVP        10        20        30        40        50        60        70        80        90       100       110       120 m922.pepVSDSGFAANANVRRFVDDEVGKGDFSRAEWQDFFDKAAYKADIVKIMHRPSTSRPWYVFR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a922VSDSGFAANANVRRFVDDEVGKGDFSRAEWQDFFDKAAYKADIVKIMHRPSTSRPWYVFR        70        80        90       100       110       120       130       140       150       160       170       180 m922.pepTGNSGKAKFRGARRFYAENRALIDDVAQKYGVPAELIVAVIGIETNYGKNTGSFRVADAL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a922TGNSGKAKFRGARRFYAENRALIDDVAQKYGVPAELIVAVIGIETNYGKNTGSFRVADAL       130       140       150       160       170       180       190       200       210       220       230       240 m922.pepATLGFDYPRRAGFFQKELVELLKLAKEEGGDVFAFKGSYAGAMGMPQFMPSSYRKWAVDY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a922ATLGFDYPRRAGFFQKELVELLKLAKEEGGDVFAFKGSYAGAMGMPQFMPSSYRKWAVDY       190       200       210       220       230       240       250       260       270       280       290       300 m922.pepDGDGHRDIWGNVGDVAASVANYMKQHGWRTGGKMLVSATLAPGADVQAIIGEKTALTRTV||||||||||||||||||:||||||||||||||:|||||||||||||||||||||||||| a922DGDGHRDIWGNVGDVAASIANYMKQHGWRTGGKILVSATLAPGADVQAIIGEKTALTRTV       250       260       270       280       290       300       310       320       330       340       350       360 m922.pepADLKAYGIIPGEELADDEKAVLFKLETAPGVFEYYLGLNNFYTVWQYNHSRMYVTAVRDI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a922ADLKAYGIIPGEELADDEKAVLFKLETAPGVFEYYLGLNNFYIVWQYNHSRMYVTAVRDI       310       320       330       340       350       360        370m922.pep ANSLGGPGLX |||||||||| a922 ANSLGGPGLX        370The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2819>:

g923.seq 1 ATGAAGCGGC AGGCTTTCTT CAAACCGATG GCGTGTGCGG CATTTCTGTC 51CGCCGTTTCG CTGCGCCTCC CCGTATTGGG CGCGTGTTAC GCAATATTGT 101 CCCTCTATGCGTTTGCACTT TACGGCATCG ACAAACGGCG TGCCGTGCGG 151 GGAAAACGCC GCATTCCCGAACACCGCCTG CTCCTGCCTG CCTTGTTCGG 201 CGGTTGGACG GGCGCATACT TGGGTAGTAGGATGTTCAGG CATAAAACGG 251 CGAAAAAGCG TTTTGTTGTG CTGTTCCGTC TGACTGTTTCGGGCAATGTC 301 CTGGCGACCT GCATCCTGAT TGATTATTTC GTTCCGCCCG AACTTTTTGT351 AAAACTCGGG CAACATCTCT GAThis corresponds to the amino acid sequence <SEQ ID 2820; ORF 923.ng>:

g923.pep 1 MKRQAFFKPM ACAAFLSAVS LRLPVLGACY AILSLYAFAL YGIDKRRAVR 51GKRRIPEHRL LLPALFGGWT GAYLGSRMFR HKTAKKRFVV LFRLTVSGNV 101 LATCILIDYFVPPELFVKLG QHL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2821>:

m923.seq 1 ATGAAGCGGC AGGCTTTCTT CAAACTGATG GCGTGTGCGG CATTTCTGTC 51TGCCGTTTCG CTGCGCCTCC CCGTATTGGG CGCGTGTTAC GCAATATTGT 101 CCCTCTATGCGTTTGCACTT TACGGCATCG ACAAACGGTG CGCCATACGG 151 GGGCAACGCC GCATTCCCGAACACCGCCTG CTGCTGCCTG CATTGCTCGG 201 CGGCTGGGTG GGCGCGTATT TCGGCAGCATGACATTCAAA CATAAGACAG 251 CGAAAAAGCG TTTTGTTGTG CTGTTCCGTC TGACTGTTTCAGGTAATGTC 301 TTGGCGACCC TCATCCTGAT TTATAGTGGA TTAAATTTAA ACCAGTACGG351 CGTTGCCTCG CCTTGCCGTA CTATTTGTAC TGTCTGCGGC TTCGTCGCCT 401TGTCCTGATT TTTGTTAATC CACTATAT.T ATTTTGTCCC GCCTGAATTT 451 TTCGTAAAACTCGGGCAGAA TACCTGAThis corresponds to the amino acid sequence <SEQ ID 2822; ORF 923>:

m923.pep 1 MKRQAFFKLM ACAAFLSAVS LRLPVLGACY AILSLYAFAL YGIDKRCAIR 51GQRRIPEHRL LLPALLGGWV GAYFGSMTFK HKTAKKRFVV LFRLTVSGNV 101 LATLILIYSGLNLNQYGVAS PCRTICTVCG FVALS*FLLI HYXYFVPPEF 151 FVKLGQNT*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 923 shows 68.8% identity over a 157 aa overlap with a predicted ORF(ORF 923.ng) from N. gonorrhoeae:

g923/m923         10        20        30        40        50        60g923.pep MKRQAFFKPMACAAFLSAVSLRLPVLGACYAILSLYAFALYGIDKRRAVRGKRRIPEHRL|||||||| ||||||||||||||||||||||||||||||||||||| |:||:|||||||| m923MKRQAFFKLMACAAFLSAVSLRLPVLGACYAILSLYAFALYGIDKRCAIRGQRRIPEHRL        10        20        30        40        50        60        70        80        90       100 g923.pepLLPALFGGWTGAYLGSRMFRHKTAKKRFVVLFRLTVSGNVLATCILID------------|||||:|||:|||:||  |:||||||||||||||||||||||| ||| m923LLPALLGGWVGAYFGSMTFKHKTAKKRFVVLFRLTVSGNVLATLILIYSGLNLNQYGVAS        70        80        90       100       110       120                 110       120 g923.pep------------------YFVPPELFVKLGQHLX                        ||||||:||||||:m923 PCRTICTVCGFVALSXFLLIHYIYFVPPEFFVKLGQNTX       130       140       150The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2823>:

a923.seq 1 ATGAAGCGGC AGGCTTTCTT CAAACTGATG GCGTGTGCGG CATTTCTGTC 51TGCCGTTTCG CTGCGCCTCC CCGTATTGGG CGCGTGTTAC GCAATATTGT 101 CCCTCTATGCGTTTGCACTT TACGGCATCG ACAAACGGCG TGCCGTGCGG 151 GGAAAACGCC GCATTCCCGAACACCGCCTG CTGCTGCCTG CCTTGTTCGG 201 CGGTTGGGCG GGCGCATACT TGGGCAGCAGGATATTCAGG CATAAAACGG 251 CGAAAAAGCG TTTTGTTGTG CTGTTCCGTC TGACTGTTTCGGGCAATGTC 301 CTGGCGACCC TCATCCTGAT TTATAGTGGA TTAAATTTAA ACCAGTACGG351 CGTTGCCTCG CCTTA.GCTC AAAGAGAACG ATTCTCTAAG GTGCTGAAGC 401ACCAAGTGAA TCGGTTCCGT ACTATTTGTA CTGTCTGCGG CTTCGTCGCC 451 TTGTCCTGATTTTTGTTAAT CCACTAT.AT TATTTTGTCC CGCCTGAATT 501 TTTCGTAAAA CTCGGGCAGAATACCTGAThis corresponds to the amino acid sequence <SEQ ID 2824; ORF 923.a>:

a923.pep 1 MKRQAFFKLM ACAAFLSAVS LRLPVLGACY AILSLYAFAL YGIDKRRAVR 51GKRRIPEHRL LLPALFGGWA GAYLGSRIFR HKTAKKRFVV LFRLTVSGNV 101 LATLILIYSGLNLNQYGVAS PXAQRERFSK VLKHQVNRFR TICTVCGFVA 151 LS*FLLIHYX YFVPPEFFVKLGQNT* m923/a923 84.6% identity in 175 aa overlap        10        20        30        40        50        60 m923.pepMKRQAFFKLMACAAFLSAVSLRLPVLGACYAILSLYAFALYGIDKRCAIRGQRRIPEHRL|||||||||||||||||||||||||||||||||||||||||||||| |:||:|||||||| a923MKRQAFFKLMACAAFLSAVSLRLPVLGACYAILSLYAFALYGIDKRRAVRGKRRIPEHRL        10        20        30        40        50        60        70        80        90       100       110       120 m923.pepLLPALLGGWVGAYFGSMTFKHKTAKKRFVVLFRLTVSGNVLATLILIYSGLNLNQYGVAS|||||:|||:|||:||  |:|||||||||||||||||||||||||||||||||||||||| a923LLPALFGGWAGAYLGSRIFRHKTAKKRFVVLFRLTVSGNVLATLILIYSGLNLNQYGVAS        70        80        90       100       110       120                        130       140       150      159 m923.pepPC-----------------RTICTVCGFVALSXFLLIHYXYFVPPEFFVKLGQNTX|                  ||||||||||||||||||||||||||||||||||||| a923PXAQRERFSKVLKHQVNRFRTICTVCGFVALSXFLLIHYXYFVPPEFFVKLGQNTX       130       140       150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2825>:

g925.seq 1 ATGAAACAAA TGCTTTTGGC cgtcggcgtg ggcGCGGTGT TGGCGGGCTG 51CGGCAaggat gcCGGCGGtt acgagggtTA TTGGCGCGAA AAGTCGGACA 101 AAAAagaggGCGTGATTGCC GTCAAAAAAA AAGGCAATTA CTTCCTTAAT 151 AAAATCAACG TGTTTACAGGCAAGGAGGAG TCTTTGCTTT TGTCTGAAAA 201 AGACGGCGCG CTTTCGATAA ACACGGGGATAGGGGAAATC CCGATCAAAC 251 TTTCCGACGA CGGGAAAGAG CTGTATGTCG AACGCAGGCGGTATGTGAAA 301 ACCGATGCGG CGATGAAGGA CAAAATCATC GCCCACCAGA AAAAGTGCGG351 ACAAACGGCA CAGGCATACC TCGACGCGCG AAATGCGTTG CCGTCAAACC 401AAACGTATCA GCAGCGTCAG GCGGCGATCG AGCAATTGAA ACGGCGGTTT 451 GAAGCCGAGTTTGACGAATT GGAAAAAGAA ATCAAATGCA ACGGCAAACC 501 GACATTGTTG TTTTAGThis corresponds to the amino acid sequence <SEQ ID 2826; ORF 925.ng>:

g925.pep 1 MKQMLLAVGV GAVLAGCGKD AGGYEGYWRE KSDKKEGVIA VKKKGNYFLN 51KINVFTGKEE SLLLSEKDGA LSINTGIGEI PIKLSDDGKE LYVERRRYVK 101 TDAAMKDKIIAHQKKCGQTA QAYLDARNAL PSNQTYQQRQ AAIEQLKRRF 151 EAEFDELEKE IKCNGKPTLL F*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2827>:

m925.seq (partial) 1 ATGAAACAAA TGCTTTTAGC CGTCGGCGTG GTGGCGGTGTTGGCGGGCTG 51 CGGCAAGGAT GCCGGCGGTT ACGAGGGTTA TTGGCGCGAA AAGTCGGACA 101AAAAAGAGGG TATGATTGCC GTCAAAAAAG AAAAAGGCAA TTACTTCCTT .......This corresponds to the amino acid sequence <SEQ ID 2828; ORF 925>:

m925.pep (partial) 1 MKQMLLAVGV VAVLAGCGKD AGGYEGYWRE KSDKKEGMIAVKKEKGNYFL..Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 925 shows 94.0% identity over a 50 aa overlap with a predicted ORF(ORF 925.ng) from N. gonorrhoeae:

m925/g925          10        20        30        40        50 m925.pep MKQMLLAVGVVAVLAGCGKDAGGYEGYWREKSDKKEGMIAVKKEKGNYFL |||||||||| ||||||||||||||||||||||||||:||||| |||||| g925 MKQMLLAVGVGAVLAGCGKDAGGYEGYWREKSDKKEGVIAVKK-KGNYFLNKINVFTGKE         10        20        30        40         50 g925 ESLLLSEKDGALSINTGIGEIPIKLSDDGKELYVERRRYVKIDAAMKDKIIAHQKKCGQT60        70        80        90       100       110The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2829>:

g925-1.seq 1 ATGAAACAAA TGCTTTTGGC CGTCGGCGTG GCGGCGGTGT TGGCGGGCTG 51CGGCAAGGAT GCCGGCGGTT ACGAGGGTTA TTGGCGCGAA AAGTCGGACA 101 AAAAAGAGGGCGTGATTGCC GTCAAAAAAA AAGGCAATTA CTTCCTTAAT 151 AAAATCAACG TGTTTACAGGCAAGGAGGAG TCTTTGCTTT TGTCTGAAAA 201 AGACGGCGCG CTTTCGATAA ACACGGGGATAGGGGAAATC CCGATCAAAC 251 TTTCCGACGA CGGGAAAGAG CTGTATGTCG AACGCAGGCGGTATGTGAAA 301 ACCGATGCGG CGATGAAGGA CAAAATCATC GCCCACCAGA AAAAGTGCGG351 ACAAACGGCA CAGGCATACC TCGACGCGCG AAATGCGTTG CCGTCAAACC 401AAACGTATCA GCAGCGTCAG GCGGCGATCG AGCAATTGAA ACGGCGGTTT 451 GAAGCCGAGTTTGACGAATT GGAAAAAGAA ATCAAATGCA ACGGCAAACC 501 GACATTGTTG TTTTAGThis corresponds to the amino acid sequence <SEQ ID 2830; ORF 925-1.ng>:

g925-1.pep 1 MKQMLLAVGV AAVLAGCGKD AGGYEGYWRE KSDKKEGVIA VKKKGNYFLN 51KINVFTGKEE SLLLSEKDGA LSINTGIGEI PIKLSDDGKE LYVERRRYVK 101TDAAMKDKII AHQKKCGQTA QAYLDARNAL PSNQTYQQRQ AAIEQLKRRF 151EAEFDELEKE IKCNGKPTLL F*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2831>:

m925-1.seq 1 ATGAAACAAA TGCTTTTAGC CGTCGGCGTG GTGGCGGTGT TGGCGGGCTG 51CGGCAAGGAT GCCGGCGGTT ACGAGGGTTA TTGGCGCGAA AAGTCGGACA 101AAAAAGAGGG TATGATTGCC GTCAAAAAAG AAAAAGGCAA TTACTTCCTT 151AATAAAATCC ACGTGGTTAC AGGCAAGGAA GAGTCCTTGC TTTTGTCTGA 201AAAAGACGGC GCGCTTTCGA TAAACACAGG GATAGGGGAA ATCCCGATCA 251AACTTTCCGA CGACGGGAAA GAGCTGTATG TCGAACGTAG GCAGTATGTC 301AAAACCGATG CGGCGATGAA GGACAAAATC ATCGCCCATC AGAAAAAGTG 351CGGACAAACA GCACAGGCAT ACCGCGACGC GCGAAATGCG TTGCCGTCAA 401ACCAGACGTA TCAGCAGCAT CTGGCGGCGA TCGAGCAATT GAAACGGCGG 451TTTGAAGCCG AGTTTGACGA ATTGGAAAAA GAAATCAAAT GCAACGGCAG 501AAGCCCGGCA TTGTTGCTTT AGThis corresponds to the amino acid sequence <SEQ ID 2832; ORF 925-1>:

m925-1.pep.. 1 MKQMLLAVGV VAVLAGCGKD AGGYEGYWRE KSDKKEGMIA VKKEKGNYFL 51NKIHVVTGKE ESLLLSEKDG ALSINTGIGE IPIKLSDDGK ELYVERRQYV 101KTDAAMKDKI IAHQKKCGQT AQAYRDARNA LPSNQTYQQH LAAIEQLKRR 151FEAEFDELEK EIKCNGRSPA LLL* m925/g925 92.5% identity in 173 aa overlap          10        20        30        40        50        60m925-1.pep  MKQMLLAVGVVAVLAGCGKDAGGYEGYWREKSDKKEGMIAVKKEKGNYFLNKIHVVTGKE  ||||||||||:||||||||||||||||||||||||||:||||| |||||||||:| |||| g925-1  MKQMLLAVGVAAVLAGCGKDAGGYEGYWREKSDKKEGVIAVKK-KGNYFLNKINVFTGKE          10        20        30        40         50          70        80        90       100       110       120m925-1.pep  ESLLLSEKDGALSINTGIGEIPIKLSDDGKELYVERRQYVKTDAAMKDKIIAHQKKCGQT  |||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||| g925-1  ESLLLSEKDGALSINTGIGEIPIKLSDDGKELYVERRRYVKTDAAMKDKIIAHQKKCGQT 60        70        80        90       100       110         130       140       150       160       170 m925-1.pep  AQAYRDARNALPSNQTYQQHLAAIEQLKRRFEAEFDELEKEIKCNGRSPALLLX   ||||||||||||||||||: |||||||||||||||||||||||||: |:||:| g925-1  AQAYLDARNALPSNQTYQQRQAAIEQLKRRFEAEFDELEKEIKCNGK-PTLLFX120       130       140       150       160        170The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2833>:

a925-1.seq 1 AATAAAATCA ACGTGTTTAC AGGTAAGGAA GAATCTATGC TTTTGTCTGA 51AAAAGACGGC GCGCTTTCGA TAAACACGGG GATAGGGGAA ATCCCGATCA 101AACTTTCCGA CGACGGGAAA GAGCTGTATG TCGAACGCAG GCAGTATGTC 151AAAACCGATG CGGCGATGAA GGACAAAATC ATCGCCCATC AGAAAAAGTG 201CGGACAAACG GCACAGGCAT ATCTCGACGC GCGAAATGCG TTGCCGTCAA 251ACCAGACGTA TCAGCAGCAT CAGGCGGCGA TCGAGCAGTT GAAACGGCGG 301TTTGAAGCCG AGTTTGACGA ATTGGAAAAA GAAATCAAAT GCAACGGCAA 351ACCGACATTG TTGTTTTAGThis corresponds to the amino acid sequence <SEQ ID 2834; ORF 925-1.a>:

a925-1.pep 1 NKINVFTGKE ESMLLSEKDG ALSINTGIGE IPIKLSDDGK ELYVERRQYV 51KTDAAMKDKI IAHQKKCGQT AQAYLDARNA LPSNQTYQQH QAAIEQLKRR 101FEAEFDELEK EIKCNGKPTL LF* a925-1/m925-1 92.7% identity in 123 aa overlap                                      10        20        30 a925-1.pep                              NKINVFTGKEESMLLSEKDGALSINTGIGE                              |||:| ||||||:||||||||||||||||| m925-1AGGYEGYWREKSDKKEGMIAVKKEKGNYFLNKIHVVTGKEESLLLSEKDGALSINTGIGE        30        40        50        60        70        80        40        50        60        70        80        90 a925-1.pepIPIKLSDDGKELYVERRQYVKTDAAMKDKIIAHQKKCGQTAQAYLDARNALPSNQTYQQH|||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||| m925-1IPIKLSDDGKELYVERRQYVKTDAAMKDKIIAHQKKCGQTAQAYRDARNALPSNQTYQQH        90       100       110       120       130       140       100       110        120 a925-1.pepQAAIEQLKRRFEAEFDELEKEIKCNGK-PTLLFX  |||||||||||||||||||||||||: |:||:|m925-1 LAAIEQLKRRFEAEFDELEKEIKCNGRSPALLLX        150       160       170The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2835>:

g926.seq (partial) 1ATGAAACACA CCGTATCCGC ATCGGTCATC CTGCTTTTGA CCGCTTGCGC 51GCAATTACCT CAAAATAACG AAAACCTGTG GCAGCCGTCC GAACACATCA 101GCAGTTTTGC AGCGGAAGGG CGGTTGGCAG TCAAAGCGGA AGGGAAAGGT 151TCGTATGCAA ATTTCGATTG GACATACCAA CCGCCCGTGG AAACCATCAA 201TATCAACACC CCTTTGGGCA GTACGCTCGG ACAGTTGTGT CAAGacAGGG 251ACGGCGCATT GGCAGTGGAC GGCAAAGGAA ATGTCTATCA GGCAGAGGGT 301ACGgaagact tGAGCAGGCA GCTGGTCGGT TTCAAACTGC CAATCCAATA 351TCTGCATATC TGGGCGGAAG GCAGGCGTGT GGCGGGCGCG CCTtaccGCA 401TCCGTTCAGA CGGCATATTG GAACAATAcg GttggACAAT cgggCagaac 451tgcCGACAGT GGGGGGCaag tccgaacgtt gcaactGAa...This corresponds to the amino acid sequence <SEQ ID 2836; ORF 926.ng>:

g926.pep (partial) 1MKHTVSASVI LLLTACAQLP QNNENLWQPS EHISSFAAEG RLAVKAEGKG 51SYANFDWTYQ PPVETININT PLGSTLGQLC QDRDGALAVD GKGNVYQAEG 101TEDLSRQLVG FKLPIQYLHI WAEGRRVAGA PYRIRSDGIL EQYGWTIGQN 151CRQWGASPNV ATE...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2837>:

m926.seq 1 ATGAAACACA CCGTATCCGC ATCGGTCATC CTGCTTTTGA CCGCTTGCGC 51GCAATTACCT CAAAATAACG AAAACCTGTG GCAGCCGTCC GAACACATCA 101GCAGTTTTGC AGCAGAAGGG CGGTTGGCAG TGAAAGCGGA AGGGAAAGGT 151TCGTATGCAA ATTTCGATTG GACATACCAA CCGCCCGTGG AAACCATCAA 201TATCAATACC CCTTTGGGCA GTACGCTCGG GCAGTTGTGT CAAGACAGGG 251ACGGCGCATT GGCAGTGGAC GGCAAAGGAA ATGTCTATCA GGCGGAAAGT 301GCGGAAGAAT TGAGCAGGCA GCTGGTCGGT TTCAAACTGC CAATCCAATA 351TCTGCATATC TGGGCAGATG GCAGGCGTGT GGCGGGCGCG CCTTACCGCA 401TCCTGCCGGA CGGCATATTG GAACAATACG GTTGGACTGT CGGCAGAACC 451GCCGACAGTG GGGGGCAAGT CCGAACGTTG CAACTGAATA ACGGAAATTT 501GAACATCAGG CTGGTTTTCA CCGAAATCGG TATGCCGTCT GAAACCGAAA 551CCCCGGAACG CTGTGCGGCG CGCACGAGAT AAThis corresponds to the amino acid sequence <SEQ ID 2838; ORF 926>:

m926.pep 1 MKHTVSASVI LLLTACAQLP QNNENLWQPS EHISSFAAEG RLAVKAEGKG 51SYANFDWTYQ PPVETININT PLGSTLGQLC QDRDGALAVD GKGNVYQAES 101AEELSRQLVG FKLPIQYLHI WADGRRVAGA PYRILPDGIL EQYGWTVGRT 151ADSGGQVRTL QLNNGNLNIR LVFTEIGMPS ETETPERCAA RTR* g926/m92691.6% identity in 155 aa overlap        10        20        30        40        50        60 g926.pepMKHTVSASVILLLTACAQLPQNNENLWQPSEHISSFAAEGRLAVKAEGKGSYANFDWTYQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m926MKHTVSASVILLLTACAQLPQNNENLWQPSEHISSFAAEGRLAVKAEGKGSYANFDWTYQ        10        20        30        40        50        60        70        80        90       100       110       120 g926.pepPPVETININTPLGSTLGQLCQDRDGALAVDGKGNVYQAEGTEDLSRQLVGFKLPIQYLHI|||||||||||||||||||||||||||||||||||||||::|:||||||||||||||||| m926PPVETININTPLGSTLGQLCQDRDGALAVDGKGNVYQAESAEELSRQLVGFKLPIQYLHI        70        80        90       100       110       120       130       140       150       160 g926.pepWAEGRRVAGAPYRIRSDGILEQYGWTIGQNCRQWGASPNVATE ||:||||||||||| ||||||||||:|::  : | m926WADGRRVAGAPYRILPDGILEQYGWTVGRTADSGGQVRTLQLNNGNLNIRLVFTEIGMPS       130       140       150       160       170       180 a926.seq 1ATGAAACACA CTGTATCCGC ATCGGTCATC CTGCTTTTGA CCGCTTGCGC 51GCAATTACCT CAAAATAACG AAAACCTGTG GCAGCCGTCC GAACACACCC 101GCAGTTTCAC GGCGGAAGGG CGGTTGGCAG TGAAAGCGGA AGGGAAAGGT 151TCGTATGCAA ATTTCGATTG GACATACCAA CCGCCCGTGG AAACCATCAA 201TATCAACACC CCTTTGGGCA GTACGCTCGG GCAGTTGTGT CAAGACAGGG 251ACGGCGCATT GGCAGTGGAC GGCAAAGGAA ATGTCTATCA GGCGGAAAGT 301GCGGAAGAAT TGAGCAGGCA GCTGGTCGGT TTCAAACTGC CAATCCAATA 351TCTGCATATC TGGGCAGATG GCAGGCCTGT GGCGGGCGCG CCTTACCGCA 401TCCTGCCGGA CGGCATATTG GAACAATACG GTTGGACTGT CGGCAGAACC 451GCCGACAGTG GGGGGCAAGT CCGAACGTTG CAACTGAATA ACGGAAATTT 501GAACATCAGG CTGGTTTTCA CCGAGATTGG TATGCCGTCT GAAACCGAAA 551CCCAAGAACA ATGCGCGGCA CGCATACAGT AA a926.pep 1MKHTVSASVI LLLTACAQLP QNNENLWQPS EHTRSFTAEG RLAVKAEGKG 51SYANFDWTYQ PPVETININT PLGSTLGQLC QDRDGALAVD GKGNVYQAES 101AEELSRQLVG FKLPIQYLHI WADGRPVAGA PYRILPDGIL EQYGWTVGRT 151ADSGGQVRTL QLNNGNLNIR LVFTEIGMPS ETETQEQCAA RIQ* m926/a92696.9% identity in 191 aa overlap        10        20        30        40        50        60 m926.pepMKHTVSASVILLLTACAQLPQNNENLWQPSEHISSFAAEGRLAVKAEGKGSYANFDWTYQ||||||||||||||||||||||||||||||||  ||:||||||||||||||||||||||| a926MKHTVSASVILLLTACAQLPQNNENLWQPSEHTRSFTAEGRLAVKAEGKGSYANFDWTYQ        10        20        30        40        50        60        70        80        90       100       110       120 m926.pepPPVETININTPLGSTLGQLCQDRDGALAVDGKGNVYQAESAEELSRQLVGFKLPIQYLHI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a926PPVETININTPLGSTLGQLCQDRDGALAVDGKGNVYQAESAEELSRQLVGFKLPIQYLHI        70        80        90       100       110       120       130       140       150       160       170       180 m926.pepWADGRRVAGAPYRILPDGILEQYGWTVGRTADSGGQVRTLQLNNGNLNIRVFTEIGMPS ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a926WADGRPVAGAPYRILPDGILEQYGWTVGRTADSGGQVRTLQLNNGNLNIRLVFTEIGMPS       130       140       150       160       170       180        190m926.pep ETETPERCAARTRX |||| |:|||| a926 ETETQEQCAARIQX        190The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2839>:

g927.seq 1 atgaaaacct acGCAcAggC ACTCTATacc GCAGCCCTGC TCACCGCCTG 51CAGCCCcgca GCcgatTcaa accaTCCGTC CGGAcAaAAT GCCCCGGCCA 101ATACCGAATC cgacGgaaAA AACATtaccC TGctcaatgc cTcgtacgat 151gtGACACGGT ATTTttacaa agaatacgac cacTtgtttg tcggaaCATA 201CCAATCCGAA CACCCCGGCA CATCCGTCAG CATCCAACAA TCCCACGGCG 251GCTTCAGCAA ACAGGCATTA TCCGTAGCCA ACGGCCTTCA AGCCGATGTC 301GTAACCATGA ACCAATCTTC CGACATCGAC CTGCTCGAAA AAAA.GGACT 351GGTAGAAAAA GGCTGGCAAC AAGCCCTCCC CGATCACGCC GCACCCTACA 401CCAGCACTAT GGTTTTCCTT GTCCGAAAAA ACAACCCcaa ACAGAtccgC 451GATTGGAACG ACCTTGCCAA AGACGGCGTT AACATCGTCA TCGCCAAGAC 501CTCGGGCAAC GGACGCTACG CCTTCCTCGG CGCATACGGT TACGGTCTGA 551AAGCCAACAA CGGcaaCGAG CAGGAAGCCC AAAAACTCGT CGCATCCATC 601CTCAAAAACA CACCCGTTTT TGAAAACGGC GGACGCGc.C CGCCGCCACC 651ACCTTCACAC AACGCAACAT CGGCGACGTA CTCATCACTT TTGAAAACga 701agCcaactac gtCAGCAAAA AACTGAThis corresponds to the amino acid sequence <SEQ ID 2840; ORF 927.ng>:

g927.pep 1 MKTYAQALYT AALLTACSPA ADSNHPSGQN APANTESDGK NITLLNASYD 51VTRYFYKEYD HLFVGTYQSE HPGTSVSIQQ SHGGFSKQAL SVANGLQADV 101VTMNQSSDID LLEKXGLVEK GWQQALPDHA APYTSTMVFL VRKNNPKQIR 151DWNDLAKDGV NIVIAKTSGN GRYAFLGAYG YGLKANNGNE QEAQKLVASI 201LKNTPVFENG GRXPPPPPSH NATSATYSSL LKTKPTTSAK N*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2841>:

m927.seq 1 ATGAAAACCT ACGCACCGGC ACTCTATACC GCAGCCCTGC TCACCGCCTG 51CAGCCCCGCA GCCGATTCAA ACCATCCGTC CGGACAAAAT GCCCCGGCCA 101ATACCGAATC CGACGGAAAA AACATTACCC TGCTCAACGC CTCATACGAT 151GTGGCACGGG ATTTTTACAA AGAATACAAC CCCTTATTTA TCAAAACATA 201CCAATCCGAA CACCCCGGCA CATCCGTCAG CATCCAACAG TCCCACGGCG 251GCTCCAGCAA ACAGGCATTA TCCGTAGCCA ACGGCCTTCA AGCCGATGTC 301GTAACCATGA ACCAATCCTC CGACATCGAC CTGCTCGAAA AAAAAGGACT 351GGTAGAAAAA GGCTGGCAAC AAGCCCTCCC CGACCACGCC GCGCCCTACA 401CCAGCACTAT GGTTTTCCTT GTCCGAAAAA ACAACCCCAA ACAGATCCGC 451GATTGGAACG ACCTTGCCAA AGACGGCGTT AACATCGTCA TCGCCAATCC 501CAAAACCTCG GGCAACGGAC GCTACGCCTT CCTCGGCGCA TACGGTTACG 551GTCTGAAAAC CACCAACGGC AACGAACAGG AAGCCCAAAA ACTCGTCGCA 601TCCATCCTCA AAAACACCCC CGTTTTTGAA AACGGCGGAC GCkCgCCACC 651ACCACCTTCA CACAACGCAA CATCGGCGAC GTACTCATCA CTTTTGAAAA 701CGAAGCCAAC TACGTCAGCr AAAAACtGAThis corresponds to the amino acid sequence <SEQ ID 2842; ORF 927>:

m927.pep 1 MKTYAPALYT AALLTACSPA ADSNHPSGQN APANTESDGK NITLLNASYD 51VARDFYKEYN PLFIKTYQSE HPGTSVSIQQ SHGGSSKQAL SVANGLQADV 101VTMNQSSDID LLEKKGLVEK GWQQALPDHA APYTSTMVFL VRKNNPKQIR 151DWNDLAKDGV NIVIANPKTS GNGRYAFLGA YGYGLKTTNG NEQEAQKLVA 201SILKNTPVFE NGGRXPPPPS HNATSATYSS LLKTKPTTSA KN*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 927 shows 94.2% identity over a 243 aa overlap with a predicted ORF(ORF 927.ng) from N. gonorrhoeae:

g927/m927           10        20        30        40        50        60g927.pep   MKTYAQALYTAALLTACSPAADSNHPSGQNAPANTESDGKNITLLNASYDVTRYFYKEYD  ||||| |||||||||||||||||||||||||||||||||||||||||||||:| |||||: m927  MKTYAPALYTAALLTACSPAADSNHPSGQNAPANTESDGKNITLLNASYDVARDFYKEYN          10        20        30        40        50        60          70        80        90       100       110       120 g927.pep  HLFVGTYQSEHPGTSVSIQQSHGGFSKQALSVANGLQADVVTMNQSSDIDLLEKXGLVEK   ||: ||||||||||||||||||| ||||||||||||||||||||||||||||| ||||| m927  PLFIKTYQSEHPGTSVSIQQSHGGSSKQALSVANGLQADVVTMNQSSDIDLLEKKGLVEK          70        80        90       100       110       120         130       140       150       160         170 g927.pep  GWQQALPDHAAPYTSTMVFLVRKNNPKQIRDWNDLAKDGVNIVIA--KTSGNGRYAFLGA  |||||||||||||||||||||||||||||||||||||||||||||  ||||||||||||| m927  GWQQALPDHAAPYTSTMVFLVRKNNPKQIRDWNDLAKDGVNIVIANPKTSGNGRYAFLGA         130       140       150       160       170       180 180      190       200       210       220       230 g927.pep  YGYGLKANNGNEQEAQKLVASILKNTPVFENGGRXPPPPPSHNATSATYSSLLKTKPTTS  ||||||::||||||||||||||||||||||||||||||| |||||||||||||||||||| m927  YGYGLKTTNGNEQEAQKLVASILKNTPVFENGGRXPPPP-SHNATSATYSSLLKTKPTTS         190       200       210       220       230  240 g927.pep  AKNX   |||| m927   AKNX 240The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2843>:

a927.seq 1 ATGAAAACCT ACGCACCGGC ACTCTATACC GCAGCCCTGC TCAGCGCCTG 51CAGCCCCGCA GCCGATTCAA ACCATCCGTC CGGACAAAAT GCCCCGGCCA 101ATACCGAATC CGACGGAAAA AACATTACCC TGCTCAACGC CTCATACGAT 151GTGGCACGGG ATTTTTACAA AGAATACAAC CCCTTATTTA TCAAAACATA 201CCAATCCGAA CACCCCGGCA CATCCGTCAG CATCCAACAG TCCCACGGCG 251GCTCCAGCAA ACAGGCATTA TCCGTAGCCA ACGGCCTTCA AGCCGATGTC 301GTAACCATGA ACCAATCCTC CGACATCGAC CTGCTCGAAA AAAAAGGACT 351GGTAGAAAAA GGCTGGCAAC AAGCCCTCCC CGACCACGCC GCGCCCTACA 401CCAGCACTAT GGTTTTCCTT GTCCGAAAAA ACAACCCCAA ACAGATCCGC 451GATTGGAACG ACCTTGCCAA AGACGGCGTT AACATCGTCA TCGCCAATCC 501CAAAACCTCG GGCAACGGAC GCTACGCCTT CCTCGGCGCA TACGGTTACG 551GTCTGAAAAC CACCAACGGC AACGAACAGG AAGCCCAAAA ACTCGTCGCA 601TCCATCCTCA AAAACACCCC CGTTTTTGAA AACGGCGGAC GCGCGCCACC 651ACCACCTTCA CACAACGCAA CATCGGCGAC GTACTCATCA CTTTTGAAAA 701CGAAGCCAAC TACGTCAGCA AAAAACTGAThis corresponds to the amino acid sequence <SEQ ID 2844; ORF 927.a>:

a927.pep 1 MKTYAPALYT AALLSACSPA ADSNHPSGQN APANTESDGK NITLLNASYD 51VARDFYKEYN PLFIKTYQSE HPGTSVSIQQ SHGGSSKQAL SVANGLQADV 101 VTMNQSSDIDLLEKKGLVEK GWQQALPDHA APYTSTMVFL VRKNNPKQIR 151 DWNDLAKDGV NIVIANPKTSGNGRYAFLGA YGYGLKTTNG NEQEAQKLVA 201 SILKNTPVFE NGGRAPPPPS HNATSATYSSLLKTKPTTSA KN* m927/a927 99.2% identity in 242 aa overlap        10        20        30        40        50        60 m927.pepMKTYAPALYTAALLTACSPAADSNHPSGQNAPANTESDGKNITLLNASYDVARDFYKEYN||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||| a927MKTYAPALYTAALLSACSPAADSNHPSGQNAPANTESDGKNITLLNASYDVARDFYKEYN        10        20        30        40        50        60        70        80        90       100       110       120 m927.pepPLFIKTYQSEHPGTSVSIQQSHGGSSKQALSVANGLQADVVTMNQSSDIDLLEKKGLVEK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a927PLFIKTYQSEHPGTSVSIQQSHGGSSKQALSVANGLQADVVTMNQSSDIDLLEKKGLVEK        70        80        90       100       110       120       130       140       150       160       170       180 m927.pepGWQQALPDHAAPYTSTMVFLVRKNNPKQIRDWNDLAKDGVNIVIANPKTSGNGRYAFLGA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a927GWQQALPDHAAPYTSTMVFLVRKNNPKQIRDWNDLAKDGVNIVIANPKTSGNGRYAFLGA       130       140       150       160       170       180       190       200       210       220       230       240 m927.pepYGYGLKTTNGNEQEAQKLVASILKNTPVFENGGRXPPPPSHNATSATYSSLLKTKPTTSA|||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||| a927YGYGLKTTNGNEQEAQKLVASILKNTPVFENGGRAPPPPSHNATSATYSSLLKTKPTTSA       190       200       210       220       230       240 m927.pepKNX ||| a927 KNXThe following partial DNA sequence was identified in N.gonorrhoeae <SEQID 2845>:

g929.seq 1 ATGAAATTGG GTTTCAAACC GATACCCCTC GCCATTGCCG CAGTATTGTG 51CGCCCTGGTT TTGGCACTGC CCGTACccga CGGGGTCAAG CCTCAGGCTT 101 GGACGCTGCTGGCTATGTTT GTCGGTGTGA TTGCCGCCAT TATCGGCAAG 151 GTTATGCCGT TGGGCGCGCTGTCGATTATT GCCGTCGGGT TGGTCGCAGT 201 AACCGGCGTA ACCGCCGACA AACCGGGCGCGGCGATGAGC GATGCGTTGA 251 GTGCGTTCGC CAATCCGTTG ATTTGGCTGA TTGCCATCGCAGTTATGATT 301 TCGCGCGGTT TGCTCAAAAC AGGGCTGGGG ATGCGTATCG GATATTTGTT351 TATCGCCGTT TTTGGAAGAA AAAcgctggG CATCGGTTAC AGTCTCGCTC 401TTTCCGAACT GCTGCTGGCT CCCGTTACCC CTTCCAATAC CGCGCGCGGC 451 GGCGGCATTATACATCcgaT TATGCagtcg attgCcggCA GttacggctC 501 caatCCCGCA AAAGGCACagaaggcaagat gggtaAATAT TtggcTTtgg 551 tcaattaTCA TTCcaaTCCC atttcgtcggctAtggctat taCTGcaact 601 gCCCCcaaCC CTTTAATcgt caacttgatt gccGaaaaTttaggcagtag 651 tttccgtCTT TCttgggggg cgTGGGcgtg ggcaaTGGCT Gttcccggcg701 ttatcgcctt TTtcgTTATG CCTTTGATTT TATATTTTTT GTATCCGCCT 751GAAATTAAAG AAACGCCCAA TGCTGttcAA TTTGCCAAAG ACCGTCTGAG 801 CGAGATGGGTAAAATGtcgg CAGACGAAAT CATTATGGCG GTCATTTTCG 851 GTATCTTGCT GCTGTTGTGGGCAGATGTTC CCGCCCTTAT TACCGGCAAT 901 CACGCTTTTA GTATCAacgc caccGCCACCGCATTTATCG GATTAAGCCT 951 GCTTTTGCTT TCCGGTGTAT TGACTTGGGA CGATGTTTTGAAAGAAAAAA 1001 GCGCGTGGGA TACGATTATT TGGTTTGGCG CATTGATTAT GATGGCCGCA1051 TTTTTaAATA AActcggact gattaaatGG TTCTCCGGAG TGTTGGCGGA 1101AagtgtcggC GGTTTGGGCG TTAGCGGCAC GGCTGCGGGC GTAATCCTCG 1151 TGCTTGCttaTATGTATGCG CATTATATGT TTGCCAGTAC TACTGCACAT 1201 ATTACCGCTA TGTTCGGCGCATTTCTCGCT GCTGCCGTTT CACTGAATGC 1251 CCCGGCGATG CCGACTGCGC TGATGATGGCGGCCGCATCC AACATTATGA 1301 TGACCCTCAC TCATTATGCG ACCGGTACTT CACCTGTGATTTTCGGCTCG 1351 GGCTACACCA CAATGGGAGA ATGGTGGAAG GCGGGTTTTA TCATGAGCGT1401 AGTCAATTTT CTGATTTTTT CCGTTATCGG CAGCATTTGG TGGAAAGTTC 1451TGGGATATTG GTAAThis corresponds to the amino acid sequence <SEQ ID 2846; ORF 929.ng>:

g929.pep 1 MKLGFKPIPL AIAAVLCALV LALPVPDGVK PQAWTLLAMF VGVIAAIIGK 51VMPLGALSII AVGLVAVTGV TADKPGAAMS DALSAFANPL IWLIAIAVMI 101 SRGLLKTGLGMRIGYLFIAV FGRKTLGIGY SLALSELLLA PVTPSNTARG 151 GGIIHPIMQS IAGSYGSNPAKGTEGKMGKY LALVNYHSNP ISSAMAITAT 201 APNPLIVNLI AENLGSSFRLSWGAWAWAMA VPGVIAFFVM PLILYFLYPP 251 EIKETPNAVQ FAKDRLSEMGKMSADEIIMA VIFGILLLLW ADVPALITGN 301 HAFSINATAT AFIGLSLLLL SGVLTWDDVLKEKSAWDTII WFGALIMMAA 351 FLNKLGLIKW FSGVLAESVG GLGVSGTAAG VILVLAYMYAHYMFASTTAH 401 ITAMFGAFLA AAVSLNAPAM PTALMMAAAS NIMMTLTHYA TGTSPVIFGS451 GYTTMGEWWK AGFIMSVVNF LIFSVIGSIW WKVLGYW*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2847>:

m929.seq 1 ATGAAATTGG GTTTCAAACC GATACCCCTC GCCATTGCCG CAGTATTGTG 51CGCCCTGGTT TTGGCACTGC CCGTACCCGA CGGGGTCAAG CCTCAGGCTT 101 GGACGCTGCTGGCCATGTTT GTCGGTGTGA TTGCCGCCAT TATCGGCAAG 151 GCCATGCCGT TGGGCGCGCTGTCGATTATT GCCGTCGGGT TGGTCGCAGT 201 AACCGGCGTA ACCGCCGACA AACCGGGCGCGGCGATGAGC GATGCGTTGA 251 GTGCGTTCGC CAATCCGTTG ATTTGGCTGA TTGCCATCGCAGTTATGATT 301 TCGCGCGGTT TGCTCAAAAC AGGGCTGGGG ATGCGTATCG GATATTTGTT351 TATCGCCGTT TTTGGAAGAA AAACGCTGGG CATCGGTTAC AGTCTCGCTC 401TTTCCGAACT GCTGCTGGCT CCCGTTACCC CTTCCAATAC CGCGCGCGGC 451 GGCGGCATTATACATCCGAT TATGCAGTCG ATTGCCGGCA GTTACGGCTC 501 CAATCCCGCA AAAGGCACAGAAGGCAAGAT GGGTAAATAT TTGGCTTTGG 551 TCAACTATCA TTCCAATCCC ATTTCGTCGGCTATGTTTAT TACTGCAACT 601 GCCCCCAACC CTTTAATCGT CAACTTGATT GCCGAAAATTTAGGCAGTAG 651 TTTCCGTCTT TCTTGGGGGG CGTGGGCGTG GGCAATGGCT GTTCCCGGCG701 TTATCGCCTT TTTCGTTATG CCTTTGATTT TATATTTwyT GTATCCGCCT 751GAAATTAAAG AAACGCCCAA TGCCGTTCAA TTTGCCAAAG ACCGTCTGAG 801 GGAGATGGGTAAAATGTCGG CAGACGAAAT CATTATGGCG GTCATTTTCG 851 GTATCTTGCT GCTGTTGTGGGCAGATGTTC CCGCCCTTAT TACCGGCAAT 901 CACGCTTTTA GTATCAACGC CACCGCCACCGCATTTATCG GATTAAGCCT 951 GCTTTTGCTT TCCGGTGTAT TGACTTGGGA CGATGTTTTGAAAGAAAAAA 1001 GCGCGTGGGA TACGATTATT TGGTTTGGCG CATTGATTAT GATGGCCGCA1051 TTTTTAAATA AACTCGGACT GATTAAATGG TTCTCCGGAG TGTTGGCGGA 1101AAGTGTCGGC GGTTTGGGCG TTAGCGGCAC GGCTGCGGGC GTAATCCTCG 1151 TGCTTGCTTATATGTATGCG CATTATATGT TTGCCAGTAC TACTGCACAT 1201 ATTACCGCTA TGTTCGGCGCATTTTTCGCT GCTGCCGTTT CACTGAATGC 1251 CCCGGCGATG CCGACCGCGC TGATGATGGCGgCCGCATCC AACATTATGA 1301 TGACCCTCAC TCATTATGCG ACCGGTACTT CGCCTGTGATTTTCGGTTCG 1351 GGCTACACCA CAATGGGAGA ATGGTGGAAG GCGGGTTTTA TCATGAGCGT1401 AGTCAATTTT CTGATTTTTT TCGTTATCGG CAGCATTTGG TGGAAAGTTC 1451TGGGGTATTG GTAAThis corresponds to the amino acid sequence <SEQ ID 2848; ORF 929>:

m929.pep 1 MKLGFKPIPL AIAAVLCALV LALPVPDGVK PQAWTLLAMF VGVIAAIIGK 51AMPLGALSII AVGLVAVTGV TADKPGAAMS DALSAFANPL IWLIAIAVMI 101 SRGLLKTGLGMRIGYLFIAV FGRKTLGIGY SLALSELLLA PVTPSNTARG 151 GGIIHPIMQS IAGSYGSNPAKGTEGKMGKY LALVNYHSNP ISSAMFITAT 201 APNPLIVNLI AENLGSSFRLSWGAWAWAMA VPGVIAFFVM PLILYXLYPP 251 EIKETPNAVQ FAKDRLREMGKMSADEIIMA VIFGILLLLW ADVPALITGN 301 HAFSINATAT AFIGLSLLLL SGVLTWDDVLKEKSAWDTII WFGALIMMAA 351 FLNKLGLIKW FSGVLAESVG GLGVSGTAAG VILVLAYMYAHYMFASTTAH 401 ITAMFGAFFA AAVSLNAPAM PTALMMAAAS NIMMTLTHYA TGTSPVIFGS451 GYTTMGEWWK AGFIMSVVNF LIFFVIGSIW WKVLGYW*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 929 shows 98.8% identity over a 487 aa overlap with a predicted ORF(ORF 929.ng) from N. gonorrhoeae:

g929/m929         10        20        30        40        50        60g929.pep MKLGFKPIPLAIAAVLCALVLALPVPDGVKPQAWTLLAMFVGVIAAIIGKVMPLGALSII||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| m929MKLGFKPIPLAIAAVLCALVLALPVPDGVKPQAWTLLAMFVGVIAAIIGKAMPLGALSII        10        20        30        40        50        60        70        80        90       100       110       120 g929.pepAVGLVAVTGVTADKPGAAMSDALSAFANPLIWLIAIAVMISRGLLKTGLGMRIGYLFIAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m929AVGLVAVTGVTADKPGAAMSDALSAFANPLIWLIAIAVMISRGLLKTGLGMRIGYLFIAV        70        80        90       100       110       120       130       140       150       160       170       180 g929.pepFGRKTLGIGYSLALSELLLAPVTPSNTARGGGIIHPIMQSIAGSYGSNPAKGTEGKMGKY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m929FGRKTLGIGYSLALSELLLAPVTPSNTARGGGIIHPIMQSIAGSYGSNPAKGTEGKMGKY       130       140       150       160       170       180       190       200       210       220       230       240 g929.pepLALVNYHSNPISSAMAITATAPNPLIVNLIAENLGSSFRLSWGAWAWAMAVPGVIAFFVM||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| m929LALVNYHSNPISSAMFITATAPNPLIVNLIAENLGSSFRLSWGAWAWAMAVPGVIAFFVM       190       200       210       220       230       240       250       260       270       280       290       300 g929.pepPLILYFLYPPEIKETPNAVQFAKDRLSEMGKMSADEIIMAVIFGILLLLWADVPALITGN||||| |||||||||||||||||||| ||||||||||||||||||||||||||||||||| m929PLILYXLYPPEIKETPNAVQFAKDRLREMGKMSADEIIMAVIFGILLLLWADVPALITGN       250       260       270       280       290       300       310       320       330       340       350       360 g929.pepHAFSINATATAFIGLSLLLLSGVLTWDDVLKEKSAWDTIIWFGALIMMAAFLNKLGLIKW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m929HAFSINATATAFIGLSLLLLSGVLTWDDVLKEKSAWDTIIWFGALIMMAAFLNKLGLIKW       310       320       330       340       350       360       370       380       390       400       410       420 g929.pepFSGVLAESVGGLGVSGTAAGVILVLAYMYAHYMFASTTAHITAMFGAFLAAAVSLNAPAM||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||| m929FSGVLAESVGGLGVSGTAAGVILVLAYMYAHYMFASTTAHITAMFGAFFAAAVSLNAPAM       370       380       390       400       410       420       430       440       450       460       470       480 g929.pepPTALMMAAASNIMMTLTHYATGTSPVIFGSGYTTMGEWWKAGFIMSVVNFLIFSVIGSIW||||||||||||||||||||||||||||||||||||||||||||||||||||| |||||| m929PTALMMAAASNIMMTLTHYATGTSPVIFGSGYTTMGEWWKAGFIMSVVNFLIFFVIGSIW       430       440       450       460       470       480 g929.pepWKVLGYWX |||||||| m929 WKVLGYWXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2849>:

a929.seq 1 ATGAAATTGG GTTTCAAACC GATACCCCTC GCCATTGCCG CAGTATTGTG 51CGCCTTGGTT TTGGCACTGC CCGTACCCGA CGGGGTCAAG CCTCAGGCTT 101 GGACGCTGCTGGCCATGTTT ATCGGTGTGA TTGCCGCCAT TATCGGCAAG 151 GCCATGCCGT TGGGTGCGCTGTCGATTATT GCCGTCGGGT TGGTCGCAGT 201 AACCGGCGTA ACCGCCGACA AACCGGGTGCGGCGATGAGC GATGCGTTGA 251 GTGCGTTCGC CAATCCGTTG ATTTGGCTGA TTGCCATCGCAGTTATGATT 301 TCGCGCGGTT TGCTCAAAAC AGGGCTGGGG ATGCGTATCG GATATTTGTT351 TATCGCCGTT TTTGGAAGAA AAACGCTGGG CATCGGTTAC AGTCTCGCTC 401TTTCCGAACT GCTGCTGGCT CCCGTTACCC CTTCCAATAC CGCGCGCGGC 451 GGCGGCATTATACATCCGAT TATGCAGTCG ATTGCCGGCA GTTACGGCTC 501 CAATCCCGCA AAAGGCACAGAAGGCAAGAT GGGTAAATAT TTGGCTTTGG 551 TCAACTATCA TTCCAATCCC ATTTCGTCGGCTATGTTTAT TACTGCAACT 601 GCCCCCAACC CTTTAATCGT CAACTTGATT GCCGAAAATTTAGGCAGTAG 651 TTTCCGTCTT TCTTGGGGGG CGTGGGCGTG GGCAATGGCT GTTCCCGGCG701 TTATCGCCTT TTTCGTTATG CCTTTGATTT TATATTTTTT GTATCCGCCT 751GAAATTAAAG AAACGCCCAA TGCCGTTCAA TTTGCCAAAG ACCGTCTGAG 801 GGAGATGGGTAAAATGTCGG CAGACGAAAT CATTATGGCG GTCATTTTCG 851 GTATCTTGTT GCTGTTGTGGGCAGATGTTC CCGCCCTTAT TACCGGCAAT 901 CACGCTTTTA GTATCAACGC CACCGCCACCGCATTTATCG GATTAAGCCT 951 GCTTTTGCTT TCCGGTGTAT TGACTTGGGA CGATGTTTTGAAAGAAAAAA 1001 GCGCGTGGGA TACGATTATT TGGTTTGGCG CATTGATTAT GATGGCCGCA1051 TTTTTAAATA AACTCGGACT GATTAAATGG TTCTCCGGAG TGTTGGCGGA 1101AAGTGTCGGC GGTTTGGGCG TTAGCGGCAC GGCTGCGGGC GTAATCCTCG 1151 TGCTTGCTTATATGTATGCG CATTATATGT TTGCCAGTAC TACTGCACAT 1201 ATTACCGCTA TGTTCGGCGCATTTTTCGCT GCTGCCGTTT CACTGAATGC 1251 CCCGGCGATG CCGACCGCGC TGATGATGGCGGCCGCATCT AACATTATGA 1301 TGACCCTCAC TCATTATGCG ACCGGTACTT CGCCTGTGATTTTCGGTTCG 1351 GGCTACACCA CAATGGGAGA ATGGTGGAAG GCGGGTTTTA TCATGAGCGT1401 AGTCAATTTT CTGATTTTTT TCGTTATCGG CAGCATTTGG TGGAAAGTTC 1451TGGGGTATTG GTAAThis corresponds to the amino acid sequence <SEQ ID 2850; ORF 929.a>:

a929.pep 1 MKLGFKPIPL AIAAVLCALV LALPVPDGVK PQAWTLLAMF IGVIAAIIGK 51AMPLGALSII AVGLVAVTGV TADKPGAAMS DALSAFANPL IWLIAIAVMI 101 SRGLLKTGLGMRIGYLFIAV FGRKTLGIGY SLALSELLLA PVTPSNTARG 151 GGIIHPIMQS IAGSYGSNPAKGTEGKMGKY LALVNYHSNP ISSAMFITAT 201 APNPLIVNLI AENLGSSFRLSWGAWAWAMA VPGVIAFFVM PLILYFLYPP 251 EIKETPNAVQ FAKDRLREMGKMSADEIIMA VIFGILLLLW ADVPALITGN 301 HAFSINATAT AFIGLSLLLL SGVLTWDDVLKEKSAWDTII WFGALIMMAA 351 FLNKLGLIKW FSGVLAESVG GLGVSGTAAG VILVLAYMYAHYMFASTTAH 401 ITAMFGAFFA AAVSLNAPAM PTALMMAAAS NIMMTLTHYA TGTSPVIFGS451 GYTTMGEWWK AGFIMSVVNF LIFFVIGSIW WKVLGYW* m929/a929 99.6% identityin 487 aa overlap        10        20        30        40        50        60 m929.pepMKLGFKPIPLAIAAVLCALVLALPVPDGVKPQAWTLLAMFVGVIAAIIGKAMPLGALSII||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||| a929MKLGFKPIPLAIAAVLCALVLALPVPDGVKPQAWTLLAMFIGVIAAIIGKAMPLGALSII        10        20        30        40        50        60        70        80        90       100       110       120 m929.pepAVGLVAVTGVTADKPGAAMSDALSAFANPLIWLIAIAVMISRGLLKTGLGMRIGYLFIAV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a929AVGLVAVTGVTADKPGAAMSDALSAFANPLIWLIAIAVMISRGLLKTGLGMRIGYLFIAV        70        80        90       100       110       120       130       140       150       160       170       180 m929.pepFGRKTLGIGYSLALSELLLAPVTPSNTARGGGIIHPIMQSIAGSYGSNPAKGTEGKMGKY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a929FGRKTLGIGYSLALSELLLAPVTPSNTARGGGIIHPIMQSIAGSYGSNPAKGTEGKMGKY       130       140       150       160       170       180       190       200       210       220       230       240 m929.pepLALVNYHSNPISSAMFITATAPNPLIVNLIAENLGSSFRLSWGAWAWAMAVPGVIAFFVM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a929LALVNYHSNPISSAMFITATAPNPLIVNLIAENLGSSFRLSWGAWAWAMAVPGVIAFFVM       190       200       210       220       230       240       250       260       270       280       290       300 m929.pepPLILYXLYPPEIKETPNAVQFAKDRLREMGKMSADEIIMAVIFGILLLLWADVPALITGN||||| |||||||||||||||||||||||||||||||||||||||||||||||||||||| a929PLILYFLYPPEIKETPNAVQFAKDRLREMGKMSADEIIMAVIFGILLLLWADVPALITGN       250       260       270       280       290       300       310       320       330       340       350       360 m929.pepHAFSINATATAFIGLSLLLLSGVLTWDDVLKEKSAWDTIIWFGALIMMAAFLNKLGLIKW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a929HAFSINATATAFIGLSLLLLSGVLTWDDVLKEKSAWDTIIWFGALIMMAAFLNKLGLIKW       310       320       330       340       350       360       370       380       390       400       410       420 m929.pepFSGVLAESVGGLGVSGTAAGVILVLAYMYAHYMFASTTAHITAMFGAFFAAAVSLNAPAM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a929FSGVLAESVGGLGVSGTAAGVILVLAYMYAHYMFASTTAHITAMFGAFFAAAVSLNAPAM       370       380       390       400       410       420       430       440       450       460       470       480 m929.pepPTALMMAAASNIMMTLTHYATGTSPVIFGSGYTTMGEWWKAGFIMSVVNFLIFFVIGSIW|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a929PTALMMAAASNIMMTLTHYATGTSPVIFGSGYTTMGEWWKAGFIMSVVNFLIFFVIGSIW       430       440       450       460       470       480 m929.pepWKVLGYWX |||||||| a929 WKVLGYWX

g930.seq not found yet

g930.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2851>:

m930.seq 1 ATGAAACTTC CTTTATCCTA TTTGCCTAAT ATTCGCTTTT TGTCTTGGTG 51CTGCTTATTG GCAGGTATCA TTGCTCCTGC TACTTTGTTG GCCTCCCCCA 101 ACCCTGCCGAAATCCGTATG CAGCAAGATA TTCAGCAACG CCAACGCGAA 151 GAGCAGTTGC GCCAAACCATGCAGCCTGAA AGCGATGTGC GTTTGCATCA 201 AAAAAACACG GGGGAAACGG TTAATCAGTTGATGGGCGAT GACAGCAGCC 251 AACCGTGTTT TGCCATTAAC GAAtGGGTGT TGGAAGGCGAACACCATGCT 301 CGGTTTCAGT TTGCCCTAAA ACGTGCCTTG CGCGAAACGG GTTTTCAGGC351 TGGCAAGTGT CTGCATGCGG GCAACATTAA TCAAATCATG TCCTTAGCAC 401AAAATGCTTT GATCGGCAGG GGATATACCA CGACCCGTAT CTTGGCTGCG 451 CCACAGGATTTGAATAgTGG aAGCTTCAAT TAAThis corresponds to the amino acid sequence <SEQ ID 2852; ORF 930>:

m930.pep 1 MKLPLSYLPN IRFLSWCCLL AGIIAPATLL ASPNPAEIRM QQDIQQRQRE 51EQLRQTMQPE SDVRLHQKNT GETVNQLMGD DSSQPCFAIN EWVLEGEHHA 101 RFQFALKRALRETGFQAGKC LHAGNINQIM SLAQNALIGR GYTTTRILAA 151 PQDLNSGSFN *The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2853>:

g930-1.seq (partial) 1 GGCAAGTGTC TGCATGCGGG CGACATTAAT CAAATCATGTCCTTAGCACA 51 AAATGCTTTG ATCGGCAGGG GATATACCAC GACCCGTATC TTGGCTGCGC 101CACAGGATTT GAATAGTGGC AAGCTTCAAT TAACCCTGAT GCCGGGCTAT 151 CTGCGCTCCATACGAATCGA TCGGTCCAAC GATGATCAAA CCCATGCAGG 201 ACGTATTGCA GCATTCCAAAACAAATTTCC CACCCGCTCG AACGATCTGT 251 TGAATCTGCG TGATTTGGAA CAAGGACTGGAAAATCTCAA ATGTCTCCCG 301 ACTGCGGAAG CCGATCTCCA AATCGTTCCC GTAGAGAGAGAACCAAACCA 351 AAGTGATGTC GTGGTGCAAT GGCGGTAACG TCTGCTGCCC TACTGTGTGA401 GTGTGGGGAT GGATAATTCG GGTAGTGAGG CGACAGGAAA ATACCAAGGA 451AATATCACTT TCTCTGCCGA CAATCCTTTT GGACTGAGTG ATATGTTCTA 501 TGTAAATTATGGACGTTCAA TTGGCGGTAC GCCCGATGAG GAAAATTTTG 551 ACGGCCATCG CAAAGAAGGCGGATCAAACA ATTACGCCGT ACATTATTCA 601 GCCCCTTTCG GTAAATGGAC ATGGGCATTCAATCACAATG GCTACCGTTA 651 CCATCAGGCG GTTTCCGGAT TATCGGAAGT CTATGACTATAATGGAAAAA 701 GTTACAACAC TGATTTCGGC TTCAACCGCC TGTTGTATCG TGATGCCAAA751 CGCAAAACCT ATCTCAGTGT AAAACTGTGG ACGAGGGAAA CAAAAAGTTA 801CATTGATGAT GCCGAACTGA CTGTACAACG GCGTAAAACC ACAGGTTGGT 851 TGGCAGAACTTTCCCACAAA GGATATATCG GTCGCAGTAC GGCAGATTTT 901 AAGTTGAAAT ATAAACACGGCACCGGCATG AAAGATGCTC TGCGCGCGCC 951 TGAAGAAGCC TTTGGCGAAG GCACGTCACGTATGAAAATT TGGACGGCAT 1001 CGGCTGATGT AAATACTCCT TTTCAAATCG GTAAACAGCTATTTGCCTAT 1051 GACACATCCG TTCATGCACA ATGGAACAAA ACCCCGCTAA CATCGCAAGA1101 CAAACTGGCT ATCGGCGGAC ACCACACCGT ACGTGGCTTC GACGGTGAAA 1151TGAGTTTGCC TGCCGAGCGG GGATGGTATT GGCGCAACGA TTTGAGCTGG 1201 CAATTTAAACCAGGCCATCA GCTTTATCTT GGGGCTGATG TAGGACATGT 1251 TTCAGGACAA TCCGCCAAATGGTTATCGGG CCAAACTCTA GCCGGCACAG 1301 CAATTGGGAT ACGCGGGCAG ATAAAGCTTGGCGGCAACCT GCATTACGAT 1351 ATATTTACCG GCCGTGCATT GAAAAAGCCC GAATATTTTCAGACGAAGAA 1401 ATGGGTAACG GGGTTTCAGG TGGGTTATTC GTTTTGAThis corresponds to the amino acid sequence <SEQ ID 2854; ORF 930-1.ng>:

g930-1.pep (partial) 1 GKCLHAGDIN QIMSLAQNAL IGRGYTTTRI LAAPQDLNSGKLQLTLMPGY 51 LRSIRIDRSN DDQTHAGRIA AFQNKFPTRS NDLLNLRDLE QGLENLKCLP 101TAEADLQIVP VEREPNQSDV VVQWR*RLLP YCVSVGMDNS GSEATGKYQG 151 NITFSADNPFGLSDMFYVNY GRSIGGTPDE ENFDGHRKEG GSNNYAVHYS 201 APFGKWTWAF NHNGYRYHQAVSGLSEVYDY NGKSYNTDFG FNRLLYRDAK 251 RKTYLSVKLW TRETKSYIDD AELTVQRRKTTGWLAELSHK GYIGRSTADF 301 KLKYKHGTGM KDALRAPEEA FGEGTSRMKI WTASADVNTPFQIGKQLFAY 351 DTSVHAQWNK TPLTSQDKLA IGGHHTVRGF DGEMSLPAER GWYWRNDLSW401 QFKPGHQLYL GADVGHVSGQ SAKWLSGQTL AGTAIGIRGQ IKLGGNLHYD 451IFTGRALKKP EYFQTKKWVT GFQVGYSF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2855>:

m930-1.seq 1 ATGAAACTTC CTTTATCCTA TTTGCCTAAT ATTCGCTTTT TGTCTTGGTG 51CTGCTTATTG GCAGGTATCA TTGCTCCTGC TACTTTGTTG GCCTCCCCCA 101 ACCCTGCCGAAATCCGTATG CAGCAAGATA TTCAGCAACG CCAACGCGAA 151 GAGCAGTTGC GCCAAACCATGCAGCCTGAA AGCGATGTGC GTTTGCATCA 201 AAAAAACACG GGGGAAACGG TTAATCAGTTGATGGGCGAT GACAGCAGCC 251 AACCGTGTTT TGCCATTAAC GAAGTGGTGT TGGAAGGCGAACACCATGCT 301 CGGTTTCAGT TTGCCCTAAA ACGTGCCTTG CGCGAAACGG GTTTTCAGGC351 TGGCAAGTGT CTGCATGCGG GCAACATTAA TCAAATCATG TCCTTAGCAC 401AAAATGCTTT GATCGGCAGG GGATATACCA CGACCCGTAT CTTGGCTGCG 451 CCACAGGATTTGAATAGTGG CAAGCTTCAA TTAACCCTGA TACCGAGCTA 501 TCTGCGCTCC ATACGAATCGATCGGTCTAA CGATGATCAA ACCCATGCAG 551 GACGTATTGC AGCATTCCAG AACAAATTTCCCACCCGCTC GAACGATCTG 601 TTGAATCTGC GTGATTTGGA ACAAGGACTG GAAAATCTCAAACGTCTCCC 651 GACTGCGGAA GCCGATCTCC AAATCGTTCC CGTAGAGGGA GAACCAAACC701 AAAGTGATGT CGTGGTGCAA TGGCGGCAAC GTCTGCTGCC CTACCGTGTG 751AGTGTGGGGA TGGATAATTC GGGTAGTGAG GCGACAGGAA AATACCAAGG 801 AAATATCACTTTCTCTGCCG ACAATCCTTT GGGACTGAGT GATATGTTCT 851 ATGTAAATTA TGGACGTTCGATTGGCGGTA CGCCCGATGA GGAAAGTTTT 901 GACGGCCATC GCAAAGAAGG CGGATCAAACAATTACGCCG TACATTATTC 951 AGCCCCTTTC GGTAAATGGA CATGGGCATT CAATCACAATGGCTACCGTT 1001 ACCATCAGGC AGTTTCCGGA TTATCGGAAG TCTATGACTA TAATGGAAAA1051 AGTTACAATA CTGATTTCGG CTTCAACCGC CTGTTGTATC GTGATGCCAA 1101ACGCAAAACC TATCTCGGTG TAAAACTGTG GATGAGGGAA ACAAAAAGTT 1151 ACATTGATGATGCCGAACTG ACTGTACAAC GGCGTAAAAC TGCGGGTTGG 1201 TTGGCAGAAC TTTCCCACAAAGAATATATC GGTCGCAGTA CGGCAGATTT 1251 TAAGTTGAAA TATAAACGCG GCACCGGCATGAAAGATGCT CTGCGCGCGC 1301 CTGAAGAAGC CTTTGGCGAA GGCACGTCAC GTATGAAAATTTGGACGGCA 1351 TCGGCTGATG TAAATACTCC TTTTCAAATC GGTAAACAGC TATTTGCCTA1401 TGACACATCC GTTCATGCAC AATGGAACAA AACCCCGCTA ACATCGCAAG 1451ACAAACTGGC TATCGGCGGA CACCACACCG TACGTGGCTT CGACGGTGAA 1501 ATGAGTTTGTCTGCCGAGCG GGGATGGTAT TGGCGCAACG ATTTGAGCTG 1551 GCAATTTAAA CCAGGCCATCAGCTTTATCT TGGGGCTGAT GTAGGACATG 1601 TTTCAGGACA ATCCGCCAAA TGGTTATCGGGCCAAACTCT AGTCGGCACA 1651 GCAATTGGGA TACGCGGGCA GATAAAGCTT GGCGGCAACCTGCATTACGA 1701 TATATTTACC GGCCGCGCAT TGAAAAAGCC CGAATTTTTC CAATCAAGGA1751 AATGGGCAAG CGGTTTTCAG GTAGGCTATA CGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 2856; ORF 930-1>:

m930-1.pep 1 MKLPLSYLPN IRFLSWCCLL AGIIAPATLL ASPNPAEIRM QQDIQQRQRE 51EQLRQTMQPE SDVRLHQKNT GETVNQLMGD DSSQPCFAIN EVVLEGEHHA 101 RFQFALKRALRETGFQAGKC LHAGNINQIM SLAQNALIGR GYTTTRILAA 151 PQDLNSGKLQ LTLIPSYLRSIRIDRSNDDQ THAGRIAAFQ NKFPTRSNDL 201 LNLRDLEQGL ENLKRLPTAE ADLQIVPVEGEPNQSDVVVQ WRQRLLPYRV 251 SVGMDNSGSE ATGKYQGNIT FSADNPLGLS DMFYVNYGRSIGGTPDEESF 301 DGHRKEGGSN NYAVHYSAPF GKWTWAFNHN GYRYHQAVSG LSEVYDYNGK351 SYNTDFGFNR LLYRDAKRKT YLGVKLWMRE TKSYIDDAEL TVQRRKTAGW 401LAELSHKEYI GRSTADFKLK YKRGTGMKDA LRAPEEAFGE GTSRMKIWTA 451 SADVNTPFQIGKQLFAYDTS VHAQWNKTPL TSQDKLAIGG HHTVRGFDGE 501 MSLSAERGWY WRNDLSWQFKPGHQLYLGAD VGHVSGQSAK WLSGQTLVGT 551 AIGIRGQIKL GGNLHYDIFT GRALKKPEFFQSRKWASGFQ VGYTF* m930-1/g930-1 95.4% identity in 478 aa overlap 90       100       110       120       130       140 m930-1.pepAINEVVLEGEHHARFQFALKRALRETGFQAGKCLHAGNINQIMSLAQNALIGRGYTTTRI                              |||||||:|||||||||||||||||||||| g930-1.pep                              GKCLHAGDINQIMSLAQNALIGRGYTTTRI                                      10        20        30150       160       170       180       190       200 m930-1.pepLAAPQDLNSGKLQLTLIPSYLRSIRIDRSNDDQTHAGRIAAFQNKFPTRSNDLLNLRDLE||||||||||||||||:|:||||||||||||||||||||||||||||||||||||||||| g930-1.pepLAAPQDLNSGKLQLTLMPGYLRSIRIDRSNDDQTHAGRIAAFQNKFPTRSNDLLNLRDLE        40        50        60        70        80        90210       220       230       240       250       260 m930-1.pepQGLENLKRLPTAEADLQIVPVEGEPNQSDVVVQWRQRLLPYRVSVGMDNSGSEATGKYQG||||||| |||||||||||||| |||||||||||| ||||| |||||||||||||||||| g930-1.pepQGLENLKCLPTAEADLQIVPVEREPNQSDVVVQWRXRLLPYCVSVGMDNSGSEATGKYQG       100       110       120       130       140       150270       280       290       300       310       320 m930-1.pepNITFSADNPLGLSDMFYVNYGRSIGGTPDEESFDGHRKEGGSNNYAVHYSAPFGKWTWAF|||||||||:|||||||||||||||||||||:|||||||||||||||||||||||||||| g930-1.pepNITFSADNPFGLSDMFYVNYGRSIGGTPDEENFDGHRKEGGSNNYAVHYSAPFGKWTWAF       160       170       180       190       200       210330       340       350       360       370       380 m930-1.pepNHNGYRYHQAVSGLSEVYDYNGKSYNTDFGFNRLLYRDAKRKTYLGVKLWMRETKSYIDD|||||||||||||||||||||||||||||||||||||||||||||:|||| ||||||||| g930-1.pepNHNGYRYHQAVSGLSEVYDYNGKSYNTDFGFNRLLYRDAKRKTYLSVKLWTRETKSYIDD       220       230       240       250       260       270390       400       410       420       430       440 m930-1.pepAELTVQRRKTAGWLAELSHKEYIGRSTADFKLKYKRGTGMKDALRAPEEAFGEGTSRMKI||||||||||:||||||||| ||||||||||||||:|||||||||||||||||||||||| g930-1.pepAELTVQRRKTTGWLAELSHKGYIGRSTADFKLKYKHGTGMKDALRAPEEAFGEGTSRMKI       280       290       300       310       320       330450       460       470       480       490       500 m930-1.pepWTASADVNTPFQIGKQLFAYDTSVHAQWNKTPLTSQDKLAIGGHHTVRGFDGEMSLSAER|||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||| g930-1.pepWTASADVNTPFQIGKQLFAYDTSVHAQWNKTPLTSQDKLAIGGHHTVRGFDGEMSLPAER       340       350       360       370       380       390510       520       530       540       550       560 m930-1.pepGWYWRNDLSWQFKPGHQLYLGADVGHVSGQSAKWLSGQTLVGTAIGIRGQIKLGGNLHYD||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||| g930-1.pepGWYWRNDLSWQFKPGHQLYLGADVGHVSGQSAKWLSGQTLAGTAIGIRGQIKLGGNLHYD       400       410       420       430       440       450570       580       590 m930-1.pep IFTGRALKKPEFFQSRKWASGFQVGYTF|||||||||||:||::||::||||||:| g930-1.pep IFTGRALKKPEYFQTKKWVTGFQVGYSFX       460       470

a930-1.seq not yet found

a930-1.pep not yet found

The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 2857>:

g931.seq 1 ATGAAACCCA AATTCAAAAC CGTTTTAACC GCGCTGCTTT TGGCGGTTTC 51CCTGCCGTCT ATGGCGGCAA CCCGCGTCCT GATGGAAACC GATATGGGCA 101 ATATCCGTTTGGTTTTGGAC GAATCCAAAG CCTCCAAAAC CGTTGCCAAT 151 TTCGTGCGCT ATGCCCGAAAAGGCTTTTAC GACAACACGA TTTTCCACCG 201 CGTcatCGGC GGCTTCGTCA TCCAAGGCGACGGATTGACC GAGGACTTGG 251 TGCAAAAGGC AACCGATAAG GCCGTTGCCA ACGAATCCGGcaacgGCTTG 301 AAAAACACCG TCGGCACCAT CGCAATGGCG CGGACGGCAG CCCCCGATTC351 CGCCGCCGCC CAATTCTTTA TCAATCTGGC GGACAACGGT TCGCTCGACT 401ACAAAAACGG ACAATACGGC TACACCGTTT TCGGCAGGGT AGAAAGCGGA 451 ATGGACACCGTTTCCAAAAT CGCCCGCGTC AAAACCGCCA CGCGCGGCTT 501 TTATCAAAAC GTACCCGTACAGCCCGTCAA AATCCGTCGC GTTGTTGTCG 551 GGCAGTAACA CGCAGACAGA CGTTCAGACGGCGTCGCCCG TTTCCCAAAA 601 AACGCCGTTT AAThis corresponds to the amino acid sequence <SEQ ID 2858; ORF 931.ng>:

g931.pep 1 MKPKFKTVLT ALLLAVSLPS MAATRVLMET DMGNIRLVLD ESKASKTVAN 51FVRYARKGFY DNTIFHRVIG GFVIQGDGLT EDLVQKATDK AVANESGNGL 101KNTVGTIAMA RTAAPDSAAA QFFINLADNG SLDYKNGQYG YTVFGRVESG 151MDTVSKIARV KTATRGFYQN VPVQPVKIRR VVVGQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2859>:

m931.seq 1 ATGAAACCCA AATTCAAAAC CGTTTTAACC GCGCTGCTTT TGGCGGTTTC 51CCTGCCGTCT ATGGCGGCAA CCCATGTTTT GATGGAAACC GATATGGGCA 101ATATCCGTTT GGTTTTGGAC GAATCCAAAG CCCCCAAAAC CGTTGCTAAT 151TTCGTGCGCT ATGCCCGAAA AGGCTTTTAC GACGACACCG TTTTTCACCG 201CGTTATCGAC GGTTTTGTTA TCCAGGGCGG TGGATTGACC GAGGACTTGG 251CACAAAAGGC AAGCGATAAG GCCGTTGCCA ACGAATCCGG CAACGGCTTG 301AAAAACACCG CCGGCACCAT CGCCATGGCG CGGACGACAG CCCCCGATTC 351CGCCACCAGC CAATTCTTTA TCAATCTGGC GGACcA.kCT TCGCTCGACT 401ACAAAAACGG ACAATACGGC TATACCGTTT TCGGCAGGGT CGAAAGCGGC 451ATGAACACCG TTTCCAAAAT CGCCCGCGTC AAAACCGCCA CGCGCGGCTT 501TTATCAAAAC GTACCCGTAC AGCCCGTCAA AATCCGTCGC GTTGTTGTCG 551 GGCAGTAAThis corresponds to the amino acid sequence <SEQ ID 2860; ORF 931>:

m931.pep.. 1 MKPKFKTVLT ALLLAVSLPS MAATHVLMET DMGNIRLVLD ESKAPKTVAN 51FVRYARKGFY DDTVFHRVID GFVIQGGGLT EDLAQKASDK AVANESGNGL 101KNTAGTIAMA RTTAPDSATS QFFINLADXX SLDYKNGQYG YTVFGRVESG 151MNTVSKIARV KTATRGFYQN VPVQPVKIRR VVVGQ*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 931 shows 91.9% identity over a 185 aa overlap with a predicted ORF(ORF 931.ng) from N. gonorrhoeae:

g931/m931         10        20        30        40        50        60g931.pep MKPKFKTVLTALLLAVSLPSMAATRVLMETDMGNIRLVLDESKASKTVANFVRYARKGFY||||||||||||||||||||||||:||||||||||||||||||| ||||||||||||||| m931MKPKFKTVLTALLLAVSLPSMAATHVLMETDMGNIRLVLDESKAPKTVANFVRYARKGFY        10        20        30        40        50        60        70        80        90       100       110       120 g931.pepDNTIFHRVIGGFVIQGDGLTEDLVQKATDKAVANESGNGLKNTVGTIAMARTAAPDSAAA |:|:||||||||||| ||||||:|||:|||||||||||||||:||||||||:|||||:: m931DDTVFHRVIDGFVIQGGGLTEDLAQKASDKAVANESGNGLKNTAGTIAMARTTAPDSATS        70        80        90       100       110       120       130       140       150       160       170       180 g931.pepQFFINLADNGSLDYKNGQYGYTVFGRVESGMDTVSKIARVKTATRGFYQNVPVQPVKIRR |||||||| |||||||||||||||||||||:|||||||||||||||||||||||||||| m931QFFINLADXXSLDYKNGQYGYTVFGRVESGMNTVSKIARVKTATRGFYQNVPVQPVKIRR       130       140       150       160       170       180 g931.pepVVVGQX |||||| m931 VVVGQXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2861>:

a931.seq 1 ATGAAACCCA AATTCAAAAC CGTTTTAACC GCGCTGCTTT TGGCGGTTTC 51CCTGCCGTCT ATGGCGGCAA CCCATGTTTT GATGGAAACC GATATGGGCA 101ATATCCGTTT GGTTTTGGAC GAATCCAAAG CACCCAAAAC CGTTGCCAAT 151TTCGTGCGCT ATGCCCGAAA AGGCTTTTAC GACAATACGA TTTTTCACCG 201CGTCATCGGC GGCTTCGTTA TCCAAGGCGG CGGATTGACC GAGGACTTGG 251CACAAAAGGC AAGCGATAAG GCCGTTGCCA ACGAATCCGG CAACGGCTTG 301AAAAACACTG TCGGCACCAT CGCCATGGCG CGGACGGCCG ATCCGGATTC 351CGCCACCAGC CAATTCTTTA TCAATCTGGT GGACAATGAT TCGCTCAACT 401ACAAAAACGG ACAATACGGC TATACCGTTT TCGGCAGGGT CGAAAGCGGC 451ATGAACACCG TTTCCAAAAT CGCCCGCGTC AAAACCGCCA CGCGCGGCTT 501TTATCAAAAC GTACCCGTAC AGCCCGTCAA AATCCGTCGC GTTGTTGTCG 551 GGCAGTAAThis corresponds to the amino acid sequence <SEQ ID 2862; ORF 931.a>:

a931.pep 1 MKPKFKTVLT ALLLAVSLPS MAATHVLMET DMGNIRLVLD ESKAPKTVAN 51FVRYARKGFY DNTIFHRVIG GFVIQGGGLT EDLAQKASDK AVANESGNGL 101KNTVGTIAMA RTADPDSATS QFFINLVDND SLNYKNGQYG YTVFGRVESG 151MNTVSKIARV KTATRGFYQN VPVQPVKIRR VVVGQ* m931/a93194.6% identity in 185 aa overlap        10        20        30        40        50        60 m931.pepMKPKFKTVLTALLLAVSLPSMAATHVLMETDMGNIRLVLDESKAPKTVANFVRYARKGFY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a931MKPKFKTVLTALLLAVSLPSMAATHVLMETDMGNIRLVLDESKAPKTVANFVRYARKGFY        10        20        30        40        50        60        70        80        90       100       110       120 m931.pepDDTVFHRVIDGFVIQGGGLTEDLAQKASDKAVANESGNGLKNTAGTIAMARTTAPDSATS |:|:||||||||||||||||||||||||||||||||||||||:||||||||: |||||| a931DNTIFHRVIGGFVIQGGGLTEDLAQKASDKAVANESGNGLKNTVGTIAMATADPDSATS        70        80        90       100       110       120       130       140       150       160       170       180 m931.pepQFFINLADXXSLDYKNGQYGYTVFGRVESGMNTVSKIARVKTATRGFYQNVPVQPVKIRR ||||||:| ||:||||||||||||||||||||||||||||||||||||||||||||||| a931QFFINLVDNDSLNYKNGQYGYTVFGRVESGMNTVSKIARVKTATRGFYQNVPVQPVKIRR       130       140       150       160       170       180 m931.pepVVVGQX |||||| a931 VVVGQX

g932. seq not found yet

g932. pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2863>:

m932.seq 1 ATGAAATATA TCGTATCAAT CTCTCTGGCT ATGGGATTGG CTGCCTGTTC 51GTTTGGGGGA TTTAAACCAA ATCCGTGGGA CGCCGCGTCA TTTTGGGAAT 101TGAAAAATTA CGCCAATCCC TATCCGGGAT CAGCCTCGGC GGCACTTGAC 151CAATATCCAT CGAAAGCAAG ACGAAGGCAA CTGAAAGACA TGCAAGAGTG 201CGGCTATGAC CCAATAGACG GCGGAAAGTC TGAAGCAGAT GCCTGCCTGA 251GGAAAAAAGG CTGGTGTCGT AAGGGTTTCG ACCCTTATCC CGAAAACAAA 301AAATACGAAT GGCCTCGAGA AGAAGGAAAA ACAAAATGAThis corresponds to the amino acid sequence <SEQ ID 2864; ORF 932>:

m932.pep 1 MKYIVSISLA MGLAACSFGG FKPNPWDAAS FWELKNYANP YPGSASAALD 51QYPSKARRRQ LKDMQECGYD PIDGGKSEAD ACLRKKGWCR KGFDPYPENK 101KYEWPREEGK TK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 932 shows ______ % identity over a ______ aa overlap with apredicted ORF (ORF 932.ng) from N. gonorrhoeae:The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 2865>:

g934.seq 1 ATGAAAAAAA TCATCGCCTC CGCGCTTATC GCAACATTCG CACTCACCGC 51CTGCCAAGAC GACACGCAGG CGCGGCTCGA ACGGCAGCAG AAACAGATTG 101AAGCCCTGCA ACAGCAGCTC GCACAGCAGG CAGACGATAC GGTTTACCAA 151CTGACTCCCG AAGCAGTCAA AGACACCATT CCTGCCCAGG CGCAGGCAAA 201CGGCAACAAC GGTCAGCCCG TTACCGGCAA .AGAcggGCA GCAGTATATT 251TACGACCAAT CGACAGGAAG CTGGCTGCTG CAAAGCCTGA TTGGCGCGGC 301GGCAGGCGCG TTTATCGGCA ACGCGCTGGC AAACAAATTC ACACGGGCGG 351GCAACCAAGA CAGCCCCGTC GCCCGTCGCG CGCGTGCTGC CTACCATCAG 401TCCGCACGCC CCAATGCGCG CACCAGCAGG GATTTGAACA CGCGCAGCCT 451CCGTGCAAAA CAACAGGCGG CGCAGGCGCA GCGTTACCGC CCGACAACGC 501GCCCGCCCGT CAAttaccgc catcgcgcta tgcGCGGTTT CGgcagAagg 551cggtaaaCCC GGCGCGTCAA TGCCGTCTGA AGGGCTTTCA GACGGCATTT 601TTGTATTTGT TAGGGGCATT GTTATGTTGC CGTTTGATTT TCAGACGGCA 651TTTTGTTTCC AAGCGTTTGA TGTcggGATG GCAATTCTGAThis corresponds to the amino acid sequence <SEQ ID 2866; ORF 934.ng>:

g934.pep 1 MKKIIASALI ATFALTACQD DTQARLERQQ KQIEALQQQL AQQADDTVYQ 51LTPEAVKDTI PAQAQANGNN GQPVTGKRRA AVYLRPIDRK LAAAKPDWRG 101GRRVYRQRAG KQIHTGGQPR QPRRPSRACC LPSVRTPQCA HQQGFEHAQP 151PCKTTGGAGA ALPPDNAPAR QLPPSRYARF RQKAVNPARQ CRLKGFQTAF 201LYLLGALLCC RLIFRRHFVS KRLMSGWQF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2867>:

m934.seq (partial) 1..CGGCTCGAAC AGCAGCAGAA ACAGATTGAA GCCCTGCAAC AGCAGCTCGC 51  ACAGCAGGCA GACGATACGG TTTACCAACT GACTCCCGAA GCAGTCAAAG 101  ACACCATTCC TGCCGAAGCA CAGGCAAACG GCAACAACgG GCAACCCGTT 151  ACCGGTAA.A GACGGGCAGC AGTATATTTA CGACCAATCG ACAGGAAGCT 201  GGCTGCTGCA AAGCCTGGTC GGCGCGGCGG CAGGCGCGTT TATCGGCAAC 251  GCGCTGGCAA ACAAATTCAC ACGGGCAGGC AACCAAGACA GTCCCGTCGC 301  CCGGCGCGCG CGTGCAGCCT ACCATCAGTC CGCACGCCCC AATGCGCGCA 351  yCAGCAGGGA TTTGAACACG CGCAGCCTCC GTGCAAAACA ACAGGCGGCG 401  CAkGCGCAGC GTTACCGCCC GACAACGCGC CCGsCCGsCA ATTACCGCCG 451  CCCCGCTATG CGCGGTTTCG GCAGGAGGCG GTAAACCCGG CGCGCCAATG 501  CCGTCTGAAG AGCTTTCAGA CGGCATTTnT GCATTTGTTA GGGACATTGT 551  TATGTTGCCG TTTGATTTTC AGACGGCATT TTGTTTCCAA GCGTTTGATG 601  TCGGGATGGC AATTCTGAThis corresponds to the amino acid sequence <SEQ ID 2868; ORF 934>:

m934.pep (partial) 1..RLEQQQKQIE ALQQQLAQQA DDTVYQLTPE AVKDTIPAEA QANGNNGQPV 51  TGXRRAAVYL RPIDRKLAAA KPGRRGGRRV YRQRAGKQIH TGRQPRQSRR 101  PARACSLPSV RTPQCAHQQG FEHAQPPCKT TGGAXAALPP DNAPXRQLPP 151  PRYARFRQEA VNPARQCRLK SFQTAFXHLL GTLLCCRLIF RRHFVSKRLM 201   SGWQF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 934 shows 91.7% identity over a 205 aa overlap with a predicted ORF(ORF 934.ng) from N. gonorrhoeae:

m934/g934                                 10        20        30m934.pep                         RLEQQQKQIEALQQQLAQQADDTVYQLTPEAVKDTI                        |||:|||||||||||||||||||||||||||||||| g934MKKIIASALIATFALTACQDDTQARLERQQKQIEALQQQLAQQADDTVYQLTPEAVKDTI        10        20        30        40        50        60  40        50        60        70        80        90 m934.pepPAEAQANGNNGQPVTGXRRAAVYLRPIDRKLAAAKPGRRGGRRVYRQRAGKQIHTGRQPR||:||||||||||||| |||||||||||||||||||  |||||||||||||||||| ||| g934PAQAQANGNNGQPVTGKRRAAVYLRPIDRKLAAAKPDWRGGRRVYRQRAGKQIHTGGQPR        70        80        90       100       110       120 100       110       120       130       140       150 m934.pepQSRRPARACSLPSVRTPQCAHQQGFEHAQPPCKTTGGAXAALPPDNAPXRQLPPPRYARF | |||:||||||||||||||||||||||||||||||| ||||||||| ||||| ||||| g934QPRRPSRACCLPSVRTPQCAHQQGFEHAQPPCKTTGGAGAALPPDNAPARQLPPSRYARF       130       140       150       160       170       180 160       170       180       190       200 m934.pepRQEAVNPARQCRLKSFQTAFXHLLGTLLCCRLIFRRHFVSKRLMSGWQFX ||:|||||||||||:|||||:|||:|||||||||||||||||||||||| g934RQKAVNPARQCRLKGFQTAFLYLLGALLCCRLIFRRHFVSKRLMSGWQFX       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2869>:

a934.seq 1 ATGAAAAAAA TCATCGCCTC CGCGCTTATC GCAACATTCG CACTCGCCGC 51CTGCCAAGAC GACGCGCAGG CGCGGCTCGA ACAGCAGCAG AAACAGATTG 101AAGCCCTGCA ACAGCAGCTC GCACAGCAGG CAGACGATAC GGTTTACCAA 151CTGACTCCCG AAGCAGTCAA AGACACCATT CCTGCCGAAG CACAGGCAAA 201CGGCAACAAC GGGCAACCCG TTACCGG.TA AAGACGGGCA GCAGTATATT 251TACGACCAAT CGACAGGAAG CTGGCTGCTG CAAAGCCTGG TCGGCGCGGC 301GGCAGGCGCG TTTATCGGCA ACGCGCTGGC AAACAAATTC ACACGGGCAG 351GCAACCAAGA CAGTCCCGTC GGCAGGCGCG CGCGTGCCGC CTACCATCAG 401TCCGCACATC CCAATGCGCG CACCAGCAGG GATTTGAACA CGCGCAGCCT 451CCGTGCAAAA CAACAGGCGG CGCAGGCGCA GCGTTACCGC CCGACAACGC 501GCCCGCCCGC CAATTACCGC CGCCCCGCCA TGCGCGGTTT CGGCAGAAGG 551CGGTAAATCC GGCGTGCCAA TGCCGTCTGA AGGGCTTTCA GACGGCATTT 601TTGTATTTGT TAGGGACATT GTTATGTTGC CGTTTGATTT TTAGACGGCA 651TTTTGTTTCC AAGAGTTTGA TGTCGGGATG GCAATTCTGAThis corresponds to the amino acid sequence <SEQ ID 2870; ORF 934.a>:

a934.pep 1 MKKIIASALI ATFALAACQD DAQARLEQQQ KQIEALQQQL AQQADDTVYQ 51LTPEAVKDTI PAEAQANGNN GQPVTX*RRA AVYLRPIDRK LAAAKPGRRG 101GRRVYRQRAG KQIHTGRQPR QSRRPARACR LPSVRTSQCA HQQGFEHAQP 151PCKTTGGAGA ALPPDNAPAR QLPPPRHARF RQKAVNPACQ CRLKGFQTAF 201LYLLGTLLCC RLIFRRHFVS KSLMSGWQF* m934/a93494.1% identity in 205 aa overlap                                10        20        30 m934.pep                        RLEQQQKQIEALQQQLAQQADDTVYQLTPEAVKDTI                        |||||||||||||||||||||||||||||||||||| a934MKKIIASALIATFALAACQDDAQARLEQQQKQIEALQQQLAQQADDTVYQLTPEAVKDTI        10        20        30        40        50        60  40        50        60        70        80        90 m934.pepPAEAQANGNNGQPVTGXRRAAVYLRPIDRKLAAAKPGRRGGRRVYRQRAGKQIHTGRQPR||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| a934PAEAQANGNNGQPVTXXRRAAVYLRPIDRKLAAAKPGRRGGRRVYRQRAGKQIHTGRQPR        70        80        90       100       110       120 100       110       120       130       140       150 m934.pepQSRRPARACSLPSVRTPQCAHQQGFEHAQPPCKTTGGAXAALPPDNAPXRQLPPPRYARF ||||||||||||||| ||||||||||||||||||||| ||||||||| |||||||:||| a934QSRRPARACRLPSVRTSQCAHQQGFEHAQPPCKTTGGAGAALPPDNAPARQLPPPRHARF       130       140       150       160       170       180 160       170       180       190       200 m934.pepRQEAVNPARQCRLKSFQTAFXHLLGTLLCCRLIFRRHFVSKRLMSGWQFX ||:||||| |||||:|||||:||||||||||||||||||| |||||||| a934RQKAVNPACQCRLKGFQTAFLYLLGTLLCCRLIFRRHFVSKSLMSGWQFX       190       200       210       220       230

g935.seq not found yet

g935.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2871>:

m935.seq 1 ATGTTGTATT TCAGATACGG CTTTTTGGTT GTTTGGTGTG CGGCAGGTGT 51TTCTGCCGCC TATGGGGCGG ATGCGCCCGC GATTTTGGAT GACAAGGCAT 101 TGTTGCAGGTGCAGCGGTCG GTGTCGGATA AGTGGGCGGA ATCAGATTGG 151 AAAGTTGAAA ATGATGCCCCGCGCGTGGTT GACGGGGATT TTTTGTTGGC 201 GCATCCGAAA ATGTTGGAAC ATAGTTTGCGCGACGCGCTC AACGGCAATC 251 AGGCGGATTT AATCGCTTCG TTGGCGGATT TGTATGCCAAGCTGCCGGAT 301 TATGACGCGG TTTTGTACGG CAGGGCGCGG GCTTTGCTGG CGAAATTGGC351 GGGAAGGCCG GCGGAGGCGG TGGCGCGGTA TCGGGAACTG CACGGGGAAA 401ATGCGGCAGA CGAGCGGATT TTGCTGGATT TGGCGGCGGC GGAGTTTGAC 451 GATTTCCGGCTGAAGTCGGC AGAAAGGCAT TTTGCGGAGG CGGCAAAATT 501 GGATTTGCCG GCACCGGTTTTGGAAAATGT GGGGCGTTTT CGGAAAAAAA 551 CGGAGGGGCT GACGGGCTGG CGTTTTTCGGGCGGCATCAG TCCGGCGGTC 601 AATAGAAATG CCAATAATGC CGCGCCGCAA TATTGCCGGCAAAACGGAGG 651 CCGGCAGATA TGCAGTGTCA GCCGGGCGGA GCGGGCGGCA GGGTTGAATT701 ATGAAATCGA GGCGGAAAAG CTGACGCCGT TGGCAGATAA TCATTATTTG 751TTGTTCCGTT CCAATATCGG CGGCACGAGC TATTATTTCA GTAAAAAATC 801 AGCTTATGATGACGGGTTCG GCAGGGCGTA TTTGGGTTGG CAGTATAAAA 851 ATGCACGGCA GACGGCGGGGATTTTGCCGT TTTATCAGGT GCAGTTGTCG 901 GGCAGCGACG GCTTTGATGC GAAAACAAAACGGGTAAACA ACCGCCGCCT 951 GCCGCCGTAT ATGCTGGCGC ACGGAGTCGG CGTGCAGCTGTCCCATACTT 1001 ACCGCCCAAA CCCGGGATGG CAATTTTCGG TCGCGCTGGA ACATTACCGC1051 CAACGCTACC GCGAACAGGA TAGGGCGGAA TACAATAACG GCAGGCAGGA 1101CGGGTTTTAT GTTTCGTCGG CAAAACGTTT GGGCGAATCG GCAACTGTGT 1151 TCGGCGGCTGGCAGTTTGTG CGGTTTGTGC CGAAACGCGA AACGGTGGGC 1201 GGCGCGGTCA ATAATGCCGCCTACCGGCGC AACGGTGTTT ATGCCGGTTG 1251 GGCGCAGGAG TGGCGGCAGT TGGGCGGTTTGAACAGTCGG GTTTCCGCGT 1301 CTTATGCCCG CCGCAACTAT AAGGGCATTG CGGCTTTCTCGACAGAGGCG 1351 CAACGCAACC GCGAATGGAA TGTCTCGCTG GCTTTGAGCC ACGACAAGTT1401 GTCGTACAAA GGTATCGTGC CGGCGTTGAA TTATCGTTTC GGCAGGACGG 1451AAAGTAATGT GCCGTATGCG AAACGCCGCA ACAGCGAGGT GTTTGTGTCG 1501 GCGGATTGGCGGTTTTGAThis corresponds to the amino acid sequence <SEQ ID 2872; ORF 935>:

m935.pep 1 MLYFRYGFLV VWCAAGVSAA YGADAPAILD DKALLQVQRS VSDKWAESDW 51KVENDAPRVV DGDFLLAHPK MLEHSLRDAL NGNQADLIAS LADLYAKLPD 101 YDAVLYGRARALLAKLAGRP AEAVARYREL HGENAADERI LLDLAAAEFD 151 DFRLKSAERH FAEAAKLDLPAPVLENVGRF RKKTEGLTGW RFSGGISPAV 201 NRNANNAAPQ YCRQNGGRQI CSVSRAERAAGLNYEIEAEK LTPLADNHYL 251 LFRSNIGGTS YYFSKKSAYD DGFGRAYLGW QYKNARQTAGILPFYQVQLS 301 GSDGFDAKTK RVNNRRLPPY MLAHGVGVQL SHTYRPNPGW QFSVALEHYR351 QRYREQDRAE YNNGRQDGFY VSSAKRLGES ATVFGGWQFV RFVPKRETVG 401GAVNNAAYRR NGVYAGWAQE WRQLGGLNSR VSASYARRNY KGIAAFSTEA 451 QRNREWNVSLALSHDKLSYK GIVPALNYRF GRTESNVPYA KRRNSEVFVS 501 ADWRF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2873>:

a935.seq 1 ATGTTGTATT TCAGATACGG TTTTTTGGTT GTTTGGTGTG CGGCAGGTGT 51TTCTGCCGCC TATGGGGCGG ATGCGCCCGC GATTTTGGAT GACAAGGCAT 101 TGTTGCAGGTGCAGCGGTCG GTGTCGGATA AGTGGGCGGA ATCGGATTGG 151 AAAGTTGACA ATGATGCCCCGCGCGTGGTT GACGGGGATT TTTTGTTGGC 201 GCATCCGAAA ATGTTGGAAC ATAGTTTGCGCGACGTGCTC AACGGCAATC 251 AGGCGGATTT GATCGCTTCG TTGGCGGATT TGTATGCCAAGCTGCCGGAT 301 TATGACGCGG TTTTGTACGG CAGGGCGCGG GCTTTGCTGG CGAAATTGGC351 GGGAAGGCCG GCGGAGGCGG TGGCGCGGTA TCGGGAACTG CACGGGGAAA 401ATGCGGCAGA CGAGCGGATT TTGCTGGATT TGGCGGCGGC GGAGTTTGAC 451 GATTTCCGGCTGAAGTCGGC AGAAAGGCAT TTTGCCGAGG CGGAAAAATT 501 GGATTTGCCG GCGCCGGTTTTGGAAAATGT GGGGCGTTTT CGGAAAAAAG 551 CGGAGGGGCT GACGGGCTGG CGTTTTTCGGGCGGCATCAG TCCGGCGGTC 601 AATAGAAATG CCAATAATGC CGCGCCGCAG TATTGCCGGCAAAACGGAGG 651 CCGGCAGATA TGCAGTGTCA GCCGGGCGGA GCGGGCGGCA GGCTTGAATT701 ATGAAATCGA GGCGGAAAAA CTGACGGCGT TGGCAGATAA TCATTATTTG 751TTGTTCCGTT CCAATATCGG CGGCACGAGC TATTATTTCA GTAAAAAATC 801 AGCTTATGACGACGGGTTCG GCAGAGCGTA TTTGGGTTGG CAGTATAAAA 851 ATGCACGGCA GACGGCGGGGATTTTGCCGT TTTATCAGGT GCAGTTGTCG 901 GGCAGCGACG GCTTTGATGC GAAAACAAAACGGGTAAACA ACCGCCGCCT 951 GCCGCCGTAT ATGCTGGCGC ACGGAGTCGG CGTGCAGTTGTCCCATACTT 1001 ACCGCCCAAA CCCGGGATGG CAATTTTCGG TCGCGCTGGA ACATTACCGC1051 CAACGCTACC GCGAACAGGA TAGGGCGGAA TACAATAACG GTCGGCAGGA 1101CGGGTTTTAT GTTTCGTCGG CAAAACGTTT GGGCGAATCG GCAACTGTGT 1151 TCGGCGGCTGGCAGTTTGTG CGGTTTGTGC CGAAACGCGA AACGGTGGGC 1201 GGCGCGGTCA ATAATGCCGCCTACCGGCGC AACGGTGTTT ATGCCGGCTG 1251 GGCGCAGGAG TGGCGGCAGT TGGGCGGTTTGAACAGTCGG GTTTCCGCGT 1301 CTTATGCCCG CCGCAACTAT AAGGGCGTTG CGGCTTTCTCGACAGAGGCG 1351 CAACGCAACC GCGAATGGAA TGTCTCGCTG GCTTTGAGCC ACGACAAGTT1401 GTCGTACAAA GGTATCGTGC CCGCGTTGAA TTATCGTTTC GGCAGGACGG 1451AAAGTAATGT GCCGTATGCG AAACGCCGCA ACAGCGAGGT GTTTGTGTCG 1501 GCGGATTGGCGGTTTTGAThis corresponds to the amino acid sequence <SEQ ID 2874; ORF 935.a>:

a935.pep 1 MLYFRYGFLV VWCAAGVSAA YGADAPAILD DKALLQVQRS VSDKWAESDW 51KVDNDAPRVV DGDFLLAHPK MLEHSLRDVL NGNQADLIAS LADLYAKLPD 101 YDAVLYGRARALLAKLAGRP AEAVARYREL HGENAADERI LLDLAAAEFD 151 DFRLKSAERH FAEAEKLDLPAPVLENVGRF RKKAEGLTGW RFSGGISPAV 201 NRNANNAAPQ YCRQNGGRQI CSVSRAERAAGLNYEIEAEK LTALADNHYL 251 LFRSNIGGTS YYFSKKSAYD DGFGRAYLGW QYKNARQTAGILPFYQVQLS 301 GSDGFDAKTK RVNNRRLPPY MLAHGVGVQL SHTYRPNPGW QFSVALEHYR351 QRYREQDRAE YNNGRQDGFY VSSAKRLGES ATVFGGWQFV RFVPKRETVG 401GAVNNAAYRR NGVYAGWAQE WRQLGGLNSR VSASYARRNY KGVAAFSTEA 451 QRNREWNVSLALSHDKLSYK GIVPALNYRF GRTESNVPYA KRRNSEVFVS 501 ADWRF* m935/a935 98.8%identity in 505 aa overlap        10        20        30        40        50        60 m935.pepMLYFRYGFLVVWCAAGVSAAYGADAPAILDDKALLQVQRSVSDKWAESDWKVENDAPRVV||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||| a935MLYFRYGFLVVWCAAGVSAAYGADAPAILDDKALLQVQRSVSDKWAESDWKVDNDAPRVV        10        20        30        40        50        60        70        80        90       100       110       120 m935.pepDGDFLLAHPKMLEHSLRDALNGNQADLIASLADLYAKLPDYDAVLYGRARALLAKLAGRP||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||| a935DGDFLLAHPKMLEHSLRDVLNGNQADLIASLADLYAKLPDYDAVLYGRARALLAKLAGRP        70        80        90       100       110       120       130       140       150       160       170       180 m935.pepAEAVARYRELHGENAADERILLDLAAAEFDDFRLKSAERHFAEAAKLDLPAPVLENVGRF|||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||| a935AEAVARYRELHGENAADERILLDLAAAEFDDFRLKSAERHFAEAEKLDLPAPVLENVGRF       130       140       150       160       170       180       190       200       210       220       230       240 m935.pepRKKTEGLTGWRFSGGISPAVNRNANNAAPQYCRQNGGRQICSVSRAERAAGLNYEIEAEK|||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||| a935RKKAEGLTGWRFSGGISPAVNRNANNAAPQYCRQNGGRQICSVSRAERAAGLNYEIEAEK       190       200       210       220       230       240       250       260       270       280       290       300 m935.pepLTPLADNHYLLFRSNIGGTSYYFSKKSAYDDGFGRAYLGWQYKNARQTAGILPFYQVQLS|| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a935LTALADNHYLLFRSNIGGTSYYFSKKSAYDDGFGRAYLGWQYKNARQTAGILPFYQVQLS       250       260       270       280       290       300       310       320       330       340       350       360 m935.pepGSDGFDAKTKRVNNRRLPPYMLAHGVGVQLSHTYRPNPGWQFSVALEHYRQRYREQDRAE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a935GSDGFDAKTKRVNNRRLPPYMLAHGVGVQLSHTYRPNPGWQFSVALEHYRQRYREQDRAE       310       320       330       340       350       360       370       380       390       400       410       420 m935.pepYNNGRQDGFYVSSAKRLGESATVFGGWQFVRFVPKRETVGGAVNNAAYRRNGVYAGWAQE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a935YNNGRQDGFYVSSAKRLGESATVFGGWQFVRFVPKRETVGGAVNNAAYRRNGVYAGWAQE       370       380       390       400       410       420       430       440       450       460       470       480 m935.pepWRQLGGLNSRVSASYARRNYKGIAAFSTEAQRNREWNVSLALSHDKLSYKGIVPALNYRF||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||| a935WRQLGGLNSRVSASYARRNYKGVAAFSTEAQRNREWNVSLALSHDKLSYKGIVPALNYRF       430       440       450       460       470       480       490       500 m935.pep GRTESNVPYAKRRNSEVFVSADWRFX|||||||||||||||||||||||||| a935 GRTESNVPYAKRRNSEVFVSADWRFX       490       500The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 2875>:

g936.seq 1 ATGAAACCCA AACCACACAC CGTCCGCACC CTGATTGCCG CCGTCCTCAG 51CCTTGCCCTC GGCGGCTGCT TCAGCGCAGT CGTCGGCGGG GCCGCCGTCG 101 GCGCAAAATCCGTCATCGAC CGccgAACCA CCGgcgcgca AACCGATGac 151 aACGTTATGG CGTTGCGTATCGAAACCACC GCCCGTTCCT ACCTGCGCCA 201 AAACAACCAA ACCAAAGGCT ACACGCCCCAAATCTCCGTC GTCGGCTACA 251 ACCGCCACCT GCTGCTGCTC GGACAAGTCG CCACCGAAGGCGAAAAACAG 301 TTCGTCGGTC AGATTGCACG TTCCGAACAG GCCGCCGAAG GCGTATACAA351 CTACATTACC GTCGCCTCCC TGCCGCGCAC TGCGGGCGAC ATCGCCGGCG 401ACACTTGGAA CACGTCCAAA GTCCGCGCca cgCTGCTGGG CATCAGCCCC 451 GCTACACAGGCGCGCGTCAA AATCATTACC TACGGCAATG TAACCTACGT 501 TATGGGCATC CTCACCCCCGAAGAACAGGC GCAGATTACC CAAAAAGTCA 551 GCACCAccgT CGGCGTACAA AAAGTCATTACCCTCTACCA AAACTACGTC 601 CAACGCTGAThis corresponds to the amino acid sequence <SEQ ID 2876; ORF 936.ng>:

g936.pep 1 MKPKPHTVRT LIAAVLSLAL GGCFSAVVGG AAVGAKSVID RRTTGAQTDD 51NVMALRIETT ARSYLRQNNQ TKGYTPQISV VGYNRHLLLL GQVATEGEKQ 101 FVGQIARSEQAAEGVYNYIT VASLPRTAGD IAGDTWNTSK VRATLLGISP 151 ATQARVKIIT YGNVTYVMGILTPEEQAQIT QKVSTTVGVQ KVITLYQNYV 201 QR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2877>:

m936.seq (partial) 1 ATGAAACCCA AACCGCACAC CGTCCGCACC CTGATTGCCGCCATTTTCAG 51 CCTTGCCCTT AGCGGCTGCG TCAGCGCAGT AATCGGAAGC GCCGCCGTCG 101GCGCGAAATC CGCCGTCGAC CGCCGAACCA CCGGCGCGCA AACCGACGAC 151 AACGTTATGGCGTTGCGTAT CGAAACCACC GCCCGTTCCT ATCTGCGCCA 201 AAACAACCAA ACCAAAGGCTACACGCCCCA AATCTCCGTC GTCGGCTACA 251 ACCGCCACCT GCTGCTGCTC GGACAAGTCGCCACCGAAGG CGAAAAACAG 301 TTCGTCGGTC AGATTGCACG TTCCGAACAG GCCGCCGAAGGCGTGTACAA 351 CTATATTACC GTCGCCTCCC TGCCGCGCAC TGCC...This corresponds to the amino acid sequence <SEQ ID 2878; ORF 936>:

m936.pep (partial) 1 MKPKPHTVRT LIAAIFSLAL SGCVSAVIGS AAVGAKSAVDRRTTGAQTDD 51 NVMALRIETT ARSYLRQNNQ TKGYTPQISV VGYNRHLLLL GQVATEGEKQ 101FVGQIARSEQ AAEGVYNYIT VASLPRTA...Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 936 shows 93.8% identity over a 128 aa overlap with a predicted ORF(ORF 936.ng) from N. gonorrhoeae:

m936/g936         10        20        30        40        50        60m936.pep MKPKPHTVRTLIAAIFSLALSGCVSAVIGSAAVGAKSAVDRRTTGAQTDDNVMALRIETT||||||||||||||::||||:|| |||:|:|||||||::||||||||||||||||||||| g936MKPKPHTVRTLIAAVLSLALGGCFSAVVGGAAVGAKSVIDRRTTGAQTDDNVMALRIETT        10        20        30        40        50        60        70        80        90       100       110       120 m936.pepARSYLRQNNQTKGYTPQISVVGYNRHLLLLGQVATEGEKQFVGQIARSEQAAEGVYNYIT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g936ARSYLRQNNQTKGYTPQISVVGYNRHLLLLGQVATEGEKQFVGQIARSEQAAEGVYNYIT        70        80        90       100       110       120        130m936.pep VASLPRTAXXX |||||||| g936VASLPRTAGDIAGDTWNTSKVRATLLGISPATQARVKIITYGNVTYVMGILTPEEQAQIT       130       140       150       160       170       180The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2879>:

a936.seq 1 ATGAAACCCA AACCGCACAC CGTCCGCACC CTGACTGCCG CCGTCCTCAG 51CCTTGCCCTC GGCGGCTGCG TCAGCGCAGT CGTCGGCGGC GCGGCGGTCG 101 GCGCGAAATCCGCCGTCGAC CGCCGAACCA CCGGCGCGCA AACCGACGAC 151 AACGTAATGG CGCTGCGTATCGAAACCACC GCCCGCTCCT ATCTGCGCCA 201 AAACAACCAA ACCAAAGGCT ACACGCCCCAAATCTCCGTT GTCGGCTACA 251 ACCGCCACCT GCTGCTGCTC GGACAAGTCG CCACCGAAGGCGAGAAACAG 301 TTCGTCGGTC AGATTGCACG TTCCGAACAG GCCGCCGAAG GCGTGTACAA351 CTACATTACC GTCGCCTCCC TGCCGCGCAC TGCCGGCGAC ATCGCCGGCG 401ACACTTGGAA CACATCCAAA GTCCGCGCCA CGCTGTTGGG CATCAGCCCC 451 GCCACACAGGCGCGCGTCAA AATCGTTACC TACGGCAACG TAACCTACGT 501 TATGGGCATC CTCACCCCCGAAGAACAGGC GCAGATTACC CAAAAAGTCA 551 GCACCACCGT CGGCGTACAA AAAGTCATCACCCTCTACCA AAACTACGTC 601 CAACGCTGAThis corresponds to the amino acid sequence <SEQ ID 2880; ORF 936.a>:

a936.pep 1 MKPKPHTVRT LTAAVLSLAL GGCVSAVVGG AAVGAKSAVD RRTTGAQTDD 51NVMALRIETT ARSYLRQNNQ TKGYTPQISV VGYNRHLLLL GQVATEGEKQ 101 FVGQIARSEQAAEGVYNYIT VASLPRTAGD IAGDTWNTSK VRATLLGISP 151 ATQARVKIVT YGNVTYVMGILTPEEQAQIT QKVSTTVGVQ KVITLYQNYV 201 QR* m936/a936 95.3% identity in 128aa overlap         10        20        30        40        50        60m936.pep MKPKPHTVRTLIAAIFSLALSGCVSAVIGSAAVGAKSAVDRRTTGAQTDDNVMALRIETT||||||||||| ||::||||:||||||:|:|||||||||||||||||||||||||||||| a936MKPKPHTVRTLTAAVLSLALGGCVSAVVGGAAVGAKSAVDRRTTGAQTDDNVMALRIETT        10        20        30        40        50        60        70        80        90       100       110       120 m936.pepARSYLRQNNQTKGYTPQISVVGYNRHLLLLGQVATEGEKQFVGQIARSEQAAEGVYNYIT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a936ARSYLRQNNQTKGYTPQISVVGYNRHLLLLGQVATEGEKQFVGQIARSEQAAEGVYNYIT        70        80        90       100       110       120 m936.pepVASLPRTA |||||||| a936VASLPRTAGDIAGDTWNTSKVRATLLGISPATQARVKIVTYGNVTYVMGILTPEEQAQIT       130       140       150       160       170       180The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2881>:

g936-1.seq 1 ATGAAACCCA AACCACACAC CGTCCGCACC CTGATTGCCG CCGTCCTCAG 51CCTTGCCCTC GGCGGCTGCT TCAGCGCAGT CGTCGGCGGG GCCGCCGTCG 101 GCGCAAAATCCGTCATCGAC CGccgAACCA CCGgcgcgca AACCGATGac 151 aACGTTATGG CGTTGCGTATCGAAACCACC GCCCGTTCCT ACCTGCGCCA 201 AAACAACCAA ACCAAAGGCT ACACGCCCCAAATCTCCGTC GTCGGCTACA 251 ACCGCCACCT GCTGCTGCTC GGACAAGTCG CCACCGAAGGCGAAAAACAG 301 TTCGTCGGTC AGATTGCACG TTCCGAACAG GCCGCCGAAG GCGTATACAA351 CTACATTACC GTCGCCTCCC TGCCGCGCAC TGCGGGCGAC ATCGCCGGCG 401ACACTTGGAA CACGTCCAAA GTCCGCGCca cgCTGCTGGG CATCAGCCCC 451 GCTACACAGGCGCGCGTCAA AATCATTACC TACGGCAATG TAACCTACGT 501 TATGGGCATC CTCACCCCCGAAGAACAGGC GCAGATTACC CAAAAAGTCA 551 GCACCAccgT CGGCGTACAA AAAGTCATTACCCTCTACCA AAACTACGTC 601 CAACGCTGAThis corresponds to the amino acid sequence <SEQ ID 2882; ORF 936-1.ng>:

g936-1.pep 1 MKPKPHTVRT LIAAVLSLAL GGCFSAVVGG AAVGAKSVID RRTTGAQTDD 51NVMALRIETT ARSYLRQNNQ TKGYTPQISV VGYNRHLLLL GQVATEGEKQ 101 FVGQIARSEQAAEGVYNYIT VASLPRTAGD IAGDTWNTSK VRATLLGISP 151 ATQARVKIIT YGNVTYVMGILTPEEQAQIT QKVSTTVGVQ KVITLYQNYV 201 QR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2883>:

m936-1.seq 1 ATGAAACCCA AACCGCACAC CGTCCGCACC CTGATTGCCG CCATTTTCAG 51CCTTGCCCTT AGCGGCTGCG TCAGCGCAGT AATCGGAAGC GCCGCCGTCG 101 GCGCGAAATCCGCCGTCGAC CGCCGAACCA CCGGCGCGCA AACCGACGAC 151 AACGTTATGG CGTTGCGTATCGAAACCACC GCCCGTTCCT ATCTGCGCCA 201 AAACAACCAA ACCAAAGGCT ACACGCCCCAAATCTCCGTC GTCGGCTACA 251 ACCGCCACCT GCTGCTGCTC GGACAAGTCG CCACCGAAGGCGAAAAACAG 301 TTCGTCGGTC AGATTGCACG TTCCGAACAG GCCGCCGAAG GCGTGTACAA351 CTATATTACC GTCGCCTCCC TGCCGCGCAC TGCCGGCGAC ATCGCCGGCG 401ACACTTGGAA CACATCCAAA GTCCGCGCCA CGCTGTTGGG CATCAGCCCC 451 GCCACACAGGCGCGCGTCAA AATCGTTACC TACGGCAACG TAACCTACGT 501 TATGGGCATC CTCACCCCCGAAGAACAGGC GCAGATTACC CAAAAAGTCA 551 GCACCACCGT CGGCGTACAA AAAGTCATCACCCTCTACCA AAACTACGTC 601 CAACGCTGAThis corresponds to the amino acid sequence <SEQ ID 2884; ORF 936-1>:

m936-1.pep 1 MKPKPHTVRT LIAAIFSLAL SGCVSAVIGS AAVGAKSAVD RRTTGAQTDD 51NVMALRIETT ARSYLRQNNQ TKGYTPQISV VGYNRHLLLL GQVATEGEKQ 101 FVGQIARSEQAAEGVYNYIT VASLPRTAGD IAGDTWNTSK VRATLLGISP 151 ATQARVKIVT YGNVTYVMGILTPEEQAQIT QKVSTTVGVQ KVITLYQNYV 201 QR* m936-1/g936-1 95.5% identity in202 aa overlap        10        20        30        40        50        60 m936-1.pepMKPKPHTVRTLIAAIFSLALSGCVSAVIGSAAVGAKSAVDRRTTGAQTDDNVMALRIETT||||||||||||||::||||:|| |||:|:|||||||::||||||||||||||||||||| g936-1MKPKPHTVRTLIAAVLSLALGGCFSAVVGGAAVGAKSVIDRRTTGAQTDDNVMALRIETT        10        20        30        40        50        60        70        80        90       100        110      120 m936-1.pepARSYLRQNNQTKGYTPQISVVGYNRHLLLLGQVATEGEKQFVGQIARSEQAAEGVYNYIT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g936-1ARSYLRQNNQTKGYTPQISVVGYNRHLLLLGQVATEGEKQFVGQIARSEQAAEGVYNYIT        70        80        90       100       110       120       130       140       150       160       170       180 m936-1.pepVASLPRTAGDIAGDTWNTSKVRATLLGISPATQARVKIVTYGNVTYVMGILTPEEQAQIT||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||| g936-1VASLPRTAGDIAGDTWNTSKVRATLLGISPATQARVKIITYGNVTYVMGILTPEEQAQIT       130       140       150       160       170       180       190       200 m936-1.pep QKVSTTVGVQKVITLYQNYVQRX||||||||||||||||||||||| g936-1 QKVSTTVGVQKVITLYQNYVQRX       190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2885>:

a936-1.seq 1 ATGAAACCCA AACCGCACAC CGTCCGCACC CTGACTGCCG CCGTCCTCAG 51CCTTGCCCTC GGCGGCTGCG TCAGCGCAGT CGTCGGCGGC GCGGCGGTCG 101 GCGCGAAATCCGCCGTCGAC CGCCGAACCA CCGGCGCGCA AACCGACGAC 151 AACGTAATGG CGCTGCGTATCGAAACCACC GCCCGCTCCT ATCTGCGCCA 201 AAACAACCAA ACCAAAGGCT ACACGCCCCAAATCTCCGTT GTCGGCTACA 251 ACCGCCACCT GCTGCTGCTC GGACAAGTCG CCACCGAAGGCGAGAAACAG 301 TTCGTCGGTC AGATTGCACG TTCCGAACAG GCCGCCGAAG GCGTGTACAA351 CTACATTACC GTCGCCTCCC TGCCGCGCAC TGCCGGCGAC ATCGCCGGCG 401ACACTTGGAA CACATCCAAA GTCCGCGCCA CGCTGTTGGG CATCAGCCCC 451 GCCACACAGGCGCGCGTCAA AATCGTTACC TACGGCAACG TAACCTACGT 501 TATGGGCATC CTCACCCCCGAAGAACAGGC GCAGATTACC CAAAAAGTCA 551 GCACCACCGT CGGCGTACAA AAAGTCATCACCCTCTACCA AAACTACGTC 601 CAACGCTGAThis corresponds to the amino acid sequence <SEQ ID 2886; ORF 936-1.a>:

a936-1.pep 1 MKPKPHTVRT LTAAVLSLAL GGCVSAVVGG AAVGAKSAVD RRTTGAQTDD 51NVMALRIETT ARSYLRQNNQ TKGYTPQISV VGYNRHLLLL GQVATEGEKQ 101 FVGQIARSEQAAEGVYNYIT VASLPRTAGD IAGDTWNTSK VRATLLGISP 151 ATQARVKIVT YGNVTYVMGILTPEEQAQIT QKVSTTVGVQ KVITLYQNYV 201 QR* a936-1/m936-1 97.0% identity in202 aa overlap        10        20        30        40        50        60 m936-1.pepMKPKPHTVRTLIAAIFSLALSGCVSAVIGSAAVGAKSAVDRRTTGAQTDDNVMALRIETT||||||||||| ||::||||:||||||:|:|||||||||||||||||||||||||||||| a936-1MKPKPHTVRTLTAAVLSLALGGCVSAVVGGAAVGAKSAVDRRTTGAQTDDNVMALRIETT        10        20        30        40        50        60        70        80        90       100       110       120 m936-1.pepARSYLRQNNQTKGYTPQISVVGYNRHLLLLGQVATEGEKQFVGQIARSEQAAEGVYNYIT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a936-1ARSYLRQNNQTKGYTPQISVVGYNRHLLLLGQVATEGEKQFVGQIARSEQAAEGVYNYIT        70        80        90       100       110       120       130       140       150       160       170       180 m936-1.pepVASLPRTAGDIAGDTWNTSKVRATLLGISPATQARVKIVTYGNVTYVMGILTPEEQAQIT|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a936-1VASLPRTAGDIAGDTWNTSKVRATLLGISPATQARVKIVTYGNVTYVMGILTPEEQAQIT       130       140       150       160       170       180       190       200 m936-1.pep QKVSTTVGVQKVITLYQNYVQRX||||||||||||||||||||||| a936-1 QKVSTTVGVQKVITLYQNYVQRX       190       200The following partial DNA sequence was identified in N.gonorrhoeae <SEQID 2887>:

g937.seq 1 atGAAAAATA TTCTCTTAgt ATTTGTTAGC TTTGTGCCAT TATGTGTCCG 51CACTGATCTG CCGCTGAata tCGAAGACAT AATGaccgAC AAGGGAAAAT 101 GGAAactGGAAACTTccctt acctacctgA acaGCGAAAA cagCCGCGCC 151 GCACTTGCCT CACCGGTTTACATTCAGACC GGCTCCGCTT CCTTTATCCC 201 CGTCCCGACC GAAATTCAGG AAAACGGCAGCAATACCGAT ATGCTCGCCG 251 GCACGCTCGG TTTGCGCTAC GGACTGAccg GCAataccgACATTTACGGC 301 AGCGGCAGCT ATCTGTGGCA CGAAGAACGC AAACTCGacg GCAACGGCAA351 AACCCGCAAC AAACGGATGT CCGACATATC CGCCGGCATC AGCCACACCT 401TCCttaAAGa cgGCAAAAAT CCCGCACTCA TCGCTTTCCT CGAAAGCACG 451 GTTTACGAAAAATCGCGCAA CAAAGCCTCG TCGGGAAAAT CGTGGCTCAT 501 CGGCGCCACC ACCTACAAAGCCATAGATCC GATTGTCCTT TCCCTCACCG 551 CCGCCTACCG CATCAACGGC AGCAAAACCCTTTCAGACGA CGTCAAATAC 601 AAAGCAGGCA ATTACTGGAT GCTGAATCCC AACATCTCATTTGCCGCCAA 651 CGACAGAATC AGCCTGACCG GAGGCATCCA ATGGCTGGGC AAACAGCCCG701 ACCGCATAGA CGGCAAAAAA GAATCCGCAA GAAACACATC CACCTACGCC 751CATTTCGGCG CAGGTTTCGG TTTCACCAAA ACCGCGGCTT TAAACGCATC 801 CGCACGTTTCAACGTTTCAG GGCAAAGCAG TTCCGAACTG AAATTGGGCG 851 TACAGCATAC ATTTTAAThis corresponds to the amino acid sequence <SEQ ID 2888; ORF 937.ng>:

g937.pep 1 MKNILLVFVS FVPLCVRTDL PLNIEDIMTD KGKWKLETSL TYLNSENSRA 51ALASPVYIQT GSASFIPVPT EIQENGSNTD MLAGTLGLRY GLTGNTDIYG 101 SGSYLWHEERKLDGNGKTRN KRMSDISAGI SHTFLKDGKN PALIAFLEST 151 VYEKSRNKAS SGKSWLIGATTYKAIDPIVL SLTAAYRING SKTLSDDVKY 201 KAGNYWMLNP NISFAANDRI SLTGGIQWLGKQPDRIDGKK ESARNTSTYA 251 HFGAGFGFTK TAALNASARF NVSGQSSSEL KLGVQHTF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2889>:

m937.seq 1 ATGAAGCGCA TCTTTTTGCC CGCCTTGCCC GCCATCCTGC CTTTATCCAC 51TTATGCCGAC CTGCCCTTGA CGATTGAAGA CATAATGACC GACAAGGGAA 101 AATGGAAACTGGAAACTTCC CTTACCTACC TGAACAGCGA AAACAACCGC 151 GCCGAACTTG CCGCACCGGTTTACATTCAA ACCGGCGCAA CCTCGTTTAT 201 CCCCATTCCG ACCGAAATCC AAgAAAaCGGCAGCAATACC GATATGCTCG 251 TCGGCACGCT CGGTTTGCGC TACGGACTGA CCGGGAATACCGACATTTAC 301 GGCAGCGGCA GCTATCTGTG GCACGAAGAA CGCAAACTCG ACGGCAACAG351 CAAAACCCGC AACAAACGGA TGTCCGACGT ATCCCTCGGC ATCAGCCACA 401CTTTCCTTAA AGACGACAAA AACCCCGCCC TAATCAGCTT TCTTGAAAGC 451 ACGGTTTACGAAAAATCGCG CAACAAAGCC TCGTCGGGAA AATCCTGGCT 501 CATCGGCGCC ACCACCTACAAAGCCATAGA TCCGATTGTC CTTTCCTTAA 551 CCGCCGCCTA CCGCATCAAC GGCAGCAAAACCCTTTCAGA CGGCATCCGC 601 TACAAATCGG GCAACTACCT GCTGCTCAAC CCCAACATCTCATTTGCTGC 651 CAACGACAGA ATCAGCCTGA CCGGAGGCAT CCAATGGCTG GGCAGGCAGC701 CCGACCGGAC GGACGGCAAA CGGGAATCCT CCAGAAACAC ATCCACCTAC 751GCCCATTTCG GCGCAGGTTT CGGTTTCACC AAAACCACGG CTTTAAACGC 801 ATCCGCACGTTTCAACGTTT CAGGGCAAAG CAGTTCCGAA CTGAAATTTG 851 GCGTACAGCA TACATTTTAAThis corresponds to the amino acid sequence <SEQ ID 2890; ORF 937>:

m937.pep.. 1 MKRIFLPALP AILPLSTYAD LPLTIEDIMT DKGKWKLETS LTYLNSENNR 51AELAAPVYIQ TGATSFIPIP TEIQENGSNT DMLVGTLGLR YGLTGNTDIY 101 GSGSYLWHEERKLDGNSKTR NKRMSDVSLG ISHTFLKDDK NPALISFLES 151 TVYEKSRNKA SSGKSWLIGATTYKAIDPIV LSLTAAYRIN GSKTLSDGIR 201 YKSGNYLLLN PNISFAANDR ISLTGGIQWLGRQPDRTDGK RESSRNTSTY 251 AHFGAGFGFT KTTALNASAR FNVSGQSSSE LKFGVQHTF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N.gonorrhoeaeORF 937 shows 86.9% identity over a 289 aa overlap with a predicted ORF(ORF 937.ng) from N. gonorrhoeae:

g937/m937            10        20        30        40        50       59g937.pep   MKNILL-VFVSFVPLCVRTDLPLNIEDIMTDKGKWKLETSLTYLNSENSRAALASPVYIQ  || |:| :: :::|| : :||||:||||||||||||||||||||||||:|| ||:||||| m937  MKRIFLPALPAILPLSTYADLPLTIEDIMTDKGKWKLETSLTYLNSENNRAELAAPVYIQ          10        20        30        40        50        60 60        70        80        90       100       110      119 g937.pep  TGSASFIPVPTEIQENGSNTDMLAGTLGLRYGLTGNTDIYGSGSYLWHEERKLDGNGKTR   ||::||||:||||||||||||||:||||||||||||||||||||||||||||||||:||| m937  TGATSFIPIPTEIQENGSNTDMLVGTLGLRYGLTGNTDIYGSGSYLWHEERKLDGNSKTR          70        80        90       100       110       120120       130       140       150       160       170      179 g937.pep  NKRMSDISAGISHTFLKDGKNPALIAFLESTVYEKSRNKASSGKSWLIGATTYKAIDPIV  ||||||:| ||||||||| ||||||:|||||||||||||||||||||||||||||||||| m937  NKRMSDVSLGISHTFLKDDKNPALISFLESTVYEKSRNKASSGKSWLIGATTYKAIDPIV         130       140       150       160       170       180180       190       200       210       220       230      239 g937.pep  LSLTAAYRINGSKTLSDDVKYKAGNYWMLNPNISFAANDRISLTGGIQWLGKQPDRIDGK  ||||||||||||||||| ::||:||| :|||||||||||||||||||||||:|||| ||| m937  LSLTAAYRINGSKTLSDGIRYKSGNYLLLNPNISFAANDRISLTGGIQWLGRQPDRTDGK         190       200       210       220       230       240240     250       260       270       280       289 g937.pep  KESARNTSTYAHFGAGFGFTKTAALNASARFNVSGQSSSELKLGVQHTFX  :||:||||||||||||||||||:|||||||||||||||||||:||||||| m937  RESSRNTSTYAHFGAGFGFTKTTALNASARFNVSGQSSSELKFGVQHTFX         250       260       270       280The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2891>:

a937.seq 1 ATGAAGCGCA TCTTTTTGCC CGCCTTGCCC GCCATCCTGC CTTTATCCGC 51TTATGCCGAC CTGCCCTTGA CGATTGAAGA CATAATGACC GACAAGGGCA 101 AATGGAAACTGGAAACTTCC CTTACCTACC TGAACAGCGA AAACAACCGC 151 GCCGAACTTG CCGCACCGGTTTACATCCAA ACCGGCGCAA CCTCGTTTAT 201 CCCCATTCCG ACCGAAATCC AAGAAAACGGCAGCAATACC GATATGCTCG 251 TTGGCACGCT CGGTTTGCGC TACGGACTGA CCGGGAATACCGACATTTAC 301 GGCAGCGGCA GCTATCTGTG GCACGAAGAA CGCAAACTCG ACGGCAACGG351 CAAAACCCGA AACAAACGGA TGTCCGACGT ATCCCTCGGC ATCAGCCACA 401CCTTCCTTAA AGACGACAAA AACCCCGCCC TAATCAGCTT TCTTGAAAGC 451 ACGGTTTACGAAAAATCGCG CAACAAAGCC TCGTCGGGAA AATCCTGGCT 501 CATCGGCGCC ACCACCTACAAAGCCATCGA CCCCGTCGTC CTCTCATTGA 551 CCGCTGCCTA CCGTATCAAC GGCAGCAAAACCCTTTCAAG CAACACCAAA 601 TACAAAGCAG GCAATTACTG GATGCTGAAT CCCAATATATCCTTCGCCGC 651 CAACGACAGA ATCAGCCTCA CGGGCGGCAT CCAATGGCTG GGCAAGCAGC701 CCGACCGTCT GGACGGCAAA AAAGAATCCG CAAGAAACAC ATCCACCTAT 751GCCCATTTCG GCGCAGGTTT CGGTTTCACC AAAACCACGG CTTTAAACGC 801 ATCCGCACGTTTCAACGTTT CAGGGCAAAG CAGTTCCGAA CTGAAATTTG 851 GCGTACAGCA TACGTTTTAAThis corresponds to the amino acid sequence <SEQ ID 2892; ORF 937.a>:

a937.pep 1 MKRIFLPALP AILPLSAYAD LPLTIEDIMT DKGKWKLETS LTYLNSENNR 51AELAAPVYIQ TGATSFIPIP TEIQENGSNT DMLVGTLGLR YGLTGNTDIY 101 GSGSYLWHEERKLDGNGKTR NKRMSDVSLG ISHTFLKDDK NPALISFLES 151 TVYEKSRNKA SSGKSWLIGATTYKAIDPVV LSLTAAYRIN GSKTLSSNTK 201 YKAGNYWMLN PNISFAANDR ISLTGGIQWLGKQPDRLDGK KESARNTSTY 251 AHFGAGFGFT KTTALNASAR FNVSGQSSSE LKFGVQHTF*m937/a937 95.2% identity in 289 aa overlap        10        20        30        40        50        60 m937.pepMKRIFLPALPAILPLSTYADLPLTIEDIMTDKGKWKLETSLTYLNSENNRAELAAPVYIQ||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||| a937MKRIFLPALPAILPLSAYADLPLTIEDIMTDKGKWKLETSLTYLNSENNRAELAAPVYIQ        10        20        30        40        50        60        70        80        90       100       110       120 m937.pepTGATSFIPIPTEIQENGSNTDMLVGTLGLRYGLTGNTDIYGSGSYLWHEERKLDGNSKTR||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||| a937TGATSFIPIPTEIQENGSNTDMLVGTLGLRYGLTGNTDIYGSGSYLWHEERKLDGNGKTR        70        80        90       100       110       120       130       140       150       160       170       180 m937.pepNKRMSDVSLGISHTFLKDDKNPALISFLESTVYEKSRNKASSGKSWLIGATTYKAIDPIV||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:| a937NKRMSDVSLGISHTFLKDDKNPALISFLESTVYEKSRNKASSGKSWLIGATTYKAIDPVV       130       140       150       160       170       180       190       200       210       220       230       240 m937.pepLSLTAAYRINGSKTLSDGIRYKSGNYLLLNPNISFAANDRISLTGGIQWLGRQPDRTDGK||||||||||||||||:: :||:||| :|||||||||||||||||||||||:|||| ||| a937LSLTAAYRINGSKTLSSNTKYKAGNYWMLNPNISFAANDRISLTGGIQWLGKQPDRLDGK       190       200       210       220       230       240       250       260       270       280       290 m937.pepRESSRNTSTYAHFGAGFGFTKTTALNASARFNVSGQSSSELKFGVQHTFX:||:|||||||||||||||||||||||||||||||||||||||||||||| a937KESARNTSTYAHFGAGFGFTKTTALNASARFNVSGQSSSELKFGVQHTFX       250       260       270       280       290

g939.seq not found yet

g939.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2893>:

m939.seq (partial) 1 ATGAAACGAT TGACTTTATT GGCCTTTGTT TTGGCTGCCGGTGCGGTTTC 51 CGCCTCTCCC AAAGCAGACG TGGAAAAAGG CAAACAGGTT GCCGCAACGG 101TTTGTGCGGC TTGCCATGCA GCAGACGGTA ACAGCGGCAT TGCGATGTAT 151 CCGCGTTTGGCGGCACAGCA TACTGCTTAC ATCTATCATC AAACTATCGG 201 CATCCGCGAC GTAAACGCACCC...This corresponds to the amino acid sequence <SEQ ID 2894; ORF 939>:

m939.pep (partial) 1 MKRLTLLAFV LAAGAVSASP KADVEKGKQV AATVCAACHAADGNSGIAMY 51 PRLAAQHTAY IYHQTIGIRD VNAP...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2895>:

a939.seq 1 ATGAAACGAT TGACTTTATT GGCCTTTGTT TTGGCTGCCG GTGCGGTTTC 51CGCATCTCCC AAAGCAGACG TGGAAAAAGG CAAACAGGTT GCCGCAACGG 101 TTTGTGCGGCTTGCCATGCA GCAGACGGTA ACAGCGGCAT TGCGATGTAT 151 CCGCGTTTGG CGGCACAGCATACTGCTTAC ATCTATCATC AAACCATCGG 201 CATCCGCGAC GGTAAACGCA CCCACGGTTCGGCAGCTGTG ATGAAACCGG 251 TGGTAATGAA TTTGAGCGAT CAGGATATTT TGAACGTATCCGCATTCTAT 301 GCCAAACAGC AGCCCAAATC CGGTGAAGCC AATCCTAAGG AAAATCCCGA351 ATTGGGTGCG AAAATCTATC GCGGCGGTTT GAGCGATAAA AAAGTGCCGG 401CGTGTATGTC CTGCCACGGT CCGAGCGGTG CGGGTATGCC GGGGGGCGGA 451 AGCGAAATTCAGGCTTATCC GCGTTTGGGC GGTCAGCATC AGGCATATAT 501 TGTTGAACAG ATGAATGCCTACAAGTCCGG TCAGCGTAAA AATACCATCA 551 TGGAAGATAT TGCAAACCGT ATGTCTGAAGAAGATTTGAA AGCGGTCGCC 601 AACTTTATCC AAGGTTTGCG TTAAThis corresponds to the amino acid sequence <SEQ ID 2896; ORF 939.a>:

a939.pep 1 MKRLTLLAFV LAAGAVSASP KADVEKGKQV AATVCAACHA ADGNSGIAMY 51PRLAAQHTAY IYHQTIGIRD GKRTHGSAAV MKPVVMNLSD QDILNVSAFY 101 AKQQPKSGEANPKENPELGA KIYRGGLSDK KVPACMSCHG PSGAGMPGGG 151 SEIQAYPRLG GQHQAYIVEQMNAYKSGQRK NTIMEDIANR MSEEDLKAVA 201 NFIQGLR* m939/a939 100.0% identityin 70 aa overlap        10        20        30        40        50        60 m939.pepMKRLTLLAFVLAAGAVSASPKADVEKGKQVAATVCAACHAADGNSGIAMYPRLAAQHTAY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a939MKRLTLLAFVLAAGAVSASPKADVEKGKQVAATVCAACHAADGNSGIAMYPRLAAQHTAY        10        20        30        40        50        60         70m939.pep IYHQTIGIRDVNAP |||||||||| a939IYHQTIGIRDGKRTHGSAAVMKPVVMNLSDQDILNVSAFYAKQQPKSGEANPKENPELGA        70        80        90       100       110       120The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2897>:

g950.seq 1 ATGAACAAAA ATATTGCTGC CGCACTCGCC GGTGCTTTAT CCCTGTCTCT 51GGCCGCCGGC GCCGTTGCCG CCCACAAACC GGCAAGCAAC GCAACAGGCG 101 TTCAAAAATCCGCCCAAGGC TCTTGCGGCG CATCCAAATC TGCCGAAGGT 151 TCGTGCGGCG CATCCAAATCTGCCGAAGGT TCGTGCGGCG CGGCTGCTTC 201 TAAAGCAGGC GAAGGCAAAT GCGGCGAGGGCAAATGCGGT GCAACTGTAA 251 AAAAAGCCCA CAAACACACC AAAGCATCTA AAGCCAAAGCCAAATCTGCC 301 GAAGGCAAAT GCGGCGAAGG CAAATGCGGT TCTAAATAAThis corresponds to the amino acid sequence <SEQ ID 2898; ORF 950.ng>:

g950.pep 1 MNKNIAAALA GALSLSLAAG AVAAHKPASN ATGVQKSAQG SCGASKSAEG 51SCGASKSAEG SCGAAASKAG EGKCGEGKCG ATVKKAHKHT KASKAKAKSA 101 EGKCGEGKCGSK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2899>:

m950.seq 1 ATGAACAAAA ACATTGCTGC CGCTCTCGCC GGTGCTTTAT CCCTGTCTTT 51GGCCGCCGGT GCAGTTGCTG CCAACAAACC GGCAAGCAAC GCAACAGGCG 101TTCATAAATC CGCCCATGGC TCTTGCGGCG CGTCCAAATC TGCCGAAGGT 151TCGTGCGGCG CGGCTGGTTC TAAAGCAGGC GAAGGCAAAT GCGGCGAGGG 201CAAATGCGGT GCGACCGTAA AAAAAACCCA CAAACACACC AAAGCATCTA 251AAGCCAAGGC CAAATCTGCC GAAGGCAAAT GCGGCGAAGG CAAATGCGGT 301 TCTAAATAAThis corresponds to the amino acid sequence <SEQ ID 2900; ORF 950>:

m950.pep 1 MNKNIAAALA GALSLSLAAG AVAANKPASN ATGVHKSAHG SCGASKSAEG 51SCGAAGSKAG EGKCGEGKCG ATVKKTHKHT KASKAKAKSA EGKCGEGKCG 101 SKComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 950 shows 86.6% identity over a 112 aa overlap with a predicted ORF(ORF 950) from N. gonorrhoeae

m950/g950 86.6% identity in 112 aa overlap        10        20        30        40        50 m950.pepMNKNIAAALAGALSLSLAAGAVAANKPASNATGVHKSAHGSCGASKSAEGSCGA------||||||||||||||||||||||||:|||||||||:|||:||||||||||||||| g950MNKNIAAALAGALSLSLAAGAVAAHKPASNATGVQKSAQGSCGASKSAEGSCGASKSAEG        10        20        30        40        50        60        60        70        80        90       100 m950.pep----AGSKAGEGKCGEGKCGATVKKTHKHTKASKAKAKSAEGKCGEGKCGSK    |:|||||||||||||||||||:|||||||||||||||||||||||||| g950SCGAAASKAG EGKCGEGKCG ATVKKAHKHT KASKAKAKSA EGKCGEGKCG SKX        70        80        90       100       110The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2901>:

a950.seq 1 ATGAACAAAA ACATTGCTGC CGCACTCGCC GGTGCTTTAT CCCTGTCTTT 51GGCCGCCGGT GCAGTTGCTG CCAACAAACC GGCAAGCAAC GCAACAGGCG 101TTCATAAATC CGCCCATGGC TCTTGCGGCG CGTCCAAATC TGCCGAAGGT 151TCGTGCGGCG CGGCTGGTTC TAAAGCAGGC GAAGGCAAAT GCGGCGAGGG 201CAAATGCGGT GCGACCGTAA AAAAAACCCA CAAACACACC AAAGCATCTA 251AAGCCAAGGC CAAATCTGCC GAAGGCAAAT GCGGCGAAGG CAAATGCGGT 301 TCTAAATAAThis corresponds to the amino acid sequence <SEQ ID 2902; ORF 950.a>:

a950.pep 1 MNKNIAAALA GALSLSLAAG AVAANKPASN ATGVHKSAHG SCGASKSAEG 51SCGAAGSKAG EGKCGEGKCG ATVKKTHKHT KASKAKAKSA EGKCGEGKCG 101 SK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 950 shows 100.0% identity over a 102 aa overlap with a predicted ORF(ORF 950) from N. meningitidis

a950/m950 100.0% identity in 102 aa overlap        10        20        30        40        50        60 a950.pepMNKNIAAALAGALSLSLAAGAVAANKPASNATGVHKSAHGSCGASKSAEGSCGAAGSKAG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m950MNKNIAAALAGALSLSLAAGAVAANKPASNATGVHKSAHGSCGASKSAEGSCGAAGSKAG        10        20        30        40        50        60        70        80        90       100 a950.pepEGKCGEGKCGATVKKTHKHTKASKAKAKSAEGKCGEGKCGSKX|||||||||||||||||||||||||||||||||||||||||| m950EGKCGEGKCGATVKKTHKHTKASKAKAKSAEGKCGEGKCGSK        70        80        90       100The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2903>:

g951.seq 1 ATGATTATGT TACCCGCCCG TTTCACTATT TTATCTGTCC TCGCAGCAGC 51CCTGCTTGCC GGACAGGCGT ATGCTGCCGG CGCGGCGGAT GTGGAGCTGC 101CGAAGGAAGT CGGAAAGGTT TTAAGGAAAC ATCGGCGTTA CAGCGAGGAA 151GAAATCAAAA ACGAACGCGC ACGGCTTGCG GCAGTGGGCG AACGGGTCAA 201CAGGGTGTTT ACGCTGTTGG GCGGTGAAAC GGCTTTGCAG AAAGGGCAGG 251CGGGAACGGC TCTGGCAACC TATATGCTGA TGTTGGAACG CACAAAATCC 301CCCGAAGTCG CCGAACGCGC CTTGGAAATG GCCGTGTCGC TGAACGCGTT 351TGAACAGGCG GAAATGATTT ATCAGAAATG GCGGCAGATC GAGCCTATAC 401CGGGTGAGGC GCAAAAACGG GCGGGGTGGC TGCGGAACGT ATTGAGGGAA 451GGGGGAAATC AGCATCTGGA CGGGTTGGAA GAGGTGCTGG CGCAATCGGA 501CGATGTGCAA AAACGCAGGA TATTTTTGCT GCTGGTGCAA GCCGCCGTGC 551AGCAGGGTGG GGTGGCTCAA AAAGCATCGA AAGCGGTTCG CCGTGCGGCG 601TTGAAGTATG AACATCTGCC CGAAGCGGCG GTTGCCGATG CGGTGTTCGG 651CGTACAGGGA CGCGAAAAGG AAAAGGCAAT CGAAGCTTTG CAGCGTTTGG 701CGAAGCTCGA TACGGAAATA TTGCCCCCCA CTTTAATGAC GTTGCGTCTG 751ACTGCACGCA AATATCCCGA AATACTCGAC GGCTTTTTCG AGCAGACAGA 801CACCCAAAAC CTTTCGGCCG TCTGGCAGGA AATGGAAATT ATGAATCTGG 851TTTCCCTGCG TAAGCCGGAT GATGCCTATG CGCGTTTGAA CGTGCTGTTG 901GAACACAACC CGAATGCAAA CCTGTATATT CAGGCGGCGA TATTGGCGGC 951AAACCGAAAA GAAGGTGCGT CCGTTATCGA CGGCTACGCC GAAAAGGCAT 1001ACGGCAGGGG GACGGGGGAA CAGCGGGGCA GGGCGGCAAT GACGGCGGCG 1051ATGATATATG CCGACCGCAG GGATTACGCC AAAGTCAGGC AGTGGTTGAA 1101AAAAGTGTCC GCGCCGGAAT ACCTGTTCGA CAAAGGCGTG CTGGCGGCTG 1151CGGCGGCTGC CGAATTGGAC GGAGGCCGGG CGGCTTTGCG GCAGATCGGC 1201AGGGTGCGGA AACTTCCCGA ACAGCAGGGG CGGTATTTTA CGGCAGACAA 1251TTTGTCCAAA ATACAGATGC TCGCCCTGTC GAAGCTGCCC GACAAACGGG 1301AAGCCCTGAT CGGGCTGAAC AACATCATCG CCAAACTTTC GGCGGCGGGA 1351AGCACGGAAC CTTTGGCGGA AGCATTGGCA CAGCGTTCCA TTATTTACGA 1401ACAGTTCGGC AAACGGGGAA AAATGATTGC CGACCTTGAA ACCGCGCTCA 1451AACTTACGCC CGATAATGCA CAAATTATGA ATAATCTGGG CTACAGCCTG 1501CTTTCCGATT CCAAACGTTT GGACGAGGGT TTCGCCCTGC TTCAGACGGC 1551ATACCAAATC AACCCGGACG ATACCGCCGT TAACGACAGC ATAGGCTGGG 1601CGTATTACCT GAAAGGCGAC GCGGAAAGCG CGCTGCCGTA TCTGCGGTAT 1651TCGTTTGAAA ACGACCCCGA GCCCGAAGTT GCCGCCCATT TGGGCGAAGT 1701GTTGTGGGCA TTGGGCGAAC GCGATCAGGC GGTTGACGTA TGGACGCAGG 1751CGGCACACCT TAGGGGAGAC AAGAAAATAT GGCGGGAGAC GCTCAAACGC 1801TACGGAATCG CCTTGCCCGA GCCTTCCCGA AAACCCCGGA AATAAThis corresponds to the amino acid sequence <SEQ ID 2904; ORF 951.ng>:

g951.pep 1 MIMLPARFTI LSVLAAALLA GQAYAAGAAD VELPKEVGKV LRKHRRYSEE 51EIKNERARLA AVGERVNRVF TLLGGETALQ KGQAGTALAT YMLMLERTKS 101PEVAERALEM AVSLNAFEQA EMIYQKWRQI EPIPGEAQKR AGWLRNVLRE 151GGNQHLDGLE EVLAQSDDVQ KRRIFLLLVQ AAVQQGGVAQ KASKAVRRAA 201LKYEHLPEAA VADAVFGVQG REKEKAIEAL QRLAKLDTEI LPPTLMTLRL 251TARKYPEILD GFFEQTDTQN LSAVWQEMEI MNLVSLRKPD DAYARLNVLL 301EHNPNANLYI QAAILAANRK EGASVIDGYA EKAYGRGTGE QRGRAAMTAA 351MIYADRRDYA KVRQWLKKVS APEYLFDKGV LAAAAAAELD GGRAALRQIG 401RVRKLPEQQG RYFTADNLSK IQMLALSKLP DKREALIGLN NIIAKLSAAG 451STEPLAEALA QRSIIYEQFG KRGKMIADLE TALKLTPDNA QIMNNLGYSL 501LSDSKRLDEG FALLQTAYQI NPDDTAVNDS IGWAYYLKGD AESALPYLRY 551SFENDPEPEV AAHLGEVLWA LGERDQAVDV WTQAAHLRGD KKIWRETLKR 601YGIALPEPSR KPRK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2905>:

m951.seq 1 ATGATTATGT TACCTAACCG TTTCAAAATG TTAACTGTGT TGACGGCAAC 51CTTGATTGCC GGACAGGTAT CTGCCGCCGG AGGCGGTGCG GGGGATATGA 101AACAGCCGAA GGAAGTCGGA AAGGTTTTCA GAAAGCAGCA GCGTTACAGC 151GAGGAAGAAA TCAAAAACGA ACGCGCACGG CTTGCGGCAG TGGGCGAGCG 201GGTTAATCAG ATATTTACGT TGCTGGGAGG GGAAACCGCC TTGCAAAAGG 251GGCAGGCGGG AACGGCTCTG GCAACCTATA TGCTGATGTT GGAACGCACA 301AAATCCCCCG AAGTCGCCGA ACGCGCCTTG GAAATGGCCG TGTCGCTGAA 351CGCGTTTGAA CAGGCGGAAA TGATTTATCA GAAATGGCGG CAGATTGAGC 401CTATACCGGG TAAGGCGCAA AAACGGGCGG GGTGGCTGCG GAACGTGCTG 451AGGGAAAGAG GAAATCAGCA TCTGGACGGA CTGGAAGAAG TGCTGGCTCA 501GGCGGACGAA GGACAGAACC GCAGGGTGTT TTTATTGTTG GCACAAGCCG 551CCGTGCAACA GGACGGGTTG GCGCAAAAAG CATCGAAAGC GGTTCGCCGC 601GCGGCGTTGA AATATGAACA TCTGCCCGAA GCGGCGGTTG CCGATGTGGT 651GTTCAGCGTA CAGGGACGCG AAAAGGAAAA GGCAATCGGA GCTTTGCAGC 701GTTTGGCGAA GCTCGATACG GAAATATTGC CCCCCACTTT AATGACGTTG 751CGTCTGACTG CACGCAAATA TCCCGAAATA CTCGACGGCT TTTTCGAGCA 801GACAGACACC CAAAACCTTT CGGCCGTCTG GCAGGAAATG GAAATTATGA 851ATCTGGTTTC CCTGCACAGG CTGGATGATG CCTATGCGCG TTTGAACGTG 901CTGTTGGAAC GCAATCCGAA TGCAGACCTG TATATTCAGG CAGCGATATT 951GGCGGCAAAC CGAAAAGAAG GTGCTTCCGT TATCGACGGC TACGCCGAAA 1001AGGCATACGG CAGGGGGACG GAGGAACAGC GGAGCAGGGC GGCGCTAACG 1051GCGGCGATGA TGTATGCCGA CCGCAGGGAT TACGCCAAAG TCAGGCAGTG 1101GCTGAAAAAA GTATCCGCGC CGGAATACCT GTTCGACAAA GGTGTGCTGG 1151CGGCTGCGGC GGCTGTCGAG TTGGACGGCG GCAGGGCGGC TTTGCGGCAG 1201ATCGGCAGGG TGCGGAAACT TCCCGAACAG CAGGGGCGGT ATTTTACGGC 1251AGACAATTTG TCCAAAATAC AGATGCTCGC CCTGTCGAAG CTGCCCGATA 1301AACGGGAGGC TTTGAGGGGG TTGGACAAGA TTATCGAAAA ACCGCCTGCC 1351GGCAGTAATA CAGAGTTACA GGCAGAGGCA TTGGTACAGC GGTCAGTTGT 1401TTACGATCGG CTTGGCAAGC GGAAAAAAAT GATTTCAGAT CTTGAAAGGG 1451CGTTCAGGCT TGCACCCGAT AACGCTCAGA TTATGAATAA TCTGGGCTAC 1501AGCCTGCTGA CCGATTCCAA ACGTTTGGAC GAAGGTTTCG CCCTGCTTCA 1551GACGGCATAC CAAATCAACC CGGACGATAC CGCTGTCAAC GACAGCATAG 1601GCTGGGCGTA TTACCTGAAA GGCGACGCGG AAAGCGCGCT GCCGTATCTG 1651CGGTATTCGT TTGAAAACGA CCCCGAGCCC GAAGTTGCCG CCCATTTGGG 1701CGAAGTGTTG TGGGCATTGG GCGAACGCGA TCAGGCGGTT GACGTATGGA 1751CGCAGGCGGC ACACCTTACG GGAGACAAGA AAATATGGCG GGAAACGCTC 1801AAACGTCACG GCATCGCATT GCCCCAACCT TCCCGAAAAC CTCGGAAATA 1851 AThis corresponds to the amino acid sequence <SEQ ID 2906; ORF 791>:

m951.pep 1 MIMLPNRFKM LTVLTATLIA GQVSAAGGGA GDMKQPKEVG KVFRKQQRYS 51EEEIKNERAR LAAVGERVNQ IFTLLGGETA LQKGQAGTAL ATYMLMLERT 101KSPEVAERAL EMAVSLNAFE QAEMIYQKWR QIEPIPGKAQ KRAGWLRNVL 151RERGNQHLDG LEEVLAQADE GQNRRVFLLL AQAAVQQDGL AQKASKAVRR 201AALKYEHLPE AAVADVVFSV QGREKEKAIG ALQRLAKLDT EILPPTLMTL 251RLTARKYPEI LDGFFEQTDT QNLSAVWQEM EIMNLVSLHR LDDAYARLNV 301LLERNPNADL YIQAAILAAN RKEGASVIDG YAEKAYGRGT EEQRSRAALT 351AAMMYADRRD YAKVRQWLKK VSAPEYLFDK GVLAAAAAVE LDGGRAALRQ 401IGRVRKLPEQ QGRYFTADNL SKIQMLALSK LPDKREALRG LDKIIEKPPA 451GSNTELQAEA LVQRSVVYDR LGKRKKMISD LERAFRLAPD NAQIMNNLGY 501SLLTDSKRLD EGFALLQTAY QINPDDTAVN DSIGWAYYLK GDAESALPYL 551RYSFENDPEP EVAAHLGEVL WALGERDQAV DVWTQAAHLT GDKKIWRETL 601KRHGIALPQP SRKPRK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 951 shows 88.6% identity over a 616 aa overlap with a predicted ORF(ORF 951) from N. gonorrhoeae

m951/g951 88.6% identity in 616 aa overlap         10        20        30        40        50        60 m951.pep MIMLPNRFKMLTVLTATLIAGQVSAAGGGAGDMKQPKEVGKVERKQQRYSEEEIKNERAR  ||||| ||:|:||:|:|:|||: ||  ||:|:: |||||||:||::||||||||||||| g951 MIMLPARFTILSVLAAALLAGQAYAA--GAADVELPKEVGKVLRKHRRYSEEEIKNERAR         10        20          30        40        50         70        80        90       100       110       120 m951.pep LAAVGERVNQIFTLLGGETALQKGQAGTALATYMLMLERTKSPEVAERALEMAVSLNAFE |||||||||::||||||||||||||||||||||||||||||||||||||||||||||||| g951 LAAVGERVNRVETLLGGETALQKGQAGTALATYMLMLERTKSPEVAERALEMAVSLNAFE 60        70        80        90       100       110        130       140       150       160       170       180 m951.pep QAEMIYQKWRQIEPIPGKAQKRAGWLRNVLRERGNQHLDGLEEVLAQADEGQNRRVFLLL |||||||||||||||||:|||||||||||||| ||||||||||||||:|: |:||:|||| g951 QAEMIYQKWRQIEPIPGEAQKRAGWLRNVLREGGNQHLDGLEEVLAQSDDVQKRRIFLLL120       130       140       150       160       170        190       200       210       220       230       240 m951.pep AQAAVQQDGLAQKASKAVRRAALKYEHLPEAAVADVVFSVQGREKEKAIGALQRLAKLDT  :|||||||:|||||||||||||||||||||||||:||:|||||||||| |||||||||| g951 VQAAVQQGGVAQKASKAVRRAALKYEHLPEAAVADAVFGVQGREKEKAIEALQRLAKLDT180       190       200       210       220       230        250       260       270       280       290       300 m951.pep EILPPTLMTLRLTARKYPEILDGFFEQTDTQNLSAVWQEMEIMNLVSLHRLDDAYARLNV ||||||||||||||||||||||||||||||||||||||||||||||||:: ||||||||| g951 EILPPTLMTLRLTARKYPEILDGFFEQTDTQNLSAVWQEMEIMNLVSLRKPDDAYARLNV240       250       260       270       280       290        310       320       330       340       350       360 m951.pep LLERNPNADLYIQAAILAANRKEGASVIDGYAEKAYGRGTEEQRSRAALTAAMMYADRRD |||:||||:||||||||||||||||||||||||||||||| |||:|||:||||:|||||| g951 LLEHNPNANLYIQAAILAANRKEGASVIDGYAEKAYGRGTGEQRGRAAMTAAMIYADRRD300       310       320       330       340       350        370       380       390       400       410       420 m951.pep YAKVRQWLKKVSAPEYLFDKGVLAAAAAVELDGGRAALRQIGRVRKLPEQQGRYFTADNL ||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||| g951 YAKVRQWLKKVSAPEYLFDKGVLAAAAAAELDGGRAALRQIGRVRKLPEQQGRYFTADNL360       370       380       390       400       410        430       440       450       460       470       480 m951.pep SKIQMLALSKLPDKREALRGLDKIIEKPPAGSNTELQAEALVQRSVVYDRLGKRKKMISD |||||||||||||||||| ||::|| |  |:::||  ||||:|||::|:::||| |||:| g951 SKIQMLALSKLPDKREALIGLNNIIAKLSAAGSTEPLAEALAQRSIIYEQFGKRGKMIAD420       430       440       450       460       470        490       500       510       520       530       540 m951.pep LERAFRLAPDNAQIMNNLGYSLLTDSKRLDEGFALLQTAYQINPDDTAVNDSIGWAYYLK  |||::|:|||||||||||||||:|||||||||||||||||||||||||||||||||||| g951 LETALKLTPDNAQIMNNLGYSLLSDSKRLDEGFALLQTAYQINPDDTAVNDSIGWAYYLK480       490       500       510       520       530        550       560       570       580       590       600 m951.pep GDAESALPYLRYSFENDPEPEVAAHLGEVLWALGERDQAVDVWTQAAHLTGDKKIWRETL ||||||||||||||||||||||||||||||||||||||||||||||||| |||||||||| g951 GDAESALPYLRYSFENDPEPEVAAHLGEVLWALGERDQAVDVWTQAAHLRGDKKIWRETL540       550       560       570       580       590         610m951.pep  KRHGIALPQPSRKPRK  ||:|||||:||||||| g951  KRYGIALPEPSRKPRKX600       610The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2907>:

a951.seq 1 ATGTTACCCG CCCGTTTCAC CATTTTATCT GTGCTCGCGG CAGCCCTGCT 51TGCCGGGCAG GCGTATGCCG CCGGCGCGGC GGATGCGAAG CCGCCGAAGG 101AAGTCGGAAA GGTTTTCAGA AAGCAGCAGC GTTACAGCGA GGAAGAAATC 151AAAAACGAAC GCGCACGGCT TGCGGCAGTG GGCGAGCGGG TTAATCAGAT 201ATTTACGTTG CTGGGAGGGG AAACCGCCTT GCAAAAGGGG CAGGCGGGAA 251CGGCTCTGGC AACCTATATG CTGATGTTGG AACGCACAAA ATCCCCCGAA 301GTCGCCGAAC GCGCCTTGGA AATGGCCGTG TCGCTGAACG CGTTTGAACA 351GGCGGAAATG ATTTATCAGA AATGGCGGCA GATTGAGCCT ATACCGGGTA 401AGGCGCAAAA ACGGGCGGGG TGGCTGCGGA ACGTGCTGAG GGAAAGAGGA 451AATCAGCATC TAGACGGACT GGAAGAAGTG CTGGCTCAGG CGGACGAAGG 501ACAGAACCGC AGGGTGTTTT TATTGTTGGC ACAAGCCGCC GTGCAACAGG 551ACGGGTTGGC GCAAAAAGCA TCGAAAGCGG TTCGCCGCGC GGCGTTGAGA 601TATGAACATC TGCCCGAAGC GGCGGTTGCC GATGTGGTGT TCAGCGTACA 651GGGACGCGAA AAGGAAAAGG CAATCGGAGC TTTGCAGCGT TTGGCGAAGC 701TCGATACGGA AATATTGCCC CCCACTTTAA TGACGTTGCG TCTGACTGCA 751CGCAAATATC CCGAAATACT CGACGGCTTT TTCGAGCAGA CAGACACCCA 801AAACCTTTCG GCCGTCTGGC AGGAAATGGA AATTATGAAT CTGGTTTCCC 851TGCACAGGCT GGATGATGCC TATGCGCGTT TGAACGTGCT GTTGGAACGC 901AATCCGAATG CAGACCTGTA TATTCAGGCA GCGATATTGG CGGCAAACCG 951AAAAGAAGGT GCTTCCGTTA TCGACGGCTA CGCCGAAAAG GCATACGGCA 1001GGGGGACGGG GGAACAGCGG GGCAGGGCGG CAATGACGGC GGCGATGATA 1051TATGCCGACC GAAGGGATTA CACCAAAGTC AGGCAGTGGT TGAAAAAAGT 1101GTCCGCGCCG GAATACCTGT TCGACAAAGG TGTGCTGGCG GCTGCGGCGG 1151CTGTCGAGTT GGACGGCGGC AGGGCGGCTT TGCGGCAGAT CGGCAGGGTG 1201CGGAAACTTC CCGAACAGCA GGGGCGGTAT TTTACGGCAG ACAATTTGTC 1251CAAAATACAG ATGTTCGCCC TGTCGAAGCT GCCCGACAAA CGGGAGGCTT 1301TGAGGGGGTT GGACAAGATT ATCGAAAAAC CGCCTGCCGG CAGTAATACA 1351GAGTTACAGG CAGAGGCATT GGTACAGCGG TCAGTTGTTT ACGATCGGCT 1401TGGCAAGCGG AAAAAAATGA TTTCAGATCT TGAAAGGGCG TTCAGGCTTG 1451CACCCGATAA CGCTCAGATT ATGAATAATC TGGGCTACAG CCTGCTTTCC 1501GATTCCAAAC GTTTGGACGA AGGCTTCGCC CTGCTTCAGA CGGCATACCA 1551AATCAACCCG GACGATACCG CTGTCAACGA CAGCATAGGC TGGGCGTATT 1601ACCTGAAAGG CGACGCGGAA AGCGCGCTGC CGTATCTGCG GTATTCGTTT 1651GAAAACGACC CCGAGCCCGA AGTTGCCGCC CATTTGGGCG AAGTGTTGTG 1701GGCATTGGGC GAACGCGATC AGGCGGTTGA CGTATGGACG CAGGCGGCAC 1751ACCTTACGGG AGACAAGAAA ATATGGCGGG AAACGCTCAA ACGTCACGGC 1801ATCGCATTGC CCCAACCTTC CCGAAAACCT CGGAAATAAThis corresponds to the amino acid sequence <SEQ ID 2908; ORF 951.a>:

a951.pep 1 MLPARFTILS VLAAALLAGQ AYAAGAADAK PPKEVGKVFR KQQRYSEEEI 51KNERARLAAV GERVNQIFTL LGGETALQKG QAGTALATYM LMLERTKSPE 101VAERALEMAV SLNAFEQAEM IYQKWRQIEP IPGKAQKRAG WLRNVLRERG 151NQHLDGLEEV LAQADEGQNR RVFLLLAQAA VQQDGLAQKA SKAVRRAALR 201YEHLPEAAVA DVVFSVQGRE KEKAIGALQR LAKLDTEILP PTLMTLRLTA 251RKYPEILDGF FEQTDTQNLS AVWQEMEIMN LVSLHRLDDA YARLNVLLER 301NPNADLYIQA AILAANRKEG ASVIDGYAEK AYGRGTGEQR GRAAMTAAMI 351YADRRDYTKV RQWLKKVSAP EYLFDKGVLA AAAAVELDGG RAALRQIGRV 401RKLPEQQGRY FTADNLSKIQ MFALSKLPDK REALRGLDKI IEKPPAGSNT 451ELQAEALVQR SVVYDRLGKR KKMISDLERA FRLAPDNAQI MNNLGYSLLS 501DSKRLDEGFA LLQTAYQINP DDTAVNDSIG WAYYLKGDAE SALPYLRYSF 551ENDPEPEVAA HLGEVLWALG ERDQAVDVWT QAAHLTGDKK IWRETLKRHG 600IALPQPSRKP RK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 951 shows 96.4% identity over a 614 aa overlap with a predicted ORF(ORF 951) from N. meningitidis

a951/m951 96.4% identity in 614 aa overlap        10        20          30        40        50 a951.pep  MLPARFTILSVLAAALLAGQAYAAG--AADAKPPKEVGKVERKQQRYSEEEIKNERAR   ||| ||:|:||:|:|:|||: |||  |:| | ||||||||||||||||||||||||| m951MIMLPNRFKMLTVLTATLIAGQVSAAGGGAGDMKQPKEVGKVERKQQRYSEEEIKNERAR        10        20        30        40        50        60  60        70        80        90       100       110 a951.pepLAAVGERVNQIFTLLGGETALQKGQAGTALATYMLMLERTKSPEVAERALEMAVSLNAFE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m951LAAVGERVNQIFTLLGGETALQKGQAGTALATYMLMLERTKSPEVAERALEMAVSLNAFE        70        80        90       100       110       120 120       130       140       150       160       170 a951.pepQAEMIYQKWRQIEPIPGKAQKRAGWLRNVLRERGNQHLDGLEEVLAQADEGQNRRVFLLL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m951QAEMIYQKWRQIEPIPGKAQKRAGWLRNVLRERGNQHLDGLEEVLAQADEGQNRRVFLLL       130       140       150       160       170       180 180       190       200       210       220       230 a951.pepAQAAVQQDGLAQKASKAVRRAALRYEHLPEAAVADVVFSVQGREKEKAIGALQRLAKLDT|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| m951AQAAVQQDGLAQKASKAVRRAALKYEHLPEAAVADVVFSVQGREKEKAIGALQRLAKLDT       190       200       210       220       230       240 240       250       260       270       280       290 a951.pepEILPPTLMTLRLTARKYPEILDGFFEQTDTQNLSAVWQEMEIMNLVSLHRLDDAYARLNV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m951EILPPTLMTLRLTARKYPEILDGFFEQTDTQNLSAVWQEMEIMNLVSLHRLDDAYARLNV       250       260       270       280       290       300 300       310       320       330       340       350 a951.pepLLERNPNADLYIQAAILAANRKEGASVIDGYAEKAYGRGTGEQRGRAAMTAAMIYADRRD|||||||||||||||||||||||||||||||||||||||| |||:|||:||||:|||||| m951LLERNPNADLYIQAAILAANRKEGASVIDGYAEKAYGRGTEEQRSRAALTAAMMYADRRD       310       320       330       340       350       360 360       370       380       390       400       410 a951.pepYTKVRQWLKKVSAPEYLFDKGVLAAAAAVELDGGRAALRQIGRVRKLPEQQGRYFTADNL|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m951YAKVRQWLKKVSAPEYLFDKGVLAAAAAVELDGGRAALRQIGRVRKLPEQQGRYFTADNL       370       380       390       400       410       420 420       430       440       450       460       470 a951.pepSKIQMFALSKLPDKREALRGLDKIIEKPPAGSNTELQAEALVQRSVVYDRLGKRKKMISD|||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||| m951SKIQMLALSKLPDKREALRGLDKIIEKPPAGSNTELQAEALVQRSVVYDRLGKRKKMISD       430       440       450       460       470       480 480       490       500       510       520       530 a951.pepLERAFRLAPDNAQIMNNLGYSLLSDSKRLDEGFALLQTAYQINPDDTAVNDSIGWAYYLK|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||| m951LERAFRLAPDNAQIMNNLGYSLLTDSKRLDEGFALLQTAYQINPDDTAVNDSIGWAYYLK       490       500       510       520       530       540 540       550       560       570       580       590 a951.pepGDAESALPYLRYSFENDPEPEVAAHLGEVLWALGERDQAVDVWTQAAHLTGDKKIWRELL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m951GDAESALPYLRYSFENDPEPEVAAHLGEVLWALGERDQAVDVWTQAAHLTGDKKIWRELL       550       560       570       580       590       600 600       610 a951.pep KRHGIALPQPSRKPRK |||||||||||||||| m951KRHGIALPQPSRKPRK        610The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2909>:

g952.seq (partial) 1..TTGTCTTATC GTTTGAATGC TGCACCGATG TTTAACGATA ATCCTGTTGT 51  TTACGGAAAA ATCAAATTGC AGAGTTGGAA AGCGCGGCGG GATTTCAATA 101  TTGTAAAGCA GGATTTGGAT TTTTCCTGCG GGGCGGCTTC GGTGGCGACG 151  CTTTTGAACA ATTTTTACGG GCAAAAGCTG ACGGAAGAAG AAGTGTTGGA 201  AAAACTGGGT AAGGAACAGA TGCGCGCGTC GTTTGAGGAT ATGCGGCGCA 251  TTATGCCCGA TTTGGGTTTT GAGGCGAAAG GCTATGCCCT GTCTTTCGAA 301  CAGCTCGCGC AGTTGAAAAT CCCCGTCATC GTGTATCTGA AATACCGCAA 351  AGACGACCAT TTTTCGGTAT TGCGCGGAGT GGATGGCAAT ACGGTTTTGC 401  TTGCCGACCC GTCGCCGGGT CATGTTTCGA TGAGCAGGGC GCAGTTTTTG 451  GAGGCTTGGC AAACCCGTGA GGGAAATTTG GCAGGCAAAA TTTTGGCGGT 501  CGTGCCGAAA AAAGCGGAGG CGATTTCAAA TAAATTGTTT TTCACACATC 551  ATCCCAAGCG GCAGACGGAG TTTGCAGTCG GACAGGTAAA ATGGTGGCGT 601   GCTTATTGAThis corresponds to the amino acid sequence <SEQ ID 2910; ORF 952.ng>:

g952.pep (partial) 1 ..LSYRLNAAPM FNDNPVVYGK IKLQSWKARR DFNIVKQDLDFSCGAASVAT 51   LLNNFYGQKL TEEEVLEKLG KEQMRASFED MRRIMPDLGF EAKGYALSFE101   QLAQLKIPVI VYLKYRKDDH FSVLRGVDGN TVLLADPSPG HVSMSRAQFL 151  EAWQTREGNL AGKILAVVPK KAEAISNKLF FTHHPKRQTE FAVGQVKWWR 201   AY*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2911>:

m952.seq 1 ATGATGAAGT TCAAATATGT TTTTCTGTTG GCGTGTGTTG TCGTTTCTTT 51ATCTTATCGT TTGAATGCTG CACCGATGTT TAACGATAAT CCTGTTGTTT 101 ACGGAAAAATCAAAGTGCAG AGTTGGAAAG CGCGGCGGGA TTTCAATATT 151 GTAAAGCAGG ATTTGGATTTTTCCTGTGGG GCGGCTTCGG TGGCGACGCT 201 TTTGAACAAT TTTTACGGGC AAACGCTGACGGAAGAAGAA GTGTTGAAAA 251 AGCTGGATAA GGAGCAGATG CGCGCGTCGT TTGAGGATATGCGGCGCATT 301 ATGCCTGATT TGGGTTTTGA GGCGAAGGGC TATGCCCTGT CTTTCGAGCA351 GCTCGCGCAG TTGAAAATCC CCGTCATCGT GTATCTGAAA TACCGCAAAG 401ACGACCATTT TTCGGTATTG CGCGGTATAG ACGGCAATAC GGTTTTGCTT 451 GCCGACCCGTCGCTGGGGCA TGTTTCAATG AGCAGGGCGC AGTTTTTGGA 501 TGCTTGGCAA ACCCGTGAGGGAAATTTGGC AGGTAAGATT TTGGCTGTCA 551 TACCGAAAAA AGCCGAGACA ATTTCAAATAAATTGTTTTT CACACAACAC 601 CCAAAACGGC AGACGGAGTT TACAGTCGGA CAAATCAGGCAAGCACGTGC 651 AGAGTAAThis corresponds to the amino acid sequence <SEQ ID 2912; ORF 952>:

m952.pep 1 MMKFKYVFLL ACVVVSLSYR LNAAPMFNDN PVVYGKIKVQ SWKARRDFNI 51VKQDLDFSCG AASVATLLNN FYGQTLTEEE VLKKLDKEQM RASFEDMRRI 101 MPDLGFEAKGYALSFEQLAQ LKIPVIVYLK YRKDDHFSVL RGIDGNTVLL 151 ADPSLGHVSM SRAQFLDAWQTREGNLAGKI LAVIPKKAET ISNKLFFTQH 201 PKRQTEFTVG QIRQARAE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 952 shows 92.5% identity over a 201 aa overlap with a predicted ORF(ORF 952) from N. gonorrhoeae

g952/m952; 92.5% identity in 201 aa overlap                        10        20        30        40 g952.pep                LSYRLNAAPMFNDNPVVYGKIKLQSWKARRDFNIVKQDLDFSCG                ||||||||||||||||||||||:||||||||||||||||||||| m952MMKFKYVFLLACVVVSLSYRLNAAPMFNDNPVVYGKIKVQSWKARRDFNIVKQDLDFSCG        10        20        30        40        50        60    50        60        70        80        90       100 g952.pepAASVATLLNNFYGQKLTEEEVLEKLGKEQMRASFEDMRRIMPDLGFEAKGYALSFEQLAQ|||||||||||||| |||||||:|| ||||||||||||||||||||||||||||||||||| m952AASVATLLNNFYGQTLTEEEVLKKLDKEQMRASFEDMRRIMPDLGFEAKGYALSFEQLAQ        70        80        90       100       110       120   110       120       130       140       150       160 g952.pepLKIPVIVYLKYRKDDHFSVLRGVDGNTVLLADPSPGHVSMSRAQFLEAWQTREGNLAGKI||||||||||||||||||||||:|||||||||||| |||||||||||:||||||||||||| m952LKIPVIVYLKYRKDDHFSVLRGIDGNTVLLADPSLGHVSMSRAQFLDAWQTREGNLAGKI       130       140       150       160       170       180   170       180       190       200 g952.pepLAVVPKKAEAISNKLFFTHHPKRQTEFAVGQVKWWRAYX|||:|||||:||||||||:||||||||:|||::   || m952LAVIPKKAETISNKLFFTQHPKRQTEFTVGQIRQARAE        190       200       210The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2913>:

a952.seq 1 ATGATGAAGT TCAAATATGT TTTTCTGTTG GCGTGTGTTG TCGTTTCTTT 51ATCTTATCGT TTGAATGCTG CACCGATGTT TAACGATAAT CCTGTTGTTT 101 ACGGAAAAATCAAAGTGCAG AGTTGGAAAG AAAGGCGGGA TTTCAATATT 151 GTAAAGCAGG ATTTGGATTTTTCCTGCGGG GCGGCTTCGG TGGCGACGCT 201 TTTGAACAAT TTTTACGGGC AAACGCTGACGGAAGAAGAA GTGTTGAAAA 251 AGCTGGATAA GGAGCAGATG CGCGCGTCGT TTGAGGATATGCGGCGCATT 301 ATGCCAGATT TGGGTTTTGA AGCGAAAGGC TATGCCCTGT CTTTCGAGCA351 GCTCGCACAG TTGAAAATCC CCGTCATCGT GTATCTGAAA TACCGCAAGG 401ATGATCATTT CTCGGTATTG CGCGGGATAG ACGGCAATAC GGTTTTGCTT 451 GCCGACCCGTCGCTGGGTCA TGTTTCAATG AGCAGGGCGC AGTTTTNGGA 501 TGCTTGGCAA ACCCGTGAGGGAAATTTGGC AGGTAAGATT TTGGCGGTCG 551 TGCCGAAAAA AGCCGAGACA ATTTCAAATAAATTGTTTTT CACACATCAT 601 CCCAAGCGGC AGACGGAGTT TGCAGTCGGA CAAATCAGGCAAGCACGTGC 651 AGAGTAAThis corresponds to the amino acid sequence <SEQ ID 2914; ORF 952.a>:

a952.pep 1 MMKFKYVFLL ACVVVSLSYR LNAAPMFNDN PVVYGKIKVQ SWKERRDFNI 51VKQDLDFSCG AASVATLLNN FYGQTLTEEE VLKKLDKEQM RASFEDMRRI 101 MPDLGFEAKGYALSFEQLAQ LKIPVIVYLK YRKDDHFSVL RGIDGNTVLL 151 ADPSLGHVSM SRAQFXDAWQTREGNLAGKI LAVVPKKAET ISNKLFFTHH 201 PKRQTEFAVG QIRQARAE*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 952 shows 97.7% identity over a 218 aa overlap with a predicted ORF(ORF 952) from N. meningitidis

a952/m952 97.7% identity in 218 aa overlap        10        20        30        40        50        60 a952.pepMMKFKYVFLLACVVVSLSYRLNAAPMFNDNPVVYGKIKVQSWKERRDFNIVKQDLDFSCG||||||||||||||||||||||||||||||||||||||||||| |||||||||||||||| m952MMKFKYVFLLACVVVSLSYRLNAAPMFNDNPVVYGKIKVQSWKARRDFNIVKQDLDFSCG        10        20        30        40        50        60        70        80        90       100       110       120 a952.pepAASVATLLNNFYGQTLTEEEVLKKLDKEQMRASFEDMRRIMPDLGFEAKGYALSFEQLAQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m952AASVATLLNNFYGQTLTEEEVLKKLDKEQMRASFEDMRRIMPDLGFEAKGYALSFEQLAQ        70        80        90       100       110       120       130       140       150       160       170       180 a952.pepLKIPVIVYLKYRKDDHFSVLRGIDGNTVLLADPSLGHVSMSRAQFXDAWQTREGNLAGKI||||||||||||||||||||||||||||||||||||||||||||| |||||||||||||| m952LKIPVIVYLKYRKDDHFSVLRGIDGNTVLLADPSLGHVSMSRAQFLDAWQTREGNLAGKI       130       140       150       160       170       180       190       200       210       219 a952.pepLAVVPKKAETISNKLFFTHHPKRQTEFAVGQIRQARAEX|||:||||||||||||||:||||||||:|||||||||| m952LAVIPKKAETISNKLFFTQHPKRQTEFTVGQIRQARAE        190       200       210The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2915>:

g953.seq 1 ATGAAAAAAA TCATCTTCGC CGCGCTCGCA GCGGCAGCCG TCGGCACTGC 51CTCCGCCACC TACAAAGTGG ACGAATATCA CGCCAACGTC CGTTTCGCCA 101 TCGACCACTTCAACACCAGC ACCAACGTCG GCGGTTTTTA CGGTCTGACC 151 GGTTCCGTCG AGTTCGATCAAGCAAAACGC GACGGCAAAA TCGACATCAC 201 CATTCCCGTC GCCAACCTGC AAAGCGGTTCGCAACCCTTC ACCGGCCACC 251 TGAAATCCGC CGACATCTTC GATGCCGCTC AATATCCGGACATCCGCTTC 301 GTTTCCACCA AATTCAACTT CAACGGCAAA AAACTTGTTT CCGTTGACGG351 CAACCTGACC ATGCGCGGCA AAACCGCCCC CGTCAAACTC AAAGCCGAAA 401AATTCAACTG CTACCAAAGC CCGATGGCGG AAACCGAAGT TTGCGGCGGC 451 GACTTCAGCACCACCATCGA CCGCACCAAA TGGGGCGTGG ACTACCTCGT 501 TAACGCCGGT ATGACCAAAAACGTCCGCAT CGACATCCAA ATCGAAGCTG 551 CAAAACAATA AThis corresponds to the amino acid sequence <SEQ ID 2916; ORF 953.ng>:

g953.pep 1 MKKIIFAALA AAAVGTASAT YKVDEYHANV RFAIDHFNTS TNVGGFYGLT 51GSVEFDQAKR DGKIDITIPV ANLQSGSQPF TGHLKSADIF DAAQYPDIRF 101 VSTKFNFNGKKLVSVDGNLT MRGKTAPVKL KAEKFNCYQS PMAETEVCGG 151 DFSTTIDRTK WGVDYLVNAGMTKNVRIDIQ IEAAKQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2917>:

m953.seq 1 ATGAAAAAAA TCATCTTCGC CGCACTCGCA GCCGCCGCCA TCAGTACTGC 51CTCCGCCGCC ACCTACAAAG TGGACGAATA TCACGCCAAC GCCCGTTTCG 101 CCATCGACCATTTCAACACC AGCACCAACG TCGGCGGTTT TTACGGTCTG 151 ACCGGTTCCG TCGAGTTCGACCAAGCAAAA CGCGACGGTA AAATCGACAT 201 CACCATCCCC ATTGCCAACC TGCAAAGCGGTTCGCAACAC TTTACCGACC 251 ACCTGAAATC AGCCGACATC TTCGATGCCG CCCAATATCCGGACATCCGC 301 TTTGTTTCCA CCAAATTCAA CTTCAACGGC AAAAAACTGG TTTCCGTTGA351 CGGCAACCTG ACCATGCACG GCAAAACCGC CCCCGTCAAA CTCAAAGCCG 401AAAAATTCAA CTGCTACCAA AGCCCGATGG AGAAAACCGA AGTTTGTGGC 451 GGCGACTTCAGCACCACCAT CGACCGCACC AAATGGGGCA TGGACTACCT 501 CGTTAACGTT GGTATGACCAAAAGCGTCCG CATCGACATC CAAATCGAGG 551 CAGCCAAACA ATAAThis corresponds to the amino acid sequence <SEQ ID 2918; ORF 953>:

m953.pep 1 MKKIIFAALA AAAISTASAA TYKVDEYHAN ARFAIDHFNT STNVGGFYGL 51TGSVEFDQAK RDGKIDITIP IANLQSGSQH FTDHLKSADI FDAAQYPDIR 101 FVSTKFNFNGKKLVSVDGNL TMHGKTAPVK LKAEKFNCYQ SPMEKTEVCG 151 GDFSTTIDRT KWGMDYLVNVGMTKSVRIDI QIEAAKQ*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 953 shows 93.0% identity over a 187 aa overlap with a predicted ORF(ORF 953) from N. gonorrhoeae

m953/g953 93.0% identity in 187 aa overlap          10        20        30        40        50        60 m953.pep  MKKIIFAALAAAAISTASAATYKVDEYHANARFAIDHFNTSTNVGGFYGLTGSVEFDQAK  |||||||||||||::|||| ||||||||||:||||||||||||||||||||||||||||| g953  MKKIIFAALAAAAVGTASA-TYKVDEYHANVRFAIDHFNTSTNVGGFYGLTGSVEFDQAK          10        20        30        40        50          70        80        90       100       110       120 m953.pep  RDGKIDITIPIANLQSGSQHFTDHLKSADIFDAAQYPDIRFVSTKFNFNGKKLVSVDGNL  ||||||||||:|||||||| || ||||||||||||||||||||||||||||||||||||| g953  RDGKIDITIPVANLQSGSQPFTGHLKSADIFDAAQYPDIRFVSTKFNFNGKKLVSVDGNL 60        70        80        90       100       110         130       140       150       160       170       180 m953.pep  TMHGKTAPVKLKAEKFNCYQSPMEKTEVCGGDFSTTIDRTKWGMDYLVNVGMTKSVRIDI  ||:|||||||||||||||||||| :||||||||||||||||||:|||||:||||:||||| g953  TMRGKTAPVKLKAEKFNCYQSPMAETEVCGGDFSTTIDRTKWGVDYLVNAGMTKNVRIDI120       130       140       150       160       170 m953.pep  QIEAAKQX   |||||||| g953   QIEAAKQX 180The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2919>:

a953.seq 1 ATGAAAAAAA TCATCATCGC CGCGCTCGCA GCAGCCGCCA TCGGCACTGC 51CTCCGCCGCC ACCTACAAAG TGGACGAATA TCACGCCAAC GCCCGTTTCT 101 CTATCGACCATTTCAACACC AGCACCAACG TCGGCGGTTT TTACGGTCTG 151 ACCGGTTCCG TTGAGTTCGACCAAGCAAAA CGCGACGGTA AAATCGACAT 201 CACCATCCCC GTTGCCAACC TGCAAAGCGGTTCGCAACAC TTTACCGACC 251 ACCTGAAATC AGCCGACATC TTCGATGCCG CCCAATATCCGGACATCCGC 301 TTTGTTTCCA CCAAATTCAA CTTCAACGGC AAAAAACTGG TTTCCGTTGA351 CGGCAACCTG ACCATGCACG GCAAAACCGC CCCCGTCAAA CTCAAAGCCG 401AAAAATTCAA CTGCTACCAA AGCCCGATGT TGAAAACCGA AGTTTGCGGC 451 GGCGACTTCAGCACCACCAT CGACCGCACC AAATGGGGCA TGGACTACCT 501 CGTTAACGTT GGTATGACCAAAAGCGTCCG CATCGACATC CAAATCGAGG 551 CAGCCAAACA ATAAThis corresponds to the amino acid sequence <SEQ ID 2920; ORF 953.a>:

a953.pep 1 MKKIIIAALA AAAIGTASAA TYKVDEYHAN ARFSIDHFNT STNVGGFYGL 51TGSVEFDQAK RDGKIDITIP VANLQSGSQH FTDHLKSADI FDAAQYPDIR 101 FVSTKFNFNGKKLVSVDGNL TMHGKTAPVK LKAEKFNCYQ SPMLKTEVCG 151 GDFSTTIDRT KWGMDYLVNVGMTKSVRIDI QIEAAKQ*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 953 shows 97.3% identity over a 187 aa overlap with a predicted ORF(ORF 953) from N. meningitidis

a953/m953 97.3% identity in 187 aa overlap        10        20        30        40        50        60 a953.pepMKKIIIAALAAAAIGTASAATYKVDEYHANARFSIDHFNTSTNVGGFYGLTGSVEFDQAK|||||:||||||||:||||||||||||||||||:|||||||||||||||||||||||||| m953MKKIIFAALAAAAISTASAATYKVDEYHANARFAIDHFNTSTNVGGFYGLTGSVEFDQAK        10        20        30        40        50        60        70        80        90       100       110       120 a953.pepRDGKIDITIPVANLQSGSQHFTDHLKSADIFDAAQYPDIRFVSTKFNFNGKKLVSVDGNL||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||| m953RDGKIDITIPIANLQSGSQHFTDHLKSADI FDAAQYPDIRFVSTKFNFNGKKLVSVDGNL        70        80        90       100       110       120       130       140       150       160       170       180 a953.pepTMHGKTAPVKLKAEKFNCYQSPMLKTEVCGGDFSTTIDRTKWGMDYLVNVGMTKSVRIDI||||||||||||||||||||||| |||||||||||||||||||||||||||||||||||| m953TMHGKTAPVKLKAEKFNCYQSPMEKTEVCGGDFSTTIDRTKWGMDYLVNVGMTKSVRIDI       130       140       150       160       170       180 a953.pepQIEAAKQX |||||||| m953 QIEAAKQX

g954.seq not found yet

g954.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2921>:

m954.seq 1 ATGAAAAAGT TTTATTTTGT GCTGCTGGCG TTGGGTTTGG CAGCGTGTGG 51GCAAGAACAA TCGCAGAAAG CTGATGCGGA GCAGTATTTT TTTGCCAATA 101 AATATCAATTTGCAGATGAG AAACAGGCTT TTTATTTTGA ACGCGCCGCC 151 CGTTTCCGTG TATTGCAACAAGGCCTTGGC GGGGATTTTG AGAGGTTTTT 201 AAAAGGAGAA ATACCTAATC AAGAAAATCTTGCAAAGTAT CGTGAAAATA 251 TTACTCAAGC AGTCGCTTAT TATGCGGACA CGAATGGAGATGATGACCCA 301 TACCGCGTCT GCAAACAGGC TGCGCAAGAT GCAGAAATCC TGATGAAGAG351 TATGGTAACA AGCGGTGGAG GCGGTACAAC TGATTTAGAT AAGGAAAGTT 401ATCAAAATTA CCGAAAATCA ATGCAAGAAT GCCGTAAAAC AATAACGGAA 451 GCTGAAGCCAATTTGCCGAA AAAATAAThis corresponds to the amino acid sequence <SEQ ID 2922; ORF 954>:

m954.pep 1 MKKFYFVLLA LGLAACGQEQ SQKADAEQYF FANKYQFADE KQAFYFERAA 51RFRVLQQGLG GDFERFLKGE IPNQENLAKY RENITQAVAY YADTNGDDDP 101 YRVCKQAAQDAEILMKSMVT SGGGGTTDLD KESYQNYRKS MQECRKTITE 151 AEANLPKK*

a954.seq not found yet

a954.pep not found yet

The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2923>:

g957.seq (partial) 1 ATGTTTAAAA AATTCAAACC GGTACTGTTG TCATTTTTTGCACTTGTATT 51 TGCCTTTTGG CTGGGAACAG GTATTGCCTA TGAGATTAAT CCGCGTTGGT 101TTTTGAGCGA TACGGCAACT GAAGTACCTG AAAATCCGAA TGCTTTTGTG 151 GCGAAACTTGCCCGCCTGTT CCGAAATGCC GACAGGGCGG TTGTCATCGT 201 GAAGGAATCG ATGAGGACGGAGGAAAGCCT TGCCGGAGCT GTGGATGACG 251 GTCCGTTGCA GTCGGAGAAG GATTATCTCGCGCTCGCTAT CCGGCTCAGT 301 CGTTTGAAAG AAAAGGCGAA ATGGTTTCAC GTAACGGAGCAGGAACATGG 351 GGAAGAGGTT TGGCTGGATT ACTATATCGG CGAGGGCGGT TTGGTTGCGG401 TTTCGCTTTC GCAACGCTCG CCGGAAGCGT TTGTTAATGC CGAATATCTG 451TATCGGAACG ATCGTCCGTT TTCTGTAAAT GTGTACGGCG GAACGGCTCA 501 CGGGGAAAATTATGAAACGA CAGGAGAATA TCGGGTTGTT TGGCAACCGG 551 ACGGTTCGGT ATTTGATGCGGCGGGGCGCG GGAAAATCGG GGAAGATGTT 601 TATGAGCATT GCCTCGGGTG TTATCAGATGGCCCAGGTAT ATTTGGCGAA 651 ATACCGGGAT GTCGCGAATG ACGAGCAGAA GGTTTGGGACTTCCGCGAAG 701 AGAGCAACCG GATTGCATCG GACTCGCGCG ATTATGTGTT TTATCAGAAT751 ATGCGGGAAT TGATGCCCCG GGGGatgaaG gcgaacagtc ttgtggtcgg 801ctatgatgcg gacggtCtgc CgcaAAAagt ctattggagt gtcgacaatg 851 gaaaaaaaccccaaagtgtc gaatattatt tgaaaaacgg aaatcttttt 901 attgcccaat cttcgacggtaaccttgaaa acggatggcg taacggcgga 951 tatgcaaacc tatcatgcgc aacaaacgttgtatttggat ggg...This corresponds to the amino acid sequence <SEQ ID 2924; ORF 957.ng>:

g957.pep (partial) 1 MFKKFKPVLL SFFALVFAFW LGTGIAYEIN PRWFLSDTATEVPENPNAFV 51 AKLARLFRNA DRAVVIVKES MRTEESLAGA VDDGPLQSEK DYLALAIRLS 101RLKEKAKWFH VTEQEHGEEV WLDYYIGEGG LVAVSLSQRS PEAFVNAEYL 151 YRNDRPFSVNVYGGTAHGEN YETTGEYRVV WQPDGSVFDA AGRGKIGEDV 201 YEHCLGCYQM AQVYLAKYRDVANDEQKVWD FREESNRIAS DSRDYVFYQN 251 MRELMPRGMK ANSLVVGYDA DGLPQKVYWSVDNGKKPQSV EYYLKNGNLF 301 IAQSSTVTLK TDGVTADMQT YHAQQTLYLD G...The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2925>:

m957.seq 1 ATGTTTAAAA AATTCAAACC GGTACTGTTG TCATTTTTTG CACTTGTATT 51TGCCTTTTGG CTGGGAACGG GTATTGCCTA TGAGATTAAT CCGCGTTGGT 101 TTTTGAGCGATACGGCAACT GAAGTACCTA AAAATCCGAA TGCTTTTGTG 151 GCGAAACTTG CCCGCCTGTTCCGAAATGCC GACAGGGCGG TTGTCATCGT 201 GAAGGAATCG ATAAGGACGG AGGAAAATCTTGCCGGAACT GTGGATGACG 251 GTCCGTTGCA GTCGGAGAAG GATTATCTCG CGCTCGCTATCCGGCTCAGT 301 CGTTTGAAAG AAAAGGCGAA ATGGTTTCAC GTAACGGAGC AGGAACATGG351 GAAAGAGGTT TGGCTGGATT ACCATATCGG CGAGGGCGGT TTGGTTGCGG 401TTTCGCTTTC GCAACGCTCG CCGGAAGCAT TTGTTAATGC CGAATATCTG 451 TATCGGAACGATCGTCCGTT TTCTGTAAAT GTGTACGGCG GAACGGTTCA 501 CGGGGAAAAT TATGAAACGACAGGAGAATA TCGGGTTGTT TGGCAACCAG 551 ACGGTTCGGT ATTTGATGCG GCGGGGCGCGGGAAAATCGG GGAAGATGTT 601 TATGAGCATT GCCTCGGGTG TTATCAGATG GCCCAGGTATATTTGGCGAA 651 ATACCGGGAT GTCGCGAATG ACGAGCAGAA GGTTTGGGAC TTCCGCAAAG701 AGAGCAACCG AATTGCGTCG GACTCGCGCA ATTCTGTGTT TTATCAGAAT 751ATGCGGGAAT TGATGCCCCG AGGGATGAAG GCGAACAGTC TTGTGGTCGG 801 CTATGATGCGGACGGTCTGC CGCAAAAAGT CTATTGGAGT TTCGACAATG 851 GAAAAAAACG CCAGAGTTTCGAATATTATT TGAAAAACGG AAATCTTTTT 901 ATTGCACAAT CTTCGACGGT AGCATTGAAAGCGGATGGCG TAACGGCGGA 951 TATGCAGACC TATCATGCGC AACAGACGTG GTATTTGGATGGCGGGCGGA 1001 TTGTCCGCGA AGAGAAACAG GGAGACAGAC TGCCTGATTT TCCTTTGAAC1051 TTGGAAAATT TGGAAAAAGA GGTGCGCCGT TATGCAGAGG CTGCGGCGAG 1101ACGTTCGGGC GGCAGGCGCG ACCTTTCTCA CTGAThis corresponds to the amino acid sequence <SEQ ID 2926; ORF 957>:

m957.pep 1 MFKKFKPVLL SFFALVFAFW LGTGIAYEIN PRWFLSDTAT EVPKNPNAFV 51AKLARLFRNA DRAVVIVKES IRTEENLAGT VDDGPLQSEK DYLALAIRLS 101 RLKEKAKWFHVTEQEHGKEV WLDYHIGEGG LVAVSLSQRS PEAFVNAEYL 151 YRNDRPFSVN VYGGTVHGENYETTGEYRVV WQPDGSVFDA AGRGKIGEDV 201 YEHCLGCYQM AQVYLAKYRD VANDEQKVWDFRKESNRIAS DSRNSVFYQN 251 MRELMPRGMK ANSLVVGYDA DGLPQKVYWS FDNGKKRQSFEYYLKNGNLF 301 IAQSSTVALK ADGVTADMQT YHAQQTWYLD GGRIVREEKQ GDRLPDFPLN351 LENLEKEVRR YAEAAARRSG GRRDLSH*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 957 shows 95.2% identity over a 331 aa overlap with a predicted ORF(ORF 957) from N. gonorrhoeae

g957/m957 95.2% identity in 331 aa overlap        10        20        30        40        50        60 g957.pepMFKKFKPVLLSFFALVFAFWLGTGIAYEINPRWFLSDTATEVPENPNAFVAKLARLFRNA|||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||| m957MFKKFKPVLLSFFALVFAFWLGTGIAYEINPRWFLSDTATEVPKNPNAFVAKLARLFRNA        10        20        30        40        50        60        70        80        90       100       110       120 g957.pepDRAVVIVKESMRTEESLAGAVDDGPLQSEKDYLALAIRLSRLKEKAKWFHVTEQEHGEEV||||||||||:||||:|||:|||||||||||||||||||||||||||||||||||||:|| m957DRAVVIVKESIRTEENLAGTVDDGPLQSEKDYLALAIRLSRLKEKAKWFHVTEQEHGKEV        70        80        90       100       110       120       130       140       150       160       170       180 g957.pepWLDYYIGEGGLVAVSLSQRSPEAFVNAEYLYRNDRPFSVNVYGGTAHGENYETTGEYRVV||||:||||||||||||||||||||||||||||||||||||||||:|||||||||||||| m957WLDYHIGEGGLVAVSLSQRSPEAFVNAEYLYRNDRPFSVNVYGGTVHGENYETTGEYRVV       130       140       150       160       170       180       190       200       210       220       230       240 g957.pepWQPDGSVFDAAGRGKIGEDVYEHCLGCYQMAQVYLAKYRDVANDEQKVWDFREESNRIAS||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||| m957WQPDGSVFDAAGRGKIGEDVYEHCLGCYQMAQVYLAKYRDVANDEQKVWDFRKESNRIAS       190       200       210       220       230       240       250       260       270       280       290       300 g957.pepDSRDYVFYQNMRELMPRGMKANSLVVGYDADGLPQKVYWSVDNGKKPQSVEYYLKNGNLF |||:||||||||||||||||||||||||||||||||||| ||||| || |||||||||| m957DSRNSVFYQNMRELMPRGMKANSLVVGYDADGLPQKVYWSFDNGKKRQSFEYYLKNGNLF       250       260       270       280       290       300       310       320       330 g957.pep IAQSSTVTLKTDGVTADMQTYHAQQTLYLDG|||||||:||:||||||||||||||| |||| m957IAQSSTVALKADGVTADMQTYHAQQTWYLDGGRIVREEKQGDRLPDFPLNLENLEKEVRR       310       320       330       340       350       360 m957YAEAAARRSGGRRDLSHX        370The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2927>:

a957.seq 1 ATGTTTAAAA AATTCAAACC GGTACTGTTG TCATTTTTTG CACTTGTATT 51TGCCTTTTGG CTGGGAACGG GTATTGCCTA TGAGATTAAT CCGCGTTGGT 101 TTTTGAGCGATACGGCAACT GAAAATCCGA ATGCTTTTGT GGCGAAACTT 151 GCCCGCCTGT TCCGAAATGCCGACAGGGCG GTTGTCATCG TGAAGGAATC 201 GATGAGGACG GAGGAAAGTC TTGCCGGAGCTGTGGATGAC GGTCCGTTGC 251 AGTCGGAGAA GGATTATCTT GCACTCGCTG TCCGGCTCAGTCGTTTGAAA 301 GAAAAGGCGA AATGGTTTCA CGTAACGGAG CAGGAACATG GGGAAGAGGT351 TTGGCTGGAT TACTATATCG GCGAGGGCGG TTTGGTTGCG GTTTCGCTTT 401CGCAACGCTC GCCGGAAGCG TTTGTTAATG CCGAATATCT GTATCGGAAC 451 GATCGTCCGTTTTCTGTAAA TGTGTACGGC GGAACGGTTC ACGGGGAAAA 501 TTATGAAACG ACAGGAGAATATCGGGTTGT TTGGCAACCG GACGGTTCGG 551 TATTTGATGC GTCGGGGCGC GGGAAAATCGGGGAAGATGT TTATGAGCAT 601 TGCCTCGGGT GTTATCAGAT GGCCCAGGTA TATTTGGCGAAATATCGGGA 651 TGTCGCGAAT GATGAGCAGA AGGTTTGGGA CTTCCGCGAA GAGAGTAACC701 GGATTGCGTC GGACTCGCGC GATTCTGTGT TTTATCAGAA TATGCGGGAA 751TTGATGCCCC GAGGGATGAA GGCAAACAGT CTTGTGGTCG GCTATGATGC 801 GGACGGTCTGCCGCAGAAAG TCTATTGGAG TTTCGACAAT GGGAAAAAAC 851 GCCAGAGTTT CGAATATTATTTGAAAAACG GAAATCTTTT TATTGCACAA 901 TCTTCGACGG TAGCATTGAA AGCGGATGGCGTAACGGCGG ATATGCAGAC 951 CTATCATGCG CAACAGACGT GGTATTTAGA TGGCGGGCGGATTGTCCGCG 1001 AAGAGAAACA GGGGGACAGA CTGCCTGATT TTCCTTTGAA CTTGGAAGAT1051 TTGGAAAAAG AGGTGAGCCG TTATGCAGAG GCTGCGGCGA GACGTTCGGG 1101CGGCAGGCGC GACCTTTCTC ACTGAThis corresponds to the amino acid sequence <SEQ ID 2928; ORF 957.a>:

a957.pep 1 MFKKFKPVLL SFFALVFAFW LGTGIAYEIN PRWFLSDTAT ENPNAFVAKL 51ARLFRNADRA VVIVKESMRT EESLAGAVDD GPLQSEKDYL ALAVRLSRLK 101 EKAKWFHVTEQEHGEEVWLD YYIGEGGLVA VSLSQRSPEA FVNAEYLYRN 151 DRPFSVNVYG GTVHGENYETTGEYRVVWQP DGSVFDASGR GKIGEDVYEH 201 CLGCYQMAQV YLAKYRDVAN DEQKVWDFREESNRIASDSR DSVFYQNMRE 251 LMPRGMKANS LVVGYDADGL PQKVYWSFDN GKKRQSFEYYLKNGNLFIAQ 301 SSTVALKADG VTADMQTYHA QQTWYLDGGR IVREEKQGDR LPDFPLNLED351 LEKEVSRYAE AAARRSGGRR DLSH*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 957 shows 96.3% identity over a 377 aa overlap with a predicted ORF(ORF 957) from N. meningitidis

a957/m957 96.3% identity in 377 aa overlap        10        20        30        40           50 a957.pepMFKKFKPVLLSFFALVFAFWLGTGIAYEINPRWFLSDTATE---NPNAFVAKLARLFRNA|||||||||||||||||||||||||||||||||||||||||   |||||||||||||||| m957MFKKFKPVLLSFFALVFAFWLGTGIAYEINPRWFLSDTATEVPKNPNAFVAKLARLFRNA        10        20        30        40        50        60 60        70        80        90       100       110 a957.pepDRAVVIVKESMRTEESLAGAVDDGPLQSEKDYLALAVRLSRLKEKAKWFHVTEQEHGEEV||||||||||:||||:|||:||||||||||||||||:||||||||||||||||||||:|| m957DRAVVIVKESIRTEENLAGTVDDGPLQSEKDYLALAIRLSRLKEKAKWFHVTEQEHGKEV        70        80        90       100       110       120120       130       140       150       160       170 a957.pepWLDYYIGEGGLVAVSLSQRSPEAFVNAEYLYRNDRPFSVNVYGGTVHGENYETTGEYRVV||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||| m957WLDYHIGEGGLVAVSLSQRSPEAFVNAEYLYRNDRPFSVNVYGGTVHGENYETTGEYRVV       130       140       150       160       170       180180       190       200       210       220       230 a957.pepWQPDGSVFDASGRGKIGEDVYEHCLGCYQMAQVYLAKYRDVANDEQKVWDFREESNRIAS||||||||||:|||||||||||||||||||||||||||||||||||||||||:||||||| m957WQPDGSVFDAAGRGKIGEDVYEHCLGCYQMAQVYLAKYRDVANDEQKVWDFRKESNRIAS       190       200       210       220       230       240240       250       260       270       280       290 a957.pepDSRDSVFYQNMRELMPRGMKANSLVVGYDADGLPQKVYWSFDNGKKRQSFEYYLKNGNLF|||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||| m957DSRNSVFYQNMRELMPRGMKANSLVVGYDADGLPQKVYWSFDNGKKRQSFEYYLKNGNLF       250       260       270       280       290       300300       310       320       330       340       350 a957.pepIAQSSTVALKADGVTADMQTYHAQQTWYLDGGRIVREEKQGDRLPDFPLNLEDLEKEVSR||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| | m957IAQSSTVALKADGVTADMQTYHAQQTWYLDGGRIVREEKQGDRLPDFPLNLENLEKEVRR       310       320       330       340       350       360360       370 a957.pep YAEAAARRSGGRRDLSHX |||||||||||||||||| m957YAEAAARRSGGRRDLSHX        370The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2929>:

g958.seq 1 TTGGCTCGTT TATTTTCACT CAAACCACTG GTGCTGGCAT TGGGCTTCTG 51TTTCGGCACG CATTGCGCCG CCGATACCGT TGCGGCGGAA GAGGCGGACG 101 GGCGTGTCGCAGAAGGCGGT GCGCAGGGCG CGTCCGAATC CGCACAAGCT 151 TCCGATTTGA CCCTCGGTTCGACCTGCCTG TTTTGCAGTA ACGAAAGCGG 201 CAGCCCCGAG AGAACCGAAG CCGCCGTCCAAGGCAGCGGC GAAGCATCCG 251 TCCCCGAAGA CTATACGCGC ATTGTTGCCG ACAGGATGGAAGGACAGTCG 301 AAGGTTAAGG TGCGCGCGGA AGGAAGCGTT ATCATCGAAC GGGACGGCGC351 AGTCCTCAAT ACCGATTGGG CGGATTACGA CCAGTCGGGC GACACCGTTA 401CCGTAGGCGA CCGGTTCGCC CTCCAACAGG ACGGTACGCT GATTCGGGGC 451 GAAACCCTGACCTACAATCT CGATCAGCAG ACCGGCGAAG CGCACAACGT 501 CCGTATGGAA ACCGAACAAGGCGGACGGCG GCTGCAAAGC GTCAGCCGCA 551 CCGCCGAAAT GTTGGGCGAA GGGCGTTACAAACTGACGGA AACCCAATTC 601 AACACCTGTT CCGCCGGAGA TGCCGGCTGG TATGTCAAGGCCGCCTCTGT 651 CGAAGCCGAT CGGGGAAAAG GCATAGGCGT TGCCAAACAC GCCGCCTTCG701 TGTTCGGCGG CGTTCCCCTT TTCTATACGC CTTGGGCGGA CTTCCCGCTT 751GACGGCAACC GCAAAAGCGG ACTGCTCGTC CCGTCCGTAT CTGCCGGTTC 801 GGACGGCGTTTCCCTTTCCG TCCCCTATTA TTTCAACCTT GCCCCCAACT 851 TCGATGCCAC TTTCGCCCCCGGCATTATCG GCGAACGCGG CGCGACGTTT 901 GACGGACAAA TCCGTTACCT GCGTCCCGATTACAGCGGAC AGACCGACCT 951 GACCTGGTTG CCGCACGATA AGAAAAGCGG CAGGAACAACCGCTATCAGG 1001 CAAAATGGCA GCACCGGCAC GACATTTCCG ACACGCTTCA GGCGGGTGTC1051 GATTTCAACC AAGTCTCCGA CAGCGGCTAC TACCGCGACT TTTACGGCGG 1101CGAAGAAATC GCCGGCAACG TCAACCTCAA CCGCCGCGTA TGGCTGGATT 1151 ATGGCGGCAGGGCGGCGGGA GGCAGCCTGA ATGCCGGCCT TTCGGTTCAG 1201 AAATACCAGA CGCTGGCAAACCAAAGCGGC TACAAAGACG AACCTTACGC 1251 CATCATGCCC CGCCTTTCTG CCGATTGGCATAAAAACGCA GGCAGGGCGC 1301 AAATCGGCGT GTCCGCACAA TTTACCCGCT TCAGCCACGACGGCCGCCAA 1351 GACGGCAGCC GACTGGTCGT GTATCCCGGT ATCAAATGGG ATTTCAGCAA1401 CAGCTGGGGC TACGTCCGCC CCAAACTCGG GCTGCACGCC ACTTATTACA 1451GCCTCGACAG TTTCGGCGGC AAAGCATCCC GCAGCGTCGG GCGCGTTTTG 1501 CCCGTTGTCAATATCGACGG CGGCACAACC TTCGAACGCA ATACGCGCCT 1551 GTTCGGCGGC GGAGTCGTGCAAACCATCGA GCCGCGCCTG TTCTACAACT 1601 ATATTCCTGC CAAATCTCAA AACGACCTGCCCAATTTCGA TTCGTCGGAA 1651 AGCAGCTTCG GCTACGGGCA GCTTTTCCGC GAAAACCTCTATTACGGCAA 1701 CGACCGCATC AACGCCGCCA ACAGCCTTTC CACCGCCGTG CAGAGCCGTA1751 TTTTGGACGG CGCGACGGGG GAGGAGCGTT TCCGCGCCGG TATCGGTCAG 1801AAATTCTATT TCAAGGATGA TGCGGTGATG CTTGACGGCA GCGTCGGCAA 1851 AAATCCGCGCAGCCGTTCCG ACTGGGTGGC ATTCGCCTCC GGCGGCATAG 1901 GCGGGCGTTT CACCCTCGACAGCAGCATCC ACTACAACCA AAACGACAAA 1951 CGCGCCGAAC ATTACGCCGT CGGCGCAGGCTACCGCCCCG CCCCCGGAAA 2001 AGTGTTGAAC GCCCGCTACA AATACGGGCG CAACGAAAAAATCTACCTGC 2051 AGGCGGACGG TTCCTATTTT TACGACAAAC TCAGCCAGCT CGACCTGTCC2101 GCACAATGGC CGCTGACGCG CAACCTGTCT GCCGTCGTCC GCTACAACTA 2151CGGTTTTGAA GCCAAAAAAC CGATAGAAAT GCTTGCCGGT GCAGAATACA 2201 AAAGCAGTTGCGGCTGCTGG GGCGCGGGCG TGTACGCCCA ACGCTACGTT 2251 ACCGGCGAAA ACACCTACAAAAACGCCGTC TTTTTTTCAC TTCAGTTGAA 2301 AGACCTCAGC AGCGTCGGCA GAAACCCCGCAGGCAGGATG GATGTCGCCG 2351 TTCCCGGCTA CATCCCCGCC CACTCTCTTT CCGCCGGACGCAACAAACGG 2401 CCCTGAThis corresponds to the amino acid sequence <SEQ ID 2930; ORF 958.ng>:

g958.pep 1 LARLFSLKPL VLALGFCFGT HCAADTVAAE EADGRVAEGG AQGASESAQA 51SDLTLGSTCL FCSNESGSPE RTEAAVQGSG EASVPEDYTR IVADRMEGQS 101 KVKVRAEGSVIIERDGAVLN TDWADYDQSG DTVTVGDRFA LQQDGTLIRG 151 ETLTYNLDQQ TGEAHNVRMETEQGGRRLQS VSRTAEMLGE GRYKLTETQF 201 NTCSAGDAGW YVKAASVEAD RGKGIGVAKHAAFVFGGVPL FYTPWADFPL 251 DGNRKSGLLV PSVSAGSDGV SLSVPYYFNL APNFDATFAPGIIGERGATF 301 DGQIRYLRPD YSGQTDLTWL PHDKKSGRNN RYQAKWQHRH DISDTLQAGV351 DFNQVSDSGY YRDFYGGEEI AGNVNLNRRV WLDYGGRAAG GSLNAGLSVQ 401KYQTLANQSG YKDEPYAIMP RLSADWHKNA GRAQIGVSAQ FTRFSHDGRQ 451 DGSRLVVYPGIKWDFSNSWG YVRPKLGLHA TYYSLDSFGG KASRSVGRVL 501 PVVNIDGGTT FERNTRLFGGGVVQTIEPRL FYNYIPAKSQ NDLPNFDSSE 551 SSFGYGQLFR ENLYYGNDRI NAANSLSTAVQSRILDGATG EERFRAGIGQ 601 KFYFKDDAVM LDGSVGKNPR SRSDWVAFAS GGIGGRFTLDSSIHYNQNDK 651 RAEHYAVGAG YRPAPGKVLN ARYKYGRNEK IYLQADGSYF YDKLSQLDLS701 AQWPLTRNLS AVVRYNYGFE AKKPIEMLAG AEYKSSCGCW GAGVYAQRYV 751TGENTYKNAV FFSLQLKDLS SVGRNPAGRM DVAVPGYIPA HSLSAGRNKR 801 P*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2931>:

m958.seq 1 TTGGCTCGTT TATTTTCACT CAAACCACTG GTGCTGGCAT TGGGCCTCTG 51CTTCGGCACG CATTGCGCCG CCGCCGATGC CGTTGCGGCG GAGGAAACGG 101 ACAATCCGACCGCCGGAGAA AGCGTTCGGA GCGTGTCCGA ACCCATACAG 151 CCTACCAGCC TGAGCCTCGGTTCGACCTGC CTGTTTTGCA GTAACGAAAG 201 CGGCAGCCCC GAGAGAACCG AAGCCGCCGTCCAAGGCAGC GGCGAAGCAT 251 CCATCCCCGA AGACTATACG CGCATTGTTG CCGACAGGATGGAAGGACAG 301 TCGCAGGTGC AGGTGCGTGC CGAAGGCAAC GTCGTCGTCG AACGCAACCG351 GACGACCCTC AATACCGATT GGGCGGATTA CGACCAGTCG GGCGACACCG 401TTACCGCAGG CGACCGGTTC GCCCTCCAAC AGGACGGTAC GCTGATTCGG 451 GGCGAAACCCTGACCTACAA TCTCGAGCAG CAGACCGGGG AAGCGCACAA 501 CGTCCGCATG GAAATCGAACAAGGCGGACG GCGGCTGCAA AGCGTCAGCC 551 GCACCGCCGA AATGTTGGGC GAAGGGCATTACAAACTGAC GGAAACCCAA 601 TTCAACACCT GTTCCGCCGG CGATGCCGGC TGGTATGTCAAGGCAGCCTC 651 TGTCGAAGCC GATCGGGAAA AAGGCATAGG CGTTGCCAAA CACGCCGCCT701 TCGTGTTCGG CGGCGTTCCC ATTTTCTACA CCCCTTGGGC GGACTTCCCG 751CTTGACGGCA ACCGCAAAAG CGGCCTGCTT GTTCCCTCAC TGTCCGCCGG 801 TTCGGACGGCGTTTCCCTTT CCGTTCCCTA TTATTTCAAC CTTGCCCCCA 851 ATCTCGATGC CACGTTCGCGCCCAGCGTGA TCGGCGAACG CGGCGCGGTC 901 TTTGACGGGC AGGTACGCTA CCTGCGGCCGGATTATGCCG GCCAGTCCGA 951 CCTGACCTGG CTGCCGCACG ACAAGAAAAG CGGCAGGAATAACCGCTATC 1001 AGGCGAAATG GCAGCATCGG CACGACATTT CCGACACGCT TCAGGCGGGT1051 GTCGATTTCA ACCAAGTCTC CGACAGCGGC TACTACCGCG ACTTTTACGG 1101CAACAAAGAA ATCGCCGGCA ACGTCAACCT CAACCGCCGT GTATGGCTGG 1151 ATTATGGCGGCAGGGCGGCG GGCGGCAGCC TGAATGCCGG CCTTTCGGTT 1201 CTGAAATACC AGACGCTGGCAAACCAAAGC GGCTACAAAG ACAAACCGTA 1251 TGCCCTCATG CCGCGCCTTT CGGTCGAGTGGCGTAAAAAC ACCGGCAGGG 1301 CGCAAATCGG CGTGTCCGCA CAATTTACCC GATTCAGCCACGACAGCCGC 1351 CAAGACGGCA GCCGCCTGGT CGTCTATCCC GACATCAAAT GGGATTTCAG1401 CAACAGCTGG GGCTATGTCC GTCCCAAACT CGGACTGCAC GCCACCTATT 1451ACAGCCTCAA CCGCTTCGGC AGCCAAGAAG CCCGACGCGT CAGCCGCACT 1501 CTGCCCATTGTCAACATCGA CAGCGGCGCA ACTTTTGAGC GGAATACGCG 1551 GATGTTCGGC GGAGAAGTCCTGCAAACCCT CGAGCCGCGC CTGTTCTACA 1601 ACTATATTCC TGCCAAATCC CAAAACGACCTGCCCAATTT CGATTCGTCG 1651 GAAAGCAGCT TCGGCTACGG GCAGCTCTTT CGCGAAAACCTCTATTACGG 1701 CAACGACAGG ATTAACACCG CAAACAGCCT TTCCGCCGCC GTGCAAAGCC1751 GTATTTTGGA CGGCGCGACG GGGGAAGAGC GTTTCCGCGC CGGCATCGGT 1801CAGAAATTCT ATTTCAAGGA TGATGCGGTG ATGCTTGACG GCAGCGTCGG 1851 CAAAAAACCGCGCAACCGTT CCGACTGGGT GGCATTTGCC TCCGGCAGCA 1901 TCGGCAGCCG CTTCATCCTCGACAGCAGCA TCCACTACAA CCAAAACGAC 1951 AAACGCGCCG AGAACTACGC CGTCGGTGCAAGCTACCGTC CCGCACAGGG 2001 CAAAGTGCTG AACGCCCGCT ACAAATACGG GCGCAACGAAAAAATCTACC 2051 TGAAGTCCGA CGGTTCCTAT TTTTACGACA AACTCAGCCA GCTCGACCTG2101 TCCGCACAAT GGCCGCTGAC GCGCAACCTG TCGGCCGTCG TCCGTTACAA 2151CTACGGTTTT GAAGCCAAAA AACCGATAGA GGTGCTGGCG GGTGCGGAAT 2201 ACAAAAGCAGTTGCGGCTGC TGGGGCGCGG GCGTGTACGC CCAACGCTAC 2251 GTTACCGGCG AAAACACCTACAAAAACGCT GTCTTTTTCT CACTTCAGTT 2301 GAAAGACCTC AGCAGTGTCG GCAGAAACCCCGCAGACAGG ATGGATGTCG 2351 CCGTTCCCGG CTATATCACC GCCCACTCTC TTTCCGCCGGACGCAACAAA 2401 CGACCCTGAThis corresponds to the amino acid sequence <SEQ ID 2932; ORF 958>:

m958.pep 1 LARLFSLKPL VLALGLCFGT HCAAADAVAA EETDNPTAGE SVRSVSEPIQ 51PTSLSLGSTC LFCSNESGSP ERTEAAVQGS GEASIPEDYT RIVADRMEGQ 101 SQVQVRAEGNVVVERNRTTL NTDWADYDQS GDTVTAGDRF ALQQDGTLIR 151 GETLTYNLEQ QTGEAHNVRMEIEQGGRRLQ SVSRTAEMLG EGHYKLTETQ 201 FNTCSAGDAG WYVKAASVEA DREKGIGVAKHAAFVFGGVP IFYTPWADFP 251 LDGNRKSGLL VPSLSAGSDG VSLSVPYYFN LAPNLDATFAPSVIGERGAV 301 FDGQVRYLRP DYAGQSDLTW LPHDKKSGRN NRYQAKWQHR HDISDTLQAG351 VDFNQVSDSG YYRDFYGNKE IAGNVNLNRR VWLDYGGRAA GGSLNAGLSV 401LKYQTLANQS GYKDKPYALM PRLSVEWRKN TGRAQIGVSA QFTRFSHDSR 451 QDGSRLVVYPDIKWDFSNSW GYVRPKLGLH ATYYSLNRFG SQEARRVSRT 501 LPIVNIDSGA TFERNTRMFGGEVLQTLEPR LFYNYIPAKS QNDLPNFDSS 551 ESSFGYGQLF RENLYYGNDR INTANSLSAAVQSRILDGAT GEERFRAGIG 601 QKFYFKDDAV MLDGSVGKKP RNRSDWVAFA SGSIGSRFILDSSIHYNQND 651 KRAENYAVGA SYRPAQGKVL NARYKYGRNE KIYLKSDGSY FYDKLSQLDL701 SAQWPLTRNL SAVVRYNYGF EAKKPIEVLA GAEYKSSCGC WGAGVYAQRY 751VTGENTYKNA VFFSLQLKDL SSVGRNPADR MDVAVPGYIT AHSLSAGRNK 801 RP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 958 shows 89.3% identity over a 802 aa overlap with a predicted ORF(ORF 958) from N. gonorrhoeae

m958/g958 89.3% identity in 802 aa overlap          10        20        30        40        50        60 m958.pep  LARLFSLKPLVLALGLCFGTHCAAADAVAAEELDNPTAGESVRSVSEPIQPTSLSLGSTC  |||||||||||||||:|||||||| |:|||||:|: :|  :::::||  | ::|:||||| g958  LARLFSLKPLVLALGFCFGTHCAA-DTVAAEEADGRVAEGGAQGASESAQASDLTLGSTC          10        20         30        40        50          70        80        90       100       110       120 m958.pep  LFCSNESGSPERTEAAVQGSGEASIPEDYTRIVADRMEGQSQVQVRAEGNVVVERNRTTL  ||||||||||||||||||||||||:||||||||||||||||:|:|||||:|::||: ::| g958  LFCSNESGSPERTEAAVQGSGEASVPEDYTRIVADRMEGQSKVKVRAEGSVIIERDGAVL 60        70        80        90       100       110         130       140       150       160       170       180 m958.pep  NTDWADYDQSGDTVTAGDRFALQQDGTLIRGETLTYNLEQQTGEAHNVRMEIEQGGRRLQ  |||||||||||||||:||||||||||||||||||||||:|||||||||||| |||||||| g958  NTDWADYDQSGDTVTVGDRFALQQDGTLIRGETLTYNLDQQTGEAHNVRMETEQGGRRLQ120     130       140       150       160       170         190       200       210       220       230       240 m958.pep  SVSRTAEMLGEGHYKLTETQFNTCSAGDAGWYVKAASVEADREKGIGVAKHAAFVFGGVP  ||||||||||||:||||||||||||||||||||||||||||| ||||||||||||||||| g958  SVSRTAEMLGEGRYKLTETQFNTCSAGDAGWYVKAASVEADRGKGIGVAKHAAFVFGGVP180       190       200       210       220       230         250       260       270       280       290       300 m958.pep  IFYTPWADFPLDGNRKSGLLVPSLSAGSDGVSLSVPYYFNLAPNLDATFAPSVIGERGAV  :||||||||||||||||||||||:||||||||||||||||||||:||||||::||||||: g958  LFYLPWADFPLDGNRKSGLLVPSVSAGSDGVSLSVPYYFNLAPNFDATFAPGIIGERGAT240     250       260       270       280       290         310       320       330       340       350       360 m958.pep  FDGQVRYLRPDYAGQSDLTWLPHDKKSGRNNRYQAKWQHRHDISDTLQAGVDFNQVSDSG  ||||:|||||||:||:|||||||||||||||||||||||||||||||||||||||||||| g958  FDGQIRYLRPDYSGQTDLTWLPHDKKSGRNNRYQAKWQHRHDISDTLQAGVDFNQVSDSG300       310       320       330       340       350         370       380       390       400       410       420 m958.pep  YYRDFYGNKEIAGNVNLNRRVWLDYGGRAAGGSLNAGLSVLKYQTLANQSGYKDKPYALM  |||||||::||||||||||||||||||||||||||||||| ||||||||||||:|||:| g958  YYRDFYGGEEIAGNVNLNRRVWLDYGGRAAGGSLNAGLSVQKYQTLANQSGYKDEPYAIM360       370       380       390       400       410       430       440       450       460       470       480 m958.pep  PRLSVEWRKNTGRAQIGVSAQFTRFSHDSRQDGSRLVVYPDIKWDFSNSWGYVRPKLGLH  ||||::|:||:|||||||||||||||||:||||||||||| ||||||||||||||||||| g958  PRLSADWHKNAGRAQIGVSAQFTRFSHDGRQDGSRLVVYPGIKWDFSNSWGYVRPKLGLH420       430       440       450       460       470         490       500       510       520       530       540 m958.pep  ATYYSLNRFGSQEARRVSRTLPIVNIDSGATFERNTRMFGGEVLQTLEPRLFYNYIPAKS   ||||||:||:: :| |:|:||:||||:|:|||||||:||| |:||:||||||||||||| g958  ATYYSLDSFGGKASRSVGRVLPVVNIDGGTTFERNTRLFGGGVVQTIEPRLFYNYIPAKS480       490       500       510       520       530         550       560       570       580       590       600 m958.pep  QNDLPNFDSSESSFGYGQLFRENLYYGNDRINTANSLSAAVQSRILDGATGEERFRAGIG  ||||||||||||||||||||||||||||||||:|||||:||||||||||||||||||||| g958  QNDLPNFDSSESSFGYGQLFRENLYYGNDRINAANSLSTAVQSRILDGATGEERFRAGIG540       550       560       570       580       590         610       620       630       640       650       660 m958.pep  QKFYFKDDAVMLDGSVGKKPRNRSDWVAFASGSIGSRFILDSSIHYNQNDKRAENYAVGA  ||||||||||||||||||:||:||||||||||:||:|| |||||||||||||||:||||| g958  QKFYFKDDAVMLDGSVGKNPRSRSDWVAFASGGIGGRFTLDSSIHYNQNDKRAEHYAVGA600       610       620       630       640       650         670       680       690       700       710       720 m958.pep  SYRPAQGKVLNARYKYGRNEKIYLKSDGSYFYDKLSQLDLSAQWPLTRNLSAVVRYNYGF  :|||| ||||||||||||||||||::|||||||||||||||||||||||||||||||||| g958  GYRPAPGKVLNARYKYGRNEKIYLQADGSYFYDKLSQLDLSAQWPLTRNLSAVVRYNYGF660       670       680       690       700       710         730       740       750       760       770       780 m958.pep  EAKKPIEVLAGAEYKSSCGCWGAGVYAQRYVTGENTYKNAVFFSLQLKDLSSVGRNPADR  |||||||:|||||||||||||||||||||||||||||||||||||||||||||||||| | g958  EAKKPIEMLAGAEYKSSCGCWGAGVYAQRYVTGENTYKNAVFFSLQLKDLSSVGRNPAGR720       730       740       750       760       770         790       800 m958.pep   MDVAVPGYITAHSLSAGRNKRP  ||||||||| |||||||||||| g958   MDVAVPGYIPAHSLSAGRNKRPX780       790       800The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2933>:

a958.seq 1 TTGGCTCGTT TATTTTCACT CAAACCACTG GTGCTGGCAT TGGGCTTCTG 51TTTCGGCACG CATTGCGCCG CCGCCGATGC CGTTGCGGCG GAGGAAACGG 101 ACAATCCGACCGCCGGAGGA AGCGTTCGGA GCGTGTCCGA ACCCATACAG 151 CCTACCAGCC TGAGCCTCGGTTCGACCTGC CTGTTTTGCA GTAACGAAAG 201 CGGCAGCCCC GAGAGAACCG AAGCCGCCGTCCAAGGCAGC GGCGAAGCAT 251 CCATCCCCGA AGACTATACG CGCATTGTTG CCGACAGGATGGAAGGACAG 301 TCGCAGGTGC AGGTGCGTGC CGAAGGCAAC GTCGTCGTCG AACGCAATCG351 GACGACCCTC AATGCCGATT GGGCGGATTA CGACCAGTCG GGCGACACCG 401TTACCGCAGG CGACCGGTTC GCCCTCCAAC AGGACGGTAC GCTGATTCGG 451 GGCGAAACCCTGACCTACAA TCTCGAGCAG CAGACCGGGG AAGCGCACAA 501 CGTCCGTATG GAAACCGAACACGGCGGACG GCGGCTGCAA AGCGTCAGCC 551 GCACCGCCGA AATGTTGGGC GAAGGGCATTACAAACTGAC GGAAACCCAA 601 TTCAACACCT GTTCCGCCGG CGATGCCGGC TGGTATGTCAAGGCCGCTTC 651 CGTCGAAGCC GATCGGGAAA AAGGCATAGG CGTTGCCAAA CACGCCGCCT701 TCGTGTTCGG CGGCGTTCCC ATTTTCTACA CCCCTTGGGC GGACTTCCCG 751CTTGACGGCA ACCGCAAAAG CGGCCTGCTC GTTCCCTCAC TGTCCGCCGG 801 TTCGGACGGCGTTTCCCTTT CCGTTCCCTA TTATTTCAAC CTTGCCCCCA 851 ATCTCGATGC CACGTTCGCGCCCGGCGTGA TCGGCGAACG CGGCGCGGTC 901 TTTGACGGGC AGGTACGCTA CCTGCGGCCGGATTATGCCG GCCAGTCCGA 951 CCTGACCTGG CTGCCGCACG ACAAGAAAAG CGGCAGGAATAACCGCTATC 1001 AGGCGAAATG GCAGCACCGG CACGACATTT CCGACACGCT TCAGGCGGGT1051 GTCGATTTCA ACCAAGTCTC CGACAGCGGC TACTACCGCG ACTTTTACGG 1101CAACAAAGAA ATCGCCGGCA ACGTCAACCT CAACCGCCGT GTATGGCTGG 1151 ATTATGGCGGCAGGGCGGCG GGCGGCAGCC TGAATGCCGG CCTTTCGGTT 1201 CTGAAATACC AGACGCTGGCAAACCAAAGC GGCTACAAAG ACAAACCGTA 1251 TGCCCTGATG CCGCGCCTTT CCGCCGATTGGCGCAAAAAC ACCGGCAGGG 1301 CGCAAATCGG CGTGTCCGCC CAATTTACCC GCTTCAGCCACGACAGCCGC 1351 CAAGACGGCA GCCGCCTCGT CGTCTATCCC GACATCAAAT GGGATTTCAG1401 CAACAGCTGG GGTTACGTCC GTCCCAAACT CGGACTGCAC GCCACCTATT 1451ACAGCCTCAA CCGCTTCGGC AGCCAAGAAG CCCGACGCGT CAGCCGCACT 1501 CTGCCCATCGTCAACATCGA CAGCGGCATG ACCTTCGAAC GCAATACGCG 1551 GATGTTCGGC GGCGGAGTCCTGCAAACCCT CGAGCCGCGC CTGTTCTACA 1601 ACTATATTCC TGCCAAATCC CAAAACGACCTGCCCAATTT CGATTCGTCG 1651 GAAAGCAGCT TCGGCTACGG GCAGCTTTTT CGTGAAAACCTCTATTACGG 1701 CAACGACAGG ATTAACACCG CAAACAGCCT TTCCGCCGCC GTGCAAAGCC1751 GTATTTTGGA CGGCGCGACG GGGGAAGAGC GTTTCCGCGC CGGCATCGGG 1801CAGAAATTCT ACTTCAAAAA CGACGCAGTC ATGCTTGACG GCAGTGTCGG 1851 CAAAAAACCGCGCAGCCGTT CCGACTGGGT GGCATTCGCC TCCAGCGGCA 1901 TCGGCAGCCG CTTCATCCTCGACAGCAGCA TCCACTACAA CCAAAACGAC 1951 AAACGCGCCG AGAACTACGC CGTCGGTGCAAGCTACCGTC CCGCACAGGG 2001 CAAAGTGCTG AACGCCCGCT ACAAATACGG GCGCAACGAAAAAATCTACC 2051 TGAAGTCCGA CGGTTCCTAT TTTTACGACA AACTCAGCCA GCTCGACCTG2101 TCCGCACAAT GGCCGCTGAC GCGCAACCTG TCGGCCGTCG TCCGTTACAA 2151CTACGGTTTT GAAGCCAAAA AACCGATAGA GGTGCTGGCG GGTGCGGAAT 2201 ACAAAAGCAGTTGCGGCTGC TGGGGCGCGG GCGTGTACGC CCAACGCTAC 2251 GTTACCGGCG AAAACACCTACAAAAACGCT GTCTTTTTCT CACTTCAGTT 2301 GAAAGACCTC AGCAGTGTCG GCAGAAACCCCGCAGACAGG ATGGATGTCG 2351 CCGTTCCCGG CTATATCCCC GCCCACTCTC TTTCCGCCGGACGCAACAAA 2401 CGGCCCTGAThis corresponds to the amino acid sequence <SEQ ID 2934; ORF 958.a>:

a958.pep 1 LARLFSLKPL VLALGFCFGT HCAAADAVAA EETDNPTAGG SVRSVSEPIQ 51PTSLSLGSTC LFCSNESGSP ERTEAAVQGS GEASIPEDYT RIVADRMEGQ 101 SQVQVRAEGNVVVERNRTTL NADWADYDQS GDTVTAGDRF ALQQDGTLIR 151 GETLTYNLEQ QTGEAHNVRMETEHGGRRLQ SVSRTAEMLG EGHYKLTETQ 201 FNTCSAGDAG WYVKAASVEA DREKGIGVAKHAAFVFGGVP IFYTPWADFP 251 LDGNRKSGLL VPSLSAGSDG VSLSVPYYFN LAPNLDATFAPGVIGERGAV 301 FDGQVRYLRP DYAGQSDLTW LPHDKKSGRN NRYQAKWQHR HDISDTLQAG351 VDFNQVSDSG YYRDFYGNKE IAGNVNLNRR VWLDYGGRAA GGSLNAGLSV 401LKYQTLANQS GYKDKPYALM PRLSADWRKN TGRAQIGVSA QFTRFSHDSR 451 QDGSRLVVYPDIKWDFSNSW GYVRPKLGLH ATYYSLNRFG SQEARRVSRT 501 LPIVNIDSGM TFERNTRMFGGGVLQTLEPR LFYNYIPAKS QNDLPNFDSS 551 ESSFGYGQLF RENLYYGNDR INTANSLSAAVQSRILDGAT GEERFRAGIG 601 QKFYFKNDAV MLDGSVGKKP RSRSDWVAFA SSGIGSRFILDSSIHYNQND 651 KRAENYAVGA SYRPAQGKVL NARYKYGRNE KIYLKSDGSY FYDKLSQLDL701 SAQWPLTRNL SAVVRYNYGF EAKKPIEVLA GAEYKSSCGC WGAGVYAQRY 751VTGENTYKNA VFFSLQLKDL SSVGRNPADR MDVAVPGYIP AHSLSAGRNK 801 RP*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 957 shows 96.3% identity over a 377 aa overlap with a predicted ORF(ORF 957) from N. meningitidis

a958/m958 98.1% identity in 802 aa overlap        10        20        30        40        50        60 a958.pepLARLFSLKPLVLALGFCFGTHCAAADAVAAEELDNPTAGGSVRSVSEPIQPTSLSLGSTC|||||||||||||||:||||||||||||||||||||||| |||||||||||||||||||| m958LARLFSLKPLVLALGLCFGTHCAAADAVAAEELDNPTAGESVRSVSEPIQPTSLSLGSTC        10        20        30        40        50        60        70        80        90       100       110       120 a958.pepLFCSNESGSPERTEAAVQGSGEASIPEDYTRIVADRMEGQSQVQVRAEGNVVVERNRTTL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m958LFCSNESGSPERTEAAVQGSGEASIPEDYTRIVADRMEGQSQVQVRAEGNVVVERNRTTL        70        80        90       100       110       120       130       140       150       160       170       180 a958.pepNADWADYDQSGDTVTAGDRFALQQDGTLIRGETLTYNLEQQTGEAHNVRMETEHGGRRLQ|:||||||||||||||||||||||||||||||||||||||||||||||||| |:|||||| m958NTDWADYDQSGDTVTAGDRFALQQDGTLIRGELLTYNLEQQTGEAHNVRMEIEQGGRRLQ       130       140       150       160       170       180       190       200       210       220       230       240 a958.pepSVSRTAEMLGEGHYKLTETQFNTCSAGDAGWYVKAASVEADREKGIGVAKHAAFVFGGVP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m958SVSRTAEMLGEGHYKLTETQFNTCSAGDAGWYVKAASVEADREKGIGVAKHAAFVFGGVP       190       200       210       220       230       240       250       260       270       280       290       300 a958.pepIFYTPWADFPLDGNRKSGLLVPSLSAGSDGVSLSVPYYFNLAPNLDATFAPGVIGERGAV|||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||| m958IFYTPWADFPLDGNRKSGLLVPSLSAGSDGVSLSVPYYFNLAPNLDATFAPSVIGERGAV       250       260       270       280       290       300       310       320       330       340       350       360 a958.pepFDGQVRYLRPDYAGQSDLTWLPHDKKSGRNNRYQAKWQHRHDISDTLQAGVDFNQVSDSG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m958FDGQVRYLRPDYAGQSDLTWLPHDKKSGRNNRYQAKWQHRHDISDTLQAGVDFNQVSDSG       310       320       330       340       350       360       370       380       390       400       410       420 a958.pepYYRDFYGNKEIAGNVNLNRRVWLDYGGRAAGGSLNAGLSVLKYQTLANQSGYKDKPYALM|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m958YYRDFYGNKEIAGNVNLNRRVWLDYGGRAAGGSLNAGLSVLKYQTLANQSGYKDKPYALM       370       380       390       400       410       420       430       440       450       460       470       480 a958.pepPRLSADWRKNTGRAQIGVSAQFTRFSHDSRQDGSRLVVYPDIKWDFSNSWGYVRPKLGLH||||::|||||||||||||||||||||||||||||||||||||||||||||||||||||| m958PRLSVEWRKNTGRAQIGVSAQFTRFSHDSRQDGSRLVVYPDIKWDFSNSWGYVRPKLGLH       430       440       450       460       470       480       490       500       510       520       530       540 a958.pepATYYSLNRFGSQEARRVSRTLPIVNIDSGMTFERNTRMFGGGVLQTLEPRLFYNYIPAKS||||||||||||||||||||||||||||| ||||||||||| |||||||||||||||||| m958ATYYSLNRFGSQEARRVSRTLPIVNIDSGATFERNTRMFGGEVLQTLEPRLFYNYIPAKS       490       500       510       520       530       540       550       560       570       580       590       600 a958.pepQNDLPNFDSSESSFGYGQLFRENLYYGNDRINTANSLSAAVQSRILDGATGEERFRAGIG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m958QNDLPNFDSSESSFGYGQLFRENLYYGNDRINTANSLSAAVQSRILDGATGEERFRAGIG       550       560       570       580       590       600       610       620       630       640       650       660 a958.pepQKFYFKNDAVMLDGSVGKKPRSRSDWVAFASSGIGSRFILDSSIHYNQNDKRAENYAVGA||||||:||||||||||||||:|||||||||::||||||||||||||||||||||||||| m958QKFYFKDDAVMLDGSVGKKPRNRSDWVAFASGSIGSRFILDSSIHYNQNDKRAENYAVGA       610       620       630       640       650       660       670       680       690       700       710       720 a958.pepSYRPAQGKVLNARYKYGRNEKIYLKSDGSYFYDKLSQLDLSAQWPLTRNLSAVVRYNYGF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m958SYRPAQGKVLNARYKYGRNEKIYLKSDGSYFYDKLSQLDLSAQWPLTRNLSAVVRYNYGF       670       680       690       700       710       720       730       740       750       760       770       780 a958.pepEAKKPIEVLAGAEYKSSCGCWGAGVYAQRYVTGENTYKNAVFFSLQLKDLSSVGRNPADR|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m958EAKKPIEVLAGAEYKSSCGCWGAGVYAQRYVTGENTYKNAVFFSLQLKDLSSVGRNPADR       730       740       750       760       770       780       790       800 a958.pep MDVAVPGYIPAHSLSAGRNKRPX||||||||| |||||||||||| m958 MDVAVPGYITAHSLSAGRNKRP        790       800The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2935>:

g959.seq 1 ATGAACATCA AACACCTTCT CTTGACCGCC GCCGCAACCG CACTGTTGGG 51CATTTCCGCC CCCGCACTCG CCCACCACGA CGGACACGGC GATGACGACC 101 ACGGACACGCCGCACACCAA CACGGCAAAC AAGACAAAAT CATCAGCCGC 151 GCCCAAGCCG AAAAAGCGGCTTGGGCGCGT GTCGGCGGCA AAATCACCGA 201 CATCGATCTC GAACACGACG ACGGCCGTCCGCACTATGAT GTCGAAATCG 251 TCAAAAACGG ACAGGAATAC AAAGTCGTTG TCGATGCCCGTACCGGCCGC 301 GTGATTTCCT CCCGCCGCGA CGACTGAThis corresponds to the amino acid sequence <SEQ ID 2936; ORF 959.ng>:

g959.pep 1 MNIKHLLLTA AATALLGISA PALAHHDGHG DDDHGHAAHQ HGKQDKIISR 51AQAEKAAWAR VGGKITDIDL EHDDGRPHYD VEIVKNGQEY KVVVDARTGR 101 VISSRRDD*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2937>:

m959.seq 1 ATGAACATCA AACACCTTCT CTTGACCTCC GCCGCAACCG CACTGCTGAG 51CATTTCCGCC CCCGCGCTCG CCCACCACGA CGGACACGGC GATGACGACC 101 ACGGACACGCCGCACACCAA CACAACAAAC AAGACAAAAT CATCAGCCGC 151 GCCCAAGCCG AAAAAGCAGCGTTGGCGCGT GTCGGCGGCA AAATCACCGA 201 CATCGATCTC GAACACGACA ACGGCCGTCCGCACTATGAT GTCGAAATCG 251 TCAAAAACGG ACAGGAATAC AAAGTCGTTG TCGATGCCCGTACCGGCCGC 301 GTGATTTCCT CCCGCCGCGA CGACTGAThis corresponds to the amino acid sequence <SEQ ID 2938; ORF 959>:

m959.pep 1 MNIKHLLLTS AATALLSISA PALAHHDGHG DDDHGHAAHQ HNKQDKIISR 51AQAEKAALAR VGGKITDIDL EHDNGRPHYD VEIVKNGQEY KVVVDARTGR 101 VISSRRDD*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 959 shows 95.4% identity over a 108 aa overlap with a predicted ORF(ORF 959) from N. gonorrhoeae

m959/g959 95.4% identity in 108 aa overlap        10        20        30        40        50        60 m959.pepMNIKHLLLTSAATALLSISAPALAHHDGHGDDDHGHAAHQHNKQDKIISRAQAEKAALAR|||||||||:||||||:||||||||||||||||||||||||:||||||||||||||| || g959MNIKHLLLTAAATALLGISAPALAHHDGHGDDDHGHAAHQHGKQDKIISRAQAEKAAWAR        10        20        30        40        50        60        70        80        90       100      109 m959.pepVGGKITDIDLEHDNGRPHYDVEIVKNGQEYKVVVDARTGRVISSRRDDX|||||||||||||:||||||||||||||||||||||||||||||||||| g959VGGKITDIDLEHDDGRPHYDVEIVKNGQEYKVVVDARTGRVISSRRDDX        70        80        90       100The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2939>:

a959.seq 1 ATGAACTTCA AACGCCTTCT CTTGACCGCC GCCGCAACCG CACTGATGGG 51CATTTCCGCC CCCGCACTCG CCCACCACGA CGGACACGGC GATGACGACC 101 ACGGACACGCCGCACACCAA CACAGCAAAC AAGACAAAAT CATCAGCCGC 151 GCCCAAGCCG AAAAAGCAGCGTTGGCGCGT GTCGGCGGCA AAATCACCGA 201 CATCGATCTC GAACACGACA ACGGCCGTCCGCACTATGAT GTCGAAATCG 251 TCAAAAACGG ACAGGAATAC AAAGTCGTTG TCGATGCCCGTACCGGCCGC 301 GTGATTTCCT CCCGCCGCGA CGACTGAThis corresponds to the amino acid sequence <SEQ ID 2940; ORF 959.a>:

a959.pep 1 MNFKRLLLTA AATALMGISA PALAHHDGHG DDDHGHAAHQ HSKQDKIISR 51AQAEKAALAR VGGKITDIDL EHDNGRPHYD VEIVKNGQEY KVVVDARTGR 101 VISSRRDD*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 959 shows 94.4% identity over a 108 aa overlap with a predicted ORF(ORF 959) from N. meningitidis

a959/m959 94.4% identity in 108 aa overlap        10        20        30        40        50        60 a959.pepMNFKRLLLTAAATALMGISAPALAHHDGHGDDDHGHAAHQHSKQDKIISRAQAEKAALAR||:|:||||:|||||::||||||||||||||||||||||||:|||||||||||||||||| m959MNIKHLLLTSAATALLSISAPALAHHDGHGDDDHGHAAHQHNKQDKIISRAQAEKAALAR        10        20        30        40        50        60        70        80        90       100      109 a959.pepVGGKITDIDLEHDNGRPHYDVEIVKNGQEYKVVVDARTGRVISSRRDDX||||||||||||||||||||||||||||||||||||||||||||||||| m959VGGKITDIDLEHDNGRPHYDVEIVKNGQEYKVVVDARTGRVISSRRDDX        70        80        90       100

g960.seq not found yet

g960.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2941>:

m960.seq 1 ATGCAAGTAA ATATTCAGAT TCCCTGTATG CTGTACAGAC GCGGGAGTGT 51TAAGCCCCCC TTGTTTGAAG CTCCGCGGCT CCTGCCGAGC TTCACCGACC 101 CCGTTGTGCCCAAGCTCTCT GCTCCCGGCG GCTACATTGT CGACATCCCC 151 AAAGGCAATC TGAAAACCGAAATCGAAAAG CTGGCCAAAC AGCCCGAGTA 201 TGCCTATCTG AAACAGCTCC AAGTAGCGAAAAACGTCAAC TGGAACCAGG 251 TGCAACTGGC TTACGATAAA TGGGACTATA AGCAGGAAGGCTTAACCAGA 301 GCCGGTGCAG CGATTATCGC GCTGGCTGTT ACCGTGGTTA CTGCGGGCGC351 GGGAGTCGGA GCCGCACTAG GCTTAAACGG CGCAGCCGCA GCAGCGGCCG 401ATGCCGCCTT TGCCTCACTC GCTTCTCAGG CTTCCGTATC GCTCATCAAC 451 AATAAAGGCGATGTCGGCAA AACCCTGAAG GAACTGGGCA GAAGCCGCAC 501 GGTAAAAAAT CTGGTTGTAGCGGCGGCAAC GGCAGGCGTA TCCAACAAAC 551 TCGGTGCCTC TTCCCTTGCC ACTTGGAGCGAAACCCCTTG GGTAAACAAC 601 CTCAACGTTA ACCTGGCCAA TGCGGGCAGT GCCGCGCTGATCAACACCGC 651 TGTTAACGGC GGCAGCCTGA AAGACAATCT GGAGGCAAAT ATCCTGGCGG701 CATTGGTGAA TACCGCGCAT GGGGAGGCGG CGAGTAAGAT CAAAGGACTG 751GATCAGCACT ATGTCGCCCA CAAAATCGCT CATGCCGTAG CGGGCTGTGC 801 GGCTGCAGCGGCGAATAAGG GCAAATGTCA GGACGGCGCG ATCGGTGCGG 851 CTGTGGGTGA GATTGTCGGGGAGGCTTTGG TTAAAAATAC CGATTTTAGC 901 GATATGACCC CGGAACAATT AGATCTGGAAGTTAAGAAAA TTACCGCCTA 951 TGCCAAACTT GCGGCAGGTA CAGTTGCAGG CGTAACGGGAGGAGATGTCA 1001 ATACTGCTGC ACAAACCGCA CAAAACGCGG TAGAAAATAA TGCGGTTAAA1051 GCTGTTGTAA CTGCTGCAAA AGTGGTTTAT AAGGTAGCCA GAAAAGGATT 1101AAAAAACGGG AAAATCAACG TTAGAGATTT AAAACAGACG TTGAAAGACG 1151 AAGGTTATAATTTAGCCGAC AACCTGACCA CCTTATTCGA CGAAACATTG 1201 GATTGGAACG ATGCCAAAGCCGTTATTGAT ATTGTCGTCG GAACAGAGCT 1251 GAATCGCGCT AATAAAGGGG AAGCGGCACAAAAGGTCAAG GAAGTTTTAG 1301 AAAAAAATCG TCCTTATATC CCTAATAAAG GTGCTGTACCGAATATGAGT 1351 ACATACATGA AAAATAATCC TTTTGGAAAA CAGCTGGCTC AAATTTCAGA1401 AAAGACAACG CTTCCGACGC AGCAAGGGCA GTCTGTCTTC TTGGTAAAAA 1451GAAACCAAGG GTTATTAAAA ACCGGTGATA GGTTTTATTT AGATGGCCAA 1501 CATAAAAATCATTTAGAGGT TTTTGATAAA AATGGGAACT TTAAGTTTGT 1551 TCTAAATATG GATGGTTCGCTTAACCAAAT GAAAACTGGG GCAGCAAAAG 1601 GTCGTAAATT AAACTTAAAA TAGThis corresponds to the amino acid sequence <SEQ ID 2942; ORF 960>:

m960.pep 1 MQVNIQIPCM LYRRGSVKPP LFEAPRLLPS FTDPVVPKLS APGGYIVDIP 51KGNLKTEIEK LAKQPEYAYL KQLQVAKNVN WNQVQLAYDK WDYKQEGLTR 101AGAAIIALAV TVVTAGAGVG AALGLNGAAA AAADAAFASL ASQASVSLIN 151 NKGDVGKTLKELGRSRTVKN LVVAAATAGV SNKLGASSLA TWSETPWVNN 201 LNVNLANAGS AALINTAVNGGSLKDNLEAN ILAALVNTAH GEAASKIKGL 251 DQHYVAHKIA HAVAGCAAAA ANKGKCQDGAIGAAVGEIVG EALVKNTDFS 301 DMTPEQLDLE VKKITAYAKL AAGTVAGVTG GDVNTAAQTAQNAVENNAVK 351 AVVTAAKVVY KVARKGLKNG KINVRDLKQT LKDEGYNLAD NLTTLFDETL401 DWNDAKAVID IVVGTELNRA NKGEAAQKVK EVLEKNRPYI PNKGAVPNMS 451TYMKNNPFGK QLAQISEKTT LPTQQGQSVF LVKRNQGLLK TGDRFYLDGQ 501 HKNHLEVFDKNGNFKFVLNM DGSLNQMKTG AAKGRKLNLK *

a960.seq not found yet

a960.pep not found yet

g961.seq not found yet

g961.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2943>:

m961.seq 1 ATGAGCATGA AACACTTTCC AGCCAAAGTA CTGACCACAG CCATCCTTGC 51CACTTTCTGT AGCGGCGCAC TGGCAGCCAC AAGCGACGAC GATGTTAAAA 101 AAGCTGCCACTGTGGCCATT GTTGCTGCCT ACAACAATGG CCAAGAAATC 151 AACGGTTTCA AAGCTGGAGAGACCATCTAC GACATTGGTG AAGACGGCAC 201 AATTACCCAA AAAGACGCAA CTGCAGCCGATGTTGAAGCC GACGACTTTA 251 AAGGTCTGGG TCTGAAAAAA GTCGTGACTA ACCTGACCAAAACCGTCAAT 301 GAAAACAAAC AAAACGTCGA TGCCAAAGTA AAAGCTGCAG AATCTGAAAT351 AGAAAAGTTA ACAACCAAGT TAGCAGACAC TGATGCCGCT TTAGCAGATA 401CTGATGCCGC TCTGGATGAA ACCACCAACG CCTTGAATAA ATTGGGAGAA 451 AATATAACGACATTTGCTGA AGAGACTAAG ACAAATATCG TAAAAATTGA 501 TGAAAAATTA GAAGCCGTGGCTGATACCGT CGACAAGCAT GCCGAAGCAT 551 TCAACGATAT CGCCGATTCA TTGGATGAAACCAACACTAA GGCAGACGAA 601 GCCGTCAAAA CCGCCAATGA AGCCAAACAG ACGGCCGAAGAAACCAAACA 651 AAACGTCGAT GCCAAAGTAA AAGCTGCAGA AACTGCAGCA GGCAAAGCCG701 AAGCTGCCGC TGGCACAGCT AATACTGCAG CCGACAAGGC CGAAGCTGTC 751GCTGCAAAAG TTACCGACAT CAAAGCTGAT ATCGCTACGA ACAAAGCTGA 801 TATTGCTAAAAACTCAGCAC GCATCGACAG CTTGGACAAA AACGTAGCTA 851 ATCTGCGCAA AGAAACCCGCCAAGGCCTTG CAGAACAAGC CGCGCTCTCC 901 GGCCTGTTCC AACCTTACAA CGTGGGTCGGTTCAATGTAA CGGCTGCAGT 951 CGGCGGCTAC AAATCCGAAT CGGCAGTCGC CATCGGTACCGGCTTCCGCT 1001 TTACCGAAAA CTTTGCCGCC AAAGCAGGCG TGGCAGTCGG CACTTCGTCC1051 GGTTCTTCCG CAGCCTACCA TGTCGGCGTC AATTACGAGT GGTAAThis corresponds to the amino acid sequence <SEQ ID 940; ORF 2944>:

m961.pep 1 MSMKHFPAKV LTTAILATFC SGALAATSDD DVKKAATVAI VAAYNNGQEI 51NGFKAGETIY DIGEDGTITQ KDATAADVEA DDFKGLGLKK VVTNLTKTVN 101 ENKQNVDAKVKAAESEIEKL TTKLADTDAA LADTDAALDE TTNALNKLGE 151 NITTFAEETK TNIVKIDEKLEAVADTVDKH AEAFNDIADS LDETNTKADE 201 AVKTANEAKQ TAEETKQNVD AKVKAAETAAGKAEAAAGTA NTAADKAEAV 251 AAKVTDIKAD IATNKADIAK NSARIDSLDK NVANLRKETRQGLAEQAALS 301 GLFQPYNVGR FNVTAAVGGY KSESAVAIGT GFRFTENFAA KAGVAVGTSS351 GSSAAYHVGV NYEW*

a961.seq not found yet

a961.pep not found yet

g972.seq not found yet

g972.pep not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2945>:

m972.seq 1 TTGACTAACA GGGGGGGAGC GAAATTAAAA ACCArTTCCA AGAGTAGTGA 51ACGAATGAGT GAAGTTGAAT ATTTCTCACA CTTTATATCG GACGGAAAAG 101 GGAAGCTTTTAGAAATTCCG CAGCGAAGAG GTAAGCAAGA CggGGTTTTT 151 GTTGATTGGA TTTCATTCACATTCCATGAA GATACTTTAC TGAAAGTTTC 201 CGGTTGCCCT TTATTTTCTG ATGCTGAATACATGTATGTA TTAAGCAGAA 251 AGCTGGAAGA AATTCTAGGT TTTGGCATAA CGCGCAAATGCAAATCAAGG 301 GGCAACAAAT TCTATGAATC CATGTATAGG TTAGGTTCGG ATGATGTTGA351 TTATGGAGAG GTGCATTTCG GArGTCAGCG CAATACTGTT TTAGTTGAGT 401TGAAAGGTAC TGGTTGCAGC GTTGCAAGTC CGGGTTGGGA GTTGAGGCTA 451 AAGCAGTTTCTCGATGATTC GATAAGGACA AGAATAACGC GAATTGACCT 501 AGCACTTGAT TTTTTTGATGGAGAGTACAC GCCGGATCAG GCGTTGTTAG 551 ATCACGATAA TGGTTTTTTT GATAACAGCAATCAAAGGCC GAAATCTGAA 601 ACGATCGGTA CGGCTTGGCG GAATGAGGAC GGGAGCGGCAAGACATTTTA 651 TGTAGGTCGC AAGAAAAATT CTCGTTTTGT TCGTGTTTAT GAGAAAGGCA701 GGCAGCTTGG AGATAAAGAA AGCAAATGGG TAAGGTTCGA GATCCAGTTT 751AATTATGGAG ATATAGAAAT ACCCTTGGAT ATTTTAATAA ATCAGGGTTC 801 GTATTTCTGTGGAGCTTTTC CAATTTGTAG AAAATTTAAA AATATGCCGG 851 TTCCCGAAAG GTTTGATCAGAGAAAGAAAA AGCTTAATTT AACTTTCGAG 901 CATAAATTGC ATTACGCGAA AAACGCGGTTGGAAAACTGG TCAATTTCAT 951 GATTGAAATG GGTTTTGATA ATAGCGAAAT TGTGGAATCTTTAAAGGCAG 1001 ATTCGGGATT TCCCAAAGGA TTAGAACCTG AAAAATATGC TCTGGAAATG1051 TTAAGGGACG GTTTGAAACA CGGTTTTATT CATGAACAGC CGGATATTGA 1101TTTGGAAATT GAACTTGATG AATTGGGGGT TATTGCTTTT AAAAATTCTG 1151 ACAAATTCGATAGGGAAAAA AGGCTTTTTA GTCCTGATTA TGATGTCGAG 1201 AAAGAAAGGA AATATCAGGAATATTTAAGT AAAGTTTATC ATCAAAATGT 1251 AGATTATGAT TATTTTTAAThis corresponds to the amino acid sequence <SEQ ID 2946; ORF 972>:

m972.pep 1 LTNRGGAKLK TXSKSSERMS EVEYFSHFIS DGKGKLLEIP QRRGKQDGVF 51VDWISFTFHE DTLLKVSGCP LFSDAEYMYV LSRKLEEILG FGITRKCKSR 101 GNKFYESMYRLGSDDVDYGE VHFGXQRNTV LVELKGTGCS VASPGWELRL 151 KQFLDDSIRT RITRIDLALDFFDGEYTPDQ ALLDHDNGFF DNSNQRPKSE 201 TIGTAWRNED GSGKTFYVGR KKNSRFVRVYEKGRQLGDKE SKWVRFEIQF 251 NYGDIEIPLD ILINQGSYFC GAFPICRKFK NMPVPERFDQRKKKLNLTFE 301 HKLHYAKNAV GKLVNFMIEM GFDNSEIVES LKADSGFPKG LEPEKYALEM351 LRDGLKHGFI HEQPDIDLEI ELDELGVIAF KNSDKFDREK RLFSPDYDVE 401KERKYQEYLS KVYHQNVDYD YF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2947>:

a972.seq 1 TTGACTAACA GGGGGGGAGC GAAATTAAAA ACCAATTCCA AGAGTAGTGA 51ACGAATGAGT GAAGTTGAAT ATTTCTCACA CTTTATATCG GACGGAAAAG 101 GGAAGCTTTTAGAAATTCCG CAGCGAAGAG GTAAGCAAGA CGGGGTTTTT 151 GTTGATTGGA TTTCATTCACATTCCATGAA GATACTTTAC TGAAAGTTTC 201 CGGTTGCCCT TTATTTTCTG ATGCTGAATACATGTATGTA TTAAGCAGAA 251 AGCTGGAAGA AATTCTAGGT TTTGGCATAA CGCGCAAATGCAAATCAAGG 301 GGCAACAAAT TCTATGAATC CATGTATAGG TTAGGTTCGG ATGATGTTGA351 TTATGGAGAG GTGCATTTCG GAGGTCAGCG CAATACTGTT TTAGTTGAGT 401TGAAAGGTAC TGGTTGCAGC GTTGCAAGTC CGGGTTGGGA GTTGAGGCTA 451 AAGCAGTTTCTCGATGATTC GATAAGGACA AGAATAACGC GAATTGACCT 501 AGCACTTGAT TTTTTTGATGGAGAGTACAC GCCGGATCAG GCGTTGTTAG 551 ATCACGATAA TGGTTTTTTT GATAACAGCAATCAAAGGCC GAAATCTGAA 601 ACGATCGGTA CGGCTTGGCG GAATGAGGAC GGGAGCGGCAAGACATTTTA 651 TGTAGGTCGC AAGAAAAATT CTCGTTTTGT TCGTGTTTAT GAGAAAGGCA701 GGCAGCTTGG AGATAAAGAA AGCAAATGGG TAAGGTTCGA GATCCAGTTT 751AATTATGGAG ATATAGAAAT ACCCTTGGAT ATTTTAATAA ATCAGGGTTC 801 GTATTTCTGTGGAGCTTTTC CAATTTGTAG AAAATTTAAA AATATGCCGG 851 TTCCCGAAAG GTTTGATCAGAGAAAGAAAA CGCTTAATTT AACTTTCGAG 901 CATAAATTGC ATTACGCGAA AAACGCGGTTGGAAAACTGG TCAATTTCAT 951 GATTGAAATG GGTTTTGATA ATAGCGAAAT TGTGGAATCTTTAAAGGCAG 1001 ATTCGGGATT TCCCAAAGGA TTAGAACCTG AAAAATATGC TCTGGAAATG1051 TTAAGGGACG GTTTGAAACA CGGTTTTATT CATGAACAGC CGGATATTGA 1101TTTGGAAATT GAACTTGATG AATTGGGGGT TATTGCTTTT AAAAATTCTG 1151 ACAAATTCGATAGGGAAAAA AGGCTTTTTA GTCCTGATTA TGATGTCGAG 1201 AAAGAAAGGA AATATCAGGAATATTTAAGT AAAGTTTATC ATCAAAATGT 1251 AGATTATGAT TATTTTTAAThis corresponds to the amino acid sequence <SEQ ID 2948; ORF 972.a>:

a972.pep 1 LTNRGGAKLK TNSKSSERMS EVEYFSHFIS DGKGKLLEIP QRRGKQDGVF 51VDWISFTFHE DTLLKVSGCP LFSDAEYMYV LSRKLEEILG FGITRKCKSR 101 GNKFYESMYRLGSDDVDYGE VHFGGQRNTV LVELKGTGCS VASPGWELRL 151 KQFLDDSIRT RITRIDLALDFFDGEYTPDQ ALLDHDNGFF DNSNQRPKSE 201 TIGTAWRNED GSGKTFYVGR KKNSRFVRVYEKGRQLGDKE SKWVRFEIQF 251 NYGDIEIPLD ILINQGSYFC GAFPICRKFK NMPVPERFDQRKKTLNLTFE 301 HKLHYAKNAV GKLVNFMIEM GFDNSEIVES LKADSGFPKG LEPEKYALEM351 LRDGLKHGFI HEQPDIDLEI ELDELGVIAF KNSDKFDREK RLFSPDYDVE 401KERKYQEYLS KVYHQNVDYD YF* m972/a972 99.3% identity in 422 aa overlap        10        20        30        40        50        60 m972.pepLTNRGGAKLKTXSKSSERMSEVEYFSHFISDGKGKLLEIPQRRGKQDGVFVDWISFTFHE||||||||||| |||||||||||||||||||||||||||||||||||||||||||||||| a972LINRGGAKLKINSKSSERMSEVEYFSHFISDGKGKLLEIPQRRGKQDGVFVDWISFIFHE        10        20        30        40        50        60        70        80        90       100       110       120 m972.pepDTLLKVSGCPLFSDAEYMYVLSRKLEEILGFGITRKCKSRGNKFYESMYRLGSDDVDYGE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a972DILLKVSGCPLFSDAEYMYVLSRKLEEILGFGITRKCKSRGNKFYESMYRLGSDDVDYGE        70        80        90       100       110       120       130       140       150       160       170       180 m972.pepVHFGXQRNTVLVELKGTGCSVASPGWELRLKQFLDDSIRTRITRIDLALDFFDGEYTPDQ|||| ||||||||||||||||||||||||||||||||||||||||||||||||||||||| a972VHFGGQRNTVLVELKGIGCSVASPGWELRLKQFLDDSIRTRITRIDLALDFFDGEYTPDQ       130       140       150       160       170       180       190       200       210       220       230       240 m972.pepALLDHDNGFFDNSNQRPKSETIGTAWRNEDGSGKTFYVGRKKNSRFVRVYEKGRQLGDKE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a972ALLDHDNGFFDNSNQRPKSETIGTAWRNEDGSGKTFYVGRKKNSRFVRVYEKGRQLGDKE       190       200       210       220       230       240       250       260       270       280       290       300 m972.pepSKWVRFEIQFNYGDIEIPLDILINQGSYFCGAFPICRKFKNMPVPERFDQRKKKLNLTFE||||||||||||||||||||||||||||||||||||||||||||||||||||| |||||| a972SKWVRFEIQFNYGDIEIPLDILINQGSYFCGAFPICRKFKNMPVPERFDQRKKTLNLTFE       250       260       270       280       290       300       310       320       330       340       350       360 m972.pepHKLHYAKNAVGKLVNFMIEMGFDNSEIVESLKADSGFPKGLEPEKYALEMLRDGLKHGFI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a972HKLHYAKNAVGKLVNFMIEMGFDNSEIVESLKADSGFPKGLEPEKYALEMLRDGLKHGFI       310       320       330       340       350       360       370       380       390       400       410       420 m972.pepHEQPDIDLEIELDELGVIAFKNSDKFDREKRLFSPDYDVEKERKYQEYLSKVYHQNVDYD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a972HEQPDIDLEIELDELGVIAFKNSDKFDREKRLFSPDYDVEKERKYQEYLSKVYHQNVDYD       370       380       390       400       410       420 m972.pepYFX ||| a972 YFXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2949>:

g973.seq 1 ATGGACGGCG CACAACCGAA AACAAATTTT TTTGAACGCC TGATTGCCCG 51actCGCCCGC GAACCCGATT CCGCCGAAGA CGTATTAAAC CTGCTTCGGC 101 AGGCGCACGAACAGGAAGTT TTTGATGCCG ACACACTGAC CCGGCTGGAA 151 AAAGTATTGG ACTTTGCCGAGCTGGAAGTG CGCGATGCGA TGATTACGCG 201 CAGCCGCATG AACGTATTGA AAGAAAACGACAGCATCGAA CGCATCACCG 251 CCTACGTCAT CGATACCGCC CATTCGCGCT TCCCCGTCATCGGCGAAGAC 301 AAAGACGAAG TTTTGGGCAT TTTGCACGCC AAAGACCTGC TCAAATATAT351 GTTCAACCCC GAGCAGTTCC ACCTGAAATC CGTCTTGCGC CCTGCCGTTT 401TCGTGCCCGA AGGCAAATCT TTGACCGCCC TTTTAAAAGA GTTCCGCGAA 451 CAGCGCAACCATATGGCAAT CGTCATCGAC GAATACGGCG GCACGTCGGG 501 TTTGGTCACC TTTGAAGACATCATCGAGCa aatcgtcggt gacaTCGAAG 551 ACGAGTTTGA CGAAGACGAA AGCGccgacgacatCCACTC cgTTTccgCC 601 GAACGCTGGC GCATCCacgc ggctaCCGAA ATCGAAGacaTCAACGCCTT 651 TTTCGGTACG GAatacggca gcgaagaagc cgacaccatc ggcggctTGG701 TCATTCAGGA ATTGGGACAC CTGCCCGTGC GCGGCGAAAA AGTCCTTAtc 751ggcgGTTTGC agttcaccgt CGCCCGCGCC GACAACCGCC GCCTGCACAC 801 GCTGATGGCGACCCGCGTGA AGTAAGCAGA GCCTGCCcgc accgccgttT 851 CTGCacAGTT TAGThis corresponds to the amino acid sequence <SEQ ID 2950; ORF 973.ng>:

g973.pep 1 MDGAQPKTNF FERLIARLAR EPDSAEDVLN LLRQAHEQEV FDADTLTRLE 51KVLDFAELEV RDAMITRSRM NVLKENDSIE RITAYVIDTA HSRFPVIGED 101 KDEVLGILHAKDLLKYMFNP EQFHLKSVLR PAVFVPEGKS LTALLKEFRE 151 QRNHMAIVID EYGGTSGLVTFEDIIEQIVG DIEDEFDEDE SADDIHSVSA 201 ERWRIHAATE IEDINAFFGT EYGSEEADTIGGLVIQELGH LPVRGEKVLI 251 GGLQFTVARA DNRRLHTLMA TRVK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2951>:

m973.seq 1 ATGGACGGCG CACAACCGAA AACGAATTTT TTTGAACGCC TGATTGCCCG 51ACTCGCCCGC GAACCCGATT CCGCCGAAGA CGTATTAAAC CTGCTTCGGC 101 AGGCGCACGAGCAGGAAGTT TTTGATGCGG ATACGCTTTT AAGATTGGAA 151 AAAGTCCTCG ATTTTTCCGATTTGGAAGTG CGCGACGCGA TGATTACGCG 201 CAGCCGTATG AACGTTTTAA AAGAAAACGACAGCATCGAG CGCATCACCG 251 CCTACGTTAT CGATACCGCC CATTCGCGCT TCCCCGTCATCGGCGAAGAC 301 AAAGACGAAG TTTTGGGCAT TTTGCACGCC AAAGACCTGC TCAAATATAT351 GTTTAACCCC GAGCAGTTCC ACCTCAAATC CATTCTCCGC CCCGCCGTCT 401TCGTCCCCGA AGGCAAATCG CTGACCGCCC TTTTAAAAGA GTTCCGCGAA 451 CAGCGCAACCATATGGCGAT TGTCATCGAC GAATACGGCG GCACATCCGG 501 CTTGGTCACC TTTGAAGACATCATCGAGCA AATCGTCGGC GAAATCGAAG 551 ACGAGTTTGA CGAAGACGAT AGCGCCGACAATATCCATGC CGTTTCTTCm 601 GaACGcTGGC GCATCCATGC AGCTACCGAA ATCGAAGACATCAACACCTT 651 CTTCGGCACG GAATACAGCA kCGAAGAAGC CGACACCATT GGCGGCCTGG701 TCATTCAAGA GTTGGGACAT CTGCCCGTGC GCGGCGAAAA AGTCCTTATC 751GGCGGTTTGC AGTTCACCGT CGCACGCGCC GACAACCGCC GCCTGCATAC 801 GCTGATGGCGACCCGCGTGA AGTAAThis corresponds to the amino acid sequence <SEQ ID 2952; ORF 973>:

m973.pep 1 MDGAQPKTNF FERLIARLAR EPDSAEDVLN LLRQAHEQEV FDADTLLRLE 51KVLDFSDLEV RDAMITRSRM NVLKENDSIE RITAYVIDTA HSRFPVIGED 101 KDEVLGILHAKDLLKYMFNP EQFHLKSILR PAVFVPEGKS LTALLKEFRE 151 QRNHMAIVID EYGGTSGLVTFEDIIEQIVG EIEDEFDEDD SADNIHAVSS 201 ERWRIHAATE IEDINTFFGT EYSXEEADTIGGLVIQELGH LPVRGEKVLI 251 GGLQFTVARA DNRRLHTLMA TRVK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 973 shows 95.6% identity over a 274 aa overlap with a predicted ORF(ORF 973.ng) from N. gonorrhoeae:

m973/g973         10        20        30        40        50        60m973.pep MDGAQPKTNFFERLIARLAREPDSAEDVLNLLRQAHEQEVFDADTLLRLEKVLDFSDLEV|||||||||||||||||||||||||||||||||||||||||||||| ||||||||::||| g973MDGAQPKTNFFERLIARLAREPDSAEDVLNLLRQAHEQEVFDADTLTRLEKVLDFAELEV        10        20        30        40        50        60        70        80        90       100       110       120 m973.pepRDAMITRSRMNVLKENDSIERITAYVIDTAHSRFPVIGEDKDEVLGILHAKDLLKYMFNP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g973RDAMITRSRMNVLKENDSIERITAYVIDTAHSRFPVIGEDKDEVLGILHAKDLLKYMFNP        70        80        90       100       110       120       130       140       150       160       170       180 m973.pepEQFHLKSILRPAVFVPEGKSLTALLKEFREQRNHMAIVIDEYGGTSGLVTFEDIIEQIVG|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||| g973EQFHLKSVLRPAVFVPEGKSLTALLKEFREQRNHMAIVIDEYGGISGLVTFEDIIEQIVG       130       140       150       160       170       180       190       200       210       220       230       240 m973.pepEIEDEFDEDDSADNIHAVSSERWRIHAATEIEDINTFFGTEYSXEEADTIGGLVIQELGH:||||||||:|||:||:||:|||||||||||||||:||||||: |||||||||||||||| g973DIEDEFDEDESADDIHSVSAERWRIHAATEIEDINAFFGTEYGSEEADTIGGLVIQELGH       190       200       210       220       230       240       250       260       270 m973.pepLPVRGEKVLIGGLQFTVARADNRRLHTLMATRVKX |||||||||||||||||||||||||||||||||||g973 LPVRGEKVLIGGLQFTVARADNRRLHTLMATRVKX        250       260       270The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2953>:

a973.seq 1 ATGGACGGCG CACAACCGAA AACAAATTTT TTTGAACGCC TGATTGCCCG 51ACTCGCCCGC GAACCCGATT CCGCCGAAGA CGTATTGACC CTGTTGCGCC 101 AAGCGCACGAACAGGAAGTA TTTGATGCGG ATACGCTTTT AAGATTGGAA 151 AAAGTCCTCG ATTTTTCTGATTTGGAAGTG CGCGACGCGA TGATTACGCG 201 CAGCCGTATG AACGTTTTAA AAGAAAACGACAGCATCGAA CGCATCACCG 251 CCTACGTTAT CGATACCGCC CATTCGCGCT TCCCCGTCATCGGTGAAGAC 301 AAAGACGAAG TTTTGGGTAT TTTGCACGCC AAAGACCTGC TCAAATATAT351 GTTCAACCCC GAGCAGTTCC ACCTCAAATC GATATTGCGC CCTGCCGTCT 401TCGTCCCCGA AGGCAAATCG CTGACCGCCC TTTTAAAAGA GTTCCGCGAA 451 CAGCGCAACCATATGGCAAT CGTCATCGAC GAATACGGCG GCACGTCGGG 501 TTTGGTAACT TTTGAAGACATCATCGAGCA AATCGTCGGC GACATCGAAG 551 ATGAGTTTGA CGAAGACGAA AGCGCGGACAACATCCACGC CGTTTCCGCC 601 GAACGCTGGC GCATCCACGC GGCTACCGAA ATCGAAGACATCAACGCCTT 651 TTTCGGCACG GAATACAGCA GCGAAGAAGC CGACACCATC GGCGGCCTGG701 TCATTCAGGA ATTGGGACAC CTGCCCGTGC GCGGCGAAAA AGTCCTTATC 751GGCGGTTTGC AGTTCACCGT CGCCCGCGCC GACAACCGCC GCCTGCATAC 801 GCTGATGGCGACCCGCGTGA AGTAAThis corresponds to the amino acid sequence <SEQ ID 2954; ORF 973.a>:

a973.pep 1 MDGAQPKTNF FERLIARLAR EPDSAEDVLT LLRQAHEQEV FDADTLLRLE 51KVLDFSDLEV RDAMITRSRM NVLKENDSIE RITAYVIDTA HSRFPVIGED 101 KDEVLGILHAKDLLKYMFNP EQFHLKSILR PAVFVPEGKS LTALLKEFRE 151 QRNHMAIVID EYGGTSGLVTFEDIIEQIVG DIEDEFDEDE SADNIHAVSA 201 ERWRIHAATE IEDINAFFGT EYSSEEADTIGGLVIQELGH LPVRGEKVLI 251 GGLQFTVARA DNRRLHTLMA TRVK* m973/a973 97.8%identity in 274 aa overlap        10        20        30        40        50        60 m973.pepMDGAQPKTNFFERLIARLAREPDSAEDVLNLLRQAHEQEVFDADTLLRLEKVLDFSDLEV|||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||| a973MDGAQPKTNFFERLIARLAREPDSAEDVLTLLRQAHEQEVFDADTLLRLEKVLDFSDLEV        10        20        30        40        50        60        70        80        90       100       110       120 m973.pepRDAMITRSRMNVLKENDSIERITAYVIDTAHSRFPVIGEDKDEVLGILHAKDLLKYMFNP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a973RDAMITRSRMNVLKENDSIERITAYVIDTAHSRFPVIGEDKDEVLGILHAKDLLKYMFNP        70        80        90       100       110       120       130       140       150       160       170       180 m973.pepEQFHLKSILRPAVFVPEGKSLTALLKEFREQRNHMAIVIDEYGGTSGLVTFEDIIEQIVG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a973EQFHLKSILRPAVFVPEGKSLTALLKEFREQRNHMAIVIDEYGGISGLVTFEDIIEQIVG       130       140       150       160       170       180       190       200       210       220       230       240 m973.pepEIEDEFDEDDSADNIHAVSSERWRIHAATEIEDINTFFGTEYSXEEADTIGGLVIQELGH:||||||||:|||||||||:|||||||||||||||:||||||| |||||||||||||||| a973DIEDEFDEDESADNIHAVSAERWRIHAATEIEDINAFFGTEYSSEEADTIGGLVIQELGH       190       200       210       220       230       240       250       260       270 m973.pepLPVRGEKVLIGGLQFTVARADNRRLHTLMATRVKX |||||||||||||||||||||||||||||||||||a973 LPVRGEKVLIGGLQFTVARADNRRLHTLMATRVKX        250       260       270The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2955>:

g981.seq 1 ATGAAAAAAT GGATTGCCGC CGCCCTTGCC TGTTCCGCAC TCGCGCTGTC 51TGCCTGCGGC GGTCAGGGCA AAGATGCCGC CGCGCCTGCC GCCAACCCCG 101 GCAAAGTGTACCGCGTGGCT TCCAACGCCG AGTTTGCCCC CTTTGAATCT 151 TTAGACTCGA AAGGCAATGTCGAAGGTTTC GACGTGGATT TGATGAACGC 201 GATGGCGAAG GCGGGCAATT TTAAAATCGAATTCAAACAC CAGCCGTGGG 251 ACAGCCTTTT CCCCGCCTTG AACAACGGCG ATGCGGACGTTGTGATGTCG 301 GGCGTAACCA TTACCGACGA CCGCAAACAG TCTATGGATT TCAGCGACCC351 GTATTTTGAA ATCACCCAAG TCGTCCTCGT TCCGAAAGGC AAAAAAGTAT 401CTTCTTCCGA AGATTTGAAA AAGATGAACA AAGTCGGCGT GGTTACCGGC 451 CACACGGGCGATTTCTCCGT TTCCAAACTC TTGGGCAACG ACAATCCGAA 501 AATCGCGCGC TTCGAAAACGTCCCCCTGAT TATCAAAGAA CTGGAAAACG 551 GCGGCTTGGA TTCCGTGGTC AGCGACAGCGCGGTCATCGC CAATTATGTG 601 AAAAACAACC CGGCCAAAGG AATGGACTTC GTTACCCTGCCCGACTTCAC 651 CACCGAACAC TACGGCATCG CGGTACGCAA AGGCGACGAA GCAACCGTCA701 AAATGCTGAA CGATGCGTTG GAAAAAGTAC GCGAAAGCGG CGAATACGAC 751AAGATCTACG CCAAATATTT TGCCAAAGAG GGCGGACAGG CTGCGAAATA 801 AThis corresponds to the amino acid sequence <SEQ ID 2956; ORF 981.ng>:

g981.pep 1 MKKWIAAALA CSALALSACG GQGKDAAAPA ANPGKVYRVA SNAEFAPFES 51LDSKGNVEGF DVDLMNAMAK AGNFKIEFKH QPWDSLFPAL NNGDADVVMS 101 GVTITDDRKQSMDFSDPYFE ITQVVLVPKG KKVSSSEDLK KMNKVGVVTG 151 HTGDFSVSKL LGNDNPKIARFENVPLIIKE LENGGLDSVV SDSAVIANYV 201 KNNPAKGMDF VTLPDFTTEH YGIAVRKGDEATVKMLNDAL EKVRESGEYD 251 KIYAKYFAKE GGQAAK*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2957>:

m981.seq 1 ATGAAAAAAT GGATTGCCGC CGCCCTTGCC TGTTCCGCGC TCGCGCTGTC 51TGCCTGCGGC GGTCAGGGCA AAGATACCGC CGCGCCTGCC GCCAACCCCG 101 ACAAAGTGTACCGCGTGGCT TCCAACGCCG AGTTTGCCCC CTTTGAATCT 151 TTAGACTCGA AAGGCAATGTCGAAGGTTTC GATGTGGATT TGATGAACGC 201 GATGGCGAAG GCGGGCAATT TTAAAATCGAATTCAAACAC CAGCCGTGGG 251 ACAGCCTTTT CCCCGCCTTA AACAACGGCG ATGCGGACGTTGTGATGTCG 301 GGCGTAACCA TTACCGACGA CCGCAAACAG TCTATGGACT TCAGCGACCC351 GTATTTTGAA ATCACCCAAG TCGTCCTCGT TCCGAAAGGC AAAAAAGTAT 401CTTCTTCCGA AGATTTGAAA AACATGAACA AAGTCGGCGT GGTAACCGGC 451 TACACGGGCGATTTCTCCGT ATCCAAACTC TTGGGCAACG ACAATCCGAA 501 AATCGCGCGC TTTGAAAACGTTCCCCTGAT TATCAAAGAA CTGGAAAACG 551 GCGGCTTGGA TTCCGTGGTC AGCGACAGCGCGGTCATCGC CAATTATGTG 601 AAAAACAATC CGGCCAAAGG GATGGACTTC GTTACCCTGCCCGACTTCAC 651 CACCGAACAC TACGGCATCG CGGTACGCAA AGGCGACGAA GCAACCGTCA701 AAATGCTGAA CGATGCGTTG GAAAAAGTAC GCGAAAGCGG CGAATACGAC 751AAGATTTACG CCAAATATTT TGCAAAAGAA GACGGACAGG CCGCAAAATA 801 AThis corresponds to the amino acid sequence <SEQ ID 2958; ORF 981>:

m981.pep 1 MKKWIAAALA CSALALSACG GQGKDTAAPA ANPDKVYRVA SNAEFAPFES 51LDSKGNVEGF DVDLMNAMAK AGNFKIEFKH QPWDSLFPAL NNGDADVVMS 101 GVTITDDRKQSMDFSDPYFE ITQVVLVPKG KKVSSSEDLK NMNKVGVVTG 151 YTGDFSVSKL LGNDNPKIARFENVPLIIKE LENGGLDSVV SDSAVIANYV 201 KNNPAKGMDF VTLPDFTTEH YGIAVRKGDEATVKMLNDAL EKVRESGEYD 251 KIYAKYFAKE DGQAAK* m981/g981 98.1% identity in266 aa overlap        10        20        30        40        50        60 981.pepMKKWIAAALACSALALSACGGQGKDTAAPAANPDKVYRVASNAEFAPFESLDSKGNVEGF|||||||||||||||||||||||||:||||||| |||||||||||||||||||||||||| g981MKKWIAAALACSALALSACGGQGKDAAAPAANPGKVYRVASNAEFAPFESLDSKGNVEGF        10        20        30        40        50        60        70        80        90       100       110       120 981.pepDVDLMNAMAKAGNFKIEFKHQPWDSLFPALNNGDADVVMSGVTITDDRKQSMDFSDPYFE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g981DVDLMNAMAKAGNFKIEFKHQPWDSLFPALNNGDADVVMSGVTITDDRKQSMDFSDPYFE        70        80        90       100       110       120       130       140       150       160       170       180 981.pepITQVVLVPKGKKVSSSEDLKNMNKVGVVTGYTGDFSVSKLLGNDNPKIARFENVPLIIKE||||||||||||||||||||:|||||||||:||||||||||||||||||||||||||||| g981ITQVVLVPKGKKVSSSEDLKKMNKVGVVTGHTGDFSVSKLLGNDNPKIARFENVPLIIKE       130       140       150       160       170       180       190       200       210       220       230       240 981.pepLENGGLDSVVSDSAVIANYVKNNPAKGMDFVTLPDFTTEHYGIAVRKGDEATVKMLNDAL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g981LENGGLDSVVSDSAVIANYVKNNPAKGMDFVTLPDFTTEHYGIAVRKGDEATVKMLNDAL       190       200       210       220       230       240       250       260 981.pep EKVRESGEYDKIYAKYFAKEDGQAAKX|||||||||||||||||||| |||||| g981 EKVRESGEYDKIYAKYFAKEGGQAAKX       250       260The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2959>:

a981.seq 1 ATGAAAAAAT GGATTGCCGC CGCCCTTGCC TGTTCCGCGC TCGCGCTGTC 51TGCCTGCGGC GGTCAGGGTA AAGATGCCGC CGCGCCCGCC GCAAATCCCG 101 ACAAAGTGTACCGCGTGGCT TCCAACGCCG AGTTTGCCCC CTTTGAATCT 151 TTAGACTCGA AAGGCAATGTCGAAGGTTTC GATGTGGATT TGATGAACGC 201 GATGGCGAAG GCGGGCAATT TTAAAATCGAATTCAAACAC CAGCCGTGGG 251 ACAGCCTTTT CCCCGCCTTG AACAACGGCG ATGCGGACGTTGTGATGTCG 301 GGCGTAACCA TTACCGACGA CCGCAAACAG TCTATGGACT TCAGCGACCC351 GTATTTTGAA ATCACCCAAG TCGTCCTCGT TCCGAAAGGC AAAAAAATAT 401CTTCTTCCGA AGATTTGAAA AACATGAACA AAGTCGGCGT GGTAACCGGC 451 TACACGGGCGATTTCTCCGT ATCCAAACTC TTGGGCAACG ACAACCCGAA 501 AATCGCGCGC TTTGAAAACGTTCCCCTGAT TATCAAAGAA CTGGAAAACG 551 GCGGCTTGGA TTCCGTGGTC AGCGACAGCGCAGTCATCGC CAATTATGTG 601 AAAAACAATC CGACCAAAGG GATGGACTTC GTTACCCTGCCCGACTTCAC 651 CACCGAACAC TACGGCATCG CGGTACGCAA AGGCGACGAA GCAACCGTCA701 AAATGCTGAA CGATGCGTTG AAAAAAGTAC GCGAAAGCGG CGAATACGAC 751AAAATCTACG CCAAATATTT TGCAAAAGAA GACGGACAGG CCGCAAAATA 801 AThis corresponds to the amino acid sequence <SEQ ID 2960; ORF 981.a>:

a981.pep 1 MKKWIAAALA CSALALSACG GQGKDAAAPA ANPDKVYRVA SNAEFAPFES 51LDSKGNVEGF DVDLMNAMAK AGNFKIEFKH QPWDSLFPAL NNGDADVVMS 101 GVTITDDRKQSMDFSDPYFE ITQVVLVPKG KKISSSEDLK NMNKVGVVTG 151 YTGDFSVSKL LGNDNPKIARFENVPLIIKE LENGGLDSVV SDSAVIANYV 201 KNNPTKGMDF VTLPDFTTEH YGIAVRKGDEATVKMLNDAL KKVRESGEYD 251 KIYAKYFAKE DGQAAK* m981/a981 98.5% identity in266 aa overlap        10        20        30        40        50        60 m981.pepMKKWIAAALACSALALSACGGQGKDTAAPAANPDKVYRVASNAEFAPFESLDSKGNVEGF|||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||| a981MKKWIAAALACSALALSACGGQGKDAAAPAANPDKVYRVASNAEFAPFESLDSKGNVEGF        10        20        30        40        50        60        70        80        90       100       110       120 m981.pepDVDLMNAMAKAGNFKIEFKHQPWDSLFPALNNGDADVVMSGVTITDDRKQSMDFSDPYFE|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a981DVDLMNAMAKAGNFKIEFKHQPWDSLFPALNNGDADVVMSGVTITDDRKQSMDFSDPYFE        70        80        90       100       110       120       130       140       150       160       170       180 m981.pepITQVVLVPKGKKVSSSEDLKNMNKVGVVTGYTGDFSVSKLLGNDNPKIARFENVPLIIKE||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||| a981ITQVVLVPKGKKISSSEDLKNMNKVGVVTGYTGDFSVSKLLGNDNPKIARFENVPLIIKE       130       140       150       160       170       180       190       200       210       220       230       240 m981.pepLENGGLDSVVSDSAVIANYVKNNPAKGMDFVTLPDFTTEHYGIAVRKGDEATVKMLNDAL||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||| a981LENGGLDSVVSDSAVIANYVKNNPTKGMDFVTLPDFTTEHYGIAVRKGDEATVKMLNDAL       190       200       210       220       230       240       250       260 m981.pep EKVRESGEYDKIYAKYFAKEDGQAAKX:|||||||||||||||||||||||||| a981 KKVRESGEYDKIYAKYFAKEDGQAAKX       250       260The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2961>:

g982.seq 1 atcgcatcgc aaaaccttcg attcgacaat cgattcctcc aaaaaatggt 51caacggcgTg aatattttgc cggccgcCga ttgggtagcC ttgGGcgcCA 101 AAGGCCGCAACGTGGTGGTT GACCGCGCTT TCGGCGGCCC GCACATCACC 151 AAAGACGGCG TAACCGTCGCCAAAGAAATC GAACTGAAAG ACAAGTTTGA 201 AAATATGGGC GCGCAAATGG TAAAAGAAGTCGCGTCCAAA ACCAAcgaCg 251 tagCCGgcga cggtacgact accgCCACCG TATTGGCACAATCCATCGTT 301 GCCGAAggcA TGAAATACGT TACCGCCGGC ATGAACCCGA CCGATCTGAA351 ACGCGGCATC GACAAAGccg ttgCCGCTtt ggttgAAGAg cTGAAAAACA 401TCGCCAAACC TTGCGATACT TCCAAAGAAA TCGCCCAAGT CGGCTCGATT 451 TCCGCCAACTCCGACGAACA AGtcgGCGCG ATTATCGCCG AAGCGATGGA 501 AAAAGTCGGC AAAGAAGgcgtgattacCGT TGAAGACGGC AAATCTTTGG 551 AAAACGAGCT GGACGTGGTT GAAGGTATGCAGTTCGACCG CGGCTACCTG 601 TCCCCTTACT TTATCAACGA CGCGGAAAAA CAAATCGCCGGTCTGGACAA 651 TCCGTTTGTT TTGCTGTTCG ACAAAAAAAT CAGCAACATC CGCGACCTGC701 TGCCCGTGTT GGAACAAGTG GCGAAAGCCA GCCGCCCGCT GTTGATTATC 751GCTGAAGACG TAGAAGGCGA AGCCTTGGCG ACTTTGGTCG TGAACAACAT 801 CCGCGGCATCCTGAAAACCG TTGCCGTCAA AGCccccggc tTCGGcGACC 851 GCCGCAAAGC GATgctgcaagaCATCGCCA TCCTGACcgg cggcgTagtG 901 ATTtccGAAG Aagtcggcct GTCTTTGGAAAAAgcgactT TGgacgaCTT 951 Gggtcaaacc aaACGcatCG AAATCGGtga agaaaacactACCGTCATcg 1001 acgGCTTCGG CGACGcagcC CAAAtcgaag cgCGTGTTGC CGAAATCCGC1051 CAACAAATCG AAACCGCGAC CAGCGATTAC GACAAAGAAA AACTGCAAGA 1101GCGCGTTGCC AAACTGGCAG GAGGCGTGGC AGTGATCAAA GTCGGCGCGG 1151 CGACCGAAGTCGAAATGAAA GAGAAAAAAG ACCGCGTGGA AGACGCGCTG 1201 CACGCTACCC GCGCAGCCGTTGAAGAAGGC GTGGTTGCAG GCGGCGGCGT 1251 AGCCCTGTTG CGCGCCCGTG CCGCTTTGGAAAACCTGCAC ACCGGCAATG 1301 CCGACCAAGA CGCAGGCGTA CAAATCGTAT TGCGCGCCGTTGAGTCTCCG 1351 CTGCGCCAAA TCGTTGCCAA CGCAGGCGGA GAACCCAGCG TGGTGGTGAA1401 CAAAGTGTTG GAAGGCAAAG GCAactacgG TTACAACGCa ggctcCGGCG 1451AATACGgcga CATGATCGGA ATGGGCGTAC TCGACCCTGC CAAAGTAACC 1501 CGTTCCGCGCTGCAACACGC CGCGTCTAtC GCCGGTCTGA TGCTGACGAC 1551 CGACTGCATG ATTGCCGAAATCCCTGAAGA AAAACCGGCT GTGCCCGATA 1601 TGGGGGGAAT GGGCGGTATG GGCGGCATGATGTAAThis corresponds to the amino acid sequence <SEQ ID 2962; ORF 982.ng>:

g982.pep 1 IASQNLRFDN RFLQKMVNGV NILPAADWVA LGAKGRNVVV DRAFGGPHIT 51KDGVTVAKEI ELKDKFENMG AQMVKEVASK TNDVAGDGTT TATVLAQSIV 101 AEGMKYVTAGMNPTDLKRGI DKAVAALVEE LKNIAKPCDT SKEIAQVGSI 151 SANSDEQVGA IIAEAMEKVGKEGVITVEDG KSLENELDVV EGMQFDRGYL 201 SPYFINDAEK QIAGLDNPFV LLFDKKISNIRDLLPVLEQV AKASRPLLII 251 AEDVEGEALA TLVVNNIRGI LKTVAVKAPG FGDRRKAMLQDIAILTGGVV 301 ISEEVGLSLE KATLDDLGQT KRIEIGEENT TVIDGFGDAA QIEARVAEIR351 QQIETATSDY DKEKLQERVA KLAGGVAVIK VGAATEVEMK EKKDRVEDAL 401HATRAAVEEG VVAGGGVALL RARAALENLH TGNADQDAGV QIVLRAVESP 451 LRQIVANAGGEPSVVVNKVL EGKGNYGYNA GSGEYGDMIG MGVLDPAKVT 501 RSALQHAASI AGLMLTTDCMIAEIPEEKPA VPDMGGMGGM GGMM*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2963>:

m982.seq 1 ATGGCAGCAA AAGACGTACA GTTCGGCAAT GAAGTCCGTC AAAAAATGGT 51AAACGGCGTG AACATTCTGG CAAACGCCGT CCGCGTAACC TTGGGCCCCA 101 AAGGTCGCAACGTAGTCGTT GACCGCGCAT TCGGCGGCCC GCACATCACC 151 AAAGACGGCG TAACCGTCGCCAAAGAAATC GAACTGAAAG ACAAGTTTGA 201 AAATATGGGC GCGCAAATGG TGAAAGAAGTTGCGTCCAAA ACCAACGACG 251 TGGCAGGCGA CGGTACGACT ACCGCCACCG TACTGGCGCAATCCATCGTT 301 GCCGAAGGTA TGAAATATGT TACCGCAGGT ATGAATCCGA CCGACCTGAA351 ACGCGGTATC GATAAAGCCG TCGCCGCTTT GGTTGACGAA CTGAAAAACA 401TCGCCAAACC TTGCGACACT TCTAAAGAAA TCGCCCAAGT CGGCTCTATT 451 TCCGCCAACTCCGACGAACA AGTCGGCGCG ATTATCGCCG AAGCGATGGA 501 AAAAGTCGGC AAAGAAGGCGTGATTACCGT TGAAGACGGC AAGTCTTTGG 551 AAAACGAGCT GGACGTAGTT GAAGGTATGCAGTTCGACCG CGGCTACCTG 601 TCTCCTTACT TCATCAACGA TGCGGAAAAA CAAATCGCTGCTTTGGACAA 651 TCCGTTTGTA TTGTTGTTCG ACAAAAAAAT CAGCAACATC CGCGACCTGC701 TGCCTGTTTT GGAACAAGTG GCAAAAGCCA GCCGTCCGCT GTTGATTATC 751GCTGAAGACG TAGAAGGCGA AGCCTTGGCG ACTTTGGTCG TGAACAACAT 801 CCGAGGCATCCTGAAAACCG TTGCCGTCAA AGCCCCTGGC TTCGGCGACC 851 GCCGCAAAGC GATGTTGCAAGACATCGCCA TCCTGACCGG CGGCGTGGTG 901 ATTTCCGAAG AAGTCGGTCT GTCTTTGGAAAAAGCGACTT TGGACGACTT 951 GGGTCAAGCC AAACGCATCG AAATCGGTAA AGAAAACACCACCATCATCG 1001 ACGGCTTTGG CGACGCAGCC CAAATCGAAG CGCGTGTTGC CGAAATCCGC1051 CAACAAATCG AAACCGCAAC CAGCGATTAC GACAAAGAAA AACTGCAAGA 1101GCGCGTGGCT AAATTGGCAG GCGGCGTGGC AGTCATCAAA GTCGGTGCCG 1151 CGACCGAAGTCGAAATGAAA GAGAAAAAAG ACCGCGTGGA AGACGCGCTG 1201 CACGCTACCC GCGCAGCCGTTGAAGAAGGC GTGGTTGCAG GCGGCGGCGT 1251 AGCCCTGTTG CGTGCCCGTG CTGCTTTGGAAAACCTGCAC ACCGGCAATG 1301 CCGACCAAGA CGCAGGCGTA CAAATCGTCT TGCGCGCCGTTGAGTCTCCG 1351 CTGCGCCAAA TCGTTGCCAA CGCAGGCGGC GAACCCAGCG TGGTTGTGAA1401 CAAAGTATTG GAAGGCAAAG GCAACTACGG TTACAACGCT GGCAGCGGCG 1451AATACGGCGA TATGATCGAA ATGGGCGTAC TCGACCCCGC CAAAGTAACC 1501 CGTTCTGCGCTGCAACACGC CGCATCTATC GCCGGCTTGA TGCTGACCAC 1551 TGATTGCATG ATCGCTGAAATCCCCGAAGA CAAACCGGCT GTGCCTGATA 1601 TGGGCGGCAT GGGTGGTATG GGCGGCATGATGTAAThis corresponds to the amino acid sequence <SEQ ID 2964; ORF 982>:

m982.seq 1 ATGGCAGCAA AAGACGTACA GTTCGGCAAT GAAGTCCGTC AAAAAATGGT 51AAACGGCGTG AACATTCTGG CAAACGCCGT CCGCGTAACC TTGGGCCCCA 101 AAGGTCGCAACGTAGTCGTT GACCGCGCAT TCGGCGGCCC GCACATCACC 151 AAAGACGGCG TAACCGTCGCCAAAGAAATC GAACTGAAAG ACAAGTTTGA 201 AAATATGGGC GCGCAAATGG TGAAAGAAGTTGCGTCCAAA ACCAACGACG 251 TGGCAGGCGA CGGTACGACT ACCGCCACCG TACTGGCGCAATCCATCGTT 301 GCCGAAGGTA TGAAATATGT TACCGCAGGT ATGAATCCGA CCGACCTGAA351 ACGCGGTATC GATAAAGCCG TCGCCGCTTT GGTTGACGAA CTGAAAAACA 401TCGCCAAACC TTGCGACACT TCTAAAGAAA TCGCCCAAGT CGGCTCTATT 451 TCCGCCAACTCCGACGAACA AGTCGGCGCG ATTATCGCCG AAGCGATGGA 501 AAAAGTCGGC AAAGAAGGCGTGATTACCGT TGAAGACGGC AAGTCTTTGG 551 AAAACGAGCT GGACGTAGTT GAAGGTATGCAGTTCGACCG CGGCTACCTG 601 TCTCCTTACT TCATCAACGA TGCGGAAAAA CAAATCGCTGCTTTGGACAA 651 TCCGTTTGTA TTGTTGTTCG ACAAAAAAAT CAGCAACATC CGCGACCTGC701 TGCCTGTTTT GGAACAAGTG GCAAAAGCCA GCCGTCCGCT GTTGATTATC 751GCTGAAGACG TAGAAGGCGA AGCCTTGGCG ACTTTGGTCG TGAACAACAT 801 CCGAGGCATCCTGAAAACCG TTGCCGTCAA AGCCCCTGGC TTCGGCGACC 851 GCCGCAAAGC GATGTTGCAAGACATCGCCA TCCTGACCGG CGGCGTGGTG 901 ATTTCCGAAG AAGTCGGTCT GTCTTTGGAAAAAGCGACTT TGGACGACTT 951 GGGTCAAGCC AAACGCATCG AAATCGGTAA AGAAAACACCACCATCATCG 1001 ACGGCTTTGG CGACGCAGCC CAAATCGAAG CGCGTGTTGC CGAAATCCGC1051 CAACAAATCG AAACCGCAAC CAGCGATTAC GACAAAGAAA AACTGCAAGA 1101GCGCGTGGCT AAATTGGCAG GCGGCGTGGC AGTCATCAAA GTCGGTGCCG 1151 CGACCGAAGTCGAAATGAAA GAGAAAAAAG ACCGCGTGGA AGACGCGCTG 1201 CACGCTACCC GCGCAGCCGTTGAAGAAGGC GTGGTTGCAG GCGGCGGCGT 1251 AGCCCTGTTG CGTGCCCGTG CTGCTTTGGAAAACCTGCAC ACCGGCAATG 1301 CCGACCAAGA CGCAGGCGTA CAAATCGTCT TGCGCGCCGTTGAGTCTCCG 1351 CTGCGCCAAA TCGTTGCCAA CGCAGGCGGC GAACCCAGCG TGGTTGTGAA1401 CAAAGTATTG GAAGGCAAAG GCAACTACGG TTACAACGCT GGCAGCGGCG 1451AATACGGCGA TATGATCGAA ATGGGCGTAC TCGACCCCGC CAAAGTAACC 1501 CGTTCTGCGCTGCAACACGC CGCATCTATC GCCGGCTTGA TGCTGACCAC 1551 TGATTGCATG ATCGCTGAAATCCCCGAAGA CAAACCGGCT GTGCCTGATA 1601 TGGGCGGCAT GGGTGGTATG GGCGGCATGATGTAAComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m982/g982 95.8% identity in 544 aa overlap        10        20        30        40        50        60 m982.pepMAAKDVQFGNEVRQKMVNGVNILANAVRVTLGPKGRNVVVDRAFGGPHITKDGVTVAKEI :|:::::| |:  ||||||||||  |  |:|| ||||||||||||||||||||||||||| g982IASQNLRFDNRFLQKMVNGVNILPAADWVALGAKGRNVVVDRAFGGPHITKDGVTVAKEI        10        20        30        40        50        60        70        80        90       100       110       120 m982.pepELKDKFENMGAQMVKEVASKTNDVAGDGTTTATVLAQSIVAEGMKYVTAGMNPTDLKRGI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g982ELKDKFENMGAQMVKEVASKTNDVAGDGTTTATVLAQSIVAEGMKYVTAGMNPTDLKRGI        70        80        90       100       110       120       130       140       150       160       170       180 m982.pepDKAVAALVDELKNIAKPCDTSKEIAQVGSISANSDEQVGAIIAEAMEKVGKEGVITVEDG||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||| g982DKAVAALVEELKNIAKPCDTSKEIAQVGSISANSDEQVGAIIAEAMEKVGKEGVITVEDG       130       140       150       160       170       180       190       200       210       220       230       240 m982.pepKSLENELDVVEGMQFDRGYLSPYFINDAEKQIAALDNPFVLLFDKKISNIRDLLPVLEQV|||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||| g982KSLENELDVVEGMQFDRGYLSPYFINDAEKQIAGLDNPFVLLFDKKISNIRDLLPVLEQV       190       200       210       220       230       240       250       260       270       280       290       300 m982.pepAKASRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLQDIAILTGGVV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g982AKASRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLQDIAILTGGVV       250       260       270       280       290       300       310       320       330       340       350       360 m982.pepISEEVGLSLEKATLDDLGQAKRIEIGKENTTIIDGFGDAAQIEARVAEIRQQIETATSDY|||||||||||||||||||:||||||:||||:|||||||||||||||||||||||||||| g982ISEEVGLSLEKAILDDLGQTKRIEIGEENTIVIDGFGDAAQIEARVAEIRQQIETATSDY       310       320       330       340       350       360       370       380       390       400       410       420 m982.pepDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGVVAGGGVALL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g982DKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGVVAGGGVALL       370       380       390       400       410       420       430       440       450       460       470       480 m982.pepRARAALENLHTGNADQDAGVQIVLRAVESPLRQIVANAGGEPSVVVNKVLEGKGNYGYNA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g982RARAALENLHTGNADQDAGVQIVLRAVESPLRQIVANAGGEPSVVVNKVLEGKGNYGYNA       430       440       450       460       470       480       490       500       510       520       530       540 m982.pepGSGEYGDMIEMGVLDPAKVTRSALQHAASIAGLMLTTDCMIAEIPEDKPAVPDMGGMGGM||||||||| ||||||||||||||||||||||||||||||||||||:||||||||||||| g982GSGEYGDMIGMGVLDPAKVTRSALQHAASIAGLMLTTDCMIAEIPEEKPAVPDMGGMGGM       490       500       510       520       530       540 m982.pepGGMMX ||||| g982 GGMMXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 2965>:

a982.seq 1 ATGGCAGCAA AAGACGTACA ATTCGGCAAT GAAGTCCGCC AAAAAATGGT 51AAACGGCGTG AACATTTTGG CAAACGCCGT GCGCGTAACC TTGGGTCCCA 101 AAGGCCGCAACGTGGTGGTT GACCGCGCTT TCGGCGGCCC GCACATCACC 151 AAAGACGGCG TAACCGTCGCCAAAGAAATC GAACTGAAAG ACAAGTTTGA 201 AAATATGGGC GCGCAAATGG TGAAAGAAGTCGCGTCCAAA ACCAACGACG 251 TGGCGGGCGA CGGTACGACT ACCGCCACCG TATTGGCGCAATCCATCGTT 301 GCCGAAGGTA TGAAATACGT TACCGCCGGT ATGAACCCGA CCGACCTGAA351 ACGCGGTATC GACAAAGCCG TCGCCGCTTT GGTTGAAGAG CTGAAAAACA 401TCGCCAAACC TTGCGACACT TCTAAAGAAA TCGCCCAAGT CGGCTCTATT 451 TCCGCCAACTCTGACGAACA AGTCGGCGCG ATTATTGCCG AAGCGATGGA 501 AAAAGTCGGC AAAGAAGGCGTGATTACCGT TGAAGACGGC AAATCTTTGG 551 AAAACGAGCT GGACGTGGTT GAAGGTATGCAATTCGACCG CGGCTACCTG 601 TCTCCTTACT TCATCAACGA TGCGGAAAAA CAAATCGCCGGCTTGGACAA 651 TCCGTTTGTA TTGCTGTTCG ACAAAAAAAT CAGCAATATC CGCGACCTGC701 TGCCTGTTTT GGAACAAGTG GCCAAAGCCA GCCGTCCGCT GTTGATTATC 751GCTGAAGACG TAGAAGGCGA AGCCTTGGCG ACTTTGGTCG TGAACAACAT 801 CCGCGGCATTCTGAAAACCG TTGCCGTTAA AGCTCCGGGC TTCGGCGACC 851 GCCGCAAAGC GATGCTGCAAGACATCGCTA TCCTGACCGG CGGCACAGTG 901 ATTTCCGAAG AAGTCGGCCT GTCTTTGGAAAAAGCGACTT TGGACGACTT 951 GGGTCAGGCC AAACGCATCG AAATCGGTAA AGAAAACACCACCATCATCG 1001 ACGGCTTCGG CGACGCAGCC CAAATCGAAG CGCGTGTTGC CGAAATCCGC1051 CAACAAATCG AAACCGCAAC CAGCGATTAC GACAAAGAAA AACTGCAAGA 1101GCGCGTTGCC AAACTGGCAG GCGGCGTGGC AGTAATCAAA GTCGGTGCCG 1151 CGACCGAAGTGGAAATGAAA GAGAAAAAAG ACCGCGTGGA AGACGCGCTG 1201 CACGCTACCC GCGCAGCCGTTGAAGAAGGC GTGGTTGCAG GCGGCGGCGT 1251 AGCCCTGTTG CGCGCCCGTG CCGCTCTGGAAAACCTGCAC ACCGGCAATG 1301 CAGACCAAGA CGCAGGCGTA CAAATCGTCT TGCGCGCCGTTGAGTCTCCG 1351 CTGCGCCAAA TCGTTGCCAA CGCAGGCGGC GAACCCAGCG TGGTTGTGAA1401 CAAAGTGTTG GAAGGCAAAG GCAACTATGG TTACAACGCT GGCAGCGGCG 1451AATACGGCGA CATGATCGAA ATGGGCGTAC TCGACCCCGC CAAAGTAACC 1501 CGTTCCGCGCTGCAACACGC CGCGTCTATC GCCGGCCTGA TGCTGACCAC 1551 AGACTGCATG ATTGCTGAAATCCCTGAAGA CAAACCGGCT ATGCCTGATA 1601 TGGGCGGCAT GGGTGGTATG GGCGGCATGATGTAAThis corresponds to the amino acid sequence <SEQ ID 2966; ORF 982.a>:

a982.pep 1 MAAKDVQFGN EVRQKMVNGV NILANAVRVT LGPKGRNVVV DRAFGGPHIT 51KDGVTVAKEI ELKDKFENMG AQMVKEVASK TNDVAGDGTT TATVLAQSIV 101 AEGMKYVTAGMNPTDLKRGI DKAVAALVEE LKNIAKPCDT SKEIAQVGSI 151 SANSDEQVGA IIAEAMEKVGKEGVITVEDG KSLENELDVV EGMQFDRGYL 201 SPYFINDAEK QIAGLDNPFV LLFDKKISNIRDLLPVLEQV AKASRPLLII 251 AEDVEGEALA TLVVNNIRGI LKTVAVKAPG FGDRRKAMLQDIAILTGGTV 301 ISEEVGLSLE KATLDDLGQA KRIEIGKENT TIIDGFGDAA QIEARVAEIR351 QQIETATSDY DKEKLQERVA KLAGGVAVIK VGAATEVEMK EKKDRVEDAL 401HATRAAVEEG VVAGGGVALL RARAALENLH TGNADQDAGV QIVLRAVESP 451 LRQIVANAGGEPSVVVNKVL EGKGNYGYNA GSGEYGDMIE MGVLDPAKVT 501 RSALQHAASI AGLMLTTDCMIAEIPEDKPA MPDMGGMGGM GGMM* m982/a982 99.3% identity in 544 aa overlap        10        20        30        40        50        60 m982.pepMAAKDVQFGNEVRQKMVNGVNILANAVRVTLGPKGRNVVVDRAFGGPHITKDGVTVAKEI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a982MAAKDVQFGNEVRQKMVNGVNILANAVRVTLGPKGRNVVVDRAFGGPHITKDGVTVAKEI        10        20        30        40        50        60        70        80        90       100       110       120 m982.pepELKDKFENMGAQMVKEVASKTNDVAGDGTTTATVLAQSIVAEGMKYVTAGMNPTDLKRGI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a982ELKDKFENMGAQMVKEVASKTNDVAGDGTTTATVLAQSIVAEGMKYVTAGMNPTDLKRGI        70        80        90       100       110       120       130       140       150       160       170       180 m982.pepDKAVAALVDELKNIAKPCDTSKEIAQVGSISANSDEQVGAIIAEAMEKVGKEGVITVEDG||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||| a982DKAVAALVEELKNIAKPCDTSKEIAQVGSISANSDEQVGAIIAEAMEKVGKEGVITVEDG       130       140       150       160       170       180       190       200       210       220       230       240 m982.pepKSLENELDVVEGMQFDRGYLSPYFINDAEKQIAALDNPFVLLFDKKISNIRDLLPVLEQV|||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||| a982KSLENELDVVEGMQFDRGYLSPYFINDAEKQIAGLDNPFVLLFDKKISNIRDLLPVLEQV       190       200       210       220       230       240       250       260       270       280       290       300 m982.pepAKASRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLQDIAILTGGVV||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:| a982AKASRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLQDIAILTGGTV       250       260       270       280       290       300       310       320       330       340       350       360 m982.pepISEEVGLSLEKATLDDLGQAKRIEIGKENTTIIDGFGDAAQIEARVAEIRQQIETATSDY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a982ISEEVGLSLEKAILDDLGQAKRIEIGKENTTIIDGFGDAAQIEARVAEIRQQIETATSDY       310       320       330       340       350       360       370       380       390       400       410       420 m982.pepDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGVVAGGGVALL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a982DKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGVVAGGGVALL       370       380       390       400       410       420       430       440       450       460       470       480 m982.pepRARAALENLHTGNADQDAGVQIVLRAVESPLRQIVANAGGEPSVVVNKVLEGKGNYGYNA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a982RARAALENLHTGNADQDAGVQIVLRAVESPLRQIVANAGGEPSVVVNKVLEGKGNYGYNA       430       440       450       460       470       480       490       500       510       520       530       540 m982.pepGSGEYGDMIEMGVLDPAKVTRSALQHAASIAGLMLTTDCMIAEIPEDKPAVPDMGGMGGM||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||| a982GSGEYGDMIEMGVLDPAKVTRSALQHAASIAGLMLTTDCMIAEIPEDKPAMPDMGGMGGM       490       500       510       520       530       540 m982.pepGGMMX ||||| a982 GGMMXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2967>:

g986.seq 1 GTGTTCAAAA AATACCAATA CTTCGCTTTG GCGGCACTGT GTGCCGCCTT 51GCTGGCAGGC TGCGAAAAGG CAGGCAGCTT TTTCGGTGCG GACAAAAAAG 101 AAGCATCCTTCGTAGAACGC ATCGAACACA CCAAAGACGA CGGCAGTGTC 151 AGTATGCTGC TGCCCGACTTTGCCCAACTG GTTCAAAGCG AAGGCCCGGC 201 AGTCGTCAAT ATTCAGGCAG CCCCCGCCCCGCGCACCCAA AACGGCAGCG 251 GCAATGCCGA AACCGATTCC GACCCGCTTG CCGACAGCGACCCGTTCTAC 301 GAATTTTTCA AACGCCTCGT CCCGAACATG CCCGAAATCC CCCAAGAAGA351 AGCAGATGAC GGCGGATTGA ACTTCGGTTC GGGCTTCATC ATCAGCAAAA 401ACGGCTACAT CCTGACCAAT ACCCACGTCG TTGCCGGTAT GGGCAGTATC 451 AAAGTCCTGCTCAACGACAA GCGCGAATAT ACCGCCAAAC TCATCGGTTC 501 GGATGTCCAA TCCGATGTCGCCCTTCTGAA AATCGACGCA ACGGAAGAGC 551 TACCCGTCGT CAAAATCGGC AATCCCAAAAATTTGAAACC GGGCGAATGG 601 GTCGCTGCCA TCGGCGCGCC CTTCGGCTTT GACAACAGCGTGACCGCCGG 651 CATCGTGTCC GCCAAAGGCA GAAGCCTGCC CAACGAAAgc tACACACCCT701 TCATCCAAAC CGACGTTGCC ATCAATCCGG GCAATTCCGG CGGCCCGCTG 751TTCAACTTAA AAGGACAGGt cgTCGGCATC AATTCGCAAA TATACAGCCG 801 CAGCGgcggattCATGGGCA TCTCCTTTGC CATCCCGATT GACGTTGCCA 851 TGAATGTCGC CGAACAGCTGAAAAACACCG GCAAAGTCCA ACGCGGACAA 901 CTGGGCGTGA TTATTCAGGA AGTATCCTACGGTTTGGCAC AGTCGTTCGG 951 TCTGGATAAA GCCAGCGGCG CATTGATTGC CAAAATCCTTCCCGGCAGCC 1001 CCGCAGAACG TGCCGGCCTG CAGGCGGGCG ACATCGTCCT CAGCCTCGAC1051 GGCGGAGAAA TACGTTCTTC CGGCGACCTT CCCGTCATGG TCGGCGCCAT 1101TACGCCGGGA AAAGAAGTCA GCCTCGGCGT ATGGCGCAAA GGCGAAGAAA 1151 TCACAATCAAAGCCAAGCTG GGCAACGCCg ccgagcATAC CGGCgcatCA 1201 TCCAAAACAG ATGAAgccccctacaccgAA CAGCAATCCG GTACGTTCTC 1251 GGTCGAATCC GCAGGCATTA CCCTTCAGACACATACCGAC AGCAGCGGca 1301 aacacctcgt cgtcgtacgg gtttccgacg cggcagaacgcGCAGGCTTA 1351 AGgcgcggcg acgaaatcct cgcggtcggg caagtccccg tcaatgacga1401 agccgGTTTC cgcaaaGCTA TGGACAAGGC AGGCAAAAAC GTCCCCCTGC 1451TGGTCAtgcg ccgTGGCAAC ACGCTGTTCA TCGCATTAAA CCTGCAATAAThis corresponds to the amino acid sequence <SEQ ID 2968; ORF 986.ng>:

g986.pep 1 VFKKYQYFAL AALCAALLAG CEKAGSFFGA DKKEASFVER IEHTKDDGSV 51SMLLPDFAQL VQSEGPAVVN IQAAPAPRTQ NGSGNAETDS DPLADSDPFY 101 EFFKRLVPNMPEIPQEEADD GGLNFGSGFI ISKNGYILTN THVVAGMGSI 151 KVLLNDKREY TAKLIGSDVQSDVALLKIDA TEELPVVKIG NPKNLKPGEW 201 VAAIGAPFGF DNSVTAGIVS AKGRSLPNESYTPFIQTDVA INPGNSGGPL 251 FNLKGQVVGI NSQIYSRSGG FMGISFAIPIDVAMNVAEQL KNTGKVQRGQ 301 LGVIIQEVSY GLAQSFGLDK ASGALIAKIL PGSPAERAGLQAGDIVLSLD 351 GGEIRSSGDL PVMVGAITPG KEVSLGVWRK GEEITIKAKL GNAAEHTGAS401 SKTDEAPYTE QQSGTFSVES AGITLQTHTD SSGKHLVVVR VSDAAERAGL 451RRGDEILAVG QVPVNDEAGF RKAMDKAGKN VPLLVMRRGN TLFIALNLQ*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2969>:

m986.seq 1 GTGTTCAAAA AATACCAATA CCTCGCTTTG GCAGCACTGT GTGCAGCCTC 51GCTGGCAGGC TGCGACAAGG CAGGCAGCTT CTTCGTGGCG GACAAAAAAG 101 AAGCATCCTTCGTAGAACGC ATCGAACACA CCAAAGACGA CGGCAGCGTC 151 AGTATGCTGC TGCCCGACTTTGCCCAACTG GTTCAAAGTG AAGGTCCGGC 201 AGTCGTCAAT ATTCAGGCAG CCCCCGCCCCGCGCACCCAA AACGGCAGCG 251 GCAATGCCGA AAACGATTCC GACCCGATTG CCGACAACGACCCGTTCTAC 301 GAATTTTTCA AACGCCTCGT CCCGAATATG CCCGAAATCC CCCAAGAAGA351 AGCAGATGAC GGCGGATTGA ACTTCGGTTC GGGCTTCATC ATCAGCAAAG 401ACGGCTACAT CCTGACCAAT ACCCACGTCG TTACCGGCAT GGGCAGTATC 451 AAAGTCCTGCTCAACGACAA GCGCGAATAT ACCGCCAAAC TCATCGGTTC 501 GGATGTCCAA TCCGATGTCGCCCTTCTGAA AATCGACGCA ACGGAAGAGC 551 TGCCCGTCGT CAAAATCGGC AATCCCAAAGATTTGAAACC GGGCGAATGG 601 GTCGCCGCCA TCGGCGCGCC CTTCGGCTTC GACAACAGCGTGACCGCCGG 651 CATCGTGTCC GCCAAAGGCA GAAGCCTGCC CAACGAAAGC TACACACCCT701 TCATCCAAAC CGACGTTGCC ATCAATCCGG GCAACTCCGG CGGCCCGCTG 751TTCAACTTAA AAGGACAGGT CGTCGGCATC AACTCGCAAA TATACAGCCG 801 CAGCGGCGGATTCATGGGCA TTTCCTTCGC CATCCCGATT GACGTTGCCA 851 TGAATGTCGC CGAACAGCTGAAAAACACCG GCAAAGTCCA ACGCGGACAA 901 CTGGGCGTGA TTATTCAAGA AGTATCCTACGGTTTGGCAC AATCGTTCGG 951 TTTGGACAAA GCCGGCGGCG CACTGATTGC CAAAATCCTGCCCGGCAGCC 1001 CCGCAGAACG TGCCGGCCTG CAGGCGGGCG ACATCGTCCT CAGCCTCGAC1051 GGCGGAGAAA TACGTTCTTC CGGCGACCTT CCCGTTATGG TCGGCGCCAT 1101TACGCCGGGA AAAGAAGTCA GCCTCGGCGT ATGGCGCAAA GGCGAAGAAA 1151 TCACAATCAAAGTCAAGCTG GGCAACGCCG CCGAGCATAT CGGCGCATCA 1201 TCCAAAACAG ATGAAGCCCCCTACACCGAA CAGCAATCCG GTACGTTCTC 1251 GGTCGAATCC GCAGGCATTA CCCTTCAGACACATACCGAC AGCAGCGGCG 1301 GACACCTCGT CGTCGTACGG GTTTCCGACG CGGCAGAACGCGCAGGCTTG 1351 AGGCGCGGCG ACGAAATTCT TGCCGTCGGG CAAGTCCCCG TCAATGACGA1401 AGCCGGTTTC CGCAAAGCTA TGGACAAGGC AGGCAAAAAC GTCCCCCTGC 1451TGATCATGCG CCGTGGCAAC ACGCTGTTTA TCGCATTAAA CCTGCAATAAThis corresponds to the amino acid sequence <SEQ ID 2970; ORF 986>:

m986.pep.. 1 VFKKYQYLAL AALCAASLAG CDKAGSFFVA DKKEASFVER IEHTKDDGSV 51SMLLPDFAQL VQSEGPAVVN IQAAPAPRTQ NGSGNAENDS DPIADNDPFY 101 EFFKRLVPNMPEIPQEEADD GGLNFGSGFI ISKDGYILTN THVVTGMGSI 151 KVLLNDKREY TAKLIGSDVQSDVALLKIDA TEELPVVKIG NPKDLKPGEW 201 VAAIGAPFGF DNSVTAGIVS AKGRSLPNESYTPFIQTDVA INPGNSGGPL 251 FNLKGQVVGI NSQIYSRSGG FMGISFAIPIDVAMNVAEQL KNTGKVQRGQ 301 LGVIIQEVSY GLAQSFGLDK AGGALIAKIL PGSPAERAGLQAGDIVLSLD 351 GGEIRSSGDL PVMVGAITPG KEVSLGVWRK GEEITIKVKL GNAAEHIGAS401 SKTDEAPYTE QQSGTFSVES AGITLQTHTD SSGGHLVVVR VSDAAERAGL 451RRGDEILAVG QVPVNDEAGF RKAMDKAGKN VPLLIMRRGN TLFIALNLQ*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m986/g986 97.0% identity in 499 aa overlap        10        20        30        40        50        60 m986.pepVFKKYQYLALAALCAASLAGCDKAGSFFVADKKEASFVERIEHTKDDGSVSMLLPDFAQL|||||||:|||||||| ||||:|||||| ||||||||||||||||||||||||||||||| g986VFKKYQYFALAALCAALLAGCEKAGSFFGADKKEASFVERIEHTKDDGSVSMLLPDFAQL        10        20        30        40        50        60        70        80        90       100       110       120 m986.pepVQSEGPAVVNIQAAPAPRTQNGSGNAENDSDPIADNDPFYEFFKRLVPNMPEIPQEEADD|||||||||||||||||||||||||||:||||:||:|||||||||||||||||||||||| g986VQSEGPAVVNIQAAPAPRTQNGSGNAETDSDPLADSDPFYEFFKRLVPNMPEIPQEEADD        70        80        90       100       110       120       130       140       150       160       170       180 m986.pepGGLNFGSGFIISKDGYILTNTHVVTGMGSIKVLLNDKREYTAKLIGSDVQSDVALLKIDA|||||||||||||:||||||||||:||||||||||||||||||||||||||||||||||| g986GGLNFGSGFIISKNGYILTNTHVVAGMGSIKVLLNDKREYTAKLIGSDVQSDVALLKIDA       130       140       150       160       170       180       190       200       210       220       230       240 m986.pepTEELPVVKIGNPKDLKPGEWVAAIGAPFGFDNSVTAGIVSAKGRSLPNESYTPFIQTDVA|||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||| g986TEELPVVKIGNPKNLKPGEWVAAIGAPFGFDNSVTAGIVSAKGRSLPNESYTPFIQTDVA       190       200       210       220       230       240       250       260       270       280       290       300 m986.pepINPGNSGGPLFNLKGQVVGINSQIYSRSGGFMGISFAIPIDVAMNVAEQLKNTGKVQRGQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g986INPGNSGGPLFNLKGQVVGINSQIYSRSGGFMGISFAIPIDVAMNVAEQLKNTGKVQRGQ       250       260       270       280       290       300       310       320       330       340       350       360 m986.pepLGVIIQEVSYGLAQSFGLDKAGGALIAKILPGSPAERAGLQAGDIVLSLDGGEIRSSGDL|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| g986LGVIIQEVSYGLAQSFGLDKASGALIAKILPGSPAERAGLQAGDIVLSLDGGEIRSSGDL       310       320       330       340       350       360       370       380       390       400       410       420 m986.pepPVMVGAITPGKEVSLGVWRKGEEITIKVKLGNAAEHIGASSKTDEAPYTEQQSGTFSVES|||||||||||||||||||||||||||:|||||||| ||||||||||||||||||||||| g986PVMVGAITPGKEVSLGVWRKGEEITIKAKLGNAAEHTGASSKTDEAPYTEQQSGTFSVES       370       380       390       400       410       420       430       440       450       460       470       480 m986.pepAGITLQTHTDSSGGHLVVVRVSDAAERAGLRRGDEILAVGQVPVNDEAGFRKAMDKAGKN||||||||||||| |||||||||||||||||||||||||||||||||||||||||||||| g986AGITLQTHTDSSGKHLVVVRVSDAAERAGLRRGDEILAVGQVPVNDEAGFRKAMDKAGKN       430       440       450       460       470       480       490       500 m986.pep VPLLIMRRGNTLFIALNLQX ||||:|||||||||||||||g986 VPLLIMRRGNTLFIALNLQX        490       500The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2971>:

a986.seq 1 GTGTTCAAAA AATACCAATA CCTCGCTTTG GCAGCACTGT GTGCCGCCTC 51GCTGGCAGGC TGCGACAAAG CCGGCAGCTT TTTCGGTGCG GACAAAAAAG 101 AAGCATCCTTTGTAGAACGC ATCAAACACA CCAAAGACGA CGGCAGCGTC 151 AGTATGCTGC TGCCCGACTTTGTCCAACTG GTTCAAAGCG AAGGCCCGGC 201 AGTCGTCAAT ATTCAGGCAG CCCCCGCCCCGCGCACCCAA AACGGCAGCA 251 GCAATGCCGA AACCGATTCC GACCCGCTTG CCGACAGCGACCCGTTCTAC 301 GAATTTTTCA AACGCCTCGT CCCGAACATG CCCGAAATCC CCCAAGAAGA351 AGCAGATGAC GGNGGATTGA ACTTCGGTTC GGGCTTCATC ATCAGCAAAG 401ACGGCTATAT TCTGACCAAT ACGCACGTCG TTACCGGCAT GGGCAGTATC 451 AAAGTCCTGCTCAACGACAA GCGCGAATAT ACCGCCAAAC TCATCGGTTC 501 GGATGTCCAA TCCGATGTCGCCCTTCTGAA AATCGACGCA ACGGAAGAGC 551 TGCCCGTCGT CAAAATCGGC AATCCCAAAGATTTGAAACC GGGCGAATGG 601 GTCGCCGCCA TCGGCGCGCC CTTCGGCTTC GACAACAGCGTGACCGCCGG 651 CNTCGTGTCC GCCAAAGGCA GAAGCCTGCC CAACGAAAGC TACACACCCT701 TCATCCAAAC CGACGTTGCC ATCAATCCGG GCAACTCCGG CGGCCCGCTG 751TTCAACTTAA AAGGACAGGT CGTCGGCATC AACTCGCAAA TATACAGCCG 801 CAGCGGCGGATTCATGGGCA TTTCCTTCGC CATCCCGATT GACGTTGCCA 851 TGAATGTCGC CGAACAGCTGAAAAACACCG GCAAAGTCCA ACGCGGACAA 901 CTGGGCGTGA TTATTCAAGA AGTATCCTACGGTTTGGCAC AATCGTTCGG 951 TTTGGACAAA GCCGGCGGCG CACTGATTGC CAAAATCCTGCCCGGCAGCC 1001 CCGCAGAACG TGCCGGCCTG CGGGCGGGCG ACATCGTCCT CAGCCTCGAC1051 GGCGGAGAAA TACGTTCTTC CGGCGACCTT CCCGTTATGG TCGGCGCCAT 1101TACGCCGGGA AAAGAAGTCA GCCTCGGCGT ATGGCGCAAA GGCGAAGAAA 1151 TCACAATCAAAGTCAAGCTG GGCAACGCCG CCGAGCATAT CGGCGCATCA 1201 TCCAAAACAG ATGAAGCCCCCTACACCGAA CAGCAATCCG GTACGTTCTC 1251 GGTCGAATCC GCAGGCATTA CCCTTCAGACACATACCGAC AGCAGCGGCG 1301 GACACCTCGT CGTCGTACGG GTTTCCGACG CGGCAGAACGCGCAGGCTTG 1351 AGGCGCGGCG ACGAAATTCT TGCCGTCGGG CAAGTCCCCG TCAATGACGA1401 AGCCGGTTTC CGCAAAGCTA TGGACAAGGC AGGCAAAAAC GTCCCCCTGC 1451TGATCATGCG CCGTGGCAAC ACGCTGTTTA TCGCATTAAA CCTGCAATAAThis corresponds to the amino acid sequence <SEQ ID 2972; ORF 986.a>:

a986.pep 1 VFKKYQYLAL AALCAASLAG CDKAGSFFGA DKKEASFVER IKHTKDDGSV 51SMLLPDFVQL VQSEGPAVVN IQAAPAPRTQ NGSSNAETDS DPLADSDPFY 101 EFFKRLVPNMPEIPQEEADD GGLNFGSGFI ISKDGYILTN THVVTGMGSI 151 KVLLNDKREY TAKLIGSDVQSDVALLKIDA TEELPVVKIG NPKDLKPGEW 201 VAAIGAPFGF DNSVTAGXVS AKGRSLPNESYTPFIQTDVA INPGNSGGPL 251 FNLKGQVVGI NSQIYSRSGG FMGISFAIPI DVAMNVAEQLKNTGKVQRGQ 301 LGVIIQEVSY GLAQSFGLDK AGGALIAKIL PGSPAERAGL RAGDIVLSLD351 GGEIRSSGDL PVMVGAITPG KEVSLGVWRK GEEITIKVKL GNAAEHIGAS 401SKTDEAPYTE QQSGTFSVES AGITLQTHTD SSGGHLVVVR VSDAAERAGL 451 RRGDEILAVGQVPVNDEAGF RKAMDKAGKN VPLLIMRRGN TLFIALNLQ* m986/a986 98.2% identity in499 aa overlap        10        20        30        40        50        60 m986.pepVFKKYQYLALAALCAASLAGCDKAGSFFVADKKEASFVERIEHTKDDGSVSMLLPDFAQL|||||||||||||||||||||||||||| ||||||||||||:|||||||||||||||:|| a986VFKKYQYLALAALCAASLAGCDKAGSFFGADKKEASFVERIKHTKDDGSVSMLLPDFVQL        10        20        30        40        50        60        70        80        90       100       110       120 m986.pepVQSEGPAVVNIQAAPAPRTQNGSGNAENDSDPIADNDPFYEFFKRLVPNMPEIPQEEADD|||||||||||||||||||||||:|||:||||:||:|||||||||||||||||||||||| a986VQSEGPAVVNIQAAPAPRTQNGSSNAETDSDPLADSDPFYEFFKRLVPNMPEIPQEEADD        70        80        90       100       110       120       130       140       150       160       170       180 m986.pepGGLNFGSGFIISKDGYILTNTHVVTGMGSIKVLLNDKREYTAKLIGSDVQSDVALLKIDA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a986GGLNFGSGFIISKDGYILTNTHVVTGMGSIKVLLNDKREYTAKLIGSDVQSDVALLKIDA       130       140       150       160       170       180       190       200       210       220       230       240 m986.pepTEELPVVKIGNPKDLKPGEWVAAIGAPFGFDNSVTAGIVSAKGRSLPNESYTPFIQTDVA||||||||||||||||||||||||||||||||||||| |||||||||||||||||||||| a986TEELPVVKIGNPKDLKPGEWVAAIGAPFGFDNSVTAGXVSAKGRSLPNESYTPFIQTDVA       190       200       210       220       230       240       250       260       270       280       290       300 m986.pepINPGNSGGPLFNLKGQVVGINSQIYSRSGGFMGISFAIPIDVAMNVAEQLKNTGKVQRGQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a986INPGNSGGPLFNLKGQVVGINSQIYSRSGGFMGISFAIPIDVAMNVAEQLKNTGKVQRGQ       250       260       270       280       290       300       310       320       330       340       350       360 m986.pepLGVIIQEVSYGLAQSFGLDKAGGALIAKILPGSPAERAGLQAGDIVLSLDGGEIRSSGDL||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||| a986LGVIIQEVSYGLAQSFGLDKAGGALIAKILPGSPAERAGLRAGDIVLSLDGGEIRSSGDL       310       320       330       340       350       360       370       380       390       400       410       420 m986.pepPVMVGAITPGKEVSLGVWRKGEEITIKVKLGNAAEHIGASSKTDEAPYTEQQSGTFSVES|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a986PVMVGAITPGKEVSLGVWRKGEEITIKVKLGNAAEHIGASSKTDEAPYTEQQSGTFSVES       370       380       390       400       410       420       430       440       450       460       470       480 m986.pepAGITLQTHTDSSGGHLVVVRVSDAAERAGLRRGDEILAVGQVPVNDEAGFRKAMDKAGKN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a986AGITLQTHTDSSGGHLVVVRVSDAAERAGLRRGDEILAVGQVPVNDEAGFRKAMDKAGKN       430       440       450       460       470       480       490       500 m986.pep VPLLIMRRGNTLFIALNLQX ||||||||||||||||||||a986 VPLLIMRRGNTLFIALNLQX        490       500The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2973>:

g987.seq 1 ATGAAAACAC GCAGCCTCAT TTCCCTTTTA TGCCTCCTTC TCTGTTCATG 51TTCTTCATGG TTGCCCCCAC TGGAAGAACG GACGGAAAGC CGTCATTTTA 101 ATACTTCCAAACCTGTCCTC CTGGACAACA TCCTGCAAAT CCGGCACACC 151 CCTCATAACA ACGGGCTATCCGACATCTAC CTGCTCGACG ACCCCCACGA 201 AGCCTTTGCC GCCCGCGCCG CCCTTATCGAATCTGCCGAA CACAGCCTCG 251 ATTTGCAATA CTACATTTGG CGCAACGaCA TTTCCGGCAGGCTGCTGTTC 301 AACCTCATGT ACCTTGCCGC agaacgcGGC GTGCGCGTAC GCCTGCTGTt351 ggacgacaAC AACAcgcgcg gcttggacga tctcctGCTC GCCCTCGACA 401GCCATCCCAA TAtctaagtG CGCCTGTTCA ACCCCTtcgt CCTACGCAAA 451 TGGCGCGCACTCGGCTACCT GACCGACTTC CCCCGCCTCA ACCGCCGCAT 501 GCACAACAAA TCCTTTACCGCCGACAACCG CGCCACCATA CTCGGCGGAC 551 GCAATATCGG CGACGAATAC TTCAAAGTCGGTGAGGACAC CGTTTTCGCC 601 GACCTGGACA TCCTCGCCAC CGGCAGCGTC GTCGGCGAAGTATCGCACGA 651 CTTCGACCGC TACTGGGCAA GCCATTCCGC CCACAACGCC ACGCGCATCA701 TCCGCAGCGG CAACATCGGC AAGGGTCTTC AAGCACTCGG ATACAACGAC 751GAAACATCCA GACACGCGCT CCTGCGCTAC CGCGAAACCG TCGAACAGTC 801 GCCCCTCTACCAAAAAATAC AGACGGGACG CATCGACTGG CAGAGCGTCC 851 AAACCCGCCT GATCAGCGACAGCCCTGCAA AAGGACTCGA CCGCGACCGC 901 CGCAAACCGC CGATTGCCGG GAGGCTGCAAGACGCGCTCA AACAGCCCGA 951 AAAAAGCGTC TATCTGGTTT CACCCTATTT CGTCCCTACAAAATCCGGCA 1001 CAGACGCACT GGCAAAACTG GTGCAGGACG GCATAGACGT TACCGTCCTG1051 ACCAACTCGC TACAGGCGAC CGACGTTGCC GCCGTCCATT CCGGCTACGT 1101CAAATACCGA AAACCGCTGC TCAAAGCCGG CATCAAACTC TACGAGCTGC 1151 AACCCAACCATGCCGTCCCC GCCACAAAAG ACAAAGGCCT GACCGGCAGC 1201 TCCGTAACCA GCCTGCATGCCAAAACCTTC ATTGTGGacg gCAAACGCAT 1251 CTTCATCGGC TCATTCAACC TCGACCCCCGTTCCGCACGG CTCAATACCG 1301 AAATGGGCGT CGTCATCGAA AGCCCCAAAA TCGCAGAACAGATGGAGCGC 1351 AccctCGCCG AtacCACACC CGAATACGCC TACCGCGTTA CCCTCGACAA1401 ACACAACCGC CTGCAATGGC ACGATCCCGC CACCCGAAAA ACCTACCCGA 1451ACGAACCCGA AGCCAAACTT TGGAAACGCA TCGCCGCAAA AATCCTATCC 1501 CTGCTGCCCATCGAAGGTTT ATTATAGThis corresponds to the amino acid sequence <SEQ ID 2974; ORF 987.ng>:

g987.pep 1 MKTRSLISLL CLLLCSCSSW LPPLEERTES RHFNTSKPVL LDNILQIRHT 51PHNNGLSDIY LLDDPHEAFA ARAALIESAE HSLDLQYYIW RNDISGRLLF 101 NLMYLAAERGVRVRLLLDDN NTRGLDDLLL ALDSHPNI*V RLFNPFVLRK 151 WRALGYLTDF PRLNRRMHNKSFTADNRATI LGGRNIGDEY FKVGEDTVFA 201 DLDILATGSV VGEVSHDFDR YWASHSAHNATRIIRSGNIG KGLQALGYND 251 ETSRHALLRY RETVEQSPLY QKIQTGRIDW QSVQTRLISDSPAKGLDRDR 301 RKPPIAGRLQ DALKQPEKSV YLVSPYFVPT KSGTDALAKL VQDGIDVTVL351 TNSLQATDVA AVHSGYVKYR KPLLKAGIKL YELQPNHAVP ATKDKGLTGS 401SVTSLHAKTF IVDGKRIFIG SFNLDPRSAR LNTEMGVVIE SPKIAEQMER 451 TLADTTPEYAYRVTLDKHNR LQWHDPATRK TYPNEPEAKL WKRIAAKILS 501 LLPIEGLL*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2975>:

m987.seq 1 ATGAAAACAC GCAGCCTAAT TTCCCTTTTA TGCCTCCTTC TCTGTTCATG 51TTCTTCATGG TTGCCCCCAC TGGAAGAACG GACGGAAAGC CGTCATTTCA 101 ATACTTCCAAACCCGTCCGC CTGGACAACA TCCTGCAAAT CCGGCACACC 151 CCTCATACCA ACGGGCTATCCGATATCTAT CTGTTGAACG ACCCCCACGA 201 AGCCTTTGCC GCCCGCGCCG CCCTTATCGAATCTGCCGAA CACAGCCTCG 251 ATTTGCAATA CTACATCTGG CGCAACGACA TTTCCGGCAGGCTGCTGTTC 301 AACCTCGTGT ACCTTGCCGC AGAACGCGGT GTGCGCGTAC GCCTGCTGTT351 GGACGACAAC AACACGCGCG GATTGGACGA CCTCCTGCTT GCCCTCGACA 401GCCATCCCAA TATCGAAGTG CGCCTGTTCA ACCCCTTCGT CTTACGAAAA 451 TGGCGCGCACTCGGCTACCT GACCGACTTC CCCCGCCTCA ACCGCCGCAT 501 GCACAACAAA TCCTTTACCGCCGACAACCG CGCCACCATA CTCGGCGGAC 551 GCAATATCGG CGACGAATAC TTCAAAGTCGGTGAGGACAC CGTTTTCGCC 601 GATTTGGACA TCCTCGCCAC CGGCAGCGTC GTCGGCGAAGTATCGCACGA 651 CTTCGACCGC TACTGGGCAA GCCATTCCGC CCACAACGCC ACGCGCATCA701 TCCGCAGCGG CGACATCGGC AAGGGTCTTC AAGCACTCGG ATACAACGAC 751GAAACGTCCA GACACGCGCT CCTGCGCTAC CGCGAAACCG TCGAACAGTC 801 GCCCCTCTACCAAAAAATAC AGACAGGATG CATCGACTGG CAGAGCGTCC 851 GAACCCGCCT CATCAGCGACGACCCTGCAA AAGGACTCGA CCGCGACCGC 901 CGCAAACCGC CGATTGCCGG GCGGCTGCAAGACGCGCTCA AACAGCCCGA 951 AAAAAGCGTC TATCTGGTTT CACCCTATTT CGTTCCCACAAAATCCGGCA 1001 CAGACGCACT GGCAAAACTG GTGCAGGACG GCATAGACGT TACCGTTCTG1051 ACCAACTCGC TGCAGGCGAC CGACGTTGCC GCCGTCCATT CCGGCTATGT 1101CAAATACCGA AAACCGCTGC TCAAAGCCGG CATCAAACTC TACGAGCTGC 1151 AACCCAACCATGCCGTCCCC GCCACAAAAG ACAAAGGCCT GACCGGCAGC 1201 TCCGTAACCA GCCTGCACGCCAAAACCTTC ATTGTGGACG GCAAACGCAT 1251 CTTCATCGGT TCGTTCAACC TCGACCCCCGTTCCGCGCGT CTCAACACCG 1301 AAATGGGCGT TGTTATCGAA AGCCCCAAAA TCGCAGAACAGATGGAGCGC 1351 ACCCTTGCCG ATACCACACC CGCCTACGCC TACCGCGTTA CCCTCGACAG1401 GCACAACCGC CTGCAATGGC ACGATCCCGC CACCCGAAAA ACCTACCCGA 1451ACGAACCCGA AGCCAAACTT TGGAAACGCA TCGCCGCAAA AATCCTATCC 1501 CTGCTGCCCATAGAAGGTTT ATTATAGThis corresponds to the amino acid sequence <SEQ ID 2976; ORF 987>:

m987.pep 1 MKTRSLISLL CLLLCSCSSW LPPLEERTES RHFNTSKPVR LDNILQIRHT 51PHTNGLSDIY LLNDPHEAFA ARAALIESAE HSLDLQYYIW RNDISGRLLF 101 NLVYLAAERGVRVRLLLDDN NTRGLDDLLL ALDSHPNIEV RLFNPFVLRK 151 WRALGYLTDF PRLNRRMHNKSFTADNRATI LGGRNIGDEY FKVGEDTVFA 201 DLDILATGSV VGEVSHDFDR YWASHSAHNATRIIRSGDIG KGLQALGYND 251 ETSRHALLRY RETVEQSPLY QKIQTGCIDW QSVRTRLISDDPAKGLDRDR 301 RKPPIAGRLQ DALKQPEKSV YLVSPYFVPT KSGTDALAKL VQDGIDVTVL351 TNSLQATDVA AVHSGYVKYR KPLLKAGIKL YELQPNHAVP ATKDKGLTGS 401SVTSLHAKTF IVDGKRIFIG SFNLDPRSAR LNTEMGVVIE SPKIAEQMER 451 TLADTTPAYAYRVTLDRHNR LQWHDPATRK TYPNEPEAKL WKRIAAKILS 501 LLPIEGLL*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m987/g987 97.8% identity in 508 aa overlap        10        20        30        40        50        60 m987.pepMKTRSLISLLCLLLCSCSSWLPPLEERTESRHFNTSKPVRLDNILQIRHTPHTNGLSDIY||||||||||||||||||||||||||||||||||||||| ||||||||||||:||||||| g987MKTRSLISLLCLLLCSCSSWLPPLEERTESRHFNISKPVLLDNILQIRHIPHNNGLSDIY        10        20        30        40        50        60        70        80        90       100       110       120 m987.pepLLNDPHEAFAARAALIESAEHSLDLQYYIWRNDISGRLLFNLVYLAAERGVRVRLLLDDN||:|||||||||||||||||||||||||||||||||||||||:||||||||||||||||| g987LLDDPHEAFAARAALIESAEHSLDLQYYIWRNDISGRLLFNLMYLAAERGVRVRLLLDDN        70        80        90       100       110       120       130       140       150       160       170       180 m987.pepNTRGLDDLLLALDSHPNIEVRLFNPFVLRKWRALGYLTDFPRLNRRMHNKSFTADNRATI|||||||||||||||||| ||||||||||||||||||||||||||||||||||||||||| g987NTRGLDDLLLALDSHPNIXVRLFNPFVLRKWRALGYLTDFPRLNRRMHNKSFTADNRATI       130       140       150       160       170       180       190       200       210       220       230       240 m987.pepLGGRNIGDEYFKVGEDTVFADLDILATGSVVGEVSHDFDRYWASHSAHNATRIIRSGDIG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| g987LGGRNIGDEYFKVGEDTVFADLDILATGSVVGEVSHDFDRYWASHSAHNATRIIRSGNIG       190       200       210       220       230       240       250       260       270       280       290       300 m987.pepKGLQALGYNDETSRHALLRYRETVEQSPLYQKIQTGCIDWQSVRTRLISDDPAKGLDRDR|||||||||||||||||||||||||||||||||||| ||||||:||||||:||||||||| g987KGLQALGYNDETSRHALLRYRETVEQSPLYQKIQTGRIDWQSVQTRLISDSPAKGLDRDR       250       260       270       280       290       300       310       320       330       340       350       360 m987.pepRKPPIAGRLQDALKQPEKSVYLVSPYFVPTKSGTDALAKLVQDGIDVTVLTNSLQATDVA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g987RKPPIAGRLQDALKQPEKSVYLVSPYFVPTKSGTDALAKLVQDGIDVTVLTNSLQATDVA       310       320       330       340       350       360       370       380       390       400       410       420 m987.pepAVHSGYVKYRKPLLKAGIKLYELQPNHAVPATKDKGLTGSSVTSLHAKTFIVDGKRIFIG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g987AVHSGYVKYRKPLLKAGIKLYELQPNHAVPATKDKGLTGSSVTSLHAKTFIVDGKRIFIG       370       380       390       400       410       420       430       440       450       460       470       480 m987.pepSFNLDPRSARLNTEMGVVIESPKIAEQMERTLADTTPAYAYRVTLDRHNRLQWHDPATRK||||||||||||||||||||||||||||||||||||| ||||||||:||||||||||||| g987SFNLDPRSARLNTEMGVVIESPKIAEQMERTLADTTPEYAYRVTLDKHNRLQWHDPATRK       430       440       450       460       470       480       490       500      509 m987.pep TYPNEPEAKLWKRIAAKILSLLPIEGLLX||||||||||||||||||||||||||||| g987 TYPNEPEAKLWKRIAAKILSLLPIEGLLX       490       500The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2977>:

a987.seq 1 ATGAAAACAC GCAGCCTAAT TTCCCTTTTA TGCCTCCTTC TCTGTTCATG 51TTCTTCATGG TTGCCCCCAC TGGAAGAACG GACGGAAAGC CGTCATTTCA 101 ATACTTCCAAACCCGTCCGC CTGGACAACA TCCTGCAAAT CCGGCACACC 151 CCTCATACCA ACGGGCTATCCGATATCTAT CTGTTGAACG ACCCCCACGA 201 AGCCTTTGCC GCCCGCGCCG CCCTTATCGAATCTGCCGAA CACAGCCTCG 251 ATTTGCAATA CTACATCTGG CGCAACGACA TTTCCGGCCGACTGCTGTTC 301 AACCTCGTGT ACCTTGCCGC AGAACGCGGT GTGCGCGTAC GCCTGCTGTT351 GGACGACAAC AACACGCGCG GATTGGACGA CCTCCTGCTC GACCTGGACA 401GCCATCCCAA TATCGAAGTG CGCCTGTTCA ACCCCTTCGT CTTACGAAAA 451 TGGCGCGCACTCGGCTACCT GACCGACTTC CCCCGCCTCA ACCGCCGCAT 501 GCACAACAAA TCCTTTACCGCCGACAACCG CGCCACCATA CTCGGCGGAC 551 GCAATATCGG CGACGAATAC TTCAAAGTCGGTGAGGACAC CGTTTTCGCC 601 GACCTGGACA TCCTCGCCAC CGGCAGCGTC GTCGGCGAAGTATCGCACGA 651 CTTCGACCGC TACTGGGCAA GCCATTCCGC CCACAACGCC ACGCGCATCA701 TCCGCAGCGG CAACATCGGC AAGGGTCTTC AAGCACTCGG ATACAACGAC 751GAAACGTCCA GACACGCGCT CCTGCGCTAC CGCGAAACCG TCGAACAGTC 801 GCCCCTCTACCAAAAAATAC AGACAGGACG CATCGACTGG CAGAGCGTCC 851 AAACCCGCCT CATCAGCGACGACCCTGCAA AAGGACTCGA CCGCGACCGC 901 CGCAAACCGC CGATTGCCGG GCGGCTGCAAGACGCGCTCA AACAGCCCGA 951 AAAAAGCGTC TATCTGGTTT CACCCTATTT CGTCCCCACAAAATCCGGCA 1001 CAGACGCACT GGCAAAACTG GTGCAGGACG GCATAGACGT TACCGTCCTG1051 ACCAACTCGC TACAGGCGAC CGACGTTGCC GCCGTCCATT CCGGCTATGT 1101CAAATACCGA AAACCGCTGC TCAAAGCCGG CATCAAACTC TACGAGCTGC 1151 AACCCAACCATGCCGTCCCT GCCACAAAAG ACAAAGGCCT GACCGGCAGC 1201 TCCGTAACCA GCCTGCATGCCAAAACCTTC ATTGTGGACG GCAAACGCAT 1251 CTTCATCGGC TCATTCAACC TCGACCCCCGTTCCGCACGG CTCAATACTG 1301 AAATGGGCGT TGTTATCGAA AGCCCCAAAA TCGCAGAACAGATGGAGCGC 1351 ACCCTTGCCG ATACCTCACC CGAATACGCC TACCGCGTTA CCCTCGACAG1401 GCACAACCGC CTGCAATGGC ACGATCCCGC CACCCGAAAA ACCTACCCGA 1451ACGAACCCGA AGCCAAACTT TGGAAACGCA TCGCCGCAAA AATCCTATCC 1501 CTGCTGCCCATAGAAAGTTT ATTATAGThis corresponds to the amino acid sequence <SEQ ID 550; ORF 2978.a>:

a987.pep 1 MKTRSLISLL CLLLCSCSSW LPPLEERTES RHFNTSKPVR LDNILQIRHT 51PHTNGLSDIY LLNDPHEAFA ARAALIESAE HSLDLQYYIW RNDISGRLLF 101 NLVYLAAERGVRVRLLLDDN NTRGLDDLLL ALDSHPNIEV RLFNPFVLRK 151 WRALGYLTDF PRLNRRMHNKSFTADNRATI LGGRNIGDEY FKVGEDTVFA 201 DLDILATGSV VGEVSHDFDR YWASHSAHNATRIIRSGNIG KGLQALGYND 251 ETSRHALLRY RETVEQSPLY QKIQTGRIDW QSVQTRLISDDPAKGLDRDR 301 RKPPIAGRLQ DALKQPEKSV YLVSPYFVPT KSGTDALAKL VQDGIDVTVL351 TNSLQATDVA AVHSGYVKYR KPLLKAGIKL YELQPNHAVP ATKDKGLTGS 401SVTSLHAKTF IVDGKRIFIG SFNLDPRSAR LNTEMGVVIE SPKIAEQMER 451 TLADTSPEYAYRVTLDRHNR LQWHDPATRK TYPNEPEAKL WKRIAAKILS 501 LLPIESLL* m987/a98798.8% identity in 508 aa overlap        10        20        30        40        50        60 m987.pepMKTRSLISLLCLLLCSCSSWLPPLEERTESRHFNTSKPVRLDNILQIRHTPHTNGLSDIY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a987MKTRSLISLLCLLLCSCSSWLPPLEERTESRHFNTSKPVRLDNILQIRHTPHTNGLSDIY        10        20        30        40        50        60        70        80        90       100       110       120 m987.pepLLNDPHEAFAARAALIESAEHSLDLQYYIWRNDISGRLLFNLVYLAAERGVRVRLLLDDN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a987LLNDPHEAFAARAALIESAEHSLDLQYYIWRNDISGRLLFNLVYLAAERGVRVRLLLDDN        70        80        90       100       110       120       130       140       150       160       170       180 m987.pepNTRGLDDLLLALDSHPNIEVRLFNPFVLRKWRALGYLTDFPRLNRRMHNKSFTADNRATI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a987NTRGLDDLLLALDSHPNIEVRLFNPFVLRKWRALGYLTDFPRLNRRMHNKSFTADNRATI       130       140       150       160       170       180       190       200       210       220       230       240 m987.pepLGGRNIGDEYFKVGEDTVFADLDILATGSVVGEVSHDFDRYWASHSAHNATRIIRSGDIG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|| a987LGGRNIGDEYFKVGEDTVFADLDILATGSVVGEVSHDFDRYWASHSAHNATRIIRSGNIG       190       200       210       220       230       240       250       260       270       280       290       300 m987.pepKGLQALGYNDETSRHALLRYRETVEQSPLYQKIQTGCIDWQSVRTRLISDDPAKGLDRDR|||||||||||||||||||||||||||||||||||| ||||||:|||||||||||||||| a987KGLQALGYNDETSRHALLRYRETVEQSPLYQKIQTGRIDWQSVQTRLISDDPAKGLDRDR       250       260       270       280       290       300       310       320       330       340       350       360 m987.pepRKPPIAGRLQDALKQPEKSVYLVSPYFVPTKSGTDALAKLVQDGIDVTVLTNSLQATDVA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a987RKPPIAGRLQDALKQPEKSVYLVSPYFVPTKSGTDALAKLVQDGIDVTVLTNSLQATDVA       310       320       330       340       350       360       370       380       390       400       410       420 m987.pepAVHSGYVKYRKPLLKAGIKLYELQPNHAVPATKDKGLTGSSVTSLHAKTFIVDGKRIFIG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a987AVHSGYVKYRKPLLKAGIKLYELQPNHAVPATKDKGLTGSSVTSLHAKTFIVDGKRIFIG       370       380       390       400       410       420       430       440       450       460       470       480 m987.pepSFNLDPRSARLNTEMGVVIESPKIAEQMERTLADTTPAYAYRVTLDRHNRLQWHDPATRK|||||||||||||||||||||||||||||||||||:| |||||||||||||||||||||| a987SFNLDPRSARLNTEMGVVIESPKIAEQMERTLADTSPEYAYRVTLDRHNRLQWHDPATRK       430       440       450       460       470       480       490       500      509 m987.pep TYPNEPEAKLWKRIAAKILSLLPIEGLLX|||||||||||||||||||||||||:||| a987 TYPNEPEAKLWKRIAAKILSLLPIEGLLX       490       500The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2979>:

g988.seq 1 ATGAATAAAA ATATTAAATC TTTAAATTTA CGGGAAAAAG ACCCGTTTTT 51AAGTCGTGAA AAACAGCGTT ATGAACATCC TTTGCCCAGT CGGgaATGGA 101 TAATCGAATTGTTGGAGCGC AAAGGTGTGC CTTCAAAAAT CGAATCGCTT 151 GCACGCGAGC TGTCGATTACGGAAGacgag tATGTCTTTT TTGAACGCCG 201 TCTGAaggCG atgGCGCGGG AcggtCAGGTTTTAATCAAC CGCCgaggcg 251 CagtTTGCGc gGCggacaag ctgGATTTGG TCAAATGccgCgtcgaggcg 301 catAAgGAcg gtttcggctt cgcCGTGCCG CTCATGCCGA TGGACGAAGG351 GGATTTCGTT TTATACGAAC GCCAgatgcg tggTGtcatG CAcggcgaca 401ccgttACCGT CCGTCCTGCg ggtatggaCC GCAGGGGccg ccgcGAAggg 451 acgtttctGGATATTGTCGA ACGCGCGCAA AGCAAAGTTG TCGGCCGTTT 501 CTATATGGAT AGGGGCGTGGCGATTTTGGA GCCGGAAGAC AAGCGTCTGA 551 ACCAAAGCAT CGTGTTGGAA CCGGACGGCGTGGCGCGTTT CAAACCCGAA 601 TCCGGTCAGG TTATCGTCGG CAAAATTGAG GTTTATCCCGAGCAAAACCG 651 GCCTGCAGTG GCAAAAATCA TTGAAGTTTT GGGCGATTAT GCCGACAGCG701 GGATGGAAAt cgAAATTGCC GTGCGCAAGC ATCATTTGCC GCAccgaTTC 751AGTGAagcgt gtGcCAAATC CGcgaaAAAA ATtcccgacc ATGTACGCAA 801 AAGCGATTTGAAAGGCCGCG TCGATTTGTG CGACCTTCCT TTGGTAACGA 851 TAGACGGCGA AACGGCGCGCGATTTCGACG ACGCGGTGTT TGCCGAAAAA 901 GTCGGACGCA ATTACCGCCT GGTCGTGGCGATTGCGGATG TCAGCCATTA 951 TGTCCGCCCT GACGATGCGA TTGATGCAGA TGCTCAAGAACGCAGTACCA 1001 GCGTGTATTT CCCGCGCCGT ATGATTCCGA TGCTGCCGGA AAACCTGTCC1051 AACGGCATCT GCTCGCTCAA TCCCGATGTC GAGCGTTTGT GTATGGTGTG 1101CGATATGGTC GTTACCTATG CGGGCAATAT CAAAGAATAC CGCTTCTATC 1151 CCGCCGTGATGCGCTCTCAT GCCCGCCTGA CCTACAACCA AGTTTGGAAA 1201 TGGCTTTCAG ACGGCATCGGGAATCCGCAC AAAGCCCAAA TCGACACGCT 1251 TTACAAGCTG TTTAAAATTT TGCAGAAAAAACGTCTGGCG CGCGGGGCGG 1301 TGGAGTTTGA AAGCGTCGAA ACCCAGATGA TTTTCGACGACAACGGCAAA 1351 ATCGAAAAAA TTGTCCCCGT CGTCCGCAAC gatGCCCACA AGCTGATTGA1401 AGAATGTATG CTGGCGGCGA ATGTTTGCGC GGCGGATTTT CTGTTGAAAA 1451ACAAACATAC GGCTTTGTTC CGCAACCATT TGGGCCCCAC GCCCGAAAAA 1501 CTCGCCACCCTGCGCGAGCA GCTCGGTCTG TTGGGGCTTC AACTTGGCGG 1551 CGGCGACAAC CCGTCGCCGAAAGACTATGC CGCGCTTGCC GAACAATTCA 1601 AAGGCAGGCC GGATGCCGAA TTGCTGCAAGTCATGATGTT GCGCTCCATG 1651 CAGCAGGCGG TTTACGAACC GCATTGCGAA GGGCATTTCGGTTTGGCTTA 1701 TGAAGCATAC GCCCACTTTA CCTCGCCCAT CCGCCGCTAT CCCGACCTGA1751 CCGTCCACCG TGCCATCAAA GCCGTATTGA ACCGGAAAAC CTACACGCCA 1801AACAAAAGCT GGCAGGCTTT GGGCGTGCAT ACTTCGTTTT GCGAACGCCG 1851 TGCCGACGATGCTGGCCGCG ATGTGGAAAA CTGGCTGAAA ACTTATTATA 1901 TGCGCGATAA GGTCGGTGAAATATTTGAAG GcaaaatCtc ccggggtgtg 1951 gcaaaTtttg gaATATTTGT CACTTTGGACGATATccata tcgacggtct 2001 ggtacaTATC AGCGatttgg gcgaAGATTA TTTCaacttccgccccgAAA 2051 TCATGGCAAT CGAAGGCGAA CGCAGCGGCA TCCGTTTCAA TATGGGGGAC2101 AGGGTTGCCG TCCGGGTCGC GCGTGCCGAT TTGGATGATG GAAAAATCGA 2151CTTTGTCCTA ATTGCCGGAG AAAGCGGCAG GCGGCGGAAG GTCAAATTAT 2201 CCGCATCTGCCAAACCGGCA GGGGCGGCGG GGAAAGGGAA ATCGAAAACC 2251 ACCGCCGAGA AAAAAACAGCCCGATGCGGC AAAGTAAGGG GAAGGGGCGT 2301 GCCTGCCGTT GCCGAATCGG GGAAAAAGGCAAAGAAACCG GTTCCGATTA 2351 AGGTCAAAAA ACGGAAAGGC AAATCATAAThis corresponds to the amino acid sequence <SEQ ID 2980; ORF 988.ng>:

g988.pep 1 MNKNIKSLNL REKDPFLSRE KQRYEHPLPS REWIIELLER KGVPSKIESL 51ARELSITEDE YVFFERRLKA MARDGQVLIN RRGAVCAADK LDLVKCRVEA 101 HKDGFGFAVPLMPMDEGDFV LYERQMRGVM HGDTVTVRPA GMDRRGRREG 151 TFLDIVERAQ SKVVGRFYMDRGVAILEPED KRLNQSIVLE PDGVARFKPE 201 SGQVIVGKIE VYPEQNRPAV AKIIEVLGDYADSGMEIEIA VRKHHLPHRF 251 SEACAKSAKK IPDHVRKSDL KGRVDLCDLP LVTIDGETARDFDDAVFAEK 301 VGRNYRLVVA IADVSHYVRP DDAIDADAQE RSTSVYFPRR MIPMLPENLS351 NGICSLNPDV ERLCMVCDMV VTYAGNIKEY RFYPAVMRSH ARLTYNQVWK 401WLSDGIGNPH KAQIDTLYKL FKILQKKRLA RGAVEFESVE TQMIFDDNGK 451 IEKIVPVVRNDAHKLIEECM LAANVCAADF LLKNKHTALF RNHLGPTPEK 501 LATLREQLGL LGLQLGGGDNPSPKDYAALA EQFKGRPDAE LLQVMMLRSM 551 QQAVYEPHCE GHFGLAYEAY AHFTSPIRRYPDLTVHRAIK AVLNRKTYTP 601 NKSWQALGVH TSFCERRADD AGRDVENWLK TYYMRDKVGEIFEGKISRGV 651 ANFGIFVTLD DIHIDGLVHI SDLGEDYFNF RPEIMAIEGE RSGIRFNMGD701 RVAVRVARAD LDDGKIDFVL IAGESGRRRK VKLSASAKPA GAAGKGKSKT 751TAEKKTARCG KVRGRGVPAV AESGKKAKKP VPIKVKKRKG KS*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2981>:

m988.seq (partial) 1 ..ACAGTTCTGG ATATTGTCGA ACGCGCGCAA AGCAAAGTGGTCGGCCGTTT 51   CTATATGGAT AGGGGCGTGG CGATTTTGGA GCCGGAAGAC AAGCGTCTGA101   ACCAAAGCAT CGTATTGGAA CCGGACGGCG TGGCGCGTTT CAAACCTGAA 151  TCCGGTCAGG TCATCGTCGG CGAAATTGAG GTTTATCCTG AGCAAAACCG 201  GCCGGCAGTG GCAAAAATCA TCGAAGTTTT GGGCGATTAT GCCGACAGCG 251  GCATGGAGAT TGAAATTGCC GTGCGCAAGC ATCATTTGCC GCACCAATTC 301  AGTGAAGCGT GTGCCAAAGC TGCGAAAAAA ATTCCCGTCC ATGTACGCAA 351  AAGCGATTTG AAAGGCCGCG TCGATTTGCG CGACCTGCCT TTGGTAACGA 401  TAGACGGCGA AACGGCGCGC GATTTCGACG ACGCGGTGTT TGCCGAAAAA 451  GTCGGACGCA ATTACCGTCT GGTCGTGGCG ATTGCGGATG TCAGCCATTA 501  TGTCCGCCCT GACGATGTGA TTGATGCAGA TGCTCAAGAA CGCAGTACCA 551  GCGTATATTT CCCGCGCCGT GTGATTCCGA TGCTGCCGGA AAACCTGTCT 601  AACGGCATTT GCTCGCTCAA TCCCGATGTC GAGCGTTTGT GTATGGTGTG 651  CGATATGGTC GTTACCTATG CGGGCAATAT CAAAGAATAC CGCTTCTACC 701  CCGCCGTAAT GCGCTCTCAT GCCCGCCTGA CCTACAACCA AGTTTGGAAA 751  TGGATTTCAG ACGGCATCGA CCATCCGTAC AAAGCCCAAA TCGACACCCT 801  TTACAAACTC TTCAAAATCC TTCAGAAAAA GCGTTTCGAA CGCGGCGCGG 851  TGGAGTTTGA AAGCGTCGAA ACCCAGATGA TTTTCGATGA CAACGGCAAA 901  ATCGAAAAAA TCGTCCCCGT TGTCCGCAAC GATGCCCACA AGCTGATTGA 951  AGAATGTATG CTGGCGGCGA ATGTTTGCGC AGCGGATTTC CTGTTGAAAA 1001  ACAAGCATAC GGCTTTGTTC CGCAACCATT TGGGCCCCAC GCCCGAAAAA 1051  CTCGCCACCC TGCGCGAGCA GCTCGGTCTG TTGGGGCTTC AACTTGGCGG 1101  CGGCGACAAC CCGTCGCCGA AAGACTATGC CGCGCTTGTC GAACAATTCA 1151  AAGGCAGACC TGATGCCGAA TTGCTGCAAG TCATGATGTT GCGCTCCATG 1201  CAGCAGGCGG TTTACGAACC GCATTGCGAC GGACACTTTG GTCTTGCCTA 1251  CGAAGCATAC GCCCACTTCA CCTCGCCCAT CCGCCGCTAT CCCGACCTGA 1301  CCGTACACCG CGCCATCAAA GCCGTGTTGA ATCAGCAAAC CTACACGCCA 1351  AAAAAAAGCT GGCAGGCTTT GGGCGTGCAT ACCTCGTTCT GTGAGCGCCG 1401  TGCCGACGAC GCCAGCCGCG ACGTGGAAAA CTGGCTGAAA ACCTATTATA 1451  TGCGCGATAA GGTCGGCGAA GTATTCGAAG GTAAAATCTC CGGCATGACC 1501  AGTTTTGGTA TCTTTGTAAC ACTGGACGGC ATCCACATTG ACGGCTTGGT 1551  GCATATCAGC GATTTGGGCG AAGACTATTT CAACTTCCGC CCCGAAATCA 1601  TGGCAATCGA AGGCGAACGC AGCGGCATCC GTTTCAACAT GGGGGACAGG 1651  GTTGCCGTCC GGGTCGCCCG TGCCGATTTG GATGACGGAA AAATCGATTT 1701  TGTCCTGATT GCCGGGGGGA GCGGCAGGGG GCGGAAAGTT AAATCATCCG 1751  CGTCTGCCAA ACCGGCAGGG ACGGCGGGGA AAGGGAAGCC GAAAACCGCC 1801  GCCGAGAAAA AAACAGCCCG AGGCGGCAAA GTAAGGGGAA GGGGCGCGTC 1851  TGCCGCCGCA GAATCGAGGA AAAAGGCAAA GAAACCGGTT CCGATTAAGG 1901  TAAAAAAACG GAAAGGCAAA TCATAAThis corresponds to the amino acid sequence <SEQ ID 2982; ORF 988>:

m988.pep (partial) 1 ..TVLDIVERAQ SKVVGRFYMD RGVAILEPED KRLNQSIVLEPDGVARFKPE 51   SGQVIVGEIE VYPEQNRPAV AKIIEVLGDY ADSGMEIEIA VRKHHLPHQF101   SEACAKAAKK IPVHVRKSDL KGRVDLRDLP LVTIDGETAR DFDDAVFAEK 151  VGRNYRLVVA IADVSHYVRP DDVIDADAQE RSTSVYFPRR VIPMLPENLS 201  NGICSLNPDV ERLCMVCDMV VTYAGNIKEY RFYPAVMRSH ARLTYNQVWK 251  WISDGIDHPY KAQIDTLYKL FKILQKKRFE RGAVEFESVE TQMIFDDNGK 301  IEKIVPVVRN DAHKLIEECM LAANVCAADF LLKNKHTALF RNHLGPTPEK 351  LATLREQLGL LGLQLGGGDN PSPKDYAALV EQFKGRPDAE LLQVMMLRSM 401  QQAVYEPHCD GHFGLAYEAY AHFTSPIRRY PDLTVHRAIK AVLNQQTYTP 451  KKSWQALGVH TSFCERRADD ASRDVENWLK TYYMRDKVGE VFEGKISGMT 501  SFGIFVTLDG IHIDGLVHIS DLGEDYFNFR PEIMAIEGER SGIRFNMGDR 551  VAVRVARADL DDGKIDFVLI AGGSGRGRKV KSSASAKPAG TAGKGKPKTA 601  AEKKTARGGK VRGRGASAAA ESRKKAKKPV PIKVKKRKGK S*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

m988/g988 94.2% identity in 642 aa overlap                                        10        20        30 m988.pep                                TVLDIVERAQSKVVGRFYMDRGVAILEPED                                | |||||||||||||||||||||||||||| g988  LYERQMRGVMHGDTVTVRPAGMDRRGRREGTFLDIVERAQSKVVGRFYMDRGVAILEPED         130       140       150       160       170       180          40        50        60        70        80        90 m988.pep  KRLNQSIVLEPDGVARFKPESGQVIVGEIEVYPEQNRPAVAKIIEVLGDYADSGMEIEIA  |||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||| g988  KRLNQSIVLEPDGVARFKPESGQVIVGKIEVYPEQNRPAVAKIIEVLGDYADSGMEIEIA         190       200       210       220       230       240         100       110       120       130       140       150 m988.pep  VRKHHLPHQFSEACAKAAKKIPVHVRKSDLKGRVDLRDLPLVTIDGETARDFDDAVFAEK  ||||||||:|||||||:||||| ||||||||||||| ||||||||||||||||||||||| g988  VRKHHLPHRFSEACAKSAKKIPDHVRKSDLKGRVDLCDLPLVTIDGETARDFDDAVFAEK         250       260       270       280       290       300         160       170       180       190       200       210 m988.pep  VGRNYRLVVAIADVSHYVRPDDVIDADAQERSTSVYFPRRVIPMLPENLSNGICSLNPDV  ||||||||||||||||||||||:|||||||||||||||||:||||||||||||||||||| g988  VGRNYRLVVAIADVSHYVRPDDAIDADAQERSTSVYFPRRMIPMLPENLSNGICSLNPDV         310       320       330       340       350       360         220       230       240       250       260       270 m988.pep  ERLCMVCDMVVTYAGNIKEYRFYPAVMRSHARLTYNQVWKWISDGIDHPYKAQIDTLYKL  |||||||||||||||||||||||||||||||||||||||||:|||| :|:|||||||||| g988  ERLCMVCDMVVTYAGNIKEYRFYPAVMRSHARLTYNQVWKWLSDGIGNPHKAQIDTLYKL         370       380       390       400       410       420         280       290       300       310       320       330 m988.pep  FKILQKKRFERGAVEFESVETQMIFDDNGKIEKIVPVVRNDAHKLIEECMLAANVCAADF  ||||||||: |||||||||||||||||||||||||||||||||||||||||||||||||| g988  FKILQKKRLARGAVEFESVETQMIFDDNGKIEKIVPVVRNDAHKLIEECMLAANVCAADF         430       440       450       460       470       480         340       350       360       370       380       390 m988.pep  LLKNKHTALFRNHLGPTPEKLATLREQLGLLGLQLGGGDNPSPKDYAALVEQFKGRPDAE  |||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||| g988  LLKNKHTALFRNHLGPTPEKLATLREQLGLLGLQLGGGDNPSPKDYAALAEQFKGRPDAE         490       500       510       520       530       540         400       410       420       430       440       450 m988.pep  LLQVMMLRSMQQAVYEPHCDGHFGLAYEAYAHFTSPIRRYPDLTVHRAIKAVLNQQTYTP  |||||||||||||||||||:||||||||||||||||||||||||||||||||||::|||| g988  LLQVMMLRSMQQAVYEPHCEGHFGLAYEAYAHFTSPIRRYPDLTVHRAIKAVLNRKTYTP         550       560       570       580       590       600         460       470       480       490        500      509 m988.pep  KKSWQALGVHTSFCERRADDASRDVENWLKTYYMRDKVGEVFEGKIS-GMTSFGIFVTLD  :||||||||||||||||||||:||||||||||||||||||:|||||| |:::|||||||| g988  NKSWQALGVHTSFCERRADDAGRDVENWLKTYYMRDKVGEIFEGKISRGVANFGIFVTLD         610       620       630       640       650       660510       520       530       540       550       560      569 m988.pep  GIHIDGLVHISDLGEDYFNFRPEIMAIEGERSGIRFNMGDRVAVRVARADLDDGKIDFVL   ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g988  DIHIDGLVHISDLGEDYFNFRPEIMAIEGERSGIRFNMGDRVAVRVARADLDDGKIDFVL         670       680       690       700       710       720570       580       590       600       610       620      629 m988.pep  IAGGSGRGRKVKSSASAKPAGTAGKGKPKTAAEKKTARGGKVRGRGASAAAESRKKAKKP  ||| ||| |||| ||||||||:||||| ||:||||||| |||||||: |:||| |||||| g988  IAGESGRRRKVKLSASAKPAGAAGKGKSKTTAEKKTARCGKVRGRGVPAVAESGKKAKKP         730       740       750       760       770       780630       640 m988.pep   VPIKVKKRKGKSX   ||||||||||||| g988  VPIKVKKRKGKSX          790The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2983>:

a988.seq 1 ATGAATAAAA ATATTAAATC TTTAAATTTA CGGGAAAAAG ACCCGTTTTT 51AAGTCGTGAA AAACAGCGTT ATGAACATCC TTTGCCCAGT CGGGAATGGA 101 TAATCGAGCTGCTTGAACGT AAAGGCGTAC CATCCAAGAT TGAAGCTTTG 151 GTACGCGAAT TGTCGATTAAGGAAGAAGAG TACGAATTTT TCGAACGTCG 201 TCTGAAGGCG ATGGCGCGGG ACGGTCAGGTTTTAATCAAC CGTCGGGGCG 251 CGGTTTGCGC GGCGGACAAA TTGGATTTGG TCAAATGCCGTGTCAAGGCG 301 CACAAAGACC GCTTCGGTTT CGCCGTGCCG CTCACGCCCG CCAAAGACGG351 TGATTTTGTC TTGTACGAAC GCCAGATGCG CGGCATTATG CACGGCGATA 401TTGTCACTGT TCGTCCTGCC GGCATGGACG GTAGGGGCCG CCGCGAAGGG 451 ACGGTTCTGGATATTGTCGA ACGCGCGCAA AGCAAAGTGG TCGGCCGTTT 501 CTANATGGAT AGGGGCGTGGCGATTTTGGA GCCGGAAGAC AAGCGTCTGA 551 ACCAAAGCAT CGTATTGGAA CCGGACGGCGTGGCGCGTTT CAAACCTGAA 601 TCCGGTCAGG TCATCGTCGG CGAAATTGAG GTTTATCCTGAGCAAAACCG 651 GCCGGCAGTG GCAAAAATCA TCGAAGTTTT GGGCGATTAT GCCGACAGCG701 GCATGGAGAT TGAAATTGCC GTGCGCAAGC ATCATTTGCC GCACCAATTC 751AGTGAAGCGT GTGCCAAAGC CGCGAAAAAA ATTCCCGACC ATGTACGCAA 801 AAGCGATTTGAAAGGCCGCG TCGATTTGCG CGACCTGCCT TTGGTAACGA 851 TAGACGGCGA AACGGCTCGAGATTTTGACG ATGCGGTGTT TGCCGAGAAA 901 ATCGGACGCA ATTACCGTCT GGTCGTGGCGATTGCCGATG TCAGCCATTA 951 TGTCCGCCCC GATGACGCTA TCGACACGGA CGCTCAGGAACGCAGCACCA 1001 GTGTTTACTT CCCGCGCCGC GTGATTCCCA TGTTGCCGGA AAACCTGTCC1051 AACGGCATCT GCTCGCTCAA TCCTCATGTC GAGCGTTTGT GTGTGGTGTG 1101CGATATGGTT ATCACTTACG CGGGCAATAT CAAAGAATAC CGCTTCTACC 1151 CCGCCGTGATGCGCTCTCAT GCCCGCCTGA CCTACAACCA AGTTTGGAAA 1201 TGGCTTTCAG GCGGCATCGAGCATCCGTTC AAAACCCAAA TCGACACGCT 1251 TTACAAACTC TTCAAAATCC TTCAGAAAAAGCGTTTCGAA CGCGGGGCGG 1301 TGGAGTTTGA CAGCATCGAA ACCCAAATGC TTTTCGACGACAACGGTAAA 1351 ATTGAAAAAA TCGTCCCCGT TGTCCGCAAC GATGCCCACA AGCTGATTGA1401 AGAATGTATG TTGGCGGCAA ACGTTTGCGC AGCGGATTTT CTGTTGAAAA 1451ACAAGCATAC CGCATTGTTC CGCAACCATT TGGGGCCCAC GCCCGAAAAA 1501 CTCGCCGCCTTGCGCGAGCA GCTCGGTCTG TTGGGGCTTC AACTTGGCGG 1551 CGGCGACAAC CCGTCGCCGAAAGACTATGC CGCGCTTGCC GGACAGTTCA 1601 AAGGCAGGCC GGATGCCGAA TTGCTGCAAGTCATGATGTT GCGCTCCATG 1651 CAACAGGCGG TTTACGAACC GCATTGCGAC GGACACTTTGGTCTTGCCTA 1701 CGAAGCATAC GCCCACTTCA CCTCGCCCAT CCGCCGCTAT CCCGACCTGA1751 CCGTACACCG CGCCATCAAA GCCGTGTTGA ATCAGCAAAC CTACACGCCA 1801AAAAAAAGCT GGCAGGCTTT GGGCGTGCAT ACCTCGTTCT GTGAGCGCCG 1851 TGCCGACGACGCCAGCCGCG ACGTGGAAAA CTGGCTGAAA ACCTATTATA 1901 TGCGCGATAA GGTCGGCGAAGTATTCGAAG GTAAAATCTC CGGCATGACC 1951 AGTTTTGGTA TCTTTGTAAC ACTGGACGGCATCCACATTG ACGGCTTGGT 2001 GCATATCAGC GATTTGGGCG AAGACTATTT CAACTTCCGCCCCGAAATCA 2051 TGGCAATCGA AGGCGAACGC AGCGGCATCC GTTTCAACAT GGGGGACAGG2101 GTTGCCGTCC GGGTCGCCCG TGCCGATTTG GATGACGGAA AAATCGATTT 2151TGTCCTGATT GCCGGGGGGA GCGGCAGGGG GCGGAAAGTT AAATCATCCG 2201 CGTCTGCCAAACCGGCAGGG ACGGCGGGGA AAGGGAAGCC GAAAACCGCC 2251 GCCGAGAAAA AAACAGCCCGAGGCGGCAAA GTAAGGGGAA GGGGCGCGTC 2301 TGCCGCCGCA GAATCGAGGA AAAAGGCAAAGAAACCGGTT CCGATTAAGG 2351 TAAAAAAACG GAAAGGCAAA TCATAAThis corresponds to the amino acid sequence <SEQ ID 2984; ORF 988.a>:

a988.pep 1 MNKNIKSLNL REKDPFLSRE KQRYEHPLPS REWIIELLER KGVPSKIEAL 51VRELSIKEEE YEFFERRLKA MARDGQVLIN RRGAVCAADK LDLVKCRVKA 101 HKDRFGFAVPLTPAKDGDFV LYERQMRGIM HGDIVTVRPA GMDGRGRREG 151 TVLDIVERAQ SKVVGRFXMDRGVAILEPED KRLNQSIVLE PDGVARFKPE 201 SGQVIVGEIE VYPEQNRPAV AKIIEVLGDYADSGMEIEIA VRKHHLPHQF 251 SEACAKAAKK IPDHVRKSDL KGRVDLRDLP LVTIDGETARDFDDAVFAEK 301 IGRNYRLVVA IADVSHYVRP DDAIDTDAQE RSTSVYFPRR VIPMLPENLS351 NGICSLNPHV ERLCVVCDMV ITYAGNIKEY RFYPAVMRSH ARLTYNQVWK 401WLSGGIEHPF KTQIDTLYKL FKILQKKRFE RGAVEFDSIE TQMLFDDNGK 451 IEKIVPVVRNDAHKLIEECM LAANVCAADF LLKNKHTALF RNHLGPTPEK 501 LAALREQLGL LGLQLGGGDNPSPKDYAALA GQFKGRPDAE LLQVMMLRSM 551 QQAVYEPHCD GHFGLAYEAY AHFTSPIRRYPDLTVHRAIK AVLNQQTYTP 601 KKSWQALGVH TSFCERRADD ASRDVENWLK TYYMRDKVGEVFEGKISGMT 651 SFGIFVTLDG IHIDGLVHIS DLGEDYFNFR PEIMAIEGER SGIRFNMGDR701 VAVRVARADL DDGKIDFVLI AGGSGRGRKV KSSASAKPAG TAGKGKPKTA 751AEKKTARGGK VRGRGASAAA ESRKKAKKPV PIKVKKRKGK S* m988/a988 97.0% identityin 641 aa overlap                                      10        20        30 m988.pep                              TVLDIVERAQSKVVGRFYMDRGVAILEPED                              ||||||||||||||||| |||||||||||| a988LYERQMRGIMHGDIVTVRPAGMDGRGRREGTVLDIVERAQSKVVGRFXMDRGVAILEPED       130       140       150       160       170       180        40        50        60        70        80        90 m988.pepKRLNQSIVLEPDGVARFKPESGQVIVGEIEVYPEQNRPAVAKIIEVLGDYADSGMEIEIA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a988KRLNQSIVLEPDGVARFKPESGQVIVGEIEVYPEQNRPAVAKIIEVLGDYADSGMEIEIA       190       200       210       220       230       240       100       110       120       130       140       150 m988.pepVRKHHLPHQFSEACAKAAKKIPVHVRKSDLKGRVDLRDLPLVTIDGETARDFDDAVFAEK|||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||| a988VRKHHLPHQFSEACAKAAKKIPDHVRKSDLKGRVDLRDLPLVTIDGETARDFDDAVFAEK       250       260       270       280       290       300       160       170       180       190       200       210 m988.pepVGRNYRLVVAIADVSHYVRPDDVIDADAQERSTSVYFPRRVIPMLPENLSNGICSLNPDV:|||||||||||||||||||||:||:|||||||||||||||||||||||||||||||| | a988IGRNYRLVVAIADVSHYVRPDDAIDTDAQERSTSVYFPRRVIPMLPENLSNGICSLNPHV       310       320       330       340       350       360       220       230       240       250       260       270 m988.pepERLCMVCDMVVTYAGNIKEYRFYPAVMRSHARLTYNQVWKWISDGIDHPYKAQIDTLYKL||||:|||||:||||||||||||||||||||||||||||||:| ||:||:|:|||||||| a988ERLCVVCDMVITYAGNIKEYRFYPAVMRSHARLTYNQVWKWLSGGIEHPFKIQIDTLYKL       370       380       390       400       410       420       280       290       300       310       320       330 m988.pepFKILQKKRFERGAVEFESVETQMIFDDNGKIEKIVPVVRNDAHKLIEECMLAANVCAADF||||||||||||||||:|:||||:|||||||||||||||||||||||||||||||||||| a988FKILQKKRFERGAVEFDSIETQMLFDDNGKIEKIVPVVRNDAHKLIEECMLAANVCAADF       430       440       450       460       470       480       340       350       360       370       380       390 m988.pepLLKNKHTALFRNHLGPTPEKLATLREQLGLLGLQLGGGDNPSPKDYAALVEQFKGRPDAE||||||||||||||||||||||:||||||||||||||||||||||||||: ||||||||| a988LLKNKHTALFRNHLGPTPEKLAALREQLGLLGLQLGGGDNPSPKDYAALAGQFKGRPDAE       490       500       510       520       530       540       400       410       420       430       440       450 m988.pepLLQVMMLRSMQQAVYEPHCDGHFGLAYEAYAHFTSPIRRYPDLTVHRAIKAVLNQQTYTP|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a988LLQVMMLRSMQQAVYEPHCDGHFGLAYEAYAHFTSPIRRYPDLTVHRAIKAVLNQQTYTP       550       560       570       580       590       600       460       470       480       490       500       510 m988.pepKKSWQALGVHTSFCERRADDASRDVENWLKTYYMRDKVGEVFEGKISGMTSFGIFVTLDG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a988KKSWQALGVHTSFCERRADDASRDVENWLKTYYMRDKVGEVFEGKISGMTSFGIFVTLDG       610       620       630       640       650       660       520       530       540       550       560       570 m988.pepIHIDGLVHISDLGEDYFNFRPEIMAIEGERSGIRFNMGDRVAVRVARADLDDGKIDFVLI|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a988IHIDGLVHISDLGEDYFNFRPEIMAIEGERSGIRFNMGDRVAVRVARADLDDGKIDFVLI       670       680       690       700       710       720       580       590       600       610       620       630 m988.pepAGGSGRGRKVKSSASAKPAGTAGKGKPKTAAEKKTARGGKVRGRGASAAAESRKKAKKPV|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a988AGGSGRGRKVKSSASAKPAGTAGKGKPKTAAEKKTARGGKVRGRGASAAAESRKKAKKPV       730       740       750       760       770       780        640m988.pep PIKVKKRKGKSX |||||||||||| a988 PIKVKKRKGKSX        790The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2985>:

g989.seq 1 ATGACCCCTT TCACACTGAA AAAAACCGTC CTGCTGCTCG GCACTGCCTT 51TGCCGCCGCA TCTGTCCACG CATCCGGCTA CCACTTCGGC ACACAGTCGG 101 TCAACGCGCAAAGCACGGCA AATGCCGCCG ACGCGTCGAC CATCTTCTAC 151 AATCCCGCCG GCCTGACCAAACTCGACAGC AGCCAGATTT CCGTCAACGC 201 CAACATCGTG CTGCCCAGCA TTCATTATGAAGCAGATTCC GCCACCGACT 251 TTACCGGGCT TCCCGTCCAA GGTTCTAAAA ACGGCAAAATCACCAAAACC 301 ACGGTCGCAC CCCACATTTA CGGCGCATAC AAAGTCAACG ACAATCTGAC351 CGTGGGCTTG GGCGTGTACG TCCCCTTCGG CTCTGCCACC GAATACGAAA 401AAGATTCCGT GTTGCGCCAC AACATCAACA AACTCGGTCT GACCAGCATC 451 GCCGTCGAACCTGTCGCCGC GTGGAAACTC AACGAACGCC ATTCCTTCGG 501 CGCAGGCATC ATCGCCCAACATAATTCCGC CGAACTGCGC AAATATGCCG 551 ACTGAGGAAT CCCAAAAAAA GCGCAAATGCTGCAAGCAAC ACCTTCTAAT 601 CCTACTGCCG CTGCTCAAAT CAAGGCCGAC GGACACGCCGATGTCAAAGG 651 CAGCGATTGG GGCGTCGGCT ACCAACTGGC GTGGATGTGG GACATCAACG701 ACCGCGCGCG CGTGGGCGTG AACTACCGTT CCAAAGTTTC ACACACGCTC 751AAAGGCGATG CCGAATGGGC GGCAGACGGC GCGGCGGCGA AACAACAGTG 801 GAATGACAATATGCTCACAC CGCTCGGTTA CACGGCGAAT GAAAAAGCCA 851 GTGTCAAAAT CGTAACGCCTGAGTCTTTGT CCGTACACGG CATGTACAAA 901 GTGTCCGACA AAGCCGACCT GTTCGGCGACGTAACTTGGA CGCGCCACAG 951 CCGCTTCAAT AAGGCGGAAC TGTTTTTTGA AAAAGAAAAAAATATTGCTA 1001 ATGGCAAAAA ATCCGACCGC ACCACCATCA CCCCCAACTG GCGCAACACC1051 TACAAAGTCG GCTTGGGCGG TTCTTATCAA ATCAGCGAAC CGCTGCAACT 1101GCGCGTCGGC ATCGCTTTTG ACAAACCGCC TGTCCGCAAC GCCGACTacC 1151 GCATGAACAGCCTGCCCGAC GGCAACCGCA TCTGGTTCTC CGCCGGCATG 1201 AAATACCATA TCGGCAAAAACCACGTCGTC GATGCCGCCT ACACCCACAT 1251 CCACATCAAC GACACCAGCT ACCGCACGGCGAAGGCAAGC GGCAACGATG 1301 TGGACAGCAA AGGTGCGTCT TGCGCACGTT TCAAAAACCACGCCGACATC 1351 ATCGGCCTGC AATACACCTA CAAATTCAAA TAAThis corresponds to the amino acid sequence <SEQ ID 2986; ORF 989.ng>:

g989.pep 1 MTPFTLKKTV LLLGTAFAAA SVHASGYHFG TQSVNAQSTA NAADASTIFY 51NPAGLTKLDS SQISVNANIV LPSIHYEADS ATDFTGLPVQ GSKNGKITKT 101 TVAPHIYGAYKVNDNLTVGL GVYVPFGSAT EYEKDSVLRH NINKLGLTSI 151 AVEPVAAWKL NERHSFGAGIIAQHNSAELR KYAD*GIPKK AQMLQATPSN 201 PTAAAQIKAD GHADVKGSDW GVGYQLAWMWDINDRARVGV NYRSKVSHTL 251 KGDAEWAADG AAAKQQWNDN MLTPLGYTAN EKASVKIVTPESLSVHGMYK 301 VSDKADLFGD VTWTRHSRFN KAELFFEKEK NIANGKKSDR TTITPNWRNT351 YKVGLGGSYQ ISEPLQLRVG IAFDKPPVRN ADYRMNSLPD GNRIWFSAGM 401KYHIGKNHVV DAAYTHIHIN DTSYRTAKAS GNDVDSKGAS CARFKNHADI 451 IGLQYTYKFK *The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2987>:

m989.seq 1 ATGACCCCTT CCGCACTGAA AAAAACCGTC CTGCTGCTCG GCACTGCCTT 51TGCCGCCGCA TCCGTCCACG CATCCGGCTA CCACTTCGGC ACACAGTCGG 101 TCAACGCGCAAAGCACGGCA AATGCCGCCG CCGCAGAAGC CGCCGACGCA 151 TCGACCATCT TCTACAACCCTGCCGGCCTG ACCAAACTCG ACAGCAGCCA 201 GATTTCCGTC AACGCCAACA TCGTGCTGCCCAGCATTCAT TATGAGGCGG 251 ATTCCGCCAC CGACTTTACC GGGCTTCCCG TCCAAGGTTCGAAAAGCGGC 301 AAAATCACCA AAACCACGGT CGCGCCCCAC ATCTACGGCG CATACAAAGT351 CAACGACAAT CTGACCGTGG GCTTGGGCGT GTACGTCCCC TTCGGCTCTG 401CCACCGAATA CGAAAAAGAT TCCGTGTTGC GCCACAACAT CAACAAACTC 451 GGTCTGACCAGCATCGCCGT CGAACCTGTC GCCGCGTGGA AACTCAACGA 501 CCGCCATTCC TTCGGCGCAGGCATCATCGC CCAACATACT TCCGCCGAAC 551 TGCGCAAATA TGCCGACTGG GGGATTAAGAGTAAAGCAGA GATATTGACG 601 GCAAAACCGC CCAAACCTAA CGGTGTAGCC GAAGCTGCAAAAATTCAGGC 651 CGACGGACAC GCCGATGTCA AAGGCAGCGA TTGGGGCTTC GGCTACCAAC701 TGGCGTGGAT GTGGGACATC AACGACCGTG CGCGCGTGGG CGTGAACTAC 751CGTTCCAAAG TCTCGCACAC GCTCAAAGGC GATGCCGAAT GGGCGGCAGA 801 CGGCGCGGCGGCGAAAGCAA TGTGGAGTAC GATGCTTGCA GCAAACGGCT 851 ACACGGCGAA TGAAAAAGCCCGCGTTAAAA TCGTTACGCC TGAGTCTTTG 901 TCCGTACACG GTATGTACAA AGTGTCCGATAAAGCCGACC TGTTCGGCGA 951 CGTAACTTGG ACGCGCCACA GCCGCTTCGA TAAGGCGGAACTGGTTTTTG 1001 AAAAAGAAAA AACCGTCGTC AAAGGCAAAT CCGACCGCAC CACCATCACC1051 CCCAACTGGC GCAACACCTA CAAAGTCGGC TTCGGCGGTT CTTATCAAAT 1101CAGCGAACCG CTGCAACTGC GCGCCGGCAT CGCTTTTGAC AAATCGCCCG 1151 TCCGCAACGCCGACTACCGC ATGAACAGCC TACCCGACGG CAACCGCATC 1201 TGGTTCTCCG CCGGTATGAAATACCATATC GGTAAAAACC ACGTCGTCGA 1251 TGCCGCCTAC ACCCACATCC ACATCAACGACACCAGCTAC CGCACGGCGA 1301 AGGCAAGCGG CAACGATGTG GACAGCAAAG GCGCGTCTTCCGCACGTTTC 1351 AAAAACCACG CCGACATCAT CGGTCTGCAA TACACCTACA AATTCAAATA1401 AThis corresponds to the amino acid sequence <SEQ ID 2988; ORF 989>:

m989.pep 1 MTPSALKKTV LLLGTAFAAA SVHASGYHFG TQSVNAQSTA NAAAAEAADA 51STIFYNPAGL TKLDSSQISV NANIVLPSIH YEADSATDFT GLPVQGSKSG 101 KITKTTVAPHIYGAYKVNDN LTVGLGVYVP FGSATEYEKD SVLRHNINKL 151 GLTSIAVEPV AAWKLNDRHSFGAGIIAQHT SAELRKYADW GIKSKAEILT 201 AKPPKPNGVA EAAKIQADGH ADVKGSDWGFGYQLAWMWDI NDRARVGVNY 251 RSKVSHTLKG DAEWAADGAA AKAMWSTMLA ANGYTANEKARVKIVTPESL 301 SVHGMYKVSD KADLFGDVTW TRHSRFDKAE LVFEKEKTVV KGKSDRTTIT351 PNWRNTYKVG FGGSYQISEP LQLRAGIAFD KSPVRNADYR MNSLPDGNRI 401WFSAGMKYHI GKNHVVDAAY THIHINDTSY RTAKASGNDV DSKGASSARF 451 KNHADIIGLQYTYKFK*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeae

g989/m989 90.0% identity in 468 aa overlap          10        20        30        40             50 g989.pep  MTPFTLKKTVLLLGTAFAAASVHASGYHFGTQSVNAQSTANAA-----DASTIFYNPAGL  ||| :||||||||||||||||||||||||||||||||||||||     |||||||||||| m989  MTPSALKKTVLLLGTAFAAASVHASGYHFGTQSVNAQSTANAAAAEAADASTIFYNPAGL          10        20        30        40        50        60     60        70        80        90       100       110 g989.pep  TKLDSSQISVNANIVLPSIHYEADSATDFTGLPVQGSKNGKITKTTVAPHIYGAYKVNDN  ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||| m989  TKLDSSQISVNANIVLPSIHYEADSATDFTGLPVQGSKSGKITKTTVAPHIYGAYKVNDN          70        80        90       100       110       120    120       130       140       150       160       170 g989.pep  LTVGLGVYVPFGSATEYEKDSVLRHNINKLGLTSIAVEPVAAWKLNERHSFGAGIIAQHN  ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||: m989  LTVGLGVYVPFGSATEYEKDSVLRHNINKLGLISIAVEPVAAWKLNDRHSFGAGIIAQHT         130       140       150       160       170       180    180       190       200       210       220       230 g989.pep  SAELRKYADXGIPKKAQMLQATPSNPTA---AAQIKADGHADVKGSDWGVGYQLAWMWDI  ||||||||| || :||::| | | :|::   ||:|:||||||||||||| |||||||||| m989  SAELRKYADWGIKSKAEILTAKPPKPNGVAEAAKIQADGHADVKGSDWGFGYQLAWMWDI         190       200       210       220       230       240       240       250       260       270       280       290 g989.pep  NDRARVGVNYRSKVSHTLKGDAEWAADGAAAKQQWNDNMLTPLGYTANEKASVKIVTPES  |||||||||||||||||||||||||||||||| :|: :||:  |||||||| |||||||| m989  NDRARVGVNYRSKVSHTLKGDAEWAADGAAAKAMWS-TMLAANGYTANEKARVKIVTPES         250       260       270        280       290       300       310       320       330       340       350 g989.pep  LSVHGMYKVSDKADLFGDVTWTRHSRFNKAELFFEKEKNIANGKKSDRTTITPNWRNTYK  |||||||||||||||||||||||||||:|||| |||||::::|| ||||||||||||||| m989  LSVHGMYKVSDKADLFGDVTWTRHSRFDKAELVFEKEKTVVKGK-SDRTTITPNWRNTYK300     310       320       330       340       350       360       370       380       390       400       410 g989.pep  VGLGGSYQISEPLQLRVGIAFDKPPVRNADYRMNSLPDGNRIWFSAGMKYHIGKNHVVDA  ||:|||||||||||||:|||||| |||||||||||||||||||||||||||||||||||| m989  VGFGGSYQISEPLQLRAGIAFDKSPVRNADYRMNSLPDGNRIWFSAGMKYHIGKNHVVDA 360      370       380       390       400       410       420       430       440       450       460 g989.pep  AYTHIHINDTSYRTAKASGNDVDSKGASCARFKNHADIIGLQYTYKFKX  |||||||||||||||||||||||||||| |||||||||||||||||||| m989  AYTHIHINDTSYRTAKASGNDVDSKGASSARFKNHADIIGLQYTYKFKX 420      430       440       450       460The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2989>:

a989.seq 1 ATGACCCCTT CCGCACTGAA AAAAACCGTC CTACTGCTCG GCACTGCCTT 51TGCCGCCGCA TCCGCACAAG CCTCCGGCTA CCACTTCGGC ACACAGTCGG 101 TCAACGCGCAAAGCACGGCA AATGCCGCCG CCGCAGAAGC CGCCGACGCA 151 TCGACCATCT TCTACAACCCTGCCGGCCTG ACCAAACTCG ACAGCAGCCA 201 GATTTCCGTC AACGCCAACA TCGTGCTGCCCAGCATTCAT TATGAGGCGG 251 ATTCCGCCAC CGACTTTACC GGGCTTCCCG TCCAAGGTTCGAAAAGCGGC 301 AAAATCACCA AAACCACGGT CGCGCCCCAC ATCTACGGCG CATACAAAGT351 CAACGACAAT CTGACCGTAG GCTTGGGCGT GTACGTCCCC TTCGGTTCTG 401CCACCGAATA CGAAAAAGAT TCCGTGTTGC GCCACAACAT CAACAAACTC 451 GGTCTGACCAGCATCGCCGT CGAACCTGTC GCCGCGTGGA AACTCAACGA 501 ACGCCATTCC TTCGGCGCAGGCATCATCGC CCAACATACT TCCGCCGAGC 551 TGCGCAAATA TGCCGACTGG GGGATTATGGAAAAAGCGAA AGCACTAAAA 601 GAAACACCCC CCAATCCAAC TAAAGCCGCC CAAATCAAAGCCGACGGACA 651 CGCCGATGTC AAAGGCAGCG ATTGGGGCTT CGGCTACCAA CTGGCGTGGA701 TGTGGGACAT CAACGACCGT GCGCGCGTGG GCGTGAACTA CCGTTCCAAA 751GTCTCACACA CGCTCAAAGG CGATGCCGAA TGGGCGGCAG ACGACGCAAT 801 GGCGAAACAGTTATGGGATG CAAACAAACT CGCACTGCTC GGCTACACGC 851 CAAGCGAAAA AGCCCGCGTTAAAATCGTTA CGCCCGAGTC TTTGTCCGTA 901 CACGGTATGT ACAAAGTGTC CGACAAAGCCGACCTGTTCG GCGACGTAAC 951 TTGGACGCGC CACAGCCGCT TCGATAAGGC GGAACTGGTTTTTGAAAAAG 1001 AAAAAACCAT CGTCAACGGC AAATCCGACC GCACCACCAT CACCCCCAAC1051 TGGCGCAACA CCTACAAAGT CGGCTTCGGC GGTTCTTATC AAATCAGCGA 1101ACCGCTGCAA CTGCGCGCCG GCATCGCTTT TGACAAATCG CCCGTCCGCA 1151 ACGCCGACTACCGCATGAAC AGCCTGCCCG ACGGCAACCG CATCTGGTTC 1201 TCCGCCGGCA TGAAATACCATATCGGCAAA AACCACGTCG TCGATGCCGC 1251 CTACACCCAC ATCCACATCA ACGACACCAGCTACCGCACG GCGAAGGCAA 1301 GCGGCAACGA TGTGGACAGC AAAGGCGCGT CTTCCGCACGTTTCAAAAAC 1351 CACGCCGACA TCATCGGCCT GCAATACACC TACAAATTCA AATAAThis corresponds to the amino acid sequence <SEQ ID 2990; ORF 989.a>:

a989.pep 1 MTPSALKKTV LLLGTAFAAA SAQASGYHFG TQSVNAQSTA NAAAAEAADA 51STIFYNPAGL TKLDSSQISV NANIVLPSIH YEADSATDFT GLPVQGSKSG 101 KITKTTVAPHIYGAYKVNDN LTVGLGVYVP FGSATEYEKD SVLRHNINKL 151 GLTSIAVEPV AAWKLNERHSFGAGIIAQHT SAELRKYADW GIMEKAKALK 201 ETPPNPTKAA QIKADGHADV KGSDWGFGYQLAWMWDINDR ARVGVNYRSK 251 VSHTLKGDAE WAADDAMAKQ LWDANKLALL GYTPSEKARVKIVTPESLSV 301 HGMYKVSDKA DLFGDVTWTR HSRFDKAELV FEKEKTIVNG KSDRTTITPN351 WRNTYKVGFG GSYQISEPLQ LRAGIAFDKS PVRNADYRMN SLPDGNRIWF 401SAGMKYHIGK NHVVDAAYTH IHINDTSYRT AKASGNDVDS KGASSARFKN 451 HADIIGLQYTYKFK* m989/a989 93.1% identity in 467 aa overlap          10        20        30        40        50        60 m989.pep  MTPSALKKTVLLLGTAFAAASVHASGYHFGTQSVNAQSTANAAAAEAADASTIFYNPAGL  |||||||||||||||||||||::||||||||||||||||||||||||||||||||||||| a989  MTPSALKKTVLLLGTAFAAASAQASGYHFGTQSVNAQSTANAAAAEAADASTIFYNPAGL          10        20        30        40        50        60          70        80        90       100       110       120 m989.pep  TKLDSSQISVNANIVLPSIHYEADSATDFTGLPVQGSKSGKITKTTVAPHIYGAYKVNDN  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a989  TKLDSSQISVNANIVLPSIHYEADSATDFTGLPVQGSKSGKITKTTVAPHIYGAYKVNDN          70        80        90       100       110       120         130       140       150       160       170       180 m989.pep  LTVGLGVYVPFGSATEYEKDSVLRHNINKLGLTSIAVEPVAAWKLNDRHSFGAGIIAQHT  ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||| a989  LTVGLGVYVPFGSATEYEKDSVLRHNINKLGLTSIAVEPVAAWKLNERHSFGAGIIAQHT         130       140       150       160       170       180         190       200       210       220       230       240 m989.pep  SAELRKYADWGIKSKAEILTAKPPKPNGVAEAAKIQADGHADVKGSDWGFGYQLAWMWDI  ||||||||||||  ||: |   ||:|:   :||:|:|||||||||||||||||||||||| a989  SAELRKYADWGIMEKAKALKETPPNPT---KAAQIKADGHADVKGSDWGFGYQLAWMWDI         190       200          210       220       230         250       260       270        280       290      299 m989.pep  NDRARVGVNYRSKVSHTLKGDAEWAADGAAAKAMW-STMLAANGYTANEKARVKIVTPES  ||||||||||||||||||||||||||| | || :| :: ||  ||| :|||||||||||| a989  NDRARVGVNYRSKVSHTLKGDAEWAADDAMAKQLWDANKLALLGYTPSEKARVKIVTPES  240       250       260       270       280       290300       310       320       330       340       350      359 m989.pep  LSVHGMYKVSDKADLFGDVTWTRHSRFDKAELVFEKEKTVVKGKSDRTTITPNWRNTYKV  |||||||||||||||||||||||||||||||||||||||:|:|||||||||||||||||| a989  LSVHGMYKVSDKADLFGDVTWTRHSRFDKAELVFEKEKTIVNGKSDRTTITPNWRNTYKV  300       310       320       330       340       350360      370       380       390       400       410      419 m989.pep  GFGGSYQISEPLQLRAGIAFDKSPVRNADYRMNSLPDGNRIWFSAGMKYHIGKNHVVDAA  |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a989  GFGGSYQISEPLQLRAGIAFDKSPVRNADYRMNSLPDGNRIWFSAGMKYHIGKNHVVDAA  360       370       380       390       400       410420     430       440       450       460 m989.pep  YTHIHINDTSYRTAKASGNDVDSKGASSARFKNHADIIGLQYTYKFKX  |||||||||||||||||||||||||||||||||||||||||||||||| a989  YTHIHINDTSYRTAKASGNDVDSKGASSARFKNHADIIGLQYTYKFKX  420     430       440       450       460The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2991>:

m990.seq 1 ATGTTCAGAG CTCAGCTTGG TTCAAATACT CGTTCTACCA AAATCGGCGA 51CGATGCCGAT TTTTCATTTT CAGACAAGCC GAAACCCGGC ACTTCCCATT 101 ATTTTTCCAGCGGTAAAACC GATCAAAATT CATCCGAATA TGGGTATGAC 151 GAAATCAATA TCCAAGGTAAAAATTACAAT AGCGGCATCC TCGCCGTCGA 201 TAATATGCCC GTTGTCAAAA AATATATTACAGAGAAGTAT GGGGCTGATT 251 TAAAGCAGGC GGTTAAAAGT CAATTACAGG ATTTATACAAAACAAGACCG 301 GAAGCTTGGG CAGAAAATAA AAAACGGACT GAGGAGGCGT ATATAGCACA351 GTTTGGAACA AAATTTAGTA CGCTCAAACA GACGATGCCC GATTTAATTA 401ATAAATTGGT AGAAGATTCC GTACTCACTC CTCATAGTAA TACATCACAG 451 ACTAGTCTCAACAACATCTT CAATAAAAAA TTACACGTCA AAATCGAAAA 501 CAAATCCCAC GTCGCCGGACAGGTGTTGGA ACTGACCAAG ATGACGCTGA 551 AAGATTCCCT TTGGGAACCG CGCCGCCATTCCGACATCCA TACGCTGGAA 601 ACTTCCGATA ATGCCCGCAT CCGCCTGAAC ACGAAAGATGAAAAACTGAC 651 CGTCCATAAG GATTATGCGG GCGGCGCGGA TTTCCTGTTC GGCTACGACG701 TGCGGGAGTC GGACGAACCC GCCCTGACCT TTGAAGACAA AGTCAGCGGA 751CAATCCGGCG TGGTTTTGGA ACGCCGGCCG GAAAATCTGA AAACGCTCGA 801 CGGGCGCAAACTGATTGCGG CAAAAACGGC GGATTCCGGT TCGTTTGCGT 851 TTAAACAAAA TTACCGGCAGGGACTGTACG AATTATTGCT CAAGCAATGC 901 GAAGGCGGAT TTTGCTTGGG CGTGCAGCGTTTGGCTATCC CCGAGGCGGA 951 AGCGGTTTTA TATGCCCAAC AGGCTTATGC GGCAAATACTTTGTTTGGGC 1001 TGCGTGCCGC CGACAGGGGC GACGACGTGT ATGCCGCCGA TCCGTCCCGT1051 CAAAAATTGT GGCTGCGCTT CATCGGCGGC CGGTCGCATC AAAATATACG 1101GGGCGGCGCG GCTGCGGACG GGTGGCGCAA AGGCGTGCAA ATCGGCGGCG 1151 AGGTGTTTGTACGGCAAAAT GAAGGCAGCC GACTGGCAAT CGGCGTGATG 1201 GGCGGCAGGG CCGGCCAGCACGCATCAGTC AACGGCAAAG GCGGTGCGGC 1251 AGGCAGTGAT TTGTATGGTT ATGGCGGGGGTGTTTATGCT GCGTGGCATC 1301 AGTTGCGCGA TAAACAAACG GGTGCGTATT TGGACGGCTGGTTGCAATAC 1351 CAACGTTTCA AACACCGCAT CAATGATGAA AACCGTGCGG AACGCTACAA1401 AACCAAAGGT TGGACGGCTT CTGTCGAAGG CGGCTACAAC GCGCTTGTGG 1451CGGAAGGCAT TGTCGGAAAA GGCAATAATG TGCGGTTTTA CCTACAACCG 1501 CAGGCGCAGTTTACCTACTT GGGCGTAAAC GGCGGCTTTA CCGACAGCGA 1551 GGGGACGGCG GTCGGACTGCTCGGCAGCGG TCAGTGGCAA AGCCGCGCCG 1601 GCATTCGGGC AAAAACCCGT TTTGCTTTGCGTAACGGTGT CAATCTTCAG 1651 CCTTTTGCCG CTTTTAATGT TTTGCACAGG TCAAAATCTTTCGGCGTGGA 1701 AATGGACGGC GAAAAACAGA CGCTGGCAGG CAGGACGGCA CTCGAAGGGC1751 GGTTCGGTAT TGAAGCCGGT TGGAAAGGCC ATATGTCCGC ACGCATCGGA 1801TATGGCAAAA GGACGGACGG CGACAAAGAA GCCGCATTGT CGCTCAAATG 1851 GCTGTTTTGAThis corresponds to the amino acid sequence <SEQ ID 2992; ORF 990>:

m990.pep 1 MFRAQLGSNT RSTKIGDDAD FSFSDKPKPG TSHYFSSGKT DQNSSEYGYD 51EINIQGKNYN SGILAVDNMP VVKKYITEKY GADLKQAVKS QLQDLYKTRP 101 EAWAENKKRTEEAYIAQFGT KFSTLKQTMP DLINKLVEDS VLTPHSNTSQ 151 TSLNNIFNKK LHVKIENKSHVAGQVLELTK MTLKDSLWEP RRHSDIHTLE 201 TSDNARIRLN TKDEKLTVHK DYAGGADFLFGYDVRESDEP ALTFEDKVSG 251 QSGVVLERRP ENLKTLDGRK LIAAKTADSG SFAFKQNYRQGLYELLLKQC 301 EGGFCLGVQR LAIPEAEAVL YAQQAYAANT LFGLRAADRG DDVYAADPSR351 QKLWLRFIGG RSHQNIRGGA AADGWRKGVQ IGGEVFVRQN EGSRLAIGVM 401GGRAGQHASV NGKGGAAGSD LYGYGGGVYA AWHQLRDKQT GAYLDGWLQY 451 QRFKHRINDENRAERYKTKG WTASVEGGYN ALVAEGIVGK GNNVRFYLQP 501 QAQFTYLGVN GGFTDSEGTAVGLLGSGQWQ SRAGIRAKTR FALRNGVNLQ 551 PFAAFNVLHR SKSFGVEMDG EKQTLAGRTALEGRFGIEAG WKGHMSARIG 601 YGKRTDGDKE AALSLKWLF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2993>:

a990.seq 1 ATGTTCAGAG CTCAGCTTGG TTCAAATACT CGTTCTACCA AAATCGGCGA 51CGATGCCGAT TTTTCATTTT CAGACAAGCC GAAACCCGGC ACTTCCCATT 101 ATTTTTCCAGCGGTAAAACC GATCAAAATT CATCCGAATA TGGGTATGAC 151 GAAATCAATA TCCAAGGTAAAAACTACAAT AGCGGCATAC TCGCCGTCGA 201 TAATATGCCC GTTGTTAAGA AATATATTACAGATACTTAC GGGGATAATT 251 TAAAGGATGC GGTTAAGAAG CAATTACAGG ATTTATACAAAACAAGACCC 301 GAAGCTTGGG AAGAAAATAA AAAACGGACT GAGGAGGCGT ATATAGAACA351 GCTTGGACCA AAATTTAGTA TACTCAAACA GAAAAACCCC GATTTAATTA 401ATAAATTGGT AGAAGATTCC GTACTCACTC CTCATAGTAA TACATCACAG 451 ACTAGTCTCAACAACATCTT CAATAAAAAA TTACACGTCA AAATCGAAAA 501 CAAATCCCAC GTCGCCGGACAGGTGTTGGA ACTGACCAAG ATGACGCTGA 551 AAGATTCCCT TTGGGAACCG CGCCGCCATTCCGACATCCA TATGCTGGAA 601 ACTTCCGATA ATGCCCGCAT CCGCCTGAAC ACGAAAGATGAAAAACTGAC 651 CGTCCATAAA GCGTATCAGG GCGGTGCGGA TTTCCTGTTC GGCTACGACG701 TGCGGGAGTC GGACAAACCC GCCCTGACCT TTGAAGAAAA AGTCAGCGGA 751CAATCCGGCG TGGTTTTGGA ACGCCGGCCG GAAAATCTGA AAACGCTCGA 801 CGGGCGCAAACTGATTGCGG CGGAAAAGGC AGACTCTAAT TCGTTTGCGT 851 TTAAACAAAA TTACCGGCAGGGACTGTACG AATTATTGCT CAAGCAATGC 901 GAAGGCGGAT TTTGCTTGGG CGTGCAGCGTTTGGCTATCC CCGAGGCGGA 951 AGCGGTTTTA TATGCCCAAC AGGCTTATGC GGCAAATACTTTGTTCGGGC 1001 TGCGTGCCGC CGACAGGGGC GACGACGTGT ATGCCGCCGA TCCGTCCCGT1051 CAAAAATTGT GGCTGCGCTT CATCGGCGGC CGGTCGCATC AAAATATACG 1101GGGCGGCGCG GCTGCGGACG GGCGGCGCAA AGGCGTGCAA ATCGGCGGCG 1151 AGGTGTTTGTACGGCAAAAT GAAGGCAGCC GGCTGGCAAT CGGCGTGATG 1201 GGCGGCAGGG CTGGCCAGCACGCATCAGTC AACGGCAAAG GCGGTGCGGC 1251 AGGCAGTTAT TTGCATGGTT ATGGCGGGGGTGTTTATGCT GCGTGGCATC 1301 AGTTGCGCGA TAAACAAACG GGTGCGTATT TGGACGGCTGGTTGCAATAC 1351 CAACGTTTCA AACACCGCAT CAATGATGAA AACCGTGCGG AACGCTACAA1401 AACCAAAGGT TGGACGGCTT CTGTCGAAGG CGGCTACAAC GCGCTTGTGG 1451CGGAAGGCGT TGTCGGAAAA GGCAATAATG TGCGGTTTTA CCTGCAACCG 1501 CAGGCGCAGTTTACCTACTT GGGCGTAAAC GGCGGCTTTA CCGACAGCGA 1551 GGGGACGGCG GTCGGACTGCTCGGCAGCGG TCAGTGGCAA AGCCGCGCCG 1601 GCATTCGGGC AAAAACCCGT TTTGCTTTGCGTAACGGTGT CAATCTTCAG 1651 CCTTTTGCCG CTTTTAATGT TTTGCACAGG TCAAAATCTTTCGGCGTGGA 1701 AATGGACGGC GAAAAACAGA CGCTGGCAGG CAGGACGGCG CTCGAAGGGC1751 GGTTCGGCAT TGAAGCCGGT TGGAAAGGCC ATATGTCCGC ACGCATCGGA 1801TACGGCAAAA GGACGGACGG CGACAAAGAA GCCGCATTGT CGCTCAAATG 1851 GCTGTTTTGAThis corresponds to the amino acid sequence <SEQ ID 2994; ORF 990.a>:

a990.pep 1 MFRAQLGSNT RSTKIGDDAD FSFSDKPKPG TSHYFSSGKT DQNSSEYGYD 51EINIQGKNYN SGILAVDNMP VVKKYITDTY GDNLKDAVKK QLQDLYKTRP 101 EAWEENKKRTEEAYIEQLGP KFSILKQKNP DLINKLVEDS VLTPHSNTSQ 151 TSLNNIFNKK LHVKIENKSHVAGQVLELTK MTLKDSLWEP RRHSDIHMLE 201 TSDNARIRLN TKDEKLTVHK AYQGGADFLFGYDVRESDKP ALTFEEKVSG 251 QSGVVLERRP ENLKTLDGRK LIAAEKADSN SFAFKQNYRQGLYELLLKQC 301 EGGFCLGVQR LAIPEAEAVL YAQQAYAANT LFGLRAADRG DDVYAADPSR351 QKLWLRFIGG RSHQNIRGGA AADGRRKGVQ IGGEVFVRQN EGSRLAIGVM 401GGRAGQHASV NGKGGAAGSY LHGYGGGVYA AWHQLRDKQT GAYLDGWLQY 451 QRFKHRINDENRAERYKTKG WTASVEGGYN ALVAEGVVGK GNNVRFYLQP 501 QAQFTYLGVN GGFTDSEGTAVGLLGSGQWQ SRAGIRAKTR FALRNGVNLQ 551 PFAAFNVLHR SKSFGVEMDG EKQTLAGRTALEGRFGIEAG WKGHMSARIG 601 YGKRTDGDKE AALSLKWLF* m990/a990 96.0% identityin 619 aa overlap        10        20        30        40        50        60 m990.pepMFRAQLGSNTRSTKIGDDADFSFSDKPKPGTSHYFSSGKTDQNSSEYGYDEINIQGKNYN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a990MFRAQLGSNTRSTKIGDDADFSFSDKPKPGTSHYFSSGKTDQNSSEYGYDEINIQGKNYN        10        20        30        40        50        60        70        80        90       100       110       120 m990.pepSGILAVDNMPVVKKYITEKYGADLKQAVKSQLQDLYKTRPEAWAENKKRTEEAYIAQFGT|||||||||||||||||: || :||:|||:||||||||||||| ||||||||||| |:| a990SGILAVDNMPVVKKYITDTYGDNLKDAVKKQLQDLYKTRPEAWEENKKRTEEAYIEQLGP        70        80        90       100       110       120       130       140       150       160       170       180 m990.pepKFSTLKQTMPDLINKLVEDSVLTPHSNTSQTSLNNIFNKKLHVKIENKSHVAGQVLELTK||| |||  ||||||||||||||||||||||||||||||||||||||||||||||||||| a990KFSILKQKNPDLINKLVEDSVLTPHSNTSQTSLNNIFNKKLHVKIENKSHVAGQVLELTK       130       140       150       160       170       180       190       200       210       220       230       240 m990.pepMTLKDSLWEPRRHSDIHTLETSDNARIRLNTKDEKLTVHKDYAGGADFLFGYDVRESDEP||||||||||||||||| |||||||||||||||||||||| | |||||||||||||||:| a990MTLKDSLWEPRRHSDIHMLETSDNARIRLNTKDEKLTVHKAYQGGADFLFGYDVRESDKP       190       200       210       220       230       240       250       260       270       280       290       300 m990.pepALTFEDKVSGQSGVVLERRPENLKTLDGRKLIAAKTADSGSFAFKQNYRQGLYELLLKQC|||||:||||||||||||||||||||||||||||: |||:|||||||||||||||||||| a990ALTFEEKVSGQSGVVLERRPENLKTLDGRKLIAAEKADSNSFAFKQNYRQGLYELLLKQC       250       260       270       280       290       300       310       320       330       340       350       360 m990.pepEGGFCLGVQRLAIPEAEAVLYAQQAYAANTLFGLRAADRGDDVYAADPSRQKLWLRFIGG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a990EGGFCLGVQR LAIPEAEAVL YAQQAYAANT LFGLRAADRG DDVYAADPSR QKLWLRFIGG       310       320       330       340       350       360       370       380       390       400       410       420 m990.pepRSHQNIRGGAAADGWRKGVQIGGEVFVRQNEGSRLAIGVMGGRAGQHASVNGKGGAAGSD|||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| a990RSHQNIRGGAAADGRRKGVQIGGEVFVRQNEGSRLAIGVMGGRAGQHASVNGKGGAAGSY       370       380       390       400       410       420       430       440       450       460       470       480 m990.pepLYGYGGGVYAAWHQLRDKQTGAYLDGWLQYQRFKHRINDENRAERYKTKGWTASVEGGYN|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a990LHGYGGGVYAAWHQLRDKQTGAYLDGWLQYQRFKHRINDENRAERYKTKGWTASVEGGYN       430       440       450       460       470       480       490       500       510       520       530       540 m990.pepALVAEGIVGKGNNVRFYLQPQAQFTYLGVNGGFTDSEGTAVGLLGSGQWQSRAGIRAKTR||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||| a990ALVAEGVVGKGNNVRFYLQPQAQFTYLGVNGGFTDSEGTAVGLLGSGQWQSRAGIRAKTR       490       500       510       520       530       540       550       560       570       580       590       600 m990.pepFALRNGVNLQPFAAFNVLHRSKSFGVEMDGEKQTLAGRTALEGRFGIEAGWKGHMSARIG|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| a990FALRNGVNLQPFAAFNVLHRSKSFGVEMDGEKQTLAGRTALEGRFGIEAGWKGHMSARIG       550       560       570       580       590       600       610       620 m990.pep YGKRTDGDKEAALSLKWLFX ||||||||||||||||||||a990 YGKRTDGDKE AALSLKWLFX        610       620The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 2995>:

g992.seq 1 ATGTTCAGAC GGCATCGGCA TTTGAAAAAT ATGCAGATTA AAAAAATCAT 51GAAATGGCTT CCCGTCGCCC TGTCGCTTTT GGGCGCGTTG GGTTATACGG 101 GATATGACAGTGAGGCGGTG CGGACGGCGG TTGCCGTACT CGACGTACTC 151 GGCACTGCAG GGGACGTGGGTTTCGACGCG CCCGTTCGCC GACGGGCATC 201 GGCGAAATCC GGCCACAGCT ACACAGGCACGGTGTCCAAA GTCTATGACG 251 GCGATACCCT TCACGTCATC GACGGCGACG GCGCGAAACATAAAATTCGG 301 ATGGCGTATA TCGACGCACC GGAGATGAAA CAGGCTTACG GTACACGTTC351 GCGCGACAAC CTGCGCGCGG CGGCGGAGGG TAGGAAAGTC AGTGTACGTG 401TGTTTGAAAC CGACCGCTAT CAGCGCGAAG TGGCGCAGGT ATCCGCCGGC 451 AAAACCGATTTGAACCTGAT GCAGGTGCAG GACGGGGCGG CGTGGCATTA 501 TAAAAGTTAT GCTAAAGAACAGCAGGATAA GGCGGATTTT GCCGACTATG 551 CCGACGCTCA AATTCAGGCG GAAAGGGAACGCAAAGGATT GTGGAAAGCT 601 AAAAATCCGC AAGCGCCGTG GGCGTACCGC CGGGCAGGCAGGAGCGGCGG 651 GGGCAATAAG GATTGGATGG ATTCCGTGGG CGAATGGTTG GGCATTTGGT701 AAThis corresponds to the amino acid sequence <SEQ ID 2996 ORF 992.ng>:

g992.pep 1 MFRRHRHLKN MQIKKIMKWL PVALSLLGAL GYTGYDSEAV RTAVAVLDVL 51GTAGDVGFDA PVRRRASAKS GHSYTGTVSK VYDGDTLHVI DGDGAKHKIR 101 MAYIDAPEMKQAYGTRSRDN LRAAAEGRKV SVRVFETDRY QREVAQVSAG 151 KTDLNLMQVQ DGAAWHYKSYAKEQQDKADF ADYADAQIQA ERERKGLWKA 201 KNPQAPWAYR RAGRSGGGNK DWMDSVGEWLGIW*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2997>:

m992.seq 1 ATGTTCAGAC GGCATCGGCA TTTGAAAAAT ATGCAGATTA AAAAAATCAT 51GAAATGGCTT CCCGTCGCCC TGTCGCTTTT GGGTGCGTTG GGTTATACGG 101 GGTACGGCAGCGAGGCGGTG CGGACGGCGG TTGCCGTACT CGACGTACTC 151 GGCGCGGCAG GGGACGCGGGTTCCGACGCG CCCGCCCGCC GCCGAGCATC 201 GGCGAAATCC GGCCACCGCT ACACAGGCACGGTGTCCAAA GTCTATGACG 251 GCGACACCCT TCACGTTATC GACGGCGACG GCGCGAAACACAAAATCCGG 301 ATGGCGTATA TCGACGCGCC GGAGATGAAA CAGGCTTACG GCACGCGTTC351 GCGCGACAAC CTGCGCGCGG CGGCGGAAGG CAGGAAAGTC AGCGTGCGCG 401TGTTCGATAC CGACCGCTAC CAGCGCGAAG TGGCGCAGGT TTCTGTCGGC 451 AAAACCGATTTGAACCTGAT GCAGGTGCAG GACGGGGCGG CGTGGCATTA 501 TAAAAGTTAT GCTAAAGAACAGCAGGATAA GGCGGATTTT GCCGATTATG 551 CCGACGCTCA AATTCAGGCG GAAAGGGAACGCAAAGGATT GTGGAAAGCT 601 AAAAATCCGC AAGCGCCGTG GGCGTACCGC CGAGCAGGCAGGAGCGGCGG 651 GGGCAATAAG GATTGGATGG ATGCCGTGGG CGAATGGTTG GGCATTTGGT701 AAThis corresponds to the amino acid sequence <SEQ ID 2998; ORF 992>:

m992.pep 1 MFRRHRHLKN MQIKKIMKWL PVALSLLGAL GYTGYGSEAV RTAVAVLDVL 51GAAGDAGSDA PARRRASAKS GHRYTGTVSK VYDGDTLHVI DGDGAKHKIR 101 MAYIDAPEMKQAYGTRSRDN LRAAAEGRKV SVRVFDTDRY QREVAQVSVG 151 KTDLNLMQVQ DGAAWHYKSYAKEQQDKADF ADYADAQIQA ERERKGLWKA 201 KNPQAPWAYR RAGRSGGGNK DWMDAVGEWLGIW*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 992 shows 96.1% identity over a 233 aa overlap with a predicted ORF(ORF 992) from N. gonorrhoeae

m992/g992 96.1% identity in 233 aa overlap        10        20        30        40        50        60 m992.pepMFRRHRHLKNMQIKKIMKWLPVALSLLGALGYTGYGSEAVRTAVAVLDVLGAAGDAGSDA||||||||||||||||||||||||||||||||||| |||||||||||||||:|||:| || g992MFRRHRHLKNMQIKKIMKWLPVALSLLGALGYTGYDSEAVRTAVAVLDVLGTAGDVGFDA        10        20        30        40        50        60        70        80        90       100       110       120 m992.pepPARRRASAKSGHRYTGTVSKVYDGDTLHVIDGDGAKHKIRMAYIDAPEMKQAYGTRSRDN|:|||||||||| ||||||||||||||||||||||||||||||||||||||||||||||| g992PVRRRASAKSGHSYLGTVSKVYDGDTLHVIDGDGAKHKIRMAYIDAPEMKQAYGTRSRDN        70        80        90       100       110       120       130       140       150       160       170       180 m992.pepLRAAAEGRKVSVRVFDTDRYQREVAQVSVGKTDLNLMQVQDGAAWHYKSYAKEQQDKADF|||||||||||||||:||||||||||||:||||||||||||||||||||||||||||||| g992LRAAAEGRKVSVRVFETDRYQREVAQVSAGKTDLNLMQVQDGAAWHYKSYAKEQQDKADF       130       140       150       160       170       180       190       200       210       220       230 m992.pepADYADAQIQAERERKGLWKAKNPQAPWAYRRAGRSGGGNKDWMDAVGEWLGIWX||||||||||||||||||||||||||||||||||||||||||||:||||||||| g992ADYADAQIQAERERKGLWKAKNPQAPWAYRRAGRSGGGNKDWMDSVGEWLGIWX       190       200       210       220       230The following partial DNA sequence was identified in N. meningitidis<SEQ ID 2999>:

a992.seq 1 ATGTTCAGAC GGCATCGGCA TTTGAAAAAT ATGCAGATTA AAAAAATCAT 51GAAATGGCTT CCCGTCGCCT TGTCGCTTTT GGGTGCGTTG GGTTATACGG 101GGTACGGCAG CGAGGCGGTG CGGACGGCGG TTGCCGTACT CGACGTACTC 151GGCGCGGCAG GGGACGCGGG TTCCGACGCG CCCGCCCGCC GCCGAGCATC 201GGCGAAATCC GGCCACCGCT ACACAGGCAC GGTGTCCAAA GTCTATGACG 251GCGACACCCT TCACGTTATC GACGGCGACG GCGCGAAACA CAAAATCCGG 301ATGGCGTATA TCGACGCGCC GGAGATGAAA CAGGCTTACG GCACGCGTTC 351GCGCGACAAC CTGCGCGCGG CGGCGGAAGG CAGGAAAGTC AGCGTCCGCG 401TGTTCGACAC CGACCGCTAC CAGCGCGAAG TGGCGCAGGT TTCTGTCGGC 451AAAACCGATT TGAACCTGAT GCAGGTGCAG GACGGGGCGG CGTGGCATTA 501TAAAAGTTAT GCTAAAGAAC AGCAGGATAA GGCGGATTTT GCCGATTATG 551CCGACGCTCA AATTCAGGCG GAAAGGGAAC GCAAAGGATT GTGGAAAGCT 601AAAAATCCGC AAGCGCCGTG GGCGTACCGC CGGGCAGGCA GGAGCGGCGG 651GGGCAATAAG GATTGGATGG ATGCCGTGGG CGAATGGTTG GGCATTTGGT 701 AAThis corresponds to the amino acid sequence <SEQ ID 3000; ORF 992.a>:

a992.pep 1  MFRRHRHLKN MQIKKIMKWL PVALSLLGAL GYTGYGSEAV RTAVAVLDVL 51 GAAGDAGSDA PARRRASAKS GHRYTGTVSK VYDGDTLHVI DGDGAKHKIR 101MAYIDAPEMK QAYGTRSRDN LRAAAEGRKV SVRVFDTDRY QREVAQVSVG 151KTDLNLMQVQ DGAAWHYKSY AKEQQDKADF ADYADAQIQA ERERKGLWKA 201KNPQAPWAYR RAGRSGGGNK DWMDAVGEWL GIW*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 992 shows 100.0% identity over a 233 aa overlap with a predicted ORF(ORF 992) from N. meningitidis

a992/m992 100.0% identity in 233 aa overlap        10        20        30        40        50        60 a992.pepMFRRHRHLKNMQIKKIMKWLPVALSLLGALGYTGYGSEAVRTAVAVLDVLGAAGDAGSDA|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m992MFRRHRHLKNMQIKKIMKWLPVALSLLGALGYTGYGSEAVRTAVAVLDVLGAAGDAGSDA        10        20        30        40        50        60        70        80        90       100       110       120 a992.pepPARRRASAKSGHRYTGTVSKVYDGDTLHVIDGDGAKHKIRMAYIDAPEMKQAYGTRSRDN|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m992PARRRASAKSGHRYTGTVSKVYDGDTLHVIDGDGAKHKIRMAYIDAPEMKQAYGTRSRDN        70        80        90       100       110       120       130       140       150       160       170       180 a992.pepLRAAAEGRKVSVRVFDTDRYQREVAQVSVGKTDLNLMQVQDGAAWHYKSYAKEQQDKADF|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m992LRAAAEGRKVSVRVFDTDRYQREVAQVSVGKTDLNLMQVQDGAAWHYKSYAKEQQDKADF       130       140       150       160       170       180       190       200       210       220       230 a992.pepADYADAQIQAERERKGLWKAKNPQAPWAYRRAGRSGGGNKDWMDAVGEWLGIWX|||||||||||||||||||||||||||||||||||||||||||||||||||||| m992ADYADAQIQAERERKGLWKAKNPQAPWAYRRAGRSGGGNKDWMDAVGEWLGIWX       190       200       210       220       230The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3001>:

g993.seq 1 CTGAAAGTCG TATTGGGCAG TTTTCAAGGC CCTTTGGATC TGCTGCTCTA 51CCTTATCCGC AAGCAGAACA TCGATGTTCT CGATATTCCG ATGGTGGAAA 101TTACCGGGCA GTATCTGCAC TATATTGCCC AAATGGAAGC CTATCAGTTT 151GATTTGGCGG CGGAATATCT TTTGATGGCG GCAATGCTGA TTGAAATCAA 201ATCGCGCCTG CTGCTGCCGC GTACCGAAGC CGTCGAAGAC GAAGAGGCCG 251ACCCGCGTGC CGAGTTGGTG CGCCGTCTGC TTGCCTACGA GCAAATGAAA 301CTGGCGGCGC AGGGTTTGGA CGCGCTGCCG CGTGCGGGAC GGGATTTCGC 351GTGGGCTTAC CTGCCGCTGG AAATTGCAGC CGAGACGAAG CTGCCCGAGG 401TTTACATCGC CGATTTGATG CAGGCATGGT TGGGCATTCT TTCTCGGGCA 451AAACATACGC GCAGCCACGA AGTAATCCAA GAAACCCTTT CCGTGCGCGC 501GCAAATGACG GCAATCCTGC GCCGTTTGAA CGAACACGGG ATATGCAGGT 551TTCACGCCCT GTTCAATCCC GAACAGGGCG CGGCTTACGT GATCGTCAAC 601TTCATCGCCC TGTTGGAGCT TGCCAAAGAA GGATTGGTCG GAATCGTACA 651GGAAGACGGT TTCGGAGAAA TCCGAATCAG CCTCAATCAT GAGGGGGCGC 701ATTCAGACGG CATTTTCGGC ACACGGGGCG GGCGCGATGT GTTCTAAThis corresponds to the amino acid sequence <SEQ ID 3002 ORF 993.ng>:

g993.pep 1  LKVVLGSFQG PLDLLLYLIR KQNIDVLDIP MVEITGQYLH YIAQMEAYQF 51DLAAEYLLMA AMLIEIKSRL LLPRTEAVED EEADPRAELV RRLLAYEQMK 101LAAQGLDALP RAGRDFAWAY LPLEIAAETK LPEVYIADLM QAWLGILSRA 151KHTRSHEVIQ ETLSVRAQMT AILRRLNEHG ICRFHALFNP EQGAAYVIVN 201FIALLELAKE GLVGIVQEDG FGEIRISLNH EGAHSDGIFG TRGGRDVF*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3003>:

m993.seq 1 TTGAAAGTCG TATTGGGCAG CTTCCAAGGC CCTTTGGATC TACTGCTGTA 51TCTGATCCGC AAACAGAATA TCGACGTACT GGATATTCCG ATGGTGAAGA 101TTACCGAGCA GTATCTGCAC TACATCGCCC AAATAGAAAC CTATCAGTTT 151GATTTGGCGG CGGAATATCT TTTGATGGCA GCAATGCTGA TTGAAATCAA 201ATCGCGCCTG CTGCTGCCGC GTACCGAAAC CGTCGAAGAC GAAGAAGCCG 251ACCCGCGTGC CGAGTTGGTG CGCCGCCTGC TGGCTTACGA ACAGATGAAG 301CTGGCGGCGC AGGGTTTGGA CGCGCTGCCC CGAGCCGGAC GGGATTTCGC 351GTGGGCTTAC CTGCCGCTGG AAATTGCCGT CGAAGCCAAG CTGCCCGAAG 401TCTATATTAC CGACTTGACG CAAGCGTGGC TGGGTATTTT GTCTCGGGCA 451AAACACACGC GCAGCCACGA AGTAATCAAA GAAACCATCT CCGTGCGCGC 501GCAAATGACG GCAATCCTGC GCCGTTTGAA CGGACACGGA ATATGCAGGT 551TTCACGACCT GTTCAATCCC AAACAGGGCG CGGCTTACGT GGTCGTCAAC 601TTCATCGCAC TGTTGGAGCT TGCCAAAGAA GGATTGGTCA GAATCGTGCA 651GGAAGACGGT TTCGGAGAAA TCCGAATCAG CCTCAATCAT GAGGGGGCGC 701ATTCAGACGG CATTTCCGGC ACACGAGGCG GGCGCGATGT GTTCTAAThis corresponds to the amino acid sequence <SEQ ID 3004; ORF 993>:

m993.pep 1 LKVVLGSFQG PLDLLLYLIR KQNIDVLDIP MVKITEQYLH YIAQIETYQF 51DLAAEYLLMA AMLIEIKSRL LLPRTETVED EEADPRAELV RRLLAYEQMK 101LAAQGLDALP RAGRDFAWAY LPLEIAVEAK LPEVYITDLT QAWLGILSRA 151KHTRSHEVIK ETISVRAQMT AILRRLNGHG ICRFHDLFNP KQGAAYVVVN 201FIALLELAKE GLVRIVQEDG FGEIRISLNH EGAHSDGISG TRGGRDVF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 993 shows 93.1% identity over a 248 aa overlap with a predicted ORF(ORF 993) from N. gonorrhoeae

m993/g993 93.1% identity in 248 aa overlap        10        20        30        40        50        60 m993.pepLKVVLGSFQGPLDLLLYLIRKQNIDVLDIPMVKITEQYLHYIAQIETYQFDLAAEYLLMA||||||||||||||||||||||||||||||||:|| ||||||||:|:||||||||||||| g993LKVVLGSFQGPLDLLLYLIRKQNIDVLDIPMVEITGQYLHYIAQMEAYQFDLAAEYLLMA        10        20        30        40        50        60        70        80        90       100       110       120 m993.pepAMLIEIKSRLLLPRTETVEDEEADPRAELVRRLLAYEQMKLAAQGLDALPRAGRDFAWAY||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||| g993AMLIEIKSRLLLPRTEAVEDEEADPRAELVRRLLAYEQMKLAAQGLDALPRAGRDFAWAY        70        80        90       100       110       120       130       140       150       160       170       180 m993.pepLPLEIAVEAKLPEVYILDLTQAWLGILSRAKHTRSHEVIKETISVRAQMTAILRRLNGHG||||||:|:|||||||:|| |||||||||||||||||||:||:|||||||||||||| || g993LPLEIAAETKLPEVYIADLMQAWLGILSRAKHTRSHEVIQELLSVRAQMTAILRRLNEHG       130       140       150       160       170       180       190       200       210       220       230       240 m993.pepICRFHDLFNPKQGAAYVVVNFIALLELAKEGLVRIVQEDGFGEIRISLNHEGAHSDGISG |||||||||:||||||:||||||||||||||| |||||||||||||||||||||||| | g993ICRFHALFNPEQGAAYVIVNFIALLELAKEGLVGIVQEDGFGEIRISLNHEGAHSDGIFG       190       200       210       220       230       240       249m993.pep TRGGRDVFX ||||||||| g993 TRGGRDVFXThe following partial DNA sequence was identified in N. meningitidis<SEQ ID 3005>:

a993.seq 1 CTGAAAGTCG TATTGAGCAG TTTTCAAGGC CCTTTGGATC TGCTGCTCTA 51CCTTATCCGC AAGCAGAACA TCGATGTTCT CGATATTCCG ATGGTGAAGA 101TTACCGAACA GTATCTGCAC TACATCGCCC AAATAGAAAC CTATCAGTTT 151GATTTGGCGG CGGAATATCT TTTGATGGCA GCAATGCTGA TTGAAATCAA 201ATCGCGCCTG CTGCTGCCGC GTACCGAAAC CGTCGAAGAC GAAGAAGCCG 251ACCCGCGTGC CGAGTTGGTG CGCCGCCTGC TGGCTTACGA GCAGATGAAG 301CTGGCGGCAC AAGGGTTGGA TGCGCTTCCT CGTGCGGGCC GGGATTTCGC 351ATGGGCATAC CTGCCACTGG AAATTGCCGT CGAAGCCAAG CTGCCCGAAG 401TCTATATTAC CGACTTGACG CAGGCGTGGC TGAGTATTTT GTCTCGGGCA 451AAACATACGC GCAGCCACGA AGTTATCAAA GAAACCATCT CCGTGCGCGC 501GCAAATGACG GCAATCCTGC GCCGTTTGAA CAAACACGGG ATATGCAGGT 551TTCACGACCT GTTCAATCCC GAACAGGGCG CGGCTTACGT GGTCGTCAAC 601TTCATCGCAC TGTTGGAGCT TGCCAAAGAA GGTTTGGTCG GAATCGTACA 651GGAAGTCGGT TTCGGAGAAA TCCGAATCAG CCTCAATCAT GAGGGGGCGC 701ATTCAGACGG CATTTCCGGC ACACGGGGCG GGCGCGATGT GTTCTAAThis corresponds to the amino acid sequence <SEQ ID 3006; ORF 993.a>:

a993.pep 1 LKVVLSSFQG PLDLLLYLIR KQNIDVLDIP MVKITEQYLH YIAQIETYQF 51DLAAEYLLMA AMLIEIKSRL LLPRTETVED EEADPRAELV RRLLAYEQMK 101LAAQGLDALP RAGRDFAWAY LPLEIAVEAK LPEVYITDLT QAWLSILSRA 151KHTRSHEVIK ETISVRAQMT AILRRLNKHG ICRFHDLFNP EQGAAYVVVN 201FIALLELAKE GLVGIVQEVG FGEIRISLNH EGAHSDGISG TRGGRDVF*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 993 shows 97.6% identity over a 248 aa overlap with a predicted ORF(ORF 993) from N. meningitidis

a993/m993 97.6% identity in 248 aa overlap        10        20        30        40        50        60 a993.pepLKVVLSSFQGPLDLLLYLIRKQNIDVLDIPMVKITEQYLHYIAQIETYQFDLAAEYLLMA|||||:||||||||||||||||||||||||||||||||||||||||||||||||||||| | m993LKVVLGSFQGPLDLLLYLIRKQNIDVLDIPMVKITEQYLHYIAQIETYQFDLAAEYLLMA        10        20        30        40        50        60        70        80        90       100       110       120 a993.pepAMLIEIKSRLLLPRTETVEDEEADPRAELVRRLLAYEQMKLAAQGLDALPRAGRDFAWAY|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m993AMLIEIKSRLLLPRTETVEDEEADPRAELVRRLLAYEQMKLAAQGLDALPRAGRDFAWAY        70        80        90       100       110       120       130       140       150       160       170       180 a993.pepLPLEIAVEAKLPEVYILDLTQAWLSILSRAKHTRSHEVIKETISVRAQMTAILRRLNKHG||||||||||||||||||||||||:|||||||||||||||||||||||||||||||| || m993LPLEIAVEAKLPEVYILDLTQAWLGILSRAKHTRSHEVIKETISVRAQMTAILRRLNGHG       130       140       150       160       170       180       190       200       210       220       230       240 a993.pepICRFHDLFNPEQGAAYVVVNFIALLELAKEGLVGIVQEVGFGEIRISLNHEGAHSDGISG||||||||||:|||||||||||||||||||||| |||| ||||||||||||||||||||| m993ICRFHDLFNPKQGAAYVVVNFIALLELAKEGLVRIVQEDGFGEIRISLNHEGAHSDGISG       190       200       210       220       230       240       249a993.pep TRGGRDVFX ||||||||| m993 TRGGRDVFXThe following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3007>:

g996.seq 1 ATGAACAGAA GAACCTTCCT CCTCGGCGCA GGCGCGTTGC TTCTTACCGC 51CTGCGGCAGA AAATCCGCCC GAACCCACGC CAAAATTCCC GAAGGAAGCA 101CCGTGCTTGC CTTGGGCGAT TCGCTCACCT TCGGCTACGG AGCAAACCCC 151GGCGAATCCT ACCCCGCGCA ACTGCAAAAA CTGACGGGTT GGAATATTGT 201CAACGGCGGC GTATCGGGCG ATACGTCCGC GCAAGCCCTA TCGCGCCTGC 251CCGCGCTGTT GGCACGCAAA CCCAAGCTTG TGATTGTCGG CATAGGCGGC 301AACGACTTTC TGCGCAAAGT TCCCGAGGAG CAGACCCGCG CCAATATCGC 351GAAAATCATC GAAACCGTGC AAAAGGAAAA CATTCCCGCC GTCCTCGTCG 401GCGTGCCGCA CATCACACTG GGCGCGTTGT TCGGGCATTT GAGCGACCAT 451CCGCTGTATG AGGATTTGTC CGAGGAATAC GGCATTCCGT TGTTCGGCGG 501CGCGTGGGCG GAAATTTTGG GCAATAATAA TCTGAAATCC GACCAAATCC 551ACGCCAACGG CAAAGGCTAT CGGAAATTCG CCGAAAATTT GAATCAATTT 601TTGAGAAAAC ATGGGTTTAG ATAAThis corresponds to the amino acid sequence <SEQ ID 3008 ORF 996.ng>:

g996.pep 1 MNRRTFLLGA GALLLTACGR KSARTHAKIP EGSTVLALGD SLTFGYGANP 51GESYPAQLQK LTGWNIVNGG VSGDTSAQAL SRLPALLARK PKLVIVGIGG 101NDFLRKVPEE QTRANIAKII ETVQKENIPA VLVGVPHITL GALFGHLSDH 151PLYEDLSEEY GIPLFGGAWA EILGNNNLKS DQIHANGKGY RKFAENLNQF 201 LRKHGFR*The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3009>:

m996.seq 1 ATGAACAGAA GAACCTTCCT CCTCGGCGCA GGCGCGTTGC TGCTTACCGC 51CTGCGGCAGA AAATCCGCCC GAACCCACGC CAAAATTCCC GAAGGAAGCA 101CCGTACTTGC CTTGGGCGAT TCGCTTACCT TCGGCTACGG CGCAAACCCT 151GGCGAATCCT ACCCCGCGCA ACTGCAAAAA CTGACGGGTT GGAATATTGT 201CAACGGCGGC GTATCGGGCG ATACATCTGC CCAAGCCCTG TCGCGCCTGC 251CCGCGCTGTT GGCACGCAAA CCCAAGCTTG TGATTGTCGG CATAGGCGGC 301AACGACTTTC TGCGCAAAGT TCCCAAGGAG CAGACCCGCG CCAATATCGC 351GAAAATCATC GAAACCGTGC AGAAGGAAAA CATCCCCGCC GTCCTCGTCG 401GCGTGCCGCA CATCACACTG GGTGCGTTGT TCGGGCATTT GAGCGATCAT 451CCGCTGTATG AGGATTTGTC CGAGGAATAC GGCATTCCGC TGTTCGGCGG 501CGCGTGGGCG GAAATTTTGG GCGATAATAA TCTGAAATCC GACCAAATCC 551ACGCCAACGG CAAAGGCTAT CGGAAATTTG CCGAAGATTT GAATCAATTT 601TTGAGAAAAC AGGGGTTTAG ATAAThis corresponds to the amino acid sequence <SEQ ID 3010; ORF 996>:

m996.pep 1 MNRRTFLLGA GALLLTACGR KSARTHAKIP EGSTVLALGD SLTFGYGANP 51GESYPAQLQK LTGWNIVNGG VSGDTSAQAL SRLPALLARK PKLVIVGIGG 101NDFLRKVPKE QTRANIAKII ETVQKENIPA VLVGVPHITL GALFGHLSDH 151PLYEDLSEEY GIPLFGGAWA EILGDNNLKS DQIHANGKGY RKFAEDLNQF 201 LRKQGFRComputer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 996 shows 98.1% identity over a 207 aa overlap with a predicted ORF(ORF 996) from N. gonorrhoeae

m996/g996 98.1% identity in 207 aa overlap        10        20        30        40        50        60 m996.pepMNRRTFLLGAGALLLTACGRKSARTHAKIPEGSTVLALGDSLTFGYGANPGESYPAQLQK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| g996MNRRTFLLGAGALLLTACGRKSARTHAKIPEGSTVLALGDSLTFGYGANPGESYPAQLQK        10        20        30        40        50        60        70        80        90       100       110       120 m996.pepLTGWNIVNGGVSGDTSAQALSRLPALLARKPKLVIVGIGGNDFLRKVPKEQTRANIAKII||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||| g996LTGWNIVNGGVSGDTSAQALSRLPALLARKPKLVIVGIGGNDFLRKVPEEQTRANIAKII        70        80        90       100       110       120       130       140       150       160       170       180 m996.pepETVQKENIPAVLVGVPHITLGALFGHLSDHPLYEDLSEEYGIPLFGGAWAEILGDNNLKS||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||| g996ETVQKENIPAVLVGVPHITLGALFGHLSDHPLYEDLSEEYGIPLFGGAWAEILGNNNLKS       130       140       150       160       170       180       190       200 m996.pep DQIHANGKGYRKFAEDLNQFLRKQGFR|||||||||||||||:|||||||:||| g996 DQIHANGKGYRKFAENLNQFLRKHGFRX       190       200The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3011>:

a996.seq 1 ATGAACAGAA GAACCTTCCT CCTCGGCGCA GGCGCGTTGC TCCTTACCGC 51CTGCGGCAGA AAATCCGCCC GAACCCACGC CAAAATTCCC GAAGGAAGCA 101CCGTACTTGC CTTGGGCGAT TCGCTTACCT TCGGCTACGG CGCAAACCCC 151GGCGAATCCT ACCCCGCGCA ACTGCAAAAA CTGACGGGTT GGAATATTGT 201CAACGGCGGC GTATCGGGCG ATACATCCGC CCAAGCCCTG TCGCGCCTGC 251CCGCGCTGTT GGCACGCAAA CCCAAGCTTG TGATTGTCGG CATAGGCGGC 301AACGACTTTC TGCGCAAAGT TCCCAAGGAG CAGACCCGCG CCAATATCGC 351GAAAATCATC GAAACCGTGC AGAAGGAAAA CATCCCCGCC GTCCTCGTCG 401GCGTGCCGCA CATTACCTTG GGCGCGTTGT TCGGGCATTT GAGCGATCAT 451CCGCTGTATG AGGATTTGTC CGAGGAATAC GGCATTCCGC TGTTCGGCGG 501CGCGTGGGCG GAAATTTTGG GCGATAATAA TCTGAAATCC GACCAAATCC 551ACGCCAACGG CAAAGGCTAT CGGAAATTTG CCGAAGATTT GAATCAATTT 601TTGAGAAAAC AGGGGTTTAG ATAAThis corresponds to the amino acid sequence <SEQ ID 3012; ORF 996.a>:

a996.pep 1 MNRRTFLLGA GALLLTACGR KSARTHAKIP EGSTVLALGD SLTFGYGANP 51GESYPAQLQK LTGWNIVNGG VSGDTSAQAL SRLPALLARK PKLVIVGIGG 101NDFLRKVPKE QTRANIAKII ETVQKENIPA VLVGVPHITL GALFGHLSDH 151PLYEDLSEEY GIPLFGGAWA EILGDNNLKS DQIHANGKGY RKFAEDLNQF 201 LRKQGFR*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 996 shows 100.0% identity over a 207 aa overlap with a predicted ORF(ORF 996) from N. meningitidis

a996/m996 100.0% identity in 207 aa overlap        10        20        30        40        50        60 a996.pepMNRRTFLLGAGALLLTACGRKSARTHAKIPEGSTVLALGDSLTFGYGANPGESYPAQLQK|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m996MNRRTFLLGAGALLLTACGRKSARTHAKIPEGSTVLALGDSLTFGYGANPGESYPAQLQK        10        20        30        40        50        60        70        80        90       100       110       120 a996.pepLTGWNIVNGGVSGDTSAQALSRLPALLARKPKLVIVGIGGNDFLRKVPKEQTRANIAKII|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m996LTGWNIVNGGVSGDTSAQALSRLPALLARKPKLVIVGIGGNDFLRKVPKEQTRANIAKII        70        80        90       100       110       120       130       140       150       160       170       180 a996.pepETVQKENIPAVLVGVPHITLGALFGHLSDHPLYEDLSEEYGIPLFGGAWAEILGDNNLKS|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m996ETVQKENIPAVLVGVPHITLGALFGHLSDHPLYEDLSEEYGIPLFGGAWAEILGDNNLKS       130       140       150       160       170       180       190       200 a996.pep DQIHANGKGYRKFAEDLNQFLRKQGFRX||||||||||||||||||||||||||| m996 DQIHANGKGYRKFAEDLNQFLRKQGFR       190       200The following partial DNA sequence was identified in N. gonorrhoeae <SEQID 3013>:

g997.seq (partial) 1ATGATGAACA CGCCGCATCC GCGCCCGAAA ATCGCCGTCA TCGGCGCAGG 51CTGGGCCGGC TTGTCCGCCG CCGTCACCTT GGCGCGGCAC GCCGACGTTA 101CCCTGTTTGA AGCCGGCCGG CAGGCGGGCG GAAGGGCGCG CACACTGGCC 151GGAAATACCG ACGGTTTCGG TTTTTTGGAC AACGGGCAGC ACATTTTGCT 201CGGCGCATAC CGGGGCGTGT TGCGCCTGAT GAAAACCATC GGTTCAGACC 251CCCGTGCCGC CTTTTTGCGC GTACCGCTGC ACTGGCATAT GCACGGCGGT 301TTGCAGTTCC GCGCCCTCCC CCTGCCCGCG CCGCTGCATA TTTTGGGCGG 351CGTGCTGCTT GCCCGGCGCG TACCGTCCGC ATTCAAAGCC AAACTGCTTG 401CCGATATGTC CGATTTGCAG AAGTCCGCAC GCCTCGGACA GCCCGACACG 451ACAGTTGCAC AATGGCTGAA ACAGCGGAAC GTGCCGCGTG CCGCCGTAAT 501GCAGTTTTGG CAGCCCTTGG TCTGGGGCGC GCTCAACACG CCTTTGGAAA 551CCGCAAGCCT GCGCGTGTTG TGCAACGTTT TGTCCGACGG CGTGCTGACG 601AAAAAATCCG GCAGCGACTA TCTCCTACCC AAACAGGATT TGGGCGCAAT 651CGTCGCCGAA CCCGCCTTGG CGGAGCTTCA ACGGCTCGGC GCGGACATCC 701GCCTCGAAAC GCGCGTATGC CGTCTGAACA CCCTCCCGGA CGGAAAAGTC 751CTCGTCAACG GCGAAGCCTT CGATGCCGCC ATACTTGCCA CCGCGCCCTA 801CCACGCCGCC GCGCTCCTGC CCGAAGGCAC GCCCGAACAC GTTCAGACGG 851CATATCAAAA CCTTCGCTAC CACGCCATCA CCACCGTCTA TCTGCGCTAC 901GCCGAACCCG TCCGcCTGCc CGCCCCGCTG ACcGGCATtg CCGAcggcAC 951ggcaCaatgG CTGCTTTgcc cgGGGCAGGC tccggactgc CcccaaAacg 1001aagTCTCCGC cGTCAttagc GTTTCCGAcc GCGtcggcgC Gtttgcaaac 1051 cga...This corresponds to the amino acid sequence <SEQ ID 3014 ORF 997.ng>:

g997.pep (partial) 1MMNTPHPRPK IAVIGAGWAG LSAAVTLARH ADVTLFEAGR QAGGRARTLA 51GNTDGFGFLD NGQHILLGAY RGVLRLMKTI GSDPRAAFLR VPLHWHMHGG 101LQFRALPLPA PLHILGGVLL ARRVPSAFKA KLLADMSDLQ KSARLGQPDT 151TVAQWLKQRN VPRAAVMQFW QPLVWGALNT PLETASLRVL CNVLSDGVLT 201KKSGSDYLLP KQDLGAIVAE PALAELQRLG ADIRLETRVC RLNTLPDGKV 251LVNGEAFDAA ILATAPYHAA ALLPEGTPEH VQTAYQNLRY HAITTVYLRY 301AEPVRLPAPL TGIADGTAQW LLCPGQAPDC PQNEVSAVIS VSDRVGAFAN 351 R....The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3015>:

m997.seq 1 ATGATGAACA CGCCGCATCC GCGCCCGAAA ATCGCCGTCA TCGGCGCAGG 51CTGGGCAGGA CTGTCCGCCG CCGTCACCTT GGCGCGGCAC GCCGACGTTA 101CCCTGTTTGA AGCCGGCCGG CAGGCGGGCG GCAGGGCGCG CACACTGGCC 151GGAAATACCG ACGGTTTCGG TTTTTTGGAC AACGGGCAGC ACATTTTGCT 201CGGCGCATAC CGGGGCGTGT TGCGCCTGAT GAAAACCATC GGTTCGGATC 251CCCGTGCCGC CTTTTTGCGC GTACCGCTGC ACTGGCATAT GCACGGCGGT 301TTGCAGTTCC GCGCCCTCCC CCTGCCCGCG CCGCTGCATA TTTTGGGCGG 351CGTGCTGCTT GCCCGGCGTG CACCGACTGC ATTCAAAGCC AAACTGCTTG 401CCGATATGTC CGATTTGCAG AAGTCCGCAC GCCTCGGACA GCCCGACACG 451ACAGTGGCGC AATGGCTGAA ACAGCGGAAC GTGCCGCGTG CCGCCGTGAT 501GCAGTTTTGG CAGCCCTTGG TTTGGGGCGC GCTCAACACG CCTTTGGAAA 551CCGCAAGCCT GCGCGTGTTG TGCAACGTTT TGTCCGACGG CGTGCTGACG 601AAAAAATCCG GCAGCGACTA TCTCCTACCC AAGCAGGATT TGGGCGCAAT 651CGTCGCCGAA CCCGCCTTGG CGGATCTTCA ACGGCTCGGC GCGGACATCC 701GCCTCGAAAC GCGCGTATGC CGTCTGAACA CCCTCCCGGA CGGGAAAGTG 751CTCGTCAACG GCGAAGCTTT CGATGCCGCC GTCCCCGCCA CCGCGCCCTA 801CCACGCCGCC GCGCTCCTGC CCGAAGGCAC GCCCGAACAC GTTCAGACGG 851CATATCAAAA CCTTCGCTAC CACGCCATCA CCACCGTCTA TCTGCGCTAC 901GCCGAACCCG TCCGCCTGCC CGCCCCGCTG ACCGGCCTTG CCGACGGCAC 951GGTGCAATGG CTGCTTTGCC GGGGCAGGCT CGGACTGCCT GAAAACGAAG 1001TGTCCGCCGT CATCAGCGTT TCCGACCGCG TCGGCGCGTT TGCAAACCGG 1051GCGTGGGCGG ACAAAGCCCA CGCCGACCTC AAACGCATCC TTCCGCATTT 1101GGGCGAACCC GAAGCCGTGC GCGTCATCAC CGAAAAACGC GCCACAACCG 1151CAGCCGATGC CCCGCCGCCG GACTTGTCGT GGTTGCACCG GCACCGCATC 1201TTCCCCGCCG GCGACTACCT CCACCCGGAC TACCCCGCCA CGCTCGAAGC 1251CGCCGTACAA TCAGGTTTCG CGTCGGCGGA AGCCTGCCTG CAAAGCCTGA 1301GCGATGCCGT CTGAThis corresponds to the amino acid sequence <SEQ ID 3016; ORF 997>:

m997.pep 1 MMNTPHPRPK IAVIGAGWAG LSAAVTLARH ADVTLFEAGR QAGGRARTLA 51GNTDGFGFLD NGQHILLGAY RGVLRLMKTI GSDPRAAFLR VPLHWHMHGG 101LQFRALPLPA PLHILGGVLL ARRAPTAFKA KLLADMSDLQ KSARLGQPDT 151TVAQWLKQRN VPRAAVMQFW QPLVWGALNT PLETASLRVL CNVLSDGVLT 201KKSGSDYLLP KQDLGAIVAE PALADLQRLG ADIRLETRVC RLNTLPDGKV 251LVNGEAFDAA VPATAPYHAA ALLPEGTPEH VQTAYQNLRY HAITTVYLRY 301AEPVRLPAPL TGLADGTVQW LLCRGRLGLP ENEVSAVISV SDRVGAFANR 351AWADKAHADL KRILPHLGEP EAVRVITEKR ATTAADAPPP DLSWLHRHRI 401FPAGDYLHPD YPATLEAAVQ SGFASAEACL QSLSDAV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. gonorrhoeaeORF 997 shows 96.0% identity over a 351 aa overlap with a predicted ORF(ORF 997) from N. gonorrhoeae

g997/m997 96.0% identity in 351 aa overlap        10        20        30        40        50        60 g997.pepMMNTPHPRPKIAVIGAGWAGLSAAVTLARHADVTLFEAGRQAGGRARTLAGNTDGFGFLD|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m997MMNTPHPRPKIAVIGAGWAGLSAAVTLARHADVTLFEAGRQAGGRARTLAGNTDGFGFLD        10        20        30        40        50        60        70        80        90       100       110       120 g997.pepNGQHILLGAYRGVLRLMKTIGSDPRAAFLRVPLHWHMHGGLQFRALPLPAPLHILGGVLL|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m997NGQHILLGAYRGVLRLMKTIGSDPRAAFLRVPLHWHMHGGLQFRALPLPAPLHILGGVLL        70        80        90       100       110       120       130       140       150       160       170       180 g997.pepARRVPSAFKAKLLADMSDLQKSARLGQPDTTVAQWLKQRNVPRAAVMQFWQPLVWGALNT|||:|:|||||||||||||||||||||||||||||||||||||||||||||||||||||| m997ARRAPTAFKAKLLADMSDLQKSARLGQPDTTVAQWLKQRNVPRAAVMQFWQPLVWGALNT       130       140       150       160       170       180       190       200       210       220       230       240 g997.pepPLETASLRVLCNVLSDGVLTKKSGSDYLLPKQDLGAIVAEPALAELQRLGADIRLETRVC||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||| m997PLETASLRVLCNVLSDGVLTKKSGSDYLLPKQDLGAIVAEPALADLQRLGADIRLETRVC       190       200       210       220       230       240       250       260       270       280       290       300 g997.pepRLNTLPDGKVLVNGEAFDAAILATAPYHAAALLPEGTPEHVQTAYQNLRYHAITTVYLRY||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||| m997RLNTLPDGKVLVNGEAFDAAVPATAPYHAAALLPEGTPEHVQTAYQNLRYHAITTVYLRY       250       260       270       280       290       300       310       320       330       340       350 g997.pepAEPVRLPAPLTGIADGTAQWLLCPGQAPDCPQNEVSAVISVSDRVGAFANR||||||||||||:||||:||||| |:    |:||||||||||||||||||| m997AEPVRLPAPLTGLADGTVQWLLCRGRL-GLPENEVSAVISVSDRVGAFANRAWADKAHAD       310       320        330       340       350The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3017>:

a997.seq 1 ATGATGAACA CGCCGCATCC GCGCCCGAAA ATCGCCGTCA TCGGCGCAGG 51CTGGGCCGGC TTGTCCGCCG CCGTTACCTT GGCGCGGCAC GCCGACGTTA 101CCCTGTTTGA AGCCGGCCGG CAGGCGGGCG GCAGGGCGCG CGCACTGGCC 151GGAAATACCG ACGGTTTCGG TTTTTTGGAC AACGGGCAGC ATATTTTACT 201CGGCGCATAC CGGGGCGTGT TGCGCCTGAT GAAAACCATC GGTTCAGACC 251CCCATGCCGC CTTTTTGCGC GTACCGCTGC ACTGGCATAT GCACGGCGGT 301TTGCAGTTCC GCGCCCTCCC CCTGCCCGCG CCCCTGCATA TTTTGGGCGG 351CGTGCTGCTT GCCCGGCGCG TACCGTCCGC ATTCAAAGCC AAACTGCTTG 401CCGATATGTC CGATTTGCAG AAGTCCGCAC GCCTCGGACA GCCCGACACG 451ACAGTGGCGC AATGGCTGAA ACAGCGGAAC GTGCCGCGTG CCGCCGTAAT 501GCAGTTTTGG CAGCCCTTGG TTTGGGGCGC GCTCAACACG CCTTTGGAAA 551CCGCAAGCCT GCGCGTGTTG TGCAACGTTT TGTCCGACGG CGTGCTGACG 601AAAAAATCCG GCAGCGACTA TCTCCTACCC AAACAGGATT TGGGCGCAAT 651CGTCGCCGAA CCCGCCTTGG CGGAGCTTCA ACGGCTCGGC GCGGACATCC 701GCCTCGAAAC GCGCATATGC CGTCTGAACA CCCTCCCGGA CGGGAAAGTG 751CTCGTCAACG GCGAACCTTT CGATGCCGCC GTCCCCGCCA CCGCGCCCTA 801CCACGCCGCC GCGCTCCTGC CCGAAGGCAC GCCCGAACAC GTTCAGACGG 851CATATCAAAA CCTTCGCTAT CACGCCATCA CCACCGTCTA TCTGCGCTAT 901GCCGAACCCG TCCGCTTGCC TGCCCCGCTG ACCGGACTTG CCGACGGCAC 951GGTGCAATGG CTGCTTTGCC GGGGCAGGCT CGGACTGCCT GAAAACGAAG 1001TGTCCGCCGT CATCAGCGTT TCCGACCGCG TCGGCGCGTT TGCAAACCGG 1051GCGTGGGCGG ACAAAGTTCA CGCCGACCTC AAACGCATCC TTCCGCATTT 1101GGGCGAACCC GAAGCCGTGC GCGTCATCAC CGAAAAACGC GCCACAACCG 1151CAGCCGATGC CCCGCCGCCG GATTTGTCGT GGTTGCACCG GCACCGCATC 1201TTCCCCGCCG GCGACTACCT CCACCCAGAC TACCCCGCCA CGCTCGAAGC 1251CGCCGTACAA TCAGGTTTCG CGTCGGCGGA AGCCTGCCTG CAAAGCCTGA 1301GCGATGCCGT CTGAThis corresponds to the amino acid sequence <SEQ ID 3018; ORF 997.a>:

a997.pep 1 MMNTPHPRPK IAVIGAGWAG LSAAVTLARH ADVTLFEAGR QAGGRARALA 51GNTDGFGFLD NGQHILLGAY RGVLRLMKTI GSDPHAAFLR VPLHWHMHGG 101LQFRALPLPA PLHILGGVLL ARRVPSAFKA KLLADMSDLQ KSARLGQPDT 151TVAQWLKQRN VPRAAVMQFW QPLVWGALNT PLETASLRVL CNVLSDGVLT 201KKSGSDYLLP KQDLGAIVAE PALAELQRLG ADIRLETRIC RLNTLPDGKV 251LVNGEPFDAA VPATAPYHAA ALLPEGTPEH VQTAYQNLRY HAITTVYLRY 301AEPVRLPAPL TGLADGTVQW LLCRGRLGLP ENEVSAVISV SDRVGAFANR 351AWADKVHADL KRILPHLGEP EAVRVITEKR ATTAADAPPP DLSWLHRHRI 401FPAGDYLHPD YPATLEAAVQ SGFASAEACL QSLSDAV*Computer analysis of this amino acid sequence gave the followingresults:Homology with a Predicted ORF from N. meningitidisORF 997 shows 98.2% identity over a 437 aa overlap with a predicted ORF(ORF 997) from N. meningitidis

a997/m997 98.2% identity in 437 aa overlap        10        20        30        40        50        60 a997.pepMMNTPHPRPKIAVIGAGWAGLSAAVTLARHADVTLFEAGRQAGGRARALAGNTDGFGFLD|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||| m997MMNTPHPRPKIAVIGAGWAGLSAAVTLARHADVTLFEAGRQAGGRARTLAGNTDGFGFLD        10        20        30        40        50        60        70        80        90       100       110       120 a997.pepNGQHILLGAYRGVLRLMKTIGSDPHAAFLRVPLHWHMHGGLQFRALPLPAPLHILGGVLL||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||| m997NGQHILLGAYRGVLRLMKTIGSDPRAAFLRVPLHWHMHGGLQFRALPLPAPLHILGGVLL        70        80        90       100       110       120       130       140       150       160       170       180 a997.pepARRVPSAFKAKLLADMSDLQKSARLGQPDTTVAQWLKQRNVPRAAVMQFWQPLVWGALNT|||:|:|||||||||||||||||||||||||||||||||||||||||||||||||||||| m997ARRAPTAFKAKLLADMSDLQKSARLGQPDTTVAQWLKQRNVPRAAVMQFWQPLVWGALNT       130       140       150       160       170       180       190       200       210       220       230       240 a997.pepPLETASLRVLCNVLSDGVLTKKSGSDYLLPKQDLGAIVAEPALAELQRLGADIRLETRIC||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||:| m997PLETASLRVLCNVLSDGVLTKKSGSDYLLPKQDLGAIVAEPALADLQRLGADIRLETRVC       190       200       210       220       230       240       250       260       270       280       290       300 a997.pepRLNTLPDGKVLVNGEPFDAAVPATAPYHAAALLPEGTPEHVQTAYQNLRYHAITTVYLRY||||||||||||||| |||||||||||||||||||||||||||||||||||||||||||| m997RLNTLPDGKVLVNGEAFDAAVPATAPYHAAALLPEGTPEHVQTAYQNLRYHAITTVYLRY       250       260       270       280       290       300       310       320       330       340       350       360 a997.pepAEPVRLPAPLTGLADGTVQWLLCRGRLGLPENEVSAVISVSDRVGAFANRAWADKVHADL|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||| m997AEPVRLPAPLTGLADGTVQWLLCRGRLGLPENEVSAVISVSDRVGAFANRAWADKAHADL       310       320       330       340       350       360       370       380       390       400       410       420 a997.pepKRILPHLGEPEAVRVITEKRATTAADAPPPDLSWLHRHRIFPAGDYLHPDYPATLEAAVQ|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| m997KRILPHLGEPEAVRVITEKRATTAADAPPPDLSWLHRHRIFPAGDYLHPDYPATLEAAVQ       370       380       390       400       410       420        430a997.pep SGFASAEACLQSLSDAVX |||||||||||||||||| m997 SGFASAEACLQSLSDAVX       430

g999.seq Not found yet

g999.pep Not found yet

The following partial DNA sequence was identified in N. meningitidis<SEQ ID 3019>:

m999.seq 1 ATGAATATGA AAAAATTGAT TTCCGCAATT TGTGTTTCAA TTGTTTTATC 51AGCCTGCAAC CAACAATCAA AAACGGCACA AGCCGAAGAA CCTGTCCAAA 101GTATCCAGGC TGCTGATTGT ACCGCCCCAA TGGACATCAC AGTTGAACAA 151TATCTCATCA ATTTGGAGCA AGCATTTAAA ACTCAGAACG TCTCAACAAA 201AATCCATAAT AAAAATATTG TCAAGACCGA TTGTGGTTAT GACCTTACTT 251TGGTAATGGA TTTTGGGGCG ATTGCGCTCA AACTGGACGA GCAGCAAAAA 301ATTAGAGCTA TCTCAGTAGG CTACATTTTA AAAACCGACG GAGAGAAAGG 351ACAAAATCTA GTCAATAATG CCATAAATGG ATTACACAGT ATTCAGGCAG 401TTCTGTCTTT AACTACCACA GACAAATTGG GCGAATCGGA AGCAGGAAAA 451CAACTTTTTA CAGCTTTAAC CGAAGTCGTC AAAGAATCCA ATCAGACAGG 501AGCAACAGCG CAAAAAGACG TTCCGGCAGA TGGTATTTTA TATAGCGTTG 551TTTTTGAAAA AGAAACAAAC ACCATTGCAA TAATCGGCAG AAAACAACCC 601 TAAThis corresponds to the amino acid sequence <SEQ ID 3020; ORF 999>:

m999.pep 1 MNMKKLISAI CVSIVLSACN QQSKTAQAEE PVQSIQAADC TAPMDITVEQ 51YLINLEQAFK TQNVSTKIHN KNIVKTDCGY DLTLVMDFGA IALKLDEQQK 101IRAISVGYIL KTDGEKGQNL VNNAINGLHS IQAVLSLTTT DKLGESEAGK 151QLFTALTEVV KESNQTGATA QKDVPADGIL YSVVFEKETN TIAIIGRKQP *

a999.seq Not found yet

a999.pep Not found yet

The foregoing examples are intended to illustrate but not to limit theinvention.

1. (canceled)
 2. A protein comprising (i) a fragment of at least sevenconsecutive amino acids from an amino acid sequence selected from thegroup consisting of SEQ ID NO: 2916; SEQ ID NO: 2918, and SEQ ID NO:2920, or (ii) an amino acid sequence having at least 80% identity to oneof SEQ ID NO: 2916; SEQ ID NO: 2918, and SEQ ID NO:
 2920. 3. The proteinof claim 2 comprising the fragment, wherein the fragment comprises atleast ten consecutive amino acids from an amino acid sequence selectedfrom the group consisting of SEQ ID NO: 2916; SEQ ID NO: 2918, and SEQID NO:
 2920. 4. The protein of claim 3, wherein the fragment comprisesat least fourteen consecutive amino acids from an amino acid sequenceselected from the group consisting of SEQ ID NO: 2916; SEQ ID NO: 2918,and SEQ ID NO:
 2920. 5. The protein of claim 3, wherein the fragmentcomprises at least twenty consecutive amino acids from an amino acidsequence selected from the group consisting of SEQ ID NO: 2916; SEQ IDNO: 2918, and SEQ ID NO:
 2920. 6. The protein of claim 2 comprising theamino acid sequence having at least 80% identity to one of SEQ ID NO:2916; SEQ ID NO: 2918, and SEQ ID NO:
 2920. 7. The protein of claim 6,wherein the amino acid sequence has at least 85% identity to one of SEQID NO: 2916; SEQ ID NO: 2918, and SEQ ID NO:
 2920. 8. A compositioncomprising the protein of claim 2 and a pharmaceutically acceptableexcipient.
 9. The composition of claim 8, further comprising anadjuvant.
 10. The composition of claim 9, wherein the adjuvant is analuminum salt adjuvant.
 11. The composition of claim 10, wherein thealuminum salt adjuvant comprises aluminum hydroxide.
 12. The compositionof claim 9, wherein the protein comprises the fragment and the fragmentcomprises at least ten consecutive amino acids from an amino acidsequence selected from the group consisting of SEQ ID NO: 2916; SEQ IDNO: 2918, and SEQ ID NO:
 2920. 13. The composition of claim 12, whereinthe fragment comprises at least fourteen consecutive amino acids from anamino acid sequence selected from the group consisting of SEQ ID NO:2916; SEQ ID NO: 2918, and SEQ ID NO:
 2920. 14. The composition of claim12, wherein the fragment comprises at least twenty consecutive aminoacids from an amino acid sequence selected from the group consisting ofSEQ ID NO: 2916; SEQ ID NO: 2918, and SEQ ID NO:
 2920. 15. Thecomposition of claim 9, wherein the protein comprises the amino acidsequence having at least 80% identity to one of SEQ ID NO: 2916; SEQ IDNO: 2918, and SEQ ID NO:
 2920. 16. The composition of claim 15, whereinthe amino acid sequence has at least 85% identity to one of SEQ ID NO:2916; SEQ ID NO: 2918, and SEQ ID NO:
 2920. 17. A method of inducing animmune response in a subject comprising administering the composition ofclaim 9 to the subject.